Studies on the influence on the excretory kinetics of 125I-Adipiodon

International Nuclear Information System (INIS)

Koenig, H.

1982-01-01

The possibility of influencing distribution and elimination of 125 I-Adipiodon ( 125 I-iodipamide meglumine) by a preceding administration of Falignost (iomeglamic acid) as well as by dose-time variants of the mechanic intravenous application of contrast medium was tested in 55 anicteric and 2 icteric patients within clinically indicated cholegraphic examination with the aim of methodical optimization. For the detection of principal regularities comparative studies with 125 I-Adipiodon and Falignost in rats as well as examinations of protein binding of 125 I-Adipiodon in the plasm of rats and in the plasm and in mixed serum (application in vitro) of patients by gel filtration with Epidex B 2 coarse and batch operation on more than 1,200 samples were additionally carried out. For combined cholecystography with intravenous infusion of Adipiodon in immediate temporal connection with the administration of Falignost a reduced visibility of the biliary tract in the X-ray picture is not to be expected as the consequence of the mutual influence of the contrast media. For intact excretory function of liver and kidneys the combined cholecystography can be recommended. The effects of a dose increase, of protracted infusion of Adipiodon and of the intravenous administration of 0.01 g metroclopramide on the demonstration of the biliary tract in the intravenous cholegram are outlined. (author)

Ultrasonographic ejection fraction of normal gallbladder

Energy Technology Data Exchange (ETDEWEB)

Park, Jin Hun; Kim, Seung Yup; Park, Yaung Hee; Kang, Ik Won; Yoon, Jong Sup [Hangang Sacred Heart Hospital, Halym College, Chuncheon (Korea, Republic of)

1984-06-15

Real-time ultrasonography is a simple, accurate, noninvasive and potentially valuable means of studying gallbladder size and emptying. The authors calculated ultrasonographically the ejection fraction of 80 cases of normally functioning gallbladder on oral cholecystography, from June 1983 to April 1984, at the department of radiology, Hangang Sacred Heart Hospital. The results were obtained as follows; 1. Ultrasonographic Ejection Fraction at 30 minutes after the fatty meal was 73.1{+-}16.85. 2. There was no significant difference in age and sex, statistically.

Radiological observations of the thorax and abdomen of the piglet

International Nuclear Information System (INIS)

Wood, A.K.W.

1985-01-01

A contrast radiographic study of the urinary and gastrointestinal system was carried out in 43 animals, with the aid of barium sulfate, orally for esophageal, stomach, small intestine and large intestine studies; barium sulfate as an enema to complete the large intestine studies; sodium and meglumine diatrizoate intravenously for urography and iodipamide meglumine intravenously for cholecystography. Both unanesthetized and anesthetized or tranquilized animals were used in the study. The results of the study are illustrated, and contrasted with studies of a similar nature in other animals

Studies on the gonad dose in x-ray examination for the two day human dock at Nissei Hospital

International Nuclear Information System (INIS)

Murakami, Shozo; Muraoka, Tsutomu; Ishigaki, Naoya; Ono, Toshio; Nakai, Toshio

1979-01-01

The gonad dose in x-ray examination should be reduced to the minimum extent. The purpose of this study is to estimate the gonad dose in x-ray examination for the two day-human dock at Nissei Hospital. The gonad dose to 40 males and 60 females was measured on cholecystography and gastrointestinal radiography. Dose measurement was performed using a thermoluminescence dosimeter. The results were as follows: Mean gonad dose is 6.9 mR to male and 44.2 mR to female, so that gonad dose to female is 6.4 times greater than that to male. (author)

Bilio-pancreatic common channel (BPCC) in children

International Nuclear Information System (INIS)

Suarez, F.; Bernard, O.; Gauthier, F.; Valayer, J.; Brunelle, F.

1987-01-01

Twelve patients (11 girls and 1 boy) with dilated bile ducts and anomalous junction between the common bile duct and pancreatic duct are reported. All patients underwent preoperative opacification of the bile ducts either by transhepatic cholangiography or percutaneous cholecystography. Abdominal pain and jaundice were the main clinical symptoms. Reflux of pancreatic enzymes in the bile duct was proven by measuring amylase and lipase activity in the biliary system after IV injection of 1 IU/kg of cholecystokinin. All patients were operated upon. Bile duct size returned to normal in all patients who are clinical well with a follow-up from 6 to 1 years. (orig.)

