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Sample records for chinese herbal formulae

  1. Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparation

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    Bensoussan Alan

    2010-02-01

    Full Text Available Abstract Background The employment of well characterized test samples prepared from authenticated, high quality medicinal plant materials is key to reproducible herbal research. The present study aims to demonstrate a quality assurance program covering the acquisition, botanical validation, chemical standardization and good manufacturing practices (GMP production of IBS-20, a 20-herb Chinese herbal formula under study as a potential agent for the treatment of irritable bowel syndrome. Methods Purity and contaminant tests for the presence of toxic metals, pesticide residues, mycotoxins and microorganisms were performed. Qualitative chemical fingerprint analysis and quantitation of marker compounds of the herbs, as well as that of the IBS-20 formula was carried out with high-performance liquid chromatography (HPLC. Extraction and manufacture of the 20-herb formula were carried out under GMP. Chemical standardization was performed with liquid chromatography-mass spectrometry (LC-MS analysis. Stability of the formula was monitored with HPLC in real time. Results Quality component herbs, purchased from a GMP supplier were botanically and chemically authenticated and quantitative HPLC profiles (fingerprints of each component herb and of the composite formula were established. An aqueous extract of the mixture of the 20 herbs was prepared and formulated into IBS-20, which was chemically standardized by LC-MS, with 20 chemical compounds serving as reference markers. The stability of the formula was monitored and shown to be stable at room temperature. Conclusion A quality assurance program has been developed for the preparation of a standardized 20-herb formulation for use in the clinical studies for the treatment of irritable bowel syndrome (IBS. The procedures developed in the present study will serve as a protocol for other poly-herbal Chinese medicine studies.

  2. The effects of two Chinese herbal medicinal formulae vs. placebo controls for treatment of allergic rhinitis: a randomised controlled trial

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    Chan, Rose YP; Chien, Wai Tong

    2014-01-01

    Background Allergic rhinitis is a chronic illness, affecting 10 to 40% of the worldwide population. Chinese herbal medicines, the treatment of allergic rhinitis, adopted thousands of years in ancient China, has recently raised much attention among researchers globally. This study evaluates the effects of two Chinese herbal formulae [Cure-allergic-rhinitis Syrup (CS) and Yu-ping-feng San (YS)] in treating undergraduate nursing students with allergic rhinitis over a 3-month follow-up, when comp...

  3. Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

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    Jiangang Liu

    2014-01-01

    Full Text Available The aim of this study was to evaluate the anti-inflammatory profiling of the Chinese herbal formula Sini Tang (SNT in myocardial infarction (MI rats. SNT, a decoction consisting of four herbs: Aconitum carmichaelii, Cinnamomum cassia, Zingiber officinale, and Glycyrrhiza uralensis, was characterized as a remedy to treat syndromes corresponding to heart failure and MI in China. Potential biomarkers, which reflect the extent of myocardial necrosis and correlate with cardiac outcomes following MI, such as atrial natriuretic peptide (ANP, high sensitivity C-reactive protein (hs-CRP, and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and interleukin-1β (TNF-α, IL-6, and IL-1β were determined in plasma, serum, and in myocardial tissue of MI rats after treatment with SNT. Our data indicate that SNT decreased significantly the levels of hs-CRP, TNF-α, IL-6, and IL-1β in MI rats. SNT decreased the expression of ANP levels in plasma and increased the vascular active marker nitric oxide, which limits vascular inflammation. In addition, SNT could decrease the expression of endothelin-1 levels in rat plasma post-MI. Our data suggest that the Chinese herbal formula SNT has the potential to improve cardiac function after MI. SNT may be a candidate for treating MI and its associated inflammatory responses.

  4. Effectiveness and Safety of Manufactured Chinese Herbal Formula for Knee Osteoarthritis: Insights from a Systematic Review

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    Liguo Zhu

    2015-01-01

    Full Text Available Objective. To assess the current clinical evidence of manufactured Chinese herbal formulae (MCHF for knee osteoarthritis (KOA. Methods. Seven databases were searched from inception to May 2015. Eligible randomized controlled trials investigating the effectiveness of MCHF for KOA were included. Data extraction, methodological assessment, and meta-analyses were conducted according to the Cochrane standards. Results. A total of 17 kinds of MCHF were identified from the twenty-six included trials. Meta-analyses showed that MCHF significantly relieved the global pain of knee joints, either used alone or combined with routine treatments. Additionally, MCHF plus routine treatments significantly decreased the scores of WOMAC and Lequesne index. However, there were no statistical differences between MCHF group and routine treatment group in walk-related pain and WOMAC scores. No significant differences were found in Lysholm scores. There were twenty-one trials that mentioned adverse events. A pooled analysis showed that adverse events occurred more frequently in control group compared with MCHF group. Conclusions. Our results indicated that MCHF showed some potential benefits for KOA. However, we still cannot draw firm conclusions due to the poor methodological quality of included trials. More high-quality RCTs would help to confirm the evidence.

  5. Effects of Chinese herbal formula Heat-stress-releasing on antioxidant function in dairy cows

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    ZHANG Qingru; NI Yaodi; GUO Hongbin; WANG Chunguang

    2007-01-01

    In order to investigate the effects of a Chinese herbal formula Heat-stress-releasing on the antioxidant function in dairy cows,ten dairy cows were randomly divided into the control group and the experimental group,with five cows in each group.All the cows were fed with a basal diet.The animals in the experimental group were given with 220 g of herbs per day in addition to the basal diet.The trial was conducted for 14 days.Blood samples were taken from the vena cava at day 0,day 7,and day 15,respectively.The antioxidant statuses were examined.The results are as follows.(1) Heat-Stress-releasing formula can significantly increase the milk yield of dairy cows under heat stress.Compared with the control group,the milk yield of the herb-treated group increased by 14.01% (P<0.05),14.32% (P<0.05) and 15.01% (P<0.05) in prophase,metaphase and anaphase of the test,respectively.(2) Heat-Stress-releasing formula can increase significantly the antioxidant status of the heat stressed dairy cows.Compared with the control group,the superoxide dismutase (SOD) activity increased by 45.93% (P<0.01) at day 7 and by 54.40% (P<0.01) at day 15.The Glutathione-peroxidase (GSH-PX) activity of the test group increased by 17.99% (P<0.05) at day 7 and 25.98% (P<0.01) at day 15.The total antioxidant capacity (T-AOC) of the test group increased by 43.64% (P<0.01) at day 7 and 46.35% (P<0.01)at day 15.The malondaldehyd (MDA) content of test group declined by 23.88% (P<0.01) at day 7 and 25.32% (P<0.01)at day 15.

  6. Antidiarrheal properties of different extracts of Chinese herbal medicine formula Bao-Xie-Ning

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    Jing Li; Xin-lin Wu; Yuling Chen; Zhi Tang; Yue-hong Xu; Jian-min Jiang; Yue-yu Gu

    2013-01-01

    OBJECTIVE:Bao-Xie-Ning (BXN),a traditional Chinese herbal medicine (CHM) formula composed of Fructus Evodiae,Flos Caryophylli and Cortex Cinnamomi,and used for the treatment of infant diarrheal illness,was subject to systematic assessment for its putative multiple pharmacodynamic effects and pharmacological antidiarrheal mechanisms.METHODS:High-performance liquid chromatography-diode array detector-electrospray ionizationmass spectrometric/mass spectrometry was developed and validated for identification and quantification of the main constituents in different extracts of BXN.Male Kunming mice weighing 20 to 25 g were used for detecting the antidiarrheal activity of the extracts.Ethanolic extract (EE),volatile oil extract (VOE),and aqueous extract (AE) of BXN were respectively subjected to pharmacodynamic and pharmacological comparison in assessing antidiarrheal effects with senna-induced diarrhea,castor oil-induced diarrhea,acetic acid-induced writhing assay,and isolated duodenum test.RESULTS:The highest yields of three detected components of BXN,rutaecarpine,eugenol and cinnamaldehyde were observed in EE.EE showed the most remarkable antidiarrheal activity in dose-dependent and time-dependent manners in both senna-and castor oil-induced diarrhea models,and presented dose-dependent analgesic activity in acetic acid-induced algesthesia model.In addition,EE extract of BXN also exhibited strong antimobility action on the intestine and strongest depression on spontaneous contraction of isolated duodenum.CONCLUSION:Ethanol extraction is an efficient method to extract the active constituents of BXN.BXN extract demonstrated multiple pharmacological activities affecting the main mechanisms of diarrhea,which validated BXN's usage in the comprehensive clinical treatment of diarrhea.

  7. Effect of a Chinese herbal formula Astragalus immunomodulator on immune function of chickens

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    Qingru ZHANG; Guojun JIANG; Shupeng LI; Xiuhui ZHONG

    2009-01-01

    In order to investigate the immunomodulatory effects and the mechanism of a Chinese herbal medicine, Zengmiansan (Astragalus immunomodulator), on immune function of chickens, three hundred 1-day-old chickens were assigned randomly into 5 groups, i.e., the blank control group, the Chinese herbal medicine Zengmiansan (ZMS)-treated group, the cyclophosphamide group, the cyclophosphamide plus levamisole group, the cyclophosphamide plus ZMS group and the control group. All chickens were immunized with Lasota vaccine by nose-drip or eye-drop at the age of 6 days. Newcastle Disease (ND) antibody titers, growth indexes of the spleen, thymus and bursa of Fabricius, the concentrations of CD4+ lymphocytes and CD8+ lymphocytes in spleen, thymus and peripheral blood, and the apoptosis of splenocytes, thymocytes and bursa of Fabricius cells were observed at the ages of 14,21, 28 and 35 days, respectively. Our results indicated that the NDV antibody titers of chickens in the Chinese herbal medicine ZMS-treated group at the ages of 14 and 21 days were significantly higher than that of the other groups (P<0.01). The growth indexes of immune organs, the concentrations of CD4+ lymphocytes and the ratio of CD4+/CD8+ T lymphocytes of chickens in the Chinese herbal medicine ZMS- treated group at the ages of 14, 21 and 28 d were significantly higher than those of the other groups (P<0.01). The apoptotic splenocytes, thymocytes and bursa of Fabricius cells of chickens in the ZMS-treated group were significantly lower than the other groups (P < 0.01) at the ages of 14, 21 and 28 days.

  8. Liuwei Dihuang, a traditional Chinese herbal formula, suppresses chronic inflammation and oxidative stress in obese rats

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    Benjamin Perry; Junzeng Zhang; Tarek Saleh; Yanwen Wang

    2014-01-01

    OBJECTIVE:To investigate the anti-inlfammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang (LWDH), a traditional Chinese herbal formula, in obese rats. METHODS:After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived (OP-CD) rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water (n=12 rats per group). Twelve obese-resistant-CD (OR-CD) rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacriifce and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS:After 9 weeks of treatment, LWDH lowered serum C-reactive protein (CRP) and tumour necrosis factor-α (TNF-α) levels. Serum interleukin-6 (IL-6) levels showed a tendency towards reduction, but were not signiifcantly different from the OP-CD control. Liver superoxide dismutase (SOD) activity was increased in response to all three doses of LWDH, while the levels of reduced (GSH) and oxidized glutathione (GSSG) and thiobarbituric acid reactive substances (TBARS) were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inlfammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION: The results show, for the ifrst time, the anti-inlfammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OR/OP-CD rat model as a

  9. Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology.

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    Lixia Pei

    Full Text Available The clinical application of Traditional Chinese medicine (TCM, using several herbs in combination (called formulas, has a history of more than one thousand years. However, the bioactive compounds that account for their therapeutic effects remain unclear. We hypothesized that the material basis of a formula are those compounds with a high content in the decoction that are maintained at a certain level in the system circulation. Network pharmacology provides new methodological insights for complicated system studies. In this study, we propose combining pharmacokinetic (PK analysis with network pharmacology to explore the material basis of TCM formulas as exemplified by the Bushen Zhuanggu formula (BZ composed of Psoralea corylifolia L., Aconitum carmichaeli Debx., and Cnidium monnieri (L. Cuss. A sensitive and credible liquid chromatography tandem mass spectrometry (LC-MS/MS method was established for the simultaneous determination of 15 compounds present in the three herbs. The concentrations of these compounds in the BZ decoction and in rat plasma after oral BZ administration were determined. Up to 12 compounds were detected in the BZ decoction, but only 5 could be analyzed using PK parameters. Combined PK results, network pharmacology analysis revealed that 4 compounds might serve as the material basis for BZ. We concluded that a sensitive, reliable, and suitable LC-MS/MS method for both the composition and pharmacokinetic study of BZ has been established. The combination of PK with network pharmacology might be a potent method for exploring the material basis of TCM formulas.

  10. TRADITIONAL CHINESE HERBAL MEDICINE

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    ZHU, YP; WOERDENBAG, HJ

    1995-01-01

    Herbal medicine, acupuncture and moxibustion, and massage and the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the mos important part of traditional Chinese medicine, is less well known in the We

  11. Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: a randomized, placebo-controlled trial

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    Yi Chen; De-yu Fu; Yu Chen; Yan-ming He; Xiao-dong Fu; Yan-qiu Xu; Yi Liu

    2013-01-01

    BACKGROUND:Patients with hypertension coupled with metabolic syndrome (MetS) are among the high risk population in cardiovascular and cerebrovascular diseases.To reduce the prevalence of cardiovascular and cerebrovascular diseases,it is essential to appropriately control blood pressure together with other cardiovascular risk factors.OBJECTIVE:The current study was designed to investigate the therapeutic effects on blood pressure,blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula,a compound traditional Chinese herbal medicine,in addition to routine treatment to hypertensive patients coupled with MetS.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:A total of 43 patients with hypertension coupled with MetS were recruited into this study.The enrolled patients were randomly divided into the Chinese herbal formula group (anti-hypertensive drugs plus Yiqi Huaju Formula,CHF) and the control group (anti-hypertensive drugs plus placebo).The CHF group enrolled 22 patients while the control group received 21 cases.Treatments were given for 12 weeks in both groups.MAIN OUTCOME MEASURES:Parameters examined include 24-hour ambulatory blood pressure monitoring,body mass index,waist circumference,waist-to-hip ratio,homeostatic model assessment for insulin resistance (HOMA-IR),fasting glycosylated hemoglobin (HbA1c),fasting plasma glucose,2-hour postprandial plasma glucose (PPG),fasting plasma insulin,serum lipid,etc.RESULTS:Compared with the control group,the CHF group had significant improvement (P<0.01) in anthropometric parameters,FPG,HOMA-IR,blood pressure amplitude,blood pressure variability and blood pressure load.CONCLUSION:This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors.The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi

  12. Inhibition of release of inflammatory mediators in primary and cultured cells by a Chinese herbal medicine formula for allergic rhinitis

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    McPhee Sarah

    2007-02-01

    Full Text Available Abstract Background We demonstrated that a Chinese herbal formula, which we refer to as RCM-101, developed from a traditional Chinese medicine formula, reduced nasal and non-nasal symptoms of seasonal allergic rhinitis (SAR. The present study in primary and cultured cells was undertaken to investigate the effects of RCM-101 on the production/release of inflammatory mediators known to be involved in SAR. Methods Compound 48/80-induced histamine release was studied in rat peritoneal mast cells. Production of leukotriene B4 induced by the calcium ionophore A23187 was studied in porcine neutrophils using an HPLC assay and lipopolysaccharide-stimulated prostaglandin E2 production was studied in murine macrophage (Raw 264.7 cells by immune-enzyme assay. Expression of cyclooxygenase-1 (COX-1 and cyclooxygenase-2 (COX-2 was determined in Raw 264.7 cells, using western blotting techniques. Results RCM-101 (1–100 μg/mL produced concentration-dependent inhibition of compound 48/80-induced histamine release from rat peritoneal mast cells and of lipopolysaccharide-stimulated prostaglandin E2 release from Raw 264.7 cells. Over the range 1 – 10 μg/mL, it inhibited A23187-induced leukotriene B4 production in porcine neutrophils. In addition, RCM-101 (100 μg/mL inhibited the expression of COX-2 protein but did not affect that of COX-1. Conclusion The findings indicate that RCM-101 inhibits the release and/or synthesis of histamine, leukotriene B4 and prostaglandin E2 in cultured cells. These interactions of RCM-101 with multiple inflammatory mediators are likely to be related to its ability to reduce symptoms of allergic rhinitis.

  13. Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial

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    Wang, Genfa; Liu, Baojun; Cao, Yuxue; Du, Yijie; Zhang, Hongying; Luo, Qingli; Li, Bei; Wu, Jinfeng; Lv, Yubao; Sun, Jing; Jin, Hualiang; Wei, Kai; Zhao, Zhengxiao; Kong, Lingwen; Zhou, Xianmei

    2014-01-01

    Objective The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD. Methods A multicenter, double-blind, double-dummy, and randomized controlled trial (RCT) was conducted. All groups were treated with additional conventional medicines. There were a 6-month treatment and a 12-month follow-up for 5 times. Primary outcomes included lung function test, exacerbation frequency, score of SGRQ. Second outcomes consisted of 6MWD, BODE index, ps...

  14. Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

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    Peiman Alesheikh

    2015-01-01

    Full Text Available The Chinese herbal formula Tongluo Jiunao, containing the active components Panax notoginseng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control (Xuesai Tong, containing Panax notoginseng or saline intraperitoneally to investigate the pathway involved in the action of Tongluo Jiunao injection. 2,3,5-Triphenyltetrazolium chloride (TTC staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo Jiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo Jiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/tropomyosin-related kinase C pathway.

  15. 自组方1号的毒理学安全性评价%Toxicology and Safety Assessment of Chinese Herbal Formula 1

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    马红

    2011-01-01

    Objective: To evaluate and study the toxicological safety of Chinese Herbal Formula I.Methods: Used the acute toxicity test in mice, Ames test, micronuclei test of bone marrow cell, sperm shape abnormality test in mice and 30 days feeding test in rats. Results: The Chinese Herbal Formula I with the dose of MTD>15000mg/kg showed to be non-toxic on the mice. All three genetic toxicity tests had negative results. Abnormal phenomena were not found in 30 days feeding test. Conclusion: The Chinese Herbal Formula I is safe to use.%目的:评价自组方1号的安全性.方法:依据毒理学评价程序和方法进行急性毒性试验、骨髓细胞微核试验、精子崎形试验、Ames试验和30天喂养试验.结果:小鼠经口MTD> 15000mg/kg,属无毒物;骨髓细胞微核试验、精子崎形试验和Ames试验结果均为阴性;30天喂养试验中各项指标均未见异常.结论:在该试验条件下,自组方1号是安全的.

  16. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis

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    Chun-Hay Ko

    2012-01-01

    Full Text Available Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD loss in postmenopausal women. However, long-term treatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies. Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats. To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment. Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks. From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P=0.014 and 5.94% (0.25 mg/kg/day of raloxifene; P=0.026 when compared with the respective dosage groups with raloxifene alone. Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day; P=0.001 and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P=0.02. However, such interactions could not be observed in all alendronate-treated groups. Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.

  17. Source attribution and structure classification-assisted strategy for comprehensively profiling Chinese herbal formula: Ganmaoling granule as a case.

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    Chen, Jinfeng; Shi, Ziyi; Song, Yuelin; Guo, Xiaoyu; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong

    2016-09-16

    Chinese herbal formula (CHF) has extremely complex chemical composition. Herein, a source attribution and structure classification-assisted strategy was established based on reductionism for rapidly and comprehensively profiling CHF, and Ganmaoling granule (GMLG) was selected as a representative case to illustrate such a strategy and to confirm its applicability. Firstly, comprehensive data acquisition was achieved using neutral losses along with full scan on a liquid chromatography coupled with hybrid ion trap-time of flight mass spectrometer (LC-IT-TOF-MS). Then, the detected precursor and product ions were paired to construct a list of ion transitions for profiling GMLG and its constituent herbs using the scheduled multiple reaction monitoring (sMRM) mode on a LC coupled with hybrid triple quadrupole-linear ion trap mass spectrometer (LC-Q-Trap-MS). The mass parameters of sMRM were optimized using an online optimization strategy to achieve the highest sensitivity, and the automated source attribution was performed with the assistant of the "Quantitate" function of Analyst software. The target peaks were then structurally classified into seven classes through integrating the mass defect filtering (MDF) and diagnostic fragment ion filtering (DFIF), and identified by combination of the mass fragmentation rules and a 'structure extension' approach. Using this strategy, 261 components, including 148 trace ones (with the intensity lower than 100,000 cps), were tentatively characterized. The findings demonstrated that such a comprehensive source attribution and structure classification-assisted strategy is qualified to be an efficient approach for rapidly and globally characterizing the chemical profile of CHF.

  18. Neuroprotective effect of the traditional Chinese herbal formulaTongxinluo:a PET imaging study in rats

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    Xiao Cheng; Haoxuan Luo; Lihua Zhou; Lixin Wang; Jingbo Sun; Yan Huang; Enli Luo; Yefeng Cai

    2014-01-01

    Tongxinluo has been widely used in China for the treatment of acute stroke and for neu-roprotection. However, there are few positron emission tomography (PET) studies on the neuroprotective effect ofTongxinluo on cerebral ischemia/reperfusion in small animals. In the present study,Tongxinluosuperfine powder suspension or its vehicle was administered intragastrically to rats for 5 successive days before middle cerebral artery occlusion.18F-lfuo-rodeoxyglucose (FDG) small animal PET imaging showed that at 1 and 2 weeks after cerebral ischemia/reperfusion, glucose metabolism in the ischemic area was greater in rats that had receivedTongxinluo than in those that had received the vehicle. Nissl staining showed that 2 weeks after cerebral ischemia/reperfusion, there was less neuronal loss in the prefrontal cortex in Tongxinluo-treated rats than in controls. In addition,Tongxinluo-treated animals showed better neurologic function and lower cerebral infarct volume than rats that received the vehicle. These findings suggest thatTongxinluo exhibits neuroprotective effects in cerebral ischemia/reper-fusion injury and demonstrates that18F-FDG small animal PET imaging is a useful tool with which to study the molecular pharmacology of traditional Chinese medicine.

  19. Bioactivity of five components of Chinese herbal formula Jiangzhi granules against hepatocellular steatosis

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    Hai-yan Song; Li Zhang; Jie-lu Pan; Li-li Yang; Guang Ji

    2013-01-01

    OBJECTIVE:This study aims to evaluate the bioactivity of five components of the traditional Chinese medicine complex prescription Jiangzhi granules against hepatocellular steatosis.METHODS:The five major components,including protopanaxadiol,tanshinone IIA,emodin,chlorogenic acid,and nuciferine,were extracted from Jiangzhi granules.Their cytotoxicity was assessed to determine the safe dose of each component for HepG2 cells.HepG2 cellular steatosis was induced using 1 mmol/L of free fatty acids (FFAs) for 24 h,and then treated with each component at high,intermediate,and low doses (500,50,and 5 μmol/L),respectively for another 24 h.The effects on HepG2 steatosis were observed directly under optical phase microscopy,or through oil red O staining and Nile red assays.In addition,the levels of reactive oxygen species (ROS) in the steatotic HepG2 cells with and without high-dose protopanaxadiol treatment were measured using fluorescent dye 2′,7′-dichlorodihydrofluorescein diacetate staining.RESULTS:No obvious cytotoxicity was observed in the HepG2 cells incubated with each of the five components at up to 500 μmol/L.At 24 h after incubation with FFAs,the HepG2 cells swelled and many lipid droplets accumulated.The lipid content was attenuated after 24 h of incubation with protopanaxadiol,tanshinone IIA,and emodin at 500 or 50 μmol/L (P < 0.05),especially with 500 μmol/L protopanaxadiol (P < 0.01).In addition,the ROS level was elevated in steatotic cells,but decreased after intervention with 500 μmol/L protopanaxadiol (P < 0.05).CONCLUSION:Protopanaxadiol,tanshinone IIA,and emodin alleviate hepatocellular steatosis in a dose-dependent manner,and oxidative stress regulation may partially contribute to the effects of protopanaxadiol.

  20. Erxian Tang(二仙汤)——Introduction of a Chinese Herbal Formula,Clinical Practice,and Experimental Studies

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    LI Jie-jia; LI Jack Thomas; FU Jian-ping

    2007-01-01

    Erxian Tang(二仙汤,EXT)is a Chinese herbal formula developed for the treatment of menopausal syndrome in women.In the past 50 years,EXT has shown positive efficacy in the treatment of many chronic diseases in TCM,involving syndrome types of Shen (肾) yin-yang deficiency,yin-deficiency caused yang-flourishing,and disharmony of Chong-Ren meridian.Experimental studies have revealed that EXT has multiple pharmacological actions on such multipie targets as hypothalamus-pituitary-target gland axis,immune function and free radical metabolism,etc.

  1. A randomised placebo-controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea.

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    Lan Lan Liang Yeh

    Full Text Available BACKGROUND: Most traditional Chinese herbal formulas consist of at least four herbs. Four-Agents-Decoction (Si Wu Tang is a documented eight hundred year old formula containing four herbs and has been widely used to relieve menstrual discomfort in Taiwan. However, no specific effect had been systematically evaluated. We applied Western methodology to assess its effectiveness and safety for primary dysmenorrhoea and to evaluate the compliance and feasibility for a future trial. METHODOLOGY/PRINCIPAL FINDINGS: A randomised, double-blind, placebo-controlled, pilot clinical trial was conducted in an ad hoc clinic setting at a teaching hospital in Taipei, Taiwan. Seventy-eight primary dysmenorrheic young women were enrolled after 326 women with self-reported menstrual discomfort in the Taipei metropolitan area of Taiwan were screened by a questionnaire and subsequently diagnosed by two gynaecologists concurrently with pelvic ultrasonography. A dosage of 15 odorless capsules daily for five days starting from the onset of bleeding or pain was administered. Participants were followed with two to four cycles for an initial washout interval, one to two baseline cycles, three to four treatment cycles, and three follow-up cycles. Study outcome was pain intensity measured by using unmarked horizontal visual analog pain scale in an online daily diary submitted directly by the participants for 5 days starting from the onset of bleeding or pain of each menstrual cycle. Overall-pain was the average pain intensity among days in pain and peak-pain was the maximal single-day pain intensity. At the end of treatment, both the overall-pain and peak-pain decreased in the Four-Agents-Decoction (Si Wu Tang group and increased in the placebo group; however, the differences between the two groups were not statistically significant. The trends persisted to follow-up phase. Statistically significant differences in both peak-pain and overall-pain appeared in the first follow

  2. Chinese herbal medicine for treatment of dislipidemia

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    Haiyun Wu; Jianwei Bei; Jiao Guo

    2009-01-01

    Prevalence of dislipidemia is increasing rapidly in China and there has been a growing interest in Chinese herbal medicine for the treatment of hyperlipidemia both inside and outside China. In this article, lipids regulating effects of 9 herbs or their extracts and 5 herbal formulae which have been published in English-language literature are reviewed. Although evidence from animals and humans consistently supports the therapeutic activities of these Chinese herbal medicines, few multi-center large-scale clinical trials have been conducted to confirm the efficacy and evaluate their safety.

  3. A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors

    Directory of Open Access Journals (Sweden)

    Xian-Ze Meng

    2012-01-01

    Full Text Available Introduction. Posttraumatic stress disorder (PTSD is accompanied by poor general psychological status (GPS. In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD. Methods. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula, Xiao-Tan-Jie-Yu-Fang (XTJYF, to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (n=123 and placebo (n=122 groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R and rates of response in the SCL global severity index (GSI were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints. Results and Discussion. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P = 0.001~0.028. More patients in the XTJYF group reported “much improved” than the placebo group (P = 0.001. The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P = 0.001~0.036, and in sleep quality score (P<0.001. XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.

  4. Effects of two Chinese herbal formulae for the treatment of moderate to severe stable chronic obstructive pulmonary disease: a multicenter, double-blind, randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Genfa Wang

    Full Text Available The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD.A multicenter, double-blind, double-dummy, and randomized controlled trial (RCT was conducted. All groups were treated with additional conventional medicines. There were a 6-month treatment and a 12-month follow-up for 5 times. Primary outcomes included lung function test, exacerbation frequency, score of SGRQ. Second outcomes consisted of 6MWD, BODE index, psychological field score, inflammatory factors and cortisol.A total of 331 patients were randomly divided into two active treatment groups (Bushen Yiqi (BY granule group, n = 109; Bushen Fangchuan (BF tablet group, n = 109 and a placebo group (n = 113. Finally 262 patients completed the study. BY granule & BF tablet increased the values of VC, FEV1 (% and FEV1/FVC (%, compared with placebo. BY granule improved PEF. Both treatments reduced acute exacerbation frequency (P = 0.067, BODE index and psychological field score, while improved 6MWD. In terms of descent rang of SGRQ score, both treatments increased (P = 0.01. Both treatments decreased inflammatory cytokines, such as IL-8, and IL-17(P = 0.0219. BY granule obviously descended IL-17(P0.05 among three groups.BY granule and BF tablet were positively effective for the treatment of COPD, and the former performed better in general.Chinese Clinical Trial Register center ChiCTR-TRC-09000530.

  5. Inhibition of Release of Vasoactive and Inflammatory Mediators in Airway and Vascular Tissues and Macrophages by a Chinese Herbal Medicine Formula for Allergic Rhinitis

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    George Binh Lenon

    2007-01-01

    Full Text Available Herbal therapies are being used increasingly for the treatment of allergic rhinitis. The aim of this study was to investigate the possible pharmacological actions and cellular targets of a Chinese herbal formula (RCM-101, which was previously shown to be effective in reducing seasonal allergic rhinitis symptoms in a randomized, placebo-controlled clinical trial. Rat and guinea pig isolated tissues (trachea and aorta were used to study the effects of RCM-101 on responses to various mediators. Production of leukotriene B4 in porcine neutrophils and of prostaglandin E2 and nitric oxide (NO in Raw 264.7 cells were also measured. In rat and guinea pig tracheal preparations, RCM-101 inhibited contractile responses to compound 48/80 but not those to histamine (guinea pig preparations or serotonin (rat preparations. Contractile responses of guinea pig tracheal preparations to carbachol and leukotriene C4, and relaxant responses to substance P and prostaglandin E2 were not affected by RCM-101. In rat aortic preparations, precontracted with phenylephrine, endothelium-dependent relaxant responses to acetylcholine and endothelium-independent relaxant responses to sodium nitroprusside were not affected by RCM-101. However, RCM-101 inhibited relaxations to l-arginine in endothelium-denuded rat aortic preparations, which had been pre-incubated with lipopolysaccharide. RCM-101 did not affect leukotriene B4 formation in isolated porcine neutrophils, induced by the calcium ionophore A23187; however, it inhibited prostaglandin E2 and NO production in lipopolysaccharide-stimulated murine macrophages (Raw 264.7 cells.The findings indicate that RCM-101 may have multiple inhibitory actions on the release and/or synthesis of inflammatory mediators involved in allergic rhinitis.

  6. Chinese herbal formulaTongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

    Institute of Scientific and Technical Information of China (English)

    Peiman Alesheikh; Arezou Mashouif; Hui-ling Tang; Wei Zhang; Bo Di; Yang-yang Yan; Peng-tao Li; Yan-shu Pan

    2015-01-01

    The Chinese herbal formulaTongluo Jiunao, containing the active componentsPanax notogin-seng andGardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administeredTongluo Jiunao, a positive control (Xuesai Tong, containing Panax notoginseng) or saline intraperitoneally to investigate the pathway involved in the action ofTongluo Jiunao injection. 2,3,5-Triphenyltetrazolium chloride (TTC) staining showed that the cerebral infarct area was signiifcantly smaller in model rats that receivedTongluo Jiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in theTongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment withTongluo Jiunao orXuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were signiifcantly elevated compared with saline, with the greatest expression observed afterTongluo Jiunao treatment. These ifndings suggest thatTongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/tropomyosin-related kinase C pathway.

  7. Comprehensive Qualitative Ingredient Profiling of Chinese Herbal Formula Wu-Zhu-Yu Decoction via a Mass Defect and Fragment Filtering Approach Using High Resolution Mass Spectrometry

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    Huarong Xu

    2016-05-01

    Full Text Available The Wu-Zhu-Yu decoction is a traditional Chinese medicine formula for the treatment of headache. To reveal its material basis, a rapid and reliable liquid chromatography-high resolution mass spectrometry method was established for comprehensive profiling of the chemical ingredients in the Wu-Zhu-Yu decoction. The method was used on a quadrupole time-of-flight mass spectrometer along with an advanced data processing procedure consisting of mass accuracy screening, mass defect filtering and fragment filtering. After eliminating interference with a filtering approach, the MS data profiling was made more distinct and accurate. With the optimized conditions of only 35 min LC separation and single sample injection of each positive or negative ion mode, a total of 168 compounds were characterized, including 23 evodiamine and its analogous alkaloids, 12 limonoids, 17 gingerols, 38 ginsenosides, 15 flavonoids, 16 organic acids, 14 alkaloids, 5 saponins, 3 2,2-dimethylchromenes and 25 other compounds. The fragmentation patterns of representative compounds were illustrated as well. Integrative qualitative analysis of the Wu-Zhu-Yu decoction by high resolution mass spectrometry was accomplished and reported for the first time. The study demonstrated that the established method was a powerful and reliable strategy for comprehensive detection and would be widely applicable for identification of complicated components from herbal prescriptions, and may provide a basis for chemical analysis of other complex mixtures.

  8. Comprehensive Qualitative Ingredient Profiling of Chinese Herbal Formula Wu-Zhu-Yu Decoction via a Mass Defect and Fragment Filtering Approach Using High Resolution Mass Spectrometry.

    Science.gov (United States)

    Xu, Huarong; Niu, Huibin; He, Bosai; Cui, Chang; Li, Qing; Bi, Kaishun

    2016-01-01

    The Wu-Zhu-Yu decoction is a traditional Chinese medicine formula for the treatment of headache. To reveal its material basis, a rapid and reliable liquid chromatography-high resolution mass spectrometry method was established for comprehensive profiling of the chemical ingredients in the Wu-Zhu-Yu decoction. The method was used on a quadrupole time-of-flight mass spectrometer along with an advanced data processing procedure consisting of mass accuracy screening, mass defect filtering and fragment filtering. After eliminating interference with a filtering approach, the MS data profiling was made more distinct and accurate. With the optimized conditions of only 35 min LC separation and single sample injection of each positive or negative ion mode, a total of 168 compounds were characterized, including 23 evodiamine and its analogous alkaloids, 12 limonoids, 17 gingerols, 38 ginsenosides, 15 flavonoids, 16 organic acids, 14 alkaloids, 5 saponins, 3 2,2-dimethylchromenes and 25 other compounds. The fragmentation patterns of representative compounds were illustrated as well. Integrative qualitative analysis of the Wu-Zhu-Yu decoction by high resolution mass spectrometry was accomplished and reported for the first time. The study demonstrated that the established method was a powerful and reliable strategy for comprehensive detection and would be widely applicable for identification of complicated components from herbal prescriptions, and may provide a basis for chemical analysis of other complex mixtures. PMID:27213316

  9. Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial

    Science.gov (United States)

    Cao, Yuxue; Du, Yijie; Zhang, Hongying; Luo, Qingli; Li, Bei; Wu, Jinfeng; Lv, Yubao; Sun, Jing; Jin, Hualiang; Wei, Kai; Zhao, Zhengxiao; Kong, Lingwen; Zhou, Xianmei; Miao, Qing; Wang, Gang; Zhou, Qingwei; Dong, Jingcheng

    2014-01-01

    Objective The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD. Methods A multicenter, double-blind, double-dummy, and randomized controlled trial (RCT) was conducted. All groups were treated with additional conventional medicines. There were a 6-month treatment and a 12-month follow-up for 5 times. Primary outcomes included lung function test, exacerbation frequency, score of SGRQ. Second outcomes consisted of 6MWD, BODE index, psychological field score, inflammatory factors and cortisol. Results A total of 331 patients were randomly divided into two active treatment groups (Bushen Yiqi (BY) granule group, n = 109; Bushen Fangchuan (BF) tablet group, n = 109) and a placebo group (n = 113). Finally 262 patients completed the study. BY granule & BF tablet increased the values of VC, FEV1 (%) and FEV1/FVC (%), compared with placebo. BY granule improved PEF. Both treatments reduced acute exacerbation frequency (P = 0.067), BODE index and psychological field score, while improved 6MWD. In terms of descent rang of SGRQ score, both treatments increased (P = 0.01). Both treatments decreased inflammatory cytokines, such as IL-8, and IL-17(P = 0.0219). BY granule obviously descended IL-17(P0.05) among three groups. Conclusions BY granule and BF tablet were positively effective for the treatment of COPD, and the former performed better in general. Trial Registration Chinese Clinical Trial Register center ChiCTR-TRC-09000530 PMID:25118962

  10. Instruction to Authors of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Chinese Herbal Medicines, an international journal sponsored by the Tianjin Institute of Pharmaceutical Research and Institute of Medicinal Plant Develop-ment. The Journal s purpose is to provide a forum for the studies on Chinese herbal medicines, traditional medicines, and natural products.

  11. Comprehensive Qualitative Ingredient Profiling of Chinese Herbal Formula Wu-Zhu-Yu Decoction via a Mass Defect and Fragment Filtering Approach Using High Resolution Mass Spectrometry

    OpenAIRE

    Huarong Xu; Huibin Niu; Bosai He; Chang Cui; Qing Li; Kaishun Bi

    2016-01-01

    The Wu-Zhu-Yu decoction is a traditional Chinese medicine formula for the treatment of headache. To reveal its material basis, a rapid and reliable liquid chromatography-high resolution mass spectrometry method was established for comprehensive profiling of the chemical ingredients in the Wu-Zhu-Yu decoction. The method was used on a quadrupole time-of-flight mass spectrometer along with an advanced data processing procedure consisting of mass accuracy screening, mass defect filtering and fra...

  12. Formula and Pharmacological Identification of Diarrhea Arresting and Dysentery Treating Dietary Traditional Chinese Herbal Medicine for Livestock%兽用止痢、止泻中草药制剂的配方及药理鉴定

    Institute of Scientific and Technical Information of China (English)

    蔡璐; 蒋秀全; 杨何; 蔡一鸣

    2014-01-01

    [目的]研制出具有止痢,止泻功效的兽用中草药配方制剂。[方法]使用该中草药制剂配方对患畜进行临床疗效试验和药理试验。[结果]疗效试验表明,该配方对家畜腹痛、腹泻及粪便变化有较好疗效,治愈率达92%。药理试验表明,该配方对受试动物的胃肠运动有显著的抑制作用,其药物的止痢,止泻的功效极为显著,且对受试动物是安全的,可靠的。[结论]该配方对治疗仔猪白痢,仔猪黄痢,家畜肠胃炎及消化不良性腹泻有独特的疗效,可用于兽医临床、也可作为饲料添加剂。%This study was aimed to develop the Chinese herbal formula with dysentery arresting and antidiarrheal effect. [Method] The Chinese herbal for-mulation was used to carry out the clinical curative effect test and pharmacological test for il livestock. [Results] Curative effect test showed that the formula had good effect on abdominal pain, diarrhea and fecal changes of livestock, and the cure rate reached up to 92%. Pharmacological experiments showed that the formula had sig-nificant inhibitory effect on the gastrointestinal motility of the tested animals, and the diarrhea arresting and dysentery treating effect of the formula was also extremely significant. In addition, the formula was safe for tested animals, proving to be reli-able. [Conclusion] The formula has distinct curative effect on treating white scour of piglets, yel ow scour of piglets, livestock gastroenteritis and lienteric diarrhea, and it can also be used in veterinary clinic, as wel as be used as feed additive.

  13. Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD

    Directory of Open Access Journals (Sweden)

    Zhao P

    2016-03-01

    Full Text Available Peng Zhao,1,2 Liping Yang,1,2 Jiansheng Li,1,2 Ya Li,1,2 Yange Tian,1,2 Suyun Li2,3 1Key Laboratory of Chinese Internal Medicine, Henan University of Traditional Chinese Medicine, 2Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, 3Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, People’s Republic of China Abstract: Bufei Jianpi formula (BJF has long been used as a therapeutic agent in the treatment of COPD. Systems pharmacology identified 145 active compounds and 175 potential targets of BJF in a previous study. Additionally, BJF was previously shown to effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. However, the system-level mechanism of BJF for the treatment of COPD is still unclear. The aim of this study was to gain insight into its system-level mechanisms by integrating transcriptomics, proteomics, and metabolomics together with systems pharmacology datasets. Using molecular function, pathway, and network analyses, the genes and proteins regulated in COPD rats and BJF-treated rats could be mainly attributed to oxidoreductase activity, antioxidant activity, focal adhesion, tight junction, or adherens junction. Furthermore, a comprehensive analysis of systems pharmacology, transcript, protein, and metabolite datasets is performed. The results showed that a number of genes, proteins, metabolites regulated in BJF-treated rats and potential target proteins of BJF were involved in lipid metabolism, cell junction, oxidative stress, and inflammatory response, which might be the system-level therapeutic mechanism of BJF treatment. Keywords: Bufei Jianpi formula, system-level therapeutic mechanism, transcriptomic, proteomic

  14. A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis.

    Science.gov (United States)

    Han, Xiang-Dong; Zhou, Zhi-Wei; Yang, Wei; Ye, Hang-Cheng; Xu, Ying-Zi; Huang, Yun-Feng; Zhang, Tong; Zhou, Shu-Feng

    2015-01-01

    Ischemic heart disease (IHD) is the leading cause of death worldwide and remains a major life-threatening factor in humans. Apoptosis has been implicated in the pathogenesis of IHD. The Chinese herbal formula Huo Luo Xiao Ling Dan (HLXLD), one of the commonly used Chinese herbal formulas, consists of Salviae miltiorrhizae, Angelica sinensis, Gummi olibanum, and Commiphora myrrha, with a wide spectrum of pharmacological activity. However, the mechanism of action and molecular targets of HLXLD in the treatment of IHD are unclear. This study aimed to computationally predict the molecular interactions between the major active components of HLXLD and key regulators of apoptosis and then examine the effect of HLXLD on coronary artery ligation-induced acute myocardial ischemia in rats. The molecular interactions between the major active components of HLXLD, including ferulic acid, ligustilide, succinic acid, vanillic acid, tanshinone IIA, tanshinone IIB, danshensu, salvianolic acid A, salvianolic acid C, protocatechuic aldehyde, and β-boswellic acid and human protein molecules including B cell lymphoma-extra large (Bcl-xl), B cell lymphoma 2 antagonist/killer 1 (Bak1), B cell lymphoma 2 (Bcl-2), procaspase 3, and caspase 9 with regard to hydrogen bond formation, charge interaction, and π-π stacking using Discovery Studio(®) program 3.1. The 12 HLXLD components were predicted by ADMET (absorption, distribution, metabolism, excretion and toxicity) Predictor to have favorable pharmacokinetic and low hepatotoxicity profiles. The acute myocardial ischemia was established by surgical ligation of the left anterior descending coronary artery. The rats were divided into a sham operative group, a model group, a positive control group treated with 0.2 mg/kg isosorbide mononitrate, and groups treated with 2.7, 5.4, or 10.8 g/kg HLXLD. The results showed that administration of HLXLD increased mean arterial pressure, left ventricular systolic pressure, heart rate, and maximal rate

  15. Clinical Observation of Bronchial Asthma at Chronic Persistent Stage Treated with Compound Chinese Herbal Formulas%中药复方治疗支气管哮喘慢性持续期患者临床观察

    Institute of Scientific and Technical Information of China (English)

    隋艾凤; 徐艳玲; 邓虎

    2015-01-01

    目的:观察中药复方治疗支气管哮喘慢性持续期(虚实夹杂证)患者的安全性与有效性。方法将180例患者随机分为治疗组与对照组,治疗组120例,对照组60例。两组均按需吸入β2受体激动剂和吸入型糖皮质激素( ICS)。治疗组与对照组均在此基础上分别予中药复方制剂口服及安慰剂口服治疗。分别观察、检测两组安全性指标、症状、体征、肺功能[1秒钟用力呼气容积( FEV1)、呼气峰流速( PEF)]情况。结果两组安全性指标检测,均未发现明显异常。两组总有效率比较,差异有统计学意义( P<0.05)。主要症状、体征总积分、FEV1、PEF比较比较,治疗组均优于对照组(P<0.05)。结论中药复方治疗支气管哮喘慢性持续期(虚实夹杂证),能够提高临床疗效,在改善患者症状、体征、肺功能等诸多方面效果优于单纯应用西药,充分体现中西医结合治疗本病的优势,值得临床推广应用。%Objective To observe the safety and effectiveness of bronchial asthma at chronic persis-tent stage( mixture syndrome of deficiency and excess)treated with compound Chinese herbal formulas. Meth-ods One hundred and eighty cases were randomized into a treatment group and an observation group,120 cases in the treatment group and 60 cases in the control group. Inhaled beta 2 agonist and inhaled corticoste-roids were given timely in the two groups. Additionally,the compound Chinese herbal formula and placebo were prescribed for oral administration in the two groups respectively. The safety index,symptoms,physical signs and lung function( FEV1 and PEF)were observed and detected in the two groups. Results The abnor-mality was not discovered in the safety detection of the two groups. The total effective rates were different sig-nificantly between the two groups(P<0. 05). The total scores of main symptoms and physical signs,FEV1 and PEF in the

  16. Immunomodulatory Effect of Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang in Lipopolysaccharide-Induced Acute Lung Injury Mice

    Directory of Open Access Journals (Sweden)

    Chia-Hung Lin

    2013-01-01

    Full Text Available Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT, consisting of 13 medicinal plants, was used to treat patients with lung diseases. This study investigated the immunoregulatory effect of SFYCT on intratracheal lipopolysaccharides- (LPS- challenged acute lung injury (ALI mice. SFYCT attenuated pulmonary edema, macrophages, and neutrophils infiltration in the airways. SFYCT decreased inflammatory cytokines, including tumor necrosis factor-α (TNFα, interleukin-1β, and interleukin-6 and inhibited nitric oxide (NO production but increased anti-inflammatory cytokines, interleukin-4, and interleukin-10, in the bronchoalveolar lavage fluid of LPS-challenged mice. TNFα and monocyte chemotactic protein-1 mRNA expression in the lung of LPS-challenged mice as well as LPS-stimulated lung epithelial cell and macrophage were decreased by SFYCT treatment. SFYCT treatment also decreased the inducible nitric oxide synthase expression and phosphorylation of nuclear factor-κB (NF-κB in the lung of mice and macrophage with LPS stimulation. SFYCT treatment dose dependently decreased the LPS-induced NO and reactive oxygen species generation in LPS-stimulated macrophage. In conclusion, SFYCT attenuated lung inflammation during LPS-induced ALI through decreasing inflammatory cytokines production while increasing anti-inflammatory cytokines production. The immunoregulatory effect of SFYCT is related to inhibiting NF-κB phosphorylation.

  17. Effective Components of Chinese Herbal Compound Decoction and Maillard Reaction

    Institute of Scientific and Technical Information of China (English)

    曹治云; 陈旭征; 张恩达; 杜建

    2009-01-01

    This paper intends to explore the color changes considered to be Maillard reaction during the process of Chinese herbal medicine.The Maillard reaction products(MRPs) are often in substantial proportions of Chinese herbal compound decoctions but their effects are often neglected.By considering the effects of MRPs in studies of effective components on Chinese herbal compounds,a new perspective is established in future researches of Chinese herbal compound decoctions.

  18. A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis

    Directory of Open Access Journals (Sweden)

    Han XD

    2015-02-01

    Full Text Available Xiang-Dong Han,1 Zhi-Wei Zhou,2–4 Wei Yang,1 Hang-Cheng Ye,1 Ying-Zi Xu,1 Yun-Feng Huang,1 Tong Zhang,1 Shu-Feng Zhou2 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, 4Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guizhou Medical University, Guiyang, People’s Republic of China Abstract: Ischemic heart disease (IHD is the leading cause of death worldwide and remains a major life-threatening factor in humans. Apoptosis has been implicated in the pathogenesis of IHD. The Chinese herbal formula Huo Luo Xiao Ling Dan (HLXLD, one of the commonly used Chinese herbal formulas, consists of Salviae miltiorrhizae, Angelica sinensis, Gummi olibanum, and Commiphora myrrha, with a wide spectrum of pharmacological activity. However, the mechanism of action and molecular targets of HLXLD in the treatment of IHD are unclear. This study aimed to computationally predict the molecular interactions between the major active components of HLXLD and key regulators of apoptosis and then examine the effect of HLXLD on coronary artery ligation-induced acute myocardial ischemia in rats. The molecular interactions between the major active components of HLXLD, including ferulic acid, ligustilide, succinic acid, vanillic acid, tanshinone IIA, tanshinone IIB, danshensu, salvianolic acid A, salvianolic acid C, protocatechuic aldehyde, and β-boswellic acid and human protein molecules including B cell lymphoma-extra large (Bcl-xl, B cell lymphoma 2 antagonist/killer 1 (Bak1, B cell lymphoma 2 (Bcl-2, procaspase 3, and caspase 9 with regard to hydrogen bond formation, charge interaction, and π-π stacking using Discovery Studio® program 3.1. The 12 HLXLD components were predicted by

  19. Tianjin Press of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>Chinese Traditional and Herbal Drugs The journal started publication monthly since January 1970, is an academic and technical journal sponsored by Chinese Pharmaceutical Association and Tianjin Institute of Pharmaceutical Research. The journal which has a long history over 40 years offers the columns of research papers, brief reports, reviews, dissertation, and special treatises to report the recent achievements of the basic study, production, quality

  20. Latest Progress on Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    Tianjin Press of Chinese Herbal Medicines

    2010-01-01

    @@ Chinese Herbal Medicines (CHM) has been recently included in the Wanfang Database-Digital Periodical Group, China Academic Journals Integrated Online Database, Index of Copernicus (IC) in Poland, Chemical Abstracts Service (CAS) in USA, and Ulrich's Periodicals Directory domestically and abroad.

  1. Systematic chemical profiling of a multicomponent Chinese herbal formula Huo Luo Xiao Ling Dan by ultra high performance liquid chromatography coupled with electrospray ionization quadrupoletime-of-flight mass spectrometry.

    Science.gov (United States)

    Wang, Fenrong; Ai, Yu; Wu, Yun; Ma, Wen; Bian, Qiaoxia; Lee, David Y-W; Dai, Ronghua

    2015-03-01

    Huo Luo Xiao Ling Dan, a Chinese herbal formula consisting of 11 different herbs, has been used in folk medicine for the treatment of arthritis and other chronic inflammatory diseases. However, the chemical compositions of Huo Luo Xiao Ling Dan are not completely characterized. In the present study, an ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry method in positive and negative ion modes was employed to identify biochemical constitutes in Huo Luo Xiao Ling Dan. As a result, a total of 76 compounds including alkaloids, monoterpene glycosides, iridoids, phenolic acids, and tanshinones, coumarins, lactones, flavones, and their glycosides, triterpenes, and triterpene saponins were characterized by comparing the retention time and mass spectrometry data with reference standards within 5 ppm error or by reference to the reference literature. These results would provide the basis for a further in vivo study of Huo Luo Xiao Ling Dan and information for potential new drug candidates for treating arthritis and other chronic inflammatory diseases.

  2. Fumanjian, a Classic Chinese Herbal Formula, Can Ameliorate the Impairment of Spatial Learning and Memory through Apoptotic Signaling Pathway in the Hippocampus of Rats with Aβ1–40-Induced Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Hai-yan Hu

    2014-01-01

    Full Text Available Alzheimer’s disease (AD is the most common form of dementia and lacks disease-altering treatments. Fumanjian (FMJ, a famous classic Chinese herbal prescription for dementia, was first recorded in the Complete Works of Jingyue during the Ming Dynasty. This study aimed to investigate whether FMJ could prevent cognitive deficit and take neuroprotective effects in Aβ1–40-induced rat model through apoptotic signaling pathway. AD model was established by bilateral injection of Aβ1–40 into hippocampus in rat. All rats were tested for their capabilities of spatial navigation and memorization by Morris water maze. Apoptosis was tested using TUNEL staining in hippocampus neuronal cells; RT-PCR tested expression of Bcl-2 and Bax mRNA; western blotting tested protein level of cleaved caspase-3. After 14 days of treatment, FMJ significantly improved the escape latency and enhanced platform-cross number compared with the Aβ1–40-injected group (P<0.05 or P<0.01. FMJ also significantly decreased number of TUNEL-positive neuronal apoptosis and the expressions of Bax and cleaved Caspase-3 and increased the expression of Bcl-2 (P<0.01 compared with AD model group. In conclusion, FMJ exerts a protective effect against Aβ1–40-induced learning and memory deficits and neuronal apoptosis, suggesting that FMJ could be used as a potential therapeutic formula for AD.

  3. An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula, Qing-Luo-Yin

    Directory of Open Access Journals (Sweden)

    Bo Zhang

    2013-01-01

    Full Text Available The scientific understanding of traditional Chinese medicine (TCM has been hindered by the lack of methods that can explore the complex nature and combinatorial rules of herbal formulae. On the assumption that herbal ingredients mainly target a molecular network to adjust the imbalance of human body, here we present a-self-developed TCM network pharmacology platform for discovering herbal formulae in a systematic manner. This platform integrates a set of network-based methods that we established previously to catch the network regulation mechanism and to identify active ingredients as well as synergistic combinations for a given herbal formula. We then provided a case study on an antirheumatoid arthritis (RA formula, Qing-Luo-Yin (QLY, to demonstrate the usability of the platform. We revealed the target network of QLY against RA-related key processes including angiogenesis, inflammatory response, and immune response, based on which we not only predicted active and synergistic ingredients from QLY but also interpreted the combinatorial rule of this formula. These findings are either verified by the literature evidence or have the potential to guide further experiments. Therefore, such a network pharmacology strategy and platform is expected to make the systematical study of herbal formulae achievable and to make the TCM drug discovery predictable.

  4. Analysis of active patents to investigate the frequency and patterns of Chinese herbal extract combinations claiming to treat heart disease

    Directory of Open Access Journals (Sweden)

    Jiangxue Cheng

    2016-04-01

    Conclusion: Most of the high-frequency Chinese herbs in the patents investigated belong to the high-frequency herbal families, and herb pairs were commonly selected to coincide with the commonly-used herbal family pairs. Low-frequency Chinese herbs were also used, but generally belonged to the high-frequency herbal families, and were therefore similar to the high-frequency herbs in terms of traditional categories of taste and channel entered. The results reflect the use of traditional principles of formula composition, and suggest that these principles may indeed be an effective guide for further research and development of Chinese herbal extract combinations to prevent and treat heart diseases.

  5. Latest Progress in Tianjin Press of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>Four journals including Chinese Traditional and Herbal Drugs (CTHD), Chinese Herbal Medicines (CHM), Drugs & Clinic (DC), and Drug Evaluation Research (DER) are edited and published by Tianjin Press of Chinese Herbal Medicines. CTHD was first published in 1970 and has been playing a great role for Chinese materia medica (CMM), especially in its present modernization. CTHD has successively won several honors in recent years, such as the 2nd State

  6. Er-Xian Decoction, a traditional Chinese herbal formula, intervening early in hypothalamic-pituitary axis of male rats with delayed puberty

    OpenAIRE

    Zheng Zhu; LiHong Li; Xin Jin; JianWei Fang; DongFang Zhang

    2014-01-01

    Background: Er-Xian Decoction (EXD) is one of the traditional Chinese medicine (TCM) with unique effect on osteoporosis, menopausal syndrome and delayed puberty in China for many years. Objective: We aim to evaluate the potential activity of starting hypothalamic-pituitary-testicular (HPT) axis of male rats with delayed puberty. Materials and Methods : Delayed puberty model of male Sprague-Dawley (SD) rats were established with soy isoflavones (90 mg·kg -1 ) and were treated by EXD extract at...

  7. Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD

    Science.gov (United States)

    Zhao, Peng; Yang, Liping; Li, Jiansheng; Li, Ya; Tian, Yange; Li, Suyun

    2016-01-01

    Bufei Jianpi formula (BJF) has long been used as a therapeutic agent in the treatment of COPD. Systems pharmacology identified 145 active compounds and 175 potential targets of BJF in a previous study. Additionally, BJF was previously shown to effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. However, the system-level mechanism of BJF for the treatment of COPD is still unclear. The aim of this study was to gain insight into its system-level mechanisms by integrating transcriptomics, proteomics, and metabolomics together with systems pharmacology datasets. Using molecular function, pathway, and network analyses, the genes and proteins regulated in COPD rats and BJF-treated rats could be mainly attributed to oxidoreductase activity, antioxidant activity, focal adhesion, tight junction, or adherens junction. Furthermore, a comprehensive analysis of systems pharmacology, transcript, protein, and metabolite datasets is performed. The results showed that a number of genes, proteins, metabolites regulated in BJF-treated rats and potential target proteins of BJF were involved in lipid metabolism, cell junction, oxidative stress, and inflammatory response, which might be the system-level therapeutic mechanism of BJF treatment. PMID:27042044

  8. Fumanjian, a Classic Chinese Herbal Formula, Can Ameliorate the Impairment of Spatial Learning and Memory through Apoptotic Signaling Pathway in the Hippocampus of Rats with Aβ 1–40 -Induced Alzheimer's Disease

    OpenAIRE

    Hai-yan Hu; Zhi-hui Cui; Hui-qin Li; Yi-ru Wang; Xiang Chen; Ji-huang Li; Dong-mei Xv; Guo-qing Zheng

    2014-01-01

    Alzheimer's disease (AD) is the most common form of dementia and lacks disease-altering treatments. Fumanjian (FMJ), a famous classic Chinese herbal prescription for dementia, was first recorded in the Complete Works of Jingyue during the Ming Dynasty. This study aimed to investigate whether FMJ could prevent cognitive deficit and take neuroprotective effects in Aβ 1–40-induced rat model through apoptotic signaling pathway. AD model was established by bilateral injection of Aβ 1–40 into hippo...

  9. Er-Xian Decoction, a traditional Chinese herbal formula, intervening early in hypothalamic-pituitary axis of male rats with delayed puberty

    Directory of Open Access Journals (Sweden)

    Zheng Zhu

    2014-01-01

    Full Text Available Background: Er-Xian Decoction (EXD is one of the traditional Chinese medicine (TCM with unique effect on osteoporosis, menopausal syndrome and delayed puberty in China for many years. Objective: We aim to evaluate the potential activity of starting hypothalamic-pituitary-testicular (HPT axis of male rats with delayed puberty. Materials and Methods : Delayed puberty model of male Sprague-Dawley (SD rats were established with soy isoflavones (90 mg·kg -1 and were treated by EXD extract at doses of 5, 10 g·kg -1 or Testosterone undecanoate (TU for 8 weeks. Body weight, body length, testis weight, T, E 2 and luteinizing hormone (LH in serum, gonadotropin releasing hormone (GnRH in hypothalamus, follicle stimulating hormone (FSH and LH in pituitary gland were determined by ELISA. Immunohistochemistry was used to detect LH in pituitary gland . Results: Soy isoflavones could significantly decrease body weight, body length, testicular organ coefficient T in serum, GnRH in hypothalamus, FSH and LH in pituitary gland. Both of EXD and TU could improve the condition. E 2 and LH in serum of all groups were non-significance of difference (P > 0.05. The immunohistochemical results were well consistent with LH in pituitary gland. Conclusion: The results of the present research indicate that EXD extract is effective to start the HPT axis in puberty and can significantly improve sexual developmental inhibition caused by soy isoflavones.

  10. Karyotype and DNA-Methylation Responses in Myelodysplastic Syndromes following Treatment with Traditional Chinese Formula Containing Arsenic

    OpenAIRE

    Sun Shuzhen; Ma Rou; Hu Xiaomei; Yang Xiao-hong; Xu Yong-gang; Wang Hongzhi; Yang Xiu-Peng

    2012-01-01

    We have previously shown that arsenic-containing Chinese herbal formula, Qing-Huang powder capsule (containing tetraarsenic tetrasulfide, As4S4), is effective in the treatment of myelodysplastic syndrome (MDS); yet the underlined mechanisms remain unclear. In this study, using standard cytogenetic analysis (G-banded) and global DNA methylation method (ChIP-on-chip assays), we aimed to determine the effect of arsenic-containing Chinese herbal formula on karyotype status and the genomic methyla...

  11. Chinese herbal medicine research in eczema treatment

    Directory of Open Access Journals (Sweden)

    Leung Ping

    2011-04-01

    Full Text Available Abstract Eczema is a chronic relapsing atopic dermatitis (AD associated with pruritus, sleep disturbance and poor quality of life of the patient. Treatment of eczema includes use of emollient, topical and systemic antimicrobial agents, corticosteroid or immunomodulating agents. Many patients also seek alternative treatments such as dietary avoidance, supplementation or both. This article reviews the basic pathophysiology of eczema and clinical trials involving Chinese medicine in the treatment of eczema. Research reports on Chinese herbal medicine for eczema were retrieved from PubMed and the Cochrane Database for Systematic Reviews for this review. Only a few RCTs demonstrated the efficacy (or lack of efficacy of Chinese medicinal herbs in treating atopic eczema. Further larger scale trials are warranted.

  12. Chinese herbal medicine for severe acute respiratory syndrome

    DEFF Research Database (Denmark)

    Liu, Jianping; Manheimer, Eric; Shi, Yi;

    2004-01-01

    To review randomized controlled trials (RCTs) evaluating the effects of Chinese herbal medicine for treating severe acute respiratory syndrome (SARS) systematically.......To review randomized controlled trials (RCTs) evaluating the effects of Chinese herbal medicine for treating severe acute respiratory syndrome (SARS) systematically....

  13. Studies on Treating Eczema by Chinese Herbal Medicine with Anti-Type Ⅳ Allergic Activity

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To study Chinese herbal prescription for treatment of eczema on the basis of the suppressive effect of Chinese herbal medicine with type Ⅳ allergic reaction. Methods: Various formulae composed of Chinese herbal medicines possessing suppressive effect on murine allergic contact dermatitis were formed following the therapeutic principles of traditional Chinese medicine in treating eczema, and their effect on ear swelling, ear flake weight, dermal inflammatory infiltration cell count and plasma level of calcitonin gene related peptide ( CGRP) were examined in mice with dinitrofluorobenzene induced dermatitis. The prescription, Composite Poria Decoction was formulated and made into granule form, which was used to treat 63 cases of eczema (atopic dermatitis was excluded), and compared with 59 cases treated with antihistaminic that was aimed at the type I allergic reaction. Results: Experimental study showed that all the 4 Chinese prescriptions had the effect of anti-type Ⅳ allergic reaction, among them, the formula for cooling blood and removing Heat, Wind and Dampness evil possessed the most potent effect in suppressing murine dermatitis, and it was also able to up-regulate the plasma CGRP concentration. The clinical cure rate of Composite Poria Granule treatment was 47.6%, and that of the control was 22.0%. The difference was significant between the two groups (u=2.9555, P<0.01). Conclusions: Chinese herbal medicine has the effect of anti-type Ⅳ allergic reaction. Composite Poria Granule has good effect in treating eczema.

  14. Hexa-herbal Chinese formula for eczema

    DEFF Research Database (Denmark)

    Chang, J.; Jäger, Anna; Heinrich, M.;

    2014-01-01

    against S. aureus and also Bacillus subtilis, Escherichia coli and Pseudomonus aeruginosa were tested. HHCF demonstrated anti-hyaluronidase activity in a dose-dependence manner. However, no anti-bacterial activity was observed. Metabolic fingerprints for the HHCF and a series of preparation each lacking...

  15. Safety and efficacy assessment of standardized herbal formula PM012

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    Sohn Sung-Hwa

    2012-03-01

    Full Text Available Abstract Background This study was conducted to evaluate the efficacy of the herbal formula PM012 on an Alzheimer's disease model, human presenilin 2 mutant transgenic mice (hPS2m, and also to evaluate the toxicity of PM012 in Sprague-Dawely rats after 4 or 26 weeks treatment with repeated oral administration. Methods Spatial learning and memory capacities of hPS2m transgenic mice were evaluated using the Morris Water Maze. Simultaneously, PM012 was repeatedly administered orally to male and female SD rats (15/sex/group at doses of 0 (vehicle control, 500, 1,000 and 2,000 mg/kg/day for 4 or 26 weeks. To evaluate the recovery potential, 5 animals of each sex were assigned to vehicle control and 2,000 mg/kg/day groups during the 4-week recovery period. Results The results showed that PM012-treated hPS2m transgenic mice showed significantly reduced escape latency when compared with the hPS2m transgenic mice. The repeated oral administration of PM012 over 26 weeks in male and female rats induced an increase and increasing trend in thymus weight in the female treatment groups (main and recovery groups, but the change was judged to be toxicologically insignificant. In addition, the oral administration of the herbal medicine PM012 did not cause adverse effects as assessed by clinical signs, mortality, body weight, food and water consumption, ophthalmology, urinalysis, hematology, serum biochemistry, blood clotting time, organ weights and histopathology. The No Observed Adverse Effects Levels of PM012 was determined to be 2,000 mg/kg/day for both sexes, and the target organ was not identified. Conclusion These results suggest that PM012 has potential for use in the treatment of the Alzheimer's disease without serious adverse effects.

  16. Safety concerns of herbal products and traditional Chinese herbal medicines: Dehydropyrrolizidine alkaloids and aristolochic acid

    Science.gov (United States)

    In many countries, including the United States, herbal supplements, tisanes and vegetable products, including traditional Chinese medicines, are largely unregulated and their content is not registered, monitored or verified. Consequently, potent plant toxins including dehydropyrrolizidine alkaloids ...

  17. Do Herbal Formulas Influence the International Normalized Ratio of Patients Taking Warfarin? A Retrospective Study

    Directory of Open Access Journals (Sweden)

    Hsu-Yuan Lu

    2015-01-01

    Full Text Available Warfarin is a common anticoagulant agent for cardiovascular diseases, and it is known to interact with several foods and drugs. Several studies report an interaction between warfarin and herbal medicines; however, the influence of herbal medicines on the international normalized ratio (INR is still controversial. We investigated the influence of herbal formulas on INR of patients taking warfarin. We searched electronic medical records of inpatients for INR results. Then, we compared the changes in INR and any adverse events between the group taking herbal formulas and warfarin (herbal group and another group taking warfarin only (nonherbal group. Eighty-six patients were included; 45 patients were assigned to the herbal group and 41 patients to the nonherbal group. The herbal group had taken the same dose of warfarin for a longer period. The nonherbal group had a slightly higher mean INR value than the herbal group. The ratio of INR less than 2 and greater than 3, the ratio of INR that increased or decreased by one or more compared to the initial INR, and the ratio of adverse events were not significantly different between the two groups. It is suggested that use of herbal formulas may not influence INR value.

  18. Moxibustion with Chinese herbal has good effect on allergic rhinitis

    OpenAIRE

    Min, Cunyun; Peng, Congjian; Wei, Guojian; Huang, Xuhui; Fu, Tingting; Du, Yu; Wang, Changjun

    2015-01-01

    Allergic rhinitis (AR) is a chronic inflammatory disease of rhino-ocular mucosa, affecting up to 40% of population worldwide. Chinese herbal medicines and Acupuncture, adopted thousands of years in China, has good effect on allergic rhinitis. This study evaluates the effects of Moxibustion with Chinese herbal in treating patients with allergic rhinitis over a 1-year follow-up. A randomized controlled trial was conducted in a sample of 355 participants recruited from Guangdong general hospital...

  19. Evaluation of herbal formulas by pulse analysis method%以脉波分析法评价中草药方

    Institute of Scientific and Technical Information of China (English)

    王唯工; 徐则林; 鲍建国; 王林玉英

    2003-01-01

    AIM: To distinguish the component difference between two similar herbal formulas by pulse analysis method.Many Chinese herbs were found to have specific effects on the Fourier components of the blood pressure pulse; itmight infer a specific blood redistribution process on the body and reflect the health conditions of specific organsor tissues. The pulse effect of an herbal formula was similar to the linear combination of all its herbal compositions.METHODS: Two different versions of the herbal formula Liu-Wei-Dihuang were fed to the Wistar rats as a singleblind test. The blood pressure pulses on the rat tail artery were recorded and then transformed to the frequencydomain by Fourier analyzer. RESULTS: Formula A, Bai-Wei-Dihuang, with two more herbs Cortex Cinnamomiand Radix Aconiti added to Liu-Wei-Dihuang, increased the harmonic proportion of the 1st harmonic (C1) butdecreased C4, C5. Formula B is composed in the same way but without Rhizoma Batatatis and Poria cocos; itincreased the DC of the pulse spectrum (CO), but decreased C2, C3, C4, C5, C6. CONCLUSION: The componentadjustment of an herbal formula could be distinctly and quantitatively detected by pulse analysis method.

  20. Tonic Herbs and Herbal Mixtures in Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Thomas Efferth

    2016-01-01

    Full Text Available This review results from a PubMed-based data-mining of scientific literature concerning typical tonic herbs and formulas of Chinese herbal medicine and their application principle under the theory of CM. We have focused on two aspects of tonic activity: body tonification against qi气-, blood血-, yin阴- and yang阳-deficiency, respectively, and organ (Zang 脏and Fu腑 tonification against heart-, liver-, spleen/stomach-, lung-, and kidney-deficiency, respectively. Body-tonifying herbs are: Astragalus Membranaceus Radix (Huang-qi黄芪 and Panax Ginseng Radix (Ren-shen人参 for qi-tonification; Angelicae Sinensis Radix (Dang-gui当归 and Rehmannia Glutinosa Radix Preparata (Shu-di熟地 for blood-tonification; Ophiopogon Japonicus Radix (Mai-dong麦冬 and Scrophularia Ningpoensis Radix (Xuan-shen玄参 for yin-deficiency; Myristica Fragrans Semen (Rou-dou-kou肉豆蔻 and Psoralea Corylifolia Fructus (Bu-gu-zhi补骨脂 for yang-deficiency. The corresponding CM formulas are: Bu-zhong-yi-qi decoction (补中益气汤 for qi-tonification; Si-wu decoction (四物汤 for blood-tonification; Zeng-ye decoction (增液汤 for yin-tonification; Si-shen pill (四神丸 for yang-tonification. Organ-tonifying herbs are: Glycyrrhizae Uralensis Radix Preparata (Zhi-gan-cao炙甘草 and Rehmannia Glutinosa Radix (Di-huang地黄 for heart-tonification; Lycium Barbarum Fructus (Gou-qi-zi枸杞子 and Angelicae Sinensis Radix (Dang-gui当归 for liver-tonification; Panax Ginseng Radix (Ren-shen人参 and Atractylodis Macrocephala Rhizoma (Bai-zhu白术 for spleen/stomach-tonification; Panax Ginseng Radix (Ren-shen人参 and Astragalus Membranaceus Radix (Huang-qi黄芪 for lung-tonification; Cornus Officinalis Fructus (Shan-zhu-yu山茱萸 and Dioscorea Opposite Rhizoma (Shan-yao山药 for kidney-tonification. The corresponding CM formulas are: Zhi-gan-cao decoction (炙甘草汤 for heart-tonification; Yi-guan decoction (一贯煎 for liver

  1. Herbal hepatoxicity from Chinese skullcap: A case report

    OpenAIRE

    Yang, Leslie; Aronsohn, Andrew; Hart, John; Jensen, Donald

    2012-01-01

    The use of herbal supplements has increased considerably over the last decade. We report a case of an elderly woman who began taking Move Free Advanced for arthritis, which in addition to glucosamine and chondroitin, contained two herbal ingredients, Chinese skullcap and Black Catechu. Our patient presented with significant cholestasis and hepatitis which significantly improved after discontinuation of the supplement. Since neither the patient nor the treating physician recognized this supple...

  2. The use of Chinese herbal drugs in Islamic medicine

    Institute of Scientific and Technical Information of China (English)

    Mojtaba Heyadri; Mohammad Hashem Hashempur; Mohammad Hosein Ayati; Detlev Quintern; Majid Nimrouzi; Seyed Hamdollah Mosavat

    2015-01-01

    This paper investigates some of the ways that Chinese medicine has been transferred to the Western world and to Islamic territories. During the Golden Age of Islam (8th to 13th century CE), the herbal drug trade promoted significant commercial and scientific exchange between China and the Muslim world. Chinese herbal drugs have been described by medieval Muslim medical scholars such as Tabari (870 CE), Rhazes (925 CE), Haly Abbas (982 CE), Avicenna (1037 CE) and Jurjani (1137 CE). The term al-sin (the Arabic word for China) is used 46 times in Avicenna’s Canon of Medicine in reference to herbal drugs imported from China. Cinnamon (dar sini; “Chinese herb”), wild ginger (asaron), rhubarb (rivand-e sini), nutmeg (basbasa), incense tree wood (ood), cubeb (kababe) and sandalwood (sandal) were the most frequently mentioned Chinese herbs in Islamic medical books. There are also multiple similarities between the clinical uses of these herbs in both medical systems. It appears that Chinese herbal drugs were a major component of the exchange of goods and knowledge between China and the Islamic and later to the Western world amid this era.

  3. The use of Chinese herbal drugs in Islamic medicine.

    Science.gov (United States)

    Heyadri, Mojtaba; Hashempur, Mohammad Hashem; Ayati, Mohammad Hosein; Quintern, Detlev; Nimrouzi, Majid; Heyadri, Mojtaba

    2015-11-01

    This paper investigates some of the ways that Chinese medicine has been transferred to the Western world and to Islamic territories. During the Golden Age of Islam (8th to 13th century CE), the herbal drug trade promoted significant commercial and scientific exchange between China and the Muslim world. Chinese herbal drugs have been described by medieval Muslim medical scholars such as Tabari (870 CE), Rhazes (925 CE), Haly Abbas (982 CE), Avicenna (1037 CE) and Jurjani (1137 CE). The term al-sin (the Arabic word for China) is used 46 times in Avicenna's Canon of Medicine in reference to herbal drugs imported from China. Cinnamon (dar sini; "Chinese herb"), wild ginger (asaron), rhubarb (rivand-e sini), nutmeg (basbasa), incense tree wood (ood), cubeb (kababe) and sandalwood (sandal) were the most frequently mentioned Chinese herbs in Islamic medical books. There are also multiple similarities between the clinical uses of these herbs in both medical systems. It appears that Chinese herbal drugs were a major component of the exchange of goods and knowledge between China and the Islamic and later to the Western world amid this era. PMID:26559361

  4. Global Expansion Strategy of Chinese Herbal Tea Beverage

    Directory of Open Access Journals (Sweden)

    Yong Liu

    2015-03-01

    Full Text Available In order to provide insights into the potential future of Chinese herbal tea beverage industry, we analyze serious challenge on how the herbal tea beverage will develop global expansion strategy in china, as well as a series of recommendations as to how the sector might collaborate and respond. This study discusses the key challenges and opportunities factors that Chinese traditional tea industry face, from across the global value chain, representing both producer and consumer countries and including topics ranging from climate change to finance and markets. For these ever-growing problems, factors as diverse as the use of precision farming, biodiversity, production instability and consumer demand for personalization of products were identified. To support the development of Chinese traditional tea industry, increase investment, vigorously promote to transfer Chinese traditional tea into fast, convenient, standardized and normalized tea beverage products for global expansion strategy of Chinese herbal tea beverage, so as to promote the development of Chinese traditional tea industry and make the regional contribution to the realization of Chinese dream.

  5. [Study of changes in Chinese herbal medicine distribution channel].

    Science.gov (United States)

    Lv, Hua; Yang, Guang; Huang, Lu-Qi

    2014-07-01

    Distribution channel of Chinese herbal medicines has been changing. From Han to Ming Dynasty, Chinese herbal medicine were mainly trafficked to urban by dealers or farmers; From the Ming Dynasty to the foundation of new China, distribution channels are primarily intermediated with township "bazaar" and national distribution center with fixed place and regularly trading hours. In the planned economy period, the state-owned herbal medicine company was the sole medium with monopoly nature. From the mid1980s to the end of last century, planned economy and market economy have been co-existing. Stepping into 21st century, producing area highlighted in the distribution channels. Presence or absence and rise or fall of different types of distribution market went throughout the changing process of distribution channels, which became an important clue. Changes were motivated by economical consideration of channel subject, which originated from commodity characteristic and social environment changes. PMID:25272514

  6. Chinese Herbal Products for Female Infertility in Taiwan

    OpenAIRE

    Hung, Yu-Chiang; Kao, Chao-Wei; Lin, Che-Chen; Liao, Yen-Nung; Wu, Bei-Yu; Hung, I-Ling; Hu, Wen-Long

    2016-01-01

    Abstract Female infertility and low birth rate are significant public health issues with profound social, psychological, and economic consequences. Some infertile women resort to conventional, complementary, or alternative therapies to conceive. The aim of this study was to identify the Chinese herbal products (CHPs) most commonly used for female infertility in Taiwan. The usage of traditional Chinese medicine (TCM) and the frequency of CHP prescriptions to infertile women were determined bas...

  7. Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs

    Institute of Scientific and Technical Information of China (English)

    Woo-Jin Choi; Hwa-Seung Yoo; Yeon-Weol Lee; Chang-Gue Son; Jang-Woo Shin; Jin-Young Son; Dong-Seok Seo; Hark-Soo Park; Seung-Hyun Han; Ha-Jung Sung; Jung-Hyo Cho; Chong-Kwan Cho

    2006-01-01

    AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study.METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology,urinalysis, and biochemical analysis.RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopathology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology,haematology, urinalysis, and biochemistry were found with any dose of this drug.CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.

