Sample records for choosing intermediate products

  1. Intermediate hepatocellular carcinoma: How to choose the best treatment modality? (United States)

    Di Costanzo, Giovan Giuseppe; Tortora, Raffaella


    Intermediate stage, or stage B according to Barcelona Clinic Liver Cancer classification, of hepatocellular carcinoma (HCC) comprises a heterogeneous population with different tumor burden and liver function. This heterogeneity is confirmed by the large variability of treatment choice and disease-relate survival. The aim of this review was to highlight the existing evidences regarding this specific topic. In a multidisciplinary evaluation, patients with large (> 5 cm) solitary HCC should be firstly considered for liver resection (LR). When LR is unfeasible, locoregional treatments are evaluable therapeutic options, being transarterial chemoembolization (TACE), the most used procedure. Percutaneous ablation can be an evaluable treatment for large HCC. However, the efficacy of all ablative procedures decrease as tumor size increases over 3 cm. In clinical practice, a combination treatment strategy [TACE or transarterial radioembolization (TARE)-plus percutaneous ablation] is "a priori" preferred in a relevant percentage of these patients. On the other hands, sorafenib is the treatment of choice in patients who are unsuitable to surgery and/or with a contraindication to locoregional treatments. In multifocal HCC, TACE is the first-line treatment. The role of TARE is still undefined. Surgery may have also a role in the treatment of multifocal HCC in selected cases (patients with up to three nodules, multifocal HCC involving 2-3 adjacent liver segments). In some patients with bilobar disease the combination of LR and ablative treatment may be a valuable option. The choice of the best treatment in the patient with intermediate stage HCC should be "patient-tailored" and made by a multidisciplinary team.

  2. Intermediate hepatocellular carcinoma: How to choose the best treatment modality? (United States)

    Di Costanzo, Giovan Giuseppe; Tortora, Raffaella


    Intermediate stage, or stage B according to Barcelona Clinic Liver Cancer classification, of hepatocellular carcinoma (HCC) comprises a heterogeneous population with different tumor burden and liver function. This heterogeneity is confirmed by the large variability of treatment choice and disease-relate survival. The aim of this review was to highlight the existing evidences regarding this specific topic. In a multidisciplinary evaluation, patients with large (> 5 cm) solitary HCC should be firstly considered for liver resection (LR). When LR is unfeasible, locoregional treatments are evaluable therapeutic options, being transarterial chemoembolization (TACE), the most used procedure. Percutaneous ablation can be an evaluable treatment for large HCC. However, the efficacy of all ablative procedures decrease as tumor size increases over 3 cm. In clinical practice, a combination treatment strategy [TACE or transarterial radioembolization (TARE)-plus percutaneous ablation] is “a priori” preferred in a relevant percentage of these patients. On the other hands, sorafenib is the treatment of choice in patients who are unsuitable to surgery and/or with a contraindication to locoregional treatments. In multifocal HCC, TACE is the first-line treatment. The role of TARE is still undefined. Surgery may have also a role in the treatment of multifocal HCC in selected cases (patients with up to three nodules, multifocal HCC involving 2-3 adjacent liver segments). In some patients with bilobar disease the combination of LR and ablative treatment may be a valuable option. The choice of the best treatment in the patient with intermediate stage HCC should be “patient-tailored” and made by a multidisciplinary team. PMID:26019734

  3. Intermediate hepatocellular carcinoma: How to choose thebest treatment modality?

    Institute of Scientific and Technical Information of China (English)


    Intermediate stage, or stage B according to BarcelonaClinic Liver Cancer classification, of hepatocellularcarcinoma (HCC) comprises a heterogeneous populationwith different tumor burden and liver function. Thisheterogeneity is confirmed by the large variability oftreatment choice and disease-relate survival. The aimof this review was to highlight the existing evidencesregarding this specific topic. In a multidisciplinaryevaluation, patients with large (〉 5 cm) solitary HCC should be firstly considered for liver resection (LR).When LR is unfeasible, locoregional treatments areevaluable therapeutic options, being transarterialchemoembolization (TACE), the most used procedure.Percutaneous ablation can be an evaluable treatmentfor large HCC. However, the efficacy of all ablativeprocedures decrease as tumor size increases over 3 cm.In clinical practice, a combination treatment strategy[TACE or transarterial radioembolization (TARE)-plus percutaneous ablation] is "a priori" preferredin a relevant percentage of these patients. On theother hands, sorafenib is the treatment of choice inpatients who are unsuitable to surgery and/or witha contraindication to locoregional treatments. Inmultifocal HCC, TACE is the first-line treatment. Therole of TARE is still undefined. Surgery may have alsoa role in the treatment of multifocal HCC in selectedcases (patients with up to three nodules, multifocalHCC involving 2-3 adjacent liver segments). In somepatients with bilobar disease the combination of LR andablative treatment may be a valuable option. The choiceof the best treatment in the patient with intermediatestage HCC should be "patient-tailored" and made by amultidisciplinary team.

  4. The GEOTRACES Intermediate Data Product 2014

    NARCIS (Netherlands)

    Mawji, Edward; Schlitzer, Reiner; Dodas, Elena Masferrer; Abadie, Cyril; Abouchami, Wafa; Anderson, Robert F.; Baars, Oliver; Bakker, Karel; Baskaran, Mark; Bates, Nicholas R.; Bluhm, Katrin; Bowie, Andrew; Bown, Johann; Boye, Marie; Boyle, Edward A.; Branellec, Pierre; Bruland, Kenneth W.; Brzezinski, Mark A.; Bucciarelli, Eva; Buesseler, Ken; Butler, Edward; Cai, Pinghe; Cardinal, Damien; Casciotti, Karen; Chaves, Joaquin; Cheng, Hai; Chever, Fanny; Church, Thomas M.; Colman, Albert S.; Conway, Tim M.; Croot, Peter L.; Cutter, Gregory A.; de Souza, Gregory F.; Dehairs, Frank; Deng, Feifei; Huong Thi Dieu, [Unknown; Dulaquais, Gabriel; Echegoyen-Sanz, Yolanda; Edwards, R. Lawrence; Fahrbach, Eberhard; Fitzsimmons, Jessica; Fleisher, Martin; Frank, Martin; Friedrich, Jana; Fripiat, Francois; Galer, Stephen J. G.; Gamo, Toshitaka; Solsona, Ester Garcia; Gerringa, Loes J. A.; Godoy, Jose Marcus; Gonzalez, Santiago; Grossteffan, Emilie; Hatta, Mariko; Hayes, Christopher T.; Heller, Maija Iris; Henderson, Gideon; Huang, Kuo-Fang; Jeandel, Catherine; Jenkins, William J.; John, Seth; Kenna, Timothy C.; Klunder, Maarten; Kretschmer, Sven; Kumamoto, Yuichiro; Laan, Patrick; Labatut, Marie; Lacan, Francois; Lam, Phoebe J.; Lannuzel, Delphine; le Moigne, Frederique; Lechtenfeld, Oliver J.; Lohan, Maeve C.; Lu, Yanbin; Masque, Pere; McClain, Charles R.; Measures, Christopher; Middag, Rob; Moffett, James; Navidad, Alicia; Nishioka, Jun; Noble, Abigail; Obata, Hajime; Ohnemus, Daniel C.; Owens, Stephanie; Planchon, Frederic; Pradoux, Catherine; Puigcorbe, Viena; Quay, Paul; Radic, Amandine; Rehkaemper, Mark; Remenyi, Tomas; Rijkenberg, Micha J. A.; Rintoul, Stephen; Robinson, Laura F.; Roeske, Tobias; Rosenberg, Mark; van der Loeff, Michiel Rutgers; Ryabenko, Evgenia; Saito, Mak A.; Roshan, Saeed; Salt, Lesley; Sarthou, Geraldine; Schauer, Ursula; Scott, Peter; Sedwick, Peter N.; Sha, Lijuan; Shiller, Alan M.; Sigman, Daniel M.; Smethie, William; Smith, Geoffrey J.; Sohrin, Yoshiki; Speich, Sabrina; Stichel, Torben; Stutsman, Johnny; Swift, James H.; Tagliabue, Alessandro; Thomas, Alexander; Tsunogai, Urumu; Twining, Benjamin S.; van Aken, Hendrik M.; van Heuven, Steven; van Ooijen, Jan; van Weerlee, Evaline; Venchiarutti, Celia; Voelker, Antje H. L.; Wake, Bronwyn; Warner, Mark J.; Woodward, E. Malcolm S.; Wu, Jingfeng; Wyatt, Neil; Yoshikawa, Hisayuki; Zheng, Xin-Yuan; Xue, Zichen; Zieringer, Moritz; Zimmer, Louise A.; de Baar, Henricus


    The GEOTRACES Intermediate Data Product 2014 (IDP2014) is the first publicly available data product of the international GEOTRACES programme, and contains data measured and quality controlled before the end of 2013. It consists of two parts: (1) a compilation of digital data for more than 200 trace

  5. Intermediate product selection and blending in the food processing industry

    DEFF Research Database (Denmark)

    Kilic, Onur A.; Akkerman, Renzo; van Donk, Dirk Pieter


    This study addresses a capacitated intermediate product selection and blending problem typical for two-stage production systems in the food processing industry. The problem involves the selection of a set of intermediates and end-product recipes characterising how those selected intermediates...

  6. How "Sustainability" is Changing How We Make and Choose Products

    Energy Technology Data Exchange (ETDEWEB)

    Cheryl O' Brien


    What does Sustainability mean, and why should people in the thermophysical properties business care? This paper will describe sustainability in the context of product development, which is where much of the buzz is currently being generated. Once described, it will discuss how expectations for Sustainability are changing product lines, and then discuss the controversial issues now emerging from trying to measure Sustainability. One of the most organized efforts in the U.S. is the U.S. Green Building Council revolutionizing how the built environment is conceptualized, designed, built, used, and disposed of - and born again. The appeal of the US Green Building Council is that it has managed to checklist how to "do" Sustainability. By following this checklist, better described as a rating system, a more Sustainable product should be achieved. That is, a product that uses less energy, less water, is less noxious to the user, and consumes fewer resources. We care because these Sustainable products are viewed as preferable by a growing number of consumers and, consequently, are more valuable. One of the most interesting aspects of the Sustainability movement is a quantitative assessment of how sustainable a product is. Life Cycle Assessment techniques (not to be confused with life cycle economic costs) developed since the early 1990s are gaining ground as a less biased method to measure the ultimate "bad" consequences of creating a product (depletion of natural resources, nutrification, acid rain, air borne particulates, solid waste, etc.). For example, one assertion is that these studies have shown that recycling can sometimes do more environmental harm than good.

  7. Fluorine production in intermediate-mass stars

    CERN Document Server

    Mowlavi, N; Arnould, M


    The 19F production during the first dozen thermal pulses of AGB stars with (M=3,Z=0.02), (M=6,Z=0.02) and (M=3,Z=0.001) is investigated on grounds of detailed stellar models and of revised rates for 15N(a,g)19F and 18O(a,g)22Ne. These calculations confirm an early expectation that 19F {\\it is} produced in AGB thermal pulses. They also enlarge substantially these previous results by showing that the variations of the level of 19F production during the evolution is very sensitive to the maximum temperature reached at the base of the pulse. These variations are analyzed in detail, and are shown to result from a subtle balance between different nuclear effects (mainly 19F production or destruction in a pulse, and 15N synthesis during the interpulse), possibly super-imposed on dilution effects in more or less extended pulse convective tongues. Our calculations, as most others, do not predict the third dredge-up self- consistently. When parametrized, it appears that our models of intermediate-mass AGB stars are abl...

  8. Choosing an Appropriate Method for Sustained Release Flurbiprofen Pellet Production

    Directory of Open Access Journals (Sweden)

    S. Zenginer


    Full Text Available Flurbiprofen is a slightly water soluble, nonsteroidal anti-inflammatory active ingredient with analgesic and antipyretic activity. The purpose of this study was to develop an appropriate pellet production method for pH independent sustained release pellet formulation of flurbiprofen. Flurbiprofen pellets were produced by three different production methods; Suspension Layering, Extrusion Spherization, Rotagranulation. Although the simple and fast processing properties of Extrusion Spheronization and Rotagranulation methods, according to visual control and comparative dissolution profiles, Suspension Layering method was found more suitable for Flurbiprofen SR (Sustained Release having high drug load for each single dose. Beginning with the spherical core has brought great advantage to Suspension Layering method, since ideal sphericity could not be reached at Extrusion Spheronization and Rotagranulation methods due to limited microcrystalline cellulose amount.

  9. 27 CFR 17.185 - Requirements for intermediate products and unfinished nonbeverage products. (United States)


    ... intermediate products and unfinished nonbeverage products. 17.185 Section 17.185 Alcohol, Tobacco Products and... for intermediate products and unfinished nonbeverage products. (a) General. Self-manufactured ingredients made with taxpaid spirits may be accounted for either as intermediate products or as...

  10. Associated strangeness production at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Saghai, B.


    Elementary strangeness production reactions with hadronic and electromagnetic probes are briefly reviewed. Some recent theoretical and experimental findings are underlined and a few open questions are singled out. (author). 59 refs.

  11. Choosing Beauty and Feeling Good: How Attractive Product Design Increases Self-Affirmation

    Directory of Open Access Journals (Sweden)

    Townsend Claudia


    Full Text Available Consumers construct and maintain self-concepts through the use of branded consumer products. Yet product choice not only reflects an actual or desired image of the self but can also directly influence a person’s sense of self and even boost self-esteem. The aesthetics of a product is an attribute that has the power to transform how consumers perceive themselves. The mere act of choosing a beautiful product over a less good-looking one affirms people’s sense of self - who they are and what their values are. It goes beyond personal image building and self-presentation; its impact is also turned inwards. Choice of high design works as a unique form of affirmation. It works unconsciously, and high design may even be a particularly powerful form of affirmation precisely because its relationship to the self and one’s values is not obvious. And design is more powerful than other features in this respect. Comfort and ease of use, taste and brand do not have the same self-affirming quality as design. It is not simply that “treating” oneself or going for the pleasurable option has an affirming effect; it is specific to the choice of aesthetics.

  12. 75 FR 33824 - Pharmaceutical Products and Chemical Intermediates, Fourth Review: Advice Concerning the Addition... (United States)


    ... COMMISSION Pharmaceutical Products and Chemical Intermediates, Fourth Review: Advice Concerning the Addition of Certain Products to the Pharmaceutical Appendix to the HTS AGENCY: United States International... (Commission) instituted investigation No. 332-520, Pharmaceutical Products and Chemical Intermediates,...

  13. Strange particle production at low and intermediate energies

    CERN Document Server

    Alam, M Rafi; Athar, M Sajjad; Vacas, M J Vicente


    The weak kaon production off the nucleon induced by neutrinos and antineutrinos is studied at low and intermediate energies of interest for some ongoing and future neutrino oscillation experiments. We develop a microscopical model based on the SU(3) chiral Lagrangians. The studied mechanisms are the main source of kaon production for neutrino energies up to 2 GeV for the various channels and the cross sections are large enough to be amenable to be measured by experiments such as Minerva, T2K and NO$\

  14. Choosing the right platform for the right product: Sustainable production of chemicals in microbial cell factories

    DEFF Research Database (Denmark)

    Herrgard, Markus

    are taken through four stages: 1) In silico design and data analysis, 2) genome engineering, 3) characterization and high throughput screening, and 4) omics based systems analysis. However, before entering this loop, significant two significant decisions need to be made. First, the choice of what products...... should be made should be made considering biological, technical, economic, and ecological factors. Second, the choice which platform strains will be used to develop production hosts should be made based on characterization of both metabolic and process tolerance traits of strains. I will discuss the role...

  15. Product prioritization in a two-stage food production system with intermediate storage

    DEFF Research Database (Denmark)

    Akkerman, Renzo; van Donk, Dirk Pieter


    In the food-processing industry, usually a limited number of storage tanks for intermediate storage is available, which are used for different products. The market sometimes requires extremely short lead times for some products, leading to prioritization of these products, partly through the dedi......In the food-processing industry, usually a limited number of storage tanks for intermediate storage is available, which are used for different products. The market sometimes requires extremely short lead times for some products, leading to prioritization of these products, partly through...... the dedication of a storage tank. This type of situation has hardly been investigated, although planners struggle with it in practice. This paper aims at investigating the fundamental effect of prioritization and dedicated storage in a two-stage production system, for various product mixes. We show...

  16. 27 CFR 17.155 - Spirits consumed in manufacturing intermediate products. (United States)


    ... manufacturing intermediate products. 17.155 Section 17.155 Alcohol, Tobacco Products and Firearms ALCOHOL AND... USED IN MANUFACTURING NONBEVERAGE PRODUCTS Claims for Drawback Spirits Subject to Drawback § 17.155 Spirits consumed in manufacturing intermediate products. Spirits consumed in the manufacture of...

  17. Improved enzymatic production of phenolated glycerides through alkyl phenolate intermediate

    DEFF Research Database (Denmark)

    Yang, Zhiyong; Feddern, Vivian; Glasius, Marianne


    This work reported a novel approach for synthesis of dihydrocaffoylated glycerides, consisting of 2 steps: enzymatic synthesis of octyl dihydrocaffeate (as a synthetic intermediate) from octanol and dihydrocaffeic acid (DHCA), and enzymatic interesterification of triglycerides with octyl dihydroc...

  18. From productivity strategy to business case : Choosing a cost-effective intervention for workplace innovations

    NARCIS (Netherlands)

    Oeij, P.R.A.; Looze, M.P. de; Have, K. ten; Rhijn, J.W. van; Graaf, H.A.L.M. de


    The article presents an approach to developing cost-effective interventions for workplace innovations for entrepreneurs who seek to enhance the productivity of an organization. The business case method is used to extend the Q4-model of productivity, which supports developing a productivity strategy

  19. Mechanism study on UV-induced photodegradation of nonylphenol ethoxylates by intermediate products analysis

    Institute of Scientific and Technical Information of China (English)

    Ling Chen; Hai Yun Zhou; Lan Liu; Qin Ying Deng


    Photodegradation of nonylphenol ethoxylates (NP10EO) was investigated in laboratory scale under UV irradiation. The intermediate photodegradation products were analyzed by LC-ESI-MS. Three kinds of intermediate products including aldehydic compounds, carboxylic compounds and cyclohexanyl compounds were identified. Five main degradation routes involving the oxidation of the alkyl chain and ethoxylate unit, shortening of the alkyl chain and ethoxylate unit, hydrogenation of the benzene ring were proposed.

  20. Formation and degradation of valuable intermediate products during wet oxidation of municipal sludge. (United States)

    Baroutian, Saeid; Gapes, Daniel J; Sarmah, Ajit K; Farid, Mohammed M; Young, Brent R


    The current study investigated the formation of organic acids and alcohols as major intermediate products of wet oxidation of municipal sludge. Municipal sludge was subjected to 60-min wet oxidation at temperatures ranging from 220 to 240°C, with 20bar oxygen partial pressure. Acetic acid was the main intermediate compound produced in this study, followed by propionic, n-butyric, iso-butyric and pentanoic acids and methanol. It was found that the process severity has a significant influence on the formation and degradation of these intermediate products.

  1. Intermediate mass black holes in AGN disks: I. Production & Growth

    CERN Document Server

    McKernan, B; Lyra, W; Perets, H B


    Here we propose a mechanism for efficiently growing intermediate mass black holes (IMBH) in disks around supermassive black holes. Stellar mass objects can efficiently agglomerate when facilitated by the gas disk. Stars, compact objects and binaries can migrate, accrete and merge within disks around supermassive black holes. While dynamical heating by cusp stars excites the velocity dispersion of nuclear cluster objects (NCOs) in the disk, gas in the disk damps NCO orbits. If gas damping dominates, NCOs remain in the disk with circularized orbits and large collision cross-sections. IMBH seeds can grow extremely rapidly by collisions with disk NCOs at low relative velocities, allowing for super-Eddington growth rates. Once an IMBH seed has cleared out its feeding zone of disk NCOs, growth of IMBH seeds can become dominated by gas accretion from the AGN disk. However, the IMBH can migrate in the disk and expand its feeding zone, permitting a super-Eddington accretion rate to continue. Growth of IMBH seeds via N...

  2. Analysis of Intermediate Product Price and Social Welfare in the Vertical Merger of Enterprises

    Institute of Scientific and Technical Information of China (English)

    YU Juan; CHEN Shao-gang


    According to the different products that two upper enterprises produce, this paper analyzes the transfer pricing of intermediate product and the effect of social welfare of vertical merger under imperfect competition market. The conclusions are: the transfer pricing of intermediate product is equal to marginal cost; the perfect outputs that upper enterprises sell to the market before and after the vertical merger of enterprises are the same; the product price in the integrated enterprises may be higher, lower or equal to the price in non-integrated enterprises.

  3. Electrochemical Detection of Transient Cobalt Hydride Intermediates of Electrocatalytic Hydrogen Production. (United States)

    Wiedner, Eric S; Bullock, R Morris


    A large variety of molecular cobalt complexes are used as electrocatalysts for H2 production, but the key cobalt hydride intermediates are frequently difficult to detect and characterize due to their high reactivity. We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2. In both cases, reduction of a transient catalytic intermediate occurs at a potential that coincides with the Co(II/I) couple. Each reduction displays quasireversible electron-transfer kinetics, consistent with reduction of a Co(III)H intermediate to Co(II)H, which is then protonated by acid to generate H2. A bridge-protonated Co(I) species was ruled out as a catalytic intermediate for Co(II)(dmgBF2)2(CH3CN)2 from voltammograms recorded at 1000 psi of H2. Density functional theory was used to calculate Co(III)-H and Co(II)-H bond strengths for both catalysts. Despite having very different ligands, the cobalt hydrides of both catalysts possess nearly identical heterolytic and homolytic Co-H bond strengths for the Co(III)H and Co(II)H intermediates.

  4. Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro. (United States)

    Puntel, Robson L; Nogueira, Cristina W; Rocha, João B T


    The aim of this study was to investigate the effect of Krebs cycle intermediates on basal and quinolinic acid (QA)- or iron-induced TBARS production in brain membranes. Oxaloacetate, citrate, succinate and malate reduced significantly the basal and QA-induced TBARS production. The potency for basal TBARS inhibition was in the order (IC50 is given in parenthesis as mM) citrate (0.37) > oxaloacetate (1.33) = succinate (1.91) > > malate (12.74). alpha-Ketoglutarate caused an increase in TBARS production without modifying the QA-induced TBARS production. Cyanide (CN-) did not modify the basal or QA-induced TBARS production; however, CN- abolished the antioxidant effects of succinate. QA-induced TBARS production was enhanced by iron ions, and abolished by desferrioxamine (DFO). The intermediates used in this study, except for alpha-ketoglutarate, prevented iron-induced TBARS production. Oxaloacetate, citrate, alpha-ketoglutarate and malate, but no succinate and QA, exhibited significantly iron-chelating properties. Only alpha-ketoglutarate and oxaloacetate protected against hydrogen peroxide-induced deoxyribose degradation, while succinate and malate showed a modest effect against Fe2+/H2O2-induced deoxyribose degradation. Using heat-treated preparations citrate, malate and oxaloacetate protected against basal or QA-induced TBARS production, whereas alpha-ketoglutarate induced TBARS production. Succinate did not offer protection against basal or QA-induced TBARS production. These results suggest that oxaloacetate, malate, succinate, and citrate are effective antioxidants against basal and iron or QA-induced TBARS production, while alpha-ketoglutarate stimulates TBARS production. The mechanism through which Krebs cycle intermediates offer protection against TBARS production is distinct depending on the intermediate used. Thus, under pathological conditions such as ischemia, where citrate concentrations vary it can assume an important role as a modulator of oxidative

  5. Intermediate mass dilepton production during the chemical equilibration of quark gluon plasma

    Institute of Scientific and Technical Information of China (English)


    The production of dileptons from the chemically equilibrating quark gluon plasma in the intermediate mass region has been studied. Comparing with the calculated results based on the thermodynamic equilibrium system of quark gluon plasma, it has been found that the quark phase of the chemically equilibrating system gives rise to an even larger enhancement of the dileptons production. Therefore, such an enhancement of dilepton production may signal the formation of quark gluon plasma.

  6. Intermediate Mass Dilepton Production in a Chemically Equilibrating Quark-Gluon Matter

    Institute of Scientific and Technical Information of China (English)

    HE Ze-Jun; ZHOU Wen-Jie; ZHANG Jia-Ju; LIU Bo


    Dilepton production during the chemical equilibration of quark-gluon matter with a finite baryon density has been studied. We find that due to the slowing down of the cooling rate and the high initial temperature of the quark-gluon matter produced at RHIC energies, the quark phase contribution to dileptons with intermediate masses is significantly heightened and is much larger than that calculated by the evolution of the thermodynamic equilibrium system. The latter has shown an enhancement of intermediate mass dileptons from the quark phase. Therefore, such an enhancement of dileptons should be a signature for quark-gluon matter formation.

  7. Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate

    DEFF Research Database (Denmark)

    Christensen, Kim Müller; Pedersen, Michael Jønch; Dam-Johansen, Kim;


    A novel filter reactor system for continuous production of selected pharmaceutical intermediates is presented and experimentally verified. The filter reactor system consists of a mixed flow reactor equipped with a bottom filter, to retain solid reactant particles, followed by a conventional plug...... flow reactor, where residual reactant is converted by titration. A chemical case study, production of the pharmaceutical intermediate allylcarbinol by a reaction between allylmagnesium chloride and 2-chloro-thioxanthone, in the presence of a side reaction is considered. The synthesis is conducted......-batch operation, are reduced impurity formation and the use of much lower reactor volumes (factor of 1000 based on the laboratory reactor) and less solvent consumption (from 5.8 to 2.3L/kg reactant). Added challenges include handling of continuous solid powder feeding, stable pumping of reactive slurries...

  8. Characterization of intermediate products of solar photocatalytic degradation of ranitidine at pilot-scale. (United States)

    Radjenović, Jelena; Sirtori, Carla; Petrović, Mira; Barceló, Damià; Malato, Sixto


    In the present study the mechanisms of solar photodegradation of H(2)-receptor antagonist ranitidine (RNTD) were studied in a well-defined system of a pilot plant scale Compound Parabolic Collector (CPC) reactor. Two types of heterogeneous photocatalytic experiments were performed: catalysed by titanium-dioxide (TiO(2)) semiconductor and by Fenton reagent (Fe(2+)/H(2)O(2)), each one with distilled water and synthetic wastewater effluent matrix. Complete disappearance of the parent compounds and discreet mineralization were attained in all experiments. Furthermore, kinetic parameters, main intermediate products, release of heteroatoms and formation of carboxylic acids are discussed. The main intermediate products of photocatalytic degradation of RNTD have been structurally elucidated by tandem mass spectrometry (MS(2)) experiments performed at quadrupole-time of flight (QqToF) mass analyzer coupled to ultra-performance liquid chromatograph (UPLC). RNTD displayed high reactivity towards OH radicals, although a product of conduction band electrons reduction was also present in the experiment with TiO(2). In the absence of standards, quantification of intermediates was not possible and only qualitative profiles of their evolution could be determined. The proposed TiO(2) and photo-Fenton degradation routes of RNTD are reported for the first time.

  9. Communication: Real time observation of unimolecular decay of Criegee intermediates to OH radical products (United States)

    Fang, Yi; Liu, Fang; Barber, Victoria P.; Klippenstein, Stephen J.; McCoy, Anne B.; Lester, Marsha I.


    In the atmosphere, a dominant loss process for carbonyl oxide intermediates produced from alkene ozonolysis is also an important source of hydroxyl radicals. The rate of appearance of OH radicals is revealed through direct time-domain measurements following vibrational activation of prototypical methyl-substituted Criegee intermediates under collision-free conditions. Complementary theoretical calculations predict the unimolecular decay rate for the Criegee intermediates in the vicinity of the barrier for 1,4 hydrogen transfer that leads to OH products. Both experiment and theory yield unimolecular decay rates of ca. 108 and 107 s-1 for syn-CH3CHOO and (CH3)2COO, respectively, at energies near the barrier. Tunneling through the barrier, computed from high level electronic structure theory and experimentally validated, makes a significant contribution to the decay rate. Extension to thermally averaged unimolecular decay of stabilized Criegee intermediates under atmospheric conditions yields rates that are six orders of magnitude slower than those evaluated directly in the barrier region.

  10. Electrochemical Detection of Transient Cobalt Hydride Intermediates of Electrocatalytic Hydrogen Production

    Energy Technology Data Exchange (ETDEWEB)

    Wiedner, Eric S.; Bullock, R. Morris


    We report the use of variable scan rate cyclic voltammetry to detect transient CoIIIH and CoIIH intermediates of electrocatalytic H2 production by CoII(dmgBF2)2(CH3CN)2 and [CoII(PtBu2NPh2)(CH3CN)3]2+. In both cases, reduction of the CoIIIH intermediate was observed to coincide with the CoII/I couple, and the resulting CoIIH intermediate is protonated by acid to afford H2. Our studies indicate that in electrocatalytic H2 production, protonation of CoIIH is rate-limiting for CoII(dmgBF2)2(CH3CN)2, and protonation of CoI is rate-limiting for [CoII(PtBu2NPh2)(CH3CN)3]2+. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.

  11. Choosing Your Medical Specialty (United States)

    ... AMA provides to help members save money. Residency & Career Planning Find resources for a range of medical career ... Fellowships Back to top Home Life & Career Residency & Career Planning Choosing a Medical Specialty Back to top Choosing ...

  12. Effect of intermediate compounds and products on wet oxidation and biodegradation rates of pharmaceutical compounds. (United States)

    Collado, Sergio; Laca, Adriana; Diaz, Mario


    Kinetics of pure compounds in batch agitated reactors are useful data to clarify the characteristics of a given reaction, but they frequently do not provide the required information to design industrial mixed continuous processes because in this case the final and intermediate products interact with the reaction of interest, due to backmixing effects. Simultaneously, the presence and transformations of other compounds, frequent in industrial wastewater treatments, adds more complexity to these types of interactions, whose effect can be different, favorable or unfavorable, for chemical or biological reactions. In this work, batch laboratory reactor data were obtained for the wet oxidation and biodegradation of four phenolic compounds present in a pharmaceutical wastewater and then compared with those collected from industrial continuous stirred tank reactors. For wet oxidation, batch laboratory degradation rates were significantly lower than those found in industrial continuous stirred operation. This behavior was explained by a different distribution of intermediate compounds in lab and industrial treatments, caused by the degree of backmixing and the synergistic effects between phenolic compounds (matrix effects). On the other hand, the specific utilization rates during aerobic biodegradation in the continuous industrial operation were lower than those measured in the laboratory, due to the simultaneous presence of the four pollutants in the industrial process (matrix effects) increasing the inhibitory effects of these compounds and its intermediates.

  13. Modeling intermediate product selection under production and storage capacity limitations in food processing

    DEFF Research Database (Denmark)

    Kilic, Onur Alper; Akkerman, Renzo; Grunow, Martin;


    and processing costs are minimized. However, this product selection process is bound by production and storage capacity limitations, such as the number and size of storage tanks or silos. In this paper, we present a mathematical programming approach that combines decision making on product selection...

  14. Make or mix to order: Determining the type of intermediate products in a flour mill

    DEFF Research Database (Denmark)

    Akkerman, Renzo; van der Meer, Dirk; van Donk, Dirk Pieter


    be made not only with regard to where to store, but also what to store, which is currently not covered in Decoupling Point (DP) theory. This paper explores this joint problem for a flour mill. The number and type of intermediate products in the DP is determined using a two-stage mathematical program....... The model facilitates decision-making for the management of the mill regarding what to store, but is also useful to support decisions for capacity increase or investments in storage tanks. We also contribute to DP theory in developing a quantitative tool tailored to food processing characteristics....

  15. Choosing co-substrates to supplement biogas production from animal slurry - A life cycle assessment of the environmental consequences

    DEFF Research Database (Denmark)

    Croxatto Vega, Giovanna Catalina; Ten Hoeve, Marieke; Birkved, Morten


    nutrient content and high methane potential, straw yields the lowest impacts for eutrophication and the highest climate change and fossil depletion savings. Co-substrates diverted from incineration to biogas production had fewer environmental benefits, due to the loss of energy production, which...... is then produced from conventional fossil fuels. The scenarios can often provide benefits for one impact category while causing impacts in another.......Biogas production from animal slurry can provide substantial contributions to reach renewable energy targets, yet due to the low methane potential of slurry, biogas plants depend on the addition of co-substrates to make operations profitable. The environmental performance of three underexploited co...

  16. Effects of lactone, ketone, and phenolic compounds on methane production and metabolic intermediates during anaerobic digestion. (United States)

    Wikandari, Rachma; Sari, Noor Kartika; A'yun, Qurrotul; Millati, Ria; Cahyanto, Muhammad Nur; Niklasson, Claes; Taherzadeh, Mohammad J


    Fruit waste is a potential feedstock for biogas production. However, the presence of fruit flavors that have antimicrobial activity is a challenge for biogas production. Lactones, ketones, and phenolic compounds are among the several groups of fruit flavors that are present in many fruits. This work aimed to investigate the effects of two lactones, i.e., γ-hexalactone and γ-decalactone; two ketones, i.e., furaneol and mesifurane; and two phenolic compounds, i.e., quercetin and epicatechin on anaerobic digestion with a focus on methane production, biogas composition, and metabolic intermediates. Anaerobic digestion was performed in a batch glass digester incubated at 55 °C for 30 days. The flavor compounds were added at concentrations of 0.05, 0.5, and 5 g/L. The results show that the addition of γ-decalactone, quercetin, and epicathechin in the range of 0.5-5 g/L reduced the methane production by 50 % (MIC50). Methane content was reduced by 90 % with the addition of 5 g/L of γ-decalactone, quercetin, and epicathechin. Accumulation of acetic acid, together with an increase in carbon dioxide production, was observed. On the contrary, γ-hexalactone, furaneol, and mesifurane increased the methane production by 83-132 % at a concentration of 5 g/L.

  17. Biological Production of a Hydrocarbon Fuel Intermediate Polyhydroxybutyrate (Phb) from a Process Relevant Lignocellulosic Derived Sugar

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wei; Mohagheghi, Ali; Mittal, Ashutosh; Pilath, Heidi; Johnson, David K.


    PHAs are synthesized by many microorganisms to serve as intracellular carbon storage molecules. In some bacterial strains, PHB can account for up to 80% of cell mass. In addition to its application in the packaging sector, PHB also has great potential as an intermediate in the production of hydrocarbon fuels. PHB can be thermally depolymerized and decarboxylated to propene which can be upgraded to hydrocarbon fuels via commercial oligomerization technologies. In recent years a great effort has been made in bacterial production of PHB, yet the production cost of the polymer is still much higher than conventional petrochemical plastics. The high cost of PHB is because the cost of the substrates can account for as much as half of the total product cost in large scale fermentation. Thus searching for cheaper and better substrates is very necessary for PHB production. In this study, we demonstrate production of PHB by Cupriavidus necator from a process relevant lignocellulosic derived sugar stream, i.e., saccharified hydrolysate slurry from pretreated corn stover. Good cell growth was observed on slurry saccharified with advanced enzymes and 40~60% of PHB was accumulated in the cells. The mechanism of inhibition in the toxic hydrolysate generated by pretreatment and saccharification of biomass, will be discussed.

  18. Choosing co-substrates to supplement biogas production from animal slurry--a life cycle assessment of the environmental consequences. (United States)

    Croxatto Vega, Giovanna Catalina; ten Hoeve, Marieke; Birkved, Morten; Sommer, Sven G; Bruun, Sander


    Biogas production from animal slurry can provide substantial contributions to reach renewable energy targets, yet due to the low methane potential of slurry, biogas plants depend on the addition of co-substrates to make operations profitable. The environmental performance of three underexploited co-substrates, straw, organic household waste and the solid fraction of separated slurry, were assessed against slurry management without biogas production, using LCA methodology. The analysis showed straw, which would have been left on arable fields, to be an environmentally superior co-substrate. Due to its low nutrient content and high methane potential, straw yields the lowest impacts for eutrophication and the highest climate change and fossil depletion savings. Co-substrates diverted from incineration to biogas production had fewer environmental benefits, due to the loss of energy production, which is then produced from conventional fossil fuels. The scenarios can often provide benefits for one impact category while causing impacts in another.

  19. Climate, productivity, and intermediate water nutrients: new records from bamboo coral Ba/Ca (United States)

    Lavigne, M.; Hill, T. M.; Spero, H. J.; Guilderson, T. P.


    A geochemical nutrient proxy from deep-sea corals would provide decadal to centennial scale records of intermediate-water nutrient dynamics. Such records could be used to determine how intermediate water masses (300-2000m) are affected by decadal scale climate change (e.g. Pacific Decadal Oscillation) via carbon cycling, export production, and intermediate water-mass circulation/ventilation. Because seawater barium (BaSW ) has a nutrient-like distribution in the water-column (similar to silicate), Ba/Ca records have been used to trace upwelled nutrient supply in shallow water surface corals isolated from terrestrial barium sources. Here we show the first calibration of a nutrient proxy from skeletal barium preserved in the calcitic internodes of bamboo corals. Our calibration was calculated from a depth transect (500-2000m) of Isidella and Keratoisis corals spanning a silicate and (BaSW ) gradient on the California Margin (Ba/Ca coral (µmol/mol) = 0.117 BaSW (nmol/kg ) + 0.835; R2 = 0.88; n = 29). The strong linear correlation between Ba/Ca coral and BaSW suggests that coral Ba/Ca is a reliable recorder of seawater barium (and, therefore, silicate). We find a distribution coefficient (DBa) for bamboo coral Ba/Ca of 1.3±0.1, similar to that of other corals (surface and deep-sea dwelling) and inorganic calcium carbonate precipitation experiments (DBa = 1.2-1.5). This implies that, as true for other carbonates, Ba incorporation is primarily driven by ionic substitution and holds promise as a globally applicable nutrient proxy in bamboo corals. High-resolution Ba/Ca timeseries records sampled via LA-ICP-MS in two co-located California Margin corals (Pioneer Seamount; 830m; 37°22’27”N) co-vary with ~decadal-scale variations in silicate and nitrate measured at 500m depth (CalCOFI line 80 sta. 60; 34°8’60”N). This suggests that high-resolution records of bamboo coral Ba/Ca can be used to reconstruct broad changes in intermediate water nutrients driven by

  20. To Choose or Not to Choose Science

    DEFF Research Database (Denmark)

    Holmegaard, Henriette Tolstrup; Madsen, Lene Møller; Ulriksen, Lars


    In the literature, there is a general concern that a less number of students choose to study science, technology, engineering or mathematics (STEM). This paper presents results from a Danish longitudinal study which examines students’ choice of whether or not to continue studying STEM after upper...


    Directory of Open Access Journals (Sweden)

    A. N. Pal’chikov


    Full Text Available The following article is devoted to the new technical facilities for food production, which technological chain of production process includes computer hardware as a part of the equipment used for body of semi-processed food preparation, blancher for hydrobionts and abrasive blender. For the whole group of the necessary equipment the principal schemes are designed, and the abrasive blender was tested during the experimental approbation to reveal the optimal design. The culinary fish pastes have already been produced in the enterprises in many countries for many years and they are particularly popular in Japan, Germany, Scandinavian and other country. In Poland the mixtures of fish pasted have become widely spread, and are used for production of portioned meals. These pastes may be blended into larger or smaller pieces. The aromatization process of such pastes is conducted with adding the liquid smoke, natural or synthetic fragrances. There is an increasing popularization of the use of flaxseed as a source of alpha-linoleic acid, high-quality protein, phenolics, fiber and minerals. Products with flax meal can be recommended for inclusion in the diet to make up for the deficit of polyunsaturated fatty acids, dietary fiber. In this regard, it is appropriate to use the semi-finished product formulations for the respective housings extruded snack food. The results of the conducted research could be used in the production of domestic extruded snacks, which have the form of the cushions with vitaminized dough body and hydrobionts stuffing if setting the special extrusion modes.

  2. Cherenkov light detection as a velocity selector for uranium fission products at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, T., E-mail: [Department of Physics, Saitama University, Saitama 338-8570 (Japan); Enomoto, A.; Kouno, J.; Yamaki, S.; Matsunaga, S.; Suzaki, F.; Suzuki, T. [Department of Physics, Saitama University, Saitama 338-8570 (Japan); Abe, Y.; Nagae, D.; Okada, S.; Ozawa, A.; Saito, Y.; Sawahata, K. [Institute of Physics, University of Tsukuba, Ibaraki 305-8571 (Japan); Kitagawa, A.; Sato, S. [National Institute of Radiological Sciences, Chiba 263-8555 (Japan)


    The in-flight particle separation capability of intermediate-energy radioactive ion (RI) beams produced at a fragment separator can be improved with the Cherenkov light detection technique. The cone angle of Cherenkov light emission varies as a function of beam velocity. This can be exploited as a velocity selector for secondary beams. Using heavy ion beams available at the HIMAC synchrotron facility, the Cherenkov light angular distribution was measured for several thin radiators with high refractive indices (n=1.9∼2.1). A velocity resolution of ∼10{sup −3} was achieved for a {sup 56}Fe beam with an energy of 500 MeV/nucleon. Combined with the conventional rigidity selection technique coupled with energy-loss analysis, the present method will enable the efficient selection of an exotic species from huge amounts of various nuclides, such as uranium fission products at the BigRIPS fragment separator located at the RI Beam Factory. - Highlights: • The cone angle of Cherenkov light can be used as a velocity selector of RI beams. • Proof-of-principle experiments are made using heavy ions at intermediate energies. • Results demonstrate successful separation of RI beams produced by fragmentation. • A velocity resolution of 10{sup −3} is achieved for thin high refractive radiators.

  3. Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase. (United States)

    Broussard, Tyler C; Pakhomova, Svetlana; Neau, David B; Bonnot, Ross; Waldrop, Grover L


    Acetyl-CoA carboxylase catalyzes the first and regulated step in fatty acid synthesis. In most Gram-negative and Gram-positive bacteria, the enzyme is composed of three proteins: biotin carboxylase, a biotin carboxyl carrier protein (BCCP), and carboxyltransferase. The reaction mechanism involves two half-reactions with biotin carboxylase catalyzing the ATP-dependent carboxylation of biotin-BCCP in the first reaction. In the second reaction, carboxyltransferase catalyzes the transfer of the carboxyl group from biotin-BCCP to acetyl-CoA to form malonyl-CoA. In this report, high-resolution crystal structures of biotin carboxylase from Haemophilus influenzae were determined with bicarbonate, the ATP analogue AMPPCP; the carboxyphosphate intermediate analogues, phosphonoacetamide and phosphonoformate; the products ADP and phosphate; and the carboxybiotin analogue N1'-methoxycarbonyl biotin methyl ester. The structures have a common theme in that bicarbonate, phosphate, and the methyl ester of the carboxyl group of N1'-methoxycarbonyl biotin methyl ester all bound in the same pocket in the active site of biotin carboxylase and as such utilize the same set of amino acids for binding. This finding suggests a catalytic mechanism for biotin carboxylase in which the binding pocket that binds tetrahedral phosphate also accommodates and stabilizes a tetrahedral dianionic transition state resulting from direct transfer of CO₂ from the carboxyphosphate intermediate to biotin.

  4. Stability of A Coevolving Host-parasite System Peaks at Intermediate Productivity (United States)

    Zhao, Xin-Feng; Hao, Yi-Qi; Zhang, Quan-Guo


    Habitat productivity may affect the stability of consumer-resource systems, through both ecological and evolutionary mechanisms. We hypothesize that coevolving consumer-resource systems show more stable dynamics at intermediate resource availability, while very low-level resource supply cannot support sufficiently large populations of resource and consumer species to avoid stochastic extinction, and extremely resource-rich environments may promote escalatory arms-race-like coevolution that can cause strong fluctuations in species abundance and even extinction of one or both trophic levels. We tested these ideas by carrying out an experimental evolution study with a model bacterium-phage system (Pseudomonas fluorescens SBW25 and its phage SBW25Φ2). Consistent with our hypothesis, this system was most stable at intermediate resource supply (fewer extinction events and smaller magnitude of population fluctuation). In our experiment, the rate of coevolution between bacterial resistance and phage infectivity was correlated with the magnitude of population fluctuation, which may explain the different in stability between levels of resource supply. Crucially, our results are consistent with a suggestion that, among the two major modes of antagonistic coevolution, arms race is more likely than fluctuation selection dynamics to cause extinction events in consumer-resource systems. This study suggests an important role of environment-dependent coevolutionary dynamics for the stability of consumer-resource species systems, therefore highlights the importance to consider contemporaneous evolutionary dynamics when studying the stability of ecosystems, particularly those under environmental changes. PMID:28076419

  5. Complex fragment production in Kr-induced reactions at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Adorno, A.; Colonna, M.; Di Toro, M. (Catania Univ. (Italy). Dipt. di Fisica INFN, Catania (Italy). Lab. Nazionale del Sud); Bonasera, A. (INFN, Catania (Italy)); Cavinato, M.; Gulminelli, F. (Milan Univ. (Italy). Dipt. di Fisica INFN, Milan (Italy)); Cunsolo, A. (Catania Univ. (Italy). Dipt. di Fisica INFN, Catania (Italy)); Di Leo, G.C. (Catania Univ. (Italy). Dipt. di Fisica)


    Several features of complex fragment production at intermediate energies can be understood from the coupling of a dynamical description, which takes into account entrance-channel properties, and a statistical decay of equilibrated primary sources. We discuss this point using two different models for the dynamics, both based on the idea of the competition between mean field and two-body effects in this intermediate-energy range. The importance of a slow emission of large clusters in the de-excitation stage is stressed, with the possibility of using a suitably extended evaporation code. Fragment yields and spectra are analysed for Kr-induced reactions on C, Al, Ti at 34.4 MeV/A and on Au at 43 MeV/A. The effects of a different equation of state (e.o.s.) used in microscopic calculations is analysed. A stiffer e.o.s. implies more stopping of the fragments. Finally, projectile-like fragments produced in the Kr+Au reaction at 200 MeV/A are analysed. The predictions of the participant-spectator model are confirmed in this energy range. (orig.).

  6. Characterization of surface dielectric barrier discharge influenced by intermediate frequency for ozone production (United States)

    Abdelaziz, Ayman A.; Ishijima, Tatsuo; Seto, Takafumi; Osawa, Naoki; Wedaa, Hassan; Otani, Yoshio


    The aim of this study is to investigate the effect of the intermediate frequency (1-10 kHz) of the sinusoidal driving voltage on the characteristics of a developed surface dielectric barrier discharge (SDBD)-based reactor having spikes on its discharge electrode. Moreover, its influence on the production of ozone and nitrogen oxide byproducts is evaluated. The results show that SDBD is operated in the filamentary mode at all the frequencies. Nevertheless, the pulses of the discharge current at high frequencies are much denser and have higher amplitudes than those at low frequencies. The analysis of the power consumed in the reactor shows that a small portion of the input power is dissipated in the dielectric material of SDBD source, whereas the major part of the power is consumed in the plasma discharge. The results of the ozone production show that higher frequencies have a slightly adverse effect on the ozone production at relatively high energy density values, where the ozone concentration is slightly decreased when the frequency is increased at the same energy density. The temperature of the discharge channels and gas is not a crucial factor for the decomposition of ozone in this reactor, while the results of the measurements of nitrogen oxides characteristics indicate that the formation of NO and NO2 has a significant adverse effect on the production efficiency of ozone due to their oxidation to another nitrogen oxides and their catalytic effect.

  7. Cherenkov light detection as a velocity selector for uranium fission products at intermediate energies (United States)

    Yamaguchi, T.; Enomoto, A.; Kouno, J.; Yamaki, S.; Matsunaga, S.; Suzaki, F.; Suzuki, T.; Abe, Y.; Nagae, D.; Okada, S.; Ozawa, A.; Saito, Y.; Sawahata, K.; Kitagawa, A.; Sato, S.


    The in-flight particle separation capability of intermediate-energy radioactive ion (RI) beams produced at a fragment separator can be improved with the Cherenkov light detection technique. The cone angle of Cherenkov light emission varies as a function of beam velocity. This can be exploited as a velocity selector for secondary beams. Using heavy ion beams available at the HIMAC synchrotron facility, the Cherenkov light angular distribution was measured for several thin radiators with high refractive indices (n = 1.9 ~ 2.1). A velocity resolution of ~10-3 was achieved for a 56Fe beam with an energy of 500 MeV/nucleon. Combined with the conventional rigidity selection technique coupled with energy-loss analysis, the present method will enable the efficient selection of an exotic species from huge amounts of various nuclides, such as uranium fission products at the BigRIPS fragment separator located at the RI Beam Factory.

  8. Intermediate mass dilepton production in a chemically equilibrating quark-gluon matter

    Institute of Scientific and Technical Information of China (English)


    We find that in a chemically equilibrating baryon-rich quark-gluon matter, due to the slow cooling rate, high initial temperature, large gluon density as well as large fusion cross section ofin the intermediate mass region, the gluon fusion provides a dominant contribution to dileptons with intermediate masses, resulting in the significant enhancement of intermediate mass dileptons.

  9. Communal nursing in wild house mice is not a by-product of group living: Females choose (United States)

    Weidt, Andrea; Lindholm, Anna K.; König, Barbara


    Communal nursing, the provision of milk to non-offspring, has been argued to be a non-adaptive by-product of group living. We used 2 years of field data from a wild house mouse population to investigate this question. Communal nursing never occurred among females that previously lacked overlap in nest box use. Females nursed communally in only 33 % of cases in which there was a communal nursing partner available from the same social group. Solitarily nursing females were not socially isolated in their group; nevertheless, high spatial associations prior to reproduction predict which potential female partner was chosen for communal nursing. An increase in partner availability increased the probability of communal nursing, but population density itself had a negative effect, which may reflect increased female reproductive competition during summer. These results argue that females are selective in their choice of nursing partners and provide further support that communal nursing with the right partner is adaptive.

  10. Choosing the best pulse sequences, acquisition parameters, postacquisition processing strategies, and probes for natural product structure elucidation by NMR spectroscopy. (United States)

    Reynolds, William F; Enríquez, Raúl G


    The relative merits of different pairs of two-dimensional NMR pulse sequences (COSY-90 vs COSY-45, NOESY vs T-ROESY, HSQC vs HMQC, HMBC vs CIGAR, etc.) are compared and recommendations are made for the preferred choice of sequences for natural product structure elucidation. Similar comparisons are made between different selective 1D sequences and the corresponding 2D sequences. Many users of 2D NMR use longer than necessary relaxation delays and neglect to use forward linear prediction processing. It is shown that using shorter relaxation delays in combination with forward linear prediction allows one to get better resolved spectra in less time. The relative merits of different probes and likely future probe developments are also discussed.

  11. Study of intermediate velocity products in the Ar + Ni collisions between 52 and 95 A.MeV

    CERN Document Server

    Lefort, T; Cussol, D; Ma, Y G; Péter, J; Dayras, R; Assenard, M; Auger, G; Bacri, C O; Bocage, F; Bougault, R; Brou, R; Buchet, P; Charvet, J L; Chbihi, A; Colin, J; Demeyer, A N; Durand, D; Eudes, P; Frankland, J D; Galíchet, E; Genouin-Duhamel, E; Gerlic, E; Germain, M; Gourio, D; Guinet, D; Hurst, B; Lautesse, P; Laville, J L; Lecolley, J F; Lefèvre, A; Legrain, R; Le Neindre, N; López, O; Louvel, M; Maskay, A M; Nalpas, L; Nguyen, A D; Pârlog, M; Plagnol, E; Politi, G; Rahmani, A; Reposeur, T; Rosato, E; Saint-Laurent, F; Salou, S; Steckmeyer, J C; Stern, M; Tabacaru, G; Tamain, B; Tassan-Got, L; Tirel, O; Vient, E; Volant, C; Wieleczko, J P; Wieloch, A


    Intermediate velocity products in Ar+Ni collisions from 52 to 95 A.MeV are studied in an experiment performed at the GANIL facility with the 4$\\pi$ multidetector INDRA. It is shown that these emissions cannot be explained by statistical decays of the quasi-projectile and the quasi-target in complete equilibrium. Three methods are used to isolate and characterize intermediate velocity products. The total mass of these products increases with the violence of the collision and reaches a large fraction of the system mass in mid-central collisions. This mass is found independent of the incident energy, but strongly dependent on the geometry of the collision. Finally it is shown that the kinematical characteristics of intermediate velocity products are weakly dependent on the experimental impact parameter, but strongly dependent on the incident energy. The observed trends are consistent with a participant-spectator like scenario or with neck emissions and/or break-up.

  12. Slow and fast pyrolysis of Douglas-fir lignin: Importance of liquid-intermediate formation on the distribution of products

    NARCIS (Netherlands)

    Zhou, Shuai; Pecha, Brennan; Kuppevelt, van Michiel; McDonald, Armando G.; Garcia-Perez, Manuel


    The formation of liquid intermediates and the distribution of products were studied under slow and fast pyrolysis conditions. Results indicate that monomers are formed from lignin oligomeric products during secondary reactions, rather than directly from the native lignin. Lignin from Douglas-fir (Ps

  13. To Choose or Not to Choose Science

    DEFF Research Database (Denmark)

    Holmegaard, Henriette Tolstrup; Madsen, Lene Møller; Ulriksen, Lars


    In the literature, there is a general concern that a less number of students choose to study science, technology, engineering or mathematics (STEM). This paper presents results from a Danish longitudinal study which examines students’ choice of whether or not to continue studying STEM after upper......-secondary school. In particular, this study focuses on students who held an STEM subject as one of their favourite subjects at secondary educational level, but who chose not to study STEM at the tertiary level. This paper explores how students’ perceptions of STEM relate to their identity work. The data used...


    Directory of Open Access Journals (Sweden)

    I. I. Zelepukin


    Full Text Available Summary. Applicable for sulfitation equipment should provide a high degree of utilization of sulfur dioxide, which should allow to reduce the cost of production of sugar by reducing fuel sulfur and improve the ecological situation in the placement of a sugar factory. Currently used as standard equipment the liquid-jet sulfitator type A2-PSK and A2-PSM have disadvantages, the main ones are: unsatisfactory performance when the flow solution to be treated and released into the atmosphere from the combustion products nutritionally sulfur. Modernized standard liquid spray sulfitator to improve performance without significant cost, even if the treated liquid flow. A positive result with this work sulfitator achieved due to the fact that the mixing chamber is provided with a device for controlling the flow cross section of holes disc formed as it moves in the ring attached thereto with tapered fingers. Sulfitator is a cylindrical body provided with a sulfited separator for separating liquid and flue gas. By using a separator attached flange connection mixing chamber sulfitation source liquid and a gas supply pipe provided with sulfur dioxide placed inside a disk having five openings for forming jets of high dynamic fluid flow control device and a disk hole section formed in a chamber in the movable ring attached to it, tapered fingers. The form allows the fingers to create a flow of fluid through the disc hole, flowing at high speed and maintain a constant positive pressure to drive the liquid in the mixing chamber. When changing the amount of fluid supplied to the sulfitation ring having tapered fingers moves the fingers and alter the orifice holes, maintaining the pressure of the sugar solution prior to manufacturing the disk constant. This improves the contact of the liquid with the gas. The designed device can improve the efficiency of physical and chemical treatment of liquid intermediates of sugar production.


    Directory of Open Access Journals (Sweden)



    Full Text Available Human existence is conditioned, of course, by the consumption of goods to meet the needs. Using the property to obtain other goods in this way is not consumption, but production. Goods that are the object of consumption can be natural or economic (created or produced by man. The natural goods that we can find in the human consumption, even if there are extremely important, there are not the subject of our attention because they are a gift of nature. In economics, the effect that a good is predicted to have during or after it is consumed is designated by the term of utility. In the context of a severe economic crisis, which determines a real sacrifice of consumer’s wishes, under the impact of budgetary constraint, the utility and the consumer optimum suffer various modifications.Increasingly limited resources and low incomes lead to more people sacrifices concerning the goods that they will consume, respectively purchase. So we consume less, we produce less, causing a reduction in GDP. The economical crisis, through its effects has changed the people consumption habitudes by editing it according to the available resources. Manufacturers, in the absence of profits will be forced to find new solutions to attract consumers.The main objective of this paper is to highlight the relationship that exists between the consumption, goods and services production and GDP. In terms of economics, the goods and services production and intermediate consumption directly influence GDP, as two independent variables and dependent GDP. We performed a simple regression model based on a series of data in Romania, during 1995-2009, to evidence the importance of the two independent variables in obtaining an increased GDP.

  16. Self-Repair in Oral Production by Intermediate Chinese Learners of English (United States)

    Liu, Jiangtao


    For various reasons, second language learners modify their speech by means of self-repair. This study, based on a small-scale corpus, shows the patterns and features of self-repairs by intermediate Chinese learners of English. The results suggest that intermediate Chinese learners of English more frequently make repairs than advanced Chinese…

  17. Structures of aminophenol dioxygenase in complex with intermediate, product and inhibitor. (United States)

    Li, De Feng; Zhang, Jia Yue; Hou, Yan Jie; Liu, Lei; Hu, Yonglin; Liu, Shuang Jiang; Wang, Da Cheng; Liu, Wei


    Dioxygen activation by nonhaem Fe(II) enzymes containing the 2-His-1-carboxylate facial triad has been extensively studied in recent years. Here, crystal structures of 2-aminophenol 1,6-dioxygenase, an enzyme that represents a minor group of extradiol dioxygenases and that catalyses the ring opening of 2-aminophenol, in complex with the lactone intermediate (4Z,6Z)-3-iminooxepin-2(3H)-one and the product 2-aminomuconic 6-semialdehyde and in complex with the suicide inhibitor 4-nitrocatechol are reported. The Fe-ligand binding schemes observed in these structures revealed some common geometrical characteristics that are shared by the published structures of extradiol dioxygenases, suggesting that enzymes that catalyse the oxidation of noncatecholic compounds are very likely to utilize a similar strategy for dioxygen activation and the fission of aromatic rings as the canonical mechanism. The Fe-ligation arrangement, however, is strikingly enantiomeric to that of all other 2-His-1-carboxylate enzymes apart from protocatechuate 4,5-dioxygenase. This structural variance leads to the generation of an uncommon O(-)-Fe(2+)-O(-) species prior to O(2) binding, which probably forms the structural basis on which APD distinguishes its specific substrate and inhibitor, which share an analogous molecular structure.