Functional scintiscanning with sup(99m)technetium-diethyl-HIDA as a nuclear diagnostical means in hepatobiliary diseases

International Nuclear Information System (INIS)

Hummel, G.

1982-01-01

The study aimed to delimit the value of sequential hepatobiliary scintiscanning with the aid of sup(99m)technetium-diethyl-HIDA as a diagnostical method in functional or morphological disorders of the gall bladder and bile ducts. The most frequent indications to carry through the investigation therefore were inflammations calculosis in the biliary system, suspected intrahepatic icterus or conditions following biliodigestive anastomoses. Special attention was directed to the question in how far the results were in accordance with those of x-ray cholecystography/cholangiography. Furthermore the possibility for semiquantitative evaluation of serial functional scintiscanning was looked into and clearance determinations were carried through in part of the patients investigated. (orig./MG) [de

The gallbladder and biliary ducts

International Nuclear Information System (INIS)

Amberg, J.R.; Juhl, J.H.; Univ. of California, San Diego, Medical Center, Veterans Administration Hospital, La Jolla, CA)

1987-01-01

There is an extensive menu for investigating the hepatobiliary area. From the simplicity of the plain film to the expense of magnetic resonance imaging to the invasiveness of percutaneous transhepatic cholangiography, all modalities can contribute to the goal of a correct diagnosis. Not all are needed in each patient; thus a careful evaluation of the clinical needs is required before proceeding. It is also apparent that changes are occurring rapidly. The current importance of gallbladder ultrasonography and computerized tomography and the decline of oral cholecystography and intravenous cholangiography in biliary tract diagnosis was impossible to anticipate a decade ago. Because not all modalities are available in all communities, it is important to tailor the diagnostic algorithm to local skills and equipment

Pre-surgical radiologic diagnostics of pancreas diseases

International Nuclear Information System (INIS)

Seifried, C.

1979-01-01

At the example of a comparative study with 112 patients it should be demonstrated that the different radiologic techniques are complementary in pancreas diagnostics with respect to their indication and proposition. The study yields the following procedure for the pancreas diagnostics: cysts and pancreatites are diagnosed by means of sonography and computed tomography. Stomach-colon-barium passage and intravenous cholangio cholecystography can be applied for clarification of functional reactions on the stomach-colon regions, respectively the biliary region. Only in a complicated process, e.g. in a sustaining tumor suspicion or before surgery should angiography be used. In pancreatitis also the endoscopic retrograde cholangio-pancreatiography is used. Tumors are generally submitted to angiography for clarification of diagnosis, resiscivity, and vessel conditions. (orig./MG) [de

Scintigraphic study on the motility of stomach and gallbladder in non-ulceric dyspepsia patients

International Nuclear Information System (INIS)

Fu Min; Xu Guomin; Xu Denren

1992-01-01

Cholecystography with 99m Tc-EHIDA was performed to assess the preprandial empty function of gallbladder and then solid meal labelled with 99m Tc-DTPA was given to assess the postprandial empty function of stomach in 25 patients with NUD. The examinations were repeated in 15 patients with hypomotilitic stomach and gallbladder following administration of Domperidone 20 mg t.i.d for four weeks. The results showed that the empty function of stomach was closely related to the amplitude and frequency of antrum contractile peristaltic waves, all NUD patients who had delayed gastric empty also had hypomotilitic gallbladder. This may be one of the pathophysiologic bases of NUD. The movements of stomach and gallbladder both preprandial and postprandial were synchronous. Domperidone can restore hypomotility of stomach and gallbladder in NUD patients to normal, and the movements of stomach and gallbladder still remained synchronous

Testing the efficiency and the tolerance of ceruletid during X-ray examination of the small intestine

Energy Technology Data Exchange (ETDEWEB)

Sargent, E N; Halls, J M

1981-04-15

A comparative test with 80 patients who were either administered Ceruletid i.m. or given stimulating food to make the gall bladder contract for the oral cholecystography revealed that Ceruletid is suitable for contraction of the gall bladder and improves the presentation of the ductus cysticus and the choledochus. During the contraction of the gall bladder, no side effects were observed, even if small or big gallstones had been found. An additional test with 30 patients whose small intestines were examined radiologically showed that Ceruletid, administered intramusucularly, has the effect of considerably reducing the transit time of the barium meal into the ileocoecal region. The average transit time after injecting Ceruletid was 15 minutes which is 80 minutes after physiological salt solution as a placebo. The intramuscular injection of Ceruletid in a dose of 0.3 ..mu..g/kg body weight is a safe and effective method to increase the gall bladder contraction and to shorten the time necessary for transition through the small intestine.

