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  1. Prevalence of Mental Illness, Cognitive Disability, and Their Overlap among the Homeless in Nagoya, Japan

    OpenAIRE

    Nishio, Akihiro; Yamamoto, Mayumi; Horita, Ryo; Sado, Tadahiro; Ueki, Hirofumi; Watanabe, Takahiro; Uehara, Ryosuke; Shioiri, Toshiki

    2015-01-01

    Background While the prevalence of mental illness or cognitive disability is higher among homeless people than the general population in Western countries, few studies have investigated its prevalence in Japan or other Asian countries. The present study conducted a survey to comprehensively assess prevalence of mental illness, cognitive disability, and their overlap among homeless individuals living in Nagoya, Japan. Methods Participants were 114 homeless individuals. Mental illness was diagn...

  2. Japanse excursie- en workshopindrukken XIX INQUA 2015 congres, Nagoya, Japan

    NARCIS (Netherlands)

    Cohen, K.M.; Busschers, Freek S.

    2015-01-01

    Afgelopen juli en augustus waren wij twee weken in Japan als deelnemers van INQUA’s vierjaarlijkse internationale Kwartairgeologische congres. Vóór het eigenlijke congres hebben we deelgenomen aan de PALSEA2 workshop (Paleo constraints on sea-level rise) en gingen we met collega’s van de Japanse

  3. Occupation and bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan.

    Science.gov (United States)

    Morrison, A S; Ahlbom, A; Verhoek, W G; Aoki, K; Leck, I; Ohno, Y; Obata, K

    1985-12-01

    Relations between occupational history and the development of cancer of the lower urinary tract ("bladder cancer") were evaluated in Boston, Massachusetts, USA, Manchester, UK, and Nagoya, Japan. Population-based series of incident cases and controls were identified and interviewed in each area. The present analysis was limited to men and was based on 430 cases and 397 controls in Boston, 399 cases and 493 controls in Manchester, and 226 cases and 443 controls in Nagoya. In Boston, elevated risk of bladder cancer was associated with employment related to dyes (relative risk = 2 X 1; 90% confidence interval, 0 X 9-5 X 1), leather (1 X 7; 1 X 1-2 X 6), paint (1 X 5; 0 X 9-2 X 4), or organic chemicals (1 X 6; 1 X 1-2 X 5). In Manchester, elevated risk was associated with 0 X 9-3 X 6). No clear association was observed between occupation and risk in Nagoya. Elevations in risk related to occupation generally were stronger in men under 65 years of age compared to older men. Differences from place to place in associations between occupation and risk may be the result of differences in the exposures to hazardous agents that jobs with the same title involve.

  4. The effect of public awareness campaigns on suicides: evidence from Nagoya, Japan.

    Science.gov (United States)

    Matsubayashi, Tetsuya; Ueda, Michiko; Sawada, Yasuyuki

    2014-01-01

    Public awareness campaigns about depression and suicide have been viewed as highly effective strategies in preventing suicide, yet their effectiveness has not been established in previous studies. This study evaluates the effectiveness of a public-awareness campaign by comparing suicide counts before and after a city-wide campaign in Nagoya, Japan, where the city government distributed promotional materials that were aimed to stimulate public awareness of depression and promote care-seeking behavior during the period of 2010-2012. In each of the sixteen wards of the city of Nagoya, we count the number of times that the promotional materials were distributed per month and then examine the association between the suicide counts and the frequency of distributions in the months following such distributions. We run a Poisson regression model that controls for the effects of ward-specific observed and unobserved heterogeneities and temporal shocks. Our analysis indicates that more frequent distribution of the campaign material is associated with a decrease in the number of suicides in the subsequent months. The campaign was estimated to have been especially effective for the male residents of the city. The underlying mechanism of how the campaign reduced suicides remains to be unclear. Public awareness campaigns can be an effective strategy in preventing suicide. © 2013 Elsevier B.V. All rights reserved.

  5. In memory of Professor Leonor Michaelis in Nagoya: great contributions to biochemistry in Japan in the first half of the 20th century.

    Science.gov (United States)

    Nagatsu, Toshiharu Toshi

    2013-09-02

    Leonor Michaelis spent the years of 1922-1926 as Professor of Biochemistry of the Aichi Medical College (now Graduate School of Medicine, Nagoya University) in Nagoya, Japan. Michaelis succeeded in gathering many bright young biochemists from all over Japan into his laboratory, and made tremendous contributions to the promotion of biochemistry in Japan. Michaelis was invited to many places in Japan to present lectures over those years. Kunio Yagi, who was Professor of Biochemistry at Nagoya University in the second half of the 20th century, succeeded in crystallizing the "Michaelis" enzyme-substrate complex. Historically, Michelis has had an enormous impact on biochemistry in Japan. Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  6. Prevalence of Mental Illness, Cognitive Disability, and Their Overlap among the Homeless in Nagoya, Japan.

    Science.gov (United States)

    Nishio, Akihiro; Yamamoto, Mayumi; Horita, Ryo; Sado, Tadahiro; Ueki, Hirofumi; Watanabe, Takahiro; Uehara, Ryosuke; Shioiri, Toshiki

    2015-01-01

    While the prevalence of mental illness or cognitive disability is higher among homeless people than the general population in Western countries, few studies have investigated its prevalence in Japan or other Asian countries. The present study conducted a survey to comprehensively assess prevalence of mental illness, cognitive disability, and their overlap among homeless individuals living in Nagoya, Japan. Participants were 114 homeless individuals. Mental illness was diagnosed based on semi-structured interviews conducted by psychiatrists. The Wechsler Adult Intelligence Scale-III (WAIS-III, simplified version) was used to diagnose intellectual/ cognitive disability. Among all participants, 42.1% (95% CI 33.4-51.3%) were diagnosed with a mental illness: 4.4% (95% CI 1.9-9.9%) with schizophrenia or other psychotic disorder, 17.5% (95% CI 11.6-25.6%) with a mood disorder, 2.6% (95% CI 0.9-7.5%) with an anxiety disorder, 14.0% (95% CI 8.8-21.6%) with a substance-related disorder, and 3.5% (95% CI 1.4-8.8%) with a personality disorder. Additionally, 34.2% (95% CI 26.1-43.3%) demonstrated cognitive disability: 20.2% (95% CI 13.8-28.5%) had mild and 14.0% (95% CI 8.8-21.6%) had moderate or severe disability. The percent overlap between mental illness and cognitive disability was 15.8% (95% CI 10.2-23.6%). Only 39.5% (95% CI 26.1-43.3%) of the participants were considered to have no psychological or cognitive dysfunction. Participants were divided into four groups based on the presence or absence of mental illness and/or cognitive disability. Only individuals with a cognitive disability reported a significant tendency toward not wanting to leave their homeless life. This is the first report showing that the prevalence of mental illness and/or cognitive disability among homeless individuals is much higher than in the general Japanese population. Appropriate support strategies should be devised and executed based on the specificities of an individual's psychological and

  7. Prevalence of Mental Illness, Cognitive Disability, and Their Overlap among the Homeless in Nagoya, Japan.

    Directory of Open Access Journals (Sweden)

    Akihiro Nishio

    Full Text Available While the prevalence of mental illness or cognitive disability is higher among homeless people than the general population in Western countries, few studies have investigated its prevalence in Japan or other Asian countries. The present study conducted a survey to comprehensively assess prevalence of mental illness, cognitive disability, and their overlap among homeless individuals living in Nagoya, Japan.Participants were 114 homeless individuals. Mental illness was diagnosed based on semi-structured interviews conducted by psychiatrists. The Wechsler Adult Intelligence Scale-III (WAIS-III, simplified version was used to diagnose intellectual/ cognitive disability.Among all participants, 42.1% (95% CI 33.4-51.3% were diagnosed with a mental illness: 4.4% (95% CI 1.9-9.9% with schizophrenia or other psychotic disorder, 17.5% (95% CI 11.6-25.6% with a mood disorder, 2.6% (95% CI 0.9-7.5% with an anxiety disorder, 14.0% (95% CI 8.8-21.6% with a substance-related disorder, and 3.5% (95% CI 1.4-8.8% with a personality disorder. Additionally, 34.2% (95% CI 26.1-43.3% demonstrated cognitive disability: 20.2% (95% CI 13.8-28.5% had mild and 14.0% (95% CI 8.8-21.6% had moderate or severe disability. The percent overlap between mental illness and cognitive disability was 15.8% (95% CI 10.2-23.6%. Only 39.5% (95% CI 26.1-43.3% of the participants were considered to have no psychological or cognitive dysfunction. Participants were divided into four groups based on the presence or absence of mental illness and/or cognitive disability. Only individuals with a cognitive disability reported a significant tendency toward not wanting to leave their homeless life.This is the first report showing that the prevalence of mental illness and/or cognitive disability among homeless individuals is much higher than in the general Japanese population. Appropriate support strategies should be devised and executed based on the specificities of an individual's psychological

  8. Prevalence of mental illness, intellectual disability, and developmental disability among homeless people in Nagoya, Japan: A case series study.

    Science.gov (United States)

    Nishio, Akihiro; Yamamoto, Mayumi; Ueki, Hirofumi; Watanabe, Takahiro; Matsuura, Kenshin; Tamura, Osamu; Uehara, Ryosuke; Shioiri, Toshiki

    2015-09-01

    While it has been reported that the prevalence of mental illness is higher in homeless people than in the national population, few studies have investigated the prevalence of intellectual and developmental disability among the homeless. In this study, we conducted a survey to comprehensively assess these mental problems among homeless people in Nagoya, Japan. The subjects were 18 homeless men. Mental illness was diagnosed with semi-structured interviews conducted by psychiatrists. We used the Wechsler Adult Intelligence Scale III to diagnose intellectual disability. Discrepancies between Wechsler Adult Intelligence Scale III subtest scores were used as criteria for developmental disability. Eleven of the 18 participants were diagnosed with mental illness: six with mood disorder, two with psychotic disorder, and six with alcohol problems. The mean IQ of all subjects was 83.4 ± 27.4. The 95% confidence interval (CI) was 96.2-69.1. Seven participants were found to have intellectual disability. Three men showed discrepancies of more than 10 between subtest scores, and all of them were diagnosed with a mental illness. We divided the participants into four groups: those with mental illness only; those with intellectual disability only; those with both problems; and those without diagnosis. The men with intellectual disability only were significantly younger and had been homeless since a younger age than the other groups. Participants diagnosed with a mental illness had been homeless for longer than those without mental health problems. Although the sample size was limited, this study revealed the high prevalence of mental illness and intellectual disability, 61% (95%CI, 35-83%) and 39% (95%CI, 17-64%), respectively, in homeless people in Nagoya, Japan. © 2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology.

  9. Influence of contemporary carbon originating from the 2003 Siberian forest fire on organic carbon in PM2.5 in Nagoya, Japan

    International Nuclear Information System (INIS)

    Ikemori, Fumikazu; Honjyo, Koji; Yamagami, Makiko; Nakamura, Toshio

    2015-01-01

    In May 2003, high concentrations of organic carbon (OC) in PM 2.5 were measured in Nagoya, a representative metropolitan area in Japan. To investigate the influence of possible forest fires on PM 2.5 in Japan via long-range aerosol transport, the radiocarbon ( 14 C) concentrations of PM 2.5 samples from April 2003 to March 2004 were measured. 14 C concentrations in total carbon (TC) from May to early June showed higher values than those in other periods. The OC/elemental carbon (EC) ratios from May to early June were also significantly higher than the ones in other periods. In addition, OC concentrations from May to early June were typically high. These results indicate that the abundant OC fraction from May to early June in Nagoya consisted predominantly of contemporary carbon. Furthermore, simulations of diffusion and transport of organic matter (OM) in East Asia showed that abundant OM originating from East Siberia spread over East Asia and Japan in May and early June. Backward air mass trajectories from this time frame indicate that the air mass in Nagoya likely first passed through East Siberia where fire events were prevalent. However, the backward trajectories showed that the air mass after early June did not originate mainly from Siberia, and correspondingly, the 14 C and OC concentrations showed lower values than those from May to early June. Therefore, the authors conclude that contemporary carbon originating from the forest fire in East Siberia was transported to Nagoya, where it significantly contributed to the high observed concentrations of both OC and 14 C. - Highlights: • We analyzed the radiocarbon ( 14 C) concentration of TC in PM 2.5 from Nagoya, Japan. • 14 C concentrations from May to early June in 2003 were elevated. • The air mass at this time in Nagoya likely first passed through East Siberia. • Fire location data from MODIS indicate that fire events were prevalent in East Siberia. • Contemporary carbon emitted from the Siberian

  10. Influence of contemporary carbon originating from the 2003 Siberian forest fire on organic carbon in PM2.5 in Nagoya, Japan.

    Science.gov (United States)

    Ikemori, Fumikazu; Honjyo, Koji; Yamagami, Makiko; Nakamura, Toshio

    2015-10-15

    In May 2003, high concentrations of organic carbon (OC) in PM2.5 were measured in Nagoya, a representative metropolitan area in Japan. To investigate the influence of possible forest fires on PM2.5 in Japan via long-range aerosol transport, the radiocarbon ((14)C) concentrations of PM2.5 samples from April 2003 to March 2004 were measured. (14)C concentrations in total carbon (TC) from May to early June showed higher values than those in other periods. The OC/elemental carbon (EC) ratios from May to early June were also significantly higher than the ones in other periods. In addition, OC concentrations from May to early June were typically high. These results indicate that the abundant OC fraction from May to early June in Nagoya consisted predominantly of contemporary carbon. Furthermore, simulations of diffusion and transport of organic matter (OM) in East Asia showed that abundant OM originating from East Siberia spread over East Asia and Japan in May and early June. Backward air mass trajectories from this time frame indicate that the air mass in Nagoya likely first passed through East Siberia where fire events were prevalent. However, the backward trajectories showed that the air mass after early June did not originate mainly from Siberia, and correspondingly, the (14)C and OC concentrations showed lower values than those from May to early June. Therefore, the authors conclude that contemporary carbon originating from the forest fire in East Siberia was transported to Nagoya, where it significantly contributed to the high observed concentrations of both OC and (14)C. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Assessment of CCN based on size-resolved hygroscopicity data: Results from urban aerosol measurements in Nagoya, Japan

    Science.gov (United States)

    Kawana, K.; Nakayama, T.; Mochida, M.

    2012-12-01

    To assess the number concentrations and the proportion of cloud condensation nuclei (CCN) and the CCN activation diameter (dact) of urban aerosols based on size-resolved hygroscopicity, the atmospheric observation was performed for 10 days at an urban site of Nagoya, Japan in September 2009. The hygroscopic growth factor (HGF) distributions of aerosol particles at 85% RH were measured using a hygroscopicity tandem differential mobility analyzer (HTDMA) system, which consists of two differential mobility analyzers (DMAs) and a condensation particle counter (CPC). The proportion of CCN in the aerosol particles exiting the first DMA of the HTDMA was measured using a CCN counter and a CPC. The number concentrations of CCN (NCCN), the ratio of NCCN to the number concentrations of condensation nuclei (NCN), and dact were predicted from the observed HTDMA data based on k-köhler theory, and they were compared with measured values. Here, measured NCCN is that obtained from the number-size distribution of aerosol particles and the size-resolved NCCN/NCN. The measured dact was obtained from a curve fit to a CCN efficiency spectrum. The dact was predicted using different two methods. Whereas one of the methods to predict dact is based on the mean hygroscopic growth factor (gmean) at each diameter, the other accounts for activation of aerosol particles at each HGF bin. The NCCN and NCCN/NCN were predicted using the latter method only. The predicted NCCN and the predicted NCCN/NCN were, respectively, on average 19% and 15% lower than the measured values. The predicted dact were on average 8% higher than the measured values by both of the methods.

  12. Properties of light-absorbing aerosols in the Nagoya urban area, Japan, in August 2011 and January 2012: Contributions of brown carbon and lensing effect

    Science.gov (United States)

    Nakayama, Tomoki; Ikeda, Yuka; Sawada, Yuuki; Setoguchi, Yoshitaka; Ogawa, Shuhei; Kawana, Kaori; Mochida, Michihiro; Ikemori, Fumikazu; Matsumoto, Kiyoshi; Matsumi, Yutaka

    2014-11-01

    The optical properties of aerosols at 405 and 781 nm were measured in an urban site in Nagoya, Japan, in August 2011 and in January 2012 using a photoacoustic spectrometer. Comparison of the absorption coefficient at 781 nm of aerosols that did and did not pass through a thermo-denuder showed that an increase in black carbon (BC) light absorption due to the coating of non-refractory materials (i.e., the lensing effect) was small (on average, 10%) in August and negligible in January. The effective density distributions for the particles that did and did not pass through the thermo-denuder, which were measured simultaneously in August, suggested that the majority of BC particles sampled had a minimal coating. The small lensing effect observed can be explained partly by assuming that a large portion of non-refractory materials was mixed externally with BC. The contribution of direct light absorption by organic matter (OM) that vaporized at temperatures below 300°C to the total light absorption at 405 nm was negligible in August, but those by OM that vaporized below 300 and 400°C averaged 11 and 17%, respectively, in January. The larger contribution of light-absorbing OM in January is likely due to the greater contribution of OM originating from the burning of biomass, including biofuel and agricultural residue, in Japan, northern China, or Siberia, during the winter.

  13. [Engineering education reform plan created by Prof. Dr. Shimizu and establishment of Nagoya Municipal Science Museum--regarding cooperative education between universities and industries in Japan after the Second World War].

    Science.gov (United States)

    Mabuchi, Koichi

    2014-07-01

    This paper gives an account of Prof. Dr. Kinji Shimizu, the first president of Nagoya Institute of Technology, and his establishment of Nagoya Municipal Science Museum. After graduating from the Electrical Engineering Department of Kyoto Imperial University in 1923, Shimizu was impressed by the German Museum in Munich during his stay there as a student in 1932. It's the first time that he learned the education in cooperation with industries. Just after the Second World War, he became director general of the Ministry of Education. However, new education system given by the United States focused not on developing practical ability but on gaining the basic knowledge, which is contrary to what he expected. Then, he contributed to the establishment of the Japanese Society for Engineering Education, besides working as the president of Nagoya Institute of Technology in the earlier 1950s. His idea was supported by industries for the economic growth. Throughout his career, Prof. Dr. Shimizu was convinced that practical engineering education would benefit Japan, and wanted to introduce cooperative education between universities and industries, along the lines of the same system in Germany and the United States. With this vision he founded Nagoya Municipal Science Museum in cooperation with local industries and local government as his final achievement. The museum was completed in 1964.

  14. Research project at Nagoya University

    International Nuclear Information System (INIS)

    Furukawa, M.; Nakai, N.; Nakano, E.

    1981-01-01

    We will have a dedicated facility from General Ionex Corporation at the Radioisotope Center of Nagoya Univeriy in 1981 FY. The building to install the machine was already completed in March 1981. We have held meetings of potential users of the facility and various research proposals have been presented by the participants from many departments of the university. The present research project at Nagoya is mainly devoted to the development of radiocarbon dating by the accelerator mass spectrometry, in which most of the users are interested. There are many archeological and geological samples in Japan which have too little carbon compounds for analysis by conventional radioactivity measurements. Concentrations of 14 C in these samples can be determined by the new technique. Some of the proposals connected with radiocarbon measurements are discussed

  15. PREFACE: Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009)

    Science.gov (United States)

    Tanaka, Isao; Hafner, Jürgen; Wimmer, Erich; Asahi, Ryoji

    2010-09-01

    . Lectures and poster presentations were thus solicited from leading international academic and industrial researchers. The large audience that attended responded to the high quality of the talks with pertinent questions and lively discussions. The third workshop, TMI2009, was held over three days from 11-13 November, 2009, at the Nagoya International Center, Nagoya, Japan. Invited talks were given by 23 speakers from 9 countries from both the academic and industry sectors. The speakers were Ryoji Asahi (Toyota Central R&D Labs, Japan), Tomas Bucko (University of Vienna, Austria), Gábor Csányi (University of Cambridge, UK), Alessandro De Vita (King's College London, UK), Bernard Delley (Paul Scherrer Institute, Switzerland), Christophe Domain (EDF, France), George Fitzgerald (Accelrys, USA), Takeo Fujiwara (University of Tokyo, Japan), Jürgen Hafner (University of Vienna, Austria), Masaya Ishida (Sumitomo Chemicals, Japan), Werner Janse Van Rensburg (Sasol Technology, South Africa), Masanori Kohyama (AIST, Japan), Takao Kotani (Tottori University, Japan), Georg Kresse (University of Vienna, Austria), Katsuyuki Matsunaga (Kyoto University, Japan), Stefan Müller (University of Erlangen-Nuremberg, Germany), Shin-ichiro Nakamura (Mitsubishi Chemicals, Japan), Fumiyasu Oba (Kyoto University, Japan), Tamio Oguchi (Hiroshima University, Japan), Pascal Raybaud (IFP, France), Isao Tanaka (Kyoto University/JFCC, Japan), Göran Wahnström (Chalmers University of Technology, Sweden), and Erich Wimmer (Materials Design Inc., USA). There were 40 poster presentations in total. The workshop was attended by approximately 120 participants with approximately 50 per cent from industry. The invited talks covered advances in ab initio solid-state calculations and their practical use in industry. Presentations outlining the progress made in treating large and complex systems, as well as more accurate and efficient calculation methods, were given from the theory side. Examples of the use of ab

  16. PREFACE: Proceedings of the First International Workshop on the Theoretical Calculation of ELNES and XANES (TEX2008) (Nagoya, Japan, 2-4 July 2008) Proceedings of the First International Workshop on the Theoretical Calculation of ELNES and XANES (TEX2008) (Nagoya, Japan, 2-4 July 2008)

    Science.gov (United States)

    Tanaka, Isao; Mizoguchi, Teruyasu; Yamamoto, Tomoyuki

    2009-03-01

    -or-less independently by the two communities. The three-day workshop on the Theoretical Calculation of ELNES and XANES (TEX2008) was planned to help remedy this situation. It aimed to demonstrate capability of state-of-the-art theoretical techniques to explain and predict ELNES and XANES spectra, and to allow deep discussion between scientists in the two communities. It also provided an excellent opportunity to introduce experimentalists to the computational techniques available. Invited talks and poster presentations by leading scientists were given on the first day, which was followed by tutorial sessions for five computer programs on the second and third days. Excellent lectures were given by Peter Blaha (Vienna, Austria) on the WIEN2k code, Chris J Pickard (St Andrews, UK) on the CASTEP code, John J Rehr (Seattle, USA) on the FEFF8 code, Frank de Groot (Utrecht, The Netherlands) on the CTM4XAS code, and Hidekazu Ikeno (Kyoto, Japan) on the first-principles CI-multiplet code. Thanks to the enthusiastic participation of more than 100 scientists from around the world, the workshop was a complete success. The aim of this special issue in Journal of Physics: Condensed Matter is to share with the readers the most up-to-date knowledge presented at the workshop. We believe this will prove useful as a reference for researchers in many different fields, as well as an overview of the current status and future directions of theoretical calculations for ELNES and XANES. TEX2008 was a satellite meeting of the First International Symposium on Advanced Microscopy and Theoretical Calculations (AMTC1) (Nagoya, Japan, 29-30 June 2008), which was held in commemoration of the establishment of the Nanostuctures Research Laboratory (NSRL) at the Japan Fine Ceramics Center (JFCC) and as a daughter event of EXPO 2005, Aichi, Japan. A Grant-in-Aid for Scientific Research on Priority Areas 'Nano Materials Science for Atomic-Scale Modification' from the Ministry of Education, Culture, Sports and Technology

  17. The Nagoya Protocol and Indigenous Peoples

    Directory of Open Access Journals (Sweden)

    Maria Yolanda Teran

    2016-07-01

    Full Text Available This article is about Indigenous peoples’ involvement in the Nagoya Protocol negotiations from 2006 to 2010, as well as in its implementation to stop biopiracy in order to protect Pachamama, Mother Earth, and to ensure our survival and the survival of coming generations. The Nagoya Protocol is an international instrument that was adopted in Nagoya, Japan in October 2010 by the Conference of Parties (COP 10 and ratified by 51 countries in Pyeongchang, South Korea in October 2014 at COP 12. This protocol governs access to genetic resources and the fair and equitable sharing of benefits arising from their utilization (access and benefit sharing [ABS]. It has several articles related to Indigenous peoples and traditional knowledge, as well as: The interrelation and inseparable nature between genetic resources and traditional knowledge; The diversity of circumstances surrounding traditional knowledge ownership, including by country; The identification of traditional knowledge owners; The declaration of Indigenous peoples' human rights; and The role of women in the biodiversity process. In addition, this protocol lays out obligations on access, specifically participation in equitable benefit sharing, the accomplishment of prior and informed consent, and the mutually agreed terms and elaboration of a national legal ABS framework with the participation of Indigenous peoples and local communities in order to have well-defined roles, responsibilities, and times of negotiations.

  18. Automatically operated maglev public transport line in Nagoya

    Energy Technology Data Exchange (ETDEWEB)

    Hibi, Osamu [Aichi Rapid Transit Co., Aichi Prefecture (Japan). Engineering Dept.

    2006-07-01

    Tobu-Kyuryo-Line in Nagoya (Japan) is a mid-size automatically operated passenger line which adopts the HSST (high-speed surface transport) system. The vehicles are levitated with normal conducting electromagnets and propelled by a linear induction motor. Low noise by levitation and stable acceleration by the linear induction motor improve the riding comfort and ensure a faster transportation. Automatic operation is indispensable for stable operation and reduction of running costs. In the opening year, the Tobu-Kyuryo-Line played an important role as an access to EXPO2005 by carrying 20 million passengers. So far it had no serious trouble and has been operated safely. (orig.)

  19. Current nursing practice for patients on oral chemotherapy: a multicenter survey in Japan.

    Science.gov (United States)

    Komatsu, Hiroko; Yagasaki, Kaori; Yoshimura, Kimio

    2014-04-23

    With a paradigm shift toward a chronic care model in cancer, the issue of adherence is becoming increasingly important in oncology. We mailed two self-reported surveys on current nursing practices for patients on oral chemotherapy to all 309 designated cancer centers and 141 large general hospitals in Japan. The first survey was based on a nurse-based questionnaire containing 40 items concerning nurse's characteristics, nurse staffing at workplace, general nursing care for new patients on oral chemotherapy and those with refilled prescriptions, follow-up, and system-based approach. The second survey was based on a patient-based questionnaire containing 10 items about patient characteristics and adherence-related nursing practice for 249 patients taking oral chemotherapy of 903 systematically sampled. We used multivariate logistic regression to identify factors that were associated with adherence-related nursing practices. A total of 62 nurses (mean age: 41.5 years) from 62 hospitals who consented participated in the both nurse-based survey and patient-based survey about 249 patients. The results of nurse-based survey indicated that practices varied, but nurses were less likely to ask adherence-related questions of patients with refilled prescriptions than of new patients. The results of patient-based survey found that questions on side effects, discussions about barriers to achieving balance between treatment and daily life activities, and medication management were all significantly related to the question about unused medicines. Logistic regression revealed that adherence-related nursing practices were associated with the nurse's background, type of treatment, and healthcare system-related factors. Patient orientation on oral chemotherapy, interdisciplinary learning, and having a system-based approach for detecting prescription errors were identified as healthcare system-related factors. A more systematic approach must be developed to ensure patients receive

  20. Carbon isotope components of aerosol in Fukuoka, Nagoya, Suwa and Kamikochi

    International Nuclear Information System (INIS)

    Ikemori, Fumikazu; Higo, Hayato; Miyabara, Yuichi; Nakajima, Daisuke; Nakamura, Toshio

    2013-01-01

    To estimate the contributions of fossil carbon and biomass carbon in some regions in Japan, 14 C concentration of total carbon in Total suspended particles (TSP) was measured at four places (Nagoya, Fukuoka, Suwa and Kamikochi) in Japan. pMC (% Modern Carbon) showed lowest average value of pMC (50.5±5.6: n =43) in Nagoya. The average value of pMC in Fukuoka (56.7±7.7 : n=26) and Suwa (pMC=66.9±8.8 : n=12) were larger than the average value of pMC in Nagoya. In Kamikochi, the average value of pMC measured two samples only was largest pMC (102, 97.9) in four places. The correlations among organic carbon (OC), elemental carbon (EC), fossil carbon, biomass carbon and OC/EC showed different values in Nagoya, Fukuoka and Suwa. These results suggest that the carbon sources were different at three regions. (author)

  1. Factors related to self-efficacy among men and women undergoing outpatient chemotherapy in Japan.

    Science.gov (United States)

    Sato, Miho; Sumi, Naomi

    2015-12-01

    This study aims to examine factors that influence self-efficacy in Japanese patients with cancer receiving outpatient chemotherapy and to identify whether there are gender-specific similarities or differences that determine self-efficacy in this setting. A cross-sectional survey was conducted among 156 patients with cancer (86 men and 70 women) undergoing chemotherapy as outpatients across five hospitals in Japan. The patients completed the European Organization for Research and Cancer Core Quality of Life questionnaire (EORTC QLQ-C30), the Self-Efficacy for Advanced Cancer questionnaire (SEAC) which consists of three subscales (affect regulation efficacy, symptom-coping efficacy and activities of daily living efficacy), and a patient information form. Multiple regression analysis was conducted to identify factors associated with self-efficacy in men and women. In both men and women, insomnia was related to affect regulation efficacy, while fatigue and nausea/vomiting correlated with activities of daily living efficacy. For male patients, fatigue and nausea/vomiting also correlated with affect regulation efficacy and symptom-coping efficacy. Emotional functioning influenced self-efficacy for both genders, while physical functioning affected self-efficacy in female patients only. These results suggest that to enhance self-efficacy in Japanese patients with cancer undergoing outpatient chemotherapy, effective intervention is required with regard to the management of both emotional and physical functioning, specifically symptoms such as fatigue, nausea/vomiting and insomnia in both genders. Furthermore, women with a reduced level of physical function may require particular attention, as they may be at risk of lower levels of self-efficacy. © 2015 Nordic College of Caring Science.

  2. Vicissitudes of Nagoya Protocol in Colombia

    International Nuclear Information System (INIS)

    Rojas Blanco, Diana Lorena

    2013-01-01

    The fair and equitable sharing of benefits arising from the utilization of genetic resources is not only one of the central objectives of the Nagoya Protocol, but also a challenge for communities of scientists, researchers, and indigenous ancestral generally for the educational community. It is therefore essential to know what the real and material implications for the population, the ratification of the Nagoya Protocol, which despite having sufficient justification and argued, highlights the need to develop legal tools, economic, technological and education for proper and fair implementation.

  3. Real-world cost analysis of chemotherapy for colorectal cancer in Japan: detailed costs of various regimens during the entire course of chemotherapy.

    Science.gov (United States)

    Yajima, Shuichi; Shimizu, Hisanori; Sakamaki, Hiroyuki; Ikeda, Shunya; Ikegami, Naoki; Murayama, Jun-Ichiro

    2016-01-04

    Various chemotherapy regimens for advanced colorectal cancer have been introduced to clinical practice in Japan over the past decade. The cost profiles of these regimens, however, remain unclear in Japan. To explore the detailed costs of different regimens used to treat advanced colorectal cancer during the entire course of chemotherapy in patients treated in a practical setting, we conducted a so-called "real-world" cost analysis. A detailed cost analysis was performed retrospectively. Patients with advanced colorectal cancer who had received chemotherapy in a practical healthcare setting from July 2004 through October 2010 were extracted from the ordering system database of Showa University Hospital. Direct medical costs of chemotherapy regimens were calculated from the hospital billing data of the patients. The analysis was conducted from a payer's perspective. A total of 30 patients with advanced colorectal cancer were identified. Twenty patients received up to second-line treatment, and 8 received up to third-line treatment. The regimens identified from among all courses of treatment in all patients were 13 oxaliplatin-based regimens, 31 irinotecan-based regimens, and 11 regimens including molecular targeted agents. The average (95% confidence interval [95% CI]) monthly cost during the overall period from the beginning of treatment to the end of treatment was 308,363 (258,792 to 357,933) Japanese yen (JPY). According to the type of regimen, the average monthly cost was 418,463 (357,413 to 479,513) JPY for oxaliplatin-based regimens, 215,499 (188,359 to 242,639) JPY for irinotecan-based regimens, and 705,460 (586,733 to 824,187) JPY for regimens including molecular targeted agents. Anticancer drug costs and hospital fees accounted for 50 to 77% and 11 to 25% of the overall costs of chemotherapy, respectively. The costs of irinotecan-based regimens were lower than those of oxaliplatin-based regimens and regimens including molecular targeted agents in Japan

  4. Creating a Sustainable City through a System of Citizen-Based Learning: ESD at Nagoya Open University of the Environment

    Science.gov (United States)

    Chikami, Satoshi; Sobue, Kirstie

    2008-01-01

    In Japan, environmental education partnerships among citizens, businesses and local government increased since new legislation was introduced in 2003, but there was little evidence of cross-sector collaboration until recently. Nagoya Open University of the Environment is a highly innovative, multi-sectoral citizen learning system founded in 2005…

  5. Management of infection during chemotherapy for acute leukemia in Japan: a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group.

    Science.gov (United States)

    Kimura, Shun-Ichi; Fujita, Hiroyuki; Kato, Hideaki; Hiramoto, Nobuhiro; Hosono, Naoko; Takahashi, Tsutomu; Shigeno, Kazuyuki; Hatsumi, Naoko; Minamiguchi, Hitoshi; Miyatake, Junichi; Handa, Hiroshi; Akiyama, Nobu; Kanda, Yoshinobu; Yoshida, Minoru; Kiyoi, Hitoshi; Miyazaki, Yasushi; Naoe, Tomoki

    2017-11-01

    We performed a nationwide questionnaire-based survey to evaluate the current clinical practices of infectious complications during chemotherapy for acute leukemia in Japan. We e-mailed a questionnaire to member institutions of the Japan Adult Leukemia Study Group in September, 2013. The questionnaire consisted of 50 multiple-choice questions covering therapeutic environment, antimicrobial prophylaxis, screening test during neutropenia, empirical therapy for febrile neutropenia, and the use of granulocyte-colony stimulating factor. The results were compared to those of previous surveys conducted in 2001 and 2007, and also to the recommendations described in the guidelines. Usable responses were received from 141 out of 222 (63.5%) institutions. Chemotherapy for acute myeloid leukemia was performed in protective environment in 90% of the institutions, which increased compared to previous survey (76%). Fluoroquinolones and fluconazole were the most commonly used antimicrobial agents for antibacterial and antifungal prophylaxis, followed by sulfamethoxazole-trimethoprim and itraconazole, respectively. In empirical therapy for febrile neutropenia, monotherapy with β-lactum antibiotics was the first-line therapy in most of the institutions. While empirical antifungal therapy was adopted for persistent fever in more than half of the institutions, preemptive/presumptive therapy was also used in approximately 40% of the institutions. Most of the clinicians were reluctant to use granulocyte-colony stimulating factor routinely in chemotherapy for acute myeloid leukemia. This study clarified the current clinical practices of infectious complications during chemotherapy for acute leukemia and would provide important information for the development of a suitable guideline in Japan.

  6. The Nagoya Protocol: Fragmentation or Consolidation?

    Directory of Open Access Journals (Sweden)

    Carmen Richerzhagen

    2014-02-01

    Full Text Available In October, 2010, a protocol on access and benefit-sharing (ABS of genetic resources was adopted, the so-called Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity. Before the adoption of the Nagoya Protocol, the governance architecture of ABS was already characterized by a multifaceted institutional environment. The use of genetic resources is confronted with many issues (conservation, research and development, intellectual property rights, food security, health issues, climate change that are governed by different institutions and agreements. The Nagoya Protocol contributes to increased fragmentation. However, the question arises whether this new regulatory framework can help to advance the implementation of the ABS provisions of the Convention on Biological Diversity (CBD. This paper attempts to find an answer to that question by following three analytical steps. First, it analyzes the causes of change against the background of theories of institutional change. Second, it aims to assess the typology of the architecture in order to find out if this new set of rules will contribute to a more synergistic, cooperative or conflictive architecture of ABS governance. Third, the paper looks at the problem of “fit” and identifies criteria that can be used to assess the new ABS governance architecture with regard to its effectiveness.

  7. Right to Food and the Nagoya Protocol

    Directory of Open Access Journals (Sweden)

    Romina Ysabel Bazán Barba

    2016-12-01

    Full Text Available In the perspective of Environmental Law, the juridical-sociological aspect addresses the problem for the Right to Food, which has been intensified by the lack of equity, social justice and mainly by environmental degradation. Based on theoretical research, the Constitution and international treaties on the subject, the problem of hunger is studied, with emphasis on the Nagoya Protocol – a new international instrument for access and distribution of genetic resources. It aims to analyze the geopolitics behind the hunger issue; the indiscriminate use of agrochemicals; the monopoly of seeds; and the lives wasted in the process of maintenance/circulation in the food market.

  8. Microbiological Research Under the Nagoya Protocol: Facts and Fiction.

    Science.gov (United States)

    Overmann, Jörg; Scholz, Amber Hartman

    2017-02-01

    The Nagoya Protocol is based on concepts of biological diversity that are hardly applicable to microorganisms. Because of this incongruence, the Nagoya Protocol threatens future microbial research, potentially defeating its original purpose. Countries with appropriate regulations can promote science and their bioeconomy through international collaboration and simultaneously gain a competitive advantage. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Japan.

    Science.gov (United States)

    Geiger, Rita; And Others

    The document offers practical and motivating techniques for studying Japan. Dedicated to promoting global awareness, separate sections discuss Japan's geography, history, culture, education, government, economics, energy, transportation, and communication. Each section presents a topical overview; suggested classroom activities; and easily…

  10. Japan.

    Science.gov (United States)

    1989-02-01

    Japan consists of 3900 islands and lies off the east coast of Asia. Even though Japan is one of the most densely populated nations in the world, its growth rate has stabilized at .5%. 94% of all children go to senior high school and almost 90% finish. Responsibility for the sick, aged, and infirmed is changing from the family and private sector to government. Japan was founded in 600 BC and its 1st capital was in Nara (710-1867). The Portuguese, the 1st Westerners to make contact with Japan in 1542, opened trade which lasted until the mid 17th century. US Navy Commodore Matthew Perry forced Japan to reopen in 1854. Following wars with China and Russia in the late 1800s and early 1900s respectively, Japan took part in World Wars I and II. In between these wars Japan invaded Manchuria and China. The US dropped an atomic bomb on Hiroshima and Nagasaki and the Japanese surrendered in September, 1945 ending World War II (WWII). Following, WWII, the Allied Powers guided Japan's establishment as a nonthreatening nation and a democratic parliamentary government (a constitutional monarchy) with a limited defense force. Japan remains one of the most politically stable of all postwar democracies. The Liberal Democratic Party's Noboru Takeshita became prime minister in 1987. Japan has limited natural resources and only 19% of the land is arable. Japanese ingenuity and skill combine to produce one of the highest per hectare crop yields in the world. Japan is a major economic power, and its and the US economies are becoming more interdependent. Its exports, making up only 13% of the gross national product, mainly go to Canada and the US. Many in the US are concerned, however, with the trade deficit with Japan and are seeking ways to make trade more equitable. Japan wishes to maintain good relations with its Asian neighbors and other nations. The US and Japan enjoy a strong, productive relationship.

  11. Japan

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    2013-01-01

    I 1500- og 1600-tallet dannedes tidligt moderne stater i Europa, men samtidig eksisterede der ligeså avancerede statsdannelser uden for Europa, bl.a. i Kina, Indien og Japan. I det følgende ser vi nærmere på dannelsen af den moderne stat i Japan. Hvorfor blev Japan aldrig en europæisk koloni......? Hvordan havde japanske magthavere igennem 300 år forberedt Japan og de mennesker, der boede på de japanske øer, til at kunne udvikle en nation, der skulle blive den stærkeste og rigeste i Asien i mere end 100 år? Hvem bestemte i Japan? Kejseren eller shogunen?...

  12. KEK/NAGOYA/SLAC: Highly polarized electrons

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    In the push by the Japanese KEK Laboratory, in collaboration with university groups and overseas laboratories, to develop new techniques for the future Japan electronpositron collider (JLC), a recent achievement is a significant increase in the efficient yield of highly polarized electrons

  13. Survival after failure of first-line chemotherapy in advanced gastric cancer patients: differences between Japan and the rest of the world.

    Science.gov (United States)

    Takashima, Atsuo; Iizumi, Sakura; Boku, Narikazu

    2017-07-01

    In this review, we focus on post-progression survival after first-line chemotherapy of advanced gastric cancer, and particularly the differences between Japan and the rest of the world. We reviewed 15 recent phase III trials of which 4 were solely recruited from Japanese and 11 from rest of the world. The patient characteristics age, performance status, previous gastrectomy and the number of metastatic sites were similar in Japan and rest of the world. However, the diffuse histological type was more common in Japan. While overall survival was longer in Japan (10.5-14.1 vs. 7.9-12.2 months), progression-free survival tended to be shorter in Japan (3.6-6.0 vs. 3.1-7.4 months). Post-progression survival calculated as the difference between median overall survival and progression-free survival was clearly longer in Japan (6.9-8.6 vs. 2.4-6.2 months). The proportion of patients receiving second-line chemotherapy (%2nd-CX) was quite different in Japan and rest of the world (69-85% vs. 11-59%). Correlations between %2nd-CX and post-progression survival were strong (Spearman's rank correlation coefficient; ρ = 0.86, P < 0.001). Correlations between %2nd-CX and ratio of post-progression survival to total overall survival were also strong (ρ = 0.84, P < 0.001). Because a survival benefit of second-CX was documented in several phase III trials, it can be concluded that higher %2nd-CX partly contributed to extended post-progression survival. However, considering that second-CX increased survival only by ~1.5 months at median, other factors such as third-line chemotherapy may have some influences to prolonged post-progression survival. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Earthquake and Tsunami Disaster Mitigation in The Marmara Region and Disaster Education in Turkey Part2 Yoshiyuki KANEDA Nagoya University Japan Agency for Marine-Earth Science and Technology (JAMSTEC) Haluk OZENER Boğaziçi University, Earthquake Researches Institute (KOERI) and Members of SATREPS Japan-Turkey project

    Science.gov (United States)

    Kaneda, Y.; Ozener, H.