  18. Intermediate and product storage systems for the JET active gas handling system - inactive commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Stagg, R.; Hemmerich, J.L.; Lasser, R.; Laveyry, M.; Lupo, J.; Milverton, P.; Skinner, N.; Perevezentsev, A. [JET Joint Undertaking, Oxfordshire (United Kingdom)


    The Product Storage (PS) and Intermediate Storage (IS) systems of the Active Gas Handling System (AGHS) are hydrogen isotope storage facilities. IS will take pure hydrogen mixtures from the Cryogenic Forevacuum (CF) system and store them until the isotope separation systems, Cryogenic Distillation (CD) and Gas Chromatography (GC), are ready to separate the mixtures into pure H{sub 2}, D{sub 2} and T{sub 2}. The purified D{sub 2} and T{sub 2} will be sent to PS for storage, while any protium will be diluted with nitrogen and discharged to atmosphere if the T{sub 2} levels are below 4 x 10{sup -4}Ci/m{sup 3}. PS will then deliver gas via the Gas Introduction (GI) system to the various users. The principal parts of PS and IS are their U-bed assemblies. Each assembly consists of four uranium beds (U-bed) which each store up to 27 moles of hydrogen. The commissioning results, the absorption and desorption characteristics of the U-beds, the sequences for safe operation of the U-beds and transfer of gases to other AGHS systems, the hardwired interlock system and the over/underpressure protection system for the secondary containments will be discussed. 8 refs., 4 figs.

  19. Crystal Structures of Fe2+ Dioxygenase Superoxo, Alkylperoxo, and Bound Product Intermediates


    Kovaleva, Elena G.; Lipscomb, John D.


    We report the structures of three intermediates in the O2 activation and insertion reactions of an extradiol ring-cleaving dioxygenase. A crystal of Fe2+-containing homoprotocatechuate 2,3-dioxygenase was soaked in the slow substrate 4-nitrocatechol in a low O2 atmosphere. The X-ray crystal structure shows that three different intermediates reside in different subunits of a single homotetrameric enzyme molecule. One of these is the key substrate-alkylperoxo-Fe2+ intermediate, which has been p...

  20. Results of incorporating recommendations on designing and choosing efficient forms of structural supports for the development workings at the ''Primorskugol'' production union mines

    Energy Technology Data Exchange (ETDEWEB)

    Shirokov, A.P.; Kuntsevich, V.I.; Pisliakov, V.G.


    Results are given from research on developing and incorporating methodology recommendations on designing and choosing efficient forms of support structures for development workings. Efficient forms of these structures are given.

  1. Helicity amplitudes of di-photons production at the LHC with scalar unparticles intermediate states

    Energy Technology Data Exchange (ETDEWEB)

    Aliane, I.; Mebarki, N.; Haouchine, M. [Laboratoire de Physique Mathematique et Subatomique, Mentouri University, Constantine (Algeria)


    The helecity amplitudes of the subprocess gg{yields}{gamma}{gamma} via scalar unparticles intermediate states are calculated. The differential cross section is compared to that of the standard model. Phenomenological implications are also discussed.

  2. Why Men Choose Nursing. (United States)

    Perkins, Julia L.; And Others


    Male nursing students surveyed (n=146, 69 percent) responded that (1) career attributes (job security, opportunity, flexibility) were primary reasons for choosing nursing; (2) they had moderate to high support from significant others; and (3) they were more likely to be older and single. (SK)

  3. Choosing for learning objects

    NARCIS (Netherlands)

    Schoonenboom, Judith; Emans, Bruno; Meijer, Joost


    Choosing for learning objects discusses eight educational ambitions and the possible roles of learning objects in realising these ambitions. The eight educational ambitions are: (1) Creating independent learning pathways, for example for lifelong learners; (2) Making education more flexible; (3) Res

  4. The Customer Cannot Choose

    NARCIS (Netherlands)

    A.C.D. Donkers (Bas)


    textabstractPeople can choose and they make many choices each and every day. However, most people are unaware of how strong their environment influences the choices they make. In his inaugural address, Bas Donkers highlights the impact of what people see (and what they don’t see), what people experi

  5. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    Lihua Shi; Yusuf A Hannun; Jianru Zuo; Jacek Bielawski; Jinye Mu; Haili Dong; Chong Teng; Jian Zhang; Xiaohui Yang; Nario Tomishige; Kentaro Hanada


    Sphingolipids have been suggested to act as second messengers for an array of cellular signaling activities in plant cells, including stress responses and programmed cell death (PCD). However, the mechanisms underpinning these processes are not well understood. Here, we report that an Arabidopsis mutant, fumonisin Bl resistant11-1 (fbr11-1), which fails to generate reactive oxygen intermediates (ROIs), is incapable of initiating PCD when the mutant is challenged by fumonisin B1 (FB1), a specific inhibitor of ceramide synthase. Molecular analysis indicated that FBR11 encodes a long-chain basel (LCB1) subunit of serine palmitoyltransferase (SPT), which catalyzes the first rate-limiting step of de novo sphingolipid synthesis. Mass spectrometric analysis of the sphingolipid concentrations revealed that whereas the fbrll-1 mutation did not affect basal levels of sphingoid bases, the mutant showed attenuated formation of sphingoid bases in response to FB1 By a direct feeding experiment, we show that the free sphingoid bases dihydrosphingosine, phytosphingosine and sphingosine efficiently induce ROI generation followed by cell death. Conversely, ROI generation and cell death induced by dihydrosphingosine were specifically blocked by its phosphorylated form dihydrosphingosine-1 -phosphate in a dose-dependent manner, suggesting that the maintenance of homeostasis between a free sphingoid base and its phosphorylated derivative is critical to determining the cell fate. Because alterations of the sphingolipid level occur prior to the ROI production, we propose that the free sphingoid bases are involved in the control of PCD in Arabidopsis, presumably through the regulation of the ROI level upon receiving different developmental or environmental cues.

  6. Choosing for learning objects


    Schoonenboom, Judith; Emans, Bruno; Meijer, Joost


    Choosing for learning objects discusses eight educational ambitions and the possible roles of learning objects in realising these ambitions. The eight educational ambitions are: (1) Creating independent learning pathways, for example for lifelong learners; (2) Making education more flexible; (3) Responding to differences between students; (4) The joint development of learning materials together with other institutions or external parties; (5) Attuning to professional practice; (6) Attuning to...

  7. Nitrogen requirements at bulb initiation for production of intermediate-day onions (United States)

    The effect of nitrogen application on growth, nitrogen (N) uptake, yield, and quality of intermediate-day onion (Allium cepa L. ‘Guimar’) was evaluated in the field in southern Portugal. Plants were fertilized with 30 kg/ha N at transplanting, 10 kg/ha N at 29 days after transplanting (DAT) during ...

  8. Writing Process Products in Intermediate-Grade Children with and without Language-Based Learning Disabilities (United States)

    Koutsoftas, Anthony D.


    Purpose: Difficulties with written expression are an important consideration in the assessment and treatment of school-age children. This study evaluated how intermediate-grade children with and without written language difficulties fared on a writing task housed within the Hayes and Berninger (2014) writing process framework. Method: Sixty-four…

  9. Superasymmetric fission at intermediate energy and production of neutron-rich nuclei with A

    NARCIS (Netherlands)

    Huhta, M; Dendooven, P; Honkanen, A; Jokinen, A; Lhersonneau, G; Oinonen, M; Penttila, H; Perajarvi, K; Rubchenya, VA; Aysto, J


    The yields of neutron-rich Ni, Cu, Zn, Ga and Ge-isotopes were measured in 25 MeV proton induced fission of U-238 using the ion guide-based isotope separator technique. The results indicate enhancement for superasymmetric mass division at intermediate excitation energy of the fissioning nucleus and

  10. Single Intermediate Vector Boson Production in $e^+ e^-$ collisions at $\\sqrt{s}$ = 183 and 189 GeV

    CERN Document Server

    Abreu, P.; Adye, T.; Adzic, P.; Ajinenko, I.; Albrecht, Z.; Alderweireld, T.; Alekseev, G.D.; Alemany, R.; Allmendinger, T.; Allport, P.P.; Almehed, S.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Anassontzis, E.G.; Andersson, P.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.D.; Arnoud, Y.; Asman, B.; Augustin, J.E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barao, F.; Barbiellini, G.; Barbier, R.; Bardin, Dmitri Yu.; Barker, G.J.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.H.; Begalli, M.; Behrmann, A.; Bellunato, T.; Belokopytov, Yu.; Benekos, N.C.; Benvenuti, A.C.; Berat, C.; Berggren, M.; Berntzon, L.; Bertrand, D.; Besancon, M.; Besson, N.; Bilenky, Mikhail S.; Bloch, D.; Blom, H.M.; Bol, L.; Bonesini, M.; Boonekamp, M.; Booth, P.S.L.; Borisov, G.; Bosio, C.; Botner, O.; Boudinov, E.; Bouquet, B.; Bowcock, T.J.V.; Boyko, I.; Bozovic, I.; Bozzo, M.; Bracko, M.; Branchini, P.; Brenner, R.A.; Bruckman, P.; Brunet, J.M.; Bugge, L.; Buschmann, P.; Caccia, M.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Carroll, L.; Caso, C.; Castillo Gimenez, M.V.; Cattai, A.; Cavallo, F.R.; Chapkin, M.; Charpentier, P.; Checchia, P.; Chelkov, G.A.; Chierici, R.; Chliapnikov, P.; Chochula, P.; Chorowicz, V.; Chudoba, J.; Cieslik, K.; Collins, P.; Contri, R.; Cortina, E.; Cosme, G.; Cossutti, F.; Costa, M.; Crawley, H.B.; Crennell, D.; Croix, J.; Crosetti, G.; Cuevas Maestro, J.; Czellar, S.; D'Hondt, J.; Dalmau, J.; Davenport, M.; Da Silva, W.; Della Ricca, G.; Delpierre, P.; Demaria, N.; De Angelis, A.; De Boer, W.; De Clercq, C.; De Lotto, B.; De Min, A.; De Paula, L.; Dijkstra, H.; Di Ciaccio, L.; Doroba, K.; Dracos, M.; Drees, J.; Dris, M.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Engel, J.P.; Espirito Santo, M.C.; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferrer-Ribas, E.; Ferro, F.; Firestone, A.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fontanelli, F.; Franek, B.; Frodesen, A.G.; Fruhwirth, R.; Fulda-Quenzer, F.; Fuster, J.; Galloni, A.; Gamba, D.; Gamblin, S.; Gandelman, M.; Garcia, C.; Gaspar, C.; Gaspar, M.; Gasparini, U.; Gavillet, P.; Gazis, Evangelos; Gele, D.; Geralis, T.; Ghodbane, N.; Gil Botella, Ines; Glege, F.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Gonzalez Caballero, I.; Gopal, G.; Gorn, L.; Gouz, Yu.; Gracco, V.; Grahl, J.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hahn, F.; Hahn, S.; Haider, S.; Hallgren, A.; Hamacher, K.; Hansen, J.; Harris, F.J.; Haug, S.; Hauler, F.; Hedberg, V.; Heising, S.; Hernandez, J.J.; Herquet, P.; Herr, H.; Hertz, O.; Higon, E.; Holmgren, S.O.; Holt, P.J.; Hoorelbeke, S.; Houlden, M.; Hrubec, J.; Hughes, G.J.; Hultqvist, K.; Jackson, John Neil; Jacobsson, R.; Jalocha, P.; Jarlskog, C.; Jarlskog, G.; Jarry, P.; Jean-Marie, B.; Jeans, D.; Johansson, Erik Karl; Jonsson, P.; Joram, C.; Juillot, P.; Jungermann, L.; Kapusta, Frederic; Karafasoulis, K.; Katsanevas, S.; Katsoufis, E.C.; Keranen, R.; Kernel, G.; Kersevan, B.P.; Khokhlov, Yu.A.; Khomenko, B.A.; Khovanski, N.N.; Kiiskinen, A.; King, B.; Kinvig, A.; Kjaer, N.J.; Klapp, O.; Kluit, P.; Kokkinias, P.; Kostioukhine, V.; Kourkoumelis, C.; Kouznetsov, O.; Krammer, M.; Kriznic, E.; Krumstein, Z.; Kubinec, P.; Kucharczyk, M.; Kurowska, J.; Lamsa, J.W.; Laugier, J.P.; Leder, G.; Ledroit, Fabienne; Leinonen, L.; Leisos, A.; Leitner, R.; Lenzen, G.; Lepeltier, V.; Lesiak, T.; Lethuillier, M.; Libby, J.; Liebig, W.; Liko, D.; Lipniacka, A.; Lippi, I.; Loken, J.G.; Lopes, J.H.; Lopez, J.M.; Lopez-Fernandez, R.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Mahon, J.R.; Maio, A.; Malek, A.; Maltezos, S.; Malychev, V.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Marti i Garcia, S.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Matthiae, G.; Mazzucato, F.; Mazzucato, M.; McCubbin, M.; McKay, R.; McNulty, R.; McPherson, G.; Merle, E.; Meroni, C.; Meyer, W.T.; Miagkov, A.; Migliore, E.; Mirabito, L.; Mitaroff, W.A.; Mjoernmark, U.; Moa, T.; Moch, M.; Monig, Klaus; Monge, M.R.; Montenegro, J.; Moraes, D.; Morettini, P.; Morton, G.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.M.; Murray, W.J.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.L.; Nawrocki, K.; Negri, P.; Nemecek, S.; Neufeld, N.; Nicolaidou, R.; Niezurawski, P.; Nikolenko, M.; Nomokonov, V.; Nygren, A.; Obraztsov, V.; Olshevski, A.G.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Pain, R.; Paiva, R.; Palacios, J.; Palka, H.; Papadopoulou, T.D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Pavel, T.; Pegoraro, M.; Peralta, L.; Perepelitsa, V.; Pernicka, M.; Perrotta, A.; Petridou, C.; Petrolini, A.; Phillips, H.T.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M.E.; Polok, G.; Poropat, P.; Pozdniakov, V.; Privitera, P.; Pukhaeva, N.; Pullia, A.; Radojicic, D.; Ragazzi, S.; Rahmani, H.; Ratoff, P.N.; Read, Alexander L.; Rebecchi, P.; Redaelli, Nicola Giuseppe; Regler, M.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.B.; Resvanis, L.K.; Richard, F.; Ridky, J.; Rinaudo, G.; Ripp-Baudot, Isabelle; Romero, A.; Ronchese, P.; Rosenberg, E.I.; Rosinsky, P.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ruiz, A.; Saarikko, H.; Sacquin, Y.; Sadovsky, A.; Sajot, G.; Salmi, L.; Salt, J.; Sampsonidis, D.; Sannino, M.; Savoy-Navarro, A.; Schwanda, C.; Schwemling, P.; Schwering, B.; Schwickerath, U.; Scuri, Fabrizio; Seager, P.; Sedykh, Y.; Segar, A.M.; Sekulin, R.; Sette, G.; Shellard, R.C.; Siebel, M.; Simard, L.; Simonetto, F.; Sisakian, A.N.; Smadja, G.; Smirnov, N.; Smirnova, O.; Smith, G.R.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Spiriti, E.; Stanescu, C.; Stanitzki, M.; Stevenson, K.; Stocchi, A.; Strauss, J.; Strub, R.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Tabarelli, T.; Taffard, A.; Tegenfeldt, F.; Terranova, F.; Timmermans, Jan; Tinti, N.; Tkatchev, L.G.; Tobin, M.; Todorova, S.; Tome, B.; Tonazzo, A.; Tortora, L.; Tortosa, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.L.; Tyapkin, I.A.; Tyapkin, P.; Tzamarias, S.; Ullaland, O.; Uvarov, V.; Valenti, G.; Vallazza, E.; Van Dam, Piet; Van den Boeck, W.; Van Eldik, J.; Van Lysebetten, A.; Van Remortel, N.; Van Vulpen, I.; Vegni, G.; Ventura, L.; Venus, W.; Verbeure, F.; Verdier, P.; Verlato, M.; Vertogradov, L.S.; Verzi, V.; Vilanova, D.; Vitale, L.; Vlasov, E.; Vodopianov, A.S.; Voulgaris, G.; Vrba, V.; Wahlen, H.; Washbrook, A.J.; Weiser, C.; Wicke, D.; Wickens, J.H.; Wilkinson, G.R.; Winter, M.; Witek, M.; Wolf, G.; Yi, J.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zevgolatakos, E.; Zimine, N.I.; Zintchenko, A.; Zoller, P.; Zumerle, G.; Zupan, M.; Krammer, Manfred


    The cross-sections for the production of single charged and neutral intermediate vector bosons were measured using integrated luminosities of 52~pb$^{-1}$ and 154~pb$^{-1}$ collected by the DELPHI experiment at centre-of-mass energies of 182.6~GeV and 188.6~GeV, respectively. The cross-sections for the reactions were determined in limited kinematic regions. The results found are in agreement with the Standard Model predictions for these channels.

  11. Direct production of OH radicals upon CH overtone activation of (CH{sub 3}){sub 2}COO Criegee intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Fang; Beames, Joseph M.; Lester, Marsha I., E-mail: [Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323 (United States)


    Ozonolysis of alkenes, a principle non-photolytic source of atmospheric OH radicals, proceeds through unimolecular decay of energized carbonyl oxide intermediates, known as Criegee intermediates. In this work, cold dimethyl-substituted Criegee intermediates are vibrationally activated in the CH stretch overtone region to drive the 1,4 hydrogen transfer reaction that leads to OH radical products. IR excitation of (CH{sub 3}){sub 2}COO reveals the vibrational states with sufficient oscillator strength, coupling to the reaction coordinate, and energy to surmount the effective barrier (≤ 16.0 kcal mol{sup −1}) to reaction. Insight on the dissociation dynamics is gleaned from homogeneous broadening of the spectral features, indicative of rapid intramolecular vibrational energy redistribution and/or reaction, as well as the quantum state distribution of the OH X{sup 2}Π (v = 0) products. The experimental results are compared with complementary electronic structure calculations, which provide the IR absorption spectrum and geometric changes along the intrinsic reaction coordinate. Additional theoretical analysis reveals the vibrational modes and couplings that permit (CH{sub 3}){sub 2}COO to access to the transition state region for reaction. The experimental and theoretical results are compared with an analogous recent study of the IR activation of syn-CH{sub 3}CHOO and its unimolecular decay to OH products [F. Liu, J. M. Beames, A. S. Petit, A. B. McCoy, and M. I. Lester, Science 345, 1596 (2014)].

  12. Production of dileptons with intermediate masses in an expanding quark-gluon matter

    Institute of Scientific and Technical Information of China (English)


    A study of dilepton spectra, in intermediate mass region (IMR), from main background sources, quark phase, and secondary processes in hadronic phase on the basis of a relativistic hydrodynamic model has been carried out. The comparison between these results indicates that in this mass region the contribution from the background sources dominates, and due to the effect of the phase boundary on the evolution of the system the contribution from the quark phase becomes more important than that from secondary processes.

  13. The folly of using RCCs and RVUs for intermediate product costing. (United States)

    Young, David W


    Two measures for computing the cost of intermediate projects--a ratio of cost to charges and relative value units--are highly flawed and can have serious financial implications for the hospitals that use them. Full-cost accounting, using the principles of activity-based costing, enables hospitals to measure their costs more accurately, both for competitive bidding purposes and to manage them more effectively.

  14. Photocatalytic degradation of methamphetamine by UV/TiO2 - kinetics, intermediates, and products. (United States)

    Kuo, Chin-Sheng; Lin, Cheng-Fang; Hong, Pui-Kwan Andy


    Methamphetamine (MAT) is a prescription drug and often a substance of abuse. It is found in WWTP influents and effluents as well as surface waters in many regions, elevating concerns about their potential impact. MAT is not effectively removed by conventional processes of domestic wastewater treatment plants (WWTPs). To contemplate advanced treatment, this study evaluates the feasibility of eliminating MAT by UV-illuminated TiO2, a potential retrofit to existing UV disinfection units. The degradation kinetics and mechanism of MAT by TiO2 under low-wattage UV illumination (9 W with maximum output at 365 nm) were investigated. Experimental parameters were varied including the TiO2 loading, MAT concentration, and pH. During treatment, MAT and its intermediates were tracked by HPLC-MS/MS, along with TOC and IC measurements to determine the mineralization extent. In contact with 0.1 g/L of TiO2 under illumination at pH 7, an entire spike amount of 100 μg/L of MAT was removed from deionized water after 3 min and 76 μg/L of MAT was removed from the secondary wastewater effluent after 30 min. The degradation of MAT followed an apparent first-order kinetics. Near complete mineralization of MAT from 10 mg/L was achieved in 180 min with 0.1 g/L of TiO2 at pH 5, by which the organic nitrogen was converted to NH4(+) and NO3(-). Based on identified intermediates, two degradation pathways were deduced that involved cleavage of the side chain as well as hydroxylation of the MAT compound. The photocatalytic UV/TiO2 process shows promise in arresting the release of MAT and its intermediate derivatives into the water environment.

  15. "TIVAL" — A development in spectrum tailoring for intermediate-energy neutron beam production (United States)

    Constantine, G.


    Beams of intermediate-energy neutrons produced by filtering offer significant advantages over thermal neutrons for boron neutron capture therapy. Preconditioning the spectrum within the reactor prior to filtering can increase the intensity and lower the mean neutron energy, to give reduced proton recoil damage in normal tissue. Aluminium with a small proportion of D 2O has been proposed as a spectrum shifter to achieve this. We describe here calculations that demonstrate considerable further softening of the spectrum by TIVAL, a mixture of aluminium together with small quantities of titanium and vanadium.

  16. Mixing Envelope D Sludge with LAW Intermediate Products with and without Glass Formers

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, E.K.


    The Department of Energy (DOE) Office of River Protection is in the process of designing a waste treatment system to process the Hanford Reservation High Level Waste (HLW). Envelope D sludge slurries will be blended with the concentrated Cs/Ts eluates, and the Sr/TRU intermediates separated from Envelope A, B, and C feeds. This study produced two washed simulated sludges (representing tanks 241-AZ-101 and 241-AZ-102 sludge), a Sr/TRU washed precipitate produced from tank 241-AN-107 simulant, and a concentrated blended eluate simulant based upon eluates from processing 241-AZ-102 supernate.

  17. Choosing health, constrained choices. (United States)

    Chee Khoon Chan


    In parallel with the neo-liberal retrenchment of the welfarist state, an increasing emphasis on the responsibility of individuals in managing their own affairs and their well-being has been evident. In the health arena for instance, this was a major theme permeating the UK government's White Paper Choosing Health: Making Healthy Choices Easier (2004), which appealed to an ethos of autonomy and self-actualization through activity and consumption which merited esteem. As a counterpoint to this growing trend of informed responsibilization, constrained choices (constrained agency) provides a useful framework for a judicious balance and sense of proportion between an individual behavioural focus and a focus on societal, systemic, and structural determinants of health and well-being. Constrained choices is also a conceptual bridge between responsibilization and population health which could be further developed within an integrative biosocial perspective one might refer to as the social ecology of health and disease.

  18. Mobile communication and intermediality

    DEFF Research Database (Denmark)

    Helles, Rasmus


    The article argues the importance of intermediality as a concept for research in mobile communication and media. The constant availability of several, partially overlapping channels for communication (texting, calls, email, Facebook, etc.) requires that we adopt an integrated view of the various...... communicative affordances of mobile devices in order to understand how people choose between them for different purposes. It is argued that mobile communication makes intermediality especially central, as the choice of medium is detached from the location of stationary media and begins to follow the user across...

  19. Intermediate-sensor assisted push-pull strategy and its application in heterologous deoxyviolacein production in Escherichia coli. (United States)

    Fang, Mingyue; Wang, Tianmin; Zhang, Chong; Bai, Jili; Zheng, Xiang; Zhao, Xuejin; Lou, Chunbo; Xing, Xin-Hui


    Because high-throughput screening tools are typically unavailable when using the pathway-engineering approach, we developed a new strategy, named intermediate sensor-assisted push-pull strategy, which enables sequential pathway optimization by incorporating a biosensor targeting a key pathway intermediate. As proof of concept, we constructed an L-Trp biosensor and used it to optimize the deoxyviolacein biosynthetic pathway, which we divided into two modules with L-Trp being the product of the upstream and the substrate of the downstream module for deoxyviolacein synthesis. Using the biosensor and fluorescence-activated cell sorting, the activities of the two modules were sequentially and independently optimized in Escherichia coli to achieve the desired phenotypes. By this means, we increased the deoxyviolacein titer 4.4-fold (1.92 g/L), which represents the greatest deoxyviolacein production reported. This work suggests that a biosynthetic pathway can be enhanced to produce a value-added secondary metabolite(s) without available end-product screening method by using a central metabolic junction molecule biosensor(s).

  20. Investigating by EPR the reaction processes of intermediate products from the thermodestruction of binary mixtures of coals

    Energy Technology Data Exchange (ETDEWEB)

    Ikonomopulo, V.P.


    Binary mixtures of long-flame, gas-bituminous, coking, lean-caking, and lean coals are used to study the processes for the interaction of intermediate products of the thermodestruction of coals. The value and sign of the paramagnetic effect which occurs during simultaneous heating of coals in a binary mixture are determined by the relative position of each coal on the metamorphic scale. The possible role of plastification and reaction of the two coals in the formation of an ordered paramagnetic structure are demonstrated. 4 references.

  1. Intermediate Mass Dilepton Production in an Expanding Baryon-rich Quark-Gluon Matter

    Institute of Scientific and Technical Information of China (English)

    HE Ze-Jun; JIANG Wei-Zhou; ZHOU Wen-Jie


    The intermediate mass dileptons from the quark phase, secondary hadronic processes and background sources have been studied based on a relativistic hydrodynamic model. Due to the effect of the phase boundary on the evolution of the system the contribution from the quark phase is much more important than that from secondary processes and is even comparable with that from background sources. This leads to a spectrum without the obvious humps of the hadronic phase contribution and the yield increasing with the incident energy of colliding nuclei. It is shown that the enhancement of dileptons is a signature for the formation of the quark-gluon plasma.PACS: 25. 75. Dw, 12. 38. Mh, 24. 10. Nz

  2. Me Nuh Choose None

    Directory of Open Access Journals (Sweden)

    Christina Cooke


    Full Text Available Drawing on textual modes of fictional representation first valorised then disseminated by British imperialists, this story appropriates then abrogates Eurocentric ideals of normative creative expression. By appropriating the rhythm of lyrical poetry into the descriptions of this fictionalized Jamaica as well as the structure of modernist prose into Akúa’s psychical shift from colonial subject to postcolonial agent, “Me Nuh Choose None” inverts these narrative conventions historically used to systematize and exclude in order to puncture the imperious myth that complex writing in English primarily concerns itself with gratifying the colonial centre. Moreover, by treating the textual approximations of the Jamaican storyteller Miss Lou’s oral folktales with equal depth and sophistication as the instances of alliteration and onomatopoeia, this story abrogates the autocratic standard of “proper” spelling and pronunciation so as to textually privilege Jamaican folklore using the literariness usually reserved for Western texts. The effect is a form of fiction that acknowledges the dense matrix of cultural and colonial systems English writing exists within, while simultaneously gesturing between and beyond these systems to the linguistic interstices of postcolonial liminality.

  3. How couples choose vasectomy. (United States)

    Schehl, M


    A study conducted by AVSC International between 1992 and 1995 found that couples around the world go through a highly similar decision-making process when they choose vasectomy as their family planning methods. Study findings are based upon in-depth, qualitative interviews with couples using vasectomy in Bangladesh, Mexico, Kenya, and Rwanda, where the prevalence of vasectomy is relatively low, and Sri Lanka and the US, where it is relatively high. 218 separate interviews were conducted with male and female partners. Concerns about the woman's health were cited by respondents in each country as reasons to cease childbearing and to opt for vasectomy as the means to achieving that end. Also, almost all respondents mentioned varying degrees of financial hardship as contributing to their decision to end childbearing. These findings highlight the concept of partnership in relationships and family planning decision-making, and demonstrate the importance of going beyond traditional stereotypes about gender roles in decision-making. Social influences and the potential risks of using other forms of contraception also contributed to the choice of using vasectomy. The decision-making process and lessons learned are discussed.

  4. A highly productive, whole-cell DERA chemoenzymatic process for production of key lactonized side-chain intermediates in statin synthesis.

    Directory of Open Access Journals (Sweden)

    Matej Ošlaj

    Full Text Available Employing DERA (2-deoxyribose-5-phosphate aldolase, we developed the first whole-cell biotransformation process for production of chiral lactol intermediates useful for synthesis of optically pure super-statins such as rosuvastatin and pitavastatin. Herein, we report the development of a fed-batch, high-density fermentation with Escherichia coli BL21 (DE3 overexpressing the native E. coli deoC gene. High activity of this biomass allows direct utilization of the fermentation broth as a whole-cell DERA biocatalyst. We further show a highly productive bioconversion processes with this biocatalyst for conversion of 2-substituted acetaldehydes to the corresponding lactols. The process is evaluated in detail for conversion of acetyloxy-acetaldehyde with the first insight into the dynamics of reaction intermediates, side products and enzyme activity, allowing optimization of the feeding strategy of the aldehyde substrates for improved productivities, yields and purities. The resulting process for production of ((2S,4R-4,6-dihydroxytetrahydro-2H-pyran-2-ylmethyl acetate (acetyloxymethylene-lactol has a volumetric productivity exceeding 40 g L(-1 h(-1 (up to 50 g L(-1 h(-1 with >80% yield and >80% chromatographic purity with titers reaching 100 g L(-1. Stereochemical selectivity of DERA allows excellent enantiomeric purities (ee >99.9%, which were demonstrated on downstream advanced intermediates. The presented process is highly cost effective and environmentally friendly. To our knowledge, this is the first asymmetric aldol condensation process achieved with whole-cell DERA catalysis and it simplifies and extends previously developed DERA-catalyzed approaches based on the isolated enzyme. Finally, applicability of the presented process is demonstrated by efficient preparation of a key lactol precursor, which fits directly into the lactone pathway to optically pure super-statins.

  5. NEWS: Why choose science? (United States)


    National concerns over the uptake of science subjects and an analysis of how school science departments together with careers programmes influence students' subject choices feature in a recent report from the UK's National Institute for Careers Education and Counselling. It points out that decisions on science subjects are taken very early in pupils' education, often well before the implications of those choices can be clearly understood. If pupils are to be encouraged to keep science options open, then both science teachers and careers advisers have important roles to play. Physics is in fact singled out in the report's recommendations as in need of special attention, due to its perceived difficulty both within the double-award science course and also at A-level. The lack of qualified teachers in physics is noted as a problem for schools and the many initiatives to address these issues should be encouraged according to the report, but within an overall high-profile and well funded national strategy for developing science education in schools. The report also notes that science teachers do not feel able to keep up with career information, whilst few careers advisers have a science background and have little opportunity to build up their knowledge of science syllabuses or of science and engineering careers. More contact between both types of specialist is naturally advocated. Copies of the full report, Choosing Science at 16 by Mary Munro and David Elsom, are available from NICEC, Sheraton House, Castle Park, Cambridge CB3 0AX on receipt of an A4 stamped (70p) addressed envelope. A NICEC briefing summary is also available from the same address (20p stamp required).

  6. The usefulness of intermediate products of plum processing for alcoholic fermentation and chemical composition of the obtained distillates. (United States)

    Balcerek, Maria; Pielech-Przybylska, Katarzyna; Patelski, Piotr; Sapińska, Ewelina; Księżopolska, Mirosława


    In this study, an evaluation of intermediate products of plum processing as potential raw materials for distillates production was performed. Effects of composition of mashes on ethanol yield, chemical composition and taste, and flavor of the obtained spirits were determined. The obtained results showed that spontaneous fermentations of the tested products of plum processing with native microflora of raisins resulted in lower ethanol yields, compared to the ones fermented with wine yeast Saccharomyces bayanus. The supplementation of mashes with 120 g/L of sucrose caused an increase in ethanol contents from 6.2 ± 0.2 ÷ 6.5 ± 0.2% v/v in reference mashes (without sucrose addition, fermented with S. bayanus) to ca. 10.3 ± 0.3% v/v, where its highest yields amounted to 94.7 ± 2.9 ÷ 95.6 ± 2.9% of theoretical capacity, without negative changes in raw material originality of distillates. The concentrations of volatile compounds in the obtained distillates exceeding 2000 mg/L alcohol 100% v/v and low content of methanol and hydrocyanic acid, as well as their good taste and aroma make the examined products of plum processing be very attractive raw materials for the plum distillates production.

  7. Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus. (United States)

    Li, Xingxing; Yu, Tengfei; He, Qing; McDowall, Kenneth J; Jiang, Bingya; Jiang, Zhibo; Wu, Linzhuan; Li, Guangwei; Li, Qinglian; Wang, Songmei; Shi, Yuanyuan; Wang, Lifei; Hong, Bin


    The control of secondary production in streptomycetes involves the funneling of environmental and physiological signals to the cluster-situated (transcriptional) regulators (CSRs) of the biosynthetic genes. For some systems, the binding of biosynthetic products to the CSR has been shown to provide negative feedback. Here we show for the production of lidamycin (C-1027), a clinically relevant antitumor agent, by Streptomyces globisporus that negative feedback can extend to a point higher in the regulatory cascade. We show that the DNA-binding activity of the S. globisporus orthologue of AtrA, which was initially described as a transcriptional activator of actinorhodin biosynthesis in S. coelicolor, is inhibited by the binding of heptaene, a biosynthetic intermediate of lidamycin. Additional experiments described here show that S. globisporus AtrA binds in vivo as well as in vitro to the promoter region of the gene encoding SgcR1, one of the CSRs of lidamycin production. The feedback to the pleiotropic regulator AtrA is likely to provide a mechanism for coordinating the production of lidamycin with that of other secondary metabolites. The activity of AtrA is also regulated by actinorhodin. As AtrA is evolutionarily conserved, negative feedback of the type described here may be widespread within the streptomycetes.

  8. A life-cycle inventory for the production of petrochemical intermediates in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Franke, M.; Berna, J.L.; Cavalli, L.; Renta, C.; Stalmans, M.; Thomas, H.


    The resource requirements and environmental emissions involved in the production of n-paraffins, n-olefins, benzene, ethylene and ethylene oxide from petrochemical feedstocks are presented. (orig./SR) [Deutsch] Der Rohstoffbedarf und die Umweltemissionen bei der Herstellung von n-Olefin, n-Paraffin, Benzen, Ethylen und Ethylenoxid auf der Basis petrochemischer Rohstoffe werden dargestellt. (orig./SR)

  9. Theoretical and experimental studies of the neutron rich fission product yields at intermediate energies

    Directory of Open Access Journals (Sweden)

    Äystö J.


    Full Text Available A new method to measure the fission product independent yields employing the ion guide technique and a Penning trap as a precision mass filter, which allows an unambiguous identification of the nuclides is presented. The method was used to determine the independent yields in the proton-induced fission of 232Th and 238U at 25 MeV. The data were analyzed with the consistent model for description of the fission product formation cross section at the projectile energies up to 100 MeV. Pre-compound nucleon emission is described with the two-component exciton model using Monte Carlo method. Decay of excited compound nuclei is treated within time-dependent statistical model with inclusion of the nuclear friction effect. The charge distribution of the primary fragment isobaric chain was considered as a result of frozen quantal fluctuations of the isovector nuclear density. The theoretical predictions of the independent fission product cross sections are used for normalization of the measured fission product isotopic distributions.

  10. Role of glycolytic intermediate in regulation: Improving lycopene production in Escherichia coli by engineering metabolic control

    Energy Technology Data Exchange (ETDEWEB)

    Farmer, W.R.; Liao, J.C.


    Metabolic engineering in the postgenomic era is expected to benefit from a full understanding of the biosynthetic capability of microorganisms as a result of the progress being made in bioinformatics and functional genomics. The immediate advantage of such information is to allow the rational design of novel pathways and the elimination of native reactions that are detrimental or unnecessary for the desired purpose. However, with the ability to manipulate metabolic pathways becoming more effective, metabolic engineering will need to face a new challenge: the reengineering of the regulatory hierarchy that controls gene expression in those pathways. In addition to constructing the genetic composition of a metabolic pathway, they propose that it will become just as important to consider the dynamics of pathways gene expression. It has been widely observed that high-level induction of a recombinant protein or pathway leads to growth retardation and reduced metabolic activity. These phenotypic characteristics result from the fact that the constant demands of production placed upon the cell interfere with its changing requirements for growth. They believe that this common situation in metabolic engineering can be alleviated by designing a dynamic controller that is able to sense the metabolic state of the cell and regulate the expression of the recombinant pathway accordingly. This approach, which is termed metabolic control engineering, involves redesigning the native regulatory circuits and applying them to the recombinant pathway. The general goal of such an effort will be to control the flux to the recombinant pathway adaptively according to the cell's metabolic state. The dynamically controlled recombinant pathway can potentially lead to enhanced production, minimized growth retardation, and reduced toxic by-product formation. The regulation of gene expression in response to the physiological state is also essential to the success of gene therapy. Here they

  11. How Customers Choose Hotels

    Directory of Open Access Journals (Sweden)

    Hera Oktadiana


    Full Text Available In the advancement of hospitality industry, thus it is important for hotel sales and marketing to understand the customer behavior in order to create effective marketing. Factors that influence customer behavior as individuality consist of personal and interpersonal factors. Personal factors include the needs, wants, motivation, perception, learning, personality, lifestyle, and self-concept. Meanwhile, interpersonal factors come from culture and sub-culture, group references, customers through stages before deciding to purchase. Begin with the awareness about the needs, customers then find information about the product or service that could be used to solve the problems. After having the information, customers select the best product and service before deciding to purchase. After purchasing, the last stage is evaluation of product and service, whether it is satisfying or not.

  12. Isolation and quantitative HPLC-PDA analysis of lupeol in phytopharmaceutical intermediate products from Vernonanthura ferruginea (Less. H. Rob.

    Directory of Open Access Journals (Sweden)

    Ezequiane Machado Silva Oliveira


    Full Text Available Prior to obtain a standardized dried extract from V. ferruginea, lupeol was first time isolated from leaves and used as chemical maker. An analytical method using HPLC-PDA for lupeol determination in V. ferruginea intermediate products was developed using a C8 reverse-phase column, acetonitrile-acetic acid (99.99:0.01, v/v as mobile phase at 0.8 mL min-1, oven temperature at 23-25 ºC, sample injection volume at 30 µL and detection at 210 nm. The method presented linearity from 10 to 160 µg mL-1, accuracy, precision, robustness and suitable sensitivity proving to be a useful tool to the obtainment process of lupeol standardized dried extracts of V. ferruginea.

  13. Metabolic products of microorganisms. 249. Tetracenomycins B3 and D3, key intermediates of the elloramycin and tetracenomycin C biosynthesis. (United States)

    Rohr, J; Eick, S; Zeeck, A; Reuschenbach, P; Zähner, H; Fiedler, H P


    Tetracenomycins B3 and D3, besides tetracenomycin D (D1), were produced by a blocked mutant of the elloramycin producer Streptomyces olivaceus TU 2353. The compounds were isolated as red powders, and their structures were elucidated by comparing their physicochemical data with those of the known tetracenomycins A2, B1, B2, D and E. Tetracenomycin B3 (2), the main compound, and tetracenomycin D (3) were antibiotically inactive against Gram-positive and Gram-negative bacteria, whereas tetracenomycin D3 (1) showed a moderate activity against Bacillus subtilis and Arthrobacter aurescens. Tetracenomycin B3 (2) is the key intermediate where the biosynthesis of the elloramycins branches off from the line leading to tetracenomycin C (5) as the final product of the tetracenomycin biosynthesis branch.

  14. Vector mesons in dense matter and dilepton production in heavy ion collisions at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Santini, Elvira


    The vector meson spectral functions are calculated to the first order in the nuclear matter density assuming the dominant contribution comes from the couplings of the vector mesons to nucleons and nucleon resonances. An attempt is made to reproduce the HADES dilepton production data with the in-medium spectral functions of the vector mesons using the Relativistic Quantum Molecular Dynamics (RQMD) transport model developed earlier for modelling heavy-ion collisions. The results are sensitive to the in-medium broadening of nucleon resonances. A generally good agreement with the HADES data is achieved for selfconsistent treatment of the nucleon resonance broadening and the vector meson spectral functions. (orig.)


    Directory of Open Access Journals (Sweden)



    Full Text Available A method for producing Gallic acid by microbiological hydrolysis of the tannins of tripods powder is described in the present work. Hydrolysis of gallotanins of the substrate to Gallic acid by aspergilus niger MTCC 282 was studied. A simple extraction procedure is used. Fungal mycelia pre-induced with 5 g/l gallotanin was used as inocolums. Optimal values for various physico-chemical parameters including substrate concentration, inocolum levels, pH, temperature, fermentation, inocolum age, agitatioin, gallotanin concentration nultritional source and metal ion were determined. The yield of Gallic acide with respect to gallotannins present in the substrate is estimated. Yield of Gallic acid are about 82% with respect to gallotannin concentration, which suggests that this method ix exploitable industrially for manufacturing Trimethoprim drug.Currnet total requirment of Gallic acid is around 8,000 tones per year all over the world. Conventionally Gallic acid is being produced by acid hydrolysis of tannin rich source. But this technology has serval disadvantages regarding cost, yield and purity of the product. This technology alos causes a lot of environmental pollution being a chemical process. The present technique of conversion of teri tannins to Gallic acid using fungal mycelia viz, aspergillus niger MTCC 282, being purely a bioconversion is free from pollution with more purity of product.

  16. Bio-oil production of softwood and hardwood forest industry residues through fast and intermediate pyrolysis and its chromatographic characterization. (United States)

    Torri, Isadora Dalla Vecchia; Paasikallio, Ville; Faccini, Candice Schmitt; Huff, Rafael; Caramão, Elina Bastos; Sacon, Vera; Oasmaa, Anja; Zini, Claudia Alcaraz


    Bio-oils were produced through intermediate (IP) and fast pyrolysis (FP), using Eucalyptus sp. (hardwood) and Picea abies (softwood), wood wastes produced in large scale in Pulp and Paper industries. Characterization of these bio-oils was made using GC/qMS and GC×GC/TOFMS. The use of GC×GC provided a broader characterization of bio-oils and it allowed tracing potential markers of hardwood bio-oil, such as dimethoxy-phenols, which might co-elute in 1D-GC. Catalytic FP increased the percentage of aromatic hydrocarbons in P. abies bio-oil, indicating its potential for fuel production. However, the presence of polyaromatic hydrocarbons (PAH) draws attention to the need of a proper management of pyrolysis process in order to avoid the production of toxic compounds and also to the importance of GC×GC/TOFMS use to avoid co-elutions and consequent inaccuracies related to identification and quantification associated with GC/qMS. Ketones and phenols were the major bio-oil compounds and they might be applied to polymer production.

  17. Biological Production of a Hydrocarbon Fuel Intermediate Polyhydroxybutyrate (PHB) from a Process Relevant Lignocellulosic Derived Sugar (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, W.; Mittal, A.; Mohagheghi, A.; Johnson, D. K.


    PHAs are synthesized by many microorganisms to serve as intracellular carbon storage molecules. In some bacterial strains, PHB can account for up to 80% of cell mass. In addition to its application in the packaging sector, PHB also has great potential as an intermediate in the production of hydrocarbon fuels. PHB can be thermally depolymerized and decarboxylated to propene which can be upgraded to hydrocarbon fuels via commercial oligomerization technologies. Cupriavidus necator is the microorganism that has been most extensively studied and used for PHB production on an industrial scale; However the substrates used for producing PHB are mainly fructose, glucose, sucrose, fatty acids, glycerol, etc., which are expensive. In this study, we demonstrate production of PHB from a process relevant lignocellulosic derived sugar stream, i.e., saccharified slurry from pretreated corn stover. The strain was first investigated in shake flasks for its ability to utilize glucose, xylose and acetate. In addition, the strain was also grown on pretreated lignocellulose hydrolyzate slurry and evaluated in terms of cell growth, sugar utilization, PHB accumulation, etc. The mechanism of inhibition in the toxic hydrolysate generated by the pretreatment and saccharification process of biomass, was also studied.

  18. 97e Intermediate Temperature Catalytic Reforming of Bio-Oil for Distributed Hydrogen Production

    Energy Technology Data Exchange (ETDEWEB)

    Marda, J. R.; Dean, A. M.; Czernik, S.; Evans, R. J.; French, R.; Ratcliff, M.


    With the world's energy demands rapidly increasing, it is necessary to look to sources other than fossil fuels, preferably those that minimize greenhouse emissions. One such renewable source of energy is biomass, which has the added advantage of being a near-term source of hydrogen. While there are several potential routes to produce hydrogen from biomass thermally, given the near-term technical barriers to hydrogen storage and delivery, distributed technologies such that hydrogen is produced at or near the point of use are attractive. One such route is to first produce bio-oil via fast pyrolysis of biomass close to its source to create a higher energy-density product, then ship this bio-oil to its point of use where it can be reformed to hydrogen and carbon dioxide. This route is especially well suited for smaller-scale reforming plants located at hydrogen distribution sites such as filling stations. There is also the potential for automated operation of the conversion system. A system has been developed for volatilizing bio-oil with manageable carbon deposits using ultrasonic atomization and by modifying bio-oil properties, such as viscosity, by blending or reacting bio-oil with methanol. Non-catalytic partial oxidation of bio-oil is then used to achieve significant conversion to CO with minimal aromatic hydrocarbon formation by keeping the temperature at 650 C or less and oxygen levels low. The non-catalytic reactions occur primarily in the gas phase. However, some nonvolatile components of bio-oil present as aerosols may react heterogeneously. The product gas is passed over a packed bed of precious metal catalyst where further reforming as well as water gas shift reactions are accomplished completing the conversion to hydrogen. The approach described above requires significantly lower catalyst loadings than conventional catalytic steam reforming due to the significant conversion in the non-catalytic step. The goal is to reform and selectively oxidize the

  19. Deglacial variability in Okhotsk Sea Intermediate Water ventilation and biogeochemistry: Implications for North Pacific nutrient supply and productivity (United States)

    Lembke-Jene, Lester; Tiedemann, Ralf; Nürnberg, Dirk; Kokfelt, Ulla; Kozdon, Reinhard; Max, Lars; Röhl, Ursula; Gorbarenko, Sergey A.


    The modern North Pacific plays a critical role in marine biogeochemical cycles, as an oceanic sink of CO2 and by bearing some of the most productive and least oxygenated waters of the World Ocean. The capacity to sequester CO2 is limited by efficient nutrient supply to the mixed layer, particularly from deeper water masses in the Pacific's subarctic and marginal seas. The region is in addition only weakly ventilated by North Pacific Intermediate Water (NPIW), which receives its characteristics from Okhotsk Sea Intermediate Water (OSIW). Here, we present reconstructions of intermediate water ventilation and productivity variations in the Okhotsk Sea that cover the last glacial termination between eight and 18 ka, based on a set of high-resolution sediment cores from sites directly downstream of OSIW formation. In a multi-proxy approach, we use total organic carbon (TOC), chlorin, biogenic opal, and CaCO3 concentrations as indicators for biological productivity. C/N ratios and XRF scanning-derived elemental ratios (Si/K and Fe/K), as well as chlorophycean algae counts document changes in Amur freshwater and sediment discharge that condition the OSIW. Stable carbon isotopes of epi- and shallow endobenthic foraminifera, in combination with 14C analyses of benthic and planktic foraminifera imply decreases in OSIW oxygenation during deglacial warm phases from c. 14.7 to 13 ka (Bølling-Allerød) and c. 11.4 to 9 ka (Preboreal). No concomitant decreases in Okhotsk Sea benthic-planktic ventilation ages are observed, in contrast to nearby, but southerly locations on the Japan continental margin. We attribute Okhotsk Sea mid-depth oxygenation decreases in times of enhanced organic matter supply to maxima in remineralization within OSIW, in line with multi-proxy evidence for maxima in primary productivity and supply of organic matter. Sedimentary C/N and Fe/K ratios indicate more effective entrainment of nutrients into OSIW and thus an increased nutrient load of OSIW during

  20. Decentralized scheduling algorithm to improve the rate of production without increasing the stocks of intermediates; Zaiko wo fuyasu kotonaku seisan sokudo wo kojo saseru jiritsu bunsangata sukejuringu arugorizumu

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Kazuhiro; Shiigi, Daisuke; Tsuge, Yoshifumi; Matsuyama, Hisayoshi [Kyushu University, Fukuoka (Japan). Department of Chemical Engineering


    In a factory with a multi-stage production system, push-type scheduling methods can hardly improve the production rate without increasing the stocks of intermediates. For products whose specifications are known before their orders, a pull-type scheduling method named Kanban system has been developed, and has succeeded to improve the production rate without increasing the stocks of intermediates. The Kanban system, however, is not applicable to custom-made products whose specifications are not known before their orders. In this paper, a 'Virtual Kanban (VK) system' is presented as a pull-type scheduling method which is applicable to custom-made products, and its usefulness is demonstrated by simulation of an application specific integrated circuit manufacturing facility. (author)

  1. Experimental Study of W Z Intermediate Bosons Associated Production with the CDF Experiment at the Tevatron Collider

    Energy Technology Data Exchange (ETDEWEB)

    Pozzobon, Nicola; /Pisa U.


    Studying WZ associated production at the Fermilab Tevatron Collider is of great importance for two main reasons. On the one hand, this process would be sensitive to anomalies in the triple gauge couplings such that any deviation from the value predicted by the Standard Model would be indicative of new physics. In addition, by choosing to focus on the final state where the Z boson decays to b{bar b} pairs, the event topology would be the same as expected for associated production of a W and a Standard Model light Higgs boson (m{sub H} {approx}< 135 GeV) which decays into b{bar b} pairs most of times. The process WH {yields} W b{bar b} has an expected {sigma} {center_dot} B about five times lower than WZ {yields} Wb{bar b} for m{sub H} {approx_equal} 120 GeV. Therefore, observing this process would be a benchmark for an even more difficult search aiming at discovering the light Higgs in the WH {yields} Wb{bar b} process. After so many years of Tevatron operation only a weak WZ signal was recently observed in the full leptonic decay channel, which suffers from much less competition from background. Searching for the Z in the b{bar b} decay channel in this process is clearly a very challenging endeavour. In the work described in this thesis, WZ production is searched for in a final state where the W decays leptonically to an electron-neutrino pair or a muon-neutrino pair, with associated production of a jet pair consistent with Z decays. A set of candidate events is obtained by applying appropriate cuts to the parameters of events collected by wide acceptance leptonic triggers. To improve the signal fraction of the selected events, an algorithm was used to tag b-flavored jets by means of their content of long lived b-hadrons and corrections were developed to the jet algorithm to improve the b-jet energy resolution for a better reconstruction of the Z mass. In order to sense the presence of a signal one needs to estimate the amount of background. The relative content of

  2. Reactive Nitrogen Intermediates Production by Macrophages of Mycobacterium bovis-Infected Goats and Supplemented with Dyhidroxyvitamin D3 in vivo

    Directory of Open Access Journals (Sweden)

    Aurora Martinez-Romero


    Full Text Available Problem statement: Tuberculosis (TB remains one of the world's major health problems. To evaluate in vivo indices of cellular sensitization, antigen-induced Reactive Nitrogen Intermediates (RNI responses by blood mononuclear cells from Mycobacterium bovis BCG-infected goats supplemented with 1, 25 dyhidroxyvitamin D3 [1, 25-(OH2D3]. Approach: An experimental, longitudinal and comparative study was planned. Twelve animals of goat cattle 20-to 24-month-old sannen selected themselves. Five samplings were made, previous to the inoculation (zero d, 3, 7, 14 and 21 d after applying the treatments. The mononuclear cells by the Ficoll-hypaque method were obtained. The RNI, nitrites and nitrates (NO2- and NO3-­ were quantified by Enzyme-Linked Immunosorbent Assay (ELISA. Results: The treatment with the 1, 25(OH2D3 stimulated the NO3- synthesis indicating, that by itself it is a good modulador of the micobacterial replication and in the treatment with M. bovis-BCG vaccine increased as a result to the treatment with 1,25(OH2D3. The exhibition to M. bovis-BCG vaccine with the treatment with 1, 25(OH2D3 was able to increase answer NO3-­ in exposed animals. Conclusion: The 1, 25(OH2D3 stimulated in vivo the production of RNI in goats exposed to M. bovis BCG vaccine.

  3. Monash Chemical Yields Project (Monχey) Element production in low- and intermediate-mass stars (United States)

    Doherty, Carolyn; Lattanzio, John; Angelou, George; Campbell, Simon W.; Church, Ross; Constantino, Thomas; Cristallo, Sergio; Gil-Pons, Pilar; Karakas, Amanda; Lugaro, Maria; Stancliffe, Richard

    The Monχey project will provide a large and homogeneous set of stellar yields for the low- and intermediate- mass stars and has applications particularly to galactic chemical evolution modelling. We describe our detailed grid of stellar evolutionary models and corresponding nucleosynthetic yields for stars of initial mass 0.8 M⊙ up to the limit for core collapse supernova (CC-SN) ~ 10 M⊙. Our study covers a broad range of metallicities, ranging from the first, primordial stars (Z = 0) to those of super-solar metallicity (Z = 0.04). The models are evolved from the zero-age main-sequence until the end of the asymptotic giant branch (AGB) and the nucleosynthesis calculations include all elements from H to Bi. A major innovation of our work is the first complete grid of heavy element nucleosynthetic predictions for primordial AGB stars as well as the inclusion of extra-mixing processes (in this case thermohaline) during the red giant branch. We provide a broad overview of our results with implications for galactic chemical evolution as well as highlight interesting results such as heavy element production in dredge-out events of super-AGB stars. We briefly introduce our forthcoming web-based database which provides the evolutionary tracks, structural properties, internal/surface nucleosynthetic compositions and stellar yields. Our web interface includes user- driven plotting capabilities with output available in a range of formats. Our nucleosynthetic results will be available for further use in post processing calculations for dust production yields.

  4. MID Max: LC–MS/MS Method for Measuring the Precursor and Product Mass Isotopomer Distributions of Metabolic Intermediates and Cofactors for Metabolic Flux Analysis Applications

    DEFF Research Database (Denmark)

    McCloskey, Douglas; Young, Jamey D.; Xu, Sibei


    The analytical challenges to acquire accurate isotopic data of intracellular metabolic intermediates for stationary, nonstationary, and dynamic metabolic flux analysis (MFA) are numerous. This work presents MID Max, a novel LC–MS/MS workflow, acquisition, and isotopomer deconvolution method for MFA...... product spectra) with accuracy and precision. The compounds measured included metabolic intermediates in central carbohydrate metabolism and cofactors of peripheral metabolism (e.g., ATP). Using only a subset of the acquired MIDs, the method was found to improve the precision of flux estimations...... and number of resolved exchange fluxes for wild-type E. coli compared to traditional methods and previously published data sets....

  5. Children and (Five Choose Two). (United States)

    Zvonkin, Alexander K.


    Recounts a teacher's experiences with a small group of elementary school students as they explore different forms of the combinatorics problem of choosing two out of five objects. Describes how students examine the connections between the problems and a proof of the relationship. (MDH)

  6. Why Do Women Choose Nursing? (United States)

    Boughn, Susan; Lentini, Alison


    In interviews with 16 female nursing students, caring was a motivator, but power and empowerment for self and others were the most fully developed reasons for choosing nursing. They showed scant interest in practical motivations such as salary, security, and working conditions. (SK)

  7. Basis for calculating technological parameters of preparation of minced salted fish products of intermediate moisture with specified physical and chemical characteristics

    Directory of Open Access Journals (Sweden)

    Stepanenko E. I.


    Full Text Available The dependence of water activity on basic physical and chemical characteristics of salted fish products with intermediate moisture has been defined. During the research the product quality has been assessed by the organoleptic method; determination of the water mass fraction has been carried out by the drying method; the salt mass fraction – by the argentometric method; water activity has been measured by a cooled mirror dew-point sensor. Based on experimental data the dependence of Aw on concentration of sodium chloride in the salt semi-finished products of pollock (Theragra chalcogramma, Atlantic herring (Clupea harengus, Baltic cod (Gadus morhua callarias, blue whiting (Micromesistius, pink salmon (Oncorhynchus gorbuscha, horse mackerel (Trachurus trachurus has been established. The empirical formula showing the correlation of the parameter (Aw with mass fraction of sodium chloride and water has been derived; on its basis it is possible to calculate the parameters of semi-finished product in order to obtain a final minced salt product of intermediate moisture with desired microbial stability upon storage. The relations between the salt mass fraction and water mass fraction excluding bacterial spoilage and mold growth has been determined, they make up S ≥ 0,135 ∙ W and S ≥ 0,34 ∙ W respectively, where S – the mass fraction of salt, %, W – the mass fraction of water, %. An example of calculating the required dosage of sodium chloride in the semi-finished minced salmon has been described to produce the finished product with the exactly given values of humidity and water activity. During the process of minced salted fish products' dehydration the basic physical and chemical parameters – the mass fraction of salt and water affecting the water activity (Aw – have been changing. Determination of these parameters' relationship provides the ability to predict the qualitative changes of salted fish products of intermediate moisture

  8. Intermediate composition magma production in an intracontinental setting: Unusual andesites and dacites of the mid-Miocene Santa Rosa-Calico volcanic field, Northern Nevada (United States)

    Brueseke, Matthew E.; Hart, William K.