Dynamic biliary cholecystography with mebrofenin-Tc-99m in a patient with benign recurrent intrahepatic cholestasis

International Nuclear Information System (INIS)

Tadzher, I.S.; Grujovska, S.; Todorovski, G.; Arsova, S.

1996-01-01

A Caucasian boy with a 16-year history of benign recurrent intrahepatic cholestasis (BRIC) presented dissociation between normal hepatic extraction fraction of mebrofenin-Tc-99m (HEF over 90%) and that of intensive delayed liver 'washout' T 1/2 210 m (normal 20-25 m). This is the second case in Macedonia (population 2.3 million) showing the same pattern of bile dynamic with mebrofenin-Tc-99m: normal HEF, prolonged 'washout'. In Rotor's disease and Dubin-Johnson's syndrome HEF is depressed and 'washout' delayed, whereas in Gilbert's syndrome we found both parameters normal. In our patient the episodes of pruritus were intensive and prolonged, hyperbilirubinaemia 50-100 micromol/L. Gallbladder was hypovolemic, ejection fraction reduced (59%, normal with the employed method over 70%). Growth, body weight and bone age were subnormal. Technetium-sulfur-colloid scans showed enlarged liver, splenomegaly and reduced portal contribution to hepatic blood flow (65%, normal over 70%). (Author)

Diagnostic value of ultrasonography, infusion tomography of the gall-bladder and sup(99m)Tc-DIDA hepatobiliary scanning in cases of suspected acute cholecystitis

Energy Technology Data Exchange (ETDEWEB)

Holst Pedersen, J.; Hancke, S.; Christensen, B.; Gammelgaard, J.; Haubek, A.; Ingemann Jensen, L.; Munck, O.; Wied, U. (Koebenhavns amts sygehus i Herlev, kirurgisk gastroenterologisk afd., Herlev, Denmark)

1982-01-01

Ultrasonography, infusion tomography of the gall-bladder and sup(99m)Tc-diethyl acetanilide iminodiacetic acid (DIDA) hepatobiliary scanning were compared in a prospective investigation of 45 consecutive patients in whom acute cholecystitis was suspected clinically. The definitive diagosis of acute cholecystitis was established or excluded at operation in 35 patients, by oral cholecystography in five and by intravenous cholangiography in five. The predictive values of positive and negative results of investigation were 100% and 83%. respectively, with ultrasonography and 98% and 88%, respectively, in hepatobiliary scanning. The corresponding values for infusion tomography were 87% and 33%, respectively. It is concluded from these results that ultrasonography and sup(99m)Tc-DIDA hepatobiliary scanning are capable of establishing the diagnosis rapidly and with certainty in cases of suspected acute cholecystitis. A preliminary account of the results of routine employment of sup(99m)Tc-DIDA hepatobiliary scanning in 29 consecutive patients revealed no erroneous diagnoses. In the majority of patients with acute cholecystitis, operation proved possible within 48 hours of admission.

Cholecystokinin cholescintigraphic findings in the cystic duct syndrome

International Nuclear Information System (INIS)

Fink-Bennett, D.; DeRidder, P.; Kolozsi, W.; Gordon, R.; Rapp, J.

1985-01-01

Fourteen patients with a cystic duct syndrome (CDS) underwent cholecystokinin (CCK) cholescintigraphy. All patients presented with persistent postprandial right upper quadrant pain and biliary colic. None of the patients had an abnormal oral cholecystography, gallbladder (GB) ultrasound exam or upper GI series. Each patient received 5 mCi of technetium-99m disofenin. When the GB maximally filled, 0.02 microgram/kg CCK was administered (3 min) intravenously. Background corrected gallbladder ejection fractions (GBEFs) were determined every 5 min X 4 by rationing the pre-CCK GB counts minus post-CCK GB counts to pre-CCK GB counts. GBEFs were: 12% (3 patients), 17% (2), 0%, 1.3%, 3%, 4%, 6%, 11%, 14%, 18.5%, and 22% (1 each). All patients underwent a surgical exploration and all had macro- or microscopically abnormal cystic ducts with (12 patients) or without (2 patients) concomitant chronic cholecystitis. No patient with a partially occluded cystic duct with or without concomitant chronic cholecystitis had an ejection fraction that exceeded 22%. In an appropriate clinical setting, a low EF response to CCK should alert the physician to the presence of either chronic acalculous cholecystitis, CDS, or the combination of both

