WorldWideScience

Sample records for child vaccination status

  1. Effects of the introduction of new vaccines in Guinea-Bissau on vaccine coverage, vaccine timeliness, and child survival

    DEFF Research Database (Denmark)

    Fisker, Ane B; Hornshøj, Linda; Rodrigues, Amabelia;

    2014-01-01

    BACKGROUND: In 2008, the GAVI Alliance funded the introduction of new vaccines (including pentavalent diphtheria-tetanus-pertussis [DTP] plus hepatitis B and Haemophilus influenzae type b antigens) in Guinea-Bissau. The introduction was accompanied by increased vaccination outreach services...... and a more restrictive wastage policy, including only vaccinating children younger than 12 months. We assessed coverage of all vaccines in the Expanded Program on Immunizations before and after the new vaccines' introduction, and the implications on child survival. METHODS: This observational cohort study...... used data from the Bandim Health Project, which has monitored vaccination status and mortality in randomly selected village clusters in Guinea-Bissau since 1990. We assessed the change in vaccination coverage using cohort data from children born in 2007 and 2009; analysed the proportion of children who...

  2. Does the effect of vitamin A supplements depend on vaccination status?

    DEFF Research Database (Denmark)

    Fisker, Ane B; Aaby, Peter; Bale, Carlito;

    2012-01-01

    who had diphtheria-tetanus-pertussis vaccine as their last vaccine (3680 children, adjusted MRR=1.29 (0.52; 3.22), p=0.04 for interaction). Conclusion The effect of VAS differed by most recent vaccination, being beneficial after measles vaccine but not after diphtheria-tetanus-pertussis vaccine.......Objective Vitamin A supplementation (VAS) is estimated to reduce all-cause mortality by 24%. Previous studies indicate that the effect of VAS may vary with vaccination status. The authors evaluated the effect of VAS provided in campaigns on child survival overall and by sex and vaccination status...... 2008 for children between 6 and 35 months of age. Vaccination status was ascertained by inspection of vaccination cards. All children were followed prospectively. Outcome measures Mortality rates for supplemented and non-supplemented children were compared in Cox models providing mortality rate ratios...

  3. A Doctor's Words Key to Whether Child Gets HPV Vaccine

    Science.gov (United States)

    ... A Doctor's Words Key to Whether Child Gets HPV Vaccine Parents most receptive to messages about the shot's ... language doctors use when recommending the human papillomavirus (HPV) vaccine can influence whether parents will have their children ...

  4. Current status of rotavirus vaccines

    Institute of Scientific and Technical Information of China (English)

    Ching-Min Wang; Shou-Chien Chen; Kow-Tong Chen

    2015-01-01

    Background: Rotaviruses remain the major cause of childhood diarrheal disease worldwide and of diarrheal deaths of infants and children in developing countries. The huge burden of childhood rotavirus-related diarrhea in the world continues to drive the remarkable pace of vaccine development. Data sources: Research articles were searched using terms "rotavirus" and "rotavirus vaccine" in MEDLINE and PubMed. Articles not published in the English language, articles without abstracts, and opinion articles were excluded from the review. After preliminary screening, all articles were reviewed and synthesized to provide an overview of current vaccines and vaccination programs. Results: In this review of the global rotavirus vaccines and vaccination programs, the principles of rotavirus vaccine development and the efficacy of the currently licensed vaccines from both developed and developing countries were summarized. Conclusions: Rotavirus is a common cause of diarrhea in children in both developed and developing countries. Rotavirus vaccination is a cost-effective measure to prevent rotavirus diarrhea.

  5. Your Child's Immunizations: Diphtheria, Tetanus & Pertussis Vaccine (DTaP)

    Science.gov (United States)

    ... Palsy: Shannon's Story" 5 Things to Know About Zika & Pregnancy Your Child's Immunizations: Diphtheria, Tetanus & Pertussis Vaccine (DTaP) KidsHealth > For Parents > Your Child's Immunizations: Diphtheria, ...

  6. Current status of toxoplasmosis vaccine development.

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    Kur, Józef; Holec-Gasior, Lucyna; Hiszczyńska-Sawicka, Elzbieta

    2009-06-01

    Toxoplasmosis, caused by an intracellular protozoan parasite, Toxoplasma gondii, is widespread throughout the world. The disease is of major medical and veterinary importance, being a cause of congenital disease and abortion in humans and domestic animals. In addition, recently it has gained importance owing to toxoplasma encephalitis in AIDS patients. In the last few years, there has been considerable progress towards the development of a vaccine for toxoplasmosis, and a vaccine based on the live-attenuated S48 strain was developed for veterinary uses. However, this vaccine is expensive, causes side effects and has a short shelf life. Furthermore, this vaccine may revert to a pathogenic strain and, therefore, is not suitable for human use. Various experimental studies have shown that it may be possible to develop a vaccine against human toxoplasmosis. Recent progress in knowledge of the protective immune response generated by T. gondii and the current status of development of a vaccine for toxoplasmosis are highlighted.

  7. Hepatitis virus vaccines: present status.

    OpenAIRE

    Krugman, S.

    1982-01-01

    During the past decade there has been extraordinary progress toward the development of vaccines for the prevention of type A and type B hepatitis. The successful propagation of hepatitis A virus in cell culture in 1979 was followed by the preparation of experimental live attenuated hepatitis A vaccines that have been shown to induce antibody in marmosets and chimpanzees and protect immunized marmosets against challenge with hepatitis A virus. The first human immunization trials will begin in ...

  8. Child and adolescent psychiatry and family status

    DEFF Research Database (Denmark)

    Esbjørn, Barbara Hoff; Levin, Eline; Høyer, Mette;

    2008-01-01

    BACKGROUND: Much attention has been given to parental separation as a possible risk factor for adverse child development; however, little information is available regarding the family status of children referred to psychiatric facilities. AIMS: To assess the association between psychiatric illness...... children are at increased risk of not living with both biological parents independent of age of the child....

  9. Paternal education status significantly influences infants’ measles vaccination uptake, independent of maternal education status

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    Rammohan Anu

    2012-07-01

    Full Text Available Abstract Background Despite increased funding of measles vaccination programs by national governments and international aid agencies, structural factors encumber attainment of childhood measles immunisation to levels which may guarantee herd immunity. One of such factors is parental education status. Research on the links between parental education and vaccination has typically focused on the influence of maternal education status. This study aims to demonstrate the independent influence of paternal education status on measles immunisation. Methods Comparable nationally representative survey data were obtained from six countries with the highest numbers of children missing the measles vaccine in 2008. Logistic regression analysis was applied to examine the influence of paternal education on uptake of the first dose of measles vaccination, independent of maternal education, whilst controlling for confounding factors such as respondent’s age, urban/rural residence, province/state of residence, religion, wealth and occupation. Results The results of the analysis show that even if a mother is illiterate, having a father with an education of Secondary (high school schooling and above is statistically significant and positively correlated with the likelihood of a child being vaccinated for measles, in the six countries analysed. Paternal education of secondary or higher level was significantly and independently correlated with measles immunisation uptake after controlling for all potential confounders. Conclusions The influence of paternal education status on measles immunisation uptake was investigated and found to be statistically significant in six nations with the biggest gaps in measles immunisation coverage in 2008. This study underscores the imperative of utilising both maternal and paternal education as screening variables to identify children at risk of missing measles vaccination prospectively.

  10. Edible vaccines: Current status and future

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    Lal P

    2007-01-01

    Full Text Available Edible vaccines hold great promise as a cost-effective, easy-to-administer, easy-to-store, fail-safe and socioculturally readily acceptable vaccine delivery system, especially for the poor developing countries. It involves introduction of selected desired genes into plants and then inducing these altered plants to manufacture the encoded proteins. Introduced as a concept about a decade ago, it has become a reality today. A variety of delivery systems have been developed. Initially thought to be useful only for preventing infectious diseases, it has also found application in prevention of autoimmune diseases, birth control, cancer therapy, etc. Edible vaccines are currently being developed for a number of human and animal diseases. There is growing acceptance of transgenic crops in both industrial and developing countries. Resistance to genetically modified foods may affect the future of edible vaccines. They have passed the major hurdles in the path of an emerging vaccine technology. Various technical obstacles, regulatory and non-scientific challenges, though all seem surmountable, need to be overcome. This review attempts to discuss the current status and future of this new preventive modality.

  11. [Present status of vaccines in 1989].

    Science.gov (United States)

    Roussey, M; Dabadie, A

    1989-01-01

    The authors describe 2 new vaccines now available in France: one is the GenHevac, an hepatitis B vaccine, the first virus recombinant vaccine; the other one is the Typhim Vi, a polysaccharide typhoid vaccine. Three other vaccines are currently used in foreign countries and will be soon available: the Hemophilus influenzae vaccine, the acellular pertussis vaccine and the varicella vaccine. Rotavirus and Cytomegalovirus vaccines are studied for their clinical efficacy.

  12. Status of tribal girl child.

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    Dashora, R

    1995-01-01

    This article describes socioeconomic conditions for the girl child among tribals in India. India has the largest tribal population in the world: about 67.7 million in 1991. 1 in every 12 Indian women is a tribal woman. Tribal populations are distributed unevenly across India. 85% of the tribal population live in the central belt extending from Gujarat and Rajasthan to Maharashtra, Madhya Pradesh, Andhra Pradesh, Orissa, and Bihar states to the east. There are 250 officially recognized tribal groups. Article 46 of the Constitution provides for special care in education and economic matters for scheduled tribes (STs) and for protection from social injustice and exploitation. In practice, STs are denied rights over resources, and their social governing systems are not recognized. Tribal girls do not have the same inheritance rights, except in matrilineal society. The incidence of child labor is very high. Girls are paid less than boys and are forced to stay home from school to care for younger siblings. Tribal girls are denied nutritious food and proper health care. Literacy among tribal women increased from 3.16% in 1961 to 18.19% in 1991. Male literacy increased from 13.04% to 32.5%. Girl children are enrolled in school but are withdrawn early. Lower female enrollment is attributed to lack of parental awareness, lack of institutional support, girls who are the eldest in the family, irrelevant school curricula, and teaching in a language different from the child's spoken language. During 1991-92, there were insufficient numbers of schools for girls. Tribal mothers have high rates of anemia, and girl children receive less than the desired nutritional level. Tribal girls suffer from inadequate food intake, hard work, and diseases. The community is also deficient in adequate food intake. Tribals have learned to live with minimum subsistence. Tribals need to be made aware of politics, economic opportunities, and how to achieve a higher quality of life. PMID:12158010

  13. Analysis of vaccination status and its influencing factors of tetanus toxoid vaccine of child-bearing age women in Hainan high-risk areas.%海南省育龄妇女破伤风疫苗接种影响因素调查

    Institute of Scientific and Technical Information of China (English)

    朱坚; 符振旺; 王春雷

    2011-01-01

    目的 了解影响海南省育龄妇女破伤风类毒素疫苗(TT)接种因素,为制定消除新生儿破伤风方案提供科学依据.方法 选取海南省新生儿破伤风发病较高的4个市县8个乡镇作抽取40个行政村作为问卷调查点.每个调查点随机抽取10名18 ~49岁育龄妇女进行问卷调查.结果 共完成399名育龄妇女问卷调查,大部分群众和育龄妇女对新生儿破伤发病原因和防治相关知识缺乏了解;孕产妇在家分娩率为62.4%,选择在家分娩的主要原因是住院分娩费用太高、交通不便、封建迷信与落后的风俗习惯影响;育龄妇女接种TT主动意识不高,TT接种率为57.79%.,未接种的原因主要有外出打工、怕影响生育、怕影响劳动和收费.群众易于接受宣传形式依次是电视、口头宣传、宣传画和广播.结论 海南省新生儿破伤风高危地区群众和育龄妇女对新生儿破伤发病原因和防治相关知识缺乏了解,育龄妇女TT接种率较低,应加强消毒接生与TT接种的宣传工作.%Objective To know the vaccination status and its influencing factors of tetanus toxoid vaccine of child-bearing age women in neonatal tetanus high-risk areas in Hainan to provide scientific basis for eliminating neonatal tetanus in Hainan province. Methods To choose four villages and towns of two city and county which incidence of neonatal tetanus was highest as investigation sites. Project interview and questionnaire survey in families were taken to investigate information. Results The interview of 218 persons of 24 groups and questionnaire survey of 199 child-bearing age women were completed. Most of the women didn't know the reason and prevention of neonatal tetanus. 62.4% of puerperant gave birth to children at home. The main reasons were high cost in hospital,traffic inconvenience,feudal superstition and backward customs. The active consciousness of child-bearing age women for inoculating tetanus toxoid was not

  14. Knowledge of Hepatitis B Vaccine among Operating Room Personnel in Nigeria and Their Vaccination Status

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    Emeka B. Kesieme

    2011-01-01

    Full Text Available Background. Hepatitis B virus (HBV infection is a well recognised occupational health hazard preventable by vaccination. Objectives. To determine the knowledge of operating room personnel (ORP in Nigeria about the Hepatitis B vaccine, their perception of Hepatitis B vaccination and vaccination status against HBV. Methods. Four university hospitals were selected by simple random sampling. A structured questionnaire was administered to 228 ORP after obtaining consent. Result. Only 26.8% of ORP were vaccinated against HBV. The primary reason for not being vaccinated or for defaulting from vaccination was lack of time. Differences in age, sex, duration of practice and respondent's institution between vaccinated and unvaccinated ORP were not significant (P>0.05. The majority (86.8% had the awareness of the existence of Hepatitis B vaccine. 83.8% of respondents believed that the vaccine should be given to the ORP as part of work place safety measures. The majority were aware of the modes of transmission of HBV infection. 78.9% of respondents believed that Hepatitis B vaccine is safe and 81.1% would recommend it to another staff. Conclusion. Despite a good knowledge about HBV infection and vaccine, most of ORP are still not vaccinated. Hepatitis B vaccination should be a prerequisite for working in the theatre, hence putting surgical patients at reduced risk.

  15. The provision of pharmaceutical advice improves patient vaccination status

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    Fuchs J

    2006-12-01

    Full Text Available Aim: To increase vaccination rates in the wealthy industrial nation of Germany. For a variety of reasons there is a substantial deficit in the number of individuals who receive vaccinations in comparison with other industrialized countries.Methods: In Autumn 2003, a regional vaccination consultation was initiated over a five-week period. Individuals involved in the study provided general information, including their age, health status, and vaccination records, and received an extensive consultation in a pharmacy in Jena, Germany. Participants were provided with a written overview of their vaccination status. After approximately five weeks, the vaccination status of each individual was recorded.Results: 312 of 2500 patients received intensive vaccination education based on their accompanying vaccination documentation. Older individuals, who are known for having the largest vaccination gap in Germany, represented the highest percentage of people who used this service. The five most commonly required vaccinations had increased significantly, five weeks after the consultation. These vaccination rate increases included diphtheria, which rose from 55.8 to 71.2%, tetanus, which rose from 73.1 to 86.5%, influenza, which rose from 46.5 to 74.7%, pneumococcal, which rose from 32.4 to 62.8%, and tick-borne encephalitis, which rose from 31.9 to 42.4% (all p=0.008.Conclusions: Well structured vaccination consultations help to raise vaccination rates. Thus, pharmacies should consider offering and implementing this preventive measure so as to lower the rates of preventable disease and to save costs.

  16. Perceived vaccination status in ecotourists and risks of anthropozoonoses.

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    Muehlenbein, Michael P; Martinez, Leigh Ann; Lemke, Andrea A; Ambu, Laurentius; Nathan, Senthilvel; Alsisto, Sylvia; Andau, Patrick; Sakong, Rosman

    2008-09-01

    Anthropozoonotic (human to nonhuman animal) transmission of infectious disease poses a significant threat to wildlife. A large proportion of travelers to tropical regions are not protected against vaccine-preventable illnesses, and a majority of these travelers demonstrate poor recall of actual vaccination status. Here we characterize self-perceived vaccination status among a large sample of ecotourists at the Sepilok Orangutan Rehabilitation Centre, Sabah, Malaysia. Despite their recognized travel itinerary to view endangered animals, tourists at wildlife sanctuaries are not adequately protected against vaccine-preventable illnesses. Of 633 surveys, over half reported being currently vaccinated against tuberculosis, hepatitis A, hepatitis B, polio, and measles. Fewer participants reported current vaccination status for influenza, rabies, and chickenpox. Despite the fact that the majority of visitors to Sepilok are from temperate regions where influenza is relatively more prevalent, 67.1% of those surveyed with medical-related occupations reported not being currently vaccinated for influenza. Ecotourists concerned about environmental protection are themselves largely unaware of their potential contribution to the spread of diseases to animals. The risks of negatively affecting animal populations must be communicated to all concerned parties, and this may begin by urging travelers to examine their actual vaccination status, particularly as the ecotourism industry continues its rapid expansion, and is seen increasingly as a possible tool to save great ape populations from extinction.

  17. Perceived vaccination status in ecotourists and risks of anthropozoonoses.

    Science.gov (United States)

    Muehlenbein, Michael P; Martinez, Leigh Ann; Lemke, Andrea A; Ambu, Laurentius; Nathan, Senthilvel; Alsisto, Sylvia; Andau, Patrick; Sakong, Rosman

    2008-09-01

    Anthropozoonotic (human to nonhuman animal) transmission of infectious disease poses a significant threat to wildlife. A large proportion of travelers to tropical regions are not protected against vaccine-preventable illnesses, and a majority of these travelers demonstrate poor recall of actual vaccination status. Here we characterize self-perceived vaccination status among a large sample of ecotourists at the Sepilok Orangutan Rehabilitation Centre, Sabah, Malaysia. Despite their recognized travel itinerary to view endangered animals, tourists at wildlife sanctuaries are not adequately protected against vaccine-preventable illnesses. Of 633 surveys, over half reported being currently vaccinated against tuberculosis, hepatitis A, hepatitis B, polio, and measles. Fewer participants reported current vaccination status for influenza, rabies, and chickenpox. Despite the fact that the majority of visitors to Sepilok are from temperate regions where influenza is relatively more prevalent, 67.1% of those surveyed with medical-related occupations reported not being currently vaccinated for influenza. Ecotourists concerned about environmental protection are themselves largely unaware of their potential contribution to the spread of diseases to animals. The risks of negatively affecting animal populations must be communicated to all concerned parties, and this may begin by urging travelers to examine their actual vaccination status, particularly as the ecotourism industry continues its rapid expansion, and is seen increasingly as a possible tool to save great ape populations from extinction. PMID:18810550

  18. Status of vaccine research and development of vaccines for malaria.

    Science.gov (United States)

    Birkett, Ashley J

    2016-06-01

    Despite recent progress in reducing deaths attributable to malaria, it continues to claim approximately 500,000 lives per year and is associated with approximately 200 million infections. New tools, including safe and effective vaccines, are needed to ensure that the gains of the last 15 years are leveraged toward achieving the ultimate goal of malaria parasite eradication. In 2015, the European Medicines Agency announced the adoption of a positive opinion for the malaria vaccine candidate most advanced in development, RTS,S/AS01, which provides modest protection against clinical malaria; in early 2016, WHO recommended large-scale pilot implementations of RTS,S in settings of moderate-to-high malaria transmission. In alignment with these advancements, the community goals and preferred product characteristics for next-generation vaccines have been updated to inform the development of vaccines that are highly efficacious in preventing clinical malaria, and those needed to accelerate parasite elimination. Next-generation vaccines, targeting all stages of the parasite lifecycle, are in early-stage development with the most advanced in Phase 2 trials. Importantly, progress is being made in the definition of feasible regulatory pathways to accelerate timelines, including for vaccines designed to interrupt transmission of parasites from humans to mosquitoes. The continued absence of financially lucrative, high-income markets to drive investment in malaria vaccine development points to continued heavy reliance on public and philanthropic funding. PMID:26993333

  19. Status of vaccine research and development of vaccines for leishmaniasis.

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    Gillespie, Portia M; Beaumier, Coreen M; Strych, Ulrich; Hayward, Tara; Hotez, Peter J; Bottazzi, Maria Elena

    2016-06-01

    A number of leishmaniasis vaccine candidates are at various stages of pre-clinical and clinical development. Leishmaniasis is a vector-borne neglected tropical disease (NTD) caused by a protozoan parasite of the genus Leishmania and transmitted to humans by the bite of a sand fly. Visceral leishmaniasis (VL, kala-azar) is a high mortality NTD found mostly in South Asia and East Africa, while cutaneous leishmaniasis (CL) is a disfiguring NTD highly endemic in the Middle East, Central Asia, North Africa, and the Americas. Estimates attribute 50,000 annual deaths and 3.3 million disability-adjusted life years to leishmaniasis. There are only a few approved drug treatments, no prophylactic drug and no vaccine. Ideally, an effective vaccine against leishmaniasis will elicit long-lasting immunity and protect broadly against VL and CL. Vaccines such as Leish-F1, F2 and F3, developed at IDRI and designed based on selected Leishmania antigen epitopes, have been in clinical trials. Other groups, including the Sabin Vaccine Institute in collaboration with the National Institutes of Health are investigating recombinant Leishmania antigens in combination with selected sand fly salivary gland antigens in order to augment host immunity. To date, both VL and CL vaccines have been shown to be cost-effective in economic modeling studies. PMID:26973063

  20. Quantifying child mortality reductions related to measles vaccination.

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    Jeremy D Goldhaber-Fiebert

    Full Text Available BACKGROUND: This study characterizes the historical relationship between coverage of measles containing vaccines (MCV and mortality in children under 5 years, with a view toward ongoing global efforts to reduce child mortality. METHODOLOGY/PRINCIPAL FINDINGS: Using country-level, longitudinal panel data, from 44 countries over the period 1960-2005, we analyzed the relationship between MCV coverage and measles mortality with (1 logistic regressions for no measles deaths in a country-year, and (2 linear regressions for the logarithm of the measles death rate. All regressions allowed a flexible, non-linear relationship between coverage and mortality. Covariates included birth rate, death rates from other causes, percent living in urban areas, population density, per-capita GDP, use of the two-dose MCV, year, and mortality coding system. Regressions used lagged covariates, country fixed effects, and robust standard errors clustered by country. The likelihood of no measles deaths increased nonlinearly with higher MCV coverage (ORs: 13.8 [1.6-122.7] for 80-89% to 40.7 [3.2-517.6] for ≥95%, compared to pre-vaccination risk levels. Measles death rates declined nonlinearly with higher MCV coverage, with benefits accruing more slowly above 90% coverage. Compared to no coverage, predicted average reductions in death rates were -79% at 70% coverage, -93% at 90%, and -95% at 95%. CONCLUSIONS/SIGNIFICANCE: 40 years of experience with MCV vaccination suggests that extremely high levels of vaccination coverage are needed to produce sharp reductions in measles deaths. Achieving sustainable benefits likely requires a combination of extended vaccine programs and supplementary vaccine efforts.

  1. [Vaccination status of children in the Vienna area (author's transl)].

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    Kessler, T

    1978-12-01

    The vaccination status was investigated in 1482 patients between the ages of 1 and 14 years admitted to hospital with scarlet fever. Most of the patients were vaccinated against tuberculosis (97.7%), diphtheria, tetanus and whooping-cough (95.3%) and poliomyelitis (94.1%), relatively few against measles (21.1%) and very few indeed against mumps (0.7%) and tick-borne encephalitis (1.9%). The booster vaccination against tetanus and diphtheria had been omitted in more than 40%. Although the beneficial results of vaccination against tuberculosis, diphtheria-pertussis-tetanus and poliomyelitis remained more or less the same, the tendency towards vaccination did not spread as might have been anticipated. On the contrary, the extent of vaccination decreased, especially during the past years. In the same way the tendency towards vaccination against measles showed a sudden slowing down after a period of rapid increase. This implies that vaccination of children does not tend towards perfection. The vaccination rates differ widely between foreign children living in Vienna and natives. Although the foreigners show a similar vaccination distribution pattern as the natives, the numbers of unvaccinated children are much higher.

  2. Status of vaccine research and development of vaccines for GBS.

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    Heath, Paul T

    2016-06-01

    Streptococcus agalactiae (group B streptococcus (GBS)) is the leading cause of neonatal sepsis and meningitis in many countries. Intrapartum antibiotic strategies have reduced the incidence of early-onset neonatal GBS in a number of countries but have had no impact on late onset GBS infection (LOD). In low/middle income settings, the disease burden remains uncertain although in several countries of Southern Africa appears comparable to or higher than that of high-income countries. As disease may be rapidly fulminating cases can be missed before appropriate samples are obtained and this may lead to underestimation of the true burden. Given the rapid onset and progression within hours of birth as well as the deficiencies in IAP strategies and absence of a solution for preventing LOD, it is clear that administration of a suitable vaccine in pregnancy could provide a better solution in all settings; it should also be cost effective. The current leading vaccine candidates are CPS-protein conjugate vaccines but protein-based vaccines are also in development and one has recently commenced clinical trials. PMID:26988258

  3. AIDS vaccine: Present status and future challenges

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    Nigam P

    2006-01-01

    Full Text Available Development of a preventive vaccine for HIV is the best hope of controlling the AIDS pandemic. HIV has, however, proved a difficult pathogen to vaccinate against because of its very high mutation rate and capability to escape immune responses. Neutralizing antibodies that can neutralize diverse field strains have so far proved difficult to induce. Adjuvanting these vaccines with cytokine plasmids and a "prime-boost," approach is being evaluated in an effort to induce both CTL and antibody responses and thereby have immune responses active against both infected cells and free viral particles, thereby necessitating fewer doses of recombinant protein to reach maximum antibodies titers. Although obstacles exist in evaluation of candidate HIV vaccines, evidence from natural history studies, new molecular tools in virology and immunology, new adjuvants, new gene expression systems, new antigen delivery systems, recent discoveries in HIV entry and pathogenesis, and promising studies of candidate vaccines in animal models have provided reasons to hope that developing a safe and effective AIDS vaccine is possible and within reach.

  4. EDIBLE VACCINES FROM GM CROPS: CURRENT STATUS AND FUTURE SCOPE

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    Doshi V

    2013-06-01

    Full Text Available The idea of an edible vaccine is coming closer to reality as scientists have found a way to incorporate the protein gene with some antigen in some plants. The major hurdles in the path of an emerging vaccine technology are being overcome. In this context, genetically modified (GM plants are being investigated for the production of vaccines, antibodies and therapeutic proteins. The development of GM crops to produce drugs and vaccines has received considerable investment and is relatively well advanced. The myth surrounding edible vaccines and 'food as pill' is the difficulty to control their intake and distribution, particularly in developing countries where education levels and literacy may be low. However, this concept suffers from the fact that the potency of this class of vaccines and drugs remains unmasked to the majority of the population, which has to be publicized and campaigned in a scientific manner, to make it realistic and useful for the common man. Creating edible vaccines involves introduction of selected desired genes into plants and then inducing these altered plants to manufacture the encoded proteins. This process is known as "transformation," and the altered plants are called "transgenic plants." Like conventional subunit vaccines, edible vaccines are composed of antigenic proteins and are devoid of pathogenic genes. Thus, they have no way of establishing infection, assuring its safety, especially in immuno-compromised patients. Conventional subunit vaccines are expensive and technology-intensive, need purification, require refrigeration and produce poor mucosal response. In contrast, edible vaccines would enhance compliance, especially in children and because of oral administration, would eliminate the need for trained medical personnel. Their production is highly efficient and can be easily scaled up. If the technology is properly nurtured and given the right direction, it may usher into a new era where we will be asked to

  5. Vaccination status and sequence of vaccinations as risk factors for hospitalisation among outpatients in a high mortality country

    DEFF Research Database (Denmark)

    Biai, Sidu; Rodrigues, Amabelia; Nielsen, Jens;

    2011-01-01

    Most developing countries are implementing the WHO immunisation programme. Although vaccines reach most children, many modifications of the recommended schedule are observed in practice. We investigated the association between vaccination status and risk of hospitalisation in Guinea-Bissau....

  6. Paternal education status significantly influences infants’ measles vaccination uptake, independent of maternal education status

    OpenAIRE

    Rammohan Anu; Awofeso Niyi; Fernandez Renae C

    2012-01-01

    Abstract Background Despite increased funding of measles vaccination programs by national governments and international aid agencies, structural factors encumber attainment of childhood measles immunisation to levels which may guarantee herd immunity. One of such factors is parental education status. Research on the links between parental education and vaccination has typically focused on the influence of maternal education status. This study aims to demonstrate the independent influence of p...

  7. Language of perfectionistic parents predicting child anxiety diagnostic status.

    Science.gov (United States)

    Affrunti, Nicholas W; Geronimi, Elena M C; Woodruff-Borden, Janet

    2015-03-01

    Previous research has identified parental perfectionism as a risk factor for child anxiety. Yet few studies investigated why parental perfectionism may play such a role. Based on research suggesting parental verbal information and language use are associated with increased child fear beliefs and anxiety, the current study investigated the linguistic style of perfectionistic mothers and its relation to child anxiety. Participants were 71 mother-child dyads. Children were 3-12 years old, 57.7% female, and 30 were diagnosed with an anxiety disorder. Analyses showed that parental perfectionism was associated with increased second person pronouns, decreased adverbs, negative emotion words, and anger words. Second person pronouns and negative emotion words predicted child anxiety diagnostic status and mediated the relation between maternal perfectionism and child anxiety. These findings suggest that parental perfectionism may be associated with a specific language style that is related to child anxiety. Implications and future directions are discussed.

  8. The Child's Status in the Democratic State

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    Schrag, Francis

    1975-01-01

    Examines and questions the child and universal adult suffrage, justifying the child's exclusion, establishing criteria for voter competence, evaluating the competence of children, and chronological age as a criterion. Journal available from Sage Publications, Inc., 275 South Beverly Drive, Beverly Hills, California 90212. (ND)

  9. Maternal Attachment Status, Mother-Child Emotion Talk, Emotion Understanding, and Child Conduct Problems

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    Brad M. Farrant

    2013-01-01

    Full Text Available Conduct problems that emerge in childhood often persist into adolescence and are associated with a range of negative outcomes. It is therefore important to identify the factors that predict conduct problems in early childhood. The present study investigated the relations among maternal attachment status, mother-child emotion talk, child emotion understanding, and conduct problems in a sample of 92 (46 males typically developing children (M age = 61.3 months, SD = 8.3 months. The results support a model in which maternal attachment status predicts the level of appropriate/responsive mother-child emotion talk, which predicts child emotion understanding, which in turn negatively predicts child conduct problems. These findings further underline the developmental role of mother-child emotion talk as well as the importance of involving parents in programs designed to increase children’s emotion understanding and/or decrease the incidence of conduct problems.

  10. Anti-nicotine vaccine: current status

    Directory of Open Access Journals (Sweden)

    Vishal Prakash Giri

    2015-12-01

    Full Text Available Tobacco abuse has an enormous impact on health. Nicotine is the main substance responsible for dependence on tobacco-containing products. The vast majority of cigarette smokers who try to quit ultimately fail because of high relapse rates. Clearly, novel approaches are needed for the treatment and prevention of nicotine addiction. Having an efficient vaccine that would generate antibodies to sequester the drug and prevent its access to the brain could go a long way toward helping a motivated addict quit an addiction. [Int J Basic Clin Pharmacol 2015; 4(6.000: 1309-1313

  11. STATUS OF THE CHILD LABOR IN TURKEY

    Directory of Open Access Journals (Sweden)

    Hacer TOR

    2010-08-01

    Full Text Available This paper analyzes numerical data and sectoral distribution relating to child labor in Turkey. The information is taken the labor force research data collected by the Turkish Statistical Institute. Several attempts have been made to resolve the problems of child workers in Turkey. The first stage was the implementation of the International Program on the Elimination of Child Labor (ILO/IPEC. After introduction of the program, many organizations started various activities directed towards children workers in Turkey. Since these initiatives were coordinated and complementary activities there were remarkable developments in the fight against problems of the child workers. The Turkish Statistical Institute examined the child labor force proportion by means of three separate statistical components and the results revealed that number of the child workers has a tendency to decrease. Despite some statistical research carried out in Turkey, the precise number of children that are working cannot be determined. Some of the leading factors can be listed as paucity of research carried out in this area, inaccurate official statistical data regarding the number of children who are working illegally, employed as unpaid family workers, working in the streets, working on the temporary or seasonal basis, and other related factors.

  12. Association between maternal health literacy and child vaccination in India: a cross-sectional study

    OpenAIRE

    Johri, Mira; Subramanian, S. V.; Sylvestre, Marie-Pierre; Dudeja, Sakshi; Chandra, Dinesh; Koné, Georges K; Sharma, Jitendar K; Pahwa, Smriti

    2015-01-01

    Background Education of mothers may improve child health. We investigated whether maternal health literacy, a rapidly modifiable factor related to mother's education, was associated with children's receipt of vaccines in two underserved Indian communities. Methods Cross-sectional surveys in an urban and a rural site. We assessed health literacy using Indian child health promotion materials. The outcome was receipt of three doses of diphtheria-tetanus-pertussis (DTP3) vaccine. We used multivar...

  13. Neurogenic pulmonary edema in a child with status epilepticus

    Directory of Open Access Journals (Sweden)

    Bindu T Nair

    2016-01-01

    Full Text Available Neurogenic pulmonary edema (NPE is defined as acute pulmonary edema after a sudden neurologic insult. It develops after a significant central nervous system insult such as trauma, hemorrhage or seizures and can occur both in adults and children. A 6-year-old male child, known case of cerebral palsy was brought to the emergency department in status epilepticus. He had severe respiratory distress with pink frothy secretions pouring from the mouth. Clinical and radiological examination was suggestive of NPE. Child was immediately ventilated and all supportive measures were started. Child showed marked improvement within 48 h of admission with diuresis and positive end-expiratory pressure (PEEP assisted ventilation.

  14. The Girl Child : An Exposition Of Their Status

    OpenAIRE

    Senapati S.K; Bhattacharya S.; Das D.K

    1990-01-01

    The age of 0-15 years is crucial in terms of health, growth and development for a girl. Discriminations against the girl child start from birth and continue throughout the life of women. Socio- cultural factors compound the problem thus lowering the status of women in society. The present study was conducted in 8 villages of south 24 Parganas of West Bengal to recognize the status and problem of the girl child in a given socio- cultural reality. Using a multi- stage sampling procedure, 438 ho...

  15. Current vaccination status regarding measles among university students in Dresden, Germany.

    Science.gov (United States)

    Riemenschneider, Henna; Schübel, Jeannine; Bergmann, Antje; Kugler, Joachim; Voigt, Karen

    2015-12-01

    Germany aimed to eliminate measles by 2015, but vaccination coverage is still insufficient, especially in respect to adolescents and young adults. A cross-sectional survey with 711 students studying a range of subjects showed a high acceptance regarding vaccination. Actual self-reported vaccination rates were lower; only 65.5% of medical students and 25.3%-39.4% of other student groups reported complete vaccination against measles. Of the students, 12.6%-45% did not know their vaccination status. Vaccination acceptance did not correlate with vaccination behavior: accessible vaccination opportunities at universities should be offered.

  16. Post Approval Human Papillomavirus Vaccine Uptake Is Higher in Minorities Compared to Whites in Girls Presenting for Well-Child Care

    Directory of Open Access Journals (Sweden)

    Susan C. Modesitt

    2013-07-01

    Full Text Available Since introduction of the human papillomavirus (HPV vaccine, there remains low uptake compared to other adolescent vaccines. There is limited information postapproval about parental attitudes and barriers when presenting for routine care. This study evaluates HPV vaccine uptake and assesses demographics and attitudes correlating with vaccination for girls aged 11–12 years. A prospective cohort study was performed utilizing the University of Virginia (UVA Clinical Data Repository (CDR. The CDR was used to identify girls aged 11–12 presenting to any UVA practice for a well-child visit between May 2008 and April 2009. Billing data were searched to determine rates of HPV vaccine uptake. The parents of all identified girls were contacted four to seven months after the visit to complete a telephone questionnaire including insurance information, child’s vaccination status, HPV vaccine attitudes, and demographics. Five hundred and fifty girls were identified, 48.2% of whom received at least one HPV vaccine dose. White race and private insurance were negatively associated with HPV vaccine initiation (RR 0.72, 95% CI 0.61–0.85 and RR 0.85, 95% CI 0.72–1.01, respectively. In the follow-up questionnaire, 242 interviews were conducted and included in the final cohort. In the sample, 183 (75.6% parents reported white race, 38 (15.7% black race, and 27 (11.2% reported other race. Overall 85% of parents understood that the HPV vaccine was recommended and 58.9% of parents believed the HPV vaccine was safe. In multivariate logistic regression, patients of black and other minority races were 4.9 and 4.2 times more likely to receive the HPV vaccine compared to their white counterparts. Safety concerns were the strongest barrier to vaccination. To conclude, HPV vaccine uptake was higher among minority girls and girls with public insurance in this cohort.

  17. Maternal Attachment Status, Mother-Child Emotion Talk, Emotion Understanding, and Child Conduct Problems

    OpenAIRE

    Brad M. Farrant; Maybery, Murray T.; Janet Fletcher

    2013-01-01

    Conduct problems that emerge in childhood often persist into adolescence and are associated with a range of negative outcomes. It is therefore important to identify the factors that predict conduct problems in early childhood. The present study investigated the relations among maternal attachment status, mother-child emotion talk, child emotion understanding, and conduct problems in a sample of 92 (46 males) typically developing children (M age = 61.3 months, SD = 8.3 months). The results sup...

  18. The Girl Child : An Exposition Of Their Status

    Directory of Open Access Journals (Sweden)

    Senapati S.K

    1990-01-01

    Full Text Available The age of 0-15 years is crucial in terms of health, growth and development for a girl. Discriminations against the girl child start from birth and continue throughout the life of women. Socio- cultural factors compound the problem thus lowering the status of women in society. The present study was conducted in 8 villages of south 24 Parganas of West Bengal to recognize the status and problem of the girl child in a given socio- cultural reality. Using a multi- stage sampling procedure, 438 households with 1377 children (870 girls and 507 boys of 0-15 years age- group were selected for collecting data on children’s health, nutrition, education, work pattern and mother’s opinion regarding issues related to the girl child.

  19. Status of vaccine research and development of vaccines for HIV-1.

    Science.gov (United States)

    Safrit, Jeffrey T; Fast, Patricia E; Gieber, Lisa; Kuipers, Hester; Dean, Hansi J; Koff, Wayne C

    2016-06-01

    Human immunodeficiency virus (HIV) is the cause of one of the most lethal pandemics in human history, although in recent years access to highly effective anti-retroviral therapy has provided new hope worldwide. Transmission of HIV by sexual contact, childbirth and injection drug use has been reduced, but 2 million are newly infected each year, and much of the transmission is from people who do not know their status. In addition to known methods, a preventive vaccine is needed to end the pandemic. The extraordinary mutability and genetic diversity of HIV is an enormous challenge, but vaccines are being designed for broad coverage. Computer-aided design of mosaic immunogens, incorporating many epitopes from the entire genome or from conserved regions aim to induce CD8+ T cells to kill virus-infected cells or inhibit virus replication, while trimeric envelope proteins or synthetic mimics aim to induce broadly reactive neutralizing antibodies similar to those cloned from some infected patients. Induction of more potent and durable responses may require new adjuvants or replicating chimeric vectors chimeras that bear HIV genes. Passive or genetic delivery of broadly neutralizing antibodies may provide broad protection and/or lead to insights for vaccine designers. Proof-of-concept trials in non-human primates and in one human efficacy trial have provided scientific clues for a vaccine that could provide broad and durable protection against HIV. The use of vaccines to destroy HIV reservoirs as part of therapy or cure is now also being explored. PMID:26993335

  20. Effects of integrated child development and nutrition interventions on child development and nutritional status.

    Science.gov (United States)

    Grantham-McGregor, Sally M; Fernald, Lia C H; Kagawa, Rose M C; Walker, Susan

    2014-01-01

    We conducted a systematic review of studies that examined the effect of interventions combining a child development component with a nutrition one; in some cases the nutrition interventions also included health-promotion components. Only papers with both child development and nutrition outcomes and rated as moderate-to-good quality were included. Eleven efficacy and two nonrandomized trials, and eight program evaluations were identified. Only six trials examined interventions separately and combined. The trials showed nutritional interventions usually benefited nutritional status and sometimes benefited child development. Stimulation consistently benefited child development. There was no significant loss of any effect when interventions were combined, but there was little evidence of synergistic interaction between nutrition and stimulation on child development. Only three trials followed up the children after intervention. All at-scale program evaluations were combined interventions. Five benefited child development, but one did not, and two showed deficits. There was generally little benefit of at-scale programs to nutritional status. We found no rigorous evaluations of adding stimulation to health and nutrition services at scale and there is an urgent need for them. There is also a need to establish quality-control mechanisms for existing scaled-up programs and to determine their long-term effects. There is also a need to determine if there are any sustained benefits for the children after programs finish.

  1. The decision to vaccinate a child: an economic perspective from southern Malawi.

    Science.gov (United States)

    Holte, Jon H; Mæstad, Ottar; Jani, Jagrati V

    2012-07-01

    The dynamics of childhood vaccination uptake in developing countries are unclear. Numerous studies document the relationship between vaccination coverage and access, socio economic and demographic factors. However, there is less knowledge about the relationship between vaccination coverage and carers' motivation and willingness to seek childhood vaccinations. The aim of this paper is to introduce a framework for studying demand for childhood vaccination and to examine the coherence between theoretical predictions and empirical findings in a rural area in Malawi. We interviewed 635 carers with children aged 18-59 months. About 96 percent of the respondents reported to have fully vaccinated their youngest eligible child for all routine vaccinations scheduled in the Expanded Program on Immunization. This paper concludes that easy access to vaccination services cannot explain why demand is high. Many carers had to travel long distances to reach vaccination delivery points and a considerable share of the respondents scored waiting and travelling time as long. Results from the present study, in combination with theoretical predictions, suggest that a high level of trust in distributors of information and vaccines may be an essential explanatory factor for why carers seek immunization for their children, even in the presence of considerable costs. Trust may be an important explanatory factor as it can be seen to generate positive perceived benefits. PMID:22571892

  2. How does socio-economic status shape a child's personality?

    OpenAIRE

    Deckers, Thomas; Falk, Armin; Kosse, Fabian; Schildberg-Hörisch, Hannah

    2015-01-01

    We show that socio-economic status (SES) is a powerful predictor of many facets of a child's personality. The facets of personality we investigate encompass time preferences, risk preferences, and altruism, as well as crystallized and fluid IQ. We measure a family's SES by the mother's and father's average years of education and household income. Our results show that children from families with higher SES are more patient, tend to be more altruistic and less likely to be risk seeking, and sc...

  3. Neurogenic pulmonary edema in a child with status epilepticus

    OpenAIRE

    Bindu T Nair; Sajith Surendran; Dinesh Yadav

    2016-01-01

    Neurogenic pulmonary edema (NPE) is defined as acute pulmonary edema after a sudden neurologic insult. It develops after a significant central nervous system insult such as trauma, hemorrhage or seizures and can occur both in adults and children. A 6-year-old male child, known case of cerebral palsy was brought to the emergency department in status epilepticus. He had severe respiratory distress with pink frothy secretions pouring from the mouth. Clinical and radiological examination was sugg...

  4. Parent Perception of Provider Interactions Influences HPV Vaccination Status of Adolescent Females.

    Science.gov (United States)

    Clark, Sarah J; Cowan, Anne E; Filipp, Stephanie L; Fisher, Allison M; Stokley, Shannon

    2016-07-01

    Human papillomavirus (HPV) vaccination coverage among adolescent females is well below national public health goals. Many known barriers to HPV vaccine receipt can be addressed in parent-physician conversations. This study sought to explore parent experiences and attitudes related to HPV vaccination of adolescent girls, focused on interactions with providers. We conducted a cross-sectional survey of parents using a nationally representative online panel. Among parents with ≥1 daughter aged 11 to 17 years, provider recommendations for HPV vaccine and specified age to begin the HPV vaccine series were associated with HPV vaccine status. Parents who reported their daughters were unlikely to complete the HPV series were more likely to have had no discussion of HPV vaccine with the provider. Efforts to increase HPV vaccination rates among adolescent females should continue to focus on improving provider discussion of HPV vaccine. PMID:26450982

  5. RTS,S/AS01 malaria vaccine and child mortality

    DEFF Research Database (Denmark)

    Aaby, Peter; Rodrigues, Amabelia; Kofoed, Poul-Erik;

    2015-01-01

    Comment on Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. [Lancet. 2015]......Comment on Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. [Lancet. 2015]...

  6. How do parents make their decision about letting their child get a BCG vaccination?

    DEFF Research Database (Denmark)

    Thybo Pihl, Gitte; Ammentorp, Jette; Schmidt Jensen, Jane;

    of illness and atopic diseases in their personal network and family to evaluate risk for their child to develop atopic diseases or get hospitalised. This lay epidemiologi forms the basis for their decision. Davison C, Frankel S, Davey Smith G. Inheriting heart trouble: the relevance of common-sense ideas......Introduction: In a large prospective randomised clinical trial in Denmark we are testing the hypothesis that compared to non-BCG-vaccinated infants, infants who are BCG vaccinated at birth experience less hospitalisations, use less antibiotics, and develop less atopic disease in early childhood. My...... focus for this project is parents decision making and risk evaluation. I want to investigate how parents make their decision about letting their child get a BCG vaccination and how they evaluate the risk of side effects. Method: Before the clinical trial was started, we conducted 5 focus groups...

  7. Vaccination coverage in French 17-year-old young adults: an assessment of mandatory and recommended vaccination statuses.

    Science.gov (United States)

    Roblot, F; Robin, S; Chubilleau, C; Giraud, J; Bouffard, B; Ingrand, P

    2016-02-01

    We aimed to assess vaccination coverage (VC) in 17-year-old French young adults (YAs) participating in one mandatory Day of Defence and Citizenship (DDC). Between June 2010 and May 2011, YAs participating in 43 randomly selected mandatory sessions of the DDC programme in Poitou-Charentes (France) were asked to provide their personal vaccination record. Tetanus, diphtheria, polio, hepatitis B, Haemophilus influenzae b, pertussis, measles, mumps and rubella vaccination status were assessed at ages 2, 6, 13 and 17 years. Of 2610 participants, 2111 (81%) supplied documents for evaluation. Of these, 1838 (87%, M:F sex ratio 0·96) were aged 17 years (9% of the global population of this age in the area). The assessment of the 17-year-olds demonstrated the following rates of complete vaccination: diphtheria-tetanus-polio 83%; measles, mumps and rubella 83%; pertussis 69%; H. influenzae b 61%; human papillomavirus 47%; and hepatitis B 40%. At age 6 years, only 46% had received two doses of the vaccine against measles. The YAs were not aware of their status but were in favour of vaccination. VC in YAs is insufficient, particularly for hepatitis B, pertussis and measles. Combined vaccines and the simplification of vaccination schedules should improve VC. Preventive messages should focus on YAs.

  8. Selenium status during pregnancy and child psychomotor development—Polish Mother and Child Cohort study

    Science.gov (United States)

    Polanska, Kinga; Krol, Anna; Sobala, Wojciech; Gromadzinska, Jolanta; Brodzka, Renata; Calamandrei, Gemma; Chiarotti, Flavia; Wasowicz, Wojciech; Hanke, Wojciech

    2016-01-01

    Background: The studies on the impact of selenium (Se) levels in different pregnancy periods on child psychomotor functions are limited. The aim of this study was to evaluate the impact of prenatal Se on child neurodevelopment. Methods: The study population consisted of 410 mother–child pairs from Polish Mother and Child Cohort. Se levels were measured in each trimester of pregnancy, at delivery, and in cord blood by graphite furnace atomic absorption spectrometry. Psychomotor development was assessed in children at the age of 1 and 2 y using the Bayley Scales of Infant and Toddler Development. Results: Plasma Se levels decreased through pregnancy (from 48.3 ± 10.6 µg/l in the first trimester to 38.4 ± 11.8 µg/l at delivery; P < 0.05). A statistically significant positive association between Se levels in the first trimester of pregnancy and motor development (β = 0.2, P = 0.002) at 1 y of age, and language development (β = 0.2, P = 0.03) at 2 y of age was observed. The positive effect of Se levels on cognitive score at 2 y of age was of borderline significance (β = 0.2, P = 0.05). Conclusion: Prenatal selenium status was associated with child psychomotor abilities within the first years of life. Further epidemiological and preclinical studies are needed to confirm the association and elucidate the underlying mechanisms of these effects. PMID:26885758

  9. Dengue vaccines: Challenges, development, current status and prospects

    Directory of Open Access Journals (Sweden)

    A Ghosh

    2015-01-01

    Full Text Available Infection with dengue virus (DENV is the most rapidly spreading mosquito-borne viral disease in the world. The clinical spectrum of dengue, caused by any of the four serotypes of DENV, ranges from mild self-limiting dengue fever to severe dengue, in the form dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. Increased rates of hospitalization due to severe dengue, during outbreaks, result in massive economic losses and strained health services. In the absence of specific antiviral therapy, control of transmission of DENV by vector management is the sole method available for decreasing dengue-associated morbidity. Since vector control strategies alone have not been able to satisfactorily achieve reduction in viral transmission, the implementation of a safe, efficacious and cost-effective dengue vaccine as a supplementary measure is a high public health priority. However, the unique and complex immunopathology of dengue has complicated vaccine development. Dengue vaccines have also been challenged by critical issues like lack of animal models for the disease and absence of suitable markers of protective immunity. Although no licensed dengue vaccine is yet available, several vaccine candidates are under phases of development, including live attenuated virus vaccines, live chimeric virus vaccines, inactivated virus vaccines, subunit vaccines, DNA vaccines and viral-vectored vaccines. Although some vaccine candidates have progressed from animal trials to phase II and III in humans, a number of issues regarding implementation of dengue vaccine in countries like India still need to be addressed. Despite the current limitations, collaborative effects of regulatory bodies like World Health Organization with vaccine manufacturers and policy makers, to facilitate vaccine development and standardize field trials can make a safe and efficacious dengue vaccine a reality in near future.

  10. Parental Vaccine Hesitancy in Quebec (Canada)

    Science.gov (United States)

    Dubé, Eve; Gagnon, Dominique; Zhou, Zhou; Deceuninck, Genevieve

    2016-01-01

    Introduction: "Vaccine hesitancy" is a concept frequently used in the discourse around vaccine acceptance. This study aims to contribute to the ongoing reflections on tools and indicators of vaccine hesitancy by providing results of a knowledge, attitudes and beliefs (KAB) survey conducted among parents. Methods: Data were collected in 2014 through a computer-assisted telephone interview survey administered to a sample of parents of children aged between 2 months and 17 years of age. Results: The majority of the 589 parents included in the analyses agreed on the importance of vaccination to protect their children’s health and to prevent the spread of diseases in the community. The majority of the parents (81%) reported that their child had received all doses of recommended vaccines and 40% of parents indicated having hesitated to have their child vaccinated. Fear of adverse events and low perceived vulnerability of the child or severity of the disease were the most frequent reasons mentioned by these vaccine-hesitant parents. In multivariate analyses, KAB items remaining significantly associated both with an incomplete vaccination status of the child and parents’ vaccine hesitancy were: not thinking that it is important to have the child vaccinated to prevent the spreading of diseases in the community; not trusting the received vaccination information and having felt pressure to have the child vaccinated. Discussion: Further researches will be needed to better understand when, how and why these beliefs are formed in order to prevent the onset of vaccine hesitancy. PMID:27019766

  11. Mantoux test results and BCG vaccination status in TB-exposed children

    OpenAIRE

    Fadilah Harahap; Ridwan M. Daulay; Muhammad Ali; Wisman Dalimunthe; Rini Savitri Daulay

    2016-01-01

    Background Tuberculosis (TB) infection is highly prevalent in Indonesia. The source of transmission of TB to a child is usually via an adult with sputum smear-positive pulmonary tuberculosis. The Mantoux test is a diagnostic tool for tuberculosis infection. The BCG vaccine has been used for the prevention of TB, but its efficacy is still debated. Objective To assess for an association between Mantoux test results and BCG vaccination in children who had contact with adult pulmonary tuberculosi...

  12. Differentials in reproductive and child health status in India

    Directory of Open Access Journals (Sweden)

    Nikhilesh Parchure

    2011-12-01

    Full Text Available

    Background: Inequalities in reproductive and child health (RCH exist, in general, in different regions of India. The present study aims to investigate the current status of RCH and examine the factors responsible for it in different parts of India.

    Methods: This study utilized data obtained from two Indian studies – (i National Family Health Survey – 3 (NFHS- 2005-06 and (ii District Level Household Survey (DLHS – 2002-04. Reproductive Health Index was computed on the basis of five variables such as total fertility rate, infant mortality rate, birth order, delivery care and female educational attainment.

    Results: In terms of reproductive and child health, a wide range of variation exists in India in its different regions. The study reveals that among Indian states, 13 states have an index value less than the national average. On the basis of the reproductive health index, the Indian states can be divided into three categories, namely; progressive states, semi progressive states and backward states.

    Conclusions: The interstate differences in healthcare utilization are partly due to variations in the implementation of maternal health care programs as well as differences in availability of and accessibility to healthcare between Indian states.

  13. Status of research and development of vaccines for Streptococcus pyogenes.

    Science.gov (United States)

    Steer, Andrew C; Carapetis, Jonathan R; Dale, James B; Fraser, John D; Good, Michael F; Guilherme, Luiza; Moreland, Nicole J; Mulholland, E Kim; Schodel, Florian; Smeesters, Pierre R

    2016-06-01

    Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates. PMID:27032515

  14. Effect of feeding whole compared with cell-free colostrum on calf immune status: Vaccination response.

    Science.gov (United States)

    Langel, S N; Wark, W A; Garst, S N; James, R E; McGilliard, M L; Petersson-Wolfe, C S; Kanevsky-Mullarky, I

    2016-05-01

    Vaccination contributes to improved herd health and production. Boosting immune development at a young age may have long-term effects by enhancing vaccine immune response and efficacy. In the bovine, colostrum is the sole source of maternal immunity, having a substantial effect on health status in the neonate. To date, colostral antibody concentration is used to evaluate colostrum quality. However, colostrum also contains proteins and cells, which may affect immune development and future responses to vaccines. To determine the effect of maternal colostral cells on immune development, 37 female Holstein and Jersey dairy calves were bottle-fed 4 quarts total of whole colostrum (WC) or cell-free colostrum (CFC) at birth. Calves were vaccinated with 2 series of multivalent vaccines. Series A consisted of vaccines given between 1 and 4mo of life. Series B consisted of vaccines given between 5 and 10mo of life. Calf peripheral blood samples were obtained before each vaccination series and monthly for 3mo after each vaccination series. Cellular blood parameters were determined by flow cytometry. Quantitative real-time PCR was used to determine cytokine gene expression in peripheral blood mononuclear cells before vaccination series B and once a month for 2mo after vaccination series B. Calves fed CFC had fewer numbers of B cells in mo 2 after vaccination series A when compared with WC-fed calves. Calves fed CFC had decreased gene expression levels of IL-2 in mo 1 and numbers of CD4(+)CD62L(+)CD45RO(-) and CD4(+)CD62L(+)CD45RO(+) T cells in mo 0 and 1 after vaccination series B as compared with WC-fed calves. Our findings indicate a greater response to vaccines up to 6 to 10mo post-WC feeding when compared with CFC. These data suggest that adoptive transfer of maternal colostral cells at birth has a long-term effect on development of the neonatal immune system. PMID:26923041

  15. Effect of feeding whole compared with cell-free colostrum on calf immune status: Vaccination response.

    Science.gov (United States)

    Langel, S N; Wark, W A; Garst, S N; James, R E; McGilliard, M L; Petersson-Wolfe, C S; Kanevsky-Mullarky, I

    2016-05-01

    Vaccination contributes to improved herd health and production. Boosting immune development at a young age may have long-term effects by enhancing vaccine immune response and efficacy. In the bovine, colostrum is the sole source of maternal immunity, having a substantial effect on health status in the neonate. To date, colostral antibody concentration is used to evaluate colostrum quality. However, colostrum also contains proteins and cells, which may affect immune development and future responses to vaccines. To determine the effect of maternal colostral cells on immune development, 37 female Holstein and Jersey dairy calves were bottle-fed 4 quarts total of whole colostrum (WC) or cell-free colostrum (CFC) at birth. Calves were vaccinated with 2 series of multivalent vaccines. Series A consisted of vaccines given between 1 and 4mo of life. Series B consisted of vaccines given between 5 and 10mo of life. Calf peripheral blood samples were obtained before each vaccination series and monthly for 3mo after each vaccination series. Cellular blood parameters were determined by flow cytometry. Quantitative real-time PCR was used to determine cytokine gene expression in peripheral blood mononuclear cells before vaccination series B and once a month for 2mo after vaccination series B. Calves fed CFC had fewer numbers of B cells in mo 2 after vaccination series A when compared with WC-fed calves. Calves fed CFC had decreased gene expression levels of IL-2 in mo 1 and numbers of CD4(+)CD62L(+)CD45RO(-) and CD4(+)CD62L(+)CD45RO(+) T cells in mo 0 and 1 after vaccination series B as compared with WC-fed calves. Our findings indicate a greater response to vaccines up to 6 to 10mo post-WC feeding when compared with CFC. These data suggest that adoptive transfer of maternal colostral cells at birth has a long-term effect on development of the neonatal immune system.

  16. Impact of subsidies and socioeconomic status on varicella vaccination in Greater Tokyo, Japan

    Directory of Open Access Journals (Sweden)

    Kei eNagaoka

    2016-03-01

    Full Text Available Background: Although the control of varicella outbreaks is an important health issue, cost could present a major barrier for vaccination The aim of this study is to investigate the association of vaccine subsidies and caregivers’ socioeconomic status with varicella vaccine coverage of their children in Greater Tokyo, Japan, before the period that varicella vaccination was included as routine immunization program.Methods: Participants were recruited from two different cities. In Chiba city, parents of 18-month-old infants (N = 378 undergoing a medical examination in July 2013 were recruited at a clinic where no subsidy for varicella immunization was provided. In Nishitokyo city, parents of 24- to 30-month-old children (N=315 undergoing a health check-up in July and August 2013 were recruited at a clinic where a partial subsidy was provided. The association between household income and varicella immunization was investigated by multivariate logistic regression stratified by city.Results: Vaccine coverage was 61.0% in Chiba city and 73.3% in Nishitokyo city. In Chiba city, odds ratios of middle and high household income for varicella immunization were 4.22 (95% CI (confidence interval: 1.65-10.7 and 5.94 (95% CI: 1.89-18.6 compared to low household income, respectively. However, household income was not associated with varicella vaccination in Nishitokyo city. Neither working status nor education was associated with vaccination in both cities. Conclusions: While household income was associated with high vaccine coverage in the city with no vaccine subsidy, this association was not observed in the city where the subsidy was given, which suggests that cost is a barrier for varicella immunization.Thus, in countries where varicella vaccination is not included in routine immunization program, introducing subsidies nationwide or routine immunization programs for varicella vaccination would be an important approach to eliminate inequality in vaccine

  17. Status of vaccine research and development for Shigella.

    Science.gov (United States)

    Mani, Sachin; Wierzba, Thomas; Walker, Richard I

    2016-06-01

    Shigella are gram-negative bacteria that cause severe diarrhea and dysentery. In 2013, Shigella infections caused an estimated 34,400 deaths in children less than five years old and, in 2010, an estimated 40,000 deaths in persons older than five years globally. New disease burden estimates from newly deployed molecular diagnostic assays with increased sensitivity suggest that Shigella-associated morbidity may be much greater than previous disease estimates from culture-based methods. Primary prevention of this disease should be based on universal provision of potable water and sanitation methods and improved personal and food hygiene. However, an efficacious and low-cost vaccine would complement and accelerate disease reduction while waiting for universal access to water, sanitation, and hygiene improvements. This review article provides a landscape of Shigella vaccine development efforts. No vaccine is yet available, but human and animal challenge-rechallenge trials with virulent Shigella as well as observational studies in Shigella-endemic areas have shown that the incidence of disease decreases following Shigella infection, pointing to biological feasibility of a vaccine. Immunity to Shigella appears to be strain-specific, so a vaccine that covers the most commonly detected strains (i.e., S. flexneri 2a, 3a, 6, and S. sonnei) or a vaccine using cross-species conserved antigens would likely be most effective. Vaccine development and testing may be accelerated by use of animal models, such as the guinea pig keratoconjunctivitis or murine pneumonia models. Because there is no correlate of protection, however, human studies will be necessary to evaluate vaccine efficacy prior to deployment. A diversity of Shigella vaccine constructs are under development, including live attenuated, formalin-killed whole-cell, glycoconjugate, subunit, and novel antigen vaccines (e.g., Type III secretion system and outer membrane proteins). PMID:26979135

  18. Q Fever Knowledge, Attitudes and Vaccination Status of Australia's Veterinary Workforce in 2014.

    Directory of Open Access Journals (Sweden)

    Emily Sellens

    Full Text Available Q fever, caused by Coxiella burnetii, is a serious zoonotic disease in humans with a worldwide distribution. Many species of animals are capable of transmitting C. burnetii, and consequently all veterinary workers are at risk for this disease. An effective Q fever vaccine has been readily available and used in Australia for many years in at-risk groups, and the European Centre for Disease Prevention and Control has recently also called for the use of this vaccine among at-risk groups in Europe. Little is known about attitudes towards this vaccine and vaccine uptake in veterinary workers. This study aimed to determine the Q fever vaccination status of veterinarians and veterinary nurses in Australia and to assess and compare the knowledge and attitudes towards Q fever disease and vaccination of each cohort. An online cross-sectional survey performed in 2014 targeted all veterinarians and veterinary nurses in Australia. Responses from 890 veterinarians and 852 veterinary nurses were obtained. Binary, ordinal and multinomial logistic regression were used to make comparisons between the two cohorts. The results showed that 74% of veterinarians had sought vaccination compared to only 29% of veterinary nurses. Barriers to vaccination among those not vaccinated did not differ between cohorts, and included a lack of perceived risk, financial expense, time constraints, and difficulty in finding a vaccine provider. Poor knowledge and awareness of Q fever disease and vaccination were additional and notable barriers for the veterinary nursing cohort, suggesting veterinary clinics and veterinarians may not be meeting their legal responsibility to educate staff about risks and risk prevention. Further evaluation is needed to identify the drivers behind seeking and recommending vaccination so that recommendations can be made to improve vaccine uptake.

  19. Meningococcal Vaccine (For Parents)

    Science.gov (United States)

    ... Palsy: Shannon's Story" 5 Things to Know About Zika & Pregnancy Your Child's Immunizations: Meningococcal Vaccines KidsHealth > For Parents > Your Child's Immunizations: Meningococcal Vaccines ...

  20. Status of paratyphoid fever vaccine research and development.

    Science.gov (United States)

    Martin, Laura B; Simon, Raphael; MacLennan, Calman A; Tennant, Sharon M; Sahastrabuddhe, Sushant; Khan, M Imran

    2016-06-01

    Salmonella enterica serovars Typhi and Paratyphi (S. Paratyphi) A and B cause enteric fever in humans. Of the paratyphoid group, S. Paratyphi A is the most common serovar. In 2000, there were an estimated 5.4 million cases of S. Paratyphi A worldwide. More recently paratyphoid fever has accounted for an increasing fraction of all cases of enteric fever. Although vaccines for typhoid fever have been developed and in use for decades, vaccines for paratyphoid fever have not yet been licensed. Several S. Paratyphi A vaccines, however, are in development and based on either whole cell live-attenuated strains or repeating units of the lipopolysaccharide O-antigen (O:2) conjugated to different protein carriers. An O-specific polysaccharide (O:2) of S. Paratyphi A conjugated to tetanus toxoid (O:2-TT), for example, has been determined to be safe and immunogenic after one dose in Phase I and Phase II trials. Two other conjugated vaccine candidates linked to diphtheria toxin and a live-attenuated oral vaccine candidate are currently in preclinical development. As promising vaccine candidates are advanced along the development pipeline, an adequate supply of vaccines will need to be ensured to meet growing demand, particularly in the most affected countries.

  1. Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients

    Directory of Open Access Journals (Sweden)

    Jaromír Eiselt

    2016-02-01

    Full Text Available Background/Aims: The immune response to influenza vaccine may be influenced by many factors, e.g. age, comorbidities or inflammation, and iron status. Methods: We studied the vaccine-induced production of hemagglutination-inhibition antibodies (HI in 133 hemodialysis patients (HD and 40 controls. To identify variables associated with the immune response, uni- and multivariate regression analyses were performed with seroconversion in HI titers as a dependent variable, with demographics, comorbidities, previous vaccination, inflammation, and iron status as independent variables. Results: Seroconversion rates were lower in HD than in controls [43% versus 73% (H1N1 strain; p Conclusion: The influenza vaccine-induced antibody production was lower in HD than in controls and was independent of inflammation and iron status in both groups. Besides dependence on dialysis, the variables associated with inferior seroconversion rates included pre-vaccination seroprotection, previous vaccination, and old age.

  2. Influenza and pneumococcal vaccination and varicella status in inflammatory arthritis patients.

    LENUS (Irish Health Repository)

    McCarthy, E M

    2011-11-15

    Patients with inflammatory arthritis are at increased risk of vaccine preventable infections. This risk is increased by immunomodulatory therapies. Vaccination for influenza and pneumococcal disease reduces the risk. Severe cases of varicella infection have occurred in patients on biologic therapies. We sought to identify vaccination rates for commonly acquired infections and to ascertain varicella immune status in patients with inflammatory arthritis. 100 patients with inflammatory arthritis were administered a standardised questionnaire. Data collected included age, diagnosis, vaccination history, history of varicella, treatment and the presence of other indications for vaccination. 58 patients (58%) had not received the influenza vaccine in the past year. Only 19 patients (19%) had ever received pneumococcal vaccine. Anti TNF use did not predict vaccination (p = .46). An increasing number of co morbid conditions predicted both pneumococcal (p < 0.003) and influenza vaccine (p < 0.03) administration. Nineteen patients (19%) gave no history of varicella infection, none having had varicella titres checked pre treatment. Immunisation rates in patients with inflammatory arthritis on immunosuppressive therapies are low. Immunisation schedules should be available for each patient during rheumatology and general practice consultations.

  3. Lower risk of atopic disorders in whole cell pertussis-vaccinated children

    OpenAIRE

    Bernsen, Roos; Jongste, Johan; Wouden, Hans

    2003-01-01

    textabstractThis study addressed whether whole cell pertussis-vaccinated children have a different risk of atopic disorders compared with children who did not receive this vaccination. Data on vaccination status, atopic disorders and child and family characteristics of the children of 700 families were collected in this retrospective study. A minority of these 700 families refused vaccinations for religious reasons. The relation between pertussis-vaccination status and atopic disorders was an...