    The mid-Miocene Santa Rosa-Calico volcanic field (SC) of northern Nevada provides an outstanding example of the role open-system magmatic processes play in producing calc-alkaline and tholeiitic andesite-dacite magmas in an intracontinental setting. SC volcanism commenced at ˜ 16.7 Ma and is associated with the initial manifestations of the Yellowstone hotspot, the Columbia River-Steens flood basalt event(s), and the formation of the Northern Nevada rift. Locally a diverse package of magmatic products ranging from tholeiitic basalt to high-Si rhyolite was produced during an ˜ 2 myr duration. Within this package are the products of at least four distinct intermediate composition magmatic systems that may represent as much as 40% of the SC volcanic pile. These help differentiate the SC from contemporaneous Oregon Plateau volcanic fields (e.g. McDermitt, Lake Owyhee, Northwest Nevada) that are dominated by bimodal basalt-rhyolite assemblages. All SC intermediate units are characterized by textural and mineralogic complexities including xenoliths and xenocrysts of local crust and crystal clots of plagioclase ± clinopyroxene ± orthopyroxene ± oxide. SC intermediate units are dominantly tholeiitic, but include lava flows with transitional to calc-alkaline affinities. Relative to locally erupted Steens Basalt, SC intermediate lava flows have similar elemental enrichments and depletions, but dissimilar Sr and Nd isotopic compositions. These isotopic differences, coupled with the abundant disequilibrium features and variable incompatible element ratios, indicate that open system magmatic processes played a major role in the genesis of the intermediate units. SC silicic magmas were produced primarily via upper crustal melting of chemically and isotopically heterogeneous Cretaceous granitoid. Interaction between fractionating mafic Steens flood basalt magmas and the more evolved crustal melts ± assimilation of local upper crust provides a general template for the

  9. Effect of cellulose crystallinity on the formation of a liquid intermediate and on product distribution during pyrolysis

    NARCIS (Netherlands)

    Wang, Zhouhong; McDonald, Armando G.; Westerhof, Roel J.M.; Kersten, Sascha R.A.; Cuba-Torres, Christian M.; Ha, Su; Pecha, Brennan; Garcia-Perez, Manuel


    The effect of cellulose crystallinity on the formation of a liquid intermediate and on its thermal degradation was studied thermogravimetrically and by Py-GC/MS using a control cellulose (Avicel, crystallinity at 60.5%) and ball-milled Avicel (low cellulose crystallinity at 6.5%). The crystallinity

  10. Comparative techno-economic analysis and process design for indirect liquefaction pathways to distillate-range fuels via biomass-derived oxygenated intermediates upgrading: Liquid Transportation Fuel Production via Biomass-derived Oxygenated Intermediates Upgrading

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Eric C. D. [National Renewable Energy Laboratory, Golden CO USA; Snowden-Swan, Lesley J. [Pacific Northwest National Laboratory, Richland WA USA; Talmadge, Michael [National Renewable Energy Laboratory, Golden CO USA; Dutta, Abhijit [National Renewable Energy Laboratory, Golden CO USA; Jones, Susanne [Pacific Northwest National Laboratory, Richland WA USA; Ramasamy, Karthikeyan K. [Pacific Northwest National Laboratory, Richland WA USA; Gray, Michel [Pacific Northwest National Laboratory, Richland WA USA; Dagle, Robert [Pacific Northwest National Laboratory, Richland WA USA; Padmaperuma, Asanga [Pacific Northwest National Laboratory, Richland WA USA; Gerber, Mark [Pacific Northwest National Laboratory, Richland WA USA; Sahir, Asad H. [National Renewable Energy Laboratory, Golden CO USA; Tao, Ling [National Renewable Energy Laboratory, Golden CO USA; Zhang, Yanan [National Renewable Energy Laboratory, Golden CO USA


    This paper presents a comparative techno-economic analysis (TEA) of five conversion pathways from biomass to gasoline-, jet-, and diesel-range hydrocarbons via indirect liquefaction with a specific focus on pathways utilizing oxygenated intermediates. The four emerging pathways of interest are compared with one conventional pathway (Fischer-Tropsch) for the production of the hydrocarbon blendstocks. The processing steps of the four emerging pathways include biomass-to-syngas via indirect gasification, syngas clean-up, conversion of syngas to alcohols/oxygenates followed by conversion of alcohols/oxygenates to hydrocarbon blendstocks via dehydration, oligomerization, and hydrogenation. Conversion of biomass-derived syngas to oxygenated intermediates occurs via three different pathways, producing: (i) mixed alcohols over a MoS2 catalyst, (ii) mixed oxygenates (a mixture of C2+ oxygenated compounds, predominantly ethanol, acetic acid, acetaldehyde, ethyl acetate) using an Rh-based catalyst, and (iii) ethanol from syngas fermentation. This is followed by the conversion of oxygenates/alcohols to fuel-range olefins in two approaches: (i) mixed alcohols/ethanol to 1-butanol rich mixture via Guerbet reaction, followed by alcohol dehydration, oligomerization, and hydrogenation, and (ii) mixed oxygenates/ethanol to isobutene rich mixture and followed by oligomerization and hydrogenation. The design features a processing capacity of 2000 tonnes/day (2205 short tons) of dry biomass. The minimum fuel selling prices (MFSPs) for the four developing pathways range from $3.40 to $5.04 per gasoline-gallon equivalent (GGE), in 2011 US dollars. Sensitivity studies show that MFSPs can be improved with co-product credits and are comparable to the commercial Fischer-Tropsch benchmark ($3.58/GGE). Overall, this comparative TEA study documents potential economics for the developmental biofuel pathways via mixed oxygenates.

  11. Comparative techno-economic analysis and process design for indirect liquefaction pathways to distillate-range fuels via biomass-derived oxygenated intermediates upgrading: Liquid Transportation Fuel Production via Biomass-derived Oxygenated Intermediates Upgrading

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Eric C. D. [National Renewable Energy Laboratory, Golden CO USA; Snowden-Swan, Lesley J. [Pacific Northwest National Laboratory, Richland WA USA; Talmadge, Michael [National Renewable Energy Laboratory, Golden CO USA; Dutta, Abhijit [National Renewable Energy Laboratory, Golden CO USA; Jones, Susanne [Pacific Northwest National Laboratory, Richland WA USA; Ramasamy, Karthikeyan K. [Pacific Northwest National Laboratory, Richland WA USA; Gray, Michel [Pacific Northwest National Laboratory, Richland WA USA; Dagle, Robert [Pacific Northwest National Laboratory, Richland WA USA; Padmaperuma, Asanga [Pacific Northwest National Laboratory, Richland WA USA; Gerber, Mark [Pacific Northwest National Laboratory, Richland WA USA; Sahir, Asad H. [National Renewable Energy Laboratory, Golden CO USA; Tao, Ling [National Renewable Energy Laboratory, Golden CO USA; Zhang, Yanan [National Renewable Energy Laboratory, Golden CO USA


    This paper presents a comparative techno-economic analysis (TEA) of five conversion pathways from biomass to gasoline-, jet-, and diesel-range hydrocarbons via indirect liquefaction with specific focus on pathways utilizing oxygenated intermediates. The four emerging pathways of interest are compared with one conventional pathway (Fischer-Tropsch) for the production of the hydrocarbon blendstocks. The processing steps of the four emerging pathways include: biomass to syngas via indirect gasification, gas cleanup, conversion of syngas to alcohols/oxygenates followed by conversion of alcohols/oxygenates to hydrocarbon blendstocks via dehydration, oligomerization, and hydrogenation. Conversion of biomass-derived syngas to oxygenated intermediates occurs via three different pathways, producing: 1) mixed alcohols over a MoS2 catalyst, 2) mixed oxygenates (a mixture of C2+ oxygenated compounds, predominantly ethanol, acetic acid, acetaldehyde, ethyl acetate) using an Rh-based catalyst, and 3) ethanol from syngas fermentation. This is followed by the conversion of oxygenates/alcohols to fuel-range olefins in two approaches: 1) mixed alcohols/ethanol to 1-butanol rich mixture via Guerbet reaction, followed by alcohol dehydration, oligomerization, and hydrogenation, and 2) mixed oxygenates/ethanol to isobutene rich mixture and followed by oligomerization and hydrogenation. The design features a processing capacity of 2,000 tonnes/day (2,205 short tons) of dry biomass. The minimum fuel selling prices (MFSPs) for the four developing pathways range from $3.40 to $5.04 per gasoline-gallon equivalent (GGE), in 2011 US dollars. Sensitivity studies show that MFSPs can be improved with co-product credits and are comparable to the commercial Fischer-Tropsch benchmark ($3.58/GGE). Overall, this comparative TEA study documents potential economics for the developmental biofuel pathways via mixed oxygenates.

  12. Production of planar copper-based anode supported intermediate temperature solid oxide fuel cells cosintered at 950 °C (United States)

    De Marco, Vincenzo; Grazioli, Alberto; Sglavo, Vincenzo M.


    Copper-based anode supported planar Intermediate Temperature Solid Oxide Fuel Cells are produced and characterized in the present work. The most important advancement is related to the use of copper within the anodic layer, this giving promising results for feeding Intermediate Temperature Solid Oxide Fuel Cells with carbon and sulphur containing fuels. Both anode and Li2O containing-Gadolinia Doped Ceria based electrolyte are produced by water based tape casting process. The supporting anode is coupled to the electrolyte by thermopressing, the cathode being obtained by screen printing. A 3 h isotherm at 950 °C allows to obtain the cosintering of the three layers. The electrochemical test performed on such cells reveals a 0.8 V open circuit voltage and a power density higher than 26 mW cm-2 at 650 °C.

  13. How to choose the route. (United States)

    Grecu, Irina


    Choosing the route for nutrition support delivery is one of the main steps in the algorithm of providing successful nutrition to the critically ill, but it is certainly not an easy process. The rationale should be guided not only by principles like physiology and benefit versus harm, but also by individual patient factors like feasibility, contraindications, predicted versus actual tolerance, and (most important) the timing for starting food delivery. Although oral nutrition is the more physiological route for feeding, it is seldom possible or sufficient in critically ill patients. Enteral nutrition, in the form of tube feeding, remains the best option in the absence of absolute contraindications, but many other factors should be taken into account. These include the importance of starting early and trying to achieve target nutrients delivery early, especially in previously undernourished or in most severely ill patients, as well as the gastrointestinal intolerance present in the majority of critically ill patients. Parenteral nutrition is an alternative route for nutrition delivery when the enteral one is impossible or insufficient. The most common complication when choosing this route is overfeeding, which has been associated with increased complications rate. On the other hand, the most common complication of enteral nutrition is underfeeding, which has also been associated with worse outcome and even increased mortality. Combining enteral with supplemental parenteral nutrition is therefore a rational approach for providing early and adequate nutritional support in the most severely ill patients.

  14. MID Max: LC-MS/MS Method for Measuring the Precursor and Product Mass Isotopomer Distributions of Metabolic Intermediates and Cofactors for Metabolic Flux Analysis Applications. (United States)

    McCloskey, Douglas; Young, Jamey D; Xu, Sibei; Palsson, Bernhard O; Feist, Adam M


    The analytical challenges to acquire accurate isotopic data of intracellular metabolic intermediates for stationary, nonstationary, and dynamic metabolic flux analysis (MFA) are numerous. This work presents MID Max, a novel LC-MS/MS workflow, acquisition, and isotopomer deconvolution method for MFA that takes advantage of additional scan types that maximizes the number of mass isotopomer distributions (MIDs) that can be acquired in a given experiment. The analytical method was found to measure the MIDs of 97 metabolites, corresponding to 74 unique metabolite-fragment pairs (32 precursor spectra and 42 product spectra) with accuracy and precision. The compounds measured included metabolic intermediates in central carbohydrate metabolism and cofactors of peripheral metabolism (e.g., ATP). Using only a subset of the acquired MIDs, the method was found to improve the precision of flux estimations and number of resolved exchange fluxes for wild-type E. coli compared to traditional methods and previously published data sets.

  15. Relatively Selective Production of the Simplest Criegee Intermediate in a CH4/O2 Electric Discharge: Kinetic Analysis of a Plausible Mechanism. (United States)

    Nguyen, Thanh Lam; McCarthy, Michael C; Stanton, John F


    High -accuracy coupled cluster methods in combination with microcanonical semiclassical transition state theory are used to investigate a plausible formation mechanism of the simplest Criegee intermediate in a CH4/O2 discharge experiment. Our results suggest that the Criegee intermediate is produced in a three-step process: (i) production of methyl radical by cleavage of a C-H bond of CH4; (ii) association of methyl radical with molecular oxygen to form a vibrationally excited methyl peroxy, which is in a rapid microequilibrium with the reactants; and finally, (iii) H-abstraction of CH3OO by O2, which results in the formation of cool CH2OO, which has insufficient internal energy to rearrange to dioxirane.

  16. 垄断竞争、中间产品与城市规模%Monopolistic Competition, Intermediate Product and City Scale

    Institute of Scientific and Technical Information of China (English)

    陈向阳; 陈日新


    从分工经济与城市规模之间关系的角度,运用Dixit-Stiglitz模型框架下经济活动的规模收益递增原理,在城市内部最终产品生产企业利润最大化的条件下,系统讨论了投入的中间产品种类数与城市人口规模之间的关系、中间产品之间的替代性对城市均衡人口规模的反馈作用,以及城市内部中间产品专业化水平和互补经济程度之间的关系。在此基础上,利用广东省城市增长的部分数据进行了实证分析。认为:经济活动的集聚形成了城市;在城市体积增长和城市系统随产业的专业化与多样化发展而演进的过程中,城市规模经济的实现除了依赖生产要素流动外,最终产品生产企业对中间产品投入的需求也具有不可忽视的作用。%From the perspective of the relationship between division economy and city scale,this paper uses the principle of increasing returns to scale based on the Dixit-Stiglitz model framewrok to discuss the relationship between the kind number of intermediate input used in the production of final goods and the urban population scale, and the feedback role of the substitution elasticity among intermediate products to the urban equilibrium population scale, and the relationship between the professional level of intermediate products and the complementarity among inter- mediate products in the condition of maximizing final goods producers~ profit. Then it uses the data about urban growth of Guangdong to study empirically the above theoretical conclusions. Finally. It concludes as follows:cities are formed in the agglomeration of economic activities;in the process of urban scale growth and urban system evolution with the diversification and spatialization of industries, urban scale economy relies on not only the flow of production factors but also the demand of producers of final goods for intermediate products.

  17. Educational Vouchers: Freedom to Choose?

    Directory of Open Access Journals (Sweden)

    Jordan Reel


    Full Text Available Milton Friedman is famous for his book title: “Free to Choose.” He also favors educational vouchers, which denies the freedom to choose to people who do not wish to subsidize the education of other people’s children. Thus, he is guilty of a logical contradiction. Why is it important to assess whether Friedman’s views on educational vouchers are logically consistent with his widespread reputation as an advocate of free enterprise, and, thus, freedom to chose? It is important to assess all figures in political economy, and indeed all of scholarship, for logical consistency. It is particularly important to do so in the present case, given the prestige in certain quarters accorded to this Nobel prize-winning economist. We argue in this paper that Friedman’s reputation for logical consistency, and adherence to the philosophy of laissez faire capitalism, are both overblown. Our solution to this challenge is to completely privatize education. Friedman does not advocate that vouchers be utilized for food, clothing or shelter; we see no relevant difference in the case of education. What is the justification of the undertaken topic? This topic is important because education of the next generation is crucial for the upkeep and improvement of society. What is the aim of the present study? It is to demonstrate that the solution offered by M. Friedman and R. Friedman (1990 is highly problematic. What is the methodology used in the study? We quote from this author, and criticize his analysis. What are our main results and conclusions/recommendations? We conclude that the last best hope for the educational industry is laissez faire capitalism, not the mixed economy recommended by Friedman.

  18. Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker. (United States)

    Takamatsu, Masayuki; Fukase, Koichi; Kurbangalieva, Almira; Tanaka, Katsunori


    We demonstrated synthetically that the eight-membered heterocycles 2,6,9-triazabicyclo[3.3.1]nonanes and 1,5-diazacyclooctanes are the initial and exclusive products of the reaction, through an imino [4+4] cycloaddition, of biologically relevant amines with acrolein. The stabilities of the aminoacetals within the eight-membered heterocycles determined whether the product was subsequently transformed gradually into the 3-formyl-3,4-dehydropiperidine (FDP), which is widely used as an oxidative stress marker. The reactivity profiles discovered in this study suggested that some of the imino [4+4] cycloaddition products are reactive intermediates of FDP and contribute to the mechanisms underlying the oxidative stress response to acrolein.

  19. A model for particle production in nuclear reactions at intermediate energies: application to C-C collisions at 95 MeV/nucleon

    CERN Document Server

    Dudouet, Jérémie


    A model describing nuclear collisions at intermediate energies is presented and the results are compared with recently measured double differential cross sections in C-C reactions at 95 MeV/nucleon. Results show the key role played by geometrical effects and the memory of the entrance channel, in particular the momentum distributions of the two incoming nuclei. Special attention is paid to the description of processes occurring at mid-rapidity. To this end, a random particle production mechanism by means of a coalescence process in velocity space is considered in the overlap region of the two interacting nuclei.

  20. A thermodynamic approach to choosing pervaporatives membranes

    Directory of Open Access Journals (Sweden)

    Mahacine Amrani


    Full Text Available This work describes separating a mixture of several components obtained as a product of methyl polymethyl metha- crylate (PMMA thermo-degradation. It was aimed at purifying methyl methacrylate monomer (MMA obtained by 95% mass thermal degradation to reach 99.5% maximum pervaporation concentration. This work studied the theory of pervaporation and applying the main thermodynamic criteria for choosing suitable polymer membranes for separating the MMA/PRP/ISB mixture. Such thermodynamic criteria were based on monomer interaction with and solubility on the membrane. The advantage of using this separation technique lies mainly in the fact that this method has low energy consumption compared to other processes, such as distillation or crystallisation.

  1. 4-hydroxyphenylpyruvate dioxygenase catalysis: identification of catalytic residues and production of a hydroxylated intermediate shared with a structurally unrelated enzyme. (United States)

    Raspail, Corinne; Graindorge, Matthieu; Moreau, Yohann; Crouzy, Serge; Lefèbvre, Bertrand; Robin, Adeline Y; Dumas, Renaud; Matringe, Michel


    4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) into homogentisate. HPPD is the molecular target of very effective synthetic herbicides. HPPD inhibitors may also be useful in treating life-threatening tyrosinemia type I and are currently in trials for treatment of Parkinson disease. The reaction mechanism of this key enzyme in both plants and animals has not yet been fully elucidated. In this study, using site-directed mutagenesis supported by quantum mechanical/molecular mechanical theoretical calculations, we investigated the role of catalytic residues potentially interacting with the substrate/intermediates. These results highlight the following: (i) the central role of Gln-272, Gln-286, and Gln-358 in HPP binding and the first nucleophilic attack; (ii) the important movement of the aromatic ring of HPP during the reaction, and (iii) the key role played by Asn-261 and Ser-246 in C1 hydroxylation and the final ortho-rearrangement steps (numbering according to the Arabidopsis HPPD crystal structure 1SQD). Furthermore, this study reveals that the last step of the catalytic reaction, the 1,2 shift of the acetate side chain, which was believed to be unique to the HPPD activity, is also catalyzed by a structurally unrelated enzyme.

  2. Combining UHPLC-High Resolution MS and Feeding of Stable Isotope Labeled Polyketide Intermediates for Linking Precursors to End Products

    DEFF Research Database (Denmark)

    Klitgaard, Andreas; Frandsen, Rasmus John Normand; Holm, Dorte Koefoed


    We present the results from stable isotope labeled precursor feeding studies combined with ultrahigh performance liquid chromatography-high resolution mass spectrometry for the identification of labeled polyketide (PK) end-products. Feeding experiments were performed with 13C8-6-methylsalicylic...... spp., YWA1 was shown to be incorporated into aurofusarin, rubrofusarin, and antibiotic Y. In A. niger, benzoic acid was shown to be incorporated into asperrubrol. Incorporation levels of 0.7–20% into the end-products were detected in wild-type strains. Thus, stable isotope labeling is a promising...

  3. Growth/no growth models for Zygosaccharomyces rouxii associated with acidic, sweet intermediate moisture food products

    DEFF Research Database (Denmark)

    Nielsen, Cecilie Lykke Marvig; Kristiansen, Rikke M.; Nielsen, Dennis Sandris


    is important to ensure microbiological stability and aid product development. Several models have been developed for fat based, sweet IMFs. However, fruit/sugar based IMFs, such as fruit based chocolate fillings and jams, have lower pH and aw than what is accounted for in previously developed models...

  4. Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis. (United States)

    Parman, T; Chen, G; Wells, P G


    Phenytoin and related xenobiotics can be bioactivated by embryonic prostaglandin H synthase (PHS) to a teratogenic free radical intermediate. The mechanism of free radical formation was evaluated using photolytic oxidation with sodium persulfate and by EPR spectrometry. Characterization of the products by mass spectrometry suggested that phenytoin photolyzes to a nitrogen-centered radical that rapidly undergoes ring opening to form a carbon-centered radical. PHS-1 was incubated with teratogen (phenytoin, mephenytoin, trimethadione, phenobarbital, and major metabolites) or its vehicle and the free radical spin trap alpha-phenyl-N-t-butylnitrone, and incubations were analyzed by EPR spectrometry. There was no alpha-phenyl-N-t-butylnitrone radical adduct in control incubations. For phenytoin, a putative unstable nitrogen-centered radical adduct and a stable carbon-centered radical adduct were detected. Free radical spin adducts also were detected for all other teratogens and metabolites except carbamazepine. The PHS inhibitor eicosatetraynoic acid abolished the free radical EPR signal. Incubation of 2'-deoxyguanosine with phenytoin and PHS-1 resulted in a 5-fold increase in its oxidation to 8-hydroxy-2'-deoxyguanosine. This is the first direct chemical evidence for PHS-catalyzed bioactivation of phenytoin and related teratogens to a free radical intermediate that initiates DNA oxidation, which may constitute a common molecular mechanism of teratologic initiation.

  5. Choosing a Breast Prosthesis: A Survivor's Perspective (United States)

    ... Choosing a Breast Prosthesis: A Survivor’s Perspective Choosing a Breast Prosthesis: A Survivor’s Perspective Andrea Zinn June 16, 2015 · Amber ... preferences. Q: Why did you decide to wear a breast form/prosthesis rather than have a reconstruction? ...

  6. Kinetic and product studies of Criegee intermediate reactions with halogenated and non-halogenated carboxylic acids and their implications in the troposphere (United States)

    Chhantyal-Pun, Rabi; Rotavera, Brandon; Eskola, Arkke; Taatjes, Craig; Percival, Carl; Shallcross, Dudley; Orr-Ewing, Andrew


    Criegee intermediates are important species formed during the ozonolysis of alkenes. Direct measurement and modelling studies have shown that reactions of stabilized Criegee intermediates with species like SO2 and NO2 may have a significant effect in tropospheric chemistry.[1, 2] Reaction rates of Criegee intermediates with simple carboxylic acids like HCOOH and CH3COOH have been shown to be near the collision limit and may be a significant sink for these otherwise stable species in the atmosphere.[3, 4] Results obtained from our time-resolved Cavity Ring-Down Spectroscopy (CRDS) apparatus[5] for reactions of the Criegee intermediates, CH2OO and (CH3)2COO with various halogenated (CF3COOH, CF3CF2COOH, CClF2COOH and CHCl2COOH) and non-halogenated (HCOOH and CH3COOH) carboxylic acids will be presented, together with Structure Activity Relationship (SAR) based on these observations. Structure characterization of the products from these reactions using the Multiplexed PhotoIonization Mass Spectrometry (MPIMS) apparatus[1,3] as well as implications for Secondary Organic Aerosol (SOA) formation, assessed using the global atmospheric model STOCHEM, will also be discussed. Bibliography 1. O. Welz, J. D. Savee, D. L. Osborn, S. S. Vasu, C. J. Percival, D. E. Shallcross and C. A. Taatjes, Science, 2012, 335, 204-207. 2. C. J. Percival, O. Welz, A. J. Eskola, J. D. Savee, D. L. Osborn, D. O. Topping, D. Lowe, S. R. Utembe, A. Bacak, G. McFiggans, M. C. Cooke, P. Xiao, A. T. Archibald, M. E. Jenkin, R. G. Derwent, I. Riipinen, D. W. K. Mok, E. P. F. Lee, J. M. Dyke, C. A. Taatjes and D. E. Shallcross, Faraday Discuss., 2013, 165, 45-73. 3. O. Welz, A. J. Eskola, L. Sheps, B. Rotavera, J. D. Savee, A. M. Scheer, D. L. Osborn, D. Lowe, A. M. Booth, P. Xiao, M. A. H. Khan, C. J. Percival, D. E. Shallcross and C. A. Taatjes, Angew. Chem. Int. Ed., 2014, 53, 4547-4550. 4. M. D. Hurley, M. P. S. Andersen, T. J. Wallington, D. A. Ellis, J. W. Martin and S. A. Mabury, J. Phys. Chem. A

  7. Enhanced production of resveratrol derivatives in tobacco plants by improving the metabolic flux of intermediates in the phenylpropanoid pathway. (United States)

    Jeong, Yu Jeong; An, Chul Han; Woo, Su Gyeong; Park, Ji Hye; Lee, Ki-Won; Lee, Sang-Hoon; Rim, Yeonggil; Jeong, Hyung Jae; Ryu, Young Bae; Kim, Cha Young


    The biosynthesis of flavonoids such as anthocyanin and stilbenes has attracted increasing attention because of their potential health benefits. Anthocyanins and stilbenes share common phenylpropanoid precursor pathways. We previously reported that the overexpression of sweetpotato IbMYB1a induced anthocyanin pigmentation in transgenic tobacco (Nicotiana tabacum) plants. In the present study, transgenic tobacco (Nicotiana tabacum SR1) plants (STS-OX and ROST-OX) expressing the RpSTS gene encoding stilbene synthase from rhubarb (Rheum palmatum L. cv. Jangyeop) and the RpSTS and VrROMT genes encoding resveratrol O-methyltransferase from frost grape (Vitis riparia) were generated under the control of 35S promoter. Phenotypic alterations in floral organs, such as a reduction in floral pigments and male sterility, were observed in STS-OX transgenic tobacco plants. However, we failed to obtain STS-OX and ROST-OX plants with high levels of resveratrol compounds. Therefore, to improve the production of resveratrol derivatives in plants, we cross-pollinated flowers of STS-OX or ROST-OX and IbMYB1a-OX transgenic lines (SM and RSM). Phenotypic changes in vegetative and reproductive development of SM and RSM plants were observed. Furthermore, by HPLC and LC-MS analyses, we found enhanced production of resveratrol derivatives such as piceid, piceid methyl ether, resveratrol methyl ether O-hexoside, and 5-methyl resveratrol-3,4'-O-β-D-diglucopyranoside in SM and RSM cross-pollinated lines. Here, total contents of trans- and cis-piceids ranged from approximately 104-240 µg/g fresh weight in SM (F2). Collectively, we suggest that coexpression of RpSTS and IbMYB1a via cross-pollination can induce enhanced production of resveratrol compounds in plants by increasing metabolic flux into stilbenoid biosynthesis.

  8. Velocity map imaging of O-atom products from UV photodissociation of the CH{sub 2}OO Criegee intermediate

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hongwei; Fang, Yi; Beames, Joseph M.; Lester, Marsha I., E-mail: [Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323 (United States)


    UV excitation of jet-cooled CH{sub 2}OO X{sup 1}A′ to the excited B{sup 1}A′ electronic states results in dissociation to two spin-allowed product channels: H{sub 2}CO X{sup 1}A{sub 1} + O {sup 1}D and H{sub 2}CO a{sup 3}A″ + O {sup 3}P. In this study, the higher energy H{sub 2}CO a{sup 3}A″ + O {sup 3}P channel is characterized by velocity map imaging and UV action spectroscopy, in both cases utilizing 2 + 1 resonance enhanced multiphoton ionization detection of O {sup 3}P products, which complements a prior experimental study on the lower energy H{sub 2}CO X{sup 1}A{sub 1} + O {sup 1}D channel [Lehman et al., J. Chem. Phys. 139, 141103 (2013)]. Anisotropic angular distributions indicative of rapid dissociation are obtained at 330 and 350 nm, along with broad and unstructured total kinetic energy distributions that provide insight into the internal excitation of the H{sub 2}CO a{sup 3}A″ co-fragment. A harmonic normal mode analysis points to significant vibrational excitation of the CH{sub 2} wag and C–O stretch modes of the H{sub 2}CO a{sup 3}A″ fragment upon dissociation. At each UV wavelength, the termination of the kinetic energy distribution reveals the energetic threshold for the H{sub 2}CO a{sup 3}A″ + O {sup 3}P product channel of ca. 76 kcal mol{sup −1} (378 nm) and also establishes the dissociation energy from CH{sub 2}OO X{sup 1}A′ to H{sub 2}CO X{sup 1}A{sub 1} + O{sup 1}D products of D{sub 0} ≤ 49.0 ± 0.3 kcal mol{sup −1}, which is in accord with prior theoretical studies. The threshold for the H{sub 2}CO a{sup 3}A″ + O {sup 3}P channel is also evident as a more rapid falloff on the long wavelength side of the O {sup 3}P action spectrum as compared to the previously reported UV absorption spectrum for jet-cooled CH{sub 2}OO [Beames et al., J. Am. Chem. Soc. 134, 20045 (2012)]. Modeling suggests that the O {sup 3}P yield increases uniformly from 378 to 300 nm.

  9. Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Aβ Peptide and O2. (United States)

    Reybier, Karine; Ayala, Sara; Alies, Bruno; Rodrigues, João V; Bustos Rodriguez, Susana; La Penna, Giovanni; Collin, Fabrice; Gomes, Cláudio M; Hureau, Christelle; Faller, Peter


    Oxidative stress is considered as an important factor and an early event in the etiology of Alzheimer's disease (AD). Cu bound to the peptide amyloid-β (Aβ) is found in AD brains, and Cu-Aβ could contribute to this oxidative stress, as it is able to produce in vitro H2O2 and HO˙ in the presence of oxygen and biological reducing agents such as ascorbate. The mechanism of Cu-Aβ-catalyzed H2O2 production is however not known, although it was proposed that H2O2 is directly formed from O2 via a 2-electron process. Here, we implement an electrochemical setup and use the specificity of superoxide dismutase-1 (SOD1) to show, for the first time, that H2O2 production by Cu-Aβ in the presence of ascorbate occurs mainly via a free O2˙(-) intermediate. This finding radically changes the view on the catalytic mechanism of H2O2 production by Cu-Aβ, and opens the possibility that Cu-Aβ-catalyzed O2˙(-) contributes to oxidative stress in AD, and hence may be of interest.

  10. Engineering Isoprenoid Biosynthesis in Artemisia annua L. for the Production of Taxadiene: A Key Intermediate of Taxol

    Directory of Open Access Journals (Sweden)

    Meiya Li


    Full Text Available Taxadiene is the first committed precursor to paclitaxel, marketed as Taxol, arguably the most important anticancer agent against ovarian and breast cancer. In Taxus, taxadiene is directly synthesized from geranylgeranyl diphosphate (GGPP that is the common precursor for diterpenoids and is found in most plants and microbes. In this study, Artemisia annua L., a Chinese medicinal herb that grows fast and is rich in terpenoids, was used as a genetic engineering host to produce taxadiene. The TXS (taxadiene synthase gene, cloned from Taxus and inserted into pCAMBIA1304, was transformed into Artemisia annua L. using the Agrobacterium tumefaciens-mediated method. Thirty independent transgenic plants were obtained, and GC-MS analysis was used to confirm that taxadiene was produced and accumulated up to 129.7 μg/g dry mass. However, the high expression of TXS did not affect plant growth or photosynthesis in transgenic Artemisia annua L. It is notable that artemisinin is produced and stored in leaves and most taxadiene accumulated in the stem of transgenic Artemisia annua L., suggesting a new way to produce two important compounds in one transgenic plant: leaves for artemisinin and stem for taxadiene. Overall, this study demonstrates that genetic engineering of the taxane biosynthetic pathway in Artemisia annua L. for the production of taxadiene is feasible.

  11. Choosing a Geothermal as an HVAC System. (United States)

    Lensenbigler, John D.


    Describes the process of selecting and installing geothermal water source heat pumps for new residence halls at Johnson Bible College in Knoxville, Tennessee, including choosing the type of geothermal design, contractors, and interior equipment, and cost and payback. (EV)

  12. How to choose a health plan (United States)

    ... patientinstructions/000861.htm How to choose a health plan To use the sharing features on this page, ... paperwork for tax purposes. How to Compare Health Plans Employers and government sites, such as the Marketplace , ...

  13. Skilled nursing and rehabilitation facilities - choosing (United States)

    ... page: // Skilled nursing and rehabilitation facilities - choosing To use the sharing ... you may need to go to a skilled nursing or rehabilitation facility . Skilled nursing facilities provide care ...

  14. Experimental study of the mechanism of production of intermediate-mass fragments in relativistic /ital p/+Au and /sup 4/He+Au interactions

    Energy Technology Data Exchange (ETDEWEB)

    Avdeichikov, V. V.; Bogdanov, A. I.; Budilov, V. A.; Ganza, E. A.; Gorshkova, N. L.; Denisenko, K. G.; Zhidkov, N. K.; Lozhkin, O. V.; Murin, Y. A.; Nikitin, V. A.; and others


    Differential cross sections for production of intermediate-mass fragments (/ital Z/=5--12) have been measured in the reactions /ital p/+Au/r arrow//ital Z/+/ital X/ and /sup 4/He+Au/r arrow//ital Z/+/ital X/ at angles 35--135/degree/. The energy range of the proton beam was 2.6--7.5 GeV, and that of the /sup 4/He beam 1.3--13.5 GeV. Total cross sections have been measured for production of fragments with /ital Z/=5--9 and have been approximated by the function sigma(/ital Z/)/similar to//ital Z//sup /minus//tau//. For the reaction /sup 4/He+Au a minimum of the function /tau/(/ital E//sub /sup 4/He/) is observed at /ital E//congruent/6 GeV. The cross sections are analyzed in the framework of a model which assumes the existence of two sources of fragments with different transport velocity. The nonmonotonic behavior of the parameter /tau/ is related to the cross-section component due to decay of the fast source of fragments.

  15. Choosing and using astronomical eyepieces

    CERN Document Server

    Paolini, William


    This valuable reference fills a number of needs in the field of astronomical eyepieces, including that of a buyer's guide, observer's field guide and technical desk reference. It documents the past market for eyepieces and its evolution right up to the present day. In addition to appealing to practical astronomers - and potentially saving them money - it is useful both as a historical reference and as a detailed review of the current market place for this bustling astronomical consumer product. What distinguishes this book from other publications on astronomy is the involvement of observers from all aspects of the astronomical community, and also the major manufacturers of equipment. It not only catalogs the technical aspects of the many modern eyepieces but also documents amateur observer reactions and impressions of their utility over the years, using many different eyepieces. Eyepieces are the most talked-about accessories and collectible items available to the amateur astronomer. No other item of equi...

  16. 中间产品进口对中国高技术产品出口技术含量的影响%Import of Intermediate Products Impact on Exports Technology of China's High-tech Products

    Institute of Scientific and Technical Information of China (English)

    肖浩; 胡小娟; 辛丽萍


    在新贸易理论的指导下,国际贸易模式不断发展与创新,产品内贸易盛行。本文根据2000—2013年高技术产品五大行业面板数据,基于豪斯曼构建的产品出口复杂度指标对中国高技术产品的出口技术含量进行测度,得出这期间其出口技术含量呈现逐年上升的趋势。本文引入虚拟变量,实证分析 FDI、R&D 及中间产品进口五大行业对其出口技术含量的影响。结果表明,总体来说 FDI、R&D 和中间产品进口均有助于提升产品的出口技术含量;但对细分行业来说,中间产品进口与出口技术含量的关系是不确定的,需要区分不同类型的产品,电子及通信设备、电子计算机及办公设备和医疗设备及仪器仪表三类产品的中间产品进口会促进高技术产品出口技术含量的提升,而医药和航空航天器产品的中间产品进口则会阻碍其出口技术含量的提升。%Under the guidance of the new trade theory,the modes of international trade are developing and in-novating,and trades in products are popular.In this paper,according to the five industry panel data from 2000 to 2013,and export complexity index based on Hausmann,it is concluded that the export technical content showed a trend of rising year by year.This paper introduces virtual variables,analyzing FDI,R&D and import of intermediate products,and the results show that the overall FDI,R&D and the import of intermediate products can promote the export of the product technology content,but for niche business,the import and export of intermediate product tech-nology content are not quite related,which need to distinguish among different types of products.Importing in terme-diate products of electronic and communication equipment,computers and office equipment,and medical equipment and instrumentation can promote the export of high-tech products,while importing intermediate products of pharma-ceutical and aerial will

  17. Biodegradation of sulfamethazine by Trametes versicolor: Removal from sewage sludge and identification of intermediate products by UPLC-QqTOF-MS

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Galan, Ma. Jesus, E-mail: [Departament de Quimica Ambiental, IDAEA-CSIC, C/Jordi Girona 18-26, 08034 Barcelona (Spain); Rodriguez-Rodriguez, Carlos E., E-mail: [Unitat asociada de Biocatalisi Aplicada IQAC-CSIC, Escola d' Enginyeria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona (Spain); Centro de Investigacion en Contaminacion Ambiental, Universidad de Costa Rica, 2060 San Jose (Costa Rica); Vicent, Teresa, E-mail: [Departament d' Enginyeria Quimica, Escola d' Enginyeria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona (Spain); Caminal, Gloria, E-mail: [Unitat asociada de Biocatalisi Aplicada IQAC-CSIC, Escola d' Enginyeria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona (Spain); Diaz-Cruz, M. Silvia, E-mail: [Departament de Quimica Ambiental, IDAEA-CSIC, C/Jordi Girona 18-26, 08034 Barcelona (Spain); Barcelo, Damia, E-mail: [Departament de Quimica Ambiental, IDAEA-CSIC, C/Jordi Girona 18-26, 08034 Barcelona (Spain); Catalan Institute for Water Research (ICRA), Parc Cientific i Tecnologic de la Universitat de Girona. C/Emili Grahit, 101 Edifici H2O, E-17003 Girona (Spain); King Saud University, P.O. Box 2455, Riyadh 11451 (Saudi Arabia)


    Degradation of the sulfonamide sulfamethazine (SMZ) by the white-rot fungus Trametes versicolor was assessed. Elimination was achieved to nearly undetectable levels after 20 h in liquid medium when SMZ was added at 9 mg L{sup -1}. Experiments with purified laccase and laccase-mediators resulted in almost complete removal. On the other hand, inhibition of SMZ degradation was observed when piperonilbutoxide, a cytochrome P450-inhibitor, was added to the fungal cultures. UPLC-QqTOF-MS analysis allowed the identification and confirmation of 4 different SMZ degradation intermediates produced by fungal cultures or purified laccase: desulfo-SMZ, N{sup 4}-formyl-SMZ, N{sup 4}-hydroxy-SMZ and desamino-SMZ; nonetheless SMZ mineralization was not demonstrated with the isotopically labeled sulfamethazine-phenyl-{sup 13}C{sub 6} after 7 days. Inoculation of T. versicolor to sterilized sewage sludge in solid-phase systems showed complete elimination of SMZ and also of other sulfonamides (sulfapyridine, sulfathiazole) at real environmental concentrations, making this fungus an interesting candidate for further remediation research. - Highlights: {yields}Degradation of sulfamethazine by Trametes versicolor was evaluated. {yields}The laccase enzymatic system and cytochrome P-450 were involved in the degradation. {yields}Four different degradation products of sulfamethazine were identified and confirmed. {yields}The molecular structures and masses of the metabolites were accurately calculated. {yields}Full elimination of sulfamethazine was observed in regular sewage sludge.

  18. Methane, ammonia, and their irradiation products at the surface of an intermediate-size KBO? A portrait of Plutino (90482) Orcus

    CERN Document Server

    Delsanti, Audrey; Guilbert, Aurélie; Bauer, James; Yang, Bin; Meech, Karen J


    Orcus is an intermediate-size 1000km-scale Kuiper Belt Object in 3:2 mean-motion resonance with Neptune, in an orbit very similar to that of Pluto. We present visible and near-infrared photometry and spectroscopy obtained with the Keck 10m-telescope and the Gemini 8m-telescope . We confirm the unambiguous detection of crystalline water ice as well as absorption in the 2.2\\mu m region. Both in the visible and near-infrared Orcus' spectral properties appear to be homogeneous over time (and probably rotation) at the resolution available. From Hapke radiative transfer models involving intimate mixtures of various ices we find for the first time that ammonium (NH+4) and traces of ethane (C2 H6), which are most probably solar irradiation products of ammonia and methane, and a mixture of methane and ammonia (diluted or not) are the best candidates to improve the description of the data with respect to a simple water ice mixture (Haumea type surface). The possible more subtle structure of the 2.2\\mu m band(s) should ...

  19. Modeling of S-Nitrosothiol-Thiol Reactions of Biological Significance: HNO Production by S-Thiolation Requires a Proton Shuttle and Stabilization of Polar Intermediates. (United States)

    Ivanova, Lena V; Cibich, Daniel; Deye, Gregory; Talipov, Marat R; Timerghazin, Qadir K


    Nitroxyl (HNO), a reduced form of the important gasotransmitter nitric oxide, exhibits its own unique biological activity. A possible biological pathway of HNO formation is the S-thiolation reaction between thiols and S-nitrosothiols (RSNOs). Our density functional theory (DFT) calculations suggested that S-thiolation proceeds through a proton transfer from the thiol to the RSNO nitrogen atom, which increases electrophilicity of the RSNO sulfur, followed by nucleophilic attack by thiol, yielding a charge-separated zwitterionic intermediate structure RSS(+) (R)N(H)O(-) (Zi), which decomposes to yield HNO and disulfide RSSR. In the gas phase, the proton transfer and the S-S bond formation are asynchronous, resulting in a high activation barrier (>40 kcal mol(-1) ), making the reaction infeasible. However, the barrier can decrease below the S-N bond dissociation energy in RSNOs (≈30 kcal mol(-1) ) upon transition into an aqueous environment that stabilizes Zi and provides a proton shuttle to synchronize the proton transfer and the S-S bond formation. These mechanistic features suggest that S-thiolation can easily lend itself to enzymatic catalysis and thus can be a possible route of endogenous HNO production.

  20. Photolytic and photocatalytic transformation of methadone in aqueous solutions under solar irradiation: kinetics, characterization of major intermediate products and toxicity evaluation. (United States)

    Postigo, Cristina; Sirtori, Carla; Oller, Isabel; Malato, Sixto; Maldonado, Manuel Ignacio; López de Alda, Miren; Barceló, Damià


    The present manuscript describes the transformation and mineralization of methadone (MET) in aqueous solutions (demineralized water (DW) and synthetic municipal wastewater effluent (SWeff)) by natural solar irradiation and two solar photocatalytic processes: heterogeneous photocatalysis with titanium dioxide (TiO2) and homogeneous photocatalysis by photo-Fenton. Direct solar irradiation resulted in almost complete transformation of MET in the investigated matrices after 20 h of normalized irradiation time. MET photocatalytic transformation required shorter illumination times in DW compared to SWeff. Only 16 and 36 min of solar illumination were required during photo-Fenton and photocatalysis with TiO2, respectively, to transform MET completely in SWeff. Mineralization of the dissolved organic carbon took place only during photocatalytic treatments. Kinetics parameters were calculated for processes comparison. Additionally, phototransformation intermediates generated during each treatment were investigated and characterized by means of ultra-performance liquid chromatography coupled to quadrupole-time of flight tandem mass spectrometry (UPLC-QqTOF-MS/MS). The main MET phototransformation pathways were observed to be hydroxylation, and fragmentation and cyclization. According to the Vibrio fischeri bioassay, the acute toxicity of the generated phototransformation products was not relevant, since the observed inhibition percentages of bacterial bioluminescence were always below 30% after 30 min of sample contact.

  1. Cloud Computing and the Power to Choose (United States)

    Bristow, Rob; Dodds, Ted; Northam, Richard; Plugge, Leo


    Some of the most significant changes in information technology are those that have given the individual user greater power to choose. The first of these changes was the development of the personal computer. The PC liberated the individual user from the limitations of the mainframe and minicomputers and from the rules and regulations of centralized…

  2. Free to Choose Service-Learning. (United States)

    Garber, Michael P.; Heet, Justina A.


    Service learning holds tremendous potential for expanding and enriching children's education. However, community polarization can result when such programs are implemented in schools that are not freely chosen by families of children attending them. Parents must be allowed to choose schools reflecting their priorities and beliefs. (MLH)

  3. Don't Choose Your Own Successor (United States)

    Levinson, Harry


    Chief executive officers (CEOs) often select successors who fail. CEOs may choose badly because they cannot foresee the future, recognize the qualities that led them to success, or betray company traditions. Most often, however, they unconsciously wish to prove that no one can do the job as well as they have. (Author/JF)

  4. Why do men choose to become pedagogues?

    DEFF Research Database (Denmark)

    Wohlgemuth, Ulla Gerner


    This article reports the results from a study on reasons for choosing social education for a profession when you are a man. The study concluded that multiple job opportunities and caring for others is a strong motive for men along with possible further studies. The study also disclosed that many...

  5. Who Chooses Primary Teaching and Why? (United States)

    Weiss, Sabine; Kiel, Ewald


    This study investigates who chooses primary teaching and how prospective primary school teachers differ from future teachers in other types of schools. Using variance analysis, future student-teachers of different types of schools are compared with regard to their motives for the choice of studies and profession. As a main result, prospective…

  6. Contributions of complete fusion and break-up–fusion to intermediate mass fragment production in the low energy interaction of 12C and 27Al

    CERN Document Server

    Förtsch, S V; Colleoni, P; Gadioli, E; Gadioli Erba, E; Mairani, A; Steyn, G F; Lawrie, J J; Smit, F D; Connell, S H; Fearick, R W; Thovhogi, T


    The measured spectra of a large number of intermediate mass fragments produced at a CM energy of about 110 MeV in the 27Al(12C, x) reaction as well as in its inverse reaction, 12C(27Al, x), are presented. The analysis of these data suggests that, at this energy, the main reaction mechanisms which contribute to the intermediate mass fragment emission are two-nucleus complete fusion and break-up–fusion reactions.

  7. Determination of residual acetone and acetone related impurities in drug product intermediates prepared as Spray Dried Dispersions (SDD) using gas chromatography with headspace autosampling (GCHS). (United States)

    Quirk, Emma; Doggett, Adrian; Bretnall, Alison


    Spray Dried Dispersions (SDD) are uniform mixtures of a specific ratio of amorphous active pharmaceutical ingredient (API) and polymer prepared via a spray drying process. Volatile solvents are employed during spray drying to facilitate the formation of the SDD material. Following manufacture, analytical methodology is required to determine residual levels of the spray drying solvent and its associated impurities. Due to the high level of polymer in the SDD samples, direct liquid injection with Gas Chromatography (GC) is not a viable option for analysis. This work describes the development and validation of an analytical approach to determine residual levels of acetone and acetone related impurities, mesityl oxide (MO) and diacetone alcohol (DAA), in drug product intermediates prepared as SDDs using GC with headspace (HS) autosampling. The method development for these analytes presented a number of analytical challenges which had to be overcome before the levels of the volatiles of interest could be accurately quantified. GCHS could be used after two critical factors were implemented; (1) calculation and application of conversion factors to 'correct' for the reactions occurring between acetone, MO and DAA during generation of the headspace volume for analysis, and the addition of an equivalent amount of polymer into all reference solutions used for quantitation to ensure comparability between the headspace volumes generated for both samples and external standards. This work describes the method development and optimisation of the standard preparation, the headspace autosampler operating parameters and the chromatographic conditions, together with a summary of the validation of the methodology. The approach has been demonstrated to be robust and suitable to accurately determine levels of acetone, MO and DAA in SDD materials over the linear concentration range 0.008-0.4μL/mL, with minimum quantitation limits of 20ppm for acetone and MO, and 80ppm for DAA.


    Directory of Open Access Journals (Sweden)

    ROIBAN Roxana Nadina


    Full Text Available Choosing the most appropriate form of licensing a business is an important decision not easy to be made by an entrepreneur and it should be taken only after he has the required skills and abilities to do so. The business idea should harmonize with the business environment and its future trends, with the existing opportunities and the future products or services that the company will provide and not least the entrepreneur has to make sure that he has sufficient resources to get started. We consider that every business has a number of features that make certain forms of licensing to be more suitable than others. This paper aims to present a multitude of items to be reviewed by an entrepreneur at the start-up in order to choose the most appropriate licensing type for his business. Given that our country's law allows entrepreneurs to license their businesses in several forms, the decision to choose between many existing possibilities is a very important one for the future good of the business. Currently in our country there are two major laws governing the licensing of a business. The first one is the republished and subsequently amended Company Law number 31/1990 and the second, the Government Emergency Ordinance number 44/2008 regarding the economic activities of the Sole traders, Individual enterprises and Family enterprises. The Company Law number 31/1990 allows companies to choose between one of the five types of business entities that can operate in Romania: General partnership (in Romanian SNC, Limited partnership (in Romanian SCS, Limited partnerships by shares (in Romanian SCA, Joint stock company (in Romanian S.A. and Limited liability company (in Romanian S.R.L.. GEO number 44/2008 on economic activities of the Sole traders, Individual enterprises and Family enterprises regulates the licensing and the activity of a Sole traders, Individual enterprises and Family enterprises.

  9. Choose Life! Unborn Children and the Right to Life. Intermediate Level: Grades 5-6. (United States)

    National Catholic Educational Association, Washington, DC.

    This curriculum is designed to assist Catholic school teachers and parish catechists in their efforts to foster a pro-life attitude in students in grades 5 and 6. Following an introduction is the curriculum, which features six lessons. These are: (1) The miracle of life around us; (2) Respect for all life; (3) The miracle of human life; (4)…

  10. Choosing wisely-where is the choice?

    Directory of Open Access Journals (Sweden)

    Robbins RA


    Full Text Available No abstract available. Article truncated at 150 words. A little over a year ago an editorial was posted in the Southwest Journal about the Choosing Wisely campaign from the American Board of Internal Medicine and Consumer Reports (1. You may remember that Choosing Wisely announced a list of procedures or treatments that patients should question (2. In the editorial we wondered why pulmonary organizations such as the American Thoracic Society (ATS and the American College of Chest Physicians authored none of the recommendations and offered 10 suggestions. We also openly questioned if the recommendations were intended to improve patient care or reduce costs, and thus improve the profits of third party carriers. We can now report that recommendations were announced at the recent ATS meeting in Philadelphia. Seven recommendations were made for critical care and seven for pulmonary disease. Five from the critical care list and five from the pulmonary list will eventually be chosen for inclusion in …

  11. Heinz dilemma? Let the subject choose! (United States)

    Durm, M W; Pitts, S


    This description of a novel approach for studying the validity of Kohlberg's sequential and hierarchical theory of moral development involved 138 boys and 113 girls (14 to 18 years old) choosing a solution among 12 to Kohlberg's Heinz dilemma instead of being assigned one by an interviewer. The results were not supportive of the theory. The methodology of research on moral development needs to be examined.

  12. Context and Word Choosing in Translation

    Institute of Scientific and Technical Information of China (English)



    This paper has a discussion on context in relation to translation,and elaborates with examples the important role context plays in helping translators to choose the right word in the line with a specific context. Context here does not only refer to the linguistic context,but also the non-linguistic context,which can be further subcategorized as situational and cultural context.

  13. Biocatalysis: synthesis of chiral intermediates for drugs. (United States)

    Patel, Ramesh N


    Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand for the bulk preparation of drug substances and agricultural products. There has been an increasing awareness of the enormous potential of the use of microorganisms and microorganism-derived enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivities. In this article, biocatalytic processes are described for the synthesis of chiral intermediates for drugs.

  14. Relation between hard photon production and impact parameter in heavy ion collisions at intermediate energies; Dependance de la production de photons durs avec le parametre d`impact dans les collisions entre ions lourds aux energies intermediaires

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Garcia, G.


    Hard photons produced in heavy-ions collisions at intermediate energies have been used in order to study hot and compresses nuclear matter created in these collisions (at Ganil). It was found that Bremsstrahlung radiation emitted in np collisions is the main mechanism of hard-photon production for the whole range of impact parameter. Moreover, it was observed a substantial decrease of the hardness of hard-photon spectrum. The BUU model reproduces very well the experimental results, showing that the hardness of the spectrum reflects, mainly, nuclear-matter compression in the first stage of the collision. A new method was developed to measure the density of the nuclear matter created at the beginning of the collision. BUU results and some experimental evidences point out that a significant contribution of hard photons are produced in the last stage of the collision: thermal hard photons. These photons are sensitive to the density oscillation of nuclear matter. Its production cross-section will constitute a measurement of the compressibility of nuclear matter and its spectrum a measure of the temperature. (from author) 64 figs., 60 refs.


    Directory of Open Access Journals (Sweden)

    Vaduva Cecilia


    Full Text Available Strategic choosing refers to making decisions (selecting the strategic option related to the future of the enterprise and the ways it respond to the action of certain pressure and influence factors identified by analysis and strategic diagnosis. The clear definition of the enterprise objectives is very important from the viewpoint of the business types where it is involved and of the connections existent between them (by means of the SBU mix. But, the successful development of the strategies should consider the fact that they cannot be built only on the existent financial resources, but also on the development of these resources.

  16. Diapers: What do Parents Choose and Why?


    Shanon, Amir; Feldman, William; JAMES, WILLIAM; Dulberg, Corinne


    Self-administered questionnaires about diaper choices and the reasons for such choices were completed by 600 parents of children younger than two years of age attending a hospital walk-in clinic or the private office of one of four pediatricians. Only 2.7% of the parents used cloth alone; another 15% used both cloth and disposable diapers; a further 18% reported having used cloth at some time. Convenience and rash prevention were reasons for choosing disposable diapers. Those who used only cl...

  17. How to choose the right financial planner. (United States)

    Maurer, Timothy J


    An "economic Pearl Harbor." That is how the world's most famous investor, Warren Buffett, described what we have gone through and what we're still going through.' Even the most optimistic appraisals of our economic conditions suggest that we are likely to feel the effects of the Great Recession through the decade we recently entered. Healthcare reform, in whatever form, may also create change in your medical practice ranging from immaterial to revolutionary. To whom should you turn to ensure that your personal economy survives and thrives, especially in these times? A financial planner, possibly, but what is a financial planner, how do you choose one, and what sort of service should you expect?

  18. Bacterial intermediate filaments

    DEFF Research Database (Denmark)

    Charbon, Godefroid; Cabeen, M.; Jacobs-Wagner, C.


    Crescentin, which is the founding member of a rapidly growing family of bacterial cytoskeletal proteins, was previously proposed to resemble eukaryotic intermediate filament (IF) proteins based on structural prediction and in vitro polymerization properties. Here, we demonstrate that crescentin...

  19. Intermediate algebra a textworkbook

    CERN Document Server

    McKeague, Charles P


    Intermediate Algebra: A Text/Workbook, Second Edition focuses on the principles, operations, and approaches involved in intermediate algebra. The publication first takes a look at basic properties and definitions, first-degree equations and inequalities, and exponents and polynomials. Discussions focus on properties of exponents, polynomials, sums, and differences, multiplication of polynomials, inequalities involving absolute value, word problems, first-degree inequalities, real numbers, opposites, reciprocals, and absolute value, and addition and subtraction of real numbers. The text then ex

  20. Intermediate algebra & analytic geometry

    CERN Document Server

    Gondin, William R


    Intermediate Algebra & Analytic Geometry Made Simple focuses on the principles, processes, calculations, and methodologies involved in intermediate algebra and analytic geometry. The publication first offers information on linear equations in two unknowns and variables, functions, and graphs. Discussions focus on graphic interpretations, explicit and implicit functions, first quadrant graphs, variables and functions, determinate and indeterminate systems, independent and dependent equations, and defective and redundant systems. The text then examines quadratic equations in one variable, system

  1. Statistical and off-equilibrium production of fragments in heavy ion collisions at intermediate energies; Production statistique et hors-equilibre de fragments dans les collisions d`ions lourdes aux energies intermediaires

    Energy Technology Data Exchange (ETDEWEB)

    Bocage, Frederic [Lab. de Physique Corpusculaire, Caen Univ., 14 - Caen (France)


    The study of reaction products, fragments and light charged particles, emitted during heavy-ion collisions at intermediate energies has shown the dominant binary dissipative character of the reaction, which is persisting for almost all impact parameters. However, in comparison with this purely binary process, an excess of nuclear matter is observed in-between the quasi-projectile and the quasi-target. To understand the mechanisms producing such an excess, this work studies more precisely the breakup in two fragments of the quasi-projectile formed in Xe+Sn, from 25 to 50 MeV/u, and Gd+C and Gd+U at 36 MeV/u. The data were obtained during the first INDRA experiment at GANIL. The angular distributions of the two fragments show the competition between statistical fission and non-equilibrated breakup of the quasi-projectile. In the second case, the two fragments are aligned along the separation axis of the two primary partners. The comparison of the fission directions and probabilities with statistical models allows us to measure the fission time, as well as the angular momentum, temperature and size of the fissioning residue. The relative velocities are compatible with Coulomb and thermal effects in the case of statistical fission and are found much higher for the breakup of a non-equilibrated quasi-projectile, which indicates that the projectile was deformed during interaction with the target. Such deformations should be compared with dynamical calculations in order to constrain the viscosity of nuclear matter and the parameters of the nucleon-nucleon interaction, (author) 148 refs., 77 figs., 11 tabs.

  2. Choosing a Commercial Broiler Strain Based on Multicriteria Decision Analysis

    Directory of Open Access Journals (Sweden)

    Hosseini SA


    Full Text Available With the complexity and amount of information in a wide variety of comparative performance reports in poultry production, making a decision is difficult. This problem is overcomed only when all data can be put into a common unit. For this purpose, five different decision making analysis approaches including  Maximin, Equally likely, Weighted average, Ordered weighted averages and Technique for order preference by similarity to ideal solution were used to choose the best broiler strain among three ones based on their comparative performance and carcass characteristics. Commercial broiler strains of 6000 designated as R, A, and C (each strain 2000 were randomly allocated into three treatments of five replicates. In this study, all methods showed similar results except Maximin approach. Comparing different methods indicated that strain C with the highest world share market has the best performance followed by strains R and A.

  3. Higgs Pair Production: Choosing Benchmarks With Cluster Analysis

    CERN Document Server

    Dall'Osso, Martino; Gottardo, Carlo A; Oliveira, Alexandra; Tosi, Mia; Goertz, Florian


    New physics theories often depend on a large number of free parameters. The precise values of those parameters in some cases drastically affect the resulting phenomenology of fundamental physics processes, while in others finite variations can leave it basically invariant at the level of detail experimentally accessible. When designing a strategy for the analysis of experimental data in the search for a signal predicted by a new physics model, it appears advantageous to categorize the parameter space describing the model according to the corresponding kinematical features of the final state. A multi-dimensional test statistic can be used to gauge the degree of similarity in the kinematics of different models; a clustering algorithm using that metric may then allow the division of the space into homogeneous regions, each of which can be successfully represented by a benchmark point. Searches targeting those benchmark points are then guaranteed to be sensitive to a large area of the parameter space. In this doc...

  4. Methods for Choosing Buffer Size in Tandem Production Operations (United States)


    DRSMC Craig Colledge -IRP George Cowan -IRD Mohan Devaraju -IRI-M Bob Gunnare -IRI Jim Kilar -IRI Matt Craighead -PP Don Eckman -6AS Fred...Northey -SAS Jim Wasson -SAS Herman Michels -SAL Norm Trier -SAL Byron White -SAA Don Wahlgren -ASM Brian Walters -ASA Dennis Winegar -LEM Paul ...Woodhouse -OPP Dick Heider -OPI Sandi Paul -LEP-L 39 ANNEXES COMPUTER SOURCE PROGRAMS The program listings in these annexes are written in

  5. How to Choose the Best Skin Care Products (United States)

    ... Lines and Forehead Furrows Hair Loss Hyperpigmentation Melasma Sagging Skin Scars Skin Growths Skin Lesions Spider Veins ... Lines and Forehead Furrows Hair Loss Hyperpigmentation Melasma Sagging Skin Scars Skin Growths Skin Lesions Spider Veins ...