  8. Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula

    Directory of Open Access Journals (Sweden)

    Soo-Jin Jeong

    2014-01-01

    Full Text Available Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese, a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS and 2,2-diphenyl-1-picrylhydrazyl (DPPH radicals. GKT also significantly reduced the malondialdehyde (MDA generation during low-density lipoprotein (LDL oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.

  9. Safety concerns of herbal products and traditional Chinese herbal medicines: dehydropyrrolizidine alkaloids and aristolochic acid.

    Science.gov (United States)

    Stegelmeier, Bryan L; Brown, Ammon W; Welch, Kevin D

    2015-12-01

    In many countries, including the United States, herbal supplements, tisanes and vegetable products, including traditional Chinese medicines, are largely unregulated and their content is not registered, monitored or verified. Consequently, potent plant toxins including dehydropyrrolizidine alkaloids and other potential carcinogens can contaminate these products. As herbal and food supplement producers are left to their own means to determine the safety and purity of their products prior to marketing, disturbingly often good marketing practices currently in place are ignored and content is largely undocumented. Historical examples of poisoning and health issues relating to plant material containing dehydopyrrolizidine alkaloids and aristolochic acids were used as examples to demonstrate the risk and potential toxicity of herbal products, food supplements, or traditional medicines. More work is needed to educate consumers of the potential risk and require the industry to be more responsible to verify the content and insure the safety of their products. PMID:26152912

  10. Karyotype and DNA-Methylation Responses in Myelodysplastic Syndromes following Treatment with Traditional Chinese Formula Containing Arsenic

    Directory of Open Access Journals (Sweden)

    Sun Shuzhen

    2012-01-01

    Full Text Available We have previously shown that arsenic-containing Chinese herbal formula, Qing-Huang powder capsule (containing tetraarsenic tetrasulfide, As4S4, is effective in the treatment of myelodysplastic syndrome (MDS; yet the underlined mechanisms remain unclear. In this study, using standard cytogenetic analysis (G-banded and global DNA methylation method (ChIP-on-chip assays, we aimed to determine the effect of arsenic-containing Chinese herbal formula on karyotype status and the genomic methylation level in primarily diagnosed MDS patients. Correlation of aberrant DNA methylation and chromosome aberrations in MDS was also investigated. We found that the number of genes with aberrant DNA methylation was highest in MDS patients with normal karyotype, followed by trisomy 8 karyotype, and relatively low in patients with cytogenetic abnormalities other than trisomy 8. Treatment with arsenic-containing Chinese herbal formula had no effects on karyotype status, but resulted in a significant genome-wide demethylation. Our research uncovered a DNA demethylating activity of arsenic-containing Chinese herbal formula in the treatment of MDS.

  11. [Research progress of Chinese herbal medicine raw materials in cosmetics].

    Science.gov (United States)

    Xie, Yan-jun; Kong, Wei-jun; Yang, Mei-hua; Yang, Shi-hai

    2015-10-01

    Advocating green, nature, environmental protection, safety and the pursuit of efficacy are the trends of cosmetics in the world. In recent years, more and more Chinese herbal extracts with mild, high safety and small irritation are applied to cosmetics as the natural additives. This has become a new hot spot. The recent application advances of Chinese medicine raw materials in cosmetics are overviewed according to their main functions. This review will provide useful references for the future development and application of Chinese medicinal herbs cosmetics. PMID:27062803

  12. [Research progress of Chinese herbal medicine raw materials in cosmetics].

    Science.gov (United States)

    Xie, Yan-jun; Kong, Wei-jun; Yang, Mei-hua; Yang, Shi-hai

    2015-10-01

    Advocating green, nature, environmental protection, safety and the pursuit of efficacy are the trends of cosmetics in the world. In recent years, more and more Chinese herbal extracts with mild, high safety and small irritation are applied to cosmetics as the natural additives. This has become a new hot spot. The recent application advances of Chinese medicine raw materials in cosmetics are overviewed according to their main functions. This review will provide useful references for the future development and application of Chinese medicinal herbs cosmetics.

  13. Introduction of Chinese Traditional and Herbal Drugs

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The journal published monthly since January 1970 is an academic and technical journal sponsored by Chinese Pharmaceutical Association and Tianjin Institute of Pharmaceutical Research (TIPR). The journal which has a long history of 40-years offers the columns of research papers brief reports, reviews, dissertation, and special treatises to report the recent achievements of our basic study, production quality control, and clinic application on traditional Chinese medicine and Chinese materia medica.

  14. Oral treatment with the herbal formula B307 alleviates cardiac toxicity in doxorubicin-treated mice via suppressing oxidative stress, inflammation, and apoptosis

    Directory of Open Access Journals (Sweden)

    Lien CY

    2015-05-01

    , cardiac expressions of endothelial nitric oxide synthase, superoxide dismutase 2, and B-cell lymphoma 2 were significantly enhanced, but tumor necrosis factor alpha, NFKB1 (p50 and its precursor, p105, neurotrophin-3, Bcl-2-associated X protein, calpain, caspase 12, caspase 9, and caspase 3 were significantly suppressed in DOX-treated mice under oral treatment with the herbal formula B307.Conclusion: Our results revealed that oral treatment with the herbal formula B307 may provide cardioprotection in DOX-treated mice via suppressing oxidative stress, inflammation, and apoptosis in heart tissue. We believe that the herbal formula B307 may be developed as a potential alternative treatment for cancer patients under DOX treatment. Keywords: doxorubicin, cardiac protection, oxidative stress, inflammation, apoptosis, Chinese herbal formula, mouse model

  15. Traditional herbal formula Sini Powder extract produces antidepressant-like effects through stress-related mechanisms in rats.

    Science.gov (United States)

    Wei, Shan-Shan; Yang, He-Jin; Huang, Jia-Wen; Lu, Xue-Ping; Peng, Ling-Fang; Wang, Qing-Guo

    2016-08-01

    Sini Powder (SP), a traditional Chinese herbal formula, has long been used to treat depression in patients, although the underlying mechanisms remain to be elucidated. In the present study, we found that rats treated with SP extract for 7 days showed a significant increase in swimming time and reduction in immobility time in forced swimming test in a dose-dependent manner, without changes in locomotion. These effects could be attributed to SP's modulation of the hypothalamus-pituitary-adrenal axis, because a single pretreatment of SP extract could rescue increased serum corticosterone and plasma adrenocorticotropin levels induced by acute elevated platform stress. A single pretreatment of SP extract could also elevate the mRNA expression of hippocampal glucocorticoid receptors. In conclusion, our results suggest that SP extract may act as an anti-stress medication to produce antidepressant-like effects.

  16. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

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    Fang-Pey Chen

    2011-01-01

    Full Text Available Chinese herbal medicine (CHM has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and an association rule was applied to evaluate the co-prescription of CHM. Results showed that there were 16 134 subjects who visited TCM clinics for insomnia in Taiwan during 2002 and received a total of 29 801 CHM prescriptions. Subjects between 40 and 49 years of age comprised the largest number of those treated (25.3%. In addition, female subjects used CHMs for insomnia more frequently than male subjects (female : male = 1.94 : 1. There was an average of 4.8 items prescribed in the form of either an individual Chinese herb or formula in a single CHM prescription for insomnia. Shou-wu-teng (Polygonum multiflorum was the most commonly prescribed single Chinese herb, while Suan-zao-ren-tang was the most commonly prescribed Chinese herbal formula. According to the association rule, the most commonly prescribed CHM drug combination was Suan-zao-ren-tang plus Long-dan-xie-gan-tang, while the most commonly prescribed triple drug combination was Suan-zao-ren-tang, Albizia julibrissin, and P. multiflorum. Nevertheless, further clinical trials are needed to evaluate the efficacy and safety of these CHMs for treating insomnia.

  17. Acute Renal Failure Induced by Chinese Herbal Medication in Nigeria

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    Effiong Ekong Akpan

    2015-01-01

    Full Text Available Traditional herbal medicine is a global phenomenon especially in the resource poor economy where only the very rich can access orthodox care. These herbal products are associated with complications such as acute renal failure and liver damage with a high incidence of mortalities and morbidities. Acute renal failure from the use of herbal remedies is said to account for about 30–35% of all cases of acute renal failure in Africa. Most of the herbal medications are not usually identified, but some common preparation often used in Nigeria includes “holy water” green water leaves, bark of Mangifera indica (mango, shoot of Anacardium occidentale (cashew, Carica papaya (paw-paw leaves, lime water, Solanum erianthum (Potato tree, and Azadirachta indica (Neem trees. We report a rare case of a young man who developed acute renal failure two days after ingestion of Chinese herb for “body cleansing” and general wellbeing. He had 4 sessions of haemodialysis and recovered kidney function fully after 18 days of admission.

  18. Modernization of Chinese herbal compound and the high performance liquid chromatography tandem mass spectrometry (HPLC-MS)

    Institute of Scientific and Technical Information of China (English)

    LI Wen-lan; SUN Zhi; DU Juan

    2008-01-01

    Chinese herbal compound is playing an important role on curing human diseases. And it has been a trend that Chinese herbal compound is being used all over the world in 21 century. However, our Chinese herbal compound is facing serious challenge for the lack of canonical system of quality criterion for Chinese herbal compound so it has been a urgent problem to set up the quality control standards and reveal therapeutic basis of Chinese herbal compound. In order to give full play to the advantages of Chinese herbal compound, modern scientific and technological is used to research of Chinese herbal compound, especially the high performance liquid chromatography tandem mass spectrometry(HPLC-MS), because it is high sensitive, rapid, and obtain more information. It is very necessary that HPLC-MS is uesed to elucidate the effective components of basic substances of Chinese Herbal Compound, and endow traditional Chinese medicine with modern scientific connotation.

  19. Chemical and Physical Methods to Analyze a Multicomponent Traditional Chinese Herbal Prescription Using LC-MS/MS, Electron Microscope, and Congo Red Staining

    Directory of Open Access Journals (Sweden)

    Chia-Ming Lu

    2013-01-01

    Full Text Available This study develops several chemical and physical methods to evaluate the quality of a traditional Chinese formulation, Jia-Wei-Xiao-Yao-San. Liquid chromatography-tandem mass spectrometry (LC-MS/MS coupled with electrospray ionization was used to measure the herbal biomarkers of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin from this herbal formula. A scanning electron microscope (SEM and light microscopy photographs with Congo red staining were used to identify the cellulose fibers if raw herbal powder had been added to the herbal pharmaceutical product. Moreover, water solubility and crude fiber content examination were used to inspect for potential herbal additives to the herbal pharmaceutical products. The results demonstrate that the contents of the herbal ingredients of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin were around 0.351 ± 0.017, 0.136 ± 0.010, 0.140 ± 0.005, and 2.281 ± 0.406 mg/g, respectively, for this herbal pharmaceutical product. The physical examination data demonstrate that the raw herbal powder had rough, irregular, lumpy, filamentous, and elongated shapes, as well as strong Congo red staining. In addition, water solubility and crude fiber content were not consistent in the herbal pharmaceutical products.

  20. Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-βpeptide (1-42)-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway

    Institute of Scientific and Technical Information of China (English)

    Jiao Li; Yan Tan; Qi Zhang; Xu Wang; Angran Fan; Qian Hua; Feng Wang; Haimin Ding; Chunyan Jin; Jinyan Chen; Yanan Zhao; Xiaojing Li; Wenju Chen; Ping Sun

    2014-01-01

    Tongluojiunao (TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. TLJN has been shown to protect primary cultured hippocampal neurons. How-ever, its mechanism of action remains unclear. In the present study, primary cultured hippocampal neurons treated with Aβ1-42 (10 µmol/L) signiifcantly increased the release of lactate dehydroge-nase, which was markedly reduced by TLJN (2 µL/mL), speciifcally by the component geniposide (26 µmol/L), but not ginsenoside Rg1 (2.5 µmol/L). hTe estrogen receptor inhibitor, ICI182780 (1 µmol/L), did not block TLJN-or geniposide-mediated decrease of lactate dehydrogenase under Aβ1-42-exposed conditions. However, the phosphatidyl inositol 3-kinase or mitogen-activated protein kinase pathway inhibitor, LY294002 (50 µmol/L) or U0126 (10 µmol/L), respectively blo cked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. hTerefore, these results suggest that the non-classical estrogen pathway (i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, speciifcally its component, geniposide, against Aβ1-42-mediated cell death in primary cultured hippocampal neurons.

  1. Diseases,formula and Chinese herbal medicines:a study on spleen-stom-ach dampness-heat pattern based on modern literature%基于现代文献的脾胃湿热证疾病分布及处方用药研究

    Institute of Scientific and Technical Information of China (English)

    刘路路; 李婷婷; 吴秀艳; 王天芳; 薛晓琳; 罗清香; 张晓娜; 任红; 侯帅颖; 张佳元

    2016-01-01

    :脾胃湿热证) as subject term or title /keyword,the databases of China National Knowledge Infrastructure(CNKI),Wan-fang Data Knowledge Service Platform and VIP Information were systematically retrieved,from the begin-ning of the databases to 31 December,2015.The articles related to treatment on SSDHP were collected, and the database was established by using Microsoft Excel 2010,on which data were descriptively statisti-cal analyzed.Results 109 articles were eligible from total 1 681 retrieved ones.The top two diseases with SSDHP were digestive system disorders (86.41%)and dermatoses (5.83%).The common formu-la directed at clearing heat and dampness including Pingwei Powder,Huopu Xialing Decoction,and Sanren Decoction,combined with specific medications for exact symptoms.The common Chinese herbal medications with frequency more than 1 percent were listed as the following:Golden Thread (Huangli-an),Pinellia Tuber(Banxia),Official Magnolia Bark(Houpu),Liquorice Root (Gancao),Dried De-coctionerine Peel (Chenpi),Baical Skullcap Root (Huangqin),Indian Bread (Fuling),Dandelion (Pugongying),Agastache Rugosus (Huoxiang),Atractylodes Rhizome (Cangzhu),Coix Seed (Yiy-iren),Round Cardamon Fruit (Baidoukou),Largehead Atractylodes Rhizome (Baizhu),Orange Fruit (Zhiqiao),Immature Orange Fruit (Zhizi ),Corydalis Rhizoma (Yanhusuo ),White Peony Root (Baishao),Medicinal Evodia Fruit (Wuzhuyu),Dried Ginger (Ganjiang),Bamboo Shavings (Zhu-ru),Virgate Wormwood Herb (Yinchen),Grassleaf Sweetflag Rhizome (Shichangpu),Turmeric Root Tuber (Yujin),Immature Orange Fruit (Zhishi),Chinese Thorowax Root(Chaihu),Common Bletilla Tuber (Baiji),Danshan Root (Danshen),Bitter Apricot Seed (Kuxingren),Villous Amomum Fruit (Sharen),Common Aucklandia Root (Muxiang),Finger Citron (Foshou),Talc (Huashi).Conclu-sion Now,the diseases with SSDHP were most common in digestive system,but also in other systems. And the prescription and Chinese herbal medicines should be applied by holistic conception,combination of disease and

  2. Genotoxic and tumorigenic pyrrolizidine alkaloids in Chinese herbal plants

    Institute of Scientific and Technical Information of China (English)

    P.P. Fu; Q. Xia; M.W. Chou; G. Lin

    2005-01-01

    Pyrrolizidine alkaloids are a class of hepatotoxic and tumorigenic compounds detected in Chinese herbal plants,contaminated foods, and dietary supplements. In this review, the sources, toxicity, genotoxicity, tumorigenicity, and the metabolic pathways,particular the activation pathways leading to hepatotoxicity and tumorigenicity, of pyrrolizidine alkaloids are briefly discussed, with a focus on the most recent important findings concerning the genotoxic mechanism by which riddelliine liver tumors. This mechanism involves the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts and may be general to most carcinogenic pyrrolizidine alkaloids.

  3. Discrimination of Chinese Herbal Medicine by Machine Olfaction

    Directory of Open Access Journals (Sweden)

    Yawen Shao

    2013-02-01

    Full Text Available “Small Sample Size” (SSS problem would occur while using linear discriminant analysis (LDA algorithm with traditional Fisher criterion if the within-class scatter matrix is singular. The combination of maximum scatter difference (MSD criterion and LDA algorithm for solve SSS problem is described. It is employed to detect three kinds of Chinese herbal medicines from different growing areas by machine olfaction. Compared with PCA or PCA + LDA algorithm, the classification result was enhanced. It works out that only a few samples of Anhui Atractylodes are classified incorrectly, however, the classification rate reaches 97.8%.

  4. Anti-fibro-hepatocarcinogenic Chinese herbal medicines: A mechanistic overview.

    Science.gov (United States)

    Boye, Alex; Yang, Yan; Asenso, James; Wei, Wei

    2016-01-01

    Chinese herbal medicine (CHM) is an integral component of complementary/alternative medicine and it is increasingly becoming the preferred therapeutic modality for the treatment of liver fibrosis and hepatocellular carcinoma (HCC) worldwide. Accordingly, the World Health Organization (WHO) has attested to the popularity and efficacy of indigenous herbal therapies including CHM as a first line of treatment for some diseases including liver disorders. However, the WHO and drug discovery experts have always recommended that use of indigenous herbal remedies must go hand-in-hand with the requisite mechanistic elucidation so as to constitute a system of verification of efficacy within the ethnobotanical context of use. Although many CHM experts have advanced knowledge on CHM, nonetheless, more enlightenment is needed, particularly mechanisms of action of CHMs on fibro-hepato-carcinogenesis. We, herein, provide in-depth mechanisms of the action of CHMs which have demonstrated anti-fibro-hepatocarcinogenic effects, in pre-clinical and clinical studies as published in PubMed and other major scientific databases. Specifically, the review brings out the important signaling pathways, and their downstream targets which are modulated at multi-level by various anti-fibro-hepatocarcinogenic CHMs. PMID:27366355

  5. Anti-fibro-hepatocarcinogenic Chinese herbal medicines: A mechanistic overview

    Science.gov (United States)

    Boye, Alex; Yang, Yan; Asenso, James; Wei, Wei

    2016-01-01

    Chinese herbal medicine (CHM) is an integral component of complementary/alternative medicine and it is increasingly becoming the preferred therapeutic modality for the treatment of liver fibrosis and hepatocellular carcinoma (HCC) worldwide. Accordingly, the World Health Organization (WHO) has attested to the popularity and efficacy of indigenous herbal therapies including CHM as a first line of treatment for some diseases including liver disorders. However, the WHO and drug discovery experts have always recommended that use of indigenous herbal remedies must go hand-in-hand with the requisite mechanistic elucidation so as to constitute a system of verification of efficacy within the ethnobotanical context of use. Although many CHM experts have advanced knowledge on CHM, nonetheless, more enlightenment is needed, particularly mechanisms of action of CHMs on fibro-hepato-carcinogenesis. We, herein, provide in-depth mechanisms of the action of CHMs which have demonstrated anti-fibro-hepatocarcinogenic effects, in pre-clinical and clinical studies as published in PubMed and other major scientific databases. Specifically, the review brings out the important signaling pathways, and their downstream targets which are modulated at multi-level by various anti-fibro-hepatocarcinogenic CHMs. PMID:27366355

  6. New Progress in Modern Research on Chinese Herbal Medicines Published in Chinese Traditional and Herbal Drugs in 2010: Annual Highlights and Comments

    Institute of Scientific and Technical Information of China (English)

    HE Chun-nian; LIU Yan-ze; XIAO Pei-gen

    2011-01-01

    As a series of and continuous publication,the papers published on Chinese Traditional and Herbal Drugs in 2010 were selectively and briefly highlighted to reflect the new progress on modern research of Chinese herbal medicines.Within 617 articles,chemical constituents (127),pharmaceutics and technology (149),pharmacological studies and clinical observation,and medicinal materials are still major categories.Some comments have also been personally provided.

  7. Chinese Herbal Products for Female Infertility in Taiwan: A Population-Based Cohort Study.

    Science.gov (United States)

    Hung, Yu-Chiang; Kao, Chao-Wei; Lin, Che-Chen; Liao, Yen-Nung; Wu, Bei-Yu; Hung, I-Ling; Hu, Wen-Long

    2016-03-01

    Female infertility and low birth rate are significant public health issues with profound social, psychological, and economic consequences. Some infertile women resort to conventional, complementary, or alternative therapies to conceive. The aim of this study was to identify the Chinese herbal products (CHPs) most commonly used for female infertility in Taiwan. The usage of traditional Chinese medicine (TCM) and the frequency of CHP prescriptions to infertile women were determined based on a nationwide 1-million randomly sampled cohort of National Health Insurance Research Database beneficiaries. Descriptive statistics and multiple logistic regression analysis were employed to estimate the adjusted odds ratio (aOR) for TCM usage and potential risk factors. In total, 8766 women with newly diagnosed infertility were included in this study. Of those, 8430 (96.17%) had sought TCM treatment in addition to visiting the gynecologist. We noted that female infertility patients with risk factors (e.g., endometriosis, uterine fibroids, or irregular menstrual cycle) were more likely to use TCM than those without TCM medication (aOR = 1.83, 1.87, and 1.79, respectively). The most commonly used formula and single CHP were Dang-Gui-Sha-Yao-San (17.25%) and Semen Cuscutae (27.40%), respectively. CHP formula combinations (e.g., Dang-Gui-Sha-Yao-San plus Wen-Jing-Tang 3.10%) or single Chinese herbal combinations (e.g., Semen Cuscutae plus Leonurus japonicus 6.31%) were also commonly used to treat female infertility. Further well-conducted, double-blind, randomized, placebo-controlled studies will be needed to evaluate the efficacy and safety of these CHP combinations for female infertility. PMID:26986137

  8. Effects and Mechanisms of Chinese Herbal Medicine in Ameliorating Myocardial Ischemia-Reperfusion Injury

    Directory of Open Access Journals (Sweden)

    Qing Liu

    2013-01-01

    Full Text Available Myocardial ischemia-reperfusion (MIR injury is a major contributor to the morbidity and mortality associated with coronary artery disease, which accounts for approximately 450,000 deaths a year in the United States alone. Chinese herbal medicine, especially combined herbal formulations, has been widely used in traditional Chinese medicine for the treatment of myocardial infarction for hundreds of years. While the efficacy of Chinese herbal medicine is well documented, the underlying molecular mechanisms remain elusive. In this review, we highlight recent studies which are focused on elucidating the cellular and molecular mechanisms using extracted compounds, single herbs, or herbal formulations in experimental settings. These studies represent recent efforts to bridge the gap between the enigma of ancient Chinese herbal medicine and the concepts of modern cell and molecular biology in the treatment of myocardial infarction.

  9. Anti-foot-and-mouth disease virus effects of Chinese herbal kombucha in vivo.

    Science.gov (United States)

    Fu, Naifang; Wu, Juncai; Lv, Lv; He, Jijun; Jiang, Shengjun

    2015-01-01

    The foot and mouth disease virus (FMDV) is sensitive to acids and can be inactivated by exposure to low pH conditions. Spraying animals at risk of infection with suspensions of acid-forming microorganisms has been identified as a potential strategy for preventing FMD. Kombucha is one of the most strongly acid-forming symbiotic probiotics and could thus be an effective agent with which to implement this strategy. Moreover, certain Chinese herbal extracts are known to have broad-spectrum antiviral effects. Chinese herbal kombucha can be prepared by fermenting Chinese herbal extracts with a kombucha culture. Previous studies demonstrated that Chinese herbal kombucha prepared in this way efficiently inhibits FMDV replication in vitro. To assess the inhibitory effects of Chinese herbal kombucha against FMDV in vitro, swine challenged by intramuscular injection with 1000 SID50 of swine FMDV serotype O strain O/China/99 after treatment with Chinese herbal kombucha were partially protected against infection, as demonstrated by a lack of clinical symptoms and qRT-PCR analysis. In a large scale field trial, spraying cattle in an FMD outbreak zone with kombucha protected against infection. Chinese herbal kombucha may be a useful probiotic agent for managing FMD outbreaks. PMID:26691487

  10. Anti-foot-and-mouth disease virus effects of Chinese herbal kombucha in vivo

    Directory of Open Access Journals (Sweden)

    Naifang Fu

    2015-01-01

    Full Text Available AbstractThe foot and mouth disease virus (FMDV is sensitive to acids and can be inactivated by exposure to low pH conditions. Spraying animals at risk of infection with suspensions of acid-forming microorganisms has been identified as a potential strategy for preventing FMD. Kombucha is one of the most strongly acid-forming symbiotic probiotics and could thus be an effective agent with which to implement this strategy. Moreover, certain Chinese herbal extracts are known to have broad-spectrum antiviral effects. Chinese herbal kombucha can be prepared by fermenting Chinese herbal extracts with a kombucha culture. Previous studies demonstrated that Chinese herbal kombucha prepared in this way efficiently inhibits FMDV replication in vitro. To assess the inhibitory effects of Chinese herbal kombucha against FMDV in vitro, swine challenged by intramuscular injection with 1000 SID50 of swine FMDV serotype O strain O/China/99 after treatment with Chinese herbal kombucha were partially protected against infection, as demonstrated by a lack of clinical symptoms and qRT-PCR analysis. In a large scale field trial, spraying cattle in an FMD outbreak zone with kombucha protected against infection. Chinese herbal kombucha may be a useful probiotic agent for managing FMD outbreaks.

  11. The effect of herbal formula PROVE 1 and Stevia levels in diets on diet utilization of growing pigs

    OpenAIRE

    Kooprasert, S.; Siriwathananukul, Y.; Malithod, S.

    2007-01-01

    The objective of this experiment was to study the effect of 0.2% antibiotic (ascomix-s®, one kilogram of which contains lincomycin hydrochloride 44 g and sulfamethazine 110 g) or 0.25% herbal formulaPROVE 1, combined with five levels of Stevia supplementation in the diets on digestibility of pigs. Two factors; 1) type of drug (0.2% antibiotic and 0.25% herbal formula PROVE 1) and 2) five Stevia levels (0,0.2, 0.4, 0.6 and 0.8%) were investigated and 10 dietary treatments were used in this stu...

  12. Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The ...

  13. Anticancer effects of Chinese herbal medicine, science or myth?

    Institute of Scientific and Technical Information of China (English)

    RUAN Wen-jing; LAI Mao-de; ZHOU Jian-guang

    2006-01-01

    Currently there is considerable interest among oncologists to find anticancer drugs in Chinese herbal medicine (CHM).In the past, clinical data showed that some herbs possessed anticancer properties, but western scientists have doubted the scientific validity of CHM due to the lack of scientific evidence from their perspective. Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of CHM. Experiments showed that CHM played its anticancer role by inducing apoptosis and differentiation, enhancing the immune system, inhibiting angiogenesis, reversing multidrug resistance (MDR), etc. Clinical trials demonstrated that CHM could improve survival, increase tumor response, improve quality of life, or reduce chemotherapy toxicity, although much remained to be determined regarding the objective effects of CHM in human in the context of clinical trials. Interestingly, both laboratory experiments and clinical trials have demonstrated that when combined with chemotherapy, CHM could raise the efficacy level and lower toxic reactions. These facts raised the feasibility of the combination of herbal medicines and chemotherapy, although much remained to be investigated in this area.

  14. Evaluation of standard liver volume formulae for Chinese adults

    Institute of Scientific and Technical Information of China (English)

    Zheng-Rong Shi; Lu-Nan Yan; Bo Li; Tian-Fu Wen

    2009-01-01

    AIM:To evaluate different standard liver volume (SLV) formula and verify the applicability of the formulae for Chinese adults.METHODS:Data from 70 cases of living donor liver transplantation (LDLT) performed at our transplantation centers between January 2008 and April 2009 were analyzed.SLV was estimated using our recently reported formula [the Chengdu formula:SLV (mL) = 11.5×body weight (kg) + 334] and other reported formulae used for Chinese adults.Actual intraoperative liver volumes were obtained from a review of the patients' medical records.RESULTS:The actual right liver volume was not signifi-cantly different from the estimated right liver volume determined by the Chengdu formula,but was significantly smaller than estimates using the Heinemann,Urata,Vauthey,and Lee formulae (P<0.01),and significantly larger than estimates using the Fan formula (P<0.05).CONCLUSION:The Chengdu formula was demonstrated to be reliable by its application in LDLT.

  15. Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders

    OpenAIRE

    Teschke, Rolf; Wolff, Albrecht; Frenzel, Christian; Eickhoff, Axel; Schulze, Johannes

    2015-01-01

    Herbal traditional Chinese medicine (TCM) is used to treat several ailments, but its efficiency is poorly documented and hence debated, as opposed to modern medicine commonly providing effective therapies. The aim of this review article is to present a practical reference guide on the role of herbal TCM in managing gastrointestinal disorders, supported by systematic reviews and evidence based trials. A literature search using herbal TCM combined with terms for gastrointestinal disorders in Pu...

  16. Prevention and Treatment of Osteoporosis with Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiao-ling; FENG Yu-xiong; PENG Yong

    2012-01-01

    In this paper,laboratory reports,medication rules,formulating principles,and research methods are summarized and analyzed,including single herb,compound herbs,and the problems in the prevention and treatment of osteoporosis(OP)within the past decade.With widely recognized efficacy,satisfying achievements have been achieved in preventing and treating OP with Chinese herbal medicines(CHM).However,due to the complex constituents,the pharmacological activities and mechanism of CHM are not clear yet,and there is no unified standard on the diagnosis and syndrome differentiation of OP and the efficacy evaluation of CHM in the treatment.Accordingly,the research in the future should focus on the pharmacology and standardization of CHM in treating OP.

  17. Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease

    Directory of Open Access Journals (Sweden)

    Wang SE

    2015-02-01

    Full Text Available Sheue-Er Wang,1 Ching-Lung Lin,1 Chih-Hsiang Hsu,1 Shuenn-Jyi Sheu,2 Chiang-Ting Chien,1 Chung-Hsin Wu1 1Department of Life Science, National Taiwan Normal University, 2Brion Research Institute of Taiwan, Taipei, Taiwan Abstract: Huntington’s disease (HD is a neurodegenerative disease characterized by motor dysfunction and early death. Despite years of research, the mechanisms responsible for chronic neurodegeneration of HD remain elusive. Chinese traditional medicines might provide new insights or new therapy for HD. The Chinese herbal formula B401 is a well-known Taiwan–US patent formula and a health supplement for promoting blood circulation and enhancing brain function. This study aimed to elucidate the neuroprotective effects of the Chinese herbal formula B401 on the syndrome of HD. Then, we compared the life span and body weight of R6/2 HD mice with and without oral B401 treatment. The ameliorative effects of B401 on the symptom of HD mice were investigated through behavior tests. Expressions of proteins for neuroprotection, angiogenesis, and inflammation in the brain tissue of R6/2 HD mice were compared by using immunostaining and Western blotting techniques. Our study in vitro showed that viabilities of glutamate-treated SH-SY5Y cells were significantly increased under B401 treatment. Our results in vivo showed that duration of survival was increased, body weight loss was reduced, and motor ability was improved in R6/2 HD mice under oral B401 treatment. Subcutaneous microcirculation was enhanced in 3-month R6/2 HD mice under intraperitoneal B401 injections as observed by using moorFLPI laser Doppler imager. Atrophy of cerebrum, midbrain, and cerebellum in 3-month R6/2 HD mice under oral B401 treatment was alleviated as observed by utilizing magnetic resonance imaging. Evidence from immunostaining and Western blotting analysis showed that expressions of mutant huntingtin and tumor necrosis factor-alpha were reduced, while expressions

  18. Effect of Chinese Herbal Medicine on Immunohistochemistry of Harder's Glands of Chickens

    Institute of Scientific and Technical Information of China (English)

    SHEN Ping; GAO Guisheng; SHI Qiumei; LI Min

    2009-01-01

    To investigate the mechanism of action of Chinese herbal medicine, the immunocells of Harder's glands were observed.The healthy Hy-Line Brown chickens of 12-day-old were divided into three groups randomly. The chickens in group 1 and 2 drank the water with 0.5% and 1% Chinese herbal medicine immunopromoter every day. The chickens in group 3 as control drank pure water. The Harder's glands of the chickens from 0.5% group, 1% group and control group at 24, 36 and 48 d after drinking medicine respectively were made into histological section. And then the histological sections were observed histologically. The results showed that Chinese herbal medicine could increase the quantity of the immunocells in glandular organs conspicuously. Immunopotentiator of Chinese herbal medicine could promote the amount and growth of secreted immunoglobuline and elevate the immune level of the organism, and the effect of 1% group was higher than that of 0.5% group.

  19. Effect of Guibi-Tang, a Traditional Herbal Formula, on Retinal Neovascularization in a Mouse Model of Proliferative Retinopathy

    Directory of Open Access Journals (Sweden)

    Yun Mi Lee

    2015-12-01

    Full Text Available Ocular pathologic angiogenesis is an important causative risk factor of blindness in retinopathy of prematurity, proliferative diabetic retinopathy, and neovascular macular degeneration. Guibi-tang (GBT is a frequently used oriental herbal formula in East Asian countries, and is also called Qui-pi-tang in Chinese and Kihi-To in Japanese. In the present study, we investigated the preventive effect of GBT on retinal pathogenic neovascularization in a mouse model of oxygen-induced retinopathy (OIR. C57BL/6 mice were exposed to 75% hyperoxia for five days on postnatal day 7 (P7. The mice were then exposed to room air from P12 to P17 to induce ischemic proliferative retinopathy. GBT (50 or 100 mg/kg/day was intraperitoneally administered daily for five days (from P12 to P16. On P17, Retinal neovascularization was measured on P17, and the expression levels of 55 angiogenesis-related factors were analyzed using protein arrays. GBT significantly decreased retinal pathogenic angiogenesis in OIR mice, and protein arrays revealed that GBT decreased PAI-1 protein expression levels. Quantitative real-time PCR revealed that GBT reduced vascular endothelial growth factor (VEGF, fibroblast growth factor 2 (FGF2, and plasminogen activator inhibitor 1 (PAI-1 mRNA levels in OIR mice. GBT promotes potent inhibitory activity for retinal neovascularization by decreasing VEGF, FGF2, and PAI-1 levels.

  20. Chinese medicinal formula Fufang Xueshuantong capsule could inhibit the activity of angiotensin converting enzyme

    Science.gov (United States)

    Sheng, Shujing; Wang, Yonggang; Long, Chaofeng; Su, Weiwei; Rong, Xia

    2014-01-01

    Fufang Xueshuantong (FXST) capsule, a Chinese medicinal formula composed of four herbals – Panax notoginseng, Radix Astragali, Radix Salvia Miltiorrhizae and Radix Scrophulariaceae, has been used to treat cardiovascular diseases for many years, but the pharmacological mechanisms underlying its effects has not been clarified. This study investigates if a connection between FXST and angiotensin converting enzyme (ACE) might be an explanation for its pharmacological effects. ACE inhibition assay was performed on FXST capsule, 50% ethanol extracts from the four herbals and three selected saponins most abundant in P. notoginseng (Ginsenoside Rg1, Ginsenoside Rb1 and Notoginsenoside R1) using a biochemical test. Reversed-phase high-performance liquid chromatography of liberated hippuric acid from the ACE assay was conducted to determine the inhibitory effect. As a result, FXST and extracts from P. notoginseng showed a significant and dose-dependent inhibition on ACE activity with the IC50 values of 115 μg/ml and 179 μg/ml, respectively. But extracts from the other three herbals and the three selected saponins had no significant effect on ACE inhibition. Compared to other reported plant extracts, FXST could be considered as an effective ACE inhibitor. The inhibition of ACE activity supports the traditional use of FXST on blood circulation and the inhibitory property of FXST is mainly caused by P. notoginseng. PMID:26019516

  1. Methemoglobinemia development after ingestion of a chinese herbal medicine: A case report

    Directory of Open Access Journals (Sweden)

    Se Eun Hyun

    2010-03-01

    Full Text Available An 8-year-old girl visited the emergency room with perioral cyanosis and dyspnea, which had developed 20 hrs prior to the hospital visit. She had taken a Chinese herbal medication for 3 days prior to the onset of the symptoms. A co-oximeter examination revealed a methemoglobin level of 23.7%. An intravenous infusion of methylene blue was administered. Chemical analysis of the herbal medication revealed an ammonia (NH3 level of 239.41 mg/L. More studies are needed on the correlation between methemoglobinemia and the components of Chinese herbal medicines.

  2. Synergistic effects of Chinese herbal medicine: a comprehensive review of methodology and current research

    Directory of Open Access Journals (Sweden)

    Xian Zhou

    2016-07-01

    Full Text Available Traditional Chinese medicine is an important part of primary health care in Asian countries that has utilised complex herbal formulations (consisting 2 or more medicinal herbs for treating diseases over thousands of years. There seems to be a general assumption that the synergistic therapeutic effects of Chinese herbal medicine derive from the complex interactions between the multiple bioactive components within the herbs and/or herbal formulations. However, evidence to support these synergistic effects remains weak and controversial due to several reasons, including the very complex nature of Chinese herbal medicine, misconceptions about synergy, methodological challenges to study design. In this review, we clarify the definition of synergy, identify common errors in synergy research and describe current methodological approaches to test for synergistic interaction. We discuss the strengthen and weakness of these models in the context of Chinese herbal medicine and summarise the current status of synergy research in CHM. Despite the availability of some scientific data to support the synergistic effects of multi-herbal and/or herb-drug combinations, the level of evidence remains low and the clinical relevancy of most of these findings is undetermined. There remain significant challenges in the development of suitable methods for synergistic studies of complex herbal combinations.

  3. The safety of Homnawakod herbal formula containing Aristolochia tagala Cham. in Wistar rats

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    Tripatara Pinpat

    2012-10-01

    Full Text Available Abstract Background A dried root of Aristolochia tagala Cham. (ATC is often used in Thai traditional medicine as an antipyretic, anti-inflammatory agent, muscle relaxant, appetite-enhancing agent, and analeptic. Homnawakod, an important herbal recipe, originally contains ATC in its formula, however, some Aristolochia species have been reported to cause nephrotoxicity due to aristolochic acid (AA and its derivatives, resulting in ATC removal from all formulae. Therefore, this study investigates the chemical profiles of ATC, the original (HNK+ATC and the present Homnawakod Ayurved Siriraj Herbal Formulary™ (HNK, and investigates whether they could cause nephrotoxicity or aggravate LPS-induced organ injuries in vivo. Methods HPLC and LC/MS were used for chemical profile study. Male Wistar rats were randomly divided into groups in which the rats were intragastrically administered distilled water (2 groups, ATC (10 or 30 mg/kg, HNK+ATC (540 or 1,620 mg/kg, or HNK (1,590 mg/kg for 21 days. A positive control group was administered with single dose 100 mg/kg standard AA-I intragastrically at day 1. Serum creatinine and urea were measured at baseline and at 7, 14 and 21 days of the treatment. On day 22, a model of lipopolysaccharide (LPS-induced endotoxemia was used. One-way and two-way analyses of variance were performed and a P value of less than 0.05 was considered to be significant. Results The similarity of the HPLC chromatograms of HNK+ATC and HNK could suggest that the qualities of both formulae are nearly the same in terms of chemical profile. The amount of AA-I found in ATC is 0.24%w/w. All experimental groups exhibited similar levels of serum urea at baseline and 7 and 14 days of the treatment. At 21 days, rats received AA exhibited a significant increase in serum urea, whereas the others did not exhibit such toxicity. On day 22, there were no significant changes in LPS-induced renal and liver dysfunction, or LPS-induced mean arterial

  4. Combination Effects of Herbs in a Multi-herbal Formula: Expression of Juzen-taiho-to's Immuno-modulatory Activity on the Intestinal Immune System

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    Hiroaki Kiyohara

    2004-01-01

    Full Text Available Herbal formulas of traditional Japanese (Kampo, Chinese and Korean medicines usually comprise multiple herbs in a single formula. These medicines are expected to show their clinical effects by chemical, pharmacological and pharmaceutical combination effects of multi-herbs. However, little effort has been made so far to scientifically clarify the nature of such combination effects. Interestingly, for example, though a Kampo medicine Juzen-taiho-to (Shi-Quan-Da-Bu-Tang in Chinese stimulates the immune functions of Peyer's patch cells, none of its single component herbs shows such activity. We thus examined the combination effect of herbs in the Juzen-taiho-to formula for the expression of its immuno-stimulating activity. Juzen-taiho-to, a composite formula of 10 herbs, has been generally considered to comprise two kinds of basic formula, each of which consists of four different herbs in addition to two others. The combinations of herbs based on these two basic formulas were evaluated for their stimulating activities on cytokine production from murine Peyer's patch cells both in vitro and ex vivo. Combined decoction of six among 10 herbs in Juzen-taiho-to is crucial for the expression of its stimulating activity on Peyer's patch cells. 3D-HPLC analysis of the ingredients in the fractions from the combined decoctions indicated that, in addition to quantitative changes of ingredients, alterations occur in their chemical composition by decoction of different herbs. The stimulating activity of Juzen-taiho-to on Peyer's patch cells results from the combination effect of its six essential component herbs. This combination effect is based on physicochemical interactions among the ingredients of the component herbs.

  5. Screening of Chinese Herbal Medicines Resistant to Chicken Escherichia coli and Infectious Laryngotracheitis Virus

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    [Objective] This study aimed to screen Chinese herbal medicines resistant to Chicken Escherichia coli and infectious laryngotracheitis virus. [Methed] Conven- tional punch method, test tube method and plate dilution method were adopted for in vitro susceptibility test of chicken E, coil strains O5 and O8 using 13 kinds of Chi- nese herbal medicines including Sanguisorba officinalis, Coptis chinensis, Anemar- rhena asphodeloides, Strobilanthes cusia, Agastache rugosa, etc.; chicken embryo inoculation experiment was adopted to screen Chinese herbal medicines resistant to chicken infectious laryngotracheitis virus. [Result] Sanguisorba officinalis, Fructus mume, Rheum officinale, Coptis chinensis, Herba Taraxaci, Anemarrhena asphode- Ioides, Scutellaria baicalensis and Rhizoma Fagopyri Cymosi had ideal antibacterial effect against chicken E. coil strain O5; Sanguisorba officinalis, Fructus mume, Rheum officinale, Coptis chinensis, Herba taraxaci and Rhizoma Fagopyri Cymosi had ideal antibacterial effect against chicken E. coil strain 08; other Chinese herbal medicines showed relatively poor or no antibacterial effect. Results of chicken embryo inoculation experiment showed that nine kinds of Chinese herbal medicines showed relatively strong anti-lLTV effect, including Forsythia suspensa, Radix Isatidis, Fofium isatidis, Flos Ionicerae, Radix codonopsis, Radix astragali, Atractylodes, Radix gly- cyrrhizae, and Pericarpium granati. [Conclusion] The study laid the foundation for fur- ther development of Chinese herbal compound preparations to treat chicken cofibacil- Iosis, infectious laryngotracheitis and other bacterial, viral diseases.

  6. Prescription Pattern of Chinese Herbal Products for Breast Cancer in Taiwan: A Population-Based Study

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    Jung-Nien Lai

    2012-01-01

    Full Text Available Background. Chinese herbal products (CHPs given as a therapy for symptom relief have gained widespread popularity among women with breast cancer. The aim of this study was to analyze the utilization of CHP among women with breast cancer in Taiwan. Methods. The usage, frequency of services, and CHP prescribed for breast cancer among women with breast cancer were evaluated, recruited from a randomly sampled cohort of 1,000,000 beneficiaries from the National Health Insurance Research Database. The logistic regression method was employed to estimate the odds ratios (ORs for utilization of CHP. Results. 81.5 percent (N=2,236 of women with breast cancer utilized traditional Chinese medicine (TCM and 18% of them sought TCM with the intent of treating their breast cancer. Jia-wei-xiao-yao-san (Augmented Rambling Powder was the most frequently prescribed formula for treating breast cancer. Among the top 10 most frequently prescribed CHP for treating breast cancer, seven contained dang qui (Angelica sinensis-radix and six contained ren shen (Panax ginseng-radix, which are reported to have potential beneficial synergistic effects on breast cancer cells. Conclusion. CHP containing dang qui (Angelica sinensis-radix or ren shen (Panax ginseng-radix are the most frequently prescribed for breast cancer and their effects should be taken into account by healthcare providers.

  7. [Research on distribution of patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular based on cluster analysis].

    Science.gov (United States)

    YANG, Xu-Jie; XIAO, Shi-Ying

    2015-09-01

    To discuss the distribution of patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular, the patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular were cluster analyzed by means of simple statistics and cluster analysis. Clustering variables were composed of patent applications, patent maintained number, related papers' quantity, etc. Chinese herbal compound patents' holders were divided into four categories according to their different scientific research and patent strength. It is the magic weapon for Chinese herbal compound patents' holders that have scientific research patents' transforming and make coordination of patent protection and scientific innovation.

  8. Opportunities to Fast-Track Chinese Herbal Therapies into Clinical Practice Through Research Networks

    Institute of Scientific and Technical Information of China (English)

    Stephen M. Sagar

    2008-01-01

    @@ Chinese herbal therapies provide new opportunities to treat cancer and reduce adverse events at multiple chemical,molecular, and physiological levels. Chinese medicine incorporates the notion of 'biosemiosis.' This emphasizes biology considered from the perspectives of signs conveyed and interpreted in a variety of ways,through systems at the macroscopic and microscopic levels, including the communication of singns and meaning between molecules.

  9. Quality and safety of Chinese herbal medicines guided by a systems biology perspective

    NARCIS (Netherlands)

    Wang, J.; Heijden, R. van der; Spruit, S.; Hankermeier, T.; Chan, K.; Greef, J. van der; Xu, G.; Wang, M.

    2009-01-01

    Chinese herbal medicines, often referred as Chinese materia medica (CMM), are comprised of a complex multicomponent nature. The activities are aimed at the system level via interactions with a multitude of targets in the human body. This review aims at the toxicity aspects of CMM and its preparation

  10. Antacid effects of Chinese herbal prescriptions assessed by a modified artificial stomach model

    Institute of Scientific and Technical Information of China (English)

    Tsung-Hsiu; Wu; I-Chin; Chen; Lih-Chi; Chen

    2010-01-01

    AIM:To assess the antacid effects of the tonic Chinese herbal prescriptions,Si-Jun-Zi-Tang(SJZT) and Shen-Ling-Bai-Zhu-San(SLBZS).METHODS:Decoctions of the tonic Chinese herbal prescriptions,SJZT and SLBZS,were prepared according to Chinese original documents.The pH of the prescription decoctions and their neutralizing effects on artif icial gastric acids were determined and compared with water and the active controls,sodium bicarbonate and colloidal aluminum phosphate.A modified model of Vatier's artificia...

  11. Traditional Herbal Formula Oyaksungi-San Inhibits Adipogenesis in 3T3-L1 Adipocytes

    Directory of Open Access Journals (Sweden)

    Sae-Rom Yoo

    2015-01-01

    Full Text Available Background. Oyaksungi-san (OYSGS is a herbal formula that has been used for treating cardiovascular diseases in traditional Asian medicine. Here, we investigated the antiadipogenic effect of OYSGS extract in 3T3-L1 adipose cells. Methods. 3T3-L1 preadipocytes were differentiated into adipocytes with or without OYSGS. After differentiation, we measured Oil Red O staining, glycerol-3-phosphate dehydrogenase (GPDH activity, leptin production, mRNA, and protein levels of adipogenesis-related factors. Results. OYSGS extract dramatically inhibited intracellular lipid accumulation in the differentiated adipocytes. It also significantly suppressed the (GPDH activity, triglyceride (TG content, and leptin production by reducing the expression of adipogenesis-related genes including lipoprotein lipase, fatty acid binding protein 4, CCAAT/enhancer-binding protein-alpha (C/EBP-α, and peroxisome proliferator-activated receptor gamma (PPAR-γ. Furthermore, OYSGS clearly enhanced phosphorylation of AMP-activated protein kinase (AMPK as well as its substrate acetyl CoA (ACC carboxylase. Conclusions. Our results demonstrate that OYSGS negatively controls TG accumulation in 3T3-L1 adipocytes. We suggest antiadipogenic activity of OYSGS and its potential benefit in preventing obesity.

  12. Positive Drug Screen for Benzodiazepine Due to a Chinese Herbal Product

    OpenAIRE

    Eachus, Patricia L.

    1996-01-01

    A female athlete tested positive for benzodiazepine on a random drug screen. She denied taking any illicit or prescription drugs. The positive screen was found to be caused by undeclared addiction of diazepam to a Chinese herbal product, “Miracle Herb.” Some foreign vitamins, health care products, or herbal tea may contain banned or dangerous additives unknown to the consumer. These additives may include ingredients such as benzodiazepine, mefenamic acid, or corticosteroids. Possible physical...

  13. Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases.

    Science.gov (United States)

    Teschke, Rolf; Zhang, Li; Long, Hongzhu; Schwarzenboeck, Alexander; Schmidt-Taenzer, Wolfgang; Genthner, Alexander; Wolff, Albrecht; Frenzel, Christian; Schulze, Johannes; Eickhoff, Axel

    2015-01-01

    Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed database and searched for the items Traditional Chinese Medicine, TCM, Traditional Asian Medicine, and Traditional Oriental Medicine, also combined with the terms herbal hepatotoxicity or herb induced liver injury. The search focused primarily on English-language case reports, case series, and clinical reviews. We identified reported hepatotoxicity cases in 77 relevant publications with 57 different herbs and herbal mixtures of TCM, which were further analyzed for causality by the Council for International Organizations of Medical Sciences (CIOMS) scale, positive reexposure test results, or both. Causality was established for 28/57 different herbs or herbal mixtures, Bai Xian Pi, Bo He, Ci Wu Jia, Chuan Lian Zi, Da Huang, Gan Cao, Ge Gen, Ho Shou Wu, Huang Qin, Hwang Geun Cho, Ji Gu Cao, Ji Xue Cao, Jin Bu Huan, Jue Ming Zi, Jiguja, Kudzu, Ling Yang Qing Fei Keli, Lu Cha, Rhen Shen, Ma Huang, Shou Wu Pian, Shan Chi, Shen Min, Syo Saiko To, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, and Zhen Chu Cao. In conclusion, this compilation of liver injury cases establishes causality for 28/57 different TCM herbs and herbal mixtures, aiding diagnosis for physicians who care for patients with liver disease possibly related to herbal TCM. PMID:25536637

  14. Scope of claim coverage in patents of fufang Chinese herbal drugs: Substitution of ingredients

    Directory of Open Access Journals (Sweden)

    Tian Jiaher

    2011-08-01

    Full Text Available Abstract Herbal ingredients in a Chinese fufang prescription are often replaced by one or several other herbal combinations. As there have been very few Chinese herbal patent infringement cases, it is still unclear how the Doctrine of Equivalents should be applied to determine the scope of 'equivalents' in Chinese fufang prescriptions. Case law principles from cases in other technical areas such as chemical patents and biological drug patents can be borrowed to ascertain a precise scope of a fufang patent. This article summarizes and discusses several chemical and biopharmaceutical patent cases. In cases where a certain herbal ingredient is substituted by another herb or a combination of herbs, accused infringers are likely to relate herbal drug patents to chemical drug patents with strict interpretation whereas patent owners may take advantage of the liberal application of Doctrine of Equivalence in biopharmaceutical patents by analogizing the complex nature of herbal drugs with biological drugs. Therefore, consideration should be given to the purpose of an ingredient in a patent, the qualities when combined with the other ingredients and the intended function. The scope of equivalents also depends on the stage of the prior art. Moreover, it is desirable to disclose any potential substitutes when drafting the application. Claims should be drafted in such a way that all foreseeable modifications are encompassed for the protection of the patent owner's intellectual property.

  15. Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity on Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    Weihua Chu

    2013-01-01

    Full Text Available Traditional Chinese herbal medicines (TCHMs were tested for their ability of antiquorum sensing. Water extracts of Rhubarb, Fructus gardeniae, and Andrographis paniculata show antiquorumsensing activity when using Chromobacterium violaceum CV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1. Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria. The results indicate a potential modulation of bacterial cell-cell communication, P. aeruginosa biofilm, and virulence factors by traditional Chinese herbal medicine. This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.

  16. Roles of Chinese herbal medicines in ischemic heart diseases (IHD) by regulating oxidative stress.

    Science.gov (United States)

    Wang, Dawei; Wang, Jin; Liu, Yuntao; Zhao, Zhen; Liu, Qing

    2016-10-01

    Ischemic heart disease (IHD) basing on atherosclerosis (AS) is known as a top killer for decades. Oxidative stress, representing excessive oxidation and insufficient elimination, has been proved to be a critical molecular mechanism of IHD and accompanying myocardium dysfunction. Therefore, anti-oxidation therapy may be efficient. Chinese herbal medicine, including extractive compounds, decoctions, patent drugs, and injections, has shown its enormous potential in prevention and treatment of IHD as an effective antioxidant in experimental studies. The aim of this review is to highlight recent studies of Chinese herbal medicine in regulating oxidative stress in IHD. These studies represent recent progress of IHD treatment and indicate the possible pathways and target spots of Chinese herbal medicine. PMID:27390948

  17. Integrated Development of Chinese Herbal Medicine Planting and Tourist Commodities: A Case Study of Green Handmade Soap Development in Shandong Province

    Institute of Scientific and Technical Information of China (English)

    Xiu; LI; Mengxuan; CHEN; Xiaoli; SONG

    2015-01-01

    Combining current situations of Chinese herbal medicine planting industry in Shandong,in line with existing problems of Chinese herbal medicine planting industry,this paper analyzed development prospect of tourist commodity industry in Shandong Province,and came up with actual selection and recommendations for integrated development of Chinese herbal medicine planting and tourist commodities.

  18. The effect of herbal formula PROVE 1 and Stevia levels in diets on diet utilization of growing pigs

    Directory of Open Access Journals (Sweden)

    Kooprasert, S.

    2007-05-01

    Full Text Available The objective of this experiment was to study the effect of 0.2% antibiotic (ascomix-s®, one kilogram of which contains lincomycin hydrochloride 44 g and sulfamethazine 110 g or 0.25% herbal formulaPROVE 1, combined with five levels of Stevia supplementation in the diets on digestibility of pigs. Two factors; 1 type of drug (0.2% antibiotic and 0.25% herbal formula PROVE 1 and 2 five Stevia levels (0,0.2, 0.4, 0.6 and 0.8% were investigated and 10 dietary treatments were used in this study. Ten related growing crossbred (Large White x Landrace barrow pigs (30±1.5 kg body weight were raised in individualmetabolism cages for three collecting periods (30, 40 and 50 kg body weight, each pig was fed one experimental diet throughout the collecting period.The results showed that pigs fed diet with either 0.2% antibiotic or 0.25% herbal formula PROVE 1 had similar digestibility of diet, crude protein (CP, fiber, ash and nitrogen free extract (NFE (89.01 vs 87.83,94.96 vs 94.23, 60.73 vs 59.03, 61.22 vs 60.44 and 93.28 vs 92.03%, respectively. Negligible differences were observed between 0 and 0.4% Stevia supplementation in diet, but levels showed better digestibility than the other levels of Stevia supplementation, and the diet with 0.4% Stevia supplementation had the highestdigestibility of diet, CP, fiber, ash and NFE (91.04, 96.43, 69.48, 70.47 and 94.07%, respectively. The diet with antibiotic combined with 0.4% Stevia had digestibility of diet, CP, fat and fiber better than the otherlevels of Stevia supplementation, especially digestibility of ash, which was significantly higher than that of diet with 0.2% Stevia, but not significantly different from the other levels of Stevia supplementation. A partof herbal formula PROVE1 combined with 0% Stevia had the highest digestibility of ash (72.90%, significantly higher than the other levels of Stevia supplementation, except the diet with herbal formula PROVE 1combined with 0.4% Stevia supplementation

  19. Clinical Study on Treatment of Hyperuricaemia by Retention Enema of Chinese Herbal Medicine Combined with Allopurinol

    Institute of Scientific and Technical Information of China (English)

    陈茜; 马丽; 阿克拜尔·乌普

    2009-01-01

    Objective:To study the effect of retention enema of Chinese herbal medicine combined with allopurinol in treating hyperuricaemia(HUE).Methods:Seventy-eight patients with HUE were assigned to two groups,the 40 patients in the treated group were treated with retention enema of Chinese herbal medicine combined with oral intake of allopurinol,and the 38 patients in the control group were treated with allopurinol alone. The therapeutic course for all was 6 weeks.The clinical efficacy,changes of symptoms,blood...

  20. [Analysis of toxicity of traditional Chinese herbal medicine and its connotation].

    Science.gov (United States)

    Liang, Qi; Xie, Ming

    2009-02-01

    Based on traditional Chinese medicine theory and clinical experience, traditional Chinese herbal drug toxicity has its own special connotation. From the perspective of history and logic, the different comprehension of toxicity between Western medicine and traditional Chinese medicine was discussed after retracing the meaning of "drug toxicity" in traditional Chinese medicine. The authors suggest that it's not feasible to study the Chinese medicine coping mechanically and applying indiscriminately the concept and the research idea about modern drug toxicity since there is different understanding of "drug toxicity" between traditional Chinese medicine and Western medicine. Many control elements are involved in the use of traditional Chinese herbal drugs, and Chinese drug components and actions are complex as compared with Western drugs. More and more drugs with toxicity will be found due to the relativity of drug toxicity. Currently, the study of Chinese drug toxicity should pay more attention to the relation between the toxicity and Chinese drug nature, compatibility and the corresponding disease or syndrome pattern after making definition of Chinese drug toxicity and its connotation. PMID:19216849

  1. Application of microcalorimetry of Escherichia coli growth and discriminant analysis to the quality assessment of a Chinese herbal injection (Yinzhihuang

    Directory of Open Access Journals (Sweden)

    Yongshen Ren

    2012-06-01

    Full Text Available This paper describes a novel approach to the quality control of a Chinese herbal injection based on microcalorimetric determination of its effect on the biothermal active fingerprint (BTAF of Escherichia coli (E. coli growth. Yinzhihuang Injection (YZHI was selected for this proof of concept study. Reference samples of YZHI were collected and compared with test (stressed samples prepared under different stress conditions. The BTAF of E. coli growth was found to be affected by YZHI and the changes were analyzed on the basis of eleven biothermokinetic parameters. Similarity and multivariate statistical analysis were used to investigate the differences between reference and test samples and discriminant analysis was used to delineate the altered samples. Reference samples were found to have coincident BTAFs with similarity index >0.99. Stressed samples showed differences in the BTAF which increased in line with decreased quality. Discriminant formulae were developed based on a sensitivity parameter which could identify all altered samples. In conclusion, BTAF can be used to assess the quality of YZHI both qualitatively and quantitatively and has the potential to provide a sensitive method for quality control of Chinese herbal injections.

  2. A meta-analysis of Chinese herbal medicines for vascular dementia

    Institute of Scientific and Technical Information of China (English)

    Xiude Qin; Yu Liu; Yanqing Wu; Shuo Wang; Dandan Wang; Jinqiang Zhu; Qiaofeng Ye; Wei Mou; Liyuan Kang

    2013-01-01

    OBJECTIVE: To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia.DATA RETRIEVAL: We retrieved publications from Cochrane Library (2004 to July 2011), PubMed (1966 to July 2011), the Chinese Science and Technique Journals Database (1977 to July 2011), the China National Knowledge Infrastructure (1979 to July 2011), Google Scholar (July 2011), and the Chinese Biomedical Database (1977 to July 2011) using the key words "Chinese medicine OR Chinese herbal medicine" and "vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia".MAIN OUTCOME MEASURES: Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions.CONCLUSION: Chinese herbal medicine appears to be safer and more effective than control measures in the treatment of vascular dementia. However, the included trials were generally low in quality. More well-designed, high-quality trials are needed to provide better evidence for the assessment of the efficacy and safety of Chinese medicines for vascular dementia.

  3. Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders.

    Science.gov (United States)

    Teschke, Rolf; Wolff, Albrecht; Frenzel, Christian; Eickhoff, Axel; Schulze, Johannes

    2015-04-21

    Herbal traditional Chinese medicine (TCM) is used to treat several ailments, but its efficiency is poorly documented and hence debated, as opposed to modern medicine commonly providing effective therapies. The aim of this review article is to present a practical reference guide on the role of herbal TCM in managing gastrointestinal disorders, supported by systematic reviews and evidence based trials. A literature search using herbal TCM combined with terms for gastrointestinal disorders in PubMed and the Cochrane database identified publications of herbal TCM trials. Results were analyzed for study type, inclusion criteria, and outcome parameters. Quality of placebo controlled, randomized, double-blind clinical trials was poor, mostly neglecting stringent evidence based diagnostic and therapeutic criteria. Accordingly, appropriate Cochrane reviews and meta-analyses were limited and failed to support valid, clinically relevant evidence based efficiency of herbal TCM in gastrointestinal diseases, including gastroesophageal reflux disease, gastric or duodenal ulcer, dyspepsia, irritable bowel syndrome, ulcerative colitis, and Crohn's disease. In conclusion, the use of herbal TCM to treat various diseases has an interesting philosophical background with a long history, but it received increasing skepticism due to the lack of evidence based efficiency as shown by high quality trials; this has now been summarized for gastrointestinal disorders, with TCM not recommended for most gastrointestinal diseases. Future studies should focus on placebo controlled, randomized, double-blind clinical trials, herbal product quality and standard criteria for diagnosis, treatment, outcome, and assessment of adverse herb reactions. This approach will provide figures of risk/benefit profiles that hopefully are positive for at least some treatment modalities of herbal TCM. Proponents of modern herbal TCM best face these promising challenges of pragmatic modern medicine by bridging the gap

  4. Hybrid de novo genome assembly of the Chinese herbal plant danshen (Salvia miltiorrhiza Bunge)

    OpenAIRE

    Zhang, Guanghui; Tian, Yang; Zhang, Jing; Shu, Liping; Yang, Shengchao; Wang, Wen; Sheng, Jun; Dong, Yang; Chen, Wei

    2015-01-01

    Background Danshen (Salvia miltiorrhiza Bunge), also known as Chinese red sage, is a member of Lamiaceae family. It is valued in traditional Chinese medicine, primarily for the treatment of cardiovascular and cerebrovascular diseases. Because of its pharmacological potential, ongoing research aims to identify novel bioactive compounds in danshen, and their biosynthetic pathways. To date, only expressed sequence tag (EST) and RNA-seq data for this herbal plant are available to the public. We t...

  5. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

    OpenAIRE

    Fang-Pey Chen; Maw-Shiou Jong; Yu-Chun Chen; Yen-Ying Kung; Tzeng-Ji Chen; Fun-Jou Chen; Shinn-Jang Hwang

    2011-01-01

    Chinese herbal medicine (CHM) has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM) outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Dis...

  6. Evaluation of Antioxidant and Antimicrobial Activities from 28 Chinese Herbal Medicines

    OpenAIRE

    Ho-Yang Lin; Li-Yeh Chuang; Hsueh-Wei Chang; Cheng-Hong Yang

    2013-01-01

    Background: Many Chinese medicines have been reported to exhibit high antimicrobial and antioxidantactivities. In this study, 28 traditional Chinese herbal medicines were tested for their antioxidant and antibacterial activities.Materials and Methods: Total flavonoid content of the ethanol extracts were determined by a colorimetric method. Total phenol content was estimated as gallic acid equivalents. The antioxidant activities of the extracts were evaluated by various antioxidant assays, inc...

  7. CLINICAL OBSERVATION ON TREATMENT OF CHRONIC PHARYNGITIS WITH ACUPUNCTURE PLUS CHINESE HERBAL MEDICINES

    Institute of Scientific and Technical Information of China (English)

    聂荣华

    2003-01-01

    @@ Chronic pharyngitis is the diffuse inflammation of the pharyngeal mucus, submucosal and lymph tissues. Traditional Chinese medicine (TCM) considers it to be the category of "Meiheqi" (梅核气,globus hystericus), "Shiyin" (失音,aphonia) and "Houbi" (喉痹,inflammation of the throat). According to the theory of TCM, the author of the present paper adopted acupuncture plus Chinese herbal medicines to treat it from 1990 to 2002, and achieved a satisfactory result. It is reported as follows.

  8. Chinese herbal medicine and acupuncture for the treatment of cardiovascular disease

    Institute of Scientific and Technical Information of China (English)

    Jun Xu; Haiyun Wu

    2009-01-01

    @@ Traditional Chinese medicine (TCM) is one of the world's oldest healing systems. TCM includes herbal medicine, acupuncture, moxibustion, massage, food therapy, and physical exercise, such as shadow boxing. In modern China, TCM is a fully institutionalised part of health care and widely used with Western medicine.

  9. Acute hepatitis in a patient using a Chinese herbal tea - a case report

    NARCIS (Netherlands)

    Levi, M; Guchelaar, HJ; Woerdenbag, HJ

    1998-01-01

    A case is presented of reversible acute hepatitis in a patient using a Chinese herbal tea. Upon identification of the tea mixture Aristolochia species, including A. debilis, which contains the highly toxic aristolochic acid, could be identified. We conclude that the acute hepatitis as described in t

  10. Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    Chun Ho Ma; Wai Ling Lin; Sing Leung Lui; Xun-Yuan Cai; Vivian Taam Wong; Eric Ziea; Zhang-Jin Zhang

    2013-01-01

    Chinese herbal medicine is commonly used as a treatment for benign prostatic hyperplasia (BPH),but its efficacy and safety remain to be examined.To compare the efficacy and adverse events of Chinese herbal medicine alone or used adjuvantly with Western medications for BPH.Two independent reviewers searched the major electronic databases for randomized controlled trials comparing Chinese herbal medicine,either in single or adjuvant use with Western medication,with placebo or Western medication.Relevant journals and grey literature were also hand-searched.The outcome measures included changes in urological symptoms,urodynamic measures,prostate volume and adverse events.The frequency of commonly used herbs was also identified.Out of 13 922 identified citations of publications,31 studies were included.Eleven studies with a Jadad score ≥ 3 were selected for meta-analysis.Chinese herbal medicine was superior to Western medication in improving quality of life and reducing prostate volume.The frequency of adverse events in Chinese herbal medicine was similar to that of placebo and less than that of Western medication.The evidence is too weak to support the efficacy of Chinese herbal medicine for BPH due to the poor methodological quality and small number of trials included.The commonly used herbs identified here should provide insights for future clinical practice and research.Larger randomized controlled trials of better quality are needed to truly evaluate the efficacy of Chinese herbal medicine.

  11. Green Restaurant: An Ancient Touch of Chinese Herbal Food

    Institute of Scientific and Technical Information of China (English)

    Ambra Schillirò

    2010-01-01

    @@ The first time Ⅰ entered the restaurant Green,inside the five-star Radegast Lake View Hotel in Chongwen District of Beijing,I was incredibly surprised.All around were red lights,a room reminiscent of the splendor of ancient China and simply delicious herbal cuisine.

  12. Green Restaurant: An Ancient Touch of Chinese Herbal Food

    Institute of Scientific and Technical Information of China (English)

    Ambra; Schilliro

    2010-01-01

    The first time I entered the restaurant Green, inside the five-star Radegast Lake View Hotel in Chongwen District of Beijing, I was incredibly surprised. All around were red lights, a room reminiscent of the splendor of ancient China and simply delicious herbal cuisine.

  13. [Prescription rules of Chinese herbal medicines in treatment of gastric cancer].

    Science.gov (United States)

    Cao, Wen; Zhao, Ai-guang

    2009-01-01

    Analysis of the nature, tastes, channel distributions and effects of the frequently used herbal medicines in the prescriptions involved in the clinical literatures about treatment of gastric cancer published from 1988 to 2007 was made in the paper. The literatures were categorized into three types: 1) treatment of middle- and late-stage gastric cancer; 2) prevention and treatment of the recurrence and metastasis after operation; 3) Chinese herbal medicines combined with chemotherapy for enhancing efficacy and reducing toxicity. The most frequently used herbal medicines in the three literature types were qi-invigorating herbs, such as Atractylodes, Astragalus, Codonopsis, Glycyrrhiza and Ginseng, etc. The herbal medicines for promoting urination to subside swelling such as tuckahoe and Semen Coicis, etc were used more frequently than the herbal medicines for regulating qi such as dried orange peel and putchuck, etc, as well as for clearing away heat to remove toxin such as spreading hedyotis herb, Herba Scutellariae Barbatae, yangtao actinidia root, and Rhizoma Paridis, etc. From another angle, the most frequently used herbal medicines for the treatment of gatric cancer were those cold, warm and neutral in nature, sweet, bitter and pungent in taste, and distributed to spleen and liver channels. PMID:19134451

  14. Targeting cancer-related inflammation: Chinese herbal medicine inhibits epithelial-to-mesenchymal transition in pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Juan Zhang

    Full Text Available Pancreatic cancer is an almost universally fatal disease resulting from early invasion of adjacent structures and metastasis and the lack of an effective treatment modality. Our previous studies have shown that Qingyihuaji Formula (QYHJ, a seven-herb Chinese medicine formula, had significant anti-cancer effects in pancreatic cancer. Here, we examined the effects of QYHJ on pancreatic cancer cell invasion and metastasis and the potential associated mechanism(s. We found that QYHJ inhibited both tumor growth and metastasis in nude mice with human pancreatic cancer cell xenografts. Further study indicated that QYHJ inhibited epithelial-to-mesenchymal transition (EMT, which is characterized by increased E-cadherin expression and decreased vimentin, N-cadherin and Slug expression. Interleukin 6 (IL-6, a pro-inflammatory cytokine produced mainly by macrophages, could promote cancer cell EMT and invasion. In contrast, treatment with QYHJ inhibited cancer-related inflammation in tumors by decreasing infiltration of tumor-associated macrophages and IL-6 production, thus preventing cell invasion and metastasis. These results suggested that the Chinese herbal medicine QYHJ could inhibit pancreatic cancer cell invasion and metastasis in part by reversing tumor-supporting inflammation.

  15. Progress of Research in Treatment of Hyperlipidemia by Monomer or Compound Recipe of Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    DOU Xiao-bing; WO Xing-de; FAN Chun-lei

    2008-01-01

    Hyperlipidemia (HLP) is the No.1 risk factor for patients with atherosclerosis (AS) and is directly related to the occurrence of coronary artery disease (CAD) and cerebrovascular disease. Therefore, prevention and treatment of AS is of great importance and of practical significance in controlling the incidence and mortality of CAD. With its peculiar syndrome-dependent therapy, traditional Chinese medicine (TCM) has accumulated abundant practical experiences in this field and good clinical effects have been achieved. Chinese herbal medicine, with its particularly unique advantages and high potentials yet to be tapped, displays its huge strength in HLP prevention and treatment. The progress of studies concerning prevention and treatment of HLP by Chinese herbal medicines, in the form of monomers or compound recipes, is reviewed in this paper.

  16. Traditional Chinese medicine herbal preparations in restless legs syndrome (RLS) treatment: a review and probable first description of RLS in 1529.

    Science.gov (United States)

    Yan, Xue; Wang, Wei-Dong; Walters, Arthur S; Wang, Qi; Liu, Yan-Jiao; Chu, Fu-Yong

    2012-12-01

    Occidental medicine has a given definition for restless legs syndrome (RLS) and knowledge of RLS pathophysiology has led to the development of its therapeutic management. RLS has no cure. Many methods have been used for its treatment, among which traditional Chinese medicine (TCM) has been considered as a new approach. However, description and management of the disease symptoms can be found in Chinese ancient medical systems. The first mention of RLS may have been as early as the third century BC described as "leg uncomfortable". Nonetheless, the lack of a complete description encompassing all four modern cardinal features of RLS makes this uncertain. On the other hand, the first description of RLS encompassing three of the four major modern criteria occurs in the ancient book of Neike Zhaiyao (Internal summary), 1529 AD just about a century and a half prior to the description of RLS by Sir Thomas Willis in England. Here, we introduce the philosophical concepts of traditional Chinese medicine and the description, classification and understanding of RLS symptoms in traditional Chinese medicine. We have conducted an in-depth review of the literature reporting one part of TCM, Chinese herbal treatment efficacy for RLS, through both English and Chinese search engines. Eighty-five studies were included in the review and more than 40 formulas (including 176 different ingredients) were found in the literature. According to the literature, Chinese herbs have been demonstrated to be safe and hold great potential to be an effective treatment modality for RLS, but the evidence is limited by the quality of these studies. Of the eighty-five studies, only nine were clinical trials with a control group and only three of them were randomized. In cases where herbal preparations were compared to Western medications for RLS, the herbal preparations appear to be superior. However, uncertainty as to whether the diagnosis of RLS was made in accord with Western norms and the use of

  17. The Role of the European Pharmacopoeia (Ph Eur in Quality Control of Traditional Chinese Herbal Medicine in European Member States

    Directory of Open Access Journals (Sweden)

    Mei Wang

    2015-01-01

    Full Text Available In order to assure the safety and efficacy of the Chinese Medicines in Europe, the quality of TCM herbals should be guaranteed so that they can be freely imported in the European Union and other Western European Countries which are signatories of the European Pharmacopoeia Convention. Consequently, new Ph Eur TCM herbal drug Monographs should be elaborated, based on preexisting Monographs in the Chinese Pharmacopoeia (ChP 2010.

  18. Evaluating the Bone Tissue Regeneration Capability of the Chinese Herbal Decoction Danggui Buxue Tang from a Molecular Biology Perspective

    OpenAIRE

    Wen-Ling Wang; Shi-Yuan Sheu; Yueh-Sheng Chen; Shung-Te Kao; Yuan-Tsung Fu; Tzong-Fu Kuo; Kuo-Yu Chen; Chun-Hsu Yao

    2014-01-01

    Large bone defects are a considerable challenge to reconstructive surgeons. Numerous traditional Chinese herbal medicines have been used to repair and regenerate bone tissue. This study investigated the bone regeneration potential of Danggui Buxue Tang (DBT), a Chinese herbal decoction prepared from Radix Astragali (RA) and Radix Angelicae Sinensis (RAS), from a molecular biology perspective. The optimal ratio of RA and RAS used in DBT for osteoblast culture was obtained by colorimetric and a...

  19. A Survey of the Studies on Compatible Law of Ingredients in Chinese Herbal Prescriptions

    Institute of Scientific and Technical Information of China (English)

    Wei Guoli; Zheng Xuebao

    2008-01-01

    @@ To prescribe a Chinese herbal prescription for the patient is the main thing done by the doctor in TCM clinic,and also an important link in TCM difierential treatment.The key point in the study of TCM prescriptions is the compatibility of Jaerbal ingredients in a prescription.To reveal the compatible law of TCM prescriptions is an important component part for TCM modernization.The following is a brief account on this kind of studies.

  20. NINETY-THREE CASES OF GASTROPTOSIS TREATED BY ACUPUNCTURE COMBINED WITH CHINESE HERBAL MEDICINE

    Institute of Scientific and Technical Information of China (English)

    HAN Xin-qiang; HAN Bao-ru; HAN Yan-ru

    2006-01-01

    @@ Gastroptosis refers to prolapse of the stomach to an abnormal position manifested clinically by distending pain below the xiphoid process, hypochondriac fullness, chest stuffiness, abdominal distention and straining sensation,which is mainly caused by reduced tensity, lack of fat of the abdominal wall, relaxed muscles and decreased abdominal pressure. The authors have treated 93 cases of gastroptosis by applying acupuncture combined with Chinese herbal medicine and achieved quite satisfactory therapeutic results reported as follows.

  1. Heavy Metal and Pesticide Content in Commonly Prescribed Individual Raw Chinese Herbal Medicines

    OpenAIRE

    HARRIS, Eric S. J.; Cao, Shugeng; Littlefield, Bruce A.; Craycroft, Jane A.; Scholten, Robert; KAPTCHUK, Ted; Fu, Yanling; Wang, Wenquan; Liu, Yong; Chen, Hubiao; Zhao, Zhongzhen; Clardy, Jon; Woolf, Alan D.; Eisenberg, David M.

    2011-01-01

    Heavy metal and pesticide contamination has previously been reported in Chinese Herbal Medicines (CHMs), in some cases at potentially toxic levels. This study was conducted to determine general patterns and toxicological significance of heavy metal and pesticide contamination in a broad sample of raw CHMs. Three-hundred-thirty-four samples representing 126 species of CHMs were collected throughout China and examined for arsenic, cadmium, chromium, lead, and mercury. Of the total, 294 samples ...

  2. 50 Cases of Pointed Condyloma Treated by Surgery Combined with External Washing with Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    杨小毛; 曾佳; 龙亚军

    2001-01-01

    @@ Pointed condyloma in the anus is caused by a virus of human papilloma, marked by the presence of rapidly growing cutaneous verrucae with itching, mild pain and offensive secretion. Diagnosis can be made based on biopsy. The disease is of high recurrence and very difficult to be cured radically. The author combined surgery with external washing with Chinese herbal medicine and achieved quite good results. The following is report of the treatment.