  4. Status of research and development of vaccines for enterovirus 71.

    Science.gov (United States)

    Reed, Zarifah; Cardosa, Mary Jane

    2016-06-01

    Although outbreaks of Hand, Foot, and Mouth Disease (HFMD) in young children have long been recognized worldwide, the occurrence of rare and life-threatening neurological, respiratory, and cardiac complications has propelled this common condition into the spotlight as a major public health problem in the affected countries. Various enteroviruses cause HFMD, but the severe complications have been mostly associated with enterovirus 71 (EV71). Medical treatment is supportive and measures to interrupt transmission have been challenging to implement. Preventive vaccines could have an important clinical impact, especially among children younger than 3 years old who are most susceptible to the neurological complications. Several groups in the highly affected Asia-Pacific region are working towards vaccines against EV71 and some candidates have progressed to late-stage clinical trials with two vaccines recently reported to have been approved by the regulatory authorities in China. This report summarizes current issues and progress in the development of vaccines against EV71. PMID:26973065

  5. Current status of vaccine development for tularemia preparedness

    OpenAIRE

    Hong, Kee-Jong; Park, Pil-Gu; Seo, Sang-Hwan; Rhie, Gi-eun; Hwang, Kyuh-Jam

    2013-01-01

    Tularemia is a high-risk infectious disease caused by Gram-negative bacterium Francisella tularensis. Due to its high fatality at very low colony-forming units (less than 10), F. tularensis is considered as a powerful potential bioterrorism agent. Vaccine could be the most efficient way to prevent the citizen from infection of F. tularensis when the bioterrorism happens, but officially approved vaccine with both efficacy and safety is not developed yet. Research for the development of tularem...

  6. Language learning, socioeconomic status, and child-directed speech.

    Science.gov (United States)

    Schwab, Jessica F; Lew-Williams, Casey

    2016-07-01

    Young children's language experiences and language outcomes are highly variable. Research in recent decades has focused on understanding the extent to which family socioeconomic status (SES) relates to parents' language input to their children and, subsequently, children's language learning. Here, we first review research demonstrating differences in the quantity and quality of language that children hear across low-, mid-, and high-SES groups, but also-and perhaps more importantly-research showing that differences in input and learning also exist within SES groups. Second, in order to better understand the defining features of 'high-quality' input, we highlight findings from laboratory studies examining specific characteristics of the sounds, words, sentences, and social contexts of child-directed speech (CDS) that influence children's learning. Finally, after narrowing in on these particular features of CDS, we broaden our discussion by considering family and community factors that may constrain parents' ability to participate in high-quality interactions with their young children. A unification of research on SES and CDS will facilitate a more complete understanding of the specific means by which input shapes learning, as well as generate ideas for crafting policies and programs designed to promote children's language outcomes. WIREs Cogn Sci 2016, 7:264-275. doi: 10.1002/wcs.1393 For further resources related to this article, please visit the WIREs website. PMID:27196418

  7. Exposure to partner violence and child behavior problems: a prospective study controlling for child physical abuse and neglect, child cognitive ability, socioeconomic status, and life stress.

    Science.gov (United States)

    Yates, Tuppett M; Dodds, Michele F; Sroufe, L Alan; Egeland, Byron

    2003-01-01

    Previous research suggests an association between partner violence and child behavior problems. However, methodological shortcomings have precluded the formation of directional conclusions. These limitations include failure to control for the effects of child physical abuse and general life stress, employment of nonrepresentative samples from battered women's shelters, and reliance on a single contemporaneous reporter, usually the mother, for information on both independent and dependent measures. This study used prospective, longitudinal data (N = 155) and multiple informants to examine the relation between maternal reports of partner violence in the homeand teacher- and youth-report ratings of concurrent and prospective child behavior problems. Hierarchical multiple regression analyses were used to control for the effects of child physical abuse, child physical neglect, socioeconomic status, child cognitive ability, and life stress. The contribution of partner violence to child behavior problems was confirmed for boys' (n = 81) externalizing problems and girls' (n = 74) internalizing problems. Child developmental status at the time of exposure further influenced these relations. For boys, behavior problems in middle childhood were most strongly related to contemporaneous partner violence, whereas behavior problems among both boys and girls at age 16 were most strongly related to partner violence exposure during the preschool years. PMID:12848442

  8. Status of vaccine research and development for Campylobacter jejuni.

    Science.gov (United States)

    Riddle, Mark S; Guerry, Patricia

    2016-06-01

    Campylobacter jejuni is one of the leading causes of bacterial diarrhea worldwide and is associated with a number of sequelae, including Guillain-Barre Syndrome, reactive arthritis, irritable bowel syndrome and growth stunting/malnutrition. Vaccine development against C. jejuni is complicated by its antigenic diversity, a lack of small animal models, and a poor understanding of the bacterium's pathogenesis. Vaccine approaches have been limited to recombinant proteins, none of which have advanced beyond Phase I testing. Genomic analyses have revealed the presence of a polysaccharide capsule on C. jejuni. Given the success of capsule-conjugate vaccines for other mucosal pathogens of global importance, efforts to evaluate this established approach for C. jejuni are also being pursued. A prototypical capsule-conjugate vaccine has demonstrated efficacy against diarrheal disease in non-human primates and is currently in Phase I testing. In addition to proof of concept studies, more data on the global prevalence of capsular types, and a better understanding of the acute and chronic consequences of C. jejuni are needed to inform investments for a globally relevant vaccine. PMID:26973064

  9. HPV and Cervical Cancer Epidemiology - Current Status of HPV Vaccination in India.

    Science.gov (United States)

    Chatterjee, Sharmila; Chattopadhyay, Amit; Samanta, Luna; Panigrahi, Pinaki

    2016-01-01

    Cervical cancer (CaCx) is the second most fatal cancer contributing to 14% of cancers in Indian females, which account for 25.4% and 26.5% of the global burden of CaCx prevalence and mortality, respectively. Persistent infection with high-risk human papilloma virus (HPV- strains 16 and 18) is the most important risk factor for precursors of invasive CaCx. Comprehensive prevention strategies for CaCx should include screening and HPV vaccination. Three screening modalities for CaCx are cytology, visual inspection with acetic acid, and HPV testing. There is no Indian national policy on CaCx prevention, and screening of asymptomatic females against CaCx is practically non-existent. HPV vaccines can make a major breakthrough in the control of CaCx in India which has high disease load and no organized screening program. Despite the Indian Government's effort to introduce HPV vaccination in the National Immunization Program and bring down vaccine cost, challenges to implementing vaccination in India are strong such as: inadequate epidemiological evidence for disease prioritization, duration of vaccine use, parental attitudes, and vaccine acceptance. This paper reviews the current epidemiology of CaCx and HPV in India, and the current status of HPV vaccination in the country. This article stresses the need for more research in the Indian context, to evaluate interventions for CaCx and assess their applicability, success, scalability and sustainability within the constraints of the Indian health care system. PMID:27644600

  10. Childhood Overweight/Obesity and Pediatric Asthma: The Role of Parental Perception of Child Weight Status

    OpenAIRE

    the STRONG Kids Research Team; Paige, Katie N.; Margarita Teran-Garcia; Donovan, Sharon M.; Salma M. A. Musaad; Fiese, Barbara H.

    2013-01-01

    Childhood obesity and asthma are on the rise in the U.S. Clinical and epidemiological data suggest a link between the two, in which overweight and obese children are at higher risk for asthma. Prevention of childhood obesity is preferred over treatment, however, in order to be receptive to messages, parents must perceive that their child is overweight. Many parents do not accurately assess their child’s weight status. Herein, the relation between parental perceptions of child weight status, o...

  11. HIV vaccines: current status worldwide and in Africa.

    Science.gov (United States)

    Fast, Patricia E; Kaleebu, Pontiano

    2010-10-01

    Since HIV-1 was identified, development of a preventive vaccine has been a major goal. Significant progress toward that goal has been made by 2010. In macaques, a vigorous T effector cell response has protected some animals from disease caused by simian immunodeficiency virus (SIV). Broadly, neutralizing human anti-HIV antibodies have been isolated and their structures, and targets are rapidly being elucidated. For the first time an AIDS vaccine has shown modest protective efficacy in a human clinical trial. To reach the final goal, there is a need for a coordinated global effort, including a range of approaches including novel high-throughput screening techniques, X-ray crystallography, and monoclonal antibody isolation, analysis of T cell responses and their impact on disease progression, human epidemiology, as well as targeted studies in nonhuman primates. African research teams as well as cohorts of healthy volunteers and HIV-infected individuals have contributed to HIV vaccine research and development in many important ways. It is essential that this work continue to speed the development and deployment of a vaccine suitable for African populations.

  12. Effect of 25-Hydroxyvitamin D Status on Serological Response to Influenza Vaccine in Prostate Cancer Patients

    Science.gov (United States)

    Chadha, Manpreet K.; Fakih, Marwan; Muindi, Josephia; Tian, Lili; Mashtare, Terry; Johnson, Candace S.; Trump, Donald

    2015-01-01

    BACKGROUND Epidemiologic data suggest that there is an association between vitamin D deficiency and influenza infection. We conducted a prospective influenza vaccination study to determine the influence of vitamin D status on serological response to influenza vaccine in prostate cancer (CaP) patients. METHODS During the 2006–2007 influenza season, CaP patients treated at Roswell Park Cancer Institute were offered vaccination with the trivalent influenza vaccine (Fluzone®, 2006–2007) and sera collected for hemagglutination inhibition (HI) assay titers before and 3 months after vaccination. Response to vaccination was defined as ≥1:40 titer ratio or a fourfold increase in titer at 3 months, against any of the three strains. Serum 25-hydroxyvitamin D (25-D3) levels were measured using DiaSorin 125I radioimmunoassay kits. RESULTS Thirty-five patients with CaP participated in the study. Median baseline 25-D3 level was 44.88 ng/ml (range: 9.16–71.98 ng/ml) Serological response against any of the three strains was noted in 80%. There was a significant effect of baseline 25-D3 level when tested as a continuous variable in relation to serological response (P = 0.0446). All patients in the upper quartile of 25-D3 level responded by mounting a serological response (P = 0.0344). None of the other baseline variables (age, race, chemotherapy status, or white cell count) had an effect on serological response. CONCLUSIONS In this study in CaP patients, a replete vitamin D status was associated with more frequent serological response to influenza vaccine. PMID:20812224

  13. Poliomyelitis vaccination status among children in the Federal Territory of Kuala Lumpur 2007

    Directory of Open Access Journals (Sweden)

    AM Haliza

    2011-07-01

    Full Text Available Introduction: Polio vaccination rates remain low in certain regions of Malaysia. The Federal Territory of Kuala Lumpur (FTKL reported coverage of only 29.3% in 2005 and 61.2% in 2006, despite a Department of Health campaign to provide free three-round immunizations. The estimated numbers of live births used to calculate these rates may have artificially lowered the reported coverage percentages.Methods: A descriptive, cross-sectional household survey was conducted throughout the FTKL in 2007 to assess the actual polio vaccination status of children aged 9 to 24 months. Minimum sample size was calculated and proportionately divided among the 11 FTKL parliamentary constituencies. Residential areas were then randomly selected for in-person interviews. We used the gathered information, verified by medical records, to calculate the actual vaccination coverage and to compare the rates determined by using estimated or registered live births for the region.Results: Of the 1713 study participants, 98.3% had completed their polio vaccination schedule. Only 21 children had been partially vaccinated, and nine children were completely unvaccinated. FTKL residents had 20 431 live births registered for 2006, as opposed to the official estimate of 28 400. When the registered value of live births was used to calculate vaccination coverage, the 2006 coverage increased (to 85.1%.Conclusion: Actual vaccination coverage in Kuala Lumpur was much higher than the estimated coverage previously reported, reflecting the expected success of the Department of Health immunization campaign. Estimated values of live births are insufficient to accurately determine vaccine status and should be avoided.

  14. Nontyphoidal salmonella disease: Current status of vaccine research and development.

    Science.gov (United States)

    Tennant, Sharon M; MacLennan, Calman A; Simon, Raphael; Martin, Laura B; Khan, M Imran

    2016-06-01

    Among more than 2500 nontyphoidal Salmonella enterica (NTS) serovars, S. enterica serovar Typhimurium and S. enterica serovar Enteritidis account for approximately fifty percent of all human isolates of NTS reported globally. The global incidence of NTS gastroenteritis in 2010 was estimated to be 93 million cases, approximately 80 million of which were contracted via food-borne transmission. It is estimated that 155,000 deaths resulted from NTS in 2010. NTS also causes severe, extra-intestinal, invasive bacteremia, referred to as invasive nontyphoidal Salmonella (iNTS) disease. iNTS disease usually presents as a febrile illness, frequently without gastrointestinal symptoms, in both adults and children. Symptoms of iNTS are similar to malaria, often including fever (>90%) and splenomegaly (>40%). The underlying reasons for the high rates of iNTS disease in Africa are still being elucidated. Evidence from animal and human studies supports the feasibility of developing a safe and effective vaccine against iNTS. Both antibodies and complement can kill Salmonella species in vitro. Proof-of-principle studies in animal models have demonstrated efficacy for live attenuated and subunit vaccines that target the O-antigens, flagellin proteins, and other outer membrane proteins of serovars Typhimurium and Enteritidis. More recently, a novel delivery strategy for NTS vaccines has been developed: the Generalized Modules for Membrane Antigens (GMMA) technology which presents surface polysaccharides and outer membrane proteins in their native conformation. GMMA technology is self-adjuvanting, as it delivers multiple pathogen-associated molecular pattern molecules. GMMA may be particularly relevant for low- and middle-income countries as it has the potential for high immunologic potency at a low cost and involves a relatively simple production process without the need for complex conjugation. Several vaccines for the predominant NTS serovars Typhimurium and Enteritidis, are

  15. Nontyphoidal salmonella disease: Current status of vaccine research and development.

    Science.gov (United States)

    Tennant, Sharon M; MacLennan, Calman A; Simon, Raphael; Martin, Laura B; Khan, M Imran

    2016-06-01

    Among more than 2500 nontyphoidal Salmonella enterica (NTS) serovars, S. enterica serovar Typhimurium and S. enterica serovar Enteritidis account for approximately fifty percent of all human isolates of NTS reported globally. The global incidence of NTS gastroenteritis in 2010 was estimated to be 93 million cases, approximately 80 million of which were contracted via food-borne transmission. It is estimated that 155,000 deaths resulted from NTS in 2010. NTS also causes severe, extra-intestinal, invasive bacteremia, referred to as invasive nontyphoidal Salmonella (iNTS) disease. iNTS disease usually presents as a febrile illness, frequently without gastrointestinal symptoms, in both adults and children. Symptoms of iNTS are similar to malaria, often including fever (>90%) and splenomegaly (>40%). The underlying reasons for the high rates of iNTS disease in Africa are still being elucidated. Evidence from animal and human studies supports the feasibility of developing a safe and effective vaccine against iNTS. Both antibodies and complement can kill Salmonella species in vitro. Proof-of-principle studies in animal models have demonstrated efficacy for live attenuated and subunit vaccines that target the O-antigens, flagellin proteins, and other outer membrane proteins of serovars Typhimurium and Enteritidis. More recently, a novel delivery strategy for NTS vaccines has been developed: the Generalized Modules for Membrane Antigens (GMMA) technology which presents surface polysaccharides and outer membrane proteins in their native conformation. GMMA technology is self-adjuvanting, as it delivers multiple pathogen-associated molecular pattern molecules. GMMA may be particularly relevant for low- and middle-income countries as it has the potential for high immunologic potency at a low cost and involves a relatively simple production process without the need for complex conjugation. Several vaccines for the predominant NTS serovars Typhimurium and Enteritidis, are

  16. The Impact of Hepatitis B Vaccination Status on the Risk of Diabetes, Implicating Diabetes Risk Reduction by Successful Vaccination

    OpenAIRE

    Jean Huang; Horng-Yih Ou; James Lin; Rudruidee Karnchanasorn; Wei Feng; Raynald Samoa; Lee-Ming Chuang; Chiu, Ken C

    2015-01-01

    Background The liver plays a key role in fuel metabolism. It is well established that liver disease is associated with an increased risk for diabetes mellitus. Hepatitis C virus infection has been known to increase the risk of diabetes. However, much less is known about the role of hepatitis B virus (HBV) infection in diabetes. We examined the association of diabetes based on the vaccination status for HBV. Methods In this cross-sectional study, we included adult subjects (≥20 y/o) with HBV s...

  17. Vaccinations

    Science.gov (United States)

    ... vaccinated? For many years, a set of annual vaccinations was considered normal and necessary for dogs and ... to protect for a full year. Consequently, one vaccination schedule will not work well for all pets. ...

  18. Child Immunization Status among a Sample of Adolescent Mothers: Comparing the Validity of Measurement Strategies

    Science.gov (United States)

    Phillips, Clarissa; Cota-Robles, Sonia; Knight, Margaret; Francis, Judith; Phillips, Elizabeth; Mazerbo, Laurie

    2011-01-01

    This study of adolescent mothers sought to identify whether a single general question asked by phone or a detailed, vaccine-specific question asked in a self-report questionnaire best captured infant immunization status at 6 months postpartum, by comparing them with immunization record books. Responses to a global question about whether infants…

  19. Child representations of disease according to age, educational level and socioeconomic status

    OpenAIRE

    Ma. Lourdes Ruda Santolaria

    2009-01-01

    The study explores child representations on the identity and origin of disease according to age, educational level and socioeconomic status. Ninety children were assessed using the Child Disease Representations Interview (CDRI) inspired in seven cards graphically repre­senting the usual treatment of children with cancer. Results show that the same element of reality can be conceptualized in multiple ways and that smaller children tend to appeal to non-serious diseases whereas older children r...

  20. Maternal encouragement and discouragement: Differences by food type and child weight status.

    Science.gov (United States)

    Pesch, Megan H; Appugliese, Danielle P; Kaciroti, Niko; Rosenblum, Katherine L; Miller, Alison L; Lumeng, Julie C

    2016-06-01

    Childhood obesity prevention practice guidelines recommend that parents encourage the intake of certain types of foods and discourage the intake of others. It is unknown if parents of children of different weight statuses encourage or discourage their child's intake differently based on food type. The objective of this study was to determine the association of child weight status with maternal encouragement and discouragement of for four different types of food. A total of 222 mother-child dyads were video-taped during the standardized, sequential presentation of four foods to both participants: cupcakes (familiar dessert), green beans (familiar vegetable), halva (unfamiliar dessert) and artichoke (unfamiliar vegetable). Mother's encouragements and discouragements of child intake were reliably coded for each food type. Poisson regression models were used to test the independent association of child weight status (normal weight, overweight and obese) with encouragement and discouragement for each food type. Mothers of an obese, vs. normal or overweight child, had lower rates of encouragement for a familiar dessert (p = 0.02), and a higher rates of discouragements for a familiar dessert (p = 0.001), a familiar vegetable (p = 0.01), and an unfamiliar vegetable (p = 0.001). There were no differences in encouragements or discouragements between mothers of an overweight, vs. obese child, for any of the 4 food types. Mothers of obese children may alter their feeding behavior differentially based on food type. Future work should examine how interventions promoting maternal encouragement or discouragement of different food types impact child weight status. PMID:26924561

  1. Parent-child resemblance in weight status and its correlates in the United States.

    Directory of Open Access Journals (Sweden)

    Yinghui Liu

    Full Text Available BACKGROUND: Few studies have examined parent-child resemblance in body weight status using nationally representative data for the US. DESIGN: We analyzed Body Mass Index (BMI, weight status, and related correlates for 4,846 boys, 4,725 girls, and their parents based on US nationally representative data from the 2006 and 2007 Medical Expenditure Panel Survey (MEPS. Pearson partial correlation coefficients, percent agreement, weighted kappa coefficients, and binary and multinomial logistic regression were used to examine parent-child resemblance, adjusted for complex sampling design. RESULTS: Pearson partial correlation coefficients between parent and child's BMI measures were 0.15 for father-son pairs, 0.17 for father-daughter pairs, 0.20 for mother-son pairs, and 0.23 for mother-daughter pairs. The weighted kappa coefficients between BMI quintiles of parent and child ranged from -0.02 to 0.25. Odds ratio analyses found children were 2.1 (95% confidence interval (CI: 1.6, 2.8 times more likely to be obese if only their father was obese, 1.9 (95% CI: 1.5, 2.4 times more likely if only their mother was obese, and 3.2 (95% CI: 2.5, 4.2 times more likely if both parents were obese. CONCLUSIONS: Parent-child resemblance in BMI appears weak and may vary across parent-child dyad types in the US population. However, parental obesity status is associated with children's obesity status. Use of different measures of parent-child resemblance in body weight status can lead to different conclusions.

  2. Childhood overweight/obesity and pediatric asthma: the role of parental perception of child weight status.

    Science.gov (United States)

    Musaad, Salma M A; Paige, Katie N; Teran-Garcia, Margarita; Donovan, Sharon M; Fiese, Barbara H; The Strong Kids Research Team

    2013-09-23

    Childhood obesity and asthma are on the rise in the U.S. Clinical and epidemiological data suggest a link between the two, in which overweight and obese children are at higher risk for asthma. Prevention of childhood obesity is preferred over treatment, however, in order to be receptive to messages, parents must perceive that their child is overweight. Many parents do not accurately assess their child's weight status. Herein, the relation between parental perceptions of child weight status, observed body mass index (BMI) percentiles, and a measure of child feeding practices were explored in the context of asthma, food allergy, or both. Out of the children with asthma or food allergy that were classified as overweight/obese by BMI percentiles, 93% were not perceived as overweight/obese by the parent. Mean scores for concern about child weight were higher in children with both asthma and food allergy than either condition alone, yet there were no significant differences among the groups in terms of pressure to eat and restrictive feeding practices. In summary, parents of children with asthma or food allergy were less likely to recognize their child's overweight/obese status and their feeding practices did not differ from those without asthma and food allergy.

  3. Maternal education is associated with vaccination status of infants less than 6 months in Eastern Uganda: a cohort study

    OpenAIRE

    Tumwine James K; Tylleskär Thorkild; Nankabirwa Victoria; Sommerfelt Halvor

    2010-01-01

    Abstract Background Despite provision of free childhood vaccinations, less than half of all Ugandan infants are fully vaccinated. This study compares women with some secondary schooling to those with only primary schooling with regard to their infants' vaccination status. Methods A community-based prospective cohort study conducted between January 2006 and May 2008 in which 696 pregnant women were followed up to 24 weeks post partum. Information was collected on the mothers' education and vac...

  4. Household and community socioeconomic and environmental determinants of child nutritional status in Cameroon

    Directory of Open Access Journals (Sweden)

    Pongou Roland

    2006-04-01

    Full Text Available Abstract Background Undernutrition is a leading cause of child mortality in developing countries, especially in sub-Saharan Africa. We examine the household and community level socioeconomic and environmental factors associated with child nutritional status in Cameroon, and changes in the effects of these factors during the 1990s economic crisis. We further consider age-specific effects of household economic status on child nutrition. Methods Child nutritional status was measured by weight-for-age (WAZ and height-for-age (HAZ z-scores. Data were from Demographic and Health Surveys conducted in 1991 and 1998. We used analysis of variance to assess the bivariate association between the explanatory factors and nutritional status. Multivariate, multilevel analyses were undertaken to estimate the net effects of both household and community factors. Results Average WAZ and HAZ declined respectively from -0.70 standard deviations (SD, i.e. 0.70 SD below the reference median, to -0.83 SD (p = 0.006 and from -1.03 SD to -1.14 SD (p = 0.026 between 1991 and 1998. These declines occurred mostly among boys, children over 12 months of age, and those of low socioeconomic status. Maternal education and maternal health seeking behavior were associated with better child nutrition. Household economic status had an overall positive effect that increased during the crisis, but it had little effect in children under 6 months of age. Improved household (water, sanitation and cooking fuel and community environment had positive effects. Children living in the driest regions of the country were consistently worst off, and those in the largest cities were best off. Conclusion Both household and community factors have significant impact on child health in Cameroon. Understanding these relationships can facilitate design of age- and community-specific intervention programs.

  5. Factors associated with parental recognition of a child's overweight status - a cross sectional study

    Directory of Open Access Journals (Sweden)

    Kaikkonen Kaisu M

    2011-08-01

    Full Text Available Abstract Background Very few studies have evaluated the association between a child's lifestyle factors and their parent's ability to recognise the overweight status of their offspring. The aim of this study was to analyze the factors associated with a parent's ability to recognise their own offspring's overweight status. Methods 125 overweight children out of all 1,278 school beginners in Northern Finland were enrolled. Weight and height were measured in health care clinics. Overweight status was defined by BMI according to internationally accepted criteria. A questionnaire to be filled in by parents was delivered by the school nurses. The parents were asked to evaluate their offspring's weight status. The child's eating habits and physical activity patterns were also enquired about. Factor groups of food and physical activity habits were formed by factor analysis. Binary logistic regression was performed using all variables associated with recognition of overweight status in univariate analyses. The significant risk factors in the final model are reported using odds ratios (ORs and their 95% confidence intervals (CIs. Results Fifty-seven percent (69/120 of the parents of the overweight children considered their child as normal weight. Child's BMI was positively associated with parental recognition of overweight (OR 3.59, CI 1.8 to 7.0. Overweight boys were less likely to be recognised than overweight girls (OR 0.14, CI 0.033 to 0.58. Child's healthy diet (OR 0.22, CI 0.091 to 0.54 and high physical activity (OR 0.29, CI 0.11 to 0.79 were inversely related to parental recognition of overweight status. Conclusions Child's healthy eating habits and physical activity are inversely related to parental recognition of their offspring's overweight. These should be taken into account when planning prevention and treatment strategies for childhood obesity.

  6. Paternal investment and status-related child outcomes: timing of father's death affects offspring success.

    Science.gov (United States)

    Shenk, Mary K; Scelza, Brooke A

    2012-09-01

    Recent work in human behavioural ecology has suggested that analyses focusing on early childhood may underestimate the importance of paternal investment to child outcomes since such investment may not become crucial until adolescence or beyond. This may be especially important in societies with a heritable component to status, as later investment by fathers may be more strongly related to a child's adult status than early forms of parental investment that affect child survival and child health. In such circumstances, the death or absence of a father may have profoundly negative effects on the adult outcomes of his children that cannot be easily compensated for by the investment of mothers or other relatives. This proposition is tested using a multigenerational dataset from Bangalore, India, containing information on paternal mortality as well as several child outcomes dependent on parental investment during adolescence and young adulthood. The paper examines the effects of paternal death, and the timing of paternal death, on a child's education, adult income, age at marriage and the amount spent on his or her marriage, along with similar characteristics of spouses. Results indicate that a father's death has a negative impact on child outcomes, and that, in contrast to some findings in the literature on father absence, the effects of paternal death are strongest for children who lose their father in late childhood or adolescence.

  7. Vaccination Confidence and Parental Refusal/Delay of Early Childhood Vaccines

    Science.gov (United States)

    Gilkey, Melissa B.; McRee, Annie-Laurie; Magnus, Brooke E.; Reiter, Paul L.; Dempsey, Amanda F.; Brewer, Noel T.

    2016-01-01

    Objective To support efforts to address parental hesitancy towards early childhood vaccination, we sought to validate the Vaccination Confidence Scale using data from a large, population-based sample of U.S. parents. Methods We used weighted data from 9,354 parents who completed the 2011 National Immunization Survey. Parents reported on the immunization history of a 19- to 35-month-old child in their households. Healthcare providers then verified children’s vaccination status for vaccines including measles, mumps, and rubella (MMR), varicella, and seasonal flu. We used separate multivariable logistic regression models to assess associations between parents’ mean scores on the 8-item Vaccination Confidence Scale and vaccine refusal, vaccine delay, and vaccination status. Results A substantial minority of parents reported a history of vaccine refusal (15%) or delay (27%). Vaccination confidence was negatively associated with refusal of any vaccine (odds ratio [OR] = 0.58, 95% confidence interval [CI], 0.54–0.63) as well as refusal of MMR, varicella, and flu vaccines specifically. Negative associations between vaccination confidence and measures of vaccine delay were more moderate, including delay of any vaccine (OR = 0.81, 95% CI, 0.76–0.86). Vaccination confidence was positively associated with having received vaccines, including MMR (OR = 1.53, 95% CI, 1.40–1.68), varicella (OR = 1.54, 95% CI, 1.42–1.66), and flu vaccines (OR = 1.32, 95% CI, 1.23–1.42). Conclusions Vaccination confidence was consistently associated with early childhood vaccination behavior across multiple vaccine types. Our findings support expanding the application of the Vaccination Confidence Scale to measure vaccination beliefs among parents of young children. PMID:27391098

  8. Vaccination Confidence and Parental Refusal/Delay of Early Childhood Vaccines.

    Directory of Open Access Journals (Sweden)

    Melissa B Gilkey

    Full Text Available To support efforts to address parental hesitancy towards early childhood vaccination, we sought to validate the Vaccination Confidence Scale using data from a large, population-based sample of U.S. parents.We used weighted data from 9,354 parents who completed the 2011 National Immunization Survey. Parents reported on the immunization history of a 19- to 35-month-old child in their households. Healthcare providers then verified children's vaccination status for vaccines including measles, mumps, and rubella (MMR, varicella, and seasonal flu. We used separate multivariable logistic regression models to assess associations between parents' mean scores on the 8-item Vaccination Confidence Scale and vaccine refusal, vaccine delay, and vaccination status.A substantial minority of parents reported a history of vaccine refusal (15% or delay (27%. Vaccination confidence was negatively associated with refusal of any vaccine (odds ratio [OR] = 0.58, 95% confidence interval [CI], 0.54-0.63 as well as refusal of MMR, varicella, and flu vaccines specifically. Negative associations between vaccination confidence and measures of vaccine delay were more moderate, including delay of any vaccine (OR = 0.81, 95% CI, 0.76-0.86. Vaccination confidence was positively associated with having received vaccines, including MMR (OR = 1.53, 95% CI, 1.40-1.68, varicella (OR = 1.54, 95% CI, 1.42-1.66, and flu vaccines (OR = 1.32, 95% CI, 1.23-1.42.Vaccination confidence was consistently associated with early childhood vaccination behavior across multiple vaccine types. Our findings support expanding the application of the Vaccination Confidence Scale to measure vaccination beliefs among parents of young children.

  9. [Influence of child nutrition on health status during adult years].

    Science.gov (United States)

    Ksiazyk, J

    2000-01-01

    The problem of safety of child's nutrition should be considered from the moment of his conception because intrauterine growth may be related to the diseases in adult life: atherosclerosis and coronary heart disease. Strict vegetarian diets are not appropriate for children. The task of proper nutrition in childhood is to prevent adult life diseases and to promote potentially highest quality of life and development of cognitive and intellectual functions, and proper growth. The role of microelements - iron and zinc - is also discussed.

  10. Lower risk of atopic disorders in whole cell pertussis-vaccinated children

    NARCIS (Netherlands)

    R.M.D. Bernsen (Roos); J.C. de Jongste (Johan); J.C. van der Wouden (Hans)

    2003-01-01

    textabstractThis study addressed whether whole cell pertussis-vaccinated children have a different risk of atopic disorders compared with children who did not receive this vaccination. Data on vaccination status, atopic disorders and child and family characteristics of the children

  11. Multiple Family Groups to reduce child disruptive behavior difficulties: moderating effects of child welfare status on child outcomes.

    Science.gov (United States)

    Gopalan, Geetha; Small, Latoya; Fuss, Ashley; Bowman, Melissa; Jackson, Jerrold; Marcus, Sue; Chacko, Anil

    2015-08-01

    Children who remain at home with their permanent caregivers following a child welfare (CW) involvement (e.g., investigation, out-of-home placement) manifest high rates of behavioral difficulties, which is a risk factor for further maltreatment and out-of-home placement if not treated effectively. A recently tested Multiple Family Group (MFG) service delivery model to treat youth Disruptive Behavior Disorders (DBDs) has demonstrated effectiveness in improving child behavior difficulties among hard-to-engage, socioeconomically disadvantaged families by addressing parenting skills, parent-child relationships, family communication and organization, social support, and stress. This exploratory study examines whether child behavioral outcomes for MFG differ for families with self-reported lifetime involvement in CW services compared to other families, as families with CW involvement struggle with additional stressors that can diminish treatment success. Youth (aged 7-11) and their families were assigned to MFG or services as usual (SAU) using a block comparison design. Caregivers reported on child behavior, social skills, and functional impairment. Mixed effects regression modeled multilevel outcomes across 4 assessment points (i.e., baseline, mid-test, post-test, 6-month follow-up). Among CW-involved families, MFG participants reported significantly reduced child oppositional defiant disorder symptoms at 6-month follow-up compared with SAU participants. No other differences were found in the effect of MFG treatment between CW and non-CW involved families. Findings suggest that MFG may be as effective in reducing child behavior difficulties for both CW and non-CW involved families. As a short-term, engaging, and efficient intervention, MFG may be a particularly salient service offering for families involved in the CW system. PMID:26188424

  12. How does parents' visual perception of their child's weight status affect their feeding style?

    OpenAIRE

    Resul Yilmaz; Ünal Erkorkmaz; Mustafa Ozcetin; Erhan Karaaslan

    2013-01-01

    Introduction: Eating style is one of the prominent factors that determine energy intake. One of the influencing factors that determine parental feeding style is parental perception of the weight status of the child. Aim: The aim of this study is to evaluate the relationship between maternal visual perception of their children's weight status and their feeding style. Method: A cross-sectional survey was completed with only mother's of 380 preschool children with age of 5 to 7 (6.14 years). Vis...

  13. Predicting Infant Maltreatment in Low-Income Families: The Interactive Effects of Maternal Attributions and Child Status at Birth

    Science.gov (United States)

    Bugental, Daphne Blunt; Happaney, Keith

    2004-01-01

    Maternal attributions and child neonatal status at birth were assessed as predictors of infant maltreatment (harsh parenting and safety neglect). The population included low-income, low-education families who were primarily Hispanic. Child maltreatment during the 1st year of life (N = 73) was predicted by neonatal status (low Apgar scores, preterm…

  14. Reasons for non-adherence to vaccination at mother and child care clinics (MCCs) in Lambaréné, Gabon

    NARCIS (Netherlands)

    N.G. Schwarz; M. Gysels; C. Pell; J. Gabor; M. Schlie; S. Issifou; B. Lell; P.G. Kremsner; M.P. Grobusch; R. Pool

    2009-01-01

    The aim of this paper is to explore attitudes of mothers towards childhood vaccinations and reasons for non-attendance and non-adherence to mother-child clinics (MCCs). Forty in-depth interviews with mothers of children under 5 years of age revealed positive attitudes towards vaccination that seem a

  15. Hepatitis B vaccination status among healthcare workers in a tertiary care hospital in Haldwani City of Nainital, Uttarakhand, India

    Directory of Open Access Journals (Sweden)

    Subhash Chandra Joshi

    2014-01-01

    Full Text Available Background: Healthcare workers (HCWs have a high risk of hepatitis B virus (HBV infection. The prevalence of HBV among HCWs in hospitals in developing countries is high. However, the vaccination status of these workers in hospitals in Haldwani city is not well documented. Objectives: The aim was to assess the hepatitis B vaccination status among HCWs in a tertiary care hospital in Haldwani city of Nainital, Uttarakhand, India. Materials and Methods: In this cross-sectional study, 367 HCWs were randomly selected. Information pertaining to demographic and vaccination status was collected by interviewing them with the help of predesigned and pretested interview schedule. Result: The overall proportions of complete, incomplete and unvaccinated respondents with hepatitis B vaccine were 48.5%, 21.8%, and 29.7% respectively. In relation to designation of respondents, 35 (53.8%, 65 (77.4%, 61 (51.7%, 12 (40.0% and 5 (7.2% of respondents who were residents, interns, nurses, technicians and nursing attendants respectively had received Hepatitis B vaccination as against those who had partially received and not received vaccination and this differences were statistically significant. The most common reason for acceptance of vaccine was protection against Hepatitis-B infection (39.9% and the commonest reason for not getting vaccinated was negligence (43.1% Conclusion: These results conclude that because of low immunization coverage, HCWs are at greater risk of getting Hepatitis B infection at the hospital.

  16. Maternal Fatty Acid Status During Pregnancy and Child Autistic Traits: The Generation R Study.

    Science.gov (United States)

    Steenweg-de Graaff, Jolien; Tiemeier, Henning; Ghassabian, Akhgar; Rijlaarsdam, Jolien; Jaddoe, Vincent W V; Verhulst, Frank C; Roza, Sabine J

    2016-05-01

    ω-3 and ω-6 polyunsaturated fatty acids are important for brain function and development. We examined whether maternal polyunsaturated fatty acid status during pregnancy affects risk of autistic traits in childhood. Within the Generation R cohort, we measured maternal plasma polyunsaturated fatty acid concentrations and the ω-3:ω-6 ratio in midpregnancy (Rotterdam, the Netherlands, 2001-2005). Child autistic traits at 6 years were assessed by using the Social Responsiveness Scale short form in 4,624 children. A lower maternal ω-3:ω-6 ratio during pregnancy was associated with more autistic traits in the offspring (β = -0.008, 95% confidence interval: -0.016, -0.001). In particular, a higher total ω-6 and linoleic acid status were associated with more autistic traits (all P's < 0.05). Associations were independent of child intelligence, suggesting that the fatty acid distribution specifically affects the development of autistic traits in addition to general neurodevelopment. Maternal plasma ω-3 status was not associated with child autistic traits and, consistently, neither was prenatal dietary fish intake. Our study shows that a lower prenatal ω-3:ω-6 ratio is associated with more child autistic traits, which is largely accounted for by higher ω-6 instead of lower ω-3 status. These results suggest a biological pathway between maternal fatty acid intake during pregnancy and autistic traits in the offspring. PMID:27052119

  17. The Status of Functional Categories in Child Second Language Acquisition: Evidence from the Acquisition of CP.

    Science.gov (United States)

    Haznedar, Belma

    2003-01-01

    Examines the status of the functional categories in child second language (L2) acquisition of English. Results from longitudinally-collected data are reported, presenting counterevidence for recent hypotheses on early L2 acquisition that assume the following: (1) structure building approach according to which the acquisition of functional…

  18. Research on the Child Development Project: Current Status and Future Directions.

    Science.gov (United States)

    Battistich, Victor; Solomon, Daniel

    1989-01-01

    Reports on the current status of the Child Development Project (San Ramon, California). States that major concerns focus upon validity of measures and criterion validity. Notes that there are indications that the program is being implemented and children's attitudes are being affected. Predicts additional teacher questionnaire measures and the…

  19. Parental Socio-Economic Status as Correlate of Child Labour in Ile-Ife, Nigeria

    Science.gov (United States)

    Elegbeleye, O. S.; Olasupo, M. O.

    2012-01-01

    This study investigated the relationship between parental socio-economic status and child labour practices in Ile-Ife, Nigeria. The study employed survey method to gather data from 200 parents which constituted the study population. Pearson Product Moment Correlation and t-test statistics were used for the data analyses. The outcome of the study…

  20. Parenting Styles, Communication and Child/Adolescent Diets and Weight Status: Let's Talk about It

    Science.gov (United States)

    Parletta, Natalie; Peters, Jacqueline; Owen, Amber; Tsiros, Margarita D.; Brennan, Leah

    2012-01-01

    Parenting styles have been associated with health-related behaviours in children and adolescents. We present a series of studies. Study 1 investigated parenting styles and parent-child communication styles as cross-sectional predictors of dietary patterns in children, and study 2 as cross-sectional predictors of weight status in adolescents. Data…

  1. Does livestock ownership affect animal source foods consumption and child nutritional status ? evidence from rural Uganda

    OpenAIRE

    Azzarri, Carlo; Cross, Elizabeth; Haile, Beliyou; Zezza, Alberto

    2014-01-01

    In many developing countries, consumption of animal source foods among the poor is still at a level where increasing its share in total caloric intake may have many positive nutritional benefits. This paper explores whether ownership of various livestock species increases consumption of animal source foods and helps improve child nutritional status. The paper finds some evidence that food ...

  2. Adult Sexual Outcomes of Child Sexual Abuse Vary According to Relationship Status.

    Science.gov (United States)

    Vaillancourt-Morel, Marie-Pier; Godbout, Natacha; Sabourin, Stéphane; Briere, John; Lussier, Yvan; Runtz, Marsha

    2016-04-01

    This study tested a moderation model in which the association between child sexual abuse severity and negative sexual outcomes (i.e., sexual avoidance and compulsivity) differed as a function of relationships status (i.e., single, cohabiting, and married individuals). A sample of 1,033 adults completed self-report questionnaires online, and 21.5% reported childhood sexual abuse. Path analyses indicated that child sexual abuse severity was associated with higher sexual compulsivity in single individuals, both higher sexual avoidance and compulsivity in cohabiting individuals, and higher sexual avoidance in married individuals. The moderation model was invariant across men and women. These results suggest that the time course of negative sexual outcomes associated with child sexual abuse may follow distinct patterns of expression according to relationship status. PMID:26804731

  3. Status report on maternal and child health indicators.

    Science.gov (United States)

    Givens, S R; Moore, M L

    1995-06-01

    The health of pregnant women and children has improved substantially since the 1960s. In the past decade, however, progress in preventing infant deaths, reducing the incidence of low-birth-weight infants, and ensuring first trimester prenatal care has slowed. African-American infants suffer a significantly higher risk of poor pregnancy outcome. Immunization rates for preschoolers remain low. Changing social conditions including a rising child poverty rate, a high teenage birth rate, an increased rate of births to unmarried women, and higher levels of unintended pregnancy may be contributing to stalled progress. PMID:7745540

  4. Assessment of hepatitis B vaccination status in doctors of Services hospital, Lahore

    International Nuclear Information System (INIS)

    Background: Hepatitis B is the most common serious infection of the liver and can lead to premature death from liver cancer or liver failure. Of the two billion people who have been infected with Hepatitis B virus, more than 350 million have chronic infection. The objectives of this study were to assess the Hepatitis B vaccination status, reasons for non-compliance and the risk of exposure to doctors at a tertiary care hospital. Methods: Three hundred and twenty-two doctors were selected from the various departments of the hospital by simple random sampling. They were given a self-administered questionnaire after taking verbal consent. Some doctors refused to fill-in the questionnaire while some others were on leave during the time of study and the remaining 215 doctors responded to the questionnaire. Results: A total of 215 doctors, (age range 22-59 years) responded to the questionnaire. Amongst them 11.6% had not received even a single dose of Hepatitis B vaccine while 14.4% had not completed the required course of vaccination. Most common reason cited by doctors for non immunisation was that they had not thought about it. Consultants were more likely of the other doctors to have received completed vaccination (83.9% versus 69.9%) (p<0.05). They were also significantly more likely to know their antibody titre after completing vaccination. Needle stick injuries were common. One hundred and forty-five doctors in the study admitted having received at least one needle prick/sharp injury. Of them, 51.6% had received a needle prick/sharp injury more than once. Conclusion: Despite the availability of an effective vaccine in the market doctors continue to remain non-vaccinated. It is the lack of awareness and carelessness on part of doctors coupled with the negligence of the risk that has led them being incompletely vaccinated. There is a need to ensure that every doctor is completely vaccinated against Hepatitis B before he/she enters professional practice. (author)

  5. Acute Disseminated Encephalomyelitis following Vaccination against Hepatitis B in a Child: A Case Report and Literature Review

    Science.gov (United States)

    Yuan, Jun-liang; Wang, Shuang-kun; Guo, Xiao-juan

    2016-01-01

    Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system, which has been associated with several vaccines such as rabies, diphtheria-tetanus-polio, smallpox, measles, mumps, rubella, Japanese B encephalitis, pertussis, influenza, and the Hog vaccine. Here, we presented a case of 12-year-old child who suffered from ADEM three weeks after hepatitis B vaccination. He was admitted to our hospital with symptoms of weakness of limbs, high fever, and alteration of consciousness. Some abnormalities were also found in CSF. Treatment with high-dose corticosteroids and intravenous immunoglobulin had significant effect, with marked improvement of the clinical symptoms and the results of CSF. The findings of MRI also detected some abnormal lesions located in both brain and spinal cord. The clinical features, the findings of CSF and MRI, and therapeutic effect may contribute to such diagnosis of ADEM. PMID:27478662

  6. Acute Disseminated Encephalomyelitis following Vaccination against Hepatitis B in a Child: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Jun-liang Yuan

    2016-01-01

    Full Text Available Acute disseminated encephalomyelitis (ADEM is an inflammatory demyelinating disease of the central nervous system, which has been associated with several vaccines such as rabies, diphtheria-tetanus-polio, smallpox, measles, mumps, rubella, Japanese B encephalitis, pertussis, influenza, and the Hog vaccine. Here, we presented a case of 12-year-old child who suffered from ADEM three weeks after hepatitis B vaccination. He was admitted to our hospital with symptoms of weakness of limbs, high fever, and alteration of consciousness. Some abnormalities were also found in CSF. Treatment with high-dose corticosteroids and intravenous immunoglobulin had significant effect, with marked improvement of the clinical symptoms and the results of CSF. The findings of MRI also detected some abnormal lesions located in both brain and spinal cord. The clinical features, the findings of CSF and MRI, and therapeutic effect may contribute to such diagnosis of ADEM.

  7. Undocumented Status: Implications for Child Development, Policy, and Ethical Research

    Science.gov (United States)

    Suárez-Orozco, Carola; Yoshikawa, Hirokazu

    2013-01-01

    Nearly 5.5 million children in the United States grow up in the shadows of undocumented status. We review the ecological domains of influence in children's and adolescents' lives and briefly consider health, cognitive, socioemotional, educational, and labor market outcomes ripe for study. We also reflect upon the ethical policy…

  8. Routine vaccination coverage in low- and middle-income countries: further arguments for accelerating support to child vaccination services

    Directory of Open Access Journals (Sweden)

    Wenjing Tao

    2013-04-01

    Full Text Available Background and objective: The Expanded Programme on Immunization was introduced by the World Health Organization (WHO in all countries during the 1970s. Currently, this effective public health intervention is still not accessible to all. This study evaluates the change in routine vaccination coverage over time based on survey data and compares it to estimations by the WHO and United Nations Children's Fund (UNICEF. Design: Data of vaccination coverage of children less than 5 years of age was extracted from Demographic and Health Surveys (DHS conducted in 71 low- and middle-income countries during 1986–2009. Overall trends for vaccination coverage of tuberculosis, diphtheria, tetanus, pertussis, polio and measles were analysed and compared to WHO and UNICEF estimates. Results: From 1986 to 2009, the annual average increase in vaccination coverage of the studied diseases ranged between 1.53 and 1.96% units according to DHS data. Vaccination coverage of diphtheria, tetanus, pertussis, polio and measles was all under 80% in 2009. Non-significant differences in coverage were found between DHS data and WHO and UNICEF estimates. Conclusions: The coverage of routine vaccinations in low- and middle-income countries may be lower than that previously reported. Hence, it is important to maintain and increase current vaccination levels.

  9. Child nutritional status in contexts of urban poverty: a reliable indicator of family health?

    Directory of Open Access Journals (Sweden)

    Juliana Huergo

    2016-03-01

    Full Text Available This work questions the premise that the nutritional status of children under six years of age is a reliable indicator of family health. To do so, a research strategy based in case studies was carried out, following a qualitative design (participant observation and semistructured interviews using intentional sampling and framed within the interpretivist paradigm. The anthropometric measurements of 20 children under six years of age attending the local Child Care Center in Villa La Tela, Córdoba were evaluated. Nutritional status was understood as an object that includes socially determined biological processes, and was therefore posited analytically as a cross between statistical data and its social determination. As a statistic, child nutritional status is merely descriptive; to assist in the understanding of its social determination, it must be placed in dialectical relationship with the spheres of sociability proposed to analyze the reproduction of health problems.

  10. Serotype 19A bacteremic pneumococcal pneumonia after 4 doses of 13-valent conjugate vaccine: a review of pneumococcal conjugate vaccine effectiveness

    OpenAIRE

    IrohTam, Pui-Ying; Hanisch, Benjamin R.; Forward, Brennan

    2014-01-01

    We report a case of bacteremic pneumococcal pneumonia due to serotype 19A in a child who had received four doses of the 13-valent pneumococcal conjugate vaccine, and review the literature on effectiveness of this vaccine. Pediatricians should be alert to the fact that up-to-date immunization status with pneumococcal vaccine does not preclude illness from invasive disease caused by a vaccine serotype.

  11. Child mortality related to seroconversion or lack of seroconversion after measles vaccination

    DEFF Research Database (Denmark)

    Aaby, Peter; Pedersen, I R; Knudsen, K;

    1989-01-01

    When blood samples were analyzed for seroconversion after measles vaccination, it was discovered that the vaccine had been ineffective for a certain period. During the 2 years between vaccination and the time of seroanalysis, nonseroconverters had a significantly higher mortality than seroconvert...

  12. Child representations of disease according to age, educational level and socioeconomic status

    Directory of Open Access Journals (Sweden)

    Ma. Lourdes Ruda Santolaria

    2009-06-01

    Full Text Available The study explores child representations on the identity and origin of disease according to age, educational level and socioeconomic status. Ninety children were assessed using the Child Disease Representations Interview (CDRI inspired in seven cards graphically repre­senting the usual treatment of children with cancer. Results show that the same element of reality can be conceptualized in multiple ways and that smaller children tend to appeal to non-serious diseases whereas older children refer to more serious ones. Children represent the disease consistently with what child development literature has depicted. Within the lower socioeconomic level, there is a delay in the access to certain concepts, which is recti­fied at later stages.

  13. Child Nutritional Status: A Representative Survey in a Metropolitan School

    Directory of Open Access Journals (Sweden)

    Paolo Rosati

    2013-01-01

    Full Text Available Objective. To assess the prevalence of obesity, overweight, and thinness among children in an Italian school. Methods. Five hundred ninety-five children (289 males and 306 females were enrolled, aged between 6 and 19 years old, in Italian school in Rome. Body mass index (BMI was calculated according to International Obesity Task Force (IOFT cut-off points. By age criterion all participants have been classified in age classes. Results. A normal BMI was recorded in 73.6% of all cases. Obesity, overweight, and thinness prevalence was 5.9%, 9.6%, and 10.9%, respectively, without statistical differences in both genders, except the prevalence of overweight that resulted statistically significant (13.1% males versus 6.2% females, . Differences in the age groups have been found. About 23.4% of children between 7 to 11 years were defined obese and about 42.3% between 6 to 8 years thin grade 2, respectively. Conclusion. The study reports the low prevalence of overweight and obesity, in contrast to the unexpected thinness prevalence. The identification of specific age groups with abnormal nutritional status could be the first step to address future epidemiological investigations in order to plan strategic approach in selected age periods.

  14. Effect of socioeconomic status on caregivers' knowledge and beliefs regarding child health care in Savelugu Nanton, Ghana

    OpenAIRE

    Hekli, Patience

    2009-01-01

    Overview: A primary caregivers’ knowledge about child health can have a significant impact on her practices, which in turn can affect child growth and development. The main objective of the study was to explore the level of caregiver’s knowledge and beliefs about the treatment of diarrhoea and child nutrition and to find out whether caregivers’ socio-economic status influences their knowledge and beliefs. Methods: In this study, the data used were from the Savelugu- Nanton Household ...

  15. The Effect of Perceived Child Anxiety Status on Parental Latency to Intervene with Anxious and Nonanxious Youth

    Science.gov (United States)

    Aschenbrand, Sasha G.; Kendall, Philip C.

    2012-01-01

    Objective: We examined the effect of perceived child anxiety status on parental latency to intervene with anxious and nonanxious youth. Method: Parents (68) of anxiety-disordered (PAD) and nonanxiety-disordered (PNAD; 56) children participated. Participants listened and responded to an audio vignette of a parent-child interaction: Half were told…

  16. Gender Determinants of Vaccination Status in Children: Evidence from a Meta-Ethnographic Systematic Review

    Science.gov (United States)

    Biaggi, Christina; Secula, Florence; Bosch-Capblanch, Xavier; Namgyal, Pem; Hombach, Joachim

    2015-01-01

    Using meta-ethnographic methods, we conducted a systematic review of qualitative research to understand gender-related reasons at individual, family, community and health facility levels why millions of children in low and middle income countries are still not reached by routine vaccination programmes. A systematic search of Medline, Embase, CINAHL, Cochrane Library, ERIC, Anthropological Lit, CSA databases, IBSS, ISI Web of Knowledge, JSTOR, Soc Index and Sociological Abstracts was conducted. Key words were built around the themes of immunization, vaccines, health services, health behaviour, and developing countries. Only papers, which reported on in-depth qualitative data, were retained. Twenty-five qualitative studies, which investigated barriers to routine immunisation, were included in the review. These studies were conducted between 1982 and 2012; eighteen were published after 2000. The studies represent a wide range of low- to middle income countries including some that have well known coverage challenges. We found that women's low social status manifests on every level as a barrier to accessing vaccinations: access to education, income, as well as autonomous decision-making about time and resource allocation were evident barriers. Indirectly, women's lower status made them vulnerable to blame and shame in case of childhood illness, partly reinforcing access problems, but partly increasing women's motivation to use every means to keep their children healthy. Yet in settings where gender discrimination exists most strongly, increasing availability and information may not be enough to reach the under immunised. Programmes must actively be designed to include mitigation measures to facilitate women's access to immunisation services if we hope to improve immunisation coverage. Gender inequality needs to be addressed on structural, community and household levels if the number of unvaccinated children is to substantially decrease. PMID:26317975

  17. Gender Determinants of Vaccination Status in Children: Evidence from a Meta-Ethnographic Systematic Review.

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    Sonja Merten

    Full Text Available Using meta-ethnographic methods, we conducted a systematic review of qualitative research to understand gender-related reasons at individual, family, community and health facility levels why millions of children in low and middle income countries are still not reached by routine vaccination programmes. A systematic search of Medline, Embase, CINAHL, Cochrane Library, ERIC, Anthropological Lit, CSA databases, IBSS, ISI Web of Knowledge, JSTOR, Soc Index and Sociological Abstracts was conducted. Key words were built around the themes of immunization, vaccines, health services, health behaviour, and developing countries. Only papers, which reported on in-depth qualitative data, were retained. Twenty-five qualitative studies, which investigated barriers to routine immunisation, were included in the review. These studies were conducted between 1982 and 2012; eighteen were published after 2000. The studies represent a wide range of low- to middle income countries including some that have well known coverage challenges. We found that women's low social status manifests on every level as a barrier to accessing vaccinations: access to education, income, as well as autonomous decision-making about time and resource allocation were evident barriers. Indirectly, women's lower status made them vulnerable to blame and shame in case of childhood illness, partly reinforcing access problems, but partly increasing women's motivation to use every means to keep their children healthy. Yet in settings where gender discrimination exists most strongly, increasing availability and information may not be enough to reach the under immunised. Programmes must actively be designed to include mitigation measures to facilitate women's access to immunisation services if we hope to improve immunisation coverage. Gender inequality needs to be addressed on structural, community and household levels if the number of unvaccinated children is to substantially decrease.

  18. Gender Determinants of Vaccination Status in Children: Evidence from a Meta-Ethnographic Systematic Review.

    Science.gov (United States)

    Merten, Sonja; Martin Hilber, Adriane; Biaggi, Christina; Secula, Florence; Bosch-Capblanch, Xavier; Namgyal, Pem; Hombach, Joachim

    2015-01-01

    Using meta-ethnographic methods, we conducted a systematic review of qualitative research to understand gender-related reasons at individual, family, community and health facility levels why millions of children in low and middle income countries are still not reached by routine vaccination programmes. A systematic search of Medline, Embase, CINAHL, Cochrane Library, ERIC, Anthropological Lit, CSA databases, IBSS, ISI Web of Knowledge, JSTOR, Soc Index and Sociological Abstracts was conducted. Key words were built around the themes of immunization, vaccines, health services, health behaviour, and developing countries. Only papers, which reported on in-depth qualitative data, were retained. Twenty-five qualitative studies, which investigated barriers to routine immunisation, were included in the review. These studies were conducted between 1982 and 2012; eighteen were published after 2000. The studies represent a wide range of low- to middle income countries including some that have well known coverage challenges. We found that women's low social status manifests on every level as a barrier to accessing vaccinations: access to education, income, as well as autonomous decision-making about time and resource allocation were evident barriers. Indirectly, women's lower status made them vulnerable to blame and shame in case of childhood illness, partly reinforcing access problems, but partly increasing women's motivation to use every means to keep their children healthy. Yet in settings where gender discrimination exists most strongly, increasing availability and information may not be enough to reach the under immunised. Programmes must actively be designed to include mitigation measures to facilitate women's access to immunisation services if we hope to improve immunisation coverage. Gender inequality needs to be addressed on structural, community and household levels if the number of unvaccinated children is to substantially decrease.

  19. European accomplishments in regulation of the family status of the child conceived by artificial reproduction technologies

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    Kovaček-Stanić Gordana

    2015-01-01

    Full Text Available In this paper, the author analyzes family status of the child conceived by artificial reproduction technologies using the following treatments: homologues artificial insemination, heterologus artificial insemination (artificial insemination by donor, ovum donation, embryo donation and surrogate motherhood. One specific situation of homologues artificial insemination is posthumous insemination, insemination after the death of the husband/partner. This procedure is allowed in, for instance, United Kingdom, but not allowed in France, Switzerland, and Italy. Considering genetics elements in this situation there is no doubt on fatherhood - father is a man whose sperm is used for insemination, regardless of the fact if frozen sperm or frozen embryo is used in the procedure. Nevertheless, until 2008 in United Kingdom, the husband/partner was not considered as legal father, because of the fact that the child was born after his death. Heterologous artificial insemination could be used in three different situations. First, when subjects are spouses or unmarried partners of different sexes. Second, when subjects are spouses or unmarried partners of the same sex and the third if a single woman is an only subject. Most recent procedure is the one in which subjects are spouses or unmarried partners of the same sex, specifically two women. This procedure is allowed in the United Kingdom and Sweden. In these legislatures, there is a rule that the woman who delivers the child is legal mother, and her spouse/partner is a second parent of the child. The most recent procedure of egg donation is a donation of only a part of an egg, mitochondrial DNA. In this case, there are in fact three genetic parents of the child: two genetic mothers and a father. Legally, the child has one mother (the woman who delivers a child and a father. One of potential outcomes of the recent research is the ability to create human embryo without any male genetic contribution - by

  20. Effect of child health status on parents’ allowing children to participate in pediatric research

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    Vanhelst Jérémy

    2013-02-01

    Full Text Available Abstract Background To identify motivational factors linked to child health status that affected the likelihood of parents’ allowing their child to participate in pediatric research. Methods Parents were invited to return their completed questionnaires anonymously to assess motivational factors and factors that might improve participation in pediatric research. Results Of 573 eligible parents, 261 returned the completed questionnaires. Of these, 126 were parents of healthy children (group 1, whereas 135 were parents of sick children who were divided into two groups according to the severity of their pathology, i.e., 99 ambulatory children (group 2 and 36 nonambulatory children (group 3. The main factor motivating participation in a pediatric clinical research study was “direct benefits for their child” (87.7%, 100%, and 100% for groups 1, 2, and 3, respectively. The other factors differed significantly between the three groups, depending on the child’s health status (all p 2 test, all p ≤ 0.04, depending on the child’s health status. The main factor was “a better understanding of the study and its regulation” for the healthy children and ambulatory sick children groups (31.2% and 82.1%, respectively, whereas this was the third factor for the nonambulatory sick children group (50%. Conclusions Innovative strategies should be developed based on a child’s health status to improve information provision when seeking a child’s participation in pediatric research. Parents would like to spend more time in discussions with investigators.

  1. Women's empowerment and child nutritional status in South Asia: a synthesis of the literature.

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    Cunningham, Kenda; Ruel, Marie; Ferguson, Elaine; Uauy, Ricardo

    2015-01-01

    Women's disempowerment is hypothesised to contribute to high rates of undernutrition among South Asian children. However, evidence for this relationship has not been systematically reviewed. This review of empirical studies aims to: (1) synthesise the evidence linking women's empowerment and child nutritional status in South Asia and (2) suggest directions for future research. We systematically searched Global Health, Embase (classic and Ovid), MEDLINE, Campbell Collaboration, Popline, Eldis, Web of Science, EconLit and Scopus. We generated 1661 studies for abstract and title screening. We full-text screened 44 of these, plus 10 additional studies the authors were aware of. Only 12 studies fulfilled our inclusion criteria. We included English materials published between 1990 and 2012 that examined the relationship(s) of at least one women's empowerment domain and nutritional status among South Asian children. Data were extracted and synthesised within three domains of empowerment: control of resources and autonomy, workload and time, and social support. The results showed women's empowerment to be generally associated with child anthropometry, but the findings are mixed. Inter-study differences in population characteristics, settings or methods/conceptualisations of women's empowerment, and the specific domains studied, likely contributed to these inconsistencies. This review also highlights that different women's empowerment domains may relate differently to child nutritional status. Future research should aim to harmonise definitions of women's empowerment, which key domains it should include, and how it is measured. Rigorous evaluation work is also needed to establish which policies and programmes facilitate women's empowerment and in turn, foster child nutritional well-being.

  2. Estimation of Nationwide Vaccination Coverage and Comparison of Interview and Telephone Survey Methodology for Estimating Vaccination Status

    Science.gov (United States)

    Park, Boyoung; Lee, Yeon-Kyeng; Cho, Lisa Y.; Go, Un Yeong; Yang, Jae Jeong; Ma, Seung Hyun; Choi, Bo-Youl; Lee, Moo-Sik; Lee, Jin-Seok; Choi, Eun Hwa; Lee, Hoan Jong

    2011-01-01

    This study compared interview and telephone surveys to select the better method for regularly estimating nationwide vaccination coverage rates in Korea. Interview surveys using multi-stage cluster sampling and telephone surveys using stratified random sampling were conducted. Nationwide coverage rates were estimated in subjects with vaccination cards in the interview survey. The interview survey relative to the telephone survey showed a higher response rate, lower missing rate, higher validity and a less difference in vaccination coverage rates between card owners and non-owners. Primary vaccination coverage rate was greater than 90% except for the fourth dose of DTaP (diphtheria/tetanus/pertussis), the third dose of polio, and the third dose of Japanese B encephalitis (JBE). The DTaP4: Polio3: MMR1 fully vaccination rate was 62.0% and BCG1:HepB3:DTaP4:Polio3:MMR1 was 59.5%. For age-appropriate vaccination, the coverage rate was 50%-80%. We concluded that the interview survey was better than the telephone survey. These results can be applied to countries with incomplete registry and decreasing rates of landline telephone coverage due to increased cell phone usage and countries. Among mandatory vaccines, efforts to increase vaccination rate for the fourth dose of DTaP, the third dose of polio, JBE and regular vaccinations at recommended periods should be conducted in Korea. PMID:21655054

  3. Estimation of nationwide vaccination coverage and comparison of interview and telephone survey methodology for estimating vaccination status.

    Science.gov (United States)

    Park, Boyoung; Lee, Yeon-Kyeng; Cho, Lisa Y; Go, Un Yeong; Yang, Jae Jeong; Ma, Seung Hyun; Choi, Bo-Youl; Lee, Moo-Sik; Lee, Jin-Seok; Choi, Eun Hwa; Lee, Hoan Jong; Park, Sue K

    2011-06-01

    This study compared interview and telephone surveys to select the better method for regularly estimating nationwide vaccination coverage rates in Korea. Interview surveys using multi-stage cluster sampling and telephone surveys using stratified random sampling were conducted. Nationwide coverage rates were estimated in subjects with vaccination cards in the interview survey. The interview survey relative to the telephone survey showed a higher response rate, lower missing rate, higher validity and a less difference in vaccination coverage rates between card owners and non-owners. Primary vaccination coverage rate was greater than 90% except for the fourth dose of DTaP (diphtheria/tetanus/pertussis), the third dose of polio, and the third dose of Japanese B encephalitis (JBE). The DTaP4: Polio3: MMR1 fully vaccination rate was 62.0% and BCG1:HepB3:DTaP4:Polio3:MMR1 was 59.5%. For age-appropriate vaccination, the coverage rate was 50%-80%. We concluded that the interview survey was better than the telephone survey. These results can be applied to countries with incomplete registry and decreasing rates of landline telephone coverage due to increased cell phone usage and countries. Among mandatory vaccines, efforts to increase vaccination rate for the fourth dose of DTaP, the third dose of polio, JBE and regular vaccinations at recommended periods should be conducted in Korea. PMID:21655054

  4. Knowledge of hepatitis B and vaccination status of some expatriate ethnic groups of blue collar workers in Northern Saudi Arabia

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    Abdul Sattar Khan

    2008-01-01

    Background: Hepatitis B (HBV infection is relatively common throughout the world, but more prevalent in low socioeconomic and underprivileged classes. The chronic infection may lead to severe consequences including Hepatocellular carcinoma (HCC. Method: A cross-sectional, community-based survey of some ethnic expatriate groups of blue color workers (n=665 living in four main areas along the Northern Borders of Saudi Arabia was completed in 2005. We examined knowledge of HBV and vaccination status and compared them with some socio-demographic factors. Results: The mean age of the participants was 45.61 years (±8.44, 53% of whom were Non-Arabs (Non Arabic speaking. Of the total, 41.6% gave seven or more correct answers out of 12 questions addressing knowledge about the transmission and sequelae of HBV. Almost 40% of the respondents had not been vaccinated while the remaining respondents had had three full doses of vaccination. A high level of knowledge (≥ 7 correct answers was significantly associated (p0.05 with level of knowledge. However, vaccination status was associated (p<0.05 with almost all socio-demographic factors. Conclusion: Hepatitis screening programs for expatriates in the Kingdom of Saudi Arabia started 10 years ago and are expected to have a great impact on the combat against HBV infections and their complications. However, beyond screening, health promotion, vaccination campaigns, and access to vaccine for the underprivileged classes are some necessary measures towards achieving success.

  5. Impact of requiring influenza vaccination for children in licensed child care or preschool programs--Connecticut, 2012-13 influenza season.