    2015-12-01

    The 1999 Izumit Earthquake as the destructive earthquake occurred near the Marmara Sea. The Marmara Sea should be focused on because of a seismic gap in the North Anatolian fault. Istanbul is located around the Marmara Sea, so, if next earthquake will occur near Istanbul, fatal damages will be generated. The Japan and Turkey can share our own experiences during past damaging earthquakes and we can prepare for future large earthquakes in cooperation with each other. In earthquakes in Tokyo area and Istanbul area as the destructive earthquakes near high population cities, there are common disaster researches and measures. For disaster mitigation, we are progressing multidisciplinary researches. Our goals of this SATREPS project are as follows, To develop disaster mitigation policy and strategies based on multidisciplinary research activities. To provide decision makers with newly found knowledge for its implementation to the current regulations. To organize disaster education programs in order to increase disaster awareness in Turkey. To contribute the evaluation of active fault studies in Japan. This project is composed of four research groups. The first group is Marmara Earthquake Source region observationally research group. This group has 4 sub-themes such as Seismicity, Geodesy, Electromagnetics and Trench analyses. The second group focuses on scenario researches of earthquake occurrence along the North Anatolia fault and precise tsunami simulation in the Marmara region. Aims of the third group are improvements and constructions of seismic characterizations and damage predictions based on observation researches and precise simulations. The fourth group is promoting disaster educations using research result visuals. In this SATREPS project, we will integrate these research results for disaster mitigation in Marmara region and .disaster education in Turkey. We will have a presentation of the updated results of this SATREPS project.

  15. Hotel "Nagoya Castle", Japón

    Directory of Open Access Journals (Sweden)

    Takenaka Komuten, Co. Ltd.

    1970-04-01

    Full Text Available This hotel has 254 rooms, of which 138 are single and 99 double bed rooms, and 9 rooms have twin beds. There are also 5 suites and 5 bedrooms in the Japanese style. It can accommodate in all 370 persons. Among its special facilities the following are noteworthy. A large dining hall, with room for 3 000 guests, this being the largest banquet hall in central Japan; a beautiful open air pool; a magnificent garden; and a parking site with space for 400 cars.Este hotel consta de 254 habitaciones, de ellas: 138 individuales, 99 dobles con una cama, 9 dobles con dos camas, 5 suites y 3 habitaciones ambientadas al estilo japonés. Tiene capacidad de alojamiento para 370 personas. Entre sus instalaciones especiales figuran: un gran salón de banquetes —para 3.000 comensales—, que es el mayor del Japón central; una bella piscina al aire libre; un magnífico jardín; y un estacionamiento con capacidad para aparcar 400 turismos.

  16. Human Resource Development for Knowledge-based Society and Challenges of Nagoya University

    Science.gov (United States)

    Miyata, Takashi

    Innovation in the previous century resulted in development of useful products ranging from automobiles and aircraft to cellular phones. However, the innovation and development of science and technology have changed the society and brought about negative issues. The issues emerged in the previous century remain in the excessive forms in the 21st century. The 21st century is seeing the rise of knowledge-based society, and paradigm shift is now going on. Human resources of university for creation of innovation are being called on to contribute to solving issues. Young people who pass through a doctor program must play a role as an innovator who can promote the paradigm shift. However, the higher education system of the universities in Japan is now required to be changed to dissolve the mismatch on the doctor program with industries, government and students. The discussion in the Business-University Forum of Japan for innovation of education system and a few challenges of the Nagoya University are introduced in this paper.

  17. Quassia "biopiracy" case and the Nagoya Protocol: A researcher's perspective.

    Science.gov (United States)

    Bourdy, Geneviève; Aubertin, Catherine; Jullian, Valérie; Deharo, Eric

    2017-07-12

    Biopiracy accusations are common in the world of biodiversity research. At the end of 2015, a French NGO accused researchers from the Institut de Recherche pour le Développement (IRD) of biopiracy. These researchers had applied for a patent for a natural bioactive molecule against malaria and cancer, the Simalikalactone E, isolated from Quassia amara L. (Simaroubaceae) leaves. This biopiracy allegation triggered a huge wave of attacks from the media and social networks, and vehement recrimination from political officials in French Guiana against researchers who have been accused of ethical misconduct, by stealing the traditional knowledge of indigenous people. These accusations were made in the contentious context of the ratification of the Nagoya Protocol in the frame of implementing the French law on biodiversity, nature and landscapes. So, in an atmosphere of heightened emotions it is crucial to understand the issues behind these accusations. We describe herein the genesis of our discovery, present the detractors' arguments, and discuss the consequences of such biopiracy denunciations for scientific research. We also address our concerns about the gap between rhetoric and reality and the real impact of the Nagoya Protocol on biodiversity conservation. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  18. Observations of interplanetary scintillation during the 1998 Whole Sun Month: a comparison between EISCAT, ORT and Nagoya data

    Directory of Open Access Journals (Sweden)

    P. J. Moran

    2000-09-01

    Full Text Available Observations of interplanetary scintillation (IPS allow accurate solar wind velocity measurements to be made at all heliographic latitudes and at a range of distances from the Sun. The data may be obtained with either single, double or multiple antennas, each requiring a different method of analysis. IPS data taken during the 1998 whole sun month (30th July-31st August 1998 by EISCAT, the ORT (Ooty Radio Telescope, India, and the Nagoya IPS system, Japan, allow the results of individual methods of analysis to be compared. Good agreement is found between the velocity measurements using each method, and when combined an improved understanding of the structure of the solar wind can be obtained.Key words: Interplanetary physics (solar wind plasma; sources of the solar wind - Solar physics, astrophysics and astronomy (instruments and techniques

  19. Small-mass AMS radiocarbon analysis at Nagoya University

    Energy Technology Data Exchange (ETDEWEB)

    Minami, Masayo, E-mail: minami@nendai.nagoya-u.ac.jp [Center for Chronological Research, Nagoya University, Chikusa, Nagoya 464-8602 (Japan); Kato, Tomomi [Faculty of Science, Nagoya University, Nagoya 464-8602 (Japan); Miyata, Yoshiki; Nakamura, Toshio [Center for Chronological Research, Nagoya University, Chikusa, Nagoya 464-8602 (Japan); Hua Quan [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia)

    2013-01-15

    As part of the ongoing development at the AMS facility of the Center for Chronological Research at Nagoya University to radiocarbon ({sup 14}C) analyze samples smaller than 0.5 mg carbon (mgC), a compact graphitization manifold has been built. Tests with various reference materials show it performs well for samples as small as 0.1 mgC. Preparation with this new system is compared with the performance of the older protocol for regular-sized samples. Furthermore, it is shown that the addition of Cu and Ag before and stepwise heating during sealed-tube combustion of samples with high S content improve the degree of conversion to CO{sub 2} without having to resort to special purification measures such as the use of Co{sub 3}O{sub 4} + Ag reagent and an n-pentane/LN{sub 2} trap before graphitization.

  20. Comparison between old and new noise standards in Nagoya City

    Science.gov (United States)

    Asai, Atsushi; Mishina, Yoshiaki; Oishi, Yasaki; Ogura, Toshimitsu; Hayashi, Akinori; Omiya, Masaaki; Kuno, Kazuhiro

    2004-10-01

    The Japanese Environmental Agency (now the Ministry of the Environment) updated the environmental quality standards for noise in April 1999. The new standards replaced the median value of percentile level L50 for noise evaluation with the equivalent sound pressure level LAeq. The standards renewed the classification of areas and time sections. The most significant change was the introduction of category of artery-road-adjacent area. This report sets the range of the artery-road-adjacent area to 20 m or less from the applicable road to compare the new standards with the old, based on data collected in Nagoya City. The achieved rates for the new standards seem to be on the whole the same as those for the old standards. However, a detailed analysis reveals some differences, such as higher achieved rates in the artery-road-adjacent areas and lower achieved rates in the general areas for the new standards than for the old.

  1. Changes in Urban Climate due to Future Land-Use Changes based on Population Changes in the Nagoya Region

    Science.gov (United States)

    Adachi, S. A.; Hara, M.; Takahashi, H. G.; Ma, X.; Yoshikane, T.; Kimura, F.

    2013-12-01

    Severe hot weather in summer season becomes a big social problem in metropolitan areas, including the Nagoya region in Japan. Surface air temperature warming is projected in the future. Therefore, the reduction of surface air temperature is an urgent issue in the urban area. Although there are several studies dealing with the effects of global climate change and urbanization to the local climate in the future, these studies tend to ignore the future population changes. This study estimates future land-use scenarios associated with the multi-projections of future population and investigates the impacts of these scenarios on the surface temperature change. The Weather Research and Forecast model ver. 3.3.1 (hereafter, WRF) was used in this study. The horizontal resolutions were 20km, 4km, and 2km, for outer, middle, and inner domains, respectively. The results from the inner domain, covering the Nagoya region, were used for the analysis. The Noah land surface model and the single-layer urban canopy model were applied to calculate the land surface processes and urban surface processes, respectively. The initial and boundary conditions were given from the NCEP/NCAR reanalysis data in August 2010. The urban area ratio used in the WRF model was calculated from the future land-use data provided by the S8 project. The land-use data was created as follows. (1) Three scenarios of population, namely, with high-fertility assumption and low-mortality assumption (POP-high), with medium-fertility assumption and medium-mortality assumption (POP-med), and with low-fertility assumption and high-mortality assumption (POP-low), are estimated using the method proposed by Ariga and Matsuhashi (2012). These scenarios are based on the future projections provided by the National Institute of Population and Social Security Research. (2) The future changes in urban area ratio were assumed to be proportional to the population change (Hanasaki et al., 2012). The averaged urban area ratio in

  2. Local Public Finance in Japan; Urban Affairs Paper No. 3.

    Science.gov (United States)

    Hicks, Ursula

    The three largest cities in Japan--Tokyo, Osaka and Nagoya--are used to examine the financial situation of Japanese urban areas. The 1949 Shoup Mission findings and recommendations are reviewed. Demographic data and information on the administrative and the fiscal organization of Japanese cities during the past three decades are presented. Details…

  3. Impact on the Food Industry of New EU Rules Implementing the Nagoya Protocol

    DEFF Research Database (Denmark)

    Van Vooren, Bart

    2016-01-01

    Regulation only encompasses bioprospecting or ethno-pharmacological R&D. Instead, the EU has purposely set up a broad regime that affects companies developing pharmaceuticals, cosmetics and biocides, as well as food, feed, beverages, and any of their components. This article summarizes the new EU Nagoya...... compliance regime, with examples drawn fromthe food sector to explain its impact....

  4. The Nagoya cosmic-ray muon spectrometer 3, part 3: Automatic film scanning equipment

    Science.gov (United States)

    Shibata, S.; Kamiya, Y.; Iijima, K.; Iida, S.

    1985-01-01

    In the regular operation of the Nagoya cosmic-ray muon spectrometer, about 2000 events per day will be recorded on the photographic film. To derive the track locations from such a huge number of photographs with high accuracy in a short time, an automatic film scanning device has been developed.

  5. Universidad de comercio de Nagoya – Japón

    Directory of Open Access Journals (Sweden)

    Komuten, Takenaka

    1973-12-01

    Full Text Available The group of buildings and installations of this college covers a wide area measuring 600,000 m2 on the outskirts of Nagoya. It consists of five main sectors: a NATURAL AREA, formed by a natural barrier of hills that surround the group. It takes care of minimizing outside environmental influences. b SPORTS AREA, to the est of the general site area on a North-South axis. It consists of two fields for baseball, soccor and rugby, a track, golf and a horse-riding area. c STUDENT UNION, located immediately to the east of the central area. This is the social nucleus of the group and consists of a cafeteria, gymnasium, and meeting rooms. d PLAZA AREA, located along the central axis of the college group itself. It is the linking area between the study buildings and the student union and sports installations. It is made up of various man-made parks and gardens and in the future will have underground parking. e STUDY BUILDINGS, including buildings with classrooms of different sizes, library, three seminar buildings and one for special classes. It is located to the west opposite the sports area and runs along a North-South axis. A covered passageway, adapted to the topography of the land, encircles all the college installations and links the various areas of the group.El conjunto de edificios e instalaciones universitarias se extiende en una amplia zona panorámica de 600.000 m2 en las afueras de Nanoya. Consta de cinco sectores principales: a ZONA DE NATURALEZA, formada por una barrera natural de colinas que rodea el conjunto. Es la encargada de minimizar las influencias del ambiente exterior. b ZONA DE DEPORTES, al este del emplazamiento general, siguiendo un eje norte a sur. Consta de: dos campos de pelota base, fútbol y rugby, pista de atletismo, golf y una zona para equitación. c ZONA DE COMUNICACIÓN, colocada inmediatamente al este de la parte central. Constituye el núcleo social del conjunto y está formada por: el comedor, el gimnasio y las

  6. Characterization of Aeolian Dust in East China and Japan from 2001 to 2003(ADEC-Aeolian Dust Experiment on Climate Impact-)

    OpenAIRE

    Yutaka, KANAI; Atsuyuki, OHTA; Hikari, KAMIOKA; Shigeru, TERASHIMA; Noboru, IMAI; Michiyo, KANAI; Hiroshi, SHIMIZU; Yoshio, TAKAHASHI; Kenji, KAI; Masahiko, HAYASHI; Renjian, ZHANG; Lifang, SHENG; Geological Survey of Japan (GSJ), National Institute of Advanced Industrial Science and Technology (AIST); Geological Survey of Japan (GSJ), National Institute of Advanced Industrial Science and Technology (AIST); Geological Survey of Japan (GSJ), National Institute of Advanced Industrial Science and Technology (AIST)

    2005-01-01

    In order to elucidate the variation and characterization of dust particles that originate in the arid and semi-arid regions of inland Asia and are transported to Japan, we established a sampling network system in east China and Japan and collected aeolian dust under the Japan-China joint project "ADEC". Monitoring of the total suspended particle (TSP) and size-segregated dust concentrations were carried out in Beijing, Qingdao and Hefei in China, and Fukuoka, Nagoya, Tsukuba and Naha in Japan...

  7. Recent progress on cathode development from Nagoya and KEK

    Energy Technology Data Exchange (ETDEWEB)

    Nakanishi, T.; Aoyagi, H.; Nakamura, S.; Okumi, S.; Suzuki, C.; Takahashi, C.; Tanimoto, Y.; Tawada, M.; Togawa, K.; Tsubata, M. [Department of Physics, Nagoya University, Nagoya 464 (Japan); Kurihara, Y.; Omori, T.; Takeuchi, Y.; Yoshioka, M. [KEK, National Laboratory for High Energy Physics, Tsukuba 305 (Japan); Kato, T.; Saka, T. [New Research Laboratory, Daido Steel Co. Ltd., Nagoya 457 (Japan); Baba, T.; Mizuta, M. [Fundamental Research Laboratory, NEC Corp., Tsukuba 305 (Japan)

    1995-09-01

    Recently the high electron spin polarization (ESP) photocathodes which have also high quantum efficiencies (QE) have been developed in Japan. These improvements were achieved using new techniques of a resonant absorption and a modulated doping, which are applied to a strained GaAs grown on GaAsP and an AlGaAs-GaAs superlattice, respectively. The former photocathode provides the QE of 1.0{percent} with the ESP of 85{percent} at the laser wavelength of 866 nm. The latter one does the QE of 0.5{percent} with the ESP of 71{percent} at 757 nm. Using a new type of strained-layer superlattice cathode, the ESP of 83{percent} which is higher than that of our previous superlattices was observed. The development of photocathodes not only with a high ESP but also with a high QE are discussed. {copyright} {ital 1995 American Institute of Physics.}

  8. The Nagoya cosmic-ray muon spectrometer 3, part 1: Preliminary observations

    Science.gov (United States)

    Kamiya, Y.; Shibata, S.; Iijima, K.; Iida, S.

    1985-01-01

    There are some discrepancies among the data of absolute muon intensities at large zenth angles. Through the analysis of the data obtained in the previous measurement by Nagoya Cosmic Ray Spectrometer, one of the sources of these discrepancies has been found to be the ambiguity induced by the selection criteria with which genuine muons are distinguished from the backgrounds. To remove the ambiguity of this kind, it is necessary to know the amount of the backgrounds and their characteristics in detail. Some features of the background events were reported from the observations by using this triggering system of Nagoya Cosmic Ray Spectrometer. In this paper, the results of extended observations using track detector together with this system are reported.

  9. Explanation of the Nagoya Protocol on Access and Benefit Sharing and its implication for microbiology.

    Science.gov (United States)

    Smith, David; da Silva, Manuela; Jackson, Julian; Lyal, Christopher

    2017-03-01

    Working with genetic resources and associated data requires greater attention since the Nagoya Protocol on Access and Benefit Sharing (ABS) came into force in October 2014. Biologists must ensure that they have legal clarity in how they can and cannot use the genetic resources on which they carry out research. Not only must they work within the spirit in the Convention on Biological Diversity (https://www.cbd.int/convention/articles/default.shtml?a=cbd-02) but also they may have regulatory requirements to meet. Although the Nagoya Protocol was negotiated and agreed globally, it is the responsibility of each country that ratifies it to introduce their individual implementing procedures and practices. Many countries in Europe, such as the UK, have chosen not to put access controls in place at this time, but others already have laws enacted providing ABS measures under the Convention on Biological Diversity or specifically to implement the Nagoya Protocol. Access legislation is in place in many countries and information on this can be found at the ABS Clearing House (https://absch.cbd.int/). For example, Brazil, although not a Party to the Nagoya Protocol at the time of writing, has Law 13.123 which entered into force on 17 November 2015, regulated by Decree 8.772 which was published on 11 May 2016. In this case, export of Brazilian genetic resources is not allowed unless the collector is registered in the National System for Genetic Heritage and Associated Traditional Knowledge Management (SisGen). The process entails that a foreign scientist must first of all be registered working with someone in Brazil and have authorization to collect. The enactment of European Union Regulation po. 511/2014 implements Nagoya Protocol elements that govern compliance measures for users and offers the opportunity to demonstrate due diligence in sourcing their organisms by selecting from holdings of 'registered collections'. The UK has introduced a Statutory Instrument that puts in

  10. [Tuberculosis statistics among the homeless population in Nagoya City from 1991 to 1995].

    Science.gov (United States)

    Yamanaka, K; Akashi, T; Miyao, M; Ishihara, S

    1998-06-01

    A survey was conducted to clarify the tuberculosis (TB) situation among the homeless during the period from 1991 to 1995 in Nagoya city, using 5,222 registration cards of TB cases registered at one of Nagoya City's 16 Health Centers. Out of 5,222 TB cases, there were 269 homeless cases (267 male and 2 female). Ninety-seven percent of them were pulmonary TB cases. The incidence and prevalence rates of TB per 100,000 among the homeless were estimated at around 1,500 and around 2,400, respectively, around 20 times higher than those of the non-homeless male over the 19 years of age. A decrease in the incidence rate of TB cases among the homeless was not seen, although the rate among the non-homeless decreased gradually. The percentage of infectious (bacillary and/or cavitary) tuberculous cases among the homeless was higher than in the non-homeless. In the infectious cases, the percentage of smear-positive bacillary cases or far advanced cavitary cases was 52.1% or 9.4% among the homeless compared to 48.1% or 2.6% among the non-homeless, respectively. The detection rate by chest X-ray examination of the homeless was 3.9%.

  11. Bridging the Nagoya Compliance Gap: The Fundamental Role of Customary Law in Protection of Indigenous Peoples’ Resource and Knowledge Rights

    Directory of Open Access Journals (Sweden)

    Brendan M. Tobin

    2013-09-01

    Full Text Available The Nagoya Protocol requires states to ensure that access to and use of genetic resources and traditional knowledge of Indigenous peoples and local communities is subject to their prior informed consent (PIC. It also requires states to take into consideration their customary laws. However, it lacks effective compliance mechanisms, a gap exposed in draft European legislation that sidesteps the Nagoya Protocol’s obligations regarding PIC and customary law, leaving traditional knowledge largely unprotected. This article examines the status of customary law under international, regional and national law, and the challenges and opportunities for securing recognition of its role in the protection of traditional knowledge. The article contends that all commercial and development activities with the potential to impact on Nagoya Protocol rights will in the future need to ensure compliance with relevant customary law. It finds state reluctance to adopt measures to ensure consideration of customary law shortsighted and likely to lead to increased litigation. It concludes that customary law has a key role to play in closing the Nagoya compliance gap but to do so it will need to be supported by enforcement mechanisms such as disclosure of origin regimes in intellectual property law.

  12. Possible consequences of the Nagoya Protocol for animal breeding and the worldwide exchange of animal genetic resources

    NARCIS (Netherlands)

    Martyniuk, E.; Berger, B.; Bojkovski, D.; Bouchel, D.; Hiemstra, S.J.; Marguerat, C.; Matlova, V.; Sæther, N.

    2018-01-01

    The paper discusses animal genetic resources in the context of the Nagoya Protocol, providing an overview of the distinctive features and practices in this sector of genetic resources. It presents how animal genetic resources are utilized, who are the users and providers, and what are the trends in

  13. The U.S. Culture Collection Network Responding to the Requirements of the Nagoya Protocol on Access and Benefit Sharing

    Science.gov (United States)

    Kevin McCluskey; Katharine B. Barker; Hazel A. Barton; Kyria Boundy-Mills; Daniel R. Brown; Jonathan A. Coddington; Kevin Cook; Philippe Desmeth; David Geiser; Jessie A. Glaeser; Stephanie Greene; Seogchan Kang; Michael W. Lomas; Ulrich Melcher; Scott E. Miller; David R. Nobles; Kristina J. Owens; Jerome H. Reichman; Manuela da Silva; John Wertz; Cale Whitworth; David Smith; Steven E. Lindow

    2017-01-01

    The U.S. Culture Collection Network held a meeting to share information about how culture collections are responding to the requirements of the recently enacted Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity (CBD). The meeting included representatives...

  14. The US Culture Collection Network responding to the requirements of the Nagoya Protocol on Access and Benefit Sharing

    Science.gov (United States)

    The US Culture Collection Network held a meeting to share information about how collections are responding to the requirements of the recently enacted Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Bio...

  15. The Nagoya cosmic-ray muon spectrometer 3, part 4: Track reconstruction method

    Science.gov (United States)

    Shibata, S.; Kamiya, Y.; Iijima, K.; Iida, S.

    1985-01-01

    One of the greatest problems in measuring particle trajectories with an optical or visual detector system, is the reconstruction of trajectories in real space from their recorded images. In the Nagoya cosmic-ray muon spectrometer, muon tracks are detected by wide gap spark chambers and their images are recorded on the photographic film through an optical system of 10 mirrors and two cameras. For the spatial reconstruction, 42 parameters of the optical system should be known to determine the configuration of this system. It is almost impossible to measure this many parameters directly with usual techniques. In order to solve this problem, the inverse transformation method was applied. In this method, all the optical parameters are determined from the locations of fiducial marks in real space and the locations of their images on the photographic film by the non-linear least square fitting.

  16. Understanding Chemotherapy

    Science.gov (United States)

    ... is a cancer treatment that uses drugs to destroy cancer cells. It is also called “chemo.” Today, there are ... help me? Chemotherapy can be used to: l Destroy cancer cells l Stop cancer cells from spreading l Slow ...

  17. EMC '89 - International Symposium on Electromagnetic Compatibility, Nagoya, Japan, Sept. 8-10, 1989, Proceedings. Vols. 1 & 2

    Science.gov (United States)

    The present conference discusses such fields of EM compatibility as EM wave propagation, EMI, seismoelectromagnetism, EMC testing methods, EM in power lines, EM standards and regulations, EM bioeffects, EMC in amateur radio operations, EM coupling, lightning and EMP, shielding and grounding, EM scattering, and EM filtering. Also discussed are EMC in spead-spectrum systems, EM noise filters, EM absorbers, and EM shielding and grounding.

  18. RESEARCH INTO EVALUATIONS OF UNDERGROUND SPACE ACCORDING TO QOL - CENTERING ON THE NAGOYA UNDERGROUND METRO -

    Science.gov (United States)

    Yoshimoto, Naomi; Wake, Tenji; Mita, Takeshi; Wake, Hiromi

    The present research investigates issues concerning space underground and concerns itself with psychological evaluations of comfort in underground railway premises from the perspective of the users of such premises. The actual psychological evaluation was done on the premises of nine Nagoya City underground stations. Four factors were extracted from the results obtained. The first factor is transmission information, the second factor is the comfort of the environment, the third is sense of insecurity, and the fourth, convenience. A covariance structure analysis was carried out to see if there was any relationship between these factors and the research participants' age and frequency of underground usage. It was found from this that the first element is related to the frequency with which the participants in the research use the underground trains. When the frequency of use is high, transmission of information is high. A relationship was also found between aging and factors one and four. The older the person the worse information transmission is and the more dependent they are on convenience, such as, for example, in terms of elevators and escalators.

  19. Changing values of farm animal genomic resources. from historical breeds to the Nagoya Protocol.

    Science.gov (United States)

    Tamminen, Sakari

    2015-01-01

    The paper reviews the history of Animal genetic resources (AnGRs) and claims that over the course of history they have been conceptually transformed from economic, ecologic and scientific life forms into political objects, reflecting in the way in which any valuation of AnGRs is today inherently imbued with national politics and its values enacted by legally binding global conventions. Historically, the first calls to conservation were based on the economic, ecological and scientific values of the AnGR. While the historical arguments are valid and still commonly proposed values for conservation, the AnGR have become highly politicized since the adoption of the Convention of Biological Diversity (CBD), the subsequent Interlaken Declaration, the Global Plan for Action (GPA) and the Nagoya Protocol. The scientific and political definitions of the AnGRs were creatively reshuffled within these documents and the key criteria by which they are now identified and valued today were essentially redefined. The criteria of "in situ condition" has become the necessary starting point for all valuation efforts of AnGRs, effectively transforming their previous nature as natural property and global genetic commons into objects of national concern pertaining to territorially discrete national genetic landscapes, regulated by the sovereign powers of the parties to the global conventions.

  20. Preliminary Results of the Investigation of the Carbonaceous Chondrites Nagoya, Allende, and Murray

    Science.gov (United States)

    Rozanov, Alexei Yu.; Hoover, Richard B.; Rose, M. Franklin (Technical Monitor)

    2000-01-01

    As part of a long-term study of morphological biomarkers in Astromaterials, we are documenting a variety of features considered to be indigenous to ancient terrestrial rocks and carbonaceous meteorites. In preparation for the study of samples returned from Mars and other bodies of our Solar System, it is imperative that we establish a database of the nature and morphology of known bacterial fossils in Earth rocks and biomorphic microstructures which may represent microfossils in meteorites. The process of fossilization or mineralization can cause major changes in morphologies and textures of the original organisms and the study of fossilized terrestrial organisms can help provide insight into the interpretation of mineral biomarkers and abiotic microstructures which may mimic certain aspects of microfossils. One class of biomarkers consists of biominerals which have either been precipitated directly by microorganisms, or whose precipitation has been influenced by the organisms. Such microbe-mediated mineral formation may include important clues to the size, shape, and environment of the microorganisms. This paper describes the detection of possible microbe-mediated minerals, biomorphic microstructures and possible microfossils in the Nagoya, Allende, and Murray Carbonaceous Chondrites.

  1. The Nagoya cosmic-ray muon spectrometer 3, part 2: Track detector

    Science.gov (United States)

    Shibata, S.; Iijima, K.; Kamiya, Y.; Iida, S.

    1985-01-01

    The twelve wide gap spark chambers were utilized as the track detectors of the Nagoya cosmic-ray muon spectrometer not only to obtain the precise locations of particles, but also to get some information about the correspondences between segments of trajectories. The area of each chamber is 150 x 70 sq cm and the width of a gap is 5 cm. The gas used is He at the atmospheric pressure. Each three pairs of them are placed on both sides of the deflection magnet. All images of sparks for each event are projected through the mirror system and recorded by two cameras stereoscopically. The mean detection efficiency of each chamber is 95 + or - 2% and the spacial resolution (jitter and drift) obtained from the prototype-experiment is 0.12 mm. Maximum detectable momentum of the spectrometer is estimated at about 10 TeV/c taking into account these characteristics together with the effects of the energy loss and multiple Coulomb scattering of muons in the iron magnet.

  2. Traditional Knowledge and Benefit Sharing After the Nagoya Protocol: Three Cases from South Africa

    Directory of Open Access Journals (Sweden)

    Roger Chennells

    2013-09-01

    Full Text Available The Nagoya Protocol of the Convention on Biological Diversity (CBD has finally produced a negotiated framework intended to significantly advance the achievement of its core objectives, chief amongst them benefit sharing with indigenous and local communities who are holders of traditional knowledge related to genetic resources. The interpretation, in particular of central concepts contained in the Protocol, namely traditional knowledge (TK, community, and ownership of TK, and the practical application thereof by governments, are key to the success of the emerging access and benefit sharing regime. This article examines the manner in which the South African Biodiversity Act deals with these concepts. Three recent case studies are described, namely the Hoodia, Sceletium and Pelargonium cases, in which a range of issues relating to holders of TK were resolved, including the question of who the indigenous knowledge holders are. Moreover the debate on the question as to whether the intellectual property rights of TK holders are property rights as such, leads to the author’s suggestion that TK rights are a sui generis form of property rights, and that the legal principles contained in the law of equity provide useful and accessible guidance towards resolution of potentially competing claims of TK rights by indigenous peoples.

  3. Changing values of Farm Animal Genomic Resources. From historical breeds to the Nagoya Protocol.

    Directory of Open Access Journals (Sweden)

    Sakari eTamminen

    2015-09-01

    Full Text Available The paper reviews the history of AnGRs and claims that over the course of history they have been conceptually transformed from economic, ecologic and scientific life forms into political objects, reflecting in the way in which any valuation of AnGRs is today inherently imbued with national politics and its values enacted by legally binding global conventions. Historically, the first calls to conservation were based on the economic, ecological and scientific values of the AnGR. While the historical arguments are valid and still commonly proposed values for conservation, the AnGR have become highly politicized since the adoption of the Convention of Biological Diversity (CBD, the subsequent Interlaken Declaration, the Global Plan for Action (GPA and the Nagoya Protocol. The scientific and political definitions of the AnGRs were creatively reshuffled within these documents and the key criteria by which they are now identified and valued today were essentially redefined. The criteria of in-situ condition has become the necessary starting point for all valuation efforts of AnGRs, effectively transforming their previous nature as natural property and global genetic club commons into objects of national concern pertaining to territorially discrete national genetic landscapes, regulated by the sovereign powers of the parties to the global conventions.

  4. Status of treatment for the overall population of patients with stage IVb endometrial cancer, and evaluation of the role of preoperative chemotherapy: a retrospective multi-institutional study of 426 patients in Japan.

    Science.gov (United States)

    Eto, Takako; Saito, Toshiaki; Shimokawa, Mototsugu; Hatae, Masayuki; Takeshima, Nobuhiro; Kobayashi, Hiroaki; Kasamatsu, Takahiro; Yoshikawa, Hiroyuki; Kamura, Toshiharu; Konishi, Ikuo

    2013-12-01

    We previously reported on the role of cytoreduction in 248 patients with surgical stage IVb endometrial cancer (EMCA). This study aimed to evaluate the clinical characteristics, prognosis according to initial treatment, and impact of preoperative chemotherapy in the overall population of patients with clinical and surgical stage IVb EMCA. A multi-institutional retrospective analysis was performed in 426 patients diagnosed with clinical and surgical stage IVb EMCA from 1996 to 2005. Factors associated with overall survival (OS) were identified using univariate and multivariate analyses. The median OS for all 426 patients was 14 months. Patients were divided into three groups according to their initial treatment: primary surgery group (n=279), primary chemotherapy group (n=125), and palliative care group (n=22). The median OS times for these groups were 21, 12, and 1 month, respectively (p<0.0001). Patients in the primary surgery group had better performance status (PS) and lower numbers of extra-abdominal metastases than those in the primary chemotherapy group. Multivariate analysis identified good PS, endometrioid histology, absence of clinical intra-abdominal stage IVb metastasis, hysterectomy, and chemotherapy as independent predictors of OS. In the primary chemotherapy group, 59 patients subsequently underwent surgery, and these patients had similar OS to those in the primary surgery group. Hysterectomy and chemotherapy may prolong OS in selected patients with stage IVb EMCA. Our data suggest that primary chemotherapy followed by surgery may be a useful treatment choice in patients not suitable for primary surgery. © 2013.

  5. Japan 2003

    DEFF Research Database (Denmark)

    Ørstrup, Finn Rude; Hvass, Sven

    2003-01-01

    Kompendium udarbejdet til en studierejse til Japan  2003 Kunstakademiets Arkitektskole, Studieafdeling 10......Kompendium udarbejdet til en studierejse til Japan  2003 Kunstakademiets Arkitektskole, Studieafdeling 10...

  6. HIV chemotherapy

    Science.gov (United States)

    Richman, Douglas D.

    2001-04-01

    The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV) has transformed the face of AIDS in the developed world. Pronounced reductions in illness and death have been achieved and healthcare utilization has diminished. HIV therapy has also provided many new insights into the pathogenesis and the viral and cellular dynamics of HIV infection. But challenges remain. Treatment does not suppress HIV replication in all patients, and the emergence of drug-resistant virus hinders subsequent treatment. Chronic therapy can also result in toxicity. These challenges prompt the search for new drugs and new therapeutic strategies to control chronic viral replication.

  7. chemotherapy patients

    Directory of Open Access Journals (Sweden)

    Katarzyna Augustyniuk

    2016-02-01

    Full Text Available Background . Complementary and alternative medicine (CAM practices for cancer have become popular among oncology patients. An increasing interest in alternative medicine can be explained by the inefficiency of conventional treatment, dissatisfaction with treating patients like objects, and the will to use all available treatment methods. Objectives . The authors assessed how often patients use CAM methods, and which of them are most popular. Material and methods . The study was conducted in Military Hospital no. 109 and the Independent Public Clinical Hospital no. 1 in Szczecin among 100 chemotherapy patients. This survey-based study was performed using an original questionnaire. Results. Most respondents (68% did not use alternative methods to fight the disease. The most popular treatment methods were: herbal medicine (50%, alternative medicine preparations (38% and diet (25%, and the least common: hypnosis (3% and aromatherapy (3%. Analyzed sociodemographic factors had no effects on a choice of a CAM method. Patients obtained information about CAM methods mainly from the Internet (40%, medical staff (37% and literature (31%. Conclusions . 1. Using CAM by patients receiving chemotherapy for neoplasms is quite a common phenomenon. 2. CAM were more often chosen by women. Neither the duration of the disease nor sociodemographic data had effects on making the decision to use CAM methods. 3. The most popular CAM were: herbal medicine, alternative medicine preparations, and diet. 4. Cancer patients should receive special support from nurses and doctors as well as other members of the therapeutic team. Oncology patients should never be left on their own so that they were forced to seek help and support in therapies unconfirmed by scientific investigation.

  8. The U.S. Culture Collection Network Responding to the Requirements of the Nagoya Protocol on Access and Benefit Sharing.

    Science.gov (United States)

    McCluskey, Kevin; Barker, Katharine B; Barton, Hazel A; Boundy-Mills, Kyria; Brown, Daniel R; Coddington, Jonathan A; Cook, Kevin; Desmeth, Philippe; Geiser, David; Glaeser, Jessie A; Greene, Stephanie; Kang, Seogchan; Lomas, Michael W; Melcher, Ulrich; Miller, Scott E; Nobles, David R; Owens, Kristina J; Reichman, Jerome H; da Silva, Manuela; Wertz, John; Whitworth, Cale; Smith, David

    2017-08-15

    The U.S. Culture Collection Network held a meeting to share information about how culture collections are responding to the requirements of the recently enacted Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity (CBD). The meeting included representatives of many culture collections and other biological collections, the U.S. Department of State, U.S. Department of Agriculture, Secretariat of the CBD, interested scientific societies, and collection groups, including Scientific Collections International and the Global Genome Biodiversity Network. The participants learned about the policies of the United States and other countries regarding access to genetic resources, the definition of genetic resources, and the status of historical materials and genetic sequence information. Key topics included what constitutes access and how the CBD Access and Benefit-Sharing Clearing-House can help guide researchers through the process of obtaining Prior Informed Consent on Mutually Agreed Terms. U.S. scientists and their international collaborators are required to follow the regulations of other countries when working with microbes originally isolated outside the United States, and the local regulations required by the Nagoya Protocol vary by the country of origin of the genetic resource. Managers of diverse living collections in the United States described their holdings and their efforts to provide access to genetic resources. This meeting laid the foundation for cooperation in establishing a set of standard operating procedures for U.S. and international culture collections in response to the Nagoya Protocol.

  9. The U.S. Culture Collection Network Responding to the Requirements of the Nagoya Protocol on Access and Benefit Sharing

    Directory of Open Access Journals (Sweden)

    Kevin McCluskey

    2017-08-01

    Full Text Available The U.S. Culture Collection Network held a meeting to share information about how culture collections are responding to the requirements of the recently enacted Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity (CBD. The meeting included representatives of many culture collections and other biological collections, the U.S. Department of State, U.S. Department of Agriculture, Secretariat of the CBD, interested scientific societies, and collection groups, including Scientific Collections International and the Global Genome Biodiversity Network. The participants learned about the policies of the United States and other countries regarding access to genetic resources, the definition of genetic resources, and the status of historical materials and genetic sequence information. Key topics included what constitutes access and how the CBD Access and Benefit-Sharing Clearing-House can help guide researchers through the process of obtaining Prior Informed Consent on Mutually Agreed Terms. U.S. scientists and their international collaborators are required to follow the regulations of other countries when working with microbes originally isolated outside the United States, and the local regulations required by the Nagoya Protocol vary by the country of origin of the genetic resource. Managers of diverse living collections in the United States described their holdings and their efforts to provide access to genetic resources. This meeting laid the foundation for cooperation in establishing a set of standard operating procedures for U.S. and international culture collections in response to the Nagoya Protocol.

  10. KONSEP AMALGAMATION SEBAGAI SUATU PENYESUAIAN DALAM PENATAAN BANGUNAN DAN LINGKUNGAN DI KAWASAN NAGOYA BATAM, PROVINSI KEPULAUAN RIAU

    Directory of Open Access Journals (Sweden)

    Ashri Prawesthi

    2015-07-01

    This concept can be applied in Nagoya Square which is as an are for international trading and services but has poor condition of old buildings. Through this way, we can create breathing spaces like a pocket park between densely packed buildings, or pedestrianise a road to become and create new public spaces that all can enjoy. This paper tells about the concept itself and the result how a new lease of life happen. Several shophouses can combine to become one property, with a new block built behind. The old shophouse row is modeled to an old-new development, with double the space it used to provide. Keywords: Amalgamation, join small, bigger plots

  11. Cancer Chemotherapy - Multiple Languages

    Science.gov (United States)

    ... Expand Section Cancer Chemotherapy - 简体中文 (Chinese, Simplified (Mandarin dialect)) Bilingual PDF Health Information Translations Handling Chemotherapy Safely - 简体中文 (Chinese, Simplified (Mandarin dialect)) ...

  12. Types of chemotherapy

    Science.gov (United States)

    ... medicine to treat cancer. Standard chemotherapy works by killing cancer cells and some normal cells. Targeted treatment ... of control. They keep growing to form a mass of cells, or tumor. Chemotherapy attacks dividing cells. ...

  13. Proceedings on US-Japan workshop A-56 'irradiation effects on plasma diagnostic equipment'

    International Nuclear Information System (INIS)

    1986-06-01

    This is a collection of abstracts and papers for the US-Japan Workshop A-56 on ''Irradiation Effects on Plasma Diagnostic Equipments'' held at the Institute of Plasma Physics, Nagoya University, on January 28 through 30, 1986. The topics presented at the workshop are classified as follows: 1) Definition of the problems and general views. 2) Radiation levels estimated from recent experiments and analysis on large tokamaks. 3) Radiation sensitivities of diagnostic components. 4) Neutron sources for irradiation testing. 5) Discussion on suggested experiments on radiation hardening and conclusions. The conclusions summarized by Dr. K. M. Young are also included. (author)

  14. Networking Japan

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    and activities in Japan. One concrete example was the earthquake relief Japan received from alumni in 2011. The exchanges have also already inspired an explicit focus on private sector and middle income countries in the Japanese Development Cooperation Charter announced in February 2015.......Human Resource Development was the first and remains an important pillar in Japanese foreign aid. I will argue that Japan has access to a global network of alumni who will co-define Japanese foreign aid in the future, because Japan has encouraged alumni societies and networking since 1965. A total...... of more than a million people in more than 100 countries have attended courses in Japan funded fully or partly by Japanese ODA since the inception of the technical assistance programs in 1954 through the Colombo Plan and since 1959 through the Association of Overseas Technical Scholarships (AOTS from 2009...

  15. The Economics of Information, Studiously Ignored in the Nagoya Protocol on Access to Genetic Resources and Benefit Sharing

    Directory of Open Access Journals (Sweden)

    Joseph Henry Vogel et. al.

    2011-06-01

    Full Text Available The economics of information has been studiously ignored in the ten Conferences of the Parties to the Convention on Biological Diversity. Nevertheless, an academic literature exists which recognises genetic resources and associated traditional knowledge as natural and artificial information. Its unambiguous prescriptions would widen the scope of the Nagoya Protocol on Access to Genetic Resources and Benefit Sharing (ABS and resolve almost all of the contentious issues identified by Kamau et al. One begins with retroactivity: because biological resources exhibit tangible and intangible aspects, the latter can be conceptualised as a set of natural information where value currently added in a patent is access to a subset not previously accessed. The economics quickly leads to a justification for a biodiversity cartel among countries of origin, wholly analogous to monopoly intellectual property rights. To achieve such a sea change in policymaking, the justification must be accompanied by a narrative that can penetrate the social sphere, much as Trade Related Intellectual Property Rights achieved through the World Intellectual Property Organisation. Several examples of bio-discoveries drawn from a popular medium are analysed in terms of the contentious issues of the Protocol and the distinct ABS that would eventuate under cartelisation. History also offers an analogy. The Parties’ eighteen years of resistance (1993-2011 to applying the economics of information to genetic resources is reminiscent to the twenty-seven years that the British Parliament rebuffed David Ricardo’s economic analysis of the Corn Laws (1815-1842.