  3. Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington’s disease via suppressing oxidative stress, inflammation, and apoptosis

    Directory of Open Access Journals (Sweden)

    Lin CL

    2015-07-01

    Full Text Available Ching-Lung Lin,1 Sheue-Er Wang,2 Chih-Hsiang Hsu,1 Shuenn-Jyi Sheu,3 Chung-Hsin Wu1 1Department of Life Science, National Taiwan Normal University, Taipei, 2Department of Pathological Inspection, Soeurs de Saint Paul de Chartres Medical Corporate Body, Taoyuan City, 3Brion Research Institute of Taiwan, New Taipei City, Taiwan Abstract: Cardiac failure is often observed in aging patients with Huntington’s disease (HD. However, conventional pharmacological treatments for cardiac failure in HD patients have rarely been studied. Chinese herbal medicines, especially combined herbal formulas, have been widely used to treat cardiac dysfunctions over the centuries. Thus, we assess whether oral treatment with herbal formula B307 can alleviate cardiac failure in transgenic mice with HD. After oral B307 or vehicle treatment for 2 weeks, cardiac function and cardiomyocytes in 12-week-old male R6/2 HD mice and their wild-type littermate controls (WT were examined and then compared via echocardiography, immunohistochemistry, and Western blotting. We found that cardiac performance in aging R6/2 HD mice had significantly deteriorated in comparison with their WT (P<0.01. Cardiac expressions of superoxide dismutase 2 (SOD2 and B-cell lymphoma 2 (Bcl-2 in aging R6/2 HD mice were significantly lower than their WT (P<0.01, but cardiac expressions of tumor necrosis factor alpha (TNF-α, neurotrophin-3 (3-NT, 4-hydroxynonenal (4-HNE, Bcl-2-associated X protein (Bax, calpain, caspase 12, caspase 9, and caspase 3 of aging R6/2 HD mice were significantly higher than their WT (P<0.05. Furthermore, we found that cardiac performance in aging R6/2 HD mice had significantly improved under oral B307 treatment (P<0.05. Cardiac expressions of SOD2 and Bcl-2 of aging R6/2 HD mice were significantly higher under oral B307 treatment (P<0.01, but cardiac expressions of TNF-α, 3-NT, 4-HNE, Bax, calpain, caspase 12, caspase 9, and caspase 3 of aging R6/2 HD mice were significantly

  4. Chinese Herbal tea brand positioning Strategy : Case study: WONG LO KAT Herbal Tea

    OpenAIRE

    Wan, Shanshan

    2015-01-01

    With the Chinese reformation and opening-up, the domestic beverage industries got into a new period of development. The market also entered a booming period. The domestic beverage enterprises faced with opportunities and challenges that came from different aspects, and inter-brand competition also became more seriously. How to identify the brand's market positioning, determine the brand's competitive advantage, and develop relevant marketing strategies is the subject which needs to have atten...

  5. [Herbal textual research on origin and development of traditional Chinese medicine "duhuo" and "qianghuo"].

    Science.gov (United States)

    Shan, Feng; Yuan, Yuan; Hao, Jin-Da; Huang, Lu-Qi

    2014-09-01

    To clarify the origin and development of the traditional Chinese medicine "Duhuo" and "Qianghuo" with medicinal literatures. Medical literatures of past dynasties were analysed and combined with the modern material. The "Duhuo" in Herbal writing Shen Nong Ben Cao Jing include traditional Chinese medicine "Duhuo" and "Qianghuo", "Qianghuo" was separated from "Duhuo" due to the distinguish of clinical application. The origin of "Qianghuo" is Notopterygium incisum and N. forbesii, However, The origin of "Duhuo" is very complex, Angelica pubescens f. biserrata as authentic "Duhuo" was used from Song Dynasty. "Qianghuo" was originated from "Duhuo". PMID:25522638

  6. Research advances on the anti-aging profile of Fructus lycii: An ancient Chinese herbal medicine

    OpenAIRE

    Sze, SCW; Chang, RCC; Zhang, KY; Tong, Y; Song, J.; Wong, RNS

    2008-01-01

    Fructus lycii is a common Chinese herbal medicine used in China for nearly 2000 years. It has beneficial effects on eyes, liver and kidneys; and it has long been considered to be an anti-aging herb in ancient Chinese medicine. Modern studies have partially probed the magic anti-aging property of F. lycii. The beneficial effects of F. lycii on aging are largely attributed to its bioactive components such as polysaccharides, carotenoids and flavonoids. This review focuses on the anti-aging aspe...

  7. Chinese Herbal Medicine in Treatment of Polyhydramnios:a Meta-analysis and Systematic Review

    Institute of Scientific and Technical Information of China (English)

    Fen Zhou; Yu-fang Hao; Yan Chen; Tong Wang

    2013-01-01

    Objective Tocompare the efficacy of Chinese herbal medicine (therapy A) or Chinese herbal medicine plus indomethacin (therapy B) with that of indomethacin alone (therapy C) in treating polyhydramnios.MethodsLiteratures published up toApril 2012 were retrieved from PubMed, Embase and Cochranelibrary, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific and Technological Periodical Database (VIP), Wangfang, and Traditional Chinese Medicine online.Two researchers collected data independently.The assessment of methodological quality was based on Cochrane handbook and the materials were analyzed with software RevMan 5.1.2. The outcome measure index was relative risk or difference ofmean value (95% confidence interval). The following outcomes were evaluated: (1) general clinical improvement rate; (2) maximum vertical pocket depth; (3) amniotic fluid index (AFI) value; (4) rate of fetalductus arteriosus constriction; (5) incidence of adverse events.ResultsBased on the search strategy, 5 trails involving 1017 patients were finally included. Comparedwith therapy C, therapy A decreased the rate of fetal ductus arteriosus constriction (P<0.01). Therapy B was more effective than therapy C in general clinical improvement and decrease of AFI for polyhydramnios (P<0.01). No serious adverse events were reported in therapy A and therapy B.ConclusionsCompared with therapy C, therapy A and therapy B may appear to be moreeffective for polyhydramnios. However, the exact effectneeds to beconfirmed with well-designedlarge-scale clinical trials.

  8. New Chinese Herbal Product Launched in the US

    Institute of Scientific and Technical Information of China (English)

    Greg; Jones

    2009-01-01

    A new form of Chinese medicine that has dominated the Japanese OTC herb market for decades is now available in the U.S.The new medicines,called"Prime Herbs Granules",are produced through a process involving strict controls and advanced technology at every stage.Nevertheless,consumers agree that the benefits are worth

  9. Chinese Herbal Medicine Image Recognition and Retrieval by Convolutional Neural Network.

    Science.gov (United States)

    Sun, Xin; Qian, Huinan

    2016-01-01

    Chinese herbal medicine image recognition and retrieval have great potential of practical applications. Several previous studies have focused on the recognition with hand-crafted image features, but there are two limitations in them. Firstly, most of these hand-crafted features are low-level image representation, which is easily affected by noise and background. Secondly, the medicine images are very clean without any backgrounds, which makes it difficult to use in practical applications. Therefore, designing high-level image representation for recognition and retrieval in real world medicine images is facing a great challenge. Inspired by the recent progress of deep learning in computer vision, we realize that deep learning methods may provide robust medicine image representation. In this paper, we propose to use the Convolutional Neural Network (CNN) for Chinese herbal medicine image recognition and retrieval. For the recognition problem, we use the softmax loss to optimize the recognition network; then for the retrieval problem, we fine-tune the recognition network by adding a triplet loss to search for the most similar medicine images. To evaluate our method, we construct a public database of herbal medicine images with cluttered backgrounds, which has in total 5523 images with 95 popular Chinese medicine categories. Experimental results show that our method can achieve the average recognition precision of 71% and the average retrieval precision of 53% over all the 95 medicine categories, which are quite promising given the fact that the real world images have multiple pieces of occluded herbal and cluttered backgrounds. Besides, our proposed method achieves the state-of-the-art performance by improving previous studies with a large margin.

  10. Chinese Herbal Medicine Image Recognition and Retrieval by Convolutional Neural Network.

    Directory of Open Access Journals (Sweden)

    Xin Sun

    Full Text Available Chinese herbal medicine image recognition and retrieval have great potential of practical applications. Several previous studies have focused on the recognition with hand-crafted image features, but there are two limitations in them. Firstly, most of these hand-crafted features are low-level image representation, which is easily affected by noise and background. Secondly, the medicine images are very clean without any backgrounds, which makes it difficult to use in practical applications. Therefore, designing high-level image representation for recognition and retrieval in real world medicine images is facing a great challenge. Inspired by the recent progress of deep learning in computer vision, we realize that deep learning methods may provide robust medicine image representation. In this paper, we propose to use the Convolutional Neural Network (CNN for Chinese herbal medicine image recognition and retrieval. For the recognition problem, we use the softmax loss to optimize the recognition network; then for the retrieval problem, we fine-tune the recognition network by adding a triplet loss to search for the most similar medicine images. To evaluate our method, we construct a public database of herbal medicine images with cluttered backgrounds, which has in total 5523 images with 95 popular Chinese medicine categories. Experimental results show that our method can achieve the average recognition precision of 71% and the average retrieval precision of 53% over all the 95 medicine categories, which are quite promising given the fact that the real world images have multiple pieces of occluded herbal and cluttered backgrounds. Besides, our proposed method achieves the state-of-the-art performance by improving previous studies with a large margin.

  11. Chinese Herbal Medicine Image Recognition and Retrieval by Convolutional Neural Network.

    Science.gov (United States)

    Sun, Xin; Qian, Huinan

    2016-01-01

    Chinese herbal medicine image recognition and retrieval have great potential of practical applications. Several previous studies have focused on the recognition with hand-crafted image features, but there are two limitations in them. Firstly, most of these hand-crafted features are low-level image representation, which is easily affected by noise and background. Secondly, the medicine images are very clean without any backgrounds, which makes it difficult to use in practical applications. Therefore, designing high-level image representation for recognition and retrieval in real world medicine images is facing a great challenge. Inspired by the recent progress of deep learning in computer vision, we realize that deep learning methods may provide robust medicine image representation. In this paper, we propose to use the Convolutional Neural Network (CNN) for Chinese herbal medicine image recognition and retrieval. For the recognition problem, we use the softmax loss to optimize the recognition network; then for the retrieval problem, we fine-tune the recognition network by adding a triplet loss to search for the most similar medicine images. To evaluate our method, we construct a public database of herbal medicine images with cluttered backgrounds, which has in total 5523 images with 95 popular Chinese medicine categories. Experimental results show that our method can achieve the average recognition precision of 71% and the average retrieval precision of 53% over all the 95 medicine categories, which are quite promising given the fact that the real world images have multiple pieces of occluded herbal and cluttered backgrounds. Besides, our proposed method achieves the state-of-the-art performance by improving previous studies with a large margin. PMID:27258404

  12. Study on the mechanism of regulation on peritoneal lymphatic stomata with Chinese herbal medicine

    Institute of Scientific and Technical Information of China (English)

    Shi-Ping Ding; Ji-Cheng Li; Jian Xu; Lian-Gen Mao

    2002-01-01

    AIM: To study the mechanism of Chinese herbal medicine(CHM), the prescription consists of Radix SalviaeMiltiorrhizae , Radix Codonopsitis Pilosulae , RhizornaAtractylodis Alba and Rhizoma Alismatis, LeonurusHeterophyllus Sweet, etc ) on the regulation of theperitoneal lymphatic stomata and the ascites drainage.METHODS: The mouse model of live fibrosis wasestablished with the application of intragastric installationsof carbon tetrachloride once every three days; scanningelectron microscope and computer image processing wereused to detect the area and the distributive density of theperitoneal lymphatic stomata; and the concentrations ofurinary ion and NO in the serum were measured analyzed inthe experiment.RESULTS: Two different doses of CHM could significantlyincrease the area of the peritoneal lymphatic stomata,promote its distribution density and enhance the arainage ofurinary ion such as sodium, potassium and chlorine.Meanwhile, the NO concentration of two different doses ofCHM groups was 133.52 ± 23.57μmol/L, and 137.2 ±26.79μnol/L respectively. In comparison with the controland model groups ( 48.36 ± 6.83μmol/L, and 35.22 ±8.94μmol/L, P < 0.01 ), there existed significantly markeddifference, this made it clear that Chinese herbal medicinecould induce high endogenous NO concentration. The effectof Chinese herbal medicine on the peritoneal lymphaticstomata and the drainage of urinary ion was altered byadding NO donor (sodium nitropurruside, SNP) or NOsynthase (NOS) inhibitor (N(G)-monomethyl-L-arginine, L-NMMA) to the peritoneal cavity.CONCLUSION: There existed correlations between high NOconcentration and enlargement of the peritoneal lymphaticstomata, which result in enhanced drainage of ascites.These data supported the hypothesis that Chinese herbalmedicine could regulate the peritoneal lymphatic stomata byaccelerating the synthesis and release of endogenous NO.

  13. Classification of Mixtures of Chinese Herbal Medicines Based on a Self-organizing Map (SOM).

    Science.gov (United States)

    Wang, Maolin; Li, Li; Yu, Changyuan; Yan, Aixia; Zhao, Zhongzhen; Zhang, Ge; Jiang, Miao; Lu, Aiping; Gasteiger, Johann

    2016-04-01

    Chinese Herbal Medicines (CHMs) are typically mixtures of compounds and are often categorized into cold and hot according to the theory of Chinese Medicine. This classification is essential for guiding the clinical application of CHMs. In this study, three types of molecular descriptors were used to build models for classification of 59 CHMs with typical cold/hot properties in the training set taken from the original records on properties in China Pharmacopeia as reference. The accuracy and the Matthews correlation coefficient of the models were validated by a test set containing other 56 CHMs. The best model produced the accuracies of 94.92 % and 83.93 % on training set and test set, respectively. The MACCS fingerprint model is robust in predicting hot/cold properties of the CHMs from their major constituting compounds. This work shows how a classification model for data consisting of multi-components can be developed. The derived model can be used for the application of Chinese herbal medicines. PMID:27491920

  14. Are national quality standards for traditional Chinese herbal medicine sufficient? Current governmental regulations for traditional Chinese herbal medicine in certain Western countries and China as the Eastern origin country.

    Science.gov (United States)

    Dobos, G J; Tan, L; Cohen, M H; McIntyre, M; Bauer, R; Li, X; Bensoussan, A

    2005-09-01

    Traditional Chinese herbal Medicine (TCHM) has been gaining interest and acceptance world wide. TCHM provides on the one side promising perspective of scientific interest and on the other side possible health risks if TCHM drugs are not controlled with respect to quality standards or if practitioners for TCHM are not well trained. This paper outlines an introduction to the scientific aspects and potential risks of TCHM therapy followed by a brief, exploratory overview of the current status of TCHM regulations in certain Western countries like the USA, United Kingdom, Germany, Australia and in China as the Eastern origin country of TCHM. Legal foundations to establish quality and safety standards for TCHM crude drugs and ready-made formulas exist in some countries on a local basis but in practice are poorly enforced, where this products have no drug status. In addition practitioners treating patients with TCHM should be well versed in the pharmacology, side effects, and interactions of these substances with Western medicines and should be certified on a regular basis.

  15. Squamous Cell Carcinoma and Multiple Bowen's Disease in a Patient with a History of Consumption of Traditional Chinese Herbal Balls

    Directory of Open Access Journals (Sweden)

    Joon Seok

    2015-07-01

    Full Text Available Arsenic has been classified as a class I human carcinogen, meaning that there is sufficient evidence of carcinogenicity to humans. Arsenic, however, remains a common contaminant in a number of traditional Chinese herbal balls. A 64-year-old man presented with an erythematous erosive patch on the left palm, multiple yellowish scaly patches on the right palm and an erythematous hyperkeratotic patch with bleeding on the left foot dorsum. He also had similar skin lesions on the back and buttock. He had a past medical history of chronic exposure to arsenic through consumption of traditional Chinese herbal balls. Skin biopsy revealed Bowen's disease on the left palm and squamous cell carcinoma on left foot dorsum. We report this case to emphasize that we should investigate patient's history thoroughly, including the use of Chinese herbal balls to find out arsenicism.

  16. Effect of HT042, herbal formula, on longitudinal bone growth in spontaneous dwarf rats.

    Science.gov (United States)

    Kim, Ji Young; Song, MiKyung; Lee, Donghun; Song, Jungbin; Park, Sang Woug; Park, Juyeon; Park, Seungjoon; Choi, Ho-Young; Kim, Hocheol

    2013-01-01

    HT042 is a new herbal prescription consisting of Astragalus membranaceus, Phlomis umbrosa and Eleutherococcus senticosus, which are used in Korean medicine to stimulate growth in children. We investigated the effects of HT042 on the body weight, longitudinal bone growth, and bone length in spontaneous dwarf rats (SDR). Male and female SDRs were divided into three groups: the control group (DW, 10 mL/kg/day), the recombinant human GH group (rhGH; 500 µg/kg/day), and the HT042 (100 mg/kg/day) group. Each group received the respective treatments for 10 days. Body weight was measured on day 10 of treatment. On day 8, tetracycline (20 mg/kg) was injected intraperitoneally into all individuals to form a fluorescent band on the newly synthesized bone. On day 10, femur and tibia lengths were measured using PIXImus. Body weight, longitudinal bone growth, and bone length were not affected in the HT042 group. In contrast, the rhGH group showed significantly increased body weight, longitudinal bone growth, and bone length. In conclusion, HT042 does not act through a GH-like effect to promote longitudinal bone growth. PMID:24169467

  17. Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegansvia insulin signaling and stress response pathways

    OpenAIRE

    Young-Beob Yu; Laura Dosanjh; Lixing Lao; Ming Tan; Bum Sang Shim; Yuan Luo

    2010-01-01

    Background: Proving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the combination is assumed to be vitally important to the effectiveness of the herbal therapy. This issue may be addressed through the use of contemporary methodology and validated animal models. Methods and Principal Findings: In this ...

  18. Effects of Chinese herbal medicine on plasma glucose, protein and energy metabolism in sheep

    Institute of Scientific and Technical Information of China (English)

    Xi Liang; Kyota Yamazaki; Mohammad Kamruzzaman; Xue Bi; Arvinda Panthee; Hiroaki Sano

    2014-01-01

    Background:The use of antibiotics in animal diets is facing negative feedback due to the hidden danger of drug residues to human health. Traditional Chinese herbal medicine has been used to replace antibiotics in the past two decades and played an increasingly important role in livestock production. The present study was carried out to assess the feeding effects of a traditional nourishing Chinese herbal medicine mixture on kinetics of plasma glucose, protein and energy metabolism in sheep. Ruminal fermentation characteristics were also determined. Methods:Four sheep were fed on either mixed hay (MH-diet) or MH-diet supplemented with 2%of Chinese herbal medicine (mixture of Astragalus root, Angelica root and Atractylodes rhizome;CHM-diet) over two 35-day periods using a crossover design. The turnover rate of plasma glucose was measured with an isotope dilution method using [U-13C]glucose. The rates of plasma leucine turnover and leucine oxidation, whole body protein synthesis (WBPS) and metabolic heat production were measured using the [1-13C]leucine dilution and open circuit calorimetry. Results:Body weight gain of sheep was higher (P=0.03) for CHM-diet than for MH-diet. Rumen pH was lower (P=0.02), concentration of rumen total volatile fatty acid tended to be higher (P=0.05) and acetate was higher (P=0.04) for CHM-diet than for MH-diet. Turnover rates of plasma glucose and leucine did not differ between diets. Oxidation rate of leucine tended to be higher (P=0.06) for CHM-diet than for MH-diet, but the WBPS did not differ between diets. Metabolic heat production tended to be greater (P=0.05) for CHM-diet than for MH-diet. Conclusions:The sheep fed on CHM-diet had a higher body weight gain and showed positive impacts on rumen fermentation and energy metabolism without resulting in any adverse response. Therefore, these results suggested that the Chinese herbal medicine mixture should be considered as a potential feed additive for sheep.

  19. New Effective Treatment of Liver Fibrosis by Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    张国梁

    2002-01-01

    @@ Liver fibrosis is an abnormal proliferation pathologic process of intrahepatic fibrous connective tissue that occurs after liver cells have been necrotized and stimulated by inflammatory factors. It is called fibrosis when the pathological change is mild, and liver cirrhosis when the change becomes so severe as to reconstruct the liver lobuli to form pseudolobuli and nodule(1). Liver fibrosis is an important pathological characteristic of chronic hepatopathy and the chief intermediate link to further develop of liver cirrhosis. No ideal remedy for treatment of chronic hepatitic cirrhosis has been found so far. Although some drugs, such as colchicine and penicillamine, had been reported to have the effect of fibrosis inhibition, their clinical application is still limited for the rather severe toxic-side effects. Certain progress have been made from the clinical and experimental studies on anti-fibrosis treatment by traditional Chinese medicine (TCM) carried out widely in China in recent ten years. And here is a general review of the drugs used.

  20. Treatment of cholecystitis with Chinese herbal medicines: A systematic review of the literature

    Institute of Scientific and Technical Information of China (English)

    Zhi-Yong Dong; Guan-Liang Wang; Xing Liu; Jia Liu; De-Zeng Zhu; Chang-Quan Ling

    2012-01-01

    AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines (TCM) was analyzed based on the principles and methods described by evidence-based medicine (EBM).Eight databases including MEDLINE,EMbase,Cochrane Central (CCTR),four Chinese databases (China Biological Medicine Database,Chinese National Knowledge Infrastructure Database,Database of Chinese Science and Technology Periodicals,Database of Chinese Ministry of Science and Technology) and Chinese Clinical Registry Center,were searched.Full text articles or abstracts concerning TCM treatment of cholecystitis were selected,categorized according to study design,the strength of evidence,the first author's hospital type,and analyzed statistically.RESULTS:A search of the literature published from 1977 through 2009 yielded 1468 articles in Chinese and 9 in other languages; and 93.92% of the articles focused on clinical studies.No article was of level I evidence,and 9.26% were of level Ⅱ evidence.The literature cited by Science Citation Index (SCI),MEDLINE and core Chinese medical journals accounted for 0.41%,0.68% and 7.29%,respectively.Typically,the articles featured in case reports of illness,examined from the perspective of EBM,were weak in both quality and evidence level,which inconsistently conflicted with the fact that most of the papers were by authors from Level-3 hospitals,the highest possible level evaluated based on their comprehensive quality and academic authenticity in China.CONCLUSION:The published literature on TCM treatment of cholecystitis is of low quality and based on low evidence,and cognitive medicine may functions as a useful supplementary framework for the evaluation.

  1. Traditional Chinese Medicine (TCM and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs

    Directory of Open Access Journals (Sweden)

    Rolf Teschke

    2016-07-01

    Full Text Available Background: Traditional Chinese Medicine (TCM with its focus on herbal use is popular and appreciated worldwide with increased tendency, although its therapeutic efficacy is poorly established for most herbal TCM products. Treatment was perceived as fairly safe but discussions emerged more recently as to whether herb induced liver injury (HILI from herbal TCM is a major issue; Methods: To analyze clinical and case characteristics of HILI caused by herbal TCM, we undertook a selective literature search in the PubMed database with the search items Traditional Chinese Medicine, TCM, alone and combined with the terms herbal hepatotoxicity or herb induced liver injury; Results: HILI caused by herbal TCM is rare and similarly to drugs can be caused by an unpredictable idiosyncratic or a predictable intrinsic reaction. Clinical features of liver injury from herbal TCM products are variable, and specific diagnostic biomarkers such as microsomal epoxide hydrolase, pyrrole-protein adducts, metabolomics, and microRNAs are available for only a few TCM herbs. The diagnosis is ascertained if alternative causes are validly excluded and causality levels of probable or highly probable are achieved applying the liver specific RUCAM (Roussel Uclaf Causality Assessment Method as the most commonly used diagnostic tool worldwide. Case evaluation may be confounded by inappropriate or lacking causality assessment, poor herbal product quality, insufficiently documented cases, and failing to exclude alternative causes such as infections by hepatotropic viruses including hepatitis E virus infections; Conclusion: Suspected cases of liver injury from herbal TCM represent major challenges that deserve special clinical and regulatory attention to improve the quality of case evaluations and ascertain patients’ safety and benefit.

  2. Effects of Chinese herbal medicine Yiqi Huayu formula on substance P expression in skin ulcers of rats with diabetes mellitus%益气化瘀中药对糖尿病大鼠皮肤溃疡组织中P物质表达的影响

    Institute of Scientific and Technical Information of China (English)

    王云飞; 阙华发

    2011-01-01

    目的:探讨益气化瘀中药对糖尿病溃疡大鼠创面组织P物质表达的影响.方法:将100只清洁级雄性Sprague-Dawley大鼠随机分为正常创面组、模型组、益气组、化瘀组和益气化瘀组.制备糖尿病大鼠背部全层皮肤缺损开放性创面模型.各组分别给予生理盐水、益气中药、化瘀中药及益气化瘀中药灌胃处理,疗程为15d.用药第8及第15天,观察各组大鼠创面愈合率;用药15 d后,取大鼠背部创周0.5 cm以内组织,应用免疫组织化学技术检测P物质的表达水平,并计算免疫组织化学指数.结果:用药后第8及第15天,正常组创面愈合率明显高于模型组(P<0.01),各用药组创面愈合率明显高于模型组(P<0.05),且益气化瘀组明显高于各拆方组(P<0.05);模型组创面组织P物质的表达水平明显低于正常创面组(P<0.05),益气化瘀组和化瘀组P物质的表达水平明显高于模型组(P<0.05).结论:糖尿病创面难愈合可能与P物质的低表达有关.益气化瘀中药能明显促进耱尿病溃疡大鼠的创面愈合,上调P物质的表达水平可能是其作用机制之一.%Objective: To investigate the effects of Chinese herbs for replenishing qi (Yiqi) and dissolving stasis (Huayu) on substance P expression in granulation tissue of skin ulcers in rats with diabetes mellitus. Methods: One hundred male Sprague-Dawley rats with back full-thickness skin lesion were randomly divided into five groups: ulcer control group, diabetic ulcer group, Yiqi Huayu herb group, Yiqi herb group, and Huayu herb group. Except ulcer control group, the other rats were also injected streptozotocin to induce diabetes mellitus. Rats in each group were given normal saline or herbal drugs for 15 d and the wound healing rate of the rats was observed on days 8 and 15, respectively. After treatment, the expression of substance P in granulation tissues of the rats was tested with immunohistochemical method and the

  3. Effect of Chinese Herbal Medicine Combined with Acitretin Capsule in Treating Psoriasis of Blood-Heat Syndrome Type

    Institute of Scientific and Technical Information of China (English)

    张立新; 白彦萍; 宋佩华; 尤立平; 杨顶权

    2009-01-01

    Objective:To observe the clinical curative effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome(P-BH).Methods:Eighty patients of P-BH were randomly assigned to two groups,39 in Group A and 41 in Group B.Both was treated with Chinese herbal medicines for clearing heat,cooling blood and removing toxic substance,and acitretin capsule was given to Group A additionally,with 8 weeks as one therapeutic course.The clinical curative effect was compared bet...

  4. Theories and Practice in Prevention and Treatment Principles in Relation to Chinese Herbal Medicine and Bone Loss

    Institute of Scientific and Technical Information of China (English)

    Hong Xu 徐红; David LAWSON

    2004-01-01

    Osteoporosis is a world wide problem that is increasing in significance as the global population both increases and ages. While osteoporosis has been extensively studied in recent years, the utilization of Traditional Chinese Herbal Medicine for the prevention and treatment of this condition have seldom been examined in the Western world. This paper reviews the theories and the literature that relate to prevention and treatment of bone loss at the time of menopause according to the principles of Traditional Chinese Herbal Medicine. Practical developments in these areas are also illustrated in this paper based on the authors' research findings in recent studies.

  5. To Set Up a Logistic Regression Prediction Model for Hepatotoxicity of Chinese Herbal Medicines Based on Traditional Chinese Medicine Theory.

    Science.gov (United States)

    Liu, Hongjie; Li, Tianhao; Chen, Lingxiu; Zhan, Sha; Pan, Meilan; Ma, Zhiguo; Li, Chenghua; Zhang, Zhe

    2016-01-01

    Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs. Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square test for two-way unordered categorical data. LR prediction model was established and the accuracy of the prediction by this model was evaluated. Results. The hepatotoxic and nonhepatotoxic Chinese HMs were related with four properties (p 0.05). There were totally 12 variables from four properties and five flavors for the LR. Four variables, warm and neutral of the four properties and pungent and salty of five flavors, were selected to establish the LR prediction model, with the cutoff value being 0.204. Conclusions. Warm and neutral of the four properties and pungent and salty of five flavors were the variables to affect the hepatotoxicity. Based on such results, the established LR prediction model had some predictive power for hepatotoxicity of Chinese HMs.

  6. New Perspectives on Chinese Herbal Medicine (Zhong-Yao Research and Development

    Directory of Open Access Journals (Sweden)

    Si-Yuan Pan

    2011-01-01

    Full Text Available Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs remain time-consuming, capital-intensive and risky, much effort has been put in the search for alternative routes for drug discovery in China. This narrative review illustrates various approaches to the research and drug discovery in Chinese herbal medicine. Although this article focuses on Chinese traditional drugs, it is also conducive to the development of other traditional remedies and innovative drug discovery.

  7. New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development

    Science.gov (United States)

    Pan, Si-Yuan; Chen, Si-Bao; Dong, Hong-Guang; Yu, Zhi-Ling; Dong, Ji-Cui; Long, Zhi-Xian; Fong, Wang-Fun; Han, Yi-Fan; Ko, Kam-Ming

    2011-01-01

    Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs remain time-consuming, capital-intensive and risky, much effort has been put in the search for alternative routes for drug discovery in China. This narrative review illustrates various approaches to the research and drug discovery in Chinese herbal medicine. Although this article focuses on Chinese traditional drugs, it is also conducive to the development of other traditional remedies and innovative drug discovery. PMID:21785622

  8. A Herbal Formula, Atofreellage, Ameliorates Atopic Dermatitis-Like Skin Lesions in an NC/Nga Mouse Model.

    Science.gov (United States)

    Kim, Won-Yong; Kim, Hyeong-Geug; Lee, Hye-Won; Lee, Jin-Seok; Im, Hwi-Jin; Kim, Hyo-Seon; Lee, Sung-Bae; Son, Chang-Gue

    2015-01-01

    We evaluated the anti-atopic dermatitis (AD) effect of Atofreellage (AF), a herbal formula composed of 10 medicinal plants. AD was induced on the dorsal skin areas of NC/Nga mice (male, seven weeks old) by daily application of 2,4-dinitrochlorobenzene (DNCB) for five weeks. After three weeks of DNCB application, 200 μL of AF (0, 25, 50 or 100 mg/mL) was applied to the skin lesions. Histological findings, blood cell populations, serum levels of immunoglobulin E (IgE), histamine, pro-inflammatory cytokines, and inflammatory signaling in the skin tissue, and T-helper cell type 2 (Th₂)-related cytokines in splenocytes were analyzed. Histopathological findings showed AF treatment notably attenuated the thickness of dorsal skin, and eosinophil infiltration. AF treatment (especially 100 mg/mL) also demonstrably ameliorated the blood cell population abnormalities, as the notable elevation of serum concentrations of IgE, histamine, TNF-α, IL-6 and IL-1β were remarkably normalized by AF treatment. Western blot analysis evidenced the apparent normalization of inflammatory signals (ERK, p38 MAP kinase, JNK, and NF-κB) in the skin tissue. Additionally, AF treatment notably attenuated the activation of Th₂-dominant cytokines (IL-13, IL-4, and IL-5) in Con A-treated splenocytes in an ex vivo assay. In conclusion, this study provides experimental evidence for the clinical relevance of Atofreellage. PMID:26712731

  9. Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Ji Young Cha

    2013-01-01

    Full Text Available Pyungwi-san (PWS is a traditional basic herbal formula. We investigated the effects of PWS on induction of cyclooxygenase-2 (COX-2, inducible nitric oxide synthase (iNOS, pro-inflammatory cytokines (interleukin-6 (IL-6 and tumor necrosis factor-α (TNF-α and nuclear factor-kappa B (NF-κB as well as mitogen-activated protein kinases (MAPKs in lipopolysaccharide-(LPS- induced Raw 264.7 cells and on paw edema in rats. Treatment with PWS (0.5, 0.75, and 1 mg/mL resulted in inhibited levels of expression of LPS-induced COX-2, iNOS, NF-κB, and MAPKs as well as production of prostaglandin E2 (PGE2, nitric oxide (NO, IL-6, and TNF-α induced by LPS. Our results demonstrate that PWS possesses anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the signaling pathways of NF-κB and MAPKs in LPS-induced macrophage cells. More importantly, results of the carrageenan-(CA- induced paw edema demonstrate an anti-edema effect of PWS. In addition, it is considered that PWS also inhibits the acute edematous inflammations through suppression of mast cell degranulations and inflammatory mediators, including COX-2, iNOS and TNF-α. Thus, our findings may provide scientific evidence to explain the anti-inflammatory properties of PWS in vitro and in vivo.

  10. Hedyotis diffusa Combined with Scutellaria barbata Are the Core Treatment of Chinese Herbal Medicine Used for Breast Cancer Patients: A Population-Based Study

    Directory of Open Access Journals (Sweden)

    Yuan-Chieh Yeh

    2014-01-01

    Full Text Available Traditional Chinese medicine (TCM, which is the most common type of complementary and alternative medicine (CAM used in Taiwan, is increasingly used to treat patients with breast cancer. However, large-scale studies on the patterns of TCM prescriptions for breast cancer are still lacking. The aim of this study was to determine the core treatment of TCM prescriptions used for breast cancer recorded in the Taiwan National Health Insurance Research Database. TCM visits made for breast cancer in 2008 were identified using ICD-9 codes. The prescriptions obtained at these TCM visits were evaluated using association rule mining to evaluate the combinations of Chinese herbal medicine (CHM used to treat breast cancer patients. A total of 37,176 prescriptions were made for 4,436 outpatients with breast cancer. Association rule mining and network analysis identified Hedyotis diffusa plus Scutellaria barbata as the most common duplex medicinal (10.9% used for the core treatment of breast cancer. Jia-Wei-Xiao-Yao-San (19.6% and Hedyotis diffusa (41.9% were the most commonly prescribed herbal formula (HF and single herb (SH, respectively. Only 35% of the commonly used CHM had been studied for efficacy. More clinical trials are needed to evaluate the efficacy and safety of these CHM used to treat breast cancer.

  11. Hedyotis diffusa Combined with Scutellaria barbata Are the Core Treatment of Chinese Herbal Medicine Used for Breast Cancer Patients: A Population-Based Study.

    Science.gov (United States)

    Yeh, Yuan-Chieh; Chen, Hsing-Yu; Yang, Sien-Hung; Lin, Yi-Hsien; Chiu, Jen-Hwey; Lin, Yi-Hsuan; Chen, Jiun-Liang

    2014-01-01

    Traditional Chinese medicine (TCM), which is the most common type of complementary and alternative medicine (CAM) used in Taiwan, is increasingly used to treat patients with breast cancer. However, large-scale studies on the patterns of TCM prescriptions for breast cancer are still lacking. The aim of this study was to determine the core treatment of TCM prescriptions used for breast cancer recorded in the Taiwan National Health Insurance Research Database. TCM visits made for breast cancer in 2008 were identified using ICD-9 codes. The prescriptions obtained at these TCM visits were evaluated using association rule mining to evaluate the combinations of Chinese herbal medicine (CHM) used to treat breast cancer patients. A total of 37,176 prescriptions were made for 4,436 outpatients with breast cancer. Association rule mining and network analysis identified Hedyotis diffusa plus Scutellaria barbata as the most common duplex medicinal (10.9%) used for the core treatment of breast cancer. Jia-Wei-Xiao-Yao-San (19.6%) and Hedyotis diffusa (41.9%) were the most commonly prescribed herbal formula (HF) and single herb (SH), respectively. Only 35% of the commonly used CHM had been studied for efficacy. More clinical trials are needed to evaluate the efficacy and safety of these CHM used to treat breast cancer. PMID:24734104

  12. Optimization of the extraction process for the seven bioactive compounds in Yukmijihwang-tang, an herbal formula, using response surface methodology

    OpenAIRE

    Jung-Hoon Kim; Hyeun-Kyoo Shin; Chang-Seob Seo

    2014-01-01

    Background: Yukmijihwang-tang (YJT) contains multiple bioactive compounds. Heat-reflux extraction was employed and optimized for the extraction of the bioactive compounds in YJT. Objective: The determination of optimal conditions with maximum yields of bioactive compounds, gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, paeoniflorin, benzoic acid and paeonol, in YJT. Materials and Methods: The extraction ratio (ratio of water to herbal formula), extraction time and extraction numb...

  13. Chinese Herbal Medicine as Adjunctive Therapy to Chemotherapy for Breast Cancer: A Systematic Review and Meta-Analysis

    OpenAIRE

    Xu Sun; Xing Zhang; Jia-Yun Nian; Jiao Guo; Yi Yin; Gan-Lin Zhang; Ming-Wei Yu; Yi Zhang; Xiao-Min Wang; Guo-Wang Yang; Lin Yang; Pei-Yu Cheng; Jin-Ping Li

    2016-01-01

    Chinese herbal medicine (CHM) has been increasingly employed during therapy for breast cancer, but its efficacy remains a matter of debate. This systematic review examined randomized controlled trials to provide a critical evaluation of this treatment. The results demonstrated that the combined use of CHM with chemotherapy may improve the immediate tumor response and reduce chemotherapy-associated adverse events. Our findings highlight the poor quality of Chinese studies, and additional well-...

  14. Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines

    OpenAIRE

    Chai, Stella; To, Kenneth KW; Lin, Ge

    2010-01-01

    Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studie...

  15. Clinical study on treatment of rectal carcinoma with Chinese herbal medicine and high dose fluorouracil emulsion via rectal infusion.

    Institute of Scientific and Technical Information of China (English)

    王晨光

    1999-01-01

    Objective: To study the clinical significance of rectal infusion of Chinese herbal medicine (CHM) plus high dose fluorouracil emulsion in treating rectal carcinoma. Methods: 86 patients of rectal carcinoma were randomly divided into CHM plus chemotherapy group and single chemotherapy group, and the

  16. Fifty Cases of Child Restless Syndrome Treated with the Integrated Method of Chinese Herbal Drugs and Auricular-Plaster Therapy

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Fifty cases of child restless syndrome were treated with oral administration of Chinese traditional herbal drugs plus auricular-plaster therapy from December 1998 to November 2001, and another 47 cases were treated with oral administration of methylphenidate as controls. The result is reported as follows.

  17. Effect of Chinese Herbal Medicine Jinlida Granule in Treatment of Patients with Impaired Glucose Tolerance

    Science.gov (United States)

    Shi, Ya-Lin; Liu, Wen-Juan; Zhang, Xiao-Fang; Su, Wei-Juan; Chen, Ning-Ning; Lu, Shu-Hua; Wang, Li-Ying; Shi, Xiu-Lin; Li, Zhi-Bin; Yang, Shu-Yu

    2016-01-01

    Background: Diabetes mellitus (DM) remains a major health problem worldwide. Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM. This study aimed to evaluate the efficacy of Jinlida (JLD) granule, a Chinese herbal recipe, in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM. Methods: Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group, n = 34) or no drug intervention (control group, n = 31) for 12 weeks. Oral glucose tolerance test, glycated hemoglobin A1c (HbA1c), body mass index, blood lipids levels, fasting insulin, and insulin resistance calculated using homeostatic model assessment (HOMA-IR) of all the patients were observed and compared before and after the treatment. Results: Sixty-one participants completed the trial (32 in JLD group and 29 in the control group). There were statistically significant decreases in HbA1c (P < 0.001), 2-h plasma glucose (P < 0.001), and HOMA-IR (P = 0.029) in JLD group compared with the control group after 12 weeks of treatment. After 12 weeks of treatment, two (6.9%) patients returned to normal blood glucose, and five (17.2%) patients turned into DM in control group, while in the JLD group, 14 (43.8%) returned to normal blood glucose and 2 (6.2%) turned into DM. There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups (P = 0.001). Conclusions: JLD granule effectively improved glucose control, increased the conversion of IGT to normal glucose, and improved the insulin resistance in patients with IGT. This Chinese herbal medicine may have a clinical value for IGT. PMID:27647185

  18. Therapeutic strategies for Parkinson's disease: the ancient meets the future--traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells.

    Science.gov (United States)

    Wang, Xuan; Liang, Xi-Bin; Li, Feng-Qiao; Zhou, Hui-Fang; Liu, Xian-Yu; Wang, Jian-Jun; Wang, Xiao-Min

    2008-10-01

    In China, it has been estimated that there are more than 2.0 million people suffering from Parkinson's disease, which is currently becoming one of the most common chronic neurodegenerative disorders during recent years. For many years, scientists have struggled to find new therapeutic approaches for this disease. Since 1994, our research group led by Drs. Ji-Sheng Han and Xiao-Min Wang of Neuroscience Research Institute, Peking University has developed several prospective treatment strategies for the disease. These studies cover the traditional Chinese medicine-herbal formula or acupuncture, and modern technologies such as gene therapy or stem cell replacement therapy, and have achieved some original results. It hopes that these data may be beneficial for the research development and for the future clinical utility for treatment of Parkinson's disease.

  19. On Modernize Chinese Herbal Research%对中药现代化研究的几点思考

    Institute of Scientific and Technical Information of China (English)

    钟长军

    2012-01-01

    Chinese herbs through the development for thousands of years still twinkle in protecting people's health under the guidance of basic theory, but now it is in the embarrassing position going with modern medicine side by side-It seems that Chinese herbs can only used to treat chronic diseases or some difficult miscellaneous diseases. The reason was that the keys of modernize Chinese herbal research weren't grasped so that the effects couldn't be demonstrated fully, basically herbs were studied by the research mode of western medicine and the effects of herbs were explained with modern western medicinal theory, which caused the slow development of modernize Chinese herbal research. Therefore modernize Chinese herbal research should center on the effects, bringing the efficacy, safety and standard matched the features of herbs together, Chinese herbs of comparative advantage with western medicine should be investigated to promote the internationalization of herbs and heading for the world.%中药现代研究应以疗效为中心,将中药有效性研究,安全性研究、符合中药特点的质量标准体系三者结合起来,创新出一大批与西药有比较优势的中药,从而推动中药现代化,促进中药走向世界.

  20. Chinese Herbal Medicine for Aspirin Resistance: A Systematic Review of Randomized Controlled Trials

    Directory of Open Access Journals (Sweden)

    Ai-ju Liu

    2014-01-01

    Full Text Available Aspirin resistance (AR is a prevalent phenomenon and leads to significant clinical consequences, but the current evidence for effective interventional strategy is insufficient. The objective of this systematic review is thus to assess the efficacy and safety of Chinese herbal medicine (CHM for AR. A systematical literature search was conducted in 6 databases until December 2012 to identify randomized controlled trials (RCTs of CHM for AR. As a result, sixteen RCTs with a total of 1011 subjects were identified, suggesting that the interests of the medical profession and the public in the use of CHM for AR have grown considerably in the recent years. Tongxinluo capsule and Danshen-based prescriptions were the most frequently used herbal prescriptions, while danshen root, milkvetch root, Leech, and Rosewood were the most frequently used single herbs. Despite the apparent reported positive findings, it is premature to determine the efficacy and safety of CHM for the treatment of AR due to poor methodological quality and insufficient safety data. However, CHMs appeared to be well tolerated in all included studies. Thus, CHM as a promising candidate is worthy of improvement and development for further clinical AR trials. Large sample-size and well-designed rigorous RCTs are needed.

  1. Usage analysis of some package of Chinese herbal pieces in our hospital%小包装中药饮片在我院的使用情况分析

    Institute of Scientific and Technical Information of China (English)

    张献敏

    2015-01-01

    Some package of Chinese herbal pieces is the embodiment of specification and quality of Chinese herbal pieces,and improve formula model of traditional Chinese herbal pieces with accurate measurement,and it meets the needs of broad patients,and makes patients to enjoy the high quality service. There are many advantages of small pack-age pieces:improves the drug quality and accuracy rate of adjusting;easy to storage and identify;and controllable quality standardization of Chinese herbal;shelf type deposit and convenient management,but there are also many disadvantages of small package of traditional Chinese herbal pieces:the production cost of traditional Chinese herbal medicine pieces is increasing,pollution is the bad side of packaging material;it is not easy for Chinese medicine;it is not for young pharmacists mastering processing and identification method of traditional Chinese medicine pieces;small package of traditional Chinese herbal pieces in Chinese medicine cabinet for storage is not convenient;Chinese herbal medicine pieces and packaging material interacts.The promotion and development of small package of traditional Chinese medicine pieces is a systems project,the key is the source,it needs coordinated development of many aspects.%中药饮片小包装是中药饮片规格和质量的体现,改进了传统中药饮片的配方模式,计量准确,满足了广大患者的需求,使患者享受到了优质服务。小包装饮片的优点是提高了药品质量和调剂准确率;方便储存,易于识别;中药饮片质量标准的可控;货架式存放,便于管理,但中药饮片小包装也存在很多问题:中药饮片的生产成本增加,包装材料带来污染;不便于中医用药;不便于年轻中药师掌握中药饮片的炮制和鉴别方法;中药饮片小包装在中药橱里储存不方便;中药饮片与包装材料相互影响。中药小包装的推广和发展是一个系统工程,重点在

  2. Chinese Herbal Medicine in Folk Custom%民俗中的中草药略识

    Institute of Scientific and Technical Information of China (English)

    齐敏; 李春芳

    2009-01-01

    There are large amount of Chinese herbal medicine used in folk custom of our country. Most of these medicines are related with hygiene and health care. The usage of these medicine included avoiding dirty, preventing diseases, restoring convalescence, health protection, cosmetology, bathing, and daily effective medical prescription. Folk custom has the characteristics of regionality, consistency, and nationality,ete. Some of traditional Chinese medicine originates from folk custom. Therefore, the research of medicine used in folk custom may help to the development of traditional Chinese medicine.%在我国传统民俗中流传有大量中草药,其用途主要包括辟秽防病、康复保健、美容化妆、服饰佩物、洗浴、日常疗病等.民俗为群体性、倾向性的社会行为,并有地域性、传承性、历史性、民族性等特点,同时中草药中的一部分药物也来源于民俗,研究民俗中的药物可有助于研发中药新药.

  3. Microwave—assisted Extraction of Effective Compounds from Traditional Chinese Herbal Medicine Ciwujia

    Institute of Scientific and Technical Information of China (English)

    王娟; 沈平孃; 沈永嘉

    2003-01-01

    Microwave-assisted extraction (MAE) fro active ingredients in Ciweujia was studied by using ethanol as the extractant.Comparing MAE with conventional methods,the former can save the extracting time and increase the content of the active ingredients in product,As to the operation in MAE ,the continuous radiation process is more convenient for the extraction for traditional Chinese medicine than the intermittent radiation process,Optimized by uniform design,MAE was proved to be an effective and novel process for extracting active ingredients in Ciwujia,The optimized MAE conditions are as follows:the microwave power is 510W,the radiation time 30 min the alohol concentration at 80%,the ratio of solvent to soild material being 5:1,the soaking time 0.5h ,and the herbal particle size is (520±19)μm.

  4. Arsenic speciation in Chinese Herbal Medicines and human health implication for inorganic arsenic.

    Science.gov (United States)

    Liu, Xiao-Juan; Zhao, Quan-Li; Sun, Guo-Xin; Williams, Paul; Lu, Xiu-Jun; Cai, Jing-Zhu; Liu, Wen-Ju

    2013-01-01

    Rice and drinking water are recognized as the dominant sources of arsenic (As) for human intake, while little is known about As accumulation and speciation in Chinese Herbal Medicines (CHMs), which have been available for many hundreds of years for the treatment of diseases in both eastern and western cultures. Inorganic arsenic was the predominant species in all of CHMs samples. The levels of inorganic arsenic in CHMs from fields and markets or pharmacies ranged from 63 to 550 ng/g with a mean of 208 ng/g and 94 to 8683 ng/g with a mean of 1092 ng/g, respectively. The highest concentration was found in the Chrysanthemum from pharmacies. It indicates that the risk of inorganic As in CHMs to human health is higher in medicines from markets or pharmacies than that collected directly from fields. Some CHMs may make a considerable contribution to the human intake of inorganic arsenic.

  5. [Liu Yue-heng and Shengcaoyaoxingfangpu (Guidebook of Chinese medicinal herbal properties)].

    Science.gov (United States)

    Zhang, Lu-Li

    2010-09-01

    Liu Yue-heng, a famous doctor in Hunan province during Qing dynasty is the author of Shengcaoyaoxingfangpu (Guidebook of Chinese medicinal herbs) which systematically summed up the properties, flavors and channel tropism of the local herbal medicines and supplemented a lack knowledge of those. The book collected broadly folk and proved prescriptions and, combined with the author's clinical experiences. He collected and classified them as chapters, reflected geographical environment and folk custom culture with the distinctive regional characteristics of Huxiang. Its achievement is mainly embodied in the following aspects: it attached importance to herbs, highlighted Huxiang characteristics, the skilful use of folk and proved prescriptions and comprehensively differentiated etiology and pathogenesis, and proposed for doctors' professional ethics. PMID:21163083

  6. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats

    Institute of Scientific and Technical Information of China (English)

    Jang-Woo Shin; Myong-Min Lee; Xiao Ping Hu; Chang-Gue Son; Jin-Young Son; Se-Mi Oh; Seung-Hyun Han; Jing-Hua Wang; Jung-Hyo Cho; Chong-Kwan Cho; Hwa-Seung Yoo; Yeon-Weol Lee

    2006-01-01

    AIM: To evaluate the therapeutic effect of Chunggan extract (CGX), a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine (DMN)-induced chronic liver injury model in rats.METHODS: Liver injuries were induced in Wistar rats by injection of DMN (ip, 10 mg/mL per kg) for 3 consecutive days per week for 4 wk. The rats were administered with CGX (po, 100 or 200 mg/kg per day) or distilled water as a control daily for 4 wk starting from the 15th d of the DMN treatment. Biochemical parameters (serum albumin, bilirubin, ALP, AST and ALT), lipid peroxides,hydroxyproline, as well as histological changes in liver tissues were analyzed. In addition, gene expression of TNF-α, TGF-β, TIMP-1, TIMP-2, PDGF-β, and MMP-2, all of which are known to be associated with liver fibrosis,were analyzed using real-time PCR.RESULTS: CGX administration restored the spleen weight to normal after having been increased by DMN treatment.Biochemical analysis of the serum demonstrated that CGX significantly decreased the serum level of ALP (P< 0.05), ALT (P < 0.01), and AST (P < 0.01) that had been elevated by DMN treatment. CGX administration moderately lowered lipid peroxide production and markedly lowered hydroxyproline generation caused by DMN treatment in accordance with histopathological examination. DMN treatment induced a highly upregulated expression of TNF-α, TGF-β, TIMP-1, TIMP-2,PDGF-β, and MMP-2. Of these, the gene expression encoding PDGF-β and MMP-2 was still further enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably ameliorated by CGX administration.CONCLUSION: CGX exhibits hepatotherapeutic properties against chronic hepatocellular destruction and consequential liver fibrosis.

  7. 四个抗球虫中药复方对肉鸡球虫病疗效对比试验%Efficacy Comparative of Four Chinese Herbal Compounds on Coccidiosis in Broiler Chickens

    Institute of Scientific and Technical Information of China (English)

    郭红斌; 弓素梅; 王凤霞

    2011-01-01

    试验按照中兽医辨证论治的原则,根据鸡球虫病的特点,组成了4个中药方剂.为了比较4个中药复方对内鸡感染柔嫩艾美耳球虫(Eimeria tenella)的治疗效果,通过观察临床症状,测定存活率、相对增重率、病变值、卵囊值等,计算抗球虫指数.结果表明,方剂一的抗球虫指数最高,抗球虫效果较好.%Four Chinese herbal formula were composed according to the characteristics of chicken coccidiosis and based on the rule of syndrome differentiation and treatment of the traditional Chinese veterinary medicine. The efficacy of four Chinese herbal compounds for broiler chickens infected with Eimeria tenella were compared through observing the clinical symptoms,determining survival rate, relative growth rate, cecal lesion score and oocysts value and then calculating the anticoccidial in dex. The results showed that the anticoccidial index of Formula 1 was the highest, and its anticoccidial efficacy was better than others.

  8. Effects of Chinese herbal enema therapy combined basic treatment on BUN,SCr,UA,and IS in chronic renal failure patients

    Institute of Scientific and Technical Information of China (English)

    邹川

    2012-01-01

    Objective To assess the clearance role and safety of Chinese herbal enema therapy (CHET) in clearing enterogenic uremic toxins in chronic renal failure (CRF) patients,thus providing evidence for further optimizing the comprehensive treatment. Methods Using nonrandomized concurrent control

  9. Evaluation of acute and sub-chronic toxicities of ulcer fast and reg;: a bi-herbal formula in male Wistar albino rats

    OpenAIRE

    Kingsley C. Patrick-Iwuanyanwu; Jane A. Emerue

    2014-01-01

    The acute and sub-chronic toxicities of ulcer fast and reg; (UF) - A commercial bi-herbal formula prepared with Alstonia boonei and Xylopia aethiopica in male Wistar albino rats was evaluated. There was no mortality in rats administered 2000 mg/kg body weight (BW) of UF in an acute toxicity study. A significant (p and #8804;0.05) increase in daily consumption of feed and fluid intake in experimental rats after 28 days was recorded followed by a progressive increase in BW of rats administered ...

  10. Evaluation of Antioxidant and Antimicrobial Activities from 28 Chinese Herbal Medicines

    Directory of Open Access Journals (Sweden)

    Ho-Yang Lin

    2013-05-01

    Full Text Available Background: Many Chinese medicines have been reported to exhibit high antimicrobial and antioxidantactivities. In this study, 28 traditional Chinese herbal medicines were tested for their antioxidant and antibacterial activities.Materials and Methods: Total flavonoid content of the ethanol extracts were determined by a colorimetric method. Total phenol content was estimated as gallic acid equivalents. The antioxidant activities of the extracts were evaluated by various antioxidant assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH radical scavenging, troloxequivalent antioxidant capacity (TEAC and reducing power. In addition to the antioxidant activity, the antimicrobial assay was measured as well. Six strains of the clinical antibiotic resistant pathogens includingEscherichia coli, Staphylococcus aureus, methicine resistant Staphylococcus aureus (MRSA, ornithine resistant Staphylococcus aureus (ORSA, Pseudomonas aeruginosa, and Acinetobacter baumannii were used in the tests.Results: Among the extracts screened, Artemisia vulgaris and Sanguisorba officinalis showed the best antioxidant performance in all the tested methods.In vitro antibacterial activity, the extracts of Paeonia suffruticosa and Cinnamomum cassia displayed a broad antimicrobial spectrum and significantantimicrobial activities, with inhibition zones between 14-28 mm, minimum inhibitory concentration (MIC between 0.9-5.2 mg/mL, and minimum bactericidal concentration (MBC between 1.0-5.7 mg/mL. Conclusion: These data suggest that Artemisia vulgaris and Sanguisorba officinalis may be effective potential sources of natural antioxidants, and Paeoniasuffruticosa and Cinnamomum cassia are potent inhibitors of antibiotic resistant pathogens.

  11. Herbal medicines and nonalcoholic fatty liver disease.

    Science.gov (United States)

    Yao, Hong; Qiao, Yu-Jie; Zhao, Ya-Li; Tao, Xu-Feng; Xu, Li-Na; Yin, Lian-Hong; Qi, Yan; Peng, Jin-Yong

    2016-08-14

    Nonalcoholic fatty liver disease (NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines (including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future.

  12. Herbal medicines and nonalcoholic fatty liver disease

    Science.gov (United States)

    Yao, Hong; Qiao, Yu-Jie; Zhao, Ya-Li; Tao, Xu-Feng; Xu, Li-Na; Yin, Lian-Hong; Qi, Yan; Peng, Jin-Yong

    2016-01-01

    Nonalcoholic fatty liver disease (NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines (including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future. PMID:27570425

  13. Applicability of various estimation formulas to assess renal function in Chinese children

    Institute of Scientific and Technical Information of China (English)

    Yue Du; Ting-Ting Sun; Ling Hou; Jin-Jie Guo; Xiu-Li Wang; Yu-Bin Wu

    2015-01-01

    Background: This study was to evaluate the relative applicability of the most commonly used estimation formulas for renal glomerular filtration rate (GFR) of Chinese children with chronic kidney disease (CKD). Methods: One hundred CKD patients of less than 17 years old were divided into two groups by sex which was further categorized intofi ve subgroups based on CKD staging according to the "reference" GFR (rGFR) determined by Tc-99m-DTPA renal dynamic imaging. Four GFR markers including serum cystatin C (CysC),β2-microglobulin, creatinine, and blood urea nitrogen were measured. Results: Among all four markers, CysC best refl ected the extent of glomerular damages for CKD stage 1. The value for estimation of GFR (eGFR) was derived from five different formulas either over-estimated or under-estimated GFR as referenced to rGFR, and the extent of deviations was dependent on gender, age and CKD stage. The Counahan-Barratt formula and the Schwartz formula gave the most accurate estimations of GFR for CKD stages 1 and 2-3, respectively regardless of gender and age differences. Receiver operating characteristic analyses indicated that the Counahan-Barratt formula has the highest diagnostic accuracy. Conclusion: The Counahan-Barratt formula provides the best approximation to rGFR, thereby the highest applicability to Chinese children with CKD of different genders, ages and CKD stages.

  14. Plant Sources of Chinese Herbal Remedies: Laboratory Efficacy, Suppression of Meloidogyne javanica in Soil, and Phytotoxicity Assays

    OpenAIRE

    Zasada, I. A.; Ferris, H.; Zheng, L

    2002-01-01

    Extracts of Chinese herbal medicines from plants representing 13 families were tested for their ability to suppress plant-parasitic nematodes. Effective concentration (EC50 and EC90) levels for 18 of the extracts were determined in laboratory assays with Meloidogyne javanica juveniles and all stages of Pratylenchus vulnus. Efficacy of 17 extracts was tested against M. javanica in soil. Generally, EC50 and EC90 values determined in the laboratory were useful indicators for application rates in...

  15. Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid

    Directory of Open Access Journals (Sweden)

    Sun Andy

    2010-04-01

    Full Text Available Abstract Background Advanced cancer is a multifactorial disease that demands treatments targeting multiple cellular pathways. Chinese herbal cocktail which contains various phytochemicals may target multiple dys-regulated pathways in cancer cells and thus may provide an alternative/complementary way to treat cancers. Previously we reported that the Chinese herbal cocktail Tien-Hsien Liguid (THL can specifically induce apoptosis in various cancer cells and have immuno-modulating activity. In this study, we further evaluated the anti-metastatic, anti-angiogenic and anti-tumor activities of THL with a series of in vitro and in vivo experiments. Methods The migration and invasion of cancer cells and endothelial cells was determined by Boyden chamber transwell assays. The effect of THL on pulmonary metastasis was done by injecting CT-26 colon cancer cells intravenously to syngenic mice. The in vitro and in vivo microvessel formation was determined by the tube formation assay and the Matrigel plug assay, respectively. The in vivo anti-tumor effect of THL was determined by a human MDA-MB-231 breast cancer xenograft model. The expression of metalloproteinase (MMP-2, MMP-9, and urokinase plasminogen activator (uPA was measured by gelatin zymography. The expression of HIF-1α and the phosphorylation of ERK1/2 were determined by Western blot. Results THL inhibited the migration and invasion ability of various cancer cells in vitro, decreased the secretion of MMP-2, MMP-9, and uPA and the activity of ERK1/2 in cancer cells, and suppressed pulmonary metastasis of CT-26 cancer cells in syngenic mice. Moreover, THL inhibited the migration, invasion, and tube formation of endothelial cells in vitro, decreased the secretion of MMP-2 and uPA in endothelial cells, and suppressed neovascularization in Matrigel plugs in mice. Besides its inhibitory effect on endothelial cells, THL inhibited hypoxia-induced HIF-1α and vascular endothelial growth factor-A expression

  16. Systematic review and meta-analysis of the clinical efficacy and adverse effects of Chinese herbal decoction for the treatment of gout.

    Directory of Open Access Journals (Sweden)

    Liang Zhou

    Full Text Available BACKGROUND: In East Asia, numerous reports describe the utilization of traditional Chinese herbal decoctions to treat gout. However, the reported clinical effects vary. OBJECTIVES: In this study, we reviewed and analyzed a large number of randomized controlled clinical trials to systematically assess the clinical efficacy and adverse reactions of Chinese herbal decoctions for treating gout. METHODS: We performed a comprehensive search of databases, such as PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Chinese biomedical literature database, et al. In addition, we manually searched the relevant meeting information in the library of the Third Military Medical University. RESULTS: Finally, 17 randomized controlled trials with a sample size of 1,402 cases met the criteria and were included in the study. The results of the meta-analysis showed that when gout had progressed to the stage of acute arthritis, there was no significant difference in clinical efficacy between Chinese herbal decoctions and traditional Western medicine, as indicated based on the following parameters: serum uric acid (standardized mean difference (SMD:0.35, 95% confidence interval (CI: 0.03 to 0.67, C reactive protein (SMD: 0.25, 95% CI: -0.18 to 0.69, erythrocyte sedimentation rate (SMD: 0.21, 95% CI: -0.02 to 0.45 and overall clinical response (relative risk (RR: 1.05, 95% CI: 1.01 to 1.10. However, the Chinese herbal decoction was significantly better than traditional Western medicine in controlling adverse drug reactions (RR: 0.06, 95% CI: 0.03 to 0.13. CONCLUSIONS: Through a systematic review of the clinical efficacy and safety of Chinese herbal decoctions and traditional Western medicine for the treatment of gout, we found that Chinese herbal decoction and traditional Western medicine led to similar clinical efficacy, but the Chinese herbal decoctions were superior to Western medicine in terms of controlling adverse drug reactions.

  17. A review of potential harmful interactions between anticoagulant/antiplatelet agents and Chinese herbal medicines.

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    Hsin-Hui Tsai

    Full Text Available BACKGROUND: The risks attributed to drug-herb interactions, even when known, are often ignored or underestimated, especially for those involving anti-clotting drugs and Chinese medicines. The aim of this study was to structurally search and evaluate the existing evidence-based data associated with potential drug interactions between anticoagulant/antiplatelet drugs and Chinese herbal medicines (CHMs and evaluate the documented mechanisms, consequences, and/or severity of interactions. METHODOLOGY AND FINDINGS: Information related to anticoagulant/antiplatelet drug-CHM interactions was retrieved from eight interaction-based textbooks, four web resources and available primary biomedical literature. The primary literature searches were conducted in English and/or Chinese from January 2000 through December 2011 using the secondary databases (e.g., PubMed, Airiti Library, China Journal full-text database. The search terms included the corresponding medical subject headings and key words. Herbs or natural products not used as a single entity CHM or in Chinese Medicinal Prescriptions were excluded from further review. The corresponding mechanisms and severity ratings of interactions were retrieved using MicroMedex®, Lexicomp® and Natural Medicines Comprehensive Database®. Finally, we found 90 single entity CHMs contributed to 306 documented drug-CHM interactions. A total of 194 (63.4% interactions were verified for its evidence describing possible mechanisms and severity. Of them, 155 interactions (79.9% were attributable to pharmacodynamic interactions, and almost all were rated as moderate to severe interactions. The major consequences of these interactions were increased bleeding risks due to the additive anticoagulant or antiplatelet effects of the CHMs, specifically danshen, dong quai, ginger, ginkgo, licorice, and turmeric. CONCLUSIONS/SIGNIFICANCE: Conventional anticoagulants and antiplatelet drugs were documented to have harmful interactions

  18. Oral Chinese Herbal Medicine for Treatment of Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Zhu, Yu-Shuo; Li, Yun-Lun; Ju, Jian-Qing; Du, Feng; Zang, Yan-Ping; Wang, Xiao-Bing; Sheng, Jie

    2016-01-01

    Dilated cardiomyopathy (DCM) is one of the main causes of heart failure and could increase death, hospitalization, and rehospitalization rate. The effect of conventional medicine treatment (CMT) is limited; meanwhile, the combination of CMT and Oral Chinese Herbal Medicine (OCHM) represents exciting adjunctive therapies. In this study, we ascertained the therapeutic effect of OCHM in combination with CMT for dilated cardiomyopathy by using meta-analysis methods for controlled clinical trials. We searched studies from five databases and extracted data from these studies. We also assessed the methodological quality of the included studies. We evaluated the following outcome measures to estimate the prognosis in patients with DCM: left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), stroke volume (SV), brain natriuretic peptide (BNP), 6-minute walk test (6MWT), and overall efficacy. The result showed that OCHM combined with CMT for the improvement of therapeutic effect in DCM patients. However, the evidence remains weak due to the small sample size, high clinical heterogeneity, and poor methodological quality of the included trials. Further, large sample size and well-designed trials are needed. PMID:27630730

  19. New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

    Directory of Open Access Journals (Sweden)

    Betty Yuen Kwan Law

    2016-03-01

    Full Text Available Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as misfolded proteins or damaged organelles. Defects in autophagy are implicated in the pathogenesis of diseases including cancers, myopathy, neurodegenerations, infections and cardiovascular diseases. In the recent decade, traditional drugs with new clinical applications are not only commonly found in Western medicines, but also highlighted in Chinese herbal medicines (CHM. For instance, pharmacological studies have revealed that active components or fractions from Chaihu (Radix bupleuri, Hu Zhang (Rhizoma polygoni cuspidati, Donglingcao (Rabdosia rubesens, Hou po (Cortex magnoliae officinalis and Chuan xiong (Rhizoma chuanxiong modulate cancers, neurodegeneration and cardiovascular disease via autophagy. These findings shed light on the potential new applications and formulation of CHM decoctions via regulation of autophagy. This article reviews the roles of autophagy in the pharmacological actions of CHM and discusses their new potential clinical applications in various human diseases.

  20. Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials

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    Yan Wang

    2012-01-01

    Full Text Available Parkinson's disease (PD is a common and debilitating neurodegenerative disorder that needs long-term levodopa administration and can result in progressive deterioration of body functions, daily activities and participation. The objective of this meta-analysis evaluates the clinical efficacy and safety of Chinese herbal medicine (CHM as an adjunct therapy for PD patients. Methodological issues include a systematic literature search between 1950 and April 2011 to identify randomized trials involving CHM adjuvant therapy versus western conventional treatment. The outcome measures assessed were the reduction in scores of Unified Parkinson's Disease Rating Scale (UPDRS and adverse effects. 19 trials involving 1371 participants were included in the meta-analysis. As compared to western conventional treatment, CHM adjuvant therapy resulted in greater improvement in UPDRS I, II, III, IV scores, and UPDRS I–IV total scores (P<0.001. Adverse effects were reported in 9 studies. The side effects in CHM adjuvant therapy group were generally less than or lighter than the conventional treatment group. In conclusion, CHM adjuvant therapy may potentially alleviate symptoms of PD and generally appeared to be safe and well tolerated by PD patients. However, well-designed, randomized, placebo-controlled clinical trials are still needed due to the generally low methodological quality of the included studies.

  1. [Application prospect and expectation of fungistatic agents of plants in preservation of Chinese herbal medicines].

    Science.gov (United States)

    Li, Yan-jun; Kong, Wei-jun; Hu, Yi-chen; Zhao, Lian-hua; Yang, Shi-hai; Yang, Mei-hua

    2015-10-01

    During the process of growth, harvesting, transportation, processing and storage, Chinese herbal medicines (CHMs) can be easily contaminated by fungi and their metabolites like mycotoxins, which not only express negative effects on the quality and safety of CHMs and their processed products, but also pose great threats to human health. Now, some chemical synthetic fungicides have been frequently used to control the growth of fungi and accumulation of mycotoxins in the preservation of CHMs. However, the concentration and type of chemical fungicides allowed for postharvest application are restricted due to the disadvantages of their high residual toxicity, long degradation period and pollution to the environment and so on. Therefore, it is critical to research and develop some highly effective, safe and non-toxic, natural, environment-friendly fungistatic agents from plants to prevent CHMs from being contaminated by fungi and mycotoxins. The paper reviews mycotoxins and their harmfulness, the effective compounds of fungistatic plants as well as the antifungal mechanism to provide scientific evidences for developing novel and effective fungistatic agents plants. Then, the application prospect of fungistatic agents from plants in the preservation of CHMs was discussed.

  2. Oral Chinese Herbal Medicine for Treatment of Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    Zhu, Yu-Shuo; Ju, Jian-Qing; Du, Feng; Zang, Yan-Ping; Wang, Xiao-Bing; Sheng, Jie

    2016-01-01

    Dilated cardiomyopathy (DCM) is one of the main causes of heart failure and could increase death, hospitalization, and rehospitalization rate. The effect of conventional medicine treatment (CMT) is limited; meanwhile, the combination of CMT and Oral Chinese Herbal Medicine (OCHM) represents exciting adjunctive therapies. In this study, we ascertained the therapeutic effect of OCHM in combination with CMT for dilated cardiomyopathy by using meta-analysis methods for controlled clinical trials. We searched studies from five databases and extracted data from these studies. We also assessed the methodological quality of the included studies. We evaluated the following outcome measures to estimate the prognosis in patients with DCM: left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), stroke volume (SV), brain natriuretic peptide (BNP), 6-minute walk test (6MWT), and overall efficacy. The result showed that OCHM combined with CMT for the improvement of therapeutic effect in DCM patients. However, the evidence remains weak due to the small sample size, high clinical heterogeneity, and poor methodological quality of the included trials. Further, large sample size and well-designed trials are needed.

  3. The Ethics of Traditional Chinese and Western Herbal Medicine Research: Views of Researchers and Human Ethics Committees in Australia

    Directory of Open Access Journals (Sweden)

    Caroline A. Smith

    2011-01-01

    Full Text Available Despite the growth of traditional Chinese medicine (TCM and western herbal medicine (WHM research in Australia, little is known about how ethics committees (HRECs assess the ethics of TCM or WHM research. The objectives of this study were to examine the experiences of TCM and WHM researchers and HRECs with the evaluation of ethics applications. Two cross-sectional surveys were undertaken of HRECs and TCM and WHM researchers in Australia. Anonymous self-completion questionnaires were administered to 224 HRECs and 117 researchers. A response confirming involvement in TCM or WHM research applications was received from 20 HRECs and 42 researchers. The most frequent ethical issues identified by HRECs related to herbal products including information gaps relating to mode of action of herbal medicines and safety when combining herbal ingredients. Researchers concurred that they were frequently requested to provide additional information on multiple aspects including safety relating to the side effects of herbs and herb-drug interactions. Overall adherence with the principles of ethical conduct was high among TCM and WHM researchers although our study did identify the need for additional information regarding assessment of risk and risk management.

  4. Biorefinery engineering for Chinese herbal medicines: a review%中草药生物质炼制工程

    Institute of Scientific and Technical Information of China (English)

    陈洪章; 隋文杰

    2014-01-01

    The resource limitation,ineffective utilization and severe waste generated during processing restrict the sustainable development of the Chinese herbal medicine industry.The main reasons lie in insufficient utilization of medicinal components as well as few and outdated technologies.Integration and optimization of serial technologies including pretreatment,extraction,conversion and waste treatment are the keys to solve these issues.In this article,the updated research progress and technology development of biorefinery engineering for herbal medicines are reviewed.Guided by multi-products oriental fractionation refining,Chinese herbal medicine refinery technical system is constructed relied on advanced refinery technology platforms.%目前我国中药产业面临资源紧张、药材利用率低、加工过程浪费严重等问题,究其原因主要是单一药效成分利用、加工转化技术落后所致.针对上述问题,从生物质炼制角度,综述了实现中草药资源高效利用的原料预处理、提取、转化及残渣后处理等4个关键单元操作中主要技术的研究进展,并指出中草药生物质炼制工程发展趋势与前景.

  5. Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines

    Directory of Open Access Journals (Sweden)

    Lin Ge

    2010-07-01

    Full Text Available Abstract Multi-drug resistance (MDR of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.

  6. Quality control of Chinese herbal tonic wine by high performance liquid chromatography fingerprint

    NARCIS (Netherlands)

    Wei, X.J.; Zhang, H.; Wang, W.F.; Li, B.; Yang Zhu, Yang

    2007-01-01

    Herbal tonic wines are alcoholic drinks in which medicinal herbs are soaked and extracted. These drinks are considered having various health functions. However, the quality of herbal products is largely influenced by the origin and harvest season of the herbs. Due to its high commercial value, count

  7. Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map.

    Directory of Open Access Journals (Sweden)

    Zhining Wen

    Full Text Available To pursue a systematic approach to discovery of mechanisms of action of traditional Chinese medicine (TCM, we used microarrays, bioinformatics and the "Connectivity Map" (CMAP to examine TCM-induced changes in gene expression. We demonstrated that this approach can be used to elucidate new molecular targets using a model TCM herbal formula Si-Wu-Tang (SWT which is widely used for women's health. The human breast cancer MCF-7 cells treated with 0.1 µM estradiol or 2.56 mg/ml of SWT showed dramatic gene expression changes, while no significant change was detected for ferulic acid, a known bioactive compound of SWT. Pathway analysis using differentially expressed genes related to the treatment effect identified that expression of genes in the nuclear factor erythroid 2-related factor 2 (Nrf2 cytoprotective pathway was most significantly affected by SWT, but not by estradiol or ferulic acid. The Nrf2-regulated genes HMOX1, GCLC, GCLM, SLC7A11 and NQO1 were upregulated by SWT in a dose-dependent manner, which was validated by real-time RT-PCR. Consistently, treatment with SWT and its four herbal ingredients resulted in an increased antioxidant response element (ARE-luciferase reporter activity in MCF-7 and HEK293 cells. Furthermore, the gene expression profile of differentially expressed genes related to SWT treatment was used to compare with those of 1,309 compounds in the CMAP database. The CMAP profiles of estradiol-treated MCF-7 cells showed an excellent match with SWT treatment, consistent with SWT's widely claimed use for women's diseases and indicating a phytoestrogenic effect. The CMAP profiles of chemopreventive agents withaferin A and resveratrol also showed high similarity to the profiles of SWT. This study identified SWT as an Nrf2 activator and phytoestrogen, suggesting its use as a nontoxic chemopreventive agent, and demonstrated the feasibility of combining microarray gene expression profiling with CMAP mining to discover mechanisms

  8. Pharmacokinetics of Two Ingredients of the Compound Chinese Herbal Medicine Transdermal Preparation in Cows

    Institute of Scientific and Technical Information of China (English)

    WANG Gui-xia; LI Rui; ZHANG Xiu-ying

    2009-01-01

    The topical administration of the compound Chinese herbal medicine transdermal preparation has been widely used in treating the mastitis of cows.In order to understand the metabolic process,four cows suffering from clinical mastitis were selected for the pharmacokinetie study.The transdermal preparation was applied to the diseased part of breast.Then the plasma and milk samples were collected respectively at 0,0.5,1,2,4,6,8,10,12,24,and 36 h.The concentrations of baicalin and phillyrin in plasma and milk were determined by HPLC and the data of time-concentrations were analyzed by the pharmacokinetic software.The results showed that two ingredients in the plasma were not detectable,but they in the milk had linear relationship with the time.The peak concentration of baicalin [(2.84±0.15) μg mL-1]appeared at (4.93±0.35) h,AUC0-LOQ was(27.32±7.91) mg L-1 h-1,and the mean retention time was (28.31±0.49) h.The peak concentration of phillyrin [(0.49±0.41) μg mL-1]achieved at (3.68 4±3.14) h,AUC0-LOQ was (4.10±0.31) mg L-1 h-1,and the mean retention time was (14.52±0.02) h.These suggested that two ingredients had slow absorbing speed and high absorbing degree.They could not be eliminated in a short time,thus exerted the topical curative effect.

  9. Twelve Cases of Malignant Hematopathy Treated by Combined Therapy of Hematopoietic Stem Cell Transplantation andChinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    虞荣喜; 周郁鸿; 朱宁希; 沈建平; 胡致平; 罗秀素; 林圣云; 沈一平; 陈均法; 孙洁

    2002-01-01

    Objective:To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese herbal medicine in treating malignant hematopathy.Methods: Allo-bone marrow transplantation (allo-BMT) or allo-peripheral blood stem cell transplantation (allo-PBSCT), with conditioning regimen of 60  Co total body irradiation + Cyclophosphamide (TBI+Cy) or busulfan + cyclophosphamide (Bu+Cy), was used to treat 4 cases of chronic granu locytic leukemia (CGL, 3 of chronic phase and 1 of accelerating phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT, with conditioning regimen of my leran + cytosino arabinoside +cyclophosphamide (MAC) or MAC+VP16, was used to tr eat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR 1 and 2 of CR 2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. Results: All patients were successfully engrafted. Within the median follow-up period of 18 (4-70) months, 1 patient (8.3%) died a transplantation-related death, 3 ( 25.0% ) relapsed and 8 (66.7%) survived free of original disease. Conclusion: Auto-BMT or auto-PBSCT in CR 1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marow donor; allo-BMT or allo-PBSCT in chronic stage could result in long-term disease-free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain rol e in promoting recovery of hematopoietic function.

  10. Effect of Chinese Herbal Fumigation Combined with Tuina on Vertigo and Concentrations of Endothelin and Calcitonin Gene-related Peptide in Patients with Vertebral Artery Cervical Spondylosis

    Institute of Scientific and Technical Information of China (English)

    Zhao Cheng-fei; Liu Xiao-an; Ding Yun

    2014-01-01

    Objective:To observe the effect of Chinese herbal fumigation combined with three-step tuina manipulation on concentration of endothelin (ET) and calcitonin gene-related peptide (CGRP) and vertigo in patients with vertebral artery cervical spondylosis (VACS). Methods:A total of 120 eligible cases were randomly allocated into an observation group and a control group, 60 in each group. Cases in the observation group were treated with Chinese herbal fumigation combined with three-step tuina manipulation, whereas cases in the control group were treated with oral Flunarizine Hydrochloride Capsules. Results: After treatment, vertigo in both groups was alleviated; there were intra-group significant differences in ET decrease and CGRP increase (P Conclusion: Chinese herbal fumigation combined with three-step tuina manipulation can regulate the levels of ET and CGRP and improve vertigo in patients with VACS. Its therapeutic efficacy is superior to oral Flunarizine Hydrochloride Capsules.