    Science.gov (United States)

    Hadler, James L; Yousey-Hindes, Kimberly; Kudish, Kathy; Kennedy, Erin D; Sacco, Vincent; Cartter, Matthew L

    2014-03-01

    Preschool-aged children are at increased risk for severe influenza-related illness and complications. Congregate child care settings facilitate influenza transmission among susceptible children. To protect against influenza transmission in these settings, in September 2010, Connecticut became the second U.S. state (after New Jersey) to implement regulations requiring that all children aged 6-59 months receive at least 1 dose of influenza vaccine each year to attend a licensed child care program. To evaluate the impact of this regulation on vaccination levels and influenza-associated hospitalizations during the 2012-13 influenza season, vaccination data from U.S. and Connecticut surveys and the Emerging Infections Program (EIP) were analyzed. After the regulation took effect, vaccination rates among Connecticut children aged 6-59 months increased from 67.8% during the 2009-10 influenza season to 84.1% during the 2012-13 season. During the 2012-13 influenza season, among all 11 EIP surveillance sites, Connecticut had the greatest percentage decrease (12%) in the influenza-associated hospitalization rate from 2007-08 among children aged ≤4 years. Additionally, the ratio of the influenza-associated hospitalization rates among children aged ≤4 years to the overall population rate (0.53) was lower than for any other EIP site. Requiring vaccination for child care admission might have helped to increase vaccination rates in Connecticut and reduced serious morbidity from influenza.

  6. Associations between women's autonomy and child nutritional status: a review of the literature.

    Science.gov (United States)

    Carlson, Gwen J; Kordas, Katarzyna; Murray-Kolb, Laura E

    2015-10-01

    Around the world, many women continue to experience low levels of autonomy. Recent literature has reported that the health consequences of low maternal autonomy extend beyond mothers and translate into health consequences for their children, and may be an important causal factor in child malnutrition. This review summarises the current knowledge of the relationship between maternal autonomy and children's nutritional status (defined as any measure that reflects the nutritional state of the body, such as birthweight or anthropometric scores) and child-feeding practices. The review also includes both discussion of the limitations found in the literature and directions for future research. A systematic review of the literature was conducted. Results of the studies included in the review strongly suggest that raising maternal autonomy is an important goal for improving children's nutritional status, yet gaps in the current knowledge exist, further confounded by issues with how autonomy is measured and limitations of cross-cultural comparability. A thorough understanding of the consequences of restricting women's autonomy will inform programmes and policy worldwide, and speed progress towards both empowering women and alleviating the global burden of child malnutrition.

  7. Rabies post-exposure prophylaxis for a child with severe allergic reaction to rabies vaccine.

    Science.gov (United States)

    Fang, Yuan; Liu, Man-Qing; Chen, Li; Zhu, Zheng-Gang; Zhu, Ze-Rong; Hu, Quan

    2016-07-01

    Most adverse events (AEs) during the immunization of rabies vaccine were slight, there was little information about the allergic reaction induced by rabies vaccines and had to stop or change the immunization program. Here, we reported a case that a 4-year-old boy had category II exposure to rabies and showed severe allergic reaction after being immunized with lyophilized purified vero cell rabies vaccine (PVRV). After the anti-allergy therapy with hormone, allergy testing indicated medium allergy to egg and milk, and implied the allergic reaction most likely associated with animal-sourced gelatin in lyophilized PVRV. Therefore, a new immunization program with liquid PVRV without stabilizers under the Zegrab regimen (2-1-1) was enrolled at day 7 post-exposure. Although lower than the levels of normal vaccines co-existing in the market, but also implied the necessary for doctors to fully understand the allergies history of patients prior to immunize rabies vaccine. PMID:26900624

  8. Correlates to Human Papillomavirus Vaccination Status and Willingness to Vaccinate in Low-Income Philadelphia High School Students

    Science.gov (United States)

    Bass, Sarah B.; Leader, Amy; Shwarz, Michelle; Greener, Judith; Patterson, Freda

    2015-01-01

    Background: Little is known about the correlates of human papillomavirus (HPV) vaccination or willingness to be vaccinated in urban, minority adolescents. Methods: Using responses to the 2013 Youth Risk Behavior Survey in Philadelphia, a random sample of high schools provided weighted data representing 20,941 9th to 12th graders. Stratified by…

  9. Maternal education is associated with vaccination status of infants less than 6 months in Eastern Uganda: a cohort study

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    Tumwine James K

    2010-12-01

    Full Text Available Abstract Background Despite provision of free childhood vaccinations, less than half of all Ugandan infants are fully vaccinated. This study compares women with some secondary schooling to those with only primary schooling with regard to their infants' vaccination status. Methods A community-based prospective cohort study conducted between January 2006 and May 2008 in which 696 pregnant women were followed up to 24 weeks post partum. Information was collected on the mothers' education and vaccination status of the infants. Results At 24 weeks, the following vaccinations had been received: bacille Calmette-Guérin (BCG: 92%; polio-1: 91%; Diphteria-Pertussis-Tetanus-Hepatitis B-Haemophilus Influenza b (DPT-HB-Hib 3 and polio-3: 63%. About 51% of the infants were fully vaccinated (i.e., had received all the scheduled vaccinations: BCG, polio 0, polio 1, DPT-HB-Hib1, polio 2, DPT-HB-Hib 2, polio 3 and DPT-HB-Hib 3. Only 46% of the infants whose mothers' had 5-7 years of primary education had been fully vaccinated compared to 65% of the infants whose mothers' had some secondary education. Infants whose mothers had some secondary education were less likely to miss the DPT-HB-Hib-2 vaccine (RR: 0.5, 95% CI: 0.3, 0.8, Polio-2 (RR: 0.4, 95%CI: 0.3, 0.7, polio-3 (RR: 0.5, 95%CI: 0.4, 0.7 and DPT-HB-Hib-3 (RR: 0.5, 95%CI: 0.4, 0.7. Other factors showing some association with a reduced risk of missed vaccinations were delivery at a health facility (RR = 0.8; 95%CI: 0.7, 1.0 and use of a mosquito net (RR: 0.8; 95%CI: 0.7, 1.0. Conclusion Infants whose mothers had a secondary education were at least 50% less likely to miss scheduled vaccinations compared to those whose mothers only had primary education. Strategies for childhood vaccinations should specifically target women with low formal education.

  10. Disconnective Hemispherotomy for Medically Intractable Status Epilepticus in an 8-Year-Old Child.

    Science.gov (United States)

    Bradley, Lucas; Bahgat, Diaa; Sharp, Gregory; Willis, Erin; Ocal, Eylem; Albert, Gregory; Serletis, Demitre

    2015-10-01

    We report here the unusual case of an 8-year-old child with left hemispheric focal epilepsy secondary to a perinatal infarction who presented with new onset absence seizures and eventual nonconvulsive status epilepticus that was refractory to medical management. Following review at our multidisciplinary Epilepsy Surgery conference, the patient underwent disconnective surgical hemispherotomy with immediate cessation of his seizures; and has remained seizure-free at 4 months following surgery. In this context, we present here an overview of hemispherectomy and related procedures, including peri-insular disconnective hemispherotomy, and we discuss the efficacy of surgery for challenging hemispheric epilepsies. PMID:26552284

  11. Evaluation of Child Self-perception Regarding Their Oro-dental Status

    OpenAIRE

    Krisztina Mártha I.; Sorana Roșu; Réka Gyergyay; Katalin Vikárius

    2013-01-01

    Aim: The aim of this study was to evaluate the state of oral health and the self-perception of children regarding their oro-dental status, their knowledge and attitude towards oral health. Methods: A sample of 130 children (11-14 years) and one of their parents were asked to complete a Child Perception Questionnaire (CPQ11-14) in Sfântu Gheorghe, Romania. From these, 69 children were examined and data was recorded about Decayed-Missing-Filled Teeth (DMFT), oral hygiene, dental malposition and...

  12. Maternal employment, child care, and nutritional status of 12-18-month-old children in Managua, Nicaragua.

    Science.gov (United States)

    Lamontagne, J F; Engle, P L; Zeitlin, M F

    1998-02-01

    Relationships among women's employment, child care strategies, and nutritional status of children 12-18 months of age were examined in 80 Nicaraguan households sampled by randomized block design in 10 low income urban communities. Multiple regression analyses showed that children of employed mothers (56%) fared better in weight/height than those whose mothers were not employed, with and without controlling for socioeconomic status and maternal education, paternal financial support, child care adequacy, and sex and age of the child. Children with inadequate alternate child care (care by a preteen or care at the work place) had lower height for age, even controlling for the same variables and for maternal employment. Differences in 10 caregiving behaviors between families as a function of work status of the mother and adequacy of child care were examined. In families with working mothers, caregivers were less likely to be observed washing their hands, suggesting that the positive associations of work for earnings might be due to income rather than improved care. Inadequate care was associated with less food variety, less use of health care, and marginally less hand-washing. Inadequate child care, which tends to be associated with informal work, nuclear families and poverty, should be a concern for child welfare. PMID:9460821

  13. Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

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    Mamiko Niki

    2015-01-01

    Full Text Available Although tuberculosis remains a major global health problem, Bacille Calmette-Guérin (BCG is the only available vaccine. However, BCG has limited applications, and a more effective vaccine is needed. Cellular mediated immunity (CMI is thought to be the most important immune response for protection against Mycobacterium tuberculosis (Mtb. However, the recent failure of a clinical trial for a booster BCG vaccine and increasing evidence of antibody-mediated immunity prompted us to evaluate humoral immunity to Mtb-specific antigens. Using Enzyme-Linked ImmunoSpot and Enzyme-Linked ImmunoSorbent Assays, we observed less correlation of both CMI and IgG titers with patient clinical status, including serum concentration of C reactive protein. However, IgA titers against Mtb were significantly correlated with clinical status, suggesting that specific IgA antibodies protect against Mtb proliferation. In addition, in some cases, IgA antibody titers were significantly associated with the serum concentration of total albumin, which supports the idea that humoral immunity can be influenced by the nutritional status. Based on these observations, we propose that the induction of humoral immunity should be included as an option in TB vaccine development strategies.

  14. Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development.

    Science.gov (United States)

    Niki, Mamiko; Suzukawa, Maho; Akashi, Shunsuke; Nagai, Hideaki; Ohta, Ken; Inoue, Manabu; Niki, Makoto; Kaneko, Yukihiro; Morimoto, Kozo; Kurashima, Atsuyuki; Kitada, Seigo; Matsumoto, Sohkichi; Suzuki, Koichi; Hoshino, Yoshihiko

    2015-01-01

    Although tuberculosis remains a major global health problem, Bacille Calmette-Guérin (BCG) is the only available vaccine. However, BCG has limited applications, and a more effective vaccine is needed. Cellular mediated immunity (CMI) is thought to be the most important immune response for protection against Mycobacterium tuberculosis (Mtb). However, the recent failure of a clinical trial for a booster BCG vaccine and increasing evidence of antibody-mediated immunity prompted us to evaluate humoral immunity to Mtb-specific antigens. Using Enzyme-Linked ImmunoSpot and Enzyme-Linked ImmunoSorbent Assays, we observed less correlation of both CMI and IgG titers with patient clinical status, including serum concentration of C reactive protein. However, IgA titers against Mtb were significantly correlated with clinical status, suggesting that specific IgA antibodies protect against Mtb proliferation. In addition, in some cases, IgA antibody titers were significantly associated with the serum concentration of total albumin, which supports the idea that humoral immunity can be influenced by the nutritional status. Based on these observations, we propose that the induction of humoral immunity should be included as an option in TB vaccine development strategies. PMID:26568961

  15. Are Improvements in Child Health Due to Increasing Status of Women in Developing Nations?

    Science.gov (United States)

    Heaton, Tim B

    2015-01-01

    This research tests the hypothesis that change over time in women's status leads to improvements in their children's health. Specifically, we examine whether change in resources and empowerment in mother's roles as biological mothers, caregivers, and providers and social contexts that promote the rights and representation of and investment in women are associated with better nutritional status and survival of young children. Analysis is based on a broad sample of countries (n = 28), with data at two or more points in time to enable examination of change. Key indicators of child health show improvement in the last 13 years in developing nations. Much of this improvement--90 percent of the increase in nutritional status and 47 percent of the reduction in mortality--is associated with improving status of women. Increased maternal education, control over reproduction, freedom from violence, access to health care, legislation and enforcement of women's rights, greater political representation, equality in the education system, and lower maternal mortality are improving children's health. These results imply that further advancement of women's position in society would be beneficial. PMID:26652680

  16. Maternal child-rearing attitudes, IQ, and socioeconomic status as related to cognitive abilities of five-year-old children.

    Science.gov (United States)

    Andersson, H W; Sommerfelt, K; Sonnander, K; Ahlsten, G

    1996-08-01

    The effects of maternal child-rearing attitudes, as measured by the Child Rearing Practices Report, on 5-yr.-old children's Verbal IQ and Performance IQ were investigated in a Scandinavian sample of 108 boys and 126 girls. The maternal child-rearing attitude of Restrictiveness, as defined by scores on the Report, showed negative relations to the cognitive measures. However, the significant negative relation between Restrictiveness and Verbal IQ, obtained for both sexes, disappeared when the effects of maternal IQ and socioeconomic status were controlled. The maternal child-rearing attitude of Nurturance, as defined by scores on the Report, was significantly related to Verbal IQ and Performance IQ for boys only. Significant relationships between scores on Nurturance and cognitive abilities of boys remained when the effects of maternal IQ and socioeconomic status were controlled. PMID:8873781

  17. Immunization Status Against Hepatitis B Among Iranian Junior Medical, Nursing, and Obstetrics Students With Different Vaccination Patterns

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    Allami

    2015-08-01

    Full Text Available Background Since the protection time by hepatitis B (HB vaccination is unclear, the strategy of immunization of junior students who previously received hepatitis vaccine is controversial. Objectives This study aimed to determine the status of immunity to hepatitis B in junior medical, nursing and obstetrics students with different hepatitis B virus (HBV vaccination patterns. Patients and Methods In an analytical cross-sectional study, 255 junior medical sciences students were tested for quantitative antibodies to hepatitis B surface antigen (anti-HBs. The proportion of protective immunity was compared in different vaccination patterns. Results Vaccination coverage rates were 74.1%. About half the participants didn’t show serological evidence of protective immunity; 68.9% had their last shot more than 10 years ago and 30.4% had a vaccination history of five years or less (P < 0.001. Geometric mean level of anti-HBs titer among students, who had received a primary series vaccine at birth, was significantly lower than students who had started vaccination at an older age (P < 0.001. Also, analysis of variance for geometric mean of anti-HBs titer showed significant differences between groups based on injection time from the last shot (P < 0.001 (post hoc comparisons resulted in a P value of < 0.001 for birth versus < 5 year group, and P < 0.001 for the 5 to 10 year group. The lowest rate of non-protective level belonged to participants with complete three doses and a booster additional shot (27.1%. The final model for independent predictors of anti-HBs positive status was made by a binary logistic regression analysis. The model included presence of a booster dose, injection time from last shot, and discipline of study. Conclusions This study shows lower anti-HBs among students who were vaccinated at infancy compared to those vaccinated at older childhood or adolescence. Also, subsequent measurement of anti-HBs level at the time of entrance to

  18. Status of pandemic influenza vaccination and factors affecting it in pregnant women in Kahramanmaras, an eastern Mediterranean city of Turkey.

    Directory of Open Access Journals (Sweden)

    Ali Ozer

    Full Text Available BACKGROUND: Pregnant women are a target group for receipt of influenza vaccine because there appears to be an elevated mortality and morbidity rate associated with influenza virus infection in pregnant women. The goal of this study is to determine the factors affecting the decisions of pregnant women in Turkey to be vaccinated or not for 2009 H1N1 influenza. METHODOLOGY: We enrolled 314 of 522 (60.2% pregnant women who attended to the antenatal clinics of the Medical Faculty of Kahramanmaras Sutcuimam University's Department of Gynecology and Obstetrics between December 23, 2009, and February 1, 2010. We developed a 48-question survey which was completed in a face-to-face interview at the clinic with each pregnant woman. PRINCIPAL FINDINGS: Of the 314 pregnant women, 27.4% were in the first trimester, 33.8% were in the second trimester, and 38.8% were in the third trimester. Twenty-eight pregnant women (8.9% got vaccinated. Of all the women interviewed, 68.5% stated that they were comfortable with their decisions about the vaccine, 7.3% stated they were not comfortable, and 24.2% stated that they were hesitant about their decisions. The probability of receiving the 2009 H1N1 vaccine was 3.46 times higher among working women than housewives, 1.85 times higher among women who have a child than those who do not, and 1.29 times higher among women with a high-school education or higher than those with only a secondary-school education and below. Correct knowledge about the minimal risks associated with receipt of influenza vaccine were associated with a significant increase in the probability of receiving the 2009 H1N1 vaccine. CONCLUSIONS/SIGNIFICANCE: The number of pregnant women in the study group who received the 2009 H1N1 vaccine was very low (8.9% and two-thirds of them stated that they were comfortable with their decisions concerning the vaccine. Our results may have implications for public health measures to increase the currently low

  19. The Influence of Child and Parent Health Literacy Status on Health Outcomes from a Childhood Obesity Treatment Program

    OpenAIRE

    Lowery, Kamilan Aurielle

    2016-01-01

    While limited health literacy has been associated with poorer health decisions and poorer health outcomes, there remains a gap in the literature related to the influence of health literacy on weight and weight-related behaviors. The primary aim of this study is to examine the influence of child and parent health literacy status on childs body mass index (BMI) and health behaviors, within an adapted evidence-based family-based childhood obesity intervention, iChoose, implemented in the medical...

  20. Antioxidant status in pregnant ewes vaccinated with Rev 1 against brucellosis

    Directory of Open Access Journals (Sweden)

    W. S. Al- Khafaji

    2012-01-01

    Full Text Available The aim of this study was to examine the changes in the indicators of free radicals and antioxidant activity, represented by malondialdehyde and glutathione peroxidase in the sera of ewes vaccinated with Rev 1 vaccine. The experiment included 28 animals which were divided into four equal groups. Animals of the first and second groups were vaccinated subcutaneously with 2×109 and 2×107 colony forming units (CFU, respectively, whereas the animals of third and fourth groups were vaccinated conjunctively with 2×109 and 2×107 CFU, respectively. Sera were collected monthly for 6 months. Antibody responses were assessed by classical tests (Rose Bengal test, tube agglutination and 2-mercaptoethanol tests in comparison with competitive ELISA. The antibody titers were higher and remained for along period in the subcutaneously vaccinated groups with the two doses compared those vaccinated conjunctively. There was a significant increase in serum glutathione peroxidase activity in the 8th week post vaccination in subcutaneously vaccinated groups and during the 12th week in those vaccinated conjunctively. Significant increase of serum malondialdehyde levels occurred during the 4th week in those vaccinated conjunctively and in 8th week in those vaccinated subcutaneously. This study concluded that the route of administration of the vaccine affects glutathione peroxidase activity and malondialdehyde level, which act as indicators of oxidative stress response, more than the vaccine dose.

  1. Current status and prospects of typhoid vaccines%伤寒疫苗的现状及展望

    Institute of Scientific and Technical Information of China (English)

    潘殊男

    2011-01-01

    Typhoid fever is still a major public health problem in developing countries.Vaccination is the most effective measure to control typhoid fever.This article describes safety and efficacy of early and current typhoid vaccines,and discusses current status of development and research and application prospects of Salmonella typhi Vi polysaccharide conjugate vaccine.%伤寒仍是发展中国家的主要公共卫生问题,控制伤寒的最有效措施是接种疫苗.此文介绍了早期伤寒疫苗和现行伤寒疫苗的的安全性和有效性,讨论了伤寒Vi多糖结合疫苗的研发现状及应用前景.

  2. [Individual versus collective protection: bioethical analysis of the national program of mass child vaccination].

    Science.gov (United States)

    Lessa, Sérgio de Castro; Schramm, Fermin Roland

    2015-01-01

    Vaccination is considered one of the most efficient and cost-effective public health policies most used in the control and prevention of disease. However, it is also one of the most polemic and controversial biomedical techniques, making it difficult to avoid an ethical dilemma, especially when vaccination is compulsory for the entire population. Indeed, since vaccines are not totally effective and safe, there is an ethical conflict between the individual and the collective interest, because children effectively carry the burden of vaccination for the benefit of public health when they are affected with serious adverse reactions and do not benefit from the care that should be offered by the government. The objective of this article was to demonstrate that the tools of bioethics are relevant in this discussion to understand and analyze these dilemmas critically by providing convincing arguments to underpin the development of biopolitics that consider prevention not only rigorously, but also the joint responsibility of all as fundamental for individual and collective protection.

  3. How does parents' visual perception of their child's weight status affect their feeding style?

    Directory of Open Access Journals (Sweden)

    Resul Yilmaz

    2013-06-01

    Full Text Available Introduction: Eating style is one of the prominent factors that determine energy intake. One of the influencing factors that determine parental feeding style is parental perception of the weight status of the child. Aim: The aim of this study is to evaluate the relationship between maternal visual perception of their children's weight status and their feeding style. Method: A cross-sectional survey was completed with only mother's of 380 preschool children with age of 5 to 7 (6.14 years. Visual perception scores were measured with a sketch and maternal feeding style was measured with validated "Parental Feeding Style Questionnaire". Results: The parental feeding dimensions "emotional feeding" and "encouragement to eat" subscale scores were low in overweight children according to visual perception classification. "Emotional feeding" and "permissive control" subscale scores were statistically different in children classified as correctly perceived and incorrectly low perceived group due to maternal misperception. Conclusion: Various feeding styles were related to maternal visual perception. The best approach to preventing obesity and underweight may be to focus on achieving correct parental perception of the weight status of their children, thus improving parental skills and leading them to implement proper feeding styles.

  4. KNOWLEDGE OF HEPATITIS B AND VACCINATION STATUS OF SOME EXPATRIATE ETHNIC GROUPS OF BLUE COLLAR WORKERS IN NORTHERN SAUDI ARABIA

    OpenAIRE

    Abdul Sattar Khan; Maisa Al-Sweilem; Zekeriya Akturk

    2008-01-01

    Objective: To find out the level of knowledge and vaccination status of some expatriate ethnic groups of blue color workers. Background: Hepatitis B (HBV) infection is relatively common throughout the world, but more prevalent in low socioeconomic and underprivileged classes. The chronic infection may lead to severe consequences including Hepatocellular carcinoma (HCC). Method: A cross-sectional, community-based survey of some ethnic expatriate groups of blue color workers (n=665) livi...

  5. Conflict Competence of Preschool Children and its Relationship with the Sociometric Status of the Child in the Peer Group

    OpenAIRE

    Denisenkova N.S.,; Vyrotskova V.V.

    2015-01-01

    The purpose of the study was to investigate the conflict competence of children of preschool age and identification of its relationship with the child's sociometric status in the peer group. The hypothesis of the study was that there is a relationship between the sociometric status of preschoolers in the peer group and the strategy of their behavior in a conflict situation, a conflict of competence. The study involved children (41 children: 22 boys and 19 girls) aged 5-7 years, attending prep...

  6. Nutritional status and cognitive performance of mother-child pairs in Sidama, Southern Ethiopia.

    Science.gov (United States)

    Bogale, Alemtsehay; Stoecker, Barbara J; Kennedy, Tay; Hubbs-Tait, Laura; Thomas, David; Abebe, Yewelsew; Hambidge, K Michael

    2013-04-01

    The purpose of this study was to assess the nutritional status and cognitive performance of women and their 5-year-old children using a cross-sectional design. Cognitive performance of mothers and children was assessed with Raven's Colored Progressive Matrices (CPM) and Kaufman Assessment Battery for Children-II (KABC-II). Demographic characteristics, food consumption patterns and anthropometry were also measured. Four rural districts in Sidama, southern Ethiopia served as the setting for this study. Subjects were one hundred women and their 5-year-old children. Mean ± standard deviation age of the mothers was 29 ± 6 years and family size was 7.0 ± 2.6. Maternal body mass index (BMI) ranged from 15.3 to 29.0 with 14% of the mothers having BMI child health but also cognitive function.

  7. Association of maternal and child nutritional status in Brazil: a population based cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Mariana Santos Felisbino-Mendes

    Full Text Available BACKGROUND: Although child undernutrition and stunting has been decreasing worldwide while obesity rates increase, these extreme conditions might coexist in families from low- and middle-income countries. We examined the association between maternal and child anthropometric indicators using a population representative sample. METHODS: 4,258 non-pregnant women and their children 2. RESULTS: HAZ was positively associated with maternal height and WC in a linear fashion. After adjustment, for sociodemographic characteristics, children whose mothers' height was<145 cm had 1.2 lower HAZ than children whose mothers were ≥160 cm tall (p-trend<0.0001. After further adjustment for maternal height and maternal BMI, children of mothers with a waist circumference ≥88 cm had 0.3 higher HAZ than those of mothers with WC<80 cm (p-trend<0.01. Adjusted prevalence ratios and 95% CI for stunting by the categories of maternal height (<145, 145-149, 150-154, 155-159 and ≥160 cm were, respectively, 2.95 (1.51;5.77, 2.29 (1.33;3.93, 1.09 (0.63;1.87, and 0.89 (0.45;1.77, (p-trend = 0.001. BAZ was positively associated with maternal BMI and WC. CONCLUSION: We observed a strong, positive association of maternal and child nutritional status. Mothers of low stature had children with lower stature, mothers with central obesity had taller children, and mothers with overall or abdominal obesity had children with higher BAZ.

  8. Lack of a Negative Effect of BCG-Vaccination on Child Psychomotor Development

    DEFF Research Database (Denmark)

    Kjærgaard, Jesper; Stensballe, Lone Graff; Birk, Nina Marie;

    2016-01-01

    MEASURES: Psychomotor development measured using Ages and Stages Questionnaire (ASQ) completed by the parents at 12 months. Additionally, parents of premature children (gestational age Developmental assessment was available for 3453/4262 (81%). RESULTS......OBJECTIVES: To assess the non-specific effect of Bacillus Calmette-Guérin (BCG) vaccination at birth on psychomotor development. DESIGN: This is a pre-specified secondary outcome from a randomised, clinical trial. SETTING: Maternity units and paediatric wards at three university hospitals...... was -7.8 points (-20.6 to 5.0, p = 0.23), d = -0.23 (-0.62 to 0.15). CONCLUSIONS: A negative non-specific effect of BCG vaccination at birth on psychomotor development was excluded in term children. TRIAL REGISTRATION: ClinicalTrials.gov NCT01694108....

  9. Nutritional status of women and child refugees from Syria-Jordan, April-May 2014.

    Science.gov (United States)

    Bilukha, Oleg O; Jayasekaran, Douglas; Burton, Ann; Faender, Gabriele; King'ori, James; Amiri, Mohammad; Jessen, Dorte; Leidman, Eva

    2014-07-25

    As a result of civil war, an estimated 2.8 million refugees have fled Syria and reside in neighboring countries, mainly Lebanon, Turkey, Jordan, and Iraq. The largest Syrian refugee camp in the region is Zaatari camp in Jordan, with approximately 79,000 refugees; another estimated 500,000 Syrian refugees live in Jordanian cities, towns, and villages, mostly in the capital (Amman) and in four northern governorates (Irbid, Mafraq, Jarash, and Zarqa). Although all registered refugees in Jordan receive food vouchers from the World Food Programme (WFP) and vulnerable refugees receive cash assistance from the United Nations High Commissioner for Refugees (UNHCR) and nongovernmental organizations, the nutritional status of some refugees might be compromised because of dislocation, lack of income, and limited access to nutritious foods. To assess the nutritional status of Syrian refugees, UNHCR, WFP, the United Nations Children's Fund (UNICEF), Medair International (a nongovernmental organization), and CDC, in collaboration with the United Nations Population Fund and the World Health Organization (WHO), conducted cross-sectional, population-representative cluster surveys in Zaatari camp and among refugees residing in the host community. The surveys were conducted during April-May 2014 with the principal objective of assessing nutritional status of refugee children aged 6-59 months and nonpregnant women of reproductive age (15-49 years). Preliminary findings indicated a high prevalence of anemia in Zaatari camp among both children and women (48.4% and 44.8%, respectively). Nutrition policies aimed at ensuring optimal child and maternal micronutrient status and addressing the underlying risk factors for anemia are likely to result in improved health outcomes and a reduction in anemia.

  10. Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction.

    Science.gov (United States)

    Renukaradhya, Gourapura J; Meng, Xiang-Jin; Calvert, Jay G; Roof, Michael; Lager, Kelly M

    2015-06-17

    Within a few years of its emergence in the late 1980s, the PRRS virus had spread globally to become the foremost infectious disease concern for the pork industry. Since 1994, modified live-attenuated vaccines against porcine reproductive and respiratory syndrome virus (PRRSV-MLV) have been widely used, but have failed to provide complete protection against emerging and heterologous field strains of the virus. Moreover, like many other MLVs, PRRSV-MLVs have safety concerns including vertical and horizontal transmission of the vaccine virus and several documented incidences of reversion to virulence. Thus, the development of efficacious inactivated vaccines is warranted for the control and eradication of PRRS. Since the early 1990s, researchers have been attempting to develop inactivated PRRSV vaccines, but most of the candidates have failed to elicit protective immunity even against homologous virus challenge. Recent research findings relating to both inactivated and subunit candidate PRRSV vaccines have shown promise, but they need to be pursued further to improve their heterologous efficacy and cost-effectiveness before considering commercialization. In this comprehensive review, we provide information on attempts to develop PRRSV inactivated and subunit vaccines. These includes various virus inactivation strategies, adjuvants, nanoparticle-based vaccine delivery systems, DNA vaccines, and recombinant subunit vaccines produced using baculovirus, plant, and replication-deficient viruses as vector vaccines. Finally, future directions for the development of innovative non-infectious PRRSV vaccines are suggested. Undoubtedly there remains a need for novel PRRSV vaccine strategies targeted to deliver cross-protective, non-infectious vaccines for the control and eradication of PRRS.

  11. At Risk: The Relationship between Experiences of Child Sexual Abuse and Women's HIV Status in Papua New Guinea

    Science.gov (United States)

    Lewis, Ione R.

    2012-01-01

    Child sexual abuse in Papua New Guinea is a human rights issue as well as an indicator of HIV risk in women. This study aimed to develop knowledge about the link between violence experienced by women and their HIV status. The study used a mixed method approach to collect quantitative and qualitative data through structured interviews with a sample…

  12. Child's Weight Status and Parent's Response to a School-Based Body Mass Index Screening and Parent Notification Program

    Science.gov (United States)

    Lee, Jiwoo; Kubik, Martha Y.

    2015-01-01

    This study examined the response of parents of elementary school-aged children to a school-based body mass index (BMI) screening and parent notification program conducted in one Minnesota school district in 2010-2011 and whether parent's response was moderated by child's weight status. Randomly selected parents (N = 122) of second- and…

  13. Effect of socioeconomic status disparity on child language and neural outcome: how early is early?

    Science.gov (United States)

    Hurt, Hallam; Betancourt, Laura M

    2016-01-01

    It is not news that poverty adversely affects child outcome. The literature is replete with reports of deleterious effects on developmental outcome, cognitive function, and school performance in children and youth. Causative factors include poor nutrition, exposure to toxins, inadequate parenting, lack of cognitive stimulation, unstable social support, genetics, and toxic environments. Less is known regarding how early in life adverse effects may be detected. This review proposes to elucidate "how early is early" through discussion of seminal articles related to the effect of socioeconomic status on language outcome and a discussion of the emerging literature on effects of socioeconomic status disparity on brain structure in very young children. Given the young ages at which such outcomes are detected, the critical need for early targeted interventions for our youngest is underscored. Further, the fiscal reasonableness of initiating quality interventions supports these initiatives. As early life adversity produces lasting and deleterious effects on developmental outcome and brain structure, increased focus on programs and policies directed to reducing the impact of socioeconomic disparities is essential. PMID:26484621

  14. Towards a sustainable, quality and affordable Haemophilus influenzae type b vaccine for every child in the world

    NARCIS (Netherlands)

    Hamidi, A.

    2016-01-01

    Haemophilus influenzae type b (Hib) conjugate vaccine is a safe and effective vaccine that can prevent meningitis and pneumonia caused by Hib disease. Hib vaccine is recommended for all children under 5 years. Despite the availability of safe and effective Hib vaccines since early 1987, Gambia was t

  15. Heterologous and sex differential effects of administering vitamin A supplementation with vaccines

    OpenAIRE

    Jensen, Kristoffer J.; Ndure, Jorjoh; Plebanski, Magdalena; Flanagan, Katie L.

    2014-01-01

    WHO recommends high-dose vitamin A supplementation (VAS) to children from 6 months to 5 years of age in low-income countries, in order to prevent and treat vitamin A deficiency-associated morbidity and mortality. The current policy does not discriminate this recommendation either by sex or vaccination status of the child. There is accumulating evidence that the effects of VAS on morbidity, mortality and immunological parameters depend on concomitant vaccination status. Moreover, these interac...

  16. Status and future perspectives of vaccines for industrialised fin-fish farming.

    Science.gov (United States)

    Brudeseth, Bjørn Erik; Wiulsrød, Rune; Fredriksen, Børge Nilsen; Lindmo, Karine; Løkling, Knut-Egil; Bordevik, Marianne; Steine, Nils; Klevan, Are; Gravningen, Kjersti

    2013-12-01

    Fin fish farming is developing from extensive to intensive high industrial scale production. Production of fish in high-density growth conditions requires effective vaccines in order to control persistent and emerging diseases. Vaccines can also have significant positive impact on the reduced usage of antibiotics. This was demonstrated when vaccines were introduced in Norway for Atlantic salmon (Salmo salar) in the late eighties and early nineties, resulting in a rapid decline of antibiotics consumption. The present review will focus on current vaccine applications for farmed industrialized fish species such as Atlantic salmon, coho salmon (Oncorhynchus kisutch), rainbow trout (Oncorhynchus mykiss), ayu (Plecoglossus altivelis), cod (Gadus morhua), sea bass (Dicentrarchus labrax), gilt-head sea bream (Sparus aurata), yellowtail (Seriola quinqueradiata), great amberjack (Seriola dumerili), barramundi (Lates calcarifer), japanese flounder (Paralichythys olivaceus), turbot (Scophthalmus maximus), red sea bream (Pagrus major), rock bream (Oplegnathus fasciatus), seven band grouper (Epinephelus septemfasciatus), striped catfish (Pangasianodon hypophthalmus), channel catfish (Ictalurus punctatus) and tilapia (Oreochromis niloticus). This paper will review the current use of licensed vaccines in fin fish farming and describe vaccine administration regimes including immersion, oral and injection vaccination. Future trends for inactivated-, live attenuated - and DNA - vaccines will also be discussed.

  17. Status and future perspectives of vaccines for industrialised fin-fish farming.

    Science.gov (United States)

    Brudeseth, Bjørn Erik; Wiulsrød, Rune; Fredriksen, Børge Nilsen; Lindmo, Karine; Løkling, Knut-Egil; Bordevik, Marianne; Steine, Nils; Klevan, Are; Gravningen, Kjersti

    2013-12-01

    Fin fish farming is developing from extensive to intensive high industrial scale production. Production of fish in high-density growth conditions requires effective vaccines in order to control persistent and emerging diseases. Vaccines can also have significant positive impact on the reduced usage of antibiotics. This was demonstrated when vaccines were introduced in Norway for Atlantic salmon (Salmo salar) in the late eighties and early nineties, resulting in a rapid decline of antibiotics consumption. The present review will focus on current vaccine applications for farmed industrialized fish species such as Atlantic salmon, coho salmon (Oncorhynchus kisutch), rainbow trout (Oncorhynchus mykiss), ayu (Plecoglossus altivelis), cod (Gadus morhua), sea bass (Dicentrarchus labrax), gilt-head sea bream (Sparus aurata), yellowtail (Seriola quinqueradiata), great amberjack (Seriola dumerili), barramundi (Lates calcarifer), japanese flounder (Paralichythys olivaceus), turbot (Scophthalmus maximus), red sea bream (Pagrus major), rock bream (Oplegnathus fasciatus), seven band grouper (Epinephelus septemfasciatus), striped catfish (Pangasianodon hypophthalmus), channel catfish (Ictalurus punctatus) and tilapia (Oreochromis niloticus). This paper will review the current use of licensed vaccines in fin fish farming and describe vaccine administration regimes including immersion, oral and injection vaccination. Future trends for inactivated-, live attenuated - and DNA - vaccines will also be discussed. PMID:23769873

  18. Current status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticles

    Directory of Open Access Journals (Sweden)

    Taguchi Hiroaki

    2011-08-01

    Full Text Available Abstract Many studies are currently investigating the development of safe and effective vaccines to prevent various infectious diseases. Multiple antigen-presenting peptide vaccine systems have been developed to avoid the adverse effects associated with conventional vaccines (i.e., live-attenuated, killed or inactivated pathogens, carrier proteins and cytotoxic adjuvants. Recently, two main approaches have been used to develop multiple antigen-presenting peptide vaccine systems: (1 the addition of functional components, e.g., T-cell epitopes, cell-penetrating peptides, and lipophilic moieties; and (2 synthetic approaches using size-defined nanomaterials, e.g., self-assembling peptides, non-peptidic dendrimers, and gold nanoparticles, as antigen-displaying platforms. This review summarizes the recent experimental studies directed to the development of multiple antigen-presenting peptide vaccine systems.

  19. Status of research and development of pediatric vaccines for Streptococcus pneumoniae.

    Science.gov (United States)

    Alderson, Mark R

    2016-06-01

    Pneumococcal disease is a major cause of morbidity and mortality in young children, particularly in the developing world. Vaccines are a critical strategy for protecting children from pneumococcal disease and licensed pneumococcal conjugate vaccines (PCVs) are having a significant impact on invasive pneumococcal disease and pneumococcal pneumonia throughout the world. Currently available PCVs do not, however, cover all pneumococcal serotypes and are complicated and relatively expensive to manufacture. While new PCV development is focused on either higher valency or more inherent affordability for developing countries, new vaccines are needed that offer serotype-independent protection. Vaccines containing proteins that are common to all pneumococcal serotypes could provide broad protection to children worldwide. Protein subunit and whole cell vaccines have advanced into Phase 1 and 2 clinical trials but face considerable challenges before they can become licensed and widely distributed. PMID:27083428

  20. Current status of a hepatitis C vaccine: encouraging results but significant challenges ahead

    DEFF Research Database (Denmark)

    Mikkelsen, Marianne; Bukh, Jens

    2007-01-01

    Persistent hepatitis C virus (HCV) infection affects 170 million people worldwide. Acute HCV infection is often asymptomatic, but many infected individuals develop persistent infections that may lead to development of end-stage liver diseases, including liver cirrhosis and hepatocellular carcinoma....... Thus, an HCV vaccine that could significantly lower the chronicity rate would have a major impact on the disease burden. Unfortunately, HCV is a highly mutable virus, and escape mutations can undermine vaccine-induced virus-specific immunity. Also, HCV exists as multiple genotypes, and so genotype......-specific vaccines might be required to achieve broad protection. Finally, vaccine development has been hampered by the lack of a small animal model and cell culture systems, but these are currently being established. Despite these obstacles, several vaccine candidates tested in the chimpanzee HCV model have shown...

  1. Reduced All-Cause Child Mortality After General Measles Vaccination Campaign in Rural Guinea-Bissau

    DEFF Research Database (Denmark)

    Fisker, Ane Bærent; Rodrigues, Amabelia; Martins, Cesario;

    2015-01-01

    BACKGROUND: Randomised trials have shown that measles vaccine (MV) prevents non-measles deaths. MV-campaigns are conducted to eliminate measles infection.The overall mortality effect of MV-campaigns has not been studied. METHODS: Bandim Health Project (BHP) surveys children aged 0-4 years in rural...... Guinea-Bissau through a health and demographic surveillance system. A nationalMV-campaign in 2006 targeted children aged 6 months-15 years. In a Cox proportional-hazards model with age as underlying time-scale we compared mortality for children aged 6-59 months after the campaign with mortality...... in the same age group during the two previous years. RESULTS: 8158 children aged 6-59 months were under BHP surveillance during the 2006-campaign and 7999 and 8108 during similar periods in 2004 and 2005. At least 90% of the eligible children received MV in the campaign. There were 161 non-accident deaths...

  2. Green Space and Child Weight Status: Does Outcome Measurement Matter? Evidence from an Australian Longitudinal Study

    Directory of Open Access Journals (Sweden)

    Taren Sanders

    2015-01-01

    Full Text Available Objective. To examine whether neighbourhood green space is beneficially associated with (i waist circumference (WC and (ii waist-to-height ratio (WtHR across childhood. Methods. Gender-stratified multilevel linear regressions were used to examine associations between green space and objective measures of weight status in the Longitudinal Study of Australian Children, a nationally representative source of data on 4,423 children aged 6 y to 13 y. WC and WtHR were measured objectively. Percentage green space within the local area of residence was calculated. Effect modification by age was explored, adjusting for socioeconomic confounding. Results. Compared to peers with 0–5% green space locally, boys and girls with >40% green space tended to have lower WC (βboys  −1.15, 95% CI −2.44, 0.14; βgirls  −0.21, 95% CI −1.47, 1.05 and WtHR (βboys  −0.82, 95% CI −1.65, 0.01; βgirls  −0.32, 95% CI −1.13, 0.49. Associations among boys were contingent upon age (p  valuesage∗green  space40% green space at 73.85 cm and 45.75% compared to those with 0–5% green space at 75.18 cm and 46.62%, respectively. Conclusions. Greener neighbourhoods appear beneficial to alternative child weight status measures, particularly among boys.

  3. Rough vaccines in animal brucellosis: Structural and genetic basis and present status

    OpenAIRE

    Moriyon, I. (Ignacio); Grillo, M.J. (María Jesús); Monreal, D.; Gonzalez-fernandez, D.; Marin, C.M.; Lopez-Goñi, I. (Ignacio); Mainar, R. (Raúl); Moreno, E.; Blasco, J.M. (José)

    2004-01-01

    International audience - Brucellosis control and eradication requires serological tests and vaccines. Effective classical vaccines (S19 in cattle and Rev 1 in small ruminants), however, induce antibodies to the O-polysaccharide of the lipopolysaccharide which may be difficult to distinguish from those resulting from infection and may thus complicate diagnosis. Rough attenuated mutants lack the O-polysaccharide and would solve this problem if eliciting protective immunity; the empirically o...

  4. What Effect Does International Migration Have on the Nutritional Status and Child Care Practices of Children Left Behind?

    Science.gov (United States)

    Jayatissa, Renuka; Wickramage, Kolitha

    2016-02-15

    Despite an increasing trend in labour migration and economic dependence on foreign migrant workers in Sri Lanka, very little is known about the child care and nutritional status of "children left behind". The aim of this study was to examine the factors influencing the nutritional status and care practices of children left behind. A sample of 321 children, 6-59 months old of international migrant workers from a cross-sectional nationally represented study were included. Care practices were assessed using ten caregiving behaviours on personal hygiene, feeding, and use of health services. Results revealed the prevalence of stunting, wasting and underweight to be 11.6, 18.2 and 24.0 percent, respectively. Father being a migrant worker has a positive effect on childcare practices and birthweight of the child. This study indicates that undernutrition remains a major concern, particularly in the poorest households where the mother is a migrant worker, also each additional 100 g increase in the birthweight of a child in a migrant household, decreases the probability of being wasted, stunted and underweight by 6%, 8% and 23% respectively. In depth study is needed to understand how labour migration affects household level outcomes related to child nutrition and childcare in order to build skills and capacities of migrant families.

  5. What Effect Does International Migration Have on the Nutritional Status and Child Care Practices of Children Left Behind?

    Directory of Open Access Journals (Sweden)

    Renuka Jayatissa

    2016-02-01

    Full Text Available Despite an increasing trend in labour migration and economic dependence on foreign migrant workers in Sri Lanka, very little is known about the child care and nutritional status of “children left behind”. The aim of this study was to examine the factors influencing the nutritional status and care practices of children left behind. A sample of 321 children, 6–59 months old of international migrant workers from a cross-sectional nationally represented study were included. Care practices were assessed using ten caregiving behaviours on personal hygiene, feeding, and use of health services. Results revealed the prevalence of stunting, wasting and underweight to be 11.6, 18.2 and 24.0 percent, respectively. Father being a migrant worker has a positive effect on childcare practices and birthweight of the child. This study indicates that undernutrition remains a major concern, particularly in the poorest households where the mother is a migrant worker, also each additional 100 g increase in the birthweight of a child in a migrant household, decreases the probability of being wasted, stunted and underweight by 6%, 8% and 23% respectively. In depth study is needed to understand how labour migration affects household level outcomes related to child nutrition and childcare in order to build skills and capacities of migrant families.

  6. What Effect Does International Migration Have on the Nutritional Status and Child Care Practices of Children Left Behind?

    Science.gov (United States)

    Jayatissa, Renuka; Wickramage, Kolitha

    2016-02-01

    Despite an increasing trend in labour migration and economic dependence on foreign migrant workers in Sri Lanka, very little is known about the child care and nutritional status of "children left behind". The aim of this study was to examine the factors influencing the nutritional status and care practices of children left behind. A sample of 321 children, 6-59 months old of international migrant workers from a cross-sectional nationally represented study were included. Care practices were assessed using ten caregiving behaviours on personal hygiene, feeding, and use of health services. Results revealed the prevalence of stunting, wasting and underweight to be 11.6, 18.2 and 24.0 percent, respectively. Father being a migrant worker has a positive effect on childcare practices and birthweight of the child. This study indicates that undernutrition remains a major concern, particularly in the poorest households where the mother is a migrant worker, also each additional 100 g increase in the birthweight of a child in a migrant household, decreases the probability of being wasted, stunted and underweight by 6%, 8% and 23% respectively. In depth study is needed to understand how labour migration affects household level outcomes related to child nutrition and childcare in order to build skills and capacities of migrant families. PMID:26891313

  7. The Relationship Between Child Maltreatment and Partner Violence Victimization and Perpetration Among College Students: Focus on Auditory Status and Gender.

    Science.gov (United States)

    McQuiller Williams, LaVerne; Porter, Judy L

    2015-08-01

    Partner violence is a pervasive public health concern that has received significant attention over the past three decades. Although a number of studies have reported that college students who are Deaf or hard of hearing are at an increased risk of experiencing partner violence compared with their hearing counterparts, little is known about partner violence perpetration among college students who are Deaf or hard of hearing. Furthermore, beyond disability, studies examining partner violence among students with disabilities tend to ignore other potential risk factors that may increase the risk of partner violence as a victim and/or a perpetrator. This exploratory study examines the extent of partner violence among male and female college students by auditory status and the relationship between experiencing and perpetrating partner abuse (i.e., physical abuse and psychological abuse) and child maltreatment (i.e., witnessing abuse and experiencing child physical abuse). The study also examines gender differences in the relationship between child maltreatment and physical and psychological abuse victimization and perpetration. Data were collected from a sample of approximately 680 college students at a northeastern university. Findings indicate that having witnessed interparental abuse as a child was only significant for being an adult victim of physical abuse. Having been a child victim of parental abuse was not significant for any of the abuse measures. Gender was only significant for being an adult victim of physical abuse. Deaf students were significantly more likely to report all abuse measures. Implications and directions for further research are discussed. PMID:25287415

  8. The Relationship Between Child Maltreatment and Partner Violence Victimization and Perpetration Among College Students: Focus on Auditory Status and Gender.

    Science.gov (United States)

    McQuiller Williams, LaVerne; Porter, Judy L

    2015-08-01

    Partner violence is a pervasive public health concern that has received significant attention over the past three decades. Although a number of studies have reported that college students who are Deaf or hard of hearing are at an increased risk of experiencing partner violence compared with their hearing counterparts, little is known about partner violence perpetration among college students who are Deaf or hard of hearing. Furthermore, beyond disability, studies examining partner violence among students with disabilities tend to ignore other potential risk factors that may increase the risk of partner violence as a victim and/or a perpetrator. This exploratory study examines the extent of partner violence among male and female college students by auditory status and the relationship between experiencing and perpetrating partner abuse (i.e., physical abuse and psychological abuse) and child maltreatment (i.e., witnessing abuse and experiencing child physical abuse). The study also examines gender differences in the relationship between child maltreatment and physical and psychological abuse victimization and perpetration. Data were collected from a sample of approximately 680 college students at a northeastern university. Findings indicate that having witnessed interparental abuse as a child was only significant for being an adult victim of physical abuse. Having been a child victim of parental abuse was not significant for any of the abuse measures. Gender was only significant for being an adult victim of physical abuse. Deaf students were significantly more likely to report all abuse measures. Implications and directions for further research are discussed.

  9. Effect of vitamin A supplementation with BCG vaccine at birth on vitamin A status at 6 wk and 4 mo of age

    DEFF Research Database (Denmark)

    Fisker, Ane B; Lisse, Ida M; Aaby, Peter;

    2007-01-01

    with higher (9%; 95% CI: 2, 17%) RBP concentrations in children of noneducated mothers but not in children of educated mothers. Overall, RBP concentrations increased between 6 wk and 4 mo of age. The increase correlated inversely with the number of diphtheria-tetanus-pertussis (DTP) vaccines received......BACKGROUND: The effect of vitamin A supplementation (VAS) at birth on subsequent vitamin A status has not been studied. OBJECTIVE: The objective was to study the effect of 50,000 IU vitamin A administered with BCG vaccine at birth on vitamin A status in both sexes. DESIGN: Within a randomized...... A recipients, subsequent DTP vaccines affected vitamin A status negatively. The main trial was registered at clinicaltrials.gov as NCT00168597....

  10. Effect of vitamin A supplementation with BCG vaccine at birth on vitamin A status at 6 wk and 4 mo of age

    DEFF Research Database (Denmark)

    Fisker, Ane B; Lisse, Ida M; Aaby, Peter;

    2007-01-01

    with higher (9%; 95% CI: 2, 17%) RBP concentrations in children of noneducated mothers but not in children of educated mothers. Overall, RBP concentrations increased between 6 wk and 4 mo of age. The increase correlated inversely with the number of diphtheria-tetanus-pertussis (DTP) vaccines received......BACKGROUND: The effect of vitamin A supplementation (VAS) at birth on subsequent vitamin A status has not been studied. OBJECTIVE: The objective was to study the effect of 50,000 IU vitamin A administered with BCG vaccine at birth on vitamin A status in both sexes. DESIGN: Within a randomized...... A recipients, subsequent DTP vaccines affected vitamin A status negatively. The main trial was registered at clinicaltrials.gov as NCT00168597. Udgivelsesdato: 2007-Oct...

  11. Higher weight status of only and last-born children. Maternal feeding and child eating behaviors as underlying processes among 4-8 year olds.

    Science.gov (United States)

    Mosli, Rana H; Lumeng, Julie C; Kaciroti, Niko; Peterson, Karen E; Rosenblum, Katherine; Baylin, Ana; Miller, Alison L

    2015-09-01

    Birth order has been associated with childhood obesity. The objective of this cross-sectional study was to examine maternal feeding and child eating behaviors as underlying processes for increased weight status of only children and youngest siblings. Participants included 274 low-income 4-8 year old children and their mothers. The dyads completed a videotaped laboratory mealtime observation. Mothers completed the Caregiver's Feeding Styles Questionnaire and the Children's Eating Behavior Questionnaire. Child weight and height were measured using standardized procedures. Path analysis was used to examine associations of birth order, maternal feeding behavior, child eating behavior, and child overweight/obese status. The association between only child status and greater likelihood of overweight/obesity was fully mediated by higher maternal Verbal Discouragement to eat and lower maternal Praise (all p values youngest sibling status and greater likelihood of overweight/obesity was partially mediated by lower maternal Praise and lower child Food Fussiness (all p values < 0.05). Results provide support for our hypothesis that maternal control and support and child food acceptance are underlying pathways for the association between birth order and weight status. Future findings can help inform family-based programs by guiding family counseling and tailoring of recommendations for family mealtime interactions. PMID:26009204

  12. Child Care Choices, Food Choices, and Children’s Obesity Status

    OpenAIRE

    Mandal, Bidisha; Powell, Lisa M.

    2013-01-01

    We evaluate the effect of differences in child care and food environments on obesity among children in the age group of four to six years. To address non-random selection of children into different child care settings, we first predict market price of child care and market wages, and then examine how these affect choice of child care settings and the amount of time children spend in different settings. Using panel data models, we analyze the role of care settings on frequency of consumption o...

  13. Evaluation of Child Self-perception Regarding Their Oro-dental Status

    Directory of Open Access Journals (Sweden)

    Krisztina Mártha I.

    2013-10-01

    Full Text Available Aim: The aim of this study was to evaluate the state of oral health and the self-perception of children regarding their oro-dental status, their knowledge and attitude towards oral health. Methods: A sample of 130 children (11-14 years and one of their parents were asked to complete a Child Perception Questionnaire (CPQ11-14 in Sfântu Gheorghe, Romania. From these, 69 children were examined and data was recorded about Decayed-Missing-Filled Teeth (DMFT, oral hygiene, dental malposition and malocclusion, Aesthetic Component of Index of Treatment Need (AC-IOTN. Consent of the parents was obtained. Statistical analyses were performed. Results: The optimal score of CPQ evaluation is 96 and the maximum score achieved was 93, the minimum was 43. 78.10 average score can be graded as medium. As the data points out, most of the children and their parents have a medium knowledge and self-perception. The clinical examination underline the main problems: dental caries (62%, occlusal coloration (23%, dental malposition (17%, rooftop deep bite (14%, dental rotation and crowding (12%, dental plaque and tartar (10%. As far as the AC-IOTN is concerned, 48 of 69 children have no need for treatment, 18 have a high need for treatment, and 3 have a moderate need for treatment. Conclusions: Overall, the children and their parents have a poor oral health knowledge, which is reflected in the medium level of the achieved CPQ scores, in the clinical examination and can be associated with high levels of dental caries and malocclusion

  14. Current status and prospects for development of a vaccine against Trichomonas vaginalis infections.

    Science.gov (United States)

    Smith, Jeffrey; Garber, Gary E

    2014-03-20

    Trichomonas vaginalis is a sexually transmitted pathogen with an annual worldwide incidence of over 276 million infections, the highest of all curable and non-viral STI. A large proportion of cases are asymptomatic and under-diagnosed with conventional diagnostic tools. Infection has important maternal and fetal health consequences and can lead to a higher probability of HIV transmission and susceptibility. Lack of affordable accurate diagnostic tests globally and metronidazole resistance hinder T. vaginalis control efforts. Based on data from current vaccination studies in animal models, a human vaccine is achievable to intervene on the substantial incidence of infection.

  15. Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh

    Science.gov (United States)

    Purpose Poor vitamin B12 (B12) status is associated with adverse outcomes in pregnancy and infancy. Little is known about effects of B12 supplementation on immune function. The present study aimed to evaluate effects of pre- and postnatal B12 supplementation on biomarkers of B12 status and vaccine-s...

  16. Physician Attitudes and Beliefs Associated with Patient Pneumococcal Polysaccharide Vaccination Status

    OpenAIRE

    Santibanez, Tammy A.; Zimmerman, Richard Kent; Nowalk, Mary Patricia; Katz Jewell, Ilene; Bardella, Inis J.

    2004-01-01

    BACKGROUND Barriers to adult immunizations persist as current rates for pneumococcal polysaccharide vaccine (PPV) receipt among eligible adults remain below national goals. This study investigated potential barriers to patients receiving the PPV, including predisposing, enabling, environmental and reinforcing factors among physicians from a variety of practice and geographic settings.

  17. Vaccination against foot-and-mouth disease II: regaining FMD-free status

    NARCIS (Netherlands)

    Backer, J.A.; Engel, B.; Dekker, A.; Roermund, van H.J.W.

    2012-01-01

    An epidemic of foot-and-mouth disease (FMD) can have devastating effects on animal welfare, economic revenues, the export position and society as a whole. The preferred control strategy in the Netherlands has recently changed to vaccination-to-live, but – not have been applied before – this poses un

  18. Child dental anxiety, parental rearing style and referral status of children

    NARCIS (Netherlands)

    J.B. Krikken; A.J. van Wijk; J.M. ten Cate; J.S.J. Veerkamp

    2012-01-01

    Objective: Treating children can be difficult for both dentist and child. In some cases treatment fails and those children are referred to a specialist paediatric dentist. Different factors can be put forward for referral of children, such as factors relating to the child, dentist and parent. Possib

  19. Status Report on Publicly Traded Child Care Companies--An Interview with John McLaughlin.

    Science.gov (United States)

    Neugebauer, Roger

    1997-01-01

    Interview with editor of "Education Industry Report" reveals why child care companies choose to go public on stock exchanges and how publicly traded child care companies are faring. Discusses potential for growth in the industry, advantages of private placement, and recommended steps for going public. Describes nine publicly traded companies. (KB)

  20. The Economic Impact of Child Support Reform on the Poverty Status of Custodial and Noncustodial Families.

    Science.gov (United States)

    Nichols-Casebolt, Ann

    1986-01-01

    Used data from the Michigan Panel Study of Income Dynamics to examine the economic impact of child support reform on affected families. Results revealed that, compared to the current child support system, the proposed alternative would reduce poverty for custodial families but would increase poverty for noncustodial families. (Author/NB)

  1. Socioeconomic status and child mental health: the role of parental emotional well-being and parenting practices.

    Science.gov (United States)

    Bøe, Tormod; Sivertsen, Børge; Heiervang, Einar; Goodman, Robert; Lundervold, Astri J; Hysing, Mari

    2014-01-01

    This study examined the role of parental emotional well-being and parenting practices as mediators of the association between familial socioeconomic status (SES) and child mental health problems. The sample included 2,043 5th-7th graders (50.7 % female) participating in the second wave of the Bergen Child Study. Children completed the Strengths and Difficulties Questionnaire, parents reported family economy and education level, emotional well-being (measured with the Everyday Feelings Questionnaire), and the use of negative disciplinary and affirmative parenting practices (measured using the Family Life Questionnaire). Path analyses were conducted to examine the associations between SES and externalizing and internalizing problems. Results supported a model where family economy was associated with externalizing problems through parental emotional well-being and parenting practices, whereas maternal education level was associated with externalizing problems through negative discipline. The direct association between paternal education level and externalizing problems was not mediated by parenting. For internalizing problems, we found both direct associations with family economy and indirect associations with family economy through parental emotional well-being and parenting. The results suggest that parental emotional well-being and parenting practices are two potential mechanisms through which low socioeconomic status is associated with child mental health problems.

  2. Current status and prospects of the persecution of child recruiters: the Colombian case

    Directory of Open Access Journals (Sweden)

    Ana María Caballero Acevedo

    2015-10-01

    Full Text Available The purpose of this work is to acknowledge the dispositions that would be applicable to the perpetrators of child recruitment in the Colombian armed conflict, observing (i the dynamics of child recruitment in the country, (ii the international law, (iii the national law, and (iv relevant global trends. On the basis of documentary work, it was found that the nature of the crime of child recruitment, the growing global demands on its punishment and the adoption of tough dispositions in the national legislation, clear the way for the prosecution of perpetrators. Other remarked findings are these two identified trends: (i both in the national and the international scenes, it is widely accepted that the age of 18 (opposed to the 15 years old previous disposition is the minimum for being protected against child recruitment; and (ii amnesties granted within transitional justice processes are increasingly and decidedly excluding serious crimes, like child recruitment.

  3. IMMUNE STATUS OF CHILDREN TWO MONTHS TO SIX YEARS OLD TO POLIOVIRUSES I, II AND III INA RURAL AREA OF TEHRAN RELATED TO HISTORY OF VACCINATION

    Directory of Open Access Journals (Sweden)

    N. Sabouri

    1987-12-01

    Full Text Available A serum survey was conducted to determine the immune status of children 2 months to 6 Years old to polio virus type I, II and III related to the history of oral polio vaccination in Fashapouye (A rural area in the south of Teheran. 566 serum samples were obtained from children in 9 different villages and microneutra lization test was performed on 1;10 dilution of these sera. The study revealed that 62 per cent had received three or more doses of vaccine, 8.3 per cent two doses, 13 per cent one dose 5.6 per cent were not vaccinated. On the entire study group prevalence of immunity (serum titer 1; 10 irrespective to the history of vaccination was 90, 94 and 86 per cent for polio I, II and III respectively. The highest rate of unvaccinated and nonimmune children was in 2 to 6 months old group. The percentage of children lacking antibody to polio, I, II and III in nonvaccinated is 41, 25 and 34 percent respectively and these rates decrease in vaccinated children to reach the level of 6, 2 and 10 percent in those who have received three or more doses of vaccine. Over all results suggest that an adequate response to oral polio vaccination is observed in this rural region but an increased effort must be made for covering a higher percentage of children in all age groups especially in 2 months to one year old.

  4. Current Status and Development of Vaccines and Other Biologics for Human Rabies Prevention.

    Science.gov (United States)

    Rupprecht, Charles E; Nagarajan, Thirumeni; Ertl, Hildegund

    2016-06-01

    Rabies is a neglected viral zoonosis with the highest case fatality of any infectious disease. Pasteur's historical accomplishments during the late 19(th) century began the process of human vaccine development, continuing to evolve into the 21(st) century. Over the past 35 years, great improvements occurred in the production of potent tissue culture vaccines and the gradual removal from the market of unsafe nerve tissue products. Timely and appropriate administration of modern biologics virtually assures survivorship, even after severe exposures. Nevertheless, in the developing world, if not provided for free nationally, the cost of a single course of human prophylaxis exceeds the average monthly wage of the common worker. Beyond traditional approaches, recombinant, sub-unit and other novel methods are underway to improve the availability of safe, effective and more affordable rabies biologics.

  5. Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed.

    Science.gov (United States)

    Fuche, Fabien J; Sow, Ousmane; Simon, Raphael; Tennant, Sharon M

    2016-09-01

    Nontyphoidal Salmonella (NTS; i.e., Salmonella enterica organisms that do not cause typhoid or paratyphoid) are responsible for 94 million infections and 155,000 deaths worldwide annually, 86% of which are estimated to be foodborne. Although more than 50 serogroups and 2,600 serovars have been described, not all Salmonella serovars cause disease in humans and animals. Efforts are being made to develop NTS vaccines, with most approaches eliciting protection against serovars Typhimurium and Enteritidis (serogroups B [O:4] and D [O:9], respectively), as they are widely considered the most prevalent. Here, we show that serogroup C (O:6,7, O:6,8, or O:8 epitopes) is the most common serogroup in the United States, and the prevalence of serovars from this serogroup has been increasing in Europe and the United States over the last decade. They are also the most commonly isolated serovars from healthy cattle and poultry, indicating the underlying importance of surveillance in animals. Four out of the 10 most lethal serovars in the United States are serogroup C, and reports from African countries suggest that strains within this serogroup are highly antibiotic resistant. Serogroup C consists of highly diverse organisms among which 37 serovars account for the majority of human cases, compared to 17 and 11 serovars for serogroups B and D, respectively. Despite these concerning data, no human vaccines targeting serogroup C NTS are available, and animal vaccines are in limited use. Here, we describe the underestimated burden represented by serogroup C NTS, as well as a discussion of vaccines that target these pathogens. PMID:27413069

  6. Protective status of end-stage renal disease children against tetanus and diphtheria vaccination

    Directory of Open Access Journals (Sweden)

    Mohammadreza Modarresi

    2013-01-01

    Methods: This cross-sectional study was carried on 83 participants less than 18 years including 27 patients on hemodialysis or peritoneal dialysis and 56 normal populations from February 2008 until December 2008 at St. Alzahra hospital, Isfahan, Iran. To determine anti-tetanus and anti-diphtheria antibodies level, Tetanus IgG ELISA kit (IBL International, Germany, RE56901 and Diphtheria IgG ELISA kit (IBL International, Germany, RE56191 were used. The participants must not received immunoglobulin, blood products or immunosuppressive medication in the current 6 months. Results: The mean age of case and control group were 12.5 ± 2.7 years and 11.7 ± 3.3 years, respectively, P > 0.05. According to IgG levels, 93% of hemodialysis patients and approximately 87% of peritoneal dialysis children needed booster doses of diphtheria vaccination. The results for IgG titer against tetanus revealed that in 91% of hemodialysis patients and 83% of peritoneal dialysis children booster doses of tetanus were recommended. Conclusions: Booster doses of vaccines may be required in ESRD children. Measuring serum IgG levels against vaccines to define protective levels are recommended.

  7. Association of Maternal and Child Health Center (Posyandu Availability with Child Weight Status in Indonesia: A National Study

    Directory of Open Access Journals (Sweden)

    Helen Andriani

    2016-03-01

    Full Text Available Little is known about the childhood obesity prevention and treatment practices of Maternal and Child Health services (Posyandu in Indonesia or in other countries. The present study aims to assess the association of the availability of Posyandu with overweight and obesity in children of different household wealth levels. This was a secondary analysis of data collected in the 2013 Riskesdas (or Basic Health Research survey, a cross-sectional study, representative population-based data. Height and weight, the availability of Posyandu, and basic characteristics of the study population were collected from parents with children aged 0 to 5 years (n = 63,237. Non-availability of Posyandu significantly raised the odds of being obese (OR = 1.13, 95% CI: 1.06–1.21 and did not show a significant relationship in the odds for overweight (OR = 0.99, 95% CI: 0.93–1.07. This relationship persisted after a full adjustment (OR = 1.16, 95% CI: 1.07–1.25 and OR = 1.04, 95% CI: 0.96–1.13, respectively. There was effect modification by household wealth, which was stronger for obese children. The availability of Posyandu has a protective association with childhood obesity in Indonesia. Posyandu services are well placed to play an important role in obesity prevention and treatment in early life.

  8. Good Child is a Calm Child: Mothers' Social Status, Maternal Conceptions of Proper Demeanor, and Stranger Anxiety in One-Year Old Cameroonian Nso Children

    Directory of Open Access Journals (Sweden)

    Hiltrud Otto

    2015-04-01

    Full Text Available Our article questions the assumption that stranger anxiety develops universally in children; thereby our study is rooted in a long tradition in psychological anthropology of testing the universality of theories formulated in Western society. We argue that the infant's behavior towards strangers is the product of socialization processes that represent adaptations to cultural contexts. Our study investigates the ethnotheory of childrearing and the development of stranger anxiety in a Cameroonian community of traditional Nso farmers. The participants of the study were 29 Cameroonian Nso mothers with one-year old children. Using a multi-method approach, we demonstrate that Nso mothers value inexpressive infants that adjust easily to others. Accordingly, a considerably large number of one-year old Nso infants showed no stranger anxiety when encountered by a stranger. Maternal social status and her social support system proved crucial to successful implementation of the socialization goal of a calm child. Our data support the view that child behavior is a product of culturally constructed experiences of daily life. The acknowledgement of the cultural construction of stranger anxiety carries implications for developmental theories, especially for attachment theory, which relies on the universality of stranger anxiety in their most acclaimed paradigm, the Strange Situation.