Medical radiation exposure and usage for diagnostic radiology in Malaysia

International Nuclear Information System (INIS)

Ng, Kwan-Hoong; Rassiah, Premavathy; Abdullah, B.J.J.; Wang, Hwee-Beng; Shariff Hambali, Ahmad; Muthuvelu, Pirunthavany; Sivalingam, S.

2001-01-01

A national dose survey of routine X-ray examinations in Malaysia (a Level II country) from 1993 to 1995 had established baseline data for seven common types of x-ray examinations. A total of 12 randomly selected public hospitals and 867 patients were included in this survey. Survey results are generally comparable with those reported in the UK, USA and IAEA. The findings support the importance of the ongoing national quality assurance programme to ensure doses are kept to a level consistent with optimum image quality. The data was useful in the formulation of national guidance levels as recommended by the IAEA. The medical radiation exposure and usage for diagnostic radiology (1990-1994) enabled a comparison to be made for the first time with the UNSCEAR 2000 Report. In 1994, the number of physicians, radiologists, x-ray units and x-ray examinations per 1000 population was 0.45, 0.005, 0.065 and 183, respectively; 3.6 million x-ray examinations were performed; the annual effective dose per capita was 0.05 mSv and collective dose was 1000 person-Sv. Chest examinations contributed 63% of the total. Almost all examinations experienced increasing frequency except for barium studies, cholecystography, and intravenous urography (-23%, -36%, -51%). Notable increases were observed in computed tomography (161%), cardiac procedures (190%), and mammography (240%). (author)

Successful topical dissolution of cholesterol gallbladder stones using ethyl propionate.

Science.gov (United States)

Hofmann, A F; Amelsberg, A; Esch, O; Schteingart, C D; Lyche, K; Jinich, H; Vansonnenberg, E; D'Agostino, H B

1997-06-01

Topical dissolution of cholesterol gallbladder stones using methyl tert-butyl ether (MTBE) is useful in symptomatic patients judged too ill for surgery. Previous studies showed that ethyl propionate (EP), a C5 ester, dissolves cholesterol gallstones rapidly in vitro, but differs from MTBE in being eliminated so rapidly by the liver that blood levels remain undetectable. Our aim was to test EP as a topical dissolution agent for cholesterol gallbladder stones. Five high-risk patients underwent topical dissolution of gallbladder stones by EP. In three patients, the solvent was instilled via a cholecystostomy tube placed previously to treat acute cholecystitis; in two patients, a percutaneous transhepatic catheter was placed in the gallbladder electively. Gallstone dissolution was assessed by chromatography, by gravimetry, and by catheter cholecystography. Total dissolution of gallstones was obtained in four patients after 6-10 hr of lavage; in the fifth patient, partial gallstone dissolution facilitated basketing of the stones. In two patients, cholesterol dissolution was measured and averaged 30 mg/min. Side effects were limited to one episode of transient hypotension and pain at the infusion site; no patient developed somnolence or nausea. Gallstone elimination was associated with relief of symptoms. EP is an acceptable alternative to MTBE for topical dissolution of cholesterol gallbladder stones in high-risk patients. The lower volatility and rapid hepatic extraction of EP suggest that it may be preferable to MTBE in this investigational procedure.

Hepatobiliary imaging: a comparison of 99Tcsup(m)-dihydro-thioctic acid and 99Tcsup(m)-pyridoxylidene glutamate in the non-jaundiced patient

International Nuclear Information System (INIS)

Jenner, R.E.; Howard, E.R.; Clarke, M.B.; Barrett, J.J.