  11. Salmonella typhimurium A1-R tumor targeting in immunocompetent mice is enhanced by a traditional Chinese medicine herbal mixture.

    Science.gov (United States)

    Zhang, Yong; Zhang, Nan; Su, Shibing; Hoffman, Robert M; Zhao, Ming

    2013-05-01

    We have developed a bacterial cancer therapy strategy using the genetically-engineered strain Salmonella typhimurium A1-R (A1-R). A1-R is auxotrophic for leu and arg which attenuates bacterial growth in normal tissue but allows high tumor virulence. A1-R is effective against metastatic human and murine cancer cell lines in clinically-relevant nude-mouse models. However, A1-R treatment of tumors in immunocompetent mouse models with high doses is limited by toxicity. The current study evaluated a traditional Chinese medicine (TCM) herbal mixture in combination with A1-R therapy in a syngeneic metastatic immunocompetent mouse model of highly aggressive lung cancer. In a model of Lewis lung carcinoma, the combination of a TCM herbal mixture and S. typhimurium A1-R enabled bacteria to be safely administered at the large dose of 2 × 10(7) colony forming units once a week i.v. with increased treatment efficacy and reduced toxicity compared to monotherapy with A1-R. The herbal mixture prevented body weight loss, spleen weight gain and liver infection by A1-R, as well as hemorrhagic lesions on the skin, liver, and spleen, all observed with A1-R monotherapy. The results of the present study suggest that the combination of A1-R and TCM has important potential for therapy of highly aggressive types of cancer, including those which are resistant to standard therapy.

  12. The In Vitro and In Vivo Wound Healing Properties of the Chinese Herbal Medicine “Jinchuang Ointment”

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    Tsung-Jung Ho

    2016-01-01

    Full Text Available “Jinchuang ointment” is a traditional Chinese herbal medicine complex for treatment of incised wounds. For more than ten years, it has been used at China Medical University Hospital (Taichung, Taiwan for the treatment of diabetic foot infections and decubitus ulcers. Three different cases are presented in this study. “Jinchuang” ointment is a mixture of natural product complexes from nine different components, making it difficult to analyze its exact chemical compositions. To further characterize the herbal ingredients used in this study, the contents of reference standards present in a subset of the ointment ingredients (dragon’s blood, catechu, frankincense, and myrrh were determined by HPLC. Two in vitro cell based assay platforms, wound healing and tube formation, were used to examine the biological activity of this medicine. Our results show that this herbal medicine possesses strong activities including stimulation of angiogenesis, cell proliferation, and cell migration, which provide the scientific basis for its clinically observed curative effects on nonhealing diabetic wounds.

  13. Chinese Herbal Medicine to explore common adulteration and identification methods%中药饮片的常见掺伪与鉴别方法的探讨

    Institute of Scientific and Technical Information of China (English)

    王桂芝; 王小娟

    2014-01-01

    目的:对几种常见中药饮片掺伪现象进行鉴别。方法:对中药饮片的性状理化进行鉴别。结果:通过对几种常见掺伪现象总结,供同行借鉴参考。%The purpose of several common phenomenon adulteration of Chinese Herbal Medicine for identification. Methods: Physical and Chemical Characters of Chinese Herbal Medicine for identification. Results: By several common phenomenon adulteration summary for peer learning reference.

  14. Involvement of the Cerebral Monoamine Neurotransmitters System in Antidepressant-Like Effects of a Chinese Herbal Decoction, Baihe Dihuang Tang, in Mice Model

    Directory of Open Access Journals (Sweden)

    Meng-Li Chen

    2012-01-01

    Full Text Available Baihe Dihuang Tang (BDT is a renowned Chinese herbal formula which is commonly used for treating patients with mental instability, absentmindedness, insomnia, deficient dysphoria, and other psychological diseases. These major symptoms closely associated with the depressive disorders. BDT was widely popular use for treating emotion-thought disorders for many years in China. In the present study, the antidepressant-like effect of BDT in mice was investigated by using the forced swim test (FST and the tail suspension test (TST. The underlying mechanism was explored by determining the effect of BDT on the level of cerebral monoamine neurotransmitters. BDT (9 and 18 g/kg, p.o. for 14 days administration significantly reduced the immobility time in both the FST and the TST without changing locomotion in the open field-test (OFT. Moreover, BDT treatment at the dose of 18 g/kg inhibited reserpine-induced ptosis. Meanwhile, BDT enhanced 5-HT and NA levels in mouse cerebrum as well as decreased the ratio of 5-HT compared to its metabolite, 5-HIAA, (turnover, 5-HIAA/5-HT after TST. The results demonstrated that the antidepressant-like effect of BDT is mediated, at least partially, via the central monoaminergic neurotransmitter system.

  15. 中草药抗白念珠菌作用研究进展%Research progress of Chinese herbal medicine against Candida albicans

    Institute of Scientific and Technical Information of China (English)

    李姝毅; 夏志宽; 杨蓉娅

    2013-01-01

    Candida albicans is one of the most common human fungal pathogen,which can cause a variety of superficial and deep mycoses,and often become resistant to commonly used antifungal agents.So looking for broad-spectrum,high efficiency,low toxicity anti-Candida drugs has became a hot research.Extremely rich resources of Chinese herbal medicine have certain advantages of the prevention and treatment of Candida infections.To study the role of Chinese herbal medicine against Candida albicans,articles summarize the three aspects:herbal mechanism of action against Candida albicans and its active ingredient,single herb and compound herbal preparations against Candida albicans,synergistic effect of compound traditional Chinese medicine and western medicine against Candida albicans.The Chinese herbal medicine against Candida albicans clinical and experimental studies in recent years were reviewed.The article further confirmed the role of herbal anti-Candida albicans and showed the broad application prospects of herbal antifungal aspects.%白念珠菌,是人类最常见的真菌病原体,可引起各种浅表及深部真菌病,对常用抗真菌药物易产生耐药.文章就近年来有关中草药抗白念珠菌的相关临床及实验研究进行综述,主要从中草药抗白念珠菌的作用机制及其活性成分、单味及复方中草药制剂抗白念珠菌作用、中西药协同抗白念珠菌作用几个方面进行阐述.

  16. 对目前中药材价格上涨因素的一些分析%The analysis of the current Chinese herbal medicines prices factors

    Institute of Scientific and Technical Information of China (English)

    印敏

    2013-01-01

    Objective To use to predict the moving average method, in order to understand the Chinese herbal medicine prices trend, analysis of Chinese herbal medicines prices faced by various factors. Methods Moving average method to forecast the years can reflect the balance of supply and demand in the market, and consumer accumulation relationship of Chinese herbal medicines and proprietary Chinese medicine retail price index uses. Results The Chinese herbal medicines prices trend existed for a long time. Conclusion Chinese herbal medicine prices face Various factors and rising pressure. And through the analysis of these factors, promote the perfection of regulating supervision mechanism of the traditional Chinese medicine production and prices.%目的:运用移动平均法进行预测,以了解中药材价格的趋势,分析中药材价格上涨面临的各种因素。方法对这几年能反映市场供需的平衡、消费与积累关系的中药材及中成药零售价格指数部分运用移动平均法预测。结果中药材价格上涨趋势存在。结论中药材价格面临各种因素,上涨压力明显。并通过对这些因素的分析,促进完善中药生产和价格调节监督机制。

  17. Evaluating the Bone Tissue Regeneration Capability of the Chinese Herbal Decoction Danggui Buxue Tang from a Molecular Biology Perspective

    Directory of Open Access Journals (Sweden)

    Wen-Ling Wang

    2014-01-01

    Full Text Available Large bone defects are a considerable challenge to reconstructive surgeons. Numerous traditional Chinese herbal medicines have been used to repair and regenerate bone tissue. This study investigated the bone regeneration potential of Danggui Buxue Tang (DBT, a Chinese herbal decoction prepared from Radix Astragali (RA and Radix Angelicae Sinensis (RAS, from a molecular biology perspective. The optimal ratio of RA and RAS used in DBT for osteoblast culture was obtained by colorimetric and alkaline phosphatase (ALP activity assays. Moreover, the optimal concentration of DBT for bone cell culture was also determined by colorimetric, ALP activity, nodule formation, Western blotting, wound-healing, and tartrate-resistant acid phosphatase activity assays. Consequently, the most appropriate weight ratio of RA to RAS for the proliferation and differentiation of osteoblasts was 5 : 1. Moreover, the most effective concentration of DBT was 1,000 μg/mL, which significantly increased the number of osteoblasts, intracellular ALP levels, and nodule numbers, while inhibiting osteoclast activity. Additionally, 1,000 μg/mL of DBT was able to stimulate p-ERK and p-JNK signal pathway. Therefore, DBT is highly promising for use in accelerating fracture healing in the middle or late healing periods.

  18. Enhancement of the Immune Response to Rabbit Hemorrhagic Disease Vaccine in Young Rabbits by Advanced Vaccination and Chinese Herbal Adjuvants

    Institute of Scientific and Technical Information of China (English)

    YANG Long-sheng; XUE Jia-bin; HU Yuan-liang; WANG Fang; WANG De-yun; XU Wei-zhong

    2008-01-01

    Experiments were conducted to determine the effects of advanced vaccination and Chinese herbal adjuvants (CHA), containing astragalus polysaccharides (APS) and ginsenosides (GS) on the immune response to rabbit hemorrhagic disease (RHD) vaccine in young rabbits. In experiment 1, 5 New Zealand rabbits of each group at 30, 35, 40, or 45 days of age were injected with 2 mL of inactivated RHD vaccine, respectively. The dynamic changes of antibody liters were tested by the hemagglutination inhibition (HI) method. In experiment 2, 30 New Zealand rabbits at 35 days of age were randomly assigned to 5 treatment groups, representing inoculation with 3 mL of non-adjuvant RHD vaccine, CHA-RHD vaccine, CHA-HA vaccine (half dose antigen), aluminium adjuvant-RHD vaccine, and PBS, respectively. The dynamic changes of peripheral lymphocyte proliferation and serum antibody liters were tested by the MTT method and the HI method. The results showed that the titer of maternal HI antibody in the 35-day-old rabbits was lower than the protective level of 3 log2, while on days 7 to 49 after the vaccination, the antibody tilers were higher than 3 log2. The CHA promoted me lymphocyte proliferation and enhanced the serum antibody liter (P<0.05). These findings from the two experiments suggested that advanced vaccination and Chinese herbal adjuvants significantly enhanced the immune response lo vaccine againsl RHD, and effectively protected the young rabbils againsl RHD challenge.

  19. Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Eric S.J., E-mail: eric.sj.harris@gmail.com [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Cao, Shugeng [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Littlefield, Bruce A. [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Craycroft, Jane A.; Scholten, Robert [Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Kaptchuk, Ted [Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States); Fu, Yanling [International Cooperation Center, Beijing University of Chinese Medicine, 11 Bai San Huan Dong Lu, Chao Yang District, Beijing 100029 (China); Wang, Wenquan; Liu, Yong [School of Chinese Pharmacy, Beijing University of Chinese Medicine, No. 6 Wangjing Zhong Huan Nan Lu, Chaoyang District, Beijing 100102 (China); Chen, Hubiao; Zhao, Zhongzhen [School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong Special Administrative Region (China); Clardy, Jon [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Woolf, Alan D. [Children' s Hospital Boston, 300 Longwood Avenue and Department of Pediatrics, Harvard Medical School, Boston, MA 02118 (United States); and others

    2011-09-15

    Heavy metal and pesticide contamination has previously been reported in Chinese Herbal Medicines (CHMs), in some cases at potentially toxic levels. This study was conducted to determine general patterns and toxicological significance of heavy metal and pesticide contamination in a broad sample of raw CHMs. Three-hundred-thirty-four samples representing 126 species of CHMs were collected throughout China and examined for arsenic, cadmium, chromium, lead, and mercury. Of the total, 294 samples representing 112 species were also tested for 162 pesticides. At least 1 metal was detected in all 334 samples (100%) and 115 samples (34%) had detectable levels of all metals. Forty-two different pesticides were detected in 108 samples (36.7%), with 1 to 9 pesticides per sample. Contaminant levels were compared to toxicological reference values in the context of different exposure scenarios. According to a likely scenario of CHM consumption, only 3 samples (1%) with heavy metals and 14 samples (5%) with pesticides were found with concentrations that could contribute to elevated background levels of contaminant exposure. According to the most conservative scenario of CHM consumption, 231 samples (69%) with heavy metals and 81 samples (28%) with pesticides had contaminants that could contribute to elevated levels of exposure. Wild collected plants had higher contaminant levels than cultivated samples. Cadmium, chromium, lead, and chlorpyrifos contamination showed weak correlations with geographic location. Based on our assumptions of the likely mode of consumption of raw CHMs, the vast majority (95%) of the 334 samples in this study contained levels of heavy metals or pesticides that would be of negligible concern. However, given the number of samples with detectable contaminants and the range between the more likely and more conservative scenarios of contaminant exposure, more research and monitoring of heavy metals (especially cadmium and chromium) and pesticide residues

  20. Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines

    International Nuclear Information System (INIS)

    Heavy metal and pesticide contamination has previously been reported in Chinese Herbal Medicines (CHMs), in some cases at potentially toxic levels. This study was conducted to determine general patterns and toxicological significance of heavy metal and pesticide contamination in a broad sample of raw CHMs. Three-hundred-thirty-four samples representing 126 species of CHMs were collected throughout China and examined for arsenic, cadmium, chromium, lead, and mercury. Of the total, 294 samples representing 112 species were also tested for 162 pesticides. At least 1 metal was detected in all 334 samples (100%) and 115 samples (34%) had detectable levels of all metals. Forty-two different pesticides were detected in 108 samples (36.7%), with 1 to 9 pesticides per sample. Contaminant levels were compared to toxicological reference values in the context of different exposure scenarios. According to a likely scenario of CHM consumption, only 3 samples (1%) with heavy metals and 14 samples (5%) with pesticides were found with concentrations that could contribute to elevated background levels of contaminant exposure. According to the most conservative scenario of CHM consumption, 231 samples (69%) with heavy metals and 81 samples (28%) with pesticides had contaminants that could contribute to elevated levels of exposure. Wild collected plants had higher contaminant levels than cultivated samples. Cadmium, chromium, lead, and chlorpyrifos contamination showed weak correlations with geographic location. Based on our assumptions of the likely mode of consumption of raw CHMs, the vast majority (95%) of the 334 samples in this study contained levels of heavy metals or pesticides that would be of negligible concern. However, given the number of samples with detectable contaminants and the range between the more likely and more conservative scenarios of contaminant exposure, more research and monitoring of heavy metals (especially cadmium and chromium) and pesticide residues

  1. Oral Chinese herbal medicine combined with pharmacotherapy for stable COPD: a systematic review of effect on BODE index and six minute walk test.

    Directory of Open Access Journals (Sweden)

    Xiankun Chen

    Full Text Available This systematic review evaluated the effects of Chinese herbal medicine (CHM plus routine pharmacotherapy (RP on the objective outcome measures BODE index, 6-minute walk test (6MWT, and 6-minute walk distance (6MWD in individuals with stable chronic obstructive pulmonary disease (COPD. Searches were conducted of six English and Chinese databases (PubMed, EMBASE, CENTRAL, CINAHL, CNKI and CQVIP from their inceptions until 18th November 2013 for randomized controlled trials involving oral administration of CHM plus RP compared to the same RP, with BODE Index and/or 6MWT/D as outcomes. Twenty-five studies were identified. BODE Index was used in nine studies and 6MWT/D was used in 22 studies. Methodological quality was assessed using the Cochrane Risk of Bias tool. Weaknesses were identified in most studies. Six studies were judged as 'low' risk of bias for randomisation sequence generation. Twenty-two studies involving 1,834 participants were included in the meta-analyses. The main meta-analysis results showed relative benefits for BODE Index in nine studies (mean difference [MD] -0.71, 95% confidence interval [CI] -0.94, -0.47 and 6MWT/D in 17 studies (MD 54.61 meters, 95%CI 33.30, 75.92 in favour of the CHM plus RP groups. The principal plants used were Astragalus membranaceus, Panax ginseng and Cordyceps sinensis. A. membranaceus was used in combination with other herbs in 18 formulae in 16 studies. Detailed sub-group and sensitivity analyses were conducted. Clinically meaningful benefits for BODE Index and 6MWT were found in multiple studies. These therapeutic effects were promising but need to be interpreted with caution due to variations in the CHMs and RPs used and methodological weakness in the studies. These issues should be addressed in future trials.

  2. A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

    Directory of Open Access Journals (Sweden)

    Tung-Ting Sham

    2014-01-01

    Full Text Available Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD. For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

  3. CLINICAL ANALYSIS ON THE TREATMENT OF FACIAL PARALYSIS BY ACUPUNCTURE, MOXIBUSTION PLUS CHINESE HERBAL MEDICINES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-sha; SHEN Wei-hong

    2005-01-01

    Objective:To observe the therapeutic effect of the integrated acupuncture-moxibustion and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupuncture-moxibustion and herbal therapies. For facial palsy patients with wind-phlegm blocking meridian-collaterals and wind-stirring due to yin deficiency types in the acute stage, Modified respectively; and for those in convalescent stage and sequela stage, Replenishing Blood) + Qian Zheng San (Powder for Treating Wry-mouth) and Recuperation) were employed. Results: After the treatment, the curative rate of the 68 cases accounted for 90% of the total cases, the remarkably effective 6%, the improved 3% and the poor 1% respectively. Conclusion: The therapeutic effectiveness of the integrated treatment of acupuncture-moxibustion and herbal therapies for facial paralysis is certain.

  4. Suppressive effects of QFGJS, a preparation from an anti-arthritic herbal formula, on rat experimental adjuvant-induced arthritis

    International Nuclear Information System (INIS)

    To analyze the anti-arthritic effects of QFGJS (a pharmaceutical preparation from herbs) on rheumatoid arthritis, adjuvant-induced arthritis (AIA) was established in male SD rats, and two administration protocols, i.e., oral treatment with different doses of QFGJS on the day of arthritis induction or on the day when visible clinical signs of arthritis occurred, were initiated and continued until day 30. Treatments with QFGJS using both administration protocols significantly suppressed the incidence and severity of arthritis in a dose-dependent manner, showing dramatic reduction of paw swelling and ESR throughout the disease progression of AIA. Radiological and histopathological examinations showed markedly decreased tissue and bone destruction of ankle joints in the QFGJS-treated rats. The serum levels of TNF-α, IL-1β, and IL-6 were significantly decreased in the QFGJS-treated rats. QFGJS demonstrates pronounced anti-arthritic effects on AIA, indicating that this herbal preparation would be a potent candidate as a novel botanical drug for further investigation

  5. Clinical effects of a standardized Chinese herbal remedy, Qili Qiangxin, as an adjuvant treatment in heart failure: systematic review and meta-analysis

    OpenAIRE

    Sun, Jin; Zhang, Kang; Xiong, Wen-jing; Yang, Guo-Yan; Zhang, Yun-Jiao; Wang, Cong-Cong; Lai, Lily; Han, Mei; Ren, Jun; Lewith, George; Liu, Jian-ping

    2016-01-01

    Background Qili Qiangxin capsule is a standardized Chinese herbal treatment that is commonly used in China for heart failure (HF) alongside conventional medical care. In 2014, Chinese guidelines for the treatment of chronic HF highlighted Qili Qiangxin capsules as a potentially effective medicine. However, there is at present no high quality review to evaluate the effects and safety of Qili Qiangxin for patients with HF. Methods We conducted a systematic review and meta-analysis and followed ...

  6. Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

    OpenAIRE

    Xiuhui Li; Xi Zhang; Jianbo Ding; Yi Xu; Dan Wei; Yimei Tian; Wei Chen; Jihan Huang; Tao Wen; Shuangjie Li

    2014-01-01

    Background. This study was made to evaluate the efficacy of Chinese herbal medicines, Reduning injection, and a traditional Chinese medicine (TCM) granule, in patients with severe hand, foot, and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial. Methods. 355 severe HFMD patients were randomly assigned to receive conventional therapy alone, Reduning injection plus conventional therapy, or TCM enema plus conventional therapy for 7–10 days. Results. There was no...

  7. Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.

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    Wei Chen

    Full Text Available BACKGROUND: Chinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is no critically appraised evidence such as systematic reviews or meta-analyses on potential benefits and harms of medicinal herbs for H1N1 influenza to justify their clinical use and their recommendation. METHODS AND FINDINGS: CENTRAL, MEDLINE, EMBASE, CBM, CNKI, VIP, China Important Conference Papers Database, China Dissertation Database, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs of Chinese herbs for H1N1 influenza till 31 August, 2011. A total of 26 RCTs were identified and reviewed. Most of the RCTs were of high risk of bias with flawed study design and poor methodological quality. The combination of several Chinese herbal medicines with or without oseltamivir demonstrated positive effect on fever resolution, relief of symptoms, and global effectiveness rate compared to oseltamivir alone. However, only one herbal medicine showed positive effect on viral shedding. Most of the trials did not report adverse events, and the safety of herbal medicines is still uncertain. CONCLUSIONS: Some Chinese herbal medicines demonstrated potential positive effect for 2009 type A H1N1 influenza; however, due to the lack of placebo controlled trial and lack of repeated test of the intervention, we could not draw confirmative conclusions on the beneficial effect of Chinese herbs for H1N1 influenza. More rigorous trials are warranted to support their clinical use.

  8. Application of the HACCP system in the Chinese herbal health tonic industry%HACCP在中草药保健口服液中的应用

    Institute of Scientific and Technical Information of China (English)

    王涛; 陆智; 李德灵

    2012-01-01

    The application of the hazard analysis and critical control point system(HACCP) in the Chinese herbal health tonic industry were described in detail in this paper,taking the Infinitus Health Tonic as example,in order to promote the application of HACCP system in the Chinese herbal health tonic industry and improve the normalization and the standardization of the Chinese herbal health tonic products as well as the management level of the Chinese herbal health tonic industry.%本文以无限极增健口服液为例,详细地介绍了HACCP体系在中草药保健口服液行业的应用,旨在促进HACCP体系在中草药保健口服液中的进一步推广,从而提高中草药保健口服液的规范化、标准化生产经营水平。

  9. Twenty-eight Cases of Diabetic Foot Ulcer and Gangrene Treated with the Chinese Herbal Medicine Combined with Injection of Ahylsantinfarctase

    Institute of Scientific and Technical Information of China (English)

    王凡

    2002-01-01

    @@ Since 1995, the Chinese herbal medicine for supplementing qi and activating blood circulation combined with injection of ahylsantinfarctase into the femoral artery has been used in 28 cases of diabetes complicated with gangrene and ulcer of the foot, with quite good therapeutic effects as reported in the following.

  10. Clinical Study on Chinese Herbal Enema in Adjuvant Treatment of Uremia%中药灌肠辅助治疗尿毒症的临床研究

    Institute of Scientific and Technical Information of China (English)

    吕丽萍

    2015-01-01

    Objective: To investigate effect of Chinese herbal enema with hemodialysis in adjuvant treatment of uremia.Method: Patients (76 cases) with uraemia in telophase were randomly divided into two groups: Chinese herbal enema with hemodialysis group (n=38), and conventional hemodialysis group (n=38). Chinese herbal enema with hemodialysis group reduced hemodialysis times and prolonged hemodialysis interval for 4 weeks to observe the changes of every clinical parameters.Result: There was no significant difference between the two groups (P>0.05). Chinese herbal enema with hemodialysis group was better than conventional hemodialysis group in protecting residual renal function (P0.05);辅助治疗组较透析对照组透析时间间隔明显延长,治疗后对残余肾功能保护作用明显优于对照组,比较差异有统计学意义(P<0.05)。结论:中药灌肠辅助治疗配合血液透析在不影响透析效果的前提下,较单纯的血液透析明显改善了患者生活质量,显著延长透析时间间隔,并可以适度延缓残余肾功能恶化的进展。

  11. Effects of Chinese herbal monomers on oxidative phosphorylation and membrane potential in cerebral mitochondria isolated from hypoxia-exposed rats in vitro

    Institute of Scientific and Technical Information of China (English)

    Weihua Yan; Junze Liu

    2012-01-01

    Mitochondrial dysfunction is the key pathogenic mechanism of cerebral injury induced by high-altitude hypoxia. Some Chinese herbal monomers may exert anti-hypoxic effects through enhancing the efficiency of oxidative phosphorylation. In this study, effects of 10 kinds of Chinese herbal monomers on mitochondrial respiration and membrane potential of cerebral mitochondria isolated from hypoxia-exposed rats in vitro were investigated to screen anti-hypoxic drugs. Rats were exposed to a low-pressure environment of 405.35 mm Hg (54.04 kPa) for 3 days to establish high-altitude hypoxic models. Cerebral mitochondria were isolated and treated with different concentrations of Chinese herbal monomers (sinomenine, silymarin, glycyrrhizic acid, baicalin, quercetin, ginkgolide B, saffron, piperine, ginsenoside Rg1 and oxymatrine) for 5 minutes in vitro. Mitochondrial oxygen consumption and membrane potential were measured using a Clark oxygen electrode and the rhodamine 123 fluorescence analysis method, respectively. Hypoxic exposure significantly decreased the state 3 respiratory rate, respiratory control rate and mitochondrial membrane potential, and significantly increased the state 4 respiratory rate. Treatment with saffron, ginsenoside Rg1 and oxymatrine increased the respiratory control rate in cerebral mitochondria isolated from hypoxia-exposed rats in dose-dependent manners in vitro, while ginsenoside Rg1, piperine and oxymatrine significantly increased the mitochondrial membrane potential in cerebral mitochondria from hypoxia-exposed rats. The Chinese herbal monomers saffron, ginsenoside Rg1, piperine and oxymatrine could thus improve cerebral mitochondrial disorders in oxidative phosphorylation induced by hypobaric hypoxia exposure in vitro.

  12. Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats

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    Yoon Hee Lee

    2016-10-01

    Full Text Available It is well established that obesity causes a variety of chronic diseases such as cardiovascular diseases and diabetes. Despite the diligent scientific efforts to find effective ways to lower the level of obesity, the size of obese population grows continuously around the world. Here we present the results that show feeding diet containing HT048, a mixture of the extracts of Crataegus pinnatifida leaves and Citrus unshiu peel, two of the well-known traditional herbal medicines in Eastern Asia, decreases obesity in rats. We fed rats with five different diets for 10 weeks: chow diet (STD, high-fat diet (HFD, high-fat diet with 0.04% orlistat, a drug to treat obesity (HFD + Orlistat, high-fat diet with 0.2% HT048 (w/w; HFD + 0.2% HT048, and high-fat diet with 0.6% HT048 (w/w; HFD + 0.6% HT048. It was found that both body and total white adipose tissue weight of HT048 groups significantly decreased compared to those of the HFD group. Moreover, HT048 decreased serum insulin levels in HFD-fed obese rats. At the molecular level, HT048 supplementation downregulated genes involved in lipogenesis, gluconeogenesis, and adipogenesis, while the expression level of β-oxidation genes was increased. Supplementation-drug interactions are not likely as HFD and HT048-containing diet did not significantly induce genes encoding CYPs. Collectively, this study suggests that HT048 taken as dietary supplement helps to decrease obesity and insulin resistance in HFD-fed obese rats.

  13. Inhibitory Effect of Yongdamsagan-Tang Water Extract, a Traditional Herbal Formula, on Testosterone-Induced Benign Prostatic Hyperplasia in Rats.

    Science.gov (United States)

    Park, Eunsook; Lee, Mee-Young; Jeon, Woo-Young; Lee, Nari; Seo, Chang-Seob; Shin, Hyeun-Kyoo

    2016-01-01

    Yongdamsagan-tang, a traditional herbal formula, is used widely for the treatment of inflammation and viral diseases. In this study, we investigated whether Yongdamsagan-tang water extract (YSTE) affects testosterone propionate- (TP-) induced benign prostatic hyperplasia (BPH) in a rat model. To induce BPH, rats were injected subcutaneously with 10 mg/kg of TP every day. YSTE was administrated daily by oral gavage at doses of 200 and 500 mg/kg along with the TP injection. After 4 weeks, prostates were collected, weighed, and analyzed. The relative prostrate weight was significantly lower in both YSTE groups (200 and 500 mg/kg/day) compared with the TP-induced BPH group. YSTE administration reduced the expression of proliferation markers PCNA, cyclin D1, and Ki-67 and the histological abnormalities observed in the prostate in TP-induced BPH rats. YSTE attenuated the increase in the TP-induced androgen concentration in the prostate. The YSTE groups also showed decreased lipid peroxidation and increased glutathione reductase activity in the prostate. These findings suggest that YSTE effectively prevented the development of TP-induced BPH in rats through antiproliferative and antioxidative activities and might be useful in the clinical treatment of BPH. PMID:27504137

  14. Inhibitory Effect of Yongdamsagan-Tang Water Extract, a Traditional Herbal Formula, on Testosterone-Induced Benign Prostatic Hyperplasia in Rats

    Science.gov (United States)

    Lee, Mee-Young; Lee, Nari

    2016-01-01

    Yongdamsagan-tang, a traditional herbal formula, is used widely for the treatment of inflammation and viral diseases. In this study, we investigated whether Yongdamsagan-tang water extract (YSTE) affects testosterone propionate- (TP-) induced benign prostatic hyperplasia (BPH) in a rat model. To induce BPH, rats were injected subcutaneously with 10 mg/kg of TP every day. YSTE was administrated daily by oral gavage at doses of 200 and 500 mg/kg along with the TP injection. After 4 weeks, prostates were collected, weighed, and analyzed. The relative prostrate weight was significantly lower in both YSTE groups (200 and 500 mg/kg/day) compared with the TP-induced BPH group. YSTE administration reduced the expression of proliferation markers PCNA, cyclin D1, and Ki-67 and the histological abnormalities observed in the prostate in TP-induced BPH rats. YSTE attenuated the increase in the TP-induced androgen concentration in the prostate. The YSTE groups also showed decreased lipid peroxidation and increased glutathione reductase activity in the prostate. These findings suggest that YSTE effectively prevented the development of TP-induced BPH in rats through antiproliferative and antioxidative activities and might be useful in the clinical treatment of BPH.

  15. Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes

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    Seong Eun Jin

    2015-01-01

    Full Text Available Banhasasim-tang (BHSST is a Korean traditional herbal formula comprising eight medicinal herbs. The aim of the present study was to investigate the anti-inflammatory effect of BHSST using macrophage and keratinocyte cell lines. First, we evaluated the effects of BHSST on inflammatory mediator and cytokine production in lipopolysaccharide- (LPS- stimulated RAW 264.7 macrophages. BHSST markedly inhibited the production of nitric oxide (NO, prostaglandin E2 (PGE2, and interleukin- (IL- 6. BHSST significantly suppressed the protein expression of toll-like receptor 4 (TLR4 and phosphorylated nuclear factor-kappa B (NF-κB p65 in RAW 264.7 cells. Second, we examined whether BHSST influences the production of chemokines and STAT1 phosphorylation in tumor necrosis factor-α/interferon-γ TI-stimulated HaCaT keratinocytes. BHSST significantly suppressed the production of RANTES/CCL5, TARC/CCL17, MDC/CCL22, and IL-8 in TI-stimulated HaCaT cells. BHSST also suppressed TI-induced phosphorylation of STAT1 in HaCaT cells. These results suggest that BHSST may be useful as an anti-inflammatory agent, especially for inflammatory skin diseases.

  16. Optimization of the extraction process for the seven bioactive compounds in Yukmijihwang-tang, an herbal formula, using response surface methodology

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    Jung-Hoon Kim

    2014-01-01

    Full Text Available Background: Yukmijihwang-tang (YJT contains multiple bioactive compounds. Heat-reflux extraction was employed and optimized for the extraction of the bioactive compounds in YJT. Objective: The determination of optimal conditions with maximum yields of bioactive compounds, gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, paeoniflorin, benzoic acid and paeonol, in YJT. Materials and Methods: The extraction ratio (ratio of water to herbal formula, extraction time and extraction number were set as individual values and the yields of the seven compounds were the response values that were optimized with a Box-Behnken design. Results: The optimal conditions obtained from response surface methodology (RSM were 1:11.99 for the extraction ratio, 94.53 min for the extraction time and 2.21 for the extraction number. Under the optimal conditions, the response value of the experiment closely agreed with the predicted response value. Conclusions: The result suggests that RSM is successfully applied for optimizing the extraction of the marker compounds in YJT.

  17. Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis

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    Yang Nan

    2011-09-01

    Full Text Available Abstract Background Peanut allergy is characterized by increased levels of peanut-specific IgE in the serum of most patients. Thus, the most logical therapy would be to inhibit the IgE production by committed B-cells. This study aims to investigate the unreported anti-IgE effects of Chinese herbal extracts of Rubia cordifolia (Qiancao and Dianthus superbus (Qumai. Methods Seventy herbal extracts were tested for their ability to reduce IgE secretion by a human B-cell line. Those with the lowest inhibitory concentration 50 (IC50 values were tested in a mouse model of peanut-anaphylaxis. Anaphylactic scores, body temperature, plasma histamine and peanut-specific-immunoglobulins were determined. Results Rubia cordifolia and Dianthus superbus inhibited the in vitro IgE production by a human B-cell line in a dose-dependent manner and the in vivo IgE production in a murine model of peanut allergy without affecting peanut-specific-IgG1 levels. After challenge, all mice in the sham groups developed anaphylactic reactions and increased plasma histamine levels. The extract-treated mice demonstrated significantly reduced peanut-triggered anaphylactic reactions and plasma histamine levels. Conclusion The extracts of Rubia cordifolia and Dianthus superbus inhibited the IgE production in vivo and in vitro as well as reduced anaphylactic reactions in peanut-allergic mice, suggesting potentials for allergy treatments.

  18. Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)

    Institute of Scientific and Technical Information of China (English)

    Susumu Ohwada; Isao Kobayashi; Nobuo Harasawa; Kyoichiro Tsuda; Yosikatsu Inui

    2009-01-01

    Severe acute hepatitis of unknown etiology is difficult to treat and often progresses to subacute fulminant hepatitis or late-onset hepatic failure. A 45-year-old wellnourished, healthy man had progressive fatigue and his liver function tests showed severe liver dysfunction. The etiology of sever acute cholestatic hepatitis was unknown. The liver function tests normalized gradually, which excluded high persistent total bilirubin after starting on predonine. A liver biopsy showed chronic active hepatitis with mild fibrosis (A2, F1). Oral Inchinko-to, a Chinese herbal medicine, at 7.5 g daily was prescribed. The treatment was effective with no adverse effects. We present a successfully treated case and discuss hepatoprotective and choleretic effects of Inchinko-to.

  19. Building Data Mart for Traditional Efficacy of Chinese Herbal Medicine%中药功效数据集市的研制

    Institute of Scientific and Technical Information of China (English)

    曹宜; 佘侃侃

    2012-01-01

    中药功效数据集市以中药功效数据为主题,采用维度建模方法,组织与功效相关的植物分类学信息、化学成分、中药药理信息,采集中药事实型数据和部分文献型数据,根据中药相关学科概念体系,划分维度层次,支持与中药功效相关的多途径、多层次检索,可为中药功效多维分析、数据挖掘和文本挖掘提供基础.%Data mart for traditional efficacy of Chinese herbal medicine is built around traditional efficacy,and dimensional modeling is adopted in this process. Plant taxonomy information, chemical constituents and pharmacological information are collected in the data mart, including the factual data and literature - based data of Chinese herbal medicine. Dimension hierarchy is divided according the concept of traditional Chinese medicine related system disciplines. Data mart for traditional efficacy of Chinese herbal medicine can be searched by multiple ways and levels, and used for multidimensional data analysis, data mining and text mining to reveal the essence of efficacy of Chinese herbs.

  20. Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits.

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    Yujun Hou

    Full Text Available Alzheimer's disease (AD is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS, a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT, Poria cum Radix Pini (PRP and Radix Polygalae (RP, is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.

  1. A Chinese Herbal Preparation Containing Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum Reduces Circulating Adhesion Molecules

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    Kylie A. O’Brien

    2011-01-01

    Full Text Available Circulating adhesion molecules (CAMs, surface proteins expressed in the vascular endothelium, have emerged as risk factors for cardiovascular disease (CVD. CAMs are involved in intercellular communication that are believed to play a role in atherosclerosis. A Chinese medicine, the “Dantonic Pill” (DP (also known as the “Cardiotonic Pill”, containing three Chinese herbal material medica, Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum, has been used in China for the prevention and management of CVD. Previous laboratory and animal studies have suggested that this preparation reduces both atherogenesis and adhesion molecule expression. A parallel double blind randomized placebo-controlled study was conducted to assess the effects of the DP on three species of CAM (intercellular cell adhesion molecule-1 (ICAM-1, vascular cell adhesion molecule-1 and endothelial cell selectin (E-selectin in participants with mild-moderate hypercholesterolemia. Secondary endpoints included biochemical and hematological variables and clinical effects. Forty participants were randomized to either treatment or control for 12 weeks. Treatment with DP was associated with a statistically significant decrease in ICAM-1 (9% decrease, P = .03 and E-Selectin (15% decrease, P = .004. There was no significant change in renal function tests, liver function tests, glucose, lipids or C-reactive protein levels and clinical adverse effects did not differ between the active and the control groups. There were no relevant changes in participants receiving placebo. These results suggest that this herbal medicine may contribute to the development of a novel approach to cardiovascular risk reduction.

  2. A Novel Pharmacological Method to Study the Chinese Medicinal Formula Hua-Zheng-Hui-Sheng-Dan

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    Rui Cao

    2015-01-01

    Full Text Available Objectives. Hua-Zheng-Hui-Sheng-Dan (HZHSD was used as an experimental model to explore research methods of large formulae in traditional Chinese medicine (TCM using current molecular biology approaches. Materials and Methods. The trypan blue exclusion assay was used to determine cell viability and cell numbers. Flow cytometry was used to assess cell cycle distribution and apoptosis. The concentration of cyclin D1 was analyzed by enzyme-linked immunosorbent assay. The median effect principle was used in drug combination studies. An orthogonal experimental design was used to estimate the effects of each herb at different concentrations. The HeLa xenograft mouse model was used to compare the antitumor activity of drugs in vivo. Results. Among the 35 herbs that comprise HZHSD, Radix Rehmanniae Preparata (RRP, Caesalpinia sappan (CS, Evodia rutaecarpa (ER, Folium Artemisiae Argyi (FAA, Leonurus japonicus Houtt (LJH, Tumeric (Tu, Radix Paeoniae Alba (RPA, and Trogopterus Dung (TD effectively inhibited the proliferation of HeLa and SKOV3 cells. Only RRR had an effect on HeLa and SKOV3 cell viability. According to the median effect principle, Angelica sinensis (Oliv. (AS, Tabanus (Ta, and Pollen Typhae (PT, which were proven to have a significant synergistic inhibitory effect on the proliferation of HeLa cells, were added to the original eight positive herbs. The combination of RPA and AS had a synergistic effect on inducing cell cycle S phase arrest and decreasing intracellular cyclin D1 in HeLa cells. By orthogonal experimental design, LJH and Tu were considered unnecessary herbs. The small formula (SHZHSD consisted of RPA, AS, RRR, Ta., TD, PT, ER, CS, and FAA and was able to inhibit cell proliferation and induce cell apoptosis. The antitumor effects of HZHSD and SHZHSD were also compared in vivo. Conclusions. Through molecular biology approaches both in vitro and in vivo, research into single drugs, and analysis using the median effect principle

  3. Problems and Countermeasures on Chinese Herbal Medicine Planting%我国中药材种植存在的问题及对策

    Institute of Scientific and Technical Information of China (English)

    蔡宏伟

    2016-01-01

    中药材种植业处于中医药产业链的最前端,对我国中药材的品质有着直接影响,进而有可能影响到中医疗效和中医药的继承与发展。在我国中药材的种植中,存在着监管效率不高,盲目仓促引种驯化,缺乏全面规划和市场预测,种子种苗问题突出,种植过程缺乏科学化、规范化管理等问题。应当做好监管工作,科学合理引种驯化,做好全面规划,做好种子种苗相关工作以及加强中药材种植过程监管。%The Chinese herbal medicine planting is the first part of the industry chain of the traditional Chinese medical science and Chinese herbal medicines, which has a direct influence on the quality of Chinese herbal medicines and may have an influence on curative effects of tradi-tional Chinese medicine and the inheriting and development.In Chinese herbal medicine planting, there are many problems, such as inefficient supervision, a lack of scientific planning, outstanding problems on seeds and planting stock, a lack of scientific and standardized supervision.We suggest that supervision subjects should be definite and supervision should be professional to enhance the efficiency, overall planning should be made, introduction and domestication should be scientific and reasonable, work of seeds and stock should be improved and supervision of the whole planting procedure should be strengthened.

  4. Serum metabolomics study of Traditional Chinese medicine formula intervention to polycystic ovary syndrome.

    Science.gov (United States)

    Lu, Caixia; Zhao, Xinjie; Li, Yan; Li, Yanjie; Yuan, Chengkun; Xu, Fang; Meng, Xiaoyu; Hou, Lihui; Xu, Guowang

    2016-02-20

    Polycystic ovary syndrome (PCOS) is a most common, heterogeneous, complex endocrinopathy disease. Traditional Chinese medicine (TCM) has been used in the treatment of PCOS for many years. However, the mechanism underlying TCM remains obscure and challenging. In this study, 30 PCOS subjects were separated into normoinsulinemic group (NI=13) and hyperinsulinemic group (HI=17), and treated for three menstrual cycles with TCM Formula, Bushen Huatan Formula (BHF). A metabolomics approach based on ultra-high-performance liquid chromatography (UPLC) coupled with linear ion trap Orbi-trap mass spectrometer (LTQ Orbi-trap MS) is used to investigate serum metabolic changes of TCM intervention to PCOS. After BHF intervention for three menstrual cycles, the serum levels of glycerophosphorylethanolamine (GPEA), creatine, creatinine decreased in both NI and HI groups. Furthermore, in NI group, the main manifestation was the changes of phospholipid metabolism. While in HI group, lysine, phenol sulfate, phe-phe etc. decreased, and ornithine, proline, betaine, acetylcholine etc. increased. Combined with clinical biochemical data, BHF was proved effective to PCOS by reducing the inflammatory reaction and oxidative stress. This study also illustrates that the LC-MS based metabolomic approach is a helpful tool to evaluate curative effect and to understand the mechanisms of TCM. PMID:26730509

  5. 优化中草药调配模式的实践研究%The Practical Research of Optimizing the Mode of the Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    马爽; 高善荣; 赵学敏

    2014-01-01

    Objective By practical research of the dispensing mode of the Chinese herbal medicine,Make sure the realistic significance and the improvement direction of the Chinese herbal medicine intelligent dispensing mode.Method By using comparative study method,compare the traditional dispensing mode and the intelligent dispensing mode.We can find that computer system technolgy,small package of the Chinese herbal pieces and the key auxiliary equipment and facilities of dispensing are the basics in the process of realizing the intelligent dispensing mode;Combined with practical work,analyse the pros and cons of the intelligent dispensing mode by using SWOT analysis method,determine the final dispensing mode of the Chinese herbal medicine of our hospital. Result and Conclusion At present,the intelligent dispensing mode of our hospital has greatly improved the administration of the dispensing mode of the Chinese herbal medicine.This is consistent with our hospital's actual work and the development direction of the administration of the dispensing mode of the Chinese herbal medicine in future.%目的:通过对我院中草药调配模式的实践研究,确证中草药智能配发模式的现实意义和改进方向。方法运用对比研究法,对传统调配模式与现行智能配发模式进行对比,指出计算机系统技术、小袋包装中药饮片、辅助调配的关键设备设施是实现智能调配模式的基础;运用SWOT分析法,结合实际工作,对智能调配模式进行优势劣势分析,最终确证我院优化中草药调配模式的途径。结果与结论目前我院采用的智能调配模式极大改善中草药调配管理,符合我院工作实际,以及当前和今后一段时期内的中草药调配管理发展方向。

  6. Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats

    Directory of Open Access Journals (Sweden)

    I-Min Liu

    2012-01-01

    Full Text Available The present study was undertaken to characterize the effects of Danggui-Shaoyao-San (DSS, a famous traditional Chinese medicine formula consisting of six herbal medicines, on diabetic nephropathy. Streptozotocin-induced diabetic rats were orally administrated DSS (2.8 g kg−1 per day for 12 consecutive weeks. DSS partially decreased the high plasma glucose level in diabetic rats. Diabetic-dependent alterations in urinary albumin, 24-hour urinary albumin excretion rate, and creatinine clearance as well as the kidney hypertrophy (kidney weight/body weight ratio and glomerular mesangial matrix expansion were ameliorated after 12 weeks of DSS treatment. The increased expression of nuclear factor-κB as well as transforming growth factor-β1 and the progressive accumulation of type IV collagen in kidney of diabetic rats were also attenuated by DSS. Not only the elevated levels of advanced glycation end products (AGEs and Nε-(carboxymethyllysine but also the higher levels of lipid peroxidation products in kidney of diabetic rats were ameliorated by DSS. Decreased activity of superoxide diamutase and glutathione peroxidase in kidney of diabetic rats was enhanced by DSS. These data demonstrated that the renoprotective effects of DSS in STZ-diabetic rats not only were attributable to regulate plasma glucose to attenuate AGEs expression in diabetic glomeruli but also likely reflected its antioxidant activity.

  7. Global identification and quantitative analysis of chemical constituents in traditional Chinese medicinal formula Qi-Fu-Yin by ultra-high performance liquid chromatography coupled with mass spectrometry.

    Science.gov (United States)

    Li, Meng-Ning; Dong, Xin; Gao, Wen; Liu, Xin-Guang; Wang, Rui; Li, Ping; Yang, Hua

    2015-10-10

    Qi-Fu-Yin (QFY), a classical traditional Chinese medicine formula, is proven to have significant neuroprotective effects by modern pharmacological studies. However, the chemical constituents of QFY have not been fully explored. In this study, an ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF MS) was developed for comprehensive analysis of chemical constituents in QFY. By using characteristic ions and fragmentation rules, a reliable identification of 156 compounds was described here, including 69 triterpene saponins, 23 oligosaccharide esters, 22 flavanoids, 9 alkaloids, 9 phenolic acids, 8 phthalides, 7 phenylethanoid glycosides, 3 xanthones, 3 sesquiterpene lactones, 2 ionones and 1 iridoid glycoside. Twenty-six major compounds were then determined in a single run by UHPLC coupled with triple quadrupole tandem mass spectrometry (QQQ MS) with fast positive/negative polarity switching. It allows for the acquisition of MS data in both ionization modes from a single run. The proposed method was then validated in terms of linearity, accuracy, precision and recovery. The overall recoveries for 26 analytes ranged from 91.35% to 109.58%, with RSDs ranging from 0.82% to 4.83%. In addition, the content of 26 analytes in QFY prepared by five batches of herbal materials was also analyzed. These results demonstrated that our present method was effective and reliable for comprehensive quality evaluation of QFY. Meanwhile, the study might provide the chemical evidence for revealing the material basis of its therapeutic effects. PMID:26112926

  8. Protective effects of kidney-tonifying Chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson's disease

    Institute of Scientific and Technical Information of China (English)

    Jing Cai; Yun Tian; Ruhui Lin; Xuzheng Chen; Zhizhen Liu; Jindong Xie

    2012-01-01

    The Chinese herbs Herba Epimedii, Fructus Ligustri Lucidi and Rhizoma Polygonati were injected into Parkinson's disease mice established via intraperitoneal injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride. The selective monoamine oxidase B inhibitor selegiline was used as a positive control drug. After successive administration for 4 weeks, Herba Epimedii could downregulate the expression of caspase-3 and increase the brain-derived neurotrophic factor level, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models. Rhizoma Polygonati could downregulate the expression of caspase-3 and FasL, and increase neural growth factor and brain-derived neurotrophic factor levels. Fructus Ligustri Lucidi could downregulate caspase-3 expression. Rhizoma Polygonati and Fructus Ligustri Lucidi did not produce obvious effects on tyrosine hydroxylase activity. Herba Epimedii and Fructus Ligustri Lucidi yielded similar effects on apoptosis-promoting factors to those elicited by selegiline. Herba Epimedii and Rhizoma Polygonati significantly increased the levels of neurotrophic factors compared with selegiline. Herba Epimedii significantly increased tyrosine hydroxylase activity compared with selegiline. It is indicated that the kidney-tonifying Chinese herbal preparation can downregulate the expression of apoptosis-promoting factors, increase neurotrophic factors levels in the substantia nigra and striatum, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models, thereby exerting a stronger or similar neuroprotective effects compared with selegiline.

  9. Herbal Medicines for Acute Kidney Injury: Evidence, Gaps and Frontiers

    Directory of Open Access Journals (Sweden)

    Valérian Bunel

    2015-07-01

    Full Text Available Acute kidney injury (AKI is a major health threat worldwide. The literature on herbal intervention in AKI was searched from English and Chinese databases and reports were critically analyzed in terms of preventing AKI, promoting repair and regeneration, enhancing extrarenal clearance of uremic toxins, and preventing progression to chronic kidney disease (CKD. Altogether, 16 herbal formulae and a few extracts derived from individual herbs were reported to prevent or mitigate AKI in animal models induced by renal ischemia/reperfusion, cisplastin, gentamicin, glycerol, adenine, sepsis or physical exhaustion. Four formulae and six individual herbs were reported to accelerate recovery and/or to prevent CKD in established AKI animal models. Intrarectal herbal medicines, with or without simultaneous oral administration, were reported in six clinical trials and in an animal model to increase extrarenal clearance of uremic toxins. Additional 13 clinical trials reported oral or intravenous herbal interventions in AKI of different etiologies. Despite recurring problems, notably poor compliance with good practice guidelines for clinical trials and for authentication, naming and quality control of herbal materials, accumulating experimental data on the preventive effects of herbal medicines in AKI look encouraging and urge for better, definitive trials to guide clinical practice. Herbal enemas promoting extrarenal clearance of uremic toxins seem cost-effective, but better clinical evidence is certainly needed before any affirmative recommendation be made for AKI patients without access to dialysis. New frontiers, however, lie in those herbal remedies that promote repair/regeneration and prevent chronicity after AKI. Recent experimental data suggest that this may be possible.

  10. Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials.

    Science.gov (United States)

    Song, Ping; Zeng, Lingfeng; Liang, Zhaohui; Wang, Qi; Ou, Aihua

    2016-01-01

    This study aimed to evaluate the efficacy and safety of Chinese herbal medicine auxiliary therapy (CHMAT) in treating childhood cough variant asthma (CVA). A systematic literature review was conducted on RCTs that compared CHMAT, i.e., Chinese herbal medicine (CHM) plus pharmacotherapy (PT), versus the same PT alone in the treatment of CVA. All included trials were assessed for quality and risk bias and analyzed according to the criteria of the Cochrane Handbook based on the Review Manager 5.3 software program. Twenty studies were identified and the CHMAT group had a positive effect on the total effective rate and a lower recurrence rate compared with the control group. CHMAT may have positive effects on CVA, leading to better improvement in disorders of cough and asthma and less adverse effects. However, the methodology and reporting quality of current studies are generally low. Further studies should include larger sample sizes with a strict design to confirm these findings. PMID:27522988

  11. Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats

    OpenAIRE

    Pengsong Liu; Yuanyuan Bian; Hong Zhang(Department of Physics and Center for Quantum Spacetime (CQUeST), Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, 121-742 Korea); Aiming Jia

    2016-01-01

    Ischemia and hypoxia are important physiological changes in diabetic peripheral neuropathy (DPN). Chinese herbal medicine prescription Tangkuei Decoction for Frigid Extremities (TDFE) is useful for increasing blood flow. To help determine whether TDFE could protect the peripheral nerves of diabetic patients from the degeneration caused by high blood glucose, TDFE was administered to streptozotocin-induced diabetic rats for 6 or 12 weeks. Plantar thermal stimulation reaction time thresholds, s...

  12. A Prescribed Chinese Herbal Medicine Improves Glucose Profile and Ameliorates Oxidative Stress in Goto-Kakisaki Rats Fed with High Fat Diet

    OpenAIRE

    Lin Wu; Xiang Li; Hongguang Zhu; Ping Xu; Xin Gao

    2013-01-01

    Oxidative stress (OS) plays a role in hyperglycemia induced islet β cell dysfunction, however, studies on classic anti-oxidants didn't show positive results in treating diabetes. We previously demonstrated that the prescribed Chinese herbal medicine preparation "Qing Huo Yi Hao" (QHYH) improved endothelial function in type 2 diabetic patients. QHYH protected endothelial cells from high glucose-induced damages by scavenging superoxide anion and reducing production of reactive oxygen species. I...

  13. The Efficacy of Chinese Herbal Medicine as an Adjunctive Therapy for Advanced Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis

    OpenAIRE

    Shi Guang Li; Hai Yong Chen; Chen Sheng Ou-Yang; Xi-Xin Wang; Zhen-Jiang Yang; Yao Tong; William C. S. Cho

    2013-01-01

    Many published studies reflect the growing application of complementary and alternative medicine, particularly Chinese herbal medicine (CHM) use in combination with conventional cancer therapy for advanced non-small cell lung cancer (NSCLC), but its efficacy remains largely unexplored. The purpose of this study is to evaluate the efficacy of CHM combined with conventional chemotherapy (CT) in the treatment of advanced NSCLC. Publications in 11 electronic databases were extensively searched, a...

  14. 火针配合中药治疗斑秃疗效观察%Therapeutic Observation of Fire Needling plus Chinese Herbal Medicine for Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    麻秋雷; 梁冰洁; 李鹏; 赵烨; 孟凡征; 李平

    2015-01-01

    目的:观察火针配合中药治疗斑秃的临床疗效。方法将50例斑秃患者随机分为治疗组35例和对照组15例。治疗组采用火针配合中药治疗,对照组采用单纯口服中药治疗。治疗3个月后比较两组临床疗效。结果治疗组总有效率为97.1%,对照组为73.3%,两组比较差异具有统计学意义(P<0.05)。结论火针配合中药是一种治疗斑秃的有效方法。%Objective To observe the clinical efficacy of fire needling plus Chinese herbal medicine in treating alopecia areata. Method Fifty patients with alopecia areata were randomized into a treatment group of 35 cases and a control group of 15 cases. The treatment group was intervened by fire needling plus Chinese herbal medicine, while the control group was by oral administration of Chinese herbal medicine alone. The clinical efficacies were compared after 3-month treatment.Result The total effective rate was 97.1% in the treatment group versus 73.3% in the control group, and the difference was statistically significant (P<0.05).Conclusion Fire needling plus Chinese herbal medicine is an effective method in treating alopecia areata.

  15. Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

    Directory of Open Access Journals (Sweden)

    Yan Li

    2011-01-01

    Full Text Available Use of herbal medicine in the treatment of liver cancer has a long tradition. The compounds derived from the herb and herbal composites are of considerable interest among oncologists. In the past, certain herbal compounds and herbal composite formulas have been studied through in vitro and in vivo as an anti-hepatocellular carcinoma (HCC agent, enhancing our knowledge about their biologic functions and targets. However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice. In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

  16. Analysis of Sheng-Mai-San, a Ginseng-Containing Multiple Components Traditional Chinese Herbal Medicine Using Liquid Chromatography Tandem Mass Spectrometry and Physical Examination by Electron and Light Microscopies.

    Science.gov (United States)

    Cheng, Yung-Yi; Tsai, Tung-Hu

    2016-01-01

    Sheng-Mai-San is a multi-component traditional Chinese herbal preparation. Due to the fact granulated additives, such as starch, carboxymethyl cellulose, lactose and raw herbal powder may alter the content of the bioactive markers in the herbal products, a developed ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was used to measure the herbal biomarkers of ginsenoside Rb₁, Rb₂, Rc, Rd, Re, Rg₁, Rh₁, compound K, ophiopogonin D and schizandrin from the Sheng-Mai-San herbal formulation. Besides, scanning electron microscopy (SEM) was used to observe the morphology of the herbal granular powders. Light microscopy with Congo red and iodine-KI reagent staining was used to identify the cellulose fiber and cornstarch added to pharmaceutical herbal products. The swelling power (SP), water solubility index (WSI), and crude fiber analysis were used to determine the contents of cellulose fiber and cornstarch in pharmaceutical herbal products. In this study, we developed a novel skill to assess the quantification of appended cornstarch in pharmaceutical herbal products using Aperio ImageScope software. Compared with the traditional cornstarch analysis, our analysis method is a rapid, simple and conversion process which could be applied to detect the percentage of added cornstarch in unknown powder products. The various range of the herbal content for the five pharmaceutical manufacturers varied by up to several hundreds-fold. The physical examination reveals that the morphology of the herbal pharmaceutical products is rough and irregular with sharp layers. This study provides a reference standard operating procedure guide for the quality control of the Chinese herbal pharmaceutical products of Sheng-Mai-San. PMID:27598107

  17. Study on the Effect of Chinese Herbal Medicine in Regulating Peritoneal Lymphatic Stomata and Enhancing Drainage of Ascites in Mice with Liver Fibrosis

    Institute of Scientific and Technical Information of China (English)

    李继承; 袁淑慧; 赵坚培; 吕志连

    2001-01-01

    Objective: To observe the regulating effect of Chinese herbal medicine on peritoneal lymphatic stomata and its significance in treating ascites in liver fibrosis model mice. Methods: Two Chinese herbal compound prescriptions were used separately to treat the carbon tetrachloride induced mouse model of liver fibrosis, the histo-pathologic changes in mice were observed by using scanning electron microscope and processed by computer image processing. The changes of urinary volume and sodium ion concentration were measured, too.Results: In the treated group, the histo-pathologic changes were significantly less than those in the control group, the peritoneal lymphatic stomata enlarged with increased number of opening and higher density in distribution and the urinary volume and sodium ion excretion increased after treatment. Conclusion: Chinese herbal medicine has marked effect in alleviating liver fibrosis, regulating peritoneal lymphatic stomata, improving the drainage of ascites from peritoneal cavity, causing increase of urinary volume and sodium ion excretion to reduce water and sodium retention, and thus have favorable therapeutic effect in treating ascites.

  18. Effect of Chinese Herbal Medicinal Ingredients on IL-2 mRNA Levels of T Lymphocytes in Mice Measured Using Semiquantification RT-PCR

    Institute of Scientific and Technical Information of China (English)

    CHU Yue-feng; YAN Xin-min; LI Xiang-rui; HU Yuan-liang

    2006-01-01

    In this study, the IL-2 mRNA levels of T lymphocytes in normal mice stimulated by nine Chinese herbal medicinal ingredients (CHMIs) were measured using semiquantification reverse transcription polymerase chain reaction. The results showed that astragalus polysaccharide (APS), epimedium polysaccharide (EPS), Chinese angelica polysaccharide (CAPS), propolis flavone (PF), and astrogalosides (AS) promoted IL-2 mRNA levels in T lymphocytes in vitro and in vivo to differing degrees, and the level of IL-2 mRNA induced by propolis polysaccharide (PPS) in vitro was higher than that induced by the control, which differed from that of PPS in vivo.

  19. Evaluation of acute and sub-chronic toxicities of ulcer fast and reg;: a bi-herbal formula in male Wistar albino rats

    Directory of Open Access Journals (Sweden)

    Kingsley C. Patrick-Iwuanyanwu

    2014-12-01

    Full Text Available The acute and sub-chronic toxicities of ulcer fast and reg; (UF - A commercial bi-herbal formula prepared with Alstonia boonei and Xylopia aethiopica in male Wistar albino rats was evaluated. There was no mortality in rats administered 2000 mg/kg body weight (BW of UF in an acute toxicity study. A significant (p and #8804;0.05 increase in daily consumption of feed and fluid intake in experimental rats after 28 days was recorded followed by a progressive increase in BW of rats administered 50, 100 and 200 mg/kg BW of UF in a dose-dependent manner. Alanine amino transferase, aspartate amino transferase, alkaline phosphatase, lactate dehydrogenase, triacylglycerides and creatinine increased significantly (p and #8804;0.05 in rats treated with UF, whereas urea and fasting blood sugar decreased significantly (p and #8804;0.05 in a dose-dependent manner when compared with control. There was a marginal decrease in serum calcium ion and phosphate ion following the administration of UF when compared with control. Packed cell volume and hemoglobin decreased significantly (p and #8804;0.05 in rats treated with UF, whereas white blood cell increased significantly (p and #8804;0.05 in a dose-dependent manner when compared with control. Histological examination of the liver, kidney, heart and lungs showed normal architecture in control group, whereas hepatocytes of rats treated with 50, 100 and 200 mg/kg BW of UF were characterized by slight periportal fatty change, marked change and ballooning degeneration. Heart muscle of rats treated with 200mg/kg BW of UF showed slight inflammation while histological examination of the lungs showed areas of interstitium damage and diffuse alveolar damage in rats treated with UF. In conclusion, indiscriminate administration of UF could be of public health concern and long-term exposure may cause a significant potential health risk. [Int J Basic Clin Pharmacol 2014; 3(6.000: 970-977

  20. Antinociceptive and Anti-inflammatory Activities of a Chinese Herbal Recipe (DJW in Animal Models

    Directory of Open Access Journals (Sweden)

    P Kunanusorn

    2009-03-01

    Full Text Available Summary: Since in our previous study, Duhuo Jisheng Wan (DJW, which means pill of pubescent angelica root and mulberry mistletoe combination, demonstrates clinically comparable efficacy to diclofenac in the symptomatic treatment of osteoarthritis (OA of the knee after 4 weeks of treatment.  Therefore, in order to verify its mechanisms of action, this study was performed to investigate the antinociceptive and anti-inflammatory activities of DJW in various animal models.  The antinociceptive activity of DJW was investigated by using the formalin test in mice model.  The acute inflammatory model using the carrageenin-induced hind paw edema in rats and the chronic inflammatory model using the cotton pellet-induced granuloma formation in rats were utilized.  Results showed that DJW possessed a marked antinociceptive activity in both phases of the formalin test in mice.  However, in the carrageenin-induced hind paw edema model, which is known to be sensitive to cyclooxygenase (COX inhibitors, DJW showed an insignificant anti-inflammatory effect, and in the cotton pellet-induced granuloma model, it had no antigranuloma formation and showed no effect on the transudate weight.  In addition, DJW showed no suppressive effects on weight gain and the thymus weight of the rats.  In conclusion, the overall results demonstrate that DJW possess both central and peripheral antinociceptive activities.  However, its anti-inflammatory activity, if any, could not be demonstrated in these two inflammatory models in the present study and remains to be elucidate.   Industrial relevance: Since drug therapy in OA patients, such as paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs, and topical analgesics may prove ineffective in some patients, and long-term therapy with NSAIDs often have been associated with serious adverse effects.  Such patients are turning increasingly to herbal medicines and DJW may be an alternative since it demonstrates clinically

  1. [Method of traditional Chinese medicine formula design based on 3D-database pharmacophore search and patent retrieval].

    Science.gov (United States)

    He, Yu-su; Sun, Zhi-yi; Zhang, Yan-ling

    2014-11-01

    By using the pharmacophore model of mineralocorticoid receptor antagonists as a starting point, the experiment stud- ies the method of traditional Chinese medicine formula design for anti-hypertensive. Pharmacophore models were generated by 3D-QSAR pharmacophore (Hypogen) program of the DS3.5, based on the training set composed of 33 mineralocorticoid receptor antagonists. The best pharmacophore model consisted of two Hydrogen-bond acceptors, three Hydrophobic and four excluded volumes. Its correlation coefficient of training set and test set, N, and CAI value were 0.9534, 0.6748, 2.878, and 1.119. According to the database screening, 1700 active compounds from 86 source plant were obtained. Because of lacking of available anti-hypertensive medi cation strategy in traditional theory, this article takes advantage of patent retrieval in world traditional medicine patent database, in order to design drug formula. Finally, two formulae was obtained for antihypertensive. PMID:25850277

  2. Effectiveness of Chinese herbal medicine for cancer palliative care: overview of systematic reviews with meta-analyses.

    Science.gov (United States)

    Chung, Vincent C H; Wu, Xinyin; Hui, Edwin P; Ziea, Eric T C; Ng, Bacon F L; Ho, Robin S T; Tsoi, Kelvin K F; Wong, Samuel Y S; Wu, Justin C Y

    2015-01-01

    Chinese herbal medicines (CHM) are often used in managing cancer related symptoms but their effectiveness and safety is controversial. We conducted this overview of meta-analyses to summarize evidence on CHM for cancer palliative care. We included systematic reviews (SRs) with meta-analyses of CHM clinical trials on patients diagnosed with any type of cancer. Methodological quality of included meta-analyses was assessed with the Methodological Quality of Systematic Reviews (AMSTAR) Instrument. Fifty-one SRs with meta-analyses were included. They covered patients with lung (20 SRs), gastric (8 SRs), colorectal (6 SRs), liver (6 SRs), breast (2 SRs), cervical (1 SR), esophageal (1 SR), and nasopharyngeal (1 SR) cancers. Six SRs summarized evidence on various types of cancer. Methodological quality of included meta-analyses was not satisfactory. Overall, favorable therapeutic effects in improving quality of life among cancer patients have been reported. Conflicting evidence exists for the effectiveness of CHM in prolonging survival and in reducing chemotherapy and/or radiotherapy related toxicities. No serious adverse effects were reported in all included studies. Evidence indicated that CHM could be considered as an option for improving quality of life among patients receiving palliative care. It is unclear if CHM may increase survival, or reduce therapy related toxicities.

  3. Radix Astragali-Based Chinese Herbal Medicine for Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    2016-01-01

    Background. Treatment of chemotherapy-induced peripheral neuropathy (CIPN) remains a big challenge for oncologists. The aim of this study is to evaluate the effects of Radix Astragali- (RA-) based Chinese herbal medicine in the prevention and treatment of oxaliplatin-induced peripheral neuropathy, including the incidence and grading of neurotoxicity, effective percentage, and nerve conduction velocity. Methods. All randomized controlled trials (RCTs) were found using PubMed, Cochrane, Springer, China National Knowledge Infrastructure (CNKI), and Wanfang Database of China Science Periodical Database (CSPD) by keyword search. Meta-analysis was conducted using RevMan 5.0. Results. A total of 1552 participants were included in 24 trials. Meta-analysis showed the incidence of all-grade neurotoxicity was significantly lower in experimental groups and high-grade neurotoxicity was also significantly less. Effective percentage was significantly higher and sensory nerve conduction velocity was improved significantly, but changes in motor nerve conduction velocity were not statistically significant. No adverse events associated with RA-based intervention were reported. Conclusion. RA-based intervention may be beneficial in relieving oxaliplatin-induced peripheral neuropathy. However, more double-blind, multicenter, large-scale RCTs are needed to support this theory. Trial Registration. PROSPERO International prospective register of systematic reviews has registration number  CRD42015019903.

  4. Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

    Directory of Open Access Journals (Sweden)

    Thomas Efferth

    2011-09-01

    Full Text Available In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV, bovine viral diarrhoea virus (BVDV—a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects on host embryonic bovine trachea (EBTr cells, while Evodia lepta, Hedyotis diffusa and Glycyrrhiza spp. demonstrated promising activities against the HBV without toxic effects on host human hepatoblastoma cells transfected with HBV-DNA (HepG2 2.2.15 cells. Seven organic extracts from Alpinia oxyphylla, Coptis chinensis, Kadsura longipedunculata, Arctium lappa, Panax ginseng, Panax notoginseng and Saposhnikovia divaricata inhibited T. b. brucei. Moreover, among fifteen water extracts that combined high antiproliferative activity (IC50 0.5–20 µg/mL and low acute in vitro toxicity (0–10% reduction in cell viability at IC50, Coptis chinensis presented the best beneficial characteristics. In conclusion, traditional herbal medicine from Europe and China still has a potential for new therapeutic targets and therapeutic applications.

  5. Ancient Records and Modern Research on the Mechanisms of Chinese Herbal Medicines in the Treatment of Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Hai-ming Zhang

    2015-01-01

    Full Text Available Over the past decades, Chinese herbal medicines (CHM have been extensively and intensively studied through from both clinical and experimental perspectives and CHM have been proved to be effective in the treatment of diabetes mellitus (DM. This study, by searching ancient records and modern research papers, reviewed CHM in terms of their clinical application and principal mechanism in the treatment of DM. We summarized the use of CHM mentioned in 54 famous ancient materia medica monographs and searched papers on the hypoglycemic effect of several representative CHM. Main mechanisms and limitations of CHM and further research direction for DM were discussed. On the basis of the study, we were led to conclude that TCM, as a main form of complementary and alternative medicine (CAM, was well recorded in ancient literatures and has less adverse effects as shown by modern studies. The mechanisms of CHM treatment of DM are complex, multilink, and multitarget, so we should find main hypoglycemic mechanism through doing research on CHM monomer active constituents. Many CHM monomer constituents possess noteworthy hypoglycemic effects. Therefore, developing a novel natural product for DM and its complications is of much significance. It is strongly significant to pay close attention to CHM for treatment of DM and its complications.

  6. Ancient Records and Modern Research on the Mechanisms of Chinese Herbal Medicines in the Treatment of Diabetes Mellitus

    Science.gov (United States)

    Zhang, Hai-ming; Liang, Feng-xia

    2015-01-01

    Over the past decades, Chinese herbal medicines (CHM) have been extensively and intensively studied through from both clinical and experimental perspectives and CHM have been proved to be effective in the treatment of diabetes mellitus (DM). This study, by searching ancient records and modern research papers, reviewed CHM in terms of their clinical application and principal mechanism in the treatment of DM. We summarized the use of CHM mentioned in 54 famous ancient materia medica monographs and searched papers on the hypoglycemic effect of several representative CHM. Main mechanisms and limitations of CHM and further research direction for DM were discussed. On the basis of the study, we were led to conclude that TCM, as a main form of complementary and alternative medicine (CAM), was well recorded in ancient literatures and has less adverse effects as shown by modern studies. The mechanisms of CHM treatment of DM are complex, multilink, and multitarget, so we should find main hypoglycemic mechanism through doing research on CHM monomer active constituents. Many CHM monomer constituents possess noteworthy hypoglycemic effects. Therefore, developing a novel natural product for DM and its complications is of much significance. It is strongly significant to pay close attention to CHM for treatment of DM and its complications. PMID:25815039

  7. Clinical efficacy and safety of Chinese herbal medicine for Wilson's disease: a systematic review of 9 randomized controlled trials.

    Science.gov (United States)

    Wang, Yan; Xie, Cheng-long; Fu, Deng-lei; Lu, Lin; Lin, Yan; Dong, Qi-qian; Wang, Xiao-tong; Zheng, Guo-qing

    2012-06-01

    Wilson's disease is an autosomal recessive disorder of copper metabolism. Despite being treatable, there is no universally accepted treatment regimen. Currently, various Chinese herbal medicines (CHMs) are widely used in the treatment of Wilson's disease in China, but there is a lack of reliable scientific evidence for the effectiveness of such therapies. The objective of this systematic review is to assess the clinical efficacy and safety of CHM as an alternative or/and adjuvant therapy for Wilson's disease. A systematic literature search in different medical databases was performed to identify randomized controlled trials comparing CHM as monotherapy or CHM as adjuvant therapy with western conventional medical therapy in the treatment of Wilson's disease. A total of 687 participants were included in nine eligible studies. The main findings are that CHM as monotherapy or adjuvant therapy for Wilson's disease may be able to improve the clinical symptoms, to promote the urinary copper excretion, to ameliorate liver function and/or liver cirrhosis, and has fewer adverse effects in comparison with western conventional medication. Furthermore, CHM generally appeared to be safe and well tolerated in patients with Wilson's disease. However, the evidence presented in this review are insufficient to warrant a clinical recommendation due to the generally low methodological quality of the included studies. In conclusion, CHM seems to be beneficial and safe for Wilson's disease, but high-quality evidences are still needed to further evaluate this therapy. Therefore, additional well-designed, randomized, placebo-controlled clinical trials are needed.

  8. A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

    Directory of Open Access Journals (Sweden)

    Shu-Chen Chien

    2014-01-01

    Full Text Available Jia-wei-xiao-yao-san (JWXYS is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied. The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN- induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects. After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT and serum glutamic pyruvic transaminase (SGPT levels were significantly elevated, whereas the albumin level decreased. Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated. In addition, JWXYS treatment prevented liver fibrosis induced by DMN. JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats. Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury. The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.

  9. Chinese Herbal Medicines as an Adjunctive Therapy for Unresectable Pancreatic Cancer: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Bin Li

    2015-01-01

    Full Text Available Pancreatic cancer is a common malignancy with a high mortality. Most patients present clinically with advanced pancreatic cancer. Moreover, the effect of radiotherapy or chemotherapy is limited. Complementary and alternative medicines represent exciting adjunctive therapies. In this study, we ascertained the beneficial and adverse effects of Chinese herbal medicine (CHM in combination with conventional therapy for inoperable pancreatic cancer by using meta-analysis methods for controlled clinical trials. We extracted data for studies searched from six electronic databases that were searched and also assessed the methodological quality of the included studies. We evaluated the following outcome measures: 6-month and 1-year survival rate, objective response rate, disease control rate, quality of life, and adverse effects. The final analysis showed CHM is a promising strategy as an adjunctive therapy to treat advanced or inoperable pancreatic cancer and that CHM in combination with conventional therapy is a promising strategy for resistant disease. However, convincing evidence must be obtained and confirmed by high-quality trials in future studies.

  10. 基于均匀设计的中药有效组分复方配伍研究%Uniform designed research on the active ingredients assembling of Chinese herbal for antioxidative capacity

    Institute of Scientific and Technical Information of China (English)

    杨鸿; 吴彦; 马琰岩; 吕俊海; 李晶哲

    2012-01-01

    Objective To find a suitable way of quantitative composition-activity relationship of Chinese herbal for antioxidative capacity based on uniform design. Method Chinese herbal active ingredient formula was composed of Total flavonoids of Glycyrrhiza (TFG) , ginkgo biloba extract (GBE) , Total fa-vonoids of epimedium (TFE) and astragaloside (AST) . The herbal efficacy was detected by scavenging the free radical of DPPH in vitro, and the mathematical model was constructed to describe the connection between different combinations and their antioxidative capacity by the method of LARS regression. Result The best effect was in the ratio of TFG 0. 8 mg/ml,GBE 3.144 mg/ml,TFE 0.024 mg/ml,AST 0.036 mg/ml. Conclusion Uniform designed research is one of efficient ways to describe the quantitative composition-activity relationship.%目的 探索基于均匀设计的中药抗氧化有效组分复方的研究分析方法.方法 采用均匀设计和改进最小角回归分析,对甘草总黄酮、银杏叶提取物、淫羊藿总黄酮和黄芪总苷组成的中药组分复方不同配比体外清除DPPH自由基的作用进行研究.结果 通过分析获得了中药组分配伍清除DPPH的回归方程,优化组合后进行药效学验证,结果显示该中药组分配伍最佳剂量组合为甘草总黄酮0.8 mg/ml、银杏叶提取物3.144 mg/ml、淫羊藿总黄酮0.024 mg/ml和黄芪总苷0.036 mg/ml.结论 上述中药组分配伍后能有效清除DPPH自由基;本实验采用的均匀设计结合改进最小角回归分析适合"非线性、小样本"生物实验数据数据分析,为筛选评价抗氧化中药有效组分复方提供了合适的研究方法.

  11. 中国中草药饲料添加剂的现状与展望%Current Status and Prospect of Chinese Herbal Feed Additives in China

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    This review summarizes the present situation of research, development and application of the Chinese herbal feed additives and its prospect. It can provide scientific references for researchers to carry out in-depth study. Chinese herbal feed additives will hopefully solve problems such as antibiotic residues, environmental pollu-tion, low productivity which hinders the development of livestock and provides strong support for developing green husbandry, meeting the food safety demand, closing the gap of livestock between the developed countries and Chi-na, increasing competitiveness of Chinese animal products in world markets. The development of Chinese herbal feed additives have very important economic and social benefits.%  本文综述了中草药饲料添加剂的研究、开发和应用现状及其发展前景,为研究者继续深入开展研究提供科学的参考。中草药添加剂有望解决长期困扰畜牧业发展的抗生素残留、提高生产率低、环境污染、安全性等问题,为发展绿色畜牧业、满足人民的食品安全需求、缩小我国畜牧业与发达国家的差距、增强我国畜产品在国际市场的竞争力提供有力支持,中草药饲料添加剂的发展具有重要的经济社会效益。

  12. Study on the Disease Prevention of Silver Carps Bighead by Chinese Herbal Medicine%中草药对鲢鳙鱼病害防治研究

    Institute of Scientific and Technical Information of China (English)

    杨军; 刘远高; 邹四新; 何志刚; 袁祖菊

    2013-01-01

    通过人工感染鲢鳙鱼试验研究了五倍子、大黄、地锦草、苦楝、白头翁、乌桕、辣蓼及铁苋菜对鲢鳙鱼常见病害的治疗效果.结果表明,中草药对于其常见病害具有一定的防治作用,为鲢鳙鱼病害防治提供了参考.%Effect of gallnut,rhubarb,humifuse euphorbia herb,neem,Chinese pulsatilla root,Chinese tallow tree,red-knees herb and copperleaf therapeutic on silver carps bighead common diseases were studied by artificial infection test.The results showed that Chinese herbal medicine for the common disease had a certain control effect,which provided some references for disease prevention and treatment of silver carps bighead.