  16. Chemotherapy in eye cancer

    African Journals Online (AJOL)

    Chemotherapy in eye cancer. Chemotherapy is one of several treatment strategies used to halt the uncontrolled division, proliferation and unpredictable growth patterns of malignant cells. R Dolland, BSc, MB BCh, FC Ophth (SA). Consultant, St John Eye Hospital, Division of Ophthalmology, Department of Neurosciences, ...

  17. Postoperative Chemotherapy for Medulloblastoma

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2005-03-01

    Full Text Available The survival rate and cognitive function of 43 children, age <3 years, with medulloblastoma treated with intensive postoperative chemotherapy alone, without radiotherapy, were determined at the University of Wurzburg and other centers in Germany Chemotherapy consisted of three two-month cycles of cyclophosphamide, methotrexate, vincristine, carboplatin, and etoposide.

  18. Japan 2014

    DEFF Research Database (Denmark)

    Selmer, Finn

    2014-01-01

    In March 2014 a group of teachers and students from the Royal Danish Academy of Fine Arts Schools of Architecture, Design and Conservation, School of Architecture, Study Dept. 3 went on a study trip to Japan. This publication collects observations and reflections that the participants of the trip...

  19. After chemotherapy - discharge

    Science.gov (United States)

    ... Leukemia Acute Myeloid Leukemia Adrenal Gland Cancer Anal Cancer Bladder Cancer Bone Cancer Brain Tumors Breast Cancer Cancer Chemotherapy ... used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed ...

  20. Report on the meetings of the International Organization for Crystal Growth Executive Council and General Assembly held during ICCGE-18 in Nagoya (Japan) August 7-12, 2016

    Science.gov (United States)

    Dabkowska, Hanna A.

    2017-06-01

    The International Organization for Crystal Growth (IOCG) Executive Committee, Council and General Assembly met in the week 7-12 August 2016. Participation quorum was achieved at all the meetings. The following changes in the Constitution, already approved at ICCGE-17 for the second time, were moved to be presented to the IOCG General Assembly for the third and final approval. 7.a The International Conference on Crystal Growth, ICCG is renamed to the International Conference on Crystal Growth and Epitaxy (ICCGE) and all references to ICCG in the constitution and By-laws are changed to ICCGE. 7.b The IOCG Constitution is amended such that Article III Section 1 will read as "The Executive Committee shall consist of the five Officers, the Past President, the Chairman or Chairmen of the past ICCGE the Chairman or Chairmen of the next ICCGE and up to ten additional members elected by the Council." 7.c The IOCG Constitution is amended such that Article IV Section 1 includes the sentence: "The Council may also include ex-officio members as described in the Bylaws" There was no change to the Bylaws. All provisional amendments are included in the IOCG Constitution and Bylaws with different text colors. The amendments that were approved for the third time and are definitive are inserted with no special color as part of standard text.

  1. Okinawa, Japan

    Science.gov (United States)

    1991-01-01

    The southern half of the island of Okinawa, Japan (26.5N, 128.0E) can be seen in this nearly cloud free view. Okinawa is part of the Ryuku Islands which extend from Taiwan northeastward to Kyushu, southernmost of the Japanese Home Islands. The large military base at Kadena, with large runways, is visible near the center of the scene. Kadena is one of several emergency landing sites around the world for the space shuttle.

  2. Three distinct point mutations in the factor IX gene of three Japanese CRM+ hemophilia B patients (factor IX BMNagoya 2, factor IX Nagoya 3 and 4).

    Science.gov (United States)

    Hamaguchi, M; Matsushita, T; Tanimoto, M; Takahashi, I; Yamamoto, K; Sugiura, I; Takamatsu, J; Ogata, K; Kamiya, T; Saito, H

    1991-05-06

    Enzymatic DNA amplification and complete sequence analysis were used to investigate human factor IX coding sequences in three CRM+ hemophilia B patients. In a patient with severe hemophilia B and a markedly prolonged ox-brain prothrombin time, a C to T transition in exon VI changed the codon for Arg180 to Trp (factor IX BMNagoya 2). This mutation would impair the cleavage by factor XIa required for activation of the zymogen. In a patient with mild hemophilia B, a G to A transition in exon VI changed the codon for Arg145 to His(factor IX Nagoya 3). This substitution also would be predicted to preclude the cleavage of factor IX by factor XIa at this peptide bond (Arg145-Ala146). Furthermore, this point mutation creates a new NlaIII restriction site which provides a quick and reliable method for carrier detection in the affected family members. A patient with severe hemophilia B (factor IX Nagoya 4) had a G to A transition in exon II changing the codon for Glu21 to Lys. This novel point mutation is assumed to impair the function of factor IX by disrupting the calcium binding of factor IX.

  3. Daptomycin approved in Japan for the treatment of methicillin-resistant Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Mori T

    2012-02-01

    Full Text Available Mao Hagihara1, Takumi Umemura1, Takeshi Mori1,2, Hiroshige Mikamo11Department of Infection Control and Prevention, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 2Division of Pharmaceutical Science, Faculty of Pharmacy, Meijo University, Nagoya, Aichi, JapanAbstract: Daptomycin is a lipoglycopeptide antibacterial drug that is rapidly bactericidal for methicillin-resistant Staphylococcus aureus (MRSA infection and has antibiotic activity against a wide range of Gram-positive organisms. It has been approved by the Ministry of Health, Labor and Welfare in Japan for the treatment for bacteremia, right-sided endocarditis, and skin and skin-structure infections, such as necrotizing fasciitis, due to MRSA on the basis of a Phase III trial conducted in Japan since July, 2011. In Japanese Phase I and III trials, daptomycin therapy given at 4 mg/kg and 6 mg/kg once per day was well tolerated and effective as standard therapy for the treatment of acute bacterial skin and skin-structure infections and bacteremia caused by MRSA, but side effects remain to be evaluated in large-scale trials.Keywords: daptomycin, methicillin-resistant Staphylococcus aureus (MRSA, Japan

  4. Hyperthermia and chemotherapy agent

    International Nuclear Information System (INIS)

    Roizin-Towle, L.; Hall, E.J.

    1981-01-01

    The use of chemotherapeutic agents for the treatment of cancer dates back to the late 19th century, but the modern era of chemotherapy drugs was ushered in during the 1940's with the development of the polyfunctional alkylating agent. Since then, numerous classes of drugs have evolved and the combined use of antineoplastic agents with other treatment modalities such as radiation or heat, remains a large relatively unexplored area. This approach, combining local hyperthermia with chemotherapy agents affords a measure of targeting and selective toxicity not previously available for drugs. In this paper, the effects of adriamycin, bleomycin and cis-platinum are examined. The adjuvant use of heat may also reverse the resistance of hypoxic cells noted for some chemotherapy agents

  5. Combination Chemotherapy for Influenza

    Directory of Open Access Journals (Sweden)

    Robert G. Webster

    2010-07-01

    Full Text Available The emergence of pandemic H1N1 influenza viruses in April 2009 and the continuous evolution of highly pathogenic H5N1 influenza viruses underscore the urgency of novel approaches to chemotherapy for human influenza infection. Anti-influenza drugs are currently limited to the neuraminidase inhibitors (oseltamivir and zanamivir and to M2 ion channel blockers (amantadine and rimantadine, although resistance to the latter class develops rapidly. Potential targets for the development of new anti-influenza agents include the viral polymerase (and endonuclease, the hemagglutinin, and the non-structural protein NS1. The limitations of monotherapy and the emergence of drug-resistant variants make combination chemotherapy the logical therapeutic option. Here we review the experimental data on combination chemotherapy with currently available agents and the development of new agents and therapy targets.

  6. Chemotherapy in thyroid carcinoma

    International Nuclear Information System (INIS)

    Samuel, A.M.; Shah, D.H.

    1999-01-01

    Chemotherapy alone, either as a single drug or a combination of drugs with or without external radiation (ER) is useful for treatment of locally advanced disease and non iodine concentrating metastasis in differentiated thyroid cancers (DTC). The reported response is not encouraging, but the absence of better alternatives leave no choice for the treatment of such cases. However, for treatment of anaplastic thyroid cancers (ANC), chemotherapy (CT) in combination with ER results in local control. In medullary thyroid cancers (MTC), the results obtained with multimodal treatment are encouraging

  7. Hokkaido, Japan

    Science.gov (United States)

    2006-01-01

    Cities mingle with rugged hills and a dormant volcano in this image of Hokkaido, Japan. This three-dimensional image comes from observations made by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite on July 23, 2006. The view is toward the north and slightly east. Green indicates vegetation; beige and gray indicate bare ground, paved surfaces, or buildings; and dark blue indicates water. The water body at the top of the image is the Pacific Ocean. Now dormant, Mount Yotei is a stratovolcano--a symmetrical cone composed of alternating layers of hardened lava, solidified ash, and volcanic rocks ejected in previous eruptions. It reaches a height of 1,898 meters (6,227 feet), and its summit sports a 700-meter- (2,297-foot-) wide crater. Snow often caps this volcano, but in this summertime shot, the volcano's summit is snow-free. The volcano is also known as Ezo-Fuji for its resemblance to Mount Fuji. As angular patches of gray and beige indicate, urban areas surround the volcano, most notably the city of Kutchan to the northwest. Even when volcanoes remain active, people often settle close to them, drawn by benefits of good soil and mild climates that appear to outweigh the risks. NASA image by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  8. Wind Energy Japan

    Energy Technology Data Exchange (ETDEWEB)

    Komatsubara, Kazuyo [Embassy of the Kingdom of the Netherlands, Tokyo (Japan)

    2012-06-15

    An overview is given of wind energy in Japan: Background; Wind Energy in Japan; Japanese Wind Energy Industry; Government Supports; Useful Links; Major Japanese Companies; Profiles of Major Japanese Companies; Major Wind Energy Projects in Japan.

  9. Transformative possibilities of communication in medical error cases in Japan.

    Science.gov (United States)

    Okamoto, Sawako; Kawahara, Kazuo; Algren, Margaret

    2011-02-01

    This study examines perceptions of persons who experienced a medical error and elements that may serve to open communication with those who experienced a medical error in Japan. Survey of individuals who reported a previous medical error in their care and those who did not. Tokyo, Osaka and Nagoya metropolitan areas, and in Fukuoka, Shimane and Miyagi rural townships in Japan. Questionnaires were distributed to 80 people who had experienced a medical error and 300 people who had not. Prevalence of views, expectations and psychological needs regarding medical error. Forty (50%) questionnaires from those who experienced the errors and 201 (67%) from those who did not experience a medical error were completed. Among those who experienced error, 95% (38/40) preferred to be informed of a medical error immediately by senior personnel (57.7%: 23/40). Those who had not experienced error preferred to be informed by a directly responsible provider (87.6%: 176/201). The perception differences regarding who should break bad news showed statistical significance (Pmedical error by senior medical personnel and medical providers should create an environment to continue 'communication' in order to accommodate shifting perspectives of those who experienced the error.

  10. Chemotherapy in Glioma

    NARCIS (Netherlands)

    W. Taal (Walter)

    2015-01-01

    markdownabstractGliomas are primary brain tumors and include astrocytomas, oligodendrogliomas, and mixed oligo-astrocytomas. Currently, treatment of newly diagnosed diffuse adult gliomas exists of surgery, radiotherapy and chemotherapy. We were the first to show a high incidence of progressive MRI

  11. JAPAN'S TECHNOLOGY TRADE

    OpenAIRE

    Hagiwara, Taiji

    1994-01-01

    Japan's technology balance of trade has improved over the last twenty years. The position of Japan is examined through (1) comparison with other OECD countries, (2) the historical change in Japan's technology trade at the industry level, (3) Toshiba's technology trade as a typical case. The conclusion is that Japan is still behind the frontier of innovation.

  12. Prevent Infections During Chemotherapy

    Centers for Disease Control (CDC) Podcasts

    2011-10-24

    This podcast discusses the importance of preventing infections in cancer patients who are undergoing chemotherapy. Dr. Lisa Richardson, CDC oncologist, talks about a new Web site for cancer patients and their caregivers.  Created: 10/24/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC).   Date Released: 10/24/2011.

  13. Chemotherapy for bladder cancer: treatment guidelines for neoadjuvant chemotherapy, bladder preservation, adjuvant chemotherapy, and metastatic cancer

    DEFF Research Database (Denmark)

    Sternberg, Cora N; Donat, S Machele; Bellmunt, Joaquim

    2007-01-01

    with the use of Medline; additional cited works not detected on the initial search regarding neoadjuvant chemotherapy, bladder preservation, adjuvant chemotherapy, and chemotherapy for patients with metastatic urothelial cancer were reviewed. Evidence-based recommendations for diagnosis and management...... the published literature on chemotherapy for patients with locally advanced bladder cancer. This article reports the development of international guidelines for the treatment of patients with locally advanced bladder cancer with neoadjuvant and adjuvant chemotherapy. Bladder preservation is also discussed......, as is chemotherapy for patients with metastatic urothelial cancer. The conference panel consisted of 10 medical oncologists and urologists from 3 continents who are experts in this field and who reviewed the English-language literature through October 2004. Relevant English-language literature was identified...

  14. Role of the Vision Van, a mobile ophthalmic outpatient clinic, in the Great East Japan Earthquake

    Directory of Open Access Journals (Sweden)

    Yuki K

    2014-04-01

    Full Text Available Kenya Yuki,1 Toru Nakazawa,2 Daijiro Kurosaka,3 Tsunehiko Yoshida,4–6 Eduardo C Alfonso,7 Richard K Lee,7 Shigeru Takano,8 Kazuo Tsubota1 1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan; 3Department of Ophthalmology, Iwate Medical University, Iwate, Japan; 4The House of Representatives of Japan, Tokyo, Japan; 5Nagoya University Hospital, Aichi, Japan; 6Aichi Medical University Hospital, Aichi, Japan; 7Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 8Japan Ophthalmological Association, Tokyo, Japan Purpose: The Great East Japan Earthquake of March 11, 2011 triggered powerful tsunami waves off the northeastern Pacific coast of Japan that destroyed almost all of the built-up areas along the coast. The study reported here examined the role played by the Vision Van, a mobile outpatient ophthalmological clinic, in providing eye care to disaster evacuees. Methods: This was a retrospective case-series study of 2,070 victims (male: 732, female: 1,338 who visited the Vision Van. The subjects' medical records were examined retrospectively and analyzed in terms of age, sex, and date of visit to the Vision Van. Information regarding each patient's chief complaint, diagnosis, medication(s prescribed, and eyeglasses and contact lenses provided, was also examined. Results: The Vision Van was used to conduct medical examinations on 39 days between April 23 and June 29, 2011. The average number of subjects visiting the Vision Van each day was 53±31 (range: 7–135, with examinations carried out in Miyagi Prefecture and Iwate Prefecture. The most frequent complaint was a need for eye drops (871/2,070 [42.1%]. The second and third most frequent complaints, respectively, were the need for contact lenses (294/2,070 [14.2%] and eyeglasses (280/2,070 [13.5%]. The most frequent ocular disease diagnosis

  15. Contribution of soil sciences for recovering from damages by the Great East Japan Earthquake

    International Nuclear Information System (INIS)

    Miwa, Eitaro; Miyazaki, Tsuyoshi; Nanzyo, Masami

    2014-01-01

    This symposium was held in September 2013, under the joint hosting of Science Council of Japan, Agricultural Academy of Japan, and Japanese Society of Soil Science and Plant Nutrition, as one of the programs of the Nagoya convention of Japanese Society of Soil Science and Plant Nutrition. The theme was the contribution of soil science to the restoration from the Great East Japan Earthquake and the issues involved in this. As the restoration from the tsunami, the following two topics were presented: 'Situation of Miyagi Prefecture and challenge of soil science', and 'Technological measures for the resumption of farming in tsunami-hit areas in Soma City, Fukushima Prefecture.' As the restoration from the radiation damage caused by Fukushima Daiichi Nuclear Power Station Accident, the following four topics were presented: 'Cooperation between villagers and scholars at Iitate Village; efforts for survey and decontamination with the hands of villagers,' 'Cesium fixation related to on-site soil,' 'Concentration and separation of cesium,' and 'Volume reduction of contaminated soil.' This paper summarizes these six topics of lectures, keynote comments by other specialists and relevant persons, and the atmosphere of the convention on the day. (A.O)

  16. Physical exercise during adjuvant chemotherapy

    NARCIS (Netherlands)

    van Waart, H.

    2017-01-01

    This thesis evaluates the effect of physical exercise during chemotherapy. In chapter two the study design, rationale and methods of the Physical exercise during Adjuvant Chemotherapy Study (PACES) are described. Chapter three presents the effects of the randomized controlled trial evaluating a

  17. Chromonychia Secondary to Chemotherapy

    Directory of Open Access Journals (Sweden)

    Marien Lopes

    2013-06-01

    Full Text Available Chemotherapy drugs can affect the skin and its appendages. Several clinical presentations can be observed, depending on the affected structure. The most common dermatological side effect is chromonychia. The main causative agents are: (1 cyclophosphamide, which can provoke a diffuse, black pigmentation, longitudinal striae and dark grey pigmentation located proximally on the nails; (2 doxorubicin, which promotes dark brown bands alternating with white striae and dark brown pigmentation in transverse bands, and (3 hydroxyurea, which produces a distal, diffuse, dark brown pigmentation. In the majority of cases, the effects are reversible after the suspension of the causative agent for a few months. We report a patient who developed chromonychia while undergoing treatment with cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate and cytarabine for acute lymphocytic leukemia.

  18. Principles of magnetodynamic chemotherapy.

    Science.gov (United States)

    Babincová, M; Leszczynska, D; Sourivong, P; Babinec, P; Leszczynski, J

    2004-01-01

    Basic principles of a novel method of cancer treatment are explained. Method is based on the thermal activation of an inactive prodrug encapsulated in magnetoliposomes via Neél and Brown effects of inductive heating of subdomain superparamagnetic particles to sufficiently high temperatures. This principle may be combined with targeted drug delivery (using constant magnetic field) and controlled release (using high-frequency magnetic field) of an activated drug entrapped in magnetoliposomes. Using this method drug may be applied very selectively in the particular site of organism and this procedure may be repeated several times using e.g. stealth magnetoliposomes which are circulating in a blood-stream for several days. Moreover the magnetoliposomes concentrated by external constant magnetic field in tumor vasculature may lead to embolic lesions and necrosis of a tumor body and further the heat produced for thermal activation of a drug enhances the effect of chemotherapy by local hyperthermic treatment of neoplastic cells.

  19. Epistemic Selectivities and the Valorisation of Nature: The Cases of the Nagoya Protocol and the Intergovernmental Science-Policy Platform for Biodiversity and Ecosystem Services (IPBES

    Directory of Open Access Journals (Sweden)

    Ulrich Brand and Alice B.M. Vadrot

    2013-09-01

    Full Text Available This article addresses the intertwined and contentious relationship between knowledge production and policy-making inside the Convention on Biological Diversity (CBD. We develop the argument that international biodiversity politics is constituted by epistemic selectivities, in which a set of favoured concepts establishes its own institutionalisation by defining ‘what needs to be governed’. Against this background the article aims to analyse the relationship between the Nagoya Protocol on Access and Benefit-Sharing and the process towards the creation of the Intergovernmental Platform for Biodiversity and Ecosystem Services (IPBES, on the one hand, and the increased popularity of the concept of ecosystem services, on the other. We argue that both cases illustrate the ‘pay to conserve logic’, prearranging the terrain of international biodiversity politics and related knowledge production and its influence on political processes. We introduce the concept of epistemic selectivities, in order to understand how this logic materialises in political institutions and to analyse the relationship between hegemonic forms of societal and scientific knowledge and that of policy knowledge. Our argument needs to be understood against the background of the wider context beyond global environmental policy by considering the political economy of biodiversity politics. This article is theoretically informed by the strategic-relational approach and focuses on the relationship between truth and power as well as on the role of the internationalised state of which the CBD is part.

  20. 'Nuclear power education Renaissance' in university. Map of new nuclear researches and education in Japan and its view

    International Nuclear Information System (INIS)

    Ishii, Mamoru; Kudo, Kazuhiko; Kiyanagi, Yoshiaki

    2005-01-01

    Nuclear power education Renaissance is opened toward 21st century new age of the total science of nuclear power. Main universities have a tendency to face new nuclear power researches and education on the view point of cooperation among industry, university, government and region. A trend and characteristics of main universities is reviewed. The nuclear power education and researches in USA is introduced by an example of Purdue University. History and view of nuclear power education in Japan, and new development of nuclear researches and education in ten universities are stated. Ten universities consist of Hokkaido, Tohoku, Tokyo, Nagoya, Kyoto, Kinki, Fukui, Osaka and Kyushu University and Tokyo Institute of Technology. (S.Y.)

  1. Metronomic chemotherapy regimens in oncology

    Directory of Open Access Journals (Sweden)

    M. Yu. Fedyanin

    2016-01-01

    Full Text Available Metronomic chemotherapy implies the regular use of cytotoxic agents in doses much smaller than the maximum tolerable doses for a long time. Preclinical experiments show that this treatment option has a many-sided (antiangiogenic, immunostimulating, and direct cytotoxic effect on tumor. Moreover, this approach has gained the widest acceptance in treating patients with metastatic breast cancer in clinical practice. By taking into account the high activity of angiogenesis in colon cancer progression, it is interesting to study the impact of metronomic chemotherapy regimens for this nosological entity as well. This literature review considers not only the history of metronomic chemotherapy, the mechanisms of action, and a range of drugs having an antitumor effect in the metronomic regimens, but also analyzes clinical trials of metronomic chemotherapy regimens in patients with metastatic colon cancer.

  2. chemotherapy at the uch, ibadan.

    African Journals Online (AJOL)

    , at different times during the course of their treatment with chemotherapy received palliative radiotherapy to sites of painfial bony lesions and/or fracture sites (after immobilization). External radiation therapy was delivered through a cobalt-60 ...

  3. Acute emesis: moderately emetogenic chemotherapy

    DEFF Research Database (Denmark)

    Herrstedt, Jørn; Rapoport, Bernardo; Warr, David

    2011-01-01

    receiving multiple cycles of moderately emetogenic chemotherapy will be reviewed. Consensus statements are given, including optimal dose and schedule of serotonin(3) receptor antagonists, dexamethasone, and neurokinin(1) receptor antagonists. The most significant recommendations (and changes since the 2004...... version of the guidelines) are as follows: the best prophylaxis in patients receiving moderately emetogenic chemotherapy (not including a combination of an anthracycline plus cyclophosphamide) is the combination of palonosetron and dexamethasone on the day of chemotherapy, followed by dexamethasone...... on days 2-3. In patients receiving a combination of an anthracycline plus cyclophosphamide, a combination of a serotonin(3) receptor antagonist plus dexamethasone, plus the neurokinin(1) receptor antagonist aprepitant on the day of chemotherapy, followed by aprepitant days 2-3, is recommended....

  4. Safety and benefits of self-expandable metallic stents with chemotherapy for malignant gastric outlet obstruction.

    Science.gov (United States)

    Miyabe, Katsuyuki; Hayashi, Kazuki; Nakazawa, Takahiro; Sano, Hitoshi; Yamada, Tomonori; Takada, Hiroki; Naitoh, Itaru; Shimizu, Shuya; Kondo, Hiromu; Nishi, Yuji; Yoshida, Michihiro; Umemura, Shuichiro; Hori, Yasuki; Kato, Akihisa; Ohara, Hirotaka; Joh, Takashi

    2015-07-01

    The influence of chemotherapy on placement of self-expandable metallic stents (SEMS) for malignant gastric outlet obstruction (MGOO) has not been evaluated extensively. We investigated the influence of chemotherapy on the clinical outcomes of SEMS placement for MGOO. A total of 152 cancer patients with MGOO from a university hospital and affiliate hospitals were included. The patients were classified according to chemotherapy status and evaluated for palliative efficacy and safety of SEMS placement. Technical success rate, time to oral intake, and parameters indicating improvement of physical condition did not differ between the with- and without-chemotherapy groups after stent placement. Re-intervention and stent migration were significantly more frequent in the with-chemotherapy group than in the without-chemotherapy group after stent placement (re-intervention, 32.4% vs 7.8%, P = 0.0005; stent migration, 13.5% vs 1.7%, P = 0.0097). The frequency of adverse events did not differ between the with- and without-chemotherapy groups. Although chemotherapy after stent placement was an independent predictive factor for shortening the stent patency period (hazard ratio [HR], 3.10; P = 0.0264), the use of additional stents facilitated uneventful recovery and further prolonged survival time (HR, 0.60; P = 0.0132). Various cancer patients with MGOO can undergo SEMS placement safely regardless of chemotherapy, and concurrent chemotherapy after stent placement can prolong survival time, although re-intervention and stent migration may be increased. © 2015 The Authors. Digestive Endoscopy © 2015 Japan Gastroenterological Endoscopy Society.

  5. GPS/acoustic seafloor geodetic observation in the subduction zone around Japan (Invited)

    Science.gov (United States)

    Sato, M.; Kido, M.; Tadokoro, K.; Fujimoto, H.

    2013-12-01

    GPS/acoustic (GPS/A) seafloor geodetic observation is a precise seafloor positioning technique and has made great progress over the last decade. GPS/A observation determines the positions of acoustic mirror-type transponders installed on the seafloor by combining the two techniques of kinematic GPS and acoustic ranging through a ship or a buoy. The original idea was proposed by Prof. Spiess at the Scripps Institution of Oceanography in 1985 and its protocol and hardware were made through research and development of his group by the mid-1990s. In Japan, three research groups, Japan Coast Guard, Tohoku University and Nagoya University, began to develop the GPS/A observation system in the 1990s, established GPS/A observation sites mainly on the landward slope of the plate boundaries around Japan, such as the Japan Trench and the Nankai trough, and have been carrying out campaign observations since around 2000. The primary purpose of our observation is to detect and monitor the crustal deformation caused by the subduction of the oceanic plate near the plate boundary where large interplate earthquakes have repeatedly occurred. By continuous efforts for over a decade, the positioning precision has achieved a few centimeters and seafloor movements such as intraplate deformation and coseismic displacements have been successfully detected. In particular, regarding the 2011 Tohoku-oki earthquake (M9.0), which occurred off northeastern Japan on March 11, 2011, east-southeastward coseismic displacements of up to 31 m were observed above the focal region, especially close to the epicenter, while those detected by on-land GPS measurements over 100 km away from the epicenter, conducted by the Geospatial Information Authority of Japan, was up to 5.3 m. Coseismic slip models on the plate boundary estimated from not only GPS data but also GPS/A results indicate that a huge slip of more than 50 m generated close to the trench axis, which was much larger than that estimated from GPS

  6. Technology Education in Japan.

    Science.gov (United States)

    Murata, Shoji; Stern, Sam

    1993-01-01

    Describes the history, current status, and future direction of technology education in Japan, including the process of curriculum transition, secondary and postsecondary structure, and lack of resources. (SK)

  7. IRBA SERIES : Accounting In Japan

    OpenAIRE

    Arai, Kiyomitsu

    1994-01-01

    Preface / Legal and Conceptual Framework of Accounting in Japan / Setting Accounting Standards in Japan - The American Influence and The Present Status / Accounting Education and Profession in Japan / The International Harmonization of Accounting Standards / The Accounting Standard Setting in Japan and Its Responses to International Accounting Standards / Selected Bibliography for Accounting in Japan

  8. Zebrin II Expressing Purkinje Cell Phenotype—Related and—Unrelated Cerebellar Abnormalities in Ca˅2.1 Mutant, Rolling Mouse Nagoya

    Directory of Open Access Journals (Sweden)

    Kazuhiko Sawada

    2010-01-01

    Full Text Available Rolling mouse Nagoya is an ataxic mutant mouse that carries a mutation in a gene encoding for the alpha 1A subunit of the voltage-gated P/Q-type Ca2+ channel (Ca˅2.1. This report summarizes our studies and others concerning cerebellar abnormalities in rolling mice based on chemical neuroanatomy. While there are no obvious cerebellar deformations in this mutant mouse, the altered functions of Purkinje cells can be revealed as a reduced expression of type 1 ryanodine receptor (RyR1 in all Purkinje cells uniformly throughout the cerebellum, and as an ectopic expression of tyrosine hydroxylase (TH in the Purkinje cell subsets with the zebrin II—immunopositive phenotype. As the mutated Ca˅2.1 channel is expressed at uniform levels in all Purkinje cells, its copresence with RyR1 staining suggests that a Ca˅2.1 channel dysfunction links with the expression of RyR1 in Purkinje cells of rolling mice. However, an ectopic expression of TH in the Purkinje cells is topologically related to the projection of corticotrophin-releasing factor—immunopositive climbing fibers rather than expression of the mutated Ca˅2.1 channel. On the other hand, increased levels of serotonin (5-HT in 5-HTergic fibers were revealed immunohistochemically in Purkinje cells of the vermis of rolling cerebellum. Thus, to determine whether or not cerebellar abnormalities are related to Purkinje cell populations revealed by zebrin II expression is essential for enhancing our understanding of the pathogenesis of hereditary cerebellar ataxic mutants such as rolling mice.

  9. Medical genetics in Japan.

    Science.gov (United States)

    Matsuo, M

    1995-01-01

    In Japan genetic diseases are getting more popular in medicine, because of increased awareness of the role of genetic determinants of diseases. Care for patients with inherited disease is one of the current big problems. In this review, programs developed to support Duchenne muscular dystrophy patients are described as an example of medical services available for genetic diseases in Japan.

  10. Reform: Learning from Japan.

    Science.gov (United States)

    Barnes, Michael

    1999-01-01

    Examining differences between education in the United States and in Japan means analyzing cultural dissimilarities. An overview of Japan's educational makeup, curriculum, and graduation rates provides background in comparing educational systems for future reforms. This paper examines Japanese school structures, government support, institutional…

  11. Renewable energies in Japan

    International Nuclear Information System (INIS)

    Rosello-Garcia, M.

    2003-04-01

    Dependent upon its energy supplies, the Japan aims to develop its renewable energies production. This evolution will also agrees the engagements of the Kyoto protocol to reduce the carbon dioxide emissions. To reach in 2010 7% of the energy consumption by a ''clean energy'', the Japan supports and finances many research projects on the renewable energies. (A.L.B.)

  12. Everywhere in Japan: an international approach to working with commercial gay businesses in HIV prevention.

    Science.gov (United States)

    Sherriff, Nigel; Koerner, Jane; Kaneko, Noriyo; Shiono, Satoshi; Takaku, Michiko; Boseley, Ross; Ichikawa, Seiichi

    2017-06-01

    In the UK and Japan, there is concern regarding rising rates of annual new HIV infections among Men who have Sex with Men (MSM). Whilst in the UK and Europe, gay businesses are increasingly recognized as being important settings through which to deliver HIV prevention and health promotion interventions to target vulnerable populations; in Japan such settings-based approaches are relatively underdeveloped. This article draws on qualitative data from a recently completed study conducted to explore whether it is feasible, acceptable and desirable to build on the recent European Everywhere project for adaptation and implementation in Japan. A series of expert workshops were conducted in Tokyo, Nagoya and Osaka with intersectoral representatives from Japanese and UK non-governmental organizations (NGOs), gay businesses, universities and gay communities (n = 46). Further discussion groups and meetings were held with NGO members and researchers from the Japanese Ministry of Health, Labour and Welfare's Research Group on HIV Prevention Policy, Programme Implementation and Evaluation among MSM (n = 34). The results showed that it is desirable, feasible and acceptable to adapt and implement a Japanese version of Everywhere. Such a practical, policy-relevant, settings-based HIV prevention framework for gay businesses may help to facilitate the necessary scale up of prevention responses among MSM in Japan. Given the high degree of sexual mobility between countries in Asia, there is considerable potential for the Everywhere Project (or its Japanese variant) to be expanded and adapted to other countries within the Asia-Pacific region. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  13. Trajectory of chemotherapy for patients with EGFR wild-type advanced pulmonary adenocarcinoma: a single-institution retrospective study

    Directory of Open Access Journals (Sweden)

    Minami S

    2017-02-01

    Full Text Available Seigo Minami, Yoshitaka Ogata, Shouichi Ihara, Suguru Yamamoto, Kiyoshi Komuta Department of Respiratory Medicine, Osaka Police Hospital, Osaka, Japan Background: Pulmonary adenocarcinoma, recently benefited by new cytotoxic and molecularly targeted drugs, has been classified by driver mutations, such as EGFR mutations. The aim of this study was to research the proportions of patients treated with first- to third-line chemotherapy and to find influential factors for the introduction of chemotherapy and survival benefit from chemotherapy.Materials and methods: Data were collected retrospectively on patients who met the following criteria: adenocarcinoma, diagnosed between June 2007 and March 2015 at our hospital, stage IIIB or IV, and EGFR wild type. A nonchemotherapy group of patients who did not receive chemotherapy was compared with a chemotherapy group of patients who received it. The patients who had received first- to third-line chemotherapy between June 2007 and November 2015 at our hospital were also analyzed.Results: During the study period, 46 patients did not receive chemotherapy, while 148, 89, and 48 received first-, second- and third-line chemotherapy, respectively. As predictive factors for unlikely chemotherapy, multivariate logistic analysis detected Eastern Cooperative Oncology Group (ECOG performance status (PS ≥2, hemoglobin <13.2 g/dL, creatinine clearance (Ccr <50.4 mL/min, and CRP ≥0.53 mg/dL. As factors predicting shorter survival after chemotherapy, multivariate Cox proportional-hazard analyses detected age ≥75 years, ECOG PS ≥2, lower lymphocyte counts, and higher CRP for the first line; female, higher neutrophil counts, lower lymphocyte counts, reduced Ccr, hyponatremia, and shorter interval between first- and second-line chemotherapy for the second line; and age ≥75 years, body mass index <18.5 kg/m2, higher neutrophil counts, lower lymphocyte counts, hyponatremia, higher lactate dehydrogenase, and higher

  14. Nuclear energetics of Japan

    International Nuclear Information System (INIS)

    Sivintsev, Yu.V.

    2001-01-01

    Data on the current state and development of the nuclear energetics of Japan are reviewed. Preference of the strategy of tolerant development of the nuclear energetics of Japan including creation of the power nuclear energetics with the closed nuclear fuel cycle is noted. Realization and development of the program for the creating fast breeder reactor will provide to achieve total independence from import of any types of energy carriers including the fuel for nuclear fuel cycle. Scientific elaborations in Japan are conjectured the correlation of different types of fuel (oxide, metal, nitride), energy carriers (sodium, heavy metals, gas and water) and reactor power (large NPP, middle and small power plants) [ru

  15. Microelectronics in Japan

    Science.gov (United States)

    Boulton, William R.

    1995-02-01

    The purpose of this JTEC study is to evaluate Japan's electronic manufacturing and packaging capabilities within the context of global economic competition. To carry out this study, the JTEC panel evaluated the framework of the Japanese consumer electronics industry and various technological and organizational factors that are likely to determine who will win and lose in the marketplace. This study begins with a brief overview of the electronics industry, especially as it operates in Japan today. Succeeding chapters examine the electronics infrastructure in Japan and take an in-depth look at the central issues of product development in order to identify those parameters that will determine future directions for electronic packaging technologies.

  16. Managing Chemotherapy Side Effects: Constipation

    Science.gov (United States)

    ... Raw or cooked vegetables, such as broccoli, corn, green beans, peas, and spinach Snacks ••Granola ••Nuts ••Popcorn •• ... gov/livehelp NCI has a series of 18 Chemotherapy Side Effects Sheets at: www.cancer.gov/chemo- ...

  17. Chemotherapy of Human African Trypanosomiasis

    Directory of Open Access Journals (Sweden)

    Cyrus J. Bacchi

    2009-01-01

    Full Text Available Human Africa trypanosomiasis is a centuries-old disease which has disrupted sub-Saharan Africa in both physical suffering and economic loss. This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent development of promising non-toxic combination chemotherapy suitable for use in rural clinics.

  18. Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis.

    LENUS (Irish Health Repository)

    Kelly, Emer

    2012-02-01

    Lymphangioleiomyomatosis is a rare cause of pneumothorax in women. We present the case of a 48-year-old woman with lymphangioleiomyomatosis, who had never had a pneumothorax prior to commencing chemotherapy for breast cancer. During chemotherapy she developed 3 pneumothoraces and 2 episodes of pneumomediastinum. We suggest that the pneumothoraces were caused by the chemotherapy. To our knowledge, this is the first reported case of chemotherapy triggering pneumothoraces in a woman with lymphangioleiomyomatosis.

  19. [History of neurology and education on neurology in Japan].

    Science.gov (United States)

    Kuzuhara, Shigeki

    2009-11-01

    The first medical society of Japanese neurologists and psychiatrists was founded in 1902, but psychiatrists gradually dominated in number. New "Japanese Society of Neurology" (JSN) was founded in 1960. The number of members was only 643 in 1960, while it rose up to 8,555 in 2009, including regular, junior, senior and associate members. JSN contributed much to solve the causes and treatment of the medicosocial and iatrogenic diseases such as Minamata disease and SMON (subacute myelopticoneuropathy) at its early period. In undergraduate education at medical school neurology is one of the core subjects in the curriculum, and almost all the 80 medical schools have at least one faculty neurologist. The Board of neurology of JSN was started in 1975, as the third earliest of the Japanese Medical Associations. It takes at least 6 years' clinical training after graduating from the medical school to take the neurology Board examinations. By 2009, 4,000 members passed the Board examinations. In 2002 JSN published evidence-based "Treatment Guidelines 2002" of 6 diseases: Parkinson's disease, stroke, chronic headache, dementia and ALS. As to the international issues, JSN hosted the 12th World Congress of Neurology in 1981, and international activities markedly increased after that. The first informal meeting with JSN and Korean Neurological Association (KNA) was held at the 48th JSN Annual Meeting in Nagoya in May 2007. In May 2008 the KNA-JSN 1st Joint symposium was held at the 49th Annual Meeting of JSN in Yokohama on "International comparison of neurological disorders: focusing on spinocerebellar atrophies (SCA) and epilepsies". In May 2009, KNA-JNS 2 nd Joint Symposium was held at the 50th JSN Annual Meeting in Sendai, inviting a speaker from Taiwan Neurological Society, on the subject "History and Education of Neurology in Japan, Korea and Taiwan". In this symposium, a strategy to make up the Northeast Asian Neurological Association was discussed.

  20. Space communications in Japan

    Science.gov (United States)

    Mori, T.

    This paper outlines some of the planned satellite comunication projects in Japan over the next 5-7 years. In addition, Japanese space development policies are set out along with a historic review of the development of artificial satellites.

  1. Kirishima, Japan Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The shield volcano consists of more than 20 eruptive centers over a 20 x 30 km area that also includes Japan's first national park. Sixty-nine eruptions have been...

  2. A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma.

    Science.gov (United States)

    Wyse, Emily; Handa, James T; Friedman, Alan D; Pearl, Monica S

    2016-08-01

    Retinoblastoma is a malignancy of the retina that usually presents before the age of 5 years. Sporadic retinoblastoma is most often unilateral and with no hereditary influence, whereas familial retinoblastoma presents unilaterally or bilaterally in conjunction with genetic inheritance. Several treatments have been attempted with the goals of saving the child's life, salvaging the eye, and preserving vision. Alternative methods including external beam radiation, systemic chemotherapy and focal therapies have been shown to be effective but carry a risk of enucleation and other complications proportional to the severity of the tumor. Selective intra-arterial chemotherapy for retinoblastoma began in 1988 in Japan and has emerged in the last 7 years in the United States as a feasible, effective and minimally invasive treatment option. We review the retinoblastoma treatment literature focusing on intra-arterial chemotherapy.

  3. Mobile Marketing in Japan

    OpenAIRE

    Noah H. N. Lynn; Paul D. Berger

    2014-01-01

    In this paper we describe the state of mobile marketing in Japan. We consider the various aspects of mobile marketing in Japan and what has led to the overwhelming adoption by Japanese youth, and to a degree Japanese society as a whole, of social media and associated activities. This growth of mobile marketing has dramatic, positive implications for marketing, in general, as well as for the sale of selected product classes. We also consider markers for suggesting what the future of mobile mar...

  4. VSATs in Japan

    Science.gov (United States)

    Fujii, Akira

    1993-08-01

    In Japan, VSAT private domestic communications satellites, JCSAT and SuperBird, carrying Ku-band transponders, were launched in 1989. To expedite a wider use of these VSAT systems, regulations were amended in June 1989 to permit simplified licensing procedures for the VSATs which conformed to technical standards. This contribution describes the usage of VSAT systems in Japan along with the licensing procedures and the technical standards.

  5. Prescription of Prophylactic Antiemetic Drugs for Patients Receiving Chemotherapy With Minimal and Low Emetic Risk.

    Science.gov (United States)

    Okuyama, Ayako; Nakamura, Fumiaki; Higashi, Takahiro

    2017-03-01

    The use of antiemetic drugs for patients receiving chemotherapy with low or minimal emetic risk has been recognized as a growing concern for health care costs and patients' welfare. Relatively few studies have examined antiemetic prophylaxis or treatment of emesis associated with chemotherapy with lower emetic risk. To describe the pattern in Japan of overprescribing prophylactic antiemetic drugs to patients who have received intravenous chemotherapy with minimal or low emetic risk. This secondary analysis of a health insurance claims database linked with the hospital-based cancer registry of 122 designated cancer care hospitals covered the period from September 1, 2010, to December 31, 2012. Data were included from patients who (1) were diagnosed with breast, lung, colorectal, stomach, cervical, or prostate cancer; (2) were 20 years or older at the time of the diagnosis; and (3) received intravenous chemotherapy with minimal or low emetic risk. The data from patients with advanced stage cancer (stage IV) were excluded. Data were analyzed from March 20, 2014, to June 30, 2016. The percentage of chemotherapy administration involving patients prescribed prophylactic antiemetic drugs, namely, a neurokinin 1 receptor antagonist, serotonin receptor antagonist, and/or dexamethasone, was calculated. The costs of potentially unnecessary antiemetic drugs were estimated using the National Health Insurance drug price list for 2011. A total of 8545 patients (5886 women [68.9%] and 2659 men [31.1%]; mean [SD] age, 61.9 [12.8] years) undergoing 73 577 administrations of chemotherapy with minimal emetic risk (2464 patients; 22 619 administrations) or low emetic risk (6081 patients; 50 958 administrations) were identified. Of these, patients who received 24 373 administrations of chemotherapy with a low emetic risk (47.8%) and 633 administrations of chemotherapy with a minimal emetic risk (2.8%) were prescribed serotonin receptor antagonists and dexamethasone. Outpatients

  6. [Improving nursing staff accuracy in administering chemotherapy].