1978-01-01

A comparison of two hepatobiliary imaging agents, 99 Tcsup(m)-dihydrothioctic acid ( 99 Tcsup(m)-DHT) and 99 Tcsup(m)-pyridoxylidene glutamate ( 99 Tcsup(m)-PG) has been carried out in 44 non-jaundiced patients. Thirty-one patients were admitted for investigation of upper abdominal pain and 13 patients were volunteers who were undergoing treatment for unrelated conditions. Satisfactory liver images were obtained with both agents in patients without liver disease, but they were inferior to those seen after 99 Tcsup(m)-sulphur colloid. 99 Tcsup(m)-PG produced clearer images of the gall-bladder and bile ducts than 99 Tcsup(m)-DHT. Non-visualization of the gall-bladder was interpreted as gall-bladder disease; in patients with inflammatory gall-bladder disease no gall-bladder image was seen (nine 99 Tcsup(m)-DHT, nine 99 Tcsup(m)-PG). The gall-bladder was also not demonstrated in two of the volunteers' group (one 99 Tcsup(m)-DHT, one 99 Tcsup(m)-PG), nor was a gall-bladder seen in five patients whose abdominal pain was not due to acute cholecystitis. Despite this, there was agreement between the results of imaging and oral cholecystography in 21 out of 22 subjects. 99 Tcsup(m)-PG is non-toxic, cheap and rapidly excreted by the liver into the bile. A 99 Tcsup(m)-PG scan would be useful when rapid diagnosis is required in suspected acute cholecystitis when conventional contrast radiology is unlikely to be of value. (author)

Gall bladder function test with Ceruletid

International Nuclear Information System (INIS)

Schindler, G.

1981-01-01

Compared with the stimulating food given orally in the gall bladder function test the administration of the decapeptide Ceruletid which is related with Cholecystokinin has the advantage of avoiding resorption disturbances in the upper gastrointestinal tract. To 100 patients with positive peroral cholecystography, Ceruletid was injected i.m. in a dose of 0.4 μg/kg body weight. The contrasting of the main bile duct was thus increased from 10% to 86%. The oral stimulating food brings an increase to appr. 20%. A special importance is assigned to the frequent diagnosis of adenomyomatoses which, with 6%, lies significantly above the 0.8% achieved by means of the oral stimulating food. More contractile segments of the gall bladder wall can cause pain symptoms which are typical for the biliary tract. Adenomyomatoses in the region of the infundibulum of the gall bladder cause colicky pains and are, as generally accepted, an absolute indication for a surgical intervention. The finding of small gall bladder conrements is often connected with a strong diminution of the gall bladder in order to prevent the small concrements from being overlapped by the non-contrasting bladder bile. Therefore, the application of Ceruletid should be considered also within the frame of the intravenous cholegraphy, thinking of the large number of normal gall bladder findings which were obtained with the oral stimulating food as the only diagnostical help. (orig./MG) [de

Radiopharmaceuticals for hepatobiliary imaging

International Nuclear Information System (INIS)

Chervu, L.R.; Nunn, A.D.; Loberg, M.D.

1982-01-01

Tests for liver function have by and large centered around clinical laboratory diagnostic procedures for a number of years. Besides these, radiographic imaging procedures, including oral cholecystography and intravenous cholangiography, serve a very useful purpose, but several of them are invasive and involve a certain degree of risk from the administered contrast media as well as discomfort to the patient. The cholescintigraphic procedures, though noninvasive, have not played a significant role in the evaluation of hepatobiliary disorders prior to the introduction of the currently available /sup 99m/Tc-labeled IDAs. These new hepatobiliary agents offer many advantages over the previously utilized radiopharmaceuticals ( 131 I-rose bengal in particular) in terms of the high degree of specificity for localization in the gallbladder with rapid extraction rates by the polygonal cells of the liver and very low excretion via the GU tract. A detailed understanding of the structure distribution relationship of the various groups in the complex enable the design of agents with an improvement in hepatobiliary specificity and other desirable characteristics. In many clinical situations, even in patients with high bilirubin levels, the /sup 99m/Tc-labeled IDAs offer far superior clinical information over the alternative diagnostic imaging modalities. Further, the absorbed radiation dose imparted to the critical organs is far lower than with the older agents. Thus, the introduction of the cholescintigraphic procedures with the /sup 99m/Tc-labeled IDAs have ushered in a new phase in the diagnostic workup of patients with impaired hepatocellular function and other biliary disorders

[Extracorporeal shock-wave lithotripsy of gallstones].