  13. Chinese Herbal Medicine as an Adjunctive Therapy for Breast Cancer: A Systematic Review and Meta-Analysis

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    Libing Zhu

    2016-01-01

    Full Text Available Chinese herbal medicine (CHM has been widely used as an adjunctive therapy for breast cancer, while its efficacy remains unexplored. The purpose of this study is to evaluate the efficacy of CHM combined with chemotherapy for breast cancer. The study results showed that CHM combined with chemotherapy significantly increased tumor response and KPS as compared to using chemotherapy alone (RR = 1.36; 95% CI = 1.24–1.48; P<0.00001; RR = 1.38; 95% CI = 1.26–1.52; P<0.00001, resp.. Besides, CHM as an adjunctive therapy significantly reduced the nausea and vomiting at toxicity grade of III–IV (RR = 0.37; 95% CI = 0.27–0.52; P<0.00001. Moreover, the combined therapy significantly prevented the decline of WBC in patients under chemotherapy at toxicity grade of III–IV (RR = 0.49; 95% CI = 0.34–0.69; P<0.00001 and prevented the decline of platelet at toxicity grade of III–IV or I–IV (RR = 0.29; 95% CI = 0.12–0.73; P=0.008; RR = 0.77; 95% CI = 0.63–0.94; P=0.009, resp.. This study suggests that CHM combined with chemotherapy in comparison with chemotherapy alone can significantly enhance tumor response, improve KPS, and alleviate toxicity induced by chemotherapy in breast cancer patients. However, a firm conclusion could not be reached due to the lack of high quality trials and large-scale RCTs, so further trials with higher quality and larger scale are needed.

  14. Increase of insulin sensitivity in diabetic rats received Die-Huang-Wan, a herbal mixture used in Chinese traditional medicine

    Institute of Scientific and Technical Information of China (English)

    WU Yang-Chang; HSU Jen-Hao; LIU I-Min; LIOU Shorong-Shii; SU Hui-Chen; CHENG Juei-Tang

    2002-01-01

    AIM: Effects on insulin sensitivity of Die-Huang-Wan, the herbal mixture widely used to treat diabetic disorder in Chinese traditional medicine, were investigated in vivo. METHODS: The obese Zucker rats were employed as insulin-resistant animal model. Also, insulin-resistance was induced by the repeated intraperitoneal injections of long-acting human insulin at 0.5 U/kg three times daily into adult male Wistar rats. Insulin resistance was identified using the loss of tolbutamide (10 mg/kg) or electroacupuncture (EA)-induced plasma glucose lowering action. The plasma glucose concentration was examined by glucose oxidase assay. RESULTS: The plasma glucose-lowering action induced by tolbutamide was significantly enhanced in obese Zucker rats receiving the repeated administration of Die-Huang-Wan at dosage of 26 mg/kg for 3 d. Furthermore, administration of Die-Huang-Wan delayed the formation of insulin resistance in rats that were induced by the daily repeated injection of human long-acting insulin at 0.5 U/kg three times daily and identified by the loss of tolbutamide- or EA-induced hypoglycemia. In streptozotocininduced diabetic rats, oral administration of metformin at 320 mg/kg once daily made an increase of the response to exogenous short-acting human insulin 15 d later. This is consistent with the view that metformin can increase insulin sensitivity. Similar treatment with Die-Huang-Wan at an effective dose (26.0 mg/kg) also increased the plasma glucose lowering action of exogenous insulin at 10 d later. The effect of Die-Huang-Wan on insulin sensitivity seems to produce more rapidly than that of metformin. CONCLUSION: The present study found that oral administration of Die-Huang-Wan increased insulin sensitivity and delayed the development of insulin resistance in rats.

  15. Study on Treatment of Polycystic Ovarian Syndrome with Infertility by Combined Therapy of Chinese Herbal Medicine and Compound Cyproterone Acetate

    Institute of Scientific and Technical Information of China (English)

    TAO Li-li (陶莉莉); CHEN Xiao-ping (陈小平); GU Zheng-tian (顾正田)

    2003-01-01

    Objective: To evaluate the effect of combined therapy of Chinese herbal medicine and compound cyproterone acetate (CPA) in treating non-obesity polycystic ovarian syndrome (PCOS) and to explore its mechanism in improving withdrawal ovulation. Methods:Eighty-six patients of non-obesity PCOS, typed as Shen-deficiency with blood stasis Syndrome or Shen-deficiency with Phlegm-Dampness Syndrome by Syndrome Differentiation in traditional Chines medicine, were randomly divided into three groups: (1) The TCM group (n=26) was treated with Chinese drugs for 6 menstrual cycles; (2) The western medicine (WM) group (n=30) was treated with 1 tablet of CPA for 21 days, with the treatment beginning from the 5th day of menstruation. The treatment was given for 3 menstrual cycles by repetitious medication, which stopped and restarted on the 5th day of withdrawal bleeding. Then the ovulation promoting therapy was applied by using clomifene citrate and human chorionic gonadotropin (CC/Hcg) for 3 menstrual cycles; (3) The TCM-WM group (n=30) was treated with the medications used for the above two groups. The menstrual cycle, the volume and duration of the menstruation, as well as the improvement of acne and pilosis [Ferriman-Gallway (F-G) scoring]were observed after 3 cycles ended. Moreover, condition of ovulation was monitored by B-ultrasonography at the 4th-6th cycle and status of pregnancy was observed. Results: Compared with before treatment, the blood level of luteinizing hormone (LH) and testosterone (T) in all 3 groups after treatment significantly decreased (P<0.05), with its ratio to follicle-stimulating hormone (LH/FSH) recovered to normal, but without markedly change in levels of FSH, estradiol (E2) and prolactin (PRL). The menstrual cycle in most patients got regular and acne significantly alleviated (P<0.05), and the improvement of infrequent menstruation and acne was better in the WM group and the TCM-WM group than that in the TCM group, but pilosis showed no significant

  16. Effects of the Chinese Herbal Medicine Based on Hachimi-jio-gan in Male Rats with the Adenine-Induced Osteopenia

    Institute of Scientific and Technical Information of China (English)

    Takeshi Ogirima; Kaori Tano; Masayuki Kanehara; Ming Gao; Xiuyun Wang; Yi Guo; Yanjun Zhang; Liping Guo; Torao Ishida

    2005-01-01

    In the adenine-induced renal failure rats, reversibility of renal failure and recovery of bone mineral density (BMD) by discontinuation of adenine-rich diet were reported: We think that the effect to bone metabolism with medication may be able to be evaluated as reinforcement of the BMD recovery. We have so far investigated the Chinese herbal medicine based on Hachimi-jio-gan (HJG) which are more effective than HJG alone. In this study, we investigated the effects of our Chinese herbal prescription on BMD in the adenine-treated rats compared to that of vitamin D3treatment. Young male rats were administrated 100 mg/ml adenine for 8 weeks, and they showed renal failure and bone loss. The adenine-treated rats were divided into the following 3 groups, that is, the group experienced no treatment (control), the group givenour Chinese herbal medicine (HAO), and the group given vitamin D3 (VD3) medication. It is likely that VD3 medication was less effective for increase of the femoral BMD than increase of the spinal BMD. In contrast, HAO was effective for increase of the femoral BMD. The VD3 group showed low deoxypyridinoline (Dpd: bone resorption maker) as compared to the control group.However, the HAO group showed same or slightly high Dpd. It is suggested that VD3 may increase BMD by reduction of bone resorption, while HAO may show effect on BMD by activating bone metabolism. It is indicated that HAO may become a curative medicine for bone loss because of the different target site from vitamin D3.

  17. A Hexa-Herbal TCM Decoction Used to Treat Skin Inflammation: An LC-MS-Based Phytochemical Analysis.

    Science.gov (United States)

    Chang, Jennifer B; Lane, Majella E; Yang, Min; Heinrich, Michael

    2016-07-01

    In order to understand the chemical relationship between a traditional hexa-herbal Chinese medicine formula and botanical drugs it is derived from, an analytical platform comprising liquid chromatography coupled with triple quadrupole mass spectrometry and data mining was developed to separate and identify key chemical components. The hexa-herbal formula comprises the rootstock of Scutellaria baicalensis, Rheum tanguticum, Sophora flavescens, the root bark of Dictamnus dasycarpus, the bark of Phellodendron chinense, and the fruit of Kochia scoparia. Seventy-three compounds including alkaloids, anthraquinone derivatives, coumarins, coumarins derivatives, flavonoids, flavone glycosides, naphthalene derivatives, phenylbutanone glucopyranoside, phenolic acids, pterocarpans, stilbenes, stilbenes derivatives, and tannins were putatively identified based on mass measurement and characteristic fragment ions. Among the botanical drugs of the hexa-herbal Chinese medicine formula, the rootstock of R. tanguticum and S. flavescens, bark of P. chinense, and rootstock of S. baicalensis contributed to the majority of the extracted metabolites of the formula decoction. The developed method appeared to be a versatile tool for monitoring chemical constituents in extracts of a traditional Chinese medicine formula in a relatively comprehensive and systematic manner, and helped to understand the importance of the individual botanical drugs within a formulation. PMID:27272397

  18. Chinese Herbal Medicine and Acupuncture Used for Rehabilitation of the Impaired Urinary System in Patients with Paraplegia -A Report of 52 Cases

    Institute of Scientific and Technical Information of China (English)

    邹颖; 周文艳

    2005-01-01

    @@ Infection of the urinary system is frequently seen in the paraplegic patients with urinary complications,which is one of the main reasons for the late death in such cases. The effects of the therapeutic method adopted for the urinary rehabilitation are directly related to the life quality and survival time of the paraplegic patients. Since 1999-2002, the authors had applied Chinese herbal medicine combined with acupuncture for the urinary rehabilitation in 52 paraplegic patients, with quite good therapeuticresults as reported in the following.

  19. Will the Europe Union's Traditional Herbal Medicinal Products Directive (Directive 2004/24/EC) be against traditional Chinese medicine in EU market?

    Science.gov (United States)

    Xu, Juncai; Liu, Min; Xia, Zhijie

    2013-05-01

    As human civilization develops, biomedicine stays robust. Faced with the challenge of Europe Union's Traditional Herbal Medicinal Products Directive, if traditional Chinese medicine (TCM) wants to be still used as one kind of medicine to treat patients, China should be in line with scientific law, that is, each claim that TCM treats any disease or indication should be supported by the data of evidence-based randomized clinical trials. As a priority, there is an urgent need to conduct more scientific experiments and clinical trials to verify the concepts and mechanisms of TCM. Also, China is encouraged to get rid of non-scientific concepts and theories of TCM. PMID:23829802

  20. Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant Paeonia lactiflora

    Directory of Open Access Journals (Sweden)

    Jin-Yuan Ho

    2014-04-01

    Full Text Available Bai Shao (BS, the root of Paeonia lactiflora Pall., a common Chinese herb in many recipes used to treat viral infection and liver diseases, is recognized for its ability to nourish menstruation, its Yin convergence, and as an antiperspirant. However, the mechanism and components for its antiviral function remain to be elucidated. In this study, an ethanolic extract of BS was further partitioned into aqueous and organic parts (EAex for in vitro functional study and in vivo efficacy testing. EAex exhibited an IC50 of 0.016 ± 0.005 mg/mL against influenza virus A/WSN/33 (H1N1, with broad-spectrum inhibitory activity against different strains of human influenza A viruses, including clinical oseltamivir-resistant isolates and an H1N1pdm strain. The synthesis of both viral RNA and protein was profoundly inhibited when the cells were treated with EAex. A time-of-addition assay demonstrated that EAex exerted its antiviral activity at various stages of the virus replication cycle. We addressed its antiviral activity at virus entry and demonstrated that EAex inhibits viral hemagglutination and viral binding to and penetration into host cells. In vivo animal testing showed that 200 mg/kg/d of EAex offered significant protection against viral infection. We conclude that BS possesses antiviral activity and has the potential for development as an anti-influenza agent.

  1. Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications

    Institute of Scientific and Technical Information of China (English)

    Paola Zanoli; Augusta Benelli; Manuela Zavatti; Marianna Rivasi; Claudia Baraldi; Mario Baraldi

    2008-01-01

    Aim: To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats. Methods: The extract was administered at doses of 30, 60 and 120 mg/kg by oral gavage, acutely (one time, 45 rain before mating test) or subchronically (daily for 10 days) in sexually potent and sexually sluggish/impo-tent rats. Sexual behavior, serum levels of luteinizing hormone (LH) and testosterone (T) were evaluated in treated rats and compared with controls receiving vehicle. The effect of the extract on central dopaminergic neurotransmis-sion was assessed in the nucleus accumbens using a microdialysis technique. Results: In sexually potent rats, both acute and subchronic treatment with the extract dosed at 30 and 60 mg/kg reduced mount latency and intromission latency. In sluggish/impotent rats, the acutely administered extract at the dose of 60 mg/kg shortened ejaculation latency, whereas subchronically administered at the doses of 30 and 60 mg/kg, reduced mount, intromission and ejaculation latencies, increasing also the percentage of mounting and ejaculating rats. The extract dosed at 60 mg/kg significantly increased LH and T following acute and subchronic administration and increased 3,4-dihydroxyphenylacetic acid levels in the nucleus accumbens, 30 rain after the acute administration. Conclusion: The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be scribed to increased serum T level in parallel with the activation of the central dopaminergic system.

  2. Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound

    Institute of Scientific and Technical Information of China (English)

    Xiao-Lu Liang; Jia-Ying Yuan

    2013-01-01

    Objective:To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali, Salvia miltiorrhiza and Angelica sinensis, and TCM +praziquantel on liver fibrosis in rabbits with schistosomiasis. Methods: The hepatic fibrosis model in rabbits with schistosomiasis was established. The experimental animals (24 rabbits) were randomly divided into four groups (group A, B, C and D, n=6). Group A (control group) was only treated by praziquantel; Group B was treated by mixture of Radix astragali and Salvia miltiorrhiza +praziquantel; Group C was treated by mixture of Radix astragali and Angelica sinensis +praziquantel; Group D was treated by mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis +praziquantel. Then B-ultrasonogram was used to evaluate the effects. Results: Each group showed certain curative effect on liver fibrosis in rabbits with schistosomiasis. The efficacy of group B, C and D was better than group A, and that of group D was the best. The differences in long diameter, thickness diameter, transverse diameter and portal vein inner diameter of liver before and after treatment were statistically significant (P<0.05). The liver function indexes and liver fibrosis indexes were significantly improved after treatment (P<0.05). Conclusions:The mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis combined with Western medicine treatment can obviously improve the efficacy on liver fibrosis of schistosomiasis.

  3. The role of Chinese herbal medicines in a rat model of chronic colitis

    Institute of Scientific and Technical Information of China (English)

    Xiao Lan Tian; Marisabel Mourelle; Yu Ling Li; Francisco Guarner; Juan-R Malagelada

    2000-01-01

    AIM To investigate a mixture of traditional Chinese medicine (TCM) in the prevention of chronic colitis inrats.METHODS Sixty rats were divided into 3 groups. Colitis was induced by trinitrobenzene-sulfonic acid(TNB). On day 10, all the survived rats were killed, the mortality and intestinal obstruction rate werecalculated, the colonic lesion score was assessed and collagenase activity and collagen concentration weremeasured.RESULTS The survival rate was much lower and intestinal obstruction rate much higher in TNB than thosein TCM, they were 53% and 81% vs. 80% and 24% (P<0.05 and P<0.01, respectively). There were alsosignificant differences in colonic stricture score and colonic weight between TNB and TCM groups (1.75±1.2 vs 0.22±0.67 and 0.57±0.36 vs 0.31±0.10, P<0.01 and P<0.05, respectively). No hydroxyprolineand collagenase activity differences were found between the two groups.CONCLUSION This mixture of TCM prevents the formation of intestinal stricture, increases the survivalrate and decreases intestinal obstruction rate in a rat model of chronic colitis.

  4. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine

    Institute of Scientific and Technical Information of China (English)

    Rui WANG; Han YAN; Xi-can TANG

    2006-01-01

    Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action. HupA has been found to improve cognitive deficits in a broad range of animal models. HupA possesses the ability to protect cells against hydrogen peroxide, β-amyloid protein (or peptide), glutamate,ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53, and caspase-3, protect mitochondria, upregulate nerve growth factor and its receptors, and interfere with amyloid precursor protein metabolism. Antagonizing effects of HupA on N-methyl-D-aspartate receptors and potassium currents may also contribute to its neuroprotection as well. Pharmacokinetic studies in rodents, canines, and healthy human volunteers indicated that HupA was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate with the property of slow and prolonged release after oral administration. Animal and clinical safety tests showed that HupA had no unexpected toxicity, particularly the dose-limiting hepatotoxicity induced by tacrine. The phase Ⅳ clinical trials in China have demonstrated that HupA significantly improved memory deficits in elderly people with benign senescent forgetfulness, and patients with Alzheimer disease and vascular dementia, with minimal peripheral cholinergic side effects and no unexpected toxicity. HupA can also be used as a protective agent against organophosphate intoxication.

  5. Herbal Medicine

    Science.gov (United States)

    ... for its scent, flavor, or therapeutic properties. Herbal medicines are one type of dietary supplement. They are ... and fresh or dried plants. People use herbal medicines to try to maintain or improve their health. ...

  6. Oral treatment with the herbal formula B401 protects against aging-dependent neurodegeneration by attenuating oxidative stress and apoptosis in the brain of R6/2 mice

    Directory of Open Access Journals (Sweden)

    Wang SE

    2015-11-01

    Full Text Available Sheue-Er Wang,1,2 Ching-Lung Lin,1 Chih-Hsiang Hsu,1 Shuenn-Jyi Sheu,3 Chung-Hsin Wu1 1Department of Life Science, National Taiwan Normal University, Taipei, 2Department of Pathological Inspection, Saint Paul’s Hospital, Taoyuan, 3Brion Research Institute of Taiwan, Taipei, Taiwan Background: Neurodegeneration is characterized by progressive neurological deficits due to selective neuronal loss in the nervous system. Huntington’s disease (HD is an incurable neurodegenerative disorder. Neurodegeneration in HD patients shows aging-dependent pattern. Our previous study has suggested that a herbal formula B401 may have neuroprotective effects in the brains of R6/2 mice. Objective: To clarify possible mechanisms for neurodegeneration, which improves the understanding the aging process. This study focuses on clarifying neurodegenerative mechanisms and searching potential therapeutic targets in HD patients. Methods: The oxidative stress and apoptosis were compared in the brain tissue between R6/2 HD mice with and without oral B401 treatment. Expressions of proteins for oxidative stress and apoptosis in the brain tissue of R6/2 HD mice were examined by using immunostaining and Western blotting techniques. Results: R6/2 HD mice with oral B401 treatment significantly reduced reactive oxygen species levels in the blood, but markedly increased expressions of superoxide dismutase 2 in the brain tissue. Furthermore, R6/2 HD mice with oral B401 treatment significantly increased expressions of B-cell lymphoma 2 (Bcl-2, but significantly reduced expressions of Bcl-2-associated X protein (Bax, calpain, and caspase-3 in the brain tissue. Conclusion: Our findings provide evidence that the herbal formula B401 can remedy for aging-dependent neurodegeneration of R6/2 mice via suppressing oxidative stress and apoptosis in the brain. We suggest that the herbal formula B401 can be developed as a potential health supplement for ameliorating aging

  7. Local use of iontophoresis with traditional Chinese herbal medicine, e.g., Gu-Sui-Bu (Rhizoma Drynariae may accelerate orthodontic tooth movement

    Directory of Open Access Journals (Sweden)

    Yongming Li

    2013-01-01

    Full Text Available Introduction: Mechanical force is not the only means to cause tooth movement, but just one kind of stimuli for it. Biological stimuli, with potential of accelerating alveolar bone remodeling, other than mechanical force, have been attracted by orthodontists who are combating prolonged treatment duration. It has been approved that some traditional Chinese medicines, such as Gu-Sui-Bu (Rhizoma Drynaria, affect the process of bone remodeling. The Hypothesis: We make the hypothesis that local use of iontophoresis with Gu-Sui-Bu (Rhizoma Drynaria as a non-invasive and safe drug delivery system with no trauma, risk of infection or damage to patients is a new potential approach for accelerating orthodontic tooth movement, and shorten the orthodontic treatment time. Evaluation of the Hypothesis: Gu-Sui-Bu is effective at inducing bone remodeling, and iontophoresis as a non-invasive technique for drug delivery, is suitable for the transmission of some traditional Chinese herbal medicines into periodontal tissues.

  8. Clinical Observation on the Combined Treatment of 57 Cases of Non-small Cell Lung Cancer Using Argon-Helium Cryosurgery and Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To observe the clinical effect of the combined therapy using argon-helium cryosurgery (Ar-He knife) and Chinese herbal medicine in treating non-small cell lung cancer (NSCLC).Methods: Fifty-seven patients of NSCLC were treated with the combined therapy and observed. Results:The treatment was successfully completed in all patients with mild adverse reactions. The effective rate was 83.8% 3 months after the operation, 79.6% 6 months after the operation, and 77.3% 12 months after the operation, with median survival of 9 months. The survival rate after 12 months was 46.67%(21/45), 34.62% (9/26) after 18 months, and 36.36% (4/11) after 24 months. Conclusion: Argon-helium cryosurgery therapy is superior in its assured orientation, quick tumor load deprivation and less postoperational reaction. Combined with Chinese herbal medication, Argon-helium cryosurgery therapy can prolong survival time, relieve clinical symptoms, and elevate the quality of life in NSCLC patients, and is thus worthy of promotion.

  9. Study on preventive and therapeutic effect of Chinese medicinal herbal extracts on rat with bone marrow injury induced by radiation exposure

    International Nuclear Information System (INIS)

    Objective: To examine the effect of Chinese medicinal herbal extracts, Danggui (Radix angelicae sinensis), Chuanxiong (Rhizoma chuanxiong), Huangqi (Radix astragali), and Danshen (Radix salviae miltiorrhizae) on rats with bone marrow injury induced with whole-body gamma-ray exposure. Methods: Sixty male rats were randomly divided into three groups, control group, model group (irradiation only with no administration of the extracts), and drug treatment group (irradiation and administration of Chinese medicinal herbal extracts). Rats were irradiated with 6 Gy cobolt-60 gamma rays after administration of the extracts for two weeks. The number of marrow nucleate cells was counted, and VEGF and PDGF expression were measured with Western blot method on the 7th day since the irradiation. Results: Bone marrow nucleate cells and VEGF and PDGF expression in bone marrow cells in the model group were significantly lower than those in the control group (P<0.01), and these values in the drug treatment group were significantly higher than those in the model group (P<0.01 or P<0.05). Conclusion: The extracts of Chuanxiong, Danggui, Huangqi, and Danshen can be used to prevent from ration bone marrow injury in rats. (authors)

  10. A Comparative Study of Selected Trace Element Content in Malay and Chinese Traditional Herbal Medicine (THM Using an Inductively Coupled Plasma-Mass Spectrometer (ICP-MS

    Directory of Open Access Journals (Sweden)

    Sharifah Mohamad

    2013-02-01

    Full Text Available A total of 60 products of traditional herbal medicine (THM in various dosage forms of herbal preparation were analyzed to determine selected trace elements (i.e., Zn, Mn, Cu, Cd, and Se using ICP-MS. Thirty types of both Chinese and Malay THMs were chosen to represent each population. The closed vessel acid microwave digestion method, using CEM MARS 5, was employed for the extraction of the selected trace elements. The digestion method applied was validated by using certified reference material from the Trace Element in Spinach Leaves (SRM1570a. The recoveries of all elements were found to be in the range of 85.3%–98.9%. The results indicated that Zn, Mn, Cu, Cd and Se have their own trends of concentrations in all samples studied. The daily intake concentrations of the elements were in the following order: Mn > Zn > Cu > Se > Cd. Concentrations of all five elements were found to be dominant in Chinese THMs. The essentiality of the selected trace elements was also assessed, based on the recommended daily allowance (RDA, adequate intake (AI and the United States Pharmacopeia (USP for trace elements as reference. The concentrations of all elements studied were below the RDA, AI and USP values, which fall within the essential concentration range, except for cadmium.

  11. The journey,gain,and thought from engaging in the research of Chinese herbal medicines in China,Japan,and United States%The journey, gain, and thought from engaging in the research of Chinese herbal medicines in China, Japan, and United States

    Institute of Scientific and Technical Information of China (English)

    LIUYan-ze; DENG Zhu-ping

    2011-01-01

    Since early 80s of last century,Chinese herbal medicines focused on the isolation and structural identification of active/chemical compounds have being investigated,started the journey from Henan College of Traditional Chinese Medicine.After one year (1985~ 1986) advanced study in Prof.Jingxi Xie's laboratory in the Institute of Materia Medica,Chinese Academy of Medical Sciences in Beijing,further studies in Prof.Takuo Okuda's laboratory,Okayama University,Japan as a guest researcher from 1988 to 1992 opened a fresh and amazing gate of tannin chemistry.Near 10 years'investigation of tannins and related polyphenols from Chinese herbal medicines,supported by National Natural Science Foundation of China and other grants,some typical herbs containing tannins and related polyphenols as major active components have been in-depth studied,such as Loropetalum chinense,Epilobium angustifolium,Rhodmyrtus tomentosa,Lythrum salicaria,Epilobium pyrricholophum,Rodgersia podoph ylla,Punica granatum,Euphorbia humifusa,and Cornus of ficinalis etc.Hundreds of diversified tannins and related polyphenols have been isolated including monomer,dimmer,trimer of ellagitannins and C-glycosidic tannins etc.

  12. Searching for Synergistic Bronchodilators and Novel Therapeutic Regimens for Chronic Lung Diseases from a Traditional Chinese Medicine, Qingfei Xiaoyan Wan

    OpenAIRE

    Yuanyuan Hou; Binfeng Cheng; Mengge Zhou; Runping Fang; Min Jiang; Wenbin Hou; Gang Bai

    2014-01-01

    Classical Chinese pharmacopeias describe numerous excellent herbal formulations, and each prescription is an outstanding pool of effective compounds for drug discovery. Clarifying the bioactivity of the combined mechanisms of the ingredients in complex traditional Chinese medicine formulas is challenging. A classical formula known as Qingfei Xiaoyan Wan, used clinically as a treatment for prevalent chronic lung disease, was investigated in this work. A mutually enhanced bioactivity-guided ult...

  13. Herbal Medicines for Acute Kidney Injury:Evidence, Gaps and Frontiers

    Institute of Scientific and Technical Information of China (English)

    Vale´ rian Bunel; Fan Qu; Pierre Duez; Qi-he Xu

    2015-01-01

    Acute kidney injury (AKI) is a major health threat worldwide. The literature on herbal intervention in AKI was searched from English and Chinese databases and reports were critically analyzed in terms of preventing AKI, promoting repair and regeneration, enhancing extrarenal clearance of uremic toxins, and preventing progression to chronic kidney disease (CKD). Altogether, 16 herbal formulae and a few extracts derived from individual herbs were reported to prevent or mitigate AKI in animal models induced by renal ischemia/reperfusion, cisplastin, gentamicin, glycerol, adenine, sepsis or physical exhaustion. Four formulae and six individual herbs were reported to accelerate recovery and/or to prevent CKD in established AKI animal models. Intrarectal herbal medicines, with or without simultaneous oral administration, were reported in six clinical trials and in an animal model to increase extrarenal clearance of uremic toxins. Additional 13 clinical trials reported oral or intravenous herbal interventions in AKI of different etiologies. Despite recurring problems, notably poor compliance with good practice guidelines for clinical trials and for authentication, naming and quality control of herbal materials, accumulating experimental data on the preventive effects of herbal medicines in AKI look encouraging and urge for better, definitive trials to guide clinical practice. Herbal enemas promoting extrarenal clearance of uremic toxins seem cost-effective, but better clinical evidence is certainly needed before any affirmative recommendation be made for AKI patients without access to dialysis. New frontiers, however, lie in those herbal remedies that promote repair/regeneration and prevent chronicity after AKI. Recent experimental data suggest that this may be possible.

  14. The Prescription Pattern of Chinese Herbal Products That Contain Dang-Qui and Risk of Endometrial Cancer among Tamoxifen-Treated Female Breast Cancer Survivors in Taiwan: A Population-Based Study

    OpenAIRE

    Chien-Tung Wu; Jung-Nien Lai; Yueh-Ting Tsai

    2014-01-01

    PURPOSE: The increased practice of traditional Chinese medicine worldwide has raised concerns regarding herb-drug interactions. We analyzed the usage of Chinese herbal products containing dang-qui and investigated whether dang-qui therapy increases endometrial cancer risk among tamoxifen-treated breast cancer survivors in Taiwan. METHODS: All patients newly diagnosed with invasive breast cancer who received tamoxifen treatment from January 1, 1998, to December 31, 2008 were selected from the ...

  15. Herbal treatment for osteoporosis: a current review.

    Science.gov (United States)

    Leung, Ping-Chung; Siu, Wing-Sum

    2013-04-01

    Osteoporosis is an aging problem. The declining bone mineral density (BMD) enhances the chances of fractures during minor falls. Effective pharmaceuticals are available for a rapid improvement of BMD. However, hormonal treatment gives serious complications, and bisphosphonates may lead to odd fractures of long bones, resulting from excessive rigidity of the cortical components. Many medicinal herbs used in Traditional Chinese Medicine, known as kidney tonics, have been tested for their effects on bone metabolism in the laboratory and clinically. Three of these, viz. Herba epimedii (, Yín Yáng Huò), Fructus ligustri lucidi (, Nǚ Zhēn Zi), and Fructus psoraleae (, Bǔ Gǔ Zhī) were chosen to form a herbal formula, ELP. ELP was tested on in vitro platforms and was shown to have both osteoblastic and anti- osteoclastic action. ELP tested on ovariectomized rats also showed BMD protection. ELP was then put on a placebo- controlled randomized clinical trial. BMD protection was obvious among those women with the onset of menopause beyond 10 years (P 0.05). Although a thorough literature review on the herbal treatment effects did not give convincing answers to the use of Chinese herbs in osteoporosis, our study supports more research and trials in this area, while we are looking for safe and effective agents to keep the bone metabolism in a balanced state. PMID:24716161

  16. Effect of Chinese Herbal Feed Additive on Meat Quality of Rex Rabbit%中草药饲料添加剂对獭兔肉品质的影响

    Institute of Scientific and Technical Information of China (English)

    袁政委; 蒲万霞; 陈国顺; 刘渤涛; 高海霞

    2009-01-01

    [Objective] The aim of this study was to provide a theoretical basis for population and application of Chinese herbal feed additive in the rex rabbit breeding. [Method] 108 weaned-rex rabbits aged 40 days were divided into three groups with thirty-six each group. Group A were fed basal diet, while group B were fed basal diet supplemented with 0.3% Chinese herbal feed additive and group C were fed basal diet supplemented with 0.4% Chinese herbal feed additive. The meat quality indexes were measured when feeding to 150 age in days. [Result] There was significant difference among pH value, water loss rate, storing loss rate and crude protein content in each group (P<0.05), but no significant difference was found in tenderness, cooking percentage, moisture content and crude fat content (P>0.05). The total content of amino acids, essential amino acids and semi essential amino acids as well as main delicious amino acids was highest in group C accounting for 23.84%, 11.47% and 8.32% respectively, next came group B accounting for 20.94%, 10.64% and 6.81% respectively, and lowest in group C (control group) accounting for 19.06%, 9.61% and 6.46% respectively. [Conclusion] The Chinese herbal feed additive can improve meat quality of rex rabbit the best addition of 0.4%.

  17. 鲁安中药材基地喷灌设计与安装%Sprinkler Design and Realization of Ru ' an Chinese Herbal Medicines Base

    Institute of Scientific and Technical Information of China (English)

    陈志明

    2012-01-01

    中药材种植基地的喷灌系统,要求既满足灌溉需要又不影响中药材收获对象的产量和质量.结合中药材喷灌工程实例,阐述了管道布置、喷头选择、喷头间距和支管间距的确定、主管与支管的管径计算、管道水头损失计算、喷灌强度计算、水泵选配等喷灌设计方法以及开挖管道沟、安装管道和立杆、安装水泵和控制系统、安装喷头等施工过程和注意事项,全部设计安装过程为大面积生产基地的基础农业设施建设提供了参考.%The sprinkler system of Chinese herbal medicines planting base must meet the irrigation needs without affecting the yield and quality of traditional Chinese medicine gains. With Chinese herbal medicines irrigation engineering us the example, this article tries to explain irrigation design methods like piping, sprinkler head selection, determination of sprinkler head and branch pipe spacing, pipe diameter calculation of primary and branch pipe, pipe head loss calculation, sprinkler irrigation calculation and water pumps selection. Tvis article also tries to explain the construction process and some items of trench excavation, installation of pipe and pole, pumps and control systems, sprinklers installation and other construction process. The whole design installation process provided references for infrastructure agriculture construction in large-scale production base.

  18. 21种中草药提取物对MRSA的抗菌作用研究%Antibacterial Effects of 21 Extracts of Chinese Herbal Medicine on MRSA

    Institute of Scientific and Technical Information of China (English)

    傅若秋; 余琼; 孟德胜; 卢来春; 张雪梅

    2011-01-01

    目的:研究21种中草药提取物对11株耐甲氧西林金黄色葡萄球菌(MRSA)的体外抗茵作用.方法:采用96孔板培养法和涂片法测定各提取物对MRSA的抑茵率及杀菌率.结果:仙鹤草、半枝莲、夏枯草等8种中草药对MRSA具有较强的抗菌活性,其中仙鹤草醇提物、半枝莲水提物抑茵活性最强,浓度为6.25 mg·mL-1时抑茵率均达100%;仙鹤草水提物的杀茵活性最强,浓度为25 mg·mL-1时杀菌率迭100%.结论:仙鹤草、半枝莲提取物具有明显的抗MRSA作用.%OBJECTIVE: To study the antibacterial effects of 21 extracts of Chinese herbal medicine on MRS A in vitro. METHODS: The antibacterial ratio and bactericidal rate of each extract of Chinese herbal medicine were determined by 96-well multiwell plates and direct smear method. RESULTS: 8 Chinese herbal medicines had antibacterial activities on MRSA, such as Agrimoniapi-losa, Scutellaria barbata and Prunella vulgaris. The ethanol extracts of A. Pilosa and water extracts of S. Barbata had the strongest antibacterial activity, and the antibacterial ratio of them reached 100% as the concentrations of them were 6.25 mg·mL'-1 The bactericidal rate of water extracts of A. Pilosa was the highest, reaching 100% as the concentration of it was 25 mg·mL'-1 CONCLUSION: The extracts of A. Pilosa and S. Barbata show clear antibacterial effects on MRSA.

  19. 复方黄芩喷雾剂的抗真菌临床试验%The clinical experiments about Chinese herbal compound Huangqin spray in treatment the disease of the fungal skin

    Institute of Scientific and Technical Information of China (English)

    陈鹏英; 金德珍; 戴蜀平

    2011-01-01

    目的:临床试验观察复方黄芩喷雾剂对皮肤浅层真菌病治疗情况.方法:以益康唑的疗效进行对照,观察外用皮肤浅层真菌感染部位,考察复方黄芩喷雾剂的疗效.结果:复方黄芩喷雾剂对皮肤浅层真菌病疗效显著,其与益康唑在治疗皮肤浅层真菌病无显著性差异,无明显不良反应.结论:复方黄芩喷雾剂可作为治疗皮肤浅层真菌病的复方中药外用制剂,值得推广.%OBJECTIVE To research the clinical experiments about Chinese herbal compound Huangqin spray in treatment disease of the fungal skin. METHODS Apply the medicine on the area of the fungal skin. The detective medicine was Chinese herbal compound Huangqin spray. The reference medicine was Econazole lotion. RESULTS The curative effect of Chinese herbal compound Huangqin spray in treatment the disease of the fungal skin was well and obvious. Its curative effect was well and obvious as Econazole lotion. CONCLUSION The medicine of Chinese herbal compound Huangqin spray is for external use. The Chinese herbal compound can be used in treatment the disease of the fungal skin.

  20. In vivo effects of Chinese herbal recipe, Danshaohuaxian, on apoptosis and proliferation of hepatic stellate cells in hepatic fibrotic rats

    Institute of Scientific and Technical Information of China (English)

    Xiao-Xia Geng; Qin Yang; Ru-Jia Xie; Xin-Hua Luo; Bing Han; Li Ma; Cheng-Xiu Li; Ming-Liang Cheng

    2005-01-01

    AIM: To investigate the effects of Danshaohuaxian (DSHX),a Chinese herbal recipe, on the apoptosis and cell cycles of hepatic stellate cells (HSCs) in rat hepatic fibrosis and its possible mechanisms. METHODS: Seventy-six male Wistar rats were randomly divided into normal control group, hepatic fibrosis group,non-DSHX-treated group and DSHX-treated group. Except for the normal control group, rat hepatic fibrotic models were induced by subcutaneous injection of carbon tetrachloride (CCl4), drinking alcohol, giving diet of hyperlipid and hypoprotein for 8 wk. When the hepatic fibrotic models were produced, 12 rats of hepatic fibrosis group (15 rats survived, others died during the 8 wk) were sacrificed to collect blood and livers. HSCs were isolated from the other 3 rats to detect the apoptotic index (AI) and cell cycles by flow cytometry. DSHX was then given to the DSHX-treated group (1.0 g/kg, PO daily) for 8 wk. At the same time, normal control group and non-DSHX-treated group were given normal saline for 8 wk. At end of the experiment, some rats in these three groups were sacrificed to collect blood and livers, the other rats were used for HSC isolation to detect the apoptotic index (AI) and cell cycles. Then the liver index, serum hyaluronic acid (HA) and alanine aminotransferase (ALT),degree of hepatic fibrosis, urinary excretion of hydroxyproline (Hyp) and expression of collagen types Ⅰ and Ⅲ (COL Ⅰ and Ⅲ) in these four groups were detected respectively.RESULTS: Compared with the indexes of the hepatic fibrosis group and non-DSHX-treated group, the DSHX-treated group revealed a liver index of (0.0267±0.0017 vs 0.0423±0.0044, 0.0295±0.0019, P<0.05), levels of serum HA (200.78±31.71 vs316.17±78.48, 300.86±72.73, P<0.05)and ALT(93.13±5.79 vs 174.5±6.02, 104.75±6.54, P<0.01),and stage of hepatic fibrosis (1.30 vs 4.25, 2.60, P<0.01)all reduced. The urinary excretion of Hyp increased (541.09±73.39 vs 62.00±6.40, 182.44±30.83, P<0

  1. An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica – Fritillaria usuriensis dropping pills for pulmonary diseases

    OpenAIRE

    Tao, Jin; Hou, Yuanyuan; Ma, Xiaoyao; Dan LIU; Tong, Yongling; Zhou, Hong; Gao, Jie; Bai, Gang

    2016-01-01

    Background Traditional Chinese medicine (TCM) herbal formulae provide valuable therapeutic strategies. However, the active ingredients and mechanisms of action remain unclear for most of these formulae. Therefore, the identification of complex mechanisms is a major challenge in TCM research. Methods This study used a network pharmacology approach to clarify the anti-inflammatory and cough suppressing mechanisms of the Chinese medicinal preparation Eriobotrya japonica – Fritillaria usuriensis ...

  2. Traditional Chinese medicine formula Qing Huo Yi Hao as superoxide anion scavenger in high glucosetreated endothelial cells

    Institute of Scientific and Technical Information of China (English)

    Qiong xu; Bin ZHANG; Xiao-mu LI; Xin GAO

    2012-01-01

    Aim:To investigate the effects of a traditional Chinese medicine formula Qing Huo Yi Hao (QHYH)and its components on hydroxyl radical (HO·)production in vitro and the activity of QHYH against free radicals in cultured endothelial cells induced by high glucose.Methods:Hydroxyl radicals (HO·)were generated through Fenton reactions in vitro,and 5,5-dimethyl-1-pyrroline N-oxide (DMPO)was used as a spin trap to form DMPO/HO·adducts detected using electron paramagnetic resonance (EPR).Immortalized mouse cerebral microvascular endothelial (bEnd.3)cells were treated with high glucose (35 mmol/L).The free radical scavenging ability of QHYH in the cells was evaluated using EPR.Superoxide dismutase (SOD)was used to identify the free radicals scavenged by QHYH in the cells.Results:QHYH and its 8 components concentration-dependently reduced DMPO/HO· signaling.The DMPO/HO· adduct scavenging ability of QHYH was 82.2%,which was higher than each individual component.The free radical scavenging ability of 1% QHYH in high glucose-treated bEnd.3 cells was approximately 70%.In these cells,the free radicals were also specifically reduced by SOD (400 U/mL),implying that the free radicals were primarily superoxide anions.Conclusion:The results demonstrate that the QHYH formula is potent antioxidant acting as scavenge of superoxide anions in high glucose-treated endothelial cells.

  3. Study on the Effect of Chinese Herbal Medicine in Regulating Peritoneal Lymphatic Stomata and Enhancing Drainage of Ascites in Mice with Liver Fibrosis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    [1]Ballardini G, Fallani M, Biagini G, et al. Desmin and actin in the identification Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Achiv B Cell Pathol 1998;56(1):45-49.[2]Runyon BA, Sugano S, Kanel G. A rodent model of cirrhosis, ascites, and bacterial peritonitis. Gastroenterology 1991;100(3):489-493.[3]LI J, LI YH, XUE JC, et al. Protective effect of Tanshinine on experimental damage of hepatocytes. Chinese J of Integrated Traditional and Western Medicine on Liver Dis 1996;6(3):29-31.[4]WANG LT. The cytological mechanism of Chinese herbal medicines in antagonizing liver fibrosis. Chinese J of Integrated Traditional and Western Medicine on Liver Dis 1997;7(4):249-252.[5]LI J, YU S. Study on the ultrastructure of the peritoneal stomata in humans. Acta Anat 1991;141(1):26-31.[6]LI J, LU Z, WU N, et al. A scanning electron microscopy and computer image processing morphometric study of the pharmacological regulation of patency of the peritoneal stomata. Acta Anat 1996;178(5):443-447.

  4. Effect of Chinese medicinal herbal residues on microbial community succession and anti-pathogenic properties during co-composting with food waste.

    Science.gov (United States)

    Zhou, Ying; Selvam, Ammaiyappan; Wong, Jonathan W C

    2016-10-01

    This study investigated the antimicrobial properties of Chinese medicinal herbal residues (CMHRs) during its co-composting with food waste (FW) in two different ratios along with a control. Inhibition on total microbial population were assessed while the numerically dominant microbes were isolated and their antagonistic effects were assessed. Results indicate that the active ingredients persist in the composting mass did not affect the microbes unspecifically as revealed from almost similar bacterial and fungal populations. Rather specific inhibitory activities against Alternaria solani and Fusarium oxysporum were observed. Apart from the CMHR-born active compounds, CMHR-induced changes in the antagonistic and mycoparasitic abilities of the bacteria and fungi also contribute to the specific inhibition against the tested pathogens. Therefore use of CMHRs during the composting of CMHRs enhances its antipathogenic property resulting in an anti-pathogenic compost. PMID:27039351

  5. The spectrum-effect relationship-a rational approach to screening effective compounds, reflecting the internal quality of Chinese herbal medicine.

    Science.gov (United States)

    Zhu, Chun-Sheng; Lin, Zhi-Jian; Xiao, Ming-Liang; Niu, Hong-Juan; Zhang, Bing

    2016-03-01

    Since the chromatographic fingerprint was introduced, it has been accepted by many countries to assess the quality and authenticity of Chinese herbal medicine (CHM). However, solely using the chromatographic fingerprint to assay numerous chemicals is not suitable for the assessment of the whole internal quality and pharmacodynamics of CHM. Consequently, it is necessary to develop a rational approach to connecting the chromatographic fingerprint with effective components to assess the internal quality of CHM. For this purpose, a spectrum-effect relationship theory was proposed and accepted as a new method for the assessment of CHM because of its potential use to screen effective components from CHM. In this paper, we systematically reviewed the application of the spectrum-effect relationship theory in the research of CHM, including research mentality, different chromatographic analysis techniques, data processing technologies, and structure determination. PMID:27025364

  6. Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models

    Directory of Open Access Journals (Sweden)

    Long Cheng

    2014-01-01

    Full Text Available Traditional Chinese medicines largely lack adequate and scientifically rigorous evidence regarding efficacy and functional mechanisms. The present study was aimed to confirm the hypoglycemic effect of Tangningtongluo (TNTL formula, a traditional Chinese Miao medicine, in two animal models: high-fat diet and streptozotocin- (STZ- induced diabetic rats and C57BL/KsJ-db/db diabetic mice. After 4 weeks, TNTL intervention in STZ-induced diabetic rats yielded in significant improvement on the glucose tolerance test. Moreover, the islet histopathology showed that oral TNTL reduced the severity of islet necrosis in pancreases tissue. Compared with diabetic controls, a 12-week TNTL treatment regimen (dosages = 0.9, 1.8, and 3.6 g/kg in db/db mice significantly decreased fasting glucose and HbA1c. Additionally, oral glucose tolerance in TNTL-treated mice improved significantly, compared with diabetic mice receiving metformin. Finally, tissue histopathology and biochemical index evaluations revealed significant improvement in TNTL-treated mice. Taken together, our results show that TNTL exerted a strong hypoglycemic effect in two diabetic rodent animal models, preserving β-cells in the pancreas islet and reducing the risk of diabetic retinopathy and nephropathy.

  7. Advance Research on Anti-gout Effects of Chinese Herbal Medicine%抗痛风中草药的研究进展

    Institute of Scientific and Technical Information of China (English)

    张小军; 谢丽莎; 唐文均; 龚志强

    2016-01-01

    ABSTRACT:With the development of society and improvement of human living standards,the incidence of gout dis-ease is increasing,accompanied with younger occurrence trend.Gout disease is caused by sodium crystals deposition in the joints and surrounding tissues,which characterized by disorders of purine metabolism.The drugs in western medicine commonly used for anti-gout are colchicine,non-steroidalanti-inflammatory drugs,adrenocorticotropic hor-mone and glucocorticoid.In recent years,Chinese herbal anti-gout medicine research has made great progress.The paper reviews the Chinese herbal anti-gout medicine.%随着社会发展和人类生活水平的提高,痛风疾病的发病率不断增加并且还伴着发病年龄出现低龄化趋势。痛风是一种以高尿酸血症导致尿酸钠晶体在关节及其周围组织沉积为特征的嘌呤代谢性疾病。在西药上常用来抗痛风的药物有秋水仙碱、非甾体类抗炎药、促肾上腺皮质激素、糖皮质激素等。近年来抗痛风药物中草药的研究也取得很大进步,本文就有关抗痛风中草药的研究进行综述。

  8. A Chinese Herbal Medicine, Tokishakuyakusan, Reduces the Worsening of Impairments and Independence after Stroke: A 1-Year Randomized, Controlled Trial

    OpenAIRE

    Hirozo Goto; Nobuhiko Satoh; Yoshinori Hayashi; Hiroaki Hikiami; Yutaka Nagata; Ryosuke Obi; Yutaka Shimada

    2011-01-01

    In post-stroke patients, the recurrence of stroke and progression of impairments lead to a bedridden state and dementia. As for their treatments, only anti-hypertension and anti-coagulation therapies to prevent the recurrence of stroke are available. In Asia, post-stroke patients with impairments are often treated with herbal medicine. The present study evaluated the effectiveness of tokishakuyakusan (TS) in improving the impairment and independence in post-stroke patients. Thirty-one post-st...

  9. Hydrolysis of Glycosidic Flavonoids during the Preparation of Danggui Buxue Tang: An Outcome of Moderate Boiling of Chinese Herbal Mixture

    Directory of Open Access Journals (Sweden)

    Wendy Li Zhang

    2014-01-01

    Full Text Available Chemical change during boiling of herbal mixture is a puzzle. By using Danggui Buxue Tang (DBT, a herbal decoction that contains Astragali Radix (AR and Angelicae Sinensis Radix (ASR, we developed a model in analyzing the hydrolysis of flavonoid glycosides during the boiling of herbal mixture in water. A proper preparation of DBT is of great benefit to the complete extraction of bioactive ingredients. Boiling of DBT in water increased the solubility of AR-derived astragaloside IV, calycosin, formononetin, calycosin-7-O-β-D-glucoside, and ononin in a time- and temperature-dependent manner: the amounts of these chemicals reached a peak at 2 h. The glycosidic resides of AR, calycosin-7-O-β-D-glucoside, and ononin could be hydrolyzed during the moderate boiling process to form calycosin and formononetin, respectively. The hydrolysis efficiency was strongly affected by pH, temperature, and amount of herbs. Interestingly, the preheated herbs were not able to show this hydrolytic activity. The current results supported the rationality of ancient preparation of DBT in boiling water by moderate heat.

  10. A complexity analysis of Chinese herbal property theory:the multiple expressions of herbal property%复杂性科学视野下的中药药性理论——药性表达的多样性

    Institute of Scientific and Technical Information of China (English)

    金锐; 张冰

    2012-01-01

    中药药性是药物性质与功能的高度概括,反映了中药干预机体后的作用倾向.中药药性表达即中药药性的生物学表达,描述了将药性所蕴含的作用及功能信息表现在生物载体上的过程.由于药性表达涉及中药与机体两大复杂系统,故其具有复杂性特征.第一,药性表达的影响因素十分复杂,药材的生长环境、采收季节、炮制加工等,以及机体的体质、证候等,均可影响实际的药性表达结果;第二,鉴于药物个性特征,相同药性的不同中药会通过不同的药效作用(指标)表达药性,其药性表达方式多样.中药药性表达具有多样性特征,药性实质研究应密切关注影响药性表达的各因素.%Chinese herbal property is the highly summarized concept of herbal nature and pharmaceutical effect, which reflect the characteristics of herbal actions on human body. These herbal actions, also interpreted as presenting the information about pharmaceutical effect contained in herbal property on the biological carrier, are defined as herbal property expressions. However, the biological expression of herbal property is believed to possess complex features for the involved complexity of Chinese medicine and organism. Firstly, there are multiple factors which could influence the expression results of herbal property such as the growth environment, harvest season and preparing methods of medicinal herbs, and physique and syndrome of body. Secondly, there are multiple biological approaches and biochemical indicators for the expression of the same property. This paper elaborated these complexities for further understanding of herbal property. The individuality of herbs and expression factors should be well analyzed in the related studies.

  11. Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages.

    Science.gov (United States)

    Jeong, Soo-Jin; Kim, Ohn-Soon; Yoo, Sae-Rom; Seo, Chang-Seob; Kim, Yeji; Shin, Hyeun-Kyoo

    2016-05-01

    Gwakhyangjeonggi‑san (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, Pinellia ternata, Platycodon grandiflorum, Glycyrrhiza uralensis, Ziziphus jujuba and Zingiber officinale. GHJGS has been used for treating diarrhea‑predominant irritable bowel syndrome in traditional Korean medicine. In the present study, the anti‑inflammatory and antioxidant effects of GHJGS were investigated using the RAW 264.7 murine macrophage cell line. GHJGS significantly reduced production of the proinflammatory cytokines, tumor necrosis factor‑α, interleukin‑6 and prostaglandin E2 in lipopolysaccharide (LPS)‑stimulated macrophages. GHJGS markedly suppressed LPS‑induced phosphorylation of mitogen‑activated protein kinases, whereas it had no effect on nuclear factor‑κB activation. Furthermore, GHJGS enhanced expression of heme oxygenase‑1 and prevented the generation of reactive oxygen species in RAW 264.7 cells. These results indicate that GHJGS is a viable therapeutic agent against inflammation and oxidative stress‑associated disorders. PMID:27052497

  12. Traditional Korean Herbal Formula Samsoeum Attenuates Adipogenesis by Regulating the Phosphorylation of ERK1/2 in 3T3-L1 Cells

    Directory of Open Access Journals (Sweden)

    Soo-Jin Jeong

    2015-01-01

    Full Text Available Adipogenesis is the cell differentiation process from preadipocytes into adipocytes and the critical action in the development of obesity. In the present study, we conducted in vitro analyses to investigate the inhibitory effects of Samsoeum (SSE, a traditional herbal decoction. SSE had no significant cytotoxic effect against either the undifferentiated or differentiated 3T3-L1 cells. Oil Red O staining results showed that SSE significantly inhibited fat accumulation in adipocytes. SSE treatment consistently reduced the intracellular triglyceride content in the cells. SSE significantly inactivated glycerol-3-phosphate dehydrogenase (GPDH, a major link between carbohydrate and lipid metabolisms in 3T3-L1 adipocytes, and markedly inhibited the production of leptin, an important adipokine, in differentiated cells. SSE markedly suppressed the mRNA expression of the adipogenesis-related genes peroxisome proliferator-activated receptor-gamma (PPAR-γ, CCAAT/enhancer binding protein-alpha (C/EBP-α, fatty acid synthase (FAS, lipoprotein lipase (LPL, and fatty acid binding protein 4 (FABP4. Importantly, SSE increased the phosphorylation of ERK1/2, but not p38 MAPK and JNK, in adipose cells. Overall, our results indicate that SSE exerts antiadipogenic activity and modulates expressions of adipogenesis-related genes and ERK1/2 activation in adipocytes.

  13. Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis

    Science.gov (United States)

    Li, Yu; Ma, Hong; Lu, Ye; Tan, B. J.; Xu, L.; Lawal, Temitope O.; Mahady, Gail B.; Liu, Daniel

    2016-01-01

    The effect of Menoprogen (MPG) on ovarian granulosa cell (GC) apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old senile female rats for eight weeks increased plasma E2 levels, as well as the weight of both ovarian and uterine tissues. Flow cytometric (FCM) analysis of isolated GCs from MPG-treated aged rats showed reductions in the G0/G1 ratio and apoptotic peaks. Isolated GCs also exhibited an increase in cell size and the number of cytoplastic organelles and intracellular gap junctions, the reappearance of secretory granules, and a lack of apoptotic bodies as determined by TEM. Results from a TdT-mediated dUTP nick end-labeling (TUNEL) assay revealed a reduction in TUNEL-positive GCs after MPG treatment. Immunohistochemical analysis showed a downregulation of proapoptotic Bax proteins and an upregulation of antiapoptotic Bcl-2 proteins. The addition of MPG-medicated serum to the media of cultured GCs also reduced cadmium chloride-induced apoptosis and downregulated caspase-3 protein expression. This work demonstrates that Menoprogen inhibits GC apoptosis in aged female rats and thereby increases E2 production. This represents a novel mechanism of action for this herbal medicine in the treatment of menopausal symptoms. PMID:26981526

  14. Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis

    Directory of Open Access Journals (Sweden)

    Yu Li

    2016-01-01

    Full Text Available The effect of Menoprogen (MPG on ovarian granulosa cell (GC apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old senile female rats for eight weeks increased plasma E2 levels, as well as the weight of both ovarian and uterine tissues. Flow cytometric (FCM analysis of isolated GCs from MPG-treated aged rats showed reductions in the G0/G1 ratio and apoptotic peaks. Isolated GCs also exhibited an increase in cell size and the number of cytoplastic organelles and intracellular gap junctions, the reappearance of secretory granules, and a lack of apoptotic bodies as determined by TEM. Results from a TdT-mediated dUTP nick end-labeling (TUNEL assay revealed a reduction in TUNEL-positive GCs after MPG treatment. Immunohistochemical analysis showed a downregulation of proapoptotic Bax proteins and an upregulation of antiapoptotic Bcl-2 proteins. The addition of MPG-medicated serum to the media of cultured GCs also reduced cadmium chloride-induced apoptosis and downregulated caspase-3 protein expression. This work demonstrates that Menoprogen inhibits GC apoptosis in aged female rats and thereby increases E2 production. This represents a novel mechanism of action for this herbal medicine in the treatment of menopausal symptoms.

  15. A reappraisal of herbal medicinal products.

    Science.gov (United States)

    Edwards, Sarah; Da-Costa-Rocha, Ines; Lawrence, M Jayne; Cable, Colin; Heinrich, Michael

    Complementary and alternative medicine is increasingly popular, and encompasses a number of systems and therapies based on diverse theories and practices, such as homoeopathy, traditional herbalism, reiki, ayurvedic medicine and traditional Chinese medicine. While many are based on metaphysical concepts for which there is no sound evidence, for herbal medicines there is a rational, scientific basis and increasing clinical evidence. This article suggests herbal medicines should no longer be considered part of CAM, but instead sit alongside conventional medicines. PMID:23155905

  16. Prognostic abilities of different calculation formulas for the glomerular filtration rate in elderly Chinese patients with coronary artery disease

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    Fu S

    2013-02-01

    Full Text Available Shihui Fu, Yuan Liu, Bing Zhu, Tiehui Xiao, Shuangyan Yi, Yongyi Bai, Ping Ye, Leiming LuoDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of ChinaObjective: As a standard indicator of renal function, the glomerular filtration rate (GFR is vital for the prognostic analysis of elderly patients with coronary artery disease (CAD. Thus, the search for the calculation equation of GFR with the best prognostic ability is an important task. The most commonly used Modification of Diet in Renal Disease (MDRD equation and the Chinese version (CMDRD of the MDRD equation has many shortcomings. The newly developed Mayo Clinic quadratic (Mayo and Chronic Kidney Disease (CKD Epidemiology Collaboration (CKD-EPI equations may overcome these shortcomings. Because the populations involved in these equation-related studies are almost completely devoid of subjects > 70 years of age, there are more debates on the performance of these equations in the elderly. This study was designed to compare the prognostic abilities of different calculation formulas for the GFR in elderly Chinese patients with CAD.Methods: This study included 1050 patients (≥60 years of age with CAD. The endpoint was all-cause mortality over a mean follow-up period of 417 days.Results: The median age was 86 years (60–104 years. The median values for the MDRD-GFR, CMDRD-GFR, CKD-EPI-GFR, and Mayo-GFR were 66.0, 69.2, 65.6, and 75.8 mL/minute/1.73 m2, respectively. The prevalence of GFR < 60 mL/minute/1.73 m2 based on these measures was 39.3%, 35.4%, 43.0%, and 28.7%, respectively. Their area under the curve values for predicting death were 0.611, 0.610, 0.625, and 0.632, respectively. Their cut-off points for predicting death were 54.1, 53.5, 48.0, and 57.4 mL/minute/1.73 m2, respectively. Compared with the MDRD-GFR, the net reclassification improvement values of the CMDRD-GFR, CKD-EPI-GFR, and Mayo-GFR were 0.02, 0.10, and 0.14, respectively

  17. Study and Identification Method of Chinese Herbal Medicine in the Adjustment of Traditional Chinese Medicine%中药调剂中易混淆中药饮片鉴别方法分析研究

    Institute of Scientific and Technical Information of China (English)

    朱月健

    2015-01-01

    目的:探讨中药临床调剂中几种易混淆的鉴别方法。方法选取药用部位、加工方法、炮制工艺相同的植物加工品,同时保证其药品名称相似的饮片,查阅大量文献,并根据丰富的经验分析和鉴别这几种饮片。结果通过相关理论及经验可有效地鉴别中药饮片,避免调剂时发生混淆现象。结论对临床调剂易混淆的中药饮片进行有效的鉴别,可降低混淆的发生率,提升鉴别水平,为其鉴别提供依据。%Objective To investigate the methods of identifying the confusion in the clinical adjustment of chinese traditional medicine. Methods The medicinal parts,processing method and processing technology of the same plant processing products,and ensure that the drug name similar pieces,access to a large number of documents,and according to a wealth of experience analysis and identification of these pieces. Results Through the relevant theory and experience can effectively identify chinese herbal pieces,to avoid confusion when the phenomenon occurs. Conclusion The effective identification of chinese herbal medicine can reduce the incidence of confusion,improve the level of identification,and provide the basis for the identification.

  18. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.

    Directory of Open Access Journals (Sweden)

    Shaojing Li

    Full Text Available Recently, the pharmaceutical industry has shifted to pursuing combination therapies that comprise more than one active ingredient. Interestingly, combination therapies have been used for more than 2500 years in traditional Chinese medicine (TCM. Understanding optimal proportions and synergistic mechanisms of multi-component drugs are critical for developing novel strategies to combat complex diseases. A new multi-objective optimization algorithm based on least angle regression-partial least squares was proposed to construct the predictive model to evaluate the synergistic effect of the three components of a novel combination drug Yi-qi-jie-du formula (YJ, which came from clinical TCM prescription for the treatment of encephalopathy. Optimal proportion of the three components, ginsenosides (G, berberine (B and jasminoidin (J was determined via particle swarm optimum. Furthermore, the combination mechanisms were interpreted using PLS VIP and principal components analysis. The results showed that YJ had optimal proportion 3(G: 2(B: 0.5(J, and it yielded synergy in the treatment of rats impaired by middle cerebral artery occlusion induced focal cerebral ischemia. YJ with optimal proportion had good pharmacological effects on acute ischemic stroke. The mechanisms study demonstrated that the combination of G, B and J could exhibit the strongest synergistic effect. J might play an indispensable role in the formula, especially when combined with B for the acute stage of stroke. All these data in this study suggested that in the treatment of acute ischemic stroke, besides restoring blood supply and protecting easily damaged cells in the area of the ischemic penumbra as early as possible, we should pay more attention to the removal of the toxic metabolites at the same time. Mathematical system modeling may be an essential tool for the analysis of the complex pharmacological effects of multi-component drug. The powerful mathematical analysis method could

  19. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.

    Science.gov (United States)

    Li, Shaojing; Wu, Chuanhong; Chen, Jianxin; Lu, Peng; Chen, Chang; Fu, Meihong; Fang, Jing; Gao, Jian; Zhu, Li; Liang, Rixin; Shen, Xin; Yang, Hongjun

    2013-01-01

    Recently, the pharmaceutical industry has shifted to pursuing combination therapies that comprise more than one active ingredient. Interestingly, combination therapies have been used for more than 2500 years in traditional Chinese medicine (TCM). Understanding optimal proportions and synergistic mechanisms of multi-component drugs are critical for developing novel strategies to combat complex diseases. A new multi-objective optimization algorithm based on least angle regression-partial least squares was proposed to construct the predictive model to evaluate the synergistic effect of the three components of a novel combination drug Yi-qi-jie-du formula (YJ), which came from clinical TCM prescription for the treatment of encephalopathy. Optimal proportion of the three components, ginsenosides (G), berberine (B) and jasminoidin (J) was determined via particle swarm optimum. Furthermore, the combination mechanisms were interpreted using PLS VIP and principal components analysis. The results showed that YJ had optimal proportion 3(G): 2(B): 0.5(J), and it yielded synergy in the treatment of rats impaired by middle cerebral artery occlusion induced focal cerebral ischemia. YJ with optimal proportion had good pharmacological effects on acute ischemic stroke. The mechanisms study demonstrated that the combination of G, B and J could exhibit the strongest synergistic effect. J might play an indispensable role in the formula, especially when combined with B for the acute stage of stroke. All these data in this study suggested that in the treatment of acute ischemic stroke, besides restoring blood supply and protecting easily damaged cells in the area of the ischemic penumbra as early as possible, we should pay more attention to the removal of the toxic metabolites at the same time. Mathematical system modeling may be an essential tool for the analysis of the complex pharmacological effects of multi-component drug. The powerful mathematical analysis method could greatly

  20. Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

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    Xiuhui Li

    2014-01-01

    Full Text Available Background. This study was made to evaluate the efficacy of Chinese herbal medicines, Reduning injection, and a traditional Chinese medicine (TCM granule, in patients with severe hand, foot, and mouth disease (HFMD by conducting a prospective, controlled, and randomized trial. Methods. 355 severe HFMD patients were randomly assigned to receive conventional therapy alone, Reduning injection plus conventional therapy, or TCM enema plus conventional therapy for 7–10 days. Results. There was no significant difference in the incidence of major complications between the groups. Median time to fever clearance was 20 hours (95% CI: 6.0–25.0 for conventional therapy recipients, 18 hours (95% CI: 4.0–24.0 for Reduning combination-treated patients, and 6 hours (95% CI: 4.0–16.0 for TCM combination-treated patients. Only the difference in time to fever clearance between TCM combination group and conventional group reached statistical significance (P=0.048. Reduning combination group showed a significant reduction in sedative administration compared with conventional therapy group (P=0.008. No HFMD-related death and no important adverse events were observed. Conclusions. Reduning injection plus conventional therapy significantly reduced the concomitant use of sedatives, which may help decrease HFMD-related neurologic complications in children. TCM effectively reduced time to fever clearance and may become a complementary therapy for relieving the symptoms of severe HFMD.

  1. Concurrent Use of Hypnotic Drugs and Chinese Herbal Medicine Therapies among Taiwanese Adults with Insomnia Symptoms: A Population-Based Study

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    Kuei-Hua Lee

    2013-01-01

    Full Text Available Background. The increased practice of traditional Chinese medicine (TCM worldwide has raised concerns regarding herb-drug interactions. The purpose of our study is to analyze the concurrent use of Chinese herbal products (CHPs among Taiwanese insomnia patients taking hypnotic drugs. Methods. The usage, frequency of services, and CHP prescribed among 53,949 insomnia sufferers were evaluated from a random sample of 1 million beneficiaries in the National Health Insurance Research Database. A logistic regression method was used to identify the factors that were associated with the coprescription of a CHP and a hypnotic drug. Cox proportional hazards regressions were performed to calculate the hazard ratios (HRs of hip fracture between the two groups. Results. More than 1 of every 3 hypnotic users also used a CHP concurrently. Jia-Wei-Xiao-Yao-San (Augmented Rambling Powder and Suan-Zao-Ren-Tang (Zizyphus Combination were the 2 most commonly used CHPs that were coadministered with hypnotic drugs. The HR of hip fracture for hypnotic-drug users who used a CHP concurrently was 0.57-fold (95% CI = 0.47–0.69 that of hypnotic-drug users who did not use a CHP. Conclusion. Exploring potential CHP-drug interactions and integrating both healthcare approaches might be beneficial for the overall health and quality of life of insomnia sufferers.

  2. Chinese Herbal Decoction Based on Syndrome Differentiation as Maintenance Therapy in Patients with Extensive-Stage Small-Cell Lung Cancer: An Exploratory and Small Prospective Cohort Study

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    Rui Liu

    2015-01-01

    Full Text Available Objective. To investigate the treatment effect and treatment length of Chinese herbal decoction (CHD as maintenance therapy on patients with extensive-stage small-cell lung cancer (ES-SCLC and to reflect the real syndrome differentiation (Bian Zheng practices of traditional Chinese medicine (TCM. Patients and Methods. Different CHDs were prescribed for each patient based on syndrome differentiation. The length of CHD treatment was divided into two phases for analyzing progression-free survival (PFS and postprogression survival (PPS. Results. Three hundred and fifty-seven CHDs were prescribed based on syndrome differentiation during the study period. Median PFS was significantly longer in patients who received CHD >3 months than patients who received CHD ≤3 months in the first phase (8.7 months versus 4.5 months; hazard ratio (HR, 0.52; 95% confidence interval (CI, 0.41–0.99; P=0.0009. Median PPS was significantly longer in patients who received CHD >7 months than patients who received CHD ≤7 months in the second phase (11.7 months versus 5.1 months; HR, 2.32; 95% CI, 1.90–2.74; P=0.002. Conclusion. CHD could improve PFS and PPS, which are closely related to treatment time and deepness of response of first-line therapy. In addition, CHD could improve body function and keep patients in a relatively stable state.

  3. Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells

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    Chih-Jung Yao

    2011-01-01

    Full Text Available Tien-Hsien Liquid (THL is a Chinese herbal mixture that has been used worldwide as complementary treatment for cancer patients in the past decade. Recently, THL has been shown to induce apoptosis in various types of solid tumor cells in vitro. However, the underlying molecular mechanisms have not yet been well elucidated. In this study, we explored the effects of THL on acute promyelocytic leukemia (APL NB4 cells, which could be effectively treated by some traditional Chinese remedies containing arsenic trioxide. The results showed THL could induce G2/M arrest and apoptosis in NB4 cells. Accordingly, the decrease of cyclin A and B1 were observed in THL-treated cells. The THL-induced apoptosis was accompanied with caspase-3 activation and decrease of PML-RARα fusion protein. Moreover, DNA methyltransferase 1 and oncogenic signaling pathways such as Akt/mTOR, Stat3 and ERK were also down-regulated by THL. By using ethyl acetate extraction and silica gel chromatography, an active fraction of THL named as EAS5 was isolated. At about 0.5–1% of the dose of THL, EAS5 appeared to have most of THL-induced multiple molecular targeting effects in NB4 cells. Based on the findings of these multi-targeting effects, THL might be regarding as a complementary and alternative therapeutic agent for refractory APL.

  4. 中草药制剂对獭兔肠道内环境影响的研究%Study on the effects of the Chinese herbal medicine on the intestinal environment in rex rabbit

    Institute of Scientific and Technical Information of China (English)

    左晓磊; 赵德明; 韩爱云; 赵国先

    2016-01-01

    The experiment observes the effects of the Chinese herbal medicine on the intestinal environ⁃ment of rex rabbit. 120 rex rabbits were randomly divided into 6 groups, each group was 20 rab⁃bits. The rex rabbits were fed in the same feeding environment. Treatments involved the control groupⅠ(basal diet); Ⅱ(basal plus 4 mg/kg Diclazuril); Ⅲ(basal plus 0.5% Chinese-herb), Ⅳ(basal plus 1.0%Chinese-herb), Ⅴ(basal plus 1.5% Chinese-herb), Ⅵ(basal plus 2.0% Chinese-herb). 50 days later, determination on the intestinal environment index. The results were listed as follows:①The rate of diar⁃rhea of the chinese herbal medicine group were significantly lower than the control group. The Chinese herbal medicine contains a variety of natural antimicrobial substances, and has a good preventive effect on rex rabbit. ②The Chinese herbal medicine can promote gastrointestinal peristalsis and regulation of enzyme of rex rabbit. The Chinese herbal medicine has a good role in promoting of rex rabbit intesti⁃nal environment. ③The Chinese herbal medicine can inhibit the proliferation of harmful bacteria, such as E.coli, salmonella and staphylococcus aureus, and adjusts the lactobacillus metabolism of bacteria. The Chinese herbal medicine has promote intestinal micro ecological system stability of rex rabbit.%试验研究不同水平的纯中草药饲料添加剂对生长獭兔肠道内环境的影响。采用单因素分组设计,将120只生长獭兔随机分为6组,每组4个重复,每个重复5只,在同一饲养环境下进行饲喂。第Ⅰ组为基础对照组,饲喂基础日粮;第Ⅱ组为抗生素组,在基础日粮中添加4 mg/kg的地克珠利;第Ⅲ、Ⅳ、Ⅴ、Ⅵ组为中草药饲料添加组,在基础日粮中分别添加0.5%、1.0%、1.5%、2.0%体重的中草药制剂。50 d后测定獭兔肠道内环境指标。结果表明:①试验中添加中草药制剂组的腹泻率明显低于对照组,中草药制剂含有多种

  5. The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action.

    Science.gov (United States)

    Siu, Wing-Sum; Wong, Hing-Lok; Lau, Ching-Po; Shum, Wai-Ting; Wong, Chun-Wai; Gao, Si; Fung, Kwok-Pui; Lau, Clara Bik-San; Hung, Leung-Kim; Ko, Chun-Hay; Leung, Ping-Chung

    2013-04-01

    An innovative anti-osteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post-menopausal osteopenic women. This study aimed to investigate the efficacy of ELP against bone loss during physical inactivity or weightlessness. A hindlimb unloading tail-suspended rat model was used for studying the effects of ELP on bone mineral density (BMD) and bone micro-architecture. For in vitro mechanistic studies, rat mesenchymal stem cells (MSCs) and mouse macrophage cells (RAW264.7) were used for studying the effects of ELP on osteogenic/adipogenic differentiations and osteoclastogenesis, respectively. Our data illustrated that ELP had a significant preventive effect against bone loss induced by tail-suspension (TS) at day 28 (p bone micro-architecture. ELP could significantly promote the osteogenesis and suppress the adipogenesis (p bone loss induced by TS through the actions of enhancing osteogenesis, suppressing adipogenesis and osteoclastogenesis.

  6. Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity.

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    Cathy W C Bi

    Full Text Available Fo Shou San (FSS is an ancient herbal decoction comprised of Chuanxiong Rhizoma (CR; Chuanxiong and Angelicae Sinensis Radix (ASR; Danggui in a ratio of 2:3. Previous studies indicate that FSS promotes blood circulation and dissipates blood stasis, thus which is being used widely to treat vascular diseases. Here, we aim to determine the cellular mechanism for the vascular benefit of FSS. The treatment of FSS reversed homocysteine-induced impairment of acetylcholine (ACh-evoked endothelium-dependent relaxation in aortic rings, isolated from rats. Like radical oxygen species (ROS scavenger tempol, FSS attenuated homocysteine-stimulated ROS generation in cultured human umbilical vein endothelial cells (HUVECs, and it also stimulated the production of nitric oxide (NO as measured by fluorescence dye and biochemical assay. In addition, the phosphorylation levels of both Akt kinase and endothelial NO synthases (eNOS were markedly increased by FSS treatment, which was abolished by an Akt inhibitor triciribine. Likewise, triciribine reversed FSS-induced NO production in HUVECs. Finally, FSS elevated intracellular Ca(2+ levels in HUVECs, and the Ca(2+ chelator BAPTA-AM inhibited the FSS-stimulated eNOS phosphorylation. The present results show that this ancient herbal decoction benefits endothelial function through increased activity of Akt kinase and eNOS; this effect is causally via a rise of intracellular Ca(2+ and a reduction of ROS.

  7. Effect of the additive of Chinese herbal medicine on Growth Performance of Broilers%促生长型中草药添加剂在肉仔鸡生产中应用效果

    Institute of Scientific and Technical Information of China (English)

    王占红; 朱延旭; 张喜臣

    2012-01-01

    本试验的目的是验证中草药对提高肉仔鸡生产性能的可行性。试验结果表明,采用本试验所研制的中草药添加剂可使1日龄艾维茵肉仔鸡在45个饲养日内增重提高3.25%,死亡率为5.03%,料重比提高3.90%。%The main aim of the experiment was proved the feasibility of the Chinese herbal medicine on improvement production performance of broilers. The result indicated that the Chinese herbal medicine formulated by authors could improve gain weight for 3.25, and improve the ration of the feed and gain weight for 3.90% for one-day-old Avian during forty-five days.

  8. 甘肃省中草药生产现状及可持续发展对策%PRESENT SITUATION OF CHINESE HERBAL MEDICINE PRODUCTION AND SUSTAINABLE DEVELOPMENT STRATEGIES IN GANSU PROVINCE

    Institute of Scientific and Technical Information of China (English)

    韩多; 王海鹏; 汪玉萍; 陆桂芝

    2011-01-01

    该文概述了甘肃省气候资源、中草药生产现状、市场背景,结合现阶段生产中存在的问题有针对性地提出了可持续发展的对策,使甘肃中草药产业发展形成具有强大竞争力的现代产业,成为甘肃经济发展新的增长点.%This paper summarized the climate resource, present production situation and market background of Chinese herbal medicine in Cansu province, put forward the countermeasures of sustainable development combined with the present production problems, which would make the Cansu Chinese herbal medicine industry development become the modern industry with strong competitiveness and a new growth point of economic development in Cansu province.

  9. Systems-Pharmacology Dissection of Traditional Chinese Medicine Compound Saffron Formula Reveals Multi-scale Treatment Strategy for Cardiovascular Diseases.