  9. Childhood vaccination in informal urban settlements in Nairobi, Kenya: Who gets vaccinated?

    Directory of Open Access Journals (Sweden)

    Ettarh Remare R

    2011-01-01

    Full Text Available Abstract Background Recent trends in global vaccination coverage have shown increases with most countries reaching 90% DTP3 coverage in 2008, although pockets of undervaccination continue to persist in parts of sub-Saharan Africa particularly in the urban slums. The objectives of this study were to determine the vaccination status of children aged between 12-23 months living in two slums of Nairobi and to identify the risk factors associated with incomplete vaccination. Methods The study was carried out as part of a longitudinal Maternal and Child Health study undertaken in Korogocho and Viwandani slums of Nairobi. These slums host the Nairobi Urban Health and Demographic Surveillance System (NUHDSS run by the African Population and Health Research Centre (APHRC. All women from the NUHDSS area who gave birth since September 2006 were enrolled in the project and administered a questionnaire which asked about the vaccination history of their children. For the purpose of this study, we used data from 1848 children aged 12-23 months who were expected to have received all the WHO-recommended vaccinations. The vaccination details were collected during the first visit about four months after birth with follow-up visits repeated thereafter at four month intervals. Full vaccination was defined as receiving all the basic childhood vaccinations by the end of 24 months of life, whereas up-to-date (UTD vaccination referred to receipt of BCG, OPV 1-3, DTP 1-3, and measles vaccinations within the first 12 months of life. All vaccination data were obtained from vaccination cards which were sighted during the household visit as well as by recall from mothers. Multivariate models were used to identify the risk factors associated with incomplete vaccination. Results Measles coverage was substantially lower than that for the other vaccines when determined using only vaccination cards or in addition to maternal recall. Up-to-date (UTD coverage with all vaccinations

  10. Weight status and gender-related differences in motor skills and in child care - based physical activity in young children

    Directory of Open Access Journals (Sweden)

    Bonvin Antoine

    2012-03-01

    Full Text Available Abstract Background Over the last decades, a decline in motor skills and in physical activity and an increase in obesity has been observed in children. However, there is a lack of data in young children. We tested if differences in motor skills and in physical activity according to weight or gender were already present in 2- to 4-year-old children. Methods Fifty-eight child care centers in the French part of Switzerland were randomly selected for the Youp'là bouge study. Motor skills were assessed by an obstacle course including 5 motor skills, derived from the Zurich Neuromotor Assessment test. Physical activity was measured with accelerometers (GT1M, Actigraph, Florida, USA using age-adapted cut-offs. Weight status was assessed using the International Obesity Task Force criteria (healthy weight vs overweight for body mass index (BMI. Results Of the 529 children (49% girls, 3.4 ± 0.6 years, BMI 16.2 ± 1.2 kg/m2, 13% were overweight. There were no significant weight status-related differences in the single skills of the obstacle course, but there was a trend (p = 0.059 for a lower performance of overweight children in the overall motor skills score. No significant weight status-related differences in child care-based physical activity were observed. No gender-related differences were found in the overall motor skills score, but boys performed better than girls in 2 of the 5 motor skills (p ≤ 0.04. Total physical activity as well as time spent in moderate-vigorous and in vigorous activity during child care were 12-25% higher and sedentary activity 5% lower in boys compared to girls (all p Conclusions At this early age, there were no significant weight status- or gender-related differences in global motor skills. However, in accordance to data in older children, child care-based physical activity was higher in boys compared to girls. These results are important to consider when establishing physical activity recommendations or targeting

  11. Public acceptance and willingness to hepatitis a vaccination in children aged 7-18 years in Republic of Korea.

    Science.gov (United States)

    Kong, Kyoung Ae; Yoon, Seo Hee; Cho, Su Jin; Kim, Han Wool; Kim, Kyung-Hyo

    2014-11-01

    Hepatitis A can cause serious illness among adolescents and adults with low vaccination coverage. Even though hepatitis A vaccine is one of the strong candidates for Korean national immunization program, adolescents aged older than 12 yr would not benefit. Our purpose was to assess the willingness and analyze the correlates of Korean mothers for hepatitis A (HepA) vaccination to develop strategies for HepA vaccination. A national telephone survey on 800 mothers with children aged 7-18 yr was conducted with random-digit dialing method. Sixty-two percent and 92% of the mothers reported that they were willing to HepA vaccination at current cost and at half of the current cost, respectively. However, at current cost, only 79% wished to vaccinate their child in an epidemic and 32% wished to vaccinate promptly. Having two or more children, not having future plans to send the child overseas, and low family income were significantly associated with not willing to HepA vaccination. Low perception of the susceptibility for hepatitis A and perception of the current cost as barrier increased the odds of unwillingness to vaccination at current cost and to prompt vaccination. The mothers' willingness to HepA vaccination for the children aged 7-18 yr in Korea was not very high at current cost and associated socioeconomic status and health-belief. Targeted intervention or strategies are needed to increase the HepA vaccination rate among children in Korea.

  12. Looking upstream: enhancers of child nutritional status in post-flood rural settings.

    Science.gov (United States)

    Rodriguez-Llanes, Jose Manuel; Ranjan-Dash, Shishir; Mukhopadhyay, Alok; Guha-Sapir, Debarati

    2016-01-01

    Background. Child undernutrition and flooding are highly prevalent public health issues in many developing countries, yet we have little understanding of preventive strategies for effective coping in these circumstances. Education has been recently highlighted as key to reduce the societal impacts of extreme weather events under climate change, but there is a lack of studies assessing to what extent parental education may prevent post-flood child undernutrition. Methods and Materials. One year after large floods in 2008, we conducted a two-stage cluster population-based survey of 6-59 months children inhabiting flooded and non-flooded communities of Jagatsinghpur district, Odisha (India), and collected anthropometric measurements on children along with child, parental and household level variables through face-to-face interviews. Using multivariate logistic regression models, we examined separately the effect of maternal and paternal education and other risk factors (mainly income, socio-demographic, and child and mother variables) on stunting and wasting in children from households inhabiting recurrently flooded communities (2006 and 2008; n = 299). As a comparison, separate analyses on children in non-flooded communities were carried out (n = 385). All analyses were adjusted by income as additional robustness check. Results. Overall, fathers with at least completed middle education (up to 14 years of age and compulsory in India) had an advantage in protecting their children from child wasting and stunting. For child stunting, the clearest result was a 100-200% lower prevalence associated with at least paternal secondary schooling (compared to no schooling) in flooded-areas. Again, only in flooded communities, an increase in per capita annual household income of 1,000 rupees was associated to a 4.7-4.9% lower prevalence of child stunting. For child wasting in flooded areas, delayed motherhood was associated to better nutritional outcomes (3.4% lower prevalence per

  13. Determinants of vaccination coverage in rural Nigeria

    Directory of Open Access Journals (Sweden)

    Meurice Francois P

    2008-11-01

    Full Text Available Abstract Background Childhood immunization is a cost effective public health strategy. Expanded Programme on Immunisation (EPI services have been provided in a rural Nigerian community (Sabongidda-Ora, Edo State at no cost to the community since 1998 through a privately financed vaccination project (private public partnership. The objective of this survey was to assess vaccination coverage and its determinants in this rural community in Nigeria Methods A cross-sectional survey was conducted in September 2006, which included the use of interviewer-administered questionnaire to assess knowledge of mothers of children aged 12–23 months and vaccination coverage. Survey participants were selected following the World Health Organization's (WHO immunization coverage cluster survey design. Vaccination coverage was assessed by vaccination card and maternal history. A child was said to be fully immunized if he or she had received all of the following vaccines: a dose of Bacille Calmette Guerin (BCG, three doses of oral polio (OPV, three doses of diphtheria, pertussis and tetanus (DPT, three doses of hepatitis B (HB and one dose of measles by the time he or she was enrolled in the survey, i.e. between the ages of 12–23 months. Knowledge of the mothers was graded as satisfactory if mothers had at least a score of 3 out of a maximum of 5 points. Logistic regression was performed to identify determinants of full immunization status. Results Three hundred and thirty-nine mothers and 339 children (each mother had one eligible child were included in the survey. Most of the mothers (99.1% had very positive attitudes to immunization and > 55% were generally knowledgeable about symptoms of vaccine preventable diseases except for difficulty in breathing (as symptom of diphtheria. Two hundred and ninety-five mothers (87.0% had a satisfactory level of knowledge. Vaccination coverage against all the seven childhood vaccine preventable diseases was 61.9% although it

  14. Your child's first vaccines

    Science.gov (United States)

    ... younger than 3 months of age. 4. Hib (Haemophilus influenzae type b) Signs and symptoms can include fever, headache, stiff ... be recommended for travel to certain countries. Hib ( Haemophilus influenzae type b) 3 or 4 2 months, 4 months, (6 ...

  15. Conflict Competence of Preschool Children and its Relationship with the Sociometric Status of the Child in the Peer Group

    Directory of Open Access Journals (Sweden)

    Denisenkova N.S.,

    2015-02-01

    Full Text Available The purpose of the study was to investigate the conflict competence of children of preschool age and identification of its relationship with the child's sociometric status in the peer group. The hypothesis of the study was that there is a relationship between the sociometric status of preschoolers in the peer group and the strategy of their behavior in a conflict situation, a conflict of competence. The study involved children (41 children: 22 boys and 19 girls aged 5-7 years, attending preparatory groups in kindergartens in Moscow (in 2011-2013. The study was conducted using an experimental technique "Desk of cooperation" (M. Madsen, aimed at the study of conflict competence, the sociometric technique "Two Houses" (modification by R.I. Govorova, and a survey of educators aimed at identifying the status position in the preschool group peers. According to the survey, we can say that there are qualitative differences in the strategies of behavior in the conflict that children with different sociometric status choose.

  16. Predicted vitamin D status in mid-pregnancy and child allergic disease

    DEFF Research Database (Denmark)

    Maslova, Ekaterina; Hansen, Susanne; Thorne-Lyman, Andrew L;

    2014-01-01

    BACKGROUND: Vitamin D deficiency in pregnancy may be a risk factor for child allergic disease. However, less is known about disease risk across different levels of vitamin D. OBJECTIVE: We aimed to examine the relation between a maternal vitamin D prediction score and child allergic disease....... METHODS: A total of 32,456 pregnant women were enrolled in the Danish National Birth Cohort (1996-2003) and had data on a validated vitamin D prediction score based on 1497 mid-pregnancy plasma 25(OH)D samples. Child allergic disease was assessed at 18 months and at 7 years using questionnaire data...... prediction score examined in quintiles or by restricted categories (≥75 nmol/l and asthma at 18 months (RR: 1.36, 95% CI: 1...

  17. Only-Child Status in Relation to Perceived Stress and Studying-Related Life Satisfaction among University Students in China: A Comparison with International Students

    OpenAIRE

    Janet Junqing Chu; Mobarak Hossain Khan; Jahn, Heiko J.; Alexander Kraemer

    2015-01-01

    Objectives University students in general face multiple challenges, which may affect their levels of perceived stress and life satisfaction. Chinese students currently face specific strains due to the One-Child Policy (OCP). The aim of this study was to assess (1) whether the levels of perceived stress and studying-related life satisfaction are associated with only-child (OC) status after controlling for demographic and socio-economic characteristics and (2) whether these associations differ ...

  18. Child Mortality as Predicted by Nutritional Status and Recent Weight Velocity in Children under Two in Rural Africa.

    LENUS (Irish Health Repository)

    2012-01-31

    WHO has released prescriptive child growth standards for, among others, BMI-for-age (BMI-FA), mid-upper arm circumference-for-age, and weight velocity. The ability of these indices to predict child mortality remains understudied, although growth velocity prognostic value underlies current growth monitoring programs. The study aims were first to assess, in children under 2, the independent and combined ability of these indices and of stunting to predict all-cause mortality within 3 mo, and second, the comparative abilities of weight-for-length (WFL) and BMI-FA to predict short-term (<3 mo) mortality. We used anthropometry and survival data from 2402 children aged between 0 and 24 mo in a rural area of the Democratic Republic of Congo with high malnutrition and mortality rates and limited nutritional rehabilitation. Analyses used Cox proportional hazard models and receiver operating characteristic curves. Univariate analysis and age-adjusted analysis showed predictive ability of all indices. Multivariate analysis without age adjustment showed that only very low weight velocity [HR = 3.82 (95%CI = 1.91, 7.63); P < 0.001] was independently predictive. With age adjustment, very low weight velocity [HR = 3.61 (95%CI = 1.80, 7.25); P < 0.001] was again solely retained as an independent predictor. There was no evidence for a difference in predictive ability between WFL and BMI-FA. This paper shows the value of attained BMI-FA, a marker of wasting status, and recent weight velocity, a marker of the wasting process, in predicting child death using the WHO child growth standards. WFL and BMI-FA appear equivalent as predictors.

  19. Indian Child Welfare: A Status Report. Final Report of the Survey of Indian Child Welfare and Implementation of the Indian Child Welfare Act and Section 428 of the Adoption Assistance and Child Welfare Act of 1980.

    Science.gov (United States)

    Plantz, Margaret C.; And Others

    This is a report on the first national examination of the effects of the Indian Child Welfare Act (Public Law 95-608), enacted in 1978. The study examines the prevalence of Native American children in substitute care and the implementation of the act and portions of the Adoption Assistance and Child Welfare Act of 1980 as they affect Indian…

  20. The Role of Parenting Styles and Socio-Economic Status in Parents' Knowledge of Child Development

    Science.gov (United States)

    September, Shiron Jade; Rich, Edna Grace; Roman, Nicolette Vanessa

    2016-01-01

    Early childhood development (ECD) has been recognised to be the most important contributor to long-term social and emotional development. Therefore, positive parenting is paramount to foster quality parent-child interaction. Previous research shows that for parents to adopt a positive parenting style, some degree of parental knowledge is required.…

  1. Child Nutritional Status in Poor Ethiopian Households: The role of gender, assets and location

    NARCIS (Netherlands)

    Mekonnen, A.; Bezuayehu, T.O.; Woldehanna, T.; Jones, N.; Seager, J.; Alemu, T.; Asgedom, G.

    2005-01-01

    As one of the poorest countries in the world, Ethiopia¿s rate of child malnutrition is one of the highest, even within sub¿Saharan Africa. The causes and relative importance of various determinants of malnutrition in Ethiopia are not well understood. This paper specifically explores some of the less

  2. The quality of reporting and publication status of vaccines trials presented at veterinary conferences from 1988 to 2003.

    Science.gov (United States)

    Brace, Samantha; Taylor, Dan; O'Connor, Annette M

    2010-07-19

    Conference proceedings, although an importance source to learn about new interventions, are brief and not subject to external evaluation prior to publication. Studies in human medicine suggest that trial results from conference proceedings may be poorly reported. The primary objective of this study was to evaluate characteristics of veterinary vaccine studies published in conference proceedings. 154 cattle or swine vaccine trials presented at veterinary practitioner conferences held in the United States from 1988 to 2003 were the test base to evaluate the following: abstract-to-publication ratio, positive-outcome ratios, differences between proceeding and subsequent journal articles, and compliance with the CONSORT Statement extension for abstracts. The abstract-to-publication ratio was 5/89 for swine trials and 6/65 for cattle trials. The positive-outcome ratio for swine conference proceeding and journal articles was 57/89 and 4/5 respectively. The positive-outcome ratio for bovine conference proceeding and journal articles was 34/65 and 4/6 respectively. No major differences were found between conference proceedings and matching journal articles. Fewer than 10% of conference proceedings included: identification of the trials as randomized in the title, study design as field or challenge; the primary outcome; trial status; results for primary outcome; information about harms and funding source (2/89). When conference proceedings are subsequently published in journals; there is no significant difference in the data, however subsequent publication is uncommon. For many conference proceedings it would be difficult to assess the internal and external validity of the trial based on the information reported.

  3. Vaccination Perceptions and Barriers of School Employees: A Pilot Study

    Science.gov (United States)

    Luthy, Karlen E.; Houle, Kim; Beckstrand, Renea L.; Macintosh, Janelle; Lakin, Richard G.

    2013-01-01

    Schools are where vaccine-preventable diseases can spread. Vaccination of school children has been studied; however, data are lacking on the vaccination status, perceptions, and barriers to vaccination for school employees. We surveyed school employees' vaccination perceptions, awareness of current vaccination status, and potential barriers…

  4. Vitamin D status among immigrant mothers from Pakistan, Turkey and Somalia and their infants attending child health clinics in Norway.

    Science.gov (United States)

    Madar, Ahmed A; Stene, Lars C; Meyer, Haakon E

    2009-04-01

    High prevalences of vitamin D deficiency have been reported in non-Western immigrants moving to Western countries, including Norway, but there is limited information on vitamin D status in infants born to immigrant mothers. We aimed to describe the vitamin D status and potentially correlated factors among infants aged 6 weeks and their mothers with Pakistani, Turkish or Somali background attending child health clinics in Norway. Eighty-six healthy infants and their mothers with immigrant background were recruited at the routine 6-week check-up at nine centres between 2004 and 2006. Venous or capillary blood was collected at the clinics from the mother and infant, and serum separated for analysis of 25-hydroxyvitamin D (s-25(OH)D) and intact parathyroid hormone (s-iPTH). The mean maternal s-25(OH)D was 25.8 nmol/l, with 57 % below 25 nmol/l and 15 % below 12.5 nmol/l. Of the mothers, 26 % had s-iPTH>5.7 pmol/l. For infants, mean s-25(OH)D was 41.7 nmol/l, with 47 % below 25 nmol/l and 34 % below 12.5 nmol/l. s-25(OH)D was considerably lower in the thirty-one exclusively breast-fed infants (mean 11.1 nmol/l; P < 0.0001). Use of vitamin D supplements and education showed a positive association with maternal s-25(OH)D. There was no significant association between mother's and child's s-25(OH)D, and no significant ethnic or seasonal variation in s-25(OH)D for mothers or infants. In conclusion, there is widespread vitamin D deficiency in immigrant mothers and their infants living in Norway. Exclusively breast-fed infants who did not receive vitamin D supplements had particularly severe vitamin D deficiency.

  5. Age-appropriate feeding practices and nutritional status of infants attending child welfare clinic at a Teaching Hospital in Nigeria

    Directory of Open Access Journals (Sweden)

    Umar M Lawan

    2014-01-01

    Full Text Available Background: Appropriate infant feeding is the key to optimum infant and child development and survival. This study investigates age-appropriate infant feeding practices and nutritional status of infants attending the immunization and child welfare clinic at Aminu Kano Teaching Hospital. Materials and Methods: Using a cross-sectional descriptive design, a sample of 300 sets of infants (age ≤12 months and caregivers was systematically selected and studied. The data were analyzed using the MINITAB ® 12.21 (USA statistical software. Results: All the infants studied were still on breast milk. Most of the mothers demonstrated correct body positioning (89.9 and attachment (78.7% during breastfeeding, and effective suckling was demonstrated in 77.0%. Interestingly, none of the infants was either exclusively breastfed for 6 months or currently on exclusive breastfeeding. Furthermore, only 64 (58.2% of the 110 infants that were more than 6 months of age had appropriately been started on complementary feeding from 6 months of age. Overall, most caregivers (88.7% had "fair" to "good" infant feeding practices. The practices were significantly associated with their level of education, and their relationship with the infants. Up to 40.0% and 73.7% of the infants had varying degrees of wasting and stunting respectively. Infant feeding practices and the age of the infants emerged as the only factors significantly associated with stunting, while both the caregivers′ practices and age of the infants emerged as significant predictors of wasting in the infants. Conclusion and Recommendations: Barely 3 years to the 2015 target of the millennium development goals (MDGs, infant feeding and nutritional status still poses a serious threat to the dream of realizing the MDG-4. The Ministry of Health and relevant developing partners in this region should as a matter of urgency, formulate and implement a strong community-based public health intervention program to

  6. Predictors of Vaccination Card Retention in Children 12-59 months old in Karachi, Pakistan

    Directory of Open Access Journals (Sweden)

    Sana Sadiq Sheikh

    2014-05-01

    Full Text Available Objective: To determine the factors associated with retaining the vaccination card among care takers of 12-59 months old children in Karachi, Pakistan. Methods: This was an analytical cross-sectional study in Karachi. Households were randomly selected throughout a multistage cluster sampling technique. Data was collected for 504 children of 12- 59 months of age. Questionnaire was administered to caretakers to gather information regarding the children’s vaccination status, socio-demographic characteristics and reviewing their vaccination cards. Statistical analysis was done by SPSS 19 using logistic regression. Results: Among 462 vaccinated children, caretakers of 33% provided vaccination cards. Odds of card retention decrease if the caretaker has a large household i.e., >5 people sharing one room (AOR 0.277, 95% CI: 0.096, 0.797 and if the child is of four to five years of age (AOR 0.544, 95% CI: 0.305, 0.970. Gender of the child, and the caretaker’s education and access to electronic media were not significant predictors of vaccination card retention in our study. Conclusion: Our study showed that vaccination card retention for children 12-59 months of age was low (33% in Karachi. There is a need to educate caretakers of young children regarding the importance of keeping vaccination card and to disseminate this information through healthcare providers. Improving vaccination card retention is one of the key measures which will help towards accurately estimating coverage and to inform health policy decisions.

  7. Febrile infection-related status epilepticus in a child after a common infection

    DEFF Research Database (Denmark)

    Andersen, Anne Helene; Hansen, Lars Kjærsgaard

    2014-01-01

    A 13-year-old boy developed seizures and intractable status epilepticus a week after having had a sore throat. Ketogenic diet possibly had some effect. Antibodies to calmodulin dependent protein kinase II were found and could possibly suggest an immunologic aetiology.......A 13-year-old boy developed seizures and intractable status epilepticus a week after having had a sore throat. Ketogenic diet possibly had some effect. Antibodies to calmodulin dependent protein kinase II were found and could possibly suggest an immunologic aetiology....

  8. Altered Mental Status in a Child With an Unwitnessed Fall: A Case Report.

    Science.gov (United States)

    Fleurat, Michelle R; Zaia, Brita E

    2016-06-01

    We report a case of altered mental status in a 5-year-old boy who presented to the emergency department after presumed head trauma. A computed tomography head was conducted and its findings were normal, and the boy was discharged home. He returned the next day with persistent altered mental status and was found to have an abnormal MR brain suggestive of embolic strokes. An echocardiogram revealed a large atrial mass that was later confirmed by pathology to be an atrial myxoma. This is a unique and, to our knowledge, unreported presentation of a known but rare disease process in a pediatric patient. PMID:27253357

  9. Longitudinal changes in the time parents spend in activities with their adolescent children as a function of child age, pubertal status, and gender.

    Science.gov (United States)

    Dubas, Judith Semon; Gerris, Jan R M

    2002-12-01

    This study examined the time Dutch mothers (N = 301) and fathers (N = 255) spend per day engaging in 4 activities (going somewhere, doing something, watching TV, and eating together) with their adolescent children both concurrently and 5 years later. Also assessed was whether parent-child shared time was related to parent or child gender and whether age-related differences could be explained by adolescent pubertal status, family conflict, adolescent and parent work or volunteer hours, parental work stress, and adolescent computer use. Finally, the study examined whether family conflict predicted changes in shared time and whether shared time predicted changes in conflict. The findings showed that age changes depended on the activity and that pubertal status mediated age differences in TV viewing among mixed-gender parent-child pairs. Shared time during pre-, early, and mid-adolescence was linked to decreases in family conflict 5 years later.

  10. Analysis on vaccination status of 5 kinds of extra EPI vaccines in Jiangdong District%江东区5种二类疫苗接种情况分析

    Institute of Scientific and Technical Information of China (English)

    方建; 徐林; 刘军涛; 孙灵英; 董斌

    2012-01-01

    OBJECTIVE To analyze the vaccination status of 5 kinds of extra EPI vaccines in Jiangdong district. METHODS 13 133 children between 2 and 5 years old were selected, the immunization coverage rate was analyzed. RESULTS The immunization coverage rate of 5 kinds of extra EPI vaccines were between 7.04% and 88.24%, and the average immunization coverage rate was 36.32%; In addition to pneumococcal vaccines, the vaccine immunization rates of other 4 kinds of types of extra EPI vaccines among the floating children were higher than the local children; the average immunization coverage rate among the floating children and the local children were 38.03% and 34.43%. CONCLUSION The floating children's inoculation rates of extra EPI vaccines are higher than the local children' s; Putting the extra EPI vaccines into management plan is the most useful method to improve the inoculation rates.%目的 分析江东区5种二类疫苗接种情况.方法 选取江东区13 133例2~5周岁的儿童为研究对象,分析其二类疫苗接种情况.结果5种二类疫苗接种率在7.04%~88.24%之间,平均接种率为36.32%;除水痘疫苗外,其余4种疫苗的接种率流动儿童均高于本地儿童;流动儿童5种二类疫苗平均接种率为38.03%,本地儿童平均接种率为34.43%.结论该区流动儿童二类疫苗接种率高于本地儿童;将更多二类疫苗纳入一类疫苗管理是提高二类疫苗接种率的最有效方法.

  11. A comparison of folate status in women of child-bearing age in Korea and in the United States

    Directory of Open Access Journals (Sweden)

    Hyun T

    2012-07-01

    Full Text Available Taisun Hyun,1 Suguna Badiga,2 Han Byul Jang,1 Young-Hee Han,1 Chandrika J Piyathilake21Department of Food and Nutrition, Chungbuk National University, Cheongju, Korea; 2Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USABackground: Even though several studies have demonstrated that periconceptional supplementation with folic acid (FA reduces the occurrence of neural tube defects, FA fortification has been a topic of intense debate due to the possible adverse effects of higher folate status on several health conditions. Several countries, including Korea, have been indecisive as to whether fortification is warranted or not. It is therefore helpful for these countries to compare folate concentrations in their populations with populations exposed to mandatory FA fortification.Purpose: To evaluate the differences in the distribution of circulating concentrations of folate in Korea and the United States (US at different time points.Methods: The Korean study populations consisted of women of child-bearing age recruited in 1999 and in 2009. The US study populations consisted of women of child-bearing age recruited in the post FA fortification era (2005 and 2009. Plasma and red blood cell (RBC folate concentrations were measured using the Lactobacillus casei microbiological assay.Results: The percentage of US women with neural tube defect-protective levels of RBC folate was significantly higher compared to Korean women in 1999 and 2009. However, in 2009, when FA supplements became readily available for Koreans, 50% of Korean women in the study achieved the neural tube defect-protective level of RBC folate; 11% of them demonstrating supraphysiologic concentrations of plasma folate. Even though FA fortification in the US resulted in more than 80of women achieving >400 ng/mL of RBC folate by 2009, nearly 50% also demonstrated having supraphysiologic concentrations of plasma folate, which prompted some researchers to

  12. Does Socioeconomic Status Matter? A Meta-Analysis on Parent Training Effectiveness for Disruptive Child Behavior

    Science.gov (United States)

    Leijten, Patty; Raaijmakers, Maartje A. J.; de Castro, Bram Orobio; Matthys, Walter

    2013-01-01

    Disadvantaged family socioeconomic status (SES) is often assumed to diminish parent training program effectiveness. In examining effects of SES, influences of initial problem severity have been largely ignored. In the present meta-analysis, we examined (a) whether there is a differential influence of SES on parent training effectiveness at…

  13. Parent-child parallel nutritional status assessment using silhouette rating scales

    Directory of Open Access Journals (Sweden)

    Jorga Jagoda B.

    2004-01-01

    Full Text Available Introduction The aim of this study was to determine the validity of silhouettes in assessing genetic factors of obesity in school children aged 12-14. Material and methods 290 primary school students aged 12-14 from Belgrade had undergone body height and weight measurements as well as answering questionnaires. Silhouette rating scales were used to assess the nutritional status of students (6-silhouette scale and their parents (9-silhouette scale. Results Significant differences in body mass index (BMI were found among children whose parents had been rated "normal" and those rated “problematic”. BMI status and gender significantly affected assessment of the nutritional status. An interaction between factors was found (F (1.230 =7.017, p<0.01. The majority of children from the normal BMI category (64.5% selected silhouettes 3 and 4 to describe their current appearance. On the other hand, 70% of children with problematic BMI selected silhouettes 5 and 6. Girls generally selected significantly smaller silhouettes than boys. Girls within the problematic BMI category selected significantly bigger silhouettes for their mother's than the other children. Boys within the normal BMI category, selected significantly bigger silhouettes representing their father’s body size. Discussion According to the results, silhouette rating scales appear to be reliable in parallel assessment of the nutritional status of children and their parents. This subject can be further developed by acquiring data on parents` height and body mass.

  14. Women's work in farming, child feeding practices and nutritional status among under-five children in rural Rukwa, Tanzania.

    Science.gov (United States)

    Nordang, Sunniva; Shoo, Tiransia; Holmboe-Ottesen, Gerd; Kinabo, Joyce; Wandel, Margareta

    2015-11-28

    Some progress has been achieved in reducing the prevalence of undernutrition among children under 5 years of age in Tanzania. In the Rukwa region (2010), the level of stunted and underweight children was 50·4 and 13·5 %, respectively. The aim of this study was to assess the nutritional status of children under 5 years of age, feeding practices and risk factors of undernutrition in a rural village in the Rukwa region, as well as to discuss the results in light of a similar study conducted in 1987/1988. This cross-sectional study was conducted in 152 households with children under 5 years of age. Data were obtained from the child's main caretaker and the household head, using a structured questionnaire and a 24 h dietary recall. Children's length/height and weight were measured. The prevalence of stunting and underweight was found to be 63·8 and 33·6 % (Z-scorechild-feeding practices were not in line with WHO recommendations. Women working in farms, food shortage, dry-season cultivation and diseases partly explain the children's poor nutritional status.

  15. Efficacy of Nursing Safety Management in Child Vaccination%儿童预防接种护理安全管理的实施效果观察

    Institute of Scientific and Technical Information of China (English)

    卢立娜; 朱会群

    2015-01-01

    目的:分析儿童安全预防接种护理的实施效果。方法选取200例接受预防接种儿童,随机分为对照组(100例)与研究组(100例),对照组采取常规免疫接种,研究组采取安全预防接种护理,对比两组护理效果。结果研究组家长满意度、知晓率分别为98.00%(98/100)、92.00%(92/100),对照组分别为89.00%(89/100)、81.00%(81/100),研究组高于对照组(P<0.05)。研究组儿童配合率、疫苗接种率分别为80.00%(80/100)、96.00%(96/100),对照组分别为67.00%(67/100)、88.00%(88/100),研究组高于对照组(P<0.05)。结论采取儿童安全预防接种护理能提高儿童配合度与接种率。%ObjectiveTo analysis effect of safety nursing inoculation against child.Methods Chose 200 patients who underwent vaccination of children,were randomly divided into control group(100)and(100)study group,control group adopted routine immunization and vaccination team take safety nursing,nursing effect compared to two groups.ResultsThe team parents satisfaction and witting rate were 98.00% and 98.00% respectively,the control group were 89.00%,81.00%,the team was higher than the control group(P<0.05). Group children matching rate,vaccination rates were 80.00%,96.00%,the control group were 67.00%,88.00%,the team was higher than the control group(P<0.05).Conclusion Take vaccinating children against safety nursing can improve children's cooperation degree and coverage.

  16. Development Status and Trend Analysis in Aquaculture Vaccines%水产疫苗研究开发现状与趋势分析

    Institute of Scientific and Technical Information of China (English)

    王忠良; 王蓓; 鲁义善; 吴灶和

    2015-01-01

    Aquaculture vaccines not only boost immunity of aquatic animals and prevent aquaculture diseases, but also reduce the use of drugs, lower the cost of aquaculture reproduction and solve problems of food safety and environment pollutions caused by drug residues, and finally lead aquaculture to develop in the green and sustainable direction. As thus, aquaculture vaccines become one of the research hotspots in the diseases control for aquatic animals. In this paper, the history of vaccine development, vaccine types, and vaccine delivery methods are summarized. The status and trend of key technologies in aquaculture vaccines are introduced.%水产疫苗不仅能够增强水产动物的免疫力,预防水产病害发生,还能减少各类药物的使用,降低生殖生产成本,解决各种药物残留带来的食品安全和环境污染等问题,使水产养殖业向绿色、可持续方向发展。因此,水产疫苗已成为水产动物病害防治领域的研究热点。综述了水产疫苗的发展历程、水产疫苗种类与接种方式,并介绍了水产疫苗关键技术发展现状与趋势。

  17. Heavy with child? Pregnancy status and stable isotope ratios as determined from biopsies of humpback whales

    Science.gov (United States)

    Clark, Casey T.; Fleming, Alyson H.; Calambokidis, John; Kellar, Nicholas M.; Allen, Camryn D.; Catelani, Krista N.; Robbins, Michelle; Beaulieu, Nicole E.; Steel, Debbie; Harvey, James T.

    2016-01-01

    Understanding reproductive rates of wild animal populations is crucially important for management and conservation. Assessing pregnancy status of free-ranging cetaceans has historically been difficult; however, recent advances in analytical techniques have allowed the diagnosis of pregnancy from small samples of blubber tissue. The primary objectives of this study were as follows: (i) to test the efficacy of blubber progesterone assays as a tool for diagnosing pregnancy in humpback whales (Megaptera novaeangliae); (ii) to estimate the pregnancy rate of humpback whales in Monterey Bay, California; and (iii) to investigate the relationship between stable isotopes and reproductive status of these whales. Progesterone concentrations of female whales fell into two distinct groups, allowing for diagnostic separation of pregnant and non-pregnant individuals. Pregnancy rate varied between years of the study (48.4%% in 2011 and 18.5% in 2012), but fell within the range of other estimates of reproductive success for this population. Stable carbon and nitrogen isotope ratios were examined to investigate the impacts of pregnancy on these values. Neither δ15N nor δ13C varied in a consistent way among animals of different sex or reproductive status. The relationship between δ15N and δ13C was strongly positive for male and non-pregnant female humpbacks; however, no relationship existed for pregnant whales. This difference may be indicative of the effects of pregnancy on δ15N, resulting from tissue synthesis and reduced excretion of nitrogenous waste, as well as on δ13C through increased mobilization of lipid stores to meet the energetic demands of pregnancy. Ultimately, our results support the use of blubber progesterone assays for diagnosing pregnancy in humpback whales and indicate that, when paired with other approaches (e.g. stable isotope analysis), pregnancy status can be an informative tool for addressing questions about animal physiology, ecology and population

  18. Effect of gender and age on the knowledge, attitude and practice regarding hepatitis B and C and vaccination status of hepatitis B among medical students of Karachi, Pakistan

    International Nuclear Information System (INIS)

    Objectives: To determine the vaccination status for hepatitis B and knowledge, attitude and practice (KAP) regarding hepatitis B and C among medical students of Karachi and to evaluate the effects of gender and age on the responses, regarding vaccination and KAP for Hepatitis B and C. Methods: This cross sectional study was conducted in 7 medical colleges/ universities of Karachi. Convenient sampling was used to collect the information. Questionnaire regarding awareness about prevention, transmission, diagnosis, treatment and vaccination availability for hepatitis B and C was completed from each individual. In addition, vaccination status of hepatitis B and the awareness of students regarding post exposure prophylaxis was also documented. One thousand five hundred and nine students participated in this study. Results: The mean age of medical students (1509) was 20.35 +- 1.72 years. Female participants were 1075 (71.2%) and 937 62.1%) of the respondents were studying in public institutions. Eighty five percent of the respondents indicated that they were aware of availability of a vaccine for hepatitis B. Only 57.1% medical students showed excellent knowledge regarding the route of spread of hepatitis B and C. Students showing good knowledge of treatment procedures for hepatitis B and C were 48.2%. Half of the respondents (49.8%) showed good knowledge regarding spread of hepatitis by dental procedures. Seventy six percent of participating medical students did not have any knowledge about the post exposure prophylaxis for hepatitis B and C. Seventy four percent indicated that the hepatitis patients should not be isolated. Seventy nine percent of the students reported that they were vaccinated for hepatitis B and 70.6% of them were completely vaccinated (3 doses). About half of the respondents (49.4%) indicated that they were screened for hepatitis B and only 27.1% were screened for hepatitis C. Half of the students reported that they have had needle pricks in their

  19. The interplay among socioeconomic status, household chaos, and parenting in the prediction of child conduct problems and callous-unemotional behaviors.

    Science.gov (United States)

    Mills-Koonce, W Roger; Willoughby, Michael T; Garrett-Peters, Patricia; Wagner, Nicholas; Vernon-Feagans, Lynne

    2016-08-01

    Child conduct problems (CP) reflect a heterogeneous collection of oppositional, aggressive, norm-violating, and sometimes violent behaviors, whereas child callous-unemotional (CU) behaviors reflect interpersonal styles of interactions reflecting a lack of guilt and empathy as well as uncaring and shallow emotional responses to others. Taken together, high levels of child CP and CU behaviors are thought to identify a relatively homogenous group of children at elevated risk for persistent and more severe problem behaviors across childhood and into adulthood. Although a large body of research has examined the developmental etiology of CP behaviors, only recently has a developmental psychopathology approach been applied to early CU behaviors. The current study examines multiple levels of contextual influences during the first years of life, including family socioeconomic status, household chaos, and parenting behaviors, on CP and CU behaviors assessed during the first-grade year. Whereas previous studies found associations between parenting behaviors and child problem behaviors moderated by household chaos, the current study found no evidence of moderation. However, path analyses suggest that the associations between child CP and CU behaviors and the contextual variables of socioeconomic status (family income and parental education) and household chaos (disorganization and instability) were mediated by maternal sensitive and harsh-intrusive parenting behavior. Analyses are presented, interpreted, and discussed with respect to both bioecological and family stress models of development. PMID:27427804

  20. Do Maternal Knowledge and Attitudes towards Childhood Immunizations in Rural Uganda Correlate with Complete Childhood Vaccination?

    Science.gov (United States)

    Vonasek, Bryan J; Bajunirwe, Francis; Jacobson, Laura E; Twesigye, Leonidas; Dahm, James; Grant, Monica J; Sethi, Ajay K; Conway, James H

    2016-01-01

    Improving childhood vaccination coverage and timeliness is a key health policy objective in many developing countries such as Uganda. Of the many factors known to influence uptake of childhood immunizations in under resourced settings, parents' understanding and perception of childhood immunizations has largely been overlooked. The aims of this study were to survey mothers' knowledge and attitudes towards childhood immunizations and then determine if these variables correlate with the timely vaccination coverage of their children. From September to December 2013, we conducted a cross-sectional survey of 1,000 parous women in rural Sheema district in southwest Uganda. The survey collected socio-demographic data and knowledge and attitudes towards childhood immunizations. For the women with at least one child between the age of one month and five years who also had a vaccination card available for the child (N = 302), the vaccination status of this child was assessed. 88% of these children received age-appropriate, on-time immunizations. 93.5% of the women were able to state that childhood immunizations protect children from diseases. The women not able to point this out were significantly more likely to have an under-vaccinated child (PR 1.354: 95% CI 1.018-1.802). When asked why vaccination rates may be low in their community, the two most common responses were "fearful of side effects" and "ignorance/disinterest/laziness" (44% each). The factors influencing caregivers' demand for childhood immunizations vary widely between, and also within, developing countries. Research that elucidates local knowledge and attitudes, like this study, allows for decisions and policy pertaining to vaccination programs to be more effective at improving child vaccination rates. PMID:26918890

  1. Do Maternal Knowledge and Attitudes towards Childhood Immunizations in Rural Uganda Correlate with Complete Childhood Vaccination?

    Science.gov (United States)

    Vonasek, Bryan J; Bajunirwe, Francis; Jacobson, Laura E; Twesigye, Leonidas; Dahm, James; Grant, Monica J; Sethi, Ajay K; Conway, James H

    2016-01-01

    Improving childhood vaccination coverage and timeliness is a key health policy objective in many developing countries such as Uganda. Of the many factors known to influence uptake of childhood immunizations in under resourced settings, parents' understanding and perception of childhood immunizations has largely been overlooked. The aims of this study were to survey mothers' knowledge and attitudes towards childhood immunizations and then determine if these variables correlate with the timely vaccination coverage of their children. From September to December 2013, we conducted a cross-sectional survey of 1,000 parous women in rural Sheema district in southwest Uganda. The survey collected socio-demographic data and knowledge and attitudes towards childhood immunizations. For the women with at least one child between the age of one month and five years who also had a vaccination card available for the child (N = 302), the vaccination status of this child was assessed. 88% of these children received age-appropriate, on-time immunizations. 93.5% of the women were able to state that childhood immunizations protect children from diseases. The women not able to point this out were significantly more likely to have an under-vaccinated child (PR 1.354: 95% CI 1.018-1.802). When asked why vaccination rates may be low in their community, the two most common responses were "fearful of side effects" and "ignorance/disinterest/laziness" (44% each). The factors influencing caregivers' demand for childhood immunizations vary widely between, and also within, developing countries. Research that elucidates local knowledge and attitudes, like this study, allows for decisions and policy pertaining to vaccination programs to be more effective at improving child vaccination rates.

  2. Nonconvulsive Status Epilepticus Complicating Epstein-Barr Virus Encephalitis in a Child

    Directory of Open Access Journals (Sweden)

    Filippo Greco

    2014-01-01

    Full Text Available Children with acute encephalopathy show prolonged electrographic seizure activity consistent with nonconvulsive status epilepticus (NCSE. Pediatric NCSE is a heterogeneous clinical entity with poor outcome and different etiologies, including central nervous system infection, stroke, toxic-metabolic syndrome, and epileptic syndrome. We report a 4-year-old girl with seizure and behavioral changes in whom the analysis of cerebrospinal fluid by polymerase chain reaction was positive for Epstein-Barr virus. We emphasize the importance of electroencephalography (EEG, and particularly, of continuous EEG monitoring for early recognition and appropriate treatment of this condition.

  3. Parental perceptions, feeding practices, feeding styles, and level of acculturation of Chinese Americans in relation to their school-age child's weight status.

    Science.gov (United States)

    Pai, Hsiao-Liang; Contento, Isobel

    2014-09-01

    Parents influence their child's eating behavior and attitudes directly as food providers and indirectly through their parental feeding styles and feeding concerns and practices. Chinese American parents' practices are likely influenced by culture. The objective of this study was to explore the relationships between parental perceptions, feeding practices, feeding styles, level of parental acculturation (LPA), and child weight status via a self-administered questionnaire. This survey study involved a convenience sample of 712 individuals who were parents of 5- to 10-year old children attending Chinese language after-school programs. The prevalence of overweight was 11.5% and obesity was 11.1%. LPA was not directly predictive of child overweight in multiple regression but from categorical data, Chinese American parents tended to use indulgent (33.2%) and authoritarian (27.9%) feeding styles, with the former increasing with acculturation and the latter decreasing. Indulgent parents had more than expected overweight and obese children, and authoritarian and authoritative parents, fewer. LPA was negatively predictive of pressure to eat healthy foods (p Parental perceptions and concerns about child weight were predictors of child weight. Consequently, parental concerns and responsiveness to child needs without also encouragement (demandingness) to eat healthy foods (indulgent feeding style) may promote overweight. The authoritative parental feeding style may contribute to children having healthy weights and therefore healthy lives.

  4. Parental perceptions, feeding practices, feeding styles, and level of acculturation of Chinese Americans in relation to their school-age child's weight status.

    Science.gov (United States)

    Pai, Hsiao-Liang; Contento, Isobel

    2014-09-01

    Parents influence their child's eating behavior and attitudes directly as food providers and indirectly through their parental feeding styles and feeding concerns and practices. Chinese American parents' practices are likely influenced by culture. The objective of this study was to explore the relationships between parental perceptions, feeding practices, feeding styles, level of parental acculturation (LPA), and child weight status via a self-administered questionnaire. This survey study involved a convenience sample of 712 individuals who were parents of 5- to 10-year old children attending Chinese language after-school programs. The prevalence of overweight was 11.5% and obesity was 11.1%. LPA was not directly predictive of child overweight in multiple regression but from categorical data, Chinese American parents tended to use indulgent (33.2%) and authoritarian (27.9%) feeding styles, with the former increasing with acculturation and the latter decreasing. Indulgent parents had more than expected overweight and obese children, and authoritarian and authoritative parents, fewer. LPA was negatively predictive of pressure to eat healthy foods (p Parental perceptions and concerns about child weight were predictors of child weight. Consequently, parental concerns and responsiveness to child needs without also encouragement (demandingness) to eat healthy foods (indulgent feeding style) may promote overweight. The authoritative parental feeding style may contribute to children having healthy weights and therefore healthy lives. PMID:24816322

  5. Immunogenicity, protective efficacy, and non-replicative status of the HSV-2 vaccine candidate HSV529 in mice and guinea pigs.

    Directory of Open Access Journals (Sweden)

    Marie-Clotilde Bernard

    Full Text Available HSV-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. A replication-deficient mutant virus (dl5-29 has demonstrated promising efficacy in animal models of genital herpes. However, the immunogenicity, protective efficacy, and non-replicative status of the highly purified clinical vaccine candidate (HSV529 derived from dl5-29 have not been evaluated. Humoral and cellular immune responses were measured in mice and guinea pigs immunized with HSV529. Protection against acute and recurrent genital herpes, mortality, latent infection, and viral shedding after vaginal HSV-2 infection was determined in mice or in naïve and HSV-1 seropositive guinea pigs. HSV529 replication and pathogenicity were investigated in three sensitive models of virus replication: severe combined immunodeficient (SCID/Beige mice inoculated by the intramuscular route, suckling mice inoculated by the intracranial route, and vaginally-inoculated guinea pigs. HSV529 immunization induced HSV-2-neutralizing antibody production in mice and guinea pigs. In mice, it induced production of specific HSV-2 antibodies and splenocytes secreting IFNγ or IL-5. Immunization effectively prevented HSV-2 infection in all three animal models by reducing mortality, acute genital disease severity and frequency, and viral shedding. It also reduced ganglionic viral latency and recurrent disease in naïve and HSV-1 seropositive guinea pigs. HSV529 replication/propagation was not detected in the muscles of SCID/Beige mice, in the brains of suckling mice, or in vaginal secretions of inoculated guinea pigs. These results confirm the non-replicative status, as well as its immunogenicity and efficacy in mice and guinea pigs, including HSV-1 seropositive guinea pigs. In mice, HSV529 produced Th1/Th2 characteristic immune response thought to be necessary for an effective vaccine. These results further support the clinical investigation of HSV529 in human subjects as a

  6. Vaccine Safety

    Science.gov (United States)

    ... the safety of Tdap, Meningococcal, and HPV vaccines Human Papillomavirus (HPV) Vaccine is Very Safe Read about the safety of ... Hepatitis A Vaccine Safety Hepatitis B Vaccine Safety Human Papillomavirus (HPV) Vaccine Safety FAQs about HPV Safety Influenza (Flu) Vaccine ...

  7. Adherence to cervical cancer screening varies by human papillomavirus vaccination status in a high-risk population

    Directory of Open Access Journals (Sweden)

    Christopher A. Paynter

    2015-01-01

    Full Text Available Cervical cancer screening has reduced the incidence of cervical cancer over the past 75 years. The primary aim of this study was to determine if women receiving Gardasil™ (HPV4 vaccine participated in future cervical cancer screening at the same rate as that observed for unvaccinated women matched on birth year and health care campus. This is a retrospective cohort study of subjects selected from 27,786 females born from 1980 to 1992 who received health care in the Truman Medical Center safety net health system in Kansas City Missouri, USA. 1154 women 14–26 years old who received at least one dose of HPV4 vaccine between 2006 and 2009 were chosen at random from the vaccine records. 1154 randomly chosen unvaccinated women were age and health campus matched to the vaccinated women and all were followed until July 1, 2013. Women who were screened after 21 years and received three vaccine doses before 21 years, had the lowest screening rate of 24%. Their only predictive factor for screening, compared to the unvaccinated, was being closer to 21 years than 14 years at vaccination (aOR = 1.71 95% CI: 1.45, 2.00. Women vaccinated with three doses and screened at or after 21 years had the highest screening rate of 84% predicting a six-fold increase in screening participation over no vaccine received (aOR = 5.94 95% CI: 3.77, 9.35. Our results suggest that women who receive HPV4 vaccination closer to 21 years, not 14, are more likely to participate in cervical cancer screening in an underserved US population.

  8. Status of prevention of parent to child transmission services among HIV-positive mothers from rural South India

    Directory of Open Access Journals (Sweden)

    Anbarasi Subramaniyan

    2014-01-01

    Full Text Available Background: Tamil Nadu comes under group I high-prevalence state, with <1% prevalence of HIV infection in ante-natal women but above 5% prevalence in high-risk group. One of the ways to control HIV/AIDS in India is through prevention of parent to child transmission (PPTCT, the success of which lies in the utilization of services. Materials and Methods: A descriptive qualitative study was conducted to explore the status of utilization of PPTCT services by rural HIV-positive mothers, in the Gingee Block of Villupuram district, Tamil Nadu. All the mothers who tested positive between June 2006 and May 2010 were interviewed in-depth using an interview guide. Results: There were 21 HIV-positive mothers during this period, 19 of whom gave consent for the study. Thirteen out of 19 mothers (68% received Nevirapine prophylaxis, while 15 out of 20 infants born to these mothers (75% received Nevirapine syrup. During the study period, it was found that 61% of the mothers were not compliant to antiretroviral therapy (ART. Conclusion: Poor access to the ART centers was reflected in majority of the cases (79%. There is a pressing need to improve access to quality PPTCT services especially during the intranatal period.

  9. Emotional and Sexual Correlates of Child Sexual Abuse as a Function of Self-Definition Status.

    Science.gov (United States)

    Vaillancourt-Morel, Marie-Pier; Godbout, Natacha; Bédard, Maryline Germain; Charest, Émilie; Briere, John; Sabourin, Stéphane

    2016-08-01

    Among individuals defined as having been sexually abused based on legal criteria, some will self-report having been abused and some will not. Yet, the empirical correlates of self-definition status are not well studied. Different definitions of abuse may lead to varying prevalence rates and contradictory findings regarding psychological outcomes. The present study examined whether, among legally defined sexual abuse survivors, identifying oneself as having experienced childhood sexual abuse (CSA) was associated with more severe abuse, negative emotional reactions toward the abuse, and current sexual reactions. A convenience sample of 1,021 French-speaking Canadians completed self-report questionnaires online. The prevalence of legally defined CSA was 21.3% in women and 19.6% in men, as compared to 7.1% in women and 3.8% in men for self-defined CSA. Among legally defined sexual abuse survivors, those who identified themselves as CSA survivors had been abused more frequently, were more likely to report a male aggressor, and more often described abuse by a parental figure than those who did not self-identify as abused. Further, self-defined CSA was associated with more negative postabuse reactions and sexual avoidance, whereas those not identifying as sexually abused were more likely to report sexual compulsion. PMID:27364540

  10. Emotional and Sexual Correlates of Child Sexual Abuse as a Function of Self-Definition Status.

    Science.gov (United States)

    Vaillancourt-Morel, Marie-Pier; Godbout, Natacha; Bédard, Maryline Germain; Charest, Émilie; Briere, John; Sabourin, Stéphane

    2016-08-01

    Among individuals defined as having been sexually abused based on legal criteria, some will self-report having been abused and some will not. Yet, the empirical correlates of self-definition status are not well studied. Different definitions of abuse may lead to varying prevalence rates and contradictory findings regarding psychological outcomes. The present study examined whether, among legally defined sexual abuse survivors, identifying oneself as having experienced childhood sexual abuse (CSA) was associated with more severe abuse, negative emotional reactions toward the abuse, and current sexual reactions. A convenience sample of 1,021 French-speaking Canadians completed self-report questionnaires online. The prevalence of legally defined CSA was 21.3% in women and 19.6% in men, as compared to 7.1% in women and 3.8% in men for self-defined CSA. Among legally defined sexual abuse survivors, those who identified themselves as CSA survivors had been abused more frequently, were more likely to report a male aggressor, and more often described abuse by a parental figure than those who did not self-identify as abused. Further, self-defined CSA was associated with more negative postabuse reactions and sexual avoidance, whereas those not identifying as sexually abused were more likely to report sexual compulsion.

  11. Parental socioeconomic status and child intellectual functioning in a Norwegian sample.

    Science.gov (United States)

    Eilertsen, Thomas; Thorsen, Anders Lillevik; Holm, Silje Elisabeth Hasmo; Bøe, Tormod; Sørensen, Lin; Lundervold, Astri J

    2016-10-01

    Socioeconomic status (SES) in childhood has been linked to cognitive function and future academic and occupational success in studies from several countries. However, previous Nordic studies have shown inconsistent results regarding the strength of this link. We therefore investigated the association between SES and cognitive functioning in a sample of 255 Norwegian children, including 151 typically developing children and 104 children with a psychiatric diagnosis. The third edition of the Wechsler Intelligence Scale for Children (WISC-III) to assess cognitive function was used. SES was defined from maternal and paternal education and family income of typically developing children and of a subsample of children with a psychiatric diagnosis. Multiple adjusted regression analyses were used to investigate the relation between SES and cognitive functioning. The analyses showed that SES explained a significant part of the variance of the full-scale WISC-III score and two WISC-III indices (Verbal Comprehension and Freedom from Distractibility). Overall, the strength of the relations was weaker than expected from reports from other non-Nordic countries. Parental education was the only significant individual predictor, suggesting that income was of minor importance as a predictor of cognitive functioning. Further studies should investigate how diverse political and socioeconomic contexts influence the relation between SES and cognitive functioning. PMID:27589048

  12. Generation status as a determinant of influenza vaccination among Mexican-identified adults in California, 2011–12

    OpenAIRE

    Mendiola, Jennifer; Do-Reynoso, Van; Gonzalez, Mariaelena

    2015-01-01

    First generation Latinos often have better health behaviors and outcomes than second and third generation Latinos. This study examined the correlates of seasonal influenza vaccinations among Mexican-identified (Mexican) adults, who make up the largest Latino subgroup in California. A sample of Mexican adults (N = 7493) from the 2011–12 California Interview Health Survey was used to compare the odds of first, second, and third generation Mexicans receiving influenza vaccinations in the past ye...

  13. Status of a Unique Vaccine against hCG for Contraception and Advanced Stage Cancers expressing ectopically hCG

    Directory of Open Access Journals (Sweden)

    Talwar GP

    2015-01-01

    Full Text Available Dear Egon!br God bless you on your 95th Birthday! May you complete 100 years.br Being submitted in your honor is a brief article on my continuing work to make available a unique vaccine preventing pregnancy in women without blocking ovulation, her normal production of sex steroid hormones and retaining her regular menstrual cycles and bleeding profiles.br The vaccine is directed at the Human chorionic gonadotropin (hCG, which emerges following fertilization of the egg [1]. Healthy, non-pregnant women do not make it, the basis on which its detection in serum or urine serves as a reliable test for diagnosis of pregnancy. It plays a critical role in implantation of the embryo & thereby to the onset of pregnancy. The purpose of the vaccine is to generate bioeffective antibodies neutralizing hCG & thereby prevent the onset of pregnancy.br As you can imagine, the making of a workable vaccine, competent to make antibodies against a tolerant molecule to the woman’s immune system (she literally bathes in hCG during pregnancy was not simple. What was also demanded was high immunogenicity of the vaccine to make fairly high titres of antibodies to counteract the large amount of hCG made in early pregnancy. At each stage, it required testing in humans and before that could be done, appropriate toxicology studies & approval of Regulatory and Ethics Committees was needed each taking its time. Eventually the vaccine has to be amenable to industrial production to reach the public, hence a recombinant vaccine had to be developed. Given below is a brief write-up on the evolution of the vaccine against the human chorionic gonadotropin.br Yours, Pran

  14. 猪带绦虫TSOL18疫苗的研制现状%The status in the research of TSOL18 vaccine for Taenia solium

    Institute of Scientific and Technical Information of China (English)

    李文桂; 陈雅棠

    2012-01-01

    Cysticercosis cellulosae is one type of zoonosis seriously endangering human health.It' s mainly prevalent in central Africa,southern Africa,Latin America,eastern Asia and southern Asia.It recently becomes highlight to control this disease by use of vaccines.The review outlined the status in the research of the encoding gene,DNA vaccine and protein vaccine of TSOL18 of Taenia solium.%猪囊尾蚴病是一种严重危害人类健康的人兽共患寄生虫病,主要流行于中非、南非、拉丁美洲、东亚和南亚等地区.采用疫苗防治该病是当前研究的热点.该文对TSOL18的编码基因、DNA疫苗和蛋白疫苗等方面的研究现状进行了综述.

  15. International child health

    DEFF Research Database (Denmark)

    Kruse, Alexandra Y; Høgh, Birthe

    2007-01-01

    diseases and neonatal complications, over half associated with malnutrition. Conditions we could prevent and treat. One of UN's Millennium Development Goals is to reduce child mortality. However child health is more than mortality and morbidity indicators, it includes growth and development. Udgivelsesdato......International child health has improved. Better healthcare strategies, like IMCI, have contributed implementing basic interventions: vaccinations, nutrition supplement, oral rehydration and antibiotics. But 11 million children still die every year before they turn five, most from infectious...

  16. Evaluating the micronutrient status of women of child-bearing age living in the rural disaster areas one year after Wenchuan Earthquake.

    Science.gov (United States)

    Dong, Caixia; Ge, Pengfei; Ren, Xiaolan; Zhao, Xianfeng; Fan, Haoqiang; Yin, Shi-An; Weiderpass, Elisabete

    2014-01-01

    Populations with special physiological state, such as pregnant, nursing and women of child-bearing age, have been identified as nutritionally vulnerable during natural disaster. The objective of this survey was to evaluate the prevalence of anaemia and micronutrient status of women of reproductive age in April 2009 one year after the Wenchuan Earthquake. The survey recruited 58 pregnant, 66 lactating and 242 women of child-bearing age from 19 to 45 years. The concentrations of haemoglobin in whole blood and ferritin and micronutrients in serum were assayed. Among the three groups (pregnant, nursing and child-bearing women), respectively, the prevalence of anaemia was 29.1%, 25.5% and 28.8%; that of iron deficiency was 45.4%, 49.0% and 52.9%; and that of zinc deficiency was 45.4%, 23.0% and 33.5%. The sum of vitamin D deficiency and insufficiency was more than 90% in each group, and the total vitamin B12 deficiency and marginal deficiency prevalence percentages were 47.3%, 17.7% and 35.7%, respectively. The prevalence of vitamin A deficiency and marginal deficiency was 1.8% and 9.1% in pregnant women, 6.1% and 15.2% in nursing women and 8.6% and 21.3% in women of child-bearing age, respectively. Our findings indicated that the micronutrient status of women of reproductive age was poor in the disaster areas. Therefore, improving the micronutrient status of these women should be an urgent priority in these areas.

  17. Immunobiology of Influenza Vaccines

    OpenAIRE

    Gomez Lorenzo, Margarita M.; Fenton, Matthew J.

    2013-01-01

    Vaccination is the primary strategy for prevention and control of influenza. The surface hemagglutinin (HA) protein of the influenza virus contains two structural elements (head and stalk) that differ in their potential utility as vaccine targets. The head of the HA protein is the primary target of antibodies that confer protective immunity to influenza viruses. The underlying health status, age, and gene polymorphisms of vaccine recipients and, just as importantly, the extent of the antigeni...

  18. Vaccines for Drug Abuse

    Science.gov (United States)

    Shen, Xiaoyun; Orson, Frank M.; Kosten, Thomas R.

    2012-01-01

    Current medications for drug abuse have had only limited success. Anti-addiction vaccines to elicit antibodies that block the pharmacological effects of drugs have great potential for treating drug abuse. We review the status for two vaccines that are undergoing clinical trials (cocaine and nicotine) and two that are still in pre-clinical development (methamphetamine and heroin). We also outline the challenges and ethical concerns for anti-addiction vaccine development and their use as future therapeutics. PMID:22130115

  19. Analysis of vaccination certificate of children at admission to child care setting and school in Hefei City, 2010%合肥市2010年入托入学儿童预防接种证查验情况分析

    Institute of Scientific and Technical Information of China (English)

    刘振武; 王晓萍; 张秀军

    2011-01-01

    目的 了解合肥市入托、入学儿童查验接种证工作开展现况及影响因素,为提高规划疫苗接种率和加强学校传染病预防控制提供科学依据.方法 按照统一方案,对合肥市2010年入托、入学儿童预防接种证进行查验.结果 托幼机构及小学查验率为100%,持证率为97.7%.除6岁A+C流脑苗、百破二联(百白破)疫苗、甲肝苗接种率低于90%外,其他疫苗接种率均超过90%.结论 应采取多种措施,促进入托入学接种证查验和计划免疫工作.%Objective To understand the immunization status of the children at the admission to child care setting and school in Hefei City and provide evidence for further improvement of the vaccination rate and infectious disease control and prevention. Methods Examination was conducted on immunization certificate of children in kindergarten and school according to the unified programme in 2010. Results The inspection rate of kindergartens and primary schools was 100%. The possession rate of vaccination certificate was 97.7% in children. And the vaccination rate of Group A + C, DT(DPT) and Hepatitis was lower than 90%, respectively, others was all high than 90%. Conclusion It is suggested that a variety of messures should be taken to promote the examination certificate of children and Expanded Programme on Immunization.

  20. Predicting Maternal Parenting Stress in Middle Childhood: The Roles of Child Intellectual Status, Behaviour Problems and Social Skills

    Science.gov (United States)

    Neece, C.; Baker, B.

    2008-01-01

    Background: Parents of children with intellectual disabilities (ID) typically report elevated levels of parenting stress, and child behaviour problems are a strong predictor of heightened parenting stress. Interestingly, few studies have examined child characteristics beyond behaviour problems that may also contribute to parenting stress. The…

  1. HIV阳性母亲所娩儿童国家免疫规划5种疫苗接种现状调查%Survey On vaccination status of five vaccines belongs to NIP among the children with HIV positive mother

    Institute of Scientific and Technical Information of China (English)

    黄宝卫

    2011-01-01

    目的 了解HIV阳性母亲所娩儿童国家免疫规划(National Immunization Program,NIP)5种疫苗[卡介苗(Bacillus Calmette Guerin,BCG)、口服脊髓灰质炎减毒活疫苗(Oral Poliomyelitis Attenuated Live Vaccine,OPV)、百日咳-白喉-破伤风联合疫苗(Diphtheria-Pertussis-Tetanus Combined Vaccine,DPT)、麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)、乙型肝炎疫苗(Hepatitis B Vaccine,HepB)]的接种现状,探讨提高预防接种率的方法.方法 随机抽查鹿寨县2005-2008年HIV阳性的部分产妇,对这些产妇所娩的48名儿童的预防接种资料进行分析.结果 HIV阳性母亲所娩儿童的OPV、DPT、MV、HepB接种情况较好.BCG接种率和HepB及时率相对较低;OPV、DPT、MV、HepB的单苗合格接种率95%以上,BCG单苗合格接种率和5苗全程合格率分别为85.42%、83.33%.结论 儿童"五苗"接种较好,接种人员严格掌握接种禁忌及提高受种者监护人的预防接种意识,有利于提高NIP疫苗接种率.%Objective To understand the vaccination status of five vaccines belong to national immunization program among children whose mothers were HIV positive, five vaccines were Calmette Cuerin Vaccine ( BCG) . Oral Poliomyelitis Attenuated Live Vaccine (OPV) . Diphtheria - Pertussis - Tetanus Combined Vaccine ( DPT) , Measles Attenuated Live Vaccine ( MV) . Hepatitis B Vaccine ( HepB) . Study the method for improving the immunization rate. Method Randomly sampled and analyzed the vaccination information of 48 children whose mothers were HIV positive during 2005 to 2008 of Luzhai County. Results The vaccination situation of OPV、 DPT、 MV、 HepB among the children were better, BCG vaccination rate and HepB timeliness rate were relatively low. Single qualified vaccination rate of OPV、 DPT、 MV、 HepB were more than 95% . BCG qualified vaccination rate and whole - course qualified vaccination rate of five vaccines were 85. 42% 、83. 33%. Conclusions Coverage rates

  2. The Current Status of the Disease Caused by Enterovirus 71 Infections: Epidemiology, Pathogenesis, Molecular Epidemiology, and Vaccine Development.

    Science.gov (United States)

    Chang, Ping-Chin; Chen, Shou-Chien; Chen, Kow-Tong

    2016-01-01

    Enterovirus 71 (EV71) infections have a major public health impact in the Asia-Pacific region. We reviewed the epidemiology, pathogenesis, and molecular epidemiology of EV71 infection as well as EV71 vaccine development. Previous studies were found using the search terms "enterovirus 71" and "epidemiology" or "pathogenesis" or "molecular epidemiology" or "vaccine" in Medline and PubMed. Articles that were not published in the English language, manuscripts without an abstract, and opinion articles were excluded from the review. The reported epidemiology of cases caused by EV71 infection varied from country to country; seasonal variations in incidence were observed. Most cases of EV71 infection that resulted in hospitalization for complications occurred in children less than five years old. The brainstem was the most likely major target of EV71 infection. The emergence of the EV71 epidemic in the Asia-Pacific region has been associated with the circulation of different genetic lineages (genotypes B3, B4, C1, C2, and C4) that appear to be undergoing rapid evolutionary changes. The relationship between the gene structure of the EV71 virus and the factors that ensure its survival, circulation, and evasion of immunity is still unknown. EV71 infection has emerged as an important global public health problem. Vaccine development, including the development of inactivated whole-virus live attenuated, subviral particles, and DNA vaccines, has been progressing. PMID:27618078

  3. Whose education affects a child's nutritional status? From parents' to household's education

    Directory of Open Access Journals (Sweden)

    Francesco Burchi

    2012-11-01

    Full Text Available BACKGROUND The paper engages in the ongoing debate regarding the determinants of child nutrition in developing countries and stresses the potential contribution of the education of household members other than the child's parents. OBJECTIVE The aim of the paper is threefold: (1 to verify whether there is evidence of the key role of parents' education for children's nutrition; (2 to explore the possible presence of the externalities generated by the literacy of household members different from the child's parents; (3 to test whether there is difference in the influence of these variables on the two indicators of child nutrition, child height-for-age and weight-for-age. METHODS The determinants of child nutrition were analyzed by estimating a series of econometric models through OLS regressions applied on data from the 2003 DHS survey in Mozambique. By means of seemingly unrelated regression together with formal testing we compared the impact of the covariates on the two outcomes. RESULTS In line with previous studies, we find that one year of mother's education increases their children's height-for-age and weight-for-age z-scores by nearly 0.025 and 0.015. The presence of another literate household member has a significant, though limited, effect on child height while it has no influence on child weight. Lastly, there is no statistically significant difference in the effect of parents' education on the two indicators while our measure of proximate literacy has a significantly larger impact on child height. CONCLUSIONS These findings should orient policy-makers toward income-augmenting and education-enhancing policies: the importance of non-parents' literacy opens a further space for investment in education.