Science.gov (United States)

Freund, H R; Lebensart, P D; Muggia-Sullam, M; Durst, A L

1989-08-01

We performed 16 extracorporeal shock-wave lithotripsies (ESWL) to fragment gallstones in 11 women and 2 men, aged 19 to 57 (mean 41 +/- 10) years, during the past 10 months. Criteria for selection included a history of biliary colic, not more than 3 stones with a total diameter of not more than 30 mm, and a functioning gallbladder. 210 patients were examined, of whom 98 were referred for additional screening by combined ultrasonography and oral cholecystography. This resulted in rejection of another 71 patients due to multiple stones (38%), nonfunctioning gallbladder (22%), calcified stones (12%), stones not visualized in the prone position (9%), excessively large stones (3%) and other reasons (16%). Only 27 patients fulfilled all the criteria. Under epidural or general anesthesia (11 and 2 patients, respectively), we administered 1200-3500 (mean 2250 +/- 750) shock waves at 20-24 KV with the Tripter X1 (Direx, Israel-USA). This is an ultrasound-guided, modular portable, shock-wave generator utilizing underwater high energy spark discharge. Chenodeoxycholic or ursodeoxycholic acid, 10 mg/kg/day, was started 1 week prior to ESWL and continued for 3 months after disappearance of fragments and debris. We encountered skin petechiae in all patients, transient hematuria in 8, mild biliary colic in 1 and a small liver hematoma in 1. To date, 3 patients are free of stones, while in 7 only sludge and tiny fragments are present which we expect to disappear as a result of the litholytic therapy. 3 patients had fragments larger than 5 mm and required a second ESWL. Thus ESWL, which was indicated in only 13% of screened patients, proved to be safe and can be expected to be successful in 75% of selected candidates.

Litiasis única en vesícula doble tratada con ondas de choque extracorpórea Single lithiasis in double gallblader treated with extracorporeal shock waves

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Domingo Pérez González

2004-06-01

Full Text Available La vesícula biliar doble es una anomalía congénita poco frecuente. Su diagnóstico puede realizarse con ultrasonido y colecistografía. Se presenta una paciente de 27 años de edad, con antecedentes de intolerancia a las grasas y cólicos biliares a repetición, con vesícula duplicada; exteriormente fundida y dos conductos císticos independientes que desembocan en el hepatocolécodo, con un cálculo único, de 12 mm de diámetro, retrotransparente y 0 unidades Houndfield, ubicado en el cuello de la vesícula más desarrollada. Se aplicaron 2 259 ondas de choque extracorpóreas de 20,4 kilovoltios, generadas por el principio electromagnético; en una sesión de litroticia. Se detuvo fragmentación completa del cálculo. El tratamiento fue ambulatorio. La paciente se reincorporó a su vida laboral a las 24 horas. Durante la expulsión de los fragmentos tuvo varias crisis de dolor que cedieron con analgésicos orales. A los 6 meses, la vesícula afectada se encontraba libre de fragmentos y funcional. No existió complicación y hasta el momento se mantiene asintomáticaDouble gall bladder is an uncommon congenital abnormality. It may be diagnosed by ultrasound and cholecystography. It is reported the case of a 27-year-old patient with history of intolerance to fats and repeated biliary cholics, with duplicated gallbladder externally fused, and two independent cystic ducts flowing to the hepatocholedoco with a single calculus of 12 mm of diameter, retrotransparent and 0 Houndfield units, located in the neck of the more developed gallbladder. 2 259 extracorporeal shock waves of 20.4 kilovolts generated by the electromagnetic principle were applied in a lithotripsy session. The complete fragmentation of the calculus was stopped. The treatment was ambulatory. The patient reincorporated to her working life at 24 hours. During the expulsion of the fragments, she had several pain crises that were resolved with oral analgesics. Six months later, the

A radiological study on the effect of postural changes after far meal on contraction of the gallbladder

International Nuclear Information System (INIS)