    Science.gov (United States)

    Liu, Jianling; Mu, Jiexin; Zheng, Chunli; Chen, Xuetong; Guo, Zihu; Huang, Chao; Fu, Yingxue; Tian, Guihua; Shang, Hongcai; Wang, Yonghua

    2016-01-01

    Cardiovascular diseases (CVDs) have been regarding as "the world's first killer" of human beings in recent years owing to the striking morbidity and mortality, the involved molecular mechanisms are extremely complex and remain unclear. Traditional Chinese medicine (TCM) adheres to the aim of combating complex diseases from an integrative and holistic point of view, which has shown effectiveness in CVDs therapy. However, system-level understanding of such a mechanism of multi-scale treatment strategy for CVDs is still difficult. Here, we developed a system pharmacology approach with the purpose of revealing the underlying molecular mechanisms exemplified by a famous compound saffron formula (CSF) in treating CVDs. First, by systems ADME analysis combined with drug targeting process, 103 potential active components and their corresponding 219 direct targets were retrieved and some key interactions were further experimentally validated. Based on this, the network relationships among active components, targets and diseases were further built to uncover the pharmacological actions of the drug. Finally, a "CVDs pathway" consisted of several regulatory modules was incorporated to dissect the therapeutic effects of CSF in different pathological features-relevant biological processes. All this demonstrates CSF has multi-scale curative activity in regulating CVD-related biological processes, which provides a new potential way for modern medicine in the treatment of complex diseases. PMID:26813334

  10. Systems-Pharmacology Dissection of Traditional Chinese Medicine Compound Saffron Formula Reveals Multi-scale Treatment Strategy for Cardiovascular Diseases

    Science.gov (United States)

    Liu, Jianling; Mu, Jiexin; Zheng, Chunli; Chen, Xuetong; Guo, Zihu; Huang, Chao; Fu, Yingxue; Tian, Guihua; Shang, Hongcai; Wang, Yonghua

    2016-01-01

    Cardiovascular diseases (CVDs) have been regarding as “the world’s first killer” of human beings in recent years owing to the striking morbidity and mortality, the involved molecular mechanisms are extremely complex and remain unclear. Traditional Chinese medicine (TCM) adheres to the aim of combating complex diseases from an integrative and holistic point of view, which has shown effectiveness in CVDs therapy. However, system-level understanding of such a mechanism of multi-scale treatment strategy for CVDs is still difficult. Here, we developed a system pharmacology approach with the purpose of revealing the underlying molecular mechanisms exemplified by a famous compound saffron formula (CSF) in treating CVDs. First, by systems ADME analysis combined with drug targeting process, 103 potential active components and their corresponding 219 direct targets were retrieved and some key interactions were further experimentally validated. Based on this, the network relationships among active components, targets and diseases were further built to uncover the pharmacological actions of the drug. Finally, a “CVDs pathway” consisted of several regulatory modules was incorporated to dissect the therapeutic effects of CSF in different pathological features-relevant biological processes. All this demonstrates CSF has multi-scale curative activity in regulating CVD-related biological processes, which provides a new potential way for modern medicine in the treatment of complex diseases. PMID:26813334

  11. Characterization of the Principal Constituents of Danning Tablets, a Chinese Formula Consisting of Seven Herbs, by an UPLC-DAD-MS/MS Approach

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    Changsen Zhan

    2016-05-01

    Full Text Available Danning Tablets are a traditional Chinese formula showing broad clinical applications in hepatobiliary diseases and containing a diversity of bioactive chemicals. However, the chemical profiling of the formula, which serves as the material foundation of its efficacy, is really a big challenge as Danning Tablets consist of seven herbs from different origins. An ultra-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry (UPLC-DAD-ESI-MS/MS approach was developed to characterize the principal polyphenol constituents in the formula. As a result, a total of 32 constituents, including 14 anthraquinones and their glucosides, four anthrones, two naphthalene glycosides, two stilbenes and 10 flavonoids were identified based on their retention time, UV absorption and MS/MS fragmentation patterns. The sources of these compounds were also illustrated. Most of the bioactive anthraquinone derivatives were found in Rhei Radix et Rhizoma or Polygoni Cuspidati Rhizoma et Radix, which are the Emperor drugs in the formula for its clinic usage. These findings indicate the merit of using this integrated UPLC-DAD-ESI-MS/MS approach to rapidly illustrate the chemical foundation of complex formulas. The present study will facilitate the quality control of Danning Tablet formulas as well as the individual herbs.

  12. Application of chinese herbal medicine additive and probiotics in pig production%中草药添加剂和益生素在养猪生产上的应用

    Institute of Scientific and Technical Information of China (English)

    方桂友; 邱华玲; 董志岩

    2015-01-01

    益生素和中草药添加剂是高效、安全可靠、无毒副作用的新一代绿色添加剂,可作为抗生素的替代品,在养猪业上具有广阔的应用前景。文中论述益生素和中草药添加剂的作用机理、协同作用及使用时的注意问题,以期为益生素和中草药添加剂在养猪生产上的联合应用提供参考。%As substitutes of antibiotics, Chinese herbal medicine additive and probiotics is efficient, safe and reliable, non-toxic side effects of a new generation of green feed additives, has broad application prospects in pig industry. This paper discusses the action mechanism of Chinese herbal medicine additive and probiotics, synergy and The use of attention problems ,in order to provide refer-ence for the combined application of Chinese herbal medicine additive and probiotics in the pig production.

  13. Analysis of the adverse drug reaction of the Chinese herbal%活血化瘀中药的不良反应分析

    Institute of Scientific and Technical Information of China (English)

    白宇明; 魏国义

    2013-01-01

    目的 分析活血化瘀中药的不良反应发生情况,促进临床合理用药.方法 通过以中药“不良反应”为关键词,检索CHKD期刊全文数据中1998-2011年国内所有文献,查阅中药致不良反应文献的原文,并进行分析.结果 15种常用活血化瘀基本中药引起的12类不良反应及药源性疾病共计203例,其中累及系统主要为泌尿系统62例,呼吸系统47例,皮肤症状27例,急性中毒13例和循环系统12例.引起不良反应较多的药物为斑蝥(6种)、水蛭、丹参、马钱子(各5种),当归、川芎、乳香、三七(各3种).年龄越大,活血化瘀中草药不良反应构成比越高.女性活血化瘀中草药不良反应构成比较男性高.结论 活血化瘀中药不良反应分类繁多,临床表现多种多样,应引起医务人员和广大患者的重视.%Objective To analyze the adverse drug reaction of blood-activating and stasis-resoloing Chinese herbal medicine.And in order to promote the clinical reasonable using medicine.Methods "Adverse drug reaction" was as the key words,all literature of full text data the CHKD journal from 1998 to 2011 were retrieved,literature of adverse reactions caused by the original inspection Chinese medicine were checked.Results A total of 15 kinds of commonly used blood circulation Chinese medicine caused 12 adverse reactions and drug-induced disease was 203 cases,involving 62 cases of the urinary system,47 cases of the respiratory system,27 cases of skin symptoms,13 cases of acute poisoning and cyclesystem in 12 cases.Drugs to cause adverse reactions were cantharidin (6 species),leeches,Salvia,horse vomica (5),Angelica,Chuanxiong,frankincense,Panax (3).The older,the higher the ratio of adverse reactions of Chinese herbal medicine.The female had higher incidence than men.Conclusion Traditional Chinese medicine has adverse classification and diverse clinical manifestations.The medical staff and the majority of patients should pay more attention on

  14. Experiment of Chinese herbal jian li fang on anti-kinetic fatigue%中药健力方抗运动性疲劳的实验

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    李瑞文; 魏纯镭

    2005-01-01

    BACKGROUND: To tonify qi, benefit spleen and primary qi, strengthen tendons and bones and promote circulations in meridians and collaterals are the classical principles in Chinese medicine for anti-kinetic fatigue.OBJECTIVE: To observe the efficacy of compound Chinese herbal medicine on anti-kinetic fatigue.DESIGN: Randomized controlled experiment based on animals.SETTINGS: Animal Experimental Center of Wenzhou Normal University and Zhejiang College of Traditional Chinese Medicine.MATERIALS: The experiment was performed in Animal Experimental Center of Zhejiang College of Traditional Chinese Medicine from February to June 2001, in which, 80 ICR mice of either sex, body weighted(22±2) g and 40 SD male rats, body weighted(194±7) g were employed.ETHODS: ① Eighty mice were randomized into two groups, of which, 40 mice was gastric-infused with Chinese herbal fiang li fang(experimental group) and 40 mice was with physiological saline (the control) . After bred for 15 days, they were randomized into 3 groups for anti-fatigue experiment ( n = 15, swimming time), anti-hypoxia ability( n = 15) and determination of hemoglobin(n=10). ② Determination of testosterone: Forty rats were randomized into 4 groups, named the control with physiological saline infusion, herbal infusion group, exercise group, exercise-herbal infusion group. In herbal infusion group, the rats were infused once a day. In exercise group and exercise-herbal infusion group, the rats exercised once a day, swimming till being exhausted at the tolerance of 3% body weight at 28 ℃ of water temperature. After bred for 20 days, heart blood 2 mL was collected with chest opened and the serum was centrifuged and placed in refrigerator at 4 ℃. Minigamma 1275γ counter and VCS method were applied for determina tion.MAIN OUTCOME MEASURES: ① Determination of swimming time of mice in every group. ③ Time of anti-hypoxia. ③ Levels of hemoglobin and testosterone in rats.RESULTS: Forty rats and 80 mice were all

  15. 三种复方中药对鲫鱼肝脏抗氧化功能的影响%Effect of three kinds of Chinese herbal compounds on antioxidation capability of liver in Crucian carp

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    王瑞雪; 王荻; 李绍戊; 卢彤岩; 刘红柏

    2012-01-01

    In this study, the antioxidation capacity of liver in Crucian carp (one-year old) was investigated after feeding with three kinds of Chinese herbal compounds(they were numbered AB, CD and AH) continuously for 28 days. The control group was set at the same time. Two percents of fish body weight were fed at 20℃ every day during the experiment. Then the livers were sampled to detect the four anti-oxidative indexes including SOD, MDA, GSH-PX and T-AOC. The results showed that testing groups exhibited a significantly higher level of SOD activity while a lower level of MDA compared to control group. And there was a significant difference between the AB, CD groups and the control group (P<0.05). The GSH-PX activities were higher in the three testing groups compared to the control group, with a significant difference (P<0.05) between the AH, CD groups and the control group. The three kinds of Chinese herbal compounds could increase the total antioxidant capacity (T-AOC) obviously, especially in AB and CD groups. Based on the study results mentioned above, these three formula compounds could increase the liver anti-oxidative capacity in the Crucian carp, and CD group had the best effect.%采用三种复方中药(编号分别为AB、CD和AH)分别饲喂1龄鲫鱼28 d,同时设置空白对照组,以探讨所用方剂对鲫鱼肝脏中抗氧化功能的影响.试验期间水温20℃,每天按照体重的2.0%投喂制备的饲料.采集鲫鱼肝脏,检测超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)、总抗氧化能力(T-AOC)四个代表性抗氧化指标.结果表明,三种复方中药组SOD活性均显著高于对照组.MDA含量均低于对照组,其中AB、CD组与对照组差异显著(P<0.05).GSH-PX活性均高于对照组,其中AH、CD组与对照组差异显著(P<0.05).三种复方中药均能提高T-AOC,其中AB、CD组提高效果显著(P<0.05).所选的三种复方中药均对鲫鱼肝脏抗氧化能力有促进作用,其中CD组方效果最好.

  16. Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

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    Jian Li

    2012-01-01

    Full Text Available Current strategies for drug discovery have reached a bottleneck where the paradigm is generally “one gene, one drug, one disease.” However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases. Interestingly, traditional chinese medicine (TCM has been practicing holistic views for over 3,000 years, and its distinguished feature is using herbal formulas to treat diseases based on the unique pattern classification. Though TCM herbal formulas are acknowledged as a great source for drug discovery, no drug discovery strategies compatible with the multidimensional complexities of TCM herbal formulas have been developed. In this paper, we highlighted some novel paradigms in TCM-based network pharmacology and new drug discovery. A multiple compound drug can be discovered by merging herbal formula-based pharmacological networks with TCM pattern-based disease molecular networks. Herbal formulas would be a source for multiple compound drug candidates, and the TCM pattern in the disease would be an indication for a new drug.

  17. Constituents of the anti-asthma herbal formula ASHMITM synergistically inhibit IL-4 and IL-5secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro

    Institute of Scientific and Technical Information of China (English)

    Bolleddula Javaprakasam; Nan Yang; Ming-Chun Wen; Rong Wang; Joseph Goldfarb; Hugh Sampson; Xiu-Min Li

    2013-01-01

    OBJECITVE:Anti-asthma herbal medicine intervention (ASHMITM),a combination of three traditional Chinese medicinal herbs developed in our laboratory,has demonstrated efficacy in both mouse models of allergic asthma,and a double-blind placebo-controlled clinical trial in patients with asthma.This study was designed to determine if the anti-inflammatory effects of individual herbal constituents of ASHMITM exhibited synergy.METHODS:Effects of ASHMI and its components aqueous extracts of Lingzhi (Ganoderma lucidum),Kushen (Sophora flavescens) and Gancao (Glycyrrhiza uralensis),on Th2 cytokine secretion by murine memory Th2 cells (D10.G4.1) and eotaxin-1 secretion by human lung fibroblast (HLF-1) cells were determined by measuring levels in culture supernatants by enzymelinked immunosorbent assay.Potential synergistic effects were determined by computing interaction indices from concentration-effect curve parameters.RESULTS:Individual Lingzhi,Kushen and Gancao extracts and ASHMI (the combination of individual extracts) inhibited production of interleukin (IL)-4 and IL-5 by murine memory Th2 cells and eotaxin-1 production by HLF-1 cells.The mean 25%-inhibitory-concentration (IC25)values (mg/mL)forASHMI,Lingzhi,Kushen and Gancaofor IL-4 production were 30.9,79.4,123,and 64.6,respectively; for IL-5 production were 30.2,263,123.2 and 100,respectively;for eotaxin-1 were 13.2,16.2,30.2,and 25.1,respectively.The IC50values (mg/mL) for ASHMI,Lingzhi,Kushen and Gancao for IL-4 production were 158.5,239.9,446.7,and 281.8,respectively; for eotaxin-1 were 38.1,33.1,100,and 158.5,respectively.The interaction indices of ASHMI constituents at IC25 were 0.35 for IL-4,0.21 for IL-5 and 0.59 for eotaxin-1.The interaction indices at IC50 values were 0.50 for IL-4 and 0.62 for eotaxin-1 inhibition.Inhibition of IL-5 did not reach IC50 values.All interaction indices were below 1 which indicated synergy.CONCLUSION:By comparing the interaction index values,we find that constituents in

  18. Studies on Inhibitory Effect of 18 Kinds of Chinese Herbal Medicine on Escherichia coli%18种中草药对大肠杆菌抑菌效果的研究

    Institute of Scientific and Technical Information of China (English)

    赵鑫荟; 艾启俊

    2013-01-01

    [目的]研究鹿蹄草(WINTERGREEN)、功劳叶(CHINESE HOLLY LEAF)、金樱子(CHEROKEE ROSE FRUIT)和大黄(RHEUMOFFICINALE)等18种中草药提取物的抑菌作用.[方法]采用水煎法提取中草药的有效成分,以大肠杆菌作为供试菌,利用滤纸片法测定中草药提取物的抑菌作用,并用2倍稀释法测定抑菌效果最好的4种中草药的最小抑菌浓度.[结果]1s种中草药中有15种对大肠杆菌有抑制作用;其中鹿蹄草的最小抑菌浓度为31.25 mg/ml,功劳叶、金樱子和大黄的最小抑菌浓度均为62.50 mg/ml.[结论]鹿蹄草对大肠杆菌具有较好的抑制效果.%[Objective] The purpose was to investigate the inhibitory effects of 18 kinds of Chinese herbal medicine including WINTERGREEN, CHINESE HOLLY LEAF, CHEROKEE ROSE FRUIT, RHEUM OFFICINALE. [Method] Water decoction method was adopted to extract the active ingredients from Chinese herbal medicine, whose bacteriostatic effect was then determined by filter paper tablet method with Escherichia coli as the indicator bacteria. Double dilution method was used to determine the minimum inhibition concentrations of four kinds of Chinese herbal medicine, whose bacteriostatic effect was best. [ Result] Among the 18 kinds of Chinese herbal medicine, the extracts from 15 kinds of medicine had Inhibitory effect on Escherichia coli. The minimum inhibition concentration of Winlergreen was 31. 25 mg/ml and Chinese holly leaf, Cherokee rose fruit, rheum officinale was all 62.50 mg/ml. [Conclusion] The Wintergreen had a good inhibition effect to Escherichia coli.

  19. A Standardized Chinese Herbal Decoction, Kai-Xin-San, Restores Decreased Levels of Neurotransmitters and Neurotrophic Factors in the Brain of Chronic Stress-Induced Depressive Rats

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    Kevin Yue Zhu

    2012-01-01

    Full Text Available Kai-xin-san (KXS, a Chinese herbal decoction being prescribed by Sun Simiao in Beiji Qianjin Yaofang about 1400 years ago, contains Ginseng Radix et Rhizoma, Polygalae Radix, Acori tatarinowii Rhizoma, and Poria. KXS has been used to treat stress-related psychiatric disease with the symptoms of depression and forgetfulness in ancient China until today. However, the mechanism of its antidepression action is still unknown. Here, the chronic mild-stress-(CMS- induced depressive rats were applied in exploring the action mechanisms of KXS treatment. Daily intragastric administration of KXS for four weeks significantly alleviated the CMS-induced depressive symptoms displayed by enhanced sucrose consumption. In addition, the expressions of those molecular bio-markers relating to depression in rat brains were altered by the treatment of KXS. These KXS-regulated brain biomarkers included: (i the levels of dopamine, norepinephrine, and serotonin (ii the transcript levels of proteins relating to neurotransmitter metabolism; (iii the transcript levels of neurotrophic factors and their receptors. The results suggested that the anti-depressant-like action of KXS might be mediated by an increase of neurotransmitters and expression of neurotrophic factors and its corresponding receptors in the brain. Thus, KXS could serve as alternative medicine, or health food supplement, for patients suffering from depression.

  20. The Prescription Pattern of Chinese Herbal Products Containing Ginseng among Tamoxifen-Treated Female Breast Cancer Survivors in Taiwan: A Population-Based Study

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    Wei-Lung Hsu

    2015-01-01

    Full Text Available Background. The purpose of our study is to analyze the association between prescribed Chinese herbal products (CHPs containing Ginseng and the risk of endometrial cancer among tamoxifen (TMX users and to identify any possible interactive effects between Ginseng and TMX with respect to preventing the development of subsequent endometrial cancer in an estrogen-dependent breast cancer population in Taiwan. Methods. All patients newly diagnosed with invasive breast cancer receiving tamoxifen treatment from January 1, 1998, to December 31, 2008, were selected from the National Health Insurance Research Database. The usage, frequency of service, and CHP-Ginseng prescribed across the 30,556 TMX-treated breast cancer (BC survivors were evaluated. Logistic regression was employed to estimate the odds ratios (ORs for the utilization of CHP-Ginseng. Cox’s proportional hazard regression was performed to calculate the hazard ratios (HRs for endometrial cancer associated with Ginseng use among the TMX-treated BC cohort. Results. The HR for the development of endometrial cancer among breast cancer survivors who had ever taken Ginseng after TXM treatment was significantly decreased compared to those who never used CHP. Conclusion. A significant inhibitory relationship between Ginseng consumption and subsequent endometrial cancer less than 2 years after TMX treatment was detected among BC survivors.

  1. A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons

    Science.gov (United States)

    Yan, Lu; Hu, Qinghua; Mak, Marvin S. H.; Lou, Jianshu; Xu, Sherry L.; Bi, Cathy W. C.; Zhu, Yue; Wang, Huaiyou; Dong, Tina T. X.; Tsim, Karl W. K.

    2016-01-01

    Kai-Xin-San (KXS), a Chinese herbal decoction for anti-depression, is a combination of paired-herbs, i.e. Ginseng Radix et Rhizoma (GR)-Polygalae Radix (PR) and Acori Tatarinowii Rhizoma (ATR)-Poria (PO). The make-up of the paired-herbs has been commonly revised according to syndrome differentiation and treatment variation of individual. Currently, an optimized KXS (KXS2012) was prepared by functional screening different combination of GR-PR and ATR-PO. The aim of this study was to verify the effect and underlying mechanism of KXS2012 against depression in chronic mild stress (CMS)-induced depressive rats and in primary cultures of neurons and astrocytes. In rat model, the CMS-induced depressive symptoms were markedly alleviated by the treatment with KXS2012. The CMS-suppressed neurotransmitter amounts were restored in the presence of KXS2012. And the expressions of neurotropic factors and its corresponding receptors were increased under KXS2012 administration. In cultured neurons, application of KXS2012 could promote neurogenesis by inducing the expression of synaptotagmin and dendritic spine density. Moreover, application of KXS2012 in cultured astrocytes, or in H2O2-stressed astrocytes, induced the expressions of neurotrophic factors: the increase might be associated with the modification of Erk1/2 and CREB phosphorylation. Our current results fully support the therapeutic efficacy of KXS2012 against depression in cell and animal models. PMID:27444820

  2. Prescription profile of potentially aristolochic acid containing Chinese herbal products: an analysis of National Health Insurance data in Taiwan between 1997 and 2003

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    Lee Chang-Hsing

    2008-10-01

    Full Text Available Abstract Background Some Chinese herbal products (CHPs may contain aristolochic acid (AA or may be adulterated by the herbs suspected of containing AA which is nephrotoxic and carcinogenic. This study aims to identify the risk and the prescription profile of AA-containing CHPs (AA-CHPs in Taiwan. Methods A longitudinal analysis was conducted on a randomly sampled cohort of 200,000 patients using the data from the National Health Insurance (NHI in Taiwan between 1997 and 2003. Results During the 7-year study period, 78,644 patients were prescribed with AA-CHPs; most patients were females, or middle-aged, or both. A total of 526,867 prescriptions were made to use 1,218 licensed AA-CHPs. Over 85% of the AA-exposed patients took less than 60 g of AA-herbs; however, about 7% were exposed to a cumulated dose of over 100 g of Radix et Rhizoma Asari (Xixin, Caulis Akebiae (Mutong or Fructus Aristolochiae (Madouling. Patients of respiratory and musculoskeletal diseases received most of the AA-CHP prescriptions. The most frequently prescribed AA-CHPs Shujing Huoxie Tang, Chuanqiong Chadiao San and Longdan Xiegan Tang, containing Radix Stephaniae Tetrandrae, Radix et Rhizoma Asari and Caulis Akebiae, respectively. Conclusion About one-third of people in Taiwan have been prescribed with AA-CHPs between 1997 and 2003. Although the cumulated doses were not large, further actions should be carried out to ensure the safe use of AA-CHPs.

  3. Hepatoprotective effects of a Chinese herbal formulation, Yingchen decoction, on olaquindox-induced hepatopancreas injury in Jian carp (Cyprinus carpio var. Jian).

    Science.gov (United States)

    Zhou, Jishu; Li, Chao; Wang, Lihong; Ji, Hong; Zhu, Tianhe

    2015-02-01

    In order to identify effective hepatoprotective herbs for clinical application in fish farming, 200 mg/kg olaquindox (OLA) was added to a basal diet (group 1, control) to form OLA diet (group 2), then 1.35, 2.7 and 5.4 % (w/w) of a Chinese herbal formulation, Yingchen decoction (YCD), were added to the OLA diet to form three additional diets for groups 3, 4 and 5, respectively. A total of 375 juvenile Jian carp (Cyprinus carpio var. Jian) (52.12 ± 2.95 g/tail) were divided into five groups (triplicates per group) and fed the five diets mentioned above, respectively, for 6 weeks. At the termination of feeding experiment, serum biochemical indexes, viability of hepatocytes and the hepatopancreas microstructure for each group were detected and observed. The results showed that serum ALT and AST in group 2 were significantly higher than the control (P < 0.05). Plasma membranes hepatocyte nuclei in group 2 were found to be mostly indistinct, compared to group 1, and gradually recovered with the increasing supplementation of YCD in group 3, 4 and 5. The viability of isolated hepatocytes in group 2 was the lowest and gradually recovered with the increasing supplementation of YCD in group 3, 4 and 5. The results suggest that YCD protected the Jian carp hepatopancreas against injury from OLA, and that 5.4 % YCD would be the optimum dosage in a Jian carp diet. PMID:25477196

  4. Elimination of Cancer Stem-Like “Side Population” Cells in Hepatoma Cell Lines by Chinese Herbal Mixture “Tien-Hsien Liquid”

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    Chih-Jung Yao

    2012-01-01

    Full Text Available There are increasing pieces of evidence suggesting that the recurrence of cancer may result from a small subpopulation of cancer stem cells, which are resistant to the conventional chemotherapy and radiotherapy. We investigated the effects of Chinese herbal mixture Tien-Hsien Liquid (THL on the cancer stem-like side population (SP cells isolated from human hepatoma cells. After sorting and subsequent culture, the SP cells from Huh7 hepatoma cells appear to have higher clonogenicity and mRNA expressions of stemness genes such as SMO, ABCG2, CD133, β-catenin, and Oct-4 than those of non-SP cells. At dose of 2 mg/mL, THL reduced the proportion of SP cells in HepG2, Hep3B, and Huh7 cells from 1.33% to 0.49%, 1.55% to 0.43%, and 1.69% to 0.27%, respectively. The viability and colony formation of Huh7 SP cells were effectively suppressed by THL dose-dependently, accompanied with the inhibition of stemness genes, e.g., ABCG2, CD133, and SMO. The tumorigenicity of THL-treated Huh7 SP cells in NOD/SCID mice was also diminished. Moreover, combination with THL could synergize the effect of doxorubicin against Huh7 SP cells. Our data indicate that THL may act as a cancer stem cell targeting therapeutics and be regarded as complementary and integrative medicine in the treatment of hepatoma.

  5. Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats

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    Pengsong Liu

    2016-01-01

    Full Text Available Ischemia and hypoxia are important physiological changes in diabetic peripheral neuropathy (DPN. Chinese herbal medicine prescription Tangkuei Decoction for Frigid Extremities (TDFE is useful for increasing blood flow. To help determine whether TDFE could protect the peripheral nerves of diabetic patients from the degeneration caused by high blood glucose, TDFE was administered to streptozotocin-induced diabetic rats for 6 or 12 weeks. Plantar thermal stimulation reaction time thresholds, sciatic nerve conduction velocities, and the levels of HIF-1α mRNA, HIF-1α protein, VEGF protein, and the endothelial marker vWF in sciatic nerves were measured at the end of the sixth and twelfth weeks. The thermal thresholds and sciatic nerve conduction velocities of the rats differed after 12 weeks, and the sciatic nerves of the diabetic rats that were given TDFE displayed higher levels of HIF-1α protein, VEGF protein, and HIF-1α mRNA than those of the diabetic model rats. The results at 6 weeks differed from those at 12 weeks. These results suggest that the early preventive application of TDFE effectively delayed the development of DPN and that TDFE increased HIF-1α mRNA levels in the sciatic nerves of diabetic rats through 12 weeks of treatment.

  6. Effects of Danggui Buxue Tang, a traditional Chinese herbal decoction, on high glucose-induced proliferation and expression of extracellular matrix proteins in glomerular mesangial cells.

    Science.gov (United States)

    Ke, Hao-Liang; Zhang, Ying-Wen; Zhou, Bi-Fa; Zhen, Rui-Tang

    2012-01-01

    Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidney, but the efficacy of currently available strategies for the prevention of DN remains unsatisfactory. In this study, we investigated the effects of Danggui Buxue Tang (DBT), a Chinese herbal decoction prepared from Radix Astragali (RA) and Radix Angelicae sinensis (RAS), on high glucose-induced proliferation and expression of laminin, type IV collagen (collagen IV) and fibronectin in glomerular mesangial cells (GMCs). The cell proliferation was determined by MTT assay, and the expression of collagen IV, laminin and fibronectin in GMCs was detected by ELISA assay. It was shown that high glucose clearly induced the proliferation of GMCs and increased the release of collagen IV, laminin and fibronectin. Treatment with RA, RAS and DBT inhibited cell proliferation and the expression of collagen IV, laminin and fibronectin induced by high glucose, with DBT, especially at the highest concentration (DBT20), exhibiting a stronger effect than RA and RAS alone. Thus, it is concluded that DBT inhibits increased cell proliferation and the expression of major extracellular matrix proteins that are induced by high glucose, indicating its value for prophylaxis and therapy of DN at the early stages.

  7. 中草药营养去屑洗发香波的研制%Study on shampoo with nutrition and dandruff containing chinese herbal medicine

    Institute of Scientific and Technical Information of China (English)

    喻育红; 周进; 张玲

    2012-01-01

    The active components of Ganoderma lucidum and StepHania tetrandra.S.Moore, triterpenoids and tetrandrine, were extracted by microwave method and then were added into Shampoo. The influence of material dosage and experiment conditions on shampoo with nutrition and dandruff was investigated. The resulted shampoo containing Chinese herbal medicine in this paper was tested according to the trade criterion GB/T11432-89. It can be used safely and there is no stimulation on the skin. The performance of and-dandruff and relieving itching, nourishing and moisten hair, and decontamination was excellent.%选取中草药灵芝和汉防己,采用微波法提取其中的有效成份灵芝三萜和汉防已碱,并将其加入到洗发香波中,考察了原料用量与实验条件对中草药营养去屑洗发香波的影响.实验研制的中草药洗发香波其各项指标均符合国家标准洗发液GB/T11432-89的标准,使用安全,无刺激,有优良的去屑止痒、营养滋润和去污效果.

  8. Add-On Effect of Chinese Herbal Medicine on Mortality in Myocardial Infarction: Systematic Review and Meta-Analysis of Randomized Controlled Trials

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    Vincent C. H. Chung

    2013-01-01

    Full Text Available In China, Chinese herbal medicine (CHM is widely used as an adjunct to biomedicine (BM in treating myocardial infarction (MI. This meta-analysis of RCTs evaluated the efficacy of combined CHM-BM in the treatment of MI, compared to BM alone. Sixty-five RCTs (12,022 patients of moderate quality were identified. 6,036 patients were given CHM plus BM, and 5,986 patients used BM only. Combined results showed clear additional effect of CHM-BM treatment in reducing all-cause mortality (relative risk reduction (RRR = 37%, 95% CI = 28%–45%, I2=0.0% and mortality of cardiac origin (RRR = 39%, 95% CI = 22%–52%, I2=22.8. Benefits remained after random-effect trim and fill adjustment for publication bias (adjusted RRR for all-cause mortality = 29%, 95% CI = 16%–40%; adjusted RRR for cardiac death = 32%, 95% CI = 15%–46%. CHM is also found to be efficacious in lowering the risk of fatal and nonfatal cardiogenic shock, cardiac arrhythmia, myocardial reinfarction, heart failure, angina, and occurrence of total heart events. In conclusion, addition of CHM is very likely to be able to improve survival of MI patients who are already receiving BM. Further confirmatory evaluation via large blinded randomized trials is warranted.

  9. Chinese Herbal Medicine Treatment Improves the Overall Survival Rate of Individuals with Hypertension among Type 2 Diabetes Patients and Modulates In Vitro Smooth Muscle Cell Contractility.

    Directory of Open Access Journals (Sweden)

    Ying-Ju Lin

    Full Text Available Type 2 diabetes (T2D is a chronic, multifactorial, and metabolic disorder accounting for 90% diabetes cases worldwide. Among them, almost half of T2D have hypertension, which is responsible for cardiovascular disease, morbidity, and mortality in these patients. The Chinese herbal medicine (CHM prescription patterns of hypertension individuals among T2D patients have yet to be characterized. This study, therefore, aimed to determine their prescription patterns and evaluate the CHM effect. A cohort of one million randomly sampled cases from the National Health Insurance Research Database (NHIRD was used to investigate the overall survival rate of CHM users, and prescription patterns. After matching CHM and non-CHM users for age, gender and date of diagnosis of hypertension, 980 subjects for each group were selected. The CHM users were characterized with slightly longer duration time from diabetes to hypertension, and more cases for hyperlipidaemia. The cumulative survival probabilities were higher in CHM users than in non-CHM users. Among these top 12 herbs, Liu-Wei-Di-Huang-Wan, Jia-Wei-Xiao-Yao-San, Dan-Shen, and Ge-Gen were the most common herbs and inhibited in vitro smooth muscle cell contractility. Our study also provides a CHM comprehensive list that may be useful in future investigation of the safety and efficacy for individuals with hypertension among type 2 diabetes patients.

  10. Comparison of efficacy and toxicity of traditional Chinese medicine (TCM herbal mixture LQ and conventional chemotherapy on lung cancer metastasis and survival in mouse models.

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    Full Text Available Unlike Western medicine that generally uses purified compounds and aims to target a single molecule or pathway, traditional Chinese medicine (TCM compositions usually comprise multiple herbs and components that are necessary for efficacy. Despite the very long-time and wide-spread use of TCM, there are very few direct comparisons of TCM and standard cytotoxic chemotherapy. In the present report, we compared the efficacy of the TCM herbal mixture LQ against lung cancer in mouse models with doxorubicin (DOX and cyclophosphamide (CTX. LQ inhibited tumor size and weight measured directly as well as by fluorescent-protein imaging in subcutaneous, orthotopic, spontaneous experimental metastasis and angiogenesis mouse models of lung cancer. LQ was efficacious against primary and metastatic lung cancer without weight loss and organ toxicity. In contrast, CTX and DOX, although efficacious in the lung cancer models caused significant weight loss, and organ toxicity. LQ also had anti-angiogenic activity as observed in lung tumors growing in nestin-driven green fluorescent protein (ND-GFP transgenic nude mice, which selectively express GFP in nascent blood vessels. Survival of tumor-bearing mice was also prolonged by LQ, comparable to DOX. In vitro, lung cancer cells were killed by LQ as observed by time-lapse imaging, comparable to cisplatinum. LQ was more potent to induce cell death on cancer cell lines than normal cell lines unlike cytotoxic chemotherapy. The results indicate that LQ has non-toxic efficacy against metastatic lung cancer.

  11. 中草药和益生素对肉仔鸡生产性能影响的研究%The Application Research of Production Performance Effect of Chinese Herbal Medicine and Probiotics on Broilers

    Institute of Scientific and Technical Information of China (English)

    孙根成; 赵德明

    2012-01-01

    试验旨在研究中草药、益生素及其合剂对肉仔鸡生产性能的影响.选择3500只1日龄罗斯308肉仔鸡随机分为7组,每组设5个重复,每个重复100只鸡,对照组饲喂基础日粮,试验1、2、3、4、5组分别在基础日粮的基础上添加0.5%的药方1、药方2、益生素、中草药益生素合剂药方3、中草药益生素合剂药方4组;抗生素组为基础日粮中添加500 mg/kg杆菌肽锌.结果表明,中草药益生素合剂药方3组的体重、料重比、死淘率与对照组相比差异显著(P<0.05),与抗生素组相比差异不显著(P>0.05),优于其它处理组.因此,药方3促生长抗病效果较好,可以替代抗生素.%In order to explore the effect of Chinese herbal medicine, probiotics and its mixture on broiler production traits, the writer divided 3500 chickens into 7 groups randomly, including the blank control group, where broilers were fed on basic feedstuff, the antibiotics control group, where broilers were fed on basic feedstuff and 500 mg/kg bacitracin zinc,the Chinese herbal medicine group 1, the Chinese herbal medicine group 2, the probiotics group, the Chinese herbal medicine and probiotics mixture group 3, the Chinese herbal medicine and probiotics mixture group 4. All the five groups were fed on additional 0.5% their own variations and basic feedstuff. There were five repeats in each group. The results were as follows i compared with the control group, the Chinese herbal medicine and probiotics mixture group 3 had significant differences at the body weight, the feed conversion and the mortality elimination rate of broilers . However, there was no significant difference between group 3 and the antibiotics control group, but its effect was better than any other treatment group. The results indicated the Chinese herbal medicine and probiotics mixture group 3 had better effect on disease-resistant performance and growth promotion, thus, it could be used as a substitute for

  12. Coprescription of Chinese Herbal Medicine and Western Medications among Prostate Cancer Patients: A Population-Based Study in Taiwan

    Directory of Open Access Journals (Sweden)

    Yi-Hsien Lin

    2012-01-01

    Full Text Available Use of herbal medicine is popular among cancer patients. This study aimed to explore the coprescription of CHM and WM among prostate cancer patients in Taiwan. This cross-sectional retrospective study used a population-based database containing one million beneficiaries of National Health Insurance. Claims and prescriptions were analyzed. In 2007, 218 (22.4% prostate cancer patients were CHM users. Among CHM users, 200 (91.7% patients with 5618 (79.5% CHM prescriptions were on coprescription of CHM and WM. A total of 484 types of CHM and 930 types of WM were used. The most commonly used CHMs on coprescription were Shu Jing Huo Xue Tang, Ma Zi Ren Wan, and Xue Fu Zhu Yu Tang. The most commonly used WMs on coprescription were magnesium oxide, amlodipine, and aspirin. The average number of prescriptions per user per year was 261.2 versus 151.7 in all (P<0.001, 123.6 versus 76.9 in WM (P=0.033, and 34.8 versus 5.1 in CHM (P<0.001 for patients with and without coprescription, respectively. In conclusion, use of CHM among prostate cancer patients was popular in Taiwan. Most CHMs were used with WM concurrently. The potential drug-herb interactions should be investigated, especially for patients with more prescriptions.

  13. Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

    OpenAIRE

    Thomas Efferth; Marin, Jose J. G.; Stefan Kahl; Dorothea Kaufmann; Ashour, Mohamed L; Blazquez, Alba G; Romero, Marta R.; Michael Wink; Florian Herrmann

    2011-01-01

    In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)—a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei) and several cancer cell lines were identified. Six aqueous extracts...

  14. A theoretical and experimental study on the Fuzzy evaluation model of biological performance of Chinese materia medica with an either cold or hot herbal property%中药寒热药性表达模糊评价模式的理论与实验研究

    Institute of Scientific and Technical Information of China (English)

    金锐; 张冰; 刘小青; 薛春苗; 张倩; 李连珍; 赵茜; 李康

    2012-01-01

    OBJECTIVE: The concepts of cold and hot herbal properties in traditional Chinese medicine (TCM), reflecting the efficacy trends of medicinal herbs, have the Fuzzy characteristics. It is suited for the application of Fuzzy mathematics in research of herbal properties. For a comprehensive evaluation of herbal properties, this work constructed and made a practice of the Fuzzy discrimination model regarding the biological performance of Chinese materia medica.METHODS: Firstly, TCM formulas of cold or hot property were employed for setting the reference values and calculating the membership functions of cold and hot Fuzzy sets with Fisher discriminant. Then the model parameters of cold performance function (CPF) and hot performance function (HPF) were acquired. Second, the experimental data from studies on changes in multisystem indicators of animals given the classical cold formula (Sanhuang Fang) and hot formula (Jiangfugui Fang) were collected to calculate CPF and HPF. Then an experiment of administration of hot property herbs, Rougui (Cortex Cinnamomi) and Xianmao (Rhizoma Curculiginis), and cold property herbs, Huangbai (Cortex Phellodendri) and Zhizi (Fructus Gardeniae) to normal animals and animals with glucocorticoid-induced yang-deficiency or yin-deficiency state was designed. The relative changes in animal states were analyzed by the evaluation model to find the way in which herbal properties are represented.RESULTS: The HPF values of biological performance were higher than the CPF values in administration of Rougui to animals of normal (0. 528>0. 221), yang-deficiency (0. 203> -0. 490) and yin-deficiency (1.750 > -0.479) states, and in administration of Xianmao to animals of normal (0. 474> - 1. 601) and yang-deficiency (0. 288 > -1. 923) states, which represented the hot property. The HPF values of biological performance were lower than the CPF values in administration of Huangbai to animals of normal ( - 0. 870< 0.798) and yang-deficiency ( - 0.339<0. 194

  15. Efficacy and safety of Chinese herbal medicine for chronic prostatitis associated with damp-heat and blood-stasis syndromes: a meta-analysis and literature review

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    Wang Z

    2016-09-01

    Full Text Available Zhiqiang Wang,1 Lei Yuan,1 Yongchuan Wang,2 Baizhi Yang,1 Xiaohong Dong,1 Zhaowang Gao3 1Department of Urology, Shouguang Hospital of Traditional Chinese Medicine, Shouguang, 2Department of Urology, Weifang Traditional Chinese Hospital, Weifang, 3Department of Urology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Shandong, People’s Republic of China Objective: The aim of this meta-analysis and systematic review is to evaluate the safety and efficacy of Chinese herbal medicine (CHM for chronic prostatitis (CP associated with damp-heat and blood-stasis syndromes.Methods: An electronic search of 13 databases up to May 2016 was screened to identify randomized controlled trials comparing the safety and efficacy of CHM for the treatment of CP associated with damp-heat and blood-stasis syndromes. Studies reporting on effective rates, adverse events, National Institutes of Health chronic prostatitis symptom index (NIH-CPSI scores, and symptom index of Chinese medicine for chronic prostatitis (SI-CM scores as outcomes were included in the analysis. Data were analyzed by fixed- or random-effect models using the Review Manager software.Results: Thirteen articles with the modified Jadad score ≥4 were identified. It was found that CHM was superior to placebo in increasing the efficacy (odds ratio: 6.72, 95% confidence interval [CI]: 2.78–9.48, P<0.00001 and reducing the SI-CM scores (standardized mean difference: -1.08, 95% CI: -1.35 to -0.81, P<0.00001. Oral CHMs were significantly more effective than placebo at reducing NIH-CPSI scores, with a mean difference of -1.39 (95% CI: -1.87 to -0.92, P<0.00001. Nevertheless, no significant differences were found between Prostant and placebo (standardized mean difference: -0.23, 95% CI: -0.46 to 0.01, P=0.06. The frequency of adverse events associated with oral CHM was similar to that associated with placebo (risk ratio: 1.36, 95% CI: 0.72–2.55, P=0.34 and less than that

  16. Clinical research on navel application of Shehuang Paste combined with Chinese herbal colon dialysis in treatment of refractory cirrhotic ascites complicated with azotemia

    Institute of Scientific and Technical Information of China (English)

    Guang-Dong Tong; Da-Qiao Zhou; Jing-Song He; Lai Zhang; Zhi-Fei Chen; Chun-Ling Xiao; Li-Sheng Peng

    2006-01-01

    group (P > 0.05). The comprehensive treatment group's pre- and post-treatment portal vein and splenic vein blood flows showed a positive correlation to NO, ET-1 and endotoxin contents.CONCLUSION: When treating refractory cirrhotic ascites complicated with azotemia, Shehuang Paste combined with Chinese herbal dialysis is better than Shehuang Paste alone for ascites resolution, azotemia,and endotoxin elimination. However, both methods on their own were also effective for reducing portal and splenic vein blood flow, and lowering the contents of NO,ET-1 in the two treatment groups.

  17. Illustration of compositional variations over time of Chinese porcelain glazes combining micro-X-ray Fluorescence spectrometry, multivariate data analysis and Seger formulas

    Energy Technology Data Exchange (ETDEWEB)

    Van Pevenage, J., E-mail: Raman@UGent.be [Department of Analytical Chemistry, Raman Spectroscopy Research Group, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Verhaeven, E. [Department of Conservation and Restoration, University College Antwerp, Blindestraat 9, B-2000 Antwerp (Belgium); Vekemans, B. [Department of Analytical Chemistry, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Lauwers, D., E-mail: Raman@UGent.be [Department of Analytical Chemistry, Raman Spectroscopy Research Group, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Herremans, D.; De Clercq, W. [Department of Archaeology, Ghent University, Sint-Pietersnieuwstraat 35, B-9000 Ghent (Belgium); Vincze, L. [Department of Analytical Chemistry, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Moens, L., E-mail: Raman@UGent.be [Department of Analytical Chemistry, Raman Spectroscopy Research Group, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Vandenabeele, P. [Department of Archaeology, Ghent University, Sint-Pietersnieuwstraat 35, B-9000 Ghent (Belgium)

    2015-01-01

    In this research, the transparent glaze layers of Chinese porcelain samples were investigated. Depending on the production period, these samples can be divided into two groups: the samples of group A dating from the Kangxi period (1661–1722), and the samples of group B produced under emperor Qianlong (1735–1795). Due to the specific sample preparation method and the small spot size of the X-ray beam, investigation of the transparent glaze layers is enabled. Despite the many existing research papers about glaze investigations of ceramics and/or porcelain ware, this research reveals new insights into the glaze composition and structure of Chinese porcelain samples. In this paper it is demonstrated, using micro-X-ray Fluorescence (μ-XRF) spectrometry, multivariate data analysis and statistical analysis (Hotelling's T-Square test) that the transparent glaze layers of the samples of groups A and B are significantly different (95% confidence level). Calculation of the Seger formulas, enabled classification of the glazes. Combining all the information, the difference in composition of the Chinese porcelain glazes of the Kangxi period and the Qianlong period can be demonstrated. - Highlights: • Fully described methodology for the analysis of silicate glazes of Chinese porcelain samples • The combination of a semi-quantitative analysis of silicate glazes, multi-variate data and statistical analysis. • The use of Seger formula to understand better the composition of the glazes. • New insights into the glaze composition and structure of Chinese porcelain glazes of different time periods.

  18. Illustration of compositional variations over time of Chinese porcelain glazes combining micro-X-ray Fluorescence spectrometry, multivariate data analysis and Seger formulas

    International Nuclear Information System (INIS)

    In this research, the transparent glaze layers of Chinese porcelain samples were investigated. Depending on the production period, these samples can be divided into two groups: the samples of group A dating from the Kangxi period (1661–1722), and the samples of group B produced under emperor Qianlong (1735–1795). Due to the specific sample preparation method and the small spot size of the X-ray beam, investigation of the transparent glaze layers is enabled. Despite the many existing research papers about glaze investigations of ceramics and/or porcelain ware, this research reveals new insights into the glaze composition and structure of Chinese porcelain samples. In this paper it is demonstrated, using micro-X-ray Fluorescence (μ-XRF) spectrometry, multivariate data analysis and statistical analysis (Hotelling's T-Square test) that the transparent glaze layers of the samples of groups A and B are significantly different (95% confidence level). Calculation of the Seger formulas, enabled classification of the glazes. Combining all the information, the difference in composition of the Chinese porcelain glazes of the Kangxi period and the Qianlong period can be demonstrated. - Highlights: • Fully described methodology for the analysis of silicate glazes of Chinese porcelain samples • The combination of a semi-quantitative analysis of silicate glazes, multi-variate data and statistical analysis. • The use of Seger formula to understand better the composition of the glazes. • New insights into the glaze composition and structure of Chinese porcelain glazes of different time periods

  19. Chinese Herbal Medicine (Weijing Decoction Combined with Pharmacotherapy for the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

    Directory of Open Access Journals (Sweden)

    Shaonan Liu

    2014-01-01

    Full Text Available Objective. To evaluate the efficacy and safety of Weijing decoction combined with routine pharmacotherapy (RP for the treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD. Methods. Randomized controlled trials (RCT evaluating Weijing decoction for AECOPD were included. English, Chinese, and Japanese databases were searched from their respective inceptions to June 2013. The methodological quality was assessed according to the Cochrane Collaboration’s risk of bias tool. All data were analyzed and synthesized using RevMan 5.2 software. Results. Fifteen (15 studies involving 986 participants were included. Participants were diagnosed with COPD in the acute exacerbation stage. In addition, most of studies reported that they included participants with the Chinese medicine syndrome, phlegm-heat obstructing the Lung. Weijing decoction combined with RP improved lung function (forced expiratory volume in one second; FEV1, arterial blood gases (PaO2 and PaCO2, clinical effective rate, and reduced inflammatory biomarkers (TNF-α and IL-8 when compared with RP alone. No severe adverse events were reported in these studies. Conclusions. Weijing decoction appeared to be beneficial for AECOPD and well-tolerated when taken concurrently with RP, such as antibiotics, bronchodilators (oral and inhaled, and mucolytics.

  20. Research progress on current pharmacokinetic evaluation of Chinese herbal medicines%中草药新药多成分药代动力学评价的研究进展

    Institute of Scientific and Technical Information of China (English)

    黎国富; 赵浩如; 杨劲

    2011-01-01

    植物药在国外上市前必须经历药代动力学、生物利用度等一系列严格的科学研究以确证其安全性和有效性.美国FDA颁布了(植物药指导原则)以辅助申请者开发植物药,这对中草药新药研发也有极其重要的借鉴意义.该文对与FDA理念相一致的中草药药代动力学评价方法进行了综述和讨论,主要包括中草药中"药代动力学标记物"(PK markers)的鉴定、矩量法整合的多组分药代动力学研究、生物药剂学药物处置分类系统、群体药代动力学--药效动力学在中药-化药相互作用中的研究.%In order to prove safety and efficacy, herbal medicines must undergo the rigorous scientific researches such as pharmacokinetic and bioavailability, before they are put on the market in the foreign countries.Botanical Drug Products promulgated by the US FDA could guide industry sponsors to develop herbal drugs, which was also an important reference for investigating Chinese herbal medicines.This paper reviews and discusses novel approaches for how to assess systemic exposure and pharmacokinetic of Chinese herbal medicines, which were in line with FDA guidance.This mainly focus on identifying pharmacokinetic markets of botanical products, integral pharmacokinetic study of multiple components, Biopharmaceutics drug disposition classification system, and population pharmacokinetic-pharmacodynamic study in herb-drug interaction.

  1. Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

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    Hongmei Jia

    2013-01-01

    Full Text Available This study proposed a new strategy for uncovering the active chemical constituents of a traditional Chinese medicines (TCMs formula, Chaihu-Shu-Gan-San (CSGS. Metabonomics and chemical profile were integrated in combination with the multivariate statistical analysis (MVA to discover the chemical constituents which contribute to the antidepressant effect of CSGS. Based upon the difference between CSGS and QZ (CSGS without Zhi-Qiao extracts in the chemical profiles and the regulations of metabolic disturbances induced by CUMS, synephrine, naringin, hesperidin, and neohesperidin were recognized as the active constituents of CSGS from Zhi-qiao responsible for those missing regulations of CSGS when Zhi-Qiao was subtracted from the whole formula. They participated in the regulations of the deviated metabolites 2–4, 10–14, and 22–25, involved in metabolic pathways of ketone bodies synthesis, phenylalanine, tyrosine and tryptophan biosynthesis, valine, aspartate, glutamate metabolism, and glycolysis/gluconeogenesis. Furthermore, the assay of MAO-A activity confirmed the potential antidepressant effect of naringin and its active sites on the MAO-A was inferred by molecular docking study. The integration of metabonomics and chemical profile was proved to be a useful strategy for uncovering what the active chemical constituents in TCM formula are and how they make contributions for the efficacy of the formula.

  2. 骨关节炎的中药治疗现状%Current status of Chinese herbal therapy for osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    曹月龙; 庞坚; 王翔; 石瑛; 沈卫东; 郑昱新; 詹红生; 石印玉

    2006-01-01

    目的:通过证、法、方、药的写作顺序简述中医药治疗骨关节炎的近况.资料来源:应用计算机检索PUBMED 1966-10/2005-10期间的相关文章,检索词为"osteoarthritis,degenerative arthritis,traditional chinese medicine,chinese medieine,chinese botanical medicine,chinese phytotherapy",并限定文章语言种类为English.同时计算机检索万方数据库1979-10/2005-10期间的相关文章,检索词为"骨关节炎,退行性骨关节炎,中医,中国植物药,中国植物药疗法",并限定文章语言种类为中文.资料选择:对资料进行初审,并查看每篇文献后的引文.纳入标准:文章所述内容应与中医药治疗骨关节炎的研究相关.排除标准:重复研究或Meta分析类文章.资料提炼:共收集到284篇相关文献,98篇文献符合纳入标准,排除的186篇文献为内容陈旧或重复.符合纳入标准的98篇文献中,69篇涉及痹证类的病因病机、治法或方药近况,29篇涉及痿类的病因病机、治法或方药近况.本文选用其中的31篇作为资料综合:有学者将骨关节炎归为痹证范畴,相关治法有补肾法;健脾法;祛邪法(包括有祛风除湿法、散寒止痛法、活血祛瘀法、化痰软坚法、解毒散结法).另有学者将骨关节炎归为痿证范畴,治法有养血软坚法、养筋柔肝.大多数文献报道为自拟诊疗标准,缺乏统一公认的疗效评价标准;相对缺少按照循证医学要求进行的前瞻设计的随机、对照临床试验.在用药上,骨关节炎的治疗药物十分广泛,从常用药材至虫毒类药都有.从剂型和药物上对骨关节炎的治疗进行改革和筛选将是中医现代化的有益探索.结论:中医多从痹证或痿证的角度治疗骨关节炎,运用相应的祛邪、补肾、健脾、柔肝药及虫毒类药.目前相对缺少按照循证医学原则要求设计的随机、对照临床试验.

  3. A prescribed Chinese herbal medicine improves glucose profile and ameliorates oxidative stress in Goto-Kakisaki rats fed with high fat diet.

    Directory of Open Access Journals (Sweden)

    Lin Wu

    Full Text Available Oxidative stress (OS plays a role in hyperglycemia induced islet β cell dysfunction, however, studies on classic anti-oxidants didn't show positive results in treating diabetes. We previously demonstrated that the prescribed Chinese herbal medicine preparation "Qing Huo Yi Hao" (QHYH improved endothelial function in type 2 diabetic patients. QHYH protected endothelial cells from high glucose-induced damages by scavenging superoxide anion and reducing production of reactive oxygen species. Its active component protected C2C12 myotubes against palmitate-induced oxidative damage and mitochondrial dysfunction. In the present study, we investigated whether QHYH protected islet β cell function exacerbated by high fat diet (HFD in hyperglycemic GK rats. 4-week-old male rats were randomly divided into high HFD feeding group (n = 20 and chow diet feeding group (n = 10. Each gram of HFD contained 4.8 kcal of energy, 52% of which from fat. Rats on HFD were further divided into 2 groups given either QHYH (3 ml/Kg/d or saline through gastric tube. After intervention, serum glucose concentrations were monitored; IPGTTs were performed without anesthesia on 5 fasting rats randomly chosen from each group on week 4 and 16. Serum malondialdehyde (MDA concentrations and activities of serum antioxidant enzymes were measured on week 4 and 16. Islet β cell mass and OS marker staining was done by immunohistochemistry on week 16. QHYH prevented the exacerbation of hyperglycemia in HFD feeding GK rats for 12 weeks. On week 16, it improved the exacerbated glucose tolerance and prevented the further loss of islet β cell mass induced by HFD. QHYH markedly decreased serum MDA concentration, increased serum catalase (CAT and SOD activities on week 4. However, no differences of serum glucose concentration or OS were observed on week 16. We concluded that QHYH decreased hyperglycemia exacerbated by HFD in GK rats by improving β cell function partly via its

  4. Prevention of Canine Distemper in Dog with Chinese Herbal Medicine%中医药对犬瘟热的防制

    Institute of Scientific and Technical Information of China (English)

    胡小九; 李石友; 申时先; 施忠芬; 李秀枝

    2013-01-01

    In order to search a method to protect canine distemper of dog.The study of Chinese herbal medicine started at a cultivation farm in Kunming from April.2009 to Oct.2010,the results showed that all of sick dogs that got canine distemper was about 55.56% and 33.33%. most of them manifested symptoms of double-aspect fever,conjunctivitis,respiratory trachea inflammation,digestion disorder and neural symptom. The causes of why the dogs got this disease were relative to many factors, such as ages, immune status, sexes, environment and the seasons.And it can be used as reference for the prevention and cure of canine distemper.%2009年4月~2010年10月在昆明某养犬场进行中草药配方预防犬的犬瘟热的试验,结果表明,犬在未免疫状况下犬瘟热发病率为55.56%(5/9)和33.33%(3/9).中草药配方防犬瘟2号、3号对犬的犬瘟热疾病以及犬其它疾病有一定的预防作用,分别提高20.83%~33.33%和12.70%~ 18.06%.研究的中草药配方防犬瘟1号也对疫苗预防犬的犬瘟热疾病有较明显的加强效果,可提高33.33%.

  5. The Functional Study of a Chinese Herbal Compounded Antidepressant Medicine--Jie Yu Chu Fan Capsule on Chronic Unpredictable Mild Stress Mouse Model.

    Directory of Open Access Journals (Sweden)

    Lingling Ding

    Full Text Available Jie Yu Chu Fan capsule (JYCF is a new compounded Chinese herbal medicine for the treatment of depression. The present study was designed to explore the antidepressant effects and the possible mechanisms of JYCF by using chronic unpredictable mild stress (CUMS mouse model and comparing results to that of fluoxetine. Behavioral tests including an open field test, sucrose preference test and forced swim test were performed to evaluate the antidepressant effects of JYCF. The concentrations of monoamine neurotransmitters and metabolic products including norepinephrine (NE, 5-hydroxytryptamine (5-HT, dopamine (DA, 5-hydroxyindoleacetic acid (5-HIAA, homovanillic acid (HVA and 3,4-dihydroxyphenylacetic acid (DOPAC in the cerebral cortex and hippocampus of mice were determined by means of high performance liquid chromatography with electrochemical detection (HPLC-EC. The results show that a successful mouse CUMS model was established through 5 weeks of continuous unpredictable stimulation, as indicated by the significant decrease in sucrose preference and locomotor activity and increase in immobility time in the forced swim test. Chronic treatment of JYCF (1.25, 2.5 and 5 g/kg and fluoxetine (20 mg/kg significantly reversed the CUMS-induced behavioral abnormalities. JYCF (1.25, 2.5 and 5 g/kg significantly increased NE in CUMS mouse prefrontal cortex (P < 0.01, P < 0.01, P < 0.05 respectively and 5-HT in hippocampus (P < 0.05. In summary, our findings suggest that JYCF exerts comparable antidepressant-like effects to that of fluoxetine in CUMS mice. Besides, the antidepressant-like effect of JYCF is mediated by the increase of monoaminergic transmitters including 5-HT and NE.

  6. Ancient literature research on Chinese medicine formulae of diabetic nephropathy%基于古代文献的糖尿病肾病方药研究

    Institute of Scientific and Technical Information of China (English)

    张蕾; 刘旭生

    2012-01-01

    This research was to comb ancient Chinese medicine formulae on diabetic nephropathy by using Chinese Medical Tantras, and analyzing ancient literature. 87 ancient formulae were retrieved, which were recorded begin from the tang dynasty to the republic of China. Pill of Six Ingredients with Rehmannia, Shenqi-pill, Poria Alba Pill and Decoction of Four Drugs were recorded more frequency. However, only a handful of prescription has set up a file in the modern clinical application. It was discovered that two principles could help modem physicians using ancient formulae, that was syndrome differentiation and disease differentiation. But how to guide the clinical application of ancient formulae in modern clinic is still worth further explored.%本研究采用《中华医典》第四版为检索工具,通过检索糖尿病肾病相关古代文献,对其治疗方药进行梳理.共检索到方药87首,方药记载古籍年限起自唐朝止于民国.其中六味地黄丸、加减肾气丸、白茯苓丸、加减四物汤被记载引用较多.然而仅少数方药目前在临床推广应用.初步研究认为,现代医家可根据辨证论治和辨病论治两大原则应用古籍方药,但是如何让古籍方药更好的在现代临床应用仍值得进一步探究.

  7. Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae

    Directory of Open Access Journals (Sweden)

    Okamoto H

    2013-01-01

    Full Text Available Hideki Okamoto,1 Atsushi Chino,1 Yoshiro Hirasaki,1 Keigo Ueda,1 Masaomi Iyo,2 Takao Namiki11Department of Japanese-Oriental (Kampo Medicine, Chiba University Graduate School of Medicine, Chiba City, Japan; 2Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba City, Japan Background: Yokukan-san, a Japanese traditional herbal (Kampo prescription, has recently gathered increasing attention due to accumulating reports showing its remarkable efficacy in treating a wide variety of diseases refractory to conventional medicine as well as the behavioral and psychological symptoms of dementia. As yokukan-san has become broadly integrated with conventional medicine, augmentation therapy with other Kampo prescriptions has become necessary when the yokukan-san has been only partially efficacious. In this paper, we report three cases in which the addition of orengedoku-to, another Kampo formula, to yokukan-san was remarkably effective.Cases: Case 1 was an 85-year-old man with Alzheimer-type dementia who had become aggressive during the past 2 years. Three milligrams of aripiprazole completely suppressed his problematic behaviors but had to be stopped because of extrapyramidal symptoms. In the second case, a 44-year-old man with methamphetamine-induced psychosis had suffered from serious tardive dystonia for 2 years. No conventional approach had improved his tardive dystonia. The third case was a 29-year-old engineer who often failed to resist aggressive impulses and was diagnosed with intermittent explosive disorder. He was prescribed 5 mg of olanzapine, which did not suppress his extraordinary anger and caused somnolence even though the dose was low.Interventions and outcomes: Yokukan-san was complementarily added to the patients' regular medication and exerted a definitive but partial effect in all cases. The addition of orengedoku-to to yokukan-san exerted the same efficacy as aripiprazole in controlling aggressiveness in Case 1

  8. Studies on Drying Mathematic Model of Chinese Herbal Medicine and Parameter Analysis by Heat Transfer Theory%基于传热学原理研究中药材干燥数学模型及参数分析

    Institute of Scientific and Technical Information of China (English)

    熊耀坤; 何雁; 黄恺; 杜焰; 冯怡

    2012-01-01

    This study was aimed to establish the drying mathematical model of Chinese herbal medicine. The energy changes and influence factors were studied in the process of Chinese herbal medicine dried by thermodynamic theory. The Chinese herbal medicine drying mathematical model and analysis of the parameters ere established. The results showed that the existing drying research of Chinese herbal medicine is the summary of experienced knowledge. There is a big blindness in the choice of the drying method, process and equipment. We quantized the process of drying, and established Chinese herbal medicine drying mathematical model. The established parameters of the external environment are the heat conduction parameter C, the thermal radiation parameter D, and heat exchange parameters E. These parameters reflect the drying efficiency of the drying equipment. The established parameters of medicinal properties are the porosity Φ, specific heat Cp, herbs surface area S. These parameters reflect the herb drying capacity. It was concluded that the strengthening of basic theory study on Chinese herbal medicine drying will provide new methods and ideas for the reasonable selection of drying methods, processes and equipments. Therefore, the drying efficiency will be improved and the energy consumption will be reduced.%目的:建立中药材干燥数学模型,为优化干燥工艺提供理论依据.方法:运用传热学原理,探求中药材干燥过程中影响因数及能量变化过程,建立中药材干燥数学模型,并对参数进行分析.结果:现有中药材的干燥研究多为经验知识的总结,在干燥方法、工艺及设备的选择上存在很大的盲目性.本文量化了中药材干燥过程,建立起中药材干燥数学模型,建立起干燥条件参数:热传导参数C、热辐射参数D、为热交换参数E,用于评价干燥设备的干燥性能;建立起干燥物性参数:孔隙率椎、比热Cp、药材表面积S等,用于评价药材可干燥能力.

  9. 推拿配合中药熏蒸治疗陈旧性踝关节扭伤疗效观察%Efficacy observation of combining tuina and Chinese herbal fumigation for chronic ankle sprain

    Institute of Scientific and Technical Information of China (English)

    陈斌; 张峻峰; 李艳; 吴耀持

    2015-01-01

    目的:观察推拿配合中药熏蒸治疗陈旧性踝关节扭伤的临床疗效。方法:将纳入的93例患者根据随机数字表随机分为2组,观察组47例,给予经筋理论指导下推拿配合中药熏蒸治疗;对照组46例,予口服活血止痛药物配合中药熏蒸治疗。推拿和中药熏蒸均隔日1次,10次为1个疗程,治疗1个疗程后观察两组踝关节功能评分(Baird-Jackson)及临床疗效。结果:治疗后,除放射线检查结果外,两组治疗前后Baird-Jackson各项评分均有统计学差异(P<0.05,P<0.01);除踝关节活动度量(range of motion, ROM)外,两组间各项评分及总分差异亦有统计学意义(P<0.01)。观察组优良率为76.6%,对照组优良率为54.4%,两组优良率差异有统计学意义(P<0.05)。结论:经筋理论指导下推拿配合中药熏蒸治疗陈旧性踝关节扭伤的临床效果优于口服活血止痛药物配合中药熏蒸治疗。%Objective:To observe the clinical efficacy of combining tuina and Chinese herbal fumigation for chronic ankle sprain. Methods:A total of 93 cases were randomly allocated into an observation group (n=47) and a control group (n=46) according to the table of random number. Cases in the observation group received tuina combining with Chinese herbal fumigation, whereas cases in the control group received oral blood-circulating and pain-alleviating capsules combining with Chinese herbal fumigation. Both tuina and Chinese herbal fumigation were done once every other day and 10 times made up a course of treatment. The Baird-Jackson ankle scoring system and clinical efficacy were observed after 1 course of treatment. Results:After treatment, except for radiographic findings, there were significant intra-group differences in individual item scores of Baird-Jackson (P Conclusion:Combining Chinese herbal fumigation and tuina based on the muscle region theory can obtain better effect than combining oral blood-circulating and pain

  10. Screening of QHF formula for effective ingredients from Chinese herbs and its anti-hepatic cell cancer effect in combination with chemotherapy

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Background Recent studies have shown that effective ingredients of Chinese herbs are used more and more widely in the treatment or co-treatment of cancers,however,they are usually used separately and there has been limited research about joint application of Chinese herbs in multi-modal treatment.The aim of this study was to screen a QHF(Q:Qingrejiedu,H:Huoxuehuayu and F:Fuzhengguben)formula for effective ingredients from Chinese medicines and assess its anti-hepatic cell cancer(HCC)effect in combination with chemotherapy.Methods Six effective ingredients from Chinese medicine were selected based on the previous literature and used in the study.The QHF formula and the best ratio of ingredients were evaluated in H22 mouse(KM)models with solid tumors and ascites tumors by uniform design and monitoring inhibition of tumor growth and survival.We then observed the anti-hepatic cell cancer(HCC)effect of QHF when combined with cisplatin(DDP)in H22 mouse(Balb/c)models with solid tumors and ascites tumors.Evaluating of the therapeutic effect included the general condition of the mice,inhibition of tumor growth,survival,changes in body weight,thymus index,spleen index and WBC counts.Results The optimal QHF dose ratio for anti-hepatic cell cancer treatment was:800 mg/kg Cinobufotalin,14 mg/kg Ginsenosides Rg3,5.5 mg/kg PNS and 100 mg/kg Lentinan.Treatment was more efficient in inhibiting the growth of transplanted tumors in H22 mice when using the QHF formula(55.91%)than using Cinobufotalin(33.25%),Ginsenosides Rg3(35.11%),PNS(27.12%)or Lentinan(4.97%)separately.QHF also prolonged the life of H22 ascites hepatic cancer mice more efficiently(38.13%)than Cinobufotalin(25.00%),Ginsenosides Rg3(27.27%),PNS(23.30%) or Lentinan (24.43%).QHF combined with DDP could reduce DDP-induced leucopenia,spleen and thymus atrophy and other toxic reactions.Combining QHF with DDP the tumor growth inhibition reached 82.54% with a 66.83% increase in survival.Conclusions QHF is more efficient in

  11. Chinese Herbal Medicine for Improving Quality of Life Among Nonsmall Cell Lung Cancer Patients: Overview of Systematic Reviews and Network Meta-Analysis.

    Science.gov (United States)

    Wu, Xinyin; Chung, Vincent C H; Lu, Ping; Poon, Simon K; Hui, Edwin P; Lau, Alexander Y L; Balneaves, Lynda G; Wong, Samuel Y S; Wu, Justin C Y

    2016-01-01

    For patients with nonsmall cell lung cancer (NSCLC) receiving chemotherapy, current clinical evidence has indicated add-on benefit of Chinese herbal medicine (CHM) in improving quality of life (QoL). However, the relative performance among different CHM is unknown. The aim of this overview of systematic reviews (SRs) and network meta-analyses (NMA) is to evaluate the comparative effectiveness of different CHM. Seven electronic databases including both international databases and Chinese databases were searched. SRs focus on randomized controlled trials (RCTs) with comparison of CHM plus chemotherapy against chemotherapy alone on QoL among NSCLC patients were considered eligible. Data from RCTs were extracted for random effect pairwise meta-analyses. Pooled relative risk (RR) with 95% confidence interval (CI) was used to quantify the impact of CHM on QoL. NMA was used to explore the most effective CHM for improving QoL when used with chemotherapy. From 14 SRs, 61 RCTs (n = 4247) assessing 11 different CHM were included. Result from pairwise meta-analyses showed 6 CHM (Kang-lai-te injection, Shei-qi-fu-zheng injection, Compound ku-shen injection, Kang-ai injection, Zi-jin-long tablet, and Shen-fu injection) has significant beneficial effect on QoL among NSCLC patients when used with chemotherapy, even after adjustment for publication bias. Pooled RR varied from 1.38 (95% CI: 1.11-1.72, I2 = 0.0%, Kang-lai-te injection) to 3.36 (95% CI: 1.30-8.66, I2 = 0.0%, Zi-jin-long tablet). One trial comparing Hai-shen-su (a protein extract from Tegillarca granosa L.) plus chemotherapy with chemotherapy also demonstrated beneficial effect of combined treatment (RR = 3.13, 95% CI: 1.41-6.98). Results from NMA showed no differences on the comparative effectiveness among CHM, but Hai-shen-su plus chemotherapy has the highest probability (62.3%) of being the best option for improving QoL. Use of CHM on top of chemotherapy can significantly improve QoL in NSCLC patients. Although Hai

  12. Efficacy and safety of Chinese herbal medicine for chronic prostatitis associated with damp-heat and blood-stasis syndromes: a meta-analysis and literature review

    Science.gov (United States)

    Wang, Zhiqiang; Yuan, Lei; Wang, Yongchuan; Yang, Baizhi; Dong, Xiaohong; Gao, Zhaowang

    2016-01-01

    Objective The aim of this meta-analysis and systematic review is to evaluate the safety and efficacy of Chinese herbal medicine (CHM) for chronic prostatitis (CP) associated with damp-heat and blood-stasis syndromes. Methods An electronic search of 13 databases up to May 2016 was screened to identify randomized controlled trials comparing the safety and efficacy of CHM for the treatment of CP associated with damp-heat and blood-stasis syndromes. Studies reporting on effective rates, adverse events, National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) scores, and symptom index of Chinese medicine for chronic prostatitis (SI-CM) scores as outcomes were included in the analysis. Data were analyzed by fixed- or random-effect models using the Review Manager software. Results Thirteen articles with the modified Jadad score ≥4 were identified. It was found that CHM was superior to placebo in increasing the efficacy (odds ratio: 6.72, 95% confidence interval [CI]: 2.78–9.48, P<0.00001) and reducing the SI-CM scores (standardized mean difference: −1.08, 95% CI: −1.35 to −0.81, P<0.00001). Oral CHMs were significantly more effective than placebo at reducing NIH-CPSI scores, with a mean difference of −1.39 (95% CI: −1.87 to −0.92, P<0.00001). Nevertheless, no significant differences were found between Prostant and placebo (standardized mean difference: −0.23, 95% CI: −0.46 to 0.01, P=0.06). The frequency of adverse events associated with oral CHM was similar to that associated with placebo (risk ratio: 1.36, 95% CI: 0.72–2.55, P=0.34) and less than that associated with Prostant (risk ratio: 1.63, 95% CI: 1.14–2.34, P=0.008). Conclusion Our novel analysis demonstrates that CHM ranks highest in terms of improvement of CP associated with damp-heat and blood-stasis syndromes. While Prostant showed some efficacy in this disorder, it was associated with a smaller reduction in NIH-CPSI scores. In conclusion, CHM monotherapy is safe and

  13. Kidney-reinforcing Chinese herbal mixture promote the osseointegration of dental implant bone in vivo%补肾中药合剂促进牙种植体骨结合体内试验

    Institute of Scientific and Technical Information of China (English)

    陈国栋; 蔡嘉喜; 黄万仁; 梁淑霞; 胡超; 郭吕华

    2014-01-01

    Objective: Histopathological and Imageological method were used to assess osseointegration of dental implant after kidney-reinforcing chinese herbal mixture. Methods: 12 rabbits were divided into two groups at random, both at the top of the the tibial inserted implant pure titanium implant, a group kidney-reinforcing chinese herbal mixture were added to the feed, another group didn't join any drugs, after 30 days and 60 days put to death, with histopathologic evaluation of osseointegration of dental im-plant and bone tissue morphology metrology method. Results: The results of experimental pathology, bone tissue morphology metrology parameters and radiographic outcomes, were better than control group. Conclusion: Kidney-reinforcing chinese herbal mixture may promote osseointegration of dental implant.%目的:用组织病理学、影像学方法评估补肾中药合剂对牙种植骨结合的效果。方法:12只兔子随机分成二组,均在其胫骨顶端植入纯钛种植体,一组饲料中加入补肾中药合剂,另一组饲料中没加入任何药物,30天、60天后处死免子,分别用组织病理学及影像学方法评估种植体骨结合的情况。结果:试验组的病理学及影像学结果明显优于对照组;结论:补肾中药合剂能促进种植体骨结合。

  14. China's Formula,Go!

    Institute of Scientific and Technical Information of China (English)

    Li Yinghong; Yang Wei

    2009-01-01

    @@ On the first day of November,when Jenson Button cheered his first Formula I World Championship 2009 at the final race of the season in Abu Dhabi,Chinese young university students were busy preparing for their own Formula event.According to a press conference on October 19,2009 in Beijing,the first Formula SAE-China (FSAE) event has set off,and will be officially launch its final race next year from October 14 to October 17 at Shanghai International Circuit,where will also be the Formula 12010 China stop again in next April.

  15. 安徽省中药材出口贸易现状与发展对策--以亳州药材为例%Chinese Herbal Medicine Export Trade Situation and Development Strategy of Anhui Province:A Case Study of Bozhou Medicine

    Institute of Scientific and Technical Information of China (English)

    侯晶; 王萍; 侯博

    2014-01-01

    本文首先简要介绍了我国中药行业的出口现状,然后以安徽亳州为例,介绍安徽省中药材产业发展及出口情况,最后分析安徽省中药材出口贸易的优劣势,对中药出口存在的问题提出合理化建议。%This paper briefly describes the status of the export of Chinese herbal medicine industry, then by taking Bozhou in Anhui for example, describes the development and export of Chinese herbal medicine industry in Anhui Province, and finally analyzes the advantages and disadvantages of Anhui medicines export trade and proposes rational proposals for the problems of Chinese herbal medicine export.

  16. Observation of Therapeutic Effects of Two Traditional Chinese Herbal Medicines on Piglet' s Yellow- white Dysentery%两种中成药防治仔猪黄白痢的疗效观察

    Institute of Scientific and Technical Information of China (English)

    邢四仙; 张建乐

    2012-01-01

    采用中成药“母仔安”给分娩前3d、产仔后7~10d的母猪喂服、“仔痢宁”给已产黄白痢仔猪的母猪喂服3~5d,观察其发病率、病死率及双月仔猪成活率。试验结果表明:服用“母仔安”的产仔母猪所产仔猪发病率下降11.56%,病死率下降15.58%,双月成活率提高9.61%,非病死率下降1.1%;服用“仔痢宁”的母猪所产仔猪发病率下降6.9%,治愈率占发病数的88.9%,病死率下降18.93%,双月成活率提高8.72%,非病死率下降1.86%。%Piglet's yellow -white dysentery was an epidemic gastroenteritis caused by the pathogenic Escherichia coli with multiple serotypes in piglets induced by dysentery, high incidence, difficulty in cure, the high mortality. The test of feeding Muzian of traditional Chinese herbal medicine three days before delivery or 7 -10 days after farrowing and feeding Zilining of traditional Chinese herbal medicines for 3 - 5 days to sows was done to observe the incidence, mortality and survival rate of piglets bimonthly. The results showed that the incidence of piglet' s yellow - white dysentery after feeding Muzian of traditional Chinese herbal medicines to farrowing sows was seen down by | 1.56%, case fatality rate decreased by 15.58%, bimonthly survival rate increased by 9.61%, non - fatality rate decreased by 1.1%. The incidence of piglet' s yellow - white dysentery after feeding Zilining of traditional Chinese herbal medicines decreased by 6.9% , the cure rate of incidence number was 88.9% , case fatality rate decreased by 18.93% . bimonthly survival rate increased bv 8.72% , non -fatality rate decreased by 1.86%.

  17. Chinese Herbal Preparation Xuebijing Potently Inhibits Inflammasome Activation in Hepatocytes and Ameliorates Mouse Liver Ischemia-Reperfusion Injury.

    Directory of Open Access Journals (Sweden)

    Xiqiang Liu

    Full Text Available The Chinese herb preparation Xuebijing injection (XBJ has been widely used in the management of various septic disorders or inflammation-related conditions, however the molecular mechanism of its anti-inflammatory effect remains largely elusive. In the current study, we found that XBJ treatment potently ameliorated mouse hepatic ischemia-reperfusion (IR injury, manifested as decreased liver function tests (LDH, ALT, AST, improved inflammation and less hepatocyte apoptosis. Notably, XBJ markedly inhibited inflammasome activation and IL-1 production in mouse livers subjected to IRI, even in the absence of Kupffer cells, suggesting Kupffer cells are not necessary for hepatic inflammasome activation upon Redox-induced sterile inflammation. This finding led us to investigate the role of XBJ on hepatocyte apoptosis and inflammasome activation using an in vitro hydrogen peroxide (H2O2-triggered hepatocyte injury model. Our data clearly demonstrated that XBJ potently inhibited apoptosis, as well as caspase-1 cleavage and IL-1β production in a time- and dose-dependent manner in isolated hepatocytes, suggesting that in addition to its known modulatory effect on NF-κB-dependent inflammatory gene expression, it also has a direct impact on hepatocyte inflammasome activation. The current study not only deepens our understanding of how XBJ ameliorates inflammation and apoptosis, but also has immediate practical significance in many clinical situations such as partial hepatectomy, liver transplantation, etc.

  18. Effects of Chinese Herbal Medicine Combined with He-Ne Laser on Lipoperoxide and Superoxide Dismutase in Chloasma Patients

    Institute of Scientific and Technical Information of China (English)

    WU Yan-hua; LI Qi-lin; YANG Xiu-wen

    2009-01-01

    Objective:To observe the effects of Chinese decoction and ligustrazin hydrochloride injection combined with He-Ne laser on lipoperoxide (LPO) and Superoxide dismutase (SOD) in patients with chloasma.Methods:90 cases of chloasma were randomly divided into the following two groups:a treatment group (of 54 cases) treated by a self-prepared prescription for toning the kidneys and relieving the depressed liver to remove blood stasis, ligustrazin hydrochloricde injection and He-Ne laser therapy, and a control group (of 36 cases) treated with oral administration of Vitamin E and Vitamin C plus external application of 20% Azelaic acid cream.Results:The total effective rate in the treatment group was 79.6%, which was significantly higher than that of the control group (P<0.05).After treatment, the LPO level in the treatment group was significantly lowered (P<0.01), and the SOD level was significantly elevated (P<0.05).Conclusion:The therapeutic methods adopted in the treatment group may show the action of antioxidation, providing good clinical effects for treating chloasma.