  4. Disparities in child health in the Arab region during the 1990s

    Directory of Open Access Journals (Sweden)

    Meyerson-Knox Sonya

    2008-11-01

    Full Text Available Abstract Background While Arab countries showed an impressive decline in child mortality rates during the past few decades, gaps in mortality by gender and socioeconomic status persisted. However, large socioeconomic disparities in child health were evident in almost every country in the region. Methods Using available tabulations and reliable micro data from national household surveys, data for 18 Arab countries were available for analysis. In addition to infant and child mortality, child health was measured by nutritional status, vaccination, and Acute Respiratory Infection (ARI. Within-country disparities in child health by gender, residence (urban/rural and maternal educational level were described. Child health was also analyzed by macro measures of development, including per capita GDP (PPP, female literacy rates, urban population and doctors per 100,000 people. Results Gender disparities in child health using the above indicators were less evident, with most showing clear female advantage. With the exception of infant and child survival, gender disparities demonstrated a female advantage, as well as a large urban advantage and an overall advantage for mothers with secondary education. Surprisingly, the countries' rankings with respect to disparities were not associated with various macro measures of development. Conclusion The tenacity of pervasive intra-country socioeconomic disparities in child health calls for attention by policy makers and health practitioners.

  5. One health/veterinary links associated with TB vaccines

    Science.gov (United States)

    Objectives: participants will understand the current status of veterinary tuberculosis (TB) vaccine research for cattle and wildlife and their potential applications for development of human TB vaccines. Vaccines are lacking for many chronic intracellular pathogens requiring cell-mediated immunity ...

  6. The Complex Interaction between Home Environment, Socioeconomic Status, Maternal IQ and Early Child Neurocognitive Development: A Multivariate Analysis of Data Collected in a Newborn Cohort Study.

    Directory of Open Access Journals (Sweden)

    Luca Ronfani

    Full Text Available The relative role of socioeconomic status (SES, home environment and maternal intelligence, as factors affecting child cognitive development in early childhood is still unclear. The aim of this study is to analyze the association of SES, home environment and maternal IQ with child neurodevelopment at 18 months.The data were collected prospectively in the PHIME study, a newborn cohort study carried out in Italy between 2007 and 2010. Maternal nonverbal abilities (IQ were evaluated using the Standard Progressive Matrices, a version of the Raven's Progressive Matrices; a direct evaluation of the home environment was carried out with the AIRE instrument, designed using the HOME (Home Observation for Measurement of the Environment model; the socioeconomic characteristics were evaluated using the SES index which takes into account parents occupation, type of employment, educational level, homeownership. The study outcome was child neurodevelopment evaluated at 18 months, with the Bayley Scales of Infant and Toddler Development Third Edition (BSID III. Linear regression analyses and mediation analyses were carried out to evaluate the association between the three exposures, and the scaled scores of the three main scales of BSID III (cognitive, language and motor scale, with adjustment for a wide range of potential explanatory variables.Data from 502 mother-child pairs were analyzed. Mediation analysis showed a relationship between SES and maternal IQ, with a complete mediation effect of home environment in affecting cognitive and language domains. A direct significant effect of maternal IQ on the BSID III motor development scale and the mediation effect of home environment were found.Our results show that home environment was the variable with greater influence on neurodevelopment at 18 months. The observation of how parents and children interact in the home context is crucial to adequately evaluate early child development.

  7. Whose education affects a child's nutritional status? From parents' to household's education

    OpenAIRE

    Francesco Burchi

    2012-01-01

    BACKGROUND The paper engages in the ongoing debate regarding the determinants of child nutrition in developing countries and stresses the potential contribution of the education of household members other than the child's parents. OBJECTIVE The aim of the paper is threefold: (1) to verify whether there is evidence of the key role of parents' education for children's nutrition; (2) to explore the possible presence of the externalities generated by the literacy of household membe...

  8. Effects of Socioeconomic Status on Maternal and Child Positive Behaviors in Daily Life Among Youth With Asthma

    OpenAIRE

    Imami, Ledina; Tobin, Erin T.; Kane, Heidi S.; Saleh, Daniel J.; Lupro, Toni H.; Slatcher, Richard B.

    2014-01-01

    Objective Socioeconomic disadvantage is associated with poorer behavioral and emotional outcomes in children with asthma. This study investigated the associations between maternal income and education and naturalistically observed behaviors and affect during everyday parent–child interactions. Methods 53 predominantly low-income youth with asthma, aged 10–17 years, wore a naturalistic event-sampling device, the Electronically Activated Recorder, for 4 days to assess mother and child positive ...

  9. The Role of Health Behaviors and Socioeconomic Status in Explaining the Relationship Between Child Abuse and Cancer

    OpenAIRE

    Alcala, Hector Ernesto

    2015-01-01

    Recent research has linked experiences of child abuse to cancer later in life. However much of the available research has failed to look at the independent effects of child abuse types (i.e. physical, sexual and emotional abuse) and does not attempt to test potential reasons for this association. To address these shortcomings, the purpose of this study is to investigate the contribution of three health behaviors (i.e. smoking, overweight or obesity and alcohol drinking) and two measures of so...

  10. The Current Status of the Disease Caused by Enterovirus 71 Infections: Epidemiology, Pathogenesis, Molecular Epidemiology, and Vaccine Development

    Directory of Open Access Journals (Sweden)

    Ping-Chin Chang

    2016-09-01

    Full Text Available Enterovirus 71 (EV71 infections have a major public health impact in the Asia-Pacific region. We reviewed the epidemiology, pathogenesis, and molecular epidemiology of EV71 infection as well as EV71 vaccine development. Previous studies were found using the search terms “enterovirus 71” and “epidemiology” or “pathogenesis” or “molecular epidemiology” or “vaccine” in Medline and PubMed. Articles that were not published in the English language, manuscripts without an abstract, and opinion articles were excluded from the review. The reported epidemiology of cases caused by EV71 infection varied from country to country; seasonal variations in incidence were observed. Most cases of EV71 infection that resulted in hospitalization for complications occurred in children less than five years old. The brainstem was the most likely major target of EV71 infection. The emergence of the EV71 epidemic in the Asia-Pacific region has been associated with the circulation of different genetic lineages (genotypes B3, B4, C1, C2, and C4 that appear to be undergoing rapid evolutionary changes. The relationship between the gene structure of the EV71 virus and the factors that ensure its survival, circulation, and evasion of immunity is still unknown. EV71 infection has emerged as an important global public health problem. Vaccine development, including the development of inactivated whole-virus live attenuated, subviral particles, and DNA vaccines, has been progressing.

  11. The Current Status of the Disease Caused by Enterovirus 71 Infections: Epidemiology, Pathogenesis, Molecular Epidemiology, and Vaccine Development

    Science.gov (United States)

    Chang, Ping-Chin; Chen, Shou-Chien; Chen, Kow-Tong

    2016-01-01

    Enterovirus 71 (EV71) infections have a major public health impact in the Asia-Pacific region. We reviewed the epidemiology, pathogenesis, and molecular epidemiology of EV71 infection as well as EV71 vaccine development. Previous studies were found using the search terms “enterovirus 71” and “epidemiology” or “pathogenesis” or “molecular epidemiology” or “vaccine” in Medline and PubMed. Articles that were not published in the English language, manuscripts without an abstract, and opinion articles were excluded from the review. The reported epidemiology of cases caused by EV71 infection varied from country to country; seasonal variations in incidence were observed. Most cases of EV71 infection that resulted in hospitalization for complications occurred in children less than five years old. The brainstem was the most likely major target of EV71 infection. The emergence of the EV71 epidemic in the Asia-Pacific region has been associated with the circulation of different genetic lineages (genotypes B3, B4, C1, C2, and C4) that appear to be undergoing rapid evolutionary changes. The relationship between the gene structure of the EV71 virus and the factors that ensure its survival, circulation, and evasion of immunity is still unknown. EV71 infection has emerged as an important global public health problem. Vaccine development, including the development of inactivated whole-virus live attenuated, subviral particles, and DNA vaccines, has been progressing. PMID:27618078

  12. 猪带绦虫45W蛋白疫苗的研制现状%Status of research on a 45W protein vaccine for Taenia solium

    Institute of Scientific and Technical Information of China (English)

    李文桂; 陈雅棠

    2012-01-01

    猪囊尾蚴病是一种严重危害人类健康的人兽共患寄生虫病,主要流行于中非、南非、拉丁美洲、东亚和南亚等地区.采用疫苗防治该病是当前研究的热点.本文对45W蛋白的起源、编码基因和45W蛋白疫苗等方面的研究现状进行了综述.%Cysticercosis cellulosae is a type of zoonosis that serious endangers human health and that is prevalent mainly in central and southern Africa, Latin America, and East and Southern Asia. Attention has focused on using a vaccine to control this disease. This review outlines the status of research on the origins of the 45W protein of Taenia solium, the gene that codes for it, and 45W protein vaccines.

  13. Factors predicting BCG immunization status in northern Nigeria: a behavioral-ecological perspective.

    Science.gov (United States)

    Babalola, Stella; Lawan, Umar

    2009-03-01

    This study examines the predictors of Bacille Calmette-Guérin (BCG) immunization status among infants in northern Nigeria using a behavioral-ecological model. The findings show only 37.3 percent of the children had received BCG vaccine, and reveal that BCG immunization status in northern Nigeria is influenced by multiple layers of factors, including child's characteristics, parental or household factors, community characteristics, vaccine supply and the policy environment. At the child's level, place of birth and ownership of an immunization card are the two most significant predictors. The parental and household predictors of BCG immunization status include maternal use of antenatal care, maternal knowledge about immunization, maternal exposure to child health information, social influence and paternal approval of immunization. Both the regularity of vaccine supply to the health facility and the state of residence are associated independently with BCG immunization status. These findings stress the need for interventions at multiple levels in order to increase BCG immunization status. PMID:19240190

  14. Evaluation of Haemophilus influenzaetype b carrier status among children 10 years after the introduction of Hib vaccine in Brazil

    Directory of Open Access Journals (Sweden)

    Rosemeire Cobo Zanella

    2015-09-01

    Full Text Available The aim of the present study was to assess the prevalence of Haemophilus influenzaetype b (Hib nasopharyngeal (NP colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%. NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558 and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379 and 53.9% (636/1,179, respectively. Hib was identified in 0.6% (16/2,558 of all children in the study, being 0.8% (11/1,379 and 0.4% (5/1,179 among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099 and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608 compared with that at 12-< 24 m of age (35.6%, n = 491. The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine.

  15. Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil.

    Science.gov (United States)

    Zanella, Rosemeire Cobo; Brandileone, Maria Cristina de Cunto; Andrade, Ana Lúcia; Ogassavara, Cinthya Terumi; Fiório, Cleiton Eduardo; Brandão, Angela Pires; Almeida, Samanta Cristine Grassi; Lemos, Ana Paula Silva; Gorla, Maria Cecília; Carvalhanas, Telma Regina; Sato, Helena; Liphaus, Bernadete; Nerger, Maria Lígia; Conde, Monica; Ribeiro, Ana Freitas

    2015-09-01

    The aim of the present study was to assess the prevalence of Haemophilus influenzae type b (Hib) nasopharyngeal (NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine. PMID:26517654

  16. Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil

    Science.gov (United States)

    Zanella, Rosemeire Cobo; Brandileone, Maria Cristina de Cunto; Andrade, Ana Lúcia; Ogassavara, Cinthya Terumi; Fiório, Cleiton Eduardo; Brandão, Angela Pires; Almeida, Samanta Cristine Grassi; Lemos, Ana Paula Silva; Gorla, Maria Cecília; Carvalhanas, Telma Regina; Sato, Helena; Liphaus, Bernadete; Nerger, Maria Lígia; Conde, Monica; Ribeiro, Ana Freitas

    2015-01-01

    The aim of the present study was to assess the prevalence of Haemophilus influenzae type b (Hib) nasopharyngeal (NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine. PMID:26517654

  17. Aluminium allergy and granulomas induced by vaccinations for children

    DEFF Research Database (Denmark)

    Andersen, Rosa Marie O; Zachariae, Claus; Johansen, Jeanne Duus

    2014-01-01

    Vaccination with aluminium-adsorbed vaccines can induce aluminium allergy with persistent itching subcutaneous nodules at the injection site - vaccination granulomas. In this article we give an overview of childhood aluminium-adsorbed vaccines available in Denmark. Through literature studies we...... examine the incidence, the symptoms and the prognosis for the vaccination granulomas and the allergy. Finally we discuss the status in Denmark....

  18. The Role of Attitudes about Vaccine Safety, Efficacy, and Value in Explaining Parents' Reported Vaccination Behavior

    Science.gov (United States)

    LaVail, Katherine Hart; Kennedy, Allison Michelle

    2013-01-01

    Objectives: To explain vaccine confidence as it related to parents' decisions to vaccinate their children with recommended vaccines, and to develop a confidence measure to efficiently and effectively predict parents' self-reported vaccine behaviors. Method: A sample of parents with at least one child younger than 6 years ("n" =…

  19. An Unusual Case of Vaccine-Associated Paralytic Poliomyelitis

    OpenAIRE

    Desai, S.; Diener, T; BJ-K Tan; NJ Lowry; C Talukdar; WM Chrusch; Wiebe, S

    2014-01-01

    The present article reports a case involving an immunocompetent, previously well child who, despite two previous doses of inactivated poliovirus vaccine, developed severe flaccid paralysis consistent with polio after receiving oral polio vaccine.

  20. An Unusual Case of Vaccine-Associated Paralytic Poliomyelitis

    Directory of Open Access Journals (Sweden)

    S Desai

    2014-01-01

    Full Text Available The present article reports a case involving an immunocompetent, previously well child who, despite two previous doses of inactivated poliovirus vaccine, developed severe flaccid paralysis consistent with polio after receiving oral polio vaccine.

  1. Socioeconomic status, child enrichment factors, and cognitive performance among preschool-age children: results from the Follow-Up of Growth and Development Experiences study.

    Science.gov (United States)

    Christensen, Deborah L; Schieve, Laura A; Devine, Owen; Drews-Botsch, Carolyn

    2014-07-01

    Lower cognitive performance is associated with poorer health and functioning throughout the lifespan and disproportionately affects children from lower socioeconomic status (SES) populations. Previous studies reporting positive associations between child home enrichment and cognitive performance generally had a limited distribution of SES. We evaluated the associations of SES and child enrichment with cognitive performance in a population with a wide range of SES, particularly whether enrichment attenuates associations with SES. Children were sampled from a case-control study of small-for-gestational-age (SGA) conducted in a public hospital serving a low SES population (final n=198) and a private hospital serving a middle-to-high SES population (final n=253). SES (maternal education and income) and perinatal factors (SGA, maternal smoking and drinking) were obtained from maternal birth interview. Five child home enrichment factors (e.g. books in home) and preschool attendance were obtained from follow-up interview at age 4.5 years. Cognitive performance was assessed with the Differential Ability Scales (DAS), a standardized psychometric test administered at follow-up. SES and enrichment scores were created by combining individual factors. Analyses were adjusted for perinatal factors. Children from the public birth hospital had a significantly lower mean DAS general cognitive ability (GCA) score than children born at the private birth hospital (adjusted mean difference -21.4, 95% CI: -24.0, -18.7); this was substantially attenuated by adjustment for individual SES, child enrichment factors, and preschool attendance (adjusted mean difference -5.1, 95% CI: -9.5, -0.7). Individual-level SES score was associated with DAS score, beyond the general SES effect associated with hospital of birth. Adjustment for preschool attendance and home enrichment score attenuated the association between individual SES score and adjusted mean DAS-GCA among children born at both of the

  2. Parental rearing as a function of parent's own, partner's, and child's anxiety status: fathers make the difference

    NARCIS (Netherlands)

    S.M. Bögels; L. Bamelis; C. van der Bruggen

    2008-01-01

    Parents of children with anxiety disorders are found to be over controlling and more rejecting in parent-child interactions than parents of control children. However, most studies included mothers, and the rearing behaviour of fathers of anxious children is largely unknown. Also, it remains unclear

  3. The research status of immunization route of the parasite vaccine%寄生虫疫苗免疫途径的研究现状

    Institute of Scientific and Technical Information of China (English)

    万小波; 周必英

    2014-01-01

    寄生虫病是一种呈世界性分布、种类繁多、危害严重的重要疾病.目前防治寄生虫病的方法主要是健康教育、化疗、环境改造等综合防治措施相结合,其中抗寄生虫药一直是主要的防治手段.然而,随着耐药性和人类健康等问题的出现,寄生虫疫苗的研制已成为控制寄生虫病综合防治措施的重要补充手段.用不同的方法接种寄生虫疫苗,其保护效果不尽相同.该文就几种常见的寄生虫疫苗免疫途径研究现状作一综述.%Parasitosis is a group of important,worldwide,various,and dangerous diseases.Right now,the methods for prevention and control of parasitic diseases are the combining measures mainly including health education,chemotherapy,and environmental reconstruction and so on.Antiparasitic agents are always the main prevention and control methods.However,the development of the parasite vaccines has become effective and economic means of control of parasitic diseases,with the emergence of drug-resistance and human health problems.The protective effects against the parasites is different with different immunization methods.This review reported the research status of immunization route of several common parasite vaccines.

  4. 2008-2011年南通市某医院新生儿乙肝疫苗和卡介苗的接种情况%Neonatal vaccination status of hepatitis b vaccine and BCG in a hospital of Nantong City from2008-2011

    Institute of Scientific and Technical Information of China (English)

    施晓燕

    2012-01-01

    目的 了解南通市第一人民医院新生儿首针乙型肝炎(乙肝)疫苗和卡介苗接种情况和未及时接种原因,探讨提高新生儿乙肝疫苗和卡介苗及时接种率和接种率的对策.方法 调查2008-2011年新生儿接种登记资料,对新生儿预防接种情况及未接种原因进行统计分析.结果 2008-2011年6 402名活产新生儿首针乙肝疫苗及时接种率在94.55% ~95.18%,乙肝疫苗接种率在94.68% ~ 98.91%;卡介苗及时接种率在90.07% ~ 92.06%,卡介苗接种率在91.98% ~ 94.98%.不同年份乙肝疫苗及时接种率、卡介苗及时接种率比较,差异无统计学意义(P>0.05).不同年份乙肝疫苗接种率、卡介苗接种率比较,差异有统计学意义(P<0.01).2008、2009年乙肝疫苗和卡介苗及时接种率和接种率比较,差异无统计学意义(P>0.05).2010、2011年乙肝疫苗和卡介苗及时接种率和接种率比较,差异有统计学意义(P<0.01).乙肝疫苗未及时接种主要原因是:早产儿和患病儿,分别占未及时接种者的82.98%和12.46%.卡介苗未及时接种主要原因是:早产儿和患病儿,分别占未及时接种者的58.00%和42.00%.结论 该院新生儿乙肝疫苗和卡介苗接种工作开展较好,接种率呈逐年上升趋势.由临产室尽早为新生儿接种首针乙肝疫苗,提高外来孕妇产检率,正确把握接种禁忌证,出院前符合接种要求的新生儿由新生儿室补种,是提高新生儿首针乙肝疫苗和卡介苗及时接种率和接种率的有效措施.%[ Objective]To understand the neonatal vaccination status of hepatitis b vaccine at first dose and BCG in Nantong First People' s Hospital as well as the untimely vaccination reason, and discus the measures for improving neonatal vaccination rate and timely vaccination rate. [ Methods]The 2008-201 neonatal vaccination registration data were investigated to analyze the neonatal vaccination status and unvaccinated

  5. Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study.

    Science.gov (United States)

    Lynch, Miranda L; Huang, Li-Shan; Cox, Christopher; Strain, J J; Myers, Gary J; Bonham, Maxine P; Shamlaye, Conrad F; Stokes-Riner, Abbie; Wallace, Julie M W; Duffy, Emeir M; Clarkson, Thomas W; Davidson, Philip W

    2011-01-01

    Maternal consumption of fish during the gestational period exposes the fetus to both nutrients, especially the long-chain polyunsaturated fatty acids (LCPUFAs), believed to be beneficial for fetal brain development, as well as to the neurotoxicant methylmercury (MeHg). We recently reported that nutrients present in fish may modify MeHg neurotoxicity. Understanding the apparent interaction of MeHg exposure and nutrients present in fish is complicated by the limitations of modeling methods. In this study we fit varying coefficient function models to data from the Seychelles Child Development Nutrition Study (SCDNS) cohort to assess the association of dietary nutrients and children's development. This cohort of mother-child pairs in the Republic of Seychelles had fish consumption averaging 9 meals per week. Maternal nutritional status was assessed for five different nutritional components known to be present in fish (n-3 LCPUFA, n-6 LCPUFA, iron status, iodine status, and choline) and associated with children's neurological development. We also included prenatal MeHg exposure (measured in maternal hair). We examined two child neurodevelopmental outcomes (Bayley Scales Infant Development-II (BSID-II) Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI)), each administered at 9 and at 30 months. The varying coefficient models allow the possible interactions between each nutritional component and MeHg to be modeled as a smoothly varying function of MeHg as an effect modifier. Iron, iodine, choline, and n-6 LCPUFA had little or no observable modulation at different MeHg exposures. In contrast the n-3 LCPUFA docosahexaenoic acid (DHA) had beneficial effects on the BSID-II PDI that were reduced or absent at higher MeHg exposures. This study presents a useful modeling method that can be brought to bear on questions involving interactions between covariates, and illustrates the continuing importance of viewing fish consumption during pregnancy as a case

  6. Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study

    Energy Technology Data Exchange (ETDEWEB)

    Lynch, Miranda L., E-mail: Miranda_Lynch@urmc.rochester.edu [University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 (United States); Huang, Li-Shan [University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 (United States); Cox, Christopher [Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (United States); Strain, J.J. [University of Ulster, Coleraine, Northern Ireland (United Kingdom); Myers, Gary J. [University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 (United States); Bonham, Maxine P. [University of Ulster, Coleraine, Northern Ireland (United Kingdom); Shamlaye, Conrad F. [Ministry of Health, Republic of Seychelles (Seychelles); Stokes-Riner, Abbie [University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 (United States); Wallace, Julie M.W.; Duffy, Emeir M. [University of Ulster, Coleraine, Northern Ireland (United Kingdom); Clarkson, Thomas W.; Davidson, Philip W. [University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 (United States)

    2011-01-15

    Maternal consumption of fish during the gestational period exposes the fetus to both nutrients, especially the long-chain polyunsaturated fatty acids (LCPUFAs), believed to be beneficial for fetal brain development, as well as to the neurotoxicant methylmercury (MeHg). We recently reported that nutrients present in fish may modify MeHg neurotoxicity. Understanding the apparent interaction of MeHg exposure and nutrients present in fish is complicated by the limitations of modeling methods. In this study we fit varying coefficient function models to data from the Seychelles Child Development Nutrition Study (SCDNS) cohort to assess the association of dietary nutrients and children's development. This cohort of mother-child pairs in the Republic of Seychelles had fish consumption averaging 9 meals per week. Maternal nutritional status was assessed for five different nutritional components known to be present in fish (n-3 LCPUFA, n-6 LCPUFA, iron status, iodine status, and choline) and associated with children's neurological development. We also included prenatal MeHg exposure (measured in maternal hair). We examined two child neurodevelopmental outcomes (Bayley Scales Infant Development-II (BSID-II) Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI)), each administered at 9 and at 30 months. The varying coefficient models allow the possible interactions between each nutritional component and MeHg to be modeled as a smoothly varying function of MeHg as an effect modifier. Iron, iodine, choline, and n-6 LCPUFA had little or no observable modulation at different MeHg exposures. In contrast the n-3 LCPUFA docosahexaenoic acid (DHA) had beneficial effects on the BSID-II PDI that were reduced or absent at higher MeHg exposures. This study presents a useful modeling method that can be brought to bear on questions involving interactions between covariates, and illustrates the continuing importance of viewing fish consumption during pregnancy

  7. Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study

    International Nuclear Information System (INIS)

    Maternal consumption of fish during the gestational period exposes the fetus to both nutrients, especially the long-chain polyunsaturated fatty acids (LCPUFAs), believed to be beneficial for fetal brain development, as well as to the neurotoxicant methylmercury (MeHg). We recently reported that nutrients present in fish may modify MeHg neurotoxicity. Understanding the apparent interaction of MeHg exposure and nutrients present in fish is complicated by the limitations of modeling methods. In this study we fit varying coefficient function models to data from the Seychelles Child Development Nutrition Study (SCDNS) cohort to assess the association of dietary nutrients and children's development. This cohort of mother-child pairs in the Republic of Seychelles had fish consumption averaging 9 meals per week. Maternal nutritional status was assessed for five different nutritional components known to be present in fish (n-3 LCPUFA, n-6 LCPUFA, iron status, iodine status, and choline) and associated with children's neurological development. We also included prenatal MeHg exposure (measured in maternal hair). We examined two child neurodevelopmental outcomes (Bayley Scales Infant Development-II (BSID-II) Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI)), each administered at 9 and at 30 months. The varying coefficient models allow the possible interactions between each nutritional component and MeHg to be modeled as a smoothly varying function of MeHg as an effect modifier. Iron, iodine, choline, and n-6 LCPUFA had little or no observable modulation at different MeHg exposures. In contrast the n-3 LCPUFA docosahexaenoic acid (DHA) had beneficial effects on the BSID-II PDI that were reduced or absent at higher MeHg exposures. This study presents a useful modeling method that can be brought to bear on questions involving interactions between covariates, and illustrates the continuing importance of viewing fish consumption during pregnancy as a case

  8. Advances in vaccine stability monitoring technology.

    Science.gov (United States)

    Zweig, Stephen E

    2006-08-14

    Electronic time-temperature indicator (eTTI) monitors can be programmed to exactly follow the stability characteristics of vaccines with a high degree of realism. The monitors have a visual output, enabling vaccine status to be assessed at a glance, and can also output more detailed statistical data. When packaged with vaccine vials in groups of about 10 vials per box, the eTTI can remain with a vaccine throughout most of the vaccine's lifetime. The monitors can detect essentially all cold-chain breaks, and can detect issues, such as inadvertent freezing, that are presently not detected by other vaccine stability monitors such as Vaccine Vial Monitors (VVM). PMID:16759766

  9. Under-two child mortality according to maternal HIV status in Rwanda: assessing outcomes within the National PMTCT Program

    OpenAIRE

    Mugwaneza, Placidie; Umutoni, Nadine Wa Shema; Ruton, Hinda; Rukundo, Alphonse; Lyambabaje, Alexandre; Bizimana, Jean de Dieu; Tsague, Landry; Wagner, Claire M.; Nyankesha, Elévanie; Muita, Jane; Mutabazi, Vincent; Nyemazi, Jean Pierre; Nsanzimana, Sabin; Karema, Corine; Binagwaho, Agnes

    2011-01-01

    Introduction We sought to compare risk of death among children aged under-2 years born to HIV positive mother (HIV-exposed) and to HIV negative mother (HIV non-exposed), and identify determinants of under-2 mortality among the two groups in Rwanda. Methods In a stratified, two-stage cluster sampling design, we selected mother-child pairs using national Antenatal Care (ANC) registers. Household interview with each mother was conducted to capture socio-demographic data and information related t...

  10. Evaluation on school and child care setting entrance checking of children's vaccination certificates in Dail prefecture in Yunnan province,2010%2010年云南省大理州儿童入托和入学查验预防接种证的现况调查

    Institute of Scientific and Technical Information of China (English)

    刘宇珠; 林灿松; 张颖兰; 张英; 李庆棠

    2011-01-01

    目的 了解云南省大理州托幼机构、小学新生预防接种证查验补种状况,探讨有效管理方法.方法 收集儿童入托和入学查验预防接种证和补证、补种疫苗的报表资料,并进行分类比较和统计分析.结果 2010年大理州12个县(市)中有11个县(市)开展了儿童入托和入学查验预防接种证工作.共查验小学1071所、托幼机构462所,分别占应查小学、托幼机构的92.9% (1071/1153)和86.7% (462/533).查验儿童 71 677人,占应查验人数的91.3 % (71 677/78 522).需补办儿童预防接种证3755人,占查验儿童的5.24% (3755/71 677),补办儿童预防接种证3684人,占需补证人数的98.1% (3684/3755).脊灰糖丸、百白破、乙肝、甲肝、麻腮风(或麻疹)三联、乙脑、流脑、白破二联疫苗的补种率分别为96.7%、98.8%、98.7%、84.4%、94.2%、64.4%、73.9%和75.0%.结论 大理州2010年儿童入托和入学查验预防接种证工作取得明显成效,但查验工作的质量尚有待提高,教育、卫生部门的协调和配合还需进一步加强.%Objective To understand the performance of school and child care settings entrance checking of children's vaccination certificates and re-vaccination for those who missed the previous immunization opportunities and explore effective management method. Methods The classification and statistical analysis were conducted on the information about vaccination certificate checking, re-issue of vaccination certificates and re-vaccination among children who had entered schools and child care settings in Dali. Results In 2010, the survey of children's vaccination certificates checking at school and child care settings entrance was conducted in 1071 primary schools (92. 9% ) and 462 child care settings (86. 7% ) in 11 of 12 counties in Dali. Totally 71 677 children were involved, accounting for 91. 3% of the total. 3755 children missed vaccination certificates, accounting for 5. 24% and 3684 children got new

  11. Effectiveness of typhoid vaccination in US travelers.

    Science.gov (United States)

    Mahon, Barbara E; Newton, Anna E; Mintz, Eric D

    2014-06-17

    Typhoid vaccination is recommended in the United States before travel to countries where typhoid fever is endemic, though little information is available on its effectiveness in travelers. We estimated typhoid vaccination effectiveness (VE) by comparing vaccination status in cases of typhoid fever and paratyphoid fever (Salmonella Paratyphi A infection, against which typhoid vaccine offers no protection) reported in the United States. We included travelers to Southern Asia and excluded persons vaccination status was not reported. From 2008 through 2011, 744 eligible cases (602 typhoid, 142 paratyphoid A) were reported to CDC. Typhoid vaccination was reported for 5% (29/602) of typhoid patients and for 20% (29/142) of paratyphoid A patients. Estimated VE was 80% (95% confidence interval, 66-89%). Because of missing data, we could not estimate VE for specific vaccines. We demonstrated moderate effectiveness of typhoid vaccination in US travelers, supporting vaccination recommendations.

  12. Factors that affect voluntary vaccination of children in Japan.

    Science.gov (United States)

    Shono, Aiko; Kondo, Masahide

    2015-03-10

    Some important vaccinations are not included in the routine childhood immunization schedule in Japan. Voluntary vaccinations are usually paid as an out-of-pocket expense. Low voluntary vaccination coverage rates and high target disease incidence are assumed to be a consequence of voluntary vaccination. Therefore, this study aimed to explore factors associated with voluntary vaccination patterns in children. We conducted an online survey of 1243 mothers from a registered survey panel who had at least one child 2 months to vaccination mainly correlated positively with annual household income and mothers' positive opinions about voluntary vaccinations, but negatively with number of children. Financial support, especially for low income households and households with more than one child, may motivate parents to vaccinate their children. Communication is also an important issue. More opportunities for education and information about voluntary vaccinations should be provided to mothers without distinguishing between voluntary and routine vaccination.

  13. Combining vitamin A and vaccines: convenience or conflict?

    Science.gov (United States)

    Benn, Christine Stabell

    2012-01-01

    with important consequences for mortality. First, a smaller dose of vitamin A was more beneficial than a larger dose for girls. Second, the effect of vitamin A given with DTP vaccine was significantly different from the effect of vitamin A given with measles vaccine, and children, who received vitamin A with DTP vaccine, had higher mortality than children, who had received vitamin A alone, or who did not receive anything. Third, vitamin A given with BCG at birth interacted negatively with subsequent DTP vaccines in girls. Fourth, the effect of vitamin A to older children in Ghana depended on vaccination status, being beneficial in boys, but harmful in girls who received DTP vaccine during follow-up. The results also show that boys and girls respond differently to vitamin A and vaccines. It is a common assumption within public health in low-income countries that interventions can be combined without producing unexpected consequences. The work presented in this thesis confronts this assumption; the results show that vitamin A and vaccines should be seen not only as specific interventions with specific and independent effects, but as immuno-modulators, which can interact with important consequences for overall mortality. Combining interventions can be convenient and lead to synergistic health benefits, but we documented several examples, where it also leads to unexpectedly increased mortality. Thus, to optimise the child health intervention policy in low-income countries a shift in paradigm is needed. Health interventions should no longer be seen as merely specific and independent, and the policy should probably not be the same for boys and girls. Though more complex, it is necessary to evaluate all health interventions in terms of their effect on overall mortality - and their potential interactions with other health interventions and potential sex-differential effects should always be investigated. Only in this way can we assure that the children in the poorest countries

  14. Alimentação, estado nutricional e condição bucal da criança Food, nutritional status and oral condition of the child

    Directory of Open Access Journals (Sweden)

    Luciana Rodrigues Vieira Batista

    2007-04-01

    Full Text Available A relação entre alimentação, estado nutricional e a condição bucal ainda não está bem esclarecida, apresentando, muitas vezes, versões controversas e conhecimento limitado. Existe certa concordância de que a alimentação e, conseqüentemente, o estado nutricional, possam exercer certa influência sobre a condição bucal imediata e futura da criança. O objetivo desta comunicação é apresentar possíveis relações entre alimentação, estado nutricional e a condição bucal da criança. O estado nutricional pode afetar os dentes durante o seu período de formação e após a erupção na cavidade bucal. Os efeitos sistêmicos provenientes da nutrição podem alterar o desenvolvimento dos dentes, a quantidade e a qualidade da saliva, assim como os efeitos externos também podem determinar uma maior prevalência de cárie dentária, uma vez que tanto a quantidade de sacarose ingerida, quanto a freqüência de ingestão são importantes fatores envolvidos em sua etiologia. As reflexões deste trabalho sugerem a necessidade de ações interdisciplinares para obtenção de resultados na prevenção e no tratamento das doenças bucais.The relationship among food, nutritional status and oral condition is not yet well established, many times presenting controversial versions and limited knowledge. There seems to be an agreement that eating, and consequently, the nutritional status, may have a certain amount of influence over present and future oral conditions of the child. The objective of this communication is to discuss possible relations among food, nutritional status and oral condition in the child. Nutritional status may affect the teeth during their formation period and after eruption in the oral cavity. Systemic effects of nutrition may alter the development of teeth, quantity and quality of saliva, and the external effect may also determine a bigger prevalence of dental cavities, since both the quantity and the frequency of

  15. Splitting hair for cortisol? Associations of socio-economic status, ethnicity, hair color, gender and other child characteristics with hair cortisol and cortisone.

    Science.gov (United States)

    Rippe, Ralph C A; Noppe, Gerard; Windhorst, Dafna A; Tiemeier, Henning; van Rossum, Elisabeth F C; Jaddoe, Vincent W V; Verhulst, Frank C; Bakermans-Kranenburg, Marian J; van IJzendoorn, Marinus H; van den Akker, Erica L T

    2016-04-01

    The aim of this study was to examine associations of SES and ethnicity with hair cortisol and cortisone and to identify potential child and family characteristics that can assist in choosing covariates and potential confounders for analyses involving hair cortisol and cortisone concentrations. Hair samples were collected in 2484 6-year-old children from the Generation R Study, a prospective cohort in Rotterdam, the Netherlands. Measurements for cortisol and cortisone were used as the outcome in regression analyses. Predictors were SES, ethnicity, hair color and child characteristics such as birthweight, gestational age at birth, BMI, disease, allergy, and medication use. Lower family income, more children to be supported by this income, higher BMI and darker hair color were associated with higher hair cortisol and cortisone levels. Boys also showed higher levels. Ethnicity (Dutch and North European descent) was related to lower levels. High amounts of sun in the month of hair collection was related to higher levels of cortisone only. More recent hair washing was related to lower levels of cortisol and cortisone. Gestational age at birth, birth weight, age, medication use, hair washing frequency, educational level of the mother, marital status of the mother, disease and allergy were not associated with cortisol or cortisone levels. Our results serve as a starting point for choosing covariates and confounders in studies of substantive predictors or outcomes. Gender, BMI, income, the number of persons in a household, ethnicity, hair color and recency of hair washing are strongly suggested to take into account.

  16. Growing up together: cohort composition and child investment.

    Science.gov (United States)

    Jones, Kelly M

    2014-02-01

    In sub-Saharan Africa, 60 % of child deaths are preventable by investments in child health as simple as immunizations, bed nets, or water purification. This article investigates how a household's decisions regarding such investments are affected by the size and gender composition of a child's cohort. I focus on a previously overlooked type of investment: nonrival, child-specific goods (club goods). I empirically estimate the response of immunization status to cohort characteristics. I carefully address the problem of endogenous fertility, which is common in cohort studies. Because most rural Senegalese households are composed of multiple nuclear families, a child's cohort is composed of both siblings and nonsibling children. Estimating within households, I instrument cohort characteristics with those of the nonsibling (exogenous) portion. I find that children with larger (or more predominantly male) cohorts of vaccine-eligible age are significantly more likely to receive immunization. These findings suggest that children with larger cohorts may be better off in terms of club investments; this is a significant finding for child health given that many illness prevention methods are of a club good nature. PMID:24072608

  17. 农村儿童保健系统管理和预防接种情况调查%Investigation on child health care system management and vaccination situations in rural area

    Institute of Scientific and Technical Information of China (English)

    胡月; 龚磊; 陈福宽; 孙大勤; 王萱萱; 董昀球; 康琦; 陈家应

    2012-01-01

    目的:了解农村地区儿童保健系统管理和预防接种情况.方法:采取多阶段分层随机抽样方法,通过自行设计的儿童系统管理保健情况和预防接种情况调查表对抽取的样本入户进行定量调查.结果:有45名儿童的母亲在产后有医务人员到家中访视,占91.8%,2人未接受产后访视,还有2人记不清,各占4.1%.平均访视次数为3.2次.产后访视主要由村卫生室医生进行,占88.9%,乡镇卫生院医生访视占8.9%,市县妇幼保健所医生访视占2.2%.97.8%的产后访视在村卫生室和乡镇卫生院进行;受访儿童建卡率100.0%,绝大部分按时接种疫苗.接种中,有97.3%的医务人员告知了孩子家长所接种疫苗的品种、作用原理、禁忌证、不良反应及注意事项,有1.8%的医务人员未告知,还有0.9%的家长不知道医务人员是否告知.结论:调查地区儿童保健管理较系统和全面,预防接种工作开展较好,但仍需要提高乡、村两级医疗机构的应急反应能力与医疗水平.%Objective; To understand child health care system management and vaccination situations in rural area. Methods; Multistage stratified random sampling method and a self - designed questionnaire were used to survey the respondents quantitatively. Results: The mothers of 45 children were visited by medical workers after delivery, accounting for 91. 8% ; two mothers didnt receive postpartum visit, accounting for 4. 1% ; and two mothers couldnt remember the situation, accounting for 4. 1%. The mean times of postpartum visit was 3. 2 times. Postpartum visit was conducted by medical workers from village clinics (88. 9% ) , township hospitals (8. 9% ) , and maternal and child health institutions at city/county level (2. 2% ) . 97. 8% of postpartum visit was carried out in village clinics and township hospitals ; 100. 0% of the children established cards, most of the children vaccinated regularly. In the course of vaccination

  18. 温州市龙湾区流动儿童国家免疫规划疫苗接种状况%Vaccination status for national immunization program among migrant children in Longwan District of Wenzhou City

    Institute of Scientific and Technical Information of China (English)

    朱珠英; 王晓红; 叶芳; 朱培茜

    2013-01-01

    [目的]了解温州市龙湾区流动儿童国家免疫规划( national immunization program ,NIP)疫苗免疫接种状况,探讨影响流动儿童接种率的因素。[方法]采用PPS抽样方法,抽取30个行政村(居委会),对2009-2011年出生的366名流动儿童,入户调查NIP疫苗免疫接种状况。[结果]流动儿童建预防接种卡率为92.90%,建预防接种证率为99.73%,1剂卡介苗( BCG)、3剂口服脊髓灰质炎减毒活疫苗( OPV)、3剂白喉-破伤风-百日咳联合疫苗(DTP)、1剂含麻疹成分疫苗(MCV)、3剂乙型肝炎疫苗(HepB)(以上简称五苗)、1剂流行性乙型脑炎疫苗(JEV)、2剂脑膜炎球菌多糖疫苗(MPV)和甲型肝炎疫苗(HepA)基础免疫(初种)接种率,分别为98.09%、95.08%、92.90%、91.53%、95.36%、65.30%、74.74%和61.34%,HepB首针及时接种率为88.52%,BCG疤痕率为96.58%,五苗全程接种率为81.97%;MCV复种接种率为78.87%,DTP、JEV加强免疫接种率分别为68.04%、57.95%。不合格接种发生率为1.91%~42.05%,HepA最高,BCG最低。[结论] BCG、OPV、DTP、MCV、HepB基础免疫(初种)接种率均>90%,其加强免疫(复种)和JEV、MPV、HepA接种率较低,是目前流动儿童管理的薄弱环节。超期接种、未接种或未全程接种是不合格接种的主要原因。%To investigate the status on vaccination for National Immunization Program ( NIP) among migrant children in Longwan District of Wenzhou City , and to explore the factors that influ-enced the vaccination rate in migrant children . [ Methods] By using PPS sampling method , a series of 366 migrant children who were born from January 1, 2009 to December 31,2011 were investigated for NIP vaccine immunization status by household visit in 30 towns. [ Results] The percentage of migrant chil-dren with vaccination card and

  19. Leptospirosis vaccines

    Directory of Open Access Journals (Sweden)

    Jin Li

    2007-12-01

    Full Text Available Abstract Leptospirosis is a serious infection disease caused by pathogenic strains of the Leptospira spirochetes, which affects not only humans but also animals. It has long been expected to find an effective vaccine to prevent leptospirosis through immunization of high risk humans or animals. Although some leptospirosis vaccines have been obtained, the vaccination is relatively unsuccessful in clinical application despite decades of research and millions of dollars spent. In this review, the recent advancements of recombinant outer membrane protein (OMP vaccines, lipopolysaccharide (LPS vaccines, inactivated vaccines, attenuated vaccines and DNA vaccines against leptospirosis are reviewed. A comparison of these vaccines may lead to development of new potential methods to combat leptospirosis and facilitate the leptospirosis vaccine research. Moreover, a vaccine ontology database was built for the scientists working on the leptospirosis vaccines as a starting tool.

  20. Pneumococcal vaccine.

    OpenAIRE

    1999-01-01

    Streptococcus pneumoniae is a frequent cause of pneumonia and meningitis. This article looks at the pneumococcal vaccine, its uses, efficacy, and adverse effects and how vaccination may be improved. We also look at the role of the new conjugate vaccines.

  1. Smallpox Vaccination

    Science.gov (United States)

    ... Newsletters Events Also Known As Smallpox = Vaccinia Smallpox Vaccination Recommend on Facebook Tweet Share Compartir The smallpox ... like many other vaccines. For that reason, the vaccination site must be cared for carefully to prevent ...

  2. Dismantling the Taboo against Vaccines in Pregnancy.

    Science.gov (United States)

    de Martino, Maurizio

    2016-01-01

    Vaccinating pregnant women in order to protect them, the fetus, and the child has become universal in no way at all. Prejudice in health professionals add to fears of women and their families. Both these feelings are not supported by even the smallest scientific data. Harmlessness for the mother and the child has been observed for seasonal, pandemic, or quadrivalent influenza, mono, combined polysaccharide or conjugated meningococcal or pneumococcal, tetanus toxoid, acellular pertussis, human papillomavirus, cholera, hepatitis A, Japanese encephalitis, rabies, anthrax, smallpox, yellow fever, mumps, measles and rubella combined, typhoid fever, inactivated or attenuated polio vaccines, and Bacillus Calmétte Guerin vaccines. Instead, the beneficial effects of influenza vaccine for the mother and the child as well as of pertussis vaccine for the child have been demonstrated. Obstetrician-gynecologists, general practitioners, and midwives must incorporate vaccination into their standard clinical care. Strong communication strategies effective at reducing parental vaccine hesitancy and approval of regulatory agencies for use of vaccines during pregnancy are needed. It must be clear that the lack of pre-licensure studies in pregnant women and, consequently, the lack of a statement about the use of the vaccine in pregnant women does not preclude its use in pregnancy. PMID:27338346

  3. Dismantling the Taboo against Vaccines in Pregnancy

    Directory of Open Access Journals (Sweden)

    Maurizio de Martino

    2016-06-01

    Full Text Available Vaccinating pregnant women in order to protect them, the fetus, and the child has become universal in no way at all. Prejudice in health professionals add to fears of women and their families. Both these feelings are not supported by even the smallest scientific data. Harmlessness for the mother and the child has been observed for seasonal, pandemic, or quadrivalent influenza, mono, combined polysaccharide or conjugated meningococcal or pneumococcal, tetanus toxoid, acellular pertussis, human papillomavirus, cholera, hepatitis A, Japanese encephalitis, rabies, anthrax, smallpox, yellow fever, mumps, measles and rubella combined, typhoid fever, inactivated or attenuated polio vaccines, and Bacillus Calmétte Guerin vaccines. Instead, the beneficial effects of influenza vaccine for the mother and the child as well as of pertussis vaccine for the child have been demonstrated. Obstetrician-gynecologists, general practitioners, and midwives must incorporate vaccination into their standard clinical care. Strong communication strategies effective at reducing parental vaccine hesitancy and approval of regulatory agencies for use of vaccines during pregnancy are needed. It must be clear that the lack of pre-licensure studies in pregnant women and, consequently, the lack of a statement about the use of the vaccine in pregnant women does not preclude its use in pregnancy.

  4. Dismantling the Taboo against Vaccines in Pregnancy

    Science.gov (United States)

    de Martino, Maurizio

    2016-01-01

    Vaccinating pregnant women in order to protect them, the fetus, and the child has become universal in no way at all. Prejudice in health professionals add to fears of women and their families. Both these feelings are not supported by even the smallest scientific data. Harmlessness for the mother and the child has been observed for seasonal, pandemic, or quadrivalent influenza, mono, combined polysaccharide or conjugated meningococcal or pneumococcal, tetanus toxoid, acellular pertussis, human papillomavirus, cholera, hepatitis A, Japanese encephalitis, rabies, anthrax, smallpox, yellow fever, mumps, measles and rubella combined, typhoid fever, inactivated or attenuated polio vaccines, and Bacillus Calmétte Guerin vaccines. Instead, the beneficial effects of influenza vaccine for the mother and the child as well as of pertussis vaccine for the child have been demonstrated. Obstetrician-gynecologists, general practitioners, and midwives must incorporate vaccination into their standard clinical care. Strong communication strategies effective at reducing parental vaccine hesitancy and approval of regulatory agencies for use of vaccines during pregnancy are needed. It must be clear that the lack of pre-licensure studies in pregnant women and, consequently, the lack of a statement about the use of the vaccine in pregnant women does not preclude its use in pregnancy. PMID:27338346

  5. Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children.

    Directory of Open Access Journals (Sweden)

    Carolina Bonilla

    Full Text Available Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC. We then examined the association of SNPs in maternal genes FUT2 (rs492602 and TCN2 (rs1801198, rs9606756 that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child's IQ that was markedly attenuated after adjustment for potential confounders (mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 (95% CI 1.3, 2.8; after adjustment: 0.7 (95% CI -0.04, 1.4. Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 (95% CI 0.1, 1.6. The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted.

  6. The Child Welfare Cartel

    Science.gov (United States)

    Stoesz, David

    2016-01-01

    The probity of the Children's Bureau's National Child Welfare Workforce Institute (NCWWI) is examined with respect to the status of child welfare as well as the performance of social work education. By requiring that funding go only to accredited schools of social work, which is not authorized by relevant provisions of the Social Security Act,…

  7. Vaccine Hesitancy.

    Science.gov (United States)

    Jacobson, Robert M; St Sauver, Jennifer L; Finney Rutten, Lila J

    2015-11-01

    Vaccine refusal received a lot of press with the 2015 Disneyland measles outbreak, but vaccine refusal is only a fraction of a much larger problem of vaccine delay and hesitancy. Opposition to vaccination dates back to the 1800 s, Edward Jenner, and the first vaccine ever. It has never gone away despite the public's growing scientific sophistication. A variety of factors contribute to modern vaccine hesitancy, including the layperson's heuristic thinking when it comes to balancing risks and benefits as well as a number of other features of vaccination, including falling victim to its own success. Vaccine hesitancy is pervasive, affecting a quarter to a third of US parents. Clinicians report that they routinely receive requests to delay vaccines and that they routinely acquiesce. Vaccine rates vary by state and locale and by specific vaccine, and vaccine hesitancy results in personal risk and in the failure to achieve or sustain herd immunity to protect others who have contraindications to the vaccine or fail to generate immunity to the vaccine. Clinicians should adopt a variety of practices to combat vaccine hesitancy, including a variety of population health management approaches that go beyond the usual call to educate patients, clinicians, and the public. Strategies include using every visit to vaccinate, the creation of standing orders or nursing protocols to provide vaccination without clinical encounters, and adopting the practice of stating clear recommendations. Up-to-date, trusted resources exist to support clinicians' efforts in adopting these approaches to reduce vaccine hesitancy and its impact.

  8. Vaccine Hesitancy.

    Science.gov (United States)

    Jacobson, Robert M; St Sauver, Jennifer L; Finney Rutten, Lila J

    2015-11-01

    Vaccine refusal received a lot of press with the 2015 Disneyland measles outbreak, but vaccine refusal is only a fraction of a much larger problem of vaccine delay and hesitancy. Opposition to vaccination dates back to the 1800 s, Edward Jenner, and the first vaccine ever. It has never gone away despite the public's growing scientific sophistication. A variety of factors contribute to modern vaccine hesitancy, including the layperson's heuristic thinking when it comes to balancing risks and benefits as well as a number of other features of vaccination, including falling victim to its own success. Vaccine hesitancy is pervasive, affecting a quarter to a third of US parents. Clinicians report that they routinely receive requests to delay vaccines and that they routinely acquiesce. Vaccine rates vary by state and locale and by specific vaccine, and vaccine hesitancy results in personal risk and in the failure to achieve or sustain herd immunity to protect others who have contraindications to the vaccine or fail to generate immunity to the vaccine. Clinicians should adopt a variety of practices to combat vaccine hesitancy, including a variety of population health management approaches that go beyond the usual call to educate patients, clinicians, and the public. Strategies include using every visit to vaccinate, the creation of standing orders or nursing protocols to provide vaccination without clinical encounters, and adopting the practice of stating clear recommendations. Up-to-date, trusted resources exist to support clinicians' efforts in adopting these approaches to reduce vaccine hesitancy and its impact. PMID:26541249

  9. First Pregnancy, Somatic and Psychological Status of a 4-Year-Old Child Born following Annexin V TESA Sperm Separation

    Directory of Open Access Journals (Sweden)

    Krzysztof Lukaszuk

    2015-10-01

    Full Text Available Introduction - Sperm DNA integrity is a crucial paternal factor affecting fertilization and pregnancy rates, as well as embryo development. Case - The present case report describes the successful pregnancy after testicular sperm aspiration (TESA combined with intracytoplasmic sperm injection (ICSI (TESA-ICSI in a couple where the male presented high sperm DNA fragmentation. In order to sort damaged sperm presenting DNA fragmentation, magnetic activated cell sorting (MACS with annexin V microbeads (MACS Miltenyi Biotec, Teterow, Germany was used. Conclusion - The authors present the first description of a successful medical case using TESA-ICSI annexin V sperm sorting. Additionally, a follow-up of the child at the age of 4 years old was done.

  10. Public awareness regarding children vaccination in Jordan.

    Science.gov (United States)

    Masadeh, Majed M; Alzoubi, Karem H; Al-Azzam, Sayer I; Al-Agedi, Hassan S; Abu Rashid, Baraa E; Mukattash, Tariq L

    2014-01-01

    Immunization can contribute to a dramatic reduction in number of vaccine-preventable diseases among children. The aim of this study is to investigate mothers' awareness about child vaccines and vaccination in Jordan. This study was a community-based, cross-sectional study that was performed at public places in Irbid City. Data was collected from 506 mothers. After verbal approval, mothers were interviewed to assess their knowledge, attitudes, and practice toward vaccination. Results show that majority of mothers had acceptable knowledge and positive attitude toward vaccination. Most of mothers (94.7-86.8%) were able to identify vaccines that are mandatory as per the national vaccination program. Lower knowledge was observed among mothers (71.6%) for HIB vaccination being mandatory. Most mothers (97.2%) had vaccination card for their baby form the national vaccination programs. Vaccination delay was reported by about 36.6% of mothers and was shown to be associated with significantly (P = 0.001) lower vaccination knowledge/attitude score. Additionally, mothers who reported to be regularly offered information about vaccination during visits and those who identified medical staff members as their major information source had significantly higher vaccination knowledge/attitude score (P = 0.002). In conclusion, vaccination coverage rate is high; however, some aspects of knowledge, attitudes, and practice of vaccination need to be improved. Knowledge and attitudes of mothers were directly associated with their practice of vaccination. Medical staff education about vaccination during each visit seems to be the most effective tool that directly reflects on better practice of vaccination such as reducing the possibility for vaccination delay. PMID:24732060

  11. Oral health status and parental perception of child oral health related quality-of-life of children with autism in Bangalore, India

    Directory of Open Access Journals (Sweden)

    Richa

    2014-01-01

    Full Text Available Background: Children with autism present with the physical-mental impairments and oral problems, which may have an impact on their quality-of-life (QoL. The aim of the following study was to assess oral health status and parental perception of child oral health related quality of life (OHRQoL among children with autism. Materials and Methods: A cross-sectional study was conducted in 4-15-year-old children with autism (n = 135 and children without autism (n = 135. Oral health status was evaluated using Oral Hygiene Index-Simplified (OHI-S, its Miglani′s modification for deciduous teeth, Decayed, missing and filled teeth (DMFT/dmft and Decayed, missing and filled surface (DMFS/dmfs indices. Parents answered the Parental-Caregivers Perception Questionnaire for assessing children′s OHRQoL. Mann-Whitney U, Chi-square test and Pearson′s correlation analysis were performed. Results: Mean OHI-S, DMFT, dmft scores were significantly high among children with autism (2.07 ± 0.83; 0.86 ± 1.22, 1.40 ± 2.48 when compared to children without autism (0.46 ± 0.58; 0.46 ± 1.06, 0.59 ± 1.28 respectively. Out of all domains of OHRQoL, mean score of functional limitations related to teeth problem was significantly higher among children with autism (8.87 ± 5.65 as compared to non-autism group (6.66 ± 4.97. Conclusion: Functional limitations may have a negative impact on oral health status that might influence OHRQoL.

  12. Safety and immunogenicity of influenza vaccine among HIV-infected adults: Conventional vaccine vs. intradermal vaccine

    Science.gov (United States)

    Seo, Yu Bin; Lee, Jacob; Song, Joon Young; Choi, Hee Jung; Cheong, Hee Jin; Kim, Woo Joo

    2016-01-01

    Several studies have reported poor immune responses to conventional influenza vaccines in HIV-infected individuals. This study sought to elicit more potent immunogenicity in HIV-infected adults using an intradermal vaccine compared with a conventional intramuscular vaccine. This multicenter, randomized, controlled, open-label study was conducted at 3 university hospitals during the 2011/2012 pre-influenza season. Three vaccines were used in HIV-infected adults aged 18 – 60 years: an inactivated intramuscular vaccine (Agrippal), a reduced-content intradermal vaccine (IDflu9μg) and a standard-content intradermal vaccine (IDflu15μg). Serum hemagglutination-inhibiting (HI) antibodies and INF-γ ELISpot assay were measured at the time of vaccination and 1 month after vaccination. Adverse events were recorded for 7 d. A total of 28 Agrippal, 30 IDflu9μg, and 28 IDflu15μg volunteers were included in this analysis. One month after vaccination, the GMTs and differences in INF-γ ELISpot assay results were similar among the 3 groups. Seroprotection rates, seroconversion rates and mean fold increases (MFI) among the 3 groups were also similar, at approximately 80%, 50–60% and 2.5 – 10.0, respectively. All three vaccines satisfied the CHMP criteria for the A/H1N1 and A/H3N2 strains, but not those for the B strain. In univariate analysis, no demographic or clinical factors, including age, CD4+ T-cell counts, HIV viral load, ART status and vaccine type, were related to failure to achieve seroprotection. The three vaccines were all well-tolerated and all reported reactions were mild to moderate. However, there was a tendency toward a higher incidence of local and systemic reactions in the intradermal vaccine groups. The intradermal vaccine did not result in higher immunogenicity compared to the conventional intramuscular vaccine, even with increased antigen dose. PMID:26431466

  13. The effect of adding ready-to-use supplementary food to a general food distribution on child nutritional status and morbidity: a cluster-randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Lieven Huybregts

    Full Text Available BACKGROUND: Recently, operational organizations active in child nutrition in developing countries have suggested that blanket feeding strategies be adopted to enable the prevention of child wasting. A new range of nutritional supplements is now available, with claims that they can prevent wasting in populations at risk of periodic food shortages. Evidence is lacking as to the effectiveness of such preventive interventions. This study examined the effect of a ready-to-use supplementary food (RUSF on the prevention of wasting in 6- to 36-mo-old children within the framework of a general food distribution program. METHODS AND FINDINGS: We conducted a two-arm cluster-randomized controlled pragmatic intervention study in a sample of 1,038 children aged 6 to 36 mo in the city of Abeche, Chad. Both arms were included in a general food distribution program providing staple foods. The intervention group was given a daily 46 g of RUSF for 4 mo. Anthropometric measurements and morbidity were recorded monthly. Adding RUSF to a package of monthly household food rations for households containing a child assigned to the intervention group did not result in a reduction in cumulative incidence of wasting (incidence risk ratio: 0.86; 95% CI: 0.67, 1.11; p = 0.25. However, the intervention group had a modestly higher gain in height-for-age (+0.03 Z-score/mo; 95% CI: 0.01, 0.04; p<0.001. In addition, children in the intervention group had a significantly higher hemoglobin concentration at the end of the study than children in the control group (+3.8 g/l; 95% CI: 0.6, 7.0; p = 0.02, thereby reducing the odds of anemia (odds ratio: 0.52; 95% CI: 0.34, 0.82; p = 0.004. Adding RUSF also resulted in a significantly lower risk of self-reported diarrhea (-29.3%; 95% CI: 20.5, 37.2; p<0.001 and fever episodes (-22.5%; 95% CI: 14.0, 30.2; p<0.001. Limitations of this study include that the projected sample size was not fully attained and that significantly fewer

  14. Recording actions to prevent child morbidity in children's health cards.

    Science.gov (United States)

    Vieira, Daniele de Souza; Santos, Nathanielly Cristina Carvalho de Brito; Costa, Dayse Kalyne Gomes da; Pereira, Mayara de Melo; Vaz, Elenice Maria Cecchetti; Reichert, Altamira Pereira da Silva

    2016-06-01

    The aim of this study was to analyze the registering of preventative actions in relation to child morbidity using information regarding vaccinations, as well as iron and vitamin A supplements, which are recorded in children's health cards. This transversal study used a quantitative approach and was performed in Family Health Units in the city of João Pessoa, Paraíba; the sampling was by convenience and totaled 116 children's health cards. The data was collected by observing the cards and the analysis was simple, statistical. The highest percentage of children had their vaccination cards up to date (92.2%) and those that did not were aged between 6 and 12 months: 78.9% of the cards did not have records relating to iron and vitamin A supplements and others only had records of one of the supplements being administered. The vaccination status of children in the first year of life was found to be satisfactory; however, discrepancies were observed in the recordings of the administration of iron and vitamin A supplements, which complicates monitoring performed by child health care professionals. It is hoped that this study will contribute to discussions and strategies aimed at improving the monitoring and recording of micronutrients in children's health cards. PMID:27383363

  15. Hepatitis Vaccines

    OpenAIRE

    Ogholikhan, Sina; Schwarz, Kathleen B

    2016-01-01

    Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B ...

  16. The Only Child Factor in Homosexual Development.

    Science.gov (United States)

    Hogan, Robert A.; And Others

    1980-01-01

    An investigation of the life experiences and attitudes of homosexual women with only-child status reveals that their emotional and social development is less favorable than that of homosexual women who had siblings. Only-child status is an important variable in understanding child development. (Author/CS)

  17. Catching-up with pentavalent vaccine: Exploring reasons behind lower rotavirus vaccine coverage in El Salvador.

    Science.gov (United States)

    Suarez-Castaneda, Eduardo; Burnett, Eleanor; Elas, Miguel; Baltrons, Rafael; Pezzoli, Lorenzo; Flannery, Brendan; Kleinbaum, David; de Oliveira, Lucia Helena; Danovaro-Holliday, M Carolina

    2015-11-27

    Rotavirus vaccine was introduced in El Salvador in 2006 and is recommended to be given concomitantly with DTP-HepB-Haemophilus influenzae type b (pentavalent) vaccine at ages 2 months (upper age limit 15 weeks) and 4 months (upper age limit 8 months) of age. However, rotavirus vaccination coverage continues to lag behind that of pentavalent vaccine, even in years when national rotavirus vaccine stock-outs have not occurred. We analyzed factors associated with receipt of oral rotavirus vaccine among children who received at least 2 doses of pentavalent vaccine in a stratified cluster survey of children aged 24-59 months conducted in El Salvador in 2011. Vaccine doses included were documented on vaccination cards (94.4%) or in health facility records (5.6%). Logistic regression and survival analysis were used to assess factors associated with vaccination status and age at vaccination. Receipt of pentavalent vaccine by age 15 weeks was associated with rotavirus vaccination (OR: 5.1; 95% CI 2.7, 9.4), and receipt of the second pentavalent dose by age 32 weeks was associated with receipt of two rotavirus vaccine doses (OR: 5.0; 95% CI 2.1-12.3). Timely coverage with the first pentavalent vaccine dose was 88.2% in the 2007 cohort and 91.1% in the 2008 cohort (p=0.04). Children born in 2009, when a four-month national rotavirus vaccine stock-out occurred, had an older median age of receipt of rotavirus vaccine and were less likely to receive rotavirus on the same date as the same dose of pentavalent vaccine than children born in 2007 and 2008. Upper age limit recommendations for rotavirus vaccine administration contributed to suboptimal vaccination coverage. Survey data suggest that late rotavirus vaccination and co-administration with later doses of pentavalent vaccine among children born in 2009 helped increase rotavirus vaccine coverage following shortages. PMID:26263200

  18. Catching-up with pentavalent vaccine: Exploring reasons behind lower rotavirus vaccine coverage in El Salvador.

    Science.gov (United States)

    Suarez-Castaneda, Eduardo; Burnett, Eleanor; Elas, Miguel; Baltrons, Rafael; Pezzoli, Lorenzo; Flannery, Brendan; Kleinbaum, David; de Oliveira, Lucia Helena; Danovaro-Holliday, M Carolina

    2015-11-27

    Rotavirus vaccine was introduced in El Salvador in 2006 and is recommended to be given concomitantly with DTP-HepB-Haemophilus influenzae type b (pentavalent) vaccine at ages 2 months (upper age limit 15 weeks) and 4 months (upper age limit 8 months) of age. However, rotavirus vaccination coverage continues to lag behind that of pentavalent vaccine, even in years when national rotavirus vaccine stock-outs have not occurred. We analyzed factors associated with receipt of oral rotavirus vaccine among children who received at least 2 doses of pentavalent vaccine in a stratified cluster survey of children aged 24-59 months conducted in El Salvador in 2011. Vaccine doses included were documented on vaccination cards (94.4%) or in health facility records (5.6%). Logistic regression and survival analysis were used to assess factors associated with vaccination status and age at vaccination. Receipt of pentavalent vaccine by age 15 weeks was associated with rotavirus vaccination (OR: 5.1; 95% CI 2.7, 9.4), and receipt of the second pentavalent dose by age 32 weeks was associated with receipt of two rotavirus vaccine doses (OR: 5.0; 95% CI 2.1-12.3). Timely coverage with the first pentavalent vaccine dose was 88.2% in the 2007 cohort and 91.1% in the 2008 cohort (p=0.04). Children born in 2009, when a four-month national rotavirus vaccine stock-out occurred, had an older median age of receipt of rotavirus vaccine and were less likely to receive rotavirus on the same date as the same dose of pentavalent vaccine than children born in 2007 and 2008. Upper age limit recommendations for rotavirus vaccine administration contributed to suboptimal vaccination coverage. Survey data suggest that late rotavirus vaccination and co-administration with later doses of pentavalent vaccine among children born in 2009 helped increase rotavirus vaccine coverage following shortages.

  19. Parent HPV vaccine perspectives and the likelihood of HPV vaccination of adolescent males.

    Science.gov (United States)

    Clark, Sarah J; Cowan, Anne E; Filipp, Stephanie L; Fisher, Allison M; Stokley, Shannon

    2016-01-01

    In 2013, approximately one-third of US adolescent males age 13-17 y had received ≥1 doses of HPV vaccines and only 14% had received ≥3 doses. This study used a nationally representative, online survey to explore experiences and attitudes related to HPV vaccination among parents with adolescent sons. Analyses compared the perspective of parents who do not intend to initiate HPV vaccine for ≥1 adolescent son to that of parents who are likely to initiate or continue HPV vaccination. Of 809 parents of sons age 11-17 years, half were classified as Unlikely to Initiate HPV vaccination and 39% as Likely to Vaccinate. A higher proportion of the Likely to Vaccinate group felt their son's doctor was knowledgeable about HPV vaccine, did a good job explaining its purpose, and spent more time discussing HPV vaccine; in contrast, over half of the Unlikely to Initiate group had never discussed HPV vaccine with their child's doctor. The majority of parents in both groups showed favorable attitudes to adolescent vaccination in general, with lower levels of support for HPV vaccine-specific statements. Physician-parent communication around HPV vaccine for adolescent males should build on positive attitude toward vaccines in general, while addressing parents' HPV vaccine-specific concerns.

  20. Health Status of Immigrant Children and Environmental Survey of Child Daycare Centers in Samut Sakhon Province, Thailand.