  6. Motivations for choosing various food groups based on individual foods. (United States)

    Phan, Uyen T X; Chambers, Edgar


    Understanding "why people eat what they eat" is important for improving the lives of people around the world by helping provide industrial and social solutions for people to have greater pleasure and health from the foods they choose. The objective of this study was to investigate the motivations behind everyday choices of different food groups using a bottom-up approach that targeted the specific choices of foods and beverages people consumed at various times of a day. This study was conducted using an online survey included questions related to demographics, the most recent meal including specific food choices, and a slightly modified Eating Motivation Surveys (2 motivations were added, and Check-All-That-Apply procedure was used), which contained 50 sub-scales to measure 17 motivations including such topics as Liking, Pleasure, Convenience, Health, Price, Variety Seeking etc. A total of 198 participants have completed the surveys. Data were analyzed by Correspondence Analysis. Liking was found to be the strongest motivation that drove people to select all sorts of foods. Need and Hunger and Convenience were the main motivations for baked products, "fast" foods, sausages and meats, and snack foods while Health and Weight Control were found to be the main driving factors for vegetables, fruits & fruit juices, nuts, seeds, dairy & egg, and poultry products. Sweets were linked to Pleasure. For beverages, people were motivated most by Heath and Weight Control to choose water and tea. Coffee was used due to Habits; soda was because of Pleasure and alcoholic was for socialization purposes. This study provided developers, marketers, health educators, etc. With a new method to understand food choice in order to promote better eating.

  7. Fuel from Tobacco and Arundo Donax: Synthetic Crop for Direct Drop-in Biofuel Production through Re-routing the Photorespiration Intermediates and Engineering Terpenoid Pathways

    Energy Technology Data Exchange (ETDEWEB)



    PETRO Project: Biofuels offer renewable alternatives to petroleum-based fuels that reduce net greenhouse gas emissions to nearly zero. However, traditional biofuels production is limited not only by the small amount of solar energy that plants convert through photosynthesis into biological materials, but also by inefficient processes for converting these biological materials into fuels. Farm-ready, non-food crops are needed that produce fuels or fuel-like precursors at significantly lower costs with significantly higher productivity. To make biofuels cost-competitive with petroleum-based fuels, biofuels production costs must be cut in half.

  8. Photocatalytic degradation of cylindrospermopsin under UV-A, solar and visible light using TiO2. Mineralization and intermediate products. (United States)

    Fotiou, Theodora; Triantis, Theodoros; Kaloudis, Triantafyllos; Hiskia, Anastasia


    Cyanobacteria (blue-green algae) are considered an important water quality problem, since several genera can produce toxins, called cyanotoxins that are harmful to human health. Cylindrospermopsin (CYN) is an alkaloid-like potent cyanotoxin that has been reported in water reservoirs and lakes worldwide. In this paper the removal of CYN from water by UV-A, solar and visible light photocatalysis was investigated. Two different commercially available TiO2 photocatalysts were used, i.e., Degussa P25 and Kronos-vlp7000. Complete degradation of CYN was achieved with both photocatalysts in 15 and 40 min under UV-A and 40 and 120 min under solar light irradiation, for Degussa P25 and Kronos vlp-7000 respectively. Experiments in the absence of photocatalysts showed that direct photolysis was negligible. Under visible light irradiation only the Kronos vlp-7000 which is a visible light activated catalyst was able to degrade CYN. A number of intermediates were identified and a complete degradation pathway is proposed, leading to the conclusion that hydroxyl radical attack is the main mechanism followed. TOC and inorganic ions (NO2-, NO3-, SO4(2-) and NH4+) determinations suggested that complete mineralization of CYN was achieved under UV-A in the presence of Degussa P25.

  9. Intermediate dosimetric quantities. (United States)

    Kellerer, A M; Hahn, K; Rossi, H H


    The transfer of energy from ionizing radiation to matter involves a series of steps. In wide ranges of their energy spectra photons and neutrons transfer energy to an irradiated medium almost exclusively by the production of charged particles which ionize and thereby produce electrons that can ionize in turn. The examination of these processes leads to a series of intermediate quantities. One of these is kerma, which has long been employed as a measure of the energy imparted in the first of the interactions. It depends only on the fluence of uncharged particles and is therefore--unlike absorbed dose and electron fluence--insensitive to local differences of receptor geometry and composition. An analogous quantity for charged-particle fields, cema (converted energy per unit mass), is defined, which quantifies the energy imparted in terms of the interactions of charged particles, disregarding energy dissipation by secondary electrons. Cema can be expressed as an integral over the fluence of ions times their stopping power. However, complications arise when the charged particles are electrons, and when their fluence cannot be separated from that of the secondaries. The resulting difficulty can be circumvented by the definition of reduced cema. This quantity corresponds largely to the concept employed in the cavity theory of Spencer and Attix. In reduced cema not all secondary electrons but all electrons below a chosen cutoff energy, delta, are considered to be absorbed locally. When the cutoff energy is reduced, cema approaches absorbed dose and thereby becomes sensitive to highly local differences in geometry or composition. With larger values of delta, reduced cema is a useful parameter to specify the dose-generating potential of a charged-particle field 'free in air' or in vacuo. It is nearly equal to the mean absorbed dose in a sphere with radius equal to the range of electrons of energy delta. Reduced cema is a function of the fluence at the specified location at




  11. Decision Support System to Choose Digital Single Lens Camera with Simple Additive Weighting Method

    Directory of Open Access Journals (Sweden)

    Tri Pina Putri


    Full Text Available One of the technologies that evolve today is Digital Single Lens Reflex (DSLR camera. The number of products makes users have difficulties to choose the appropriate camera based on their criteria. Users may utilize several ways to help them choosing the intended camera such as using magazine, internet, and other media. This paper discusses about a web based decision support system to choose cameras by using SAW (Simple Additive Weighting method in order to make the decision process more effective and efficient. This system is expected to give recommendations about the camera which is appropriate with the user’s need and criteria based on the cost, the resolution, the feature, the ISO, and the censor. The system was implemented by using PHP and MySQL. Based on the result of questionnaire distributed to 20 respondents, 60% respondents agree that this decision support system can help users to choose the appropriate camera DSLR in accordance with the user’s need, 60% of respondents agree that this decision support system is more effective to choose DSLR camera and 75% of respondents agree that this system is more efficient. In addition, 60.55% of respondents agree that this system has met 5 Es Usability Framework.

  12. Evaluation of antioxidant enzymes activities and identification of intermediate products during phytoremediation of an anionic dye (C.I. Acid Blue 92) by pennywort (Hydrocotyle vulgaris). (United States)

    Vafaei, Fatemeh; Movafeghi, Ali; Khataee, Alireza


    The potential of pennywort (Hydrocotyle vulgaris) for phytoremediation of C.I. Acid Blue 92 (AB92) was evaluated. The effects of various experimental parameters including pH, temperature, dye concentration and plant weight on dye removal efficiency were investigated. The results showed that the optimal condition for dye removal were pH 3.5 and temperature 25 degree C. Moreover, the absolute dye removal enhanced with increase in the initial dye concentration and plant weight. Pennywort showed the same removal efficiency in repeated experiments (four runs) as that obtained from the first run (a 6-day period). Therefore, the ability of the plant in consecutive removal of AB92 confirmed the biodegradation process. Accordingly, a number of produced intermediate compounds were identified. The effect of treatment on photosynthesis and antioxidant defense system including superoxide dismutase, peroxidase and catalase in plant roots and leaves were evaluated. The results revealed a reduction in photosynthetic pigments content under dye treatments. Antioxidant enzyme responses showed marked variations with respect to the plant organ and dye concentration in the liquid medium. Overall, the increase in antioxidant enzyme activity under AB92 stress in the roots was much higher than that in the leaves. Nevertheless, no significant increase in malondialdehyde content was detected in roots or leaves, implying that the high efficiency of antioxidant system in the elimination of reactive oxygen species. Based on these results, pennywort was founded to be a capable species for phytoremediation of AB92-contaminated water, may be effective for phytoremediation dye-contaminated polluted aquatic ecosystems.

  13. General aspects for choosing the DICOM viewer

    Directory of Open Access Journals (Sweden)

    Afshin Niakan


    Full Text Available Most of physicians choose the PACS by its viewer. DICOM Image viewers, the programs that run in workstations, facilitate accessing to the digital im-ages via a DICOM network. A good workstation should be equipped with professional monitors and other hardware requirements. A wide range of DICOM image viewers are available from simple 2D viewers which offer means of manipulating the im-ages (rotate, zoom, brightness, contrast and others to 3D or 4D programs with sophisticated features such as multimodality image fusion, vessel segmentation and computer aided diagnostic tools."nThese programs can be categorized to client-based and web-based viewers. Despite the client-based viewers, which are heavy-weighted programs, equipped with strong features, web-based viewers are usually light-weighted with essential imaging features and suitable for TeleRadiology. Accessing to the digital images via the Internet is the main propose behind a web-based viewer. Web-based viewers may be used for remote consulting when a city or region lacks of native specialists."nAn image viewer as a part of PACS should be in conformance with DICOM standard as communication protocol instated of customized networking. This issue allows the viewer to communicate with any DICOM server and operate as an independent module. Structured Report (SR editor is an essential part of a DICOM viewer. This kind of reporting benefits the archiving system because of small data size in comparison with keeping reports as scanned images or Secondary Capture Images (SC. Also, connection of DICOM viewer to RIS/HIS is important and as our previous experiences in RIS/HIS we connected Payvand DICOM viewer to the RIS/HIS. "nPayvand DICOM viewer has a lot of features and abilities, but for reaching to the high performance image processing by BARCO-EPD collaboration contract, we integrated our DICOM viewer to the VOXAR 3D and now our users have advanced 3D, vessel, cardiac and colon processing, PET CT

  14. Patient values and preferences when choosing anticoagulants

    Directory of Open Access Journals (Sweden)

    Palacio AM


    Full Text Available Ana M Palacio,1–3 Irene Kirolos,2,3 Leonardo Tamariz1–3 1The Department of Medicine, Miller School of Medicine, University of Miami, 2The Veterans Affairs Medical Center, Miami, FL, USA; 3Division of Public Health Sciences, University of Miami, Miami, Florida, USA Background: New oral anticoagulants have similar efficacy and lower bleeding rates compared with warfarin. However, in case of bleeding there is no specific antidote to reverse their effects. We evaluated the preferences and values of anticoagulants of patients at risk of atrial fibrillation and those who have already made a decision regarding anticoagulation.Methods: We conducted a cross-sectional study of Veterans in the primary care clinics and the international normalized ratio (INR laboratory. We developed an instrument with patient and physician input to measure patient values and preferences. The survey contained a hypothetical scenario of the risk of atrial fibrillation and the attributes of each anticoagulant. After the scenario, we asked participants to choose the option that best fits their preferences. The options were: 1 has better efficacy at reducing risk of stroke; 2 has been in the market for a long period of time; 3 has an antidote to reverse the rare case of bleeding; 4 has better quality of life profile with no required frequent laboratory tests; or 5 I want to follow physician recommendations. We stratified our results by those patients who are currently exposed to anticoagulants and those who are not exposed but are at risk of atrial fibrillation.Results: We approached 173 Veterans and completed 137 surveys (79% response rate. Ninety subjects were not exposed to anticoagulants, 46 reported being on warfarin, and one reported being on dabigatran at the time of the survey. Ninety-eight percent of subjects stated they would like to participate in the decision-making process of selecting an anticoagulant. Thirty-six percent of those exposed and 37% of those

  15. Protect Your Heart: Choose Healthy Fats (United States)

    ... in some snacks, cookies, pies, and other foods) • saturated fat (found in whole milk products, fatty meats, dark ... and blood vessels: • Eat less foods high in saturated fat and trans fat. Instead eat foods with healthy ...

  16. Prospects for multivariate classification of a pharmaceutical intermediate with near-infrared spectroscopy as a process analytical technology (PAT) production control supplement. (United States)

    Märk, Julia; Andre, Max; Karner, Martin; Huck, Christian W


    NIR spectroscopy was applied to develop a fast and reliable quality control system for a pharmaceutical substance to support information obtained through PAT surveillance of its manufacturing process. After calculating different quantitative calibrations of the substance's key quality parameters, a general classification model has been derived to capture the over-all product grade. The final spectral quality conformity model consisting of 96 representative batches - covering high process variability - was sensibilized toward five important quality parameters by their incorporation as PLS responses. The model characteristics were extensively investigated and interpreted to derive a reasonable limit for the reduced chemometric summary quality measure (Hotteling's T(2)). Through this parameter new batches can be assessed easily by their NIR spectra, using versatile test batches for confirmation. Different sets of good quality batches, bad production batches beyond the respective chemical quality limit and synthetic batches exactly at the limit could be accurately assigned through their multivariate evaluation to a large extend. However, high model sensitivity to non-relevant product properties can lead to limited applicability of the model. This may be caused by restricted bandwidth of quality parameters in production environment for calibration, repack effects and high process instability.

  17. Bricolage: Re-Discovering History through Intermediality and Performance. A Report on the UCT/CityVarsity Production of "A Day, Across" at the Cape Town Fringe 2014 (United States)

    Muftic, Sanjin


    "A Day, Across," performed by the CityVarsity School of Creative Arts at the Cape Town Fringe 2014, was a student production that investigated the link between the youth of South Africa and the centennial of the start of World War I. This paper presents a brief analysis of the rehearsal process as well as certain performance sequences in…

  18. Choosing Your China Structure: Foreign-Invested Commercial Enterprises

    Institute of Scientific and Technical Information of China (English)



    When choosing an appropriate invest-When choosing an appropriate investment vehicle in China,many factors must be considered,as these will lead to different legal and tax considerations.Once you’ve clearly defined the needs and goals for your

  19. Choose Privacy Week: Educate Your Students (and Yourself) about Privacy (United States)

    Adams, Helen R.


    The purpose of "Choose Privacy Week" is to encourage a national conversation to raise awareness of the growing threats to personal privacy online and in day-to-day life. The 2016 Choose Privacy Week theme is "respecting individuals' privacy," with an emphasis on minors' privacy. A plethora of issues relating to minors' privacy…

  20. Majorizational Choosing of SeveralDifferent Fuzzy Counter Operator

    Institute of Scientific and Technical Information of China (English)


    Different fuzzy reasoning methods were made by choosing different fuzzy operater. This article generally introduced the basic structure of fuzzy controller ,and gave several different fuzzy controllers ,and compared and analyzed different fuzzy counters in theory and computer simulating control and realized majorizational choosing of several fuzzy counters.

  1. Choosing and Using Images in Environmental Science Education (United States)

    Muthersbaugh, Debbie Smick


    Although using images for teaching has been a common practice in science classrooms (Gordon & Pea, 1995) understanding the purpose or how to choose images has not typically been intentional. For this dissertation three separate studies relating to choosing and using images are prepared with environmental science in mind. Each of the studies…

  2. Digging up Classroom Dollars on DonorsChoose (United States)

    Curriculum Review, 2006


    Back in 2000, Charles Best was teaching at Wings Academy, an alternative high school in the Bronx, when he got the idea for a Web site where teachers could solicit donations for class projects. With help from his students, soon was born. Last year, the site won's Nonprofit Innovation Award. So far, DonorsChoose has…

  3. SAFER STERILE COMPOUNDING: Choosing and Using Disinfectants for the Cleanroom. (United States)

    Kastango, Eric S; Douglass, Kate; Patel, Kedar; Givehchi, Babak; Brister, Paul; Postlewaite, Jay; Taraban, Laura


    Compounders worldwide are responsible for ensuring that the sterile preparations they dispense are pure, potent, and safe. To achieve that result, proper cleaning and disinfection of International Organization for Standardization controlled environments must occur. Because those tasks must be performed according to established standards, the compounding pharmacist must research regulatory requirements and appropriate products for use. In this report, we focus on U.S. regulations, guiding entities, and effective products that enable compliance with the increasingly stringent procedures required for pharmaceutical compounding. We also review cleaning and disinfecting processes, discuss the importance of correctly choosing and using disinfectants and/ or sporicidal disinfectants with surface claims in the cleanroom, and provide answers to questions frequently asked by staff who use those agents. In addition, we profile specific disinfectants that are compliant with UnitedStates Pharmacopeia Chapter and current good manufacturing practice standards. Biological safety cabinets and compounding aseptic containment isolators must undergo an additional process that deactivates hazardous drug residues and removes them from the interior surfaces of those devices before they are cleaned and disinfected, but that discussion is beyond the scope of this article.

  4. Economic and Environmental Assessment of Switchgrass Production on High-Fertility Soil and an Assessment of Anaerobic Digests as an Intermediate Market for Switchgrass

    Energy Technology Data Exchange (ETDEWEB)

    Rhykerd, Robert [Illinois State Univ., Normal, IL (United States); Bierma, Thomas [Illinois State Univ., Normal, IL (United States); Jin, Guang [Illinois State Univ., Normal, IL (United States); Walker, Paul [Illinois State Univ., Normal, IL (United States)


    This project had two parts. Part 1 was an economic and environmental assessment of switchgrass production on high-fertility soil, and included an assessment of the effects of field irrigation with treated municipal wastewater (Studies A,C, and E in Final Agreement). Part 2 was an assessment of methods to enhance anaerobic digestion of switchgrass, and included evaluation of several other potential biomass feedstocks (Studies B and D in Final Agreement). Results from Part 1 demonstrated that switchgrass does not compete economically against a corn and soybean rotation on highly productive soils. All four varieties of switchgrass lost money while corn and soybeans were profitable in all four years of this study. Breakeven prices for the four switchgrass varieties were calculated using production costs. The installation of a center pivot irrigation system had minimal impact on crop production and corn and soybean production remained profitable in the year the irrigator was installed. Because of drought and delays in installing the wastewater treatment plant, the irrigation system was not used until year 4 of this study. Therefore, longer term studies evaluating multiple year studies on the impact of irrigation on switchgrass are warranted. Results from irrigating with treated municipal wastewater showed no negative impact on soil quality. Results from Part 2 demonstrated that anaerobic digestion (AD) of switchgrass could be significantly enhanced using low heat (100oC) and mild caustic pretreatment without fine-grinding. Heat for pretreatment could be available from biogas-based combined heat and power (CHP) systems. In bench-top digesters simulating municipal wastewater treatment AD, methane production of coarse-ground switchgrass increased over 20-fold with pretreatment compared to untreated switchgrass. Bench-top studies simulating dairy-based AD also found high specific methane yield, but even untreated switchgrass digested reasonably well, indicating the value of

  5. Whom to Choose as License Partner?

    DEFF Research Database (Denmark)

    Laursen, Keld; Reichstein, Toke; Trombini, Giulia


    This paper investigates the matching of firms on the market for technology. The paper forwards two dimensions along which license formation occurs: technology and product-market. Both sides of the market search for a partner representing potential for high technology synergies to maximize licensing...... benefits and obviate issues related to technology transfer and knowledge recombination. At the same time, firms wish to select a partner operating in a different product market to minimize competitive downside issues and to access other product markets, skills and resources. We contend interdependence...... between technology and market forces: if partners are market distant, the likelihood of technology license contractual partnership decreases with partners’ technological distance. Using data on the formation of license partnerships in the global biopharmaceutical industry over the period 1994...

  6. The Intermediate Neutrino Program

    CERN Document Server

    Adams, C; Ankowski, A M; Asaadi, J A; Ashenfelter, J; Axani, S N; Babu, K; Backhouse, C; Band, H R; Barbeau, P S; Barros, N; Bernstein, A; Betancourt, M; Bishai, M; Blucher, E; Bouffard, J; Bowden, N; Brice, S; Bryan, C; Camilleri, L; Cao, J; Carlson, J; Carr, R E; Chatterjee, A; Chen, M; Chen, S; Chiu, M; Church, E D; Collar, J I; Collin, G; Conrad, J M; Convery, M R; Cooper, R L; Cowen, D; Davoudiasl, H; De Gouvea, A; Dean, D J; Deichert, G; Descamps, F; DeYoung, T; Diwan, M V; Djurcic, Z; Dolinski, M J; Dolph, J; Donnelly, B; Dwyer, D A; Dytman, S; Efremenko, Y; Everett, L L; Fava, A; Figueroa-Feliciano, E; Fleming, B; Friedland, A; Fujikawa, B K; Gaisser, T K; Galeazzi, M; Galehouse, D C; Galindo-Uribarri, A; Garvey, G T; Gautam, S; Gilje, K E; Gonzalez-Garcia, M; Goodman, M C; Gordon, H; Gramellini, E; Green, M P; Guglielmi, A; Hackenburg, R W; Hackenburg, A; Halzen, F; Han, K; Hans, S; Harris, D; Heeger, K M; Herman, M; Hill, R; Holin, A; Huber, P; Jaffe, D E; Johnson, R A; Joshi, J; Karagiorgi, G; Kaufman, L J; Kayser, B; Kettell, S H; Kirby, B J; Klein, J R; Kolomensky, Yu G; Kriske, R M; Lane, C E; Langford, T J; Lankford, A; Lau, K; Learned, J G; Ling, J; Link, J M; Lissauer, D; Littenberg, L; Littlejohn, B R; Lockwitz, S; Lokajicek, M; Louis, W C; Luk, K; Lykken, J; Marciano, W J; Maricic, J; Markoff, D M; Caicedo, D A Martinez; Mauger, C; Mavrokoridis, K; McCluskey, E; McKeen, D; McKeown, R; Mills, G; Mocioiu, I; Monreal, B; Mooney, M R; Morfin, J G; Mumm, P; Napolitano, J; Neilson, R; Nelson, J K; Nessi, M; Norcini, D; Nova, F; Nygren, D R; Gann, G D Orebi; Palamara, O; Parsa, Z; Patterson, R; Paul, P; Pocar, A; Qian, X; Raaf, J L; Rameika, R; Ranucci, G; Ray, H; Reyna, D; Rich, G C; Rodrigues, P; Romero, E Romero; Rosero, R; Rountree, S D; Rybolt, B; Sanchez, M C; Santucci, G; Schmitz, D; Scholberg, K; Seckel, D; Shaevitz, M; Shrock, R; Smy, M B; Soderberg, M; Sonzogni, A; Sousa, A B; Spitz, J; John, J M St; Stewart, J; Strait, J B; Sullivan, G; Svoboda, R; Szelc, A M; Tayloe, R; Thomson, M A; Toups, M; Vacheret, A; Vagins, M; Van de Water, R G; Vogelaar, R B; Weber, M; Weng, W; Wetstein, M; White, C; White, B R; Whitehead, L; Whittington, D W; Wilking, M J; Wilson, R J; Wilson, P; Winklehner, D; Winn, D R; Worcester, E; Yang, L; Yeh, M; Yokley, Z W; Yoo, J; Yu, B; Yu, J; Zhang, C


    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summ...

  7. The Intermediate Neutrino Program

    Energy Technology Data Exchange (ETDEWEB)

    Adams, C.; et al.


    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop.

  8. Formation of diphenylphosphanylbutadienyl complexes by insertion of two P-coordinated alkynylphosphanes into a PtbondC6F5 bond: detection of intermediate and reaction products. (United States)

    Ara, Irene; Forniés, Juan; García, Ana; Gómez, Julio; Lalinde, Elena; Moreno, M Teresa


    complexes are unstable in solution evolving firstly, through an unexpected formal 4-1 R (Ph, Tol) migration, to the intermediate diphosphanylbutadienyl isomer derivatives [Pt(C(6)F(5))(S)mu-[C(C(6)F(5))doublebondC(PPh(2))C(PPh(2))doublebondC(R)(2)]M(C(6)F(5))(2)] (16, 18) (X-ray, R=Ph, M=Pt) and, finally, to 1-pentafluorophenyl-2,3-bis(diphenylphosphanyl)naphthalene mononuclear complexes (17, 19) by annulation of a phenyl or tolyl group.

  9. Quantitative Analysis of Intermediate of Cartap and Its by-Product by HPLC%杀螟丹中间体硫氰化物及其异构体的高效液相色谱分析

    Institute of Scientific and Technical Information of China (English)

    于观平; 闫涛; 王素华; 李正名


    [Aims] The aim is to establish a method for quantitative analysis of intermediate of cartap (N,N-dimethyl-1,3-dithiocyanatopropan-2-amine) and its by-product (N,N-dimethyl-2,3-dithiocyanatopropan-l-amine) by HPLC.[Results] The liquid chromatography condition was as follows: mobile phase was acetonitrile-water (50:50, by vol)on Sinochrom ODS-BP C18 column at a flow rate of 1.0 mL/min, UV detector wavelength was 254 nm and injection volume was 10.0 μL. The quantitative analysis was caried out with the external standard method. The linear correlation coefficient was over 0.999. The detection limit was 5.1-17.4 mg/L. The average recovery ratios for intermediate of cartap and its by-product were 103.2-105.5% and 102.4-106.1% respectively. [Conclusions] The described method was simple with good repeatability and separation and could be used for the quality control of the intermediate of cartap.%[目的]建立杀螟丹中间体硫氰化物2-N,N-二甲胺基-1,3-二硫氰基丙烷和其异构体1-N,N-二甲胺基-2.3-二硫氰基丙烷的高效液相色谱分析方法.[结果]液相色谱条件:流动相为乙腈-水(体积比50:50),流速1.0 mL/min,Sinochrom ODS-BP C柱,紫外可变波长检测器,检测波长254 nm.外标法对硫氰化物和其异构体进行定量分析,线性相关系数大于0.999,平均回收率分别为103.2%~105.5%和102.4%~106.1%.[结论]该法简便、重复性好、各成分分离良好,可用于杀螟丹中间体的含量分析.

  10. Choosing an expected sun protection factor value. (United States)

    Sica, John R; Caswell, Michael


    Sun protection factor, SPF, is a measure of the efficacy of a topical sunscreen product; the higher the SPF, the greater the blockage of ultraviolet-induced erythema. While there are several methods to determine SPF, the Food and Drug Administration (FDA) methods are unique. The FDA methods define the label SPF value as the largest whole integer after subtracting an "A" value from the mean SPF. The A value, composed of the product of the upper 5% point of the t-distribution and the standard deviation (SD), divided by √(n), where n equals the number of subjects, has a significant impact on the label SPF value. Two examples explore this impact. Development of strategies to mitigate the impact of A using expected SPF values are explored using historical clinical trial data. A more enlightened choice of expected SPF values is shown to lead to higher label SPF values.

  11. Intermediate-Mass Black Holes

    CERN Document Server

    Miller, M C


    The mathematical simplicity of black holes, combined with their links to some of the most energetic events in the universe, means that black holes are key objects for fundamental physics and astrophysics. Until recently, it was generally believed that black holes in nature appear in two broad mass ranges: stellar-mass (roughly 3-20 solar masses), which are produced by the core collapse of massive stars, and supermassive (millions to billions of solar masses), which are found in the centers of galaxies and are produced by a still uncertain combination of processes. In the last few years, however, evidence has accumulated for an intermediate-mass class of black holes, with hundreds to thousands of solar masses. If such objects exist they have important implications for the dynamics of stellar clusters, the formation of supermassive black holes, and the production and detection of gravitational waves. We review the evidence for intermediate-mass black holes and discuss future observational and theoretical work t...

  12. Matrix Model for Choosing Green Marketing Sustainable Strategic Alternatives

    Directory of Open Access Journals (Sweden)

    Cătălina Sitnikov


    Full Text Available Green marketing examines the symbiotic role played by marketing in ensuring sustainable business, exploring issues concerning the environment and the way strategic decisions can influence it. At present, the environmental issues concern more and more the competitive approach any organization can implement. Based on this approach, organizations can gain competitive advantage by managing environmental variables and by developing and implementing green marketing strategies. Considering the importance and impact of green marketing, by using theoretical concepts and defining a set of research directions, the paper and the research conducted were focused on creating a matrix model for choosing the optimal green marketing strategy, oriented towards competitive advantage. The model is based on the correlation that can be established among the generic strategies of competitive advantage, the variables of extended marketing mix (7Ps and the green marketing strategy matrix. There are also analyzed the implications that may be generated within a company by the adoption of a green marketing strategy and its role in promoting the environmental benefits of products.

  13. Choosing a hospital: analysis of consumer tradeoffs. (United States)

    Javalgi, R G; Rao, S R; Thomas, E G


    In today's competitive health care industry, hospital administrators and marketers must determine how important various product/service attributes are to potential consumers and how those attributes influence consumer choice decisions. The authors outline an approach (the analytic hierarchy process) that can be used to assess or predict health care choice decisions by consumers. The analytic hierarchy process is a method for analyzing consumer choice behavior whereby a hierarchical structure is used to determine the relative preferences of consumers for health care alternatives. Marketing strategies based on the study findings are suggested.

  14. Cord blood mesenchymal stem cells propel human dendritic cells to an intermediate maturation state and boost interleukin-12 production by mature dendritic cells. (United States)

    van den Berk, Lieke C J; Roelofs, Helene; Huijs, Tonnie; Siebers-Vermeulen, Kim G C; Raymakers, Reinier A; Kögler, Gesine; Figdor, Carl G; Torensma, Ruurd


    Pathogen-derived entities force the tissue-resident dendritic cells (DCs) towards a mature state, followed by migration to the draining lymph node to present antigens to T cells. Bone marrow mesenchymal stem cells (MSCs) modulate the differentiation, maturation and function of DCs. In umbilical cord blood an immature MSC population was identified. Remarkably, these immature stem cells modulated DCs in a different way. Marker expression was unchanged during the differentiation of monocytes towards immature DCs (iDCs) when cocultured with cord blood MSC [unrestricted somatic stem cells (USSCs)]. The maturation to mature DCs (mDCs) was enhanced when DCs were co-cultured with USSC, as evidenced by the up-regulation of costimulatory molecules. Endocytosis of dextran by iDCs was hampered in the presence of USSCs, which is indicative for the maturation of iDCs. Despite this maturation, the migration of iDCs cocultured with USSCs appeared to be identical to iDCs cultured alone. However, USSCs increased the migration of mDCs towards CCL21 and boosted interleukin-12 production. So, USSCs mature iDCs, thereby redirecting the antigen-uptake phenotype towards a mature phenotype. Furthermore, DC maturation by lipopolysaccharide (LPS) or USSCs reflects two distinct pathways because migration was unaffected when iDCs were matured by coculture with USSCs, while it was strongly enhanced in the presence of LPS. DCs are able to discriminate the different MSC subtypes, resulting in diverse differentiation programmes.

  15. Production of poly(hydroxybutyrate-hydroxyvalerate) from waste organics by the two-stage process: focus on the intermediate volatile fatty acids. (United States)

    Shen, Liang; Hu, Hongyou; Ji, Hongfang; Cai, Jiyuan; He, Ning; Li, Qingbiao; Wang, Yuanpeng


    The two-stage process, coupling volatile fatty acids (VFAs) fermentation and poly(hydroxybutyrate-hydroxyvalerate) (P(HB/HV)) biosynthesis, was investigated for five waste organic materials. The overall conversion efficiencies were glycerol>starch>molasses>waste sludge>protein, meanwhile the maximum P(HB/HV) (1.674 g/L) was obtained from waste starch. Altering the waste type brought more effects on VFAs composition other than the yield in the first stage, which in turn greatly changed the yield in the second stage. Further study showed that even-number carbon VFAs (or odd-number ones) had a good positive linear relationship with P(HB/HV) content of HB (or HV). Additionally, VFA producing microbiota was analyzed by pyrosequencing methods for five wastes, which indicated that specific species (e.g., Lactobacillus for protein; Ethanoligenens for starch; Ruminococcus and Limnobacter for glycerol) were dominant in the community for VFAs production. Potential competition among acidogenic bacteria specially involved to produce some VFA was proposed as well.

  16. Displays for future intermediate UAV (United States)

    Desjardins, Daniel; Metzler, James; Blakesley, David; Rister, Courtney; Nuhu, Abdul-Razak


    The Dedicated Autonomous Extended Duration Airborne Long-range Utility System (DAEDALUS) is a prototype Unmanned Aerial Vehicle (UAV) that won the 2007 AFRL Commander's Challenge. The purpose of the Commander's Challenge was to find an innovative solution to urgent warfighter needs by designing a UAV with increased persistence for tactical employment of sensors and communication systems. DAEDALUS was chosen as a winning prototype by AFRL, AFMC and SECAF. Follow-on units are intended to fill an intermediate role between currently fielded Tier I and Tier II UAV's. The UAV design discussed in this paper, including sensors and displays, will enter Phase II for Rapid Prototype Development with the intent of developing the design for eventual production. This paper will discuss the DAEDALUS UAV prototype system, with particular focus on its communications, to include the infrared sensor and electro-optical camera, but also displays, specifically man-portable.

  17. Choose More than 50 Ways to Prevent Type 2 Diabetes (United States)

    ... move more. If you are looking for a safe place to be active, contact your local parks department ... place while you watch TV. 15. Choose a place to walk that is safe, such as your local mall. 16. Get off ...



    Radu Lixandroiu; Catalin Maican


    Choosing an electronic trading platform is a very important decision when opening an online store. A suitable platform must be able to meet many of the requirements as to not confuse the user. It should provide an online business operation providing tools for managing back-office of technically. There are dozens maybe hundreds of electronic ecommerce platforms available to create an online store, so the decision to choose a platform is difficult. In this article, we tried to compare 19 of the...

  19. 带缓冲多阶段系统的生产批量与维护计划集成优化%Joint Optimization of Production Lot and Maintenance Planning in a Multi-Stage System with Intermediate Buffers

    Institute of Scientific and Technical Information of China (English)

    祝颖; 冷乔; 王丽亚; 赵世雄; 郑宇


    This paper aims to minimize the sum of production costs and maintenance costs. The age reduction factor and improvement factor in hazard rate are introduced and with the comprehensive consideration of imperfect and perfect maintenance,a complex non-linear integrated production lot-size and maintenance planning model in a multi-stage system with intermediate buffers is proposed under the assumption of operation-dependent failures.A time-based-decomposition simulated annealing algorithm is designed to solve this problem.Numerical analysis validated the performance of the model.%以最小化生产与维护总成本为目标,通过引入役龄递减因子与失效率递增因子对设备故障率演化进行建模,综合考虑完美维护、非完美维护和故障维修,建立了在带缓冲多阶段的生产系统环境下,基于加工失效假设的生产与维护集成计划模型,并设计基于时间分解的模拟退火算法求解该问题。最后,算例分析验证了模型的有效性。

  20. Simultaneous Determination of Three Flavonoids in Intermediate Product of Weisu Granules by RP-HPLC%RP-HPLC同时测定胃苏颗粒中间体中3种黄酮苷的含量

    Institute of Scientific and Technical Information of China (English)

    葛晓磊; 张欣; 李伟欣; 赵倩; 董晓弟; 李银


    Objective To develop a quantitative method for determination of naringin, hesperidin, and neohesperidin in intermediate product of Weisu Granules simultaneously. Methods Diamonsil C18 column (250 mm×4.6 mm, 5μm) was adopted. The mobile phrase is CH3OH-CH3COOH-H2O (35:4:61), with the flow rate of 1.0 mL/min. The detective wavelength was set at 283 nm. Results The linear ranges of naringin, hesperidin, and neohesperidin were 1.58-189.55, 0.37-44.57 and 0.41-48.72μg/mL, respectively. The average recoveries were in the range of 99.42%-108.16%, with RSDs not more than 2.0%. Conclusion This method is convenient and accurate, and can be used in the determination of intermediate product of Weisu Granules.%目的:建立胃苏颗粒中间体中黄酮类成分柚皮苷、橙皮苷、新橙皮苷的含量测定方法。方法采用反相高效液相色谱法(RP-HPLC),色谱柱:Diamonsil C18柱(250 mm×4.6 mm,5μm);甲醇-醋酸-水(35:4:61)为流动相,流速1.0 mL/min;检测波长283 nm。结果柚皮苷、橙皮苷、新橙皮苷线性范围分别为1.58~189.55μg/mL(r=1.0000),0.37~44.57μg/mL(r=1.0000)和0.41~48.72μg/mL(r=1.0000);加样回收率在99.42%~108.16%范围内,RSD≤2.0%。结论该方法简便、准确,具有良好的重复性和稳定性,可用于胃苏颗粒中间体中黄酮类成分的含量测定。

  1. Why do students choose English as a medium of instruction?

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer


    Taking a Bourdieusian perspective, this paper analyzes the relevance of social background and capital for choosing English as a medium of instruction (EMI). It focuses on students with a non-native English-language background in a business school setting. While proponents argue that EMI generally...... increases the employability of graduates, they do not sufficiently consider that study strategies differ substantially across social milieus and between the sexes. Failing to account for social distance to the educational system in choosing EMI can foster social inequality, and contribute...... to the reproduction of elites. Using a survey, we conduct a quasi-experiment in two identical bachelor's degree programs that differ only in their instruction language. Using structural equation modeling, we find that students from higher social strata are much more likely to choose EMI. As suggested...

  2. Sport, how people choose it: A network analysis approach. (United States)

    Ferreri, Luca; Ivaldi, Marco; Daolio, Fabio; Giacobini, Mario; Rainoldi, Alberto; Tomassini, Marco


    In order to investigate the behaviour of athletes in choosing sports, we analyse data from part of the We-Sport database, a vertical social network that links athletes through sports. In particular, we explore connections between people sharing common sports and the role of age and gender by applying "network science" approaches and methods. The results show a disassortative tendency of athletes in choosing sports, a negative correlation between age and number of chosen sports and a positive correlation between age of connected athletes. Some interesting patterns of connection between age classes are depicted. In addition, we propose a method to classify sports, based on the analyses of the behaviour of people practising them. Thanks to this brand new classifications, we highlight the links of class of sports and their unexpected features. We emphasise some gender dependency affinity in choosing sport classes.

  3. Expression of inducible nitric oxide synthase, caspase-3 and production of reactive oxygen intermediate on endothelial cells culture (HUVECs treated with P. falciparum infected erythrocytes and tumour necrosis factor-α

    Directory of Open Access Journals (Sweden)

    Loeki E. Fitri


    Full Text Available Cytoadherence of P. falciparum infected erythrocytes on endothelial cells is a key factor in development of severe malaria. This process may associated with the activation of local immune that was enhanced by tumour necrosis factor-α (TNF-α. This study was conducted to see the influence of P.falciparum infected erythrocytes cytoadherence and TNF-α treatment in inducing endothelial cells activation in vitro. inducible nitric oxide synthase (iNOS and caspase-3 expression, also reactive oxygen intermediate (ROI production were used as parameters. An Experimental laboratory study had been done to observe endothelial cells activation (HUVECs after treatment with TNF-α for 20 hours or P. falciparum infected erythrocytes for 1 hour or both of them. Normal endothelial cells culture had been used as a control. Using immunocytochemistry local immune activation of endothelial cells was determined by iNOS and caspase-3 expression. Nitro Blue Tetrazolium reduction-assay was conducted to see the ROI production semi quantitatively. inducible nitric oxide synthase expression only found on endothelial cells culture treated with P. falciparum infected erythrocytes or both P. falciparum infected erythrocytes and TNF-α. Caspase-3 expression found slightly on normal endothelial cells culture. This expression increased significantly on endothelial cells culture treated with both P.falciparum infected erythrocytes and TNF-α (p=0.000. The normal endothelial cells release low level of ROI in the presence of non-specific trigger, PMA. In the presence of P. falciparum infected erythrocytes or TNF-α or both of them, some cells showed medium to high levels of ROI. Cytoadherence of P. falciparum infected erythrocytes and TNF α treatment on endothelial cells can induce activation of local immune marked by increase inducible nitric oxide synthase and release of free radicals that cause cell damage. (Med J Indones 2006; 15:151-6 Keywords: P.falciparum ,HUVECs, TNF-α, i

  4. Picking and Choosing the ‘Sovereign’Border

    DEFF Research Database (Denmark)

    Parker, Noel; Adler-Nissen, Rebecca


    . For contemporary states the planes have become increasingly disaggregated, in the sense that they do not fall into place at one and the same border. Thus, states have to pick and choose different articulations (often inconsistently) on different planes. We illustrate these ideas with instances, present......-day and historical, of bordering. A corollary of there being more need to pick and choose is that articulations of sovereignty change. So, sovereignty is increasingly the material of ‘sovereignty games’, where sovereignty is used as a political instrument. In sum, our theory directs attention to state bordering...

  5. Evolutionary Characteristics of China's Intermediate Manufactures

    Institute of Scientific and Technical Information of China (English)

    Minsung Kang; Jeong-Dong Lee


    China's economic development is characterized by progressive integration with international production chains as an assembly producer. Japan and South Korea are the major partners providing intermediate products to China. The present paper analyzes the Chinese intermediate sector's present condition and evolutionary characteristics revealed in bilateral trade with Japan and South Korea. The analysis uses the framework of new trade theory represented by "intra-industry trade". Trade statistics from 1997 to 2004 are analyzed using the database published by the OECD. Results show that China's inter-industrial evolution is characterized by its expanding positioning in the manner of the flying geese development paradigm of Asian countries. Furthermore, intra-industrial evolution is characterized by a concentration on price competitiveness. The framework and results of the industrial analysis presented in this paper assist in the understanding of China's manufacturing evolution and of the policy-making decisions taken in the process.

  6. Dee-Mack Intermediate School (United States)

    Northwest Evaluation Association, 2012


    Frank Reliford, the Principal at Dee-Mack Intermediate since 2005, is familiar to almost every child in the community. 260 Students attend Reliford's school, and their status is a point of pride: Dee-Mack Intermediate is consistently one of the highest performing schools in the state. The change in student performance correlates to the…

  7. Welding. Performance Objectives. Intermediate Course. (United States)

    Vincent, Kenneth

    Several intermediate performance objectives and corresponding criterion measures are listed for each of nine terminal objectives for an intermediate welding course. The materials were developed for a 36-week (3 hours daily) course designed to prepare the student for employment in the field of welding. Electric welding and specialized (TIG & MIG)…

  8. Microbial/enzymatic synthesis of chiral pharmaceutical intermediates. (United States)

    Patel, Ramesh N


    Chirality is a key factor in the efficacy of many drugs; thus, the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity. In this article, biocatalytic processes for the synthesis of chiral pharmaceutical intermediates are described.

  9. Choosing a Strategy for Return-on-Investment Justification. (United States)

    Foshay, Wellesley R.


    Examines the concept of human capital, including how it is linked to strategic analysis and how it relates to four alternative models for return-on-investment (ROI). Discusses how to choose the best model for ROI justification of training or other human performance technology (HPT) interventions. (AEF)

  10. Choosing early pregnancy termination methods in Urban Mozambique

    NARCIS (Netherlands)

    E.M.H. Mitchell; A. Kwizera; M. Usta; H. Gebreselassie


    Little is known about who chooses medication abortion with misoprostol and why. Women seeking early abortion in 5 public hospitals in Maputo, Mozambique were recruited in 2005 and 2006 to explore decision-making strategies, method preferences and experiences with misoprostol and vacuum aspiration fo

  11. Still "Choosing Our Futures": How Many Apples in the Seed? (United States)

    Neal, James G.


    James Neal begins this essay with the introduction of the 1996 paper, "Choosing Our Futures," by calling it a provocation, and a call to arms for the academic library community to challenge complacency and move forward toward fundamental change. Neal writes here that in the context of extraordinary economic pressures, the early…

  12. The Experience of Choosing Nursing as a Career. (United States)

    Beck, Cheryl Tatano


    Nursing students (n=27) wrote descriptions of the experience of choosing nursing as a career. Influences included intense desire to help others, professional reward, prior work experiences, family and friends in health care occupations, observing nurses in action, something lacking in previous career choices, and fascination with science and the…

  13. Learning Basic Addition Facts from Choosing between Alternative Answers (United States)

    van Galen, Mirte S.; Reitsma, Pieter


    The acquisition of addition facts was investigated in a practice study. Participants were 103 Grade 1 children who practiced simple addition problems with three different methods: (a) writing down the answer, (b) choosing between two alternative answers, and (c) filling in the second missing addend. On a test with simple addition problems,…

  14. The Dilemma of Individual Autonomy versus Choosing Rightly (United States)

    Yehezkely, Chen


    Many important goals or values of education are tokens of either one of these two meta-goals-values: raising our children to be autonomous, or raising them to choose rightly. Thus, the conflicts between many educational goals-values are tokens of the meta-conflict between these two, and the questions of priority that such conflicts invite are…

  15. Trade Liberalization,Intermediate Input and the Quality of Export Products%贸易自由化、中间投入品与出口产品质量

    Institute of Scientific and Technical Information of China (English)



    我国出口贸易在取得巨大成就的同时,也面临着出口产品质量整体不高的严峻现实。本文正是基于这样的经济背景,从贸易自由化的视角,分析中间品和最终品贸易自由化对中国出口产品质量的影响。本文利用2001-2007年的中国微观经济数据,运用系统GMM方法实证分析了进口中间品和最终品的关税削减对出口产品质量的影响。研究发现,中间品和最终品贸易自由化显著提高了中国出口产品质量,并且中间品贸易自由化对出口产品质量的促进作用更大,进一步地,这一结论对不同方法测度的出口产品质量都较为稳健。因此继续推进和深化贸易自由化改革,对于改善我国的贸易条件和提高我国在全球价值链分工中的国际地位都是一项意义重大的政策举措。%China has made great achievements in export trade,whiie it is aiso facing the grim reaiity that the quai-ity of export products is not high. Based on the economic background,this paper empiricaiiy anaiyzes the effect of trade iiberaiization on the quaiity of export products,by appiying systematic GMM regression to the firm-ievei mi-cro data of China between 2001 and 2007. The resuit shows that trade iiberaiization has a significant positive impact on the upgrade of export products quaiity,and intermediate inputs tariff is more effective. So we shouid continue to promote and deepen the reform of trade iiberaiization,to improve Chinaˊs trade conditions and enhance the interna-tionai division status of Chinaˊs manufacturing industry in the giobai vaiue chains.

  16. Choosing R&D or advertising for competing firms in uncertain market

    Directory of Open Access Journals (Sweden)

    Bo Xie


    Full Text Available Purpose: R&D and advertising have become important means to enhance the competitiveness of firms’ products. Design an appropriate model to help the firm to make the right choice is value in supply chain.Design/methodology/approach: In considering that whether the market is completely covered or not, we build the strategy selection model for R&D and advertising for two competing firms and solve the optimal strategy.Findings and Originality/value: The research results show that when a firm does not take any measures to enhance competitiveness, another firm will neither. However when one takes measures to improve the competitiveness, another will do so, also. When two firms must choose one measure to improve the competitiveness, either in full-covered market or not full-covered market, the two firms will not choose to do advertising in step, even if the firms do not have to pay additional cost in advertising.Originality/value: In the game model, the firm could compare the own profit in different strategies. According to the above model, the firm choose the right strategy to make the profit maximize in a vertically differentiated market. And when the firm make the choice, it must think about other primary elements such as market.


    Directory of Open Access Journals (Sweden)



    Full Text Available The commercial intermediation is a complex juridical operation which includes a different number of juridical relationships that takes place between contractual partners either on a national or international level. These partners bare different naming due to their different set of rights and obligations set forth by the law or by the parties, and it is from this that the classification of the intermediation can be set forth. The commercial intermediation represents the activity that one person executes either in the name and on behalf of another person, or using its own name but on behalf of another person, or, finally, using its own name but on behalf of acting towards a common goal with the person who mandated her (the principal, in relation with who it is either a proxy or an independent intermediary, only negotiating or both negotiating and binding the principal. The purpose of the paper is to strictly define and set in order the various variations of the juridical operation that is the commercial intermediation, presented both in the light of the actual legal framework and also by reference to the New Civil Code. Also, the purpose is to highlight and systematize the contractual relationships from which the parties involved in a commercial intermediary operation may choose and the rights and obligations specific to each contract.

  18. Choosing Your China Structure:Foreign-Invested Commercial Enterprises

    Institute of Scientific and Technical Information of China (English)



    @@ When choosing an appropriate investment vehicle in China,many factors must be considered,as these will lead to different legal and tax considerations.Once you've clearly defined the needs and goals for your China investment,it is time to consider the legal form your China entity should take.Foreign investors have several choices for structuring a China enterprise: the representative office,the joint venture,the wholly foreign-owned enterprise(WFOE)and the foreign-invested commercial enterprise(FICE).These structures have different features that can help or hinder your China venture,so choosing the appropriate vehicle from the outset will be invaluable for the long-term success of any investment.Here we examine the FICE.


    Directory of Open Access Journals (Sweden)

    Radu Lixandroiu


    Full Text Available Choosing an electronic trading platform is a very important decision when opening an online store. A suitable platform must be able to meet many of the requirements as to not confuse the user. It should provide an online business operation providing tools for managing back-office of technically. There are dozens maybe hundreds of electronic ecommerce platforms available to create an online store, so the decision to choose a platform is difficult. In this article, we tried to compare 19 of the most popular open source ecommerce platforms using a mathematical model based on the platform functionalities. Each of these allows parameterization of an online store in a very short time, with some relatively low cost or close to 0.


    Directory of Open Access Journals (Sweden)

    Alexandru STĂNESCU


    Full Text Available This paper proposes an algorithm that is based on a complex analysis method that is used for choosing the configuration of a power station. The station generates electric energy and hydrogen, and serves a "green" highway. The elements that need to be considered are: energy efficiency, location, availability of primary energy sources in the area, investment cost, workforce, environmental impact, compatibility with existing systems, meantime between failure.

  1. I choose health (Elijo Salud: impacting youth through parish nursing. (United States)

    Oakley, Janet; Hoebeke, Roberta


    The 2009-2010 National Health and Nutritional Examination Survey (NHANES) found that 34% of adolescents are overweight and 18% obese. The chance of an overweight/obese adolescent becoming an overweight/obese adult by age 35 is 60%. Hispanic youth are at risk for becoming obese related to eating habits. This paper describes an intervention, I Choose Health (Elijo Salud), with Hispanic church youth.

  2. On Design of Automatic Choosing Control by Pole Placement


    高田, 等; 提, 祐樹; 八野, 知博; TAKATA, Hitoshi; Sage, Yuki; HACHINO, Tomohiro


    This paper is concerned with design of an augmented automatic choosing control (AACC) for nonlinear systems. The AACC is synthesized by smoothly uniting a set of sectionwise linear controls, in which pole placement approach is used. An observer theory is applied to it in a case that the state vector includes some unmeasurable variables directly. Control and observer's gains are obtained by the pole placement method.

  3. A comparative study of nitrite reduction by synthetic and biogenic Fe(II-III) hydroxysalts green rusts: Evidence for hydroxyl-nitrite green rust formation as an intermediate reaction product. (United States)

    Ona-Nguema, G.; Guerbois, D.; Morin, G.; Zhang, Y.; Noel, V.; Brest, J.


    -GR(Cl) led to the reduction of nitrite ions to ammonium, and that the production of ammonium depended on their Fe(II) content. XRD patterns indicated that both synthetic green rusts were fully oxidized into magnetite during the reaction with nitrite. For biogenic green rusts, the study revealed that both bio-GR(CO3)F and bio-GR(CO3)L were capable of reducing nitrite ions without ammonium production, suggesting the conversion of nitrite ions to nitrogen gas. Moreover, we provided evidence for the first time that the interactions of bio-GR(CO3)F with nitrite led to the formation of an hydroxy-nitrite green rust as a result of the incorporation of nitrite in the interlayer region of bio-GR(CO3)F; such an intercalation of nitrite ions was not observed in experiments with bio-GR(CO3)L. XRD analysis indicated that GR(NO2) was formed as an intermediate reaction product prior to the fully oxidation of GR to ferric oxyhydroxides. [1] Philips S., Laanbroek H. J. and Verstraete W. (2002). Rev. Environ. Sci. Biotechnol. 1, 115-141.

  4. Gulf of Maine intermediate water

    Energy Technology Data Exchange (ETDEWEB)

    Hopkins, T.S. (Brookhaven National Lab., Upton, NY); Garfield, N. III


    The thermohaline dynamics of the Gulf of Maine are analyzed from the two year, eight cruise, data set of Colton, Marak, Nickerson, and Stoddard (1968). Six water masses are described: the Maine Surface Water, Maine Intermediate Water, and the Maine Bottom Water as interior water masses; and the Scotian Shelf Water, the Slope Water, and the Georges Bank Water as exterior water masses. Particular attention is given to the formation and disposition of the Maine Intermediate Water. Salt balance, T-S volume, and T-S drift analyses are used to provide transport and mixing estimates for the year 1966. The Slope Water entered at depth through the Northeast Channel at a rate of 2600 km/sup 3//yr; while the Scotian Shelf Water entered the surface and intermediate layers, mostly during winter intrusions, at a rate of 5200 km/sup 3//yr. The surface and intermediate layers exported a total of 7900 km/sup 3//yr in a 3:5 ratio, respectively. The Maine Intermediate Water tends to collect over the Wilkinson Basin during the stratified season, to exit via the Great South Channel during early spring, and to exit via the Northeast Channel during spring and summer. Comparisons are made between the estimated winter heat loss of 280 Ly/d and the observed heat losses of 230 Ly/d (surface layers) and 360 Ly/d (surface and intermediate layers). A limit for the Scotian Shelf Water contribution is about -70 Ly/d. It is concluded that the Maine Intermediate Water is produced locally and that it is exported in significant quantities.

  5. A Comparative Study of EFL Teachers' and Intermediate High School Students' Perceptions of Written Corrective Feedback on Grammatical Errors (United States)

    Jodaie, Mina; Farrokhi, Farahman; Zoghi, Masoud


    This study was an attempt to compare EFL teachers' and intermediate high school students' perceptions of written corrective feedback on grammatical errors and also to specify their reasons for choosing comprehensive or selective feedback and some feedback strategies over some others. To collect the required data, the student version of…

  6. Element Yields of Intermediate-Mass Stars

    CERN Document Server

    Henry, R B C


    Intermediate mass stars occupy the mass range between 0.8-8 solar masses. In this review, evolutionary models of these stars from numerous sources are compared in terms of their input physics and predicted yields. In particular, the results of Renzini & Voli, van den Hoek & Groenewegen, and Marigo are discussed. Generally speaking, it is shown that yields of He-4, C-12, and N-14 decrease with increasing metallicity, reduced mass loss rate, and increased rotation rate. Integrated yields and recently published chemical evolution model studies are used to assess the relative importance of intermediate mass and massive stars in terms of their contributions to universal element buildup. Intermediate mass stars appear to play a major role in the chemical evolution of N-14, a modest role in the case of C-12, and a small role for He-4. Furthermore, the time delay in their release of nuclear products appears to play an important part in explaining the apparent bimodality in the distribution of damped Lyman alp...

  7. Organophosphate Poisoning and Intermediate Syndrome

    Directory of Open Access Journals (Sweden)

    Mustafa Yilmaz


    Full Text Available Toxic effects that occur after acute organophosphate poisoning (OP can manifest three phases, namely, acute cholinergic crisis, intermediate syndrome and delayed-type polyneuropathy. Clinical signs and symptoms of organophosphate poisoning depend on the accumulation of acetylcholine at the nerve junction. Organophosphate poisoning causes three main clinical findings; acute cholinergic crisis consisting of muscarinic, nicotinic and central nervous system symptoms, intermediate syndrome with recurrence of cholinergic symptoms or muscle weakness without fasciculation 24-96 hours after poisoning and delayed-type polyneuropathy that can usually occur several days or weeks after acute exposure to organic phosphorus compounds. In this article, intermediate syndrome, which is a late complication, has been reviewed. [Archives Medical Review Journal 2016; 25(1.000: 70-83

  8. Nuclear reactions at intermediate energies

    Directory of Open Access Journals (Sweden)

    Shyam Radhey


    Full Text Available In the domain of Nuclear reactions at intermediate energies, the QCD coupling constant αs is large enough (~ 0.3 - 0.5 to render the perturbative calculational techniques inapplicable. In this regime the quarks are confined into colorless hadrons and it is expected that effective field theories of hadron interactions via exchange of hadrons, provide useful tools to describe such reactions. In this contribution we discuss the application of one such theory, the effective Lagrangian model, in describing the hadronic reactions at intermediate energies whose measurements are the focus of a vast international experimental program.

  9. Categorical and nonparametric data analysis choosing the best statistical technique

    CERN Document Server

    Nussbaum, E Michael


    Featuring in-depth coverage of categorical and nonparametric statistics, this book provides a conceptual framework for choosing the most appropriate type of test in various research scenarios. Class tested at the University of Nevada, the book's clear explanations of the underlying assumptions, computer simulations, and Exploring the Concept boxes help reduce reader anxiety. Problems inspired by actual studies provide meaningful illustrations of the techniques. The underlying assumptions of each test and the factors that impact validity and statistical power are reviewed so readers can explain

  10. Therapeutic options for intermediate-advanced hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Zong-Ming Zhang; Jin-Xing Guo; Zi-Chao Zhang; Nan Jiang; Zhen-Ya Zhang; Li-Jie Pan


    Hepatocellular carcinoma (HCC) is one of the most common malignancies, ranking the sixth in the world, with 55% of cases occurring in China. Usually, patients withHCC did not present until the late stage of the disease,thus limiting their therapeutic options. Although surgical resection is a potentially curative modality for HCC,most patients with intermediate-advanced HCC are not suitable candidates. The current therapeutic modalities for intermediate-advanced HCC include: (1) surgical procedures,such as radical resection, palliative resection,intraoperative radiofrequency ablation or cryosurgical ablation, intraoperative hepatic artery and portal vein chemotherapeutic pump placement, two-stage hepatectomy and livertransplantation; (2) interventional treatment,such as transcatheter arterial chemoembolization,portal vein embolization and image-guided locoregional therapies; and (3) molecularly targeted therapies. So far, how to choose the therapeutic modalities remains controversial. Surgeons are faced with the challenge of providing the most appropriate treatment for patients with intermediate-advanced HCC. This review focuses on the optional therapeutic modalities for intermediateadvanced HCC.

  11. Material Voices: Intermediality and Autism (United States)

    Trimingham, Melissa; Shaughnessy, Nicola


    Autism continues to be regarded enigmatically; a community that is difficult to access due to perceived disruptions of interpersonal connectedness. Through detailed observations of two children participating in the Arts and Humanities Research Council funded project "Imagining Autism: Drama, Performance and Intermediality as Interventions for…

  12. Choosing nursing as a career: a qualitative study. (United States)

    Mooney, Mary; Glacken, Michele; O'Brien, Frances


    It is widely accepted that nursing as a career is viewed favourably by society in that it offers job security, mobility and career variety. The main reason for choosing nursing in the 21st century remains the desire to help and care for others, as this paper demonstrates. The findings presented here are part of an on-going longitudinal study which is exploring whether mode of selection into nursing has an impact on a number of variables, of which, career choice is one. The aim of this paper is to identify why non-mature under-graduate students choose nursing as a career and to determine what factors influence this decision. An exploratory-descriptive design, employing a qualitative approach was used. Following receipt of ethical approval, data were collected using focus group interviews and content analysis was employed. Participants were students on a general nursing programme delivered in a large Irish Higher Education Institute. Interviews took place within the first 3 months of the programme, prior to the first clinical placement. It emerged that although nursing was not everybody's first career choice, all participants had sought a career which involved caring. Family or friends in the profession played a role in influencing participants' career selection.