Choi, Il Bong; Park, Seog Hee; Yim, Jeong Ik; Kim, Jong Woo; Bahk, Yong Whee

1982-01-01

Oral cholecystography is one of the most reliable and widely used x-ray examination which enables us to observed not only morphological features of the gallbladder (GB) but also functioning state. It was disclosed that functional evaluation of the GB is mandatory to recognize such kinetic disorders of the viscus as acalculous cholecystitis or dyskinesia. For the purpose of functional evaluation, fat meal has been used traditionally. Recently, cholecystokinin (CCK) and ceruletide were introduced into clinical diagnosis of the GB, the usefulness of which we have confirmed. In the present study we have made an attempt at improving cholecystagogic effect of conventional fat meals(FM) such as whole milk and egg yolk by changing the posture of the examined from sitting up to right decubitus position after the ingestion of fat meal. The hypothesis involved in this study is that the presence of quantitatively more fat meal in the duodenum per unit time may result in more effective cholecystagogic action and such a setting would be created by enhancement of pyloric passage of fat meal by decubitus posturing. Clinical materials consisted of 280 normal oral GB series (136 males and 144 females) and they were divided into 4 equally numbered groups of milk sitting and milk decubitus and egg sitting and egg decubitus. Upon confirming satisfactory opacification of the GB 11 hours after the ingestion of 3 g of sodium ipodate or iopanoic acid either 2 pieces of medium sized hen's egg yolk were given. The xaminess were than allowed either sitting up comfortably on a bench or lying down on the right flank on a couch. After the ingestion of fat mean, x-ray was taken at the end of 30 minutes in all but the milk decubitus group in which x-rays were taken serially at the end of 5, 15, 30 and 60 minutes. The frontal area of each opacified GB was measured by using a planimeter and the contraction rate before and after fat meal stimulation was calculated by the following equation and

A radiological study on the effect of postural changes after far meal on contraction of the gallbladder

Energy Technology Data Exchange (ETDEWEB)

Choi, Il Bong; Park, Seog Hee; Yim, Jeong Ik; Kim, Jong Woo; Bahk, Yong Whee [Catholic Medical College, Seoul (Korea, Republic of)

1982-06-15

Oral cholecystography is one of the most reliable and widely used x-ray examination which enables us to observed not only morphological features of the gallbladder (GB) but also functioning state. It was disclosed that functional evaluation of the GB is mandatory to recognize such kinetic disorders of the viscus as acalculous cholecystitis or dyskinesia. For the purpose of functional evaluation, fat meal has been used traditionally. Recently, cholecystokinin (CCK) and ceruletide were introduced into clinical diagnosis of the GB, the usefulness of which we have confirmed. In the present study we have made an attempt at improving cholecystagogic effect of conventional fat meals(FM) such as whole milk and egg yolk by changing the posture of the examined from sitting up to right decubitus position after the ingestion of fat meal. The hypothesis involved in this study is that the presence of quantitatively more fat meal in the duodenum per unit time may result in more effective cholecystagogic action and such a setting would be created by enhancement of pyloric passage of fat meal by decubitus posturing. Clinical materials consisted of 280 normal oral GB series (136 males and 144 females) and they were divided into 4 equally numbered groups of milk sitting and milk decubitus and egg sitting and egg decubitus. Upon confirming satisfactory opacification of the GB 11 hours after the ingestion of 3 g of sodium ipodate or iopanoic acid either 2 pieces of medium sized hen's egg yolk were given. The xaminess were than allowed either sitting up comfortably on a bench or lying down on the right flank on a couch. After the ingestion of fat mean, x-ray was taken at the end of 30 minutes in all but the milk decubitus group in which x-rays were taken serially at the end of 5, 15, 30 and 60 minutes. The frontal area of each opacified GB was measured by using a planimeter and the contraction rate before and after fat meal stimulation was calculated by the following equation and

Cholecystokinetic cholecysto-choledochography

Energy Technology Data Exchange (ETDEWEB)

Park, Han Kyu; Bahk, Yong Whee [Catholic Medical College, Seoul (Korea, Republic of)

1980-12-15

Oral cholecystography is a reliable and the most popular clinical examination. The examinations is not suitable for morphological study of the gallbladder but also efficient in diagnosing acalculous cholecystitis and cystic duct syndrome and some ill defined functional disorders. For the functional evaluation of the gallbladder fat meal stimulation has been used traditionally. Recently, however, potent cholecystagogues called cholecystokinin (CCK) and ceruletide were introduced in the radiological examination of the gallbladder stimulating acute interest in research of acalculous cholecystitis and cystic duct syndrome. The present study has been undertaken to test both experimentally and clinically the cholecystokinetic effects of CCK and ceruletide. In addition, the study has been designed to test if pharmacological constriction of the Oddi sphincter with morphine in animal and prostigmine in human subjects promotes visualization of the common bile duct and hopefully the common hepatic duct. Seen (7) mongrel dogs weighing 10 kg were anesthesized with Pentothal sodium (20mg/kg body wt) in the evening allowed to swallow 2 g of lopanoic acid (Telepaque) per os. Twelve hours later in the next morning dogs were radiographed of their upper abdomen in LAO. Upon confirming optimal opacification of the GB 0.03 {mu} g/kg of CCK was injected intravenously to each of the 7 mongrel dogs for the test of contraction-rate and contraction-time of the gallbladder. The same test was repeated after injecting 10 mg/dog of morphine to strict the Oddi sphincter. The clinical materials consisted of 30 normal human subjects and 60 patients with biliary symptoms and signs. Those with abnormal upper gastrointestinal series and abnormal function tests of the pancreas were excluded from the materials. We injected the same amount of CCK and studied the contraction rate and time with an emphasis on acalculous cholecystitis and cystic duct syndrome and some ill-defined functional disorder. In