    Science.gov (United States)

    Sagnuankiat, Surapol; Wanichsuwan, Molee; Bhunnachet, Ekaporn; Jungarat, Nahathai; Panraksa, Kanitha; Komalamisra, Chalit; Maipanich, Wanna; Yoonuan, Tippayarat; Pubampen, Somchit; Adisakwattana, Poom; Watthanakulpanich, Dorn

    2016-02-01

    Samut Sakhon is a Thai province popular among immigrants attracted to work in factories and the Thai food industry, especially people from Myanmar. Poor personal-hygiene behaviors, crowded accommodation and limited sanitation, result in health problems among immigrant workers. Various infectious diseases among this group are seen and managed by Samut Sakhon General Hospital. The impact of intestinal parasitic infections on public health is well known; they can spread from infected immigrant areas to uninfected areas via close contact and fecal-oral transmission from contaminated food and water. This study aimed to determine the prevalence of intestinal parasitic infections among 372 immigrant children at 8 child-daycare centers during their parents' work time, by physical examination, fecal examination, and examination of the environment around the centers. Physical examinations were generally unremarkable, except that head-lice and fingernail examinations were positive in two cases (0.8 %). The results showed intestinal parasitic infections to be highly prevalent, at 71.0 %. These infections comprised both helminths and protozoa: Trichuris trichiura (50.8 %), Enterobius vermicularis (25.2 %), Ascaris lumbricoides (15.3 %), hookworm (11.6 %), Giardia lamblia (10.2 %), Endolimax nana (3.5 %), Entamoeba coli (2.7 %), and Blastocystis hominis (0.5 %). The environmental survey found a small number of houseflies near the accommodation to be positive for helminthic eggs (0.2 %), including A. lumbricoides, E. vermicularis, hookworms, Taenia spp., and minute intestinal flukes. Regarding the high prevalence of intestinal parasitic infections among children, it has been conjectured whether they were infected, along with their parents, during their daily lives before or after settling in Thailand. Intestinal parasites among immigrant children may involve a significant epidemiological impact, since immigrant children can serve as carriers and transmitters of disease

  1. Self-reported vaccination in the elderly

    Science.gov (United States)

    Reyes-Ortiz, Carlos; Borda, Miguel German; Arciniegas, Antonio

    2016-01-01

    Objectives: To determine the frequency of vaccination in older adults within the city of Bogotá and to estimate the association with sociodemographic and health factors. Methods: This is a secondary data analysis from the SABE-Bogotá Study, a cross-sectional population-based study that included a total of 2,000 persons aged 60 years. Weighted percentages for self-reported vaccination [influenza, pneumococcal, tetanus] were determined. The association between vaccination and covariates was evaluate by logistic regression models. Results: A total of 73.0% of respondents received influenza, 57.8% pneumococcal and 47.6% tetanus vaccine. Factors independently associated with vaccination included: 1- age (65-74 years had higher odds of receiving vaccinations, compared to 60-64 years); 2- socioeconomic status (SES) (higher SES had lower odds of having influenza and pneumococcal vaccines, compared to those with lower SES); 3- health insurance (those with contributive or subsidized health insurance had higher odds (between 3 and 5 times higher) of having vaccinations, compared to those with no insurance); 4- older adults with better functional status (greater Lawton scores) had increased odds for all vaccinations; 5- older adults with higher comorbidity had increased odds for influenza and pneumococcal vaccinations. Conclusion: Vaccination campaigns should be strengthened to increase vaccination coverage, especially in the group more reticent to vaccination or vulnerable to reach it such as the disabled elder. PMID:27226661

  2. MMR Vaccination and Febrile Seizures

    DEFF Research Database (Denmark)

    Vestergaard, Mogens; Hviid, Anders; Madsen, Kreesten Meldgaard;

    2004-01-01

    CONTEXT: The rate of febrile seizures increases following measles, mumps, and rubella (MMR) vaccination but it is unknown whether the rate varies according to personal or family history of seizures, perinatal factors, or socioeconomic status. Furthermore, little is known about the long-term outcome...... of febrile seizures following vaccination. OBJECTIVES: To estimate incidence rate ratios (RRs) and risk differences of febrile seizures following MMR vaccination within subgroups of children and to evaluate the clinical outcome of febrile seizures following vaccination. DESIGN, SETTING, AND PARTICIPANTS......: Incidence of first febrile seizure, recurrent febrile seizures, and subsequent epilepsy. RESULTS: A total of 439,251 children (82%) received MMR vaccination and 17,986 children developed febrile seizures at least once; 973 of these febrile seizures occurred within 2 weeks of MMR vaccination. The RR...

  3. Using Behavioral Risk Factor Data as a surveillance tool to monitor the prevalence of initiation, continuation and completion of Human Papilloma Virus vaccination in children

    Directory of Open Access Journals (Sweden)

    Gia Elise Barboza

    2016-06-01

    Full Text Available The Human Papilloma Virus (“HPV” is a common sexually transmitted disease that has infected approximately 79 million men and women in the United States alone. A vaccination is available but in order to be effective it must be received prior to becoming sexually active and recipients must complete a three-dose sequence. In this article we explore the predisposing, enabling and need-based factors associated with parents’ or guardians’ decision to have their child initiate, continue and complete the Human Papilloma Virus (HPV vaccine. The data file includes 5531 parents and guardians with presumptive knowledge regarding the number of HPV vaccination their child received. Data includes information on the child (e.g. child׳s age as well as the adult respondent (e.g. health insurance status. A smaller subset of the dataset along with the code to run the model are supplied with this article. The interpretation of these data can be found in the research article published by the authors in the Journal of Preventive Medicine in 2015 http://dx.doi.org/10.1016/j.ypmed.2016.01.010 [1].

  4. 北京市安定镇15岁以下人群水痘疫苗接种情况%Vaccination status of varicella among people under 15 years old in Anding town of Beijing

    Institute of Scientific and Technical Information of China (English)

    李秀合

    2012-01-01

    [Objective ] To understand the vaccination status of varicella among people under IS years old in Anding town of Beijing, provide the basis for improvement of varicella vaccination coverage rate and control of varicella epidemic. [ Methods] The data of varicella vaccine history of people under 15 years old in Anding town of Beijing collected from immunization program information system and emergency vaccination tables were analyzed descriptively. [Results] A total of 3 461 people were investigated, and the varicella vaccination coverage rate was 66. 57% (76. 62-34. 39%). The coverage rate in 1 to 7 year-old age group was high (71. 64%-76.62% ), and there was a significant difference in coverage rate among different age groups (P<0.01). The coverage rate of the local population and the immigrant population was 60.78% and 67.56% respectively, and the difference was statistically significant (P<0.01). The coverage rate of imported varicella vaccine increased with decreasing age, the coverage rate of students in the nurseries, the primary schools and the secondary schools was 77.72% , 63.84 % and 41.40% respectively, and the difference was statistically significant (P <0.01). The number of emergency vaccination accounted for 42. 52% of total vaccinated cases, and the number of emergency vaccination in students of the primary schools and the secondary schools respectively accounted for 52.67% and 94.76% of vaccinated cases in that age group. [ Conclusion] It is essential to increase publicity about varicella vaccination among people under IS years old in Anding town, and improve the coverage rate, so as to control the varicella outbreak in nurseries and schools.%目的 了解北京市安定镇15岁以下人群水痘疫苗接种情况,为提高水痘疫苗接种率和控制水痘疫情提供依据.方法 对北京市安定镇全部15岁以下人群通过免疫规划信息系统和查阅应急接种表,对水痘疫苗接种史进行描述性分析.结果 共调查3461人

  5. Early childbirth, health inputs and child mortality: recent evidence from Bangladesh

    OpenAIRE

    Maitra, Pushkar; Pal, Sarmistha

    2007-01-01

    This paper examines the relationship between early childbearing, parental use of health inputs and child mortality in Bangladesh. In order to account for the potential endogeneity of the age at birth and use of health inputs, (hospital delivery and child vaccination) in the child mortality regression, we jointly estimate mother’s age at childbirth, hospital delivery, child vaccination and child mortality taking into account of unobserved mother level heterogeneity. There is evidence of signif...

  6. Aluminiumallergi og granulomer som følge af vaccination hos børn

    DEFF Research Database (Denmark)

    Andersen, Rosa Marie Ø; Zachariae, Claus; Johansen, Jeanne Duus

    2015-01-01

    Vaccination with aluminium-adsorbed vaccines can induce aluminium allergy with persistent itching subcutaneous nodules at the injection site – vaccination granulomas. In this article we give an overview of childhood aluminium-adsorbed vaccines available in Denmark. Through literature studies we...... examine the incidence, the symptoms and the prognosis for the vaccination granulomas and the allergy. Finally we discuss the status in Denmark....

  7. Aluminiumallergi og granulomer som følge af vaccination hos børn

    DEFF Research Database (Denmark)

    Andersen, Rosa Marie O; Zachariae, Claus; Johansen, Jeanne Duus

    2014-01-01

    Vaccination with aluminium-adsorbed vaccines can induce aluminium allergy with persistent itching subcutaneous nodules at the injection site - vaccination granulomas. In this article we give an overview of childhood aluminium-adsorbed vaccines available in Denmark. Through literature studies we...... examine the incidence, the symptoms and the prognosis for the vaccination granulomas and the allergy. Finally we discuss the status in Denmark....

  8. Vaccination coverage and out-of-sequence vaccinations in rural Guinea-Bissau

    DEFF Research Database (Denmark)

    Hornshøj, Linda; Benn, Christine Stabell; Fernandes, Manuel;

    2012-01-01

    OBJECTIVE: The WHO aims for 90% coverage of the Expanded Program on Immunization (EPI), which in Guinea-Bissau included BCG vaccine at birth, three doses of diphtheria-tetanus-pertussis vaccine (DTP) and oral polio vaccine (OPV) at 6, 10 and 14 weeks and measles vaccine (MV) at 9 months when...... this study was conducted. The WHO assesses coverage by 12 months of age. The sequence of vaccines may have an effect on child mortality, but is not considered in official statistics or assessments of programme performance. We assessed vaccination coverage and frequency of out-of-sequence vaccinations by 12...... and 24 months of age. DESIGN: Observational cohort study. SETTING AND PARTICIPANTS: The Bandim Health Project's (BHP) rural Health and Demographic Surveillance site covers 258 randomly selected villages in all regions of Guinea-Bissau. Villages are visited biannually and vaccination cards inspected...

  9. Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study

    Directory of Open Access Journals (Sweden)

    Mirkuzie Alemnesh H

    2011-10-01

    Full Text Available Abstract Background Prevention of mother to child HIV transmission (PMTCT programmes have great potential to achieve virtual elimination of perinatal HIV transmission provided that PMTCT recommendations are properly followed. This study assessed mothers and infants adherence to medication regimen for PMTCT and the proportions of exposed infants who were followed up in the PMTCT programme. Methods A prospective cohort study was conducted among 282 HIV-positive mothers attending 15 health facilities in Addis Ababa, Ethiopia. Descriptive statistics, bivariate and mulitivariate logistic regression analyses were done. Results Of 282 mothers enrolled in the cohort, 232 (82%, 95% CI 77-86% initiated medication during pregnancy, 154 (64% initiated combined zidovudine (ZDV prophylaxis regimen while 78 (33% were initiated lifelong antiretroviral treatment (ART. In total, 171 (60%, 95% CI 55-66% mothers ingested medication during labour. Of the 221 live born infants (including two sets of twins, 191 (87%, 95% CI 81-90% ingested ZDV and single-dose nevirapine (sdNVP at birth. Of the 219 live births (twin births were counted once, 148 (68%, 95% CI 61-73% mother-infant pairs ingested their medication at birth. Medication ingested by mother-infant pairs at birth was significantly and independently associated with place of delivery. Mother-infant pairs attended in health facilities at birth were more likely (OR 6.7 95% CI 2.90-21.65 to ingest their medication than those who were attended at home. Overall, 189 (86%, 95% CI 80-90% infants were brought for first pentavalent vaccine and 115 (52%, 95% CI 45-58% for early infant diagnosis at six-weeks postpartum. Among the infants brought for early diagnosis, 71 (32%, 95% CI 26-39% had documented HIV test results and six (8.4% were HIV positive. Conclusions We found a progressive decline in medication adherence across the perinatal period. There is a big gap between mediation initiated during pregnancy and actually

  10. Smallpox vaccination and all-cause infectious disease hospitalization

    DEFF Research Database (Denmark)

    Sørup, Signe; Villumsen, Marie; Ravn, Henrik;

    2011-01-01

    There is growing evidence from observational studies and randomized trials in low-income countries that vaccinations have non-specific effects. Administration of live vaccines reduces overall child morbidity and mortality, presumably due to protection against non-targeted infections. In Denmark......, the live vaccine against smallpox was phased out in the 1970s due to the eradication of smallpox. We used the phasing-out period to investigate the effect of smallpox vaccination on the risk of hospitalization for infections....

  11. Effect of media use on mothers' vaccination of their children in sub-Saharan Africa.

    Science.gov (United States)

    Jung, Minsoo; Lin, Leesa; Viswanath, Kasisomayajula

    2015-05-21

    While several studies have examined the crucial role that parents' vaccination behaviors play in reducing disease spread and severity among children, few have evaluated the connection between parents' media use and their decision on whether or not to vaccinate their child, specifically in relation to the BCG (Bacillus Calmetter Guerin), DPT (Diptheria, Pertussis, Tetanus) polio, and measles vaccines. Media channels are a critical source of health information for parents, which is especially true in Sub-Saharan Africa, as there is often a dearth of local healthcare providers. The aim of this paper is to investigate the role that media use plays in a mothers' choice to vaccinate their infant children in sub-Saharan Africa, specifically focusing on whether media use is associated with socioeconomic status (SES) and a mothers' vaccination of their children. Cross-sectional data from the Demographic Health Surveys of 13 sub-Saharan countries (2004-2010) were pooled. A multivariate Poisson regression of 151,209 women was used to calculate adjusted relative ratios and 95% confidence intervals for the associations among SES, media use, and immunization. Education and wealth were found to be strongly and positively associated with vaccine-uptake behaviors. The effects of media use (radio and television) were found to be associated with the relationships between SES and vaccine uptake. However, it did not reduce the impact of SES on vaccination. These findings indicate that mass media may be an important tool for future efforts to reduce the health discrepancies between children from high- and low-socioeconomic backgrounds. Going forward, immunization strategies should include communication plans that will address and mitigate potential immunization disparities among parents of different SES backgrounds. PMID:25896379

  12. Effect of media use on mothers' vaccination of their children in sub-Saharan Africa.

    Science.gov (United States)

    Jung, Minsoo; Lin, Leesa; Viswanath, Kasisomayajula

    2015-05-21

    While several studies have examined the crucial role that parents' vaccination behaviors play in reducing disease spread and severity among children, few have evaluated the connection between parents' media use and their decision on whether or not to vaccinate their child, specifically in relation to the BCG (Bacillus Calmetter Guerin), DPT (Diptheria, Pertussis, Tetanus) polio, and measles vaccines. Media channels are a critical source of health information for parents, which is especially true in Sub-Saharan Africa, as there is often a dearth of local healthcare providers. The aim of this paper is to investigate the role that media use plays in a mothers' choice to vaccinate their infant children in sub-Saharan Africa, specifically focusing on whether media use is associated with socioeconomic status (SES) and a mothers' vaccination of their children. Cross-sectional data from the Demographic Health Surveys of 13 sub-Saharan countries (2004-2010) were pooled. A multivariate Poisson regression of 151,209 women was used to calculate adjusted relative ratios and 95% confidence intervals for the associations among SES, media use, and immunization. Education and wealth were found to be strongly and positively associated with vaccine-uptake behaviors. The effects of media use (radio and television) were found to be associated with the relationships between SES and vaccine uptake. However, it did not reduce the impact of SES on vaccination. These findings indicate that mass media may be an important tool for future efforts to reduce the health discrepancies between children from high- and low-socioeconomic backgrounds. Going forward, immunization strategies should include communication plans that will address and mitigate potential immunization disparities among parents of different SES backgrounds.

  13. Sibling Status Effects: Adult Expectations.

    Science.gov (United States)

    Baskett, Linda Musun

    1985-01-01

    This study attempted to determine what expectations or beliefs adults might hold about a child based on his or her sibling status alone. Ratings on 50 adjective pairs for each of three sibling status types, only, oldest, and youngest child, were assessed in relation to adult expectations, birth order, and parental status of rater. (Author/DST)

  14. Diphtheria Vaccination

    Science.gov (United States)

    ... children and adults - Tetanus-diphtheria-acellular Pertussis vaccine Diphtheria Vaccination Pronounced (dif-THEER-ee-a) Recommend on Facebook Tweet Share Compartir Diphtheria causes a thick covering in the back of ...

  15. 留守环境对农村独生子女心理健康状况的影响%Impact of Left-home Environment in Rural Area on Mental Health Status of the Only Child

    Institute of Scientific and Technical Information of China (English)

    徐丽华; 陈登峰; 傅文青; 阙墨春; 杨凤池; 徐美才

    2011-01-01

    目的:探讨留守环境对农村独生子女心理健康状况的影响.方法:采用中国中学生心理健康量表,对安徽省望江县某乡镇初级中学进行整群调查.结果:留守状况与独生状况在中学生强迫、抑郁因子上的交互作用显著(P<0.05),在B类留守儿童组,独生子女的得分高于非独生子女;留守环境可解释独生子女心理健康状况2.2%的方差变异(P=0.049),其中,以单亲外出的留守环境影响作用较大(β=0.225);留守环境对非独生子女心理健康状况的影响无统计学意义.结论:留守环境对独生子女心理健康状况的影响较为显著,以单亲外出的影响较大.%Objective: To study the impact of left-home environment in rural area on mental health status of the only child. Methods: Mental Health Inventory of Middle-School Students(MMHI-60) was adopted to investigate a whole junior middle school in a town of Wangjiang county in Anhui province. Results: The interaction effect on obsessive-compulsive and depression of left-home status and only child was significant (P<0.05); the only child scored higher than the non-only child in the group of one-parent-left-for-work students; left-home environment could explain 2.2% of the variation of mental health status of only child (p=0.049), thereinto, "one parent left for work" had more effects(β=0.225). Conclusion: Left-home environment in rural area has significant impact on the only child in mental health status, of which one-parent-left-for-work environment is more.

  16. Current Status and Challenges ofLeptospira Vaccine Development in China%我国钩端螺旋体疫苗的发展现状与挑战

    Institute of Scientific and Technical Information of China (English)

    徐颖华; 辛晓芳

    2015-01-01

    目的:总结分析我国钩端螺旋体的发展现状以及面临的问题与挑战。方法:根据国内外文献材料进行整理、归纳和分析。结果与结论:应解决钩体疫苗发展中面临的一些困境,进一步优化我国钩体疫苗,从而保证国家扩大计划免疫规划成功实施。%Objective: To analyze and summarize current status as well as problems and challenges of Leptospira vaccine development in China.Methods: The relevant domestic and international literatures were sorted, analyzed and summarized.Results and Conclusion: The problems in Leptospira vaccine development should be solved, and this vaccine product in China should be further optimized, so as to ensure the successful implementation of national program on expanded immunization.

  17. Pneumococcal Vaccines

    OpenAIRE

    Chen-Fang Ho; Tzou-Yien Lin

    2005-01-01

    Streptococcus pneumoniae is the leading bacterial pathogen of infectious diseases inchildren and adolescents. The 23-valent pneumococcal polysaccharide vaccine could preventinvasive pneumococcal infection with broader serotype coverage but still has some limitations.On the other hand, 7-valent pneumococcal conjugate vaccine has been shown todecrease cases of nasopharyngeal acquired S. pneumoniae vaccine serotypes and provedherd immunity. The safety and efficacy against vaccine serotype pneumo...

  18. ROTAVIRUS VACCINES

    OpenAIRE

    Kang G

    2006-01-01

    Rotavirus, the most common cause of severe diarrhea and a leading cause of mortality in children, has been a priority target for vaccine development for the past several years. The first rotavirus vaccine licensed in the United States was withdrawn because of an association of the vaccine with intussusception. However, the need for a vaccine is greatest in the developing world, because the benefits of preventing deaths due to rotavirus disease are substantially greater than the risk of intuss...

  19. Analysis on resource allocation status of three-level maternity and child care institutions in China in 2008%2008年全国三级妇幼保健机构资源配置状况分析

    Institute of Scientific and Technical Information of China (English)

    聂妍; 黄爱群; 罗荣; 牧童; 向梅; 潘晓平

    2011-01-01

    Objective: To analyze the resource allocation status of three - level maternity and child care institutions ( province, region, county) and the difference among different institutions, provide a basis for the construction and development of maternity and child care institutions in the course of new medical reform. Methods: The data of human resource allocation status of three - level maternity and child care institutions were collected by the national maternity and child hygiene institutions management information network and reporting system. Results: The proportion of health technicians of on- the- job workers in three- level maternity and child care institutions was about 80%; the ratios of doctor to nurse in maternity and child care institutions at provincial, regional and county levels were 0. 9, 1.3 and 2. 1,respectively; the proportions of undergraduate or above undergraduate educational levels of health technicians in three - level maternity and child care institutions were 48. 3%, 38. 1% and 17. 3%, respectively; the proportions of vice -high or above vice -high profession in three - level maternity and child care institutions were 16. 7%, 13. 4% and 4. 9%, respectively. More than 90% of the maternity and child care institutions at provincial and regional levels were indebted. Conclusion: The health care providers in maternity and child care institutions are lack, the staff establishment should be perfected; the quality of personnel in primary maternity and child care institutions is low, the construction of talented person troops should be enhanced; the development of maternity and child care institutions is unbalanced, the basic construction of primary maternity and child care institutions needs to be strengthened; the investment from government is inadequate, the responsibility of the government should be further clarified in public health services.%目的:分析全国省、地、县三级妇幼保健机构卫生资源的配置状况和

  20. A Comparison of Parent-child Communication of Students with Different Academic Status%不同学业成绩儿童的亲子沟通比较

    Institute of Scientific and Technical Information of China (English)

    池丽萍; 俞国良

    2012-01-01

    Previous literature has indicated that parent-child communication, e.g. , parents' communication ability, and the quality or style of the communication, potentially lead to their children's different status in academic achievement. However, there was not a clear distinction among these different levels or aspects of the communication in the existing research, which might lead to confusions of find- ings. Therefore, in the present study, we adopted a comprehensive Three-Level Model of Parent-Child Communication as a framework to measure and compare the parent-child communication of high, middle and low achieving students. In the model, the family is regarded as a system consisting of all family members, their relations and the interaction of the relations. Specifically, the model describes the parent-child communication on the following three levels : ( 1 ) the component level, measuring the communication ability of each family member, such as father, mother, and child; (:2) the relationship level, examining the quality of dyadic communication occurring be- tween father and child or mother and child; (3) the system level, emphasizing the relationship of mother-child and father-child commu- nlcatlons. A "parent-child communication scale" designed to measure the above three levels was applied in the present study to examine the parent-child communication of students with high, middle and low achievements. The results showed that : ( 1 ) high-achieving students' communication abilities in terms of initiative, clarity and sensitivity were better than those of low-achieving students ; the fathers of high- achieving students' outperform the fathers of low-achieving students in the clarity and openness of communication; (2) high-achieving students were at a higher level than low-achieving students in the quality of both relationship-oriented and problem-solving-oriented com- munication with their parents; (3) for high-achieving students, their mothers' and fathers

  1. Clinical Severity and Rotavirus Vaccination among Children Hospitalized for Acute Gastroenteritis in Belém, Northern Brazil.

    Science.gov (United States)

    Justino, Maria Cleonice A; Brasil, Patrícia; Abreu, Erika; Miranda, Yllen; Mascarenhas, Joana D'Arc P; Guerra, Sylvia F S; Linhares, Alexandre C

    2016-08-01

    In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (Rotarix™) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n = 252), partially vaccinated (n = 156) and fully vaccinated (n = 615) children. Very severe gastroenteritis (scored ≥ 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p = 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children.

  2. Household transmission of rotavirus in a community with rotavirus vaccination in Quininde, Ecuador.

    Directory of Open Access Journals (Sweden)

    Ben Lopman

    Full Text Available We studied the transmission of rotavirus infection in households in peri-urban Ecuador in the vaccination era.Stool samples were collected from household contacts of child rotavirus cases, diarrhea controls and healthy controls following presentation of the index child to health facilities. Rotavirus infection status of contacts was determined by RT-qPCR. We examined factors associated with transmissibility (index-case characteristics and susceptibility (household-contact characteristics.Amongst cases, diarrhea controls and healthy control household contacts, infection attack rates (iAR were 55%, 8% and 2%, (n = 137, 130, 137 respectively. iARs were higher from index cases with vomiting, and amongst siblings. Disease ARs were higher when the index child was <18 months and had vomiting, with household contact <10 years and those sharing a room with the index case being more susceptible. We found no evidence of asymptomatic infections leading to disease transmission.Transmission rates of rotavirus are high in households with an infected child, while background infections are rare. We have identified factors associated with transmission (vomiting/young age of index case and susceptibility (young age/sharing a room/being a sibling of the index case. Vaccination may lead to indirect benefits by averting episodes or reducing symptoms in vaccinees.

  3. Research Status of Common Invasive Fungal Vaccine%常见侵袭性真菌疫苗的研究现状

    Institute of Scientific and Technical Information of China (English)

    王立霞

    2012-01-01

    临床上存在抗肿瘤药物及抗生素滥用现象,使得条件致病性真菌感染疾病发病率升高,研究针时条件致病性真菌敏感的制剂-抗真菌药物及疫苗就显得十分重要.而临床应用抗真菌药物治疗的疗效不佳.出现较多耐药菌株,同时药物本身的毒副反应使患者无法耐受.因此,抗真菌治疗依然面临着严峻挑战.这无疑给研发真菌疫苗进行早期预防开辟了一条新的挑战途径.本文对真菌菌体疫苗、亚单位疫苗、DNA疫苗、树突状细胞与真菌疫苗以及含有失活基因的真菌疫苗进行综述.%Clinical antitumor antibiotics and drug abuse, increased incidence of opportunistic fungal infections, study of opportunistic fungal-sensitive preparation of antifungal drugs and vaccines are very important. Inefficacy of clinical application of antifungal drug therapy. More drug-resistant strains, and side effects of the drug itself so that patients could not be tolerated. Therefore, antifungal treatment is still faced with severe challenges. It has undoubtedly developed vaccine for early prevention of fungi has opened up a new and challenging way. This article on fungal cell vaccine and subunit vaccines, DNA vaccines, vaccine of dendritic cells and fungi as well as fungal vaccine containing the inactivation of genes for review.

  4. 20 CFR 410.213 - Duration of entitlement; child.

    Science.gov (United States)

    2010-04-01

    ... first occurs: (1) The child dies; (2) The child marries; (3) The child attains age 18 and, (i) Is not... the month in which he attains age 18; (4) If the child's entitlement is based on his status as a... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; child....

  5. Does biological relatedness affect child survival?

    OpenAIRE

    David Bishai; Heena Brahmbhatt; Ron Gray; Godfrey Kigozi; David Serwadda; Nelson Sewankambo; El Daw Suliman; Fred Wabwire-Mangen; Maria Wawer

    2003-01-01

    Objective: We studied child survival in Rakai, Uganda where many children are fostered out or orphaned. Methods: Biological relatedness is measured as the average of the Wright’s coefficients between each household member and the child. Instrumental variables for fostering include proportion of adult males in household, age and gender of household head. Control variables include SES, religion, polygyny, household size, child age, child birth size, and child HIV status. Results: Presence of ...

  6. Vaccines for leishmaniasis: from proteome to vaccine candidates.

    Science.gov (United States)

    Schroeder, Juliane; Aebischer, Toni

    2011-01-01

    Leishmania spp. cause a wide spectrum of tropical diseases which are threatening an estimated 350 million people around the globe. While in most cases non-fatal, the disease is associated with high morbidity, social stigmata and poverty. However, the most severe form visceral leishmaniasis can be fatal if left untreated. Chemotherapeutics are available but show high toxicity, costs and are prone to resistance development due to prolonged treatment periods. Healing is associated with a life-long resistance to re-infection and this argues for the feasibility of vaccination. However, despite much effort, no such vaccine has become available yet. Here, the status of vaccine development in this field is briefly summarized before the focus is set on the promise of reverse vaccinology for anti-Leishmania vaccine development in the post-genomic era. We report on our own experience with this approach using an instructive example of successful candidate vaccine antigen identification.

  7. Alternative administration routes and delivery technologies for polio vaccines.

    Science.gov (United States)

    Kraan, Heleen; van der Stel, Wanda; Kersten, Gideon; Amorij, Jean-Pierre

    2016-08-01

    Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery. PMID:26912100

  8. DNA vaccines

    Science.gov (United States)

    Gregersen, Jens-Peter

    2001-12-01

    Immunization by genes encoding immunogens, rather than with the immunogen itself, has opened up new possibilities for vaccine research and development and offers chances for new applications and indications for future vaccines. The underlying mechanisms of antigen processing, immune presentation and regulation of immune responses raise high expectations for new and more effective prophylactic or therapeutic vaccines, particularly for vaccines against chronic or persistent infectious diseases and tumors. Our current knowledge and experience of DNA vaccination is summarized and critically reviewed with particular attention to basic immunological mechanisms, the construction of plasmids, screening for protective immunogens to be encoded by these plasmids, modes of application, pharmacokinetics, safety and immunotoxicological aspects. DNA vaccines have the potential to accelerate the research phase of new vaccines and to improve the chances of success, since finding new immunogens with the desired properties is at least technically less demanding than for conventional vaccines. However, on the way to innovative vaccine products, several hurdles have to be overcome. The efficacy of DNA vaccines in humans appears to be much less than indicated by early studies in mice. Open questions remain concerning the persistence and distribution of inoculated plasmid DNA in vivo, its potential to express antigens inappropriately, or the potentially deleterious ability to insert genes into the host cell's genome. Furthermore, the possibility of inducing immunotolerance or autoimmune diseases also needs to be investigated more thoroughly, in order to arrive at a well-founded consensus, which justifies the widespread application of DNA vaccines in a healthy population.

  9. FLU VACCINATION

    CERN Document Server

    2007-01-01

    People working on the CERN site who wish to be vaccinated may go to the Infirmary (ground-floor, bldg. 57), with their vaccine, without a prior appointment. The vaccine can be reimbursed directly by Uniqa providing you attach the receipt and the prescription that you will receive from the Medical Service the day of your injection at the infirmary. Ideally, the vaccination should take place between 1st October and 30th November 2007 (preferably between 14:00 and 16:00). CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor. Medical Service

  10. Periodontal vaccine

    Directory of Open Access Journals (Sweden)

    Ranjan Malhotra

    2011-01-01

    Full Text Available Vaccine is the name applied generally to a substance of the nature of dead or attenuated living infectious material introduced into the body with the object of increasing its power to resist or get rid of a disease. Vaccines are generally prophylactic, i.e. they ameliorate the effects of future infection. One such vaccine considered here is the "Periodontal vaccine". Till date, no preventive modality exists for periodontal disease and treatment rendered is palliative. Thus, availability of periodontal vaccine would not only prevent and modulate periodontal disease, but also enhance the quality of life of people for whom periodontal treatment cannot be easily obtained. The aim of the research should be development of a multispecies vaccine targeting the four prime periodontal pathogens, viz. Porphyromonas gingivalis, T. forsythus, T. denticola and A. comitans. Success is still elusive in case of periodontal vaccine due to the complex etiopathogenesis of the disease.

  11. [About of vaccination].

    Science.gov (United States)

    Di Pietro, Maria Luisa; Refolo, Pietro; González-Melado, Fermín J

    2012-01-01

    The debate over compulsory or merely recommended vaccination remains open, albeit latent, in those countries that have mandatory vaccine schedules. Despite the advantages of preventive immunization from the point of medical, economic and social features, it's clear, in the current status of medical ethics, that the exercise of patient autonomy calls for personal responsibility in the election of treatments and, in fact, the vaccines. Therefore, it is necessary to change the simple idea of prevention as , characteristic of a in order to pass to a preventative medicine concept that will be able to support the achievement of moral attitudes towards achieving the good for the individual and for the community. This is only possible from a wherever is possible to present an alternative between mandatory vs. recommendation from the concept of that, with the help of a series of measures, could combine the effective protection for the whole community with the responsible exercise of the personal autonomy.

  12. Hepatitis Vaccines.

    Science.gov (United States)

    Ogholikhan, Sina; Schwarz, Kathleen B

    2016-01-01

    Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B globally. Given the lack of a hepatitis C vaccine, the many challenges facing the production of a hepatitis C vaccine will be shown, along with current and former vaccination trials. As there is no current FDA-approved hepatitis E vaccine, we will present vaccination data that is available in the rest of the world. Finally, we will discuss the existing challenges and questions facing future endeavors for each of the hepatitis viruses, with efforts continuing to focus on dramatically reducing the morbidity and mortality associated with these serious infections of the liver. PMID:26978406

  13. Hepatitis Vaccines

    Directory of Open Access Journals (Sweden)

    Sina Ogholikhan

    2016-03-01

    Full Text Available Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B globally. Given the lack of a hepatitis C vaccine, the many challenges facing the production of a hepatitis C vaccine will be shown, along with current and former vaccination trials. As there is no current FDA-approved hepatitis E vaccine, we will present vaccination data that is available in the rest of the world. Finally, we will discuss the existing challenges and questions facing future endeavors for each of the hepatitis viruses, with efforts continuing to focus on dramatically reducing the morbidity and mortality associated with these serious infections of the liver.

  14. Is early measles vaccination better than later measles vaccination?

    Science.gov (United States)

    Aaby, Peter; Martins, Cesário L; Ravn, Henrik; Rodrigues, Amabelia; Whittle, Hilton C; Benn, Christine S

    2015-01-01

    WHO recommends delaying measles vaccination (MV) until maternal antibody has waned. However, early MV may improve child survival by reducing mortality from conditions other than measles infection. We tested whether early MV improves child survival compared with later MV. We found 43 studies comparing measles-vaccinated and measles-unvaccinated children; however, only 16 studies had specific information that MV had been provided at 4-13 months of age, many before 9 months of age. In the 10 best studies (4 randomized trials and 6 observational studies) control children did not receive MV during follow-up. In eight of these studies the vaccine efficacy against death (VED) was 60% or more. In four studies with information on MV provided both before and after 12 months of age, the all-cause mortality reduction was significantly larger for children vaccinated in infancy (VED=74%; 95% CI 51-86%) than for children vaccinated after 12 months of age (VED=29%; CI 8-46%). Prevention of measles explained little of the reduction in mortality. In five studies with information on measles infection, VED was 67% (51-78%) and when measles deaths were excluded, VED was only reduced to 65% (47-77%). One natural experiment compared MV at 4-8 months versus MV at 9-11 months of age and found significantly lower all-cause mortality with early vaccination, the difference being 39% (8-60%). Child mortality may be reduced if MV is given earlier than currently recommended by international organizations.

  15. 人乳头瘤病毒预防性疫苗的研究进展和应用现状%Review for progress and current status of human papillomavirus prophylactic vaccine

    Institute of Scientific and Technical Information of China (English)

    李韵冰; 宋硕; 王大宁; 李智海; 夏宁邵; 李少伟

    2016-01-01

    高危型人乳头瘤病毒( human papilloma virus,HPV)感染被证实是诱发女性宫颈癌的主要原因。宫颈癌已成为继乳腺癌之后世界范围内严重威胁妇女健康的疾病。目前宫颈癌治疗效果不佳,因此预防HPV感染尤为重要。国外已上市的3种HPV预防性疫苗显示出良好的安全性和有效性,但由于生产成本和售价较高,阻碍了其在发展中国家和经济较落后的地区推广应用。目前,这些疫苗尚未在我国上市,本文综述了HPV疫苗的研究进展和应用现状,为即将在我国上市的HPV疫苗提供信息。%Persistant infection of high-risk human papillomavirus (HPV) is the primary cause leading to cervical cancer, which is ranked as second cancer threatening the health of women following breast cancer.Development of HPV vaccine is very important because there is no effective therapeutics for cervical cancer.Three currently licensed HPV vaccines based on major capsid protein L1 in the foreign market confered good safety and efficacy in clinical trials, but the current price is expensive due to high cost, which limits the wide application in developing countries.So far, the vaccines have not been launced in China market.Here, we review the progress and the current status of the HPV vaccine, which will attract the readers’ interest on the forthcoming emergence of HPV vaccine in China.

  16. 大连市2011年基层预防接种人员现状分析%Analysis primary prevention of vaccinators of the status in Dalian City in 2011, Dalian City in 2011

    Institute of Scientific and Technical Information of China (English)

    林茜; 贾秀岩; 肖丹

    2013-01-01

    目的了解我市基层预防接种人员基本情况,为建设一支高素质、适应预防接种服务现状的免疫接种队伍提供参考依据。方法对全市范围内预防接种人员按照设计好的调查表进行调查。结果调查预防接种人员2869人,以女性为主(1191人),占66.61%,平均年龄43岁,文化程度以高中及中专学历为主(1803人),占62.84%,职称以初级为主(1785人),占62.22%。不同地区预防接种人员综合素质存在不同程度的差异。结论应及时调整预防接种人员结构,严格准入制度,强化业务培训和指导,形成激励机制,建立起一支高素质的、可持续发展的预防接种队伍。%Objective] To understand the status of the staff engaged in preventive vaccination,provide scientific basis for the establishment of the team with high quality.[Methods] Investigate citywide vaccination staff according to the design of the questionnaire.[Results]The average age of the 2869 people surveyed is 43-year-old.66.61%(1191) of the staff were female.62.84%(1803) of the staff were at the education level of the secondary and high school education.62.22%(1785) of the staff have the primary titles.The overall quality of the vaccinators is different in different regions.[Conclusion] We should pay attention to the adjustments of vaccination staff,set up the mechanism for staff of entering and incentive,strengthen vocational training and guidance.Establish a high quality and sustainable development of the vaccination team.

  17. Timeliness vaccination of measles containing vaccine and barriers to vaccination among migrant children in East China.

    Directory of Open Access Journals (Sweden)

    Yu Hu

    Full Text Available BACKGROUND: The reported coverage rates of first and second doses of measles containing vaccine (MCV are almost 95% in China, while measles cases are constantly being reported. This study evaluated the vaccine coverage, timeliness, and barriers to immunization of MCV1 and MCV2 in children aged from 8-48 months. METHODS: We assessed 718 children aged 8-48 months, of which 499 children aged 18-48 months in September 2011. Face to face interviews were administered with children's mothers to estimate MCV1 and MCV2 coverage rate, its timeliness and barriers to vaccine uptake. RESULTS: The coverage rates were 76.9% for MCV1 and 44.7% for MCV2 in average. Only 47.5% of surveyed children received the MCV1 timely, which postpone vaccination by up to one month beyond the stipulated age of 8 months. Even if coverage thus improves with time, postponed vaccination adds to the pool of unprotected children in the population. Being unaware of the necessity for vaccination and its schedule, misunderstanding of side-effect of vaccine, and child being sick during the recommended vaccination period were significant preventive factors for both MCV1 and MCV2 vaccination. Having multiple children, mother's education level, household income and children with working mothers were significantly associated with delayed or missing MCV1 immunization. CONCLUSIONS: To avoid future outbreaks, it is crucial to attain high coverage levels by timely vaccination, thus, accurate information should be delivered and a systematic approach should be targeted to high-risk groups.

  18. Ethnicity and Child Health in Northern Tanzania: Maasai Pastoralists Are Disadvantaged Compared to Neighbouring Ethnic Groups

    Science.gov (United States)

    Lawson, David W.; Borgerhoff Mulder, Monique; Ghiselli, Margherita E.; Ngadaya, Esther; Ngowi, Bernard; Mfinanga, Sayoki G. M.; Hartwig, Kari; James, Susan

    2014-01-01

    The Maasai of northern Tanzania, a semi-nomadic ethnic group predominantly reliant on pastoralism, face a number of challenges anticipated to have negative impacts on child health, including marginalisation, vulnerabilities to drought, substandard service provision and on-going land grabbing conflicts. Yet, stemming from a lack of appropriate national survey data, no large-scale comparative study of Maasai child health has been conducted. Savannas Forever Tanzania surveyed the health of over 3500 children from 56 villages in northern Tanzania between 2009 and 2011. The major ethnic groups sampled were the Maasai, Sukuma, Rangi, and the Meru. Using multilevel regression we compare each ethnic group on the basis of (i) measurements of child health, including anthropometric indicators of nutritional status and self-reported incidence of disease; and (ii) important proximate determinants of child health, including food insecurity, diet, breastfeeding behaviour and vaccination coverage. We then (iii) contrast households among the Maasai by the extent to which subsistence is reliant on livestock herding. Measures of both child nutritional status and disease confirm that the Maasai are substantially disadvantaged compared to neighbouring ethnic groups, Meru are relatively advantaged, and Rangi and Sukuma intermediate in most comparisons. However, Maasai children were less likely to report malaria and worm infections. Food insecurity was high throughout the study site, but particularly severe for the Maasai, and reflected in lower dietary intake of carbohydrate-rich staple foods, and fruits and vegetables. Breastfeeding was extended in the Maasai, despite higher reported consumption of cow's milk, a potential weaning food. Vaccination coverage was lowest in Maasai and Sukuma. Maasai who rely primarily on livestock herding showed signs of further disadvantage compared to Maasai relying primarily on agriculture. We discuss the potential ecological, socioeconomic, demographic

  19. Ethnicity and child health in northern Tanzania: Maasai pastoralists are disadvantaged compared to neighbouring ethnic groups.

    Directory of Open Access Journals (Sweden)

    David W Lawson

    Full Text Available The Maasai of northern Tanzania, a semi-nomadic ethnic group predominantly reliant on pastoralism, face a number of challenges anticipated to have negative impacts on child health, including marginalisation, vulnerabilities to drought, substandard service provision and on-going land grabbing conflicts. Yet, stemming from a lack of appropriate national survey data, no large-scale comparative study of Maasai child health has been conducted. Savannas Forever Tanzania surveyed the health of over 3500 children from 56 villages in northern Tanzania between 2009 and 2011. The major ethnic groups sampled were the Maasai, Sukuma, Rangi, and the Meru. Using multilevel regression we compare each ethnic group on the basis of (i measurements of child health, including anthropometric indicators of nutritional status and self-reported incidence of disease; and (ii important proximate determinants of child health, including food insecurity, diet, breastfeeding behaviour and vaccination coverage. We then (iii contrast households among the Maasai by the extent to which subsistence is reliant on livestock herding. Measures of both child nutritional status and disease confirm that the Maasai are substantially disadvantaged compared to neighbouring ethnic groups, Meru are relatively advantaged, and Rangi and Sukuma intermediate in most comparisons. However, Maasai children were less likely to report malaria and worm infections. Food insecurity was high throughout the study site, but particularly severe for the Maasai, and reflected in lower dietary intake of carbohydrate-rich staple foods, and fruits and vegetables. Breastfeeding was extended in the Maasai, despite higher reported consumption of cow's milk, a potential weaning food. Vaccination coverage was lowest in Maasai and Sukuma. Maasai who rely primarily on livestock herding showed signs of further disadvantage compared to Maasai relying primarily on agriculture. We discuss the potential ecological

  20. Flu Vaccination

    CERN Multimedia

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical service

  1. Flu Vaccination

    CERN Document Server

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical Service

  2. Flu vaccination

    CERN Multimedia

    CERN Medical Service

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor.CERN Medical Service

  3. FLU VACCINATION

    CERN Multimedia

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical Service

  4. The effects of anti-vaccine conspiracy theories on vaccination intentions.

    Science.gov (United States)

    Jolley, Daniel; Douglas, Karen M

    2014-01-01

    The current studies investigated the potential impact of anti-vaccine conspiracy beliefs, and exposure to anti-vaccine conspiracy theories, on vaccination intentions. In Study 1, British parents completed a questionnaire measuring beliefs in anti-vaccine conspiracy theories and the likelihood that they would have a fictitious child vaccinated. Results revealed a significant negative relationship between anti-vaccine conspiracy beliefs and vaccination intentions. This effect was mediated by the perceived dangers of vaccines, and feelings of powerlessness, disillusionment and mistrust in authorities. In Study 2, participants were exposed to information that either supported or refuted anti-vaccine conspiracy theories, or a control condition. Results revealed that participants who had been exposed to material supporting anti-vaccine conspiracy theories showed less intention to vaccinate than those in the anti-conspiracy condition or controls. This effect was mediated by the same variables as in Study 1. These findings point to the potentially detrimental consequences of anti-vaccine conspiracy theories, and highlight their potential role in shaping health-related behaviors.

  5. The effects of anti-vaccine conspiracy theories on vaccination intentions.

    Directory of Open Access Journals (Sweden)

    Daniel Jolley

    Full Text Available The current studies investigated the potential impact of anti-vaccine conspiracy beliefs, and exposure to anti-vaccine conspiracy theories, on vaccination intentions. In Study 1, British parents completed a questionnaire measuring beliefs in anti-vaccine conspiracy theories and the likelihood that they would have a fictitious child vaccinated. Results revealed a significant negative relationship between anti-vaccine conspiracy beliefs and vaccination intentions. This effect was mediated by the perceived dangers of vaccines, and feelings of powerlessness, disillusionment and mistrust in authorities. In Study 2, participants were exposed to information that either supported or refuted anti-vaccine conspiracy theories, or a control condition. Results revealed that participants who had been exposed to material supporting anti-vaccine conspiracy theories showed less intention to vaccinate than those in the anti-conspiracy condition or controls. This effect was mediated by the same variables as in Study 1. These findings point to the potentially detrimental consequences of anti-vaccine conspiracy theories, and highlight their potential role in shaping health-related behaviors.

  6. The effects of anti-vaccine conspiracy theories on vaccination intentions.

    Science.gov (United States)

    Jolley, Daniel; Douglas, Karen M

    2014-01-01

    The current studies investigated the potential impact of anti-vaccine conspiracy beliefs, and exposure to anti-vaccine conspiracy theories, on vaccination intentions. In Study 1, British parents completed a questionnaire measuring beliefs in anti-vaccine conspiracy theories and the likelihood that they would have a fictitious child vaccinated. Results revealed a significant negative relationship between anti-vaccine conspiracy beliefs and vaccination intentions. This effect was mediated by the perceived dangers of vaccines, and feelings of powerlessness, disillusionment and mistrust in authorities. In Study 2, participants were exposed to information that either supported or refuted anti-vaccine conspiracy theories, or a control condition. Results revealed that participants who had been exposed to material supporting anti-vaccine conspiracy theories showed less intention to vaccinate than those in the anti-conspiracy condition or controls. This effect was mediated by the same variables as in Study 1. These findings point to the potentially detrimental consequences of anti-vaccine conspiracy theories, and highlight their potential role in shaping health-related behaviors. PMID:24586574

  7. Hepatitis B Vaccine

    Science.gov (United States)

    ... as a combination product containing Hepatitis A Vaccine, Hepatitis B Vaccine) ... Hepatitis B vaccine: Why get vaccinated?Hepatitis B vaccine can prevent hepatitis B, and the serious consequences of hepatitis ...

  8. [Which vaccinations for which travel-destination?].

    Science.gov (United States)

    De Crom, Susan; Veit, Olivia; Hatz, Christoph

    2016-01-01

    Several vaccinations are recommended to protect international travellers, especially to tropical countries, from diseases in other parts of the world. Firstly, the routine schedule of childhood vaccinations and booster shots according to the Swiss immunisation programme should be checked, updated or even completed. Additional vaccinations against hepatitis A and B, typhoid fever, poliomyelitis, rabies or Japanese encephalitis may be recommended. This will depend on a number of factors including the exact destination and route (developing countries, rural areas), planned activities (backpacker, family visit, business trip), duration of travel, season, age of the traveller and current health status including the current medication and previous vaccinations. Some vaccinations, such as yellow fever, may be required for travellers to certain countries and the international certificate of vaccination may even be required when entering a country from another country where yellow fever is endemic. The international certificate of vaccination (or a letter of exemption when appropriate) is considered valid only if it is administered by an approved vaccination centre. Furthermore, the meningococcal vaccination (A, C, W, Y) is required for pilgrims to Saudi Arabia. It is recommended to start the vaccinations four to six weeks before departure to ensure enough time to administer all the necessary doses for an adequate immune response. All commonly used vaccines can be administered on the same day. The basic health insurance does not usually cover travel vaccines. PMID:27268450

  9. [HPV vaccination].

    Science.gov (United States)

    Stronski Huwiler, Susanne; Spaar, Anne

    2016-01-01

    Human Papilloma Viruses are associated with genital carcinoma (of the cervix, anus, vulva, vagina and the penis) as well as with non-genital carcinoma (oropharyngeal carcinoma) and genital warts. In Switzerland two highly efficient and safe vaccines are available. The safety of these vaccines has been repeatedly subject of controversial discussions, however so far post marketing surveillance has always been able to confirm the safety. In Switzerland girls and young women have been offered the HPV vaccination within cantonal programmes since 2008. 2015 the recommendation for the HPV-vaccination for boys and young men was issued, and starting July 1, 2016 they as well will be offered vaccination free of charge within the cantonal programmes. This article discusses the burden of disease, efficacy and safety of the vaccines and presents facts which are important for vaccinating these young people. Specifically, aspects of the decisional capacity of adolescents to consent to the vaccination are presented. Finally, the future perspective with a focus on a new vaccine with an enlarged spectrum of HPV-types is discussed. PMID:27268446

  10. Parent-child relationship status and self-congruence in college students%亲子关系与大学生自我和谐的相关研究

    Institute of Scientific and Technical Information of China (English)

    陶甜美; 刘新民; 金明琦

    2012-01-01

    目的:了解大学生自我和谐的现状,探讨亲子关系与大学生自我和谐之间的相关性.方法:采用亲子关系调查问卷和自我和谐量表(SCCS)对某医学院260名大学生进行问卷调查,对数据进行独立样本t检验、方差分析和积差相关分析.结果:①大学生自我和谐状况在性别上无显著性差异,独生子女与非独生子女在自我刻板性得分上有显著性差异.②大二年级与大一、大三、大四年级在自我与经验不和谐得分、自我灵活性得分、自我刻板性得分和自我和谐总分上有显著性差异.③亲子关系调查问卷的6个维度与自我和谐量表3个维度有显著性相关.结论:大学生的亲子关系与其自我和谐状况存在相关性.%Objective: To investigate the self-congruence status in college students and the association of this factor with parent-child relationship. Methods:Two hundred and sixty medical college students are surveyed u-sing questionnaire of parent-child relationship questionnaire and Self Consistency and Congruence Scale ( SCCS ), and the data collected were analyzed on basis of independent sample by t-test, variance analysis and product-moment correlation analysis. Results: The self-congruence status in college students had no significant difference concerning the sexes, but had striking difference regarding the stiffness of self-consistency between students from one-child family and those with than one child. The scores in freshmen and sophomore differed significantly from the junior and senior regarding the factors of the inconsistency between self and experience, flexibility of self-consistency, stiffness of self-consistency and total scoring on self-congruence. The six components on the parent-child relationship questionnaire were significantly associated with the three components on SCCS. Conclusion:The parent-child relationship is associated with the a-chievement of self-congruence in college students.

  11. Accelerating improvements in nutritional and health status of young children in the Sahel region of Sub-Saharan Africa: review of international guidelines on infant and young child feeding and nutrition.

    Science.gov (United States)

    Wuehler, Sara E; Hess, Sonja Y; Brown, Kenneth H

    2011-04-01

    The United Nations Convention on the Rights of the Child holds governments responsible to ensure children's right to the highest attainable standard of health by providing breastfeeding support, and access to nutritious foods, appropriate health care, and clean drinking water. International experts have identified key child care practices and programmatic activities that are proven to be effective at reducing infant and young child undernutrition, morbidity, and mortality. Nevertheless, progress towards reducing the prevalence of undernutrition has been sporadic across countries of the Sahel sub-region of Sub-Saharan Africa. In view of this uneven progress, a working group of international agencies was convened to 'Reposition children's right to adequate nutrition in the Sahel.' The first step towards this goal was to organize a situational analysis of the legislative, research, and programmatic activities related to infant and young child nutrition (IYCN) in six countries of the sub-region: Burkina Faso, Chad, Mali, Mauritania, Niger, and Senegal. The purposes of this introductory paper are to review current information concerning the nutritional and health status of infants and young children in the Sahel and to summarize international guidelines on optimal IYCN practices. These guidelines were used in completing the above-mentioned situational analyses and encompass specific recommendations on: (i) breastfeeding (introduction within the first hour after birth, exclusivity to 6 months, continuation to at least 24 months); (ii) complementary feeding (introduction at 6 months, use of nutrient dense foods, adequate frequency and consistency, and responsive feeding); (iii) prevention and/or treatment of micronutrient deficiencies (vitamin A, zinc, iron and anaemia, and iodine); (iv) prevention and/or treatment of acute malnutrition; (v) feeding practices adapted to the maternal situation to reduce mother-to-child transmission of HIV; (vi) activities to ensure food

  12. Determinants of European parents' decision on the vaccination of their children against measles, mumps and rubella: A systematic review and meta-analysis.

    Science.gov (United States)

    Tabacchi, Garden; Costantino, Claudio; Napoli, Giuseppe; Marchese, Valentina; Cracchiolo, Manuela; Casuccio, Alessandra; Vitale, Francesco; On Behalf Of The Esculapio Working Group

    2016-07-01

    Low measles, mumps and rubella (MMR) immunization levels in European children highlight the importance of identifying determinants of parental vaccine uptake to implement policies for increasing vaccine compliance. The aim of this paper is to identify the main factors associated with partial and full MMR vaccination uptake in European parents, and combine the different studies to obtain overall quantitative measures. This activity is included within the ESCULAPIO project, funded by the Italian Ministry of Health. ORs and CIs were extracted, sources of heterogeneity explored and publication bias assessed. Forty-five papers were retrieved for the qualitative study, 26 of which were included in the meta-analysis. The following factors were associated with lower MMR vaccine uptake: misleading knowledge, beliefs and perceptions on vaccines (OR 0.57, CI 0.37-0.87); negative attitudes and behaviors toward vaccination (OR 0.71, CI 0.52-0.98); demographic characteristics, such as different ethnicity in Southern populations (OR 0.44, CI 0.31-0.61), higher child's age (OR 0.80, CI 0.76-0.85); low socio-economic status (OR 0.64, CI 0.51-0.80), especially low income (OR 0.39, CI 0.25-0.60) and education (OR 0.64, CI 0.48-0.84), high number of children (OR 0.54, CI 0.42-0.69), irregular marital status (OR 0.80, CI 0.66-0.96). The factors explaining heterogeneity were country location, administration modality, collection setting and responses reported on MMR alone or in combination. Findings from this study suggest policy makers to focus communication strategies on providing better knowledge, correct beliefs and perceptions on vaccines, and improving attitudes and behaviors in parents; and to target policies to people of ethnic minority from Southern Europe, low educated and deprived, with higher number of children and non-married marital status. PMID:27163657

  13. Pulmonary Vaccine Delivery : A Realistic Approach?

    NARCIS (Netherlands)

    Tonnis, Wouter F; Kersten, Gideon F; Frijlink, Henderik W; Hinrichs, Wouter L J; de Boer, Anne H; Amorij, Jean-Pierre

    2012-01-01

    Pulmonary vaccine delivery has gained increasing attention during the last decade because this vaccination method combines potential advantages such as the fact that it omits the use of needles and may elicit immunity at the port of entry for many pathogens. In this review the current status of pulm

  14. Study on hepatitis B vaccine and HBIG's effect on preventing HBV transmission from mother to child during pregnancy%乙肝疫苗和免疫球蛋白阻断乙肝母婴传播效果研究

    Institute of Scientific and Technical Information of China (English)

    宋婷婷; 单芙香; 程锦泉; 尹平

    2011-01-01

    positve HBsAg (14.29 %/2.94 % ), HBeAg and HBcAb compared with those with mothers carrying positive HBsAg and HBcAb (P<0.05). The positive rates of HBsAg in infants whose mothers had been inoculated with HBIG or not during pregnancy were 8.57 96 and 7.77 % respectively, without significant difference between them (P >0.05). There was no significant difference for the positive rates of HBsAg in infants whose mothers choosing cesarean section (9.68%) or natural delivery (3.08%). Regarding different feeding methods, there were also no significant difference found for the positive rates of HBsAg in infants (6.45%/7.69% ). Conclusions In current study, inoculating hepatitis B vaccine and HBIG in infants have significant effects on blocking HBV mother-to-child transmission. The blocking effect is significantly associated with the infection status of HBV in mothers. No relationship was found between the blocking effect and the situation of inoculating HBIG during pregnancy, delivery methods and feeding methods.

  15. Progress towards the child mortality millennium development goal in urban sub-Saharan Africa: the dynamics of population growth, immunization, and access to clean water

    Directory of Open Access Journals (Sweden)

    Madise Nyovani

    2007-08-01

    Full Text Available Abstract Background Improvements in child survival have been very poor in sub-Saharan Africa (SSA. Since the 1990s, declines in child mortality have reversed in many countries in the region, while in others, they have either slowed or stalled, making it improbable that the target of reducing child mortality by two thirds by 2015 will be reached. This paper highlights the implications of urban population growth and access to health and social services on progress in achieving MDG 4. Specifically, it examines trends in childhood mortality in SSA in relation to urban population growth, vaccination coverage and access to safe drinking water. Methods Correlation methods are used to analyze national-level data from the Demographic and Health Surveys and from the United Nations. The analysis is complemented by case studies on intra-urban health differences in Kenya and Zambia. Results Only five of the 22 countries included in the study have recorded declines in urban child mortality that are in line with the MDG target of about 4% per year; five others have recorded an increase; and the 12 remaining countries witnessed only minimal decline. More rapid rate of urban population growth is associated with negative trend in access to safe drinking water and in vaccination coverage, and ultimately to increasing or timid declines in child mortality. There is evidence of intra-urban disparities in child health in some countries like Kenya and Zambia. Conclusion Failing to appropriately target the growing sub-group of the urban poor and improve their living conditions and health status – which is an MDG target itself – may result in lack of improvement on national indicators of health. Sustained expansion of potable water supplies and vaccination coverage among the disadvantaged urban dwellers should be given priority in the efforts to achieve the child mortality MDG in SSA.

  16. Child Abuse

    Science.gov (United States)

    ... or puts a child at risk of harm. Child abuse can be physical, sexual or emotional. Neglect, or not providing for a child's needs, is also a form of abuse. Most abused children suffer greater emotional than physical damage. An abused child may become ...

  17. Vaccines and autism: a tale of shifting hypotheses.

    Science.gov (United States)

    Gerber, Jeffrey S; Offit, Paul A

    2009-02-15

    Although child vaccination rates remain high, some parental concern persists that vaccines might cause autism. Three specific hypotheses have been proposed: (1) the combination measles-mumps-rubella vaccine causes autism by damaging the intestinal lining, which allows the entrance of encephalopathic proteins; (2) thimerosal, an ethylmercury-containing preservative in some vaccines, is toxic to the central nervous system; and (3) the simultaneous administration of multiple vaccines overwhelms or weakens the immune system. We will discuss the genesis of each of these theories and review the relevant epidemiological evidence.

  18. Rotavirus Vaccine

    Science.gov (United States)

    Why get vaccinated?Rotavirus is a virus that causes diarrhea, mostly in babies and young children. The diarrhea can be severe, and lead ... and fever are also common in babies with rotavirus.Before rotavirus vaccine, rotavirus disease was a common ...

  19. Does biological relatedness affect child survival?

    Directory of Open Access Journals (Sweden)

    2003-05-01

    Full Text Available Objective: We studied child survival in Rakai, Uganda where many children are fostered out or orphaned. Methods: Biological relatedness is measured as the average of the Wright's coefficients between each household member and the child. Instrumental variables for fostering include proportion of adult males in household, age and gender of household head. Control variables include SES, religion, polygyny, household size, child age, child birth size, and child HIV status. Results: Presence of both parents in the household increased the odds of survival by 28%. After controlling for the endogeneity of child placement decisions in a multivariate model we found that lower biological relatedness of a child was associated with statistically significant reductions in child survival. The effects of biological relatedness on child survival tend to be stronger for both HIV- and HIV+ children of HIV+ mothers. Conclusions: Reductions in the numbers of close relatives caring for children of HIV+ mothers reduce child survival.

  20. Estimating rotavirus vaccine effectiveness in Japan using a screening method

    Science.gov (United States)

    Araki, Kaoru; Hara, Megumi; Sakanishi, Yuta; Shimanoe, Chisato; Nishida, Yuichiro; Matsuo, Muneaki; Tanaka, Keitaro

    2016-01-01

    abstract Rotavirus gastroenteritis is a highly contagious, acute viral disease that imposes a significant health burden worldwide. In Japan, rotavirus vaccines have been commercially available since 2011 for voluntary vaccination, but vaccine coverage and effectiveness have not been evaluated. In the absence of a vaccination registry in Japan, vaccination coverage in the general population was estimated according to the number of vaccines supplied by the manufacturer, the number of children who received financial support for vaccination, and the size of the target population. Patients with rotavirus gastroenteritis were identified by reviewing the medical records of all children who consulted 6 major hospitals in Saga Prefecture with gastroenteritis symptoms. Vaccination status among these patients was investigated by reviewing their medical records or interviewing their guardians by telephone. Vaccine effectiveness was determined using a screening method. Vaccination coverage increased with time, and it was 2-times higher in municipalities where the vaccination fee was supported. In the 2012/13 season, vaccination coverage in Saga Prefecture was 14.9% whereas the proportion of patients vaccinated was 5.1% among those with clinically diagnosed rotavirus gastroenteritis and 1.9% among those hospitalized for rotavirus gastroenteritis. Thus, vaccine effectiveness was estimated as 69.5% and 88.8%, respectively. This is the first study to evaluate rotavirus vaccination coverage and effectiveness in Japan since vaccination began. PMID:26680277

  1. Estimating rotavirus vaccine effectiveness in Japan using a screening method.

    Science.gov (United States)

    Araki, Kaoru; Hara, Megumi; Sakanishi, Yuta; Shimanoe, Chisato; Nishida, Yuichiro; Matsuo, Muneaki; Tanaka, Keitaro

    2016-05-01

    Rotavirus gastroenteritis is a highly contagious, acute viral disease that imposes a significant health burden worldwide. In Japan, rotavirus vaccines have been commercially available since 2011 for voluntary vaccination, but vaccine coverage and effectiveness have not been evaluated. In the absence of a vaccination registry in Japan, vaccination coverage in the general population was estimated according to the number of vaccines supplied by the manufacturer, the number of children who received financial support for vaccination, and the size of the target population. Patients with rotavirus gastroenteritis were identified by reviewing the medical records of all children who consulted 6 major hospitals in Saga Prefecture with gastroenteritis symptoms. Vaccination status among these patients was investigated by reviewing their medical records or interviewing their guardians by telephone. Vaccine effectiveness was determined using a screening method. Vaccination coverage increased with time, and it was 2-times higher in municipalities where the vaccination fee was supported. In the 2012/13 season, vaccination coverage in Saga Prefecture was 14.9% whereas the proportion of patients vaccinated was 5.1% among those with clinically diagnosed rotavirus gastroenteritis and 1.9% among those hospitalized for rotavirus gastroenteritis. Thus, vaccine effectiveness was estimated as 69.5% and 88.8%, respectively. This is the first study to evaluate rotavirus vaccination coverage and effectiveness in Japan since vaccination began. PMID:26680277

  2. Urban poverty and utilization of maternal and child health care services in India.

    Science.gov (United States)

    Prakash, Ravi; Kumar, Abhishek

    2013-07-01

    Drawing upon data from the third round of the National Family Health Survey (NFHS-3) conducted in India during 2005-06, this study compares the utilization of selected maternal and child health care services between the urban poor and non-poor in India and across selected Indian states. A wealth index was created, separately for urban areas, using Principal Component Analysis to identify the urban poor. The findings suggest that the indicators of maternal and child health care are worse among the urban poor than in their non-poor counterparts. For instance, the levels of antenatal care, safe delivery and childhood vaccinations are much lower among the urban poor than non-poor, especially in socioeconomically disadvantageous states. Among all the maternal and child health care indicators, the non-poor/poor difference is most pronounced for delivery care in the country and across the states. Other than poverty status, utilization of antenatal services by mothers increases the chances of safe delivery and child immunization at both national and sub-national levels. The poverty status of the household emerged as a significant barrier to utilization of health care services in urban India.

  3. Child Wasting in Emergency Pockets: A Meta-Analysis of Small-Scale Surveys from Ethiopia.

    Science.gov (United States)

    Altare, Chiara; Delbiso, Tefera Darge; Guha-Sapir, Debarati

    2016-02-01

    Child undernutrition is a major public health concern in Ethiopia (stunting national prevalence: 44%; wasting: 10%), despite the overall improvement in child health status during the last decade. Hundreds of small-scale surveys are conducted in Ethiopia's emergency pockets under ENCU's supervision. We reviewed the evidence from small-scale surveys conducted between 2008 and 2013 with two objectives: to provide a summary estimate of wasting prevalence from emergency pockets and to examine reasons for variation in prevalence estimates. We created a dataset by combining data from the Complex Emergency Database, the Famine Early Warning System Network and the Armed Conflict Location Event Data. We conducted a meta-analysis of small-scale surveys using a random effects model with known within-study heterogeneity. The influence of survey covariates on estimated prevalence was investigated with meta-regression techniques. We included 158 surveys in the analysis. A high degree of heterogeneity among surveys was observed. The overall estimate of wasting prevalence was 10.6% (95% CI 9.8-11.4), with differences among regions and between residents and refugees. Meta-regression results showed that vaccination coverage, child mortality, diarrhea prevalence and food insecurity are significantly associated with wasting prevalence. Child care and displacement status were not. Aggregated analysis of small-scale surveys provides insights into the prevalence of wasting and factors explaining its variation. It can also guide survey planning towards areas with limited data availability. PMID:26828512

  4. Assessment of Vaccine Exemptions among Wyoming School Children, 2009 and 2011

    Science.gov (United States)

    Pride, Kerry R.; Geissler, Aimee L.; Kolasa, Maureen S.; Robinson, Byron; Van Houten, Clay; McClinton, Reginald; Bryan, Katie; Murphy, Tracy

    2014-01-01

    During 2010-2011, varicella vaccination was an added requirement for school entrance in Wyoming. Vaccination exemption rates were compared during the 2009-2010 and 2011-2012 school years, and impacts of implementing a new childhood vaccine requirement were evaluated. All public schools, grades K-12, were required to report vaccination status of…

  5. Diagnostic performance of a rapid in-clinic test for the detection of Canine Parvovirus under different storage conditions and vaccination status.

    Science.gov (United States)

    Kantere, Maria C; Athanasiou, Labrini V; Spyrou, Vassiliki; Kyriakis, Constantinos S; Kontos, Vassilios; Chatzopoulos, Dimitrios C; Tsokana, Constantina N; Billinis, Charalambos

    2015-04-01

    Canine parvovirus (CPV) is one of the most common causes of acute haemorrhagic enteritis in young dogs, while clinical diagnosis is often indecisive. The aim of our study was to evaluate the diagnostic accuracy of an in-clinic rapid test in the detection of CPV infection in dogs. To this end, we compared the Rapid Diagnostic Kit of Canine Parvovirus, Coronavirus and Rotavirus antigen (Quicking(®)) to PCR, which is considered as the most reliable diagnostic method. A total of 78 duplicated faecal samples were collected from diarrhoeic dogs. Vaccination history within a month prior to the onset of diarrhoea was reported for 12 of the sampled dogs. The rapid diagnostic test was performed in 23 of the faecal samples directly, while the rest were placed into a sterile cotton tipped swab suitable for collection and transportation of viruses (Sigma Σ-VCM(®)) and stored at -20 °C. The sensitivity of the Quicking rapid diagnostic test compared to PCR in the total number of samples, in samples from non-vaccinated dogs and in samples tested directly after collection were 22.22% (95% CI: 13.27-33.57%), 26.67% (95% CI: 16.08-39.66%) and 76.47% (95% CI: 50.10-93.04%) respectively, while the specificity of the test was 100% in any case. In conclusion, negative results do not exclude parvoenteritis from the differential diagnosis, especially in dogs with early vaccination history, but a positive result almost certainly indicates CPV infection. An improved sensitivity may be expected when the test is performed immediately.