  13. Israelis' perceived motivation for choosing a nursing career. (United States)

    Ben Natan, Merav; Becker, Fainna


    Recruitment problems are one of the main reasons for the shortage of nurses in Israel and elsewhere. The purpose of this study is to clarify factors affecting choice of ideal careers and nursing careers among the general population. A questionnaire constructed by McCabe et al. (2005) was administered to 309 men and women aged 18-50. Data were analyzed by quantitative methods. Research findings indicate that 8% of respondents expressed interest in studying nursing. Significant differences were reported between the choice of ideal and nursing careers. Nursing careers were perceived as lacking interest, challenge, creativity, responsibility, varied wages, high status, comfortable conditions, versus ideal careers. A moderately positive correlation was identified between choice of a nursing career and intrinsic factors affecting this choice. People motivated by desire to help others rather than personal interest or challenges are predisposed to choose a nursing career. Finally, a negative correlation was identified between psychometric scores and choice of a nursing career. The study also identified a positive correlation between both the image of nursing as a profession and the availability of nursing jobs - and the decision to choose a nursing career. This study may facilitate the development of nurse recruitment programs.

  14. Intermediation in Open Development: A Knowledge Stewardship Approach

    Directory of Open Access Journals (Sweden)

    Katherine M. A. Reilly


    Full Text Available Open Development (OD is a subset of ICT4D that studies the potential of IT-enabled openness to support social change among poor or marginalized populations. Early OD work examined the potential of IT-enabled openness to decentralize power and enable public engagement by disintermediating knowledge production and dissemination. However, in practice, intermediaries have emerged to facilitate open data and related knowledge production activities in development processes. We identify five models of intermediation in OD work: decentralized, arterial, ecosystem, bridging, and communities of practice and examine the implications of each for stewardship of open processes. We conclude that studying OD through these five forms of intermediation is a productive way of understanding whether and how different patterns of knowledge stewardship influence development outcomes. We also offer suggestions for future research that can improve our understanding of how to sustain openness, facilitate public engagement, and ensure that intermediation contributes to open development.

  15. Banking on fewer children: financial intermediation, fertility and economic development. (United States)

    Lehr, C S


    This study examines the influence of financial intermediation on fertility rate and labor allocation decisions. A panel Vector Autoregression model using three variables of interest, specifically, financial intermediation, fertility, and industrial employment data in 87 countries, was estimated. This convenient methodology allows the relationship between the variables to change over time. Findings indicate that the increase in wages led some households to shift from traditional labor intensive methods of production to modern sector firms. Since it is optimal for households in the modern sector to have fewer children then the labor allocation decision leads to a lower national fertility. Furthermore, results imply that the emergence and development of the financial intermediation sector will enhance modern sector employment and lower total fertility rates. Thus, the financial intermediation process is an important part of the overall developmental process.

  16. Choosing Whole-Grain Foods: 10 Tips for Purchasing and Storing Whole-Grain Foods (United States)

    ... Newsroom Dietary Guidelines Communicator’s Guide 10 Tips: Choosing Whole-Grain Foods You are here Home 10 Tips: Choosing Whole-Grain Foods Print Share 10 Tips: Choosing Whole-Grain Foods Whole grains are important sources of nutrients ...

  17. 20 CFR 702.403 - Employee's right to choose physician; limitations. (United States)


    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Employee's right to choose physician... PROCEDURE Medical Care and Supervision § 702.403 Employee's right to choose physician; limitations. The employee shall have the right to choose his/her attending physician from among those authorized by...

  18. Reactive intermediates in the gas phase generation and monitoring

    CERN Document Server

    Setser, D W


    Reactive Intermediates in the Gas Phase: Generation and Monitoring covers methods for reactive intermediates in the gas phase. The book discusses the generation and measurement of atom and radical concentrations in flow systems; the high temperature flow tubes, generation and measurement of refractory species; and the electronically excited long-lived states of atoms and diatomic molecules in flow systems. The text also describes the production and detection of reactive species with lasers in static systems; the production of small positive ions in a mass spectrometer; and the discharge-excite

  19. A traditional intermediate moisture meat: Beef cecina. (United States)

    Reyes-Cano, R; Dorantes-Alvarez, L; Hernandez-Sanchez, H; Gutierrez-Lopez, G F


    Cecina is an intermediate moisture meat produced and consumed to a large extent in Mexico. Four samples of cecina coming from different States of this country, were tested for water activity, colour, texture, fat, protein, moisture and chloride content. Sensory and microbiological analyses were also performed. Different fabrication methods for producing cecina were identified, involving large variations in the formulation of the product. There was a significant difference (P < 0·05) among samples regarding fat and chloride content, colour and texture. Differences in colour and saltiness were recorded through sensory analysis. Microbiological analysis showed higher counts than those recommended in the Mexican Official Standard for chopped and raw meat, due to poor sanitary conditions during production and marketing.

  20. [Strategies to choose scaffold materials for tissue engineering]. (United States)

    Gao, Qingdong; Zhu, Xulong; Xiang, Junxi; Lü, Yi; Li, Jianhui


    Current therapies of organ failure or a wide range of tissue defect are often not ideal. Transplantation is the only effective way for long time survival. But it is hard to meet huge patients demands because of donor shortage, immune rejection and other problems. Tissue engineering could be a potential option. Choosing a suitable scaffold material is an essential part of it. According to different sources, tissue engineering scaffold materials could be divided into three types which are natural and its modified materials, artificial and composite ones. The purpose of tissue engineering scaffold is to repair the tissues or organs damage, so could reach the ideal recovery in its function and structure aspect. Therefore, tissue engineering scaffold should even be as close as much to the original tissue or organs in function and structure. We call it "organic scaffold" and this strategy might be the drastic perfect substitute for the tissues or organs in concern. Optimized organization with each kind scaffold materials could make up for biomimetic structure and function of the tissue or organs. Scaffold material surface modification, optimized preparation procedure and cytosine sustained-release microsphere addition should be considered together. This strategy is expected to open new perspectives for tissue engineering. Multidisciplinary approach including material science, molecular biology, and engineering might find the most ideal tissue engineering scaffold. Using the strategy of drawing on each other strength and optimized organization with each kind scaffold material to prepare a multifunctional biomimetic tissue engineering scaffold might be a good method for choosing tissue engineering scaffold materials. Our research group had differentiated bone marrow mesenchymal stem cells into bile canaliculi like cells. We prepared poly(L-lactic acid)/poly(ε-caprolactone) biliary stent. The scaffold's internal played a part in the long-term release of cytokines which

  1. The freedom to choose neutron star magnetic field equilibria

    CERN Document Server

    Glampedakis, Kostas


    Our ability to interpret and glean useful information from the large body of observations of strongly magnetised neutron stars rests largely on our theoretical understanding of magnetic field equilibria. We answer the following question: is one free to arbitrarily prescribe magnetic equilibria such that fluid degrees of freedom can balance the equilibrium equations? We examine this question for various models for neutron star matter; from the simplest single-fluid barotrope to more realistic non-barotropic multifluid models with superfluid/superconducting components, muons and entropy. We do this for both axi- and non-axisymmetric equilibria, and in Newtonian gravity and general relativity. We show that, in axisymmetry, the most realistic model allows complete freedom in choosing a magnetic field equilibrium whereas non-axisymmetric equilibria are never completely arbitrary.

  2. Bedouin Women's Gender Preferences When Choosing Obstetricians and Gynecologists. (United States)

    Amir, Hadar; Abokaf, Hanaa; Levy, Yifat Amir; Azem, Foad; Sheiner, Eyal


    Patients' preferences in choosing obstetricians/gynecologists are widely investigated, but studies among traditional populations are lacking. Bedouins comprise a traditional Arab Muslim society in the Arabian Peninsula (Saudi Arabia), The Levant (Syria, Jordan and Israel) and North Africa (Egypt). Most of the Bedouins in Israel populate several villages, mostly in the southern part of the country. This cross-sectional study compared 200 Bedouin and 200 Jewish women who responded to an anonymous questionnaire. Queried on gender alone, more Bedouin responders preferred female obstetricians/gynecologists (59.5 vs. 33% Jewish responders, p value reputation in 4th place and gender in 5th place. Bedouin women strongly preferred female obstetricians/gynecologists, although professional skills were an important factor in their choice of caregiver. The ideal obstetrician/gynecologist for Bedouin women would be a skilled, knowledgeable, and experienced female.


    Directory of Open Access Journals (Sweden)

    Miglė Eleonora Černikovaitė


    Full Text Available Purpose – Identify medical expectations of tourists choosing Lithuania as medical tourism country and to make comparative analysis with situation in Thailand. Medical tourism is one of the most promising fields of business in the world. International trade in medical services also has huge economic potential and gradually increasing outcome for the global economy (Bookman & Bookman, 2007. Major medical tourism destinations: Thailand, India, Singapore and Malaysia attracted more than 2.5 million medical travellers (United Nations Economic and Social Commission for Asia and the Pacific, 2008. Lithuania is among the major emerging markets in medical tourism that is increasing every year. This study showed that main factors of attracting tourist to Lithuania: fast service and exceptional patient care, the high-tech medical equipment, good prices both for medical and travel services. Comparing to Thailand situation, Lithuania is attractive to the most medical tourist, because of the good quality services with affordable prices and location, while people choosing Thailand – mainly is affected by advertising. The main recommendation for attracting medical tourists to Lithuania is to initiate the advertising campaign to the targeted audiences. Design/methodology/approach – The comparative analysis of scientific literature and empirical comparative quantitative research was executed for acquiring the expectations for medical tourists in Lithuania. Findings – Overview of health and medical tourism situation in Lithuania and other emerging markets. This study showed that main factors of attracting tourist to Lithuania: fast service and exceptional patient care, the high-tech medical equipment, good prices both for medical and travel services and other. Comparative empirical analysis of medical tourist expectations in Lithuania and Thailand. Comparing to Thailand situation, Lithuania is attractive to the most medical tourist, because of the good

  4. Bending the law and crossing borders choosing Danish sperm

    DEFF Research Database (Denmark)

    Willum Adrian, Stine

    In recent years, Denmark has become a European destination for couples and single women wanting sperm donation. One reason is that the current regulation is liberal in the sense that it enables single women and lesbians to be treated. Since neither private sperm banks nor clinics run by midwifes...... have to apply to the law, it is even possible to choose between anonymous and non-anonymous donors. In this presentation, I focus on how the fertility travellers seeking sperm donation in Denmark, and the employees at Danish fertility clinics and sperm banks, negotiate the ethical implications of using...... sperm donation. Inspired by Karen Barad’s theory agential realism, I will analyze how ethics is material-discoursively negotiated in practice. The presentation is based on an ethnographic fieldwork carried out at fertility clinics in Denmark. It includes observations from the clinics, and interviews...

  5. Choosing a coverage probability for forecasting the incidence of cancer. (United States)

    Young, Derek S; Mills, Terence M


    Loddon Mallee Integrated Cancer Service plays a key role in planning the delivery of cancer services in the Loddon Mallee Region of Victoria, Australia. Such planning relies on the accuracy of forecasting the incidence of cancer. Perhaps more importantly is the need to reflect the uncertainty of these forecasts, which is usually carried out through prediction intervals. Standard confidence levels (e.g., 90% or 95%) are typically employed when forecasting the incidence of cancer, but decision-theoretic approaches are available to help choose an optimal coverage probability by minimizing the combined risk of the interval width and noncoverage of the interval. We proceed with the decision-theoretic framework and discuss some general strategies for defining candidate loss functions for forecasting the incidence of cancer, such as the data we analyze for the Loddon Mallee Region.

  6. Choosing a language in international office service encounters

    DEFF Research Database (Denmark)

    Hazel, Spencer

    Choosing a language in international office service encounters – from multilingual miscellany to medium-of-interaction in a matter of seconds Spencer Hazel Roskilde University, Denmark In higher education settings characterized by increasing transnational student and staff mobility, members...... Preisler (eds.) Language alternation, language choice and language encounter in international education. Dordrecht: Springer Preisler, Bent, Ida Klitgård, and Anne H. Fabricius. (2011). Language and learning in the international university: from English uniformity to diversity and hybridity. Bristol...... are required to navigate dynamically fluctuating participation frameworks and their contingent language scenarios. Although some interactional settings have institutionally implemented rules or norms relating to which language is the designated medium-of-interaction, this is not the case across all settings...

  7. Larval helminths in intermediate hosts

    DEFF Research Database (Denmark)

    Fredensborg, Brian Lund; Poulin, R


    Density-dependent effects on parasite fitness have been documented from adult helminths in their definitive hosts. There have, however, been no studies on the cost of sharing an intermediate host with other parasites in terms of reduced adult parasite fecundity. Even if larval parasites suffer...... a reduction in size, caused by crowding, virtually nothing is known about longer-lasting effects after transmission to the definitive host. This study is the first to use in vitro cultivation with feeding of adult trematodes to investigate how numbers of parasites in the intermediate host affect the size...... and fecundity of adult parasites. For this purpose, we examined two different infracommunities of parasites in crustacean hosts. Firstly, we used experimental infections of Maritrema novaezealandensis in the amphipod, Paracalliope novizealandiae, to investigate potential density-dependent effects in single...

  8. Choosing the best heuristic for seeded alignment of DNA sequences

    Directory of Open Access Journals (Sweden)

    Buhler Jeremy


    Full Text Available Abstract Background Seeded alignment is an important component of algorithms for fast, large-scale DNA similarity search. A good seed matching heuristic can reduce the execution time of genomic-scale sequence comparison without degrading sensitivity. Recently, many types of seed have been proposed to improve on the performance of traditional contiguous seeds as used in, e.g., NCBI BLASTN. Choosing among these seed types, particularly those that use information besides the presence or absence of matching residue pairs, requires practical guidance based on a rigorous comparison, including assessment of sensitivity, specificity, and computational efficiency. This work performs such a comparison, focusing on alignments in DNA outside widely studied coding regions. Results We compare seeds of several types, including those allowing transition mutations rather than matches at fixed positions, those allowing transitions at arbitrary positions ("BLASTZ" seeds, and those using a more general scoring matrix. For each seed type, we use an extended version of our Mandala seed design software to choose seeds with optimized sensitivity for various levels of specificity. Our results show that, on a test set biased toward alignments of noncoding DNA, transition information significantly improves seed performance, while finer distinctions between different types of mismatches do not. BLASTZ seeds perform especially well. These results depend on properties of our test set that are not shared by EST-based test sets with a strong bias toward coding DNA. Conclusion Practical seed design requires careful attention to the properties of the alignments being sought. For noncoding DNA sequences, seeds that use transition information, especially BLASTZ-style seeds, are particularly useful. The Mandala seed design software can be found at

  9. Heterologous expression of membrane proteins: choosing the appropriate host.

    Directory of Open Access Journals (Sweden)

    Florent Bernaudat

    Full Text Available BACKGROUND: Membrane proteins are the targets of 50% of drugs, although they only represent 1% of total cellular proteins. The first major bottleneck on the route to their functional and structural characterisation is their overexpression; and simply choosing the right system can involve many months of trial and error. This work is intended as a guide to where to start when faced with heterologous expression of a membrane protein. METHODOLOGY/PRINCIPAL FINDINGS: The expression of 20 membrane proteins, both peripheral and integral, in three prokaryotic (E. coli, L. lactis, R. sphaeroides and three eukaryotic (A. thaliana, N. benthamiana, Sf9 insect cells hosts was tested. The proteins tested were of various origins (bacteria, plants and mammals, functions (transporters, receptors, enzymes and topologies (between 0 and 13 transmembrane segments. The Gateway system was used to clone all 20 genes into appropriate vectors for the hosts to be tested. Culture conditions were optimised for each host, and specific strategies were tested, such as the use of Mistic fusions in E. coli. 17 of the 20 proteins were produced at adequate yields for functional and, in some cases, structural studies. We have formulated general recommendations to assist with choosing an appropriate system based on our observations of protein behaviour in the different hosts. CONCLUSIONS/SIGNIFICANCE: Most of the methods presented here can be quite easily implemented in other laboratories. The results highlight certain factors that should be considered when selecting an expression host. The decision aide provided should help both newcomers and old-hands to select the best system for their favourite membrane protein.

  10. Branching of keratin intermediate filaments. (United States)

    Nafeey, Soufi; Martin, Ines; Felder, Tatiana; Walther, Paul; Felder, Edward


    Keratin intermediate filaments (IFs) are crucial to maintain mechanical stability in epithelial cells. Since little is known about the network architecture that provides this stiffness and especially about branching properties of filaments, we addressed this question with different electron microscopic (EM) methods. Using EM tomography of high pressure frozen keratinocytes, we investigated the course of several filaments in a branching of a filament bundle. Moreover we found several putative bifurcations in individual filaments. To verify our observation we also visualized the keratin network in detergent extracted keratinocytes with scanning EM. Here bifurcations of individual filaments could unambiguously be identified additionally to bundle branchings. Interestingly, identical filament bifurcations were also found in purified keratin 8/18 filaments expressed in Escherichia coli which were reassembled in vitro. This excludes that an accessory protein contributes to the branch formation. Measurements of the filament cross sectional areas showed various ratios between the three bifurcation arms. This demonstrates that intermediate filament furcation is very different from actin furcation where an entire new filament is attached to an existing filament. Instead, the architecture of intermediate filament bifurcations is less predetermined and hence consistent with the general concept of IF formation.

  11. Consumer Decision-Making Based on Review Websites: Are There Differences Between Choosing a Hotel and Choosing a Physician? (United States)

    Germeni, Evi; Schulz, Peter J


    Background Web users are increasingly encouraged to rate and review consumer services (eg, hotels, restaurants) and, more recently, this is also the case for physicians and medical services. The resemblance in the setup and design of commercial rating websites (CRWs) and Web-based physician rating websites (PRWs) raises the question of whether choice-making processes based on the two types of websites could also be similar. Objective This qualitative study sought to explore the extent to which consumer decision making based on Web-based reviews is the same for consumer services (ie, choice of a hotel) and health services (ie, choice of a pediatrician), while providing an in-depth understanding of potential differences or similarities. Methods Between June and August 2015, we carried out a total of 22 qualitative interviews with young parents residing in the German-speaking part of Switzerland. Participants were invited to complete 2 choice tasks, which involved (1) choosing a hotel based on the commercial Web-based rating website TripAdvisor and (2) selecting a pediatrician based on the PRW Jameda. To better understand consumers’ thought processes, we instructed participants to “think aloud”, namely to verbalize their thinking while sorting through information and reaching decisions. Using a semistructured interview guide, we subsequently posed open-ended questions to allow them to elaborate more on factors influencing their decision making, level of confidence in their final choice, and perceived differences and similarities in their search for a hotel and a physician. All interviews were recorded, transcribed, and analyzed using an inductive thematic approach. Results Participants spent on average 9:57 minutes (standard deviation=9:22, minimum=3:46, maximum=22:25) searching for a hotel and 6:17 minutes (standard deviation=4:47, minimum=00:38, maximum=19:25) searching for a pediatrician. Although the choice of a pediatrician was perceived as more important

  12. Role of Intermediate Filaments in Vesicular Traffic

    Directory of Open Access Journals (Sweden)

    Azzurra Margiotta


    Full Text Available Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway.

  13. Intermedial Strategies of Memory in Contemporary Novels

    DEFF Research Database (Denmark)

    Tanderup, Sara


    In her article "Intermedial Strategies and Memory in Contemporary Novels" Sara Tanderup discusses a tendency in contemporary literature towards combining intermedial experiments with a thematic preoccupation with memory and trauma. Analyzing selected works by Steven Hall, Jonathan Safran Foer...

  14. An Overview of the The Intermediate Palomar Transient Factory Surveys (United States)

    Bellm, Eric Christopher; Kulkarni, Shrinivas R.; Intermediate Palomar Transient Factory Collaboration


    The Intermediate Palomar Transient Factory (iPTF) has conducted a range of time-domain surveys since 2013. As iPTF concludes, I will review the these goals of surveys, their on-sky performance, and implications for next-generation surveys such as the Zwicky Transient Facility and LSST. Finally, I will describe the public data products being released.

  15. Intermediate Filaments in Caenorhabditis elegans. (United States)

    Zuela, Noam; Gruenbaum, Yosef


    More than 70 different genes in humans and 12 different genes in Caenorhabditis elegans encode the superfamily of intermediate filament (IF) proteins. In C. elegans, similar to humans, these proteins are expressed in a cell- and tissue-specific manner, can assemble into heteropolymers and into 5-10nm wide filaments that account for the principal structural elements at the nuclear periphery, nucleoplasm, and cytoplasm. At least 5 of the 11 cytoplasmic IFs, as well as the nuclear IF, lamin, are essential. In this chapter, we will include a short review of our current knowledge of both cytoplasmic and nuclear IFs in C. elegans and will describe techniques used for their analyses.

  16. ESL intermediate/advanced writing

    CERN Document Server

    Munoz Page, Mary Ellen; Jaskiewicz, Mary


    Master ESL (English as a Second Language) Writing with the study guide designed for non-native speakers of English. Skill-building lessons relevant to today's topics help ESL students write complete sentences, paragraphs, and even multi-paragraph essays. It's perfect for classroom use or self-guided writing preparation.DETAILS- Intermediate drills for improving skills with parallel structure, mood, correct shifting errors & dangling participles- Advanced essay drills focusing on narrative, descriptive, process, reaction, comparison and contrast- Superb preparation for students taking the TOEFL

  17. Intermediate thinnings as a source of energywood

    Energy Technology Data Exchange (ETDEWEB)

    Sammallahti, K.; Laespae, O.; Nurmi, J. (Finnish Forest Research Inst., Kannus (Finland)), e-mail:, e-mail:, e-mail:


    During 2008 and 2009 10 hectares of spruce stand was harvested with an energy wood method and 3,8 hectares with a conventional method. Average DBH was 21 cm, length 19 m and the number of stems per hectare was 674. The harvester productivity was in this study 10 % higher with the conventional method (36,2 m3 / ha) than with the energy wood method (32,6 m3 / ha). The second part of the study consisted baling with a Timberjack 1490D residue baler on an intermediate thinning. In 2008 residues were baled from a total area of 8,7 hectares. Total yield was 218 bales and yield per hectare was 26 bales. Yield per hour was 19,7 bales and the average time consumption per bale was 3,18 minutes. (orig.)

  18. 34 CFR 200.17 - Intermediate goals. (United States)


    ... 34 Education 1 2010-07-01 2010-07-01 false Intermediate goals. 200.17 Section 200.17 Education... Programs Operated by Local Educational Agencies Adequate Yearly Progress (ayp) § 200.17 Intermediate goals. Each State must establish intermediate goals that increase in equal increments over the period...

  19. Time to choose – DSM-5, ICD-11 or both?

    Directory of Open Access Journals (Sweden)

    Tyrer, Peter


    Full Text Available DSM-5 was published in May 2013, and ICD 11 is not due to be published until the end of 2015 at the earliest. Nevertheless, it is possible to make a comparison at this early stage as much of the main decisions have been made with both classifications. DSM-5 aimed to make a paradigm shift by providing objective, independent measures of classification, but in this respect it clearly failed. It did respond to previous criticisms that there were too many diagnoses in the classification and that eliminated some conditions in favour of larger groupings (eg, autism spectrum disorder, but it has still come in for heavy criticism. ICD 11 deviates from DSM-5 in radically different classifications of personality and stress disorders and in general has pursued a different pathway, concentrating on clinical utility as the main guide to the classification. It is up to practitioners to choose which they prefer, but ICD 11 will be in a much stronger position than ICD 10 was when it was published in 1999.

  20. Tissue regeneration during tissue expansion and choosing an expander

    Directory of Open Access Journals (Sweden)

    K Agrawal


    Full Text Available This paper reviews the various aspects of tissue regeneration during the process of tissue expansion. "Creep" and mechanical and biological "stretch" are responsible for expansion. During expansion, the epidermis thickens, the dermis thins out, vascularity improves, significant angiogenesis occurs, hair telogen phase becomes shorter and the peripheral nerves, vessels and muscle fibres lengthen. Expansion is associated with molecular changes in the tissue. Almost all these biological changes are reversible after the removal of the expander.This study is also aimed at reviewing the difficulty in deciding the volume and dimension of the expander for a defect. Basic mathematical formulae and the computer programmes for calculating the dimension of tissue expanders, although available in the literature, are not popular. A user-friendly computer programme based on the easily available Microsoft Excel spread sheet has been introduced. When we feed the area of defect and base dimension of the donor area or tissue expander, this programme calculates the volume and height of the expander. The shape of the expander is decided clinically based on the availability of the donor area and the designing of the future tissue movement. Today, tissue expansion is better understood biologically and mechanically. Clinical judgement remains indispensable in choosing the size and shape of the tissue expander.

  1. Choosing amine-based absorbents for CO2 capture. (United States)

    Gomes, João; Santos, Samuel; Bordado, João


    CO2 capture from gaseous effluents is one of the great challenges faced by chemical and environmental engineers, as the increase in CO2 levels in the Earth atmosphere might be responsible for dramatic climate changes. From the existing capture technologies, the only proven and mature technology is chemical absorption using aqueous amine solutions. However, bearing in mind that this process is somewhat expensive, it is important to choose the most efficient and, at the same time, the least expensive solvents. For this purpose, a pilot test facility was assembled and includes an absorption column, as well as a stripping column, a heat exchanger between the two columns, a reboiler for the stripping column, pumping systems, surge tanks and all necessary instrumentation and control systems. Some different aquous amine solutions were tested on this facility and it was found that, from a set of six tested amines, diethanol amine is the one that turned out to be the most economical choice, as it showed a higher CO2 loading capacity (0.982 mol of CO2 per mol of amine) and the lowest price per litre (25.70 €/L), even when compared with monoethanolamine, the benchmark solvent, exhibiting a price per litre of 30.50 €/L.

  2. When I cut, you choose method implies intransitivity (United States)

    Makowski, Marcin; Piotrowski, Edward W.


    There is a common belief that humans and many animals follow transitive inference (choosing A over C on the basis of knowing that A is better than B and B is better than C). Transitivity seems to be the essence of rational choice. We present a theoretical model of a repeated game in which the players make a choice between three goods (e.g. food). The rules of the game refer to the simple procedure of fair division among two players, known as the “I cut, you choose” mechanism which has been widely discussed in the literature. In this game one of the players has to make intransitive choices in order to achieve the optimal result (for him/her and his/her co-player). The point is that an intransitive choice can be rational. Previously, an increase in the significance of intransitive strategies was achieved by referring to models of quantum games. We show that relevant intransitive strategies also appear in the classic description of decision algorithms.

  3. Covalent functionalization of graphene with reactive intermediates. (United States)

    Park, Jaehyeung; Yan, Mingdi


    Graphene, a material made exclusively of sp(2) carbon atoms with its π electrons delocalized over the entire 2D network, is somewhat chemically inert. Covalent functionalization can enhance graphene's properties including opening its band gap, tuning conductivity, and improving solubility and stability. Covalent functionalization of pristine graphene typically requires reactive species that can form covalent adducts with the sp(2) carbon structures in graphene. In this Account, we describe graphene functionalization reactions using reactive intermediates of radicals, nitrenes, carbenes, and arynes. These reactive species covalently modify graphene through free radical addition, CH insertion, or cycloaddition reactions. Free radical additions are among the most common reaction, and these radicals can be generated from diazonium salts and benzoyl peroxide. Electron transfer from graphene to aryl diazonium ion or photoactivation of benzoyl peroxide yields aryl radicals that subsequently add to graphene to form covalent adducts. Nitrenes, electron-deficient species generated by thermal or photochemical activation of organic azides, can functionalize graphene very efficiently. Because perfluorophenyl nitrenes show enhanced bimolecular reactions compared with alkyl or phenyl nitrenes, perfluorophenyl azides are especially effective. Carbenes are used less frequently than nitrenes, but they undergo CH insertion and C═C cycloaddition reactions with graphene. In addition, arynes can serve as a dienophile in a Diels-Alder type reaction with graphene. Further study is needed to understand and exploit the chemistry of graphene. The generation of highly reactive intermediates in these reactions leads to side products that complicate the product composition and analysis. Fundamental questions remain about the reactivity and regioselectivity of graphene. The differences in the basal plane and the undercoordinated edges of graphene and the zigzag versus arm-chair configurations

  4. 技术差距、外资来源与工业全要素生产率--基于中间品三维框架的分析%Technology Gap,Foreign Capital Source and Total Factor Productivity of Industry---Analysis of 3 D Frame Based on Intermediate Goods

    Institute of Scientific and Technical Information of China (English)



    利用2008~2014年间两位码分类的中国工业分布滞后面板数据,在中间品三维框架下估计了中国工业技术差距对工业全要素生产率的效应。结果表明:随着中间品使用效率快速提升、生产成本日益减小和创新能力的逐渐强化,美欧日韩FDI对工业全要素生产率改善的贡献度越来越大,而我国港澳台地区FDI对工业全要素生产率改善的贡献呈递减之势。只有积极制定和实施以低效率外资退出为主要内容的差异化引资战略,善于利用外资的退出效应释放新的制度红利,才是提升中国工业国际竞争力的根本保证。%Using China industry distributed lag panel data with two-code classified from 2008 to 2014,the paper studies the effects that China industrial technology gap makes to industry total factor productivity in 3D frame based on intermediate goods. Result finds out that with the quick improvement of intermediate goods using efficiency,the gradual reduction of in-termediate goods production cost and the gradual strengthen of intermediate product innovation ability,FDI of America,Eu-rope,Japan and South Korea makes more contribution on the improvement of industry performance,but FDI of Hong Kong, Macao and Taiwan makes less contribution. The paper's conclusion has profound policy meaning:only through takes the withdrawal of low efficiency foreign capital as its main content,and being good at obtaining new institutional dividend from the withdrawal effect of foreign capital,is ultimately guarantee of enhancing China industry international competition.

  5. Intermediate Mass Fragments Emission in Peripheral Heavy-Ion Collisions (United States)

    Bini, M.; Casini, G.; Maurenzig, P. R.; Olmi, A.; Pasquali, G.; Piantelli, S.; Poggi, G.; Stefanini, A. A.; Taccetti, N.

    The collision 116Sn + 93Nb at 29.5 AMeV in direct and reverse kinematics has been studied at LNS in Catania. In particular the emission pattern in the νperp - νpar plane of Intermediate Mass Fragments with Z=3-7 (IMF's) shows that for peripheral reactions most of IMF's are emitted at velocities intermediate between those of the projectile- and target-like products. From coulomb trajectory calculations one can infere that these IMF's are produced mainly in the interaction zone, in a short time interval at the end of the target-projectile interaction.

  6. Intermediate view synthesis from stereoscopic images

    Institute of Scientific and Technical Information of China (English)

    Lü Chaohui; An Ping; Zhang Zhaoyang


    A new method is proposed for synthesizing intermediate views from a pair of stereoscopic images. In order to synthesize high-quality intermediate views, the block matching method together with a simplified multi-window technique and dynamic programming is used in the process of disparity estimation. Then occlusion detection is performed to locate occluded regions and their disparities are compensated. After the projecton of the left-to-right and right-to-left disparities onto the intermediate image, intermediate view is synthesized considering occluded regions. Experimental results show that our synthesis method can obtain intermediate views with higher quality.

  7. How Do We Choose among Strategies to Accomplish Cognitive Tasks? Evidence from Behavioral and Event-Related Potential Data in Arithmetic Problem Solving (United States)

    Taillan, Julien; Dufau, Stéphane; Lemaire, Patrick


    We used event-related potentials (ERPs) to determine the time course of mechanisms underlying strategy selection. Participants had to select the better strategy on multiplication problems (i.e., 51 × 27) to find approximate products. They could choose between rounding up and rounding down both operands to their nearest decades. Two types of…

  8. Perspective: Spectroscopy and kinetics of small gaseous Criegee intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yuan-Pern, E-mail: [Department of Applied Chemistry and Institute of Molecular Science, National Chiao Tung University, Hsinchu 30010, Taiwan and Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan (China)


    The Criegee intermediates, carbonyl oxides proposed by Criegee in 1949 as key intermediates in the ozonolysis of alkenes, play important roles in many aspects of atmospheric chemistry. Because direct detection of these gaseous intermediates was unavailable until recently, previous understanding of their reactions, derived from indirect experimental evidence, had great uncertainties. Recent laboratory detection of the simplest Criegee intermediate CH{sub 2}OO and some larger members, produced from ultraviolet irradiation of corresponding diiodoalkanes in O{sub 2}, with various methods such as photoionization, ultraviolet absorption, infrared absorption, and microwave spectroscopy opens a new door to improved understanding of the roles of these Criegee intermediates. Their structures and spectral parameters have been characterized; their significant zwitterionic nature is hence confirmed. CH{sub 2}OO, along with other products, has also been detected directly with microwave spectroscopy in gaseous ozonolysis reactions of ethene. The detailed kinetics of the source reaction, CH{sub 2}I + O{sub 2}, which is critical to laboratory studies of CH{sub 2}OO, are now understood satisfactorily. The kinetic investigations using direct detection identified some important atmospheric reactions, including reactions with NO{sub 2}, SO{sub 2}, water dimer, carboxylic acids, and carbonyl compounds. Efforts toward the characterization of larger Criegee intermediates and the investigation of related reactions are in progress. Some reactions of CH{sub 3}CHOO are found to depend on conformation. This perspective examines progress toward the direct spectral characterization of Criegee intermediates and investigations of the associated reaction kinetics, and indicates some unresolved problems and prospective challenges for this exciting field of research.

  9. Best Practices and Processes for Choosing Research Priorities (United States)

    Briscoe, M. G.


    Individuals, teams, departments, organizations, funding agencies, committees, and others all need to select desirable research priorities from many possible alternatives. One cannot do everything, one cannot afford everything, so what to select? Essays and reports since Weinberg (1963) have suggested criteria for choosing science topics. Popper et al (2000) reviewed and summarized all that had gone before in the subject of setting priorities; their main conclusions were that the underlying principles were the promotion of excellence and relevance. Sea Change (2015) from the NRC/OSB focused on four criteria. From most important to least important, they were transformative science, societal impacts, readiness, and partnership potential; these four criteria embodied the essence of the suggestions from Weinberg on, framed with the pragmatism of ORPISS (2007). Getting to the final set of priorities from many candidates involves a sequence of formal or informal processes, only the last of which is the application of the selected, weighted criteria. As developed by professional prioritization experts, the best-practice steps and processes are: Collection of input candidates from the community. Clustering and parsing/rephrasing of the input to eliminate redundancy and repetition and develop statements at a useful level of specificity. (NOTE:there is no counting of input to see how many times a particular topic was mentioned. The goal is diversity in the input, not a popularity contest.) Development of the selection criteria, and weighting the chosen criteria. Application of the selection criteria to the clustered/adjusted candidates. Finally, two more best practices: Do continuing sanity checks, to avoid losing sight of the goals of the effort. Resist the temptation to just sit around a table and talk about it to arrive at the priorities, which depends too much on who the specific members of the prioritization team are, and provides no transparency or explanation of why

  10. Personal values Involved in choosing a College: Analysis Using the Means-End Chain Approach

    Directory of Open Access Journals (Sweden)

    Lílian Carolina Viana


    Full Text Available The investigation the reasons for choice of products and services by consumers stands out as relevant in the area of ​​market studies, as well as notes management for any organization. Through the Theory of Means-End Chain proposed by Gutman (1982, which relates the “means” (attributes and benefits linked to the consumption of products or services with the “ends” in terms of personal values achieved, it is possible understand of the meanings that consumers attribute the choice of products and services in a more abstract level. Thus, the objective of this study is to understand what aspects, considering attributes, consequences and personal values ​​guide the behavior of students in choosing the nursing course at a private institution of higher education. Based on the theory mentioned it was adopted the technique laddering, in-depth interview and analysis methodology and representation of the hierarchical value map, which was interpreted and analyzed in order to understand the cognitive structure of students’ choice.The analysis of the results indicate that students are guided primarily by hedonistic values of happiness itself the choice of nursing in college studied.

  11. Intermediate inflation from rainbow gravity

    CERN Document Server

    Barrow, John D


    It is possible to dualize theories based on deformed dispersion relations and Einstein gravity so as to map them into theories with trivial dispersion relations and rainbow gravity. This often leads to "dual inflation" without the usual breaking of the strong energy condition. We identify the dispersion relations in the original frame which map into "intermediate" inflationary models. These turn out to be particularly simple: power-laws modulated by powers of a logarithm. The fluctuations predicted by these scenarios are near, but not exactly scale-invariant, with a red running spectral index. These dispersion relations deserve further study within the context of quantum gravity and the phenomenon of dimensional reduction in the ultraviolet.

  12. Intermediate Jacobians of moduli spaces

    CERN Document Server

    Arapura, D; Arapura, Donu; Sastry, Pramathanath


    Let $SU_X(n,L)$ be the moduli space of rank n semistable vector bundles with fixed determinant L on a smooth projective genus g curve X. Let $SU_X^s(n,L)$ denote the open subset parametrizing stable bundles. We show that if g>3 and n > 1, then the mixed Hodge structure on $H^3(SU_X^s(n, L))$ is pure of type ${(1,2),(2,1)}$ and it carries a natural polarization such that the associated polarized intermediate Jacobian is isomorphic J(X). This is new when deg L and n are not coprime. As a corollary, we obtain a Torelli theorem that says roughly that $SU_X^s(n,L)$ (or $SU_X(n,L)$) determines X. This complements or refines earlier results of Balaji, Kouvidakis-Pantev, Mumford-Newstead, Narasimhan-Ramanan, and Tyurin.

  13. “Fabrics China”:the Right Way to Choose

    Institute of Scientific and Technical Information of China (English)


    Facing so many fabric suppliers and products,for fashion brands,how to make a choice;meanwhile,several suppliers are searching for their Mr.Right to do the deal.Is there any shortcut?"Fabrics China-New Products Promotion Fair"is the

  14. Elements of banking intermediation in the Algerian Banking system and the means to activate it

    Directory of Open Access Journals (Sweden)

    Habbar Abderezak, Dr.


    Banking intermediation raises several interrelated issues for banks, the central bank and the Treasury. It is linked to the gross domestic product, money supply and bank liquidity, etc. These elements will be examined in this article to learn the elements of bank intermediation in the Algerian banking system and ways of strengthening it.

  15. Crystal structures of deoxygenation products and the characteristics of reactions of phenyl- (trihalomethyl)mercury with tetraphenylcyclone

    Institute of Scientific and Technical Information of China (English)


    The single crystal structures of the gem-dihalides (3a and 3b)produced from the reactions of tetraphenylcy- clone (TPCP) with phenyl(trihalomethyl)mercury (trihalo = tribromo, bromodichloro) are reported. The structural parameters of the X-ray single crystal analysis vary slightly with the radius of the halogen atom in dihalides and are found to be related to the yields of the deoxygenation products. These results support the proposed mechanism for the carbene reaction of this type and reflect the key role of the structural characteristics of the incipient carbonyl ylide intermediate in choosing different competitive reaction path- ways.

  16. A New Vaccinia Virus Intermediate Transcription Factor


    Sanz, Patrick; Moss, Bernard


    Transcription of the vaccinia virus genome is mediated by a virus-encoded multisubunit DNA-dependent RNA polymerase in conjunction with early-, intermediate-, and late-stage-specific factors. Previous studies indicated that two virus-encoded proteins (capping enzyme and VITF-1) and one unidentified cellular protein (VITF-2) are required for specific transcription of an intermediate promoter template in vitro. We have now extensively purified an additional virus-induced intermediate transcript...

  17. Experiments in intermediate energy physics

    Energy Technology Data Exchange (ETDEWEB)

    Dehnhard, D.


    Research in experimental nuclear physics was done from 1979 to 2002 primarily at intermediate energy facilities that provide pion, proton, and kaon beams. Particularly successful has been the work at the Los Alamos Meson Physics Facility (LAMPF) on unraveling the neutron and proton contributions to nuclear ground state and transition densities. This work was done on a wide variety of nuclei and with great detail on the carbon, oxygen, and helium isotopes. Some of the investigations involved the use of polarized targets which allowed the extraction of information on the spin-dependent part of the triangle-nucleon interaction. At the Indiana University Cyclotron Facility (IUCF) we studied proton-induced charge exchange reactions with results of importance to astrophysics and the nuclear few-body problem. During the first few years, the analysis of heavy-ion nucleus scattering data that had been taken prior to 1979 was completed. During the last few years we created hypernuclei by use of a kaon beam at Brookhaven National Laboratory (BNL) and an electron beam at Jefferson Laboratory (JLab). The data taken at BNL for a study of the non-mesonic weak decay of the A particle in a nucleus are still under analysis by our collaborators. The work at JLab resulted in the best resolution hypernuclear spectra measured thus far with magnetic spectrometers.

  18. Composição químico-bromatológica de variedades de cana-de-açúcar (Saccharum spp L. com diferentes ciclos de produção (precoce e intermediário em três idades de corte Chemical composition of sugar cane varieties (Saccharum spp L. with different cycles of production in three cut time

    Directory of Open Access Journals (Sweden)

    Alberto Magno Fernandes


    composition, the potentialy degradable fraction of NDF (B2 and undegradable fraction (C and to estimate the ruminal fill of sugar cane with different cycles of production (early and intermediate, in three cut times (426, 487 and 549 days. The laboratorial analysis consisted in dry matter (DM, organic matter, ash, crude protein (CP, ether extract, lignin, neutral detergent fiber (NDF, neutral detergent fiber corrected for ash and protein, acid detergent fiber (ADF, neutral detergent insoluble protein, acid detergent insoluble protein and neutral detergent protein soluble. The TDN was calculated by chemical composition. The degradable and undegradable fractions, and fiber digestion rate, as well as the ruminal fill were estimated by kinetic parameters obtained throught in situ incubation. The advanced cut time increased the DM in 9.5%. The intermediate varieties presented higher TDN than early varieties, which had the highest contents of NDF and ADF, whose respective values were 487.56 and 471.03, and 287.87 and 247,54 g/kg DM for the early and intermediate varieties, respectively. The TDN increased linearly with the cut time, varying from 62.45 to 63.50%; however the NDF and ADF contents presented quadratic behavior. The early varieties presented higher content of CP than the intermediate only in the cut time of 549 days; contrarily, the brix of the sugar cane was superior to the intermediate varieties in the last cut. The early varieties presented larger total ruminal fill and lower fiber digestion rate. The degradable fraction of the fiber was reduced and the undegradable fraction was linearly increased with the age of the plants.

  19. Choosing War: The Decision to Invade Iraq and Its Aftermath (United States)


    usA Managing Editor GeorGe C. MAerz Supervisory Editor lIsA M. yAMbrICk Writer-Editor CAlvIn b. kelley Writer-Editor MArTIn J. PeTers Production...ignored bible on political-military planning for complex contingencies, Presidential Decision Directive 56, was headed in the right direction. Early...hensTrAnD, usA Managing Editor GeorGe C. MAerz Supervisory Editor lIsA M. yAMbrICk Writer-Editor CAlvIn b. kelley Writer-Editor MArTIn J. PeTers Production

  20. Choosing and using disposable body-worn continence pads. (United States)

    Gilbert, Rachel

    Disposable, body-worn pads are the product most commonly chosen to contain and absorb urine and faeces (Pomfret, 2000). The cost to the NHS of supplying continence pads has been estimated at 80 million pounds per annum (Euromonitor, 1999) and is a huge financial burden on local services.

  1. Upward and downward comparison in the intermediate-status group: the role of social stratification stability. (United States)

    Caricati, Luca


    This work analyses intergroup comparison choices made by intermediate-status group members. Seventy-six psychology students were categorized in an intermediate position with respect to other faculties. Stability was manipulated at three levels: stable, upwardly unstable, and downwardly unstable. Data on strength of comparison, comparison for enhancing, comparison for evaluation, and ingroup identification were collected. Results revealed that in the stable condition, participants were equally engaged in both upward and downward comparison. In the upwardly unstable condition, participants were more likely to compare themselves with the high-status group, whereas in the downwardly unstable condition, they were more likely to choose a downward comparison. In this latter condition, both downward comparison for enhancement and in-group identification were lower than in other conditions.

  2. Intermediate Energy Nuclear Physics Program

    Energy Technology Data Exchange (ETDEWEB)

    Dunne, James, A.


    The originally proposed and funded research activities followed two major areas of study: semileptonic probes of the hadronic neutral current and charm production. The charm production work revolved around the Jefferson Lab experiment E03-008, 'Sub-threshold J/psi Photoprouction', which ran in late 2004. The PI was a co-spokesperson for the experiment. For the three year renewal proposal starting in 2007, the scope and size of the research project changed and increased. In addition to the parity violating studies, the PI had well defined lead roles in a series experiments nucleon spin-structure functions.

  3. Air Conditioning. Performance Objectives. Intermediate Course. (United States)

    Long, William

    Several intermediate performance objectives and corresponding criterion measures are listed for each of seven terminal objectives for an intermediate air conditioning course. The titles of the seven terminal objectives are Refrigeration Cycle, Job Requirement Skills, Air Conditioning, Trouble Shooting, Performance Test, Shop Management, and S.I.E.…

  4. Some Intermediate-Level Violin Concertos. (United States)

    Abramson, Michael


    Contends that many violin students attempt difficult concertos before they are technically or musically prepared. Identifies a variety of concertos at the intermediate and advanced intermediate-level for students to study and master before attempting the advanced works by Bach and Mozart. Includes concertos by Vivaldi, Leclair, Viotti, Haydn,…

  5. 19 CFR 122.84 - Intermediate airport. (United States)


    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Intermediate airport. 122.84 Section 122.84... Intermediate airport. (a) Application. The provisions of this section apply at any U.S. airport to which an... aircraft arrives at the next airport, the aircraft commander or agent shall make entry by filing the:...

  6. The complex task of choosing a de novo assembly: lessons from fungal genomes. (United States)

    Gallo, Juan Esteban; Muñoz, José Fernando; Misas, Elizabeth; McEwen, Juan Guillermo; Clay, Oliver Keatinge


    Selecting the values of parameters used by de novo genomic assembly programs, or choosing an optimal de novo assembly from several runs obtained with different parameters or programs, are tasks that can require complex decision-making. A key parameter that must be supplied to typical next generation sequencing (NGS) assemblers is the k-mer length, i.e., the word size that determines which de Bruijn graph the program should map out and use. The topic of assembly selection criteria was recently revisited in the Assemblathon 2 study (Bradnam et al., 2013). Although no clear message was delivered with regard to optimal k-mer lengths, it was shown with examples that it is sometimes important to decide if one is most interested in optimizing the sequences of protein-coding genes (the gene space) or in optimizing the whole genome sequence including the intergenic DNA, as what is best for one criterion may not be best for the other. In the present study, our aim was to better understand how the assembly of unicellular fungi (which are typically intermediate in size and complexity between prokaryotes and metazoan eukaryotes) can change as one varies the k-mer values over a wide range. We used two different de novo assembly programs (SOAPdenovo2 and ABySS), and simple assembly metrics that also focused on success in assembling the gene space and repetitive elements. A recent increase in Illumina read length to around 150 bp allowed us to attempt de novo assemblies with a larger range of k-mers, up to 127 bp. We applied these methods to Illumina paired-end sequencing read sets of fungal strains of Paracoccidioides brasiliensis and other species. By visualizing the results in simple plots, we were able to track the effect of changing k-mer size and assembly program, and to demonstrate how such plots can readily reveal discontinuities or other unexpected characteristics that assembly programs can present in practice, especially when they are used in a traditional molecular

  7. Corrosion inhibitors for intermediate cooling systems

    Energy Technology Data Exchange (ETDEWEB)

    Falk, I.; Suhr, L.


    The selected inhibitors were tested for heat and radiation stability and corrosion protection on the bench scale. Based on the results from these tests two of the products were selected, Bycoguard 81 and Bycoguard MP4S for continuing corrosion tests in an autoclave loop at 90 degrees C and 120 degrees C. Oxygen saturated deionized water with an addition of 1 ppm chloride was recirculated in the loop. Samples of copper and carbon steel were exposed to the water in the autoclave for periods up to 10 weeks. The purpose of this project was to find a substitute for hydrazine and chromates. Besides good corrosion protection qualities the toxic and environmental effect of the inhibitors should be minimal. The investigation has shown that the copper inhibitor BTA (benzotriazole) loses its corrosion protection qualities at a water temperature of 120 degrees C. The protection effects at 90 degrees C were satisfactory for both of the materials. The corrosion rates measured were 0.01 mm/y or less for the copper and carbon steel samples. The environment in the autoclave during the testing was more corrosive than is to be found in intermediate cooling systems. Due to the low corrosion rates measured the two inhibitors are to be recommended as alternatives to hydrazine and chromates.

  8. Study on the By-product Produced During the Scale-up of Drug Intermediate L-Menthol Glyoxylate%二羟乙酸薄荷酯的制备过程中副产物的研究

    Institute of Scientific and Technical Information of China (English)

    龙中柱; 徐轶; 王春梅; 吴彦; 蔡水洪; 苏克曼


    The structure of the impurity in the preparation of L-menthol glyoxylate was identified by various spectroscopies. Furthermore, the cause and mechanism of the production of the impurity was discussed and the method for controlling the impurity lovel was suggested, providing the basis for the scale up of L-menthol glyoxylate.%利用波谱分析技术鉴定了二羟乙酸薄荷酯制备过程中的杂质结构,并由此推测该杂质产生的原因、机理,提出抑制形成该杂质的副反应的方法,为工业化大生产奠定了基础.

  9. / production

    Indian Academy of Sciences (India)

    François Arleo; Pol-Bernard Gossiaux; Thierry Gousset; Jörg Aichelin


    For more than 25 years /Ψ production has helped to sharpen our understanding of QCD. In proton induced reaction some observations are rather well understood while others are still unclear. The current status of the theory of /Ψ production will be sketched, paying special attention to the issues of formation time and /Ψ re-interaction in a nuclear medium.

  10. Do female Nicrophorus vespilloides reduce direct costs by choosing males that mate less frequently? (United States)

    Mazué, G. P. F.; Carter, M. J.; Head, M. L.; Moore, A. J.; Royle, N. J.


    Sexual conflict occurs when selection to maximize fitness in one sex does so at the expense of the other sex. In the burying beetle Nicrophorus vespilloides, repeated mating provides assurance of paternity at a direct cost to female reproductive productivity. To reduce this cost, females could choose males with low repeated mating rates or smaller, servile males. We tested this by offering females a dichotomous choice between males from lines selected for high or low mating rate. Each female was then allocated her preferred or non-preferred male to breed. Females showed no preference for males based on whether they came from lines selected for high or low mating rates. Pairs containing males from high mating rate lines copulated more often than those with low line males but there was a negative relationship between female size and number of times she mated with a non-preferred male. When females bred with their preferred male the number of offspring reared increased with female size but there was no such increase when breeding with non-preferred males. Females thus benefited from being choosy, but this was not directly attributable to avoidance of costly male repeated mating. PMID:26979560

  11. A Decision Support System to Choose Optimal Release Cycle Length in Incremental Software Development Environments

    Directory of Open Access Journals (Sweden)

    Avnish Chandra Suman


    Full Text Available In the last few years it has been seen that many software vendors have started delivering projects incrementally with very short release cycles. Best examples of success of this approach has been Ubuntu Operating system that has a 6 months release cycle and popular web browsers such as Google Chrome, Opera, Mozilla Firefox. However there is very little knowledge available to the project managers to validate the chosen release cycle length. We propose a decision support system that helps to validate and estimate release cycle length in the early development phase by assuming that release cycle length is directly affected by three factors, (i choosing right requirements for current cycle, (ii estimating proximal time for each requirement, (iii requirement wise feedback from last iteration based on product reception, model accuracy and failed requirements. We have altered and used the EVOLVE technique proposed by G. Ruhe to select best requirements for current cycle and map it to time domain using UCP (Use Case Points based estimation and feedback factors. The model has been evaluated on both in-house as well as industry projects.

  12. Who chooses a consumer-directed health plan? (United States)

    Barry, Colleen L; Cullen, Mark R; Galusha, Deron; Slade, Martin D; Busch, Susan H


    Consumer-directed health plans (CDHPs) hold the promise of reining in health spending by giving consumers a greater stake in health care purchasing, yet little is known about employers' experience with these products. In examining the characteristics of those selecting a CDHP offered by one large employer, we found stronger evidence of selection than has been identified in prior research. Our findings suggest that in the context of plan choice, CDHPs may offer little opportunity to greatly lower employers' cost burden, and they highlight concerns about the potential for risk segmentation and the value of conferring preferential tax treatment to CDHPs.

  13. 3ds Max design architectural visualization for intermediate users

    CERN Document Server

    Smith, Brian L


    Learn time-saving techniques and tested production-ready tips for maximum speed and efficiency in creating professional-level architectural visualizations in 3ds Max. Move from intermediate to an advanced level with specific and comprehensive instruction with this collaboration from nine different authors from around the world. Get their experience and skills in this full-color book, which not only teaches more advanced features, but also demonstrates the practical applications of those features to get readers ready for a real production environment. Fully updated for the most recent version o

  14. Empirical or rational truffle cultivation? It is time to choose.

    Directory of Open Access Journals (Sweden)

    Gerard Chevalier


    Full Text Available Aim of study: The aim of this study was to finalize a new method of truffle cultivation in order to obtain an earlier, more regular and  sizeable production of high quality fruiting bodies. Area of study: The experimentation was carried out in France (country of Dordogne, south-western  France  and Italy (country of  Marches,   eastern central Italy for more than one  decade.Material and methods: For the first time the method is based on scientific data on truffle biology particularly: the dynamic system of mycorrhization by the truffle and by other fungi;  the saprophytic capability of the truffle; the ability of its mycelium for decomposing certain minerals and organic materials in the “brûlés”.The basic principle concern the work of the soil and the upkeep of the root system: to work the soil  immediately after the plantation of mycorrhizal seedlings, deeply enough, with adapted tools,  in order to do not compact the soil,  aerate it,  favour the production of deep fruiting bodies not exposed to high temperatures, dryness, frost, parasites… ;  cut accurately  the roots in order to regenerate them and consequently to provide food for the truffle mycelium.Main results: The result has been a new cultivation method designated “differentiated” and called “MRT”, with adapted work of the soil on the lines of plantation and upkeep of the grass between them,  to maintain the cohabitation between areas where the mycelium is present, from those where it is absent.Research highlights: Research is going on to improve   the techniques and particularly finalize tools more precise and more adapted for working the soil and maintaining  the root system in a  best way.  Keywords: truffle; production; nutrition; soil, root system; cultivation tools. 

  15. Choosing a Primary Health Care Provider (PCP): A Guide for Young Women (United States)

    ... Gynecology Medical Conditions Nutrition & Fitness Emotional Health Choosing a Primary Health Care Provider (PCP): General Information Posted ... taking care of yourself. Why do I need a PCP? You need a PCP so that your ...

  16. Choosing goals, not rules: deciding among rule-based action plans. (United States)

    Klaes, Christian; Westendorff, Stephanie; Chakrabarti, Shubhodeep; Gail, Alexander


    In natural situations, movements are often directed toward locations different from that of the evoking sensory stimulus. Movement goals must then be inferred from the sensory cue based on rules. When there is uncertainty about the rule that applies for a given cue, planning a movement involves both choosing the relevant rule and computing the movement goal based on that rule. Under these conditions, it is not clear whether primates compute multiple movement goals based on all possible rules before choosing an action, or whether they first choose a rule and then only represent the movement goal associated with that rule. Supporting the former hypothesis, we show that neurons in the frontoparietal reach areas of monkeys simultaneously represent two different rule-based movement goals, which are biased by the monkeys' choice preferences. Apparently, primates choose between multiple behavioral options by weighing against each other the movement goals associated with each option.

  17. Choosing a Primary Health Care Provider (PCP): A Guide for Young Men (United States)

    ... Health Medical Conditions Nutrition & Fitness Emotional Health Choosing a Primary Health Care Provider (PCP): General Information Posted ... help address your problems. Why do I need a PCP? You need a PCP so that your ...

  18. Causes and Consequences of Choosing Different Assurance Providers: An International Study of Sustainability Reporting

    NARCIS (Netherlands)

    P.M. Perego (Paolo)


    textabstractAn increasing number of companies voluntary disclose information about their social and environment performance in sustainability reports. This study investigates the causes and consequences of choosing different assurance providers for companies seeking independent verification of their

  19. Investigation of Mesh Choosing Parameters in Screen Printing System

    Directory of Open Access Journals (Sweden)

    Ahmet AKGÜL


    Full Text Available The mesh, which is made by weaving of natural silk, plastic, or metal fibers, is basic material for screen-printing. Image is created on stretched on a frame in screen-printing. Mesh should be selected correctly for a high quality printing. Therefore, substrates, types of print job and mesh parameters have importance. Need to know more about to mesh, yarn type, yarn thickness, frequency of weaving, stretching tension, the kind of weaving, etc. In this study, for a high quality screen-printing, mesh variables examined in detail and optimum conditions indicated, with the aim of increase productivity, minimize to losses time, material and labor. As a result, this information’s for obtaining a high quality printing with screen-printing system have importance as a guide. Also resolution of the image, amount of print run and viscosity of the printing ink, factors affecting the selection of mesh.

  20. Language in use intermediate : classroom book

    CERN Document Server

    Doff, Adrian


    ach of the four levels comprises about 80 hours of class work, with additional time for the self-study work. The Teacher's Book contains all the pages from the Classroom Book, with interleaved teaching notes including optional activities to cater for different abilities. There is a video to accompany the Beginner, Pre-intermediate and Intermediate levels. Each video contains eight stimulating and entertaining short programmes, as well as a booklet of photocopiable activities. Free test material is available in booklet and web format for Beginner and Pre-intermediate levels. Visit or contact your local Cambridge University Press representative.

  1. Language in use intermediate : teacher's book

    CERN Document Server

    Doff, Adrian


    Each of the four levels comprises about 80 hours of class work, with additional time for the self-study work. The Teacher's Book contains all the pages from the Classroom Book, with interleaved teaching notes including optional activities to cater for different abilities. There is a video to accompany the Beginner, Pre-intermediate and Intermediate levels. Each video contains eight stimulating and entertaining short programmes, as well as a booklet of photocopiable activities. Free test material is available in booklet and web format for Beginner and Pre-intermediate levels. Visit or contact your local Cambridge University Press representative.