    Science.gov (United States)

    Lin, Chin-Ying; Chu, Yun-Li; Chiou, Yen-Gan; Chiang, Ming-Chu

    2009-12-01

    As most anticancer drugs are cytotoxic, their safe and error-free application is important. We analyzed data from the hematology-oncology ward chemotherapy checklist dated January 13th through February 3rd, 2007 and found accuracy rates for chemotherapy drug usage as low as 68.4%. Possible causes identified for this poor result include incomplete chemotherapy standards protocols, lack of chemotherapy quality control, and insufficient chemotherapy knowledge amongst nursing staff. This project aimed to improve the accuracy of nursing staff in administering chemotherapy and to raise nursing staff knowledge regarding chemotherapy. Our strategies for improvement included completing a chemotherapy standards protocol, establishing a chemotherapy quality-control monitoring system, augmenting chemotherapy training and adding appropriate equipment and staff reminders. After strategies were implemented, accuracy in chemotherapy administration rose to 96.7%. Related knowledge amongst nursing staff also improved from an initial 77.5% to 89.2%. Implementing the recommended measures achieved a significant improvement in the accuracy and quality of chemotherapy administered by nursing personnel.

  7. Japan's nuclear power tightrope

    International Nuclear Information System (INIS)

    Cross, M.

    1991-01-01

    This paper reports that early in February, just as Japan's nuclear energy program was regaining a degree of popular support after three years of growing opposition, an aging pressurized-water reactor at Mihama in western Japan sprang a leak in its primary cooling system. The event occasioned Japan's first nontest use of an emergency core-cooling system. It also elicited a forecast of renewed public skepticism about nuclear power form the Ministry of International Trade and Industry (MITI), the Government body responsible for promoting and regulating Japan's ambitious nuclear power program. Public backing for this form of energy has always been a delicate flower in Japan, where virtually every school child visits the atomic bomb museums at Hiroshima and Nagasaki. Yet the country, which imports 80 percent of its energy and just about all its oil, is behind only the United States, France, and the Soviet Union in installed nuclear capacity. In fiscal 1989, which started in April, Japan's 39 nuclear power stations accounted for 25.5 percent of electricity generated - the largest contribution - followed b coal and natural gas. Twelve more plants are under construction

  8. Industrial lasers in Japan

    Science.gov (United States)

    Karube, Norio

    1991-03-01

    I am to report on some aspects of industrial lasers in Japan. Mostly centering on the market. In Japan, the history of laser developnent is rather profound. And long. Ever since the first invention of the laser in this country in 1960. This is partly because of the fact that in Japan the spectroscopic studies of the ruby was very popular in the late 1950's. Ever since niost of the work has been done in the research laboratories of the industry, not in the universities or not in the governmental laboratories. And since that time our first activity was mainly centering on the basic research, but after that time we have the evolution of the technology. One of the features in Japan is that the activity of developement and research of laser technology from the very basic phase up to the present commercialization has been done by the same group of people, including ine. We had a national project which ended about six years ago which was sponsored by MITI. MITI is Ministry of International Trade and Industry in Japan. And because of this national project, the effect of this project had a very enlightening effect in Japan. And after that our Japanese laser market became very flourishing.

  9. Cancer cell adaptation to chemotherapy

    International Nuclear Information System (INIS)

    Di Nicolantonio, Federica; Johnson, Penny; Somers, Shaw S; Toh, Simon; Higgins, Bernie; Lamont, Alan; Gulliford, Tim; Hurren, Jeremy; Yiangou, Constantinos; Cree, Ian A; Mercer, Stuart J; Knight, Louise A; Gabriel, Francis G; Whitehouse, Pauline A; Sharma, Sanjay; Fernando, Augusta; Glaysher, Sharon; Di Palma, Silvana

    2005-01-01

    Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells are difficult. Studies of human tumors show that cells adapt to chemotherapy, but it has been largely assumed that clonal selection leads to the resistance of recurrent tumors. Cells derived from 47 tumors of breast, ovarian, esophageal, and colorectal origin and 16 paired esophageal biopsies were exposed to anticancer agents (cisplatin; 5-fluorouracil; epirubicin; doxorubicin; paclitaxel; irinotecan and topotecan) in short-term cell culture (6 days). Real-time quantitative PCR was used to measure up- or down-regulation of 16 different resistance/target genes, and when tissue was available, immunohistochemistry was used to assess the protein levels. In 8/16 paired esophageal biopsies, there was an increase in the expression of multi-drug resistance gene 1 (MDR1) following epirubicin + cisplatin + 5-fluorouracil (ECF) chemotherapy and this was accompanied by increased expression of the MDR-1 encoded protein, P-gp. Following exposure to doxorubicin in vitro, 13/14 breast carcinomas and 9/12 ovarian carcinomas showed >2-fold down-regulation of topoisomerase IIα (TOPOIIα). Exposure to topotecan in vitro, resulted in >4-fold down-regulation of TOPOIIα in 6/7 colorectal tumors and 8/10 ovarian tumors. This study suggests that up-regulation of resistance genes or down-regulation in target genes may occur rapidly in human solid tumors, within days of the start of treatment, and that similar changes are present in pre- and post-chemotherapy biopsy material. The molecular processes used by each tumor appear to be linked to the drug used, but there is also heterogeneity between individual tumors, even those with the same histological type, in the pattern and magnitude of response to the same drugs. Adaptation

  10. Cancer cell adaptation to chemotherapy

    Directory of Open Access Journals (Sweden)

    Higgins Bernie

    2005-07-01

    Full Text Available Abstract Background Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells are difficult. Studies of human tumors show that cells adapt to chemotherapy, but it has been largely assumed that clonal selection leads to the resistance of recurrent tumors. Methods Cells derived from 47 tumors of breast, ovarian, esophageal, and colorectal origin and 16 paired esophageal biopsies were exposed to anticancer agents (cisplatin; 5-fluorouracil; epirubicin; doxorubicin; paclitaxel; irinotecan and topotecan in short-term cell culture (6 days. Real-time quantitative PCR was used to measure up- or down-regulation of 16 different resistance/target genes, and when tissue was available, immunohistochemistry was used to assess the protein levels. Results In 8/16 paired esophageal biopsies, there was an increase in the expression of multi-drug resistance gene 1 (MDR1 following epirubicin + cisplatin + 5-fluorouracil (ECF chemotherapy and this was accompanied by increased expression of the MDR-1 encoded protein, P-gp. Following exposure to doxorubicin in vitro, 13/14 breast carcinomas and 9/12 ovarian carcinomas showed >2-fold down-regulation of topoisomerase IIα (TOPOIIα. Exposure to topotecan in vitro, resulted in >4-fold down-regulation of TOPOIIα in 6/7 colorectal tumors and 8/10 ovarian tumors. Conclusion This study suggests that up-regulation of resistance genes or down-regulation in target genes may occur rapidly in human solid tumors, within days of the start of treatment, and that similar changes are present in pre- and post-chemotherapy biopsy material. The molecular processes used by each tumor appear to be linked to the drug used, but there is also heterogeneity between individual tumors, even those with the same histological type, in the

  11. Penile carcinoma: The role of chemotherapy

    Directory of Open Access Journals (Sweden)

    Raju Titus Chacko

    2006-01-01

    Full Text Available The role of cytotoxic chemotherapy in the management of carcinoma of the penis is not clearly defined. Patients may receive chemotherapy in the neoadjuvant setting to help optimize surgery, the adjuvant setting to improve outcomes with surgery and in the setting of advanced disease for palliation. Chemotherapy may also be combined with radiation to increase response rates and improve survival. We have briefly reviewed the possible roles of chemotherapy in the management of carcinoma of the penis and present a retrospective analysis of a cohort of patients who received chemotherapy at our centre for carcinoma of the penis.

  12. Combined chemotherapy and intra-arterial chemotherapy of retinoblastoma

    Directory of Open Access Journals (Sweden)

    Saerom Choi

    2013-06-01

    Full Text Available &lt;b&gt;Purpose:&lt;/b&gt; Retinoblastoma (RB is the most common primary malignant intraocular tumor in children. Although systemic chemotherapy has been the primary treatment, intra-arterial chemotherapy (IAC represents a new treatment option. Here, we performed alternate systemic chemotherapy and IAC and retrospectively reviewed the efficacy and safety of this approach. &lt;b&gt;Methods:&lt;/b&gt; Patients diagnosed with intraocular RB between January 2000 and December 2011 at Severance Children’s Hospital, Yonsei University, were reviewed. Before February 2010, the primary treatment for RB was chemotherapy (non-IAC/CTX. Since February 2010, the primary treatment for RB has been IAC (IAC/CTX. External beam radiotherapy or high-dose chemotherapy (HDCTX were used as “last resort” treatments just prior to enucleation at the time of progression or recurrence during primary treatment. Enucleation-free survival (EFS and progression-free survival were assessed. &lt;b&gt; Results:&lt;/b&gt; We examined 19 patients (median age, 11.9 months; range, 1.4 to 75.6 months with a sum of 25 eyes, of which, 60.0% were at advanced Reese Ellsworth (RE stages. The enucleation rate was 33.3% at early RE stages and 81.8% at advanced RE stages (P =0.028. At 36 months, EFS was significantly higher in the IAC/CTX group than in the non-IAC/CTX group (100.0% vs. 40.0%, P=0.016. All 5 patients treated with IAC achieved eye preservation, although most patients were at advanced RE stages (IV-V. &lt;b&gt;Conclusion:&lt;/b&gt; Despite the limitation of a small sample size, our work shows that an alternative combined approach using IAC and CTX may be safe and effective for eye preservation in advanced RB.

  13. Experimental studies on cancer chemotherapy

    International Nuclear Information System (INIS)

    1976-08-01

    The further development of the chemotherapy of cancer in the experimental and clinical fields necessitates a profound knowledge of its chemical, biochemical and pharmacological fundamentals and the mechanism of physiological and pathological growth processes. The 'Arbeitsgemeinschaft Zytostatika' includes chemists, biochemists, pharmacologists, molecular biologists, physicians and immunologists of various scientific institutes and clinics in the Federal Republic of Germany and in West Berlin. It is their aim to carry out basic research as well as clinical-orientated research in the field of the chemotherapy of cancer. In the 15 years of cooperation, fundamental knowledge was gained, especially in the field of the cytotoxic specificity and cancerotoxic selectivity of alkylating cytostatics. New cytostatics with a greater oncostatic selectivity and an altered spectrum of activity were tested and greater knowledge was won on the molecular-biological prerequisites of a rational drug design. (orig.) [de

  14. Metastatic hidradenocarcinoma: Surgery and chemotherapy.

    Science.gov (United States)

    Amel, Trabelsi; Olfa, Gharbi; Faten, Hammedi; Makrem, Hochlef; Slim, Ben Ahmed; Moncef, Mokni

    2009-12-01

    Hidradenocarcinoma is a rare carcinoma of high malignant potential. It most metastasizes to regional lymph nodes and distant viscera. We report a case of 52-year-old woman who presented with an invasive hidradenocarcinoma of the finger, treated with surgical excision. The patient presented with skin and lymph node metastases four years after, treated by chemotherapy. Hidradenocarcinoma is an aggressive tumor. It seems important to use adjuvant therapies particularly for recurrent and metastatic forms.

  15. Metastatic hidradenocarcinoma: Surgery and chemotherapy

    OpenAIRE

    Mokni Moncef; Hochlef Makrem; Ben Ahmed Slim; Hammedi Faten; Gharbi Olfa; Trabelsi Amel

    2009-01-01

    Context: Hidradenocarcinoma is a rare carcinoma of high malignant potential. It most metastasizes to regional lymph nodes and distant viscera. Case report: We report a case of 52-year-old woman who presented with an invasive hidradenocarcinoma of the finger, treated with surgical excision. The patient presented with skin and lymph node metastases four years after, treated by chemotherapy. Conclusion: Hidradenocarcinoma is an aggressive tumor. It seems important to use adjuvant therapies parti...

  16. Japan steel mill perspective

    Energy Technology Data Exchange (ETDEWEB)

    Murase, K. [Kobe Steel Ltd., Tokyo (Japan)

    2004-07-01

    The international and Japan's steel industry, the coking coal market, and Japan's expectations from Canada's coal industry are discussed. Japan's steel mills are operating at full capacity. Crude steel production for the first half of 2004 was 55.8 million tons. The steel mills are profitable, but costs are high, and there are difficulties with procuring raw materials. Japan is trying to enhance the quality of coke, in order to achieve higher productivity in the production of pig iron. Economic growth is rising disproportionately in the BRICs (Brazil, Russia, India, and China), with a large increase in coking coal demand from China. On the supply side, there are several projects underway in Australia and Canada to increase production. These include new developments by Elk Valley Coal Corporation, Grande Cache Coal, Western Canadian Coal, and Northern Energy and Mining in Canada. The Elga Mine in the far eastern part of Russia is under development. But the market is expected to remain tight for some time. Japan envisions Canadian coal producers will provide a stable coal supply, expansion of production and infrastructure capabilities, and stabilization of price. 16 slides/overheads are included.

  17. Cultural Astronomy in Japan

    Science.gov (United States)

    Renshaw, Steven L.

    While Japan is known more for its contributions to modern astronomy than its archaeoastronomical sites, there is still much about the culture's heritage that is of interest in the study of cultural astronomy. This case study provides an overview of historical considerations necessary to understand the place of astronomy in Japanese society as well as methodological considerations that highlight traditional approaches that have at times been a barrier to interdisciplinary research. Some specific areas of study in the cultural astronomy of Japan are discussed including examples of contemporary research based on interdisciplinary approaches. Japan provides a fascinating background for scholars who are willing to go beyond their curiosity for sites of alignment and approach the culture with a desire to place astronomical iconography in social context.

  18. Concomitant postoperative radiation and chemotherapy following surgery was associated with improved overall survival in patients with FIGO stages III and IV endometrial cancer

    International Nuclear Information System (INIS)

    Nakayama, Kentaro; Ishikawa, Masako; Miyazaki, Khoji; Nagai, Yutaka; Aoki, Yoichi

    2010-01-01

    The aim of this study was to investigate the usefulness of concomitant postoperative radiation and chemotherapy in patients with the International Federation of Gynecology and Obstetrics (FIGO) stages III and IV endometrial cancer. A retrospective review at Shimane University and Ryukyu University, Japan, was performed of 76 patients with FIGO stages III and IV endometrial cancer. All patients had received a comprehensive staging procedure including hysterectomy, bilateral salpingo-oophorectomy, ±selective pelvic/aortic lymphadenectomy, surgical debulking, and treatment with adjuvant chemotherapy and/or radiotherapy. Seventy-six patients with FIGO stages III and IV endometrial cancer were identified who received postoperative adjuvant therapies; 26% (N=20) received radiotherapy alone, 40% (N=30) chemotherapy alone, and 34% (N=26) chemotherapy and radiotherapy. The median age was 55 years; 92% had the endometrioid type and 97% were optimally debulked. The median follow-up period was 54 (range 6-188) months. Combination therapy with chemotherapy and radiation correlated with longer overall survival compared with either chemotherapy alone (P=0.0298) or chemotherapy alone+radiation alone (P=0.0345). Combination therapy correlated with longer overall survival compared with radiation alone with marginal significance (P=0.0521). No significant differences in the disease-free interval were seen among the combination therapy and chemotherapy alone or radiation alone groups. Combined treatment with radiation and chemotherapy may improve overall survival in patients with FIGO stages III and IV endometrial cancer. (author)

  19. Oncology nurses' recognition of supportive care needs and symptoms of their patients undergoing chemotherapy.

    Science.gov (United States)

    Nakaguchi, Tomohiro; Okuyama, Toru; Uchida, Megumi; Ito, Yoshinori; Komatsu, Hirokazu; Wada, Makoto; Akechi, Tatsuo

    2013-04-01

    To assess the accuracy of oncology nurses' recognition of supportive care needs and symptoms of their patients undergoing chemotherapy. The participants comprised randomly selected cancer outpatients receiving chemotherapy in an ambulatory setting and 17 oncology nurses working in two chemotherapy units in Japan. For assessment of the patients' supportive care needs and symptoms, the patients were asked to respond to a validated self-administered questionnaire. The oncology nurses completed a survey in which they indicated their perception of the level of the same set of needs or symptoms. The two data sets obtained from the patients and nurses were compared statistically to assess the accuracy of the oncology nurses' recognition of their patients' needs and symptoms. Complete data sets were available for 439 patients. The most common primary cancers were breast cancer (36.0%), followed by colorectal (24.4%) and lung (12.3%) cancers. Nurses' awareness of their patients' supportive care needs and physical and psychological symptoms were less than optimal in routine care. In particular, psychological symptoms and support needs for these symptoms were markedly under-recognized. Physical symptoms associated with chemotherapy, such as hair loss, appetite loss and fatigue, were better recognized than symptoms not specific to chemotherapy, such as constipation, insomnia, dyspnea and pain. Oncology nurses' recognition may not accurately reflect their patients' supportive care needs and symptoms in routine practice. In clinical practice, it may be beneficial to conduct routine screening of patients' perceived needs and symptoms comprehensively using self-administered questionnaires.

  20. Yoga Therapy in Japan.

    Science.gov (United States)

    Kimura, Keishin

    2017-11-01

    This perspective piece gives an overview of the current situation of yoga therapy in Japan today. Traditional yoga in Japan suffered a serious setback in 1995 with a nerve gas terrorist attack on the Tokyo subway, which was carried out by a cult that recruited members through yoga classes. But with the increase in popularity with modern forms of yoga such as Iyengar yoga, Ashtanga yoga and hot yoga in the West, the general public in Japan today is forgetting its aversion to yoga and considers it to be something that can contribute to good health. In 2012, the Japan Yoga Therapy Society (JYTS) conducted a study on adverse events in yoga classes throughout Japan with the University of Kyushu School of Medicine, with support from the Ministry of Health, Labour and Welfare. This study indicated that more than half of people attending yoga classes have some form of chronic illness, with 42.3% receiving outpatient care. This survey was the beginning of growing interest from both the government and universities in yoga therapy. JYTS is beginning to make inroads into bringing yoga therapy into cancer and palliative care, senior citizen homes, alcohol and drug addiction rehabilitation, cardiovascular rehabilitation, and research on trauma and schizophrenia. While there are still limited opportunities for yoga therapists to work in mainstream healthcare services, there is growing interest among medical professionals in both physical and mental health. JYTS is beginning to make inroads into bringing yoga therapy into cancer and palliative care, senior citizen homes, alcohol and drug addiction rehabilitation, cardiovascular rehabilitation, and research on trauma and schizophrenia. While there are still limited opportunities for yoga therapists to work in mainstream healthcare services, there is growing interest among medical professionals in both physical and mental health. This perspective piece introduces some of the developments in yoga therapy research and practice in

  1. The internationalization of Japan

    International Nuclear Information System (INIS)

    Kuroki, T.E.

    1989-01-01

    There are growing tensions and frictions between the U.S. and Japan. Among them are science and technology issues that relate to the development of superconductor technology, as well as economic, trade and agricultural issues. The structure of this friction is very complex. There are many interconnected issues that cannot be resolved one by one. This article focuses on the relationship between the U.S. and Japan. Some of the complexities behind the issues are discussed by defining different notions of internationalization and by presenting the positive and negative aspects of the Japanese approach that affects the future cooperation and competition between our nations in the area of superconductivity

  2. Improvement of oral intake following chemotherapy in gastric cancer patients with an inability to eat.

    Science.gov (United States)

    Shitara, Kohei; Ito, Seiji; Sawaki, Akira; Tajika, Masahiro; Kawai, Hiroki; Yokota, Tomoya; Takahari, Daisuke; Ura, Takashi; Muro, Kei

    2010-01-01

    Based on several phase III studies, oral S-1-based chemotherapy has become the standard for treatment of advanced gastric cancer in Japan. However, these studies included patients able to maintain sufficient oral intake, and the effectiveness of chemotherapy for patients unable to eat remained unclear. We retrospectively analyzed the effect of chemotherapy on patients with advanced gastric cancer who presented with inability to eat. We defined 'inability to eat' as requirement for daily intravenous fluids or hyperalimentation and 'improvement of oral intake' as no such requirement >1 week. Among the 777 patients who received first-line chemotherapy, 100 patients (12.8%) were considered unable to eat and required daily intravenous fluids or hyperalimentation. Performance status was 0-1 in 26 patients and ≥ 2 in the other 74 patients. Seventy-eight patients (78%) had peritoneal metastasis and 62 patients (62%) had ascites. First-line chemotherapy with 5-fluorouracil-based regimens was used in 46 patients, taxane-based chemotherapy in 34 patients, oral fluoropyrimidine-based therapy in 19 patients, and irinotecan-cisplatin combination treatment in 2 patients. Median survival time was 5.0 months (95% confidence interval, CI, 3.9-6.6). Improvement in oral intake with duration for >1 week was achieved in 40 patients (40%) with the median duration of nutritional-support-free time of 3.1 months (95% CI 2.5-4.6). Chemotherapy is moderately effective in improving oral intake in patients with advanced gastric cancer with inability to eat. Further study is required to improve its prognosis. Copyright © 2011 S. Karger AG, Basel.

  3. Proceedings of the Japan-U.S. workshop P-118 on vacuum technologies for fusion devices

    International Nuclear Information System (INIS)

    Miyahara, A.

    1989-01-01

    Fusion community does not appreciate vacuum technologies to the same extent as accelerator community does. This is because, in the case of accelerators, in particular storage ring systems, the requirement of attaining ultrahigh vacuum in order to avoid collisional loss is well defined, on the other hand, it is not possible to define the requirement so precisely in the case of fusion devices. One of the reasons is that core plasma interacts with vessel wall so strongly and unpredictably that it becomes difficult to identify the role played by individual components. However, in the next step and the next generation machines like CIT, LHS, ITER, FER and NET, vacuum technologies would play more significant roles, because the CIT will introduce tritium in a vacuum vessel, and the aim of the ITER project is to demonstrate particle balance, namely, to achieve steady state operation with D-T fuel. The Japan-U.S. workshop P-118 was held at the Institute of Plasma Physics, Nagoya University, from August 1 to 5, 1988. 33 participants including 4 from the U.S. took part in the workshop. In the plenary session, 12 lectures were given, and also the topics-oriented session on pumping, gauging, remote maintenance, first wall, pump limiter, divertor and others was held. (K.I.)

  4. Language Testing in Japan.

    Science.gov (United States)

    Brown, James Dean, Ed.; Yamashita, Sayoko Okada, Ed.

    Papers on second language testing in Japan include: "Differences Between Norm-Referenced and Criterion-Referenced Tests" (James Dean Brown); "Criterion-Referenced Test Construction and Evaluation" (Dale T. Griffe); "Behavioral Learning Objectives as an Evaluation Tool" (Judith A. Johnson); "Developing Norm-…

  5. Liquid hydrogen in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Yasumi, S. [Iwatani Corp., Osaka (Japan). Dept. of Overseas Business Development

    2009-07-01

    Japan's Iwatani Corporation has focused its attention on hydrogen as the ultimate energy source in future. Unlike the United States, hydrogen use and delivery in liquid form is extremely limited in the European Union and in Japan. Iwatani Corporation broke through industry stereotypes by creating and building Hydro Edge Co. Ltd., Japan's largest liquid hydrogen plant. It was established in 2006 as a joint venture between Iwatani and Kansai Electric Power Group in Osaka. Hydro Edge is Japan's first combined liquid hydrogen and ASU plant, and is fully operational. Liquid oxygen, liquid nitrogen and liquid argon are separated from air using the cryogenic energy of liquefied natural gas fuel that is used for power generation. Liquid hydrogen is produced efficiently and simultaneously using liquid nitrogen. Approximately 12 times as much hydrogen in liquid form can be transported and supplied as pressurized hydrogen gas. This technology is a significant step forward in the dissemination and expansion of hydrogen in a hydrogen-based economy.

  6. Biomagnetism in Japan.

    Science.gov (United States)

    Kotani, M; Mori, H; Kuriki, S; Uchikawa, Y; Chiyotani, K; Nemoto, I

    1987-01-01

    The study of biomagnetic fields originating in a biological body is called biomagnetism. Among various fields of biomagnetism, this paper reviews the research and clinical works in magnetocardiogram, neuromagnetism, magneto-oculogram, magnetopneumogram and magnetic measurement for cell motility carried out in Japan.

  7. Japan's electronic packaging technologies

    Science.gov (United States)

    Tummala, Rao R.; Pecht, Michael

    1995-01-01

    The JTEC panel found Japan to have significant leadership over the United States in the strategic area of electronic packaging. Many technologies and products once considered the 'heart and soul' of U.S. industry have been lost over the past decades to Japan and other Asian countries. The loss of consumer electronics technologies and products is the most notable of these losses, because electronics is the United States' largest employment sector and is critical for growth businesses in consumer products, computers, automobiles, aerospace, and telecommunications. In the past there was a distinction between consumer and industrial product technologies. While Japan concentrated on the consumer market, the United States dominated the industrial sector. No such distinction is anticipated in the future; the consumer-oriented technologies Japan has dominated are expected to characterize both domains. The future of U.S. competitiveness will, therefore, depend on the ability of the United States to rebuild its technological capabilities in the area of portable electronic packaging.

  8. China, South Korea, Japan

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    Intended for Canadian readers, this popular account was suggested by the Sixth Pacific Basin Nuclear Conference. Economic, political, geographic, sociological and historical aspects of the nuclear programmes of China, South Korea and Japan are discussed. The importance of past, present and future Canadian nuclear trade with the area is indicated

  9. Nuclear Power in Japan.

    Science.gov (United States)

    Powell, John W.

    1983-01-01

    Energy consumption in Japan has grown at a faster rate than in any other major industrial country. To maintain continued prosperity, the government has embarked on a crash program for nuclear power. Current progress and issues/reactions to the plan are discussed. (JN)

  10. Photovoltaics in Japan

    Science.gov (United States)

    Shimada, K.

    1985-01-01

    Report surveys status of research and development on photovoltaics in Japan. Report based on literature searches, private communications, and visits by author to Japanese facilities. Included in survey are Sunshine Project, national program to develop energy sources; industrial development at private firms; and work at academic institutions.

  11. Political Corruption in Japan.

    Science.gov (United States)

    Reed, Steven R.; And Others

    1996-01-01

    Provides an overview of political corruption and its place in Japanese culture and society. Discusses recent scandals and efforts at political reform. These efforts are moving Japan from a "boss-patronage" system to a "civic-culture." Includes a table of post-war Japanese prime ministers and corruption scandals. (MJP)

  12. Japan Report, No. 184.

    Science.gov (United States)

    1983-11-10

    Text] No Progress in "Agricultural" Issue [Moderator] On 7 and 8 July, a 2-day conference of Japanese-U.S. business- men was held at the Ritz ... Carlton Hotel in Chicago; among those attending from Japan was Yoshihiro Inayama, chairman of the Keidanren [federation of economic organizations

  13. Japan's electronic packaging technologies

    Science.gov (United States)

    Tummala, Rao R.; Pecht, Michael

    1995-02-01

    The JTEC panel found Japan to have significant leadership over the United States in the strategic area of electronic packaging. Many technologies and products once considered the 'heart and soul' of U.S. industry have been lost over the past decades to Japan and other Asian countries. The loss of consumer electronics technologies and products is the most notable of these losses, because electronics is the United States' largest employment sector and is critical for growth businesses in consumer products, computers, automobiles, aerospace, and telecommunications. In the past there was a distinction between consumer and industrial product technologies. While Japan concentrated on the consumer market, the United States dominated the industrial sector. No such distinction is anticipated in the future; the consumer-oriented technologies Japan has dominated are expected to characterize both domains. The future of U.S. competitiveness will, therefore, depend on the ability of the United States to rebuild its technological capabilities in the area of portable electronic packaging.

  14. Dutch surgery in Japan

    NARCIS (Netherlands)

    van Gulik, Thomas M.; Nimura, Yuji

    2005-01-01

    An isolation policy was adopted in feudal Japan from 1639 to 1853 owing to the fear of foreign influence. During those 200 years of isolation, all foreigners were withheld from the country with the exception of the Dutch, who were permitted to establish a trading post on a small island in the Bay of

  15. Educational Technology in Japan.

    Science.gov (United States)

    Sakamoto, Takashi

    1987-01-01

    This overview of the current state of educational technology in Japan includes discussions of professional associations; academic and popular journals; diffusion of media and the budget in elementary and secondary schools; recent trends in government policies; educational technology research; a literature review; and suggestions of future trends.…

  16. Higher Education in Japan

    Science.gov (United States)

    Kida, Hiroshi

    1975-01-01

    Describes and quantifies Japan's present state of development of higher education noting the predominance of private establishments, variety of courses available, wide social base from which students are drawn, highly competitive nature of the entry procedures, and the many challenges including the linked problems of management and finance.…

  17. Private Universities in Japan.

    Science.gov (United States)

    Akira, Ninomiya

    The historical development of private universities in Japan is traced, with special attention to the Imperial Ordinance of University of 1918, and postwar developments. The present state of private universities is examined, considering especially their role in national education, finances and financial support, and public support of the…

  18. Chemotherapy

    Science.gov (United States)

    ... cause nerve problems and burning, numbness, tingling, or shooting pain in the fingers and toes. Certain types ... more comfortable wearing hats, scarves, or wigs to school or other events. Or, you may look great ...

  19. Chemotherapy

    Science.gov (United States)

    ... your doctor and your parent say it's OK, get together with your friends and have some fun! Reviewed by: Lisa Wray, ... Kids Cancer Center What Is Cancer? When a Friend Has Cancer Radiation Therapy Some Kinds of Cancer Kids Get Hodgkin Lymphoma When Cancer Keeps You Home View ...

  20. Globalization and Education in Japan

    Science.gov (United States)

    Ohkura, Kentaro; Shibata, Masako

    2009-01-01

    In this paper, the authors contend that globalization in Japan is the gradual process in which Japan's positioning of "self" within international relations, which had formerly been dominated by the West, has changed. Accordingly, Japan's relationships with the West and the rest of the world, for example, Asia, have also been reviewed and…

  1. Nanotechnology for Cancer Therapy Based on Chemotherapy

    OpenAIRE

    Chen-Yang Zhao; Rui Cheng; Zhe Yang; Zhong-Min Tian

    2018-01-01

    Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover,...

  2. Chemotherapy and Cancer - childrens experiences

    OpenAIRE

    Prytz, Anna; Harnfeldt, Linda

    2006-01-01

    With good knowledge about the disease and the treatment, the fear and worry of children and parents can be reduced. Children may be helped by painting to express their experiences. In order to have a good care, the care-personnel need to see and understand what the children need. It is important to live an as regular life as possible during the disease and its treatment. The aim of this study was to elucidate how children experience chemotherapy in conection with their cancer disease. The met...

  3. [Oral complications of chemotherapy of malignant neoplasms].

    Science.gov (United States)

    Obralić, N; Tahmiscija, H; Kobaslija, S; Beslija, S

    1999-01-01

    Function and integrity disorders of the oral cavity fall into the most frequent complication of the chemotherapy of leucemias, malignant lymphomas and solid tumors. Complications associated with cancer chemotherapy can be direct ones, resulting from the toxic action of antineoplastic agents on the proliferative lining of the mouth, or indirect, as a result of myelosuppression and immunosuppression. The most frequent oral complications associated with cancer chemotherapy are mucositis, infection and bleeding. The principles of prevention and management of oral complications during cancer chemotherapy are considered in this paper.

  4. Combined radiotherapy and chemotherapy for head and neck cancer

    International Nuclear Information System (INIS)

    Inuyama, Yukio; Fujii, Masato; Tanaka, Juichi; Takaoka, Tetsuro; Hosoda, Hyonosuke; Kawaura, Mitsuhiro; Toji, Masao

    1988-01-01

    There are 4 modalities of combined radiotherapy and chemotherapy which include (1) concurrent radiotherapy and chemotherapy, (2) sequential use of radiotherapy and chemotherapy (pre-radiation chemotherapy), (3) pre-radiation chemotherapy followed by concurrent radiation and chemotherapy, and (4) alternating use of radiotherapy and chemotherapy based upon Looney's hypothesis. We studied concurrent use of radiotherapy and UFT by means of animal experimentation and clinical trials. The results obtained revealed that UFT was a most suitable agent together with 5-fluorouracil for concurrent application of radiotherapy and chemotherapy. Neo-adjuvant chemotherapy including pre-radiation chemotherapy was also studied in cases of maxillary sinus carcinoma and nasopharyngeal carcinoma. From the results, it seemed desirable to use cisplatin and bleomycin analogs sequentially in combined chemotherapy and radiotherapy. Neo-adjuvant chemotherapy should be studied successively to improve local tumor control rates and prevent distant metastases. For future perspectives, new trials of alternating radiotherapy and chemotherapy based upon Looney's hypothesis seem necessary. (author)

  5. Combined chemotherapy of malignant gliomas

    Energy Technology Data Exchange (ETDEWEB)

    Jellinger, K.; Volc, D.; Grisold, W.; Flament, H.; Vollmer, R.; Weiss, R. (Krankenhaus der Stadt Wien-Lainz (Austria). Ludwig Boltzmann Inst. fuer Neurobiologie)

    1983-01-01

    A controlled study of 226 age-matched patients with histologically proven grade 3 and 4 supratentorial gliomas with maximum feasible tumour resection, postoperative Karnofsky performance over 50 and minimum survival of 8 weeks compares the results of supportive care (45 cases), high-dose irradiation of 40 to 66 Gy (59 cases), COMP protocol (CCNU, procarbazine, vincristine, methotrexate, prednisone in 15 day cycles-42 cases) and simultaneous irradiation and COMP chemotherapy (80 cases including 30 survivors). Median recurrent-free intervals in the treatment groups (7 to 11.7 months) were significantly longer than after supportive care (4.4 months). Median survival with supportive care (6.7 months) was significantly shorter than after radiation or COMP treatment (11.7 and 12.3 months) and 14.9 to over 19.9 months with combined treatment, where the two-year survival rates were 33 and 67% (for survivors), and the 3-year survival rates 13 to 30%. Toxic side effects of multimodality treatment were more frequent than after chemotherapy. In addition to space-occupying intracranial cysts often simulating tumour recurrence (12%) and rare radiation necrosis, about 15% of long-term survivors developed progressive intellectual dysfunction with brain atrophy, in the absence of tumour regrowth. Despite some promising results of multimodality approaches towards the management of malignant supratentorial gliomas, the overall results are unsatisfactory and need further optimization.

  6. [Gambling disorder in Japan].

    Science.gov (United States)

    Tanabe, Hitoshi

    2015-09-01

    Gambling disorder is a psychiatric disorder characterized by persistent and recurrent problematic gambling behavior, associated with impaired functioning, reduced quality of life, and frequent divorce and bankruptcy. Gambling disorder is reclassified in the category Substance-Related and Addictive Disorders in the DSM-5 because its clinical features closely resemble those of substance use disorders, and gambling activates the reward system in brain in much the same way drugs do. Prevalence of gambling disorder in Japan is high rate because of slot machines and pachinko game are very popular in Japan. The author recommend group psychotherapy and self-help group (Gamblers Anonymous), because group dynamics make them accept their wrongdoings related to gambling and believe that they can enjoy their lives without gambling.

  7. Safeguards activities in Japan

    International Nuclear Information System (INIS)

    Osabe, Takeshi

    1998-01-01

    Current Japanese State System for Accountancy and Control (SSAC) has been developing and fully satisfies requirements of both IAEA Safeguards and bilateral partners. However, the public attention on the national and international safeguards activities were increased and the safeguards authorities were required to promote the objective assessment of safeguards implementation to avoid mistrust in safeguards activities which directly influence the public acceptance of nuclear energy in itself. Additionally, since Japan has promoted to complete nuclear fuel cycle including spent fuel reprocessing, enrichment and mixed oxide fuel fabrication this would require further assurance of Japanese non-proliferation commitment. Japan supports the introduction of strengthened safeguards. In this context it is particularly important to strengthen the relationship between national and the IAEA safeguards to contribute actively to the IAEA safeguards in development and utilization of new technologies towards more effective and efficient IAEA safeguards

  8. Moral Education in Japan

    DEFF Research Database (Denmark)

    Roesgaard, Marie Højlund

    ‘religion’ is not a subject in schools. So, how do the Japanese go about the business of teaching values and morality? Using the Japanese example, this volume looks at moral education from the basic point of view of universal and common human values, with due attention given to culture-specific traits....... It places moral education within the context of globalization and cosmopolitanism and shows, that moral education in Japan is a useful key to understanding how globalization and cosmopolitanism can work within a specific system, in this case Japanese values education. In recent years various changes...... values. How are the new requirements and the renewed focus on moral education met in schools and by educators? This volume will describe the history of moral education in Japan, analyse the recent changes of the curriculum, analyse the practices in selected schools via fieldwork and case-studies and take...

  9. Nuclear situation in Japan

    International Nuclear Information System (INIS)

    2006-01-01

    This analysis takes stock on the nuclear situation in Japan. It discusses the ambitious equipment program in collaboration with the France, the destabilization of the japanese nuclear industry following the accidents and the energy policy evolutions. It presents the projects of the japanese nuclear industry: the Monju reactor restart, the Pluthermal project, the reprocessing power plant of Rokkasho Mura, the new reactors, the russian weapons dismantling, the ITER site selection and the buy out of Westinghouse by Toshiba. (A.L.B.)

  10. Fallen star legends and traditional religion of Japan: an aspect of star lore

    Science.gov (United States)

    Goto, Akira

    2015-08-01

    Japanese star lore is a complex mixture of animism, Buddhism, Shinto-ism, Confucianism and folk beliefs. Although some studies have been done on rituals concerning constellation developed in esoteric Buddhism (e.g. Journal Culture and Cosmos, Vol. 10 no 1 and 2), studies on other aspects of Japanese star lore are limited, in particular, to the English audience.In historic literatures, there often mentioned abnormal astronomical phenomena, such as, eclipse, meteors and comets. In this paper, I will discuss the possibility of reference to these astronomical phenomena in order to talk about some historical facts.In western part of Japan, there are Shinto shrines and Buddhistic temples that are said to be built as monuments of fallen stars. Usually fallen stars were divided into three, and a trio of shrines/temples are said to be the remnants of this phenomenon. Similar legends are found in Kudamatsu (that means "fallen pine=pine where stars fallen") of Yamaguchi Prefecture, Bisei-cho (that means "beautiful star") of Okayama Prefecture, Hoshida (that means "rice field or village of star") shrine of Osaka, and also Hoshida shrine of Nagoya.The purpose of this presentation is not to argue whether fallen star legend was truly astronomical phenomenon, such as, meteor or not. Instead, I will discuss why similar legends have been talked concerning the origin of particular shrines or temples. Citing Eliade who related gorge and alchemy producing spark to astronomical phenomena, I will disclose the possibility to relate these astronomical legends to the coming of the naturalized Japanese from Korean Peninsula who introducd forge to Japan abound 5 to 6 centuries.

  11. Comparison of chemotherapy and hematopoietic stem cell ...

    African Journals Online (AJOL)

    Aims: Chemotherapy is frequently used as a conditioning regimen to destroy malignant marrow cells before transplantation. Xerostomia, dysphagia, altered taste perception, mucositis, soft‑tissue ulceration, and infection are common adverse oral effects of chemotherapy. The study was aimed to compare decayed, missing, ...

  12. Experiences of patients undergoing chemotherapy - a qualitative ...

    African Journals Online (AJOL)

    Dealing actively with discomfort and accepting negative impacts in hope of a cure helped the participants manage the acute complications related to the treatment. We recommend the development of interventions to ease discomfort due to chemotherapy. Keywords: Cancer, chemotherapy, experiences, nursing, qualitative ...

  13. Psychology in Japan.

    Science.gov (United States)

    Imada, Hiroshi; Tanaka-Matsumi, Junko

    2016-06-01

    The purpose of this article is to provide information about Japan and its psychology in advance of the 31st International Congress of Psychology (ICP), to be held in Yokohama, Japan, in 2016. The article begins with the introduction of the Japanese Psychological Association (JPA), the hosting organization of the ICP 2016, and the Japanese Union of Psychological Associations consisting of 51 associations/societies, of which the JPA is a member. This is followed by a brief description of a history of psychology of Japan, with emphasis on the variation in our approach to psychology in three different periods, that is, the pre- and post-Pacific War periods, and the post-1960 period. Next, the international contributions of Japanese psychology/psychologists are discussed from the point of view of their visibility. Education and training in psychology in Japanese universities is discussed with a final positive remark about the long-awaited enactment of the Accredited Psychologist Law in September, 2015. © 2016 International Union of Psychological Science.

  14. Japan's fuel recycling policy

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The Atomic Energy Commission (AEC) has formulated Japanese nuclear fuel recycling plan for the next 20 years, based on the idea that the supply and demand of plutonium should be balanced mainly through the utilization of plutonium for LWRs. The plan was approved by AEC, and is to be incorporated in the 'Long term program for development and utilization of nuclear energy' up for revision next year. The report on 'Nuclear fuel recycling in Japan' by the committee is characterized by Japanese nuclear fuel recycling plan and the supply-demand situation for plutonium, the principle of the possession of plutonium not more than the demand in conformity with nuclear nonproliferation attitude, and the establishment of a domestic fabrication system of uranium-plutonium mixed oxide fuel. The total plutonium supply up to 2010 is estimated to be about 85 t, on the other hand, the demand will be 80-90 t. The treatment of plutonium is the key to the recycling and utilization of nuclear fuel. By around 2000, the private sector will commercialize the fabrication of the MOX fuel for LWRs at the annual rate of about 100 t. Commitment to nuclear nonproliferation, future nuclear fuel recycling program in Japan, MOX fuel fabrication system in Japan and so on are reported. (K.I.)

  15. Nanotechnology for Cancer Therapy Based on Chemotherapy.

    Science.gov (United States)

    Zhao, Chen-Yang; Cheng, Rui; Yang, Zhe; Tian, Zhong-Min

    2018-04-04

    Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.

  16. Nanotechnology for Cancer Therapy Based on Chemotherapy

    Directory of Open Access Journals (Sweden)

    Chen-Yang Zhao

    2018-04-01

    Full Text Available Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.