  6. Diagnostic performance of a rapid in-clinic test for the detection of Canine Parvovirus under different storage conditions and vaccination status.

    Science.gov (United States)

    Kantere, Maria C; Athanasiou, Labrini V; Spyrou, Vassiliki; Kyriakis, Constantinos S; Kontos, Vassilios; Chatzopoulos, Dimitrios C; Tsokana, Constantina N; Billinis, Charalambos

    2015-04-01

    Canine parvovirus (CPV) is one of the most common causes of acute haemorrhagic enteritis in young dogs, while clinical diagnosis is often indecisive. The aim of our study was to evaluate the diagnostic accuracy of an in-clinic rapid test in the detection of CPV infection in dogs. To this end, we compared the Rapid Diagnostic Kit of Canine Parvovirus, Coronavirus and Rotavirus antigen (Quicking(®)) to PCR, which is considered as the most reliable diagnostic method. A total of 78 duplicated faecal samples were collected from diarrhoeic dogs. Vaccination history within a month prior to the onset of diarrhoea was reported for 12 of the sampled dogs. The rapid diagnostic test was performed in 23 of the faecal samples directly, while the rest were placed into a sterile cotton tipped swab suitable for collection and transportation of viruses (Sigma Σ-VCM(®)) and stored at -20 °C. The sensitivity of the Quicking rapid diagnostic test compared to PCR in the total number of samples, in samples from non-vaccinated dogs and in samples tested directly after collection were 22.22% (95% CI: 13.27-33.57%), 26.67% (95% CI: 16.08-39.66%) and 76.47% (95% CI: 50.10-93.04%) respectively, while the specificity of the test was 100% in any case. In conclusion, negative results do not exclude parvoenteritis from the differential diagnosis, especially in dogs with early vaccination history, but a positive result almost certainly indicates CPV infection. An improved sensitivity may be expected when the test is performed immediately. PMID:25707551

  7. Programa Bolsa Família e estado nutricional infantil: desafios estratégicos Bolsa Família Program and child nutritional status: strategic challenges

    Directory of Open Access Journals (Sweden)

    Fabiana de Cássia Carvalho Oliveira

    2011-07-01

    Full Text Available Anemia e desnutrição, principais carências nutricionais na infância, têm como principais determinantes os socioeconômicos. Assim, por se tratar da principal política de combate à pobreza, espera-se que o Programa Bolsa Família (PBF promova impacto no estado nutricional infantil. Objetivou-se analisar as diferenças na situação nutricional de crianças cadastradas no PBF de um município da Zona da Mata Mineira. Foram avaliadas 446 crianças com idade entre 6 e 84 meses, sendo que 262 eram beneficiárias e 184 não-beneficiárias. A avaliação nutricional constituiu-se da análise dos parâmetros peso e estatura, através dos índices peso/idade, peso/estatura, estatura/idade e Índice de Massa Corporal/idade, e dos níveis de hemoglobina, com uso do Hemocue. As prevalências de anemia, déficit estatural e obesidade foram 22,6, 6,3 e 5,2%, respectivamente, sendo que não houve diferença estatística entre os beneficiários e não-beneficiários. Inicialmente, o grupo beneficiário apresentava piores condições socioeconômicas, porém, com o recebimento do benefício, os grupos se igualaram financeiramente. É possível que a similaridade dos dois grupos também quanto ao estado nutricional possa ser atribuída ao recebimento do benefício, tanto devido ao incremento financeiro, quanto ao acompanhamento nutricional exigido como condicionalidade do programa.The main nutritional deficiencies during childhood, namely anemia and malnutrition, are predominantly related to socio-economic factors. Thus, as the Bolsa Família Program (BFP is the main policy to combat poverty, it is expected that it will have an impact on child nutrition. The aim was to analyze the differences in the nutritional situation of children registered with the BFP of a municipality located in Zona da Mata of Minas Gerais state. 446 children aged between 6 and 84 months were evaluated, of which 262 were non-beneficiaries and 184 were beneficiaries. Nutritional

  8. The evolution of poxvirus vaccines.

    Science.gov (United States)

    Sánchez-Sampedro, Lucas; Perdiguero, Beatriz; Mejías-Pérez, Ernesto; García-Arriaza, Juan; Di Pilato, Mauro; Esteban, Mariano

    2015-04-01

    After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, passaged in cattle and humans until the appearance of vaccinia virus (VACV), which was used in the final campaigns aimed to eradicate the disease, an endeavor that was accomplished by the World Health Organization (WHO) in 1980. Ever since, naturally evolved strains used for vaccination were introduced into research laboratories where VACV and other poxviruses with improved safety profiles were generated. Recombinant DNA technology along with the DNA genome features of this virus family allowed the generation of vaccines against heterologous diseases, and the specific insertion and deletion of poxvirus genes generated an even broader spectrum of modified viruses with new properties that increase their immunogenicity and safety profile as vaccine vectors. In this review, we highlight the evolution of poxvirus vaccines, from first generation to the current status, pointing out how different vaccines have emerged and approaches that are being followed up in the development of more rational vaccines against a wide range of diseases.

  9. The Evolution of Poxvirus Vaccines

    Directory of Open Access Journals (Sweden)

    Lucas Sánchez-Sampedro

    2015-04-01

    Full Text Available After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV, the causative agent of smallpox. Cowpox virus (CPXV and horsepox virus (HSPV were extensively used to this end, passaged in cattle and humans until the appearance of vaccinia virus (VACV, which was used in the final campaigns aimed to eradicate the disease, an endeavor that was accomplished by the World Health Organization (WHO in 1980. Ever since, naturally evolved strains used for vaccination were introduced into research laboratories where VACV and other poxviruses with improved safety profiles were generated. Recombinant DNA technology along with the DNA genome features of this virus family allowed the generation of vaccines against heterologous diseases, and the specific insertion and deletion of poxvirus genes generated an even broader spectrum of modified viruses with new properties that increase their immunogenicity and safety profile as vaccine vectors. In this review, we highlight the evolution of poxvirus vaccines, from first generation to the current status, pointing out how different vaccines have emerged and approaches that are being followed up in the development of more rational vaccines against a wide range of diseases.

  10. Tumor vaccines

    International Nuclear Information System (INIS)

    Tumor vaccines have several potential advantages over standard anticancer regiments. They represent highly specific anticancer therapy. Inducing tumor-specific memory T-lymphocytes, they have potential for long-lived antitumor effects. However, clinical trials, in which cancer patients were vaccinated with tumor vaccines, have been so far mainly disappointing. There are many reasons for the inefficiency of tumor vaccines. Most cancer antigens are normal self-molecules to which immune tolerance exists. That is why the population of tumor-specific lymphocytes is represented by a small number of low-affinity T-lymphocytes that induce weak antitumor immune response. Simultaneously, tumors evolve many mechanisms to actively evade immune system, what makes them poorly immunogenic or even tolerogenic. Novel immunotherapeutic strategies are directed toward breaking immune tolerance to tumor antigens, enhancing immunogenicity of tumor vaccines and overcoming mechanisms of tumor escape. There are several approaches, unfortunately, all of them still far away from an ideal tumor vaccine that would reject a tumor. Difficulties in the activation of antitumor immune response by tumor vaccines have led to the development of alternative immunotherapeutic strategies that directly focus on effector mechanisms of immune system (adoptive tumor- specific T-lymphocyte transfer and tumor specific monoclonal antibodies). (author)

  11. A study to assess and measure the breaches in the child rights

    Directory of Open Access Journals (Sweden)

    Pooja Chaudhary

    2014-10-01

    Full Text Available Background: Children signify eternal optimism in the human being and provide potential for the development. Every nation whether developed or developing, links its future with the status of child. An understanding of the physical, social and behavioral factors is conducive to assess the current situation and vulnerability of any child. To ensure the utmost level of health and safety of a child, we need to have an insight of the violation of child rights. We conducted this study to assess and measure the breaches in child rights. Materials and Methods: A cross-sectional study was carried out among 200 children between 10 to 18 years of age in one of the field practice areas of Community Medicine department, B. J. Medical College, Ahmedabad. Results: More than 90% of the children were born in the hospital settings, fully vaccinated and living with their parents. Of these, 60% of the children reported to have some kind of illness in the past one year, and majority of them approached healthcare facility for that the treatment. Of these, 26% of them had low birth weight (LBW and 68% had body mass index (BMI <18.5. About 93% of the children were enrolled in either government or private school and out of them, 54% complained of the burden of either homework or tuition. Of these, 6.5% children were school dropouts and all of them were girls; 4% of them were child labors. Conclusion: The study indicated positive findings in the areas of child survival, development and to some extent, in the domain of right to participation, though there were poor environmental conditions and recreational activities. Prevalence of malnutrition and child labor was also high. Study results highlighted the need for adequate services in these areas.

  12. The status survey of only child loss families and only child disabled families in Renhe district of Panzhihua city%四川攀枝花市仁和区失独及独生子女伤残家庭现状调查分析

    Institute of Scientific and Technical Information of China (English)

    李天蓉

    2015-01-01

    Objective To explore the status of only child loss families and only child disabled families in Renhe district of Panzhihua city,to provide the basis for government policy making. Methods A total of 174 only child loss families and only child disabled families were surveyed,the reasons of child loss,conditions of disability,influence factors of reproduction and endowment situation were analyzed. Results Among 174 only child loss families,the main reasons of child loss included illness,contingency, traffic accident which accounted for 87 % . The conditions of disability mainly were physical disability,cerebral diseases and hearing disability which accounted for 74 % . The psychical factors were the dominating influence factors of reproduction in only child loss families,while the economic factors were the dominating influence factors of reproduction in only child disabled family. For endowment situation,the institutional pension accounted for 53 % ,while family pension accounted for 47 % . Conclusion The only child loss families and only child disabled families are facing the problems of psychological trauma,economic distress,reproduction difficulties, endowment,medical security,et al,which need the corresponding social insurance and care.%目的:了解攀枝花市仁和区失独及独生子女伤残家庭基本情况,为政府制定政策提供依据。方法对攀枝花市仁和区174个失独及独生子女伤残家庭开展调查,分析失独原因和伤残状况,影响再生育因素及养老状况。结果调查174户独生子女家庭,失独原因中疾病、意外事故、交通事故,占失独总数的87%。伤残现状中肢体残疾、脑部疾病,听力残疾,占伤残总数的74%。影响再生育因素:失独家庭中心理精神因素居首位,伤残中经济因素居首位。养老现状:60岁以上,机构养老占53%,家庭养老占47%。结论失独和伤残家庭面临精神创伤和经济窘迫、再生育困难

  13. HPV vaccination's second act: promotion, competition, and compulsion.

    Science.gov (United States)

    Schwartz, Jason L

    2010-10-01

    Developments regarding human papillomavirus (HPV) vaccines will transform HPV vaccination in the United States while simultaneously raising several new policy and ethical concerns. Policymakers, vaccine manufacturers, and the public health community must now respond to the presence of competing vaccines that are similar but distinct, particularly with respect to genital wart prevention and the benefits of vaccinating males. This work arises in the shadow of the contentious introduction of the HPV vaccine Gardasil (Merck & Co, Inc, Whitehouse Station, NJ) in 2006, particularly the opposition to efforts in many states to require the vaccine for school attendance. I review the current status of HPV vaccine policy in the United States and examine issues of public health ethics and policy central to ongoing and future HPV vaccination programs.

  14. Meningococcal Vaccinations.

    Science.gov (United States)

    Crum-Cianflone, Nancy; Sullivan, Eva

    2016-06-01

    Neisseria meningitidis, a gram-negative diplococcal bacterium, is a common asymptomatic nasopharyngeal colonizer that may infrequently lead to invasive disease in the form of meningitis or bacteremia. Six serogroups (A, B, C, W, X and Y) are responsible for the majority of invasive infections. Increased risk of disease occurs in specific population groups including infants, adolescents, those with asplenia or complement deficiencies, and those residing in crowded living conditions such as in college dormitories. The incidence of invasive meningococcal disease varies geographically with some countries (e.g., in the African meningitis belt) having both high endemic disease rates and ongoing epidemics, with annual rates reaching 1000 cases per 100,000 persons. Given the significant morbidity and mortality associated with meningococcal disease, it remains a major global health threat best prevented by vaccination. Several countries have implemented vaccination programs with the selection of specific vaccine(s) based on locally prevalent serogroup(s) of N. meningitidis and targeting population groups at highest risk. Polysaccharide meningococcal vaccines became available over 40 years ago, but are limited by their inability to produce immunologic memory responses, poor immunogenicity in infants/children, hyporesponsiveness after repeated doses, and lack of efficacy against nasopharyngeal carriage. In 1999, the first meningococcal conjugate vaccines were introduced and have been successful in overcoming many of the shortcomings of polysaccharide vaccines. The implementation of meningococcal conjugate vaccination programs in many areas of the world (including the massive campaign in sub-Saharan Africa using a serogroup A conjugate vaccine) has led to dramatic reductions in the incidence of meningococcal disease by both individual and population protection. Progressive advances in vaccinology have led to the recent licensure of two effective vaccines against serogroup B

  15. Preparing Your Child for a New Sibling (For Parents)

    Science.gov (United States)

    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which ... about an older child feeling left out. Take advantage of chances for one-on-one time with ...

  16. Childcare immunization programme – to what extent are children covered by vaccinations in Greenland?

    OpenAIRE

    Bjarnason Skifte, Turid

    2004-01-01

    Objectives: New vaccines in the child healthcare programme are regularly considered. When considering the introduction of the Hepatitis-B vaccine into the programme, it was asked to what extent children in Greenland were actually covered by the existing immunization series. Would introducing new vaccines make any sense if the percentage of children immunized was shown to be low? A telephone enquiry conducted in 2000 showed a tendency of very high percentage of full coverage per child (98-99 %...

  17. Countermeasures to Improve Outpatient Vaccination Prevention Status and Satisfaction%预防接种门诊现状及其满意度提升对策

    Institute of Scientific and Technical Information of China (English)

    肖小燕

    2014-01-01

    本文介绍青原区疾控预防接种门诊规范化建设现状,分析预防接种门诊工作中的好和差两方面情况,好的方面是制度较为健全、接种环境改善,差的方面是工作积极性不高、有差错操作。防接种门诊工作满意度提升专项工作中,强化制度、规范的辅助性工作,提出了切近实际的多项措施,取得接种率提高到90%以上、差错率明显降低和满意度评议中达到80%等良好成绩。%This article introduced QingYuan district CDC vaccination outpatient service standardization construction situation, analysis of vaccination outpatient service work in both good and bad, good is system more perfect, the inoculation environment improvement, is of poor work enthusiasm is not high, proposed the present practical measures, obtain coverage to 90%above, significantly lower er or rate and satisfaction evaluation, such as 80%of good results.

  18. Consensus document on the approach to children with allergic reactions after vaccination or allergy to vaccine components.

    Science.gov (United States)

    Echeverría-Zudaire, Luis A; Ortigosa-del Castillo, Luis; Alonso-Lebrero, Elena; Álvarez-García, Francisco J; Cortés-Álvarez, Nuria; García-Sánchez, Nuria; Martorell-Aragonés, Antonio

    2015-01-01

    Vaccinations are one of the main public health tools for the control of vaccine-preventable diseases. If a child is identified as having had an allergic reaction to a vaccine, subsequent immunisations will probably be suspended - with the risks such a decision implies. The incidence of severe allergic reactions is very low, ranging between 0.5 and 1 cases/100,000 doses. Rather than the vaccine antigens as such, the causes of allergic reactions to vaccines are often residual protein components of the manufacturing process such as gelatine or egg, and less commonly yeasts or latex. Most vaccine reactions are mild and circumscribed to the injection site; although in some cases severe anaphylactic reactions can be observed. If an immediate-type allergic reaction is suspected at vaccination, or if a child with allergy to some of the vaccine components is scheduled for vaccination, a correct diagnosis of the possible allergic process must be made. The usual vaccine components must be known in order to determine whether vaccination can be safely performed.

  19. Measles incidence, vaccine efficacy, and mortality in two urban African areas with high vaccination coverage

    DEFF Research Database (Denmark)

    Aaby, Peter; Knudsen, K; Jensen, T G;

    1990-01-01

    Measles incidence, vaccine efficacy, and mortality were examined prospectively in two districts in Bissau where vaccine coverage for children aged 12-23 months was 81% (Bandim 1) and 61% (Bandim 2). There was little difference in cumulative measles incidence before 9 months of age (6.1% and 7.......6%, respectively). Between 9 months and 2 years of age, however, 6.1% contracted measles in Bandim 1 and 13.7% in Bandim 2. Even adjusting for vaccination status, incidence was significantly higher in Bandim 2 (relative risk 1.6, P = .04). Even though 95% of the children had measles antibodies after vaccination......, vaccine efficacy was not more than 68% (95% confidence interval [CI] 39%-84%) and was unrelated to age at vaccination. Unvaccinated children had a mortality hazard ratio of 3.0 compared with vaccinated children (P = .002), indicating a protective efficacy against death of 66% (CI 32%-83%) of measles...

  20. Challenges and Opportunities in Early Childhood: Views of the CEOs of the Big Three--Twenty-First Annual Status Report on For Profit Child Care

    Science.gov (United States)

    Neugebauer, Roger

    2008-01-01

    This article presents the viewpoints of the CEOs of the three largest for profit child care organizations in North America about trends in their field. The three individuals are: (1) David Lissy, CEO, Bright Horizons Family Solutions; (2) Felicia Thornton, CEO, Knowledge Universe Education, U.S. (parent company for Knowledge Learning Corporation);…

  1. Tetanus trismus in a 2 year old child: Case report

    Directory of Open Access Journals (Sweden)

    Menon Narayanankutty Sunilkumar, Vadakut Krishnan Parvathy

    2014-07-01

    Full Text Available Tetanus is still a major cause of mortality and morbidity in developing countries. It occurs in children mainly in the unimmunized, due to parental ignorance and objection to vaccination. This potentially fatal disease caused by a neurotoxin, tetanospasmin released from wounds infected with Clostridium tetani, an anaerobic gram–positive bacillus. As tetanus becomes less common, cases are likely to be misdiagnosed or go unrecognized. In this case report, we present a case of tetanus in a partially immunized 2 year old girl who presented with trismus. She was treated with the recent recommendations and adequate supportive care. Detection of tetanus at a very early stage can favor lifesaving interventions. Trismus, infected wound and partially immunized/unimmunized status of a child were the key features leading to the prompt diagnosis and early treatment.

  2. Vaccination coverage of patients with inborn errors of metabolism and the attitudes of their parents towards vaccines.

    Science.gov (United States)

    Cerutti, Marta; De Lonlay, Pascale; Menni, Francesca; Parini, Rossella; Principi, Nicola; Esposito, Susanna

    2015-11-27

    To evaluate vaccination coverage of children and adolescents with inborn errors of metabolism (IEMs) and the attitudes of their parents towards vaccination, the vaccination status of 128 patients with IEM and 128 age- and gender-matched healthy controls was established by consulting the official vaccination chart. In children with IEMs, compared with healthy controls, low vaccination rates and/or delays in administration were observed for pneumococcal conjugate, meningococcus C, measles, mumps, rubella, diphtheria-tetanus-pertussis-inactivated polio, Bacillus Calmette-Guerin, and influenza vaccines. Among the parents of IEM patients, vaccine schedule compliance was primarily driven by the doctors at the hospital's reference centres; among the parents of the healthy controls, compliance was driven by the primary care paediatricians. These results show that IEM patients demonstrate sub-optimal vaccination coverage. Further studies of the different vaccines in each IEM disorder and educational programmes aimed at physicians and parents to increase immunization coverage in these patients are urgently needed.

  3. Vaccination against bacterial kidney disease: Chapter 22

    Science.gov (United States)

    Elliott, Diane G.; Wiens, Gregory D.; Hammell, K. Larry; Rhodes, Linda D.; Edited by Gudding, Roar; Lillehaug, Atle; Evensen, Øystein

    2014-01-01

    Bacterial kidney disease (BKD) of salmonid fishes, caused by Renibacterium salmoninarum, has been recognized as a serious disease in salmonid fishes since the 1930s. This chapter discusses the occurrence and significance, etiology, and pathogenesis of BKD. It then describes the different vaccination procedures and the effects and side-effects of vaccination. Despite years of research, however, only a single vaccine has been licensed for prevention of BKD, and has demonstrated variable efficacy. Therefore, in addition to a presentation of the current status of BKD vaccination, a discussion of potential future directions for BKD vaccine development is included in the chapter. This discussion is focused on the unique characteristics of R. salmoninarum and its biology, as well as aspects of the salmonid immune system that might be explored specifically to develop more effective vaccines for BKD prevention.

  4. HPV vaccine

    Science.gov (United States)

    ... EFFECTS The most common side effects are fainting, dizziness, nausea, headache, and skin reactions at the site where the shot was given. WHAT ELSE TO THINK ABOUT The HPV vaccine does not protect against all types of HPV ...

  5. Arthropod vaccines.

    Science.gov (United States)

    Lee, R; Opdebeeck, J P

    1999-03-01

    Antigens located in the midgut of the tick are hidden from the host's immune system. Egg production of ticks can be reduced when ticks are fed on animals vaccinated with midgut antigens of the tick, and a subunit vaccine formulated with the recombinant antigen Bm86 is now available that can reduce the number of ticks infesting cattle grazing on pasture. Midgut antigens used in vaccines against insects that transmit pathogenic organisms to humans have not been as effective in reducing insect fecundity and an alternative approach may be necessary. Transmission-blocking vaccines directed at interfering with the vector-pathogen interaction could result in loss of vector competence and block the spread of disease-causing organisms. PMID:10198800

  6. Rotavirus vaccines: viral shedding and risk of transmission.

    Science.gov (United States)

    Anderson, Evan J

    2008-10-01

    Rotavirus causes gastroenteritis in almost all children by 5 years of age. Immunity to rotavirus is incomplete, with potential for recurrent infections occurring throughout life. Live rotavirus vaccines have been developed for the protection of children from severe wildtype rotavirus infections. Transmission of vaccine virus strains from vaccinated children to unvaccinated contacts harbours the potential for herd immunity, but also the risk of vaccine-derived disease in immunocompromised contacts. A review of rotavirus vaccine prelicensure studies shows that viral shedding and transmission were higher with the old tetravalent rhesus rotavirus vaccine than with the current human attenuated monovalent rotavirus vaccine and the pentavalent bovine-human reassortant vaccine. Immunocompromised contacts should be advised to avoid contact with stool from the immunised child if possible, particularly after the first vaccine dose for at least 14 days. Since the risk of vaccine transmission and subsequent vaccine-derived disease with the current vaccines is much less than the risk of wildtype rotavirus disease in immunocompromised contacts, vaccination should be encouraged.

  7. 农村育龄妇女孕前保健服务认知现状及其影响因素的调查研究%Awareness Status of Preconception Health Care among Rural Women of Child-Bearing Age and Its Determinants

    Institute of Scientific and Technical Information of China (English)

    杜敏霞; 张海洋; 张昌强; 姚桂英; 张楠; 张珍珍

    2011-01-01

    目的 了解农村育龄妇女对孕前保健服务的认知状况及其影响因素,为制定孕前保健服务推广策略提供科学依据.方法 采用分层抽样方法选取1 226名农村育龄期妇女为调查对象,采用自制调查问卷进行入户调查获取孕前保健服务认知资料.结果 农村育龄妇女对孕前保健服务内容、服务获取途径的知晓率分别为54.6%~69.3%、14.0%;对母婴传播疾病监测、孕前妇科检查、TORCH感染监测、注射风疹疫苗、染色体检查、补充叶酸、血型检查等服务项目意义的知晓率依次为37.4%、25.9%、21.7%、0.4%、25.1%、55.7%和32.2%.多因素Logistic回归分析显示,文化程度、年龄、服务了解途径(计划生育宣传员、专科医生、宣传资料)对农村育龄妇女孕前保健服务认知水平的影响有统计学意义(P<0.05).结论 农村育龄妇女对孕前保健服务的认知水平普遍偏低,文化水平、年龄、相关知识获取途径是影响育龄妇女孕前保健服务认知水平的重要因素;应结合农村实际情况有针对性地开展孕前保健服务宣传,切实促进服务的有效利用.%Objective To know the status of awareness about preconception health care among rural women of child -bearing age and analyze its determinants so as to provide the scientific basis for formulating the popularizing strategy of preconception health care service. Methods Stratified sampling was taken to recruit 1 226 rural women of child - bearing age as the subjects , and self - designed questionnaire was used to collect the information on their knowledge of preconception health care. Results The awareness rates of the contents of preconception health service and the approach to get the service were 54. 6% ~ 69. 3% and 14. 0% among the women of child - bearing age. The awareness rates of significance such items as monitoring of mother to infant transmission diseases, gynecological pre - pregnant examination, TORCH

  8. Study on depression status of only-child and non-only-child middle school students in Hefei: a cross-sectional study%合肥市中学生独生与非独生子女的抑郁状况调查

    Institute of Scientific and Technical Information of China (English)

    章清荷; 董永海; 张志华; 郑睿智; 刘娟娟; 董青; 张茜; 黄芬

    2013-01-01

    Objective To realize the current situation and influencing factors on the depression status of only-child students in the middle school in Hefei City. Methods Stratified cluster sampling was used to select 2 964 only-child students from 3 urban middle schools of Hefei City. These students were surveyed by self-rating depression scale ( SDS) , UCLA loneliness scale, the self-esteem scale (SES) , simplified coping style questionnaire (SCSQ) as well as demographic information. Results Total rate of depression was 39. 51 % among middle school students and the rate of depression in only-child students (37. 14% ) was lower than those in non-only-child students (42. 01% ). Only-child students' depression scores (47. 11 ±8. 14) was lower than that of non-only students (47. 75 ±8. 48) , and both of them were higher than that of Chinese norm(41. 88 ± 10. 57). Multiple factors analysis revealed that loneliness, self-esteem and subjective well-being were main factors for only-child and non-only-child students. Moreover, non-only-child boys' emotion of depression was related to parents' divorce. Study pressure had a great impact on depression among only-child students, especially among only-child girls. Conclusions Emotion of depression is widespread among middle school students, so we should take pertinent measures to develop psychological healthy education associated with school, family and society.%目的 了解合肥市城区独生子女与非独生子女的抑郁状况及其影响因素,为独生子女的心理健康教育提供依据.方法 运用分层整群抽样方法,采用抑郁自评量表(self-rating depression scale,SDS),UCLA孤独量表、自尊量表(the self-esteem scale,SES)和简易应对方式问卷(simplified coping style questionnaire,SCSQ),对合肥市3所中学共2 964名学生进行问卷调查.结果 本次调查自评抑郁检出率为39.51%,其中独生子女抑郁检出率(37.14%)低于非独生子女(42.01%)

  9. Antipneumococcal vaccination

    Directory of Open Access Journals (Sweden)

    Gian Vincenzo Zuccotti

    2013-06-01

    Full Text Available Streptococcus pneumoniae (SP is a gram-positive bacterium with more than 90 known serotypes causing around 11% of all deaths worldwide in children aged 1-59 months. A new era in prevention of SP-related diseases started in at the beginning of 2000s when a 7-valent pneumococcal conjugate vaccine (PCV7 was recommended as the vaccine of choice in pediatric age. PCV7 dramatically reduced invasive pneumococcal diseases (IPD among children with indirect effects noted among other age groups as well. However, thanks to a strict surveillance network, an increase in non-vaccine serotypes (NVTs causing IPD was noted worldwide and in late 2000s a new second generation vaccine (13-valent pneumococcal conjugate vaccine-PCV13 with an expanded serotype coverage was licensed. Due to the lack of solid effectiveness data, up to know it is difficult to predict how the composition of NVTs will change after the large-scale introduction of PCV13 or whether the characteristics of the serotypes will change. Long-term surveillance of both IPD, pneumonia, acute otitis media and carriage will be crucial to ascertain whether these second generation vaccines are having the desired effect of reducing the incidence of diseases in the long term. Proceedings of the 9th International Workshop on Neonatology · Cagliari (Italy · October 23rd-26th, 2013 · Learned lessons, changing practice and cutting-edge research

  10. Ear Infection and Vaccines

    Science.gov (United States)

    ... an ENT Doctor Near You Ear Infection and Vaccines Ear Infection and Vaccines Patient Health Information News ... or may need reinsertion over time. What about vaccines? A vaccine is a preparation administered to stimulate ...

  11. Vaccines and Thimerosal

    Science.gov (United States)

    ... Preparedness Vaccine Safety Partners About ISO Thimerosal in Vaccines Recommend on Facebook Tweet Share Compartir Thimerosal is ... harm. Thimerosal prevents the growth of bacteria in vaccines. Thimerosal is added to vials of vaccine that ...

  12. Live Virus Smallpox Vaccine

    Science.gov (United States)

    ... A - Z Index SMALLPOX FACT SHEET The Live Virus Smallpox Vaccine The vaccinia virus is the "live ... it cannot cause smallpox. What is a "live virus" vaccine? A "live virus" vaccine is a vaccine ...

  13. Role of word-of-mouth for programs of voluntary vaccination: A game-theoretic approach.

    Science.gov (United States)

    Bhattacharyya, Samit; Bauch, Chris T; Breban, Romulus

    2015-11-01

    We propose a model describing the synergetic feedback between word-of-mouth (WoM) and epidemic dynamics controlled by voluntary vaccination. The key feature consists in combining a game-theoretic model for the spread of WoM and a compartmental model describing VSIR disease dynamics in the presence of a program of voluntary vaccination. We evaluate and compare two scenarios for determinants of behavior, depending on what WoM disseminates: (1) vaccine advertising, which may occur whether or not an epidemic is ongoing and (2) epidemic status, notably disease prevalence. Understanding the synergy between the two strategies could be particularly important for designing voluntary vaccination campaigns. We find that, in the initial phase of an epidemic, vaccination uptake is determined more by vaccine advertising than the epidemic status. As the epidemic progresses, epidemic status becomes increasingly important for vaccination uptake, considerably accelerating vaccination uptake toward a stable vaccination coverage.

  14. Role of word-of-mouth for programs of voluntary vaccination: A game-theoretic approach.

    Science.gov (United States)

    Bhattacharyya, Samit; Bauch, Chris T; Breban, Romulus

    2015-11-01

    We propose a model describing the synergetic feedback between word-of-mouth (WoM) and epidemic dynamics controlled by voluntary vaccination. The key feature consists in combining a game-theoretic model for the spread of WoM and a compartmental model describing VSIR disease dynamics in the presence of a program of voluntary vaccination. We evaluate and compare two scenarios for determinants of behavior, depending on what WoM disseminates: (1) vaccine advertising, which may occur whether or not an epidemic is ongoing and (2) epidemic status, notably disease prevalence. Understanding the synergy between the two strategies could be particularly important for designing voluntary vaccination campaigns. We find that, in the initial phase of an epidemic, vaccination uptake is determined more by vaccine advertising than the epidemic status. As the epidemic progresses, epidemic status becomes increasingly important for vaccination uptake, considerably accelerating vaccination uptake toward a stable vaccination coverage. PMID:26367185

  15. 肠道病毒71型灭活疫苗相关研究现状%Current status of research of inactivated enterovirus 71 vaccines

    Institute of Scientific and Technical Information of China (English)

    杨二霞

    2013-01-01

    Hand-foot-and-mouth disease (HFMD) is a life-threatening infectious disease of children under 5 years old.In recent years,major outbreaks of HFMD caused by enterovirus 71 (EV71) have emerged in the Asia-Pacific region,and have resulted in millions of cases and hundreds of deaths each year in China since 2008.Because EV71 is one of the main pathogens of HFMD resulting in severe diseases and death,the pathogenesis of HFMD is still unclear,and no effective therapeutic drugs for EV71 infection are currently available,development of vaccines against EV71 is urgently needed.This review summarizes research progress of inactivated EV71 vaccines.%手足口病是一种威胁5岁以下儿童生命健康的传染病,近年来已在亚太地区造成了多次上百万患者发病的大规模暴发,仅在中国大陆,自2008年以来,每年发病人数就超过百万,死亡数百人.然而,由于肠道病毒71型(enterovirus 71,EV71)是导致重症和死亡病例的主要病原体,而其致病机制尚不清楚,目前尚无有效的治疗性药物,因此EV71疫苗研究成为迫切需要解决的问题.此文就EV71灭活疫苗研究进展进行综述.

  16. Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination

    DEFF Research Database (Denmark)

    Timmermann, Clara Amalie Gade; Osuna, Christa Elyse; Steuerwald, Ulrike;

    2015-01-01

    -specific IgE was quantified in the child's serum, and at age 13, the children underwent skin prick tests (SPT). The child's vaccination card was reviewed at examinations. RESULTS: At age 5, 533 of 555 children had been vaccinated for MMR. After confounder adjustment we found early life MMR vaccination.......8% (CI 95%: -84.3%; -11.9%) in the vaccinated children. MMR vaccination was not significantly associated with allergic rhinoconjuctivitis symptoms, eczema, or SPT reactions at age 13. CONCLUSIONS: MMR vaccination early in life may have a protective effect against allergy at least up to age 7 and against......BACKGROUND: The existing literature on the association between measles vaccination and subsequent risk of allergic disease is inconclusive. The aim of this study was, therefore, to determine whether measles, mumps and rubella (MMR) vaccination administered in early childhood was associated...

  17. Erysipelothrix rhusiopathiae and Mycoplasma hyopneumoniae: the sensitivities of enzyme-linked immunosorbent assays for detecting vaccinated sows of unknown disease status using serum and colostrum, and the correlation of the results for sow serum, colostrum, and piglet serum.

    Science.gov (United States)

    Jenvey, Caitlin J; Reichel, Michael P; Cockcroft, Peter D

    2015-03-01

    Due to relatively high concentrations of immunoglobulins, colostrum has the potential to improve the sensitivity of diagnostic tests for diseases in pigs when compared with serum. It is possible that colostrum could improve the sensitivity of the antibody enzyme-linked immunosorbent assay (ELISA) compared with serum. Colostrum is also essential for piglets, providing protection against infections in the first few weeks and months of life. The sensitivity of 2 commercially available ELISAs, one for the detection of Erysipelothrix rhusiopathiae and the second for Mycoplasma hyopneumoniae antibodies, when used with sow colostrum in comparison with serum was investigated. The correlation of maternal E. rhusiopathiae- and M. hyopneumoniae-specific antibody levels with specific-antibody serum levels in the piglet was also determined. The sensitivity was defined as the proportion of vaccinated sows that were correctly identified as vaccinated at a given cutoff point. The true disease status of the sows with regard to the 2 infections was unknown. Blood and colostrum samples were collected from 20 sows, 10 primiparous and 10 multiparous, and blood samples were also collected from the piglets of each sow, 48-72 hr post-farrowing. The sensitivities of both ELISAs were significantly improved when using colostrum compared with serum. Sow serum and colostrum optical density (OD) values were significantly correlated. The mean sow OD values for serum for E. rhusiopathiae and M. hyopneumoniae and colostrum for E. rhusiopathiae were significantly correlated with piglet serum OD levels. If the improved sensitivity of colostrum can be demonstrated in infected animals, this will increase the ability of the test to identify infected animals using both individual and pooled colostrum. Testing serum and/or colostrum using ELISA can be useful predictors of piglet disease-specific OD values.

  18. 失独家庭父母身心健康状况与生活质量的对照研究%Investigation of the physical and psychological status and life quality in losing-only-child-families

    Institute of Scientific and Technical Information of China (English)

    郑志坚; 张伟东; 马娟; 刘健; 张俊宝; 马增斌; 樊庆洲; 陈诚; 孟凡强

    2015-01-01

    Objective To study the physical and psychological status and life qualities in losing only-child families in the country,city and metropolis to provide clues for formulating corresponding policies in China.Methods The survey of 405 losing-only-child families was conducted in Beijing (metropolis),Anhui province Hefei city and Shandong province Juye county (town).The physical and psychological health status of parents in these families was analyzed by questionnaire.The measurements of depression and anxiety were performed by self-rating depression scale (SDS) and self-rating anxiety scale (SAS).The qualities of their life were evaluated by social support rate scale and quality of life scale SF36.The data was processed by analysis of variance test.Results The scores of SDS in Beijing,Hefei city and Juye country were 39.3,42.9,53.0 in the fathers and 41.8,43.0,59.3 in the mothers,respectively.The scores of SAS in Beijing,Hefei city and Juye country were 31.38,31.19,44.67 in the fathers and 34.2,33.8,49.6 in the mothers,respectively.The scores of physical function in Beijing,Hefei city and Juye country were 52.8,51.6,46.5 in the fathers and 52.49,50.4,45.6 in the mothers,respectively.The scores of mental function in Beijing,Hefei city and Juye country were 52.8,51.6 and 46.7 in the fathers and 45.0,50.0,31.0 in the mothers,respectively (all P<0.05).The SAS score of losing-only-child-parents with grandchildren was 34.6 in the fathers,and 38.3 in the mothers (P<0.05).The SAS score of losing-only-child parents with grandchildren was 31.5 in the fathers,and 34.33 in the mothers (P<0.05).Conclusions Both the physical and psychological status of losing-only-child families are poor,and their qualities of life are decreased significantly.There are significant differences in physical and psychological status and qualities of life between the families in the different regions.The degree of depression and anxiety in losing-only-child-parents is decreasing after 20 years of

  19. 西安市2011年妇幼保健机构卫生人力资源现状分析%Current status analysis on human resources in maternal and child health institutions in Xi'an in 2011

    Institute of Scientific and Technical Information of China (English)

    曹朝侠; 郑兴荣; 刘菊玲

    2013-01-01

    目的了解西安市妇幼卫生人力资源发展现状及存在的主要问题,为合理配置妇幼卫生人力资源提供依据。方法对西安市妇幼保健机构资源与运营情况调查表中获得的数据进行描述性分析。结果西安市妇幼保健机构县、区、市均存在妇%Objective To understand the current status and main problems of human resources in maternal and child health institutions in Xi'an for providing reasonable basis for human resource allocation .Methods A descriptive analysis was conducted on the data obtained from questionnaires on institutional resources and operating in Xi'an maternal and child health institutions .Results A common problem was found in deficient allocation of maternal and child health personnel in institutions of county , district and city .The ratio of physicians and nurses was imbalance , and it was 1∶2.73, 1∶1.35, and 1∶0.91 in county, district and city respectively .Educational degree of the staff was low, and the professional title structure was unreasonable .The ratio of senior/junior/primary title was 1∶5.43∶20.21, 1∶6.25∶15.67 and 1∶1.58∶2.65 in county institutions, district institutions and city institutions , respectively.The ratio of senior personnel was only 0.57.The differences among different institutions were great , and the investment of continuing education was insufficient .Conclusion It is needed to increase investment , formulate relevant policy and set up the long-term mechanism of maternal and child health human resources developm-ent.Training should be strengthened and the quality of technical personnel should be improved by multi -channel and multi-form.Meanwhile, resources should be integrated and the existing maternal and child health human resources must be allocated reasonably and fully used .

  20. Parents' Perception and their Decision on their Children's Vaccination Against Seasonal Influenza in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    Lei He; Qiu-Yan Liao; You-Qi Huang; Shuo Feng; Xiao-Ming Zhuang

    2015-01-01

    Background:Seasonal influenza epidemic occurs every year in Guangzhou,which can affect all age groups.Young children are the most susceptible targets.Parents can decide whether to vaccinate their children or not based on their own consideration in China.The aim of this study was to identify factors that are important for parental decisions on vaccinating their children against seasonal influenza based on a modified health belief model (HBM).Methods:A cross-sectional study was conducted in Guangzhou,China.A total of 335 parents who had at least on child aged between 6 months and 3 years were recruited from women and children's hospital in Guangzhou,China.Each eligible subject was invited for a face-to-face interview based on a standardized questionnaire.Results:Uptake of seasonal influenza within the preceding 12 months among the target children who aged between 6 months and 36 months was 47.7%.Around 62.4% parents indicated as being "likely/very likely" to take their children for seasonal influenza vaccination in the next 12 months.The hierarchical logistic regression model showed that children's age (odds ratio [OR] =2.59,95% confidence interval [CI]:1.44-4.68),social norm (OR =2.08,95% CI:1.06-4.06) and perceived control (OR =2.96,95% CI:1.60-5.50) were significantly and positively associated with children's vaccination uptake within the preceding 12 months; children with a history of taking seasonal influenza vaccine (OR =2.50,95% CI:1.31-4.76),perceived children's health status (OR =3.36,95% CI:1.68-6.74),worry/anxious about their children influenza infection (OR =2.31,95% CI:1.19-4.48) and perceived control (OR =3.21,95% CI:1.65-6.22) were positively association with parental intention to vaccinate their children in the future 12 months.However,anticipated more regret about taking children for the vaccination was associated with less likely to vaccinate children within the preceding 12 months (OR =0.21,95% CI:0.08-0.52).Conclusions

  1. Review of randomized controlled trials on psychological interventions in child sexual abuse: Current status and emerging needs in the Indian context

    Directory of Open Access Journals (Sweden)

    Vandana Choudhary

    2016-01-01

    Full Text Available Child sexual abuse (CSA is a critical, psychologically traumatic and sometimes life-threatening incident often associated with sequel of adverse physical, behavioral, and mental health consequences. Factors such as developmental age of the child, severity of abuse, closeness to the perpetrator, availability of medico-legal-social support network and family care, gender stereotypes in the community complicate the psychological trauma. Although the research on the effects of CSA as well as psychological intervention to reduce the victimization and promote the mental health of the child is in its infancy stage in India, the global research in the past three decades has progressed much ahead. A search was performed using MEDLINE, PubMed, PsycINFO, and Google Scholar from 1984 to 2015 and only 17 randomized controlled trials (RCTs out of 96 potentially relevant studies were included. While nonspecific therapies covering a wide variety of outcome variables were prominent till 1999s, the trend changed to specific and focused forms of trauma-focused therapies in next one-and-half decades. Novel approaches to psychological interventions have also been witnessed. One intervention (non-RCT study on effects on general counseling has been reported from India.

  2. Review of Randomized Controlled Trials on Psychological Interventions in Child Sexual Abuse: Current Status and Emerging Needs in the Indian Context.

    Science.gov (United States)

    Choudhary, Vandana; Satapathy, Sujata; Sagar, Rajesh

    2016-01-01

    Child sexual abuse (CSA) is a critical, psychologically traumatic and sometimes life-threatening incident often associated with sequel of adverse physical, behavioral, and mental health consequences. Factors such as developmental age of the child, severity of abuse, closeness to the perpetrator, availability of medico-legal-social support network and family care, gender stereotypes in the community complicate the psychological trauma. Although the research on the effects of CSA as well as psychological intervention to reduce the victimization and promote the mental health of the child is in its infancy stage in India, the global research in the past three decades has progressed much ahead. A search was performed using MEDLINE, PubMed, PsycINFO, and Google Scholar from 1984 to 2015 and only 17 randomized controlled trials (RCTs) out of 96 potentially relevant studies were included. While nonspecific therapies covering a wide variety of outcome variables were prominent till 1999s, the trend changed to specific and focused forms of trauma-focused therapies in next one-and-half decades. Novel approaches to psychological interventions have also been witnessed. One intervention (non-RCT) study on effects on general counseling has been reported from India. PMID:27570336

  3. Factors contributing to suboptimal rates of childhood vaccinations in Vermont.

    Science.gov (United States)

    Kelley, Catherine A; Velazco, Cristine S; Delaney, Thomas V; Bensimhon, Adam; Huang, Kuang-Ning; Jarvis, Paul R; Jolin, Jonathan S; Schaberg, Kurt B; Burke, Marianne; Finley, Christine; Carney, Jan K

    2015-12-01

    Childhood immunizations are invaluable in preventing contagious diseases. Nonetheless, vaccines have become increasingly controversial with growing numbers of caregivers refusing to vaccinate their children. The percentage of fully vaccinated children in Vermont is one of the lowest nationally. This study set out to determine Vermont caregivers' attitudes toward immunizations to better explain why the percentage of fully vaccinated children has fallen in Vermont. A survey regarding caregivers' health care knowledge about children, their vaccination concerns, and their children's vaccination status was sent to participants in the Vermont Women, Infants and Children's Program from two districts. In total, 83% (n = 379) of respondents reported their children received all recommended vaccinations for their age. Respondents who considered themselves highly knowledgeable regarding their children's health care and confident about the safety of vaccinations were significantly associated with reporting their children as being current on vaccinations and with their intent to continue vaccinations. Respondents indicated highest concern regarding the safety and number of vaccinations administered during one visit. Primary care providers were indicated as important resources for addressing concerns about vaccinations and health care knowledge of children. The results help to understand low vaccination rates in Vermont and can be used for targeting health campaigns to improve vaccination rates. PMID:24821076

  4. A Study to Assess the Vaccination Coverage of University Students in Mumbai, India

    OpenAIRE

    Limaye, Vaidehi; Limaye, Dnyanesh; Fortwengel, Gerhard

    2016-01-01

    Immunization is the most cost-effective intervention for infectious diseases, which are the major cause of morbidity and mortality worldwide. Vaccines not only protect the individual who is vaccinated but also reduce the burden of infectious vaccine-preventable diseases for the entire community.1 Adult vaccination is very important given that >25% of mortality is due to infectious diseases.2 There is a scarcity of information on the vaccination status of young adults and the role of socioecon...

  5. Scoliosis surgery - child

    Science.gov (United States)

    Spinal curvature surgery - child; Kyphoscoliosis surgery - child; Video-assisted thoracoscopic surgery - child; VATS - child ... Before surgery, your child will receive general anesthesia. This will make your child unconscious and unable to feel pain ...

  6. Role of vaccination in economic growth.

    Science.gov (United States)

    Quilici, Sibilia; Smith, Richard; Signorelli, Carlo

    2015-01-01

    The health of a population is important from a public health and economic perspective as healthy individuals contribute to economic growth. Vaccination has the potential to contribute substantially to improving population health and thereby economic growth. Childhood vaccination programmes in Europe can offer protection against 15 important infectious diseases, thus preventing child fatalities and any serious temporary and permanent sequelae that can occur. Healthy children are more able to participate in education, thus preparing them to become healthy and productive adults. Vaccination programmes can also prevent infectious diseases in adolescents, thus allowing them to continue their development towards a healthy adulthood. Protecting adults against infectious diseases ensures that they can fully contribute to productivity and economic development by avoiding sick leave and lower productivity. Vaccination in older adults will contribute to the promotion of healthy ageing, enabling them to assist their familiy with, for instance, childcare, and also help them avoid functional decline and the related impacts on health and welfare expenditure. Effective vaccination programmes for all ages in Europe will thus contribute to the European Union's 2020 health and economic strategies. Indeed, beyond their impact on healthcare resources and productivity, reductions in mortality and morbidity also contribute to increased consumption and gross domestic product. Therefore, assessment of the value of vaccines and vaccination needs to consider not just the direct impact on health and healthcare but also the wider impact on economic growth, which requires a macroeconomic analysis of vaccination programmes.

  7. Does knowledge about antiretroviral therapy and mother-to-child transmission affect the relationships between HIV status and fertility preferences and contraceptive use? New evidence from Nigeria and Zambia.

    Science.gov (United States)

    Bankole, Akinrinola; Biddlecom, Ann E; Dzekedzeke, Kumbutso; Akinyemi, Joshua O; Awolude, Olutosin; Adewole, Isaac F

    2014-09-01

    The increasing availability of antiretroviral therapy (ART) and drug regimens to prevent mother-to-child transmission (PMTCT) has probably changed the context of childbearing for people living with HIV. Using data from 2009-2010 community-based surveys in Nigeria and Zambia, this study explores whether women's knowledge about ART and PMTCT influences the relationship between HIV status and fertility preferences and contraceptive behaviour. The findings show that women living with HIV are more likely to want more children in Nigeria and to want to limit childbearing in Zambia compared with HIV-negative women. While there is no significant difference in contraceptive use by women's HIV status in the two countries, women who did not know their HIV status are less likely to use contraceptives relative to women who are HIV-negative. Knowledge about ART reduces the childbearing desires of HIV-positive women in Nigeria and knowledge about PMTCT increases desire for more children among HIV-positive women in Zambia, as well as contraceptive use among women who do not know their HIV status. The findings indicate that knowledge about HIV prevention and treatment services changes how living with HIV affects childbearing desires and, at least in Zambia, pregnancy prevention, and highlight the importance of access to accurate knowledge about ART and PMTCT services to assist women and men to make informed childbearing decisions. Knowledge about ART and PMTCT should be promoted not only through HIV treatment and maternal and newborn care facilities but also through family planning centres and the mass media.

  8. Progress towards meningitis prevention in the conjugate vaccines era

    Directory of Open Access Journals (Sweden)

    Cristina Aparecida Borges Laval

    2003-10-01

    Full Text Available Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib, and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect and of their carriage status (indirect effect. We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.

  9. Influenza vaccination

    DEFF Research Database (Denmark)

    Østerhus, Sven Frederick

    2015-01-01

    The Cochrane Library was systematically searched for meta-analyses regarding influenza vaccination of various populations, both healthy and sick. An effect in reducing the number of cases of influenza, influenza-like illness or complications to influenza was found in some studies, but, generally,......, the quality of the studies was low, and several studies lacked hard clinical endpoints. Data on adverse effects were scarce. More randomised controlled trials investigating the effects of influenza vaccination are warranted.......The Cochrane Library was systematically searched for meta-analyses regarding influenza vaccination of various populations, both healthy and sick. An effect in reducing the number of cases of influenza, influenza-like illness or complications to influenza was found in some studies, but, generally...

  10. Survey on the Immunization Status of Category B Vaccine among Children Aged 1 to 2 Years in China%中国1~2岁儿童第二类疫苗接种现况调查分析

    Institute of Scientific and Technical Information of China (English)

    郑景山; 曹玲生; 王华庆; 曹雷; 郭世成; 阿克忠; 王雷; 余文周; 袁平; 姜柯羽; 张国民

    2012-01-01

    目的 了解中国(未包含香港、澳门特别行政区和台湾地区,下同)1~2岁儿童第二类疫苗的接种特征,为规范管理第二类疫苗提供参考.方法 在31个省(自治区、直辖市)和新疆生产建设兵团各随机抽取一个县(区、市、旗、师,下同),在调查县采用按容量比例概率抽样法,入户调查1岁、2岁各75名儿童的第二类疫苗接种情况.结果 共调查4681名1岁、2岁儿童,2875名(61.42%)接种过第二类疫苗;其中接种水痘减毒活疫苗、b型流行性感冒(流感)嗜血杆菌结合疫苗、口服轮状病毒减毒活疫苗、流感疫苗、7价肺炎球菌结合疫苗5种儿童常用第二类疫苗的比例,分别为46.93%、45.31%、23.67%、17.47%和9.91%:接种替代免疫规划的乙型肝炎疫苗、脊髓灰质炎灭活疫苗、无细胞百日咳-白喉-破伤风联合疫苗、麻疹-流行性腮腺炎-风疹联合减毒活疫苗、A+C群脑膜炎球菌多糖结合疫苗、流行性乙型脑炎灭活疫苗、甲型肝炎灭活疫苗等第二类疫苗的比例,分别为0.70%、0.53%、7.67%、2.26%、5.70%、2.34%、11.66%.经济发展较快地区儿童接种第二类疫苗比例较高;需要全程接种多剂次的第二类疫苗免疫程序执行的完整性较差.结论 中国1~2岁儿童第二类疫苗的预防接种服务较为普遍,需要规范第二类疫苗预防接种服务管理.%Objective To analysis the immunization status of category B vaccine (chargeable vaccine) among children aged 1 to 2 years, and to provide reference for the management of category B vaccine. Methods 150 children aged 1 to 2 years from each selected county were investigated by probability proportional to size ( PPS) sampling method, to understand their immunization status for category B vaccine. Results 61.41% (2875) of 4681 children aged 1-2 years old received category B vaccines. Among 4681 children, the coverage of varicella attenuated live vaccine

  11. Underlying Constructs in the Development and Institutionalization of the Child Drama Field.

    Science.gov (United States)

    Woodson, Stephani Etheridge

    1998-01-01

    Examines the invisible incorporation of constructions from the Victorian and Progressive eras regarding children, women, and theatre art, into the field of child drama. Discusses child drama as a moral calling; women and the gendered status of child drama; child drama as an amateur field; child drama as education in democracy; and the construction…

  12. Vaccination priorities.

    Science.gov (United States)

    Steffen, Robert; Baños, Ana; deBernardis, Chiara

    2003-02-01

    Selection of immunizations should be based on requirements and on risk of infection. According to the International Health Regulations, many countries require yellow fever vaccination and proof thereof as the International Certificate of vaccination. Additionally selected countries require proof of vaccination against cholera and meningococcal disease. A consultation for travel health advice is always an opportunity to ascertain that routine immunizations have been performed. Recommended immunizations often are more important for traveller's health than the required or routine ones. The most frequent vaccine preventable infection in non-immune travellers to developing countries is hepatitis A with an average incidence rate of 0.3% per month; in high risk backpackers or foreign-aid-volunteers this rate is 2.0%. Many immunizations are recommended for special risk groups only: there is a growing tendency in many countries to immunize all young travellers to developing countries against hepatitis B, as it is uncertain who will voluntarily or involuntarily get exposed. The attack rate of influenza in intercontinental travel is estimated to be 1%. Immunity against poliomyelitis remains essential for travel to Africa and parts of Asia. Many of the 0.2-0.4% who experience an animal bite are at risk of rabies. Typhoid fever is diagnosed with an incidence rate of 0.03% per month among travellers to the Indian subcontinent, North and West Africa (except Tunisia), and Peru, elsewhere this rate is 10-fold lower. Meningococcal disease, Japanese encephalitis, cholera and tuberculosis have been reported in travellers, but these infections are rare in this population. Although no travel health vaccine is cost beneficial, most professionals will offer protection against the frequent risks, while most would find it ridiculous to use all available vaccines in every traveller. It is essentially an arbitrary decision made on the risk level one wishes to recommend protection--but the

  13. Vaccine Vexes

    Institute of Scientific and Technical Information of China (English)

    Maya; Reid

    2011-01-01

    IT’S always nice when expectations are exceeded by half a billion dollars.This was the case for the Global Alliance for Vaccines and Immunization(GAVI) at its fundraising conference in June.A public-private initiative,GAVI,which works to ensure children in developing countries receive crucial vaccinations,had gone into the meeting hoping to net $3.7 billion.They came away with $4.3 billion,"despite the fact that donors everywhere are coping with budget crises," as Bill Gates

  14. o Explore the Child Vaccination Common Adverse Reactions and Processing Method%探究儿童预防接种常见的不良反应及处理方法

    Institute of Scientific and Technical Information of China (English)

    田金云

    2015-01-01

    目的 探究儿童预防接种常见的不良反应及处理方法,保证预防接种的安全性.方法 回顾性分析我县各接种门诊2014年对7岁及以下儿童进行预防接种时不良反应的发生情况及处理方法的临床资料.结果 355例预防接种儿童共发生不良反应11例,经过及时有效的处理后,全部儿童的临床症状均在5 d内获得明显改善.结论 加强预防接种不良反应的观察工作,并及时处理相应症状,有利于提高预防接种的安全性,保证儿童的身心健康.%Objective To explore children's vaccination common adverse reactions and processing method, ensure the safety of vaccination. Methods A retrospective analysis of our county's vaccination outpatient service 2014 on children under 7 years old,and the adverse reaction during the vaccination and treatment Methods of clinical data. Results 355 cases of vaccination of children with 11 cases of adverse reactions, after the timely and effective treatment,clinical symptoms of all the children get significant improvement in the 5 d. Conclusion To strengthen the observation of vaccination reactions work, and timely handle the corresponding symptoms,to improve the safety of vaccination, and ensure the physical and mental health of children.

  15. Prevalence and factors associated with parental concerns about development detected by the Parents’ Evaluation of Developmental Status (PEDS) at 6-month, 12-month and 18-month well-child checks in a birth cohort

    Science.gov (United States)

    Woolfenden, Susan; Eapen, Valsamma; Jalaludin, Bin; Hayen, Andrew; Kemp, Lynn; Dissanyake, Cheryl; Hendry, Alexandra; Axelsson, Emma; Overs, Bronwyn; Eastwood, John; Črnčec, Rudi; McKenzie, Anne; Beasley, Deborah; Murphy, Elisabeth; Williams, Katrina

    2016-01-01

    Objectives Early identification of developmental vulnerability is vital. This study aimed to estimate the prevalence of moderate or high developmental risk on the Parents' Evaluation of Developmental Status (PEDS) at 6-month, 12-month and 18-month well-child checks; identify associated risk factors; and examine documentation of the PEDS at well-child checks. Design, participants A prospective birth cohort of 2025 children with 50% of those approached agreeing to participate. Demographic data were obtained via questionnaires and linked electronic medical records. Telephone interviews were conducted with parents to collect PEDS data. Primary and secondary outcomes Multiple logistic regression analyses identified risk factors for moderate or high developmental risk on the PEDS. A Cumulative Risk Index examined the impact of multiple risk factors on developmental risk and documentation of the PEDS at the well-child checks. Results Of the original cohort, 792 (39%) had 6-month, 649 (32%) had 12-month and 565 (28%) had 18-month PEDS data. Parental concerns indicating moderate or high developmental risk on the PEDS were 27% (95% CI 24 to 30) at 6 months, 27% (95% CI 24 to 30) at 12 months and 33% (95% CI 29 to 37) at 18 months. Factors associated with moderate or high developmental risk were perinatal risk (OR 12 months: 1.7 (95% CI 1.1 to 2.7)); maternal Middle Eastern or Asian nationality (OR 6 months: 1.6 (95% CI 1.1 to 2.4)), (OR 12 months: 1.7 (95% CI 1.1 to 2.7)); and household disadvantage (OR 6 months: 1.5 (95% CI 1.0 to 2.2). As the number of risk factors increased the odds increased for high or moderate developmental risk and no documentation of the PEDS at well-child checks. Conclusions Children with multiple risk factors are more likely to have parental concerns indicating developmental vulnerability using the PEDS and for these concerns to not be documented. PMID:27609853

  16. 湖南省妇幼保健机构保健工作现状调查%Investigation on health status of maternal and child care institutions in Hunan province

    Institute of Scientific and Technical Information of China (English)

    刘智昱; 杜其云

    2009-01-01

    To observe the health status of maternal and child care institutions in Hunan province, provide scientific ev-idence for decision-making on maternal and child care. Methods: A survey was conducted through national management information web-based reporting system of women and children health facilities, 137 maternal and child health care institutions were investigated, including a provincial-level agency, 14 state-level agencies and 122 county-level agencies. The contents included basic status of maternal and child health care, human resources, health services and medical technologies, group health care work. The data were analyzed via SPSS 15.0 and Excel 2003. Results: ①Basie status: the average amount of people participating in maternal and child health care was 15, with 124 of pro-vincial-level, 17 of state-level and 14 of county-level. ②Healtheare clinic: the average person-time of the out-patients receiving ma-ternal health care was 6 475, while the average person-time of the out-patients receiving child health care was 7 821. ③The development of health care: the proportions of maternal health care management, prenatal diagnosis management, reproductive health and family plan-ning, assisted reproductive health were 98.5%, 12. 4%, 84. 7% and 6. 6%, respectively; more than 70% of the institutions carried out growth and development of children , child nutrition, child development and the promotion of high-risk infants; training courses were con-dueted for 6 times, 429 people-times were trained and 26 people-times were received for further education, 646 people-times went to grass roots. Conclusion: The investment of government agencies is inadequate and the human resources should be strengthened, at the same time, group health should be further in-depth, and information management should be improved.%目的:了解湖南省各级妇幼保健机构保健工作现状,为各级卫生行政部门的决策提供科学依据.方法:采用全国妇幼卫

  17. Replicating vaccines

    Science.gov (United States)

    Early work on fish immunology and disease resistance demonstrated fish (like animals and humans) that survived infection were typically resistant to re-infection with the same pathogen. The concepts of resistance upon reinfection lead to the research and development of replicating (live) vaccines in...

  18. Malaria vaccine.

    Science.gov (United States)

    1994-05-01

    Some have argued that the vaccine against malaria developed by Manuel Pattaroyo, a Colombian scientist, is being tested prematurely in humans and that it is unlikely to be successful. While the Pattaroyo vaccine has been shown to confer protection against the relatively mild malaria found in Colombia, doubts exist over whether it will be effective in Africa. Encouraging first results, however, are emerging from field tests in Tanzania. The vaccine triggered a strong new immune response, even in individuals previously exposed to malaria. Additional steps must be taken to establish its impact upon mortality and morbidity. Five major trials are underway around the world. The creator estimates that the first ever effective malaria vaccine could be available for widespread use within five years and he has no intention of securing a patent for the discovery. In another development, malaria specialists from 35 African countries convened at an international workshop in Zimbabwe to compare notes. Participants disparaged financial outlays for the fight against malaria equivalent to 2% of total AIDS funding as insufficient; noted intercountry differences in prevention, diagnosis, and treatment; and found information exchange between anglophone and francophone doctors to be generally poor. PMID:12287671

  19. Vexing Vaccines

    Science.gov (United States)

    Bowman, Darcia Harris

    2004-01-01

    Schools play a key role in ensuring that children are being immunized against diseases, but conflicting research is making enforcement difficult. This article discusses a growing trend of vaccine avoidance and the endless supply of conflicting information and research about immunization safety. Despite the controversy, many people appear to accept…

  20. [Vaccination safety and media publicity strategy].

    Science.gov (United States)

    Tan, Jibin; Guo, Xiaomin; Li, Keli; Zhang, Xiumin

    2016-03-01

    Due to the over negative report of adverse event following immunization (AEFI) by media, some people began to question the safety of vaccination. Date published since 2005 were collected by literature retrieval, mainly including relative AEFI date, current status of media report of AEFI, public awareness about AEFI. Public concern about the vaccination safety mainly focused on the serious diseases which might be caused, influence on immune system. Media' s over negative reactions to AEFI and lack of related knowledge in general public have led to the public' s concern about vaccination safety. Vaccination is the most economical and effective measure for the prevention of diseases and AEFI incidence rate is very low. Therefore, it is necessary for media to give more positive report about vaccination safety.

  1. Determining vaccination frequency in farmed rainbow trout using Vibrio anguillarum O1 specific serum antibody measurements.

    Directory of Open Access Journals (Sweden)

    Lars Holten-Andersen

    Full Text Available BACKGROUND: Despite vaccination with a commercial vaccine with a documented protective effect against Vibrio anguillarum O1 disease outbreaks caused by this bacterium have been registered among rainbow trout at Danish fish farms. The present study examined specific serum antibody levels as a valid marker for assessing vaccination status in a fish population. For this purpose a highly sensitive enzyme-linked immunosorbent assay (ELISA was developed and used to evaluate sera from farmed rainbow trout vaccinated against V. anguillarum O1. STUDY DESIGN: Immune sera from rainbow trout immunised with an experimental vaccine based on inactivated V. anguillarum O1 bacterin in Freund's incomplete adjuvant were used for ELISA optimisation. Subsequently, sera from farmed rainbow trout vaccinated with a commercial vaccine against V. anguillarum were analysed with the ELISA. The measured serum antibody levels were compared with the vaccine status of the fish (vaccinated/unvaccinated as evaluated through visual examination. RESULTS: Repeated immunisation with the experimental vaccine lead to increasing levels of specific serum antibodies in the vaccinated rainbow trout. The farmed rainbow trout responded with high antibody levels to a single injection with the commercial vaccine. However, the diversity in responses was more pronounced in the farmed fish. Primary visual examinations for vaccine status in rainbow trout from the commercial farm revealed a large pool of unvaccinated specimens (vaccination failure rate=20% among the otherwise vaccinated fish. Through serum analyses using the ELISA in a blinded set-up it was possible to separate samples collected from the farmed rainbow trout into vaccinated and unvaccinated fish. CONCLUSIONS: Much attention has been devoted to development of new and more effective vaccines. Here we present a case from a Danish rainbow trout farm indicating that attention should also be directed to the vaccination procedure in

  2. Investigation on the psychological status and its influencing factors in parents lost their only child%失独者的心理健康状况及其影响因素

    Institute of Scientific and Technical Information of China (English)

    杭荣华; 陶金花; 张文嘉; 董亚歌; 张雪娇

    2015-01-01

    Objective:To investigate the psychological status and its influencing factors in parents lost their only child .Methods:Symptom Check list 90 (SCL-90),Simplified Coping Style Questionnaire(SCSQ)and General Self-Efficacy Scale (GSES) were applied to surveying on 186 parents lost their only child(observational group) and another 200 counterparts(control subjects) with general condition inventory.Results:Compared with the controls,the ob-servational group scored totally higher on individual components on SCL-90 and negative coping styles,yet lower on items of positive coping styles,general self-efficacy,and availability of social support and auto-support.The two groups were significantly different(P<0.05 or P<0.01).Total scoring on SCL-90 for observational group was positively correlated with negative coping styles,whereas negatively with marriage status and living status,religious belief, willingness to give birth to another child,positive coping styles,availability of auto-support and objective support as well as total scores on social support and self-efficacy(P<0.05 or P <0.01).Positive coping styles,marriage and spouse living status,religious belief were positive contribution to mental health,whereas negative coping styles were negatively associated with mental health.Conclusion:The mental health levels are overall lower in parents lost their only child,and associated to a certain extent with their current marital status,religious beliefs,possibility to give birth to another child,coping style to the bereavement,availability of social support and self-efficacy.Coping styles can be predictive role in estimation of the mental health status in this popula-tion.%目的:研究失独者的心理健康状况及其影响因素。方法:采用一般情况调查表、90项症状清单( SCL-90)、社会支持评定量表( SSRS)、简易应对方式问卷( SCSQ)和一般自我效能感量表( GSES)对186名失独者(研究组)和200名非失独者

  3. FIV vaccine development and its importance to veterinary and human medicine: a review FIV vaccine 2002 update and review.