  19. A study on standardization of dispensing procedure for small packages of Chinese herbal pieces%中药小包装饮片调剂操作流程规范化的研究

    Institute of Scientific and Technical Information of China (English)

    王陶丽; 刘玉芹; 刘灿坤

    2014-01-01

    Objective To establish a unified dispensing procedure for small packages of Chinese herbal pieces and to make it standardized so as to operate it easily, save time and energy, provide convenience for examination, avoid mistakes and eliminate medical disputes.MethodsA convenient and reliable, time and energy saving and scientific dispensing procedure was established according to the standardized dispensing procedure of Chinese herbal pieces, the features of small packages, and real working and operating experience.ResultsThe dispensing procedure for small packages of herbal pieces was different from that of Chinese herbal pieces in that its operational procedure and examination had unique functions. The main operational points included investigating, arranging, viewing, comparing, holding, weighing, allocating, examining, packaging, and dispatching. Conclusion Small packages of Chinese herbal pieces solve the problems of Chinese herbal pieces which are not easy to keep, allocate and maintain, as well as the problems during dispensing such as complicated weighing, uneven size, inaccurate weight, unfavorable condition for re-examination, messy environment and low quality; advantages such as one type of drug in one bag, easy identification, accurate weighing, easy check and exchange by name and drug, and informed consent for patients are ensured.%目的:制定统一中药小包装饮片的调剂操作流程,使其规范化、标准化、有利于操作,省时省力,便于审核,防止差错,杜绝医疗纠纷的发生。方法依据中药饮片的调剂规范流程,结合小包装饮片的特点,根据实际操作工作经验,制定便捷可靠、省时省力、科学操作的工艺流程。结果小包装饮片完全不同于中药饮片的调剂,其操作方法、审核等具有独特的操作性能,审、摆、看、对、拿、掂、分、核、包、发是其主要操作要点。结论中药小包装饮片解决了中药饮片不利于保管

  20. Effects of Chinese Herbal Medicine Prescriptions on Reproduction Performance of Transition Period Dairy Cows%复方中草药添加剂对围产期奶牛繁殖性能的影响

    Institute of Scientific and Technical Information of China (English)

    王煦; 宋元振

    2016-01-01

    The objective of study was to investigate the effects of Chinese herbal medicine additive on reproduction performance of perinatal dairy cows,and to provide theoretical basis and methods to exert the production performance of dairy cows. Totally 32 Chinese Holstein dairy cows with similar calving date,parity,milk production were randomly divided into 4 groups:control group,group A,group B,and group C.The control group fed diet,the experimental group added prescription Chinese herbal medicine from prenatal 21 days to postpartum 21days(total 42 days).The amount of Chinese herbal medicine added in Group A,Group B,and Group C is respectively 50g/d,100g/d,and 150g/d. The results show that The hormone secrection about cow's reproduction,ifrst estrus,during postpartum 70 day cows estrus ratio and calving interval were improved by adding Chinese herbal medicine to dietary during postpartum.It is indicate that the cows repreduction performance were improved by adding Chinese herbal medicine to dietary during postpartum.%本试验旨在探讨在基础日粮中添加复方中草药对围产期奶牛生殖激素的影响,以期为更好地发挥奶牛的遗传潜力提供理论依据。选用健康的围产期荷斯坦牛32头,按照年龄相近、胎次相近、预产期相近的原则,随机分成4组,对照组饲喂常规基础日粮,处理A组、处理B组、处理C组在基础日粮基础上添加复方中草药,从产前21d~产后21d连续饲喂42d,添加量分别为50g/d、100g/d、150g/d。结果表明:奶牛围产期日粮中添加复方中草药可促进围产期奶牛生殖激素的分泌,促进遗传潜力的发挥;奶牛围产期日粮中添加复方中草药可提高第一情期受胎率、产后70d内第一次发情的母牛比率,缩短分娩至产后第一次配种间隔天数和产犊间隔,促进奶牛产后体况恢复,提高奶牛的繁殖性能。

  1. 中药材扑克牌式趣味学习卡的设计与应用%Design and Application of Poker-like Funny Learning Card for Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    黄小方; 欧阳辉; 傅国强; 曾鸿鹄; 敖梅英

    2012-01-01

    目的:为提高中医药教学水平提供借鉴.方法:通过品种选编、图片采集、知识整理、样品制作等,设计制作扑克牌式学习卡,将常用中药材的实物彩图与知识要点印制成扑克牌形式的趣味学习卡,作为《中药材》等课程教学用品,并在《中药材》课堂进行应用与测评.结果:学习卡共设计5辑,每辑含4副扑克牌式学习卡,分别为原植物彩图、药材彩图、中文知识要点、英文知识要点.初样在实际教学应用中效果较好,通过扑克游戏和趣味记忆让学生掌握知识.结论:中药材扑克牌式趣味学习卡设计美观大方,简便易用,知识性与趣味性强,寓教于乐,能有效地促进教学效果,是教学良好的辅助工具,在中医药教学中具有开创性和启发性.%OBJECTIVE: To provide reference for improving teaching level of Chinese Herbal Medicine. Poker-like funny learning cards printed with pictures and knowledge tips of common used can be applied as study facilities, it is designed and applied to enhance learning enthusiasm of students. METHODS: Design process included species selection, picture collection, knowledge tips compilation, learning card samples preparation and so on. The color graph and knowledge point of Chinese herbal medicine were made into poker-like funny learning card as realia of course of Chinese Herbal Medicine. The learning card was applied and tested in the class of Chinese Herbal Medicine. RESULTS: There were 5 series of learning cards, each series contained 4 pokers: the original plant color graph, medicinal materials color graph, Chinese knowledge points, English knowledge points. The applied samples achieved good effect in the teaching practice, and students can master the knowledge easily with poker games and interesting memory methods. CONCLUSIONS: The design of poker-like funny learning card for Chinese Herbal Medicine is artistic, graceful, concise and convenient. The cards are full of

  2. 根类中草药净洗中引进超声波清洗技术的探讨%The Root of Chinese Herbal Medicine Wash Clean Introduction Ultrasonic Cleaning Technology is Discussed

    Institute of Scientific and Technical Information of China (English)

    刘淑梅; 陈军

    2012-01-01

    超声波清洗技术因其不受清洗件表面复杂形状的限制,清洗时间快、效果好和无污染等特点,而被广泛应用于清洁度要求高的器件清洗.将超声波清洗技术引入根生中药材泥土的净洗,选用适当的频率、功率、掌握恰当的时间,能起到节水环保、快速洗涤,杀死虫卵、抑制病毒和细菌、防止中草药贮藏虫蛀现象,并降低劳动强度的作用;经超声波技术清洗中药材加工成的饮片有利于有效成分的析出,有望提高中药成分利用率.%Ultrasonic cleaning technology because its not be cleaning a surface of a complex shape limit,cleaning time fast,good effect and no pollution,etc,and is widely used in high cleanliness requirements of the device to clean.Will ultrasonic cleaning technology into the root of Chinese life soil purify,choose the proper frequency and power,to master the appropriate time,can play the water saving,environmental protection,rapid washing,kill eggs and inhibit viruses and bacteria,prevent Chinese herbal medicine storage bug eat by moth phenomenon,and reduce the labor intensity role;By ultrasonic cleaning technology of Chinese herbal medicine processed into slices of effective ingredients for separation,is expected to improve the utilization rate of traditional Chinese medicine composition.

  3. Influence of Chinese Herbal Medicine on Monopterus albus Sex Hormone Secretion%中草药在促进黄鳝性腺发育中的应用前景

    Institute of Scientific and Technical Information of China (English)

    赵庆凯; 邴旭文; 丁炜东

    2014-01-01

    黄鳝的人工繁殖在我国的很多地方均已获得成功,黄鳝苗种的获得已成为制约黄鳝养殖业发展的主要因素。由于黄鳝的性逆转化、怀卵量低、性腺成熟不同步等特点,使人工繁殖难以取得历史性的突破。主要论述中草药在促进黄鳝性腺发育中的应用前景,利用中草药对亲鳝进行催熟催产,以实现鳝苗的大规模繁殖。%Artificial breeding of Monopterus in many parts of our country have been successful. However,Monopterus fry acquisition has become one of the main factors that restrict the devel-opment of Monopterus aquaculture.Due to the inverse transformation of Monopterus,its small number of eggs and the unsynchronization of sexual maturity,artificial breeding is difficult to a-chieve a historic breakthrough.This paper mainly discusses the application prospect of Chinese herbal medicine for Monopterus and the use of Chinese herbal medicine for its ripening oxytocin, so as to realize the large-scale eel seedling breeding.

  4. 医用乳酸菌对常用中草药的耐药性试验%Drug resistance test of medicinal lactic acid bacteria to common Chinese herbal medicines

    Institute of Scientific and Technical Information of China (English)

    王世荣; 杨丙田; 宋青楠; 王延秋; 王霞

    2013-01-01

    目的 研究医用乳酸菌对几种常用中草药的耐药性,为医用乳酸菌与中草药的临床合并应用提供理论依据.方法 将中草药制成煎剂,通过琼脂扩散方法进行耐药性试验.结果 5种医用乳酸菌对黄连均表现出中度敏感,对黄芩表现微弱敏感.结论 5种医用乳酸菌对大部分中草药(包括有抗菌和抑菌作用的中草药)不敏感.%Objective To study (he drug resistance of medicinal lactic acid bacteria to several common Chinese herbal medicines, and provide theoretical basis for clinical application of the combinations of herbs and lactic acid bacteria. Methods Drug resistance was detected by using agar diffusion test. Results The five kinds of medicinal lactic acid bacteria were all moderately sensitive to Rhizoma Coptidis and slightly sensitive to Scutellaria Baicalensis. Conclusion The five kinds of medicinal lactic acid bacteria are not sensitive to most Chinese herbal medicines including the herbs with have antimicrobial effect and antibacterial effects.

  5. 几味常用中药材非药用部位或混淆品入药现象分析%Analysis of Non-medicinal Parts and Adulterant of Chinese Herbal Medicine Used as Medicine

    Institute of Scientific and Technical Information of China (English)

    李勇

    2014-01-01

    OBJECTIVE:To analyze the phenomenon of non-medicinal parts and adulterant of Chinese herbal medicine used as medicine.METHODS:The property,physicochemical property and pesticide effects were indentified in authentic and fake Uncaria tomentosa,Polygala tenuifolia,Cryptotympana pustulata,Rubia cordifolia and the thorn of Gleditsia sinensis.RESULTS:Pesticide effects of non-medicinal parts were worse than authentic medicine or opposite to authentic medicine,and adulterant had no pesticide effects even had toxic effects.CONCLUSIONS:Non-medicinal parts and adulterant has a severe impact on pesticide effects of Chinese herbal medicine.%目的:防止中药材非药用部位或混淆品入药.方法:对钩藤、远志、蝉蜕、茜草、皂荚刺的正伪品性状、理化性状及药效进行鉴别.结果:非药用部位的药效差于正品或者药效相反,混淆品一般无药用价值甚至有毒副作用.结论:非药用部位或混淆品入药会严重影响中药的药效,甚至危害患者.

  6. 14种中草药对常见畜禽病原菌的体外抗菌研究%Bacteriostatic Test in vitro of 14 Chinese Herbal Medicines Against Common Pathogenic Bacteria of Livestock and Poultry

    Institute of Scientific and Technical Information of China (English)

    王伟; 魏磊; 王学方; 李晓; 董建军

    2015-01-01

    To study the effects of antibacterial activity of Chinese herbal medicine extracts ,the antibacterial activity of 14 Chinese herbal medicines to Escherichia coli,Staphylococcus aureu,Streptococcus pyogenes,Salmonella typhimurium, Streptococcus pneumonia,chicken Escherichia coli,chicken Staphylococcus aureu,Salmonella pullorum and Staphylococcus agalactiae was tested by filtering paper method and microdilution method. The extracts of honeysuckle flower ,fructus forsythiae,radix scutellar,rhizoma coptidis and cortex phellodendri chinensis have effective antibacterial activity.%为研究中草药提取物对畜禽常见病原菌的抑制作用,采用微量二倍稀释法和滤纸片法测定了14种中草药提取物对大肠杆菌、金黄色葡萄球菌、化脓性链球菌、鼠伤寒沙门氏菌、肺炎链球菌、鸡大肠杆菌、鸡金黄色葡萄球菌、鸡白痢沙门氏菌和牛无乳链球菌的抑制作用。结果表明:金银花、连翘、黄芩、黄连和黄檗具有良好的抗菌活性。

  7. 中草药抗乙型肝炎病毒的实验研究概况%A Review on Experimental Studies of Counteracting Hepatitis B Virus by Chinese Herbal Drugs

    Institute of Scientific and Technical Information of China (English)

    王伯祥

    2001-01-01

    为了客观考核各种药物的抗肝炎病毒的效果,多年来医学界用许多方法对中草药进行筛选,发现一些药物对HBsAg有抑制作用。在研究程序上,从体外到体内,从动物实验到人体治疗,从广泛筛选到重点研究,均取得了一系列成果。%Over the years, the Chinese herbal drugs have been screened to assess the effect of counteracting hepatitis B virus objectively, and the results indicated that some Chinese herbal drugs can inhibit HBsAg. The research procedure was going on from in-vitro to invivo, from animal to human body and from extensive screening to focal study, and a series of achievements was obtained.

  8. [Cloud Point extraction for determination of mercury in Chinese herbal medicine by hydride generation atomic fluorescence spectrometry with optimization using Box-Behnken design].

    Science.gov (United States)

    Wang, Mei; Li, Shan; Zhou, Jian-dong; Xu, Ying; Long, Jun-biao; Yang, Bing-yi

    2014-08-01

    Cloud point extraction (CPE) is proposed as a pre-concentration procedure for the determination of Hg in Chinese herbal medicine samples by hydride generation-atomic fluorescence spectrometry (HG-AFS). Hg2+ was reacted with dithizone to form hydrophobic chelate under the condition of pH. Using Triton X-114, as surfactant, chelate was quantitatively extracted into small volume of the surfactant-rich phase by heating the solution in a water bath for 15 min and centrifuging. Four variables including pH, dithizone concentration, Triton X-114 concentration and equilibrium temperature (T) showed the significant effect on extraction efficiency of total Hg evaluated by single-factor experiment, and Box-Behnken design and response surface method- ology were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum extraction efficiency. The results showed that the binomial was used to fit the response to experimental levels of each variable. ALL linear, quadratic terms of four variables, and interactions between pH and Trion X-114, pH and di- thizone affected the response value(extraction efficiency) significantly at 5% level. The optimum extraction conditions were as follows: pH 5.1, Triton X-114 concentration of 1.16 g x L(-1), dithizone concentration of 4.87 mol x L(-1), and T 58.2 degrees C, the predicted value of fluorescence was 4528.74 under the optimum conditions, and the experimental value had only 2.1% difference with it. Under the conditions, fluorescence was linear to mercury concentration in the range of 1-5 microg x L(-1). The limit of detection obtained was 0.01247 microg x L(-1) with the relative standard deviations (R.S.D.) for six replicate determinations of 1.30%. The proposed method was successfully applied to determination of Hg in morindae Radix, Andrographitis and dried tangerine samples with the recoveries of 95.0%-100.0%. Apparently Box-Behnken design combined with

  9. Clinical effect of Chinese herbal medicine Jiaweisimiaowan on gout%中药四妙丸加味治疗痛风的临床观察

    Institute of Scientific and Technical Information of China (English)

    宁波; 王新宴; 王文清

    2008-01-01

    目的 探讨痛风及高尿酸血症患者的异同及四妙丸加味治疗痛风的机制.方法 观察30例缓解期痛风患者、32例高尿酸血症患者和31名健康对照者超敏C反应蛋白(hsCRP)、胰岛素抵抗、尿酸、胆固醇、甘油三酯的区别.痛风组服用中药四妙丸加味14 d后复查hsCRP、胰岛素抵抗和尿酸.结果 痛风组hsCRP显著高于高尿酸血症组及健康对照组(P<0.01),服用中药治疗后痛风组hsCRP显著下降(P<0.01),尿酸变化无统计学意义.结论 中药四妙丸加味可能是通过减轻炎症反应达到治疗目的 .%Objective To investigate difference between gout and hyperuricemia patients and mechanism of treatment of Chinese herbal medicine Jiaweisimiaowan on gout.Methods Gout group(n=30),simple hyperuricemia group(n=32)and control group(n=31)were observed.Patients of gout group took Jiaweisimiaowan for 14 days.Levels of blood high sensitive C reactive protein(hsCRP),resistance of insulin,uric acid,cholesterol and triglycerides were measured.Results hsCRP in gout group was obviously higher than that in hyperuricemia group and control group(P<0.01).There were no difference in resistance of insulin,cholesterol and triglycerides between gout and hyperuricemia group.hsCRP in gout group was obviously lower after taking Jiaweisimiaowan while uric acid did not change.Conclusions Jiaweisimiaowan has effect of anti-inflammation on gout patients.

  10. [Cloud Point extraction for determination of mercury in Chinese herbal medicine by hydride generation atomic fluorescence spectrometry with optimization using Box-Behnken design].

    Science.gov (United States)

    Wang, Mei; Li, Shan; Zhou, Jian-dong; Xu, Ying; Long, Jun-biao; Yang, Bing-yi

    2014-08-01

    Cloud point extraction (CPE) is proposed as a pre-concentration procedure for the determination of Hg in Chinese herbal medicine samples by hydride generation-atomic fluorescence spectrometry (HG-AFS). Hg2+ was reacted with dithizone to form hydrophobic chelate under the condition of pH. Using Triton X-114, as surfactant, chelate was quantitatively extracted into small volume of the surfactant-rich phase by heating the solution in a water bath for 15 min and centrifuging. Four variables including pH, dithizone concentration, Triton X-114 concentration and equilibrium temperature (T) showed the significant effect on extraction efficiency of total Hg evaluated by single-factor experiment, and Box-Behnken design and response surface method- ology were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum extraction efficiency. The results showed that the binomial was used to fit the response to experimental levels of each variable. ALL linear, quadratic terms of four variables, and interactions between pH and Trion X-114, pH and di- thizone affected the response value(extraction efficiency) significantly at 5% level. The optimum extraction conditions were as follows: pH 5.1, Triton X-114 concentration of 1.16 g x L(-1), dithizone concentration of 4.87 mol x L(-1), and T 58.2 degrees C, the predicted value of fluorescence was 4528.74 under the optimum conditions, and the experimental value had only 2.1% difference with it. Under the conditions, fluorescence was linear to mercury concentration in the range of 1-5 microg x L(-1). The limit of detection obtained was 0.01247 microg x L(-1) with the relative standard deviations (R.S.D.) for six replicate determinations of 1.30%. The proposed method was successfully applied to determination of Hg in morindae Radix, Andrographitis and dried tangerine samples with the recoveries of 95.0%-100.0%. Apparently Box-Behnken design combined with

  11. 三种中草药抗氧化性研究%Study on Antioxidant Activities of Three Types of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    韩明; 蔺志铎; 薛福玲; 吴冬青

    2009-01-01

    The microware assisted extraction technique was used to extract flavonids from Geranium wilfordii Maxim, Siegesbeckia orientalis L.,Oldenlandia diffusa (Willd.) Roxb. Meanwhile, the antioxidative activities of three types of Chinese herbal medicines were studied by determining the reducing capacity, antioxidative activity in lipid and scavenging effects on hydroxyl radical. The flavonoid content from theirs were Geranium wilfordii Maxim (132. 516 mg/g), Siegesbeckia orientalis L. (78.4749mg/g),Oldenlandia diffusa(Willd.) Roxb(35. 6519rag/g). The extract had strong reducing capacity and scavenging effects on hydroxyl radical,scavenging effects on hydroxyl radical were positive correlation to extract concentration, and also the extraction possessed antioxidant activities in lipid. Their antioxidant activities had difference. This work offers the new scientific data for the further studies of comprehensive utilization of the Herb resource.%微波辅助法提取3种中草药中黄酮类化合物,从还原能力、清除羟基自由基和抗油脂氧化方面,研究其抗氧化活性.结果表明:3种中草药中,总黄酮含量从高到低依次为:老鹤草(132.516mg/g)、稀莶草(78.4749mg/g)、白花蛇舌草(35.6519mg/g).其提取物具有较好的还原能力,且对羟基自由基均有明显的清除作用,其清除效果随提取物浓度的增加而增强.三种中草药提取物也具有一定的抗油脂氧化能力,它们的抗氧化能力存在差异.实验结果为我们更加合理开发利用这些药用植物提供了很好的科学依据.

  12. The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Shi Guang Li

    Full Text Available Many published studies reflect the growing application of complementary and alternative medicine, particularly Chinese herbal medicine (CHM use in combination with conventional cancer therapy for advanced non-small cell lung cancer (NSCLC, but its efficacy remains largely unexplored. The purpose of this study is to evaluate the efficacy of CHM combined with conventional chemotherapy (CT in the treatment of advanced NSCLC. Publications in 11 electronic databases were extensively searched, and 24 trials were included for analysis. A sum of 2,109 patients was enrolled in these studies, at which 1,064 patients participated in CT combined CHM and 1,039 in CT (six patients dropped out and were not reported the group enrolled. Compared to using CT alone, CHM combined with CT significantly increase one-year survival rate (RR = 1.36, 95% CI = 1.15-1.60, p = 0.0003. Besides, the combined therapy significantly increased immediate tumor response (RR = 1.36, 95% CI = 1.19-1.56, p<1.0E-5 and improved Karnofsky performance score (KPS (RR = 2.90, 95% CI = 1.62-5.18, p = 0.0003. Combined therapy remarkably reduced the nausea and vomiting at toxicity grade of III-IV (RR = 0.24, 95% CI = 0.12-0.50, p = 0.0001 and prevented the decline of hemoglobin and platelet in patients under CT at toxicity grade of I-IV (RR = 0.64, 95% CI = 0.51-0.80, p<0.0001. Moreover, the herbs that are frequently used in NSCLC patients were identified. This systematic review suggests that CHM as an adjuvant therapy can reduce CT toxicity, prolong survival rate, enhance immediate tumor response, and improve KPS in advanced NSCLC patients. However, due to the lack of large-scale randomized clinical trials in the included studies, further larger scale trials are needed.

  13. Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression

    Institute of Scientific and Technical Information of China (English)

    ZHANG You-zhi; LI Yun-feng; YU Neng-jiang; YUAN Li; ZHAO Yi-min; XIAO Wen-bin; LUO Zhi-pu

    2007-01-01

    Background Xiaobuxin-Tang, a traditional Chinese herbal prescription recorded in a silk scroll unearthed from Mogao Caves of Dunhuang has been indicated that it can remit depressive disorder. The present study was designed to investigate its antidepressant effects in various animal depression models.Methods Xiaobuxin-Tang was extracted by 70% alcohol, and then three behavioral despair models and 5-Hydroxytryptophan (HTP)-induced head twitch response model were adopted to assess the antidepressant effects of the ethanolic extract of Xiaobuxin-Tang with the study on spontaneous motor activity. Groups of mice and rats received oral treatment with Xiaobuxin-Tang (150-1200 mg/kg) only once acutely in all tests. The duration of immobility was measured during the last 4 minutes of the 6-minutes test period in mice forced swimming test, rats forced swimming test and mice tail suspension test. In 5-HTP-induced head twitch response, the mice were intraperitoneally administered with 120 mg/kg of L-5-HTP, and then the cumulative number of head twitches was counted in 20 minutes. Spontaneous motor activities of mice were recorded automatically in 10 minutes by VIDEOMEX-V image analyticsystem.Results The extract at doses of 300 mg/kg (p.o.) and 600 mg/kg (p.o.) significantly decreased the duration of immobility time in a dose dependent manner in mice forced swimming test; also, the extract at dose of 1200 mg/kg (p.o.)significantly decreased the duration of immobility time in rat forced swimming test. Furthermore, the extract at a dose of 600 mg/kg had the same effect in mice tail suspension test. Meanwhile, the extract at the effective doses for behavioral despair models, had no effect on spontaneous motor activity in mice. The extract (300-1200 mg/kg, p.o.) also increased the accumulative number of the 5-HTP-induced head twitch response in mice in 20 minutes.Conclusion Our results suggested that the ethanolic extract of Xiaobuxin-Tang exerts antidepressant-like effect.

  14. Illustration of compositional variations over time of Chinese porcelain glazes combining micro-X-ray Fluorescence spectrometry, multivariate data analysis and Seger formulas

    Science.gov (United States)

    Van Pevenage, J.; Verhaeven, E.; Vekemans, B.; Lauwers, D.; Herremans, D.; De Clercq, W.; Vincze, L.; Moens, L.; Vandenabeele, P.

    2015-01-01

    In this research, the transparent glaze layers of Chinese porcelain samples were investigated. Depending on the production period, these samples can be divided into two groups: the samples of group A dating from the Kangxi period (1661-1722), and the samples of group B produced under emperor Qianlong (1735-1795). Due to the specific sample preparation method and the small spot size of the X-ray beam, investigation of the transparent glaze layers is enabled. Despite the many existing research papers about glaze investigations of ceramics and/or porcelain ware, this research reveals new insights into the glaze composition and structure of Chinese porcelain samples. In this paper it is demonstrated, using micro-X-ray Fluorescence (μ-XRF) spectrometry, multivariate data analysis and statistical analysis (Hotelling's T-Square test) that the transparent glaze layers of the samples of groups A and B are significantly different (95% confidence level). Calculation of the Seger formulas, enabled classification of the glazes. Combining all the information, the difference in composition of the Chinese porcelain glazes of the Kangxi period and the Qianlong period can be demonstrated.

  15. Guizhi Fuling Wan, a Traditional Chinese Herbal Formula, Sensitizes Cisplatin-Resistant Human Ovarian Cancer Cells through Inactivation of the PI3K/AKT/mTOR Pathway

    Directory of Open Access Journals (Sweden)

    Li Han

    2016-01-01

    Full Text Available The aim of the study was to explore the possible mechanisms that Guizhi Fuling Wan (GFW enhances the sensitivity of the SKOV3/DDP ovarian cancer cells and the resistant xenograft tumours to cisplatin. Rat medicated sera containing GFW were prepared by administering GFW to rats, and the primary bioactive constituents of the sera were gallic acid, paeonol, and paeoniflorin analysed by HPLC/QqQ MS. Cell counting kit-8 analysis was shown that coincubation of the sera with cisplatin/paclitaxel enhanced significantly the cytotoxic effect of cisplatin or paclitaxel in SKOV3/DDP cells. The presence of the rat medicated sera containing GFW resulted in an increase in rhodamine 123 accumulation by flow cytometric assays and a decrease in the protein levels of P-gp, phosphorylation of AKT at Ser473, and mTOR in a dose-dependent manner in SKOV3/DDP cells by western blot analysis, but the sera had no effect on the protein levels of PI3K p110α and total AKT. The low dose of GFW enhanced the anticancer efficacy of cisplatin and paclitaxel treatment in resistant SKOV3/DDP xenograft tumours. GFW could sensitize cisplatin-resistant SKOV3/DDP cells by inhibiting the protein level and function of P-gp, which may be medicated through inactivation of the PI3K/AKT/mTOR pathway.

  16. The Chinese herbal formula Tongluo Jiunao promotes expression of brain-derived neurotrophic factor/tropomyosin-related kinase B pathways in a rat model of ischemic brain injury

    Institute of Scientific and Technical Information of China (English)

    Peiman Alesheikh; Yangyang Yan; Huiling Tang; Pengtao Li; Wei Zhang; Yanshu Pan; Arezou Mashoufi; Liyun Zhao; Runjun Wang; Bo Di

    2011-01-01

    The neurotrophin-Trk receptor pathway is an intrinsic pathway to relieve damage to the central nervous system. The present study observed the effects of Tongluo Jiunao (TLJN), which comprises Panax Notoginseng and Gardenia Jasminoides, on expression of brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) in a rat model of focal cerebral ischemic injury. Xue Sai Tong (XST), comprising Panax Notoginseng, served as the positive control. Mechanisms of neuroprotection were analyzed following TLJN injection. Following establishment of the middle cerebral artery occlusion models, TLJN and XST were intraperitoneally injected, and 2, 3, 5-triphenyltetrazolium chloride staining results revealed that TLJN injection reduced infarct volume, suggesting that TLJN exerted a neuroprotective effect. Enzyme-linked immunosorbent assay results showed that TLJN elevated BDNF and growth associated protein-43 expression in ischemic brain tissues, as well as serum BDNF levels. Reverse-transcription polymerase chain reaction and western blot results showed that TLJN injection did not affect TrkB expression in the ischemic brain tissues of rats. These results suggested that TLJN injection reduced damage to ischemic brain tissues and increased BDNF expression. In addition, TLJN injection resulted in better promoting effects on neurotrophic factor expression compared with XST.

  17. Jiang Tang Xiao Ke Granule, a Classic Chinese Herbal Formula, Improves the Effect of Metformin on Lipid and Glucose Metabolism in Diabetic Mice

    Science.gov (United States)

    Zhang, Yi; An, Hong; Pan, Si-Yuan; Zhao, Dan-Dan; Zuo, Jia-Cheng; Li, Xiao-Ke; Gao, Ya; Mu, Qian-Qian; Yu, Na; Ma, Yue; Mo, Fang-Fang; Gao, Si-Hua

    2016-01-01

    In the present study, the hypoglycemic, hypolipidemic, and antioxidative effects of metformin (MET) combined with Jiang Tang Xiao Ke (JTXK) granule derived from the “Di Huang Tang” were evaluated in mice with type 2 diabetes mellitus (DM) induced by high-fat diet/streptozotocin. DM mice were orally treated with MET (0.19 g/kg) either alone or combined with different doses (1.75, 3.5, or 7 g/kg) of JTXK for 4 weeks. Results showed that the serum and hepatic glucose, lipids, and oxidative stress levels were elevated in DM mice, when compared with the normal mice. MET treatment decreased FBG and serum glucagon levels of DM mice. Combination treatment with MET and JTXK 3.5 g/kg increased the hypoglycemia and insulin sensitivity at 4 weeks when compared with the DM mice treated with MET alone. However, neither MET nor MET/JTXK treatment could completely reverse the hyperglycemia in DM mice. JTXK enhanced the serum triglyceride (TG) and hepatic lipid-lowering effect of MET in a dose-dependent manner in DM mice. JTXK 1.75 and 3.5 g/kg improved the hepatoprotective effect of MET in DM mice. Synergistic effect of combination treatment with MET and JTXK on antioxidant stress was also found in DM mice compared with MET alone. PMID:27418937

  18. Therapeutic Actions of the Chinese Herbal Formulae with Cold and Heat Properties and Their Effects on Ultrastructures of Synoviocytes in Rats of the Collagen-Induced Arthritis

    Institute of Scientific and Technical Information of China (English)

    李梢; 吕爱平; 贾宏伟

    2002-01-01

    The therapeutic actions of Qing Luo Yin (QLY清络饮) with heat property and Wen Luo Yin (WLY温络饮) with cold property on pain, swelling of the ankle, arthritis index and ultrastructures of synoviocytes were compared in rats of type II collagen-induced arthritis (CIA), with tripterygium glycosidorum (TG) used as control. The results indicated that both QLY and WLY could reduce pain, swelling of the ankle and the arthritis index of CIA, and QLY had better effects in reducing the swelling of the ankle and controlling the secondary pathological lesions as compared with WLY. Investigation on the ultrastructures of synoviocytes indicated that both QLY and WLY could reduce the number of Golgi apparatus, rough surface endoplasmic reticulum, dense bodies, matrix filaments and vacuoles so as to suppress the excessive secretion of synoviocytes in rats of CIA.

  19. Comparative in vitro dissolution of two commercially available Er-Zhi-Wan herbal medicinal products

    Directory of Open Access Journals (Sweden)

    M Wang

    2015-01-01

    Full Text Available In vitro dissolution test is an essential tool to assess the quality of herbal medicinal products in the solid dosage forms for oral use. Our work aimed to evaluate the dissolution behavior of Er-Zhi-Wan, in the formulations of water-honeyed pill and formula granule. Different media (water, 30% EtOH, 0.1 M HCl, acetate buffer, pH 4.5 and phosphate buffer, pH 6.8 were used following United States Pharmacopoeia and Chinese Pharmacopeia. An ultra-high performance liquid chromatography method was developed and validated to detect simultaneously six active ingredients for quantification and dissolution study (salidroside, specnuezhenide, nuezhenoside, luteolin, apigenin, oleanolic acid. As we observed, contents of main active ingredients were close in the two formulations for daily dose. In each medium, more ingredients dissolved from formula granule with higher Ymax and Ka. The mean dissolution time of the most ingredients in granule was significantly shorter than that in pill in acetate buffer, pH 4.5 and phosphate buffer, pH 6.8. Furthermore, salidroside, specnuezhenide and luteolin dissolved more than 80% in 30 min from formula granule, which indicated higher solubility along the intestinal tract according to biopharmaceutics classification system. The dissolution test developed and validated was adequate for its purposes and could be applied for quality control of herbal medicine. This work also can be used to provide necessary information on absorption for its biopharmaceutical properties.

  20. Context Effects in Western Herbal Medicine: Fundamental to Effectiveness?

    Science.gov (United States)

    Snow, James

    2016-01-01

    Western herbal medicine (WHM) is a complex healthcare system that uses traditional plant-based medicines in patient care. Typical preparations are individualized polyherbal formulae that, unlike herbal pills, retain the odor and taste of whole herbs. Qualitative studies in WHM show patient-practitioner relationships to be collaborative. Health narratives are co-constructed, leading to assessments, and treatments with personal significance for participants. It is hypothesized that the distinct characteristics of traditional herbal preparations and patient-herbalist interactions, in conjunction with the WHM physical healthcare environment, evoke context (placebo) effects that are fundamental to the overall effectiveness of herbal treatment. These context effects may need to be minimized to demonstrate pharmacological efficacy of herbal formulae in randomized, placebo-controlled trials, optimized to demonstrate effectiveness of WHM in pragmatic trials, and consciously harnessed to enhance outcomes in clinical practice. PMID:26613625

  1. Analysis on the dosage of Chinese herbal medicine prescription survey results%对中药饮片处方中用药剂量调查结果的分析

    Institute of Scientific and Technical Information of China (English)

    邱爱功

    2015-01-01

    ObjectiveStatistics of Chinese Herbal Medicine prescription medication doses,analyzed and discussed their medication reasonable.MethodsIn our hospital from January 2013 to December 2013 out of Chinese Herbal Medicine prescription randomly selected 880, These prescription medication dosage and medication standard Chinese Pharmacopoeia in the relevant comparison.Results880 prescriptions, the most frequently used drugs are: Licorice 846, Poria 832, Atractylodes 829, Yiyiren 825, Banxia 818, the heaviest overdose is Banxia (96.1%), Citrus (73.3%), Guizhi (86.6%),Ligusticum wallichii (84.5%), Radix (85.3%).ConclusionThe Court dosage Chinese Herbal Medicine in the presence of prescription drug overdose, not only a waste of drugs may also cause adverse reactions in patients, we should be rational drug use.%目的:统计中药饮片处方中用药剂量的情况,分析探讨其用药合理性。方法在我院2013年1月~2013年12月开出的中药饮片处方中随机抽取880张,将这些处方中的用药剂量与《中国药典》中相关的用药标准进行对比。结果本组880张处方中,使用频率最高的药物是:甘草846张、茯苓832张、白术829张、薏苡仁825张、半夏818张,剂量最重的是半夏(96.1%),陈皮(73.3%),桂枝(86.6%),川芎(84.5%),柴胡(85.3%)。结论本院中药饮片处方中的用药剂量存在超剂量使用药物的情况,不仅浪费药物,还可能造成患者不良反应,我们应该合理用药。

  2. Monitoring of mercury, arsenic, and lead in traditional Asian herbal preparations on the Dutch market and estimation of associated risks

    NARCIS (Netherlands)

    Martena, M.J.; Wielen, van der J.C.A.; Rietjens, I.; Klerx, W.N.M.; Groot, de H.N.; Konings, E.J.M.

    2010-01-01

    Traditional herbal preparations used in Ayurveda, traditional Chinese medicine, traditional Tibetan medicine, and other Asian traditional medicine systems may contain significant amounts of mercury, arsenic or lead. Though deliberately incorporated in Asian traditional herbal preparations for therap

  3. 中草药制剂对哺乳母猪繁殖性能的影响%Effects of Chinese Herbal Feed Additive on the Reproductive Performance of Lactating Sows

    Institute of Scientific and Technical Information of China (English)

    杜少甫; 谢红兵; 王泽政; 韦光辉; 苗志国; 魏刚才

    2016-01-01

    [目的]研究中草药饲料制剂对哺乳母猪繁殖性能的影响,为其在哺乳母猪生产中的应用提供理论依据。[方法]选择60头经产母猪,随机分为5组,每组12头母猪,对照组饲喂玉米-豆粕型基础饲料,试验Ⅰ组基础日粮+0.5%中草药添加剂,试验Ⅱ组基础日粮+1.0%中草药添加剂,试验Ⅲ组基础日粮+1.5%中草药添加剂,试验Ⅳ组为基础日粮+0.04%强力霉素,研究中草药饲料制剂对哺乳母猪繁殖性能的影响。[结果]试验Ⅰ组、Ⅱ组、Ⅲ组、Ⅳ组母猪的窝产仔数、健仔率和10日龄仔猪日增重显著提高,母猪恶露的排出率显著提高。在基础日粮中添加中草药制剂能促进母猪的子宫恢复。试验Ⅰ组、Ⅱ组、Ⅲ组、Ⅳ组初生猪黄白痢的发生率显著降低,各试验组间差异不显著。[结论]中药制剂能增强新生仔猪及母猪的抗病力,提高母猪的繁殖力,以添加1%中草药制剂的效果最佳。%Objective] To research the effects of Chinese herbal feed additive on the reproductive performance of lactating sows, and to pro-vide theoretical foundation for the application in lactating sows production.[Method] A total of 60 multiparous sows were randomly allocated to five treatments with twelve replicates per treatment.Sows in the control group were fed with a corn soybean meal basal feed; test group 1 was fed with basal diet and 0.5% Chinese herbal medicine additive; experiment group II were fed basal diet and 1.0% Chinese herbal medi-cine additive, the test group III was fed with based diet and 1.5% Chinese herbal medicine additive, test group IV were fed the basal diet and 0.04% doxycycline.[Result] The test group I, group II, group III and group IV significantly improved the litter size, healthy piglet rate, and weight gain in piglets of 10-day-old piglets, significantly improved the discharge of lochia sows, and promoted the recovery of the

  4. NursingInterventionwithChineseHerbalMedicineontheImpactofOralLichenPlanus%护理干预配合中草药对口腔扁平苔藓的影响

    Institute of Scientific and Technical Information of China (English)

    王丽娟

    2013-01-01

    Objective Explore the nursing intervention with herbal efficacy of oral lichen planus, and the degree of oral mucositis associated with clinical efficacy. Methods In our hospital dental clinic clinical diagnosis and oral pathology diagnosis of Erosive Oral Lichen Planus 40 patients. Chinese herbal medicine given treatment group and control group was given the order Pixin sprays. Results Two months after the referral, come nursing intervention with herbal oral lichen planus is the most effective and safe ways to improve the image of T lymphocytes in peripheral blood of patients with a clear two-way adjustment, while improving the body's immune force. Conclusion After long-term clinical exploration and research, Chinese herbal medicine in the treatment of oral lichen planus, not only can markedly improve the patient's local symptoms, but also to regulate their body immune function, healing rarely relapse, so as to achieve the role of tackling the problem.%  目的探讨护理干预配合中草药对口腔扁平苔藓的疗效,以及口腔黏膜炎程度与临床疗效的相关性。方法通过对我院口腔科门诊中临床诊断及口腔病理学确诊为糜烂型口腔扁平苔藓40例患者。给予治疗组中草药制剂,对照组给予的令皮欣喷雾剂。结果2个月后复诊,得出护理干预配合中草药是对口腔扁平苔藓最有效的、安全的方法之一,提高了患者外周血像中T淋巴细胞有明显的双向调节作用,同时提高了机体的免疫力。结论经过长期的临床探索和研究,中草药在治疗口腔扁平苔藓方面,不仅能显效的改善患者的局部症状,还能调节其全身免疫功能,愈合很少复发,从而达到标本兼治的作用。

  5. Use of primate models in developing Chinese herbal drugs for the treatment of AIDS%灵长类动物模型在中医药防治艾滋病研究中的应用

    Institute of Scientific and Technical Information of China (English)

    陈剑涛; 李茂清; 符林春

    2012-01-01

    As AIDS is among the most devastating disease of our time and incurable,animal models are urgently needed to test new antiretroviral drugs and vaccines. Primate models, which are regarded as the most practical animal models developed to date, also provide a good platform for study of Chinese herbal therapy for HIV/AIDS. Although these models are useful, they have drawbacks in evaluating efficacy of traditional drugs due to the lack of features of traditional Chinese medicine. Here, we discuss the uses and limitations of existing models and strategies that might lead to better animal models for improvement of Chinese herbal therapy for HIV/AIDS.%动物模型是药物研发和疫苗评价的重要平台,对于抗艾滋病药物和疫苗研究也是不可或缺的.在中医药抗艾滋病研究中,动物模型发挥着重要的作用.但是目前所用动物模型主要为常用的猴免疫缺陷病毒(SIV)感染的猴模型,由于缺少中医特色,对于评价中医药的疗效尚有不足之处.文章简要介绍了灵长类动物艾滋病(AIDS)模型在中医药防治艾滋病研究领域的应用情况,并对目前存在的问题和未来努力的方向进行了探讨.

  6. Determination of ingredients in Chinese herbal medicine and its preparation%中药当归及其制剂中成分预处理和含量测定

    Institute of Scientific and Technical Information of China (English)

    吴冰

    2015-01-01

    目的:探讨中药当归及其制剂中成分预处理和含量测定。方法选取我院2013年8月至2015年8月实施中药当归及其制剂的100例患者作为研究对象,对其基本资料予以回顾性分析,予以观察其成分预处理情况以及含量测定情况。结果中药当归中,阿魏酸、多糖、挥发油以及微量元素含量各不相同。结论当归的产地不同、预处理方法不同,其含量测定结果不同,其中,利用毛细管电泳法对当归中的阿魏酸含量予以测定效果显著,具有一定的应用价值以及良好的发展空间。%Objective:To investigate the contents of the ingredients in the Chinese herbal medicine and its preparation. Method 100 cases of Chinese angelica and its preparation from August 2015 to August 2013 were selected as the research object, and the basic data were retrospectively analyzed.Result Chinese herbal medicine, ferulic acid, polysaccharide, essential oil and trace element content of different.Conclusion:The contents of ferulic acid in Angelica sinensis were determined by capillary electrophoresis, and the results were significant, and it has some application value and good development space.

  7. Effects of dietary Chinese herbal medicine compounds on antioxidant capacity in rainbow trout%复方中草药对虹鳟抗氧化能力的影响

    Institute of Scientific and Technical Information of China (English)

    孙裔雷; 王荻; 刘红柏

    2015-01-01

    A feeding trial was conducted to evaluate the effects of two kinds of Chinese herbal compound on antioxidant defenses of rainbow trout Oncorhynchus mykiss for application of Chinese herbal compound in rainbow trout culture.Juvenile rainbow trout of 1+old with body weight of(200.0±1.5)g were randomly divided into outdoor circulating circular tanks at a rate of 120 fish per tank and fed basal diet and the diets containing two kinds of Chinese herbal medicine compounds(No.1 Artemmisia capillaries and Isatis indigotica;No.2 Arnebia guttata and Lonicera japonic)at feeding rate of 2.5% with duplication at water temperature of(17±1)℃ for 30 days.The NO and malonaldehyde(MDA)contents, activities of total nitric oxide synthase(TNOS), inducible nitric oxide synthase(iNOS), superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)and total antioxidant capacity(T-AOC)were determined in serum, liver, spleen and kidney of the rainbow trout fasted for 24 hours at the end of the experiment.The results showed that there were significantly higher activity of SOD and significantly lower content of MDA in liver in the rainbow trout fed the diets containing Chinese herbal medicines than those in the juveniles fed the basal diet(P<0.05).The contents of NO in liver, spleen and kidney, the activity of iNOS in spleen, and the serum T-AOC were found to be increased significantly in the rainbow trout fed the diets containing Chinese herbal compound 1(P<0.05), with higher activity of GSH-PX in serum.The rainbow trout fed the diets containing Chinese herbal compound 2 had significantly higher content of NO in the kidney.The findings indicate that compound 1 improves the antioxidant capacity effectively, and can be used as an excellent antioxidant of Chinese herbal medicine for rainbow trout.%为了将中草药作为饲料添加剂长期应用于虹鳟养殖生产, 探讨了复方中草药对虹鳟Oncorhynchus mykiss抗氧化能力的影响.在水温为(17±1)℃条件下,

  8. 中药局部熏蒸治疗偏瘫肩痛的临床疗效观察%Clinical Observation of Chinese Herbal Fumigation and Steaming Therapy for Shoulder Pain After Hemiplegia

    Institute of Scientific and Technical Information of China (English)

    彭银英; 朱乐英

    2013-01-01

    Objective To observe the therapeutic effect of Chinese herbal fumigation and steaming therapy for shoulder pain after hemiplegia. Methods Forty-eight hemiplegia complicated with shoulder pain were equally randomized into two groups. The treatment group was given Chinese herbal fumigation and steaming therapy combined with rehabilitation therapy, and the control group was given rehabilitation therapy alone. The range of movement (ROM) of shoulder and visual analog scale (VAS) for pain were scored for the evaluation of therapeutic effect. Results The scores of ROM and VAS were improved in both groups (P <0. 05 compared with those before treatment ) , and the improvement in the treatment group was superior to that in the control group (P < 0. 05). Conclusion Chinese herbal fumigation and steaming therapy combined with rehabilitation therapy is effective on relieving shoulder pain, improving shoulder function and reducing disability for the treatment of shoulder pain after hemiplegia.%[目的]观察中药局部熏蒸治疗及现代康复治疗对偏瘫并发肩痛的临床疗效.[方法]设现代康复训练治疗偏瘫肩痛为对照组(24例),中药局部熏蒸结合康复训练治疗偏瘫肩痛为治疗组(24例),观察2组治疗前后肩关节活动度(ROM)以评价肩关节活动范围的变化,并观察视觉模拟类比评分(VAS)以评定患侧肩关节疼痛状况.[结果]治疗后2组患者ROM积分和VAS评分均有显著改善,与治疗前比较差异均有统计学意义(P<0.05);且治疗组的改善作用更为显著,与对照组比较差异均有统计学意义(P<0.05).[结论]中药局部熏蒸治疗结合现代康复手段在偏瘫并发肩痛治疗中可有效缓解患者偏瘫肩痛情况,促进患肩关节功能的恢复,减少偏瘫患者的致残程度,提高中风后偏瘫患者的临床疗效.

  9. 中草药添加剂对豪猪防病和促生长效果的研究%Study on the Disease Prevention and Growth-promoting Effects of Chinese Herbal Additives on Porcupine

    Institute of Scientific and Technical Information of China (English)

    王玉霞; 高慧林; 唐瑞华; 任国冀; 王前光; 张保平

    2013-01-01

    [Objective] The research aimed to screen out some Chinese herbal additives that could promote the growth of porcupine and prevent the diseases.[Method] According to the physiological characteristics and incidence characteristics of porcupine,based on the feeding standards of similar animals and local resources,feeding experiment with different Chinese herbal additives was conducted to study the disease prevention and growth-promoting effects of porcupine.[Result] In experiment group Ⅰ,the average daily gain increased by 49.2%,feed-gain ratio decreased by 19.31%,economic benefits improved by 71.8% and disease prevention rate was 100%.In experiment group Ⅱ,the average daily gain increased by 30.26%,feed-gain ratio decreased by 11.11%,the economic effects increased by 70.3% and disease prevention rate was 89.9%.[Conclusion] The effect of Chinese herbal additive in experiment group Ⅰ was the best.%[目的]筛选可促进仔豪猪生长和抗病作用的中草药添加剂.[方法]根据豪猪的生理特性和发病特点,结合同类动物的饲养标准及本地资源,通过中草药组方进行饲养试验,对豪猪的防病及促生长效果进行研究.[结果]试验Ⅰ组豪猪平均日增重提高49.2%,料重比降低19.31%,经济效益提高了71.8%,防病率为100%;试验Ⅱ组豪猪平均日增重提高30.26%,料重比降低11.11%,经济效益提高了70.3%,防病率为89.9%.[结论]试验Ⅰ组中草药添加剂的效果最佳.

  10. 中药联用厄贝沙坦治疗糖尿病肾病微量白蛋白尿期的疗效观察%Observation of Combining Chinese Herbal Medicine with Irbesartan Early Stage Diabetic Nephrosis

    Institute of Scientific and Technical Information of China (English)

    鲍红娟

    2011-01-01

    Objective :To inquire into the therapeutic effect and mechanisms of chinese herbal medicine combined with irbesartan for treatment of early stage diabetic nephropathy.Methods:88 patients with early stage diabetic nephrosis were randomly divided into 2 groups.The control group( n =44) was treated with irbesartan, diabetic diet, controlling glucose etc.The treatment group( n =44) treated with chinese herbal medicine.Six weeks constituted one course.Changes of urea nitrogen, serum creatinie, blood lipid, glycosylated hemoglobin,MDA,SOD, CRP and ACR before and after treatment were investigated.Results:After treatment, investigated indexes except urea nitrogren ,serum creatinine and glycosylated hemoglobin, improved significantly in the treatment group( P < 0.01 ).Conclusion :chinese herbal medicine and irbesartan can markedly decrease ACR.%目的:探讨中药联用厄贝沙坦治疗糖尿病肾病(DN)微量白蛋白尿期的疗效和作用机制.方法:将糖尿病微量白蛋白尿期患者88例随机分成治疗组与对照组,每组44例,对照组给予糖尿病饮食、控制血糖及口服厄贝沙坦片等常规治疗,治疗组在常规治疗的基础上加用中药口服.两组均以6周为1个疗程.观察两组治疗前后ACR(尿白蛋白与肌酐的比值)、尿素氮、血肌酐、血脂、血糖、糖化血红蛋白、丙二醛、超氧化物歧化酶、CRP等指标变化.结果:治疗组治疗后除尿素氮、血肌酐、糖化血红蛋白等外其他各项指标与对照组比较均有明显改善(P<0.01).结论:中药联用厄贝沙坦有较好的降低尿微量白蛋白及改善血糖血脂的作用.

  11. 具有抑菌和杀虫活性的中草药资源及在农药上的应用%Chinese Herbal Medicine Resources with Bacteriostatic and Insecticidal Activities and Their Application as Pesticides

    Institute of Scientific and Technical Information of China (English)

    陈阳峰; 钟晓红; 陈烈臣

    2013-01-01

    中草药源农药是指从中草药中提取的用于防治农作物病虫害的有效成分或从中分离纯化的单体物质,它在无公害农产品生产和开发利用我国丰富的植物资源用于有害生物的防治方面具有深远意义。概述了中草药源农药对环境友好、作用方式多样、对高等动物及害虫天敌安全,且有害生物较难产生抗药性等特点;综述了49科具有抑菌和杀虫活性的中草药资源及其作用,评述了我国已开发应用的19种中草药源农药和7种规模化生产的中草药源农药产品。最后,提出了中草药农药开发应用中值得进一步研究的问题:中草药的品种选育、栽培技术和活性成分提取方法研究;中草药源有效成分的结构鉴定,植物品种与活性成分关系的基础研究;以中草药源活性成分为基础的先导化合物的研发。%Herbal pesticides refer to the active ingredients extracted from herbs which are used for pest and disease control in crops or pure substances isolated from them. They are of great significance for the production of pol ution-free agricultural products, as wel as for exploiting the abundant plant resources in China for the prevention and control of pests. In this paper, the advantages of herbal pesticides, such as being environment-friendly, diverse patterns of action, safety for higher ani-mals and the natural enemies of pests and making it hard for pests to produce re-sistance were first stated; then, Chinese herbal medicine resources with antibacterial and insecticidal activities from 49 families and their functions were reviewed, and 19 kinds of herbal pesticides that have been developed and applied in China and sev-en kinds that have been produced on a large scale were also introduced; final y, three issues deserving further exploration during the development and application of herbal pesticides were presented, that is, research in variety selection and cultivation of

  12. Coprescription of Chinese herbal medicine and Western medication among female patients with breast cancer in Taiwan: analysis of national insurance claims

    Directory of Open Access Journals (Sweden)

    Wang BR

    2014-05-01

    Full Text Available Bih-Ru Wang,1,2,* Yuh-Lih Chang,1,2,* Tzeng-Ji Chen,3,4 Jen-Hwey Chiu,5,6 Jing Chong Wu,7 Min-Shan Wu,1 Chia-Lin Chou,1 Yueh-Ching Chou1,2,81Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan; 2Department and Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan; 3Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 4Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan; 5Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; 6Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 7Traditional Medicine Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 8College of Pharmacy, Taipei Medical University, Taipei, Taiwan*These authors contributed equally to this workBackground: Many female breast cancer (FBC patients take Chinese herbal medicine (CHM and Western medication (WM concurrently in Taiwan. Despite the possibility of interactions between the CHM and WM mentioned in previous studies, the pattern of these coprescriptions in FBC patients remains unclear. Hence, the aim of the present study is to investigate the utilization of coprescriptions of CHM and WM among the FBC patients in Taiwan.Methods: The study was a cross-sectional survey using the sampled cohort in 2009 obtained from the National Health Insurance Research Database in Taiwan. There were 3,507 FBC patients identified from the registry for catastrophic illness patients. Ambulatory visit records, corresponding prescriptions, and the data of beneficiaries belonging to the FBC patients were further extracted. A total of 1,086 FBC patients used CHM at least once. CHM and WM prescribed within any overlapping duration were defined as coprescriptions.Results: There were 868 (80.0% patients simultaneously receiving CHM and WM. A total of 4,927 CHM prescriptions and 6,358 WM

  13. Efficacy of Chinese Herbal Medicine against Cow Endometritis%复方中草药防治奶牛子宫内膜炎的效果

    Institute of Scientific and Technical Information of China (English)

    何光中; 刘镜; 杨红文; 何金平

    2011-01-01

    [目的]探讨复方中草药灌注液“宫舒康”治疗奶牛子宫内膜炎的安全性和临床效果.[方法]在贵阳市清镇奶牛小区和乌当奶牛小区开展了临床试验.选取311头患有子宫内膜炎的产后奶牛,随机分为2组,即复方中草药“宫舒康”治疗组和长效盐酸土霉素治疗组,并依据病情轻重分组治疗.[结果]在治疗轻度、中度子宫内膜炎病例时,复方中草药“宫舒康”和长效盐酸土霉素均取得了较高的治愈率和有效率,但中草药“宫舒康”组比对照组缩短了患牛症愈后恢复发情的时间,并显著提高了受胎率(0.01 <P <0.05);在治疗重度子宫内膜炎时,复方中草药“宫舒康”组的治愈率极显著低于长效盐酸土霉素组的治愈率(P<0.01),但有效率却显著高于土霉素组(0.01 <P <0.05).[结论]复方中草药“宫舒康”具有抗菌消炎、诱导发情和提高受胎率的作用,在治疗轻度、中度子宫内膜炎时疗效明显优于对照组;在治疗重度子宫内膜炎时疗效较差,建议采用对照组的治疗方案或2种方案结合治疗.%[Objective] To investigate safety and clinical efficacy of compound Chinese herbal medicine (Gongshukang) against cow endometritis. [ Method ] Clinical trials were constructed in cow community of Qingzhen and Wudang. A total of 311 parental cows suffering from endometri-tis were selected and randomly divided into two groups. The cows in the group Ⅰ were gavaged with Congshukang, and those in the group Ⅱ were administrated with long - acting oxytetracycline hydrochloride. Therapy was based on the severity of illness. [ Result] The cure rate and effective rate were high in mild and moderate cases of the two groups, but the cows in the group Ⅰ needed shorter time to be in heat than those in the group Ⅱ. The pregnancy rate was significantly higher in the group I than in the group Ⅱ (P < 0.05). For severe cases, the cure rate of the group

  14. Probing into the Cognitive Motivation of Formula Metaphor between English and Chinese%英汉套语隐喻的认知理据考略

    Institute of Scientific and Technical Information of China (English)

    王黎

    2015-01-01

    In their book, Metaphor We Live By, Lakoff and Johnson pointed out clearly that metaphor is ubiquitous in our daily life;it is not only a simple rhetorical device, but also a way of thinking expressed by language. It has been postulated, on the basis of theoretical elaboration with adequate instance studies, that the cognitive approach can be introduced to the study of formula be⁃cause this expressive device possesses all the essences of metaphor from the perspective of Cognitive Linguistics. The formula meta⁃phors are gradually cultivated upon human beings’ repetitive and recursive experiences of the real world and cannot be divorced from culture’ s limitation and reformulation. In other words, formula is metaphorical in essence. The common experiences and body struc⁃tures of English speakers and Chinese speakers result in the similarity of formula between these two different languages.%莱考夫和约翰逊在《我们赖以生存的隐喻》中鲜明地指出:隐喻无处不在、无时不有,隐喻不仅是修辞的简单附属品,也是一种由语言承载并凸显的思维方式。以概念隐喻理论为指导,在大量实例的阐释下,试图证明传统意义上的套语是具有隐喻性的。所有的套语概念都是人类在对现实世界反复、多次的体验基础上逐渐形成的,换言之,套语的本质是隐喻性的。英汉语言使用者共同的身体结构及其体验范式决定了两种语言中套语隐喻的趋同性。

  15. The effect of Chinese herbal medicine"heche assisted pregnancy recipe"on endometrial estrogen and progesterone receptor, proliferating cell nuclear antigen and vascular endothelial growth factor in the patients with infertility

    Institute of Scientific and Technical Information of China (English)

    刘效群; 阚国英; 彭玉梅; 樊瑞琴; 齐惠敏; 焦妹芬; 李忠; 石彬; 尹桂然; 董锡月

    2003-01-01

    Objectives:To investigate the effect of Chinese herbal medicine"heche assisted preg-nancy recipe (HCAPR)" on estrogen receptor(ER), progesterone receptor (PR), pro-lifierating cell nuclear antigen(PCNA) and vascular endothelial growth factor (VEGF)in endometrium of infertile women.Methods: The S-P immunohistochemical assay was used to observe expression ofER, PR , PCNA and VEGF in late proliferative phase before and after the HCAPR treat-ment.Results: After the treatment, the expression of ER,PR,PCNA and VEGF in nucleiof glandular epithelium and stromal cells was significantly stronger (all P<0. 001) re-spectively than that before treatment , especially the expression of PCNA and VEGF.Conclusions: These results suggest that traditional Chinese medicine HCAPR oftonifying kidney and regulating menstruation increased the synthesis of ER,PR, PCNAand VEGF, which may promote normal growth and development of the endometrium ,improve the micro-environment of the endometrium, and enhance uterine receptivity.The evidence may provide theoretical basis for therapy infertility with Chinese herbalmedicine.

  16. Influence of Chinese herbal medicine on intraepithelial lymphocyte under heat stress in layers%中草药抗热应激蛋鸡小肠上皮内淋巴细胞的组织学观察

    Institute of Scientific and Technical Information of China (English)

    沈萍; 史秋梅; 高光平; 董淑珍; 尹海力; 杨超

    2012-01-01

    This experiment was designed to study the influence of Chinese herbal medicine on intraepithelial lymphocyte under heat stress in layers. A total of 120 88-day-old layers were randomly assigned to 6 groups, in which 3 groups were treated as experimental groups and the others were treated as the control. The experimen- tal birds were fed basal diet added with high, medium and low levels of Chinese herbal medicine under heat stress, respectively. The control birds were fed basal diet under room or high temperature, or basal diet added with vitamin C under heat stress,respectively. Then five layers of each group were randomly selected and killed on the first, fourth, eighth and tenth day. The small intestine was taken and made sections, and then observed the changes of intraepithelial lymphocyte under the microscope after H. E staining. The results showed that lay- ers fed diet added with Chinese herbal medicine had more intraepithelial lymphocytes than the control birds,and the intraepithelial lymphocytes increased as the added level increased. All of these showed that Chinese herbal medicine can be effective against heat stress and improve the physiological function of layers.%本试验旨在研究蛋鸡热应激情况下中草药对其小肠上皮内淋巴细胞的影响。选取120只88日龄蛋鸡,随机平均分为6个组。任取其中3个组为中草药试验组,分别加入高、中、低浓度的中草药;另3个组为对照组,一组加入维生素C,一组置于高温环境中,一组于室温条件下饲养。分别在试验的第1天、第4天、第8天和第10天随机选取5只鸡致死,取小肠部分做石蜡切片,H.E染色后在显微镜下观察小肠上皮内淋巴细胞的变化。试验表明,添加中草药的试验组小肠上皮内淋巴细胞数显著多于对照组,且浓度高的效果好。由此显示了中草药可有效对抗热应激,提高蛋鸡生理机能。

  17. Effect of compound Chinese herbal medicine additive on the growth performance of big bone chicken%复方中草药添加剂对大骨鸡生长性能的影响

    Institute of Scientific and Technical Information of China (English)

    刘会娟

    2012-01-01

    研究复方中草药添加剂对大骨鸡生长性能的影响,选用1日龄大骨鸡200只,随机分为4组,每组50只,Ⅰ组为空白对照组,Ⅱ、Ⅲ、Ⅳ组基础日粮中分别添加0.5%、1%、2%复方中草药添加剂,试验期42d。在不同试验阶段称量体重和耗料,计算平均日增重、耗料量及料重比。结果表明,在日粮中添加不同比例的复方中草药添加剂对其生长性能有提高趋势,添加量以l%为最佳。%:To study the effect of compound Chinese herbal of big bone chicken, 200 one-day-old birds were randomly I was given only basic diet as blank control, group Ⅱ-Ⅳ 0.5%,1% and 2% for continuous 42 days, respectively. The medicine additive on the growth performance divided into 4 groups with 5 in each. Group was supplemented the additive at a dose of average body weight gain, feed consumption and the feed/weight ratio were determined during the experiment. The results showed that compound Chinese herbal medicine additive could enhance the growth performance of big bone chicken with an optimal dosage of 1%.

  18. DPPH和FRAP法测定41种中草药抗氧化活性%Determination of Antioxidative Activity of 41 Kinds of Chinese Herbal Medicines by Using DPPH and FRAP Methods

    Institute of Scientific and Technical Information of China (English)

    陈玉霞; 刘建华; 林峰; 杜向党

    2011-01-01

    The antioxidative activities of 41 kinds of Chinese herbal medicines were determined and selected. The antioxidative substances were extracted from Chinese herbal medicines by 70 percent ethanol and omni ruptor. The spectrophotometric method was used to study the antioxidant activities of medicinal herbs by DPPH and FRAP methods. The results show that these kinds of medicinal herbs including Polygonum multiflorum, Rheum pamatum, Epimedium grandiforum, Ctataegus tifiga, Paeonia lactiflora, Comus officinalis have strong antioxidant activities. When the concentration is 10 mg/mL,the extracts from these six herbs reduce at least 70% of DPPH and the FRAP value of antioxidative capacity is more than 200,and the others have weaker antioxidative activity.%为了测定41种抗衰老中草药的抗氧化活性,筛选了抗氧化作用强的中草药.实验采用70%的乙醇作溶剂,超声细胞破碎仪对药物进行提取,抗氧化能力的测定使用分光光度计,应用DPPH和FRAP进行测定.通过测定41种中草药乙醇提取液对DPPH自由基的清除能力和FRAP值,表征其抗氧化能力.结果表明:何首乌、大黄、淫羊藿、山楂、白芍、山茱萸等在10 mg/mL的浓度下,对DPPH自由基的清除率超过70%,总抗氧化能力的FRAP值>200,抗氧化能力较强;其他药物也有不同程度的抗氧化活性,但作用较弱.

  19. SWOT Analysis and Strategy Research of Chinese Herbal Medicine GAP Bases Development in Liaoning Province%辽宁省中药材 GAP 基地发展的 SWOT 分析及战略选择

    Institute of Scientific and Technical Information of China (English)

    张雪; 谢明

    2015-01-01

    目的:促进辽宁省中药材 GAP 基地发展。方法:SWOT 分析法和多专家评定法。结果:SWOT 分析表明辽宁省中药材 GAP 基地优势和劣势相伴,机遇与挑战并存,唯有加大地区政府支持力度,提高制药企业对 GAP的认识,发展优势道地药材,才能推动辽宁省中药材 GAP 的高效发展。结论:判断出辽宁省中药材 GAP 基地发展应采取的战略类型是调整性争取型战略。%Objective:To promote the development of Chinese herbal medicine GAP base in Liaoning province.Methods:The SWOT analysis and multi-expert rating methods were applied in the research.Results:SWOT analysis showed that there existed the advantages and disadvantages,opportunities and challenges for the GAP bases in Liaoning.The Chinese herbal medicine GAP bases in Liaoning province could develop efficiently,only if the regional government supports were intensified,pharmaceutical companies ’ understanding to the GAP was improved and Liaoning-specific geoherbs were promoted.Conclusion:It is concluded that the strategy should take the type for strategic adjustment strategy.

  20. Effect of the additive of Chinese herbal medicine of the Promoting Growth Type on Growth Performance of Broilers%促生长型中草药添加剂对肉仔鸡生产性能的影响

    Institute of Scientific and Technical Information of China (English)

    朱延旭; 王占红; 张喜臣; 李长江; 于淼

    2012-01-01

    选用1日龄健康艾维茵肉仔鸡,采用单因素完全随机化试验设计,研究在饲料中添加促生长型中草药添加剂对肉仔鸡生产性能的影响。试验共设3个处理组,每个处理纽4个重复,每个重复100只。对照组喂基础日粮,试验I组和试验II组分别在相同基础日粮中添加0.75%和1%的促生长型中草药添加剂。结果表明,促生长型中草药添加剂可使1日龄艾维茵肉仔鸡在48个饲养日内死亡率降低3.5个百分点,单位鸡只平均增重和料重比分别提高3.53%(P〈0.05)和4.35%(P〈0.05)。%The main aim of the experiment was proved the feasibility of the Chinese herbal medicine on improvement production performance of broilers. The result indicated that the Chinese herbal medicine formulated by authors could decrease the mortality for 3.5 percentage points, improve the average gain of each chicken for 3.53%, and 4.35% for feed and weight ration for one-day-old Avian during forty -eight days.

  1. Catalytic discoloring spectrophotometry determination of trace element germanium in Chinese herbal medicine (herba hedyotis)%催化褪色光度法测定中草药白花蛇舌草中的微量锗

    Institute of Scientific and Technical Information of China (English)

    杨慧; 丁良; 张宝淋; 袁丽云; 董晓东

    2015-01-01

    目的:利用催化褪色光度法测定中草药白花蛇舌草中微量元素锗。方法用超声波清洗仪提取中草药白花蛇舌草中微量元素锗,并用催化褪色光度法测定锗元素的含量。研究痕量锗在稀硫酸介质中催化加速溴酸钾、过氧化氢与中性红之间的反应,建立催化光度法测定痕量锗的方法。结果本实验测得中草药白花蛇舌草中无机锗(Ⅳ)含量为0.0248μg/g。结论该法灵敏度、精密度均能满足检测工作的需要。%Objective To explore a catalytic spectrophotometic method for the quantitative determination of trace elements germanium in Chinese herbal medicine (herba hedyotis).Methods Extraction of trace element germanium inherba hedyotis was examined by using ultrasonic cleaning equipment, and the content was determined by catalytic discoloring spectrophotometry. The reaction was studied, trace germanium (IV) could accelerate potassium bromate and hydrogen peroxide oxidize neutral red in H2SO4 medium, the established method could be used to determine catalytic spectrophotometric determination of trace germanium (IV).Results The results of this experiment indicated that inorganic germanium (IV) content in Chinese herbal medicine spreadingherba hedyotis was 0.024 8 μg/g.Conclusion The sensitivity, the precision can meet the needs of the testing work well.

  2. 提高中草药随机对照试验的质量Ⅲ:中草药的质量控制%Improving the quality of randomized controlled trials in Chinese herbal medicine, part Ⅲ: quality control of Chinese herbal medicine used in randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    梁士贤; 卞兆祥; David MOHER; Simon DAGENAIS; 李幼平; 刘良; 吴泰相; 缪江霞

    2006-01-01

    Objective: To discuss quality control of Chinese herbal medicine (CHM) in randomized controlled trials (RCTs), and to provide suggestions for improving this aspect in future clinical study in this therapeutic area. Methods: A search of the Cochrane Library was conducted to identify RCTs of CHM. Quality control information reported in those RCTs was then assessed independently. Results: The search yielded a total of 167 RCTs of CHM for a variety of conditions. A total of 11 CHM preparations were used in those RCTs. Only one trial discussed quality control of the CHM interventions used. Issues affecting the safety and efficacy of CHM products used in RCTs were discussed including standardization of raw herbal materials, processing methods, screening for product contamination, and effects of combination products. Conclusion: The overall quality of reporting of RCTs of CHM was poor, reflecting the need for improvements in reporting future clinical trials in this area. Recommendations: To improve quality control of CHM used in RCTs in future, we recommend developing and implementing guidelines such as Good Agricultural Practice (GAP) for Chinesecrude drugs, and current Good Manufacturing Practice (GMP) specific to CHM products. Chemical analyses of individual herbs of CHM and combination products are also recommended to provide reference standards for quality control.%目的:通过对中草药临床随机对照试验中有关中草药质量控制的方法进行分析评价,探讨如何实施中草药临床试验的药物质量控制.方法:文献检索2005年7月前发表于Cochrane图书馆的中草药系统评价共11篇,包含167个中草药临床随机对照试验,实证分析中草药临床试验中有关中草药质量控制的方法.结果:在纳入分析的167个中草药临床随机对照试验中,所采用的中草药制剂类型共有11种,其中只有1个临床随机对照试验提及中药的质量控制方法.结论:在中草药临床随机对照试验过

  3. A Meta-analysis on the curative effects of Chinese herbal retention enema on radiation enteritis%中药保留灌肠治疗放射性直肠炎疗效的Meta分析

    Institute of Scientific and Technical Information of China (English)

    邹文爽; 安颂歌; 熊壮; 池海勇; 刘铁军

    2015-01-01

    目的:应用Meta分析方法评价中药保留灌肠治疗放射性直肠炎的疗效。方法计算机检索The Cochrane Library、PubMed、EMbase、EBSCO、ISI、CNKI、VIP、WanFang Data和CBM数据库中关于中药保留灌肠治疗放射性直肠炎的随机对照试验,并追溯纳入文献的参考文献,检索时限均从建库至2014年5月。由2名研究者按照纳入排除标准独立进行文献筛选、资料提取、质量评价并交叉核对后,采用RevMan5.3软件进行Meta分析。结果纳入25个随机对照试验,其中进行Meta分析的有21个共1575例患者。 Meta分析显示,干预14 d后[RR=1.25,95%CI(1.10,1.42),P=0.0006]、20 d后[RR=1.19,95%CI(1.08,1.32),P=0.0007]、28 d后[RR=1.37,95%CI(1.21,1.54),P<0.00001]、30 d后[RR=1.63,95%CI (1.32,2.01),P<0.00001]中药保留灌肠治疗放射性直肠炎的总有效率高于对照组;干预10 d后[RR=1.23,95%CI=(0.93,1.63),P=0.15]、60 d后[RR=1.22,95%CI(0.94,1.56),P=0.13]中药保留灌肠治疗放射性直肠炎的总有效率与对照组相比差异无统计学意义。结论对放射性直肠炎患者实施中药保留灌肠干预2周以上能提高治疗的总有效率,减轻临床症状。但仍需要大样本、高质量的临床试验做进一步研究,观察长期效果。%Objective It is to evaluate the effect of Chinese herbal retention enema on radiation enteritis using Meta-anal-ysis method.Methods The Cochrane Library, PubMed, EMbase, EBSCO, ISI, CNKI, VIP, WanFang Data and CBM data-bases were searched to collect the randomized controlled trials ( RCTs) from the inception to May, 2014 about Chinese herbal retention enema on radiation enteritis, and the references of the included literature were also retrieved.Two reviewers inde-pendently screened the literatures according to the inclusion and exclusion criteria

  4. Study and application of herbal disinfectants in China.

    Science.gov (United States)

    Chen, Zhao-Bin

    2004-12-01

    Disinfection means killing or removing pathogenic microorganisms in media to realize a harmless process. A disinfectant, which is also referred to as a disinfection medicine in relevant regulations, is the medicine used to kill microorganisms for the purpose of disinfection. The disinfectants prepared from plants (including traditional Chinese herbal medicines) and the extracts thereof are called herbal disinfectants. China has a long history of using herbal disinfectants. As early as in 533 A.D., the use of Cornel to sterilize well water was recorded in Necessary Techniques for Qi People by Jia Enxie of the Beiwei Dynasty. During the Dragon Boat Festival, people often use fumigants made of traditional Chinese herbal medicines like Chinese Atractylodes, Argy Wormwood Leaf and Red Arsenic Sulfide to smoke their houses, so as to ward off plagues and drive away evils. In fact this is now a kind of disinfection practice. PMID:15745254

  5. Study and application of herbal disinfectants in China.

    Science.gov (United States)

    Chen, Zhao-Bin

    2004-12-01

    Disinfection means killing or removing pathogenic microorganisms in media to realize a harmless process. A disinfectant, which is also referred to as a disinfection medicine in relevant regulations, is the medicine used to kill microorganisms for the purpose of disinfection. The disinfectants prepared from plants (including traditional Chinese herbal medicines) and the extracts thereof are called herbal disinfectants. China has a long history of using herbal disinfectants. As early as in 533 A.D., the use of Cornel to sterilize well water was recorded in Necessary Techniques for Qi People by Jia Enxie of the Beiwei Dynasty. During the Dragon Boat Festival, people often use fumigants made of traditional Chinese herbal medicines like Chinese Atractylodes, Argy Wormwood Leaf and Red Arsenic Sulfide to smoke their houses, so as to ward off plagues and drive away evils. In fact this is now a kind of disinfection practice.

  6. Overview STUDY AND APPLICATION OF HERBAL DISINFECTANTS IN CHINA

    Institute of Scientific and Technical Information of China (English)

    ZHAO-BIN CHEN

    2004-01-01

    Disinfection means killing or removing pathogenic microorganisms in media to realize a harmless process. A disinfectant, which is also referred to as a disinfection medicine in relevant regulations, is the medicine used to kill microorganisms for the purpose of disinfection. The disinfectants prepared from plants (including traditional Chinese herbal medicines) and the extracts thereof are called herbal disinfectants[1]. China has a long history of using herbal disinfectants. As early as in 533 A.D., the use of Cornel to sterilize well water was recorded in Necessary Techniques for Qi People by Jia Enxie of the Beiwei Dynasty[2]. During the Dragon Boat Festival, people often use fumigants made of traditional Chinese herbal medicines like Chinese Atractylodes, Argy Wormwood Leaf and Red Arsenic Sulfide to smoke their houses, so as to ward off plagues and drive away evils[3]. In fact this is now a kind of disinfection practice.

  7. Simultaneous quantification of 50 bioactive compounds of the traditional Chinese medicine formula Gegen-Qinlian decoction using ultra-high performance liquid chromatography coupled with tandem mass spectrometry.