  17. Chemotherapy of metastatic colon cancer

    Directory of Open Access Journals (Sweden)

    M. Yu. Fedyanin

    2012-01-01

    Full Text Available Colorectal cancer is one of the leading causes of cancer incidence and mortality. In 2008 inRussian Federation55 719 new cases of colorectal cancer were diagnosed and 37 911 patients died of this disease. A significant progress was achieved in metastatic colorectal cancer treatment during the last decades. A lot of treatment options became available: from 5-fluoruracil monotherapy to combined treatment treatment schemes including surgery. A group of patients with isolated liver metastases was distinguished, who can achieve 5-year survival rate of 40 % after systemic treatment and surgery. Today, based on clinical data and molecular analysis, we come close to individualized treatment of this patient group. In this literature review results of metastatic colorectal cancer chemotherapy are being analyzed and rational treatment tactic is proposed based on therapy goals. 

  18. Targeting Mechanisms of Resistance to Taxane-Based Chemotherapy

    National Research Council Canada - National Science Library

    Huang, Chung-Yung

    2006-01-01

    .... Further, current clinical, pathological and molecular markers poorly predict the response and resistance of chemotherapy, and the molecular mechanisms of chemotherapy resistance are largely unknown...

  19. Targeting Mechanisms of Resistance to Taxane-Based Chemotherapy

    National Research Council Canada - National Science Library

    Huang, Chung-Ying

    2007-01-01

    .... Further current clinical pathological and molecular markers poorly predict the response and resistance of chemotherapy and the molecular mechanisms of chemotherapy resistance are largely unknown...

  20. [Risk factor for lifestyle and way of living for symptoms of sick building syndrome: epidemiological survey in Japan].

    Science.gov (United States)

    Nakayama, Kunio; Morimoto, Kanehisa

    2009-05-01

    To investigate the association among symptoms of sick building syndrome (SBS). Self-reported questionnaire and indoor environmental surveys of newly build dwellings in Japan were conducted. The questionnaire included items on symptoms of SBS and lifestyle, and an indoor environmental survey (i.e., mold, mites, and volatile organic compounds (VOC)) was conducted in family rooms of dwellings in Japan (Sapporo, Fukushima, Nagoya, Osaka, Okayama, and Kitakyusyu), from 2004 to 2007. Data from Osaka in 2004 indicated significant odds ratios for symptoms of SBS for questionnaire items on renovation, air freshener, carpet, use of benzin, use of thinner, use of coating materials, moldiness, smell of house, and feeling of having insufficient sleeping hours. Significant odds ratios were noted for total CFU, Auerbasidum genus, Alternaria alternata, Aspergillus sp., Aureobasidium pullulans, Cladosporium cladosporioides, Fusarium sp., Penicillium sp., Rhodotorula minuta, and Wallemia sebi. Concerning concentrations of VOCs, TVOC, limonene, o,m-tolualdehyde, 2-pentanone, tetrachloroethylene, n-decane, and n-heptane are significantly higher in those who have symptoms of SBS. Significant odds ratios were indicated for questionnaire items on smell of house, stuffiness, moldiness, fustiness, dampness, water leakage, and feeling of having insufficient sleeping hours from data of six areas in Japan in 2004. Continuous data analysis of Osaka from 2004 to 2006 suggested that improvement of symptoms of SBS might be due to lifestyle modification. Mites, molds, VOCs, renovation, moldiness, stuffiness, feeling of having insufficient sleeping hours, carpet use, benzin, thinner, and coating materials, increase the risk of developing symptoms of SBS, whereas modification of lifestyle and ways of living factors might alleviate them.

  1. JPRS Report, Science & Technology, Japan

    Science.gov (United States)

    1988-10-05

    This is Japan Report with Science and Technology. It contains the issues with different topics on biotecnology , defense industry, nuclear engineering, Marine technology, science and technology policy.

  2. The graying of Japan.

    Science.gov (United States)

    Martin, L G

    1989-07-01

    Japan's rapidly aging population has become a top policy issue, especially as the increasing costs of pensions and medical care are debated. With the highest life expectancy on earth, the Japanese potentially face long periods of retirement, as well as the possibility of long periods of disability. Although family support of the elderly is thought to have been strong traditionally, the recent decline in co-residence with children is 1 indication that the way support is given may be changing. This issue is of particular concern to the government, which wants to avoid any greater responsibility for the elderly than is necessary given the dramatic population aging yet to come. The government is also encouraging employers to provide more employment opportunities for the elderly at the same time that it is trying to raise the eligibility age for the receipt of public pensions. There is resistance on the part of employers, however, because wages and retirement allowances in Japan are positively related to length of employment. Furthermore, it is not clear whether elderly Japanese of the future will be as willing to work, if they learn to enjoy increased leisure early in their careers. Nevertheless, it is unlikely that population aging will lead to Japan's economic decline. Although the savings rate may decline somewhat, restructuring of the economy and continued overseas investment should keep the economy growing in the long run. Important in both the care of the frail elderly and the continued growth of the economy will be the roles played by middle-aged Japanese women.

  3. Holography In Japan

    Science.gov (United States)

    Tsujiuchi, Jumpei

    1985-08-01

    The present status of activities of research and application of holography in Japan is reviewed. The most active field is metrology, and many applications in automobile, aircraft, electronic industries as well as basic researches are found. Information processing and optical memory are still in laboratory level, and suitable applications are looked for. Optical elements are promising, and applications in POS scanning systems are already in practical use. Applications in 3-D image display are spreading among the public, and applications for medical purpose have started. Acoustical holography is applied in mechanical engineering, and electron holography becomes a very attractive tool for experimental physics.

  4. Skiing research in Japan.

    Science.gov (United States)

    Watanabe, K

    1981-01-01

    Skiing and skiing techniques were introduced by the Austrians to Japanese soldiers in 1911. After that, skiing spread beyond the original purpose and recently produced the ski sciences. From a sports biomechanical aspect, the development of the study of ski jumping, alpine skiing, and the basic movement in skiing is introduced in this paper. One of the characteristic points of these studies in Japan was that the ski sciences were supported not only by biomechanists and physiologists, but also basically by physicists and engineers. The fundamental research and studies from divergent fields are supporting each other and being integrated into ski science.

  5. Nyheder i Japan

    DEFF Research Database (Denmark)

    Sejrup, Jens

    2016-01-01

    Kan man stole på, hvad folk siger, når man ikke ved, hvem de er? Forholdet mellem kildeanonymitet og troværdighed er forskelligt i mediesystemer rundt om i verden. Troværdighed er ingen universel størrelse, men en retorisk effekt der opstår på baggrund af faktorer som er kulturelt og systemisk in...... indlejret. I Japan har seriøse nyhedsmedier et specielt forhold til udsagn fra anonyme kilder, og udstrakt brug af uidentificerede informanter står ikke i modsætning til journalistisk kvalitet og pålidelighed....

  6. Domestic violence in Japan.

    Science.gov (United States)

    Kozu, J

    1999-01-01

    Traditionally, domestic violence in Japan referred to children's physical and emotional violence against their parents. However, in recent years, the general public's awareness of and actions toward other types of domestic violence, especially violence against women and children, has increased. Following a brief description of filial violence and elderly abuse, both spousal abuse and child abuse are discussed in terms of their prevalence and cultural and historical backgrounds. The article concludes with current and future challenges in the intervention of violence, particularly against women and children, in the Japanese family.

  7. Nuclear services for Japan

    International Nuclear Information System (INIS)

    Anderson, B.

    1991-01-01

    The UK Atomic Energy Authority (UKAEA) became AEA Technology in April 1990. The commercial interests are focussed through 4 business units: AEA Reactor Services, with whom several contracts have been won from Japanese customers for high resolution Field Emission Gun Scanning Transmission Electron Microscopy (FEGSTEM); AEA Fuel Services, a contract is being negotiated with an existing Japanese customer; AEA Decommissioning and Radwaste, with whom further development of an alternative approach to evaporation of liquid waste effluent for specific application in Japan is in progress; AEA Fusion. 1 fig

  8. Patient expectancy and post-chemotherapy nausea

    DEFF Research Database (Denmark)

    Colagiuri, Ben; Zachariae, Robert

    2010-01-01

    to determine the strength of the relationship between expectancy and post-chemotherapy nausea. METHODS: The findings from 17 relevant studies (n = 2,400) identified through systematic searches of Medline, PsycInfo, and Cinhal were analyzed using a combination of meta-analytic techniques. RESULTS: Overall......, there was a robust positive association between expectancy and post-chemotherapy nausea (ESr = 0.18, equivalent to Cohen's d = 0.35), suggesting that patients with stronger expectancies experience more chemotherapy-induced nausea. Although weaker associations were found in studies employing multivariate analysis...

  9. Construction. A Report on the Industry

    Science.gov (United States)

    2004-06-01

    the high-speed MAGLEV magnetic train system linking Shanghai and the new international airport. Private investment is so prevalent in Shanghai that...Thailand Laem Chabang Port Authority, Laem Chabanf, Thailand CENTRAIR (Central Japan International Airport), Nagoya, Japan Bullet Train ...Tokyo to Nagoya, Japan Yokuska Naval Base, Yokuska, Japan Army Corps of Engineers, Japan District, Yokuska, Japan Maglev transit system, Shanghai

  10. Food irradiation in Japan

    International Nuclear Information System (INIS)

    Ito, Hitoshi

    1995-01-01

    The basic research on food irradiation in Japan was begun around 1955 by universities and national laboratories. In 1967, food irradiation was designated to the specific general research on atomic energy, and the national project on large scale was continued until 1983. As the result, the treatment of germination prevention for potatoes was approved by the Ministry of Health and Welfare in 1972. The Co-60 gamma ray irradiation facility of Shihoro Agricultural Cooperative is famous as the facility that succeeded in the practical use of food irradiation for the first time in the world. But the practical use of food irradiation stagnates and the research activities were reduced in Japan due to the circumstances thereafter. The effect of radiation to foods and living things is explained. The features of the radiation treatment of foods are small temperature rise, large transmissivity, no residue, the small loss of nutrition and large quantity, continuous treatment. The safety of irradiated foods is explained. The subjects for hereafter are discussed. (K.I.)

  11. Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Herbst, Christine; Rehan, Fareed Ahmed; Skoetz, Nicole

    2011-01-01

    BACKGROUND: Combined modality treatment (CMT) consisting of chemotherapy followed by localised radiotherapy is standard treatment for patients with early stage Hodgkin lymphoma (HL). However, due to long term adverse effects such as secondary malignancies, the role of radiotherapy has been...... questioned recently and some clinical study groups advocate chemotherapy only for this indication. OBJECTIVES: We performed a systematic review with meta-analysis of randomised controlled trials (RCTs) comparing chemotherapy alone with CMT in patients with early stage Hodgkin lymphoma with respect...

  12. Safety Concerns of Tourism Business in Japan

    Directory of Open Access Journals (Sweden)

    Irina P. Karavaeva

    2012-05-01

    Full Text Available The article is focused on the current state of tourism industry in Japan after the nuclear disaster of 2011. A focus is made on networking activities of Japan Government aimed at boosting leisure travel flows to Japan.

  13. Managing Chemotherapy Side Effects: Hair Loss (Alopecia)

    Science.gov (United States)

    ... C ancer I nstitute Managing Chemotherapy Side Effects Hair Loss (Alopecia) “Losing my hair was hard at first. Then ... and anywhere on your body may fall out. Hair loss is called alopecia. When will my hair start ...

  14. Novel Combination Chemotherapy for Localized Ewing Sarcoma

    Science.gov (United States)

    In this clinical trial, researchers will test whether the addition of the drug combination vincristine, topotecan, and cyclophosphamide to a standard chemotherapy regimen improves overall survival in patients with extracranial Ewing

  15. Managing Chemotherapy Side Effects: Memory Changes

    Science.gov (United States)

    N ational C ancer I nstitute Managing Chemotherapy Side Effects Memory Changes What is causing these changes? Your doctor will work to find out what is causing these problems. They may be caused by ...

  16. Cancer chemotherapy and biotherapy: principles and practice

    National Research Council Canada - National Science Library

    Chabner, Bruce; Longo, Dan L

    2011-01-01

    "Updated to include the newest drugs and those currently in development, Cancer Chemotherapy and Biotherapy, Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents...

  17. Higher Education Studies in Japan

    Science.gov (United States)

    Kaneko, Motohisa

    2010-01-01

    The rapid development of higher education in the postwar period has given rise to various problems, and higher education studies in Japan have developed in response to them. What have been the major issues, and how did academic research respond to them, in postwar Japan? This article delineates an outline of higher education studies in general,…

  18. Hepatocellular carcinoma (HCC): beyond sorafenib-chemotherapy.

    Science.gov (United States)

    Kim, Dae Won; Talati, Chetasi; Kim, Richard

    2017-04-01

    Hepatocellular carcinoma (HCC) is the most common primary liver cancer with poor prognosis. The incidence of HCC and HCC-related deaths have increased over the last several decades. However, the treatment options for advanced HCC are very limited. Sorafenib remains the only drug approved for systemic treatment for advanced HCC. However, prior to sorafenib era conventional cytotoxic chemotherapies have been studied in advanced HCC. In this review, clinical studies of systemic chemotherapy for advanced HCC will be summarized and discussed.

  19. Hepatocellular carcinoma (HCC): beyond sorafenib—chemotherapy

    OpenAIRE

    Kim, Dae Won; Talati, Chetasi; Kim, Richard

    2017-01-01

    Hepatocellular carcinoma (HCC) is the most common primary liver cancer with poor prognosis. The incidence of HCC and HCC-related deaths have increased over the last several decades. However, the treatment options for advanced HCC are very limited. Sorafenib remains the only drug approved for systemic treatment for advanced HCC. However, prior to sorafenib era conventional cytotoxic chemotherapies have been studied in advanced HCC. In this review, clinical studies of systemic chemotherapy for ...

  20. Mechanisms of chemotherapy-induced behavioral toxicities

    Directory of Open Access Journals (Sweden)

    Elisabeth G Vichaya

    2015-04-01

    Full Text Available While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms of chemotherapy include (i cognitive deficiencies such as problems with attention, memory and executive functioning; (ii fatigue and motivational deficit; and (iii neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of life. Little is known about the underlying mechanisms responsible for the development of these behavioral toxicities, however, neuroinflammation is widely considered to be one of the major mechanisms responsible for chemotherapy-induced symptoms. Here, we critically assess what is known in regards to the role of neuroinflammation in chemotherapy-induced symptoms. We also argue that, based on the available evidence neuroinflammation is unlikely the only mechanism involved in the pathogenesis of chemotherapy-induced behavioral toxicities. We evaluate two other putative candidate mechanisms. To this end we discuss the mediating role of damage-associated molecular patterns (DAMPs activated in response to chemotherapy-induced cellular damage. We also review the literature with respect to possible alternative mechanisms such as a chemotherapy-induced change in the bioenergetic status of the tissue involving changes in mitochondrial function in relation to chemotherapy-induced behavioral toxicities. Understanding the mechanisms that underlie the emergence of fatigue, neuropathy, and cognitive difficulties is vital to better treatment and long-term survival of cancer patients.

  1. 21 CFR 186.1555 - Japan wax.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Japan wax. 186.1555 Section 186.1555 Food and Drugs... Substances Affirmed as GRAS § 186.1555 Japan wax. (a) Japan wax (CAS Reg. No. 8001-39-6), also known as Japan... fruits of the oriental sumac, Rhus succedanea (Japan, Taiwan, and Indo-China), R. vernicifera (Japan...

  2. Spent fuel management in Japan

    International Nuclear Information System (INIS)

    Shirahashi, K.; Maeda, M.; Nakai, T.

    1996-01-01

    Japan has scarce energy resources and depends on foreign resources for 84% of its energy needs. Therefore, Japan has made efforts to utilize nuclear power as a key energy source since mid-1950's. Today, the nuclear energy produced from 49 nuclear power plants is responsible for about 31% of Japan's total electricity supply. The cumulative amount of spent fuel generated as of March 1995 was about 11,600 Mg U. Japan's policy of spent fuel management is to reprocess spent nuclear fuel and recycle recovered plutonium and uranium as nuclear fuel. The Tokai reprocessing plant continues stable operation keeping the annual treatment capacity or around 90 Mg U. A commercial reprocessing plant is under construction at Rokkasho, northern part of Japan. Although FBR is the principal reactor to use plutonium, LWR will be a major power source for some time and recycling of the fuel in LWRs will be prompted. (author). 3 figs

  3. Impact of adjuvant chemotherapy for gliomatosis cerebri

    International Nuclear Information System (INIS)

    Kong, Doo-Sik; Nam, Do-Hyun; Kim, Sung Tae; Lee, Jung-Il; Suh, Yeon-Lim; Lim, Do Hoon; Kim, Won Seog; Kwon, Ki-Hoon; Park, Kwan; Kim, Jong Hyun

    2010-01-01

    Gliomatosis cerebri (GC) is characterized by a diffuse infiltration of tumor cells throughout CNS, however, few details are available about the chemotherapeutic effect on GC. The aim of this study was to investigate its clinical course and to determine the efficacy of chemotherapy for GC. Between Jan. 1999 and Dec. 2004, 37 GC patients were diagnosed by biopsy and treated with radiotherapy in a single institution. To determine the efficacy of chemotherapy for GC, we retrospectively reviewed their clinical courses. The study cohort was divided into 2 groups, those with and without receiving post-radiotherapy adjuvant chemotherapy such as temozolomide or nitrosourea-based chemotherapy. Nineteen patients with adjuvant chemotherapy were assigned to the chemotreatment group and 18 with radiotherapy alone were assigned to the control group. Mean survival for chemotreatment group and control group were 24.2 and 13.1 months, respectively (p = 0.045). Time to progression for these groups were 16.0 and 6.0 months, respectively (p = 0.007). Overall review of the clinical course of patients with GC provided that early appearance of new contrast-enhancing lesions within 6 months from the initial diagnosis and higher histological grade were closely associated with poor survival (p < 0.001 and p = 0.008). Adjuvant chemotherapy following radiotherapy could prolong the survival in patients with GC. In addition, newly developed contrast-enhanced lesions on the follow-up MR images indicate the progression of GC

  4. Metronomic palliative chemotherapy in maxillary sinus tumor

    Directory of Open Access Journals (Sweden)

    Vijay M Patil

    2016-01-01

    Full Text Available Background: Metronomic chemotherapy consisting of methotrexate and celecoxib recently has shown promising results in multiple studies in head and neck cancers. However, these studies have not included patients with maxillary sinus primaries. Hence, the role of palliative metronomic chemotherapy in patients with maxillary sinus carcinoma that is not amenable to radical therapy is unknown. Methods: This was a retrospective analysis of carcinoma maxillary sinus patients who received palliative metronomic chemotherapy between August 2011 and August 2014. The demographic details, symptomatology, previous treatment details, indication for palliative chemotherapy, response to therapy, and overall survival (OS details were extracted. SPSS version 16 was used for analysis. Descriptive statistics have been performed. Survival analysis was done by Kaplan-Meier method. Results: Five patients had received metronomic chemotherapy. The median age was 60 years (range 37-64 years. The proportion of patients surviving at 6 months, 12 months, and 18 months were 40%, 40%, and 20%, respectively. The estimated median OS was 126 days (95% confidence interval 0-299.9 days. The estimated median survival in patients with an event-free period after the last therapy of <6 months was 45 days, whereas it was 409 days in patients with an event-free period postlast therapy above 6 months (P = 0.063. Conclusion: Metronomic chemotherapy in carcinoma maxillary sinus holds promise. It has activity similar to that seen in head and neck cancers and needs to be evaluated further in a larger cohort of patients.

  5. Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port

    Directory of Open Access Journals (Sweden)

    Paul H. Sugarbaker

    2012-01-01

    Full Text Available Cytoreductive surgery (CRS and hyperthermic intraperitoneal chemotherapy (HIPEC have been established as treatment options for patients with peritoneal metastases or peritoneal mesothelioma. However, this novel treatment strategy remains associated with a large percentage of local-regional treatment failures. These treatment failures are attributed to the inadequacy of HIPEC to maintain a surgical complete response. Management strategies to supplement CRS and HIPEC are indicated. A simplified approach to the intraoperative placement of an intraperitoneal port for adjuvant bidirectional chemotherapy (ABC was devised. Four different chemotherapy treatment plans were utilized depending upon the primary site of the malignancy. Thirty-one consecutive patients with an intraoperative placement of the intraperitoneal port were available for study. The incidence of adverse events that caused an early discontinuation of the bidirectional chemotherapy occurred in 75% of the 8 patients who had an incomplete cytoreduction and in 0% of patients who had a complete cytoreduction. All of the patients who had complete cytoreduction completed at least 5 of the scheduled 6 bidirectional chemotherapy treatments. Adjuvant bidirectional chemotherapy is possible following a major cytoreductive surgical procedure using a simplified method of intraoperative intraperitoneal port placement.

  6. Current therapeutic strategies for anal squamous cell carcinoma in Japan

    International Nuclear Information System (INIS)

    Takashima, Atsuo; Shimada, Yasuhiro; Hamaguchi, Tetsuya

    2009-01-01

    In Western countries, chemoradiotherapy (CRT) is well established as the standard therapy for stages II/III anal squamous cell carcinoma (ASCC). In Japan, the therapeutic modalities for and outcomes of this disease have not been clarified because ASCC is quite rare. The Colorectal Cancer Study Group of the Japan Clinical Oncology Group (JCOG-CCSG) conducted a survey to determine the current therapeutic strategies for ASCC in Japan. In July 2006, a questionnaire was sent to 49 institutions affiliated with the JCOG-CCSG to gather information on numbers of cases, therapeutic modalities, and outcomes. The target subjects were patients with stages II/III ASCC, diagnosed from January 2000 to December 2004, who were 20-80 years of age with normal major organ function and no severe complications. Replies were received from 40 institutions. A total of 59 patients satisfied the subject criteria. Detailed information was obtained for 55 subjects; 25 (45%) had stage II ASCC and 30 (55%) had stage III ASCC. CRT was performed in 25 patients (45%); surgery in 17 (31%); surgery combined with radiotherapy (RT), chemotherapy, or CRT in 8 (15%); and RT in 5 (9%). Complete response rate in CRT was 80% (20/25). The 3-year progression-free survival rates for all subjects and for CRT-only subjects were 67% and 77%, respectively. From 2000 to 2004, only 59 patients with ASCC were identified in the JCOG-CCSG survey and about half of them underwent CRT. (author)

  7. Japan and the global environment

    International Nuclear Information System (INIS)

    Miller, A.S.; Moore, C.

    1993-01-01

    In many areas, the word most often used to describe Japanese policy is open-quotes enigma.close quotes In some ways, Japan's record on environmental policy also has elements of mystery and contradiction. On the one hand, Japan's history and culture often are associated with a reverence for nature. Indeed, Japan does lead the world in certain environmental areas, such as reduction of conventional air pollutants and compensation of air pollution victims. On the other hand, Japan has been widely criticized for its poor record in preserving its domestic environment, contribution to tropical deforestation, and unwillingness to protect endangered species. Today, the international community clamors for Japan to take its share of responsibility, as an economic superpower, for the global environment. To secure its place in world affairs, Japan slowly has begun to respond to this pressure on issues ranging from ivory importation to reduction of CFC emissions. There is some hope that the government's particular willingness to address global warming may be a sign of significant changes to come in Japanese environmental policy. However, international pressure remains on the many environmental issues Japan has yet to resolve, including tropical deforestation and financing of Third World development projects that harm the environment. Japan's environmental policy is most effective when government and industry cooperate to find technical solutions to environmental problems. Although in recent years Japan's energy consumption has risen sharply, the Japanese have developed numerous technologies to reduce pollution and increase economic growth by improving energy efficiency. It is in these technologies that Japan has made the greatest strides and has the most to offer the global environment

  8. Summary report on the Japan-US workshop on the assessment of spectroscopic data for temperature and density measurements

    International Nuclear Information System (INIS)

    Wiese, W.L.; Fujita, J.

    1988-03-01

    This workshop was held as a part of the US-Japan Cooperative Fusion Program 1986 at the Institute of Plasma Physics, Nagoya University, on March 18 - 20, 1987. Talks were carried out on the following plasma diagnostic subjects, giving special consideration to the situation of spectroscopic data and the needs, availability and adequacy of the data: x-ray spectroscopy, VUV and visible region spectroscopy, plasma edge spectroscopy, polarization spectroscopy, charge exchange spectroscopy, excitation rate data, and spectral radiometry and spectroscopic data tables. The program of the workshop and the abstracts of the talks are given in the first part of this summary report. On the last day of the workshop, small groups were formed, which deliberated on the situation of spectroscopic data in the various diagnostic areas, and especially focused on the further needs of the data. The summary of the findings and recommendation are given in the second part. The workshop was attended by five US and 25 Japanese scientists, and greatly benefitted from the active participation of three quests. (Kako, I.)

  9. Activity in SRL Nagoya Coated Conductor Center for YBCO Coated Conductor by IBAD+ PLD Method -Long, high Ic conductor and a new bamboo-like nanostructure for efficient pinning

    International Nuclear Information System (INIS)

    Yamada, Yutaka; Ibi, Akira; Fukushima, Hiroyuki; Kuriki, Reiji; Takahashi, Kazuhiro; Kobayashi, Hiroyoshi; Ishida, Satoru; Konishi, Masaya; Miyata, Seiki; Watanabe, Tomonori; Kato, Takeharu; Hirayama, Tsukasa; Shiohara, Yuh

    2006-01-01

    In SRL-Nagoya Coated Conductor Center (NCCC), long buffered substrate tapes and YBCO coated conductors have been successfully fabricated by using ion-beam assisted deposition (IBAD) and pulsed laser deposition (PLD) methods. For the buffered tape, the PLD-CeO2 method, what we call the 'Self-Epitaxial' method, realized the high degree of in-plane texturing around 4 degrees along the length of 220 m. For YBCO deposition, we have recently introduced new reel-to-reel PLD equipment with a multi-plume and multi-turn deposition system (MPMT PLD). This system succeeded in fabricating a long coated conductor with a high critical current, Ic, of 245 A and length of 212 m. Ic xL (length) reached the world record of 51940 Am. Furthermore, the introduction of artificial pinning center and RE 123 materials were also studied for improving flux pinning and enhancing Ic. A new columnar structure of the 'bamboo structure' (BaZrO3/Y123 layer-stacked structure) was found in Y123+YSZ sample. This columnar structure and the stacking faults in Gd123 were found to be effective for enhancing pinning properties. Using these techniques, we have succeeded in increasing Ic at 0 T to 480 A/cm and also enhancing Ic in a magnetic field

  10. Safety regulations in Japan

    International Nuclear Information System (INIS)

    Kondo, S.

    1987-01-01

    In Japan, it is provided in the Law for Regulations of Nuclear Source Material, Nuclear Fuel Material and Reactors (referred as LRNR) that the licensee shall establish the safety regulations for individual plant by themselves regarding the operating management of nuclear reactor facility to secure the concrete safety of the nuclear power plant, that he shall receive an authorization of responsible government agencies (Minister of International Trade and Industry for commercial power station) and that this regulation shall be kept by the licensee and its employees. Furthermore, it is also provided in the same law that the licensee shall voluntarily nominate a chief reactor engineer to supervise the safety of reactor operation and that those who are engaged to the reactor operation shall obey the chief reactor engineer's instruction for the safety of reactor operation. These two factors are the base of the voluntary security system for reactor safety

  11. Radiation processing in Japan

    International Nuclear Information System (INIS)

    Makuuchi, Keizo

    2001-01-01

    Economic scale of radiation application in the field of industry, agriculture and medicine in Japan in 1997 was investigated to compare its economic impacts with that of nuclear energy industry. Total production value of radiation application accounted for 54% of nuclear industry including nuclear energy industry and radiation applications in three fields above. Industrial radiation applications were further divided into five groups, namely nondestructive test, RI instruments, radiation facilities, radiation processing and ion beam processing. More than 70% of the total production value was brought about by ion beam processing for use with IC and semiconductors. Future economic prospect of radiation processing of polymers, for example cross-linking, EB curing, graft polymerization and degradation, is reviewed. Particular attention was paid to radiation vulcanization of natural rubber latex and also to degradation of natural polymers. (S. Ohno)

  12. Adapting immunisation schedules for children undergoing chemotherapy.

    Science.gov (United States)

    Fernández-Prada, María; Rodríguez-Martínez, María; García-García, Rebeca; García-Corte, María Dolores; Martínez-Ortega, Carmen

    2018-02-01

    Children undergoing chemotherapy for cancer have special vaccination needs after completion of the treatment. The aim of this study was to evaluate the adaptation of post-chemotherapy vaccination schedules. An observational study was performed on a retrospective cohort that included all children aged from 0 to 14 years, who completed chemotherapy in a tertiary hospital between 2009 and 2015. Inclusion and exclusion criteria were applied. Immunisation was administered in accordance with the guidelines of the Vaccine Advisory Committee of the Spanish Association of Paediatrics. Primary Care immunisation and clinical records of the Preventive Medicine and Public Health Department were reviewed. Of the 99 children who had received chemotherapy, 51 (70.6% males) were included in the study. As regards the type of tumour, 54.9% had a solid organ tumour, and 45.1% had a haematological tumour. Post-chemotherapy immunisation was administered to 70.6%. The most common vaccines received were: diphtheria-tetanus-pertussis or diphtheria-tetanus (54.9%), meningococcus C (41.2%), and seasonal influenza (39.2%). The rate of adaptation of the immunisation schedule after chemotherapy was 9.8%. The pneumococcal conjugate vaccine against 7v or 13v was administered to 21.6% of study subjects. However, only 17.6% received polysaccharide 23v. None received vaccination against hepatitis A. No statistically significant differences were observed between adherence to immunisation schedules and type of tumour (P=.066), gender (P=.304), or age (P=.342). Post-chemotherapy immunisation of children with cancer is poor. The participation of health professionals in training programs and referral of paediatric cancer patients to Vaccine Units could improve the rate of schedule adaptation and proper immunisation of this population. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  13. The Cogema group in Japan

    International Nuclear Information System (INIS)

    1998-12-01

    The partnership between the Cogema group and Japan in the domain of fuel cycle started about 20 years ago and the 10 Japanese nuclear operators are all clients of the Cogema group. The 1997 turnover realized with Japan reached 3.6 billions of francs (11% of the total turnover of the group). This short paper presents briefly the nuclear program of Japan (nuclear park, spent fuels reprocessing-recycling strategy) and the contracts between Cogema and the Japanese nuclear operators (natural uranium, uranium conversion and enrichment, spent fuel reprocessing, plutonium recycle and MOX fuel production markets). (J.S.)

  14. Positioning Indian Emigration to Japan

    DEFF Research Database (Denmark)

    D'Costa, Anthony

    2013-01-01

    that act as significant barriers to the entry of foreign skilled professionals. The paper brings out the source and pattern of foreign professionals and students in Japan as a proxy for talent. Though India’s presence in Japan is currently limited, its share of technical professionals to the total number...... as other IT-strong developing countries, are to supply technical talent, whose availability in Japan is constrained by the secular demographic crisis and changing educational and occupational preferences. The challenges for India are the institutional barriers, in particular, Japanese business practices...

  15. Synovial sarcoma of the maxillary sinus: an extremely rare case with excellent response to chemotherapy

    Directory of Open Access Journals (Sweden)

    Saito S

    2018-01-01

    Full Text Available Shin Saito,1 Hiroyuki Ozawa,1 Yuuichi Ikari,1 Nana Nakahara,1 Fumihiro Ito,2 Mariko Sekimizu,1 Junichi Fukada,3 Kaori Kameyama,4 Kaoru Ogawa1 1Department of Otorhinolaryngology – Head and Neck Surgery, Keio University, School of Medicine, 2Department of Otorhinolaryngology – Head and Neck Surgery, NHO Tokyo Medical Center, 3Department of Radiology, 4Department of Pathology, Keio University, School of Medicine, Tokyo, Japan Abstract: This paper presents an extremely rare case of synovial sarcoma arising from the maxillary sinus, which resulted in a clinically complete response to chemotherapy. Synovial sarcoma is a rare soft tissue malignant tumor, most commonly affecting the extremities. While ~10% occur in the head and neck region, synovial sarcoma of the sinonasal tract is extremely rare, with only 11 cases having been reported previously. As with other sarcomas, the standard treatment is complete resection while allowing for a safe margin, but this is often difficult in the head and neck area due to the complicated anatomy there. This makes the treatment of head and neck sarcoma challenging and leads to the need for a multimodal approach in advanced cases. However, the exact efficacy of chemotherapy is not well understood. In this report, we present a case of unresectable maxillary sinus synovial sarcoma that was successfully treated by chemotherapy followed by radiation therapy. A 53-year-old Japanese man was referred to our hospital with a history of left nose obstruction over the previous couple of years. Computed tomography/magnetic resonance imaging revealed a tumor arising from the maxillary sinus that extended to adjacent tissues. A biopsy was performed, and the tumor was diagnosed as synovial sarcoma. Since the tumor was unresectable, neoadjuvant chemotherapy was administered. The response was excellent, and the tumor became undetectable under endoscopy and radiological imaging. This provided us with a clinical evaluation of

  16. Administering chemotherapy in nononcology settings: a case study.

    Science.gov (United States)

    Smith, Nancy

    2011-08-01

    Providing chemotherapy for patients in a variety of settings may be a challenge for oncology nurses. Increased acuity and comorbidities of patients needing chemotherapy have resulted in a greater incidence of administration in nononcology settings, such as intensive care units (ICUs). In addition, patients with conditions other than cancer are receiving chemotherapy. Because of a lack of certified and experienced chemotherapy nurses in the ICU, oncology nurses may be pulled from their unit to administer chemotherapy. Another possibility is that nonchemotherapy-certified nurses may be asked to administer chemotherapy. Caring for patients receiving chemotherapy may be stressful for nononcology nurses because of their lack of knowledge regarding chemotherapy precautions and the management of side effects and toxicities. Not only is coordination and cooperation between nursing personnel vital, certified oncology nurses must be able to assess the situation, provide the necessary information and education, and safely administer the chemotherapy. This article describes a case study and provides suggestions for planning in similar situations.

  17. Can wolves help save Japan's mountain forests?

    Science.gov (United States)

    Barber-meyer, Shannon

    2017-01-01

    Japan’s wolves were extinct by 1905. Today Japan's mountain forests are being killed by overabundant sika deer and wild boars. Since the early 1990s, the Japan Wolf Association has proposed wolf reintroduction to Japan to restore rural ecology and to return a culturally important animal. In this article I discuss whether the return of wolves could help save Japan's mountain forests.

  18. Contraception in Japan: Current trends.

    Science.gov (United States)

    Yoshida, Honami; Sakamoto, Haruka; Leslie, Asuka; Takahashi, Osamu; Tsuboi, Satoshi; Kitamura, Kunio

    2016-06-01

    High proportion of Japanese uses condoms; lower proportion uses oral contraceptive pills (OCPs). We examined the longitudinal patterns for contraceptive usage in Japan and evaluated differences before and after OCP government approval. We accessed nationally representative survey data for women aged 16-49years from 1950 to 2014. Usage of condoms and OCP was 83.4% and 3.0%, respectively in 2014. OCP use before (1.21%) and after (1.97%) government approval did not differ significantly (p=.58). The prevalence of OCP usage remains low in Japan. A wide gap in use between Japan and other developed countries exists. Through a wide gap in OCP use between Japan and other countries, we revealed how choices of contraceptive methods and their benefits could be openly available for women of reproductive age, and how health care professionals disseminate appropriate knowledge about contraception for women in need. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Nuclear power development in Japan

    International Nuclear Information System (INIS)

    Sugawara, A.

    1994-01-01

    The energy situation in Japan is briefly outlined. Vulnerability in energy structure of the country is shown by a comparison of primary energy supply patterns of Japan and Western countries. Japan's energy policy consists in reducing dependence on oil, promoting efficient use of energy and increasing use of non-fossil fuels. Nuclear power is a core of alternative energy for petroleum because of stable supply of nuclear fuel, low detrimental emissions and less dependence on the fuel. A short historical review of nuclear power development in Japan is presented. Some future issues as development of entire nuclear fuel cycle, social acceptance, reactor safety and nuclear power economics are also discussed. 6 figs. (R.T.)

  20. Radioactivity survey data in Japan

    International Nuclear Information System (INIS)

    1981-06-01

    Strontium-90 and cesium-137 in Japan were determined in rain and dry fallout, airborne dust, service water, total diet, rice, milk, vegetables, sea fish, shellfish, and seaweeds. The results were shown in tables. (J.P.N.)

  1. Retinoblastoma Control With Primary Intra-arterial Chemotherapy: Outcomes Before and During the Intravitreal Chemotherapy Era.

    Science.gov (United States)

    Shields, Carol L; Alset, Adel E; Say, Emil Anthony T; Caywood, Emi; Jabbour, Pascal; Shields, Jerry A

    2016-09-01

    To compare outcomes of intra-arterial chemotherapy for retinoblastoma as primary therapy before (Era I) and during (Era II) the intravitreal chemotherapy era. In this retrospective interventional case series at a tertiary referral center, 66 eyes of 66 patients with untreated unilateral retinoblastoma were used. intraarterial chemotherapy into the ophthalmic artery under fluoroscopic guidance was performed using melphalan in every case, with additional topotecan as necessary. Intravitreal chemotherapy using melphalan and/or topotecan was employed as needed for active vitreous seeding. Globe salvage was measured based on the International Classification of Retinoblastoma (ICRB) during two eras. The two eras encompassed 2008 to 2012 (intraarterial chemotherapy alone, Era I) and 2012 to 2015 (intraarterial chemotherapy plus intravitreal chemotherapy, Era II). Over this period, there were 66 patients with unilateral untreated retinoblastoma treated with primary intra-arterial chemotherapy. A comparison of features (Era I vs Era II) revealed no significant difference in mean patient age (24 vs 24 months), ICRB groups, mean largest tumor diameter (19 vs 17 mm), mean largest tumor thickness (10 vs 10 mm), vitreous seed presence (56% vs 59%), subretinal seed presence (67% vs 62%), retinal detachment (70% vs 66%), or vitreous hemorrhage (0% vs 5%). There was no significant difference in mean number of intra-arterial chemotherapy cycles (3 vs 3.1) or intraarterial chemotherapy dosages. Following therapy, there was a significant difference (Era I vs Era II) in the need for enucleation overall (44% vs 15%, P = .012), especially for group E eyes (75% vs 27%, P = .039). Four of the eyes that initiated therapy in Era I later required intravitreal chemotherapy during Era II. The enucleation rate was 0% for groups B and C in both eras and non-significant for group D (23% vs 13%). There were no patients with stroke, seizure, limb ischemia, extraocular tumor extension, secondary

  2. Staging laparoscopy leads to rapid induction of chemotherapy for unresectable pancreatobiliary cancers.

    Science.gov (United States)

    Hashimoto, Daisuke; Chikamoto, Akira; Sakata, Kazuya; Nakagawa, Shigeki; Hayashi, Hiromitsu; Ohmuraya, Masaki; Hirota, Masahiko; Yoshida, Naoya; Beppu, Toru; Baba, Hideo

    2015-02-01

    Preoperatively evaluating the resectability of pancreatobiliary cancers is difficult. The aim of this study was to investigate the benefit of staging laparoscopy in unresectable pancreatobiliary cancers. Between 2010 and 2013, 25 patients with pancreatobiliary cancers underwent staging laparoscopy after conventional tumor staging; they were compared with 10 patients who had unresectable or metastatic tumors that were found during laparotomy. Staging laparoscopy did not show unresectable factors in 11 patients, and resections were performed in these patients. Unresectable factors were found in other 14 patients who underwent staging laparoscopy. In these patients, chemotherapy was started after median postoperative day 3 (range, 2-10 days). This period was significantly longer in patients who received unnecessary laparotomy; chemotherapy was started after median postoperative day 11 (range, 6-15 days). These results suggest that staging laparoscopy, while avoiding laparotomy with unsuccessful resection, can lead to rapid induction of chemotherapy for unresectable pancreatobiliary cancers. © 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd.

  3. Whistleblowing in Japan.

    Science.gov (United States)

    Davis, Anne J; Konishi, Emiko

    2007-03-01

    This article, written from research data, focuses on the possible meaning of the data rather than on detailed statistical reporting. It defines whistleblowing as an act of the international nursing ethical ideal of advocacy, and places it in the larger context of professional responsibility. The experiences, actions, and ethical positions of 24 Japanese nurses regarding whistleblowing or reporting a colleague for wrongdoing provide the data. Of these respondents, similar in age, educational level and clinical experience, 10 had previously reported another nurse and 12 had reported a physician for a wrongful act. These data raise questions about overt actions to expose a colleague in a culture that values group loyalty and saving face. Additional research is needed for an in-depth understanding of whistleblowing, patient advocacy and professional responsibility across cultures, especially those that value group loyalty, saving face and similar concepts to the Japanese Ishin Denshin, where the value is on implicit understanding requiring indirect communication. Usually, being direct and openly discussing sensitive topics is not valued in Japan because such behavior disrupts the most fundamental value, harmony (wa).

  4. Dysphagia Rehabilitation in Japan.

    Science.gov (United States)

    Inoue, Makoto

    2015-01-01

    In Japan, one of the most common causes of death in elderly people is aspiration pneumonia. Maintenance of oral hygiene and feeding functions are important elements, especially in patients with dysphagia caused by stroke, neurological diseases, and after operations on the head and neck cancer, as well as in the elderly to prevent aspiration pneumonia. It should also be noted that not only oral health care and physical therapy related to feeding functions but also dental treatment is included in the clinical management during interventions whenever needed. On the other hand, for the patients and/or elderly in need of assistance in maintaining a safe diet, it is recommended that a specialized team comprising physicians, dentists, and speech therapists in functional rehabilitation observes meal conditions of the subjects and evaluates such factors as meal contents, posture during meals, usage of dishes and cutlery, meal times, status of consciousness, perception, and motivation. First, I will present the clinical interventions to those patients, which include oral health care, dental treatment, physical therapy and meal assistance, as well as team approaches in those circumstances. In addition, clinical and basic research results will be introduced, which are expected to foster the understanding of physiology in chewing and swallowing. These results are also expected to develop the clinical technology to maintain or recover the feeding functions.