  2. Study of Model of Grey Decision Making to Choose Leading Industry of Cities

    Institute of Scientific and Technical Information of China (English)

    JinglongZhang; GuangyongChen; WeiGuo; GangXie


    The Leading industry influences the economic development of one city. This paper establishes a decision factor system of choosing leading industry of cities, applies related decision theory in Grey System and invents the procedure of choosing leading industry, which achieved a good practical effect. Afterwards, the city Tianmen acclaims the dress industry as Leading Industry in its "The Tenth Five-Year Plan for Economic and Social Development of City TianMen".

  3. Reactive nitrogen intermediates suppress the primary immunologic response to Listeria. (United States)

    Gregory, S H; Wing, E J; Hoffman, R A; Simmons, R L


    Reactive nitrogen intermediates (RNI), e.g., nitric oxide derived from a terminal guanido nitrogen atom of L-arginine, exhibit potent antimicrobial activity in vitro. The function of these intermediates in host defenses in vivo, however, is presently unclear. Experiments were undertaken to determine the role of RNI in the resolution of primary listerial infections of the liver. Serum RNI levels were elevated significantly in mice infected with Listeria monocytogenes. Moreover, a marked increase in RNI production was found in cultures of the parenchymal, as well as the nonparenchymal, liver cells obtained from Listeria-infected mice. RNI did not kill Listeria treated directly, however, nor were they a factor in the listericidal activity exhibited by hepatic cells. Rather, the elevated production of RNI during primary infection appeared to promote the replication of Listeria in vivo. Mice administered NG-monomethyl-L-arginine, a competitive inhibitor of RNI production, exhibited a 10- and a 100-fold reduction in the number of Listeria in their lives on days 3 and 7 postinfection, respectively. In vitro, NG-monomethyl-L-arginine stimulated the Ag-specific proliferation of T lymphocytes derived from Listeria-infected mice at concentrations that inhibited RNI production. These latter findings suggest that the elevated production of RNI during primary listerial infections suppresses host defenses by diminishing the proliferation and, consequently, the biologic response of immune cell populations.

  4. Laboratory automation in clinical bacteriology: what system to choose? (United States)

    Croxatto, A; Prod'hom, G; Faverjon, F; Rochais, Y; Greub, G


    Automation was introduced many years ago in several diagnostic disciplines such as chemistry, haematology and molecular biology. The first laboratory automation system for clinical bacteriology was released in 2006, and it rapidly proved its value by increasing productivity, allowing a continuous increase in sample volumes despite limited budgets and personnel shortages. Today, two major manufacturers, BD Kiestra and Copan, are commercializing partial or complete laboratory automation systems for bacteriology. The laboratory automation systems are rapidly evolving to provide improved hardware and software solutions to optimize laboratory efficiency. However, the complex parameters of the laboratory and automation systems must be considered to determine the best system for each given laboratory. We address several topics on laboratory automation that may help clinical bacteriologists to understand the particularities and operative modalities of the different systems. We present (a) a comparison of the engineering and technical features of the various elements composing the two different automated systems currently available, (b) the system workflows of partial and complete laboratory automation, which define the basis for laboratory reorganization required to optimize system efficiency, (c) the concept of digital imaging and telebacteriology, (d) the connectivity of laboratory automation to the laboratory information system, (e) the general advantages and disadvantages as well as the expected impacts provided by laboratory automation and (f) the laboratory data required to conduct a workflow assessment to determine the best configuration of an automated system for the laboratory activities and specificities.

  5. Choosing and using citation and bibliographic database software (BDS). (United States)

    Hernandez, David A; El-Masri, Maher M; Hernandez, Cheri Ann


    The diabetes educator/researcher is faced with a proliferation of diabetes articles in various journals, both online and in print. Keeping track of cited references and remembering how to cite the references in text and the bibliography can be a daunting task for the new researcher and a tedious task for the experienced researcher. The challenge is to find and use a technology, such as bibliographic database software (BDS), which can help to manage this information overload. This article focuses on the use of BDS for the diabetes educator who is undertaking research. BDS can help researchers access and organize literature and make literature searches more efficient and less time consuming. Moreover, the use of such programs tends to reduce errors associated with the complexity of bibliographic citations and can increase the productivity of scholarly publications. The purpose of this article is to provide an overview of BDS currently available, describe how it can be used to aid researchers in their work, and highlight the features of different programs. It is important for diabetes educators and researchers to explore the many benefits of such BDS programs and consider their use to enhance the accuracy and efficiency of accessing and citing references of their research work and publications. Armed with this knowledge, researchers will be able to make informed decisions about selecting BDS which will meet their usage requirements.

  6. Simplifying biochemical models with intermediate species

    DEFF Research Database (Denmark)

    Feliu, Elisenda; Wiuf, Carsten


    canonical model that characterizes crucial dynamical properties, such as mono- and multistationarity and stability of steady states, of all models in the class. We show that if the core model does not have conservation laws, then the introduction of intermediates does not change the steady...... techniques, we study systematically the effects of intermediate, or transient, species in biochemical systems and provide a simple, yet rigorous mathematical classification of all models obtained from a core model by including intermediates. Main examples include enzymatic and post-translational modification...... systems, where intermediates often are considered insignificant and neglected in a model, or they are not included because we are unaware of their existence. All possible models obtained from the core model are classified into a finite number of classes. Each class is defined by a mathematically simple...

  7. The second national audit of intermediate care. (United States)

    Young, John; Gladman, John R F; Forsyth, Duncan R; Holditch, Claire


    Intermediate care services have developed internationally to expedite discharge from hospital and to provide an alternative to an emergency hospital admission. Inconsistencies in the evidence base and under-developed governance structures led to concerns about the care quality, outcomes and provision of intermediate care in the NHS. The National Audit of Intermediate Care was therefore established by an interdisciplinary group. The second national audit reported in 2013 and included crisis response teams, home-based and bed-based services in approximately a half of the NHS. The main findings were evidence of weak local strategic planning, considerable under-provision, delays in accessing the services and lack of mental health involvement in care. There was a very high level of positive patient experience reported across all types of intermediate care, though reported involvement with care decisions was less satisfactory.

  8. Intermediate/Advanced Research Design and Statistics (United States)

    Ploutz-Snyder, Robert


    The purpose of this module is To provide Institutional Researchers (IRs) with an understanding of the principles of advanced research design and the intermediate/advanced statistical procedures consistent with such designs

  9. Directional spread parameter at intermediate water depth

    Digital Repository Service at National Institute of Oceanography (India)

    SanilKumar, V.; Deo, M.C.; Anand, N.M.; AshokKumar, K.

    The characteristics of directional spread parameters at intermediate water depth are investigated based on a cosine power '2s' directional spreading model. This is based on wave measurements carried out using a Datawell directional waverider buoy...

  10. Transport code and nuclear data in intermediate energy region

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Akira; Odama, Naomitsu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Maekawa, F.; Ueki, K.; Kosaka, K.; Oyama, Y.


    We briefly reviewed the problems of intermediate energy nuclear data file and transport codes in connection with processing of the data. This is a summary of our group in the task force on JENDL High Energy File Integral Evaluation (JHEFIE). In this article we stress the necessity of the production of intermediate evaluated nuclear data file up to 3 GeV for the application of accelerator driven transmutation (ADT) system. And also we state the necessity of having our own transport code system to calculate the radiation fields using these evaluated files from the strategic points of view to keep our development of the ADT technology completely free from other conditions outside of our own such as imported codes and data with poor maintenance or unknown accuracy. (author)

  11. Design for the Environment Products (Raw Data) (United States)

    U.S. Environmental Protection Agency — This dataset contains a list of products that carry the Design for the Environment (DfE) label. This mark enables consumers to quickly identify and choose products...

  12. Design for the Environment Products (Online Search) (United States)

    U.S. Environmental Protection Agency — This dataset contains a list of products that carry the Design for the Environment (DfE) label. This mark enables consumers to quickly identify and choose products...

  13. Choosing the right green roof media for water quality

    Energy Technology Data Exchange (ETDEWEB)

    Hunt, W.F.; Hathaway, A.M.; Smith, J.T.; Calabria, J. [North Carolina State Univ., Raleigh, NC (United States). Dept. of Biological and Agricultural Engineering


    Due to the large concentrations of a variety of contaminants entering streams and rivers, stormwater is a significant contributor to the impairment of North Carolina (NC) waters. Pollutants range from pesticides and nutrients to oils and petroleum products to construction chemicals and sediment which are evident in fish kills, contamination of drinking water supplies, and deterioration of wildlife habitats. One of the major tools to improve storm water quality are stormwater best management practices (BMPs). BMPs include bioretention areas, wet and dry detention ponds, constructed wetlands, and sand filters. One option for urban BMPs is the green roof which uses rooftop square footage that would not otherwise be available on the ground. A research project was conducted that tests two field green roofs in Raleigh and Asheville, NC. In addition, a laboratory test was conducted in 2004 and a plot study of three designer media was conducted in 2005 on the NC State University Campus in Raleigh, NC. The objectives of the research were to examine how different green roof media reduce concentrations of nitrogen and phosphorus, if the leaching rate of nitrogen and phosphorus from soil media of field green roofs decrease with time, and to determine whether green roofs can be used as nutrient reduction BMPs. This paper provided background information on previous green roof stormwater research, discussed each of the sites chosen for the study in detail and presented the field monitoring process and laboratory study methodology. This was followed by a detailed examination of the results. It was concluded that an optimal soil media can be established that balances plant growth with water quality and quantity control. 16 refs., 2 tabs., 8 figs.

  14. Spliceosome discards intermediates via the DEAH box ATPase Prp43p. (United States)

    Mayas, Rabiah M; Maita, Hiroshi; Semlow, Daniel R; Staley, Jonathan P


    To promote fidelity in nuclear pre-mRNA splicing, the spliceosome rejects and discards suboptimal substrates that have engaged the spliceosome. Whereas DExD/H box ATPases have been implicated in rejecting suboptimal substrates, the mechanism for discarding suboptimal substrates has remained obscure. Corroborating evidence that suboptimal, mutated lariat intermediates can be exported to the cytoplasm for turnover, we have found that the ribosome can translate mutated lariat intermediates. By glycerol gradient analysis, we have found that the spliceosome can dissociate mutated lariat intermediates in vivo in a manner that requires the DEAH box ATPase Prp43p. Through an in vitro assay, we demonstrate that Prp43p promotes the discard of suboptimal and optimal 5' exon and lariat intermediates indiscriminately. Finally, we demonstrate a requirement for Prp43p in repressing splicing at a cryptic splice site. We propose a model for the fidelity of exon ligation in which the DEAH box ATPase Prp22p slows the flow of suboptimal intermediates through exon ligation and Prp43p generally promotes discard of intermediates, thereby establishing a pathway for turnover of stalled intermediates. Because Prp43p also promotes spliceosome disassembly after exon ligation, this work establishes a parallel between the discard of suboptimal intermediates and the dissociation of a genuine excised intron product.

  15. Production of Phenol from Benzene via Cumene (United States)

    Daniels, D. J.; And Others


    Describes an undergraduate chemistry laboratory experiment involving the production of phenol from benzene with the intermediate production of isopropylbenzene and isopropylbenzene hydroperoxide. (SL)

  16. Intermediate Q from soluble methane monooxygenase hydroxylates the mechanistic substrate probe norcarane: evidence for a stepwise reaction. (United States)

    Brazeau, B J; Austin, R N; Tarr, C; Groves, J T; Lipscomb, J D


    Norcarane is a valuable mechanistic probe for enzyme-catalyzed hydrocarbon oxidation reactions because different products or product distributions result from concerted, radical, and cation based reactions. Soluble methane monooxygenase (sMMO) from Methylosinus trichosporium OB3b catalyzes the oxidation of norcarane to afford 3-hydroxymethylcyclohexene and 3-cycloheptenol, compounds characteristic of radical and cationic intermediates, respectively, in addition to 2- and 3-norcaranols. Past single turnover transient kinetic studies have identified several optically distinct intermediates from the catalytic cycle of the hydroxylase component of sMMO. Thus, the reaction between norcarane and key reaction intermediates can be directly monitored. The presence of norcarane increases the rate of decay of only one intermediate, the high-valent bis-mu-oxo Fe(IV)(2) cluster-containing species compound Q, showing that it is responsible for the majority of the oxidation chemistry. The observation of products from both radical and cationic intermediates from norcarane oxidation catalyzed by sMMO is consistent with a mechanism in which an initial substrate radical intermediate is formed by hydrogen atom abstraction. This intermediate then undergoes either oxygen rebound, intramolecular rearrangement followed by oxygen rebound, or loss of a second electron to yield a cationic intermediate to which OH(-) is transferred. The estimated lower limit of 20 ps for the lifetime of the putative radical intermediate is in accord with values determined from previous studies of sterically hindered sMMO probes.

  17. Is offshoring driven by air emissions? Testing the pollution haven effect for imports of intermediates


    Michel, Bernhard


    The pollution haven effect reflects the idea that stricter environmental policies foster the relocation of polluting activities and imports of pollution-intensive products. This paper develops a new approach for testing this effect for imported intermediate materials. It adds to the existing literature on pollution havens through this specific focus on imports of intermediates, which is of particular interest in view of the rise of offshoring within global value chains. The estimation strateg...

  18. Effects of stocking density on intermediate culture of the razor clam Ensis arcuatus (Pharidae: Bivalvia)


    Da Costa Gonzalez, Fiz; Barreiro, Berta; Ojea, Justa; Novoa, Susana; Martinez-patino, Dorotea


    Commercial production of most bivalve species involves a phase of intermediate cultivation during which juveniles are grown under protected conditions until they can be transferred to the final grow-out location. Consequently, the aim of this study was investigating the effect of density on growth and survival in the intermediate culture of the razor clam Ensis arcuatus in raft. Two series of experiments were performed, using in the first experiment two holding systems: 5-L plastic bottles an...

  19. Partially folded intermediates during trypsinogen denaturation

    Directory of Open Access Journals (Sweden)

    Martins N.F.


    Full Text Available The equilibrium unfolding of bovine trypsinogen was studied by circular dichroism, differential spectra and size exclusion HPLC. The change in free energy of denaturation was = 6.99 ± 1.40 kcal/mol for guanidine hydrochloride and = 6.37 ± 0.57 kcal/mol for urea. Satisfactory fits of equilibrium unfolding transitions required a three-state model involving an intermediate in addition to the native and unfolded forms. Size exclusion HPLC allowed the detection of an intermediate population of trypsinogen whose Stokes radii varied from 24.1 ± 0.4 Å to 26.0 ± 0.3 Å for 1.5 M and 2.5 M guanidine hydrochloride, respectively. During urea denaturation, the range of Stokes radii varied from 23.9 ± 0.3 Å to 25.7 ± 0.6 Å for 4.0 M and 6.0 M urea, respectively. Maximal intrinsic fluorescence was observed at about 3.8 M urea with 8-aniline-1-naphthalene sulfonate (ANS binding. These experimental data indicate that the unfolding of bovine trypsinogen is not a simple transition and suggest that the equilibrium intermediate population comprises one intermediate that may be characterized as a molten globule. To obtain further insight by studying intermediates representing different stages of unfolding, we hope to gain a better understanding of the complex interrelations between protein conformation and energetics.

  20. Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids (United States)

    Jarchow-Choy, Sarah K; Koppisch, Andrew T; Fox, David T


    Isoprenoids constitute the largest class of natural products with greater than 55,000 identified members. They play essential roles in maintaining proper cellular function leading to maintenance of human health, plant defense mechanisms against predators, and are often exploited for their beneficial properties in the pharmaceutical and nutraceutical industries. Most impressively, all known isoprenoids are derived from one of two C5-precursors, isopentenyl diphosphate (IPP) or dimethylallyl diphosphate (DMAPP). In order to study the enzyme transformations leading to the extensive structural diversity found within this class of compounds there must be access to the substrates. Sometimes, intermediates within a biological pathway can be isolated and used directly to study enzyme/pathway function. However, the primary route to most of the isoprenoid intermediates is through chemical catalysis. As such, this review provides the first exhaustive examination of synthetic routes to isoprenoid and isoprenoid precursors with particular emphasis on the syntheses of intermediates found as part of the 2C-methylerythritol 4-phosphate (MEP) pathway. In addition, representative syntheses are presented for the monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), triterpenes (C30) and tetraterpenes (C40). Finally, in some instances, the synthetic routes to substrate analogs found both within the MEP pathway and downstream isoprenoids are examined. PMID:25009443

  1. A few philosophical ruminations on the human condition and choosing to live well

    Directory of Open Access Journals (Sweden)

    Blake E. Hestir


    Full Text Available The notion that life is meaningful through choosing to live well has historically received substantive attention in various philosophical circles, notably the ancient Greek philosophers Socrates, Plato, and Aristotle, and more recently several of the existentialists. In some respects, the idea of choosing to live well is a “thematization” of two widely-recognized, independent components of a meaningful life: happiness and authenticity. I develop this notion of choosing to live well by exploring, developing, and relating these conceptions of happiness and authenticity. By appealing to a very basic account of human nature that has found favor among a great number of people, I show how happiness and authenticity complement each other as conditions for the possibility of living meaningfully.

  2. [The social representations of the process of choosing leaders in the perspective of the nursing team]. (United States)

    de Moura, Gisela Maria Schebella Souto; de Magalhães, Ana Maria Müller; Souza, Dirciara Barañano; Dall'agnol, Clarice Maria


    This exploratory-descriptive, qualitative study was performed with the objective to analyze the social representation of the process of choosing leaders among nursing workers of a university hospital. The information was obtained through free word association and open interviews. For the purposes of this study, thematic content analysis was performed, guided by the Social Representations Theory. Through this focus the following category emerged: division of the nursing team - the input and output of the process of choosing leaders. The category consists of a crystallization of the social representation of the subject, anchored in elements related to leadership, impartiality, change, knowledge, trust and humanization. The idea of leadership is highlighted as inducing a movement in the division of the team as it is associated with the process of choosing leaders for an environment of communication, suitable for integrating the team and recognizing potential leaders.

  3. [Dentistry students' reasons for choosing dentistry as a career in Damascus University]. (United States)

    Mashlah, A M


    This cross-sectional questionnaire survey assessed the motives for choosing dentist as a profession among dentistry students at Damascus University, Syrian Arab Republic. A total of 408 undergraduate students (233 males and 175 females) aged 18-23 years were selected randomly from students in the second, third and fourth years of dentistry study. They completed a questionnaire that enquired about their reasons for studying dentistry as well as their sociodemographic characteristics. The number of admissions in females had increased over the 3 years. Most parents of the students were university-educated. The main motivation for choosing dentistry was as a means to achieve personal goals, including getting a good job abroad, having financial independence, and attaining a good reputation. There were significant differences between the sexes with regard to the reasons for choosing dentistry.

  4. Outflow forces in intermediate mass star formation

    CERN Document Server

    van Kempen, T A; van Dishoeck, E F; Kristensen, L E; Belloche, A; Klaassen, P D; Leurini, S; Jose-Garcia, I San; Aykutalp, A; Choi, Y; Endo, A; Frieswijk, W; Harsono, D; Karska, A; Koumpia, E; van der Marel, N; Nagy, Z; Perez-Beaupuits, J P; Risacher, C; van Weeren, R J; Wyrowski, F; Yildiz, U A; Guesten, R; Boland, W; Baryshev, A


    Intermediate mass protostarsprovide a bridge between theories of low- and high-mass star formation. Emerging molecular outflows can be used to determine the influence of fragmentation and multiplicity on protostellar evolution through the correlation of outflow forces of intermediate mass protostars with the luminosity. The aim of this paper is to derive outflow forces from outflows of six intermediate mass protostellar regions and validate the apparent correlation between total luminosity and outflow force seen in earlier work, as well as remove uncertainties caused by different methodology. By comparing CO 6--5 observations obtained with APEX with non-LTE radiative transfer model predictions, optical depths, temperatures, densities of the gas of the molecular outflows are derived. Outflow forces, dynamical timescales and kinetic luminosities are subsequently calculated. Outflow parameters, including the forces, were derived for all sources. Temperatures in excess of 50 K were found for all flows, in line wi...

  5. The ARES High-level Intermediate Representation

    Energy Technology Data Exchange (ETDEWEB)

    Moss, Nicholas David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    The LLVM intermediate representation (IR) lacks semantic constructs for depicting common high-performance operations such as parallel and concurrent execution, communication and synchronization. Currently, representing such semantics in LLVM requires either extending the intermediate form (a signi cant undertaking) or the use of ad hoc indirect means such as encoding them as intrinsics and/or the use of metadata constructs. In this paper we discuss a work in progress to explore the design and implementation of a new compilation stage and associated high-level intermediate form that is placed between the abstract syntax tree and when it is lowered to LLVM's IR. This highlevel representation is a superset of LLVM IR and supports the direct representation of these common parallel computing constructs along with the infrastructure for supporting analysis and transformation passes on this representation.

  6. Experimental Studies of Toxicity on HNIW and Its Intermediates

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ying; CHEN Shu-sen; JIN Shao-hua; CUI Zhao-kuan


    The polycyclic nitramine hexanitrohexaazaisowurtane(HNIW) is a compound of high energy density. HNIW can replace 1, 3, 5-trinitro-1, 3, 5-triazacyclohexane(RDX)or HMX, but its toxicity is unknown. In this paper,HNIW, hexabenzylhexaazaisowurtzitane ( HBIW ), tetraacetyldibenzulhexaazaisowurtzitane ( TADBIW ), tetraacetyldiformylhexaazaisowurtzitane(TADFIW) and tetraacetylhexaazaisowurtzitane(TAIW), which are intermediates of the synthesis of the HNIW, were selected as the tested objects in acute toxicity test, acute eye stimulation test and skin irritation test according to the standards of "chemical product testing method-401: acute oral toxicity test", "chemical product testing means-405: acute eye irritation/corrosion test" and "chemical product testing means-404: acute dermal irritation/corrosion test" of National Circumstance Protect Bureau. The results show that all of the five objects have no toxicity, no stimulation to eye and skin under the tested conditions.

  7. Intermediate mass fragment emission in Fe + Au collisions.

    Energy Technology Data Exchange (ETDEWEB)

    Sangster, T. C.; Britt, H. C.; Fields, D. J.; Hansen, L. F.; Lanier, R. G.; Namboodiri, M. N.; Remington, B. A.; Webb, M. L.; Begemann-Blaich, M.; Blaich, T.; Fowler, M. M.; Wilhelmy, J. B.; Chan, Y. D.; Dacal, A.; Harmon, A.; Pouliot, J.; Stokstad, R. G.; Kaufman, S.; Videbaek, F.; Fraenkel, Z.; Peilert, G.; Stocker, H.; Greiner, W.; Physics; LLNL; LANL; LBL; Weizmann Inst. of Science; Inst. fur Theoretische Physik der Univ.


    Experimental results are presented on the charge, velocity, and angular distributions of intermediate mass fragments (IMFs) for the reaction Fe+Au at bombarding energies of 50 and 100 MeV/nucleon. Results are compared to the quantum molecular dynamics (QMD) model and a modified QMD which includes a Pauli potential and follows the subsequent statistical decay of excited reaction products. The more complete model gives a good representation of the data and suggests that the major source of IMFs at large angles is due to multifragmentation of the target residue.

  8. Carbonyl Sulfides as Possible Intermediates in the Photolysis of Oxathiiranes

    DEFF Research Database (Denmark)

    Carlsen, Lars; Snyder, J. P.; Holm, A.


    of sulfine to ketone via the oxathiirane and the subsequent blue intermediate implies the absence of triplet and biradical singlet transients. The unknown carbonyl sulfide functionality, R2C&z.dbnd;O&z.dbnd;S, thereby emerges as a strong candidate for producing the visible absorption. Comparison of the wave...... functions for CH2&z.dbnd;S&z.dbnd;O and CH2&z.dbnd;O&z.dbnd;S arising from MNDO limited CI geometry optimizations leads to the conclusion that the carbonyl sulfide structure is best described as a zwitterion rather than as a singlet biradical. The failure to observe cycloaddition products between the blue...

  9. The Pseudouridine Synthases Proceed through a Glycal Intermediate. (United States)

    Veerareddygari, Govardhan Reddy; Singh, Sanjay K; Mueller, Eugene G


    The pseudouridine synthases isomerize (U) in RNA to pseudouridine (Ψ), and the mechanism that they follow has long been a question of interest. The recent elucidation of a product of the mechanistic probe 5-fluorouridine that had been epimerized to the arabino isomer suggested that the Ψ synthases might operate through a glycal intermediate formed by deprotonation of C2'. When that position in substrate U is deuterated, a primary kinetic isotope effect is observed, which indisputably indicates that the proposed deprotonation occurs during the isomerization of U to Ψ and establishes the mechanism followed by the Ψ synthases.

  10. Choosing surgery

    DEFF Research Database (Denmark)

    Thorstensson, Carina; Lohmander, L; Frobell, Richard


    ABSTRACT: BACKGROUND: The objective was to understand patients' views of treatment after acute anterior cruciate ligament (ACL) injury, and their reasons for deciding to request surgery despite consenting to participate in a randomised controlled trial (to 'cross-over'). METHODS: Thirty-four in......-depth qualitative interviews were conducted with young (aged 18-35), physically active individuals with ACL rupture who were participating in a RCT comparing training and surgical reconstruction with training only. 22/34 were randomised to training only but crossed over to surgery. Of these, 11 were interviewed...... before surgery, and 11 were interviewed at least 6 months after surgery. To provide additional information, 12 patients were interviewed before randomisation. Interviews were audio-recorded, transcribed and analysed using the Framework approach. RESULTS: Strong preference for surgery was commonplace...

  11. Choosing Independence

    Institute of Scientific and Technical Information of China (English)


    Milo Djukanovic, Prime Minister of Montenegro, won a key referendum May 21 when voters in his tiny, mountainous nation endorsed a plan to split from Serbia and become an independent state. This marked a final step in the breakup of the former Yugoslavia formed by six republics.

  12. [Choosing contraception]. (United States)

    Gonzalez Velez, A C


    The development of contraception has allowed women to think about and experience motherhood not as their destiny but as an option. Humans have always been interested in controlling their fertility. Writings unearthed in the 18th century demonstrated the interest of the ancient Egyptians and Greeks in fertility control. The oral contraceptive (OC) pill, developed in the 1950s by Pincus and Rock, has allowed millions of women to avoid unwanted pregnancy. Since 1960, when the oral contraceptive Enovid was first marketed in the US, over 200 million women throughout the world have used OCs. Modern formulations have low hormone doses, which has minimized side effects. OCs now have an effectiveness of 98%. The method is controlled by the woman, permitting autonomous decisions about pregnancy. Currently, in Colombia, 12.9% of women in union use OCs, 25.7% are sterilized, 11.1% each use IUDs and traditional methods, 4.3% use condoms, 2.5% use injectables, 1.4% use vaginal tablets, 0.7% each use Norplant and vasectomy, and 1.8% use other methods. 27.8% use no method. OCs can be used as an emergency method in case of rape, an unexpected sexual encounter, or failure of another method. When used as a postcoital method, OCs must be taken within 72 hours of unprotected sexual intercourse.

  13. Intermediate-energy nuclear chemistry workshop

    Energy Technology Data Exchange (ETDEWEB)

    Butler, G.W.; Giesler, G.C.; Liu, L.C.; Dropesky, B.J.; Knight, J.D.; Lucero, F.; Orth, C.J.


    This report contains the proceedings of the LAMPF Intermediate-Energy Nuclear Chemistry Workshop held in Los Alamos, New Mexico, June 23-27, 1980. The first two days of the Workshop were devoted to invited review talks highlighting current experimental and theoretical research activities in intermediate-energy nuclear chemistry and physics. Working panels representing major topic areas carried out indepth appraisals of present research and formulated recommendations for future research directions. The major topic areas were Pion-Nucleus Reactions, Nucleon-Nucleus Reactions and Nuclei Far from Stability, Mesonic Atoms, Exotic Interactions, New Theoretical Approaches, and New Experimental Techniques and New Nuclear Chemistry Facilities.

  14. Blue outliers among intermediate redshift quasars

    CERN Document Server

    Marziani, P; Stirpe, G M; Dultzin, D; Del Olmo, A; Martínez-Carballo, M A


    [Oiii]{\\lambda}{\\lambda}4959,5007 "blue outliers" -- that are suggestive of outflows in the narrow line region of quasars -- appear to be much more common at intermediate z (high luminosity) than at low z. About 40% of quasars in a Hamburg ESO intermediate-z sample of 52 sources qualify as blue outliers (i.e., quasars with [OIII] {\\lambda}{\\lambda}4959,5007 lines showing large systematic blueshifts with respect to rest frame). We discuss major findings on what has become an intriguing field in active galactic nuclei research and stress the relevance of blue outliers to feedback and host galaxy evolution.

  15. Governance-Default Risk Relationship and the Demand for Intermediated and Non-Intermediated Debt

    Directory of Open Access Journals (Sweden)

    Husam Aldamen


    Full Text Available This paper explores the impact of corporate governance on the demand for intermediated debt (asset finance, bank debt, non-bank private debt and non-intermediated debt (public debt in the Australian debt market. Relative to other countries the Australian debt market is characterised by higher proportions of intermediated or private debt with a lower inherent level of information asymmetry in that private lenders have greater access to financial information (Gray, Koh & Tong 2009. Our firm level, cross-sectional evidence suggests that higher corporate governance impacts demand for debt via the mitigation of default risk. However, this relationship is not uniform across all debt types. Intermediated debt such as bank and asset finance debt are more responsive to changes in governance-default risk relationship than non-bank and non-intermediated debt. The implication is that a firm’s demand for different debt types will reflect its governance-default risk profile.

  16. Manufacturing Companies Choose and Follow the Principle of the Instrument%制造类企业选购仪表遵循的原则

    Institute of Scientific and Technical Information of China (English)

    张建平; 李海平


    The electronic instrument is an important asset for the manufacturing companies, the choice of reasonable instrument can not only reduce the enterprise's fund pressure, and can effectively control the production cost, improve the market competitiveness of enterprise productsThe choose and buy of electronic instrument for enterprise is a very important work, if in the right way, it not only can choose to use for the enterprise, the work of instrument, can effectively reduce the direct costs of the enterprise, but also can greatly reduce the cost of potential. This paper puts forward the choose and buy the instrument type and its importance, and focuses on analyzing the principle of instrument of choose and buy.%电子仪表是制造类企业的主要资产,合理地选择仪表不但可以减轻企业的资金压力,而且可以有效控制生产成本,提高企业产品的市场竞争力。电子仪表的选购对企业来说是一项十分重要的工作,如果方法得当,不但可以为企业选出好用、管用的仪表,能够有效减少企业的直接支出费用,而且可以极大地减少潜在的费用。该文通过提出选购仪表类型及其重要性,重点分析选购仪表的原则。

  17. Patriarchal Leadership and Anti-Production Behavior of Workers in State-Own Enterprises:Intermediate Effect Based on Interactive Equity%国企背景下家长式领导与员工反生产行为:基于互动公平的中介效应

    Institute of Scientific and Technical Information of China (English)

    任迎伟; 李思羽


    以四川省多家大中型国有企业作为样本研究互动公平对家长式领导与员工反生产行为,结果表明:互动公平对员工反生产行为有负向的预测作用;家长式领导的三个维度(仁慈领导、德行领导、威权领导)与员工反生产行为之间有不同的相关关系,其中仁慈领导和德行领导对员工反生产行为有正向的预测作用,而威权领导对其则存在负向的预测作用;互动公平在家长式领导与员工反生产行为之间存在部分中介效应。由此,建议采取如下管理措施:合理调整领导风格,提高领导效能;建立良好的沟通机制、提高互动公平;量化高管招聘标准、寻找符合互动公平文化的高管。%Using several SOE in Sichuan Province as samples, this research explores the effect of interactive equity on patriarchal leadership and the anti-production behavior of staff and workers. The results show that interactive equity can negatively predict the anti-production behavior of staff and workers, and that the three dimensions of patriarchal leadership ( that is, benevolent, moral, and authoritative leadership ) is differently related to the anti-production behavior of staff and workers. Specifically, benevolent and moral leadership have a positive effect while authoritative leadership will have a negative effect. Interactive equity has an intermediate effect between patriarchal leadership and the anti-production behavior of staff and workers. Therefore, it is suggested that proper adaptation in leadership be made to increase efficiency, that communication mechanism be established to improve interactive equity, and that criteria be specified to employ capable high level management personnel.

  18. Using Drosophila for Studies of Intermediate Filaments. (United States)

    Bohnekamp, Jens; Cryderman, Diane E; Thiemann, Dylan A; Magin, Thomas M; Wallrath, Lori L


    Drosophila melanogaster is a useful organism for determining protein function and modeling human disease. Drosophila offers a rapid generation time and an abundance of genomic resources and genetic tools. Conservation in protein structure, signaling pathways, and developmental processes make studies performed in Drosophila relevant to other species, including humans. Drosophila models have been generated for neurodegenerative diseases, muscular dystrophy, cancer, and many other disorders. Recently, intermediate filament protein diseases have been modeled in Drosophila. These models have revealed novel mechanisms of pathology, illuminated potential new routes of therapy, and make whole organism compound screens feasible. The goal of this chapter is to outline steps to study intermediate filament function and model intermediate filament-associated diseases in Drosophila. The steps are general and can be applied to study the function of almost any protein. The protocols outlined here are for both the novice and experienced Drosophila researcher, allowing the rich developmental and cell biology that Drosophila offers to be applied to studies of intermediate filaments.

  19. C and C* among intermediate rings

    NARCIS (Netherlands)

    J. Sack; S. Watson


    Given a completely regular Hausdorff space X, an intermediate ring A(X) is a ring of real valued continuous functions between C*(X) and C(X). We discuss two correspondences between ideals in A(X) and z-filters on X, both reviewing old results and introducing new results. One correspondence, ZA, exte

  20. What Should be Taught in Intermediate Macroeconomics? (United States)

    de Araujo, Pedro; O'Sullivan, Roisin; Simpson, Nicole B.


    A lack of consensus remains on what should form the theoretical core of the undergraduate intermediate macroeconomic course. In determining how to deal with the Keynesian/classical divide, instructors must decide whether to follow the modern approach of building macroeconomic relationships from micro foundations, or to use the traditional approach…

  1. Synthesis of the key intermediate of ramelteon

    Institute of Scientific and Technical Information of China (English)

    Shan Bao Yu; Hao Min Liu; Yu Luo; Wei Lu


    Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me2S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.

  2. Korean Intermediate Course. Selected Newspaper Articles. (United States)

    Defense Language Inst., Washington, DC.

    The purpose of this material is to provide reading matter for the last phase of the Defense Language Institute's extended and intermediate courses in Korean. (See ED 024 943 for the Korean Basic Course, Lesson Units 1-112.) The content of this volume is current, introduces important vocabulary not encountered elsewhere in the courses, and calls…

  3. C and C* among intermediate rings

    NARCIS (Netherlands)

    Sack, J.; Watson, S.


    Given a completely regular Hausdorff space X, an intermediate ring A(X) is a ring of real valued continuous functions between C*(X) and C(X). We discuss two correspondences between ideals in A(X) and z-filters on X, both reviewing old results and introducing new results. One correspondence, ZA, exte

  4. Teaching Vocabulary and Morphology in Intermediate Grades (United States)

    Palumbo, Anthony; Kramer-Vida, Louisa; Hunt, Carolyn V.


    Direct vocabulary instruction of Tier 2 and Tier 3 words in intermediate-grade curricula is an important tool of literacy instruction because English is a language grafted from many roots and has not developed a one-to-one phoneme-grapheme correspondence. In addition to knowing graphemes and phonemes, students must formally learn words that cross…

  5. Changes to the Intermediate Accounting Course Sequence (United States)

    Davidson, Lesley H.; Francisco, William H.


    There is an ever-growing amount of information that must be covered in Intermediate Accounting courses. Due to recent accounting standards and the implementation of IFRS this trend is likely to continue. This report incorporates the results of a recent survey to examine the trend of spending more course time to cover this additional material.…

  6. Essays in corporate finance and financial intermediation

    NARCIS (Netherlands)

    Kempf, Elisabeth


    This thesis consists of three chapters in corporate finance and financial intermediation. The first two chapters explore sources of incentives and learning for finance professionals. Specifically, the first chapter studies how the option to go work for an investment bank affects the incentives of cr

  7. Intermediates and Generic Convergence to Equilibria

    DEFF Research Database (Denmark)

    Freitas, Michael Marcondes de; Wiuf, Carsten; Feliu, Elisenda


    Known graphical conditions for the generic or global convergence to equilibria of the dynamical system arising from a reaction network are shown to be invariant under the so-called successive removal of intermediates, a systematic procedure to simplify the network, making the graphical conditions...

  8. Bismuth phosphates as intermediate temperature proton conductors

    DEFF Research Database (Denmark)

    Huang, Yunjie; Christensen, Erik; Shuai, Qin


    Proton conducting electrolyte materials operational in the intermediate temperature range of 200-400 °C are of special interest for applications in fuel cells and water electrolysers. Bismuth phosphates in forms of polycrystalline powders and amorphous glasses are synthesized and investigated...

  9. Bridge: Intelligent Tutoring with Intermediate Representations (United States)


    Research and Development Center and Psychology Department University of Pittsburgh Pittsburgh, PA. 15260 The Artificial Intelligence and Psychology...problem never introduces more than one unfamiliar plan. Inteligent Tutoring With Intermediate Representations - Bonar and Cunniigbam 4 You must have a... Inteligent Tutoring With ntermediate Representations - Bonar and Cunningham 7 The requirements are specified at four differcnt levels, corresponding to

  10. Software Testing An ISEB Intermediate Certificate

    CERN Document Server

    Hambling, Brian


    Covering testing fundamentals, reviews, testing and risk, test management and test analysis, this book helps newly qualified software testers to learn the skills and techniques to take them to the next level. Written by leading authors in the field, this is the only official textbook of the ISEB Intermediate Certificate in Software Testing.

  11. Modern Persian: Intermediate Level, Vol. 2. (United States)

    Windfuhr, Gernot; And Others

    The second of three volumes of an intergrated course in intermediate Persian is presented. This volume encompasses material appropriate for students entering the second year of Persian studies who have strong preparation in elementary Persian. Verbal skills should be on a level which will allow comprehensive discussion of a topic using simple,…

  12. MNE Entrepreneurial Capabilities at Intermediate Levels

    DEFF Research Database (Denmark)

    Hoenen, Anne K.; Nell, Phillip Christopher; Ambos, Björn


    and on the heterogeneous information that is generated through dissimilar markets within the region. Our study opens up for an interesting discussion of the independence of these mechanisms. In sum, we contribute to the understanding of the entrepreneurial role of intermediate units in general and RHQs in particular....

  13. Intermediate Tamil: A Self-Instructional Method. (United States)

    Schiffman, Harold

    This self-instructional method for learning an intermediate level of Tamil is designed to follow an elementary level such as "Conversational Tamil." The material in this text concentrates on grammatical constructions not covered in that elementary text, particularly negatives of all kinds; in addition, this text uses the same transcription and the…

  14. On financial equilibrium with intermediation costs

    DEFF Research Database (Denmark)

    Markeprand, Tobias Ejnar


    This paper studies the set of competitive equilibria in financial economies with intermediation costs. We consider an arbitrary dividend structure, which includes options and equity with limited liabilities.We show a general existence result and upper-hemi continuity of the equilibrium correspond...

  15. Intermediality and politics in theatre and performance

    NARCIS (Netherlands)

    Dapp, G.S.


    This dissertation applies the concepts of intermediality and politics to five performances by Rimini Protokoll, Christoph Schlingensief, and Igneous, and analyzes the implications that emerge on both a significational and a theoretical level. Based on the specific mediality involved, it argues that

  16. Multiphase Gas in Intermediate Redshift Galaxies

    CERN Document Server

    Churchill, C W; Charlton, J; Januzzi, B; Churchill, Chris; Mellon, Rick; Charlton, Jane


    We present 40 quasar absorption line systems at intermediate redshifts (z~1), with focus on one of the most kinematically complex known, as examples of how the unique capabilities of space-based and ground-based facilities can be combined to glean much broader insights into astrophysical systems.

  17. Trusted intermediating agents in electronic trade networks

    NARCIS (Netherlands)

    Klos, T.B.; Alkemade, F.


    Electronic commerce and trading of information goods significantly impact the role of intermediaries: consumers can bypass intermediating agents by forming direct links to producers. One reason that traditional intermediaries can still make a profit, is that they have more knowledge of the market, s

  18. Intermediate Amharic Cultural Reader. Final Report. (United States)

    Leslau, Wolf

    This reader is intended to provide material for the intermediate-level student of Amharic, as well as to introduce the student to the cultural and social life of Ethiopia. The 39 texts were each prepared by a different student at Haile Selassie I University, thus providing the reader with a variety of language styles. The Amharic texts are…

  19. Empirical Investigation into Motives for Choosing Web-Based Distance Learning Programs (United States)

    Alkhattabi, Mona


    Today, in association with rapid social and economic changes, there is an increasing level of demand for distance and online learning programs. This study will focus on identifying the main motivational factors for choosing a web-based distance-learning program. Moreover, it will investigate how these factors relate to age, gender, marital status…

  20. Fuzzy Reasoning Methods by Choosing Different Fuzzy Counters and Analysis of Effect

    Institute of Scientific and Technical Information of China (English)


    Different fuzzy reasoning methods were gave by choosing different fuzzy counters. This article generally introduced the basic structure of fuzzy controller,and compared and analysised the reasoning effect of fuzzy reasoning methods and the effect of computer simulating control basicly on different fuzzy counters.

  1. Destined to Design? How and Why Australian Women Choose to Study Industrial Design (United States)

    Lockhart, Cathy; Miller, Evonne


    Despite over three decades of legislation and initiatives designed to tackle the traditional gender divide in the science, technology and design fields, only a quarter of the registered architects in Australia are women. There are no statistics available for other design disciplines, with little known about why women choose design as a career path…

  2. Choosing High-Yield Tasks for the Mathematical Development of Practicing Secondary Teachers (United States)

    Epperson, James A. Mendoza; Rhoads, Kathryn


    Many mathematics teacher educators encounter the challenge of creating or choosing mathematical tasks that evoke important mathematical insights and connections yet remain firmly grounded in school mathematics. This challenge increases substantially when trying to meet the needs of practicing secondary mathematics teachers pursuing graduate work…

  3. Choosing a Hospital for Surgery: The Importance of Information on Quality of Care

    NARCIS (Netherlands)

    Dijs-Elsinga, J.; Otten, W.; Versluijs, M.; Smeets, H.J.; Kievit, J.; Vree, R.; Made, W.J. van der; Marang-Van De Mheen, P.J.


    OBJECTIVE: To assess whether patients use information on quality of care when choosing a hospital for surgery compared with more general hospital information. METHODS: In this cross-sectional study in 3 Dutch hospitals, questionnaires were sent to 2122 patients who underwent 1 of 6 elective surgical

  4. Refined Method for Choosing a Security Solution for Mobile Application – Web Service Interactions


    Silvia Trif; Adrian Visoiu


    This paper aims to present a refined algorithm for choosing the appropriate security implementation for mobile applications connecting to web services. Common security scenarios are presented. Each scenario has several characteristics associated. The correlations between these security scenarios characteristics are computed and selected only the characteristics that are less correlated. The proposed algorithm inventories the available scenarios, inventories the requirements and selects the se...

  5. Why political context is key in determining the parties interest groups choose to collaborate with

    NARCIS (Netherlands)

    Otjes, Simon; Rasmussen, Anne


    When interest groups choose to collaborate with political parties what determines the type of party they opt to work with? Anne Rasmussen and Simon Otjes write that the two key elements shaping this decision are typically the ideological similarities between the interest group and the party, togethe

  6. Choosing Communication Portfolios to Accomplish Tasks: The Effects of Individual Differences (United States)

    Lee, Chei Sian; Goh, Dion Hoe-Lian; Chua, Alton Y. K; Luyt, Brendan


    The myriad of information communication technologies (ICTs) available today has changed the way students choose and use them. Specifically, individuals are increasingly relying on a mix of ICTs for communication to accomplish tasks. Yet, past studies on ICT use has largely assumed that people use a single ICT per task. We attempt to address this…

  7. Which Teachers Choose a Defined Contribution Pension Plan? Evidence from the Florida Retirement System (United States)

    Chingos, Matthew M.; West, Martin R.


    Since 2002, public school teachers in Florida have been permitted to choose between a defined benefit (DB) and a defined contribution (DC) retirement plan. We exploit this unique policy environment to study new teachers' revealed preferences over pension plan structures. Roughly 30 percent of teachers hired between 2003 and 2008 selected the DC…

  8. Elementary School-Age Children's Capacity To Choose Positive Diagnostic and Negative Diagnostic Tests. (United States)

    Samuels, Mark C.; McDonald, John


    Two experiments compared 10-year-olds' and adults' ability to choose positive and negative diagnostic tests over positive and negative nondiagnostic tests. Findings indicated that both age groups were more likely to prefer positive diagnostic tests over positive nondiagnostic tests, although only adults showed a significant preference for negative…

  9. Why Women Choose Information Technology Careers: Educational, Social, and Familial Influences. (United States)

    Turner, Sandra V.; Bernt, Phyllis W.; Pecora, Norma

    The educational, social, and familial influences that lead women to choose information technology (IT) careers were examined in an online survey. Of the 2,500 women who were employed in IT careers in 38 countries and who belonged to the IT professional organization, Systers, 275 responded to the online survey (11% response rate). The respondents…

  10. Effects of choosing academic assignments on a student with attention deficit hyperactivity disorder.



    The effects of choosing academic assignments on the undesirable behaviors manifested by a second-grade student with attention deficit hyperactivity disorder were analyzed. This study extended Dunlap et al.'s (1994) research on choice making as a form of antecedent control. A reversal design showed that undesirable behaviors decreased when the student was given a choice of academic assignments.

  11. Assignment Choice: Do Students Choose Briefer Assignments or Finishing What They Started? (United States)

    Hawthorn-Embree, Meredith L.; Skinner, Christopher H.; Parkhurst, John; O'Neil, Michael; Conley, Elisha


    Academic skill development requires engagement in effortful academic behaviors. Although students may be more likely to choose to engage in behaviors that require less effort, they also may be motivated to complete assignments that they have already begun. Seventh-grade students (N = 88) began a mathematics computation worksheet, but were stopped…

  12. How do individuals apply risk information when choosing among health care interventions?

    DEFF Research Database (Denmark)

    Gyrd-Hansen, Dorte; Kristiansen, Ivar Sønbø; Nexøe, Jørgen


    weighting of different types of risk information under various circumstances. The effect of presenting questions, and of explicitly formulating RRR, was analyzed. A preference for increases in RRR was demonstrated. There was a stronger inclination to choose the intervention that offered the highest RRR...

  13. First-year dental students’ motivation and attitudes for choosing the dental profession

    Directory of Open Access Journals (Sweden)

    Nadya Avramova


    Full Text Available Objective. To determine first-year dental students’ current motivation and attitudes for choosing the dental profession at the Faculty of Dental Medicine, Medical University – Sofia, Bulgaria. Material and methods. An anonymous questionnaire, consisting of 12 questions about students’ socio-demographic profile and their motivation for choosing dentistry, was administered to 119 first-year dental students at the Faculty of Dental Medicine of the Medical University of Sofia. The study was conducted at the beginning of the 2012-2013 academic year. The data was processed and analyzed with the following software: Microsoft Windows Server 2008 R2; Microsoft SQL Server 2008; Internet Information Server 7.5.; Microsoft SharePoint Server 2010. Results. The majority of the students (73% were self-motivated for choosing dentistry as a career; 61% of them did not have relatives in the medical profession; 43% chose dental medicine because it is a prestigious, humane and noble profession; 50% – for financial security; 59% – because of the independence that it provides. There were no significant differences in the motivation between males and females. Conclusion. Independence, financial security and ‘prestige’ were the predominant motivating factors in this group of first-year dental students. Determining the reasons for choosing dentistry has important implications for the selection and training of students as well as for their future job satisfaction.

  14. Econobiophysics - game of choosing. Model of selection or election process with diverse accessible information (United States)


    We propose several models applicable to both selection and election processes when each selecting or electing subject has access to different information about the objects to choose from. We wrote special software to simulate these processes. We consider both the cases when the environment is neutral (natural process) as well as when the environment is involved (controlled process). PMID:21892959

  15. A Method for Choosing an Initial Time Eigenstate in Classical and Quantum Systems

    Directory of Open Access Journals (Sweden)

    Mónica Noemí Jiménez-García


    Full Text Available A subject of interest in classical and quantum mechanics is the development of the appropriate treatment of the time variable. In this paper we introduce a method of choosing the initial time eigensurface and how this method can be used to generate time-energy coordinates and, consequently, time-energy representations for classical and quantum systems.

  16. Hydration Products and Mechanical Properties of Hydroceramics Solidified Waste for Simulated Non-alpha Low and Intermediate Level Radioactive Wastes%模拟非α低中放废液水合陶瓷固化体的水化产物和力学性能

    Institute of Scientific and Technical Information of China (English)

    王进; 洪明; 王军霞; 李玉香; 滕元成; 吴秀玲


    In this paper, simulated non- alpha low and intermediate level radioactive wastes was handled as curing object and that of "alkali-slag-coal fly ash-metakaolin" hydroceramics waste forms were prepared by hydrothermal synthesis method. The hydration products were analyzed by X ray diffraction. The composition of hydrates and the compressive strength of waste forms were determined and measured. The results indicate that the main crystalline phase of hydration products were analcite when the temperature was 150 to 180 ℃ and the salt content ratio was 0.10 to 0.30. Analcite diffraction peaks in hydration products is increasing when the temperature was raised and the reaction time prolonged. Strength test results show that the solidified waste forms have superior compressive strength. The compressive strength gradually decreased with the increase in salt content ratio in waste fornls.%以模拟非α低中放废液为固化处理对象,用水热法合成了非α低中放废液中和处理后沉淀的"碱-矿渣-粉煤灰-偏高岭土"水合陶瓷固化体。采用X射线衍射仪分析了固化体的水化产物,确定了水化产物的组成,并测试了固化体的抗压强度。研究结果表明:温度为150~180℃、废液沉淀与固化原材料的质量比值(即盐灰比)为0.10~0.30时,固化体水化产物的主要物相为方沸石,随着温度升高和反应时间延长,水化产物中方沸石的衍射峰不断增加。固化体抗压强度测试结果表明,该固化体具有较高的抗压强度,但盐灰比由0.10增加至0.30时,固化体抗压强度由26.33 MPa下降到8.46 MPa。

  17. The Comparison of Iranian and Foreign Students’ Motivations to Choose Dentistry Field of Study

    Directory of Open Access Journals (Sweden)

    Abdolreza Gilavand


    Full Text Available Background Because of some special and privileged attractions of dentistry discipline, the first choice of volunteers who want to enter university is dentistry. The students usually choose it regardless to their interests and talents. Therefore, this study aimed to investigate Iranian and Foreign student’s motivations to choose dentistry field of study. Materials and Methods We searched international databases such as PubMed, Scopus, EMBASE, Cochrane Library, and Iranian databases such as SID, Magiran, Iranmedex using a searching strategy during 2000 to 2015 years. Database without language restriction, since 2000 sources, with the MeSH term "Choose dentistry field" AND "Students". At first, in the initial search,152 articles were found, and finally, 51 of them which were related to the subject of this research were used. Results In general, the motivation of students to choose field of study in Iranain and Foreign students include the following:: an independent office or job independence, high economic income, appropriate social status,  job attractiveness of dentistry, appropriate job position, individual longing, help others, top rank of student in the university entrance exam, continue to study at specialized PhD in one of dentistry trends, successful marriage nd interest in the field of dentistry. Conclusion It seems that with regard to the high unemployment rate of university graduates in Iran, the most important incentives of applicants who want to enter the dentistry discipline are high income and  particular social prestige at this major. Moreover, high income and independent job situations are the most important factors in Foreign students for choosing this filed of study in the overseas studies.

  18. Choose and Book: a sociological analysis of 'resistance' to an expert system. (United States)

    Greenhalgh, Trisha; Stones, Rob; Swinglehurst, Deborah


    In 2004, the English Department of Health introduced a technology (Choose and Book) designed to help general practitioners and patients book hospital outpatient appointments. It was anticipated that remote booking would become standard practice once technical challenges were overcome. But despite political pressure and financial incentives, Choose and Book remained unpopular and was generally used reluctantly if at all. Policymakers framed this as a problem of 'clinician resistance'. We considered Choose and Book from a sociological perspective. Our dataset, drawn from a qualitative study of computer use in general practice, comprised background documents, field notes, interviews, clinical consultations (directly observed and videotaped) and naturally occurring talk relating to referral to hospital in four general practices. We used strong structuration theory, Giddens' conceptualisation of expert systems, and sensitivity to other sociological perspectives on technology, institutions and professional values to examine the relationship between the external environment, the evolving technology and actions of human agents (GPs, administrators, managers and patients). Choose and Book had the characteristics of an expert system. It served to 'empty out' the content of the consultation as the abstract knowledge it contained was assumed to have universal validity and to over-ride the clinician's application of local knowledge and practical wisdom. Sick patients were incorrectly assumed to behave as rational choosers, able and willing to decide between potential options using abstracted codified information. Our analysis revealed four foci of resistance: to the policy of choice that Choose and Book symbolised and purported to deliver; to accommodating the technology's socio-material constraints; to interference with doctors' contextual judgements; and to adjusting to the altered social relations consequent on its use. We conclude that 'resistance' is a complex phenomenon

  19. Is TW Pictoris really an intermediate polar?

    CERN Document Server

    Norton, A J


    We present the results of a long ROSAT HRI observation of the candidate intermediate polar TW Pic. The power spectrum shows no sign of either the previously proposed white dwarf spin period or the proposed binary orbital period (1.996 hr and 6.06 hr respectively). The limits to the X-ray modulation are less than 0.3% in each case. In the absence of a coherent X-ray pulsation, the credentials of TW Pic for membership of the intermediate polar subclass must be suspect. We further suggest that the true orbital period of the binary may be the shorter of the two previously suggested, and that the longer period may represent a quasi-periodic phenomenon associated with the accretion disc.

  20. Being back home after intermediate care

    DEFF Research Database (Denmark)

    Martinsen, Bente; Harder, Ingegerd; Norlyk, Annelise


    Older people may face many challenges and experience insecurity after discharge from hospital to home. To bridge the potential gap between general hospital and home, the concept ‘Intermediate Care’ (IC) was developed at the beginning of 2000. IC aims to safeguard older people from being discharged....... Transcripts were analysed using a phenomenological approach. The essential meaning of being back home after a stay in an IC unit was characterised by ‘uncertainty’. Four constituents emerged: ‘in a state of shock about coming home’, ‘dependence on informal helpers’, ‘a sense of isolation’, and ‘fear of losing...... functional ability permanently’. Key words: intermediate care, older people, discharge, interview, phenomenology...

  1. Discovery of the intermediate W boson

    CERN Multimedia


    Press conference on 25 January 1983 when the announcement was made of the discovery of the intermediate W boson at CERN. From right to left: Carlo Rubbia, spokesman of the UA1 experiment; Simon van der Meer, responsible for developing the stochastic cooling technique; Herwig Schopper, Director- General of CERN; Erwin Gabathuler, Research Director at CERN, and Pierre Darriulat, spokesman of the UA2 experiment, whose results confirmed those from Carlo Rubbia's experiment.

  2. Essays in corporate finance and financial intermediation



    This thesis consists of three chapters in corporate finance and financial intermediation. The first two chapters explore sources of incentives and learning for finance professionals. Specifically, the first chapter studies how the option to go work for an investment bank affects the incentives of credit rating analysts, and shows that this "revolving door" strengthens analysts' incentives to issue accurate ratings. The second chapter analyzes the value of experience for mutual fund managers a...

  3. International express student's book : pre-intermediate

    CERN Document Server

    Taylor, Liz


    The New Edition of International Express Pre-Intermediate retains all the keys features of this popular and successel four-level course. It combines engaging, up-to-date topics with a time-efficient and student-centred approach to language work, and clearly focused activities that reflect learner's real communicative needs - the ideal course for professional adults who use English for work, travel, and socializing.

  4. Capturing a flavivirus pre-fusion intermediate.

    Directory of Open Access Journals (Sweden)

    Bärbel Kaufmann


    Full Text Available During cell entry of flaviviruses, low endosomal pH triggers the rearrangement of the viral surface glycoproteins to a fusion-active state that allows the release of the infectious RNA into the cytoplasm. In this work, West Nile virus was complexed with Fab fragments of the neutralizing mAb E16 and was subsequently exposed to low pH, trapping the virions in a pre-fusion intermediate state. The structure of the complex was studied by cryo-electron microscopy and provides the first structural glimpse of a flavivirus fusion intermediate near physiological conditions. A radial expansion of the outer protein layer of the virion was observed compared to the structure at pH 8. The resulting approximately 60 A-wide shell of low density between lipid bilayer and outer protein layer is likely traversed by the stem region of the E glycoprotein. By using antibody fragments, we have captured a structural intermediate of a virus that likely occurs during cell entry. The trapping of structural transition states by antibody fragments will be applicable for other processes in the flavivirus life cycle and delineating other cellular events that involve conformational rearrangements.

  5. Empowering Learners to Choose the Difficulty Level of Problems Based on Their Learning Needs

    Directory of Open Access Journals (Sweden)

    Janet Mannheimer Zydney


    Full Text Available Research has found that increasing learner control offers several benefits, including increased motivation, attitude, and learning. The goal of the present study was to determine how prior math achievement influences students' selection of the difficulty level of problems within Math Pursuits, a hypermedia learning program. Math Pursuits was designed to help children understand mathematics by discovering how it relates to the world around them. The program presented each learner with an adjustable level of challenge, along with the necessary scaffolding to support success. The researchers hypothesized that students with lower math skills would choose to start with a lower difficultly level; whereas, students with higher math skills would begin the program by choosing a question with a higher level of difficulty. Results supported these hypotheses. This research also examined the motivational framework guiding students' selection of problem difficulty.

  6. Why do young Arabs in Denmark choose to study their heritage language at the university?

    DEFF Research Database (Denmark)

    Dhahir, Omar


    This article reports on a study of the phenomenon that an increasing number of young Arabs in Denmark are choosing to study their heritage language at the university. The study aimed at investigating three elements: the motivation behind choosing to study the heritage language at the university......; whether the informants had learned/maintained Arabic before starting at the university; and the role of the families in motivating the informants to learn and study Arabic. The informants are students just enrolled at the University of Southern Denmark in autumn 2012. A mixed method was used......: a quantitative method, where 18 informants completed a questionnaire, and a qualitative, where 11 out of the 18 were interviewed. The study found that the motivation behind the decision to study Arabic at the university is multiple, primarily to understand the holy book of Islam and Arabic culture, besides...