    Science.gov (United States)

    Uhl, E W; Heaton-Jones, T G; Pu, R; Yamamoto, J K

    2002-12-01

    Feline immunodeficiency virus (FIV) is a natural infection of domestic cats that results in acquired immunodeficiency syndrome resembling human immunodeficiency virus (HIV) infection in humans. The worldwide prevalence of FIV infection in domestic cats has been reported to range from 1 to 28%. Hence, an effective FIV vaccine will have an important impact on veterinary medicine in addition to being used as a small animal AIDS model for humans. Since the discovery of FIV reported in 1987, FIV vaccine research has pursued both molecular and conventional vaccine approaches toward the development of a commercial product. Published FIV vaccine trial results from 1998 to the present have been compiled to update the veterinary clinical and research communities on the immunologic and experimental efficacy status of these vaccines. A brief report is included on the outcome of the 10 years of collaborative work between industry and academia which led to recent USDA approval of the first animal lentivirus vaccine, the dual-subtype FIV vaccine. The immunogenicity and efficacy of the experimental prototype, dual-subtype FIV vaccine and the efficacy of the currently approved commercial, dual-subtype FIV vaccine (Fel-O-Vax FIV) are discussed. Potential cross-reactivity complications between commercial FIV diagnostic tests, Idexx Snap Combo Test and Western blot assays, and sera from previously vaccinated cats are also discussed. Finally, recommendations are made for unbiased critical testing of new FIV vaccines, the currently USDA approved vaccine, and future vaccines in development. PMID:12459160

  4. Fish Vaccines in Aquaculture

    Science.gov (United States)

    Vaccination is a proven, cost-effective method to prevent infectious diseases in animals. Current fish vaccines can be categorized as killed fish vaccines or modified live vaccines. The major advantage of live vaccine is their ability to stimulate both cell-mediated and humoral immune responses for ...

  5. South Asia symposium on pneumococcal disease and the promise of vaccines - Meeting report.

    Science.gov (United States)

    Kumar, Rakesh; Arora, Narendra; Santosham, Mathuram

    2016-05-17

    Despite the licensure of the pneumococcal conjugate vaccine (PCV) in the US and other Western countries for over 14 years, as of September 2014 only 4 South Asian countries were using PCV in their universal immunization program. To generate momentum toward addressing this issue a "South Asia symposium on pneumococcal disease and the promise of vaccines" was organized just prior to the 9th international symposium on pneumococci and pneumococcal diseases held in India recently. Leading scientists, program managers, and decision makers including ministry officials from the region participated in the meeting. The participants discussed available data on pneumococcal disease burden in South Asia, surveillance methods, efficacy and safety of pneumococcal conjugate vaccines (PCV), the status of PCV introduction, programmatic challenges in introducing PCV and available data on the impact of PCV in South Asia and globally. There was a strong consensus that available data on disease burden and the global experience with PCV justified the introduction PCV in all Asian countries in order to accelerate the gains in child survival in the region. PMID:27026150

  6. The impact of BCG vaccination on tuberculin skin test responses in children is age dependent: evidence to be considered when screening children for tuberculosis infection

    Science.gov (United States)

    Seddon, James A; Paton, James; Nademi, Zohreh; Keane, Denis; Williams, Bhanu; Williams, Amanda; Welch, Steven B; Liebeschutz, Sue; Riddell, Anna; Bernatoniene, Jolanta; Patel, Sanjay; Martinez-Alier, Nuria; McMaster, Paddy; Kampmann, Beate

    2016-01-01

    Background Following exposure to TB, contacts are screened to target preventive treatment at those at high risk of developing TB. The UK has recently revised its recommendations for screening and now advises a 5 mm tuberculin skin test (TST) cut-off irrespective of age or BCG status. We sought to evaluate the impact of BCG on TST responses in UK children exposed to TB and the performance of different TST cut-offs to predict interferon γ release assay (IGRA) positivity. Methods Children vaccination on TST positivity was evaluated in IGRA-negative children, as was the performance of different TST cut-offs to predict IGRA positivity. Results Of 422 children recruited (median age 69 months; IQR: 32–113 months), 300 (71%) had been vaccinated with BCG. BCG vaccination affected the TST response in IGRA-negative children less than 5 years old but not in older children. A 5 mm TST cut-off demonstrated good sensitivity and specificity in BCG-unvaccinated children, and an excellent negative predictive value but was associated with low specificity (62.7%; 95% CI 56.1% to 69.0%) in BCG-vaccinated children. For BCG-vaccinated children, a 10 mm cut-off provided a high negative predictive value (97.7%; 95% CI 94.2% to 99.4%) with the positive predictive value increasing with increasing age of the child. Discussion BCG vaccination had little impact on TST size in children over 5 years of age. The revised TST cut-off recommended in the recent revision to the UK TB guidelines demonstrates good sensitivity but is associated with impaired specificity in BCG-vaccinated children. PMID:27335104

  7. 乙肝疫苗联合乙肝免疫球蛋白阻断乙肝母婴传播的效果评价%Clinical Evaluation of Hepatitis B Vaccine Combined with Hepatitis B Immunoglobulinin in Blocking Mother-to-child Transmission of Hepatitis B Virus

    Institute of Scientific and Technical Information of China (English)

    李倩; 李开艳; 王丽颖

    2015-01-01

    Objective To evaluate the effects of Hepatitis B vaccine combined with Hepatitis B immunoglobulin ( HBIG) in bloc-king mother-to-child transmission of hepatitis B virus ( HBV ) .Methods One hundred and eighty-six cases of HBsAg positive pregnant women were randomly divided into two groups .In hepatitis B vaccine combined with hepatitis B immunoglobulinin group ,93 cases received in-tramuscular injection of HBIG (200IU per time once one week for 4 weeks) and hepatitis B vaccine (20μg per time once one week for 4 weeks,at the different positions) at 24,28,32,36 week during pregnancy.In theHBIG group,93 cases were only given HBIG at the same time and the dose was unchanged .The HBV marker and content of HBV-DNA in the blood samples of mothers and their neonates were tested by enzyme-linked immunosorbent assay and fluorescence quantitative polymerase chain reaction (FQPCR) respectively.Results Compared with the HBIG group,content of HBV-DNA of hepatitis B vaccine combined with HBIG group were significantly decreased .The detection rate of HBsAb of hepatitis B vaccine combined with HBIG group was 69.89% and was significantly higher than those (45.16%) in the HBIG group.The incidence of intrauterine infection were 5.38% and 12.90% respectively and there were significant difference between two groups.Conclusion Hepatitis B vaccine combined with HBIG during pregnancy can notably reduce the incidence of intrauterine infection and its effect in blocking mother-to-child transmission of hepatitis B virus is better than that of HBIG .%目的:评价乙肝疫苗联合乙肝免疫球蛋白( HBIG)阻断乙肝母婴传播的综合治疗疗效。方法对186例孕检的孕妇HBsAg阳性者随机分为治疗组(93例)和对照组(93例),治疗组分别于孕24周、28周、32周、36周肌肉注射HBIG共4次,每次200IU,同时在不同部位注射乙肝疫苗20μg,共4次;对照组在同时间、同剂量单用HBIG。采用酶联免疫吸附测定法,检

  8. The mucosal immune response to plant-derived vaccines.

    Science.gov (United States)

    Hefferon, Kathleen Laura

    2010-10-01

    Transgenic plants present enormous potential as one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary and agricultural uses. Heat-stable plant-derived vaccines that are administered orally could in effect enhance vaccine coverage in children and infants, particularly in developing countries. Here we discuss the current status of plant-derived vaccines and their potential to champion the battle against infectious diseases in the least developed countries.

  9. Invasive pneumococcal infection despite 7-valent conjugated vaccine

    Directory of Open Access Journals (Sweden)

    Sebastien Joye

    2013-03-01

    Full Text Available Despite good cover with 7-valent vaccination, invasive pneumococcal infections may still be misdiagnosed and may lead to lifethreatening situations or death in young children. New serotypes are emerging and, therefore, clinicians must keep a high level of suspicion in young children regardless of their vaccination status. We report three cases of invasive pneumococcal infection due to new serotypes not covered by the 7-valent conjugated vaccine, two of which led children to death.

  10. Introduction of human papillomavirus vaccination in Nordic countries

    DEFF Research Database (Denmark)

    Sander, Bente Braad; Rebolj, Matejka; Valentiner-Branth, Palle;

    2012-01-01

    Cervical screening has helped decrease the incidence of cervical cancer, but the disease remains a burden for women. Human Papillomavirus (HPV) vaccination is now a promising tool for control of cervical cancer. Nordic countries (Denmark, Finland, Greenland, Iceland, Norway and Sweden......) are relatively wealthy with predominantly publicly paid health care systems. The aim of this paper was to provide an update of the current status of introduction of HPV vaccine into the childhood vaccination programs in this region....

  11. Current challenges in the development of vaccines for pneumonic plague

    OpenAIRE

    Smiley, Stephen T.

    2008-01-01

    Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we currently lack a safe and effective pneumonic plague vaccine. These facts raise concern that Y. pestis may be exploited as a bioweapon. Here, I review the history and status of plague vaccine research and advocate that pneumonic plague vaccines should strive to prime both humoral and cellular immunity.

  12. Child Care and Child Nutrition

    Science.gov (United States)

    Karolak, Eric

    2009-01-01

    The weak economy is challenging the child care program budget. Fluctuations in enrollment come up against rising costs making every penny count. So for many reasons a federal program that helps defray the costs of snacks and meals in child care programs is particularly important and timely. In this article, the author pushes for the…

  13. Vaccines Stop Illness

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Vaccines Stop Illness Past Issues / Spring 2008 Table of ... meningitis won't infect, cripple, or kill children. Vaccine Safety In light of recent questions about vaccine ...

  14. Vaccines Stop Illness

    Science.gov (United States)

    ... page please turn JavaScript on. Feature: Diseases and Vaccinations Vaccines Stop Illness Past Issues / Spring 2015 Table ... if we take away the protection given by vaccination, more and more people will be infected and ...

  15. Vaccinations and HIV

    Science.gov (United States)

    ... 23, 2014 Select a Language: Fact Sheet 207 Vaccinations and HIV WHAT ARE VACCINATIONS? WHAT’S DIFFERENT FOR ... your viral load within 4 weeks of any vaccination. Flu shots have been studied more than any ...

  16. Vaccinations during Pregnancy

    Science.gov (United States)

    ... you do need any vaccinations, wait 1 month after you get them before you try to get pregnant. ... vaccine during pregnancy, you can get it right after you give birth. Getting the Tdap vaccine soon after ...

  17. Effectiveness of BCG Vaccination in Prevention of Childhood Tuberculosis: A Prospective Study from Kishanganj, Bihar

    Directory of Open Access Journals (Sweden)

    Kashif Shahnawaz, Goutam Sarkar, Palash Das, Mausumi Basu, Biman Roy

    2013-01-01

    Full Text Available Introduction: BCG vaccine has shown consistently high efficacy against childhood tubercular meningitis and miliary tuberculosis and other mycobacterial diseases. It is considered to be a safe vaccine with a low incidence of adverse effects. Efficacy of BCG vaccine found in different clinical trials is variable in different geography. Objectives: Study was done to assess the efficacy of BCG vac-cine. Materials and Methods: All the children who were less than three years of age and were previously BCG vaccinated and not-vaccinated, were included in this study. A total of sixty (60 vaccinated children and sixty non-vaccinated children were selected. These children were followed up prospectively for 24 months, at the end of which, it was seen whether they developed tuberculosis or not. Results: Out of these 60 children in both the cases and control groups, total number of BCG vaccinated children who developed TB were 4 (i.e. 6.6% and total number of Non-BCG vaccinated children who developed TB were 12 (i.e. 20%. Thus, the efficacy of BCG vaccine calculated in our study was 67%. Conclusion: Most studies in different parts of the world have shown that the efficacy of BCG vaccine varies from zero to eigh-ty percent. This study favors the efficacy of BCG vaccine. This vaccination strategy will be favorable for our children. Creation of awareness among the parents and family members for an early administration of BCG vaccine after child birth can be recom-mended.

  18. Influenza Vaccines

    OpenAIRE

    Ellebedy, A. H.; Webby, R J

    2009-01-01

    Influenza A viruses pose a substantial threat to the human population whether by purposeful manipulation and release or by the natural process of interspecies transmissions from animal reservoirs. The challenge with preparing for these events with vaccination strategies is that the best forms of protective immunity target the most variably of the viral proteins, hemagglutinin. Add to this even just the natural extent of variation in this protein and the challenges to vaccinologists become gre...

  19. Race/Ethnic and Nativity Disparities in Child Overweight in the United States and England

    OpenAIRE

    2012-01-01

    Child overweight is a growing problem in wealthy countries. There is also evidence that child overweight varies by race/ethnicity and socioeconomic status. In this article, the authors use data from two recent birth cohort studies in the United States and England to address four questions: (1) Are race/ethnic and immigrant status associated with child overweight? (2) Is the association between socioeconomic status and child overweight similar across race/ethnic and nativity subgroups? (3) Doe...

  20. Progress and controversies in developing cancer vaccines

    Directory of Open Access Journals (Sweden)

    Speiser Daniel E

    2005-04-01

    Full Text Available Abstract Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2 and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, and there has been substantial progress in identifying shared antigens recognized by T cells, in developing vaccine approaches that induce antigen-specific T cell responses in cancer patients, and in developing new technology for monitoring immune responses in various human tissue compartments. Dramatic clinical regressions of human solid tumors have occurred with some cancer vaccines, but the rate of those responses remains low. This article is part of a 2-part point:counterpoint series on peptide vaccines and adoptive therapy approaches for cancer. The current status of cancer vaccination, and associated challenges, are discussed. Emphasis is placed on the need to increase our knowledge of cancer immunobiology, as well as to improve monitoring of cellular immune function after vaccination. Progress in both areas will facilitate development of effective cancer vaccines, as well as of adoptive therapy. Effective cancer vaccines promise to be useful for treatment and prevention of cancer at low cost and with low morbidity.

  1. An assessment of measles vaccine effectiveness, Australia, 2006-2012

    Directory of Open Access Journals (Sweden)

    Alexis Pillsbury

    2015-07-01

    Full Text Available Objective: Vaccine effectiveness analysis serves as a critical evaluation for immunization programmes and vaccination coverage. It also contributes to maintaining public confidence with the vaccine providers. This study estimated measles vaccine effectiveness at the population level using Australian national notifications data between 2006 and 2012. Methods: Notification data were obtained from the National Notifiable Diseases Surveillance System. Vaccination status was classified according to whether a case had received zero, one or two doses of measles-containing vaccine. Cases aged less than 1 year and those with unknown vaccination status were excluded. All children with disease onset between 1 January 2006 and 31 December 2012 who were born after 1996 were included. Cases were matched to controls extracted from the Australian Childhood Immunisation Register according to date of birth and jurisdiction of residence. Vaccine effectiveness was estimated by conditional logistic regression. Sensitivity analyses were conducted to test data robustness. Results: Vaccine effectiveness was estimated at 96.7% (95% confidence interval [CI]: 94.5–98.0% for one dose and 99.7% (95% CI: 99.2–99.9% for two doses of measles vaccine. For at least one dose, effectiveness was estimated at 98.7% (95% CI: 97.9–99.2%. Sensitivity analyses did not significantly alter the base estimates. Discussion: Vaccine effectiveness estimates suggested that the measles vaccine was protective at the population level between 2006 and 2012. However, vaccination coverage gaps may have contributed to recent measles outbreaks and may represent a serious barrier for Australia to maintain measles elimination status.

  2. Human Papillomavirus Vaccination Requirements in US Schools: Recommendations for Moving Forward.

    Science.gov (United States)

    North, Anna L; Niccolai, Linda M

    2016-10-01

    Safe and effective human papillomavirus (HPV) vaccines have been available and recommended for adolescents for a decade in the United States, yet vaccination rates remain suboptimal. School entry requirements have increased uptake of other vaccines for adolescents and made coverage more equitable. However, only 3 jurisdictions require HPV vaccine for school. We summarize the current status of HPV vaccine requirements and discuss the rationales for and against these policies. The rationales for requirements include HPV vaccine efficacy and safety, effectiveness of requirements for increasing vaccine uptake and making it more equitable, and use of requirements as "safety nets" and to achieve herd immunity. The rationales against requirements include low parental acceptance of HPV vaccine, the financial burden on educational systems and health departments, and the possibility for alternatives to increase vaccine uptake. Many challenges to HPV vaccine requirements are addressable, and we conclude with recommendations on how to approach these challenges. PMID:27552264

  3. Dengue vaccine: an update on recombinant subunit strategies.

    Science.gov (United States)

    Martin, J; Hermida, L

    2016-03-01

    Dengue is an increasing public health problem worldwide, with the four serotypes of the virus infecting over 390 million people annually. There is no specific treatment or antiviral drug for dengue, and prevention is largely limited to controlling the mosquito vectors or disrupting the human-vector contact. Despite the considerable progress made in recent years, an effective vaccine against the virus is not yet available. The development of a dengue vaccine has been hampered by many unique challenges, including the need to ensure the absence of vaccine-induced enhanced severity of disease. Recombinant protein subunit vaccines offer a safer alternative to other vaccine approaches. Several subunit vaccine candidates are presently under development, based on different structural and non-structural proteins of the virus. Novel adjuvants or immunopotentiating strategies are also being tested to improve their immunogenicity. This review summarizes the current status and development trends of subunit dengue vaccines. PMID:26982462

  4. MFR-vaccination og autisme - et populationsbaseret followupstudie

    DEFF Research Database (Denmark)

    Madsen, Kreesten Meldgaard; Hviid, Anders; Vestergaard, Mogens;

    2002-01-01

    Summary: Summary A population-based study of measles, mumps, and rubella vaccination and autism. Ugeskr Læger 2002; 164: 5741-4. Introduction: It has been suggested that the measles-mumps-rubella (MMR) vaccination causes autism. Material and methods: We conducted a retrospective cohort study of all...... confidence interval, 0.65 to 1.07). There was no association between age at vaccination, time since vaccination or calendar period at time of vaccination and development of autistic disorder. Discussion: This study provides strong evidence against the hypothesis that MMR vaccination causes autism....... children born in Denmark from January 1991 through December 1998. The cohort was established based on data from the Danish Civil Registration System. A unique person identifiable number given to all subjects enabled linkage with other national registries. MMR vaccination status was obtained from the Danish...

  5. Dengue vaccine: an update on recombinant subunit strategies.

    Science.gov (United States)

    Martin, J; Hermida, L

    2016-03-01

    Dengue is an increasing public health problem worldwide, with the four serotypes of the virus infecting over 390 million people annually. There is no specific treatment or antiviral drug for dengue, and prevention is largely limited to controlling the mosquito vectors or disrupting the human-vector contact. Despite the considerable progress made in recent years, an effective vaccine against the virus is not yet available. The development of a dengue vaccine has been hampered by many unique challenges, including the need to ensure the absence of vaccine-induced enhanced severity of disease. Recombinant protein subunit vaccines offer a safer alternative to other vaccine approaches. Several subunit vaccine candidates are presently under development, based on different structural and non-structural proteins of the virus. Novel adjuvants or immunopotentiating strategies are also being tested to improve their immunogenicity. This review summarizes the current status and development trends of subunit dengue vaccines.

  6. Association between Chronic Arsenic Exposure and Nutritional Status among the Women of Child Bearing Age: A Case-Control Study in Bangladesh

    Directory of Open Access Journals (Sweden)

    Abul H. Milton

    2010-07-01

    Full Text Available The role of nutritional factors in arsenic metabolism and toxicity is yet to be fully elucidated. A low protein diet results in decreased excretion of DMA and increased tissue retention of arsenic in experimental studies. Malnourished women carry a higher risk of adverse pregnancy outcomes. Chronic exposure to high arsenic (>50 µg/L through drinking water also increases the risk of adverse pregnancy outcomes. The synergistic effects (if any of malnutrition and chronic arsenic exposure may worsen the adverse pregnancy outcomes. This population based case control study reports the association between chronic arsenic exposure and nutritional status among the rural women in Bangladesh. 348 cases (BMI < 18.5 and 360 controls (BMI 18.5–24.99 were recruited from a baseline survey conducted among 2,341 women. An excess risk for malnutrition was observed among the participants chronically exposed to higher concentrations of arsenic in drinking water after adjusting for potential confounders such as participant’s age, religion, education, monthly household income and history of oral contraceptive pills. Women exposed to arsenic >50 µg/L were at 1.9 times (Odds Ratio = 1.9, 95% CI = 1.1–3.6 increased risk of malnutrition compared to unexposed. The findings of this study suggest that chronic arsenic exposure is likely to contribute to poor nutritional status among women of 20–45 years.

  7. 深圳市宝安区托幼机构人员甲型H1N1流感疫苗接种率及其影响因素%Vaccination Coverage of Influenza A (H1N1) and the Influential Factors Among Child-care Staff in Bao'an District of Shenzhen City

    Institute of Scientific and Technical Information of China (English)

    周海庄; 李苑; 刘开钳; 吴泰顺; 马智超

    2012-01-01

    Objective To understand the vaccination coverage of influenza A (H1N1) and the its influential factors among child - care staff in Bao'an district of Shenzhen. Methods A survey of random sampling was carried out for 530 health - care workers from 100 kindergartens with anonymous questionnaire. Descriptive statistical analysis, Rank sum test, x2 test and Logistic regression analysis were used for univariate analysis and multiva-riate analysis to evaluate influential factors of vaccine coverage. Results The vaccination coverage rate of influenza A ( H1N1 ) in child - care staff in Bao'an district of Shenzhen was 39. 96%% , the main reason for un - inoculation was concerning about side effects. The multivariate analysis showed that the sex [ male, odds ratio (OR) = 3.193, 95% confidence interval (CI) - 1. 285 - 7. 936 ] , being sanitarian and nursery governess (sanitarian, OR = 12.583, 95% CI = 2.825 - 56.082; nursery governess, OR = 7.581, 95% CI = 1. 881 - 30. 554) , length of service (11 -15, OR =6. 299, 95% CI = 1. 169-33. 945) and with a seasonal influenza vaccination in the past three years (vaccinated, OR =8. 856, 95% CI =4. 139 - 18. 703; obscurity, OR = 4. 322, 95% CI = 1. 588 - 11. 766) were correlated with influenza A ( H1N1) vaccination (P < 0. 05 ). Conclusion The child - care staff in Bao'an had high vaccination coverage of influenza A ( H1N1). It is important to strengthen the propaganda of the effectiveness and security of influenza A (H1N1) vaccine, especially to women, being teacher, people who have length of service less than five years and without the history of seasonal influenza vaccination in the past three years.%目的 了解深圳市宝安区托幼机构人员甲型H1N1流行性感冒(甲流)疫苗接种率及其影响因素.方法 随机抽取深圳市宝安区100家托幼机构530人作为面访匿名问卷调查对象.采用描述性分析、秩和检验、x 2检验和Logistic回归分析分别对疫苗接种率的影响因素进行单

  8. [Influence of genetic and phenotypical factors on the efficiency of the vaccination of young children against diphtheria and measles].

    Science.gov (United States)

    Gordeeva, L A; Shabaldin, A V; Semenova, E M; Glushkov, A N

    2006-01-01

    The child's sex was shown to influence the character of antibody formation only after immunization against diphtheria with live measles vaccine: girls exhibited stronger reaction to vaccination than boys. Children of different gender were found to have characteristic HLA DR markers of humoral immune response to diphtheria toxoid and measles vaccine. HLA DR7 proved to be the marker of low production of antibodies to diphtheria toxoid and measles vaccine in boys.

  9. Diphtheria-tetanus-pertussis vaccination administered after measles vaccine: increased female mortality?

    Science.gov (United States)

    Benn, Christine Stabell; Aaby, Peter

    2012-10-01

    In low-income countries, children should receive 3 doses of diphtheria-tetanus-pertussis vaccine (DTP) at 6, 10 and 14 weeks of age, and measles vaccine at 9 months of age. However, there is often a delay in administering the vaccines, and DTP is often given after measles vaccine. Previous observations suggest that this practice is associated with increased mortality for female, but not for male children. Within a vitamin A trial in Guinea-Bissau, vaccination status was registered at the time of measles vaccination at 9 months; 141 (31%) of 455 children were missing 1 or more DTP vaccines and were likely to receive them afterward. We examined whether missing DTP vaccine at this time point was associated with sex-differential effects on mortality. In female children, missing DTP was associated with 3.55 (95% confidence interval: 1.23-10.26) times higher risk of dying before 36 months of age, whereas it made no difference in male children (0.97 [0.34-2.80]). The result supports that receiving DTP after measles vaccine affects female children negatively.

  10. Understanding Child Rights in India

    Science.gov (United States)

    Grewal, Imandeep Kaur; Singh, Nandita Shukla

    2011-01-01

    Research Findings: This article traces the status of child rights in India, with special attention to traditional beliefs that have shaped and sustain gender discrimination. The article examines the possibilities and limitations of the newly implemented Right of Children to Free and Compulsory Education Act of 2009 for operating as an equalizing…

  11. Disobedient Child

    Science.gov (United States)

    ... of their parents' rules and of their own self-control. Sometimes, however, these conflicts are more than occasional ... a timeout until he calms down and regains self-control. When your child is obedient and respectful, compliment ...

  12. Trends in childhood vaccine purchase costs in the US public sector: 1996-2014.

    Science.gov (United States)

    Chen, Weiwei; Messonnier, Mark; Zhou, Fangjun

    2016-09-01

    While vaccination remains as one of the most cost-effective preventive strategies, the cost of fully immunizing a child has grown considerably over the last few decades. This study examines trends in non-influenza childhood vaccine purchase costs in the public sector from 1996 to 2014. Non-influenza vaccine purchase cost per child for children aged 0 through 18years was calculated based on public-sector purchase prices. Purchase cost changes were then decomposed into changes attributable to recommendation updates and changes attributable to price variation. The study analyzed the growth rate of combination vaccine prices separately and compared these prices with the sum of prices of component vaccines. It is found that the average annual growth rate of non-influenza vaccine purchase cost per child during 1996-2014 was 12.6%. The growth rate attributable to price changes was 1.0% on average. Combination vaccine prices showed greater variation. The study concludes that vaccine price variation was one but a minor reason for purchase cost changes. Recommendation updates, particularly the introduction of new vaccines, played a much larger role in raising the purchase costs. If the 12.6% annual growth rate found during 1996-2014 in the study continues to apply, the purchase costs of childhood vaccines may more than double by 2020. PMID:27522176

  13. A Dengue Vaccination Model for Immigrants in a Two-Age-Class Population

    Directory of Open Access Journals (Sweden)

    Hengki Tasman

    2012-01-01

    Full Text Available We develop a model of dengue transmission with some vaccination programs for immigrants. We classify the host population into child and adult classes, in regards to age structure, and into susceptible, infected and recovered compartments, in regards to disease status. Since migration plays important role in disease transmission, we include immigration and emigration factors into the model which are distributed in each compartment. Meanwhile, the vector population is divided into susceptible, exposed, and infectious compartments. In the case when there is no incoming infected immigrant, we obtain the basic reproduction ratio as a threshold parameter for existence and stability of disease-free and endemic equilibria. Meanwhile, in the case when there are some incoming infected immigrants, we obtain only endemic equilibrium. This indicates that screening for the immigrants is important to ensure the effectiveness of the disease control.

  14. Child's right to special care.

    Science.gov (United States)

    Sharma, A; Gupta, S

    1991-01-01

    In 1924, the League of Nations adopted the 1st international law recognizing that children have inalienable rights and are not the property of their father. The UN Declaration on the Rights of the Child emerged in 1959. 1979 was the International Year of the Child. In 1990 there was the World Summit on Children and the UN General Assembly adopted the Global Convention on the Rights of the Child. The convention included civil, economic, social, cultural, and political rights of children all of which covered survival, development, protection, and participation. At the end of 1990, 60 countries had ratified the convention, thus including it into their national legislation. Even though India had not yet endorsed the Convention by the end of 1991, it expressed its support during the 1st workshop on the Rights of the Child which focused on girls. India has a history of supporting children as evidenced by 250 central and state laws on their welfare such as child labor and child marriage laws. In 1974, India adopted the National Policy for Children followed by the establishment of the National Children's Board in 1975. The Board's activities resulted in the Integrated Child Development Services Program which continues to include nutrition, immunization, health care, preschool education, maternal education, family planning, and referral services. Despite these laws and actions, however, the Indian government has not been able to improve the status of children. For example, between 1947-88, infant mortality fell only from 100/1000 to 93/1000 live births and child mortality remained high at 33.3 in 1988 compared with 51.9 in 1971. Population growth poses the biggest problem to improving their welfare. Poverty also exacerbates their already low status. PMID:12317284

  15. [Anti-pneumococcal vaccine coverage for hospitalized risk patients: Assessment and suggestions for improvements].

    Science.gov (United States)

    Richard, C; Le Garlantezec, P; Lamand, V; Rasamijao, V; Rapp, C

    2016-05-01

    Streptococcus pneumoniae can cause invasive infections. Incidence and severity are linked to patients' risk factors. Due to the resistance to leading antibiotics, the anti-pneumococcal vaccination has become a major public health issue. The purpose of this survey was to evaluate the anti-pneumococcal vaccine coverage in a population of adults with risk factors. This was a prospective study that included patients with at least one recommendation for pneumococcal vaccination as indicated by the Weekly Epidemiological Bulletin (BEH), to which three further US recommendations were added (diabetes, obesity and age>65years). One hundred and thirty-four patients with an average age of 70 years were included. The physician could only confirm 68 % of the patients' vaccination status. Vaccination coverage as recommended by the BEH board was 30 % (n=54). All HIV patients were vaccinated (n=2) and the vaccination coverage was 75 % (n=8) for patients treated for autoimmune diseases and only 10 % (n=20) for patients treated with chemotherapy. Patients with no vaccination didn't know the existence of the vaccine or didn't know that vaccination was recommended to them. This study has highlighted a deficit in pneumococcal vaccination coverage and a high level of ignorance of the existence of recommended vaccination. In addition to awareness campaign for patients and caregiver training, the expansion of the vaccine e-book utilization could improve the vaccination status. PMID:26619926

  16. Requiring human papillomavirus vaccine for immigrant women.

    Science.gov (United States)

    Hachey, Krista J; Allen, Rebecca H; Nothnagle, Melissa; Boardman, Lori A

    2009-11-01

    The Centers for Disease Control and Prevention Advisory Committee on Immunization Practices recommends human papillomavirus (HPV) vaccination of 11- to 12-year-old girls, with catch-up vaccination for girls and women aged 13 to 26 years. Although compulsory HPV vaccination is not currently mandated for any U.S. population, immigrant women aged 11-26 years are now required to receive the first injection of the vaccine (the full series consists of three doses) as a result of the 1996 Illegal Immigration Reform and Immigrant Responsibility Act. According to this law, immigrants applying for visas to enter the United States or to adjust their immigration status must receive the inoculations that the Advisory Committee on Immunization Practices recommends for U.S. residents. In the case of HPV, this law represents not only an undue burden on immigrant women, but also raises scientific and ethical questions regarding the benefit of vaccination in this population. Given these issues, immigrant women should not be required to provide documentation of HPV vaccination at the time of visa application or adjustment of immigration status. PMID:20168117

  17. BCG vaccination: a role for vitamin D?

    Directory of Open Access Journals (Sweden)

    Maeve K Lalor

    Full Text Available BACKGROUND: BCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis. This study objective was to determine if there was an association between circulating 25(OHD concentrations and BCG vaccination status and cytokine responses following BCG vaccination in infants. METHODS: Blood samples were collected from UK infants who were vaccinated with BCG at 3 (n = 47 and 12 (n = 37 months post BCG vaccination. These two time-points are denoted as time-point 1 and time-point 2. Two blood samples were also collected from age-matched unvaccinated infants (n = 32 and 28 respectively, as a control group. Plasma vitamin D concentrations (25(OHD were measured by radio-immunoassay. The cytokine IFNγ was measured in supernatants from diluted whole blood stimulated with M.tuberculosis (M.tb PPD for 6 days. RESULTS: 58% of infants had some level of hypovitaminosis (25(OHD <30 ng/ml at time-point 1, and this increased to 97% 9 months later. BCG vaccinated infants were almost 6 times (CI: 1.8-18.6 more likely to have sufficient vitamin D concentrations than unvaccinated infants at time-point 1, and the association remained strong after controlling for season of blood collection, ethnic group and sex. Among vaccinees, there was also a strong inverse association between IFNγ response to M.tb PPD and vitamin D concentration, with infants with higher vitamin D concentrations having lower IFNγ responses. CONCLUSIONS: Vitamin D may play an immuno-regulatory role following BCG vaccination. The increased vitamin D concentrations in BCG vaccinated infants could have important implications: vitamin D may play a role in immunity induced by BCG vaccination and may contribute to non-specific effects observed following BCG vaccination.

  18. Factors determining whether the parents accept BCG immunization of the new-born child in a high-income country

    DEFF Research Database (Denmark)

    Thybo Pihl, Gitte; Ammentorp, Jette; Kofoed, Poul-Erik

    Introduction: A large prospective randomised clinical trial in Denmark is planned to test the hypothesis that compared to non-BCG-vaccinated infants, infants who are BCG vaccinated at birth experience less hospitalisations, use less antibiotics, and develop less atopic disease in early childhood......' Connors 'Decisional Conflict scale' to compare decisional conflicts for the parents that accept BCG vaccination and parents who do not accept the BCG vaccination of their newborn child....

  19. Freqüência à creche e outros condicionantes do estado nutricional infantil Attendance at day-care centers and other conditioning factors in child nutritional status

    Directory of Open Access Journals (Sweden)

    Marina Vieira da Silva

    1998-06-01

    Full Text Available O estudo descreve o estado nutricional de 2 096 pré-escolares atendidos nos 27 Centros Educacionais e Creches do município de Piracicaba, estado de São Paulo. Observa-se que 5,1% das crianças apresentam déficit de altura/idade (escore ZAI The study describes the nutritional status of 2 096 preschool children attending 27 Educational Centers and Day-Care Centers in Piracicaba, state of São Paulo. Five point one percent of the children are observed to present a height/age deficit (score HAZ<-2.0 and a proportion of 1.2 with weight/height deficit (score WHZ<-2.0. The results reveal that per capita income, mother schooling, type of sewage, type of housing and attendance time at are the variables that cause impact on the HAZ score of the children.The positive association detected between attendance time at and -Z score of height for age stresses the importance of these investments as means to protect children, mainly against chronic malnutrition, as basic care with health, feeding and hygiene is associated with education. The day-care center also provides the participation of mothers in the work market, which is very important in poor families in order to increase family income.

  20. Mucosal vaccination of fish

    NARCIS (Netherlands)

    Rombout, J.H.W.M.; Kiron, V.

    2014-01-01

    Among the novel vaccination methods, mucosal vaccination seems to possess all the desired criteria. The chapter reviews the state-of-the-art knowledge regarding this type of vaccination with a focus on their uptake, immune stimulation, and where possible, discusses their potential as future vaccines

  1. History of vaccination

    OpenAIRE

    Plotkin, Stanley

    2014-01-01

    Vaccines have a history that started late in the 18th century. From the late 19th century, vaccines could be developed in the laboratory. However, in the 20th century, it became possible to develop vaccines based on immunologic markers. In the 21st century, molecular biology permits vaccine development that was not possible before.

  2. Anthrax vaccine as a component of the strategic national stockpile: a dilemma for Homeland Security

    OpenAIRE

    Rempfer, Thomas L.

    2009-01-01

    CHDS State/Local The author explains how past problems with the Defense Department anthrax vaccine currently affect Department of Homeland Security and Department of Health and Human Services policy. The departments included the BioThrax® anthrax vaccine in the Strategic National Stockpile following the 2001 anthrax letter attacks. According to the Federal Bureau of Investigation, the vaccine's "failing" status possibly motivated the letter attacks to create demand for the vaccine. This ...

  3. The association of parents, family status and build a harmonious parent-child relationship%父母的家庭地位与构建和谐亲子关系的关联探究

    Institute of Scientific and Technical Information of China (English)

    李无言

    2013-01-01

      在中国,家庭是个绵延性的事业社群,中国的家庭通过血缘以及姻亲关系而紧密的团结在一起,并且通过不断地血缘延展和开拓姻亲关系使自身不断地壮大。同时,在家庭的内部通过不同身份的家庭成员之间的依据其自身承担的角色而进行互动来把家庭进一步延续下去。在中国,这种角色之间责任的互动适用的主体是父母与子女这两代人,而隐藏在这种责任背后的是父母,子女之间家庭地位之间的的碰撞,因而父母与子女之间家庭地位之间的关系成为研究中国家庭关系的重要方面,这是因为中国的家庭“它的主轴是在父子之间,在婆媳之间,是纵的,不是横的。夫妻成了配轴”,于是父母的权威地位与构建和谐亲子关系之间便建立了联系。%In China, the family is the cause of community stretches of China's family by blood and affinity and close together, and through blood continuously extend and develop affinity make themselves continue to grow. Meanwhile, in the family's internal identity through different between family members based on their own commitment to the role and interaction of the family to further continue. In China, this kind of interaction between roles responsibilities for the main body of these two generations of parents and children, while hidden behind this responsibility of parents, children, family status between the collision between, so the parents and children the relationship between family status of China as an important aspect of family relationships, it is because China's Family"it is in the spindle between father and son in-law, and is the vertical, not horizontal. couple became with shaft", so parental authority status and build a harmonious parent-child relationship is established between the contact.

  4. Progress in developing an infant and child feeding index

    OpenAIRE

    Arimond, Mary; Ruel, Marie T.

    2002-01-01

    "Feeding practices are an important determinant of the nutritional status of infants and children. It is therefore useful to measure and describe infant and child feeding practices in a number of contexts. Such measurements could enable (1) international comparisons of the adequacy of infant and child feeding, (2) research linking infant and child feeding to determinants or outcomes, (3) advocacy regarding the importance of adequate infant and child feeding, and (4) monitoring and evaluation ...

  5. A Study of the Cycle of Abuse among Child Molesters.

    Science.gov (United States)

    Coxe, Ray; Holmes, William

    2001-01-01

    This study of 147 sex offenders on probation explores whether there is support for the cycle of abuse theory among child molesters. Results indicate that being abused as a child is related to being a child molester. It was also found that the MMPI-2 did not predict the status of the subjects in regard to being abused as a child and having a victim…

  6. Nonstandard Work and Child Care Choices of Married Mothers

    OpenAIRE

    Jean Kimmel; Lisa Powell

    2006-01-01

    The focus of this paper is to examine the interplay between nonstandard employment (i.e., shift work) and child care choice decisions of married mothers with young children. We contribute to the child care choice literature by examining the impact of nonstandard work on the child care choice decisions of mothers taking into account the likely endogeneity of nonstandard work. Also, we examine the extent to which child care prices simultaneously affect work status (no work versus standard work ...

  7. Yellow fever vaccine: worthy friend or stealthy foe?

    Science.gov (United States)

    Seligman, Stephen J; Casanova, Jean-Laurent

    2016-06-01

    Recognition that the live yellow fever vaccine may rarely be associated with viscerotropic disease (YEL-AVD) has diminished its safety status. However, the vaccine remains the principal tool for limiting the occurrence of yellow fever, making large portions of Africa and South America more habitable. The subject has previously been exhaustively reviewed. Novel concepts in the current report include the description of a systematic method for deciding whom to vaccinate, recommendations for obtaining data helpful in making that decision, and suggestions for additional study. The vaccine is indeed a worthy friend, but its adverse reactions need to be recognized. PMID:27087465

  8. Influenza vaccination coverage in children with inflammatory bowel disease

    OpenAIRE

    Banaszkiewicz, Aleksandra; Klincewicz, Beata; Łazowska-Przeorek, Izabella; Grzybowska-Chlebowczyk, Urszula; Kąkol, Paulina; Mytyk, Aleksandra; Kofla, Anna; Radzikowski, Andrzej

    2014-01-01

    The aim of this study was to evaluate the influenza vaccination status among paediatric patients with inflammatory bowel disease (IBD) in Poland. This was a questionnaire-based study. 242 patients with IBD and 142 controls were enrolled in the study. Of patients with IBD, 7·8% received an influenza vaccine, compared to 18·3% of controls (P = 0·0013). There were no statistically significant differences in time from IBD diagnosis, disease activity and in drugs, between vaccinated and non-vaccin...

  9. Yellow fever vaccine: worthy friend or stealthy foe?

    Science.gov (United States)

    Seligman, Stephen J; Casanova, Jean-Laurent

    2016-06-01

    Recognition that the live yellow fever vaccine may rarely be associated with viscerotropic disease (YEL-AVD) has diminished its safety status. However, the vaccine remains the principal tool for limiting the occurrence of yellow fever, making large portions of Africa and South America more habitable. The subject has previously been exhaustively reviewed. Novel concepts in the current report include the description of a systematic method for deciding whom to vaccinate, recommendations for obtaining data helpful in making that decision, and suggestions for additional study. The vaccine is indeed a worthy friend, but its adverse reactions need to be recognized.

  10. Vaccine adverse events.

    Science.gov (United States)

    Follows, Jill

    2012-01-01

    Millions of adults are vaccinated annually against the seasonal influenza virus. An undetermined number of individuals will develop adverse events to the influenza vaccination. Those who suffer substantiated vaccine injuries, disabilities, and aggravated conditions may file a timely, no-fault and no-cost petition for financial compensation under the National Vaccine Act in the Vaccine Court. The elements of a successful vaccine injury claim are described in the context of a claim showing the seasonal influenza vaccination was the cause of Guillain-Barré syndrome.

  11. Nucleic Acid Vaccines

    Institute of Scientific and Technical Information of China (English)

    LU Shan

    2004-01-01

    @@ Anew method of immunization was discovered in the early 1990s. Several research groups independently demonstrated that direct inoculation of DNA plasmids coding for a specific protein antigen could elicit immune responses against that antigen[1-4].Since in theory the mRNA molecules also have the potential to be translated into the protein antigen, this vaccination approach was officially named by WHO as the nucleic acid vaccination even though the term DNA vaccine has been used more commonly in the literature. This novel approach is considered the fourth generation of vaccines after live attenuated vaccines, killed or inactivated vaccines and recombinant protein based subunit vaccines.

  12. Child Computer Interaction SIG

    DEFF Research Database (Denmark)

    Read, Janet; Hourcade, Juan Pablo; Markopoulos, Panos;

    The discipline of Child Computer Interaction (CCI) has been steadily growing and it is now firmly established as a community in its own right, having the annual IDC (Interaction and Design for Children) conference and its own journal and also enjoying its role as a highly recognisable and vibrant...... contributor to the ACM CHI conference. Having recently been given status as an IFIP (International Federation for Information Processing) TC13 working group, the community now needs to make plans around its academic themes and its coherence as a developing academic community. The CCI SIG at CHI aims to use...

  13. ADVERSE EVENTS POST-DTAP AND DTwP VACCINATION IN THAI CHILDREN.

    Science.gov (United States)

    Fortuna, Librada; Sirivichayakul, Chukiat; Watanaveeradej, Veerachai; Soonthornworasiri, Ngamphol; Sitcharungsi, Raweerat

    2015-07-01

    We conducted a prospective study to compare the development of fever (axillary T ≥ 37.9 °C) within 4 hours of vaccination, determine the proportion of children who develop high fever (T ≥ 39°C) and evaluate parental days missed from work due to their children's vaccination with either the diphtheria-tetanus-whole cell pertussis (DTwP) or diphtheria-tetanus-acellular pertussis (DTaP) vaccine. The results of this study can help physicians and parents decide whether to have their child vaccinated with the DTwP or more expensive DTaP vaccine. We studied 140 healthy Thai children aged 2 months to 6 years from December 2011 to March 2012 who presented for vaccination. Parents recorded their child's temperature, local and systemic adverse reactions and missed days from work due to these adverse events on a diary card. Of the 140 participants, 72 received the DTwP vaccine and 68 received the DTaP vaccine. The median (IQR) age was 4 (2-6) months and the median weight was 7.1 (5.6-8.7) kg. Twenty children developed fever (axillary T ≥ 37.9°C) within 4 hours following vaccination, 17 (23.6%) had received the DTwP vaccine and 3 (4.4%) had received the DTaP vaccine (p = 0.040). One child (1.4%) who had received the DTwP vaccine and none who received the DTaP vaccine developed high fever (T ≥ 39°C) within 4 hours of vaccination (p = 0.329). Parents of two children who received the DTwP vaccine and one child who received the DTaP vaccine missed work following vaccination (p = 0.059). In conclusion, children who received the DTwP vaccines were more likely to have early post-vaccination fever and higher fever but there was no significant difference between the two groups in parental days lost from work.

  14. Smallpox vaccines: targets of protective immunity.

    Science.gov (United States)

    Moss, Bernard

    2011-01-01

    The eradication of smallpox, one of the great triumphs of medicine, was accomplished through the prophylactic administration of live vaccinia virus, a comparatively benign relative of variola virus, the causative agent of smallpox. Nevertheless, recent fears that variola virus may be used as a biological weapon together with the present susceptibility of unimmunized populations have spurred the development of new-generation vaccines that are safer than the original and can be produced by modern methods. Predicting the efficacy of such vaccines in the absence of human smallpox, however, depends on understanding the correlates of protection. This review outlines the biology of poxviruses with particular relevance to vaccine development, describes protein targets of humoral and cellular immunity, compares animal models of orthopoxvirus disease with human smallpox, and considers the status of second- and third-generation smallpox vaccines.

  15. Effectiveness of Vi capsular polysaccharide typhoid vaccine among children: a cluster randomized trial in Karachi, Pakistan

    NARCIS (Netherlands)

    Khan, M.I.; Soofi, S.B.; Ochiai, R.L.; Habib, M.A.; Sahito, S.M.; Nizami, S.Q.; Acosta, C.J.; Clemens, J.D.; Bhutta, Z.A.; Group, D.T.K.V.E.S.

    2012-01-01

    BACKGROUND: Typhoid fever is endemic in Karachi, with an incidence among children ranging from 170 to 450 per 100,000 child-years. Vaccination strategies are important for prevention, and the Vi capsular polysaccharide (ViCPS) vaccine has been shown to be effective in reducing the burden of typhoid

  16. Vaccine-Related Beliefs and Practices of Parents of Children with Autism Spectrum Disorders

    Science.gov (United States)

    Bazzano, Alicia; Zeldin, Ari; Schuster, Erica; Barrett, Christopher; Lehrer, Danise

    2012-01-01

    Although the assertion of a link between vaccines and autism has been scientifically rejected, the theory continues to be popular and may influence the attitudes of parents of children with autism spectrum disorders. The authors sought to assess how often parents change or discontinue their child's vaccine schedule after autism spectrum disorder…

  17. Retinopathy following measles, mumps, and rubella vaccination in an immuno-incompetent girl

    NARCIS (Netherlands)

    Schuil, J.; van de Putte, E.M.; Zwaan, C.M.; Koole, F.D.; Meire, F.M.

    1998-01-01

    We describe a 4-year-old girl with subnormal visual acuity due to a bilateral retinopathy. The child had a history of encephalitis following MMR vaccination. Temporary retinopathy associated with measles, mumps, and rubella (MMR) vaccination has been described. Recently an idiopathic CD4+ T lymphocy

  18. BCG vaccination scar associated with better childhood survival in Guinea-Bissau

    DEFF Research Database (Denmark)

    Roth, Adam Anders Edvin; Gustafson, Per; Nhaga, Alexandro;

    2005-01-01

    Recent studies have suggested that Bacille Calmette-Guerin (BCG) vaccination may have a non-specific beneficial effect on infant survival and that a BCG scar may be associated with lower child mortality. No study has previously examined the influence of BCG vaccination on cause of death....

  19. Malaria vaccine: a current perspective

    Directory of Open Access Journals (Sweden)

    Shobhona Sharma

    2008-02-01

    Full Text Available The observation that inactivated Plasmodium sporozoites could protect against malaria is about a hundred years old. However, systematic demonstration of protection using irradiated sporozoites occurred in the nineteen-sixties, providing the impetus for the development of a malaria vaccine. In 1983, the circumsporozoite protein (CSP, a major sporozoite surface antigen, became the first Plasmodium gene to be cloned, and a CSP-based vaccine appeared imminent. Today, 25 years later, we are still without an effective malaria vaccine, despite considerable information regarding the genomics and proteomics of the malaria parasites. Although clinical immunity to malaria has been well-documented in adults living in malaria endemic areas, our understanding of the host-immune responses operating in such malaria immune persons remains poor, and limits the development of immune control of the disease. Currently, several antigen and adjuvant combinations have entered clinical trials, in which efficacy against experimental sporozoite challenge and/or exposure to natural infection is evaluated. This review collates information on the recent status of the field. Unresolved challenges facing the development of a malaria vaccine are also discussed.

  20. Attitudes toward vaccination and the H1N1 vaccine: poor people's unfounded fears or legitimate concerns of the elite?

    Science.gov (United States)

    Peretti-Watel, Patrick; Raude, Jocelyn; Sagaon-Teyssier, Luis; Constant, Aymery; Verger, Pierre; Beck, François

    2014-05-01

    In 2009-2010, the H1N1 episode occurred in a general context of decreasing public confidence in vaccination. We assumed opposition to vaccination in general to be an 'unfounded fear', reflecting ignorance and perceived vulnerability among low-socioeconomic status (SES) people, and opposition to the H1N1 vaccine a 'legitimate concern' reflecting the elite's commitment to 'risk culture' in a 'risk society'. We indirectly tested these assumptions by investigating the socioeconomic profiles associated with opposition to vaccination in general and opposition to the H1N1 vaccine specifically. Our second aim was to determine whether or not opposition to the H1N1 vaccine fuelled opposition to vaccination in general. We used data from a telephone survey conducted in 2009-2010 among a random sample of French people aged 15-79 (N = 9480). Attitudes toward vaccination in general and toward the H1N1 vaccine specifically varied significantly between October 2009 and June 2010 with strong correlation being observed between these attitudes throughout the whole period. In multivariable analysis attitudes toward vaccination in general remained a significant predictor of attitudes to the H1N1 vaccine and vice versa, for distinct profiles as follows: males, older people, low-SES people for opposition to vaccination in general, versus females, people aged 35-49 and those with an intermediate SES for opposition to the H1N1 vaccine. Results also differed regarding indicators of social vulnerability, proximity to preventive medicine and vaccination history. The first profile supported the "unfounded fears expressed by low-SES people" hypothesis, while the second echoed previous work related to middle-classes' "healthism". Opposition to vaccination should not be reduced to irrational reactions reflecting ignorance or misinformation and further research is needed to acquire a greater understanding of the motives of opponents.

  1. The Prevention of Liver Cancer by HBV Vaccine Program

    Institute of Scientific and Technical Information of China (English)

    TAO Xiong

    2002-01-01

    Objective To recognize the HBV vaccine program for prevention of the hepatic cancer.Methods To discuss the relation between the HBV and hepatic cancer arising, and to discuss the immunology respond of the HBV vaccine (HBV surface antigen protein) in our patient group. Result Our data indicates that the predisposing of the HBV infection is required for the hepatic cancer arising and for the high expression of the AFP gene, and our data indicates that the HBV vaccine can induce highly immuno respond in about 78.8 % of the adult for achieving the HBV prevention status and the hepatic cancer prevention status.

  2. Oral vaccination of fish

    OpenAIRE

    Embregts, Carmen W.E.; Forlenza, Maria

    2016-01-01

    The limited number of oral vaccines currently approved for use in humans and veterinary species clearly illustrates that development of efficacious and safe oral vaccines has been a challenge not only for fish immunologists. The insufficient efficacy of oral vaccines is partly due to antigen breakdown in the harsh gastric environment, but also to the high tolerogenic gut environment and to inadequate vaccine design. In this review we discuss current approaches used to develop oral vaccines fo...

  3. Towards universal influenza vaccines?

    OpenAIRE

    Osterhaus, Ab; Fouchier, Ron; Rimmelzwaan, Guus

    2011-01-01

    Vaccination is the most cost-effective way to reduce the considerable disease burden of seasonal influenza. Although seasonal influenza vaccines are effective, their performance in the elderly and immunocompromised individuals would benefit from improvement. Major problems related to the development and production of pandemic influenza vaccines are response time and production capacity as well as vaccine efficacy and safety. Several improvements can be envisaged. Vaccine production technologi...

  4. Vaccines against poverty

    OpenAIRE

    MacLennan, Calman A.; Saul, Allan

    2014-01-01

    With the 2010s declared the Decade of Vaccines, and Millennium Development Goals 4 and 5 focused on reducing diseases that are potentially vaccine preventable, now is an exciting time for vaccines against poverty, that is, vaccines against diseases that disproportionately affect low- and middle-income countries (LMICs). The Global Burden of Disease Study 2010 has helped better understand which vaccines are most needed. In 2012, US$1.3 billion was spent on research and development for new vacc...

  5. Reaching more children with vaccines in developing countries: key challenges of innovation and delivery.

    Science.gov (United States)

    Popova, Olga; Ibarra de Palacios, Patricia

    2016-01-01

    As we reach the deadline for the United Nations fourth Millennium Development Goal to reduce child mortality, many inequalities in vaccine access still exist, particularly for children in developing countries. Here we discuss some of the barriers to vaccine access in these countries, as well as some of the innovative approaches that could address these. Finally, we discuss the need to create a global environment conducive to innovation directed at low-resource settings, aimed to ultimately increase vaccine coverage.

  6. Factors associated with seasonal influenza vaccine uptake among children in Japan

    OpenAIRE

    Shono, Aiko; Kondo, Masahide

    2015-01-01

    BackgroundSeasonal influenza vaccine was once part of the routine immunization schedule that is routinely offered to all children in Japan, but it is now excluded from the schedule. This study aimed to investigate factors influential to parents’ decision to have their children receive seasonal influenza vaccine, as well as types of seasonal influenza vaccine information that is given to parents.MethodsWe conducted a cross-sectional online survey of 555 participants who have at least one child...

  7. Local public health response to vaccine-associated measles: case report

    OpenAIRE

    Hau, Monica; Schwartz, Kevin L; Frenette, Crystal; Mogck, Isabelle; Jonathan B Gubbay; Severini, Alberto; Hiebert, Joanne; Shelley L Deeks; Shaun K Morris

    2013-01-01

    Background The most appropriate public health approach to vaccine-associated measles in immunocompromised patients is unknown, mainly because these cases are rare and transmission of vaccine-associated measles has not been previously documented. In this case report, we describe Peel Public Health’s response to a vaccine-associated measles case in an immunocompromised child in Ontario, Canada. Case presentation A five-year-old Canadian-born boy with a history of a hematopoetic stem cell transp...

  8. Valuable Work, Minimal Rewards: A Report on the Wisconsin Child Care Work Force.

    Science.gov (United States)

    Burton, Alice; And Others

    A 1994 state-wide survey examined the status of child care profession in Wisconsin. Surveyed were 326 family child care providers, 104 child care center directors, and 254 center teaching staff. Responses indicated that child care teaching staff have experienced a wage increase of just over 1 percent per year since 1988, and continue to earn low…

  9. Studies on the duration of immunity induced in cattle after natural FMD infection and post vaccination with bivalent oil vaccine

    Directory of Open Access Journals (Sweden)

    Ehab El-Sayed

    Full Text Available Aim: To detect the proper time for vaccination of infected calves after the onset of clinical signs and revaccination for previously vaccinated animals with bivalent FMD montanide ISA206 inactivated vaccine. Materials and Methods: Twenty calves naturally infected with foot and mouth disease (FMD showing clinical signs represented by lesions on the tongue, buccal mucosa and feet. Samples were collected from these calves including tongue epithelial and oropharyngeal fluid (OP. The causative virus was isolated from such samples through inoculation of baby mice and typed by indirect Sandwich ELISA and was confirmed in 2 tongue epithelia samples using PCR. Results: The serum antibody titers were determined using SNT and ELISA in the sera of the 20 infected calves revealing that the infected farms should be vaccinated with inactivated bivalent FMD vaccine for (type O and A Adjuvanted with montanide ISA206 after 32 weeks from the appearance of clinical signs. In addition the FMD immune status was monitored in 2 farms in EL-Fayoum and El-Sharkia Governorates where 50 calves in each farm were vaccinated with the bivalent FMD inactivated vaccine adjuvaned with montanide ISA206 and serum samples were collected monthly from these animals to determine their immune status using SNT and ELISA. The obtained results showed that vaccinated calves with the bivalent FMD montanide ISA206 inactivated vaccine should be revaccinated after 36 weeks post vaccination. Conclusions: naturally infected calves should be vaccinated on the 32 weeks post infection while vaccinated calves should be revaccinated on the 36 weeks post vaccination. [Vet World 2012; 5(10.000: 603-608

  10. Relationship between parent held child records for immunisations, parental recall and health service.

    LENUS (Irish Health Repository)

    Jessop, L

    2011-03-01

    Parent held child records (PHCR) were introduced in Ireland in 2008. This study investigated the relationship between the PHCR, parental recall and regional Health Service Executive (HSE) records for immunisation uptake. It used the Lifeways cohort study of 1070 singleton children to compare immunisation data from PHCR at one year, parental recall at five years and information from the HSE. When compared to HSE records, full recording of primary immunisations in the PHCR was reported for 695 of 749 (92.8%) children. Parental recall was correct for 520 of 538 (96.7%) children. Of the 307 completed PHCRs, 207 (75.9%) agreed with the HSE records. Agreement between the three sources for primary immunisations was 74-93% but was not statistically significant. Agreement was 91% (p < 0.001) for measles, mumps and rubella (MMR) vaccines between parental recall and HSE records. PHCRs underestimated and parental recall overestimated immunisation status when compared with HSE records.

  11. Barriers to pandemic influenza vaccination and uptake of seasonal influenza vaccine in the post-pandemic season in Germany

    Directory of Open Access Journals (Sweden)

    Böhmer Merle M

    2012-10-01

    Full Text Available Abstract Background In Germany, annual vaccination against seasonal influenza is recommended for certain target groups (e.g. persons aged ≥60 years, chronically ill persons, healthcare workers (HCW. In season 2009/10, vaccination against pandemic influenza A(H1N1pdm09, which was controversially discussed in the public, was recommended for the whole population. The objectives of this study were to assess vaccination coverage for seasonal (seasons 2008/09-2010/11 and pandemic influenza (season 2009/10, to identify predictors of and barriers to pandemic vaccine uptake and whether the controversial discussions on pandemic vaccination has had a negative impact on seasonal influenza vaccine uptake in Germany. Methods We analysed data from the ‘German Health Update’ (GEDA10 telephone survey (n=22,050 and a smaller GEDA10-follow-up survey (n=2,493, which were both representative of the general population aged ≥18 years living in Germany. Results Overall only 8.8% of the adult population in Germany received a vaccination against pandemic influenza. High socioeconomic status, having received a seasonal influenza shot in the previous season, and belonging to a target group for seasonal influenza vaccination were independently associated with the uptake of pandemic vaccines. The main reasons for not receiving a pandemic vaccination were ‘fear of side effects’ and the opinion that ‘vaccination was not necessary’. Seasonal influenza vaccine uptake in the pre-pandemic season 2008/09 was 52.8% among persons aged ≥60 years; 30.5% among HCW, and 43.3% among chronically ill persons. A decrease in vaccination coverage was observed across all target groups in the first post-pandemic season 2010/11 (50.6%, 25.8%, and 41.0% vaccination coverage, respectively. Conclusions Seasonal influenza vaccination coverage in Germany remains in all target groups below 75%, which is a declared goal of the European Union. Our results suggest that controversial

  12. Status of hepatitis B infection - a decade after hepatitis B vaccination of susceptible Nicobarese, an indigenous tribe of Andaman & Nicobar (A&N) islands with high hepatitis B endemicity

    OpenAIRE

    Bhattacharya, Haimanti; Bhattacharya, Debdutta; Ghosal, S.R.; Roy, Subarna; Sugunan, A. P.

    2015-01-01

    Background & objectives: Andaman and Nicobar Islands of India, home to six primitive tribes, constituting about 10 per cent of the total population of these Islands have been detected with high endemicity of hepatitis B infection. During 2000, a total of 936 individuals ≤ 45 yr, negative for hepatitis B surface antigen (HBsAg) and antibody anti-HBs were vaccinated with three doses of a recombinant DNA hepatitis B vaccine in two villages of Car Nicobar Islands. The present study was undertaken...

  13. Vaccine administration in children with chronic kidney disease.

    Science.gov (United States)

    Esposito, Susanna; Mastrolia, Maria Vincenza; Prada, Elisabetta; Pietrasanta, Carlo; Principi, Nicola

    2014-11-20

    Pediatric patients with severe chronic kidney disease (CKD) on conservative treatment, on dialysis, and those with renal transplantation are at a higher risk for infectious diseases as the result of impaired immune responses against infectious agents. Infections in these patients can have drastic consequences for disease morbidity and mortality. Immunization is a crucial preventive strategy for disease management in this pediatric population. However, vaccination coverage among children with CKD remains low due to safety concerns and doubts about vaccine immunogenicity and efficacy. In this study, we reviewed why children with CKD are at higher risk of infections, the importance of vaccinations among these children, barriers to vaccinations, and recommend the best vaccination schedules. Overall, vaccines have acceptable immunogenicity, efficacy, and safety profiles in children with CKD. However, in some cases, the protective antibody levels induced by vaccines and the benefits and risks of booster vaccine doses must be individually managed. Furthermore, close contacts and household members of these children should complete age-appropriate vaccination schedules to increase the child's indirect protection.

  14. Child labor

    OpenAIRE

    Udry, Christopher

    2007-01-01

    In recent years, there has been an astonishing proliferation of empirical work on child labor. An Econlit search of keywords "child lab*r" reveals a total of 6 peer reviewed journal articles between 1980 and 1990, 65 between 1990 and 2000, and 143 in the first five years of the present decade. The purpose of this essay is to provide a detailed overview of the state of the recent empirical literature on why and how children work as well as the consequences of that work. Section 1 defines terms...

  15. CHILD ALLOWANCE

    CERN Multimedia

    Human Resources Division

    2001-01-01

    HR Division wishes to clarify to members of the personnel that the allowance for a dependent child continues to be paid during all training courses ('stages'), apprenticeships, 'contrats de qualification', sandwich courses or other courses of similar nature. Any payment received for these training courses, including apprenticeships, is however deducted from the amount reimbursable as school fees. HR Division would also like to draw the attention of members of the personnel to the fact that any contract of employment will lead to the suppression of the child allowance and of the right to reimbursement of school fees.

  16. Child abuse

    International Nuclear Information System (INIS)

    Child abuse is common in most, if not all, Western nations; it probably occurs worldwide. It may be a major factor in the increase in violence throughout much of the world. Radiologists who treat children should think of the possibilitys of abuse whenever they diagnose a fracture, intracranial bleed, ar visceral injury, especially when the history is not compatible with their findings. Metaphyseal 'corner' fractures in infants usually are caused by abuse. Less than 20% of abused children, however, present injuries that can be recognized by radiologic techniques. Consequently normal roentgenograms, nuclear medicine scans, ultrasound studies, and computed tomograms do not exclude child abuse. (orig.)

  17. Prevent Child Abuse America

    Science.gov (United States)

    ... call the police . Crisis and support contacts For Child Abuse Reporting Numbers in your State please visit: Child ... suspected child abuse and neglect. Parent Resources Prevent Child Abuse America (800) CHILDREN A resource for tips, referrals, ...

  18. Typhoid fever vaccination strategies.

    Science.gov (United States)

    Date, Kashmira A; Bentsi-Enchill, Adwoa; Marks, Florian; Fox, Kimberley

    2015-06-19

    Typhoid vaccination is an important component of typhoid fever prevention and control, and is recommended for public health programmatic use in both endemic and outbreak settings. We reviewed experiences with various vaccination strategies using the currently available typhoid vaccines (injectable Vi polysaccharide vaccine [ViPS], oral Ty21a vaccine, and injectable typhoid conjugate vaccine [TCV]). We assessed the rationale, acceptability, effectiveness, impact and implementation lessons of these strategies to inform effective typhoid vaccination strategies for the future. Vaccination strategies were categorized by vaccine disease control strategy (preemptive use for endemic disease or to prevent an outbreak, and reactive use for outbreak control) and vaccine delivery strategy (community-based routine, community-based campaign and school-based). Almost all public health typhoid vaccination programs used ViPS vaccine and have been in countries of Asia, with one example in the Pacific and one experience using the Ty21a vaccine in South America. All vaccination strategies were found to be acceptable, feasible and effective in the settings evaluated; evidence of impact, where available, was strongest in endemic settings and in the short- to medium-term. Vaccination was cost-effective in high-incidence but not low-incidence settings. Experience in disaster and outbreak settings remains limited. TCVs have recently become available and none are WHO-prequalified yet; no program experience with TCVs was found in published literature. Despite the demonstrated success of several typhoid vaccination strategies, typhoid vaccines remain underused. Implementation lessons should be applied to design optimal vaccination strategies using TCVs which have several anticipated advantages, such as potential for use in infant immunization programs and longer duration of protection, over the ViPS and Ty21a vaccines for typhoid prevention and control.

  19. Measles vaccine coverage and factors related to uncompleted vaccination among 18-month-old and 36-month-old children in Kyoto, Japan

    Directory of Open Access Journals (Sweden)

    Okamoto Shigeru

    2005-06-01

    Full Text Available Abstract Background Due to low vaccine coverage, Japan has not only experienced outbreaks of measles but has also been exporting it overseas. This study aims to survey measles vaccine coverage and the factors uncompleted vaccination among community-living children. Methods Subjects were the parents whose children had undergone either an 18-month or a 36-month checkup publicly provided by Kyoto City during November 2001 to January 2002. An anonymous self-administered questionnaire survey was conducted. Results The coverage was 73.2% among the 18-month-old children (n = 2707 and 88.9% among the 36-month-old children (n = 2340, respectively. The following characteristics of mothers were related to uncompleted measles vaccination: aged below 30, working, concerned about the adverse events of the vaccine, and had insufficient knowledge. Similarly, the following characteristics among children were related to uncompleted measles vaccination: not the first-born child, interacting with other children in group settings. The coverage was the lowest among the children whose mothers were concerned about the adverse events of the vaccine without proper knowledge of measles and its vaccination. Conclusion To increase vaccine coverage among children, parents' awareness about measles and vaccination against it should be promoted, especially for working mothers. Efforts to enhance access to vaccination services and to communicate with parents about changing vaccination schedules are necessary.

  20. Who Should Not Get Vaccinated with These Vaccines?

    Science.gov (United States)

    ... be updated.) Top of Page HPV-Cervarix (Human Papillomavirus) vaccine Some people should not get HPV vaccine or ... updated.) Top of Page HPV-Gardasil-9 (Human Papillomavirus) vaccine Some people should not get HPV vaccine. Anyone ...