  5. Globalization in Japan

    DEFF Research Database (Denmark)

    Roesgaard, Marie Højlund

    2014-01-01

    of development and discourse on morality, values and identity. I propose seeing the contents of moral education as a reaction to the challenges of globalization, as a reaction to the risks experienced in modern globalized society and to the anxiety born out of the challenges, ‘real’ or ‘imagined,’ perceived......Abstract for Nichibunken Copenhagen Symposium August 2012 Globalization in Japan – the case of moral education. 日本とグローバル化 - 道徳教育の件 Marie H. Roesgaard, Department of Cross-Cultural and Regional Studies, University of Copenhagen. This paper attempts to trace the history of global influence...... on Japanese education by using moral education as a case. Moral education, known as shūshin before World War II, has been prominent in Japanese education since its formalization in Meiji times. From Meiji on shûshin underwent various changes, reflected in the textbooks of different periods. 1903...

  6. Fusion Studies in Japan

    Science.gov (United States)

    Ogawa, Yuichi

    2016-05-01

    A new strategic energy plan decided by the Japanese Cabinet in 2014 strongly supports the steady promotion of nuclear fusion development activities, including the ITER project and the Broader Approach activities from the long-term viewpoint. Atomic Energy Commission (AEC) in Japan formulated the Third Phase Basic Program so as to promote an experimental fusion reactor project. In 2005 AEC has reviewed this Program, and discussed on selection and concentration among many projects of fusion reactor development. In addition to the promotion of ITER project, advanced tokamak research by JT-60SA, helical plasma experiment by LHD, FIREX project in laser fusion research and fusion engineering by IFMIF were highly prioritized. Although the basic concept is quite different between tokamak, helical and laser fusion researches, there exist a lot of common features such as plasma physics on 3-D magnetic geometry, high power heat load on plasma facing component and so on. Therefore, a synergetic scenario on fusion reactor development among various plasma confinement concepts would be important.

  7. The photovoltaic energy in Japan

    International Nuclear Information System (INIS)

    Georgel, O.

    2005-07-01

    Today the Japan is the leader of the photovoltaic energy. The first reason of this success is an action of the government integrating subventions for the installation of photovoltaic systems and a support of the scientific research. To explain this success, the author presents the energy situation in Japan, details the national programs, the industrial sector (market, silicon needs, recycling, manufacturers, building industry) and presents the main actors. (A.L.B.)

  8. Understanding Japan's Capital Goods Exports

    OpenAIRE

    THORBECKE, Willem

    2015-01-01

    Japan is the leading supplier of sophisticated capital goods to East Asian countries. These goods embody advanced technologies and facilitate learning and productivity growth. Capital goods also represent 30%-40% of Japan's exports. This paper investigates the determinants of these exports. Results from dynamic ordinary least squares estimation indicate that exports depend on exchange rates, income in the importing countries, and downstream countries' exports to the rest of the world. Results...

  9. Japan Sports Arbitration Agency (JSAA

    Directory of Open Access Journals (Sweden)

    Ekaterina P. Rusakova

    2015-12-01

    Full Text Available In this article author analyzes the activities of Japan Sports Arbitration Agency. Author considers the goals, objectives and procedure for dealing with disputes relating to the use of performance-enhancing drugs by athletes. Author study the regulation of Japan Sports Arbitration Agency, to resolve disputes relating to the use of doping, as well as the procedure for application and acceptance of its agency, the choice of arbitrators, counterclaim, protection of evidence.

  10. The cogeneration market in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Watabe, Masaki [Cogeneration Research Society of Japan, Tokyo (Japan). Research Dept.

    1997-09-01

    Conventional power generation is only around 35% efficient at demand side in Japan. Cogeneration increases the overall energy efficiency up to 85%. Other merits of cogeneration are energy saving, improvement of the environment, greenhouse gas emission (CO{sub 2}) can be reduced. The energy conditions in Japan are overviewed and the trends for cogeneration - both commercial and industrial - are evaluated. Finally, statutory regulations regarding cogeneration systems are considered. (R.P.)

  11. Japan Sports Arbitration Agency (JSAA)

    OpenAIRE

    Ekaterina P. Rusakova

    2015-01-01

    In this article author analyzes the activities of Japan Sports Arbitration Agency. Author considers the goals, objectives and procedure for dealing with disputes relating to the use of performance-enhancing drugs by athletes. Author study the regulation of Japan Sports Arbitration Agency, to resolve disputes relating to the use of doping, as well as the procedure for application and acceptance of its agency, the choice of arbitrators, counterclaim, protection of evidence.

  12. Japan's approach to monetary policy

    OpenAIRE

    Giovanni P. Olivei

    2002-01-01

    The goal of monetary policy as conducted by the Bank of Japan is to contribute to the sound development of the national economy through the pursuit of price stability. The objective of price stability, however, is not precisely defined as it has been for other central banks. Following the implementation of the new Bank of Japan Law in 1998, the monetary policy framework is characterized by central bank independence, the primacy of the price stability objective, instrument independence, and po...

  13. Chemotherapy safety in clinical veterinary oncology.

    Science.gov (United States)

    Klahn, Shawna

    2014-09-01

    Exposure to chemotherapy is a health hazard for all personnel in facilities that store, prepare, or administer antineoplastic agents. Contamination levels have been measured as much as 15 times higher in the veterinary medicine sector than in human facilities. Recent publications in human and veterinary medicine indicate that exposure extends beyond the clinic walls to affect the patient's home and family. This article provides an update on the advances in chemotherapy safety, the current issues, and the impact on cancer management in veterinary medicine. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Combined, sequential intravenous and intra-arterial chemotherapy (bridge chemotherapy for young infants with retinoblastoma.

    Directory of Open Access Journals (Sweden)

    Y Pierre Gobin

    Full Text Available BACKGROUND: Intra-arterial (i.a. chemotherapy has more risks of procedural complications in neonates and young infants. For these reasons, we have developed a strategy of bridge intravenous single agent chemotherapy to postpone i.a. chemotherapy in these children PROCEDURE: Neonates and young infants with retinoblastoma who required chemotherapy were treated with systemic carboplatin chemotherapy (18.7 mg/kg i.v. every 3-4 weeks until they reached the age of 3 months and a weight of 6 Kg. If necessary, i.a. chemotherapy was subsequently performed at 4 weeks intervals. Efficacy was judged by tumor regression on ophthalmological examination. Retinal toxicity was judged by electroretinography. RESULTS: Eleven children (19 eyes were treated. All patients are alive and no patient has developed metastatic disease or second malignancies (mean follow-up 27 months, range 9-46 months. Intravenous carboplatin (median 2 cycles, range 1-5 combined with cryotherapy and laser was given to all children. This was effective for five eyes, which did not require i.a. chemotherapy. I.a. chemotherapy was administered to 14 eyes (median 3.5 cycles per eye, range 1 to 6. No radiation therapy was required. The Kaplan Meier estimate of ocular radiation-free survival was 94.7% at one year (95% confidence interval 68.1-99.2%. One eye was enucleated due to tumor progression. ERG showed no deterioration of retinal function. CONCLUSION: Bridge i.v.-i.a. chemotherapy was feasible and safe, and is a promising strategy to treat retinoblastoma in neonates and young infants.

  15. Retinoblastoma: Achieving new standards with methods of chemotherapy

    Directory of Open Access Journals (Sweden)

    Swathi Kaliki

    2015-01-01

    Full Text Available The management of retinoblastoma (RB has dramatically changed over the past two decades from previous radiotherapy methods to current chemotherapy strategies. RB is a remarkably chemotherapy-sensitive tumor. Chemotherapy is currently used as a first-line approach for children with this malignancy and can be delivered by intravenous, intra-arterial, periocular, and intravitreal routes. The choice of route for chemotherapy administration depends upon the tumor laterality and tumor staging. Intravenous chemotherapy (IVC is used most often in bilateral cases, orbital RB, and as an adjuvant treatment in high-risk RB. Intra-arterial chemotherapy (IAC is used in cases with group C or D RB and selected cases of group E tumor. Periocular chemotherapy is used as an adjunct treatment in eyes with group D and E RB and those with persistent/recurrent vitreous seeds. Intravitreal chemotherapy is reserved for eyes with persistent/recurrent vitreous seeds. In this review, we describe the various forms of chemotherapy used in the management of RB. A database search was performed on PubMed, using the terms "RB," and "treatment," "chemotherapy," "systemic chemotherapy," "IVC," "IAC," "periocular chemotherapy," or "intravitreal chemotherapy." Relevant English language articles were extracted, reviewed, and referenced appropriately.

  16. Retinoblastoma: Achieving new standards with methods of chemotherapy

    Science.gov (United States)

    Kaliki, Swathi; Shields, Carol L

    2015-01-01

    The management of retinoblastoma (RB) has dramatically changed over the past two decades from previous radiotherapy methods to current chemotherapy strategies. RB is a remarkably chemotherapy-sensitive tumor. Chemotherapy is currently used as a first-line approach for children with this malignancy and can be delivered by intravenous, intra-arterial, periocular, and intravitreal routes. The choice of route for chemotherapy administration depends upon the tumor laterality and tumor staging. Intravenous chemotherapy (IVC) is used most often in bilateral cases, orbital RB, and as an adjuvant treatment in high-risk RB. Intra-arterial chemotherapy (IAC) is used in cases with group C or D RB and selected cases of group E tumor. Periocular chemotherapy is used as an adjunct treatment in eyes with group D and E RB and those with persistent/recurrent vitreous seeds. Intravitreal chemotherapy is reserved for eyes with persistent/recurrent vitreous seeds. In this review, we describe the various forms of chemotherapy used in the management of RB. A database search was performed on PubMed, using the terms “RB,” and “treatment,” “chemotherapy,” “systemic chemotherapy,” “IVC,” “IAC,” “periocular chemotherapy,” or “intravitreal chemotherapy.” Relevant English language articles were extracted, reviewed, and referenced appropriately. PMID:25827539

  17. Nuclear power in Japan

    International Nuclear Information System (INIS)

    Kishida, J.

    1990-01-01

    The Japanese movement against nuclear energy reached a climax in its upsurge in 1988 two years after the Chernobyl accident. At the outset of that year, this trend was triggered by the government acknowledgement that the Tokyo market was open to foods contaminated by the fallout from Chernobyl. Anti-nuclear activists played an agitating role and many housewives were persuaded to join them. Among many public opinion surveys conducted at that time by newspapers and broadcasting networks, I would like to give you some figures of results from the poll carried out by NHK: Sixty percent of respondents said that nuclear power 'should be promoted', either 'vigorously' 7 or 'carefully' 53%). Sixty-six percent doubted the 'safety of nuclear power', describing it as either 'very dangerous' 20%) or 'rather dangerous' (46%). Only 27% said it was 'safe'. In other words, those who acknowledged the need for nuclear power were almost equal in number with those who found it dangerous. What should these figures be taken to mean? I would take note of the fact that nearly two-thirds of valid responses were in favor of nuclear power even at the time when public opinion reacted most strongly to the impact of the Chernobyl accident. This apparently indicates that the majority of the Japanese people are of the opinion that they would 'promote nuclear power though it is dangerous' or that they would 'promote it, but with the understanding that it is dangerous'. But the anti-nuclear movement is continuing. It remains a headache for both the government and the electric utilities. But we can regard the anti-nuclear movement in Japan as not so serious as that faced by other industrial nations

  18. Imported malaria in pregnant women experienced in Japan.

    Science.gov (United States)

    Kimura, Mikio; Koga, Michiko; Hasegawa, Chihiro; Mutoh, Yoshikazu; Kato, Yasuyuki; Maruyama, Haruhiko

    2017-08-01

    With ever-growing global exchanges, the number of travelers, including pregnant women, to the tropics is increasing, which poses a risk of contracting malaria. Although there are several reports on imported malaria in pregnancy from Western countries, those focusing on cases experienced in Japan are very limited. We searched for cases of malaria in pregnancy in the treatment records submitted to the Research Group on Chemotherapy of Tropical Diseases, Japan, during the period 1993-2016. Literature searches were also conducted using an American and a Japanese search system. Ten cases of malaria in pregnant women were identified, including four cases with Plasmodium falciparum. Of eight evaluable cases, only one practiced malaria chemoprophylaxis. Among the nine evaluable cases, eight resulted in uneventful delivery and one P. falciparum case developed severe hepatic disturbance, disseminated intravascular coagulation, and intrauterine fetal death. After the initial attack, none of the Plasmodium vivax/Plasmodium ovale cases practiced chloroquine prophylaxis until delivery. One P. ovale case received a lower dose regimen of chloroquine as acute-stage therapy. This study demonstrated additional cases of imported malaria in pregnant women to the literature and highlighted various epidemiological, demographic, and clinical characteristics. Some of the clinical issues raised need to be investigated. Due to the paucity of the cases worldwide, sharing information among various countries is indispensable, and international guidelines which are now increasingly recommending the use of artemisinins in pregnant women should be referred. Copyright © 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  19. Management of chemotherapy-induced nausea and vomiting.

    LENUS (Irish Health Repository)

    Zubairi, Ishtiaq H

    2006-08-01

    Chemotherapy-induced nausea and vomiting are symptoms that cause major concern to oncology patients. This article explores the types of nausea and vomiting in the context of chemotherapy, and discusses their pathogenesis and management.

  20. Chemotherapy Side Effects: A Cause of Heart Disease?

    Science.gov (United States)

    ... A cause of heart disease? Can chemotherapy side effects increase the risk of heart disease? Answers from Timothy J. Moynihan, M.D. Chemotherapy side effects may increase the risk of heart disease, including ...

  1. Metallic taste in cancer patients treated with chemotherapy

    NARCIS (Netherlands)

    Ijpma, I.; Renken, R. J.; ter Horst, G. J.; Reyners, A. K. L.

    Background: Metallic taste is a taste alteration frequently reported by cancer patients treated with chemotherapy. Attention to this side effect of chemotherapy is limited. This review addresses the definition, assessment methods, prevalence, duration, etiology, and management strategies of metallic

  2. Managing Chemotherapy Side Effects: Sexual and Fertility Changes in Women

    Science.gov (United States)

    N ational C ancer I nstitute Managing Chemotherapy Side Effects Sexual and Fertility Changes in Women “Talk with your doctor before you start treatment. Ask how chemotherapy could affect your ability to have children. ” Ask what ...

  3. Ultrasound sensitizes chemotherapy in chemoresistant ovarian ...

    African Journals Online (AJOL)

    Administrator

    2011-09-26

    Sep 26, 2011 ... Chemotherapy resistance is still a great challenge to the management of ovarian cancers. Using ... gynecological malignancies. Of those factors .... it is difficult to develop a chemical sensitizer. Either adriamycin- or cisplatin-resistance was overcome by insonation in this. GAPDH. MDR. Control Ultrasound ...

  4. Managing Chemotherapy Side Effects: Urination Changes

    Science.gov (United States)

    ... is a different color, such as orange, red, green, or dark yellow l Urine that has a strong smell l Trouble urinating It is common for your urine to change color or smell different during chemotherapy. Talk with your doctor or nurse to learn ...

  5. Experiences of patients undergoing chemotherapy - a qualitative ...

    African Journals Online (AJOL)

    Background: Cancer is a global public health challenge and how patients in countries with poor healthcare infrastructure expe- ... Purpose: The objective of this study was to describe adult Ugandan cancer patients' experiences of undergoing chemotherapy .... and breast), as well as treatment (limited surgery, radio-.

  6. New therapies for antiemetic prophylaxis for chemotherapy.

    Science.gov (United States)

    Davis, Mellar P

    2016-01-01

    A number of new advances have occurred over the past 2 years in the management of chemotherapy-related nausea and vomiting (CINV). A new neurokinin-1 receptor antagonist (NK1RA), netupitant, has been combined with palonosetron in a single oral tablet for treating the effects of moderately emetogenic chemotherapy (MEC) and highly emetogenic chemotherapy (HEC). Rolapitant, another NK1RA, unlike aprepitant, has a long half-life and does not block CYP-3A4 and therefore has fewer drug interactions. Olanzapine reduces nausea more effectively than aprepitant in patients who are receiving HEC and is a better rescue antiemetic than is metoclopramide. Ginger lacks efficacy as an antiemetic agent for CINV. Although there was some evidence in a pilot study of gabapentin as an antiemetic, it was no better in reducing CINV than was placebo. Compliance to guidelines in multiple settings ranges from 50%-60% but is improved by computerized order entry of antiemetics and recommendations displayed with chemotherapy. ©2016 Frontline Medical Communications.

  7. Pathological response for neoadjuvant chemotherapy in locally ...

    African Journals Online (AJOL)

    Background: Breast cancer is the leading cancer in Sudanese females. Objectives: This study was done to evaluate the clinical response to neoadjuvant chemotherapy for patients treated at National Cancer Institute (NCI) and to compare it with the published literature. Methods: This is a retrospective study conducted in ...

  8. Aspects of enteral nutrition in cancer chemotherapy

    NARCIS (Netherlands)

    Smit, Jitske Martha

    1985-01-01

    This thesis deals with several aspects of the influences of intensive cancer chemotherapy on the nutritional status, the metabolism, and the gastrointestinal tract of the host and describes whether these results can be influenced by enteral hyperalimentation, We studied these aspects in patients

  9. Haemorheological changes in cancer patients on chemotherapy

    International Nuclear Information System (INIS)

    Omoti, C.E.; Osime, E.

    2007-01-01

    To assess the rheological changes in haematological and non-haematological cancer patients pre and post chemotherapy. It is a prospective study of 50 patients comprising 16(32%) haematological and 34(68%) non-haematological cancers of various types from March to December 2005 at University of Benin Teaching Hospital, Nigeria. Rheologic parameters estimated by the various specific diagnostic methods were determined in cancer patient's pre and post chemotherapy. The rheological tests estimated were relative plasma viscosity (RPV) measured by means of a capillary viscometer, whole blood viscosity (WBV), erythrocyte sedimentation rate (ESR) and plasma fibrinogen concentration (PFC) estimated by the Ingram's Clot weight method. The RPV in pre chemotherapy (p=0.006) and WBV in post chemotherapy (p=0.0231) patients measured revealed a significant difference when compared to controls. The fibrinogen concentration (P<0.0001) and ESR values (P<0.0001) were significantly increased in cancer patients when compared to controls. We conclude that total reduction of hyperviscosity and hyperfibrinogenaemia may contribute to effective treatment strategies in cancer patients. (author)

  10. Antimicrobial chemotherapy and Sustainable Development: The ...

    African Journals Online (AJOL)

    Antimicrobial chemotherapy is a highly valued medical science which has shaped modern humanity in a phenomenal fashion. Within the past half century, a wide variety of antimicrobial substances have been discovered, designed and synthesized; literally hundreds of drugs have been successfully used in some fashion ...

  11. Default from neoadjuvant chemotherapy in premenopausal female ...

    African Journals Online (AJOL)

    Seventeen (38.6%) patients dropped out of treatment, before, during or after completing NAC. Ten of these defaulted due to inadequate funds to procure chemotherapy, three patients because they insisted on immediate mastectomy, and four of these patients refused surgery when they achieved complete clinical response, ...

  12. Medication safety in the ambulatory chemotherapy setting.

    Science.gov (United States)

    Gandhi, Tejal K; Bartel, Sylvia B; Shulman, Lawrence N; Verrier, Deborah; Burdick, Elisabeth; Cleary, Angela; Rothschild, Jeffrey M; Leape, Lucian L; Bates, David W

    2005-12-01

    Little is known concerning the safety of the outpatient chemotherapy process. In the current study, the authors sought to identify medication error and potential adverse drug event (ADE) rates in the outpatient chemotherapy setting. A prospective cohort study of two adult and one pediatric outpatient chemotherapy infusion units at one cancer institute was performed, involving the review of orders for patients receiving medication and/or chemotherapy and chart reviews. The adult infusion units used a computerized order entry writing system, whereas the pediatric infusion unit used handwritten orders. Data were collected between March and December 2000. The authors reviewed 10,112 medication orders (8008 adult unit orders and 2104 pediatric unit orders) from 1606 patients (1380 adults and 226 pediatric patients). The medication error rate was 3% (306 of 10,112 orders). Of these errors, 82% occurring in adults (203 of 249 orders) had the potential for harm and were potential ADEs, compared with 60% of orders occurring in pediatric patients (34 of 57 orders). Among these, approximately one-third were potentially serious. Pharmacists and nurses intercepted 45% of potential ADEs before they reached the patient. Several changes were implemented in the adult and pediatric settings as a result of these findings. In the current study, the authors found an ambulatory medication error rate of 3%, including 2% of orders with the potential to cause harm. Although these rates are relatively low, there is clearly the potential for serious patient harm. The current study identified strategies for prevention.

  13. Comparison of chemotherapy and hematopoietic stem cell ...

    African Journals Online (AJOL)

    2013-02-19

    Feb 19, 2013 ... protocol was implemented that consisted of restoration of all active carious lesions, treatment of periodontal infections, ... Conclusions: DMFT scores were found to increase after chemotherapy and HSCT, suggesting that the risk of infection ... immune disorders, and myelodysplastic syndromes.[1‑5].

  14. Biochemistry and Chemotherapy of Malaria and Leishmaniasis

    Science.gov (United States)

    1993-12-06

    Agents and Chemotherapy. 12:1763-68. (13) Focke M. Feld A. Lichtenthaler K. 1989. Allicin, a Naturally Occurring Antibiotic from Garlic , Specifically...ethanol plant extracts including; nutmeg (Myristicaceae sp.), ginger (Zingiber officinale), goldenseal root (Hydrastis canadensis), garlic (Allium...sativum), elephant garlic (Allium scorodoprasum), onion (Allium cepa), and licorice (Glycyrrhiza glabra). Cells of Leish- mania mexicana 227 and

  15. Impact of the economic crisis on human mobility in Japan : a preliminary note L’impact de la crise économique sur la mobilité humaine au Japon : note préliminaire

    Directory of Open Access Journals (Sweden)

    Yoshitaka Ishikawa

    2012-12-01

    Full Text Available The central aim of this paper is to explore the impact of the global economic crisis on different categories of human mobility, including migration and tourism, in Japan. The major findings can be summarized as follows. First, since the fall of 2008 the crisis has had a far-reaching influence on Japan, for both the ethnic majority and minorities. Second, the intensity of the negative impact has varied by metropolitan areas and nationalities. Japanese nationals in the Tokyo metropolitan area and migrant workers (particularly Brazilians in the Nagoya metropolitan area and central Japan manufacturing prefectures are the most affected population groups. Finally, support programs by the Japanese government were problematic, and, in particular, the program that provided incentives for migrant workers to voluntarily return to their home countries was introduced too late. However, it is too early to clearly elucidate the full impact of the crisis, since the latest available data confirm that the current situation remains in a state of crisis.L’article vise à explorer l’impact de la crise économique mondiale sur différentes catégories de mobilité humaine au Japon, y compris les migrations et le tourisme. Les résultats principaux de l’étude peuvent se résumer comme suit. En premier lieu, depuis l’automne 2008, la crise a eu une influence non négligeable sur le pays, à la fois pour la majorité et pour les minorités ethniques. Ensuite, l’intensité de l’impact négatif a varié selon les zones métropolitaines et les nationalités. Les nationaux de la zone métropolitaine de Tokyo, ainsi que les travailleurs migrants (surtout des Brésiliens de la zone de Nagoya et des préfectures manufacturières du centre sont les groupes les plus touchés. Enfin, les programmes d’aide mis en place par le gouvernement japonais se sont révélés problématiques, en particulier celui qui offrait des incitations au retour volontaire vers les pays

  16. Radar Image, Hokkaido, Japan

    Science.gov (United States)

    2000-01-01

    The southeast part of the island of Hokkaido, Japan, is an area dominated by volcanoes and volcanic caldera. The active Usu Volcano is at the lower right edge of the circular Lake Toya-Ko and near the center of the image. The prominent cone above and to the left of the lake is Yotei Volcano with its summit crater. The city of Sapporo lies at the base of the mountains at the top of the image and the town of Yoichi -- the hometown of SRTM astronaut Mamoru Mohri -- is at the upper left edge. The bay of Uchiura-Wan takes up the lower center of the image. In this image, color represents elevation, from blue at the lowest elevations to white at the highest. The radar image has been overlaid to provide more details of the terrain. Due to a processing problem, an island in the center of this crater lake is missing and will be properly placed when further SRTM swaths are processed. The horizontal banding in this image is a processing artifact that will be removed when the navigation information collected by SRTM is fully calibrated. This image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between the National Aeronautics and Space Administration (NASA), the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense (DoD), and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Earth Science Enterprise, Washington, DC. Size: 100 by 150 kilometers (62

  17. [Scleroderma-like skin sclerosis induced by docetaxel chemotherapy for hormone refractory prostate cancer: a case report].

    Science.gov (United States)

    Maehana, Takeshi; Mizuno, Takahiro; Muto, Masatoshi; Nishiyama, Naotaka; Yanase, Masahiro

    2010-09-01

    We report the first case of scleroderma-like skin sclerosis induced by docetaxel chemotherapy for prostate cancer in Japan. A 67-year-old man underwent radical prostatectomy for cT3aN0M0 prostate cancer in 2003. Thereafter PSA recurrence developed and antiandrogen deprivation therapy was used. However, we diagnosed this case as hormone refractory prostate cancer and began docetaxel chemotherapy in October 2008. There were no nonhematological adverse events through two courses of treatment. He presented to dermatology due to pain and swelling of both upper arms on the second day of the third course. However, when treated with a cooling method, swelling of the upper arms became worse and CPK rose to 1,921 IU/I on the eighth day. We administered a steroid ointment and an antibiotic due to suspicion of thrombophlebitis. Nevertheless, CPK rose to 2,791 IU/I and a skin biopsy was done. In consequence, scleroderma-like skin sclerosis induced by docetaxel chemotherapy was diagnosed. Swelling appeared in both lower limbs and the pain got worse on the 17th day. Therefore docetaxel chemotherapy was discontinued and prednisolone was increased to 30 mg/day, in addition to beginning codeine use for the pain. Thereafter, the painful sclerosis was ameliorated.

  18. The effect of hyperthermia in the preoperative combined treatment of radiation, hyperthermia and chemotherapy for rectal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Konishi, Fumio; Furuta, Kazuhiro; Saito, Yukio; Kataoka, Takashi; Kashiwagi, Hiroshi; Okada, Masaki; Kanazawa, Kyotaro; Sugahara, Tadashi; Shinohara, Naohiro (Jichi Medical School, Minamikawachi, Tochigi (Japan))

    1994-03-01

    To investigate the effectiveness of hyperthermia in the preoperative combined treatment of radiation, chemotherapy and hyperthermia for rectal carcinoma, two groups were compared. Group A consisted of 18 patients in whom hyperthermia, radiation and chemotherapy were performed. Group B consisted of 18 patients in whom only chemotherapy and radiation were performed. The total dose of radiation in both of the two groups was 40.5 Gy, and a radiation field covering the whole pelvis was used. Hyperthermia was performed using 8 MHz radiofrequency waves (Thermotron RF8, Yamamoto Vinyter, Japan), and tumors were heated at about 42 degrees C for 50 minutes. Hyperthermia was repeated five times during the preoperative treatment. Chemotherapy was performed by giving 5-fluorouracil suppositories to a total dose of 3400 mg. Mean tumor reduction rates on barium enema were 31.8% in group A and 18.2% in group B. The difference was statistically significant. The result of the histological assessment of tumor necrosis showed that there was a significantly higher degree of necrosis in group A than in group B. These results showed that the addition of hyperthermia enhanced tumor necrosis. It was concluded that the addition of hyperthermia would be an effective preoperative treatment of rectal carcinoma. (author).

  19. The effect of hyperthermia in the preoperative combined treatment of radiation, hyperthermia and chemotherapy for rectal carcinoma

    International Nuclear Information System (INIS)

    Konishi, Fumio; Furuta, Kazuhiro; Saito, Yukio; Kataoka, Takashi; Kashiwagi, Hiroshi; Okada, Masaki; Kanazawa, Kyotaro; Sugahara, Tadashi; Shinohara, Naohiro

    1994-01-01

    To investigate the effectiveness of hyperthermia in the preoperative combined treatment of radiation, chemotherapy and hyperthermia for rectal carcinoma, two groups were compared. Group A consisted of 18 patients in whom hyperthermia, radiation and chemotherapy were performed. Group B consisted of 18 patients in whom only chemotherapy and radiation were performed. The total dose of radiation in both of the two groups was 40.5 Gy, and a radiation field covering the whole pelvis was used. Hyperthermia was performed using 8 MHz radiofrequency waves (Thermotron RF8, Yamamoto Vinyter, Japan), and tumors were heated at about 42 degrees C for 50 minutes. Hyperthermia was repeated five times during the preoperative treatment. Chemotherapy was performed by giving 5-fluorouracil suppositories to a total dose of 3400 mg. Mean tumor reduction rates on barium enema were 31.8% in group A and 18.2% in group B. The difference was statistically significant. The result of the histological assessment of tumor necrosis showed that there was a significantly higher degree of necrosis in group A than in group B. These results showed that the addition of hyperthermia enhanced tumor necrosis. It was concluded that the addition of hyperthermia would be an effective preoperative treatment of rectal carcinoma. (author)

  20. Urgent Safety Measures in Japan after Great East Japan Earthquake

    International Nuclear Information System (INIS)

    Taniura, W.; Otani, H.

    2012-01-01

    Due to tsunami triggered by the Great East Japan Earthquake on March 11, 2011, the operating and refueling reactor facilities at Fukushima Dai-ichi and Dai-ni Nuclear Power Plants of Tokyo Electric Power Co. caused a nuclear hazard. Japanese electric power companies voluntarily began to compile various urgent measures against tsunami within the week the hazard was caused. As for the urgent safety measures of each licensee, it is clarified that effective measures have been appropriately implemented as a result of the inspection of the national government, the verification based on the guideline of the Japan Society of Maintenology and the stress test. (author)

  1. The effect of chemotherapy on rat brain PET: preliminary study

    International Nuclear Information System (INIS)

    Kim, Jin Su; Kim, Il Han; Yu, A Ram; Park, Ji Ae; Woo, Sang Keun; Kim, Jong Guk; Cheon, Gi Jeong; Kim, Byeong Il; Choi, Chang Woon; Lim, Sang Moo; Kim, Hee Joung; Kim, Kyeong Min

    2010-01-01

    Chemotherapy was widely used for the therapy of cancer patients. When chemotherapy was performed, transient cognitive memory problem was occurred. This cognitive problem in brain was called as chemobrain. In this study, we have developed rat model for chemobrain. Cerebral glucose metabolism after chemotherapy was assessed using animal PET and voxel based statistical analysis method

  2. Adjuvant chemotherapy for stage I non-seminomatous testicular ...

    African Journals Online (AJOL)

    The chemotherapy regimen consisted of 2 cycles of cisplatin, etoposide and bleomycin. Each cycle of chemotherapy lasted 3 days. There have been no relapses at a median follow-up of 31 months (range 12 - 53 months). Acute and late toxicity have been modest. We have found adjuvant chemotherapy to be effective after ...

  3. Chemotherapy and Hair Loss: What to Expect during Treatment

    Science.gov (United States)

    ... Sometimes your eyelash, eyebrow, armpit, pubic and other body hair also falls out. Some chemotherapy drugs are more ... dose of chemotherapy as the rest of your body. People undergoing scalp hypothermia ... a drug approved for hair loss — to your scalp before and during chemotherapy ...

  4. Weight change during chemotherapy in breast cancer patients

    NARCIS (Netherlands)

    Berg, M.M.G.A.; Winkels, R.M.; Kruif, J.Th.C.M.; Laarhoven, H.W.M.; Visser, M.; Vries, de Jeanne; Vries, Y.C.; Kampman, E.

    2017-01-01

    Background: Weight gain during chemotherapy in women with breast cancer is commonly reported. However, there are important differences between studies that examined weight change during chemotherapy; e.g. type of chemotherapy, menopausal status, time between body weight measurements and sample

  5. A Simple Method to Optimize the Effectiveness of Chemotherapy: Modulation of Glucose Intake During Chemotherapy.

    Science.gov (United States)

    Icard, Philippe; Teboul, Bernard; El Baze, Philip

    2017-11-01

    Cancer cells consume high amounts of glucose to produce ATP and molecules entering biosynthesis. Numerous experimental studies have demonstrated that glucose deprivation and/or glycolysis inhibition arrest cancer cell growth and may increase the efficiency of cytotoxic drugs. In contrast, increasing glycolysis in tumor-infiltrating lymphocytes (TILs) activates these cells that destroy cancer cells. We propose to increase the efficiency of chemotherapy by modulating glucose intake during the course of chemotherapy. Glucose and caloric intake should be drastically reduced the day before and during chemotherapy administration to deprive cancer cells of ATP and molecules required to repair cytotoxic lesions. Few hours after chemotherapy, glucose and caloric intake should be drastically increased for few days to promote the activation of TILs that reinforce the destruction of cancer cells. This strategy could improve the results of chemotherapy by first enhancing cytotoxic stress against tumor cells and then promoting activation of the anti-cancer immune response. The modulation of glucose intake during chemotherapy should be tested clinically. The proposed scheme is simple, surely easier to follow than a strict chronic diet, and should avoid weight loss. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  6. Positioning Indian Emigration to Japan

    DEFF Research Database (Denmark)

    D'Costa, Anthony

    2013-01-01

    The purpose of this paper is to show how the Indian IT industry could position itself in the Japanese market. But in order to accomplish this, it is necessary to identify the key challenges and opportunities the Indian IT industry faces in the Japanese market. The opportunities for India, as well...... as other IT-strong developing countries, are to supply technical talent, whose availability in Japan is constrained by the secular demographic crisis and changing educational and occupational preferences. The challenges for India are the institutional barriers, in particular, Japanese business practices...... that act as significant barriers to the entry of foreign skilled professionals. The paper brings out the source and pattern of foreign professionals and students in Japan as a proxy for talent. Though India’s presence in Japan is currently limited, its share of technical professionals to the total number...

  7. Effect of interleukin-2 + pirarubicin infusion chemotherapy combined with systemic chemotherapy on the malignant biological behavior of advanced bladder cancer

    Directory of Open Access Journals (Sweden)

    Hong-Mei Zhang

    2017-09-01

    Full Text Available Objective: To study the effect of interleukin-2 + pirarubicin infusion chemotherapy combined with systemic chemotherapy on the malignant biological behavior of advanced bladder cancer. Methods: Patients with advanced bladder cancer who were treated in Tongcheng People’s Hospital between April 2015 and July 2016 were selected as the research subjects and randomly divided into group A who received interleukin-2 + pirarubicin infusion chemotherapy combined with systemic chemotherapy and the group B who received pirarubicin infusion chemotherapy combined with systemic chemotherapy. The contents of tumor markers and cytokines and the expression of apoptosis molecules in the urine were detected before and after chemotherapy. Results: 8 weeks after chemotherapy, BLCA-1, BLCA-4, CYFRA21-1, TGF-β1, VEGF, EGF, HGF and IGF-2 contents in urine of both groups of patients were significantly lower than those before treatment, Fas, Bad, PTEN and Beclin-1 mRNA expression in urine were significantly higher than those before treatment and BLCA-1, BLCA-4, CYFRA21-1, TGF-β1, VEGF, EGF, HGF and IGF-2 contents in urine of group A were significantly lower than those of group B, Fas, Bad, PTEN and Beclin-1 mRNA expression in urine were significantly higher than those of group B. Conclusion: Interleukin-2 + pirarubicin infusion chemotherapy combined with systemic chemotherapy can be more effective than pirarubicin infusion chemotherapy combined with systemic chemotherapy in inhibiting the malignant biological behavior of advanced bladder cancer.

  8. Japan og Singapore i Arktis

    DEFF Research Database (Denmark)

    Tonami, Aki; Watters, Stewart

    2013-01-01

    are interested in the Arctic. Looking at the Arctic engagement of Japan and Singapore, this paper finds that their interest in the Polar Regions is not necessarily a new phenomenon and that Arctic policy, as with the development of other foreign policy objectives, is a complex mix of national, bureaucratic...... and group interests. For Greenlandic and Danish policymakers, it may be useful to understand the genesis of Japan and Singapore’s Arctic policies and that their interest is complex and multi-faceted....

  9. Recycling of plastics in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Masaki, K. [Clean Japan Center, Tokyo (Japan). PET Bottle Recycling Project Dept.

    1998-10-01

    The Clean Japan Center is an NGO concerned with recycling. This article presents an overview of methods for recyling products made of various types of plastic. A number of such methods are in use or being studied. Emphasis is given to the state of plastics recycling in Japan. The uses of waste plastics as materials in other industrials is outlined - these include waste plastics as a reducer in blast furnaces, replacing coke and pulverized coal; waste plastics as a source of heat in cement kilns as an alternative to pulverized coal; and waste plastics being incinerated to generate power. 3 figs.

  10. The educational system in Japan

    Science.gov (United States)

    Spearman, M. L.

    1986-01-01

    The rapid economic growth of Japan since World War II has resulted in Japan becoming a reference point for developing nations and the West. This remarkable growth results from a combination of factors, one of which has been unyielding attention to education in order to cultivate the human talent necessary to provide the productivity for economic growth. The Japanese education system emphasizes quality of instruction and rewards hard work. Some of the principles of the system are outlined together with a summary of the content of the curriculum, the quantity and quality of instruction, and the influence of culture and environment.

  11. Local Government System in Japan

    Directory of Open Access Journals (Sweden)

    Vladimir V. Redko

    2016-12-01

    Full Text Available The article is devoted to the issues of the activities of the local government of Japan. Particular attention is drawn to the legal framework and the material basis for the functioning of local self-government bodies. The system of local self-government is considered as a special form of self-government with a specific functional and meaning; system of municipal management and delegation of authority, as well as features of interaction between civil and imperious levels. The allocation of the city with a special status, as well as the financial structure of the local government of Japan, is considered in detail.

  12. [[Fertility in Japan: 1990

    Science.gov (United States)

    Hirosima, K; Yamamoto, C

    1992-04-01

    Japan's number of births for 1990 was 1,229,044, which was 25,000 less than 1989. The decrease, however, was smaller than the decrease which occurred between 1988 and 1989. Table 1 shows total number of births of Japanese and number of births of non-Japanese. Since 1987 number of births of non-Japanese has been slightly over 7000 every year, constituting 0.6% of total births. Table 2 shows total number of Japanese births, number of those with Japanese parents, number of those with non-Japanese mothers and number of those with non-Japanese fathers. The number of those with at least one non-Japanese parent was slightly over 1% in 1990. Table 3 shows in thousands, (1) number of births, (2) married female population ages 20-34, (3) female population ages 20-34, (4) total population. The second wave of baby boomers is now beginning to get married and reproduce, which has resulted in a slight increase in child births among women below 24. Child births among those below age 23 were 94,871 in 1988, 95,102 in 1989, and 98,632 in 1990. The same data for those below age 24 was 143,495 in 1989 and 147,037 in 1990. 1990's number of births was 63.1% of 1970's, which showed the onset of a second baby boom. This is due to a lower rate of currently married women, lower number of women ages 20 to 34, and lower fertility rate among currently married women. Total fertility rate dropped from 2.18 to 1.47 for males, from 2.13 to 1.53 for females, from 2.16 to 1.50 for the total. Ever-married total fertility rate went from 2.08 to 1.95 for males, from 2.13 to 1.98 for females. The reason why TFR was so low in 1980's was that total first marriage rate was as low as 70%. Between 1989 and 1990 age-specific fertility rates for males 34 years and above and for females 31 years and above, as well as that for both males and females 22 years and under, increased. 31-year-old males and 28-year-old females showed the highest age-specific fertility rate in 1990. Between 1975 and 1990 average age

  13. DOD Milk Plants in the Pacific Japan

    National Research Council Canada - National Science Library

    1996-01-01

    .... Army Kanagawa milk plant in Japan. Since 1947, the Army has maintained a (Government-owned, contractor-operated milk plant in Yokohama, Japan, to provide milk and other dairy products to DoD personnel and their families...

  14. 75 FR 57980 - Polychloroprene Rubber From Japan

    Science.gov (United States)

    2010-09-23

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Polychloroprene Rubber From Japan AGENCY: United States International Trade Commission. ACTION... whether revocation of the antidumping duty finding on polychloroprene rubber from Japan would be likely to...

  15. BioBank Japan project: Epidemiological study

    OpenAIRE

    Kubo, Michiaki

    2017-01-01

    Highlights ? For precision medicine, genetic, clinical and environmental information is crucial. ? Biobank Japan project constructed a clinical database of 200,000 patients. ? This supplement reported the epidemiological studies in the Biobank Japan.

  16. Diffuse CO_{2} and ^{222}Rn degassing monitoring of Ontake volcano, Japan

    Science.gov (United States)

    Alonso, Mar; Sagiya, Takeshi; Meneses-Gutiérrez, Ángela; Padrón, Eleazar; Hernández, Pedro A.; Pérez, Nemesio M.; Melián, Gladys; Padilla, Germán D.

    2017-04-01

    Mt. Ontake (3067 m.a.s.l.) is a stratovolcano located in central Honsu and around 100 Km northeast of Nagoya, Japan, with the last eruption occurring on September 27, 2014, killing 57 people, and creating a 7-10 km high ash plume (Kagoshima et. al., 2016). There were no significant earthquakes that might have warned authorities in the lead up to the phreatic eruption, caused by ground water flashing to steam in a hydrothermal explosion. At the time of the eruption there was no operational geochemical surveillance program. In order to contribute to the strengthening of this program, the Disaster Mitigation Research Center of Nagoya University and the Volcanological Institute of Canary Islands started a collaborative program. To do so, an automatic geochemical station was installed at Ontake volcano and a survey of diffuse CO2efflux and other volatiles was carried out at the surface environment of selected areas of the volcano. The station was installed 10.9 km east away from the eruptive vent, where some earthquakes occurred, and consists of a soil radon (Rn) monitor (SARAD RTM-2010-2) able to measure 222Rn and 220Rn activities. Monitoring of radon is an important geochemical tool to forecast earthquakes and volcanic eruptions due to its geochemical properties. Rn ascends from the lower to the upper part of earth's crust mainly through cracks or faults and its transport needs the existence of a naturally occurring flux of a carrier gas. Regarding to the soil gas survey, it was carried out in August 2016 with 183 measurement points performed in an area of 136 km2. Measurements of soil CO2 efflux were carried out following the accumulation chamber method by means of a portable soil CO2 efflux instrument. To estimate the total CO2 output, sequential Gaussian simulation (sGs) was used allowing the interpolation of the measured variable at not-sampled sites and assess the uncertainly of the total diffuse emission of carbon dioxide estimated for the entire studied area

  17. Animal Models of Chemotherapy-induced Mucositis

    DEFF Research Database (Denmark)

    Sangild, Per T; Shen, René Liang; Pontoppidan, Peter Erik Lotko

    2018-01-01

    of CIM, and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e.g. GIT) insights, standardized, clinically-relevant treatment regimens and discovery of new biomarkers. Still, surprisingly few results from animal models have been translated into clinical CIM......Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs and several animal models of CIM have been developed to help understand the progression...... mangement and treatments. The results obtained from specific animal models can be difficult to translate to the diverse range of CIM manifestations in patients that vary according to the antineoplastic drugs, dose, underlying (cancer) disease and patient characteristics (e.g. age, genetics, body...