  7. ACOG Committee Opinion No. 444: choosing the route of hysterectomy for benign disease. (United States)


    Hysterectomies are performed vaginally, abdominally, or with laparoscopic or robotic assistance. When choosing the route and method of hysterectomy, the physicians should take into consideration how the procedure may be performed most safely and cost-effectively to fulfill the medical needs of the patient. Evidence demonstrates that, in general, vaginal hysterectomy is associated with better outcomes and fewer complications than laparoscopic or abdominal hysterectomy. When it is not feasible to perform a vaginal hysterectomy, the surgeon must choose between laparoscopic hysterectomy,robot-assisted hysterectomy, or abdominal hysterectomy. Experience with robot-assisted hysterectomy is limited at this time; more data are necessary to determine its role in the performance of hysterectomy. The decision to electively perform a salpingoophorectomy should not be influenced by the chosen route of hysterectomy and is not a contraindication to performing a vaginal hysterectomy.

  8. The capacity to choose: reformulating the concept of choice in economic theory

    Directory of Open Access Journals (Sweden)

    Mark S. Peacock


    Full Text Available Despite being conceived as a ‘theory of rational choice’, orthodox economics fails to ascribe to human beings the ability to choose in a meaningful sense, something philosophical approaches to economics have long noted and tried to remedy. Tony Lawson’s critical realism is one attempt at a remedy. If, following Lawson, one conceives of choice as a ‘capacity’ of human beings, critical realist analysis suggests a distinction between humans’ possession and their exercise of this capacity. If one can sustain this distinction, one should be able to distinguish cases in which agents actually exercise their capacity to choose from those in which they do not. Investigation of this distinction does not, however, lead to the desired distinction between such cases. Consequently, a reformulation of the notion of choice is required. An implication for economic theory – namely, the possibility of conceptualizing ‘exploitation’ – is discussed.

  9. A qualitative study of the factors that influence mothers when choosing drinks for their young children


    Hoare, Alexandria; Virgo-Milton, Monica; Boak, Rachel; Gold, Lisa; Waters, Elizabeth; Gussy, Mark; Calache, Hanny; Smith, Michael; de Silva, Andrea M


    Background The consumption of sweetened beverages is a known common risk factor for the development of obesity and dental caries in children and children consume sweet drinks frequently and in large volumes from an early age. The aim of this study was to examine factors that influence mothers when choosing drinks for their children. Method Semi-structured interviews (n = 32) were conducted with a purposive sample of mothers of young children from Victoria’s Barwon South Western Region (select...

  10. Motivation of foreign degree students to choose ABC University for their undergraduate studies


    Thapa, Suman; Phung, Mai Anh


    Every year, the number of foreign degree students is increasing in Finnish universities. These foreign students come from a wide range of nations all over the world. Being one of the best universities of applied sciences in Helsinki, Finland, each year ABC University receives applications of students from Vietnam, China, Nepal, Bangladesh, Russia, various African countries and so on. The aim of this qualitative research is to investigate why foreign degree students choose ABC University as th...

  11. Curbing overuse. Providers hail value of Choosing Wisely, but skeptics say initiative comes with risk. (United States)

    McKinney, Maureen


    The Choosing Wisely campaign, with participating medical societies, spotlighted a list of 135 potentially unnecessary procedures. Critics are questioning whether patients and physicians are seeing the guidelines and if they are leading to any changes. But Dr. Glen Stream, AAFP board chairman, says his group's participation was the right choice. "It's a proactive stance, driven by the medical profession, and it really does make conversations with patients easier."

  12. Multicultural desires? Parental negotiation of multiculture and difference in choosing secondary schools for their children


    Byrne, Bridget; De Tona, Carla


    This paper considers the ways in which parents talk about choosing secondary schools in three areas of Greater Manchester. It argues that this can be a moment when parents are considering their own attitudes to, and shaping their children's experiences of, multiculture. Multiculture is taken as the everyday experience of living with difference. The paper argues that multiculture needs to be understood as shaped not only by racialized, ethnic or religious difference (as it is commonly understo...

  13. Motives and career barriers choosing studies in Physics and Mathematics: gender aspects

    Directory of Open Access Journals (Sweden)

    Aldona, Augustiene


    Full Text Available This article discusses the concepts of professional motivation and career barriers from the gender point of view. The research problem is expressed in the following questions: what personal and socio-cultural factors motivate young people to choose Physics and Mathematics study programmes? Are there significant differences in expression of motives and career barriers among male and female students? The sample consisted of 86 undergraduate students: 45 females and 41 male. Respondents were asked to write down their reflections as a free text answering the question why did they make such a professional choice choosing Physics and Mathematics studies. Motives that influenced the choice of Physics and Mathematics mostly expressed the dimension of self-realization and the dimension of material achievements. It was also found that both personality and social-cultural factors were important in choosing Physics and Mathematics, i.e. sensation of vocation and professional aptitude, as well as encouragement of relatives and good evaluation of future profession’s status. There were also found differences in expression of motives and career barriers among male and female students.

  14. Choosing wisely: Review and commentary on anti-nuclear antibody (ANA) testing. (United States)

    Fritzler, Marvin J


    Choosing Wisely®: Next Steps in Improving Healthcare Value is an initiative of the American Board of Internal Medicine (ABIM) Foundation. The driving forces for the Choosing Wisely (CW) campaign include rising and unstainable health care expenditures and evidence that there is lack of fiscal stewardship of health care resources. The American College of Rheumatology and the Canadian Rheumatology Association published their top five Choosing Wisely recommendations, the first of which pertained to antinuclear antibodies (ANA) and ANA subserology testing. Concerns about the wasteful use of these tests prompted an analysis of the expenditures attributable to ANA testing as a proportion of total health care expenditures and based on a financial model was in the range of 0.00125%. It is suggested that if the sole use of ANA testing is to add evidence to support a diagnosis when the pre-test probability is high, then the ANA test has limited clinical value. Accordingly, the goal of ANA testing needs to be reconsidered and expanded beyond an approach to simply confirming a diagnosis with 'intention to treat' to a goal of case finding of 'pre- or early disease' with an 'intent to prevent' disease. This an area where more significant inroads can be made in preventing end organ disease and thereby reducing health care expenditures HCE. One CW recommendation that bears emphasizing is that, with a few possible exceptions, repeat ANA or ANA subserology testing has little clinical value in monitoring disease activity or predicting a flare.

  15. Sistem Penunjang Keputusan Pra Rancang Bangun Industri Intermediate Minyak Pala

    Directory of Open Access Journals (Sweden)

    Muhamad Malik Gunawan


    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 A lot of industries such as pharmacy, food industry, cosmetics industries use nurmeg oil for their products. Demand of nutmeg oil is very high its abaut 3-4% every year. Indonesia can export nutmeg oil up to 75 % world demands. Nutmeg oil which was expoted by Indonesia was crude nutmeg oil how ever some times have inconsistency quality. In order to produce nutmeg oil with better quality, nutmeg oil intermediate industry is needed. Decision support system is used to suggest the most potential process based on expert opinions. Methodology used was system approach and it was support with Analytical Hierarchy Process (AHP, Exponencial Comparison Method (MPE and financial feasibility analysis. The system was named SPKIMPA. This system consist four models there are selection model, election model, Institution model and financial feasibility model. From verification result it was know that the most potential process was fractionation. The intermediate industry is feasible to run with Net Present Value (NPV value Rp 426.627.432,83,- and Internal Rate Return (IRR value  45.28 %. Another result from verification system was created partnership with upperstream industry and also with downstream industry.

  16. Critical kinetic control of non-stoichiometric intermediate phase transformation for efficient perovskite solar cells (United States)

    Rong, Yaoguang; Venkatesan, Swaminathan; Guo, Rui; Wang, Yanan; Bao, Jiming; Li, Wenzhi; Fan, Zhiyong; Yao, Yan


    Organometal trihalide perovskites (OTP) have attracted significant attention as a low-cost and high-efficiency solar cell material. Due to the strong coordination between lead iodide (PbI2) and dimethyl sulfoxide (DMSO) solvent, a non-stoichiometric intermediate phase of MA2Pb3I8(DMSO)2 (MA = CH3NH3+) usually forms in the one-step deposition method that plays a critical role in attaining high power conversion efficiency. However, the kinetic understanding of how the non-stoichiometric intermediate phase transforms during thermal annealing is currently absent. In this work, we investigated such a phase transformation and provided a clear picture of three phase transition pathways as a function of annealing conditions. The interdiffusion of MAI and DMSO varies strongly with the annealing temperature and time, thus determining the final film composition and morphology. A surprising finding reveals that the best performing cells contain ~18% of the non-stoichiometric intermediate phase, instead of pure phase OTP. The presence of such an intermediate phase enables smooth surface morphology and enhances the charge carrier lifetime. Our results highlight the importance of the intermediate phase growth kinetics that could lead to large-scale production of efficient solution processed perovskite solar cells.Organometal trihalide perovskites (OTP) have attracted significant attention as a low-cost and high-efficiency solar cell material. Due to the strong coordination between lead iodide (PbI2) and dimethyl sulfoxide (DMSO) solvent, a non-stoichiometric intermediate phase of MA2Pb3I8(DMSO)2 (MA = CH3NH3+) usually forms in the one-step deposition method that plays a critical role in attaining high power conversion efficiency. However, the kinetic understanding of how the non-stoichiometric intermediate phase transforms during thermal annealing is currently absent. In this work, we investigated such a phase transformation and provided a clear picture of three phase transition

  17. Factors influencing a patient's decision to choose the type of treatment to improve dental esthetics

    Directory of Open Access Journals (Sweden)

    Gržić Renata


    Full Text Available Backgroung/Aim. Interest in dental esthetics has increased rapidly during the last few decades among both patients and dentists, and the creation of a natural dental appearance has become an important task in all fields of dentistry, especially in prosthodontics and restorative dentistry. The aim of this research was to investigate factors influencing a patient's decision to choose the type of treatment to improve dental esthetics. Methods. A total of 700 Caucasian subjects participated in the crosssectional study (261 men, 439 women, aged 18-86 years, mean age 46.2 ± 18.6. The study included clinical examination and a self-administrated questionnaire based on self-perceived esthetics, satisfaction with the appearance of their maxillary anterior teeth and previous dental experience. Multiple logistic regression was used in statistical analysis. Results. Hiding teeth during smile was the most important predictor for choosing fixed prosthetic restorations (OR 9.1, followed by self-perceived bad fixed prosthesis, malpositioned teeth and female gender (OR 2.9, 2.4, and 1.5, respectively. The increase in satisfaction with dental appearance and previous orthodontic therapy reduced chances for seeking prosthetic therapy (each OR 0.4. The significant predictors for bleaching choosing were hiding teeth during smiling, already done bleaching, female gender, lower levels of satisfaction with dental appearance and the absence of the previous orthodontic therapy (OR 5.8, 2.4, 1.8, 0.5 and 0.4, respecitively. Hiding teeth during smile, self-perceived malposition and crowding, and lower levels of satisfaction, were significant predictors for choosing orthodontic treatment (OR 3.1, 2.4, 2.2 and 0.6, respectively. None of current dental statuses was statistically significant predictor for choosing prosthodontic, bleeching nor orthodontic therapy. Conclusion. The psychological elements and female gender are the main predictors of seeking dental therapy

  18. Intermediate temperature solid oxide fuel cells. (United States)

    Brett, Daniel J L; Atkinson, Alan; Brandon, Nigel P; Skinner, Stephen J


    High temperature solid oxide fuel cells (SOFCs), typified by developers such as Siemens Westinghouse and Rolls-Royce, operate in the temperature region of 850-1000 degrees C. For such systems, very high efficiencies can be achieved from integration with gas turbines for large-scale stationary applications. However, high temperature operation means that the components of the stack need to be predominantly ceramic and high temperature metal alloys are needed for many balance-of-plant components. For smaller scale applications, where integration with a heat engine is not appropriate, there is a trend to move to lower temperatures of operation, into the so-called intermediate temperature (IT) range of 500-750 degrees C. This expands the choice of materials and stack geometries that can be used, offering reduced system cost and, in principle, reducing the corrosion rate of stack and system components. This review introduces the IT-SOFC and explains the advantages of operation in this temperature regime. The main advances made in materials chemistry that have made IT operation possible are described and some of the engineering issues and the new opportunities that reduced temperature operation affords are discussed. This tutorial review examines the advances being made in materials and engineering that are allowing solid oxide fuel cells to operate at lower temperature. The challenges and advantages of operating in the so-called 'intermediate temperature' range of 500-750 degrees C are discussed and the opportunities for applications not traditionally associated with solid oxide fuel cells are highlighted. This article serves as an introduction for scientists and engineers interested in intermediate temperature solid oxide fuel cells and the challenges and opportunities of reduced temperature operation.

  19. Intermediate Temperature Solid Oxide Fuel Cell Development

    Energy Technology Data Exchange (ETDEWEB)

    S. Elangovan; Scott Barnett; Sossina Haile


    Solid oxide fuel cells (SOFCs) are high efficiency energy conversion devices. Present materials set, using yttria stabilized zirconia (YSZ) electrolyte, limit the cell operating temperatures to 800 C or higher. It has become increasingly evident however that lowering the operating temperature would provide a more expeditious route to commercialization. The advantages of intermediate temperature (600 to 800 C) operation are related to both economic and materials issues. Lower operating temperature allows the use of low cost materials for the balance of plant and limits degradation arising from materials interactions. When the SOFC operating temperature is in the range of 600 to 700 C, it is also possible to partially reform hydrocarbon fuels within the stack providing additional system cost savings by reducing the air preheat heat-exchanger and blower size. The promise of Sr and Mg doped lanthanum gallate (LSGM) electrolyte materials, based on their high ionic conductivity and oxygen transference number at the intermediate temperature is well recognized. The focus of the present project was two-fold: (a) Identify a cell fabrication technique to achieve the benefits of lanthanum gallate material, and (b) Investigate alternative cathode materials that demonstrate low cathode polarization losses at the intermediate temperature. A porous matrix supported, thin film cell configuration was fabricated. The electrode material precursor was infiltrated into the porous matrix and the counter electrode was screen printed. Both anode and cathode infiltration produced high performance cells. Comparison of the two approaches showed that an infiltrated cathode cells may have advantages in high fuel utilization operations. Two new cathode materials were evaluated. Northwestern University investigated LSGM-ceria composite cathode while Caltech evaluated Ba-Sr-Co-Fe (BSCF) based pervoskite cathode. Both cathode materials showed lower polarization losses at temperatures as low as 600

  20. The intermediate age open cluster NGC 2660

    CERN Document Server

    Sandrelli, S; Tosi, M P; Marconi, G


    We present CCD UBVI photometry of the intermediate old open cluster NGC2660, covering from the red giants region to about seven magnitudes below the main sequence turn-off. Using the synthetic Colour - Magnitude Diagram method, we estimate in a self-consistent way values for distance modulus ((m-M)0 ~= 12.2), reddening (E(B-V) ~= 0.40), metallicity ([Fe/H] about solar), and age (age ~ 1 Gyr). A 30% population of binary stars turns out to be probably present.

  1. Observational constraints on dual intermediate inflation

    CERN Document Server

    Barrow, John D; Magueijo, João


    We explore the observational implications of models of intermediate inflation driven by modified dispersion relations, specifically those representing the phenomenon of dimensional reduction in the ultraviolet limit. These models are distinct from the standard ones because they do not require violations of the strong energy condition, and this is reflected in their structure formation properties. We find that they can naturally accommodate deviations from exact scale-invariance. They also make clear predictions for the running of the spectral index and tensor modes, rendering the models straightforwardly falsifiable. We discuss the observational prospects for these models and the implications these may have for quantum gravity scenarios.

  2. Thermoelectric power generator with intermediate loop (United States)

    Bell, Lon E; Crane, Douglas Todd


    A thermoelectric power generator is disclosed for use to generate electrical power from heat, typically waste heat. An intermediate heat transfer loop forms a part of the system to permit added control and adjustability in the system. This allows the thermoelectric power generator to more effectively and efficiently generate power in the face of dynamically varying temperatures and heat flux conditions, such as where the heat source is the exhaust of an automobile, or any other heat source with dynamic temperature and heat flux conditions.

  3. Organophosphate poisoning: Diagnosis of intermediate syndrome

    Directory of Open Access Journals (Sweden)

    Poojara L


    Full Text Available Organophosphate compound (OPC poisoning with suicidal intent is common in Indian ICUs. The effect of OPCs is to produce a persistent depolarization of the neuromuscular junction leading to muscle weakness. After initial recovery from cholinergic crisis, some patients have resurgence of respiratory muscle paralysis requiring continued ventilatory support. This is termed intermediate syndrome (IMS. This could be due to a change in the type of neuromuscular block to a non depolarisation block characterized by a fade on tetanic stimulation. However peripheral nerve stimulation using train-of-four ratio (TOF and/tetanus have failed to consistently show such a change. We elected to study whether electro physiological monitoring using repetitive nerve stimulation might show a decremental response during IMS. Material & Methods: This was a prospective blinded study done from April 2002 to March 2003 in our ICU. 45 consecutive patients of OPC poisoning admitted during this period were included in this study. Repetitive nerve stimulation (RNS using a train of ten at 3Hz 10Hz and 30Hz (slow , intermediate and fast speeds respectively at the median nerve was done on all patients on day 1, 4, 7 and every 4th day thereafter until discharge. Patients were ventilated until ready to wean as per our usual protocol. The results of the RNS study were not revealed to the intensivist. Results: 9 out of 45 patients required ventilation for more than 6 days and showed overt signs of intermediate syndrome - proximal muscle weakness, twitching and respiratory weakness. Only 2 patients out of the 9 had a decremental response on RNS at 3Hz indicating a post-junctional dysfunction at the motor end-plate, Both patients had consumed a very large quantity of OPC and were deeply comatose for >4 days and required ventilation for >12 days. All other patients with IMS showed no changes on RNS. The exact type of poison consumed varied with each individual patient. Conclusion: RNS

  4. q-Gamow States for intermediate energies

    CERN Document Server

    Plastino, A; Zamora, D J


    In a recent paper [Nuc. Phys. A {\\bf 948}, (2016) 19] we have demonstrated the possible existence of Tsallis' q-Gamow states. Now, accelerators' experimental evidence for Tsallis' distributions has been ascertained only at very high energies. Here, instead, we develop a different set of q-Gamow states for which the associated q-Breit-Wigner distribution could easily be found at intermediate energies, for which accelerators are available at many locations. In this context, it should be strongly emphasized [Physica A {\\bf 388} (2009) 601] that, empirically, one never exactly and unambiguously "detects" pure Gaussians, but rather q-Gaussians. A prediction is made via Eq.(3.30)

  5. Intermediate Bandgap Solar Cells From Nanostructured Silicon

    Energy Technology Data Exchange (ETDEWEB)

    Black, Marcie [Bandgap Engineering, Lincoln, MA (United States)


    This project aimed to demonstrate increased electronic coupling in silicon nanostructures relative to bulk silicon for the purpose of making high efficiency intermediate bandgap solar cells using silicon. To this end, we formed nanowires with controlled crystallographic orientation, small diameter, <111> sidewall faceting, and passivated surfaces to modify the electronic band structure in silicon by breaking down the symmetry of the crystal lattice. We grew and tested these silicon nanowires with <110>-growth axes, which is an orientation that should produce the coupling enhancement.

  6. Opening the Black Box of Intermediation

    DEFF Research Database (Denmark)

    Nowinska, Agnieszka

    ) and at the interfirm level (between partners and within alliances and associations).The tentative results show that both of these levels are important in defining the intermediating firms' business models and in answering their environmental threats and in building up competitive advantage. The paper ends with a short...... dynamics. This paper draws on qualitative data originating with interviews with industry representatives and can also be regarded as a preliminary approach to a broader project. The analysis distinguishes between relational capital at the intrafirm level (the network among the company's employees...

  7. Derivation of validated methods of sampling and analysis for intermediate and final products of the anaerobic material utilization of volatile chlorinated hydrocarbons (LCFC) in groundwater in the context of analyses of contaminated soils; Ableitung validierter Probenahme- und Analysenmethoden fuer Zwischen- und Endprodukte der anaeroben Stoffverwertungsprozesse von Leichtfluechtigen Chlorierten Kohlenwasserstoffen (LCKW) im Grundwasser im Rahmen von Altlastenuntersuchungen

    Energy Technology Data Exchange (ETDEWEB)

    Dorgerloh, Ute; Becker, Roland; Win, Tin [Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin (Germany); Theissen, Hubert [IMAGO GbR (Germany)


    The results of the project ''Methods of sampling and analysis of intermediate and final products of the anaerobic degradation of volatile halogenated hydrocarbons in groundwater in frame of analysis of contaminated sites'' of the German Federal States Program ''Water, Soil, Waste'' (Laenderfinanzierungsprogramm ''Wasser, Boden, Luft'') LFP B2.08 are presented in these report. Different methods of sampling and analysis for the determination of hydrogen, methane, ethene and vinyl chloride in groundwater are developed and validated: For the sampling are described and discussed: i. active sampling: purge and sample of water samples and purging of solvated gases in groundwater in gas sampling tubes ii. passive sampling: diffusion sampling in polyethylene diffusion bags (PDB) and plastic syringes as diffusion sampler for solvated gases The use of active (purge and sample, downhole sampler) and passive (diffusion sampling) sampling techniques for the quantification of VOC, ethene, and methane are evaluated from the viewpoint of public authorities and regarding the reproducibility of measurement results. Based on a groundwater contaminated with trichloroethene, 1,2-dichloroethene, and vinyl chloride it is shown that passive sampling is restricted by low groundwater flow and biological activity inside the well casing. Therefore, active sampling is to be preferred in case of unknown or insufficient flow conditions in the aquifer. The methods of chromatography for the determination of the compounds are validated and compared with other appropriate analytical methods: I. Headspace-GC-FID for the determination of methane, ethene and vinyl chloride in water of the purged sample (i) and the water of the PDB (ii) II. Direct injection - GC-PDD for the determination of hydrogen from the collected gas samples of the gas sampling tube (i) and the plastic syringes (ii) The gas chromatographic procedure for vinyl chloride using

  8. Intermediate Mass Stars <--> Massive Stars. A workshop around causes and consequences of differing evolutionary paths

    CERN Document Server

    Josselin, Eric


    The post-main sequence evolution of stars of intermediate or large masses is notoriously complex. In the recent past, a number of workshops and meetings have focused on either the Asymptotic Giant Branch of intermediate mass stars, or the evolution of massive stars. But how well defined is the boundary between these categories of objects defined? How would an observer proceed to classify stars into one or the other category? How do objects near the boundary evolve, die, and contribute to the chemical evolution of their environment? During this 3-day international workshop, 26 high quality presentations were given by specialists in the relevant fields of astrophysics, and stimulating discussions followed. It is technically impossible to provide an exhaustive census of the results and ideas that emerged. In this brief article, we choose to point to key elements of the workshop, some of which are now the topic of new collaborations and will lead to publications elsewhere. For the sake of brevity, we deliberately...

  9. Role of near threshold resonances in intermediate energy nuclear physics

    Indian Academy of Sciences (India)

    B K Jain; N J Upadhyay


    The presence of a resonance close to the threshold strongly effects the dynamics of the interacting particles at low energies. Production of 12C, the element for life, in 4He burning in Sun is a classic example of such a situation. In intermediate energy nuclear physics, this situation arises in the interactions of an -meson with a nucleon and that of a −-meson with a proton at low energies, where both these systems have a resonance or a bound state near their thresholds, resulting in a strong attractive interaction. If putting these mesons in nuclear environment produces a strong attraction, it is possible that, in nature there may exist - and −-nuclear bound states. Such a tantalizing possibility has led to experimental and theoretical programmes to search for them. These efforts have produced positive results. This paper gives a brief critical overview of these studies, emphasizing especially the efforts led by Bhabha Atomic Research Centre (BARC).

  10. Photodissociation dynamics and spectroscopy of free radical combustion intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Osborn, D.L.


    The photodissociation spectroscopy and dynamics of free radicals is studied by the technique of fast beam photofragment translational spectroscopy. Photodetachment of internally cold, mass-selected negative ions produces a clean source of radicals, which are subsequently dissociated and detected. The photofragment yield as a function of photon energy is obtained, mapping out the dissociative and predissociative electronic states of the radical. In addition, the photodissociation dynamics, product branching ratios, and bond energies are probed at fixed photon energies by measuring the translational energy, P(E{sub T}), and angular distribution of the recoiling fragments using a time- and position-sensitive detector. Ab initio calculations are combined with dynamical and statistical models to interpret the observed data. The photodissociation of three prototypical hydrocarbon combustion intermediates forms the core of this work.

  11. Photodissociation dynamics and spectroscopy of free radical combustion intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Osborn, David Lewis [Univ. of California, Berkeley, CA (United States)


    The photodissociation spectroscopy and dynamics of free radicals is studied by the technique of fast beam photofragment translational spectroscopy. Photodetachment of internally cold, mass-selected negative ions produces a clean source of radicals, which are subsequently dissociated and detected. The photofragment yield as a function of photon energy is obtained, mapping out the dissociative and predissociative electronic states of the radical. In addition, the photodissociation dynamics, product branching ratios, and bond energies are probed at fixed photon energies by measuring the translational energy, P(ET), and angular distribution of the recoiling fragments using a time- and position-sensitive detector. Ab initio calculations are combined with dynamical and statistical models to interpret the observed data. The photodissociation of three prototypical hydrocarbon combustion intermediates forms the core of this work.

  12. 49 CFR 37.201 - Intermediate and rest stops. (United States)


    ... 49 Transportation 1 2010-10-01 2010-10-01 false Intermediate and rest stops. 37.201 Section 37.201... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.201 Intermediate and rest stops. (a) Whenever an OTRB makes an intermediate or rest stop, a passenger with a disability, including an individual using...

  13. Surface Intermediate Zone of Submerged Turbulent Buoyant Jet in Current

    DEFF Research Database (Denmark)

    Chen, H. B.; Larsen, Torben


    This paper deals with the intermediate zone between the jet and plume stages of a submerged buoyant discharge from sea outfall in current. The stability criteria, plume width and height after the intermediate zone and the dilution within the intermediate region have been studied theoretically...

  14. Anomalous hydrocracking of triglycerides over CoMo-catalyst-influence of reaction intermediates

    Indian Academy of Sciences (India)

    M Anand; M G Sibi; D Verma; A K Sinha


    Reaction intermediates have been identified and followed to understand anomalous cracking of jathropha oil triglycerides in the presence of sulphided Co-Mo/Al2O3 catalyst. Undesirable C-C coupling reactions are favoured at temperatures between 320° and 340°C, giving waxy oligomerization products, whereas at temperatures above 340°C, direct hydrocracking of triglycerides to lighter and middle distillates were favoured. To minimize undesirable waxy oligomerization products, higher pressures (>80 bar) and higher H2/feed ratios (>1500) were necessary. Aldol condensation and ketonization reactions between the reaction intermediates are counter-productive as they result in waxy long chain oxygenated products which tend to accumulate on the catalyst surface, choke the reactor and cause rapid catalyst deactivation. Reaction conditions have to be optimized to minimize condensation reaction during this process.

  15. Financial Intermediation, Monetary Uncertainty, and Bank Interest Margins Financial Intermediation, Monetary Uncertainty, and Bank Interest Margins

    Directory of Open Access Journals (Sweden)

    Leonardo Hernández


    Full Text Available Financial Intermediation, Monetary Uncertainty, and Bank Interest Margins This paper studies a simple model of financial intermediation in order to understand how the lending-borrowing spread or interest margin charged by financial intermediaries is determined in equilibrium in a monetary economy. The main conclusion of the paper concerns the effect on the spread of changes in the distribution of monetary innovations. Thus, changes in the monetary-policy-rule followed by the Central Bank which alter the volatility of inflation will have important effects on the interest margin and also on the amount of credit available to investors. A crosssection empirical analysis strongly supports our hypothesis:

  16. Fission in intermediate energy heavy ion reactions

    Energy Technology Data Exchange (ETDEWEB)

    Wilhelmy, J.B.; Begemann-Blaich, M.; Blaich, T.; Boissevain, J.; Fowler, M.M.; Gavron, A.; Jacak, B.V.; Lysaght, P.S. (Los Alamos National Lab., NM (USA)); Britt, H.C.; Fields, D.J.; Hansen, L.F.; Lanier, R.G.; Massoletti, D.J.; Namboodiri, M.M.; Remington, B.A.; Sangster, T.C.; Struble, G.L.; Webb, M.L. (Lawrence Livermore National Lab., CA (USA)); Chan, Y.D.; Dacai, A.; Harmon, A.; Leyba, J.; Pouliot, J.; Stokstad, R.G. (Lawrence Berkeley Lab., CA (USA)); Hansen, O.; Levine, M.J.; Thorn, C.E.; Trautmann, W. (Brookhaven National Lab., Upton, NY (USA)); Dichter, B.; Kaufman, S.; Videbaek, F. (Argonne National Lab. (USA)); Fraenkel, Z.; Mamane, G. (Weizmann Inst. of Science, Rehovoth (Israel)); Cebra, D.; Westfall, G.D. (Michigan State Univ., East Lansing (USA))


    A systematic study of reaction mechanisms at intermediate energies (50-100 MeV/A) has been performed at the Lawrence Berkeley Laboratory's BeValac using medium weight projectiles on medium and heavy element targets. A gas and plastic phoswich detector system was employed which gave large geometric coverage and a wide dynamic response. The particles identified with the gas detectors could be characterized into three components - intermediate mass fragments (IMF), fission fragments (FF) and heavy residues (HR). Major observed features are: The reaction yields are similar in the 50 to 100 MeV/A range, central collisions have high multiplicty of IMF's with broad angular correlations consistent with a large participant region, effects of final state Coulomb interactions are observed and give information on the size and temporal behavior of the source, true fission yields are dependent on target fissility and correlated with relatively peripheral collisions. Analysis of fission and evaporation yields implies limiting conditions for which fission decay remains a viable deexcitation channel. (orig.).

  17. Keto-Enol Thermodynamics of Breslow Intermediates. (United States)

    Paul, Mathias; Breugst, Martin; Neudörfl, Jörg-Martin; Sunoj, Raghavan B; Berkessel, Albrecht


    Breslow intermediates, first postulated in 1958, are pivotal intermediates in carbene-catalyzed umpolung. Attempts to isolate and characterize these fleeting amino enol species first met with success in 2012 when we found that saturated bis-Dipp/Mes imidazolidinylidenes readily form isolable, though reactive diamino enols with aldehydes and enals. In contrast, triazolylidenes, upon stoichiometric reaction with aldehydes, gave exclusively the keto tautomer, and no isolable enol. Herein, we present the synthesis of the "missing" keto tautomers of imidazolidinylidene-derived diamino enols, and computational thermodynamic data for 15 enol-ketone pairs derived from various carbenes/aldehydes. Electron-withdrawing substituents on the aldehyde favor enol formation, the same holds for N,N'-Dipp [2,6-di(2-propyl)phenyl] and N,N'-Mes [2,4,6-trimethylphenyl] substitution on the carbene component. The latter effect rests on stabilization of the diamino enol tautomer by Dipp substitution, and could be attributed to dispersive interaction of the 2-propyl groups with the enol moiety. For three enol-ketone pairs, equilibration of the thermodynamically disfavored tautomer was attempted with acids and bases but could not be effected, indicating kinetic inhibition of proton transfer.

  18. Intermediate energy neutron beams from the MURR. (United States)

    Brugger, R M; Herleth, W H


    Several reactors in the United States are potential candidates to deliver beams of intermediate energy neutrons for NCT. At this time, moderators, as compared to filters, appear to be the more effective means of tailoring the flux of these reactors. The objective is to sufficiently reduce the flux of fast neutrons while producing enough intermediate energy neutrons for treatments. At the University of Missouri Research Reactor (MURR), the code MCNP has recently been used to calculate doses in a phantom. First, "ideal" beams of 1, 35, and 1000 eV neutrons were analyzed to determine doses and advantage depths in the phantom. Second, a high quality beam that had been designed to fit in the thermal column of the MURR, was reanalyzed. MCNP calculations of the dose in phantom in this beam confirmed previous calculations and showed that this beam would be a nearly ideal one with neutrons of the desired energy and also a high neutron current. However, installation of this beam will require a significant modification of the thermal column of the MURR. Therefore, a second beam that is less difficult to build and install, but of lower neutron current, has been designed to fit in MURR port F. This beam is designed using inexpensive A1, S, and Pb. The doses calculated in the phantom placed in this beam show that it will be satisfactory for sample tests, animal tests, and possible initial patient trials. Producing this beam will require only modest modifications of the existing tube.

  19. Intermediate Mass Fragment Emission Pattern in Peripheral Heavy-Ion Collisions at Fermi Energies (United States)

    Piantelli, S.; Bidini, L.; Poggi, G.; Bini, M.; Casini, G.; Maurenzig, P. R.; Olmi, A.; Pasquali, G.; Stefanini, A. A.; Taccetti, N.


    The emission pattern in the vperp-vpar plane of intermediate mass fragments with Z = 3-7 (IMF) has been studied in the collision 116Sn+ 93Nb at 29.5A MeV as a function of the total kinetic energy loss of the reaction. This pattern shows that for peripheral reactions most IMF's are emitted at velocities intermediate between those of the projectile- and target-like products. Coulomb trajectory calculations show that these IMF's are produced in the interaction zone in a short time interval at the end of the target-projectile interaction.

  20. Validation of Geant4 hadronic physics models at intermediate energies (United States)

    Banerjee, Sunanda; Geant4 Hadronic Group


    GEANT4 provides a number of physics models at intermediate energies (corresponding to incident momenta in the range 1-20 GeV/c). Recently, these models have been validated with existing data from a number of experiments: (a) inclusive proton and neutron production with a variety of beams (π-, π+, p) at different energies between 1 and 9 GeV/c on a number of nuclear targets (from beryllium to uranium); (2) inclusive pion/kaon/proton production from 14.6 GeV/c proton beams on nuclear targets (from beryllium to gold); (3) inclusive pion production from pion beams between 3-13 GeV/c on a number of nuclear targets (from beryllium to lead). The results of simulation/data comparison for different GEANT4 models are discussed in the context of validating the models and determining their usage in physics lists for high energy application. Due to the increasing number of validations becoming available, and the requirement that they be done at regular intervals corresponding to the GEANT4 release schedule, automated methods of validation are being developed.

  1. Why do some males choose to breed at home when most other males disperse? (United States)

    Davidian, Eve; Courtiol, Alexandre; Wachter, Bettina; Hofer, Heribert; Höner, Oliver P.


    Dispersal is a key driver of ecological and evolutionary processes. Despite substantial efforts to explain the evolution of dispersal, we still do not fully understand why individuals of the same sex of a species vary in their propensity to disperse. The dominant hypothesis emphasizes movements and assumes that leaving home (dispersal) and staying at home (philopatry) are two alternative strategies providing different fitness. It suggests that only individuals of high phenotypic quality can pursue the most beneficial strategy; the others are left to do a “best-of-a-bad” job. An alternative hypothesis emphasizes settlement decisions and suggests that all individuals pursue a single strategy of choosing the breeding habitat or group with the highest fitness prospects; choosing the natal group (philopatry) and choosing a nonnatal group (dispersal) are then outcomes of these decisions. We tested both hypotheses using a long-term study of a free-ranging population of a group-living carnivore, the spotted hyena. We combined demographic data with data on dispersal-relevant phenotypic traits, breeding-group choice, survival, and reproductive success of 254 males. Our results contradict the best-of-a-bad-job hypothesis: philopatric males and dispersers were of similar phenotypic quality, had similar fitness, and applied similar settlement rules based on the fitness prospects in groups. Our findings demonstrate that the distribution of breeding partners can be more important in shaping dispersal patterns than the costs associated with the dispersal movement. The study provides novel insights into the processes leading to the coexistence of philopatry and dispersal within the same sex of a species. PMID:27034982

  2. Health-related restrictions of choices and choosing: implications for quality of life and clinical interventions

    Directory of Open Access Journals (Sweden)

    Barry J Gurland


    Full Text Available Barry J Gurland1, Huai Cheng2, Mathew S Maurer31Columbia University Department of Psychiatry, Stroud Center for Study of Quality of Life, New York, NY, USA; 2Anderson Cancer Center, Houston, TX, USA; 3Columbia Presbyterian Medical Center, New York, NY, USABackground: The process of “accessing choices and choosing among them” (c-c has been proposed as a model for understanding, evaluating, and assisting a patient’s management of quality of life. If desired choices are freely accessible, and the act of choosing is efficient and unconstrained, then the outcome is optimized quality of life. The c-c model fits many clinical situations where improved quality of life is a goal, and interventions may be aimed at relieving health-related restrictions of the patient’s desired activities. Aims: To determine the impact of health restrictions of choices and choosing on indicators and outcomes reflecting quality of life. Method: Secondary analysis of a community-based health survey of three ethnic groups, 65 years and older (n = 2,130, repeated after 18 months, with mortality over 6 years. Findings: Complaints of health restrictions of desired activities accounted for about half the variance of all determinants of a quality of life proxy indicator, and had a high frequency. Such complaints also predicted declines in mood and function, higher death rates, and increased service use.Conclusions: Clinical trials are warranted of the efficacy for quality of life improvement of interventions that focus on the relief of health-induced restrictions of desired activities.Keywords: choice, quality of life, aging, health restrictions

  3. Decision and experience: why don't we choose what makes us happy? (United States)

    Hsee, Christopher K; Hastie, Reid


    Recent years have witnessed a growing interest among psychologists and other social scientists in subjective well-being and happiness. Here we review selected contributions to this development from the literature on behavioral-decision theory. In particular, we examine many, somewhat surprising, findings that show people systematically fail to predict or choose what maximizes their happiness, and we look at reasons why they fail to do so. These findings challenge a fundamental assumption that underlies popular support for consumer sovereignty and other forms of autonomy in decision-making (e.g. marriage choice), namely, the assumption that people are able to make choices in their own best interests.

  4. What Do You Think Would Make You Happier? What Do You Think You Would Choose?* (United States)

    Benjamin, Daniel J.; Kimball, Miles S.; Heffetz, Ori; Rees-Jones, Alex


    Would people choose what they think would maximize their subjective well-being (SWB)? We present survey respondents with hypothetical scenarios and elicit both choice and predicted SWB rankings of two alternatives. While choice and predicted SWB rankings usually coincide in our data, we find systematic reversals. We identify factors—such as predicted sense of purpose, control over one’s life, family happiness, and social status—that help explain hypothetical choice controlling for predicted SWB. We explore how our findings vary by SWB measure and by scenario. Our results have implications regarding the use of SWB survey questions as a proxy for utility. PMID:23275649

  5. Choosing to be happy? Age differences in 'maximizing' decision strategies and experienced emotional well-being


    Bruine de Bruin, W; Parker, A; Strough, J


    Maximizing is a decision strategy that seeks the very best option, which is more elaborate and potentially more regret-inducing than choosing an option that is ‘good enough.’ In surveys with a large national sample, we find that older adults are less likely than younger adults to self-report maximizing, which is associated with their better experienced well-being reported two years later. This pattern holds after controlling for demographic characteristics and negative life events. Our findin...

  6. How prevalent and costly are Choosing Wisely low-value services? Evidence from Medicare beneficiaries. (United States)

    Collado, Megan


    (1) Through the Choosing Wisely initiative, medical specialty societies identified non-indicated cardiac testing in low-risk patients and short-interval dual-energy X-ray absorptiometry (DXA) or bone density testing as low-value care. (2) Nationally, 13 percent of low-risk Medicare beneficiaries received non-indicated cardiac tests, and 10 percent of DXAs reimbursed by Medicare were administered at inappropriately short intervals. There is significant geographic variation in the provision of these services. (2) Carefully designed policy and payment changes will likely prove most effective in reducing low-value care.

  7. Method of Choosing the Information Technology System Supporting Management of the Military Aircraft Operation

    Directory of Open Access Journals (Sweden)

    Barszcz Piotr


    Full Text Available The paper presents a method of choosing the information technology system, the task of which is to support the management process of the military aircraft operation. The proposed method is based on surveys conducted among direct users of IT systems used in aviation of the Polish Armed Forces. The analysis of results of the surveys was conducted using statistical methods. The paper was completed with practical conclusions related to further usefulness of the individual information technology systems. In the future, they can be extremely useful in the process of selecting the best solutions and integration of the information technology systems

  8. Choosing Open Source ERP Systems: What Reasons Are There For Doing So? (United States)

    Johansson, Björn; Sudzina, Frantisek

    Enterprise resource planning (ERP) systems attract a high attention and open source software does it as well. The question is then if, and if so, when do open source ERP systems take off. The paper describes the status of open source ERP systems. Based on literature review of ERP system selection criteria based on Web of Science articles, it discusses reported reasons for choosing open source or proprietary ERP systems. Last but not least, the article presents some conclusions that could act as input for future research. The paper aims at building up a foundation for the basic question: What are the reasons for an organization to adopt open source ERP systems.

  9. Outsourcing your medical practice call center: how to choose a vendor to ensure regulatory compliance. (United States)

    Johnson, Bill


    Medical practices receive hundreds if not thousands of calls every week from patients, payers, pharmacies, and others. Outsourcing call centers can be a smart move to improve efficiency, lower costs, improve customer care, ensure proper payer management, and ensure regulatory compliance. This article discusses how to know when it's time to move to an outsourced call center, the benefits of making the move, how to choose the right call center, and how to make the transition. It also provides tips on how to manage the call center to ensure the objectives are being met.

  10. Thermogravimetric control of intermediate compounds in uranium metallurgy; Control termogravimetrico de productos intermedios de la metalurgia del uranio

    Energy Technology Data Exchange (ETDEWEB)

    Gasco Sanchez, L.; Fernandez Cellini, R.


    The thermal decomposition of some intermediate compounds in the metallurgy of the uranium as uranium peroxide, ammonium uranate, uranium and ammonium penta-fluoride, uranium tetrafluoride and uranous oxide has been study by means of the Chevenard's thermo balance. Some data on pyrolysis of synthetic mixtures of intermediate compounds which may occasionally appear during the industrial process, are given. Thermogravimetric methods of control are suggested, usable in interesting products in the uranium metallurgy. (Author) 20 refs.

  11. Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

    Directory of Open Access Journals (Sweden)

    Yaming Jiu


    Full Text Available The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive. Here, we find that specific actin stress fiber structures, transverse arcs, interact with vimentin intermediate filaments and promote their retrograde flow. Consequently, myosin-II-containing arcs are important for perinuclear localization of the vimentin network in cells. The vimentin network reciprocally restricts retrograde movement of arcs and hence controls the width of flat lamellum at the leading edge of the cell. Depletion of plectin recapitulates the vimentin organization phenotype of arc-deficient cells without affecting the integrity of vimentin filaments or stress fibers, demonstrating that this cytoskeletal cross-linker is required for productive interactions between vimentin and arcs. Collectively, our results reveal that plectin-mediated interplay between contractile actomyosin arcs and vimentin intermediate filaments controls the localization and dynamics of these two cytoskeletal systems and is consequently important for cell morphogenesis.

  12. Picornavirus uncoating intermediate captured in atomic detail (United States)

    Ren, Jingshan; Wang, Xiangxi; Hu, Zhongyu; Gao, Qiang; Sun, Yao; Li, Xuemei; Porta, Claudine; Walter, Thomas S.; Gilbert, Robert J.; Zhao, Yuguang; Axford, Danny; Williams, Mark; McAuley, Katherine; Rowlands, David J.; Yin, Weidong; Wang, Junzhi; Stuart, David I.; Rao, Zihe; Fry, Elizabeth E.


    It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into the host cell. Picornaviruses are simple models for such viruses, and initiate this uncoating process through particle expansion, which reveals channels through which internal capsid proteins and the viral genome presumably exit the particle, although this has not been clearly seen until now. Here we present the atomic structure of an uncoating intermediate for the major human picornavirus pathogen CAV16, which reveals VP1 partly extruded from the capsid, poised to embed in the host membrane. Together with previous low-resolution results, we are able to propose a detailed hypothesis for the ordered egress of the internal proteins, using two distinct sets of channels through the capsid, and suggest a structural link to the condensed RNA within the particle, which may be involved in triggering RNA release. PMID:23728514

  13. Simulations of Oligomeric Intermediates in Prion Diseases

    CERN Document Server

    Mobley, D L; Singh, R R P; Kulkarni, R V; Slepoy, A; Mobley, David L.; Cox, Daniel L.; Singh, Rajiv R. P.; Kulkarni, Rahul V.; Slepoy, Alexander


    We extend our previous stochastic cellular automata based model for areal aggregation of prion proteins on neuronal surfaces. The new anisotropic model allow us to simulate both strong beta-sheet and weaker attachment bonds between proteins. Constraining binding directions allows us to generate aggregate structures with the hexagonal lattice symmetry found in recently observed in vitro experiments. We argue that these constraints on rules may correspond to underlying steric constraints on the aggregation process. We find that monomer dominated growth of the areal aggregate is too slow to account for some observed doubling time-to-incubation time ratios inferred from data, and so consider aggregation dominated by relatively stable but non-infectious oligomeric intermediates. We compare a kinetic theory analysis of oligomeric aggregation to spatially explicit simulations of the process. We find that with suitable rules for misfolding of oligomers, possibly due to water exclusion by the surrounding aggregate, th...

  14. Flow angle from intermediate mass fragment measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rami, F.; Crochet, P.; Dona, R.; De Schauenburg, B.; Wagner, P.; Alard, J.P.; Andronic, A.; Basrak, Z.; Bastid, N.; Belyaev, I.; Bendarag, A.; Berek, G.; Best, D.; Caplar, R.; Devismes, A.; Dupieux, P.; Dzelalija, M.; Eskef, M.; Fodor, Z.; Gobbi, A.; Grishkin, Y.; Herrmann, N.; Hildenbrand, K.D.; Hong, B.; Kecskemeti, J.; Kirejczyk, M.; Korolija, M.; Kotte, R.; Lebedev, A.; Leifels, Y.; Merlitz, H.; Mohren, S.; Moisa, D.; Neubert, W.; Pelte, D.; Petrovici, M.; Pinkenburg, C.; Plettner, C.; Reisdorf, W.; Schuell, D.; Seres, Z.; Sikora, B.; Simion, V.; Siwek-Wilczynska, K.; Stoicea, G.; Stockmeir, M.; Vasiliev, M.; Wisniewski, K.; Wohlfarth, D.; Yushmanov, I.; Zhilin, A


    Directed sideward flow of light charged particles and intermediate mass fragments was measured in different symmetric reactions at bombarding energies from 90 to 800 A MeV. The flow parameter is found to increase with the charge of the detected fragment up to Z = 3-4 and then turns into saturation for heavier fragments. Guided by simple simulations of an anisotropic expanding thermal source, we show that the value at saturation can provide a good estimate of the flow angle, {theta}{sub flow}, in the participant region. It is found that {theta}{sub flow} depends strongly on the impact parameter. The excitation function of {theta}{sub flow} reveals striking deviations from the ideal hydrodynamical scaling. The data exhibit a steep rise of {theta}{sub flow} to a maximum at around 250 - 400 A MeV, followed by a moderate decrease as the bombarding energy increases further.

  15. Turned Back: Mad Men as Intermedial Melodrama

    Directory of Open Access Journals (Sweden)

    Monique Rooney


    Full Text Available This essay draws on definitions of gesture (Giorgio Agamben and Peter Brooks and catachresis (Peter Brooks, Jacques Derrida to examine the primacy of non-verbal signifiers as communicators of meaning in AMC’s Mad Men. Beginning with an analysis of Mad Men’s credit sequence, it draws attention to Mad Men’s use of gesture and catachresis in relation to melodrama’s privileging of non-verbal and naturalistic expression and its persistence as an intermedial mode that has moved back and forth between various media (theatre, novel, cinema, television and now digital formats. It argues that Mad Men’s melodramatic aesthetic is one that obliquely, and via a gestural and rhetorical ‘turned back’, communicates its relation to the past and the present.

  16. Intermediate Care Unit - defining substituyable admissions

    DEFF Research Database (Denmark)

    Nygaard, Hanne; Ekmann, Anette Addy

    Background: Elderly patients have excess risk of functional decline and development of delirium. Studies have shown that 14-27 % of hospitalizations among elderly patients are substitutable. To lower the risk of unwanted consequences of hospitalizations, we implemented an Intermediate Care Unit...... (TUE). TUE was established in collaboration between Bispebjerg Hospital and the City of Copenhagen and took in patients whose hospitalization was regarded as substitutable. TUE offered a quick diagnostic assessment by a cross sectoral team of hospital doctors and community nurses. Home care was offered...... Care Unit.' Methods: From September 17, 2012 - June 24, 2014, 969 patients were treated at TUE. We registered both demographic-, treatment- and medical data and furthermore functional related variables. We used logistic regression to test the association between a combined graded variable of EWS...

  17. Fission dynamics with systems of intermediate fissility

    Indian Academy of Sciences (India)

    E Vardaci; A Di Nitto; P N Nadtochy; A Brondi; G La Rana; R Moro; M Cinausero; G Prete; N Gelli; E M Kozulin; G N Knyazheva; I M Itkis


    A 4 light charged particle spectrometer, called 8 LP, is in operation at the Laboratori Nazionali di Legnaro, Italy, for studying reaction mechanisms in low-energy heavy-ion reactions. Besides about 300 telescopes to detect light charged particles, the spectrometer is also equipped with an anular PPAC system to detect evaporation residues and a two-arm time-of-flight spectrometer to detect fission fragments. The spectrometer has been used in several fission dynamics studies using as a probe light charged particles in the fission and evaporation residues (ER) channels. This paper proposes a journey within some open questions about the fission dynamics and a review of the main results concerning nuclear dissipation and fission time-scale obtained from several of these studies. In particular, the advantages of using systems of intermediate fissility will be discussed.

  18. [Intermediate care units and noninvasive ventilation]. (United States)

    Becker, Heinrich F; Schönhofer, Bernd; Vogelmeier, Claus


    Intermediate care units (IMC) have been introduced to provide optimal patient management according to disease severity and to bridge the gap between intensive care (ICU) and general wards. Most patients that are referred to an IMC need monitoring and intensive analgetic treatment. Over the past years noninvasive ventilation (NIV) and weaning have emerged as important new forms of active treatment in the IMC. Most studies that have been published so far demonstrate that an IMC improves patient outcome and lowers costs, although randomized controlled trials are missing. NIV reduces mortality, the need for intubation as well as ICU and hospital length of stay in patients with chronic obstructive pulmonary disease (COPD) and other disorders that cause respiratory failure. In many cases NIV can be performed in the IMC, a fact that reduces the number of ICU admissions, lowers costs and improves patient care. The high prevalence of pulmonary diseases and NIV emphasizes the importance of pneumologists as directors of both ICU and IMC.

  19. Precalibrating an intermediate complexity climate model

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Neil R. [The Open University, Earth and Environmental Sciences, Milton Keynes (United Kingdom); Cameron, David [Centre for Ecology and Hydrology, Edinburgh (United Kingdom); Rougier, Jonathan [University of Bristol, Department of Mathematics, Bristol (United Kingdom)


    Credible climate predictions require a rational quantification of uncertainty, but full Bayesian calibration requires detailed estimates of prior probability distributions and covariances, which are difficult to obtain in practice. We describe a simplified procedure, termed precalibration, which provides an approximate quantification of uncertainty in climate prediction, and requires only that uncontroversially implausible values of certain inputs and outputs are identified. The method is applied to intermediate-complexity model simulations of the Atlantic meridional overturning circulation (AMOC) and confirms the existence of a cliff-edge catastrophe in freshwater-forcing input space. When uncertainty in 14 further parameters is taken into account, an implausible, AMOC-off, region remains as a robust feature of the model dynamics, but its location is found to depend strongly on values of the other parameters. (orig.)

  20. Melting of metallic intermediate level waste

    Energy Technology Data Exchange (ETDEWEB)

    Huutoniemi, Tommi; Larsson, Arne; Blank, Eva [Studsvik Nuclear AB, Nykoeping (Sweden)


    This report presents a feasibility study of a melting facility for core components and reactor internals. An overview is given of how such a facility for treatment of intermediate level waste might be designed, constructed and operated and highlights both the possibilities and challenges. A cost estimate and a risk analysis are presented in order to make a conclusion of the technical feasibility of such a facility. Based on the authors' experience in operating a low level waste melting facility, their conclusion is that without technical improvements such a facility is not feasible today. This is based on the cost of constructing and operating such a facility, in conjunction with the radiological risks associated with operation and the uncertain benefits to disposal and long term safety.

  1. Intermediate Ethanol Blends Catalyst Durability Program

    Energy Technology Data Exchange (ETDEWEB)

    West, Brian H; Sluder, Scott; Knoll, Keith; Orban, John; Feng, Jingyu


    In the summer of 2007, the U.S. Department of Energy (DOE) initiated a test program to evaluate the potential impacts of intermediate ethanol blends (also known as mid-level blends) on legacy vehicles and other engines. The purpose of the test program was to develop information important to assessing the viability of using intermediate blends as a contributor to meeting national goals for the use of renewable fuels. Through a wide range of experimental activities, DOE is evaluating the effects of E15 and E20 - gasoline blended with 15% and 20% ethanol - on tailpipe and evaporative emissions, catalyst and engine durability, vehicle driveability, engine operability, and vehicle and engine materials. This report provides the results of the catalyst durability study, a substantial part of the overall test program. Results from additional projects will be reported separately. The principal purpose of the catalyst durability study was to investigate the effects of adding up to 20% ethanol to gasoline on the durability of catalysts and other aspects of the emissions control systems of vehicles. Section 1 provides further information about the purpose and context of the study. Section 2 describes the experimental approach for the test program, including vehicle selection, aging and emissions test cycle, fuel selection, and data handling and analysis. Section 3 summarizes the effects of the ethanol blends on emissions and fuel economy of the test vehicles. Section 4 summarizes notable unscheduled maintenance and testing issues experienced during the program. The appendixes provide additional detail about the statistical models used in the analysis, detailed statistical analyses, and detailed vehicle specifications.

  2. Connectomic intermediate phenotypes for psychiatric disorders

    Directory of Open Access Journals (Sweden)

    Alex eFornito


    Full Text Available Psychiatric disorders are phenotypically heterogeneous entities with a complex genetic basis. To mitigate this complexity, many investigators study so-called intermediate phenotypes that putatively provide a more direct index of the physiological effects of candidate genetic risk variants than overt psychiatric syndromes. Magnetic resonance imaging (MRI is a particularly popular technique for measuring such phenotypes because it allows interrogation of diverse aspects of brain structure and function in vivo. Much of this work however, has focused on relatively simple measures that quantify variations in the physiology or tissue integrity of specific brain regions in isolation, contradicting an emerging consensus that most major psychiatric disorders do not arise from isolated dysfunction in one or a few brain regions, but rather from disturbed interactions within and between distributed neural circuits; i.e., they are disorders of brain connectivity. The recent proliferation of new MRI techniques for comprehensively mapping the entire connectivity architecture of the brain, termed the human connectome, has provided a rich repertoire of tools for understanding how genetic variants implicated in mental disorder impact distinct neural circuits. In this article, we review research using these connectomic techniques to understand how genetic variation influences the connectivity and topology of human brain networks. We highlight recent evidence from twin and imaging genetics studies suggesting that the penetrance of candidate risk variants for mental illness, such as those in SLC6A4, MAOA, ZNF804A and APOE, may be higher for intermediate phenotypes characterised at the level of distributed neural systems than at the level of spatially localised brain regions. The findings indicate that imaging connectomics provides a powerful framework for understanding how genetic risk for psychiatric disease is expressed through altered structure and function of

  3. Early Events, Kinetic Intermediates and the Mechanism of Protein Folding in Cytochrome c

    Directory of Open Access Journals (Sweden)

    David S. Kliger


    Full Text Available Kinetic studies of the early events in cytochrome c folding are reviewed with a focus on the evidence for folding intermediates on the submillisecond timescale. Evidence from time-resolved absorption, circular dichroism, magnetic circular dichroism, fluorescence energy and electron transfer, small-angle X-ray scattering and amide hydrogen exchange studies on the t £ 1 ms timescale reveals a picture of cytochrome c folding that starts with the ~ 1-ms conformational diffusion dynamics of the unfolded chains. A fractional population of the unfolded chains collapses on the 1 – 100 ms timescale to a compact intermediate IC containing some native-like secondary structure. Although the existence and nature of IC as a discrete folding intermediate remains controversial, there is extensive high time-resolution kinetic evidence for the rapid formation of IC as a true intermediate, i.e., a metastable state separated from the unfolded state by a discrete free energy barrier. Final folding to the native state takes place on millisecond and longer timescales, depending on the presence of kinetic traps such as heme misligation and proline mis-isomerization. The high folding rates observed in equilibrium molten globule models suggest that IC may be a productive folding intermediate. Whether it is an obligatory step on the pathway to the high free energy barrier associated with millisecond timescale folding to the native state, however, remains to be determined.

  4. Choosing and using climate change scenarios for ecological-impact assessments and conservation decisions (United States)

    Amy K. Snover,; Nathan J. Mantua,; Littell, Jeremy; Michael A. Alexander,; Michelle M. McClure,; Janet Nye,


    Increased concern over climate change is demonstrated by the many efforts to assess climate effects and develop adaptation strategies. Scientists, resource managers, and decision makers are increasingly expected to use climate information, but they struggle with its uncertainty. With the current proliferation of climate simulations and downscaling methods, scientifically credible strategies for selecting a subset for analysis and decision making are needed. Drawing on a rich literature in climate science and impact assessment and on experience working with natural resource scientists and decision makers, we devised guidelines for choosing climate-change scenarios for ecological impact assessment that recognize irreducible uncertainty in climate projections and address common misconceptions about this uncertainty. This approach involves identifying primary local climate drivers by climate sensitivity of the biological system of interest; determining appropriate sources of information for future changes in those drivers; considering how well processes controlling local climate are spatially resolved; and selecting scenarios based on considering observed emission trends, relative importance of natural climate variability, and risk tolerance and time horizon of the associated decision. The most appropriate scenarios for a particular analysis will not necessarily be the most appropriate for another due to differences in local climate drivers, biophysical linkages to climate, decision characteristics, and how well a model simulates the climate parameters and processes of interest. Given these complexities, we recommend interaction among climate scientists, natural and physical scientists, and decision makers throughout the process of choosing and using climate-change scenarios for ecological impact assessment.