    Science.gov (United States)

    Wang, Qi; Song, Wei; Qiao, Xue; Ji, Shuai; Kuang, Yi; Zhang, Zheng-Xiang; Bo, Tao; Guo, De-An; Ye, Min

    2016-07-01

    The quality evaluation of patent drugs derived from traditional Chinese medicine (TCM) compound formulas has been challenging due to their complex chemical composition. In this study, we developed a solution to evaluate the quality of Gegen-Qinlian Decoction (GQD), an ancient four-herb TCM formula for the treatment of diarrhea and diabetes, together with its derived patent drugs by simultaneously quantifying 50 bioactive compounds. The samples were extracted by 100% methanol (for hydrophobic compounds) and 50% methanol in water (for hydrophilic compounds), respectively, and were separated on a Waters Acquity charged surface hybrid C18 column (2.1×100mm, 1.7μm) eluted with gradients of acetonitrile and water containing 0.1% formic acid at a flow rate of 400μL/min. The analytes were determined by ultra-high performance liquid chromatography coupled with tandem mass spectrometry in the selected reaction monitoring mode. The 50 compounds (including acidic and alkaline, hydrophilic and hydrophobic) were well resolved within 14min, and were determined using an internal standard method. The method was fully validated for precision, repeatability, and recovery. The limits of detection were 0.3-10.0ng/mL. Finally, this method was used to analyze 24 batches of GQD samples, including water decoction, pills, tablets, and oral solutions. Principal component analysis indicated significantly varied chemical compositions among these formulations. The tablets and pills contained higher concentrations of Scutellaria and Coptis compounds than the oral solutions, and the water decoction contained abundant glycosides and saponins. Moreover, the contents of flavanones and flavone O-glucuronides varied remarkably. This study provides a feasible solution for the comprehensive quality control of TCM patent drugs. PMID:27262372

  8. Management and application of Chinese herbal pieces of small package in the medicine chamber%小包装中药饮片在煎药室的管理与应用探讨

    Institute of Scientific and Technical Information of China (English)

    孙园园; 刘灿坤

    2013-01-01

    Objective: To discuss the management and application of Chinese herbal pieces of small package in the medicine chamber, especially the safety of toxic, medicine thing in the medicine chamber. Methods:According to the ministry of health, the State Administration of traditional Chinese medicine formulation of the “medical institutions of traditional Chinese medicine decocting room management norms”, combined with the actual work experience, the development of management measures and the application of the method to improve the. Results:Through the improvement of management and application of Chinese herbal pieces of small package, can determine the medicine further check and identification, especially for dose verification more direct reality, particularly conducive to the further management of poisonous hemp medicine. Conclusion:Chinese herbal pieces of small package is conducive to the management in the medicine chamber and the application of more perfect and reasonable. The utility model has the advantages of convenient: The medicine check and identification and medicine dose verification, to retain the medicine name, dose of the original packaging, for reference;enhance the toxicity of medicine, further management means; disadvantages: packaging bag (white) pollution (also recyclable) and economic costs, increased demolition charge time.%  目的:探讨小包装中药饮片在煎药室管理应用中更加完善合理性,尤其毒、麻药物在煎药室的安全性。方法:参照卫生部、国家中医药管理局制定的《医疗机构中药煎药室管理规范》等文件,结合实际工作经验,制定完善的管理措施和应用方法。结果:通过完善小包装中药饮片管理与应用,可进一步的明确药物的查对及鉴别,尤其对剂量核查更加直接现实,特别有利于对毒、麻药物的进一步管理。结论:小包装中药饮片有利于在煎药室管理与应用中更加完善合理。其优

  9. 论实践教学过程中学生中药辨识技能的培养%Cultivation of the Students'Identification Skills of Chinese Herbal Medicine in Pratical Teach-ing

    Institute of Scientific and Technical Information of China (English)

    罗堃; 严建业; 杨岩涛; 彭买姣; 夏新华; 彭江丽; 郭锦明; 焦懿

    2014-01-01

    中药作为中医防病治病的主要武器,药材之真伪、优劣,关系到临床用药之安全、疗效。因此,中药辨识是一切中药生产、应用、研究至关重要的第一步。我校对接中医药产业培育人才,通过合理配置硬件、软件教学资源,形成一个课内外、校内外联动的实践教学机制,为学生创造自主学习、自我训练的良好条件。在学生实践教学过程中,以传统的中药鉴别经验为基础,结合动植物分类学知识及现代鉴别手段,重点加强学生对中药材的基源、性状、显微、理化四大鉴定的实践技能训练,培养他们快速鉴别中药材真伪优劣的能力,为学生今后从事中药材种植、加工、经营、使用、检验、科研等相关工作奠定坚实基础。%As Traditional Chinese Medicine (TCM) is a main way to prevent and cure diseases , the quality of the medicine matters a lot to the safety and efficacy of clinical medication .Therefore , traditional Chinese medicine identification is crucial to the production , application, research of all Chinese medicine .Hunan University of TCM relates TCM industry to talent cultivation and develops a prac -tice teaching mechanism that combines teaching in and outside the class as well as in and outside the campus ., which provides the students with a good environment of self -learning and self-training.Practice teaching of Chinese medicine in our university is based on traditional identification experience of Chinese medicine , combines the knowledge of animal and plant taxonomy with modern identi-fication method .All of these contribute to helping the students develop the ability of identifying the quality of Chinese medicine quickly and lays a solid foundation for such related work as Chinese herbal medicine planting , medicine processing , medicine management , medicine use,medicine inspection, and its scientific research.

  10. Network pharmacology dissection of multiscale mechanisms of herbal medicines in stage IV gastric adenocarcinoma treatment.

    Science.gov (United States)

    Gao, Li; Hao, Jian; Niu, Yang-Yang; Tian, Miao; Yang, Xue; Zhu, Cui-Hong; Ding, Xiu-Li; Liu, Xiao-Hui; Zhang, Hao-Ran; Liu, Chang; Qin, Xue-Mei; Wu, Xiong-Zhi

    2016-08-01

    Increasing evidence has shown that Chinese Herbal Medicine (CHM) has efficient therapeutic effects for advanced gastric adenocarcinoma, while the therapeutic mechanisms underlying this treatment remain unclear.In this study, the Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of CHM treatment, and correlation analysis was applied to identify the most effective components in the formulas. A network pharmacological approach was developed to decipher the potential therapeutic mechanisms of CHM.CHM treatment was an independent protective factor. The hazard ratio was 0.364 (95% CI 0.245-0.540; P components in these formulas. Bioinformatics analyses suggested that the simultaneous manipulation of multiple targets in proliferation pathways (such as epidermal growth factor receptor, fibroblast growth factor receptor 2, human epidermal growth factor receptor 2, proliferating cell nuclear antigen, and insulin like growth factor 2) and the process of cancer metastasis (collagen families, fibronectin 1 and matrix metalloproteinases families) might largely account for the mechanisms of the 13 herbs against gastric adenocarcinoma.A network pharmacology method was introduced to decipher the underlying mechanisms of CHM, which provides a good foundation for herbal research based on clinical data. PMID:27583849

  11. Perspectives on the Pros and Cons of the Comprehensive Outpatient Pharmacy Management Pattern for Chinese Herbal Pieces Department%我院门诊实行综合药房管理模式后中药饮片部的得失与思考

    Institute of Scientific and Technical Information of China (English)

    彭洪兴; 蔡楚兰

    2009-01-01

    OBJECTIVE: To explore the management pattern that conducive to the development of the Chinese Herbal Pieces Department. METHODS: The pros and cons of the comprehensive pharmacy management pattern for Chinese Herbal Pieces Department were analyzed. RESULTS: The introduction of the comprehensive pharmacy management pattern in the Chinese Herbal Pieces Department resulted in the reduction of the human, material and financial resources; however, it also led to declining of the quality of the cut crude drug, reduction in drug consumption, lowering of pharmacists' sense of responsi-bility, presence of more risk factors of dispensing errors, lowering of social concern, weakening of the position of Chinese medicine and marginalization of status of Chinese medicine. CONCLUSION: The inclusion of Chinese Herbal Pieces Department into comprehensive pharmacy management should be carried out with prudence or it might as well to maintain the relative independence of the Chinese Herbal Pieces Department so as to protect and develop the Chinese medicine.%目的:探讨利于门诊药房中药饮片部发展的管理模式.方法:分析在综合药房管理模式下中药饮片部的利弊得失.结果:中药饮片部纳入综合药房管理模式后,虽然减少了人力、物力、财力的占用,但导致饮片养护质量下降,销售量减少,药师责任心降低,发生调配差错的因素增加,社会关注度降低,中医药事业阵地被弱化,地位被边缘化.结论:从保护和发展中医药事业目的出发,将中药饮片部纳入综合药房管理时应慎重,或仍以保持其相对独立性为宜.

  12. Triphala: The Thai traditional herbal formulation for cancer treatment

    OpenAIRE

    Ariyaphong Wongnoppavich; Kanjana Jaijoi; Seewaboon Sireeratawong

    2009-01-01

    Nowadays, Thai herbal plants are widely accepted in alternative medicine for treatment patients suffering deleterious diseases such as cancer. Having a variety of indications, several herbal formulas including Triphala have been routinely used as health tonic in Thai traditional and Ayurvedic medicines. The formulation of Triphala is a mixture of fruits of three plants: Phyllanthus emblica Linn., Terminalia chebula Retz. and Terminalia bellerica (Gaertn.) Roxb., all of which were reported to ...

  13. Isolation of Cronobacter sakazakii from different herbal teas

    OpenAIRE

    Stojanović Marija M.; Katić Vera; Kuzmanović Jelena

    2011-01-01

    Bacground/Aim. Cronobacter sakazakii (C. sakazakii) is an emerging food-borne pathogen that has increasingly raised interest among the whole public community and food industry, especially in the production of powder infant formula. It has been isolated from water, sediment and soil. The question is whether this pathogen can be present in herbal teas. Herbal teas are widely used for great number of health problems, as an additional or sometimes only “medicine” given. The aim of this stud...

  14. Chinese Herbal Medicine Combined with Conventional Therapy for Blood Pressure Variability in Hypertension Patients: A Systematic Review of Randomized Controlled Trials

    Directory of Open Access Journals (Sweden)

    Zhuo Chen

    2015-01-01

    Full Text Available Objective. The aim of this systematic review is to evaluate effect of Chinese medicine combined with conventional therapy on blood pressure variability (BPV in hypertension patients. Methods. All randomized clinical trials (RCTs comparing Chinese medicine with no intervention or placebo on the basis of conventional therapy were included. Data extraction, analyses, and quality assessment were performed according to the Cochrane standards. Results. We included 13 RCTs and assessed risk of bias for all the trials. Chinese medicine has a significant effect in lowering blood pressure (BP, reducing BPV in the form of standard deviation (SD or coefficient of variability (CV, improving nighttime BP decreased rate, and reversing abnormal rhythm of BP. Conclusions. Chinese medicine was safe and showed beneficial effects on BPV in hypertension patients. However, more rigorous trials with high quality are warranted to give high level of evidence before recommending Chinese medicine as an alternative or complementary medicine to improve BPV in hypertension patients.

  15. 单味中药对兔球虫卵囊孢子化抑制效果的研究%Suppression Effect of Single Chinese Herbal Medicine on the Sporulating of Rabbit Coccidia Oocysts

    Institute of Scientific and Technical Information of China (English)

    高俊峰; 王卓林; 侯美如; 李桂伟; 王丽坤

    2014-01-01

    To investigate the inhibition effect of the different concentration of single Chinese herbal medicine on the sporulating of rabbit coccidia oocysts at different times,a series of experiments were performed. Firstly,Under the same concentration culture conditions,the sporulated rate of rabbit coccidia oocysts gradually went up with time in all choosed Chinese herbal medicin,except for fructus bruceae. In other words,suppression effect of fructus bruceae was significant,and herba agrimoniae,radix dichroae,herba artemisiae annuae,herba verbenae,fructus quisqualis,radix bupleuri had a certain suppression effect. Then Chinese herbal medicine was washed and cultured for 3 days,and the sporulated rate of rabbit coccidia oocysts had been on the rise in all groups,which showed that some Chinese herbs had some certain suppression effect on the sporulating of rabbit coccidia oocysts,but they did not effectively eliminate the oocysts. Additionally,inhibition test was performed under different concentration culture conditions.The results showed that the sporulated rate of oocysts were changed significantly with increase in the concentration by herba agrimoniae, radix dichroae,herba artemisiae annuae and fructus bruceae,especially the suppression effect of 100% concentration was better than 50% and 25%. By contrast,the sporulated rate of oocysts increased were not significantly with the above concentration by herba verbenae,fructus quisqualis and radix bupleuri.%研究单味中药在不同时间及不同浓度下对兔球虫卵囊孢子化抑制效果。首先,在同浓度单味中药培养的条件下进行观察,发现随着时间的延长,除鸦胆子中卵囊孢子化率没有升高外,其余中药球虫卵囊孢子化率均有不同程度的升高;鸦胆子对兔球虫卵囊孢子化有显著的抑制作用,仙鹤草、常山、青蒿、马鞭草、使君子和柴胡有一定的抑制作用;各组洗去中药继续培养3 d,发现各组卵囊孢子化率均

  16. Extracting Active Component from Extractive Residue of Chinese Herbal Medicine%植物药提取废渣中再次提取有效成分的研究

    Institute of Scientific and Technical Information of China (English)

    杨威; 王丽; 王玮; 车春波; 李俊生; 左金龙

    2014-01-01

    Extracting active component from Chinese herbal medicine extractive residue which came from a traditional Chinese medicine plant was carried out by means of microwave-assisted extraction and the technique was compared with the traditional one (aqueous extraction). In order to discuss the recycle value of extracting from the extracted Chinese herbal residue, and to seek for the efficient path for recycling of Chinese herbal residue, the process for extracting baicalin was optimized with using yield of baicalin as the investigation index by means of single factor analysis and orthogonal experiments. The results showed influence factors on baicalin yield as follows(form great to less):ethanol concentration>granularity of ex-tractive residue>microwave power>duration of microwave irradiation. And the ethanol concentration was the significant influencing factor. The opti-mal parameters were obtained as follows:30%ethanol was chosen as the extraction solvent;the microwave power was 500W;the granularity of the ex-traction residue was 80 meshes;the duration of microwave irradiation was 2min. The higher yield of baicalin could be achieved by microwave-assisted extraction.%利用微波萃取技术针对某中药厂双黄连制剂生产过程中产生的废弃黄芩提取药渣进行了有效成分的再次提取并同传统水提工艺进行了对比。以有效成分(黄芩苷)收率做为考察指标,用正交设计结合单因素分析方法考察微波提取黄芩苷的最佳提取条件,旨在探讨植物药提取废渣的再利用价值、探寻植物药提取废渣资源化的有效途径。结果表明:各因素对黄芩苷收率的影响依次为:乙醇浓度>粒径>功率>提取时间,其中乙醇浓度为显著性影响因素,最佳工艺为:以30%乙醇作为提取溶剂,黄芩药渣粒径80目,微波功率选择500W,微波提取2min。与水提工艺相比,在最佳工艺条件下,微波提取工艺能够获得较高收率的黄芩苷。

  17. Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway.

    Science.gov (United States)

    Liu, Jun-Shan; Wei, Xi-Duan; Lu, Zi-Bin; Xie, Pei; Zhou, Hong-Ling; Chen, Yu-Yao; Ma, Jia-Mei; Yu, Lin-Zhong

    2016-04-19

    Liang-Ge-San (LGS) is a classic formula in traditional Chinese medicine, which is widely used to treat acute lung injury (ALI), pharyngitis and amygdalitis in clinic. However, the underlying mechanisms remain poorly defined. In this study, we discovered that LGS exerted potent anti-inflammatory effects in lipopolysaccharide (LPS)-induced inflammation. We found that LGS significantly depressed the production of IL-6 and TNF-α in LPS-stimulated RAW 264.7 macrophage cells. The degradation and phosphorylation of IκBα and the nuclear translocation of NF-κB p65 were also inhibited. Moreover, LGS activated α7 nicotinic cholinergic receptor (α7nAchR). The blockage of α7nAchR by selective inhibitor methyllycaconitine (MLA) or α7nAchR siRNA attenuated the inhibitory effects of LGS on IκBα, NF-κB p65, IL-6 and TNF-α. Critically, LGS significantly inhibited inflammation in LPS-induced ALI rats through the activation of NF-κB signaling pathway. However, these protective effects could be counteracted by the treatment of MLA. Taken together, we first demonstrated anti-inflammatory effects of LGS both in vitro and in vivo through cholinergic anti-inflammatory pathway. The study provides a rationale for the clinical application of LGS as an anti-inflammatory agent and supports the critical role of cholinergic anti-inflammatory pathway in inflammation.

  18. Identification and Quantitative Characterization of PSORI-CM01, a Chinese Medicine Formula for Psoriasis Therapy, by Liquid Chromatography Coupled with an LTQ Orbitrap Mass Spectrometer

    Directory of Open Access Journals (Sweden)

    Shao-Dan Chen

    2015-01-01

    Full Text Available PSORI-CM01 is a Chinese medicine formula prepared from medicinal herbs and used in China for the treatment of psoriasis. However, the chemical constituents in PSORI-CM01 have not been clarified yet. In order to quickly define the chemical profiles and control the quality of PSORI-CM01 preparations, ultra-high liquid chromatography coupled with electrospray ionization hybrid linear trap quadrupole Orbitrap mass spectrometry (UHPLC-ESI-LTQ/Orbitrap-MS was applied for simultaneous identification and quantification of multiple constituents. A total of 108 compounds, including organic acids, phenolic acids, flavonoids, and terpenoids, were identified or tentatively deduced on the base of their retention behaviors, MS and MSn data, or by comparing with reference substances and literature data. In addition, an optimized UHPLC-ESI-MS method was established for the quantitative determination of 14 marker compounds in different dosage forms of PSORI-CM01 preparations. The validation of the method, including spike recoveries, linearity, sensitivity (LOQ, precision, and repeatability, was carried out and demonstrated to be satisfied the requirements of quantitative analysis. This is the first report on the comprehensive determination of chemical constituents in PSORI-CM01 preparations by UHPLC-ESI-LTQ/Orbitrap mass spectrometry. The results suggested that the established methods would be a powerful and reliable analytical tool for the characterization of multi-constituents in complex chemical system and quality control of TCM preparations.

  19. Identification of chemical constituents in two traditional Chinese medicine formulae by liquid chromatography-mass spectrometry and off-line nuclear magnetic resonance.

    Science.gov (United States)

    Wang, Shufang; Zhu, Yunxiang; Shao, Qing; Wang, Yi; Fan, Xiaohui; Cheng, Yiyu

    2016-01-01

    There have been increasing works on identification of the chemical constituents in traditional Chinese medicines (TCMs) by liquid chromatography-mass spectrometry (LC-MS). However, isomers cannot be distinguished generally only by MS data, and the structures of unknown compounds cannot be confirmed. In this study, semi-preparative LC guided by LC-MS was used to prepare the isomers in microscale followed by off-line NMR analysis to confirm their structures. This approach was applied to identifying the constituents in two TCM formulae, Zhi-Zi-Gan-Cao-Chi-Tang (ZZGCCT) and Zhi-Zi-Bai-Pi-Tang (ZZBPT). A total number of 119 constituents were identified tentatively or unambiguously by LC-IT-MS, LC-Q-TOF-MS, and NMR. Among them, 20 constituents were characterized unambiguously by comparing with the reference substances. In addition, 21 constituents without reference substances were prepared for the following 1D-NMR and/or 2D-NMR analysis, and their structures were unambiguously identified by MS, 1D-NMR, and 2D-NMR. Two triterpenoid glycosides (compounds 134 and 140) and one flavonoid glycoside (compound 62a or 62b) were showed to be novel compounds. Compounds 125 and 129, as well as 62a,b, were epimers.

  20. Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway.

    Science.gov (United States)

    Liu, Jun-Shan; Wei, Xi-Duan; Lu, Zi-Bin; Xie, Pei; Zhou, Hong-Ling; Chen, Yu-Yao; Ma, Jia-Mei; Yu, Lin-Zhong

    2016-04-19

    Liang-Ge-San (LGS) is a classic formula in traditional Chinese medicine, which is widely used to treat acute lung injury (ALI), pharyngitis and amygdalitis in clinic. However, the underlying mechanisms remain poorly defined. In this study, we discovered that LGS exerted potent anti-inflammatory effects in lipopolysaccharide (LPS)-induced inflammation. We found that LGS significantly depressed the production of IL-6 and TNF-α in LPS-stimulated RAW 264.7 macrophage cells. The degradation and phosphorylation of IκBα and the nuclear translocation of NF-κB p65 were also inhibited. Moreover, LGS activated α7 nicotinic cholinergic receptor (α7nAchR). The blockage of α7nAchR by selective inhibitor methyllycaconitine (MLA) or α7nAchR siRNA attenuated the inhibitory effects of LGS on IκBα, NF-κB p65, IL-6 and TNF-α. Critically, LGS significantly inhibited inflammation in LPS-induced ALI rats through the activation of NF-κB signaling pathway. However, these protective effects could be counteracted by the treatment of MLA. Taken together, we first demonstrated anti-inflammatory effects of LGS both in vitro and in vivo through cholinergic anti-inflammatory pathway. The study provides a rationale for the clinical application of LGS as an anti-inflammatory agent and supports the critical role of cholinergic anti-inflammatory pathway in inflammation. PMID:27034013

  1. The combination of aricept with a traditional Chinese medicine formula, smart soup, may be a novel way to treat Alzheimer's disease.

    Science.gov (United States)

    Wang, Ying; Wang, Ying; Sui, Yi; Yu, Hongshuang; Shen, Xiaoheng; Chen, Shengdi; Pei, Gang; Zhao, Jian; Ding, Jianqing

    2015-01-01

    Alzheimer's disease (AD) is a common neurodegenerative disease affecting cognitive function in the elderly, which is characterized by the presence of extracellular deposits of insoluble amyloid-β plaques and neuronal loss. Modern pharmacology and drug development usually follow a single-target principle, which might contribute to the failure of most compounds in clinical trials against AD. Considering AD is a multifactorial disease, a combination therapeutic strategy that applies drugs with different mechanisms would be an alternative way. Smart Soup (SS), a Traditional Chinese Medicine formula, is composed of three herbaceous plants and has been applied in the treatment of amnesia in China for hundreds of years. In this work, we studied the clinical potency of the combination of SS and Aricept in AD therapy. In the in vivo model, both longevity and locomotive activity of AD transgenic Drosophila were improved remarkably in the combined medicine treated group. We also observed less amyloid-β deposition and retarded neuronal loss following the combined drug treatment. In the retrospective cohort study, we found the combination therapy exerted better therapeutic effect on AD patients. Our study revealed that combination therapy with multiple drug targets did have a better therapeutic outcome. It provides a new strategy to develop an optimum pharmaceutical approach against AD.

  2. The politics of herbal drugs in Korea.

    Science.gov (United States)

    Cho, B H

    2000-08-01

    Hanbang, the Korean medical practice with origins in classical Chinese texts, is a prominent part of the Korean health care system. Hanbang physicians, called hanuisas, are looked down on by biomedical doctors, but their practice has enjoyed increasing popularity for several decades. As the market for herbal preparations has become more lucrative, biomedical pharmacists have begun to participate in it. The Pharmaceutical Act in 1993 explicitly allowed pharmacists to prescribe and dispense herbal drugs. This provoked a bitter public conflict between hanuisas and pharmacists, involving street demonstrations and strikes. The hanuisas asserted that the pharmacists were unqualified to assume their traditional practice. They also agitated for recognition in the state-sponsored system of health care and for the state's support for developing Hanbang medicine. This paper attributes the conflicts concerning Hanbang to the expanding market for herbal preparations, Korean nationalism, and to the oversupply of biomedical pharmacists. PMID:10868666

  3. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis

    OpenAIRE

    Xiao-na Zhang; Ze-jun Ma; Ying Wang; Yu-zhu Li; Bei Sun; Xin Guo; Cong-qing Pan; Li-ming Chen

    2015-01-01

    Impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited effective treatments. Tuo-Li-Xiao-Du-San (TLXDS), a traditional Chinese medicine formula for refractory wounds, has been prescribed for nearly 400 years in China and shows good efficacy in promoting healing. In this study, we explored the effect of TLXDS on healing of diabetic wounds and investigated underlying mechanisms. Four weeks after intravenous injection of st...

  4. Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa–induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways

    OpenAIRE

    Yuanyuan Hou; Yan Nie; Binfeng Cheng; Jin Tao; Xiaoyao Ma; Min Jiang; Jie Gao; Gang Bai

    2016-01-01

    Gram-negative pathogen–induced nosocomial infections and resistance are a most serious menace to global public health. Qingfei Xiaoyan Wan (QF), a traditional Chinese medicine (TCM) formula, has been used clinically in China for the treatment of upper respiratory tract infections, acute or chronic bronchitis and pulmonary infection. In this study, the effects of QF on Pseudomonas aeruginosa–induced acute pneumonia in mice were evaluated. The mechanisms by which four typical anti-inflammatory ...

  5. Safety Evaluation of Local Weight-Gain Formulas in the Saudi Arabian Markets

    Directory of Open Access Journals (Sweden)

    Nora Abdullah ALFaris

    2015-01-01

    Full Text Available Background. The utilization of herbal formulas is continuously increasing on the global level. However, assessment of contamination and impurities is the leading challenge in the use of herbal medicines. Objective. Assessment of therapeutic application in relation to herbal formulas usage for reducing weight is the objective for this investigation. Results. Reduced dietary fibers and fats are common outcomes of herbal usage. 9.8% of the mixtures were contaminated because of lead. However, investigation has indicated <10 microbial counts in herbal products. Increased levels of calcium, minerals, fibers, and lead traces have been identified in the herbals; however, products lacked nicotinamide, riboflavin, and vitamin C. Conclusion. It was concluded that majority of herbal products were pure and uncontaminated in order to reduce the complications of obesity efficiently.

  6. Infant formula.

    Science.gov (United States)

    O'Connor, Nina R

    2009-04-01

    Although the American Academy of Pediatrics and the American Academy of Family Physicians recommend breast milk for optimal infant nutrition, many parents still choose formula as an acceptable alternative. The wide variety of available formulas is confusing to parents and physicians, but formulas can be classified according to three basic criteria: caloric density, carbohydrate source, and protein composition. Most infants require a term formula with iron. There is insufficient evidence to recommend supplementation with docosahexaenoic acid or arachidonic acid. Soy formulas are indicated for congenital lactase deficiency and galactosemia, but are not recommended for colic because of insufficient evidence of benefit. Hypoallergenic formulas with extensively hydrolyzed protein are effective for the treatment of milk protein allergy and the prevention of atopic disease in high-risk infants. Antireflux formulas decrease emesis and regurgitation, but have not been shown to affect growth or development. Most infants with reflux require no treatment. Family physicians can use these guidelines to counsel parents about infant formula, countering consumer advertising that is not evidence-based. PMID:19378873

  7. 复方中草药制剂对肉仔鸡生产性能和抗氧化功能影响的研究%Effect of Chinese herbal prescription on production performance and antioxidant activity of broilers

    Institute of Scientific and Technical Information of China (English)

    傅帅; 轩振; 李鸿博; 马春阳; 李文强; 史东辉

    2016-01-01

    研究由牛至、甘草、连翘、金银花和黄芪等药材组成的中草药制剂对肉仔鸡生产性能和抗氧化性能的影响.选用1 日龄同批孵化AA+肉仔鸡2 000 只,采用单因子试验设计,随机分为5 个日粮处理,每个处理8 个重复,每个重复50 只鸡,公、母各半.基础日粮为玉米-豆粕型,第Ⅰ组为对照组饲喂基础日粮,试验Ⅱ组在基础日粮中添加抗生素(恩拉霉素10 g/t,硫酸抗敌素20 g/t),试验Ⅲ、Ⅳ和Ⅴ组分别在基础日粮中添加 50、100 和 150 g/t的复方中草药制剂,试验期为42 d.结果表明:在22~42 d时,试验Ⅳ组与对照组相比显著改善了肉仔鸡平均日增重,饲料转化率提高;与对照组和抗生素组相比,试验Ⅳ组显著提高了 2 1 dAA+肉仔鸡的总抗氧化能力和超氧化物歧化酶活性;显著提高了4 2 dAA+肉仔鸡总抗氧化能力、超氧化物歧化酶和谷胱甘肽过氧化物酶活性,显著降低了血清丙二醛含量;显著降低了试验Ⅳ、Ⅴ组肌肉中丙二醛含量.日粮中添加100 g/t复方中草药制剂较适宜.%A 42 d trial was conducted with 2 000 broiler chickens to determine the effects of Chinese herbal prescription on antioxidant activity and growth performance of broilers.AA+ broilers at 1-day of age were randomly divided into five groups with 8 replicates each,per group according to a completely random design.The control group(group Ⅰ)was fed a corn-soy-bean meal based diet,the antibiotic group(groupⅡ)was fed a diet with enramycin 10 g/t and colistin sulfate 20 g/t,and groupsⅢ,Ⅳand Ⅴ were fed with 50,100 and 150 g/t of Chinese herbal prescription,respectively.The results showed that average daily gain and feed conversion in group Ⅳ had greater improvement at 22~42 d compared to the control group.The total an-tioxidant(T-AOC)capacity and superoxide dismutase(SOD)activity of broilers at 2 1-d of age in group Ⅳ increased significant-ly compared to the control and antibiotics groups

  8. 美国关于中药法律法规的历史沿革及展望%Development of US Federal Laws and Regulations Regarding Chinese Herbal Medicine:History and Outlook

    Institute of Scientific and Technical Information of China (English)

    陈涛

    2013-01-01

    Chinese medicine, categorized as the complementary and alternative medicine in the United States, is one of many kinds of traditional medicines. By far, no speciifc law or regulation is released in U.S. particularly aimed at the Chinese herbal medicine ( CHM ). The legal restriction and management for CHM were scattered in other different laws and regulations. The Guide for Botanical Drugs released in 2004 has opened a door for Chinese medicine into the American mainstream pharmaceutical market. The Chinese medicine enterprises should make full use of the guide, selecting some traditional Chinese medicine products that have remarkable curative effects and meet the FDA requirements, to complete their new drug applications in the United States and push them to the American pharmaceutical market as soon as possible. This article mainly studied the laws, regulations and policies regarding CHM published by US federal government and the Food and Drug Administration, analyzed their inlfuence on CHM development and investigated the developing trend of CHM in the U.S..%中医药在美国只是相对西药独立存在的多种传统医药的一种。为与西医进行区分,美国人将这些不同的医学统一称为补充与替代医学。迄今为止,美国尚无对中药管理的专门法律法规,对中药的要求分散在不同的法律法规中。2004年,美国颁发了《植物药物产品指南》,为以植物药为主的中药进入美国主流医药市场开启了一扇大门。我国中医药企业应充分利用《植物药物产品指南》,选择能够在较短时间内满足FDA相关要求并具有显著疗效的中药产品,完成中药在美国的新药申请并尽快上市。

  9. [Research on the citation of Herbal in Dongeuibogam].

    Science.gov (United States)

    Xiao, Yongzhi; Dang, Zhizheng

    2014-07-01

    Dongeuibogam is the most prestigious traditional medical book in Korea, written by Heo Joon, who codified it by picking the essence of Chinese traditional medical books before the Ming Dynasty and some other ancient Chinese books and sorted them out. Among the citations of this book, those marked as"Herbal" is more complicated. We made a preliminary research on the citations of such Herbal, from their distribution, sources, citation manners, pharmacological features, to find that 23 rolls of main text to include citations of Herbal in each roll. We also found that most Herbal referred by Heo Joon come from Zheng lei ben cao (Classified Materia Medica), and a few of the contents are mixed with the contents of other medical books. Heo Joon abstracted and modified the citations from the source literature, embodying his ideas of pursuing conciseness and practicability. PMID:25429883

  10. Makeham's Formula

    DEFF Research Database (Denmark)

    Astrup Jensen, Bjarne

    Makeham's formula is an actuarial formula expressing the present value of a payment stream in terms of its repayments instead of the payments themselves. The formula is largely neglected in the finance literature, but -- as this paper shows -- it has a number of useful applications in fixed income...... analysis. We use Makeham's formula to decompose the return on a bond investment into interest payments, realized capital gains and accrued capital gains for a variety of accounting rules for measuring accruals in order to study the theoretical properties of these accounting rules, their taxation...... consequences and their implications for the relation between the yield before tax and the yield after tax. We also show how Makeham's formula produces short-cut expressions for the duration and convexity of a bond and facilitates the analytical calculation of the yield in certain cases....

  11. Molecular mechanisms of renal extracellular matrix degradation and interventional effects of Chinese herbal medicine%肾脏细胞外基质降解的分子机制及中药的干预作用

    Institute of Scientific and Technical Information of China (English)

    魏晴雪; 万毅刚; 赵青; 陈好利; 孟宪杰; 姚建

    2013-01-01

    The reduction of extracellular matrix(ECM) degradation in kidney is taken as the morphological features and pathological base in renal injury in chronic kidney disease(CKD).ECM degradation is controlled by the catabolic enzyme systems in glomerulus and renal interstitium,in which matrix metalloproteinases(MMPs) play a key role.The expression and activity of MMPs are regulated by the classical pathway,such as the genic transcription,the activation of zymogen,and the specific inhibitor.The previous studies showed that,Uremic Clearance granule,as a representation,and other prescriptions of Chinese herbal medicine,as well as some extracts from Chinese herbal medicine could intervene the pathway of ECM degradation through promoting the degradation of ECM components,affecting the expression of catabolic enzymes,regulating the genetic transcription of MMPs,and inhibiting the relative signaling transduction of MMPs.%肾脏细胞外基质(extracellular matrix,ECM)降解减少是慢性肾脏病(chronic kidney disease,CKD)肾组织损伤的形态特征和病理基础.在肾小球或肾间质中,ECM降解主要依赖于降解酶系统的调控,其中,基质金属蛋白酶(matrix metalloproteinases,MMPs)发挥着核心作用.MMPs的表达和活性受控于“基因转录、酶原激活、特异性抑制剂”等经典途径.以尿毒清颗粒(Uremic Clearance granule)为代表的中药复方制剂及中药提取物可以干预ECM降解的多种途径,包括促进ECM成分降解,影响ECM降解酶表达、调节MMPs基因转录、抑制MMPs相关信号转导等.

  12. Clinical Research on Technique Combined with Chinese Herbal Fumigation in the Treatment of Knee Osteoarthritis%手法配合中药熏洗治疗膝骨性关节炎的临床研究

    Institute of Scientific and Technical Information of China (English)

    黄百光; 黄红; 孙红华

    2015-01-01

    Objective To investigate the clinical efficacy of technique combined with Chinese herbal fumigation in the treatment of knee osteoarthritis. Methods Clinical data of 100 cases of patients with knee osteoarthritis admitted to our hospital from February 2005 to May 2007 were retrospectively analyzed. All patients were randomly divided into observation group and control group, with 50 cases in each group. The control group was treated with oral voltaren and external diclofenac sodium gel, the observation group was treated with technique combined with Chinese herbal fumigation. The change of pain, activity range, initiative stretch restrict, walking ability, daily activity and arthroedema in two groups were compared, and the clinical effect was observed and compared. Results The scores of pain and walking ability, daily activity, initiative stretch restrict and arthroedema of two groups before treatment had no statistical difference (P>0.05). After treatment, the above indices of the two groups were improved, and the improvement degree of pain and walking ability, daily activity and initiative stretch restrict in the observation group were significantly better than those in the control group, with statistical difference (P0.05)。治疗后,两组患者以上指标得分均有所改善,且观察组疼痛和步行能力、日常活动以及主动伸展受限改善程度均显著优于对照组,差异具有统计学意义(P<0.05)。观察组临床总有效率为96.0豫,显著高于对照组的80.0豫,差异具有统计学意义(P<0.05)。结论手法配合中药熏洗治疗膝骨性关节炎,治疗效果持久稳定,不良反应少,值得推广应用。

  13. Comparison of a Chinese Herbal Medicine (CCH1 and Lactulose as First-Line Treatment of Constipation in Long-Term Care: A Randomized, Double-Blind, Double-Dummy, and Placebo-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Chien-Hsun Huang

    2012-01-01

    Full Text Available Many institutionalized patients and their healthcare providers are dissatisfied with current laxative therapy. This study compared therapeutic efficacy, safety, and laxative cost of an herbal formula (CCH1 and lactulose for long stay patients with constipation. In this double-blind, double-dummy, and placebo-controlled trial, we randomized 93 residents with chronic constipation from two long-term care facilities in Taiwan to receive either CCH1 with lactulose placebo or CCH1 placebo with lactulose for 8 weeks, then followed up for 4 weeks without study medication. Both treatments were effective and well tolerated for patients, but CCH1 produced more spontaneous bowel movements, less rectal treatments, less amount of rescue laxative, and lower laxative cost than lactulose during treatment. No significant differences were found in stool consistency, stool amount, global assessment, and safety concerns. In conclusion, our results suggest that CCH1 may have better efficacy and could be used as an alternative option to lactulose in the treatment of constipation in long-term care.

  14. Herbal medicine (Shaofu Zhuyu decoction) for treating primary dysmenorrhea: A systematic review of randomized clinical trials.

    Science.gov (United States)

    Lee, Hoyoung; Choi, Tae-Young; Myung, Chang-Seon; Lee, Ju Ah; Lee, Myeong Soo

    2016-04-01

    Shaofu Zhuyu decoction (SFZY) or Sobokchugeo-tang, a traditional herbal formula, is used as a treatment for primary dysmenorrhea. We searched four English, seven Korean, three Chinese, and one Japanese database from inception through January 2016 without a language restriction. All randomized controlled trials (RCTs) of SFZY or modified SFZY (MSFZY) were included. Data extraction and risk of bias assessments were performed by two independent reviewers. A total of 51 potentially relevant studies were identified, and 9 RCTs met our inclusion criteria. Seven RCTs tested the effects of SFZY or modified SFZY in treating dysmenorrhea. Three RCTs showed superior effects of (M)SFZY on the response rate, while the other three RCTs failed to do so (n=531, RR: 1.17, 95% CI: 1.09 to 1.26, Pdysmenorrhea. However, the level of evidence is low because of a high risk of bias. PMID:26921931

  15. Identification of chemical constituents in traditional Chinese medicine formula using HPLC coupled with linear ion trap-Orbitrap MS from high doses of medicinal materials to equivalent doses of formula: Study on Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules.

    Science.gov (United States)

    Wang, Fengyun; Zhang, Qingqing; Lu, Zhiwei; Wang, Qing; Wang, Meiling; Liu, Yuehong; Fu, Shuang; Gao, Xiaoyan; Tang, Xudong

    2016-05-01

    High-resolution mass spectrometry has been a powerful tool for the research of chemical constituents in traditional Chinese medicine (TCM) formulas. However, the chromatographic peaks were difficult to discriminate clearly in data collection or analysis because of the complexity and the greatly different content of the constituents in TCM formula, which increased the difficulty of identification. In this study, a high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry based strategy focused on the comprehensive identification of TCM formula constituents was developed. Identification was carried out from a high dose of medicinal materials to equivalent dose of formula. Meanwhile, combined with mass spectrometry data, chromatographic behaviors, reference standards and previous reports, the identification of constituents in Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules was described. 169 compounds were unambiguously or tentatively characterized, mainly including flavonoids, alkaloids, triterpenic acids, triterpene saponins, lactones, sesquiterpenoids and some other compounds. Among them, 11 compounds were unambiguously confirmed by comparing with reference standards. These results demonstrated that the method was effective and reliable for comprehensive identification of constituents of Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules extracts and reveal the material basis of its therapeutic effects. This strategy might propose a research idea for the characterization of multi-constituents in TCM formula. PMID:26935761

  16. Effects and Interaction of Icariin, Curculigoside, and Berberine in Er-Xian Decoction, a Traditional Chinese Medicinal Formula, on Osteoclastic Bone Resorption

    Directory of Open Access Journals (Sweden)

    Liming Xue

    2012-01-01

    Full Text Available Er-Xian decoction (EXD, a traditional Chinese medicine, has been reported to have a protective effect against bone loss in ovariectomized osteoporotic rats, and the inclusion of icariin (I, curculigoside (C, and berberine (B in EXD displays inhibitory effects on osteoclastic bone resorption. In the present paper, we investigated the interaction and effects of I, C, B, and their combination on bone resorption activity in vitro on osteoclasts derived from rat bone marrow cells. ICB synergistically decreased the formation of bone resorption pits, the number of multinucleated osteoclasts, and the activity of tartrate-resistant acid phosphatase (TRAP and showed antagonistic or additive effects on cathepsin K activity in the coculture system of osteoblasts and bone marrow cells in the presence of 1, 25-dihydroxyvitamin D3 and dexamethasone. The combination of ICB also enhanced the inhibitory effects on the formation of F-actin ring, a cytoskeleton structure of osteoclasts induced from bone marrow cells with macrophage colony stimulation factor (M-CSF and receptor activator of NF-κB ligand (RANKL. In addition, ICB synergistically improved the ratio of protein expression of osteoprotegerin (OPG and RANKL in osteoblasts and interfered with the mitogen-activated protein kinases (MAPKs pathway in osteoclast. These results clearly show that I, C, B, and their combination in EXD exert effects of mutual reinforcement. However, IBC does not show an intensified adverse effect in the ovariectomized murine model, as revealed by change in body and uterine weight, confirming the safety of EXD. These observations are in agreement with the rationality of the formula used in this paper.

  17. Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula.

    Science.gov (United States)

    Tam, Jacqueline Chor Wing; Ko, Chun Hay; Koon, Chi Man; Cheng, Zhang; Lok, Wong Hing; Lau, Ching Po; Leung, Ping Chung; Fung, Kwok Pui; Chan, Wai Yee; Lau, Clara Bik San

    2015-01-01

    Angiogenesis is vitally important in diabetic wound healing. We had previously demonstrated that a Chinese 2-herb formula (NF3) significantly stimulated angiogenesis of HUVEC in wound healing. However, the molecular mechanism has not yet been elucidated. In line with this, global expression profiling of NF3-treated HUVEC was performed so as to assess the regulatory role of NF3 involved in the underlying signaling pathways in wound healing angiogenesis. The microarray results illustrated that different panels of differentially expressed genes were strictly governed in NF3-treated HUVEC in a time-regulated manner. The microarray analysis followed by qRT-PCR and western blotting verification of NF3-treated HUVEC at 6 h revealed the involvement of various genes in diverse biological process, e.g., MAP3K14 in anti-inflammation; SLC5A8 in anti-tumorogenesis; DNAJB7 in protein translation; BIRC5, EPCAM, INSL4, MMP8 and NPR3 in cell proliferation; CXCR7, EPCAM, HAND1 and MMP8 in migration; CXCR7, EPCAM and MMP8 in tubular formation; and BIRC5, CXCR7, EPCAM, HAND1, MMP8 and UBD in angiogenesis. After 16 h incubation of NF3, other sets of genes were shown with differential expression in HUVEC, e.g., IL1RAPL2 and NR1H4 in anti-inflammation; miR28 in anti-tumorogenesis; GRIN1 and LCN1 in anti-oxidation; EPB41 in intracellular signal transduction; PRL and TFAP2A in cell proliferation; miR28, PRL and SCG2 in cell migration; PRL in tubular formation; and miR28, NR1H4 and PRL in angiogenesis. This study provided concrete scientific evidence in support of the regulatory role of NF3 on endothelial cells involved in wound healing angiogenesis.

  18. 用数学方法评估中草药对高龄蛋鸡生产性能的影响%Effects of Chinese Traditional Herbal Medicines on Production Performance of Aged Laying Hens

    Institute of Scientific and Technical Information of China (English)

    董玉龙; 李春红

    2012-01-01

    [目的]研究不同剂量中草药对高龄蛋鸡生产性能的影响.[方法]选用120只390日龄海兰褐蛋鸡,随机均分4组.分别用添加0.5%、1.0%、1.5%中草药的日粮饲喂①~③组鸡群,以饲喂未添加中草药日粮的鸡群为对照组(CK),连续给药15 d.观察各组每天的产蛋率、日产蛋量等生产性能指标.[结果]②组的产蛋率与CK差异极显著(P<0.01),提高了8.80%;③组的产蛋率与CK差异显著(P<0.05),提高了4.99%;②组和③组的日产蛋量与CK差异均极显著(P<0.01),分别提高了12.12%、6.82%;②组的料蛋比与CK差异极显著(P<0.01),降低了12.46%;③组的料蛋比与CK差异显著(P<0.05),降低了11.42%.其余指标无显著性差异(P>0.05).[结论]1.0%中草药添加剂量可以明显提高高龄蛋鸡的生产性能.%[Objective] To study the effects of different doses of Chinese traditional herbal medicines on the production performance of aged laying hens. [Method] 120 390-day-old HY-line variety brown hens were randomly divided into four groups, four treatment groups were designed, 0.5% , 1.0% and 1.5% herbal medicines were added in the daily diet of hens in group 1 -3 for 15 days in succession, the group without adding herbal medicine is CK. Then the laying rate and daily egg amount of hens in each treatment group were investigated. [ Result] The laying rate of group 2 improved by 8. 80% compared with the CK (P < 0. 01 ) ; the laying rate of group 3 improved by 4. 99% ( P < 0.05) ;the daily egg amount of group 2 and group 3 improved by 12. 12% and 6.82% respectively (P<0.01); the feed-egg ratio of group 2 reduced by 12.46% ( P < 0.01); while that of group 3 reduced by 11.42%. Other indexes showed no significant difference ( P < 0. 05 ). [Conclusion] The dose of 1.0% herbal medicine in diet could obviously improve the production performance of aged laying hens.

  19. 基于灰度共生矩阵的中药饮片横切面图像纹理特征参数的提取*%Extraction of Texture Feature Parameter of Transverse Section in Chinese Herbal Medicine by Gray-Level Co-occurrence Matrix

    Institute of Scientific and Technical Information of China (English)

    陶欧; 张燕玲; 陈茜; 王耘; 乔延江

    2014-01-01

    Digitalization is an important method for the objectification and quantification of quality control on Chi-nese herbal medicine. To solve the problem of texture online visualization of Chinese herbal medicine and the estab-lishment of automatic identification method based on the texture, 12 Chinese herbal medicines were selected to cap-ture the images of their transverse sections. A total of 11 features were extracted from images using Gray-level Co-occurrence Matrix (GLCM) method. Through analyzing the influence of distances and angles between pixels on identi-fication results, it was concluded that when the distance was d = 3 and the angle was Ɵ = 0o, the features extracted were suitable for expressing the texture of the transverse sections. The results indicated the feasibility of establishing the automatic identification method on Chinese herbal medicine based on image of transverse section. It will provide new technologies for the objectification and quantification of identification on Chinese herbal medicine.%中药数字化是中药质量控制客观化与定量化的重要手段之一。为了解决中药数字化过程中的数据质量问题和基于中药纹理图像的品种自动识别问题,本文选取12种中药饮片,采集其切面纹理图像,基于灰度共生矩阵提取了11个纹理特征参数,分析两像素间距、角度对纹理特征参数的影响,结果表明在像素间距d=3、角度兹=0毅时所提取的纹理特征参数有利于表征中药饮片切面纹理特征。通过对中药饮片切面图像纹理量化特征的提取和分析,表明了将图像分析方法用于中药品种自动识别的可行性,为中药直观鉴别的定量化、客观化提供了一套新的技术手段。

  20. Seven Chinese Herbal Medicines Affect Physiological and Biochemical Indices in Ictalurus punctatus%7种中草药对斑点叉尾鮰生理生化指标的影响

    Institute of Scientific and Technical Information of China (English)

    王庆奎; 陈成勋; 郭永军; 白东清; 乔之怡; 刘志伟; 丁莉莉; 邢克智

    2011-01-01

    [ Objective ] The aim was to provide theoretical basis for the reasonable application of seven kinds of Chinese herbal medicines in aquaculture industry. [ Method] Taking lctalurus purutatus as the study object, the impacts of seven Chinese herbal medicines (CHM),Belamcanda chinensis (L.) DC (BC),Eucommia ulmoides Oliver (EU),radix Dryopteris crassirhizoma (rDC) ,radix Paeoniae lactiflora (rPL), Glycyrrhiza uralensis Fiseh (GU) ,Polygonum cuspidutum Sieb et Zucc (PC),and Gardenia jasminoides Ellis (GJ) on the physiological and biochemical indices were tested. [ Result ] CHM could enhance the antioxidative capacity in serum and spleen while depress the antioxidative capacity in hepatopancreas. The superoxide dismutase (SOD) and catalase (CAT) activities in head kidney were enhanced significantly by BC. The SOD and CAT activities in muscle were enhanced significantly by EU ,rDC,PC and GJ. Serum lysozyme (LZM) activity was depressed significantly by rDC. The IZM activity in hepatopancreas and head kidney was enhanced significantly by BC. The PC depressed LZM activity in head kidney significantly.The LZM activity in gill was enhanced significantly by GU and GJ. The LZM activity in muscle was enhanced by rDC,EU and PC. The aspartate aminotransferase (AST) activity in hepatopancreas was depressed by rDC,GU and PC. The AST was enhanced by rPL significantly. The aianine aminotransferase (ALT) in hepatopancreas was depressed by rDC,EU ,GJ and GU. Leucocytes phagocytosis was enhanced significantly by BC,GU and GJ. [ Conclusion] Seven kinds of herbal medicines had different degrees of influences on the physiological and biochemical indices in Ictaluruspunctatus.%[目的]为7种中草药在水产养殖业中的合理使用提供理论依据.[方法]以斑点又尾鮰(Ictalurus punctatus)为研究时象,考察了射干、杜仲、贯众、白芍、甘草、虎杖和栀子7种中草药对生理生化指标的影响.[结果]中草药能提高血清和脾脏抗氧化能力,降低

  1. 五种外用中药制剂对兔螨病的疗效比较%Comparison of Curative Effects of Five Chinese Herbal Preparations for Rabbit Acariasis

    Institute of Scientific and Technical Information of China (English)

    谭德展; 肖秀娥; 刘毅

    2015-01-01

    T he treatment effectiveness of five Chinese Herbal preparation , Zanthoxylum preparation , Kushen decoction ,Chinaberry decoction ,Chajiesan and Mingxiongsan .to rabbit acariasis were observed and compared via direct contact with drugs to isolated adult mites in vitro or drugs used to mite affected part in rabbits ,in order to select the best one ,The results showed that acaricidal effect of pepper prepara‐tion was the best ,and the required time to cure was the shortest .%分别采用药物与离体螨虫成虫直接接触法和药物外用于螨病患部,比较了花椒制剂、苦参水煎剂、苦楝皮水煎剂、明雄散、擦疥散5种外用中药制剂的杀螨作用和对兔螨病的疗效。通过5种中药制剂杀螨作用和治疗效果观察,结果表明花椒制剂杀螨效果最好,治愈螨病所需时间最短。

  2. 沉香、乳香和没药中非法添加松香酸的研究与讨论%Study on the detection methods for sabietic acid illegally added in some Chinese herbal medicines

    Institute of Scientific and Technical Information of China (English)

    张亚双; 闵春艳

    2013-01-01

    目的 探讨沉香、乳香、没药等中药饮片中非法添加松香酸的检查方法.方法 主要采用性状鉴别、显微鉴别以及高效液相色谱鉴别方法,通过与对照品比对来确定是否非法添加松香酸.结果 实验中提供的样品中均检出松香酸.结论 以上方法操作简单,相结合使用能够方便、准确地检出沉香、乳香、没药饮片中添加的松香酸.%Objective To investigate the methods for detecting sabietic acid illegally added in some Chinese herbal medicines such as Aquilaria sinensis ( Lour. ) Gilg, Boszvellia carierii Birdw and Commiphora myrrha Engl. Methods We compared the samples with standard substances by using appearance identification, microscopy identification and HPLC methods. Results Sabietic acid were detected in all of the samples used in this experiment. Conclusion The method is simple,fast and sensitive.

  3. 基于PCA的中药黄芩药效评价方法研究%Research on principle component analysis based pharmacological effect evaluation method for a kind of Chinese herbal medicine, Baikal skullcap root

    Institute of Scientific and Technical Information of China (English)

    成巍; 侯恩广; 李珂; 李树彬; 赵渤年; 于宗渊

    2012-01-01

    We employ the algorithm of principal component analysis (PCA) to process the acquired chromatographic fingerprint and inhibitory rate by dimensionality reduction to realize chromatographic fingerprint and pharmacological effect correlation mode based comprehensive quality evaluation for Baikal skullcap root. Test results demonstrate its advances and higher reliability. This method provides us a new and referable idea for the quality evaluation of traditional Chinese herbal medicine.%为实现基于谱效相关模式的中药黄芩的质量综合评价,采用主成分分析法(principalcomponentanalysis,PCA)对采集到的色谱指纹图谱和药效指标(抑菌率)的大量数据进行降维处理,然后建立中药黄芩谱效结合评价系统,测试结果证明了该方法的先进性与可靠性。文中的降维方法可以为中药材质量评价研究提供一种新的、可借鉴的思路和方法。

  4. Research on the Extraction Technique of Three Kinds of Chinese Herbal Medicines of Ultraviolet Ray Absorber%3种中草药紫外吸收剂提取工艺的研究

    Institute of Scientific and Technical Information of China (English)

    岳鑫; 宋岱昔; 赵秀红

    2015-01-01

    对金银花、甘草和黄芩这3种中草药的紫外吸收剂提取工艺进行研究。利用紫外分光光度计确定3种中草药紫外吸收剂的最适波长;通过单因素试验分别考察料液比、微波时间、微波功率对3种中草药紫外吸收剂提取率的影响,并确定其最佳提取工艺参数。%This article used three kinds of Chinese herbal medicines - honeysuckle, licorice and skullcap to study the extraction technique. Using ultraviolet spectrophotometry to determine the most suitable wavelength for three kinds of UV absorber; it studied the influence of material liquid ratio, microwave time and microwave power on extraction rate of 3 kinds of UV absorber by using single factor experiment and determined the optimal extraction technique parameters.

  5. Chinese Herbal Medicines Might Improve the Long-Term Clinical Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: Results of a Decision-Analytic Markov Model

    Directory of Open Access Journals (Sweden)

    Shao-Li Wang

    2015-01-01

    Full Text Available Aims. The priority of Chinese herbal medicines (CHMs plus conventional treatment over conventional treatment alone for acute coronary syndrome (ACS after percutaneous coronary intervention (PCI was documented in the 5C trial (chictr.org number: ChiCTR-TRC-07000021. The study was designed to evaluate the 10-year effectiveness of CHMs plus conventional treatment versus conventional treatment alone with decision-analytic model for ACS after PCI. Methods and Results. We constructed a decision-analytic Markov model to compare additional CHMs for 6 months plus conventional treatment versus conventional treatment alone for ACS patients after PCI. Sources of data came from 5C trial and published reports. Outcomes were expressed in terms of quality-adjusted life years (QALYs. Sensitivity analyses were performed to test the robustness of the model. The model predicted that over the 10-year horizon the survival probability was 77.49% in patients with CHMs plus conventional treatment versus 77.29% in patients with conventional treatment alone. In combination with conventional treatment, 6-month CHMs might be associated with a gained 0.20% survival probability and 0.111 accumulated QALYs, respectively. Conclusions. The model suggested that treatment with CHMs, as an adjunctive therapy, in combination with conventional treatment for 6 months might improve the long-term clinical outcome in ACS patients after PCI.

  6. Combination of Chinese Herbal Medicines and Conventional Treatment versus Conventional Treatment Alone in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention (5C Trial: An Open-Label Randomized Controlled, Multicenter Study

    Directory of Open Access Journals (Sweden)

    Shao-Li Wang

    2013-01-01

    Full Text Available Aims. To evaluate the efficacy of Chinese herbal medicines (CHMs plus conventional treatment in patients with acute coronary syndrome (ACS after percutaneous coronary intervention (PCI. Methods and Results. Participants (n=808 with ACS who underwent PCI from thirteen hospitals of mainland China were randomized into two groups: CHMs plus conventional treatment group (treatment group or conventional treatment alone group (control group. All participants received conventional treatment, and participants in treatment group additionally received CHMs for six months. The primary endpoint was the composite of cardiac death, nonfatal recurrent MI, and ischemia-driven revascularization. Secondary endpoint was the composite of readmission for ACS, stroke, or congestive heart failure. The safety endpoint involved occurrence of major bleeding events. The incidence of primary endpoint was 2.7% in treatment group versus 6.2% in control group (HR, 0.43; 95% CI, 0.21 to 0.87; P=0.015. The incidence of secondary endpoint was 3.5% in treatment group versus 8.7% in control group (HR, 0.39; 95% CI, 0.21 to 0.72; P=0.002. No major bleeding events were observed in any participant. Conclusion. Treatment with CHMs plus conventional treatment further reduced the occurrence of cardiovascular events in patients with ACS after PCI without increasing risk of major bleeding.

  7. Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation

    Directory of Open Access Journals (Sweden)

    Chih-Jung Yao

    2016-01-01

    Full Text Available The Chinese herbal mixture, Tien-Hsien Liquid (THL, has been proven to suppress the growth and invasiveness of cancer cells and is currently regarded as a complementary medicine for the treatment of cancer. Our previous study using acute promyelocytic leukemia cells uncovered its effect on the downregulation of DNA methyltransferase 1 (DNMT1 which is often overexpressed in cancer cells resulting in the repression of tumor suppressors via hypermethylation. Herein, we explored the effects of THL in MCF-7 breast cancer cells that also demonstrate elevated DNMT1. The results show that THL dose-dependently downregulated DNMT1 accompanied by the induction of tumor suppressors such as p21 and p15. THL arrested cell cycle in G2/M phase and decreased the protein levels of cyclin A, cyclin B1, phospho-pRb, and AKT. DNMT1 inhibition was previously reported to exert a radiosensitizing effect in cancer cells through the repression of DNA repair. We found that THL enhanced radiation-induced clonogenic cell death in MCF-7 cells and decreased the level of DNA double-strand break repair protein, Rad51. Our observations may be the result of DNMT1 downregulation. Due to the fact that DNMT1 inhibition is now a mainstream strategy for anticancer therapy, further clinical trials of THL to confirm its clinical efficacy are warranted.

  8. Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation

    Science.gov (United States)

    Chow, Jyh-Ming; Yang, Chia-Ming; Kuo, Hui-Ching; Chang, Chia-Lun; Lee, Hsin-Lun; Lai, I-Chun; Chuang, Shuang-En

    2016-01-01

    The Chinese herbal mixture, Tien-Hsien Liquid (THL), has been proven to suppress the growth and invasiveness of cancer cells and is currently regarded as a complementary medicine for the treatment of cancer. Our previous study using acute promyelocytic leukemia cells uncovered its effect on the downregulation of DNA methyltransferase 1 (DNMT1) which is often overexpressed in cancer cells resulting in the repression of tumor suppressors via hypermethylation. Herein, we explored the effects of THL in MCF-7 breast cancer cells that also demonstrate elevated DNMT1. The results show that THL dose-dependently downregulated DNMT1 accompanied by the induction of tumor suppressors such as p21 and p15. THL arrested cell cycle in G2/M phase and decreased the protein levels of cyclin A, cyclin B1, phospho-pRb, and AKT. DNMT1 inhibition was previously reported to exert a radiosensitizing effect in cancer cells through the repression of DNA repair. We found that THL enhanced radiation-induced clonogenic cell death in MCF-7 cells and decreased the level of DNA double-strand break repair protein, Rad51. Our observations may be the result of DNMT1 downregulation. Due to the fact that DNMT1 inhibition is now a mainstream strategy for anticancer therapy, further clinical trials of THL to confirm its clinical efficacy are warranted. PMID:27525019

  9. The Research of Total Chemical Composition (Extractum) Extracting Technology for Chinese Herbal Compound%中药复方总化学成分(浸膏)提取工艺研究

    Institute of Scientific and Technical Information of China (English)

    江平康; 刘群; 杨松沛; 卢亚艺; 唐帝; 朱子凤; 周李

    2011-01-01

    The aim of this paper is to improve the clinical curative effect of Chinese herbal compouncKBai hua she she cao, Honeysuckle, Astragalus,Licorice) and promote research of antiviral mechanism of action and provide the scientific basis for Chinese herbal compound formulations reform and industrialized production. This study adopted orthogonal design with single factor investigation to optimize compound water extraction and alcohol precipitation technology which were follows: the weight of water extracting was referred as index for checking and choosing L9(34) orthogonal table design test to optimize the time of soaking, water consumption, decoction time, decocting number. The HPLC was used to measure content of glycyrrhizic acid of of Chinese compound condensate which was referred as index for optimizing. The L9 (34) orthogonal table was selected to optimize ethanol concentration, ethanol dosage and the time of alcohol precipitation. The best technology of water extraction was soaking for 1 hour,adding 12 times alcohol into Chinese medical materials, decocting 4 times and 1. 5 hour each. The best technology of the alcohol precipitation was to adding 4 times 80% alcohol into extractum and then sedimenting 16 hours. With the practical production and cost factors, the technology of water extracting and alcohol sedimentating of chinese herbal compound water extracting and alcohol sedimentating was made by the way of soaking one hour,adding 12 times alcohol into chinese medical materials, decocting 3 times and 1 hour each time,adding 3 times 65% alcohol into extractum and then alcohol sedimenting 16 hours. The yield of water extraction extractum was 57. 2% and the content of glycyrrhizic acid of extractum was 0. 42% which all close to the maximum result in the results of orthogonal design.%本研究旨在提高白花蛇舌草、金银花、黄芪、甘草组成的中药复方的临床疗效和抗病毒作用机理研究,为复方剂型改革和工业化生产提供科学

  10. Hedyotis diffusa Combined with Scutellaria barbata Are the Core Treatment of Chinese Herbal Medicine Used for Breast Cancer Patients: A Population-Based Study

    OpenAIRE

    Yuan-Chieh Yeh; Hsing-Yu Chen; Sien-Hung Yang; Yi-Hsien Lin; Jen-Hwey Chiu; Yi-Hsuan Lin; Jiun-Liang Chen

    2014-01-01

    Traditional Chinese medicine (TCM), which is the most common type of complementary and alternative medicine (CAM) used in Taiwan, is increasingly used to treat patients with breast cancer. However, large-scale studies on the patterns of TCM prescriptions for breast cancer are still lacking. The aim of this study was to determine the core treatment of TCM prescriptions used for breast cancer recorded in the Taiwan National Health Insurance Research Database. TCM visits made for breast cancer i...

  11. Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways

    Science.gov (United States)

    Li, Xue-mei; Peng, Jing-hua; Sun, Zhao-lin; Tian, Hua-jie; Duan, Xiao-hua; Liu, Lin; Ma, Xin; Feng, Qin; Liu, Ping; Hu, Yi-yang

    2016-01-01

    Aim: Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis. In this study we attempted to confirm the therapeutic effects of CGA formula in dimethylnitrosamine (DMN)-induced liver fibrosis in rats, and to identify the mechanisms of anti-fibrotic actions. Methods: Rats were injected with DMN (10 mg·kg−1·d−1, ip) for 3 consecutive days per week over a 4-week period. The rats then were orally administered with CGA formula (CS-PS 60 mg·kg−1·d−1, gypenosides 50 mg·kg−1·d−1 and amygdalin 80 mg·kg−1·d−1) daily in the next 2 weeks. CS-PS, gypenosides or amygdalin alone were administered as individual component controls, whereas colchicine and FZHY were used as positive controls. Serum biomarkers were measured. Hepatic injury, collagen deposition and stellate cell activation were examined. The MMP activities, expression of TIMP protein and proteins involved in the TGF-β1/Smad signaling pathways in liver tissues were assayed. Results: In DMN-treated rats, administration of CGA formula significantly decreased serum ALT, AST and total bilirubin and hepatic hydroxyproline levels, increased serum albumin level, and attenuated liver fibrosis as shown by histological examination. Furthermore, these effects were comparable to those caused by administration of FZHY, and superior to those caused by administration of colchicine or the individual components of CGA formula. Moreover, administration of CGA formula significantly decreased the protein levels of α-SMA, TGF-β1, TGF-β1 receptor (TβR-I), p-TβR-I, p-TβR-II, p-Smad2, p-Smad3, TIMP1 and TIMP2, as well as MMP2 and MMP9 activities in liver tissues of DMN-treated rats. Conclusion: Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats, and this effect was likely associated with the down-regulation of MMP2/9 activities, TIMP1/2 protein

  12. 自制中药协定方外敷会阴预防会阴感染的临床疗效观察%Effects of Chinese Herbal Prescription for Prevention of Perineal Trauma Perineum Infection

    Institute of Scientific and Technical Information of China (English)

    王玉妃; 王仁灿

    2012-01-01

    [目的]观察自制中药协定方外敷会阴,预防产后会阴感染的临床疗效.[方法]1 580例会阴缝合过的产妇随机分为治疗组950例和对照组630例,治疗组每天用0.5%PVP-1消毒会阴早晚各一次后,再加用自制协定方外敷会阴,1次/d,对照组仅用0.5%PVP-1消毒会阴,2次/do5-7天为1个疗程,疗效结束后进行疗效判定并记录,观察会阴疼痛及不适感的程度,会阴水肿情况,有无感染等,特别注意观察有无皮肤过敏反应.[结果]治疗组会阴舒适度明显高于对照组,会阴水肿、伤口感染率明显低于对照组(P<0.05).[结论]自制中药协定方会阴局部湿热敷可减少术口感染,提高会阴舒适度.%[Objective] Observation of external application of herbal prescription on perineal, prevention of postpartum perineal infection. [Method] 1580 cases of perineal suture pregnant women were randomly divided into the treatment group 950 cases and control group 630 cases, the treatment group with 0.5% PVP-Ⅰ disinfecting perineum every day, Rixi of all time, coupled with the self-made prescription topical perineum, 1 time/day, the control group only with 0.5%PVP-Ⅰ disinfect perineum,2 times/day. 5~7 days for a course of treatment, observe curative effect and record perineal pain and discomfort degree, per-ineal edema, without infection, with particular attention to observing whether there is an allergic skin reaction. [Result] Perineal comfort in treatment group was significantly higher than control group, perineal edema and wound infection rate was significantly lower than that of control group(P<0.05).[Conclusion] Effects of Chinese herbal prescription in perineum local hot wet compress reduces postoperative mouth infection and improves the comfort of the perineum.

  13. Evaluation on the efficacy and safety of Chinese herbal medication Xifeng Dingchan Pill in treating Parkinson's disease: study protocol of a multicenter,open-label, randomized active-controlled trial

    Institute of Scientific and Technical Information of China (English)

    Jie Zhang; Yun-zhi Ma; Xiao-ming Shen

    2013-01-01

    BACKGROUND:Parkinson's disease (PD) is a complicated disease,commonly diagnosed among the elderly,which leads to degeneration of the central nervous system.It presently lacks an effective therapy for its complex pathogenesis.Adverse effects from Western drug-based medical intervention prevent long-term adherence to these therapies in many patients.Traditional Chinese medicine (TCM) has long been used to improve the treatment of PD by alleviating the toxic and adverse effects of Western drug-based intervention.Therefore,the aim of this study is to evaluate the efficacy and safety of Xifeng Dingchan Pill (XFDCP),a compound traditional Chinese herbal medicine,taken in conjunction with Western medicine in the treatment of PD patients at different stages in the progression of the disease.METHODS AND DESIGN:This is a multicenter,randomized controlled trial.In total,320 patients with early-(n =160) and middle-stage PD (n =160) will be enrolled and divided evenly into control and trial groups.Of the 160 patients with early-stage PD,the trial group (n =80) will be given XFDCP,and the control group (n =80) will be given Madopar.Of the 160 patients with middle-stage PD,the trial group (n =80) will be given XFDCP combined with Madopar and Piribedil,and the control group (n =80) will be given Madopar and Piribedil.The Unified Parkinson's Disease Rating Scale scores,TCM symptoms scores,quality of life,change of Madopar's dosage and the toxic and adverse effects of Madopar will be observed during a 3-month treatment period and through a further 6-month follow-up period.DISCUSSION:It is hypothesized that XFDCP,combined with Madopar and Piribedil,will have beneficial effects on patients with PD.The results of this study will provide evidence for developing a comprehensive therapy regimen,which can delay the progress of the disease and improve the quality of life for PD patients in different stages.TRIAL REGISTRATION:This trial has been registered in the Chinese Clinical Trial

  14. Análise farmacognóstica e atividade antibacteriana de extratos vegetais empregados em formulação para a higiene bucal Herbal extracts in an experimental mouthwash: pharmacognostics analysis and antibacterial activity

    Directory of Open Access Journals (Sweden)

    Cynthia Helena Gontijo Cordeiro

    2006-09-01

    Full Text Available A utilização de extratos vegetais vem se tornando uma alternativa importante para a prevenção de doenças periodontais. Este trabalho objetivou desenvolver uma formulação de enxagüatório bucal, contendo, em associação, extratos hidroalcoólicos de Rosmarinus officinalis, Plantago major, Tabebuia impetiginosa, Achillea millefollium e Nasturtium officinale; avaliar sua composição farmacognóstica e sua atividade antibacteriana, como também da fórmula proposta. Foram realizados estudos de pré-formulação e análises farmacognósticas para as espécies vegetais. A atividade antibacteriana in vitro foi observada por meio dos métodos de difusão em disco de papel, por hole- plate e por template, frente a Staphylococcus aureus, Bacillus subtilis, Escherichia colik, Enterococcus faecalis e Pseudomonas aeruginosa. A concentração inibitória mínima (CIM foi determinada por meio do método de macrodiluições sucessivas em caldo. Os resultados obtidos apresentaram-se de acordo com o histórico farmacognóstico das drogas estudadas. Todas as bactérias foram inibidas pelos extratos, observando-se que as espécies S. aureus e B. subtilis mostraram, aparentemente, maior sensibilidade. A CIM variou, em relação a sensibilidade de cada espécie bacteriana estudada, de 312,5 µL/mL a 1250 µL/mL para os extratos vegetais e de 625 µL/mL a 2500 µL/mL para o enxaguatório bucal. São necessários estudos complementares para a confirmação da eficácia deste produto e sua utilização na prevenção de doenças periodontais.In this study, herbs and hidroalcoholic extracts of Nasturtium officinale, Rosmarinus officinalis, Tabebuia impetiginosa, Plantago major and Achillea millefollium, were investigated for pharmacognostics analysis (flavonoids, alkaloids, tanins, saponins and antraquinones and antibacterial activity (against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Enterococcus faecalis e Pseudomonas aeruginosa. In vitro

  15. Makeham's Formula

    DEFF Research Database (Denmark)

    Astrup Jensen, Bjarne

    analysis. We use Makeham's formula to decompose the return on a bond investment into interest payments, realized capital gains and accrued capital gains for a variety of accounting rules for measuring accruals in order to study the theoretical properties of these accounting rules, their taxation...

  16. Determination of organophosphorus pesticide residues in main Chinese herbal medicines in Qinghai Plateau%青海高原主要中药材中有机磷类农药残留的测定

    Institute of Scientific and Technical Information of China (English)

    韩澄华; 崔鹏

    2012-01-01

    Objective To establish a capillary gas chromatography method to determinate the 10 kinds of organophosphorus pesticide residues in Chinese herbal medicines in Qinghai plateau. Method The samples were extracted by acetonitrile ultrasonic, dehydrated by anhydrous sodium sulfate, purified by graphitized carbon ( CARB) / amino (NH2) solid - phase extraction column after concentration, determined constant volum by acetone, separated by DB - 7 capillary column, and determined the nature and quantification by FPD detector. Results These 10 kinds of organophosphorus pesticides presented better linear relation in a concentration range of 0. 10 ~ 1.0g/ml. The lowest detection limit of this method was between 0. 0058 mg/kg and 0. 060 mg/kg. The additive amount of mixed standard solution of these 10 organophosphorus was 0. 5mg/kg. It had measured parallelly for 6 times. The average recovery rate was between 67. 1% and 120. 0% , and the relative standard deviation was between 2. 9% and 5. 7%. Conclusion This method had high sensitivity, accuracy and repeatability, which was suitable for the measurement of 10 kinds of organophosphorus pesticides residues in Chinese herbal medicine in basic units.%目的 建立毛细管气相色谱法测定青海高原中药材中10种有机磷农药残留的分析方法.方法 样品经乙腈超声提取,无水硫酸钠脱水,浓缩后经石墨化碳( CARB)/氨基(NH2)串联固相萃取柱提纯净化,丙酮定容,采用DB -7毛细管柱分离,FPD检测器定性定量.结果 10种有机磷农药在0.10~1.0μg/mL的浓度范围内呈较好的线性关系,该方法的最低检出限为0.0 058~0.060mg/kg.10种有机磷混合标准溶液添加量为0.5mg/kg,平行测定6次,平均回收率为67.1%~ 120.0%,相对标准偏差为2.9%~5.7%.结论 该方法具有较高灵敏度、准确、重现性好等优点,适于中药材中10种有机磷类农药残留在基层单位的测定.

  17. 中药药源性砷中毒的护理分析%Nursing Analysis of Chinese Herbal Medicine Source of Arsenic Poisoning

    Institute of Scientific and Technical Information of China (English)

    陈丽丽

    2015-01-01

    目的:探讨中药源性砷中毒的临床护理体验及其效果。方法选择36例患者分为观察组与对照组,对观察组实施全面护理,对照组实施一般护理,统计两组患者的治疗前、后的尿砷结果。结果对照组尿砷结果显著优于对照组(<0.05)。结论对中药源性砷中毒患者实施积极有效的心理护理、饮食保健以及给药护理等全面护理措施,是降低尿砷结果,促进患者康复的有效方法。%Objective Discuss the clinical ef ect of nursing to traditional Chinese medicine-induced arsenic poisoning .Methods Thirty-six cases of patients were randomly selected and divided into experimental group and control group, the experimental group were implemented comprehensive care with this study, the control group were only used general nursing, then compare the value of urine arsenic of two groups in pretherapy and post-treatment. Results The value of urine arsenic of experimental group were bet er than that of the control group ( <0.05).Conclusion The ef ective comprehensive care to patients traditional Chinese medicine-induced arsenic poisoning such as psychological nursing , diet care and drug treatments could be the ef ective method to reduce the value of urine arsenic and promote patients recover.

  18. Screening and performance test of efficient broad - spectrum composite sunscreen agent from traditional Chinese herbal medicines%中草药高效广谱复合防晒组分的筛选和性能测试

    Institute of Scientific and Technical Information of China (English)

    俞晨秀; 潘武

    2011-01-01

    通过对201种中草药在防晒光区(290~400 nm)紫外吸收能力的研究,选取紫外吸收强、吸收波段互补、调配着色浅的苦丁茶和槐米两种生药萃取液复配制得复合防晒剂.结果表明:复合防晒剂在水剂中的用量≤0.3 g/L,乳剂中的用量≤0.7 g/L时的使用色度合适,累积日照20h下稳定,50℃下热稳定,pH =4~7之间稳定,室内存放1 a稳定,具有广谱、高效的防晒效果.%Through UV (with spectrum of 290 ~400 nm) absorption capacity study of 201 kinds of traditional Chinese herbal medicine, Ilex kudingcha extract and Sophora japonica extract were selected to formulate a composite sunscreen agent based upon their strong UV absorption capacity, complementary absorption bands and light coloration. Experiment results showed that the composite sunscreen agent has the appropriate color when the mass concentration is below 0. 3 g/L in aqueous formulation and below 0. 7 g/L in emulsion formulation. The sunscreen agent is stable under cumulative sunshine of 20 h, temperature of 50 t ,and pH of 4 ~ 7. Under ambient condition, it can be stable for one year.

  19. 5种中草药乙醇提取物对猪油的抗氧化作用%Antioxidation of ethanol extracts from five Chinese herbal medicine to the lard

    Institute of Scientific and Technical Information of China (English)

    徐金瑞; 孙育斌; 卢晓玲

    2011-01-01

    POV was used as an index, and the antioxidative activities of five ethanol extracts from Chinese herbal medicine including Licorice, Epimedium, Astragalus, Huangcen and Forsythia to the lard were compared by Schaal oven - storage test.The results showed that the antioxidative activities of five extracts were different, and their sequences were: Licorice > Astragalus > Huangcen > Epimedium > Forsythia.However, five ethanol extracts could prevent the oxidative reaction of lard, and the positive correlation existed between antioxidant capacity and extracts contents within the concentration of 0.1% -0.3%.%采用Schaal烘箱法,以过氧化值(POV)为评价指标,比较了甘草、淫羊藿、黄芪、黄苓、连翘5种中草药乙醉提取物时猪油的抗氧化作用效果.结果表明,5种中草药乙醉提取物抗氧化活性存在一定差异,表现为甘草>黄芪>黄苓>淫羊藿>连翘.总体上5种中草药乙醉提取物均可有效延缓猪油的氧化反应,且5种提取物在0.1%-0.3%添加量范围内其抗氧化能力随添加量的增加而增强,呈现一定的量效关系.

  20. Chinese herbal medicine YADRAN tooth powder dentifrice in orthodontic treatment efficacy of periodontal maintenance%中草药牙得安牙粉在正畸治疗中对牙周维护的疗效观察

    Institute of Scientific and Technical Information of China (English)

    黄健清

    2011-01-01

    Objective: Discussion on YADRAN tooth powder dentifrice in orthodontic treatment of periodontal clinical effects. Methods: Choose the Complexing deformity in patients with 50 cases,randomly divided into two groups. Experimental group: basic treatment, oral hygiene education and YADRAN tooth powder. Control group: basic treatment, oral hygiene education and regular toothpaste. Before treatment, treatment for three months, six months of their clinical treatment of periodontal index detection. Results:The clinical treatment of periodontal parameters between two groups was not significant, P > 0.05. Treatment for three months, six months, the clinical periodontal parameters between the two groups was significant, P < 0.05. Conclusion:Chinese herbal medicine YADRAN tooth powder can reduce plaque formation, improve gum health.%目的:探讨中草药牙得安牙粉在正畸治疗中对牙周维护的临床效果.方法:选择50例错合畸形患者,随机分成两组,实验组:基础治疗、口腔卫生宣教加中草药牙得安草粉.对照组:基础治疗、口腔卫生宣教加普通牙膏.分别在矫治前、矫治三个月,矫治六个月时对其进行临床牙周指标检测.结果:矫治前两组临床牙周指标差异无显著性,P>0.05.矫治三个月、六个月时,两组临床牙周指标差异均有显著性,P<0.05.结论:中草药牙得安牙粉能减少牙菌斑形成,有效改善牙龈健康.

  1. Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction.

    Science.gov (United States)

    Zheng, Ken Y Z; Zhang, Zhen X; Du, Crystal Y Q; Zhang, Wendy L; Bi, Cathy W C; Choi, Roy C Y; Dong, Tina T X; Tsim, Karl W K

    2014-02-01

    Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, ha