  18. Biomarkers for monitoring chemotherapy-induced cardiotoxicity.

    Science.gov (United States)

    Cao, Liyun; Zhu, Wuqiang; Wagar, Elizabeth A; Meng, Qing H

    2017-03-01

    Cardiotoxicity, including acute and late-onset cardiotoxicity, is a well-known adverse effect of many types of antitumor agents. Early identification of patients with cardiotoxicity is important to ensure prompt treatment and minimize toxic effects. The etiology of chemotherapy-induced cardiotoxicity is multifactorial. Traditional methods for assessment of chemotherapy-induced cardiotoxicity typically involve serial measurements of cardiac function via multi-modality imaging techniques. Typically, however, significant left ventricular dysfunction has already occurred when cardiotoxicity is detected by imaging techniques. Biomarkers, most importantly cardiac natriuretic peptides and troponins, are promising markers for identifying patients potentially at risk for clinical heart failure symptoms. This review summarizes the recent progress in clinical utilization of biomarkers for early diagnosis of acute cardiotoxicity and for prediction of late-onset cardiotoxicity. We also discuss the conflicting results of different studies and the association of results with study design.

  19. Enzalutamide in metastatic prostate cancer before chemotherapy

    DEFF Research Database (Denmark)

    Beer, Tomasz M; Armstrong, Andrew J; Rathkopf, Dana E

    2014-01-01

    BACKGROUND: Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate cancer in whom the disease has progressed after chemotherapy. New treatment options are needed for patients with metastatic prostate cancer who have...... the most common clinically relevant adverse events associated with enzalutamide treatment. CONCLUSIONS: Enzalutamide significantly decreased the risk of radiographic progression and death and delayed the initiation of chemotherapy in men with metastatic prostate cancer. (Funded by Medivation and Astellas...... skeletal-related event (hazard ratio, 0.72), a complete or partial soft-tissue response (59% vs. 5%), the time until prostate-specific antigen (PSA) progression (hazard ratio, 0.17), and a rate of decline of at least 50% in PSA (78% vs. 3%) (P

  20. Teratoid Wilms tumour with chemotherapy resistance

    Directory of Open Access Journals (Sweden)

    Renuka Gahine

    2015-01-01

    Full Text Available We present a case of Teratoid Wilms tumour (a rare histologic variant in a 4 year old male who presented with an abdominal lump. Wilms Tumour with paracaval lymphadenopathy and tumour thrombi in right renal vein and inferior vena cava was made radiologically. FNAC report was suggestive of Wilms tumour and patient was subjected to 6 cycles of chemotherapy with not much reduction in size. Post nephrectomy histological diagnosis of Teratoid Wilms tumour was established. Resistance to chemotherapy and radiotherapy is thought to be due to presence of well differentiated histologic appearance. Teratoid Wilms tumour is usually not an aggressive neoplasm and prognosis is comparatively neoplasm and prognosis is comparatively good if the tumour is excised completely thus surgery being the best treatment.

  1. Progress in Personalizing Chemotherapy for Bladder Cancer

    Directory of Open Access Journals (Sweden)

    James S. Chang

    2012-01-01

    Full Text Available Platinum-based chemotherapy is commonly used for the treatment of locally advanced and metastatic bladder cancer. However, there are currently no methods to predict chemotherapy response in this disease setting. A better understanding of the biology of bladder cancer has led to developments of molecular biomarkers that may help guide clinical decision making. These biomarkers, while promising, have not yet been validated in prospective trials and are not ready for clinical applications. As alkylating agents, platinum drugs kill cancer cells mainly through induction of DNA damage. A microdosing approach is currently being tested to determine if chemoresistance can be identified by measuring platinum-induced DNA damage using highly sensitive accelerator mass spectrometry technology. The hope is that these emerging strategies will help pave the road towards personalized therapy in advanced bladder cancer.

  2. PERIOPERATIVE CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC CANCER

    Directory of Open Access Journals (Sweden)

    Thales Paulo BATISTA

    2013-09-01

    Full Text Available Gastric cancer is one of the most common cancers and a main cause of cancer-related death worldwide, since the majority of patients suffering of this malignancy are usually faced with a poor prognosis due to diagnosis at later stages. In order to improve treatment outcomes, the association of surgery with chemo and/or radiotherapy (multimodal therapy has become the standard treatment for locally advanced stages. However, despite several treatment options currently available for management of these tumors, perioperative chemotherapy has been mainly accepted for the comprehensive therapeutic strategy including an appropriated D2-gastrectomy. This manuscript presents a (nonsystematic critical review about the use of perioperative chemotherapy, with a special focus on the drugs delivery.

  3. Endocrine consequences of irradiation and cancer chemotherapy

    International Nuclear Information System (INIS)

    Shalet, S.M.; Beardwell, C.

    1981-01-01

    A brief review is presented of endocrine dysfunction as a long-term effect of radiotherapy and cancer chemotherapy, with particular reference to children, and to Hodgkin's disease. The hypothalamus and pituitary, growth hormone and thyroid stimulating hormone, thyroid and parathyroid, and gonads are discussed. Suggestions are made for long-term measures to be taken, such as measuring growth rates, L-thyroxine replacement, sperm storage, etc. (U.K.)

  4. July 1993 Hokkaido, Japan Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — On July 12, 1993, a magnitude 7.6 Ms (7.7 Mw) (HRV) earthquake at 13:17 UT in the Sea of Japan near Hokkaido caused a back-arc tsunami that caused damage in all of...

  5. Medical Education in Japan, 1969

    Science.gov (United States)

    Brooks, Thomas J., Jr.

    1970-01-01

    Although Japan's 19th century feudalistic education system was abolished at the close of World War II and the country has wrought the greatest economic miracle in world history, the Japanese still assign low priorities to health and medical education. (IR)

  6. BWR Stability Issues in Japan

    Directory of Open Access Journals (Sweden)

    Hideaki Ikeda

    2008-01-01

    Full Text Available The present paper reviews activates relevant to the boiling water reactor (BWR stability phenomenon, which has a coupled neutronic and thermal-hydraulic nature, from the viewpoint of model and code developments and their applications to the BWR stability solution methodology in Japan.

  7. Entrepreneurship and unemployment in Japan

    NARCIS (Netherlands)

    van Stel, A.; Thurik, R.; Verheul, I.; Baljeu, L.

    2008-01-01

    We examine the relationship between entrepreneurship (as measured by fluctuations in the business ownership rate) and unemployment in Japan for the period between 1972 and 2002. We find that, although Japan’s unemployment rate has been influenced by specific exogenous shocks, the effects of

  8. Radioactivity survey data in Japan

    International Nuclear Information System (INIS)

    1981-09-01

    Strontium-90 and cesium-137 in Japan were determined in rain and dry fallout, airborne dust, service water, freshwater, soils, total diet, milk, vegetables, tea, sea fish, freshwater fish, shellfish, and seaweeds. The results were shown in tables. (J.P.N.)

  9. [Marriage and divorce in Japan].

    Science.gov (United States)

    Haderka, J

    1986-01-01

    Marriage patterns in Japan are analyzed using data from secondary sources. The author notes that although legislation affecting marriage and the family is derived from European models, traditional Japanese attitudes concerning the subservient role of women have a significant impact. The problems faced by women experiencing divorce are noted. (SUMMARY IN ENG AND RUS)

  10. JPRS Report. Science & Technology: Japan.

    Science.gov (United States)

    1988-12-09

    Acoustic performance of buildings, research on environmental psychology -Research on refuge, safety in times of disaster -Research and development of...Assigning Environmental Psychology Sector to Independent Laboratory Also Planned " Environmental psychology , for instance, is not something originally...plan to develop this environmental psychology sector further into an independent laboratory. Only in Japan is there a construction company that has

  11. Light water reactors in Japan

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The economy shifted to a low growth rate, and energy conservation advanced, accordingly, the growth rate of electric power demand is expected to be 3 %. As the result, nuclear power must be more economical. From the perspective of the national security, the continuous development of nuclear power is essential for Japan, as nuclear power is a quasi-domestically produced energy source, and Japan must reduce the dependence on oil. The commercial power plants in Japan are a gas-cooled reactor plant of 166 MW capacity, 16 BWR plants of 12,917 MW total capacity and 15 PWR plants of 11,438 MW total capacity, totaling 32 plants of 24,521 MW. Those in the construction or planning stage are 8 BWR plants of 8,245 MW and 8 PWR plants of 7,928 MW, totaling 16 plants of 16,173 MW. As of the end of March, 1986, nuclear power generating facilities were 16 % of the total facilities in Japan, which generated 26 % of the total electric power generated in fiscal year 1985. The capacity factor exceeded 70 % since 1982. The improvement and standardization program of LWRs and its results, the effort to develop ALWRs, the further advance in LWRs, the use of plutonium and so on are discussed. The further improvement of the economy and reliability of nuclear power plants is urgently required. (Kako, I.)

  12. Geothermal country update of Japan

    International Nuclear Information System (INIS)

    Higo, M.

    1990-01-01

    This paper reports on the status of geothermal energy in Japan. Topics covered include: present and planned production of electricity, present utilization of geothermal energy for direct heat, information about geothermal localities, and wells drilled for electrical utilization of geothermal resources to January 1, 1990

  13. Urban and spatial planning in Japan

    Directory of Open Access Journals (Sweden)

    Marin Tominaga

    2011-12-01

    Full Text Available This paper aims to introduce the urban and spatial planning inJapan. According to the national planning system of Japan, chapter 2, the planning system has 3 administrative levels and each territorial region has its own regulation. This paper introduces especially about planning and regulation system in city region in Japan.

  14. 75 FR 38119 - Polychloroprene Rubber From Japan

    Science.gov (United States)

    2010-07-01

    ... COMMISSION Polychloroprene Rubber From Japan AGENCY: United States International Trade Commission. ACTION: Institution of a five-year review concerning the antidumping duty finding on polychloroprene rubber from Japan... antidumping duty finding on polychloroprene rubber from Japan would be likely to lead to continuation or...

  15. Legislative Basis of Pedagogical Education in Japan

    Science.gov (United States)

    Kuchai, Tetiana

    2014-01-01

    Legal framework policy of Japan in the field of education has been analyzed. The problem of influence of legislative materials on the development of education in Japan, its legislative support has been considered. It has been defined that directive materials affect the development of education system in Japan. Legislation policy of the country is…

  16. Chemotherapy resistance mechanisms in advanced skin cancer

    Directory of Open Access Journals (Sweden)

    Bhuvanesh Sukhlal Kalal

    2017-03-01

    Full Text Available Melanoma is a most dangerous and deadly type of skin cancer, and considered intrinsically resistant to both radiotherapy and chemotherapy. It has become a major public health concern as the incidence of melanoma has been rising steadily over recent decades with a 5-year survival remaining less than 5%. Detection of the disease in early stage may be curable, but late stage metastatic disease that has spread to other organs has an extremely poor prognosis with a median survival of less than 10 months. Since metastatic melanoma is unresponsive to therapy that is currently available, research is now focused on different treatment strategies such as combinations of surgery, chemotherapy and radiotherapy. The molecular basis of resistance to chemotherapy seen in melanoma is multifactorial; defective drug transport system, altered apoptotic pathway, deregulation of apoptosis and/or changes in enzymatic systems that mediate cellular metabolic machinery. Understanding of alterations in molecular processes involved in drug resistance may help in developing new therapeutic approaches to treatment of malignant melanoma.

  17. Management of chemotherapy induced diarrhea (abstract)

    International Nuclear Information System (INIS)

    Qureshi, A.M.

    1998-01-01

    Diarrhoea is seen with many tumors and following several chemotherapy regimen esp. those containing 5-fluorouracil and high dose folinic acid it causes debility even death, delays cancer treatment, reduces compliance increases cost. It causes dehydration, renal failure volume depletion. Quality of life is worsened and hospitalization may be needed in multifactorial, with secretion; absorption imbalance due to mucosal damage, necrosis or inflammation. Local infection is set up by opportunistic organism and cell necrosis. The large volume of fluid and electrolytes overwhelms colonic absorptive capacity. Agent usually used for treatment is opioids (such as Diphenoxylate / Loperamide]. Bismuth (for inflammatory diarrhea). NSAIDs or alpha 2-agonists. For optimal management, the cause and severity should be assessed and treatment planned. Advice is given about certain dietary restraints and avoidance of some drugs. Fever, infection, dehydration and electrolyte losses are treated, pain relieved. Diphenoxylate / Loperamide (later is more effective; 4 mg, STAT, then 2mg every 4 hours or even 2 hourly) may be used. It is moderately effective in CID. Octreotide is useful in carcinoid. VIPoma, AIDS idiopathic secretary diarrhea, ileostomy, dumping syndrome. It acts directly on epithelial cells to reduce secretin, motilin pancreatic polypeptide. It slows transit time, reduces fluid and electrolyte secretin, increases absorption of electrolytes. It is effective in 5 FU and high dose chemotherapy with a 90% response rates seen after 3 days treatment. High Dose Chemotherapy and total body irradiation - induced diarrhea usually resolves within 72 hours. (author)

  18. Protocolo de Nagoya sobre acceso a los recursos genéticos y participación justa y equitativa en los beneficios que se deriven de su utilización: cuatro retos para su implementación nacional en países de América Latina y el Caribe

    Directory of Open Access Journals (Sweden)

    Mónica Ribadeneira Sarmiento

    2014-12-01

    Full Text Available El Protocolo de Nagoya sobre Acceso a los Recursos Genéticos y Participación Justa y Equitativa en los Beneficios que se Deriven de su Utilización es el instrumento internacional que desarrolla el tercer objetivo del Convenio sobre la Diversidad Biológica con la finalidad de que el acceso sea transparente, ágil y en términos equitativos. En el artículo se resume el proceso, que duró casi una década, que tomaron las negociaciones internacionales y se analizan los principales elementos del Protocolo. Para los países de América Latina y el Caribe la implementación del Protocolo de Nagoya representa varios retos; este artículo aborda cuatro de ellos: dos estrictamente legales, uno de nivel general (el desarrollo de regímenes nacionales, un segundo aplicable al régimen marino, un tercer reto de carácter preventivo de actividades no autorizadas y biopiratería, y el último relativo al fomento de la investigación científica.

  19. Urgent Safety Measures in Japan after Great East Japan Earthquake

    International Nuclear Information System (INIS)

    Taniura, Wataru; Otani, Hiroyasu

    2012-01-01

    Due to tsunami triggered by the Great East Japan Earthquake, the operating and refueling reactor facilities at Fukushima Dai-ichi and Dai-ni Nuclear Power Plants caused a nuclear hazard. Given the fact, Japanese electric power companies voluntarily began to compile various urgent measures against tsunami. And then the Nuclear and Industrial Safety Agency (NISA) ordered the licensees to put into practice the voluntarily compiled urgent safety measures, in order to ensure the effectiveness of the means for recovering cooling functions along with avoiding the release of radioactive substances to the possible minimum, even if a huge tsunami following a severe earthquake hits nuclear power plants. The following describes the state and the effect of the urgent safety measures implemented for 44 reactors (under operation) and 1 reactor (under construction) in Japan and also describes the measures to be implemented by the licensees of reactor operation in the future.

  20. Japan`s refiner/marketers headed for major shakeout

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-26

    Japan`s downstream oil industry is in a state of crisis and headed for a major shakeout. The major catalyst for this was a dramatic deregulation step during April 1996 that allowed refined petroleum product imports by non-refiners. The move, together with a sharp drop in refining margins, falling retail gasoline prices, and a service station sector on the brink of collapse, are all leading to massive changes in the way the country`s refiners and marketers do business. This paper reviews the collapse of corporate profits during this period of deregulation; the development of a new price system geared toward bringing the prices of gasoline, fuel oil, and kerosene into line with each other to offset the fall in gasoline prices; and industry restructuring including mergers, acquisitions, and marketing consolidation. The paper then makes predictions on the outcome of these changes on the Japanese oil industry.

  1. Palliative Chemotherapy Affects Aggressiveness of End-of-Life Care.

    Science.gov (United States)

    Wu, Chin-Chia; Hsu, Ta-Wen; Chang, Chun-Ming; Lee, Cheng-Hung; Huang, Chih-Yuan; Lee, Ching-Chih

    2016-06-01

    Although palliative chemotherapy during end-of-life care is used for relief of symptoms in patients with metastatic cancer, chemotherapy may lead to more aggressive end-of-life care and less use of hospice service. This is a population-based study of the association between palliative chemotherapy and aggressiveness of end-of-life care. Using the National Health Insurance Research Database of Taiwan, we identified 49,920 patients with metastatic cancer who underwent palliative chemotherapy from January 1, 2009, to December 31, 2011. Patients who received chemotherapy 2-6 months before death were included. Aggressiveness of end-of-life care was examined by previously reported indicators. Cardiopulmonary resuscitation and endotracheal tube intubation were included as indicators of aggressive end-of-life care. The association between palliative chemotherapy and hospice care was studied. Palliative chemotherapy was associated with more aggressive treatment. After adjustment for patient age, sex, Charlson Comorbidity Index score, cancer group, primary physician's specialty, postdiagnosis survival, hospital characteristics, hospital caseload, urbanization, and geographic regions, more than one emergency room visit (p care unit admission (p life care were significantly more common in patients receiving palliative chemotherapy. Patients who did not receive palliative chemotherapy received more hospice care in the last 6 months of life (p life care, including more emergency room visits and intensive care unit admissions, and endotracheal intubation. The patients who received palliative chemotherapy received less hospice service toward the end of life. Palliative chemotherapy is used for patients with incurable cancer toward the end of life (EOL). Aggressiveness of EOL care and hospice care are related to the quality of life of these patients. This study of data from the Taiwanese National Health Insurance Research Database found that palliative chemotherapy led to more

  2. Granulocyte colony stimulating factor priming chemotherapy is more effective than standard chemotherapy as salvage therapy in relapsed acute myeloid leukemia.

    Science.gov (United States)

    Shen, Ying; He, Aili; Wang, Fangxia; Bai, Ju; Wang, Jianli; Zhao, Wanhong; Zhang, Wanggang; Cao, Xingmei; Chen, Yinxia; Liu, Jie; Ma, Xiaorong; Chen, Hongli; Feng, Yuandong; Yang, Yun

    2017-12-29

    To improve the complete remission (CR) rate of newly diagnosed acute myeloid leukemia (AML) patients and alleviate the severe side effects of double induction chemotherapy, we combined a standard regimen with granulocyte colony-stimulating factor (G-CSF) priming chemotherapy to compose a new double induction regimen for AML patients who failed to achieve CR after the first course. Ninety-seven patients with AML who did not achieve CR after the first course of standard chemotherapy were enrolled. Among them, 45 patients received G-CSF priming combined with low-dose chemotherapy during days 20-22 of the first course of chemotherapy, serving as priming group, 52 patients were administered standard chemotherapy again, serving as control group. Between the two groups there were no differences in the French-American-British (FAB) classification, risk status, the first course of chemotherapy, blood cell count or blasts percentage of bone marrow before the second course. But the CR rate was significantly higher and the adverse effect was much lower in the priming group than the control group. Cox multivariate regression analysis showed that WBC level before the second course and the selection of the second chemotherapy regimen were two independent factors for long survival of patients. These results elucidate that standard chemotherapy followed by G-CSF priming new double induction chemotherapy is an effective method for AML patients to improve CR rate and reduce adverse effects. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  3. Another Neolithic in Holocene Japan

    Directory of Open Access Journals (Sweden)

    Masaki Nishida

    2002-12-01

    Full Text Available In the Japanese Islands, small sedentary villages sustained by hunting, gathering, fish- ing and cultivation emerged around 10 000 years ago. This life style of the Jomon people continued for around 7000 years without any drastic changes in material culture, subsistence strategy and vil- lage size until the diffusion of continental civilization into Japan approximately 2500 years ago. This indicates that the incipient sedentary society of the Jomon Period was very stable, a state which is not indicative of civilized society after that time. After the prehistoric situation in Japan, we are able to classify sedentary society into two phases; sedentism with stability and sedentism with instability (civilized society. Therefore it is possible to say that the emergence of sedentism and cultivation are not direct factors which promote the emergence of civilization.

  4. WDC Activities in Japan, 2008

    Directory of Open Access Journals (Sweden)

    Takashi Watanabe

    2009-06-01

    Full Text Available This paper briefly reviews the activities of the International Council for Science (ICSU World Data Centers (WDCs in Japan at a time of great change in the data and information structures of the ICSU ? the creation of the World Data System (WDS in 2009. Seven WDCs are currently operating in Japan: the WDC for Airglow, the WDC for Cosmic Rays, the WDC for Geomagnetism, Kyoto, the WDC for Ionosphere, the WDC for Solar Radio Emission, and the WDC for Space Science Satellites. Although these WDCs are highly active, along-term support system must be established to ensure the stewardship and provision of quality-assessed data and data services to the international science community.

  5. Japan reforms its nuclear safety

    International Nuclear Information System (INIS)

    Anon.

    2013-01-01

    The Fukushima Daiichi NPP accident deeply questioned the bases of nuclear safety and nuclear safety regulation in Japan. It also resulted in a considerable loss of public confidence in the safety of nuclear power across the world. Although the accident was caused by natural phenomena, institutional and human factors also largely contributed to its devastating consequences, as shown by the Japanese Diet's and Government's investigation reports. 'Both regulators and licensees were held responsible and decided to fully reconsider the existing approaches to nuclear safety. Consequently, the regulatory system underwent extensive reform based on the lessons learned from the accident,' Yoshihiro Nakagome, the President of Japan Nuclear Energy Safety Organisation, an ETSON member TSO, explains. (orig.)

  6. Fruit harvesting robots in Japan.

    Science.gov (United States)

    Kondo, N; Monta, M; Fujiura, T

    1996-01-01

    We have developed harvesting robots for tomato, petty-tomato, cucumber and grape in Japan. These robots mainly consist of manipulators, end-effectors, visual sensors and traveling devices. These mechanisms of the robot components were developed based on the physical properties of the work objects. The robots must work automatically by themselves in greenhouses or fields, since we are considering for one operator to tend several robots in the production system. The system is modeled after Japanese agriculture which is commonly seen to produce many kinds of crops in greenhouses and in many small fields intensively. Bioproduction in space is somewhat similar to the agricultural system in Japan, because few operators have to work in a small space. Employing robots for bioproduction in space is considered desirable in near future. The following is a description of the harvesting robots.

  7. Accelerator business in Japan expanding

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Accelerators have become to be used increasingly in Japan in such fields as medicine, physics research and industry. This has caused stiff competition for market share by the manufacturers of accelerators. Electron beam accelerators for industrial use provide an indispensable means for adding values to products, for example, electric cables with incombustible insulators. Linear accelerators for the nondestructive inspection of nuclear components have been widely installed at equipment manufacturing plants. Active efforts have been exerted to develop small synchrotron radiation accelerators for next generation electronic industry. Cyclotrons for producing short life radioisotopes for medical diagnosis and electron beam accelerators for radiation therapy are also used routinely. The suppliers of accelerators include the companies manufacturing heavy electric machinery, heavy machinery and the engineering division of steelmakers. Accelerator physics is being formed, but universities do not yet offer the course regarding accelerators. Accelerator use in Japan and the trend of accelerator manufacturers are reported. (K.I.)

  8. Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life.

    Science.gov (United States)

    Kataoka, Hiromi; Shimura, Takaya; Mizoshita, Tsutomu; Kubota, Eiji; Mori, Yoshinori; Mizushima, Takashi; Wada, Tsuneya; Ogasawara, Naotaka; Tanida, Satoshi; Sasaki, Makoto; Togawa, Shozo; Sano, Hitoshi; Hirata, Yoshikazu; Ikai, Masahiro; Mochizuki, Hisato; Seno, Kyoji; Itoh, Sachie; Kawai, Takashi; Joh, Takashi

    2009-01-01

    Lentinan (LNT), a purified beta-glucan, is a biological and immunological modifier and has been used as an anticancer drug in combination with 5-fluorouracil for gastric cancer in Japan. In this prospective randomized study, we evaluated the effects of LNT combination with regard to quality of life (QOL) and LNT binding ratio in monocytes. Twenty patients were evaluated for 12 weeks. One cycle was 3 weeks and S-1 (day1-14) and Paclitaxel (days1 and 8) were administered. LNT was used once a week (days 1, 8 and 15) and it was used for all 12 weeks in the LNT 12-wk group and only for the last 6 weeks in the LNT 6-wk group. QOL was evaluated weekly by QOL-ACD, and binding of LNT to monocytes was measured by flow cytometry. There were individual variations in the binding ratio of LNT to monocytes from 0.16% to 11.95%. Toxicity with chemotherapy was not improved in the LNT 12-wk group, however, the total QOL score was significantly elevated in the LNT 12-wk group (p = 0.018) but not in the LNT 6-wk group. LNT combination from the beginning of the chemotherapy may be an important factor for the improvement of patient QOL.

  9. Estimation of 222Rn flux and its effect on the atmospheric 222Rn concentration at Hachijo-jima Island, Japan

    International Nuclear Information System (INIS)

    Ohkura, Takehisa; Yamazawa, Hiromi; Moriizumi, Jun; Hirao, Shigekazu; Iida, Takao

    2010-01-01

    222 Rn fluxes from the ground surface and 226 Ra contents in soil were measured on Hachijo-jima Island, which is a solitary island in the Pacific Ocean located about 200 km to the south of the main island of Japan, to evaluate fractional contributions of the locally exhaled 222 Rn and the long-range transported one to the surface air concentration measured on this island. Averages of 222 Rn flux and 226 Ra content in dry soil were evaluated to be 0.9±0.4 mBq m -2 s -1 and 6.8±0.2 Bq kg -1 , respectively. These are considerably smaller than the respective values of 9.7±0.8 mBq m -2 s -1 and 23.2±0.4 Bq kg -1 measured at Nagoya as a reference. The lower value of the 226 Ra content and the even lower 222 Rn flux on this island can be attributed to the basaltic geology and the soil's coarse texture moisture, respectively. A simple model calculation assuming a typical nocturnal condition showed that the measured 222 Rn flux would cause only a small increase in the surface air concentration by 0.035 to 0.072 Bq m -3 (relative contribution of 1 to 12%) in addition to the long-range transported 222 Rn under a typical nocturnal condition. The contribution of the local flux would be smaller than that under nocturnal condition. This local 222 Rn component is negligible as compared with the concentration of the long-range transported 222 Rn (0.6 to 3.6 Bq m -3 ). It is, therefore, concluded that Hachijo-jima Island is suitable for measuring the long-range transported atmospheric 222 Rn in East Asia region. (author)

  10. Adjuvant chemotherapy for rectal cancer: Is it needed?

    Science.gov (United States)

    Milinis, Kristijonas; Thornton, Michael; Montazeri, Amir; Rooney, Paul S

    2015-01-01

    Adjuvant chemotherapy has become a standard treatment of advanced rectal cancer in the West. The benefits of adjuvant chemotherapy after surgery alone have been well established. However, controversy surrounds the use adjuvant chemotherapy in patients who received preoperative chemoradiotherapy, despite it being recommended by a number of international guidelines. Results of recent multicentre randomised control trials showed no benefit of adjuvant chemotherapy in terms of survival and rates of distant metastases. However, concerns exist regarding the quality of the studies including inadequate staging modalities, out-dated chemotherapeutic regimens and surgical approaches and small sample sizes. It has become evident that not all the patients respond to adjuvant chemotherapy and more personalised approach should be employed when considering the benefits of adjuvant chemotherapy. The present review discusses the strengths and weaknesses of the current evidence-base and suggests improvements for future studies. PMID:26677436

  11. [Nursing care for ovarian cancer patients with intraperitoneal chemotherapy].

    Science.gov (United States)

    Lu, Yu-Ying; Chou, Ju-Fen; Tsao, Lee-Ing; Liang, Shu-Yuan; Wu, Shu-Fang

    2015-02-01

    Ovarian cancer, known as a "silent killer", is the leading cause of gynecologic cancer death. Standard treatments for ovarian cancer are debulking surgery combined with platinum chemotherapy drugs to prolong the survival of patients. According to clinical trials run by the American Society of Gynecologic Oncology, patients who received intraperitoneal (IP) chemotherapy survived longer on average than patients who received intravenous chemotherapy alone. Thus, intraperitoneal chemotherapy is a new potential approach for treating ovarian cancer patients. However, the toxicities and undesirable complications of IP chemotherapy are the major challenges of this treatment approach. This article helps nurses recognize the toxicities and complications of IP chemotherapy and may be used as reference for future revisions to patient care guidelines.

  12. Toshiba viste os Japans svaghed

    DEFF Research Database (Denmark)

    Thomsen, Steen

    2015-01-01

    Corporate governance (selskabsledelse, red.) er blevet moderne i Japan som led i Shinzo Abe-regeringens forsøg på at revitalisere landets økonomi. Krav om øget rentabilitet gjorde det endnu sværere at indrømme problemerne. Direktøren tager skyldenI en dansk eller amerikansk virksomhed ville en ny......- kelige til at kickstarte aktiemarkedet og den økonomiske vækst....

  13. Japan: 45 Years of INIS

    International Nuclear Information System (INIS)

    Yonezawa, Minoru

    2015-01-01

    I would like to congratulate INIS on its 45th anniversary. Japan is a founding member of this international cooperation program, and the Japan Atomic Energy Agency (formerly, Japan Atomic Energy Research Institute — JAERI) was appointed as the national center of INIS by the Japanese government. We have contributed to the collection, classification, indexing, abstracting and submission of nuclear literature published in our country, as well as promoted the INIS database within our country. I have been engaged in INIS activities for many years and have a lot of experience with INIS. On the occasion of INIS’ 45th anniversary, I would like to look back on this experience. I started my career at JAERI in 1984. The first regional training seminar for the Far East was held in Tokyo in October 1984. I was assigned to the Library Division of JAERI, but I worked as support staff for the regional training seminar. During the seminar, I had an opportunity to attend the technical tour with the seminar participants to the University of Library and Information Science, research laboratories, etc., in Tsukuba Science City. This was my first involvement with INIS. It was a very impressive and interesting experience

  14. Aerial measuring system in Japan.

    Science.gov (United States)

    Lyons, Craig; Colton, David

    2012-05-01

    The U.S. Department of Energy/National Nuclear Security Administration's (DOE/NNSA) Aerial Measuring System (AMS) deployed personnel and equipment to partner with the U.S. Forces in Japan (USFJ) to conduct multiple aerial radiological surveys. These were the first and most comprehensive sources of actionable information for U.S. interests in Japan and provided early confirmation to the Government of Japan as to the extent of the release from the Fukushima Daiichi Nuclear Power Plant. Many challenges were overcome quickly during the first 48 h, including installation and operation of Aerial Measuring System equipment on multiple USFJ aircraft, flying over difficult terrain, and flying with USFJ pilots who were unfamiliar with the Aerial Measuring System flight patterns. These factors combined to make for a programmatically unanticipated situation. In addition to the challenges of multiple and ongoing releases, integration with the Japanese government to provide valid aerial radiological survey products that both military and civilian customers could use to make informed decisions was extremely complicated. The Aerial Measuring System Fukushima response provided insight into addressing these challenges and gave way to an opportunity for the expansion of the Aerial Measuring System's mission beyond the borders of the U.S.

  15. Chemotherapy Use at the End of Life in Uganda.

    Science.gov (United States)

    Low, Daniel; Merkel, Emily C; Menon, Manoj; Lyman, Gary H; Ddungu, Henry; Namukwaya, Elizabeth; Leng, Mhoira; Casper, Corey

    2017-12-01

    Purpose Avoiding chemotherapy during the last 30 days of life has become a goal of cancer care in the United States and Europe, yet end-of-life chemotherapy administration remains a common practice worldwide. The purpose of this study was to determine the frequency of and factors predicting end-of-life chemotherapy administration in Uganda. Methods Retrospective chart review and surveys and interviews of providers were performed at the Uganda Cancer Institute (UCI), the only comprehensive cancer center in the area, which serves a catchment area of greater than 100 million people. All adult patients at the UCI with reported cancer deaths between January 1, 2014, and August 31, 2015 were included. All UCI physicians were offered a survey, and a subset of physicians were also individually interviewed. Results Three hundred ninety-two patients (65.9%) received chemotherapy. Age less than 55 years (odds ratio [OR], 2.30; P = .004), a cancer diagnosis greater than 60 days before death (OR, 9.13; P < .001), and a presenting Eastern Cooperative Oncology Group performance status of 0 to 2 (OR, 2.47; P = .001) were associated with the administration of chemotherapy. More than 45% of patients received chemotherapy in the last 30 days of life. No clinical factors were predictive of chemotherapy use in the last 30 days of life, although doctors reported using performance status, cancer stage, and tumor chemotherapy sensitivity to determine when to administer chemotherapy. Patient expectations and a lack of outcomes data were important nonclinical factors influencing chemotherapy administration. Conclusion Chemotherapy is administered to a high proportion of patients with terminal cancer in Uganda, raising concern about efficacy. Late presentation of cancer in Uganda complicates end-of-life chemotherapy recommendations, necessitating guidelines specific to sub-Saharan Africa.

  16. Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma

    OpenAIRE

    Saito, Yuki; Ando, Mizuo; Omura, Go; Yasuhara, Kazuo; Yoshida, Masafumi; Takahashi, Wataru; Yamasoba, Tatsuya

    2016-01-01

    Objectives/Hypothesis We aimed to determine the effectiveness of induction chemotherapy for treating p16?positive oropharyngeal cancer in our department. Study Design This was a retrospective case series to assess treatment effectiveness. Methods We administered induction chemotherapy to patients with stage III to IV oropharyngeal p16?positive squamous cell carcinoma between 2008 and 2013. Induction chemotherapy was administered using combinations of docetaxel, cisplatin, and 5?fluorouracil. ...

  17. Nursing actions facing reactions to chemotherapy in oncological patients

    OpenAIRE

    Guimarães, Rita de Cássia Ribeiro; Gonçalves, Renata Patrícia Fonseca; Lima, Cássio de Almeida; Torres, Marcelo Rocha; Silva, Carla Silvana de Oliveira e

    2015-01-01

    Objective: Describing the action of nursing facing the chemotherapy reactions in oncological patients. Method: Integrated review of literature of 14 scientific articles published in the last 10 years. Results: The adverse reactions inherent to the chemotherapy treatment manifested by the patients are frequent. Nausea and vomit were the main reactions described in chemotherapy. The nursing job is developed through the orientation before and during the treatment and has as an primordial objecti...

  18. FBIS report. Science and technology: Japan, December 10, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-10

    Contents (partial): Japan: Fabrication of Diamond Single Crystal Thin Film by Ion Beam Deposition; Japan: Hitachi Metal Develops New Semi Solid Metal Processing Technology; Japan: NTT Develops Fuel Cell System That Uses Both City Gas, LPG; Japan: Daihatsu Motor Completes Prototype EV; Japan: NIRIM Announces Success With Synthetic Bone Development; Japan: Sandoz Pharmaceuticals Plans Clinical Trials of Gene Therapy to Cerebral Tumor in Japan; Japan: MITI To Provide Aid for Residential Solar Power Generation Systems; Japan: MELCO To Provide Satellite Solar Cell Panel for SSL, USA; Japan: Japan Atomic Energy Research Institute Leads Nuclear Research; Japan: Kobe Steel`s Superconducting Magnet Ready to Go Fast; Japan: MPT To Begin Validation Test for Electric Money Implementation; and Japan: Defense Agency to Send ASDF`s Pilots to Russia for Training.

  19. Pregabalin in chemotherapy induced neuropathic pain

    Directory of Open Access Journals (Sweden)

    Shrikant Atreya

    2016-01-01

    Full Text Available Chemotherapeutic agents belonging to vinca alkaloids, taxanes, and antitubulins produce peripheral neuropathy for which there is no validated treatment. Pregabalin, a gamma-aminobutyric acid analog, is known to inhibit theα2δ subunit of the voltage-gated calcium channel. Earlier studies and case reports have shown pregabalin to be effective in treating neuropathic pain. We present a case series of patients with chemotherapy-induced peripheral neuropathy who were successfully treated with pregabalin with reduction in the hyperalgesia, allodynia, and improvement in the quality of life.

  20. Improving documentation of oral chemotherapy at a community cancer center.

    Science.gov (United States)

    Enright, Katherine; MacMillan, Meghan; Lymburner, Patricia; Sodoski, Catherine; Gollee, Simerjit; Carvalho, Maritza; Van Dorn, Laurie; Fung, Ron; Almeida, Bernadette

    2015-05-01

    Safe administration of oral chemotherapy is a complex process that represents a potential threat to patient safety. Clear documentation of the plan of care for patients receiving oral chemotherapy can improve patient safety by ensuring complete health information is available to the health care team. We undertook a rapid-cycle improvement project to improve documentation of oral chemotherapy by increasing the number of components of an oral chemotherapy care plan (as outlined by American Society of Clinical Oncology and Oncology Nursing Society) documented in the medical record before starting a new oral chemotherapy drug. Three improvement cycles were implemented, including: introduction of a standardized nursing flow sheet, use of computerized physician order entry for oral chemotherapy prescribing, and a review of computerized physician order entry to ensure all oral chemotherapy regimens were included. Our intervention resulted in a meaningful and sustained improvement in the number of components of oral chemotherapy care plans documented in the medical record, from a mean of 67% (eight of 12 components) to a mean of 92% (11 of 12). We are hopeful that this improvement project will enhance patient safety by improving communication within the health care team regarding the details of the chemotherapy care plan. Copyright © 2015 by American Society of Clinical Oncology.

  1. Acute constipation in children receiving chemotherapy for cancer.

    Science.gov (United States)

    Pashankar, Farzana D; Season, J Hale; McNamara, Joseph; Pashankar, Dinesh S

    2011-10-01

    Constipation occurs in children receiving chemotherapy for cancer but there are no data about prevalence, risk factors, and severity of constipation in this group of children. We prospectively studied 61 children receiving chemotherapy for cancer. We administered questionnaires to children and parents and collected data on demographics, chemotherapy, and bowel movement pattern during chemotherapy. We used North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition criteria for the diagnosis of constipation. Parental perception of constipation as a problem and impact on lifestyle during chemotherapy were assessed on a 0 to 3 scale with 0 being no problem, 1 minor, 2 significant, and 3 being a major problem. Thirty-five children (57%) had acute constipation lasting for 2 or more weeks during chemotherapy. Several risk factors were analyzed and only combined use of vincristine and opiates emerged as significant risk factor for the development of constipation. In children with constipation, 15 of 35 parents (43%) perceived constipation as a major/significant problem and 8 children and their parents (23%) perceived constipation having a major/significant impact on lifestyle during chemotherapy. Acute constipation was diagnosed in 57% of children receiving chemotherapy for cancer. Combined use of vincristine and opiates was associated with the development of constipation. Constipation can be a significant problem with a negative impact on lifestyle during chemotherapy and needs aggressive management.

  2. The role of intravitreal chemotherapy for retinoblastoma

    Directory of Open Access Journals (Sweden)

    Fairooz P Manjandavida

    2015-01-01

    Full Text Available Targeted therapy in retinoblastoma (RB is widely accepted as the current management tool with an aim of increasing drug availability at the tumor location. Inevitably the effect is several times higher compared to systemic delivery of chemotherapeutic drugs and carries less systemic toxicity. Despite tremendous advancement in saving life, eye salvage in advanced RB especially with active vitreous seeds remains a challenge. The hypoxic environment of the vitreous and reduced vitreous concentration of the drugs delivered makes these tumor seeds resistant to chemotherapy. Direct delivery of chemotherapeutic drugs into the vitreous cavity aids to overcome these challenges and is progressively being accepted worldwide. However, intraocular procedure in RB was abandoned due to high risk of extraocular tumor dissemination. Recently, the forbidden therapeutic technique was re-explored and modified for safe use. Although eye salvage rate has tremendously improved after intravitreal chemotherapy (IVitC, retinal toxicity, and vision salvage are yet to be validated. In our preliminary report of intravitreal melphalan in 11 eyes, we reported 100% eye salvage and 0% recurrence with an extended 15 months mean follow-up. In this review, we analyzed published reports on IVitC in RB via PubMed, Medline, and conference proceedings citation index, electronic database search, without language restriction that included case series and reports of humans and experimental animal eyes with RB receiving IVitC.

  3. Drug cocktail optimization in chemotherapy of cancer.

    Directory of Open Access Journals (Sweden)

    Saskia Preissner

    Full Text Available BACKGROUND: In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP. Furthermore, a number of important chemotherapeutic drugs such as cyclophosphamide, ifosfamide, tamoxifen or procarbazine are administered as prodrugs and have to be activated by CYP. Therefore, the genetic variability of these enzymes should be taken into account to design appropriate therapeutic regimens to avoid inadequate drug administration, toxicity and inefficiency. OBJECTIVE: The aim of this work was to find drug interactions and to avoid side effects or ineffective therapy in chemotherapy. DATA SOURCES AND METHODS: Information on drug administration in the therapy of leukemia and their drug metabolism was collected from scientific literature and various web resources. We carried out an automated textmining approach. Abstracts of PubMed were filtered for relevant articles using specific keywords. Abstracts were automatically screened for antineoplastic drugs and their synonyms in combination with a set of human CYPs in title or abstract. RESULTS: We present a comprehensive analysis of over 100 common cancer treatment regimens regarding drug-drug interactions and present alternatives avoiding CYP overload. Typical concomitant medication, e.g. antiemetics or antibiotics is a preferred subject to improvement. A webtool, which allows drug cocktail optimization was developed and is publicly available on http://bioinformatics.charite.de/chemotherapy.