  5. Influencing Factors on Choosing Psychiatry as a Career: An Exploration in Chinese University Students. (United States)

    Zhong, Jiawei; Zheng, Luna; Chen, Xiaoling; Gao, Qianqian; Zhang, Bingren; Wang, Wei


    There is a consistent need of psychiatric professionals in the world including China, and a consistent challenge to recruit more medical students into the psychiatric careers. We aimed to look for factors which have an impact on career-choosing of psychiatry in Chinese university students. We invited 508 non-medical students (NM), 304 medical students without (MO) and 123 medical students with clinical internship experience (MW), to answer a matrix of 43 questions regarding factors influencing career-choosing of psychiatry. Answers to these questions were analyzed through exploratory and confirmatory factor analyses, once the latent factors were identified and structurally-validated, their mean scores in three groups of students were calculated. Five factors with five items each were identified, namely social status inferiority, career importance, practice reward, career preference, and practice stress. NM scored lower than MO and MW did on Social Status Inferiority; NM group scored higher than MO and MW groups did on Career Importance; MW scored lower than NM and MO did on Practice Reward and on Career Preference; Regarding Practice Stress, NM scored higher than MO did, who then in turn, scored higher than MW did. In addition, Practice Stress was positively correlated with advice of the medical educators; and Social Status Inferiority and Career Preference were positively correlated with the psychiatry teaching of the medical educators. Raising career rewards, improving social status, and reinforcing psychiatric education might help to recruit more medical students to specialize in psychiatry practicing.

  6. Choosing and remaining in mental health nursing: perceptions of Western Australian nurses. (United States)

    Harrison, Carole A; Hauck, Yvonne; Hoffman, Rosemary


    Mental health nursing has an ageing workforce with a critical shortage of nurses in Western Australia. Additionally, mental health is not the preferred career for many graduate nurses. Current challenges with recruitment and retention suggest that strategies are needed to address this issue. This research project adopted a novel approach that focused on exploring the positive aspects of why mental health nurses remain, rather than why they leave. A cross-sectional design was employed comprising a brief interview survey, and nurses working within one public mental health service in Western Australia were invited to participate. A total of 192 nurses participated across 5 months, from adult, older adult, forensic, and education/research programmes. Thematic analysis was conducted from five key questions, and responses from questions one and two are discussed in this paper: 'Why did you choose mental health nursing?' and 'Why do you remain in mental health nursing?'. The main themes extracted in response to choosing mental health nursing were wanting to make a difference, mental health captured my interest, encouraged by others, and opportunities. Subsequent themes extracted from responses to remaining in mental health nursing were facing reality, passion for mental health nursing, patient-centred caring, and workplace conditions. Findings will be utilized to inform strategies for recruitment and retention of graduate nurses; further development of support systems, such as preceptorship training and improving student clinical experiences; as well as improving professional development opportunities for existing mental health nurses.

  7. Modeling the Intention to Choose Natural Vaginal Delivery: Using Reasoned Action and Social Cognitive Theories

    Directory of Open Access Journals (Sweden)

    Safieh Kanani


    Full Text Available Background: The Behavioral Intention Model is one of the best and most widely models used regarding attitude of behavioral of pregnancy and decrease the rate of cesarean section (CS among pregnant women, except effect of atti-tude and subjective norms on behavioral intention. Two variables of self-efficacy, and outcome expectation, relate to individual’s behavior in an upcoming situation, and both of them are important at the development of behavior. The purpose of the present study was to develop a model to explain women’s inten-tion to choose natural vaginal delivery (NVD. The variables of self-efficacy and outcome expectations, derived from Bandura’s Social Cognitive Theory, and Behavioral Intention Model constructs were used to define the model.Methods: The study was descriptive and cross-sectional in nature and took place in Pars Abad, Iran in 2014. The non-probability sample consisted of 200 pregnant women who voluntarily participated in the study and provided the data. SPSS 21 and MPLUS 6.8 were employed to analyze the data.Results: Self-efficacy, outcome expectations, and attitude toward NVD were associated with intention to choose the NVD.Conclusion: The study findings may play a role in designing educational inter-ventions aimed at influencing the NVD and improving childbirth programs.

  8. A New System for Choosing the Form and Size of Complete Denture Anterior Teeth

    Directory of Open Access Journals (Sweden)

    Dario Melilli


    Full Text Available Introduction: In the absence of pre-extraction records, the choice of the size an form of anterior complete denture teeth can be extremely subjective. Several clinical and statistical parameters are usually used for choosing the correct size and form of the complete denture anterior teeth. Clinical Innovation: The technique consists of a system that allows the dentist to choose and, if necessary, easily change the dental mold during maxillomandibular recording session. The unique feature of the system is that six teeth of each mold are represented by veneers, which are connected to each other on the lingual surface by a fiber that allows each veneer some degree of movement. Discussion: This technique allows the three-dimensional verification of the patient’s esthetics and realistic phonetic test during the session of maxillomandibular records; if necessary, the dentist may easily replace the mold with a different one in form or size, without working the wax to move or replace a tooth.

  9. Donor Retention in Online Crowdfunding Communities: A Case Study of (United States)

    Althoff, Tim; Leskovec, Jure


    Online crowdfunding platforms like and Kick-starter allow specific projects to get funded by targeted contributions from a large number of people. Critical for the success of crowdfunding communities is recruitment and continued engagement of donors. With donor attrition rates above 70%, a significant challenge for online crowdfunding platforms as well as traditional offline non-profit organizations is the problem of donor retention. We present a large-scale study of millions of donors and donations on, a crowdfunding platform for education projects. Studying an online crowdfunding platform allows for an unprecedented detailed view of how people direct their donations. We explore various factors impacting donor retention which allows us to identify different groups of donors and quantify their propensity to return for subsequent donations. We find that donors are more likely to return if they had a positive interaction with the receiver of the donation. We also show that this includes appropriate and timely recognition of their support as well as detailed communication of their impact. Finally, we discuss how our findings could inform steps to improve donor retention in crowdfunding communities and non-profit organizations.

  10. Why do different people choose different university degrees? Motivation and the choice of degree

    Directory of Open Access Journals (Sweden)

    Anya eSkatova


    Full Text Available Different people choose which undergraduate degree to study at the university for different reasons. To date, there have been limited attempts to identify individual differences in motivation that drive the undergraduate degree choice. We identified that people choose university degrees for four reasons: career concerns (Career, intrinsic interest (Interest in the subject, an opportunity to help others (Helping and because they are looking for an easy option into higher education (Loafing. We investigated whether these motivation apply to the choice of undergraduate degree in two samples: (1 undergraduate (N = 989 and (2 prospective (N = 896 students. We developed the Motivations Influencing Course Choice (MICC questionnaire to measure these motivations. Scales of Helping, Career, Loafing and Interest showed good psychometric properties, showed validity with respect to general life goals and personality traits, and predicted actual and prospective degree choices. We demonstrated that medical degrees were chosen due to a mixture of Helping and Career, while engineering degrees were associated with Career and low interest in the degree. The choice of art and humanities degrees was driven by Interest and low concern about future career, accompanied with high Loafing. We also demonstrated gender differences: females were high in Helping (both samples and Interest (only in undergraduate sample motivation, while males scored higher in Career (only in undergraduate sample and Loafing (both samples. The findings can feed into both theoretical accounts of proximal motivation as well as help to improve degree programmes at universities and provide better career advice.

  11. Intermediate hosts of Angiostrongylus cantonensis in Tenerife, Spain. (United States)

    Martin-Alonso, Aarón; Abreu-Yanes, Estefanía; Feliu, Carlos; Mas-Coma, Santiago; Bargues, María Dolores; Valladares, Basilio; Foronda, Pilar


    The nematode Angiostrongylus cantonensis is the causative agent of human angiostrongyliasis, the main clinical manifestation of which is eosinophilic meningitis. Although this parasite has been found recently in its definitive rat host in Tenerife (Canary Islands, Spain), showing a widespread distribution over the north-east part of the island, there are no available data regarding which snail and/or slug species are acting as intermediate hosts on this island. Consequently, the objective of this work was to determine the possible role of three mollusc species, Plutonia lamarckii, Cornu aspersum and Theba pisana, as intermediate hosts of A. cantonensis in Tenerife. Between 2011 and 2014, 233 molluscs were collected from five biotopes where rats had been found previously to harbor either adult worms or antibodies against A. cantonensis, and the identification was carried out on the basis of morphological features and a LAMP technique. The prevalence of A. cantonensis larvae in the mollusc samples, based on morphological identification, was 19.3%, whereas 59 out of the 98 individuals (60.2%) analyzed by LAMP were positive. Positive results were obtained for the three mollusc species analyzed and two of the positive samples, both obtained from P. lamarckii, were confirmed as positive by 18S rRNA and ITS1 PCR. Sequence analysis of 18S rRNA PCR products showed 100% similarity with previously published A. cantonensis sequences. These results may be relevant from a public health point of view, since all the biotopes from which the samples were obtained were in inhabited areas or areas with human activity, but it is also important from the perspective of a possible transmission to other accidental hosts, such as dogs and horses, animals that are present in some of the areas analyzed.

  12. Atmospheric fates of Criegee intermediates in the ozonolysis of isoprene. (United States)

    Nguyen, Tran B; Tyndall, Geoffrey S; Crounse, John D; Teng, Alexander P; Bates, Kelvin H; Schwantes, Rebecca H; Coggon, Matthew M; Zhang, Li; Feiner, Philip; Milller, David O; Skog, Kate M; Rivera-Rios, Jean C; Dorris, Matthew; Olson, Kevin F; Koss, Abigail; Wild, Robert J; Brown, Steven S; Goldstein, Allen H; de Gouw, Joost A; Brune, William H; Keutsch, Frank N; Seinfeld, John H; Wennberg, Paul O


    We use a large laboratory, modeling, and field dataset to investigate the isoprene + O3 reaction, with the goal of better understanding the fates of the C1 and C4 Criegee intermediates in the atmosphere. Although ozonolysis can produce several distinct Criegee intermediates, the C1 stabilized Criegee (CH2OO, 61 ± 9%) is the only one observed to react bimolecularly. We suggest that the C4 Criegees have a low stabilization fraction and propose pathways for their decomposition. Both prompt and non-prompt reactions are important in the production of OH (28% ± 5%) and formaldehyde (81% ± 16%). The yields of unimolecular products (OH, formaldehyde, methacrolein (42 ± 6%) and methyl vinyl ketone (18 ± 6%)) are fairly insensitive to water, i.e., changes in yields in response to water vapor (≤4% absolute) are within the error of the analysis. We propose a comprehensive reaction mechanism that can be incorporated into atmospheric models, which reproduces laboratory data over a wide range of relative humidities. The mechanism proposes that CH2OO + H2O (k(H2O)∼ 1 × 10(-15) cm(3) molec(-1) s(-1)) yields 73% hydroxymethyl hydroperoxide (HMHP), 6% formaldehyde + H2O2, and 21% formic acid + H2O; and CH2OO + (H2O)2 (k(H2O)2∼ 1 × 10(-12) cm(3) molec(-1) s(-1)) yields 40% HMHP, 6% formaldehyde + H2O2, and 54% formic acid + H2O. Competitive rate determinations (kSO2/k(H2O)n=1,2∼ 2.2 (±0.3) × 10(4)) and field observations suggest that water vapor is a sink for greater than 98% of CH2OO in a Southeastern US forest, even during pollution episodes ([SO2] ∼ 10 ppb). The importance of the CH2OO + (H2O)n reaction is demonstrated by high HMHP mixing ratios observed over the forest canopy. We find that CH2OO does not substantially affect the lifetime of SO2 or HCOOH in the Southeast US, e.g., CH2OO + SO2 reaction is a minor contribution (production by stabilized Criegees is likely unimportant in regions dominated by the reactivity of ozone with isoprene. In contrast

  13. Phospho-Specific Antibody Probes of Intermediate Filament Proteins. (United States)

    Goto, Hidemasa; Tanaka, Hiroki; Kasahara, Kousuke; Inagaki, Masaki


    Intermediate filaments (IFs) form one of the major cytoskeletal systems in the cytoplasm or beneath the nuclear membrane. Accumulating data have suggested that IF protein phosphorylation dramatically changes IF structure/dynamics in cells. For the production of an antibody recognizing site-specific protein phosphorylation (a site- and phosphorylation state-specific antibody), we first employed a strategy to immunize animals with an in vitro-phosphorylated polypeptide or a phosphopeptide (corresponding to a phosphorylated residue and its surrounding sequence of amino acids), instead of a phosphorylated protein. Our established methodology not only improves the chance of obtaining a phospho-specific antibody but also has the advantage that one can predesign a targeted phosphorylation site. It is now applied to the production of an antibody recognizing other types of site-specific posttranslational modification, such as acetylation or methylation. The use of such an antibody in immunocytochemistry enables us to analyze spatiotemporal distribution of site-specific IF protein phosphorylation. The antibody is of great use to identify a protein kinase responsible for in vivo IF protein phosphorylation and to monitor intracellular kinase activities through IF protein phosphorylation. Here, we present an overview of our methodology and describe stepwise approaches for the antibody characterization. We also provide some examples of analyses for IF protein phosphorylation involved in mitosis and signal transduction.

  14. DegP Chaperone Suppresses Toxic Inner Membrane Translocation Intermediates (United States)

    Braselmann, Esther; Chaney, Julie L.; Champion, Matthew M.


    The periplasm of Gram-negative bacteria includes a variety of molecular chaperones that shepherd the folding and targeting of secreted proteins. A central player of this quality control network is DegP, a protease also suggested to have a chaperone function. We serendipitously discovered that production of the Bordetella pertussis autotransporter virulence protein pertactin is lethal in Escherichia coli ΔdegP strains. We investigated specific contributions of DegP to secretion of pertactin as a model system to test the functions of DegP in vivo. The DegP chaperone activity was sufficient to restore growth during pertactin production. This chaperone dependency could be relieved by changing the pertactin signal sequence: an E. coli signal sequence leading to co-translational inner membrane (IM) translocation was sufficient to suppress lethality in the absence of DegP, whereas an E. coli post-translational signal sequence was sufficient to recapitulate the lethal phenotype. These results identify a novel connection between the DegP chaperone and the mechanism used to translocate a protein across the IM. Lethality coincided with loss of periplasmic proteins, soluble σE, and proteins regulated by this essential stress response. These results suggest post-translational IM translocation can lead to the formation of toxic periplasmic folding intermediates, which DegP can suppress. PMID:27626276

  15. DegP Chaperone Suppresses Toxic Inner Membrane Translocation Intermediates. (United States)

    Braselmann, Esther; Chaney, Julie L; Champion, Matthew M; Clark, Patricia L


    The periplasm of Gram-negative bacteria includes a variety of molecular chaperones that shepherd the folding and targeting of secreted proteins. A central player of this quality control network is DegP, a protease also suggested to have a chaperone function. We serendipitously discovered that production of the Bordetella pertussis autotransporter virulence protein pertactin is lethal in Escherichia coli ΔdegP strains. We investigated specific contributions of DegP to secretion of pertactin as a model system to test the functions of DegP in vivo. The DegP chaperone activity was sufficient to restore growth during pertactin production. This chaperone dependency could be relieved by changing the pertactin signal sequence: an E. coli signal sequence leading to co-translational inner membrane (IM) translocation was sufficient to suppress lethality in the absence of DegP, whereas an E. coli post-translational signal sequence was sufficient to recapitulate the lethal phenotype. These results identify a novel connection between the DegP chaperone and the mechanism used to translocate a protein across the IM. Lethality coincided with loss of periplasmic proteins, soluble σE, and proteins regulated by this essential stress response. These results suggest post-translational IM translocation can lead to the formation of toxic periplasmic folding intermediates, which DegP can suppress.

  16. Comparative TEA for Indirect Liquefaction Pathways to Distillate-Range Fuels via Oxygenated Intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Eric; Snowden-Swan, Lesley J.; Talmadge, Michael; Dutta, Abhijit; Jones, Susanne; Ramasamy, Karthikeyan; Gray, Michael; Dagle, Robert; Padmaperuma, Asanga; Gerber, Mark; Sahir, Asad; Tao, Ling; Zhang, Yanan


    This paper presents a comparative techno-economic analysis of five conversion pathways from biomass to gasoline-, jet-, and diesel-range hydrocarbons via indirect liquefaction with specific focus on pathways utilizing oxygenated intermediates (derived either via thermochemical or biochemical conversion steps). The four emerging pathways of interest are compared with one conventional pathway (Fischer-Tropsch) for the production of the hydrocarbon blendstocks. The processing steps of the four emerging pathways include: biomass-to-syngas via indirect gasification, gas cleanup, conversion of syngas to alcohols/oxygenates, followed by conversion of alcohols/oxygenates to hydrocarbon blendstocks via dehydration, oligomerization, and hydrogenation. We show that the emerging pathways via oxygenated intermediates have the potential to be cost competitive with the conventional Fischer-Tropsch process. The evaluated pathways and the benchmark process generally exhibit similar fuel yields and carbon conversion efficiencies. The resulting minimum fuel selling prices are comparable to the benchmark at approximately $3.60 per gallon-gasoline equivalent, with potential for two new pathways to be more economically competitive. Additionally, the coproduct values can play an important role in the economics of the processes with oxygenated intermediates derived via syngas fermentation. Major cost drivers for the integrated processes are tied to achievable fuel yields and conversion efficiency of the intermediate steps, i.e., the production of oxygenates/alcohols from syngas and the conversion of oxygenates/alcohols to hydrocarbon fuels.

  17. Kinetics of formation of acrylamide and Schiff base intermediates from asparagine and glucose

    DEFF Research Database (Denmark)

    Hedegaard, Rikke Susanne Vingborg; Frandsen, Henrik; Skibsted, Leif H.


    From the concentration of glucose and asparagine as reactants and of acrylamide as product each determined by LC-MS during reaction in an acetonitrile/water (68:32) model system at pH 7.6 (0.04 M phosphate buffer) and from the relative concentration of the Schiff base intermediate......, the decarboxylated Schiff base intermediate, the Amadori product and aminopropionamide determined in the same reaction mixtures at 120 degrees C, 140 degrees C, 160 degrees C and 180 degrees C for up to 16 min, the energy of activation for formation of the Schiff base intermediate was found to have the value 50...... +/- 2 kJ mol(-1), while the apparent activation energy for formation of acrylamide was 64.4 +/- 0.6 kJ mol(-1), for formation of the decarboxylated Schiff base intermediate 92 +/- 2 kJ mol(-1), and for formation of the Amadori compound 59 +/- 4 kJ mol(-1), respectively. At high temperature conditions...

  18. A Case of Business Model Conversion Using Planning and Scheduling Application Having Intermediate Cutting Stock (United States)

    Takada, Masayoshi

    This paper describes the experience of developing a production planning and scheduling system, which makes more than 1700 kinds of end products from more than 300 kinds of large plates stocked in the intermediate warehouse. This system was mostly achieved with Constraint Logic Programming. As our business environments having changed, we ware in urgent need of converting our production method to the pull-type from the push-type. With the push-type production method, we have to keep our finish products in stock for three to four months and refill the stock in 30 days. The features of our system: it solved the complex network problem of 38 patterns found in the whole production process from cutting to shipment in generic way. At the former process, it also solved an optimization of the setups problem in the two-phase batch-type production.

  19. Structure and Mechanistic Implications of a Tryptophan Synthase Quinonoid Intermediate

    Energy Technology Data Exchange (ETDEWEB)

    Barends,T.; Domratcheva, T.; Kulik, V.; Blumenstein, L.; Niks, D.; Dunn, M.; Schlichting, I.


    Quinonoid intermediates play a key role in the catalytic mechanism of pyridoxal 5'-phosphate (PLP)-dependent enzymes. Whereas structures of other PLP-bound reaction intermediates have been determined, a high-quality structure of a quinonoid species has not been reported. We present the crystal structure of the indoline quinonoid intermediate of tryptophan synthase (see figure) and discuss its implications for the enzymatic mechanism and allosteric regulation.

  20. Structure Characterization of the Folding Intermediates of Proteins

    Institute of Scientific and Technical Information of China (English)


    Although the native state and the fully unfolded state of proteins have been extensively studied, the folding pathway and intermediates in the protein folding process have not been thoroughly investigated.To understand the mechanisms of protein folding, the early intermediates in the protein folding process must be clearly characterized.The present paper is a mini review containing 20 references involving studies on folding intermediates of several proteins.

  1. Efficient short step synthesis of Corey's tamiflu intermediate. (United States)

    Kipassa, Nsiama Tienabe; Okamura, Hiroaki; Kina, Kengo; Hamada, Toshiyuki; Iwagawa, Tetsuo


    Corey's tamiflu intermediate was synthesized from a bicyclolactam adduct obtained by base-catalyzed Diels-Alder reaction of N-nosyl-3-hydroxy-2-pyridone with ethyl acrylate. A compound that has the same array of functional groups with the Corey's intermediate was obtained in four steps from the DA adduct in 47% overall yield. The intermediate itself was also prepared efficiently by simply changing the protective group.

  2. Mechanical Properties of Intermediate Filament Proteins. (United States)

    Charrier, Elisabeth E; Janmey, Paul A


    Purified intermediate filament (IF) proteins can be reassembled in vitro to produce polymers closely resembling those found in cells, and these filaments form viscoelastic gels. The cross-links holding IFs together in the network include specific bonds between polypeptides extending from the filament surface and ionic interactions mediated by divalent cations. IF networks exhibit striking nonlinear elasticity with stiffness, as quantified by shear modulus, increasing an order of magnitude as the networks are deformed to large strains resembling those that soft tissues undergo in vivo. Individual IFs can be stretched to more than two or three times their resting length without breaking. At least 10 different rheometric methods have been used to quantify the viscoelasticity of IF networks over a wide range of timescales and strain magnitudes. The mechanical roles of different classes of cytoplasmic IFs on mesenchymal and epithelial cells in culture have also been studied by an even wider range of microrheological methods. These studies have documented the effects on cell mechanics when IFs are genetically or pharmacologically disrupted or when normal or mutant IF proteins are exogenously expressed in cells. Consistent with in vitro rheology, the mechanical role of IFs is more apparent as cells are subjected to larger and more frequent deformations.

  3. Is T Leonis a superoutbursting intermediate polar?

    CERN Document Server

    Vrielmann, S; Schmitt, J H M M


    We present an XMM-Newton analysis of the cataclysmic variable T Leo. The X-ray light curve shows sinusoidal variation on a period P_x equal to 0.89^{+0.14}_{-0.10} times the previously spectroscopically determined orbital period. Furthermore, we find a signal in the power spectrum at 414 sec that could be attributed to the spin period of the white dwarf. If true, T Leo would be the first confirmed superoutbursting intermediate polar IP). The spin profile is double-peaked with a peak separation of about 1/3 spin phases. This appears to be a typical feature for IPs with a small magnetic field and fast white dwarf rotation. An alternative explanation is that the 414 sec signal is a Quasi-periodic Oscillation (QPO) that is caused by mass transfer variation from the secondary, a bright region (``blob'') rotating in the disc at a radius of approximately ~9 Rwd or - more likely - a travelling wave close to the inner disc edge of a dwarf nova with a low field white dwarf. The XMM-Newton RGS spectra reveal double peak...

  4. Intergalactic stellar populations in intermediate redshift clusters

    CERN Document Server

    Melnick, J; Toledo, I; Selman, F J; Quintana, H


    A substantial fraction of the total stellar mass in rich clusters of galaxies resides in a diffuse intergalactic component usually referred to as the Intra-Cluster Light (ICL). Theoretical models indicate that these intergalactic stars originate mostly from the tidal interaction of the cluster galaxies during the assembly history of the cluster, and that a significant fraction of these stars could have formed in-situ from the late infall of cold metal-poor gas clouds onto the cluster. The models make predictions about the age distribution of the ICL stars, which may provide additional observational constraints. However, these models also over-predict the fraction of stellar mass in the ICL by a substantial margin. Here we present population synthesis models for the ICL of a dumb-bell dominated intermediate redshift (z=0.29) X-ray cluster for which we have deep MOS data obtained with the FORS2 instrument. In a previous paper we have proposed that the dumbell galaxy act as a grinding machine tearing to pieces t...

  5. The RGB Sample of Intermediate BL Lacs

    CERN Document Server

    Laurent-Mühleisen, S A; Feigelson, E D; Brinkmann, W; Siebert, J


    Combining newly identified and previously known BL Lacs from the RASS-Green Bank (RGB) catalog, we present a sample of 127 BL Lacs, the largest ever derived from a single uniform survey. A Complete sample of 33 objects brighter than O=18.0 mag is also presented. These samples are compared to other known BL Lac samples and are generally found to exhibit properties intermediate between those of the previously disparate classes of High and Low energy peaked BL Lacs (HBLs and LBLs, respectively). This result is most dramatic in the distribution of the X-ray to radio logarithmic flux ratios, where the RGB BL Lacs are shown to peak precisely where the sharp dichotomy between the two subclasses was previously seen. The alpha_ro vs alpha_ox diagram also shows the RGB sample smoothly bridges the gap between the previously distinct subclasses of LBLs and HBLs. We also find a weak, but statistically significant correlation between the composite X-ray spectral index alpha_xox and alpha_ro. This implies that the more LBL-...

  6. Pectin Methyl Esterase Activity Change in Intermediate Moisture Sun-Dried Figs after Storage

    Directory of Open Access Journals (Sweden)

    Dilek Demirbüker Kavak


    Full Text Available Intermediate moisture fruits can be obtained by rehydrating dried fruits. Intermediate moisture fruits are suitable for direct consumption compared to dry fruits and can be directly used in the production of various products such as bakery products, dairy products and candies. Aim of this study is to compare the pectin methyl esterase (PME activity of intermediate moisture figs which causes softening of the texture and to compare their microbial stability after 3 months storage period. For this purpose, dried figs were rehydrated in 30 and 80° C water until they reach 30% moisture content. Rehydrated samples were stored for 3 months at +4°C. Results showed that there was no statistically significant difference between the control samples and the samples rehydrated at 80°C according to the total viable counts. At the end of the storage period, results of residual PME activity in control samples was 24.1 μmol COOH min-1g-1, while it was found 17.4 μmol COOH min-1g-1 in samples rehydrated at 80°C. As a result rehydration conducted at 80°C provided 28% reduction in PME activity compared to the control samples rehydrated at 30°C, although it did not affect the microbial load significantly after storage.

  7. Research on Plastics Choosing Rule for Industrial Design%工业设计中塑料选择原则探讨

    Institute of Scientific and Technical Information of China (English)

    姜炎; 陈炳发


    工业设计是一门交叉学科,涉及到艺术、技术、工程等方面的知识,但目前较偏重于概念的呈现.工业设计的选材是连接设计概念与实际生产的桥梁,而塑料又是当前消费品的主要使用材料.通过对工业设计中塑料如何进行选择进行探讨,以提高设计造型与实际生产流通的结合度.%Industrial design is an interdisciplinary subject,which involves the art,technology,engineering and other knowledge. Material choosing is the bridge to connect design concepts and practice,and the plastic plays a great role in materials. This article discusses how to choose plastics in industrial design,so that the design is combined with the production.

  8. Implementation of the Intermediate Examination of Measuring Instrument%浅析测量仪器的期间核查与实施

    Institute of Scientific and Technical Information of China (English)



    从建立程序文件、确定核查对象、选择核查标准、确立核查间隔、制定核查方法等方面阐述测量仪器期间核查实施的过程。%This paper introduced the implementation of the intermediate examination of measuring instrument from five aspects as establishing procedure files, suring examination objects, choosing examination standard, establishing examination intervals and formulating examination methods.

  9. The freedom to choose neutron star magnetic field equilibria: Table 1. (United States)

    Glampedakis, Kostas; Lasky, Paul D.


    Our ability to interpret and glean useful information from the large body of observations of strongly magnetized neutron stars rests largely on our theoretical understanding of magnetic field equilibria. We answer the following question: is one free to arbitrarily prescribe magnetic equilibria such that fluid degrees of freedom can balance the equilibrium equations? We examine this question for various models for neutron star matter; from the simplest single-fluid barotrope to more realistic non-barotropic multifluid models with superfluid/superconducting components, muons and entropy. We do this for both axi- and non-axisymmetric equilibria, and in Newtonian gravity and general relativity. We show that, in axisymmetry, the most realistic model allows complete freedom in choosing a magnetic field equilibrium whereas non-axisymmetric equilibria are never completely arbitrary.

  10. Opting in and Creating Demand: Why Young People Choose to Teach Mathematics to Each Other (United States)

    Tucker-Raymond, Eli; Lewis, Naama; Moses, Maisha; Milner, Chad


    Access to science, technology, engineering, and mathematics fields serves as a key entry point to economic mobility and civic enfranchisement. Such access must take seriously the intellectual power of the knowledge and practices of non-dominant youth. In our case, this has meant to shift epistemic authority in mathematics from academic institutions to young people themselves. This article is about why high school-aged students, from underrepresented groups, choose to participate in an out-of-school time program in which they teach younger children in the domains of mathematics and computer science. It argues for programmatic principles based on access, identity engagement, relationship building, and connections to community to support underrepresented youth as learners, teachers, leaders, and organizers in mathematics-related activities using game design as the focus of activity.

  11. Live as we choose: The role of autonomy support in facilitating intrinsic motivation. (United States)

    Meng, Liang; Ma, Qingguo


    According to Self-determination Theory (SDT), autonomy is a basic psychological need, satisfaction of which may lead to enhanced intrinsic motivation and related beneficial outcomes. By manipulating the opportunity to choose between tasks of equal difficulty, throughout the motivational process, the effect of autonomy support was examined both behaviorally and electrophysiologically. More negative stimulus-preceding negativity (SPN) and an enlarged FRN loss-win difference wave (d-FRN) indicated an enhanced expectation toward the positive outcome (during the anticipation stage) as well as intensified intrinsic motivation toward the task (during the outcome appraisal stage) when choice was available. Taken together, results of the present study suggest d-FRN upon feedback as a real-time electrophysiological indicator of intrinsic/autonomous motivation and illustrate the important role of autonomy-supportive job design in the workplace.

  12. A new method for choosing parameters in delay reconstruction-based forecast strategies

    CERN Document Server

    Garland, Joshua; Bradley, Elizabeth


    Delay-coordinate reconstruction is a proven modeling strategy for building effective forecasts of nonlinear time series. The first step in this process is the estimation of good values for two parameters, the time delay and the reconstruction dimension. Many heuristics and strategies have been proposed in the literature for estimating these values. Few, if any, of these methods were developed with forecasting in mind, however, and their results are not optimal for that purpose. Even so, these heuristics -- intended for other applications -- are routinely used when building delay coordinate reconstruction-based forecast models. In this paper, we propose a general framework for choosing optimal parameter values for forecast methods that are based on delay-coordinate reconstructions. The basic calculation involves maximizing the shared information between each delay vector and the future state of the system. We illustrate the effectiveness of this method on several synthetic and experimental systems, showing tha...

  13. You Are What You See and Choose: Agreeableness and Situation Selection. (United States)

    Bresin, Konrad; Robinson, Michael D


    Agreeableness positively predicts subjective well-being, but why does it do so? Recent theorizing has highlighted possible substrates related to emotion regulation. Following suit, the present studies focus on the situation selection stage of the emotion regulation sequence. Undergraduate participants reported on their agreeableness levels and completed a picture-viewing task (Studies 1 and 2) or a media choice task (Study 3). Studies 1 and 2 found that the tendency to view negative pictures for a longer period of time than positive pictures was evident at low levels of agreeableness and absent at high levels. The Study 3 paradigm asked individuals whether they typically choose to expose themselves to positive or negative stimuli across diverse media sources. Preferences for positive media were more pronounced at higher levels of agreeableness. The results have systematic implications for understanding the emotional lives of disagreeable versus agreeable people.

  14. Analysis and design of a web-based decision support system for choosing higher education studies

    Directory of Open Access Journals (Sweden)

    Kostoglou Vassilis


    Full Text Available The vocational orientation of the youngsters who are about to enter, study, or have recently graduated at higher education (HE institutions, and linking HE with labor market are two research areas which have not been investigated extensively in Balkan countries. Job (or occupational profiles, among other tools used in vocational orientation, provide standardized and digitized descriptions of different professions. This article focuses on the analysis and the design of a web-based decision support system (DSS to assist its users in getting thoroughly informed about HE studies in Greece, and eventually in choosing their vocational prospects. Apart from reviewing the related previous research work and relevant web-based systems, we present the main elements of the system’s analysis and its design, the extensions that could lead to even more powerful systems, and conclusions about the advantages, limitations and practical application of the DSS.

  15. Description of women's personality traits and psychological vulnerability prior to choosing hormone replacement therapy

    DEFF Research Database (Denmark)

    Loekkegaard, E; Eplov, L F; Køster, A


    INTRODUCTION: Data suggest that women using hormone replacement therapy (HRT) represent a special subgroup of the general population regarding, for instance, cardiovascular risk factors and education. OBJECTIVE: To analyse if women who choose HRT are characterised a priori by high neuroticism score...... included Eysencks personality questionnaire concerning intro/extroversion and neuroticism. At the age of 45, the re-examination of the women included a test for psychological vulnerability. The participants reported whether or not they used HRT at the age of 40, 45, 51 and 60 years. The analyses comprised...... "never users" of HRT and "future users", defined as women who started HRT subsequent to baseline registration during the observation period. The groups were compared by multivariate statistical methods to adjust for confounding factors. RESULTS: Women with high neuroticism score at the age of 40 were...

  16. Instructors’ reasons for choosing problem features in a calculus-based introductory physics course

    Directory of Open Access Journals (Sweden)

    Edit Yerushalmi


    Full Text Available This study investigates how the beliefs and values of physics faculty influence their choice of physics problems for their students in an introductory physics course. The study identifies the goals these instructors have for their students, the problem features they believe facilitate those goals, and how those features correspond to problems they choose to use in their classes. This analysis comes from an artifact-based interview of 30 physics faculty teaching introductory calculus-based physics at a wide variety of institutions. The study concludes that instructors’ goals and the problem features they believe support those goals align with research-based curricular materials intended to develop competent problem solvers. However, many of these instructors do not use the beneficial problem features because they believe these features conflict with a more powerful set of values concerned with clarity of presentation and minimizing student stress, especially on exams.

  17. Children choose their own stories: the impact of choice on children's learning of new narrative skills. (United States)

    Khan, Kiren; Nelson, Keith; Whyte, Elisabeth


    Despite evidence that early narrative abilities are predictive of literacy skills and academic achievement, only limited progress has been made in understanding how the development of these narrative skills can be facilitated. The current study measured the effectiveness of a new narrative intervention conducted with 26 preschoolers. Children were assigned to one of two intervention conditions: an active-choice condition (able to choose story components) or a no-choice condition (story components were preselected). Both groups otherwise received the same explicit and engaging teaching of story grammar. As predicted, greater narrative skill gains were evident for the active-choice intervention; including larger gains on both central story grammar components and story information overall. Future implications for how stories might be presented to young children in order to more richly facilitate narrative skill acquisition are discussed.

  18. Entropy-Based Method of Choosing the Decomposition Level in Wavelet Threshold De-noising

    Directory of Open Access Journals (Sweden)

    Yan-Fang Sang


    Full Text Available In this paper, the energy distributions of various noises following normal, log-normal and Pearson-III distributions are first described quantitatively using the wavelet energy entropy (WEE, and the results are compared and discussed. Then, on the basis of these analytic results, a method for use in choosing the decomposition level (DL in wavelet threshold de-noising (WTD is put forward. Finally, the performance of the proposed method is verified by analysis of both synthetic and observed series. Analytic results indicate that the proposed method is easy to operate and suitable for various signals. Moreover, contrary to traditional white noise testing which depends on “autocorrelations”, the proposed method uses energy distributions to distinguish real signals and noise in noisy series, therefore the chosen DL is reliable, and the WTD results of time series can be improved.


    Directory of Open Access Journals (Sweden)

    Fernando Gustavo Dos Santos Gripe


    Full Text Available The present work is aimed at presenting a theoretical analysis of the main features of Open Source ERP systems, herein identified as success technical factors, in order to contribute to the establishment of parameters to be used in decision-making processes when choosing a system which fulfills the organization´s needs. Initially, the life cycle of ERP systems is contextualized, highlighting the features of Open Source ERP systems. As a result, it was verified that, when carefully analyzed, these systems need further attention regarding issues of project continuity and maturity, structure, transparency, updating frequency, and support, all of which are inherent to the reality of this type of software. Nevertheless, advantages were observed in what concerns flexibility, costs, and non-discontinuity as benefits. The main goal is to broaden the discussion about the adoption of Open Source ERP systems.

  20. Opting in and Creating Demand: Why Young People Choose to Teach Mathematics to Each Other (United States)

    Tucker-Raymond, Eli; Lewis, Naama; Moses, Maisha; Milner, Chad


    Access to science, technology, engineering, and mathematics fields serves as a key entry point to economic mobility and civic enfranchisement. Such access must take seriously the intellectual power of the knowledge and practices of non-dominant youth. In our case, this has meant to shift epistemic authority in mathematics from academic institutions to young people themselves. This article is about why high school-aged students, from underrepresented groups, choose to participate in an out-of-school time program in which they teach younger children in the domains of mathematics and computer science. It argues for programmatic principles based on access, identity engagement, relationship building, and connections to community to support underrepresented youth as learners, teachers, leaders, and organizers in mathematics-related activities using game design as the focus of activity.

  1. Analytic Hierarchy Process While Choosing Authentication with Radio Frequency Identification (RFID Systems

    Directory of Open Access Journals (Sweden)

    Mehmed Cihad Çağlayan


    Full Text Available Nowadays, it cannot be thought that companies carry out their activities stand away from technology. Especially, with Fourth Industrial Revolution 4.0 (Industry 4.0 smart technologies has started to play big role in factories. One of the innovation of industry 4.0 is RFI technology, today used by various industries in multiple areas, and there are widespread researches about this subject thus aims that to improve these technologies one step further. Besides that, management of technology becomes more crucial from many points of view of companies. Inaccurate technology investment usually might cause loss for companies. In this context, in order to choose best RFID option with defined criteria, at a company in automotive sector where technological development is followed and implemented, hierarchical model is established and from based on this model analytical hierarchy process used and an application is carried out.

  2. Guidelines for choosing molecular "alligator clip" binding motifs in electron transport devices (United States)

    Reuter, Matthew G.; Seideman, Tamar; Ratner, Mark A.


    We employ a one-electron, tight-binding model of an electrode-molecule-electrode junction to explore the fundamental relationship between adsorption geometry and electron transport, producing exact results (within this model). By varying the chemisorption location (e.g., atop a surface atom or in a hollow site between surface atoms) and the molecule-electrode coupling, we find that the largest currents are realized when the molecule (i) is highly coordinated by the surface and (ii) has favorable overlap with electrode states near the Fermi level. We also show the importance of electrode-induced molecular level shifting for certain adsorption geometries, which can cause molecular levels far from the Fermi level to conduct better than those near the Fermi level. Since all of these factors are greatly influenced by the chemical moiety used to link the molecule to an electrode, these results present a set of guidelines to help choose "alligator clips" for molecular electronic devices.


    Directory of Open Access Journals (Sweden)

    Maryam REHMAN


    Full Text Available This study explores relationships among Corporate Image, Intangible Perceived Quality, Choosing, Habit and Customer Loyalty and investigates the pivotal role these variables play in establishing and maintaining healthy base of loyal customers. Data were collected from Pakistani bank account holders and the empirical findings showed that corporate image plays the most important role in establishing and maintaining customer loyalty in the markets. Organizations always look forward to long lasting success. In order to be successful in the long run, they need to keep abreast with all of their stakeholders. Out of the stakeholders, customers are considered to be the most important one. Customer Loyalty is a psychological motive which today’s managers are considerate about. This study concludes that long-term success and sustainable reputation of an organization depends on customer loyalty.

  4. Realism and instrumentalism about the wave function. How should we choose?

    CERN Document Server

    Dorato, Mauro


    The main claim of the paper is that one can be 'realist' (in some sense) about quantum mechanics without requiring any form of realism about the wave function. We begin by discussing various forms of realism about the wave function, namely Albert's configuration-space realism, Duerr Zanghi and Goldstein's nomological realism about the wave function, Esfeld's dispositional reading of the wave function and Pusey Barrett and Rudolph's realism about the quantum state. By discussing the articulation of these four positions, and their interrelation, we conclude that instrumentalism about the wave function is by itself not sufficient to choose one over the other interpretations of quantum mechanics, thereby confirming in a different way the indetermination of the metaphysical interpretations of quantum mechanics.

  5. Refined Method for Choosing a Security Solution for Mobile Application – Web Service Interactions

    Directory of Open Access Journals (Sweden)

    Silvia Trif


    Full Text Available This paper aims to present a refined algorithm for choosing the appropriate security implementation for mobile applications connecting to web services. Common security scenarios are presented. Each scenario has several characteristics associated. The correlations between these security scenarios characteristics are computed and selected only the characteristics that are less correlated. The proposed algorithm inventories the available scenarios, inventories the requirements and selects the security scenario that match. A case study applies the proposed method to a situation where a WP7 application and a WCF service are interacting. Security scenarios for WCF services and their characteristics are described. Application security requirements are established. A security solution is proposed based on the results of the proposed method.

  6. ["Choosing wisely" in infectious diseases : Overuse of antibiotics - too few vaccinations]. (United States)

    Jung, N; Koop, H; Riessen, R; Galle, J-C; Jany, B; Märker-Herrmann, E


    The "choosing wisely" recommendations of the German Society of Internal Medicine (DGIM) and its specialist societies address diagnostic and therapeutic procedures, which are of particular medical importance but applied too often or too rarely in clinical practice. The aim is to further improve treatment of patients. Important topics of overuse and insufficient treatment related to the diagnostics, therapy, prevention and exclusion of infectious diseases could be identified. These topics not only play an important role in the discipline of infectious diseases but are also relevant for other internal medical disciplines. These topics related to infectious diseases have also been integrated into the recommendations of the German Society of Gastroenterology, Digestive and Metabolic Diseases as well as the German Societies for Internal Intensive Care and Emergency Medicine, for Pneumology, for Nephrology and for Rheumatology. The pivotal issues of the recommendations are the inappropriate use of antibiotics and insufficient vaccination rates.

  7. Long-Lived Intermediates in a Cooperative Two-State Folding Transition. (United States)

    El-Baba, Tarick J; Kim, Doyong; Rogers, Dylan B; Khan, Faizan A; Hales, David A; Russell, David H; Clemmer, David E


    Biomolecular folding often occurs through a cooperative two-state reactant ↔ product transition; the term cooperative does not convey that intermediate structures are nonexistent but rather that these states are not observable by existing experimental techniques. Because of this, few intermediates have been studied and characterized. Recently, ion mobility spectrometry (IMS) measurements revealed that the oligomer polyproline-13 (Pro13, which in propanol (PrOH) favors the right-handed helical PPI structure having adjacent pyrrolidine rings in a cis configuration) folds through six sequential long-lived intermediates as it converts to the all-trans-configured PPII structure that is favored in aqueous solutions. Here, we examine the PPIPrOH → PPIIaq folding transition for a HisPro13 sequence, i.e., Pro13 having a single histidine residue added to the N-terminus. Remarkably, the IMS measurements show that, upon addition of histidine, all of the IMS peaks associated with intermediate structures disappear. Instead, HisPro13 folds via a cooperative two-state transition, delayed by a significant induction period. The induction period is temperature dependent-shifting the transition to longer times at lower temperatures. Equilibrium studies show that the HisPro13 PPIPrOH → PPIIaq transition is endothermic but favored entropically. From these clues, we propose a sequential folding mechanism and develop a model that suggests that ∼13-17 long-lived intermediates are likely responsible for the induction period. In this model, intermediates are separated by average individual activation barriers of ∼90 kJ·mol(-1), and are entropically favorable.

  8. Mechanism of benzaldehyde lyase studied via thiamin diphosphate-bound intermediates and kinetic isotope effects. (United States)

    Chakraborty, Sumit; Nemeria, Natalia; Yep, Alejandra; McLeish, Michael J; Kenyon, George L; Jordan, Frank


    Direct spectroscopic observation of thiamin diphosphate-bound intermediates was achieved on the enzyme benzaldehyde lyase, which carries out reversible and highly enantiospecific conversion of ( R)-benzoin to benzaldehyde. The key enamine intermediate could be observed at lambda max 393 nm in the benzoin breakdown direction and in the decarboxylase reaction starting with benzoylformate. With benzaldehyde as substrate, no intermediates could be detected, only formation of benzoin at 314 nm. To probe the rate-limiting step in the direction of ( R)-benzoin synthesis, the (1)H/ (2)H kinetic isotope effect was determined for benzaldehyde labeled at the aldehyde position and found to be small (1.14 +/- 0.03), indicating that ionization of the C2alphaH from C2alpha-hydroxybenzylthiamin diphosphate is not rate limiting. Use of the alternate substrates benzoylformic and phenylpyruvic acids (motivated by the observation that while a carboligase, benzaldehyde lyase could also catalyze the slow decarboxylation of 2-oxo acids) enabled the observation of the substrate-thiamin covalent intermediate via the 1',4'-iminopyrimidine tautomer, characteristic of all intermediates with a tetrahedral C2 substituent on ThDP. The reaction of benzaldehyde lyase with the chromophoric substrate analogue ( E)-2-oxo-4(pyridin-3-yl)-3-butenoic acid and its decarboxylated product ( E)-3-(pyridine-3-yl)acrylaldehyde enabled the detection of covalent adducts with both. Neither adduct underwent further reaction. An important finding of the studies is that all thiamin-related intermediates are in a chiral environment on benzaldehyde lyase as reflected by their circular dichroism signatures.

  9. Choosing to biopsy or refer suspicious melanocytic lesions in general practice

    Directory of Open Access Journals (Sweden)

    Robison Sean


    Full Text Available Abstract Background General practitioners (GPs are involved in the management of most melanocytic skin lesions in Australia. A high quality biopsy technique is a crucial first step in management, as it is recognized that poor techniques can mislead, delay, or miss a diagnosis of melanoma. There has been little published on the biopsy decisions and techniques of GPs. This study aims to describe the current management choices made by GPs for suspicious melanocytic skin lesions and to compare their choices with the best practice guidelines. Methods An anonymous survey of GPs presented with three clinical scenarios with increasing complexity of melanoma in which a referral or biopsy decision was specified. Results 391 mailed surveys with a 76.3% response rate. Mean biopsy experience was 4.14 biopsies per GP per month. The rates of choosing to refer among the three scenarios were 31%, 52% and 81% respectively, with referral to surgery being the most common choice (81%. Most biopsy techniques (55% were chosen according to best practice guidelines, although non-guideline biopsy techniques chosen included shave (n = 10, punch biopsy (n = 57, wide excisions (n = 65, and flaps (n = 10. The few GPs (n = 5 who identified themselves as skin specialist GPs were no more likely to adhere to guidelines than their colleagues. Conclusion A majority of referrals and biopsies were chosen by GPs according to best practice guidelines, but concern remains for the high proportion of GPs making non-guideline based choices. How GPs choose to biopsy or refer needs further training, audit, and research if Australia is to improve the outcome of melanoma management in general practice.

  10. Religious freedom and family life: reflections on the right to choose. (United States)

    Paltrow, L M


    Family integrity, family life and family privacy, and parental authority are the arguments used to convince legislators to pass parental consent and notification laws and judges to uphold them. Those who favor these laws argue that the government is interfering with family life and undermining parental authority when it permits minors to get abortions without parental consent or notification. It is time to challenge the family integrity argument. Too often the notion is accepted that abortion is unique in the sense that it is unlike all other constitutionally protected rights. Imagine a 16-year-old girl who lives in a rigidly orthodox Catholic family who is never encouraged to read and think, even about religious laws. One day she discovers that that she is pregnant. This young woman thinks of her dreams of the future and her ability to care for and raise a child. Ultimately, she decides to have an abortion. She finds a local doctor and clinic and has an abortion without her parents' knowledge or consent. Carol Gilligan, in her book, "In a Different Voice," examines the psychological development of women. Her studies reveal that, for women, decisions about pregnancy are among the most significant in providing opportunities for moral development, personal growth, and the separation from family that achieving adulthood requires. Yet, some would deny women that opportunity to make these decisions by requiring parental consent or notice. The right to choose abortion is not all that different from other constitutionally protected individual rights. Both free speech and the right to choose provide unequalled opportunities for people to become responsible, thinking citizens. Possibly abortion is not unique, since many decisions affect and involve other's lives. What is unique is that moral reasoning is not attributed to young women who must make choices about pregnancy.

  11. Choosing preclinical study models of diabetic retinopathy: key problems for consideration

    Directory of Open Access Journals (Sweden)

    Mi XS


    Full Text Available Xue-Song Mi,1,2 Ti-Fei Yuan,3,4 Yong Ding,1 Jing-Xiang Zhong,1 Kwok-Fai So4,5 1Department of Ophthalmology, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China; 3School of Psychology, Nanjing Normal University, Nanjing, People’s Republic of China; 4Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; 5Guangdong-Hongkong-Macau Institute of Central Nervous System, Jinan University, Guangzhou, People’s Republic of China Abstract: Diabetic retinopathy (DR is the most common complication of diabetes mellitus in the eye. Although the clinical treatment for DR has already developed to a relative high level, there are still many urgent problems that need to be investigated in clinical and basic science. Currently, many in vivo animal models and in vitro culture systems have been applied to solve these problems. Many approaches have also been used to establish different DR models. However, till now, there has not been a single study model that can clearly and exactly mimic the developmental process of the human DR. Choosing the suitable model is important, not only for achieving our research goals smoothly, but also, to better match with different experimental proposals in the study. In this review, key problems for consideration in choosing study models of DR are discussed. These problems relate to clinical relevance, different approaches for establishing models, and choice of different species of animals as well as of the specific in vitro culture systems. Attending to these considerations will deepen the understanding on current study models and optimize the experimental design for the final goal of preventing DR. Keywords: animal model, in vitro culture, ex vivo culture, neurovascular dysfunction

  12. Choosing and using climate-change scenarios for ecological-impact assessments and conservation decisions. (United States)

    Snover, Amy K; Mantua, Nathan J; Littell, Jeremy S; Alexander, Michael A; McClure, Michelle M; Nye, Janet


    Increased concern over climate change is demonstrated by the many efforts to assess climate effects and develop adaptation strategies. Scientists, resource managers, and decision makers are increasingly expected to use climate information, but they struggle with its uncertainty. With the current proliferation of climate simulations and downscaling methods, scientifically credible strategies for selecting a subset for analysis and decision making are needed. Drawing on a rich literature in climate science and impact assessment and on experience working with natural resource scientists and decision makers, we devised guidelines for choosing climate-change scenarios for ecological impact assessment that recognize irreducible uncertainty in climate projections and address common misconceptions about this uncertainty. This approach involves identifying primary local climate drivers by climate sensitivity of the biological system of interest; determining appropriate sources of information for future changes in those drivers; considering how well processes controlling local climate are spatially resolved; and selecting scenarios based on considering observed emission trends, relative importance of natural climate variability, and risk tolerance and time horizon of the associated decision. The most appropriate scenarios for a particular analysis will not necessarily be the most appropriate for another due to differences in local climate drivers, biophysical linkages to climate, decision characteristics, and how well a model simulates the climate parameters and processes of interest. Given these complexities, we recommend interaction among climate scientists, natural and physical scientists, and decision makers throughout the process of choosing and using climate-change scenarios for ecological impact assessment. Selección y Uso de Escenarios de Cambio Climático para Estudios de Impacto Ecológico y Decisiones de Conservación.

  13. Evaluation of the Canadian Rheumatology Association Choosing Wisely recommendation concerning anti-nuclear antibody (ANA) testing. (United States)

    Ferrari, Robert


    The objective of this study was to evaluate the Canadian Rheumatology Association Choosing Wisely recommendation concerning anti-nuclear antibody (ANA) testing. Patients with joint pain/stiffness/swelling were assessed to determine if ANA testing was indicated. An a priori threshold was set before ANA testing would be considered. Those who did not have ANA testing ordered were followed for 1 year to determine if any of them went on to have a diagnosis of systemic lupus erythematosus (SLE) or other connective tissue disease. A parallel study was conducted with a similar a priori threshold for the use of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody testing in the diagnosis of rheumatoid arthritis (RA), and again, patients were followed for 1 year. A total of 866 subjects were examined, 509 females (58.8 %) and 357 males (41.2 %). The mean age of the group was 47.5 ± 16.8 years. The mean duration of symptoms was 12.0 ± 5.6 weeks. Of the 866 subjects, 68 met an a priori threshold for ordering ANA, RF, and anti-CCP testing. Of these 68, there was a newly diagnosed case of SLE, 4 newly diagnosed cases of RA, and 3 cases of polymyalgia rheumatica. The remaining 798 subjects were followed for approximately 1 year and none developed evidence of SLE, RA, or other connective tissue disease. In the evaluation of non-specific musculoskeletal symptoms, setting an a priori threshold for ordering serology in keeping with the spirit of the Canadian Rheumatology Association Choosing Wisely recommendation for antibody testing results in a very low risk of missing a case of systemic lupus erythematosus or rheumatoid arthritis.

  14. Reasons for mini-implants failure: choosing installation site should be valued!

    Directory of Open Access Journals (Sweden)

    Alberto Consolaro


    Full Text Available Mini-implant loss is often associated with physical and mechanical aspects that result from choosing an inappropriate placement site. It is worth highlighting that: a Interdental alveolar bone crests are flexible and deformable. For this reason, they may not offer the ideal absolute anchorage. The more cervical the structures, the more delicate they are, thus offering less physical support for mini-implant placement; b Alveolar bone crests of triangular shape are more deformable, whereas those of rectangular shape are more flexible; c The bases of the alveolar processes of the maxilla and the mandible are not flexible, for this reason, they are more likely to receive mini-implants; d The more cervical a mini-implant is placed, the higher the risk of loss; the more apical a mini-implant is placed, the better its prognosis will be; e 3D evaluations play a major role in planning the use of mini-implants. Based on the aforementioned considerations, the hypotheses about mini-implant loss are as follows: 1 Deflection of maxillary and mandibular alveolar processes when mini-implants are more cervically placed; 2 Mini-implants placed too near the periodontal ligament, with normal intra-alveolar tooth movement; 3 Low bone density, low thickness and low alveolar bone volume; 4 Low alveolar cortical bone thickness; 5 Excessive pressure inducing trabecular bone microfracture; 6 Sites of higher anatomical weakness in the mandible and the maxilla; 7 Thicker gingival tissue not considered when choosing the mini-implant.

  15. Delineating Two Exclusive Views on Power of Choosing & Modal Dynamics of Double Performances

    Directory of Open Access Journals (Sweden)

    Mahshad Jalalpourroodsari


    Full Text Available This article endeavors to make use of the theories presented by French semiotician Algirdas Julien Greimas, in order to demonstrate the main structural exchanges inherent within some of the critical choices and acute performances at the heart of Ibsen’s A Doll’s House. In this study, the syntagmatic exchange structures and the paradigmatic structures of gift and test which are at work within the narrative line of the play are discussed and exteriorized so that there can be a better apprehension and appreciation for the internal path of signification concerning the relation of the main couple actants (Note 1 in this discourse. It will be seen how the power to choose of the protagonists of exchange or loci of exchange structures might be exercised or overlooked and how one may devalorise and negate an offer of exchange based on the way it is modally interpreted. This study will contemplate on the manner in which one’s voluntary renunciation of rights may metamorphose into a manipulative and deceptive dispossession of that right, when actants get involved in parallel programmes which are complementary and at the same time contradictory to one another. Thus, through adopting such a perspective towards the choices made and the dilemmas faced by the main actants of Ibsen’s discourse, one gets the chance to have a more tangible canvas on which to draw Nora and Torvald’s change of hearts and malfunctioning transactions.  Keywords: Exchange Structure, Double Performance, Power of Choosing, Dilemma, Free Choice, Veridictory  Modality, Overmodality, Valence, Attribution, Renunciation, Dispossession, Appropriation.

  16. Study on the Intermediate in the o-Phenylenediamine Oxidative Reaction Using Hemoglobin as A Mimetic Peroxidase in Aqueous-Organic Two Phase

    Institute of Scientific and Technical Information of China (English)


    Hemoglobin was used as a mimetic enzyme for peroxidase to catalyze the oxidative reaction ofo-phenylenediamine with H2O2 which functioned as an oxidant. The relationship between physicochemicalproperties of the intermediate and enzymatic activity of hemoglobin was studied. Since the solubility of theintermediate in the reaction is higher in butanol phase than in water phase, the intermediate itself diffusedfrom the aqueous phase to the butanol phase. The experimental results showed that the rate of product andthe stability of intermediate were associated with the temperature and the pH value of the buffer. The for-mation rate of intermediate and half-life period reveal the maximal in pH7, nevertheless, the whole rate ofthe catalytic reaction is the greatest in pH5, which the ratio of the initial rate in final product formationcompared to that intermediate formation is the greatest.

  17. Intermediate frequency magnetic field and chick embryotoxicity. (United States)

    Nishimura, Izumi; Tanaka, Keiko; Negishi, Tadashi


    Intermediate frequency magnetic fields (MFs) have widely been used in industrial machines and home appliances, such as induction heating cookers, although toxicity studies to evaluate the potential health risks of such fields are insufficient. In induction heating cookers, the MF source (i.e. hobs), is located near the abdominal position of a person cooking. Hence, developmental effects on the fetus may be a concern in case the person is a pregnant woman. Fertile White Leghorn eggs (60/group) were either exposed to 20 kHz, 1.1 mT(rms) or 60 kHz, 0.11 mT(rms) sinusoidal MFs for 19 days during embryogenesis. The same number of eggs served as a control group. In addition, a sham-sham experiment was conducted to validate the equality between exposure and control facilities. After exposure, embryos were examined for mortality rate and stage. Live embryos were evaluated for developmental stage and gross and skeletal anomalies. Length of upper beak and leg digits was also measured. Examinations were conducted in a blinded fashion to ensure quality assurance; experiments were triplicated for each frequency to confirm the outcome reproducibility. Mortality rate and stage, incidence of malformed embryos, and developmental variables in live embryos were found to be similar between the MF-exposed and corresponding control group. Incidence of gross anomalies such as mandibular edema and skeletal anomalies such as coccyx defects were low across the experiments, and no significant group differences were noted. In conclusion, exposure to 20 kHz or 60 kHz MF did not produce any significant teratogenic developmental effects in chick embryos.

  18. How to choose financial-planning product%银行理财产品也需"看人下菜碟"

    Institute of Scientific and Technical Information of China (English)



    @@ 近年来,金融机构推出的各类理财产品令人目不暇接,几乎每天都有理财新产品问世.在数量急剧增加的同时,理财产品同质化现象也非常明显.各类理财产品几乎都是证券、外汇、保险、基金等投资产品的组合,目标客户群大同小异.

  19. Media Choosing of Products Advertisement%浅谈产品广告的媒体选择

    Institute of Scientific and Technical Information of China (English)




  20. Die Motions of New Forging Process Using IntermediateDie Assembly

    Institute of Scientific and Technical Information of China (English)


    The die motions of a new forging process for automation with an intermediate die assembly called hamburger were analyzed through high-speed video pictures. The results showed that the upper die that is assembled in the hamburger and retained over the lower die collides few times with the ram and workpiece, but sound products can be obtained with less sticking in spite of the lowered impacts of hit.