Cholecystokinetic cholecysto-choledochography

International Nuclear Information System (INIS)

Park, Han Kyu; Bahk, Yong Whee

1980-01-01

Oral cholecystography is a reliable and the most popular clinical examination. The examinations is not suitable for morphological study of the gallbladder but also efficient in diagnosing acalculous cholecystitis and cystic duct syndrome and some ill defined functional disorders. For the functional evaluation of the gallbladder fat meal stimulation has been used traditionally. Recently, however, potent cholecystagogues called cholecystokinin (CCK) and ceruletide were introduced in the radiological examination of the gallbladder stimulating acute interest in research of acalculous cholecystitis and cystic duct syndrome. The present study has been undertaken to test both experimentally and clinically the cholecystokinetic effects of CCK and ceruletide. In addition, the study has been designed to test if pharmacological constriction of the Oddi sphincter with morphine in animal and prostigmine in human subjects promotes visualization of the common bile duct and hopefully the common hepatic duct. Seen (7) mongrel dogs weighing 10 kg were anesthesized with Pentothal sodium (20mg/kg body wt) in the evening allowed to swallow 2 g of lopanoic acid (Telepaque) per os. Twelve hours later in the next morning dogs were radiographed of their upper abdomen in LAO. Upon confirming optimal opacification of the GB 0.03 μ g/kg of CCK was injected intravenously to each of the 7 mongrel dogs for the test of contraction-rate and contraction-time of the gallbladder. The same test was repeated after injecting 10 mg/dog of morphine to strict the Oddi sphincter. The clinical materials consisted of 30 normal human subjects and 60 patients with biliary symptoms and signs. Those with abnormal upper gastrointestinal series and abnormal function tests of the pancreas were excluded from the materials. We injected the same amount of CCK and studied the contraction rate and time with an emphasis on acalculous cholecystitis and cystic duct syndrome and some ill-defined functional disorder. In

Surgical treatment of gallbladder polypoid lesions

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Pejić Miljko A.

2003-01-01

Full Text Available INTRODUCTION Polypoid lesions of the gallbladder can be divided into benign and malignant categories. Malignant polypoid lesions include carcinomas of the gallbladder, which is the fifth most common malignancy of the gastrointestinal tract and the most common malignancy of the biliary tract. Benign polypoid lesions of the gallbladder are divided into true tumors and pseudotumors. Pseudotumors account for most of polypoid lesions of the gallbladder, and include polyps, hyperplasia, and other miscellaneous lesions. Adenomas are the most common benign neoplasms of the gallbladder. Cholesterol polyps are the most common pseudotumors of the gallbladder. The polyps can be single or multiple, usually less than 10 mm in size. They have no predilection for any particular gallbladder site, and usually are attached to the gallbladder wall by a delicate, narrow pedicle. No malignant potential has been identified for this type of pseudotumor. Adenomas are the most common benign neoplasms of the gallbladder. They have no predilection site in the gallbladder, and may also be associated with gallstones or cholecystitis. The premalignant nature of adenomas remains controversial. Ultrasonography (US has been demonstrated to be significantly better in detecting polypoid lesions of the gallbladder as compared with computed tomography and cholecystography. A mass fixed to the gallbladder wall of normal thickness, without shadowing, is seen in case of gallbladder polyp. Since gallbladder cancers usually present as polypoid lesions, differentiation between benign polypoid lesion and malignant lesion can be very difficult, even with high-resolution imaging techniques. PATIENTS AND METHODS Retrospectively we have analyzed 38 patients with ultrasonographicaly detected gallbladder polyps during the period from January 1995 to December 2000, who were treated at surgical department of Health Centre in Uzice and at Surgical clinic of Clinical Centre in Nis. We have analyzed