  4. Incomplete copolymer degradation of in situ chemotherapy.

    Science.gov (United States)

    Bourdillon, Pierre; Boissenot, Tanguy; Goldwirt, Lauriane; Nicolas, Julien; Apra, Caroline; Carpentier, Alexandre

    2018-02-17

    In situ carmustine wafers containing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) are commonly used for the treatment of recurrent glioblastoma to overcome the brain-blood barrier. In theory, this chemotherapy diffuses into the adjacent parenchyma and the excipient degrades in maximum 8 weeks but no clinical data confirms this evolution, because patients are rarely operated again. A 75-year-old patient was operated twice for recurrent glioblastoma, and a carmustine wafer was implanted during the second surgery. Eleven months later, a third surgery was performed, revealing unexpected incomplete degradation of the wafer. 1H-Nuclear Magnetic Resonance was performed to compare this wafer to pure BCNU and to an unused copolymer wafer. In the used wafer, peaks corresponding to hydrophobic units of the excipient were no longer noticeable, whereas peaks of the hydrophilic units and traces of BCNU were still present. These surprising results could be related to the formation of a hydrophobic membrane around the wafer, thus interfering with the expected diffusion and degradation processes. The clinical benefit of carmustine wafers in addition to the standard radio-chemotherapy remains limited, and in vivo behavior of this treatment is not completely elucidated yet. We found that the wafer may remain after several months. Alternative strategies to deal with the blood-brain barrier, such as drug-loaded liposomes or ultrasound-opening, must be explored to offer larger drug diffusion or allow repetitive delivery.

  5. [Cardiologic evaluation of patients undergoing chemotherapy].

    Science.gov (United States)

    Bordoni, Barbara; Urbinati, Stefano; Tosoni, Alicia; Labanti, Graziana; Brandes, Alba

    2014-06-01

    Life expectancy in patients affected by cancer has recently increased because of early diagnosis and actual therapies. In recent years, Oncology and Cardiology developed a tight relationship because of common risk factors (i.e., obesity, smoking, alcool intake, etc...), and for preventing the prothrombotic status due to cancer and the potential cardiotoxicity of chemotherapy. Cardiotoxicity incidence is reported from 1% up to 70% in retrospective analyses of drug protocols, mainly representing by left ventricular dysfunction (both reversible or irreversible), but also by arrhythmias, hypertension, atrioventricular block, coronary spasm, and arterial or venous thromboembolism. The early detection of the chemoterapy induced cardiotoxicity is now mandatory and can be obtained through a proper patients selection for different treatments and a strict monitoring during the follow-up period. The role of biomarkers of early cardiac damage, mainly, troponin I and brain natriuretic peptide-BNP, has been recently challenged, and algorithms are currently available. In the present paper, we propose how to perform a cardiological evaluation of patients undergoing chemotherapy tailored by the known adverse effects of the drugs.

  6. Simultaneous radio-chemotherapy in esophageal carcinoma

    International Nuclear Information System (INIS)

    Tosch, U.; Wendt, T.G.; Rohloff, R.; Willich, N.

    1988-01-01

    Between 1983 and 1986, 41 patients with a squamous cell carcinoma of the esophagus without hematogenic metastases were treated with a combination of radio- and chemotherapy preoperatively. Treatment consisted of mitomycin C (10 mg/sqm/day 1) and continuous infusion of 5 fluorouracil (1000 mg/sqm/day - day 1 to 4) with a maximum of 1500 mg per day. On day 2 radiotherapy was started. After the administration of 36 Gy all patients were restaged. Nine patients were referred to surgery. In 13 cases surgery was refused, because of inoperability, due to local or distant metastases. In these patients radiotherapy was continued up to 50 to 60 Gy for palliation. Although the disease was confined to the esophagus no surgery was performed in 19 patients, because of age, enhanced risk of anaesthesia or refusal by the patient. These patients were treated with radiotherapy alone (60 Gy) with curative intention. 32 patients treated without surgery were followed up. For the patients treated with curative intent, the one year survival rate was 62%, the two year survival rate was 42%. Compared to a group treated in 1970 to 1982 with the same dosage of irradiation without the combination of chemotherapy the median survival could be raized from nine to 24 months, the two year survival rate improved from 18% to 42%. Patients treated for palliation only did not survive the first year after therapy. (orig.) [de

  7. Japan's hidden youths: mainstreaming the emotionally distressed in Japan.

    Science.gov (United States)

    Borovoy, Amy

    2008-12-01

    One of the most talked-about social issues in Japan in recent years has been the problem of the nation's purportedly one million "hidden" youths, known as hikikomori (literally, "the withdrawn"). Most observers agree that the category of hikikomori encompasses a wide range of problems and provocations. The fact that these various dilemmas lead to the shared outcome of shutting oneself away at home is the point of departure here. The article explores the spheres of mental health care, education and family, focusing on the reluctance to highlight underlying psychological dimensions of hikikomori and the desire on the part of schools and families to "mainstream" Japanese children, accommodating as many as possible within standardized public education. Hikikomori can perhaps be seen as a manifestation of Japanese democracy, in which the good society is imagined as cohesive, protective and secure, rather than one in which the individual can freely exercise the right to be different. Schools, families and the sphere of mental health care have focused on producing social inclusion but have discouraged citizens from being labeled as "different" -- even when such a distinction might help them. The dearth of facilities and discourse for caring for the mentally ill or learning disabled is, in many respects, the darker side of Japan's successes. Those who cannot adjust are cared for through the institutions of families, companies and various other spheres that offer spaces to rest and to temporarily "drop out"; however, the expectation is that rest will eventually lead to a re-entry into mainstream society. Often the psychological problem or disability that led to the problem goes unnamed and untreated (hikikomori, psychiatry, special education, youth, family, Japan).

  8. Efficacy of Scalp Cooling in Preventing Chemotherapy-Induced Alopecia in Breast Cancer Patients Receiving Adjuvant Docetaxel and Cyclophosphamide Chemotherapy.

    Science.gov (United States)

    Cigler, Tessa; Isseroff, Devora; Fiederlein, Barbara; Schneider, Sarah; Chuang, Ellen; Vahdat, Linda; Moore, Anne

    2015-10-01

    Chemotherapy-induced alopecia (CIA) is a distressing adverse effect of many chemotherapy agents. The TC (docetaxel [Taxotere] and cyclophosphamide) chemotherapy regimen is typically associated with complete alopecia. Scalp cooling with cold caps has been reported to minimize or prevent CIA. We conducted a prospective study to assess efficacy of scalp cooling in preventing CIA among women receiving adjuvant TC chemotherapy for breast cancer. Women at the Weill Cornell Breast Center who independently elected to use scalp cooling with cold caps during adjuvant TC chemotherapy were asked to participate. Degree of hair loss was assessed by a single practitioner using Dean's alopecia scale (grade 1/excellent [ 75% hair loss]), by digital photographs, and by patient self-report of hair thinning or the need to wear a wig/head covering, or both. Assessments were made before each chemotherapy treatment and at follow-up visits between 3 weeks and 3 months after completion of chemotherapy. Of 20 evaluable patients, 10% reported a need to wear a wig/head covering at the follow-up visit. Dean's alopecia score was excellent for 65% of patients, good for 25% of patients, and moderate or poor for 10% of patients. The majority of patients reported hair thinning after every chemotherapy cycle. No patient discontinued therapy because of an intolerance to cold caps. Scalp cooling with cold caps appears to be effective in preventing CIA among the majority of women undergoing treatment with TC chemotherapy. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. The 8th Japan Bioanalysis Forum symposium.

    Science.gov (United States)

    Matsumaru, Takehisa

    2017-11-01

    The 8th Japan Bioanalysis Forum symposium, the Tower Hall Funabori, Tokyo, Japan, 8-9 February 2017 The 8th Japan Bioanalysis Forum (JBF) symposium was successfully held between 8 and 9 February 2017 at the Tower Hall Funabori, Tokyo, Japan. In total, 24 speakers from Japan, USA and Europe gave presentations regarding the immunogenicity of biopharmaceuticals, ICH S3A Q&A microsampling, ICH M10 bioanalytical method validation, large molecule analysis through LC-MS, auditing activities for bioanalysis and biomarker bioanalysis. Achievements regarding eight diverse themes were also shared by Japan Bioanalysis Forum discussion groups. Over 300 scientists from regulatory agencies, industry and academia actively took part in discussions during the symposium. This article provides the highlights of all the topics discussed in this symposium.

  10. Implementation of the Additional Protocol in Japan

    International Nuclear Information System (INIS)

    Ogawa, T.

    2001-01-01

    The Additional Protocol between Japan and the IAEA entered into force in December 1999. To come into force a series of implementation trials of Additional Protocol was carried out at two Japanese representative nuclear research centers, i.e. Tokai Research Establishment of Japan Atomic Energy Research Institute (JAERI) and Oarai Engineering Center of Japan Nuclear Fuel Cycle Development Institute (JNC). These trials were proposed by Japan and were conducted in cooperation with the IAEA Secretariat. In addition, Japan amended 'the Law for the Regulation of Reactors etc.', to collect adequate information to submit to the IAEA, to arrange the surrounding for the complementary access, etc. In addition, Japan Submitted the Initial Declaration of the Additional Protocol within 180 days of the entry into force of the Protocol, in the middle of June, 2000

  11. WE-D-BRE-04: Modeling Optimal Concurrent Chemotherapy Schedules

    International Nuclear Information System (INIS)

    Jeong, J; Deasy, J O

    2014-01-01

    Purpose: Concurrent chemo-radiation therapy (CCRT) has become a more common cancer treatment option with a better tumor control rate for several tumor sites, including head and neck and lung cancer. In this work, possible optimal chemotherapy schedules were investigated by implementing chemotherapy cell-kill into a tumor response model of RT. Methods: The chemotherapy effect has been added into a published model (Jeong et al., PMB (2013) 58:4897), in which the tumor response to RT can be simulated with the effects of hypoxia and proliferation. Based on the two-compartment pharmacokinetic model, the temporal concentration of chemotherapy agent was estimated. Log cell-kill was assumed and the cell-kill constant was estimated from the observed increase in local control due to concurrent chemotherapy. For a simplified two cycle CCRT regime, several different starting times and intervals were simulated with conventional RT regime (2Gy/fx, 5fx/wk). The effectiveness of CCRT was evaluated in terms of reduction in radiation dose required for 50% of control to find the optimal chemotherapy schedule. Results: Assuming the typical slope of dose response curve (γ50=2), the observed 10% increase in local control rate was evaluated to be equivalent to an extra RT dose of about 4 Gy, from which the cell-kill rate of chemotherapy was derived to be about 0.35. Best response was obtained when chemotherapy was started at about 3 weeks after RT began. As the interval between two cycles decreases, the efficacy of chemotherapy increases with broader range of optimal starting times. Conclusion: The effect of chemotherapy has been implemented into the resource-conservation tumor response model to investigate CCRT. The results suggest that the concurrent chemotherapy might be more effective when delayed for about 3 weeks, due to lower tumor burden and a larger fraction of proliferating cells after reoxygenation

  12. Understanding Great Earthquakes in Japan's Kanto Region

    Science.gov (United States)

    Kobayashi, Reiji; Curewitz, Daniel

    2008-10-01

    Third International Workshop on the Kanto Asperity Project; Chiba, Japan, 16-19 February 2008; The 1703 (Genroku) and 1923 (Taisho) earthquakes in Japan's Kanto region (M 8.2 and M 7.9, respectively) caused severe damage in the Tokyo metropolitan area. These great earthquakes occurred along the Sagami Trough, where the Philippine Sea slab is subducting beneath Japan. Historical records, paleoseismological research, and geophysical/geodetic monitoring in the region indicate that such great earthquakes will repeat in the future.

  13. The Evolving Relations of Japan and India

    Science.gov (United States)

    2014-12-01

    Studies 28, no. 1 (May, 2008): 17, ProQuest (58773079). 2 K. V. Kesavan, India and Japan : Changing Dimensions of Partnership in the Post-Cold War Period ...inhibit sustained relations between Japan and India. A. FACTORS THAT CAN PROMOTE SUSTAINED RELATIONS After Commodore Perry arrived in Edo bay in... Japan : Changing Dimensions of Partnership in the Post-Cold War Period . Delhi, India: Observer Research Foundation, 2010. ProQuest (754079921

  14. Security of Japan and Korean Unification

    Science.gov (United States)

    2006-03-15

    isolation in both countries. The Tokugawa shogunate (1603-1868: Edo period ) had taken a national seclusion policy since 1639. Japan was threatened in the...invasion from peninsula, but the fear that Western powers might conquer the peninsula was realistic to some leaders at the end of the Edo period . Japan ... period (ca 10,000 BC-ca 300 BC), both prehistoric eras in the history of Japan . The basic elements of the culture of the Yayoi period , bronze and iron

  15. Discrimination against Women Workers in Japan

    OpenAIRE

    KARUBE, Keiko

    2017-01-01

    This paper discusses discrimination against women workers in Japan. Japan ratified the UNConvention on the Elimination of All Forms of Discrimination against Women in 1985. In April1986, the Equal Employment Opportunity Act (EEOA), a law which stipulates equal treatmentof women workers with men, became effective. The law was a major condition which enabled theJapanese government to ratify the UN Convention.More than thirty years have passed since then; however, women workers in Japan continue...

  16. Parental Income and Child Health in Japan

    OpenAIRE

    2012-01-01

    Previous studies have consistently found evidence of an income gradient in health among children in various countries, and studies in Anglo-Saxon countries have found that this gradient increases with child age. Using nationally representative individual-level data, I examine the association between child health and parental income in Japan. Japan has a child poverty rate that is similar to the rate of many countries that have been studied previously, but Japan outperforms those countries on ...

  17. Institutionalisation of Japan Identity Construction Policy

    Directory of Open Access Journals (Sweden)

    Zadvornaya Elena S.

    2016-09-01

    Full Text Available The article is devoted to the development of the modern politics of identity construction in Japan, which actively refers to the practice of designing self-image in international relations. This trend dates back to the 19th century, when there was the end of Sakoku (Japan’s policy of isolation. It is now possible to talk about the institutionalization of the identity construction policy to organized structures and regulations. Enhanced efforts in the field of Japanese traditional and popular culture, education and creative content has led to a number of institutions appearance (like Japan Foundation Fund, Japan Creative Agency, Japan Culture Fund, Agency for Cultural Affairs, Cool Japan Fund, Japan brand Fund and changing idea about the role of culture in foreign policy realization (it is fixed the documents of the Japanese Ministry of Foreign Affairs, the Ministry of Land, Infrastructure, Transport and Tourism, the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Economy, Trade and Industry, as well as a number of projects (Cool Japan, Visit Japan, Japan Culture Power, Japan Manga Awards, Kawaii Ambassadors, Cosplay International Fest and etc.. These efforts are aimed at forming Japan identity abroad to solve a number of foreign policy challenges of the future and the development of economic cooperation. The Japanese government nearest plans is to increase funding in order to create a positive image of Japan in the region of East Asia. All of these allows us to speak about the policy of the Japanese construction of identity as an institutionalized process in which there was clearance of organizations and regulatory activities.

  18. Bone marrow transplantation in Japan

    International Nuclear Information System (INIS)

    Masaoka, Tohru

    1989-01-01

    BMT in Japan was started in 1975. From 1981 Japan BMT study group was organized by the grant of ministry of health and welfare Japan. A rapid increase of number of BMT parallel to the improvement of results was observed in the 489 patients by the registry of this group. The major causes of failure of BMT were interstitial pneumonitis (IP), relapse of leukemia, infection, and graft versus host disease (GVHD). The incidence of IP decreased very rapidly by fractionation of total body irradiation and anti-cytomegalovirus (CMV) antibody negative platelet transfusion. Prophylactic administration of anti-CMV immunoglobulin produced also significant reduction of IP. In the double blind controled study oral administration of aciclovir revealed significant reduction of herpes stomatitis, followed by the reduction of other infections including sepsis. For the decontamination of bioclean room we have developed ozone decontamination, which revealed to be very effective for fungus. Colony stimulating factor was found to shorten the period of granulocytopenia. The patients with GVHD showed lower incidence of relapse of leukemia than those without GVHD. In the patients who received BMT during their first remission of ALL. Long survival rate was 63 %, for ANLL in the first remission, 64 % and for CML in the chronic phase, 40 %. Out of the first 20 BMT patients of the center for adult diseases Osaka, only three are living now, while out of the next 25 patients 22 are living disease free. Major items of modification of BMT procedures between those two groups were cyclosporine A, colony stimulating factor, fractionated TBI, CMV-negative platelet donar, BMT in first remission for acute leukemia or chronic phase in CML. BMT seemed to be a very reliable and promising treatment of leukemia with a very high possibility of complete cure. (author)

  19. Children in Japan and multimedia.

    Science.gov (United States)

    Shimauchi, Y

    1999-01-01

    Many parents in Japan today are very concerned and have daily problems with their children over the following kind of issues concerning video games, multimedia, and similar devices. 1) Is children's enthusiasm for video games actually harming their growth (physically or mentally)? 2) Is there any way that video games can help children in the future? For example, will playing these games help children learn to use computers or develop their power of thought? 3) Will excessive enthusiasm for TV games undermine our basic lifestyle? Is the time they spend studying at home or playing outside actually decreasing? 4) Will the methods of communication brought about by computers, pagers, and cellular phones weaken human relations among children? 5) Will being immersed in a virtual world created by computers result in a diminished sense of reality? The causes of this uneasiness may be traced to parents' own anxieties and concerns about the exceedingly rapid growth of the "information society" of today, together with the fact that their children are directly caught up in the deluge of this information and multimedia society. The development of media has coincided with the growth of today's adults, but children are immersed in a media-filled environment from the day they are born. In Japan, there are now children who can play video games before even learning to write. No one can predict what kind of adults these children will grow to be in the future, and it is fair to say that the most parents and children in Japan are being tossed about on the waves of this information explosion. At this international symposium, we hope to hear the many views that are held around the world concerning children and multimedia.

  20. Public information activities in Japan

    International Nuclear Information System (INIS)

    Ijima, Kazunori

    1998-01-01

    This is a slide presentation dealing with the public information (PI) activities in Japan. At present in Japan 51 nuclear power plants are in commercial operation contributing with a capacity of about 440 G We, i.e. 1/3 of the total electricity is produced by nuclear power. An investigation conducted by Advisory Committee for Energy resulted in the following guidelines in the advancing the Nuclear Power Policy: - maintain transparency in determining policy and reflect the voice of people, making information available to the public; - promote mutual understanding between areas that produce electricity by nuclear power and those that consume electricity; - cultivate an awareness of energy issues amongst the public to encourage them to take issues regarding Japan's energy policy to heart. Concerning the current PI, the following actions are undertaken at a nationwide scale: - for all people, supplying information by mass media, internet and holding lecture meetings and panel discussions etc; - for women, advertisements in journals; - for youth, educational materials, exhibition of energy etc; - for teachers, seminars; for opinion leaders, sending newsletters on nuclear energy. In areas for planned or constructed nuclear plants the PI actions are addressed to all people, women, fishermen, farmers and opinion leaders. There are given the responses to the following three questions addressed to the public concerning the nuclear power: - do you think whether we need nuclear power plants? - do you think whether nuclear power plants are safe? - what mechanism do you think generates energy during the production of nuclear power. A discussion of the results is presented. As future objectives of PI activities the following are in view: to cultivate reliability, to aware of information about nuclear power, to promote awareness of nuclear power, to promote mutual understanding of nuclear power. In conclusion, the need is stressed to make the PI activities more effective, to find

  1. Tsunami Scenario in the Nankai Trough, Japan, Based on the GPS-A and GNSS Velocities

    Science.gov (United States)

    Bock, Y.; Watanabe, S. I.; Melgar, D.; Tadokoro, K.

    2017-12-01

    We present two local tsunami scenarios for the Nankai trough, Japan, an area of significant seismic risk, using GPS-A and GNSS velocities and two different plate interface geometries to better assess the slip deficit rate. We expand on the work of Yokota et al. [2016, Nature] by: (1) Adding seafloor data collected by Nagoya University [Tadokoro et al., 2012 GRL] at the Kumano basin, (2) Aligning the geodetic data to the Nankai block (forearc sliver) to the tectonic model of Loveless and Meade [2010 JGR] - the earlier work ignored block boundaries such as the Median Tectonic Line (MTL) and may have overestimated the slip deficit rate, (3) Considering two different plate interface geometries - it is essential to use the accurate depth of the plate interface, especially for the offshore region where the faults are located near the observation sites, (4) Estimating and correcting for the postseismic displacements of the 2004 southeastern off the Kii Peninsula earthquakes (MJMA 7.1, 7.4). Based upon the refined model, we calculate the coseismic displacements and tsunami wave propagation assuming that a hundred years of constant slip deficit accumulation is released instantaneously. We used the open source software GeoClaw v5.3.1, which solves the two-dimensional shallow water equations with the finite volume technique [LeVeque, 2002 Cambridge University Press], for the local tsunami scenarios. We present the expected tsunami propagation models and wave profiles based on the geodetically-derived distribution of slip, stressing the importance of identifying fault locations and geometries. The location of the downdip edge of the coseismic rupture is essential to assess whether the coastal area would subside or not. The sensitivity to the plate interface geometries is increased in the near-trough region. From the point of view of disaster prevention, subsidence at the southern coast would heighten the tsunami runup distance (e.g., at gauges in Shimotsu and Irago). Further

  2. An evaluation of the permeability of chemotherapy gloves to three cancer chemotherapy drugs.

    Science.gov (United States)

    Singleton, L C; Connor, T H

    1999-10-01

    To evaluate the permeability of chemotherapy gloves when using carmustine (BCNU), etoposide, and paclitaxel, which were selected based on their reported toxicity and unique solvent systems. Thirteen brands of chemotherapy gloves and one brand of examination glove. Of the 14 glove types tested, 11 were made of latex, and 3 were made of nitrile. Ten samples of each type of glove were evaluated using rigorous laboratory test conditions usually not encountered in normal usage. The thickness of the gloves was measured using a digital caliper. The glove material was secured over glass vials containing the drug solution and inverted in plastic cell wells containing a filter paper disc. After a two-hour exposure time, the filter paper discs were removed and analyzed for the presence of the drug. Permeability (i.e., greater than or equal to 1% of the total amount of drug passing through the glove material.) All 14 types of gloves tested were impermeable to BCNU at two hours of exposure. Only two gloves, the Ansell Perry EP glove and the U.S. Clinical Chemo Bloc T glove, were impermeable to all three drugs. The remaining 12 gloves all demonstrated some level of permeation with etoposide at two hours, although 9 of the gloves had only 1 of 10 samples that were permeable. In all cases, percent of permeation was less than 2% of the amount of the drug in the test solution. Thirteen gloves tested for paclitaxel permeability were impermeable at the two-hour time period. The results of this study indicate that most of the chemotherapy gloves on the market are either impermeable or minimally permeable to these three chemotherapy drugs. Because gloves are universally recognized as a means of personal protection when handling cancer chemotherapy drugs, selection of a glove that is impermeable would be an obvious choice for healthcare workers. Although the present study was a static, laboratory-based study that did not duplicate actual work practice conditions. It should offer some

  3. Japan's technology and manufacturing infrastructure

    Science.gov (United States)

    Boulton, William R.; Meieran, Eugene S.; Tummala, Rao R.

    1995-01-01

    The JTEC panel found that, after four decades of development in electronics and manufacturing technologies, Japanese electronics companies are leaders in the development, support, and management of complex, low-cost packaging and assembly technologies used in the production of a broad range of consumer electronics products. The electronics industry's suppliers provide basic materials and equipment required for electronic packaging applications. Panelists concluded that some Japanese firms could be leading U.S. competitors by as much as a decade in these areas. Japan's technology and manufacturing infrastructure is an integral part of its microelectronics industry's success.

  4. Japan nuclear ship sea trial

    International Nuclear Information System (INIS)

    Yamazaki, Hiroshi; Kitamura, Toshikatus; Mizushima, Toshihiko

    1992-01-01

    The sea trial of the first Japan nuclear Ship 'MUTSU' was conducted from the end of October to December in 1990. The purpose of the sea trial was to verify the nuclear propulsive performances and maneuverabilities. The present report describes the results of the sea trial. These results are classified into four items: 1. Speed test and engineering performance tests 2. Maneuvering performance tests 3. Vibration tests 4. Other tests. Acceptable performances were demonstrated, as expected in the original design. The experience of the use of the Global Positioning System (GPS), which were newly adopted for the sea trial, is also reported. (author)

  5. Recent cryocooler progress in Japan

    Science.gov (United States)

    Matsubara, Y.

    1985-05-01

    The progress of cryocoolers and related devices in Japan is reviewed. The Japanese National Railways has developed the light weight 4 K on-board refrigerators since 1977 as part of the MAGLEV train program. Superconducting and cryogenic fundamental technology was examined which included high performance cryocooler, magnetic refrigerator and superfluid refrigeration. Space cryogenics such as the cooling systems of IR-detectors was studied. Cryocooler for special applications such as cryopump, NMR-CT and JJ devices was investigated. Compact heat exchangers, high performance regenerators and reliable compressors are investigated as a critical component technology.

  6. Teeth Filing in Ancient Japan

    OpenAIRE

    春成, 秀爾

    1989-01-01

    The custom of teeth filing consists in engraving two or three lines of grooves in human upper median incisors and one line of groove in the upper lateral incisor to work the teeth into forked form. This custom exsisted in Africa in 19th century, in the Central America from early Preclassic period (1400 B. C.) to Postclassic period (1500 A. D.) and in Japan in the latest Jomon period (1000-200 B. C.).Specimens of teeth filing in Jomon period have been unearthened from 8 sites in Aichi Prefectu...

  7. Japanese History, Post-Japan

    Directory of Open Access Journals (Sweden)

    George Lazopoulos

    2014-03-01

    Full Text Available Jason Ānanda Josephson, The Invention of Religion in Japan. Chicago, IL: University of Chicago Press, 2012. 408 pp. $90 (cloth, $30 (paper. Hwansoo Ilmee Kim, Empire of the Dharma: Korean and Japanese Buddhism, 1877–1912. Cambridge, MA: Harvard University Asia Center, 2012. 444 pp. $50 (cloth. Jung-Sun N. Han, An Imperial Path to Modernity: Yoshino Sakuzō and a New Liberal Order in East Asia, 1905–1937. Cambridge, MA: Harvard University Asia Center, 2012. 244 pp. $40 (cloth.

  8. Photovoltaic electricity production in Japan

    International Nuclear Information System (INIS)

    Destruel, P.

    2009-01-01

    The author first recalls the early investment of Japan in the solar energy which gave a leadership position to this country. However, it has been recently over-taken by Germany and Spain in terms of installed power. The share of the different technologies for the manufacturing of photovoltaic panels (polycrystalline silicon, mono-crystalline silicon, amorphous silicon, copper-indium-selenium cells) of different sizes, is presented, together with the current measures which are aimed at giving a new boost to this sector. The author tries then to foresee the evolutions of this sector during the next years and in a longer term (market prospective evolutions, factory projects, power station projects)

  9. Japan's technology and manufacturing infrastructure

    Science.gov (United States)

    Boulton, William R.; Meieran, Eugene S.; Tummala, Rao R.

    1995-02-01

    The JTEC panel found that, after four decades of development in electronics and manufacturing technologies, Japanese electronics companies are leaders in the development, support, and management of complex, low-cost packaging and assembly technologies used in the production of a broad range of consumer electronics products. The electronics industry's suppliers provide basic materials and equipment required for electronic packaging applications. Panelists concluded that some Japanese firms could be leading U.S. competitors by as much as a decade in these areas. Japan's technology and manufacturing infrastructure is an integral part of its microelectronics industry's success.

  10. Clinical and Experimental Projects on' Chemotherapy of Bladder ...

    African Journals Online (AJOL)

    1974-03-30

    Mar 30, 1974 ... In spite of the fact that chemotherapy of bladder tumours was attempted at the beginning of this century in the form of topical treatment with phenol and podophyllin, it can be said that modern chemotherapy started only after the discovery that nitrogen mustard was effective in the treatment of some human ...

  11. Is cytotoxic chemotherapy for lymphoma currently feasible for ...

    African Journals Online (AJOL)

    There is currently no systematic provision for chemotherapy of adult patients with cancer in Malawi. Is the introduction of such a service now feasible in Malawi, and should an individual patient with potentially treatable disease be given chemotherapy in the absence of such a service? The technical, economic and moral ...

  12. Rebound Thymic Hyperplasia after Chemotherapy in Children with Lymphoma

    Directory of Open Access Journals (Sweden)

    Chih-Ho Chen

    2017-04-01

    Conclusion: RTH developed in 67.7% of pediatric patients with lymphoma in CR after chemotherapy. The association of RTH development and lowered relapse rates has yet to be determined. Awareness of this phenomenon is important in the prevention of unnecessary surgical intervention or chemotherapy.

  13. Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia.

    LENUS (Irish Health Repository)

    Alazzam, Mo'iad

    2012-12-01

    Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. Various salvage regimens are used worldwide. It is unclear which regimens are the most effective and the least toxic.

  14. Adjuvant chemotherapy compliance is not superior after thoracoscopic lobectomy

    DEFF Research Database (Denmark)

    Licht, Peter B; Schytte, Tine; Jakobsen, Erik

    2014-01-01

    BACKGROUND: It is generally assumed that patient compliance with adjuvant chemotherapy is superior after video-assisted thoracoscopic surgery compared with open lobectomy for non-small cell lung cancer (NSCLC). The level of evidence for this assumption, however, is limited to single-institution, ......BACKGROUND: It is generally assumed that patient compliance with adjuvant chemotherapy is superior after video-assisted thoracoscopic surgery compared with open lobectomy for non-small cell lung cancer (NSCLC). The level of evidence for this assumption, however, is limited to single...... adjuvant chemotherapy and 121 (38.7%) completed all four cycles. Ordinal logistic regression revealed that chemotherapy compliance (none, partial, and full chemotherapy) was significantly reduced by the patient's age (p....02). No significant difference between video-assisted thoracoscopic surgery and thoracotomy was seen regarding chemotherapy compliance (p=0.17), number of chemotherapy cycles (p=0.60), or time from surgery to chemotherapy (p = 0.41). CONCLUSIONS: Complete national data do not support the widespread assumption...

  15. Durable control of metastatic nasopharyngeal carcinoma with metronomic chemotherapy

    Directory of Open Access Journals (Sweden)

    Po-Hsiang Huang

    2017-03-01

    Full Text Available Metronomic chemotherapy has shown encouraging efficacy and low toxicity in various tumor types and is one of the best treatment options for heavily pretreated patients or patients with advanced age and/or poor performance status. We demonstrated a patient with metastatic nasopharyngeal carcinoma who experienced durable disease control under etoposide-based combination metronomic chemotherapy.

  16. Coping strategies used by hospitalized children with cancer undergoing chemotherapy.

    Science.gov (United States)

    Sposito, Amanda Mota Pacciulio; Silva-Rodrigues, Fernanda Machado; Sparapani, Valéria de Cássia; Pfeifer, Luzia Iara; de Lima, Regina Aparecida Garcia; Nascimento, Lucila Castanheira

    2015-03-01

    To analyze coping strategies used by children with cancer undergoing chemotherapy during hospitalization. This was an exploratory study to analyze qualitative data using an inductive thematic analysis. Semistructured interviews using puppets were conducted with 10 children with cancer, between 7 and 12 years old, who were hospitalized and undergoing chemotherapy. The coping strategies to deal with chemotherapy were: understanding the need for chemotherapy; finding relief for the chemotherapy's side effects and pain; seeking pleasure in nourishment; engaging in entertaining activities and having fun; keeping the hope of cure alive; and finding support in religion. Children with cancer undergoing chemotherapy need to cope with hospitalizations, pain, medication side effects, idle time, and uncertainty regarding the success of treatment. These challenges motivated children to develop their own coping strategies, which were effective while undergoing chemotherapy. By gaining knowledge and further understanding about valid coping strategies during chemotherapy treatment, health professionals can mobilize personal and material resources from the children, health teams, and institutions aiming to potentiate the use of these strategies to make treatments the least traumatic. © 2015 Sigma Theta Tau International.

  17. Acute Abdominal Mobile Aortic Thrombus Post Chemotherapy: Two Cases Reports

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woo Chul; Kim, Jun Ho; Lee, Kyung Hee; Cho, Soon Gu; Jeon, Yong Sun [Dept. of Radiology, Inha University School of Medicine, Incheon (Korea, Republic of)

    2011-08-15

    An acute abdominal mobile aortic thrombus is a very unusual finding, and this is a potential source of arterial embolism. Mobile aortic thrombus mostly occurs in a diffuse atherosclerotic and aneurysmal aorta. Chemotherapy agents have been documented as a possible rare cause of acute arterial thrombus. We report acute abdominal mobile aortic thrombus post-chemotherapy for pancreatic and stomach cancer.

  18. Neoadjuvant chemotherapy and radiotherapy in locally advanced hypopharyngeal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Su Zy; Wu, Hong Gyun; Heo, Dae Seog; Park, Cham II [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2000-12-01

    To see the relationship between the response to chemotherapy and the final outcome of neoadjuvant chemotherapy and radiotherapy in patients with locally advanced hypopharyngeal cancer. A retrospective analysis was done for thirty-two patients with locally advanced hypopharyngeal cancer treated in the Seoul National University Hospital with neoadjuvant chemotherapy and radiotherapy from August 1979 to July 1997. The patients were treated with Co-60 teletherapy unit or 4MV or 6MV photon beam produced by linear accelerator. Daily fractionation was 1.75 to 2 Gy, delivered five times a week. Total dose ranged from 60.8 Gy to 73.8 Gy. Twenty-nine patients received continuous infusion of cisplatin and 5-FU. Other patients were treated with cisplatin combined with bleomycin or vinblastin. Twenty-four (75%) patients received all three prescribed cycles of chemotherapy delivered three weeks apart. Six patients received two cycles, and two patients received only one cycle. The overall 2-year and 5-year survival rates are 65.6% and 43.0, respectively. 5-year local control rate is 34%. Organ preservation for more than five years is achieved in 12 patients (38%). After neoadjuvant chemotherapy, 24 patients achieved more than partial remission (PR); the response rate was 75% (24/32). Five patients had complete remission (CR), 19 patients PR, and 8 patients no response (NR). Among the 19 patients who had PR to chemotherapy, 8 patients achieved CR after radiotherapy. Among the 8 non-responders to chemotherapy, 2 patients achieved CR, and 6 patients achieved PR after radiotherapy, There was no non-responder after radiotherapy. The overall survival rates were 60% for CR to chemotherapy group, 35.1 % for PR to chemotherapy group, and 50% for NR to chemotherapy group. respectively (p=0.93). There were significant difference in five-year overall survival rates between the patients with CR and PR after neoadjuvant chemotherapy and radiotherapy (73.3% vs. 14.7%, p< 0.01). The prognostic

  19. Chemotherapy for pulmonary large cell neuroendocrine carcinomas : Does the regimen matter?

    NARCIS (Netherlands)

    Derks, Jules L.; van Suylen, Robert Jan; Thunnissen, Erik; den Bakker, Michael A.; Groen, Harry J.; Smit, Egbert F.; Damhuis, Ronald A.; van den Broek, Esther C.; Speel, Ernst-Jan M.; Dingemans, Anne-Marie C.

    Pulmonary large cell neuroendocrine carcinoma (LCNEC) is rare. Chemotherapy for metastatic LCNEC ranges from small cell lung carcinoma (SCLC) regimens to nonsmall cell lung carcinoma (NSCLC) chemotherapy regimens. We analysed outcomes of chemotherapy treatments for LCNEC. The Netherlands Cancer

  20. A characteristic of polymorphic membrane protein F of Chlamydia trachomatis isolated from male urogenital tracts in Japan.

    Science.gov (United States)

    Yamazaki, Tomohiro; Matsuo, Junji; Takahashi, Satoshi; Kumagai, Shouta; Shimoda, Tomoko; Abe, Kiyotaka; Minami, Kunihiro; Yamaguchi, Hiroyuki

    2015-12-01

    Although sexually transmitted disease due to Chlamydia trachomatis occurs similarly in both men and women, the female urogenital tract differs from that of males anatomically and physiologically, possibly leading to specific polymorphisms of the bacterial surface molecules. In the present study, we therefore characterized polymorphic features in a high-definition phylogenetic marker, polymorphic outer membrane protein (Pmp) F of C. trachomatis strains isolated from male urogenital tracts in Japan (Category: Japan-males, n = 12), when compared with those isolated from female cervical ducts in Japan (Category: Japan-females, n = 11), female cervical ducts in the other country (Category: Ref-females, n = 12) or homosexual male rectums in the other country (Category: Ref-males, n = 7), by general bioinformatics analysis tool with MAFFT software. As a result, phylogenetic reconstruction of the PmpF amino acid sequences showing three distinct clusters revealed that the Japan-males were limited into cluster 1 and 2, although there were only four clusters even though including an outgroup. Meanwhile, the phylogenetic distance values of PmpF passenger domain without hinge region, but not its full-length sequence, showed that the Japan-males were more stable and displayed less diversity when compared with the other categories, supported by the sequence conservation features. Thus, PmpF passenger domain is a useful phylogenetic maker, and the phylogenic features indicate that C. trachomatis strains isolated from male urogenital tracts in Japan may be unique, suggesting an adaptation depending on selective pressure, such as the presence or absence of microbial flora, furthermore possibly connecting to sexual differentiation. Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  1. Sarcopenia and chemotherapy-mediated toxicity.

    Science.gov (United States)

    Vega, Maria Cecília Monteiro Dela; Laviano, Alessandro; Pimentel, Gustavo Duarte

    2016-01-01

    This narrative review focuses on the role of sarcopenia and chemotherapy-induced toxicity in cancer patients. Consistent evidence shows that sarcopenia in cancer patients leads to decreased overall survival by influencing treatment discontinuation and dose reduction. Therefore, sarcopenia should be considered a robust prognostic factor of negative outcome as well as a determinant of increased healthcare costs. RESUMO Esta revisão narrativa descreve o papel da sarcopenia e a toxicidade mediada pela quimioterapia em pacientes com câncer. Diversas evidências consistentes mostram que a sarcopenia em pacientes com câncer induz à menor sobrevida global, por influenciar na interrupção do tratamento e na redução da dose. Portanto, a sarcopenia pode ser considerada um importante fator de prognóstico de desfecho negativo, além de um determinante de maiores custos em saúde.

  2. Cancer chemotherapy: Challenges for the future

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Kiyoji (ed.) (National Nagoya Hospital (Japan)); Saito, H. (Nagoya Univ. (Japan)); Carter, S.K. (ed.) (Bristol-Myers Squibb Company, New York (United States)); Bast, R.C. Jr (ed.) (Duke Univ., Durham, NC (United States). Medical Center)

    1992-01-01

    At this symposium the main topics were new strategies for cancer therapy based on biology and pharmacology. Presentations on the biology of tumor progression and regression covered the molecular basis of cancer suppression by human tumor suppressor genes, mutation of the p53 gene and accumulation of the p53 protein, tumor suppressor genes involved in the pathogenesis of lung cancer, and lessons learned from studies on tumor suppression by chromosome transfer. Many new reports on oncogenes provided the highlights for these chemotherapists present. For cancer therapy based on pharmacology, papers were presented on drug resistance such as P-glycoprotein (p170) multidrug resistance (MDR) transporter limitations on successful therapy for childhood tumors: possible circumvention of MDR by cyclosporin A, regulation of the MDR gene in response to environmental stimuli, and dose-intensive chemotherapies. On the subject of cancer therapy, lung cancer was the focus of attention, and the efficacy of combined modalities was reported and discussed.

  3. Cancer chemotherapy: Challenges for the future

    International Nuclear Information System (INIS)

    Kimura, Kiyoji; Saito, H.; Carter, S.K.; Bast, R.C. Jr

    1992-01-01

    At this symposium the main topics were new strategies for cancer therapy based on biology and pharmacology. Presentations on the biology of tumor progression and regression covered the molecular basis of cancer suppression by human tumor suppressor genes, mutation of the p53 gene and accumulation of the p53 protein, tumor suppressor genes involved in the pathogenesis of lung cancer, and lessons learned from studies on tumor suppression by chromosome transfer. Many new reports on oncogenes provided the highlights for these chemotherapists present. For cancer therapy based on pharmacology, papers were presented on drug resistance such as P-glycoprotein (p170) multidrug resistance (MDR) transporter limitations on successful therapy for childhood tumors: possible circumvention of MDR by cyclosporin A, regulation of the MDR gene in response to environmental stimuli, and dose-intensive chemotherapies. On the subject of cancer therapy, lung cancer was the focus of attention, and the efficacy of combined modalities was reported and discussed

  4. Chronic Pain and Neuropathy Following Adjuvant Chemotherapy

    DEFF Research Database (Denmark)

    Ventzel, Lise; Madsen, Caspar S; Karlsson, Páll

    2017-01-01

    Objective: To determine symptoms and characteristics of chronic sensory neuropathy in patients treated with oxaliplatin and docetaxel, including patterns of somatosensory abnormalities, pain descriptors, and psychological functioning. Design: A retrospective cross-sectional study. Setting......: A chronic pain research center. Subjects: Thirty-eight patients with chronic peripheral pain and/or dysesthesia following chemotherapy. Methods:  Sensory profiles, psychological functioning, and quality of life were assessed using standardized questionnaires. In addition, standardized quantitative sensory...... with decreased mechanical and vibration detection thresholds. A high frequency of abnormalities in thermal sensory limen and the presence of paradoxical heat sensation seem to be sensitive markers of small fiber loss. Both groups had mainly sensory, axonal large fiber or mixed fiber polyneuropathy, which tended...

  5. Chemotherapy-Induced Neuropathy in Cancer Survivors.

    Science.gov (United States)

    Miaskowski, Christine; Mastick, Judy; Paul, Steven M; Topp, Kimberly; Smoot, Betty; Abrams, Gary; Chen, Lee-May; Kober, Kord M; Conley, Yvette P; Chesney, Margaret; Bolla, Kay; Mausisa, Grace; Mazor, Melissa; Wong, Melisa; Schumacher, Mark; Levine, Jon D

    2017-08-01

    Evidence suggests that chemotherapy-induced neuropathy (CIN) is a significant problem for cancer survivors. However, a detailed phenotypic characterization of CIN in cancer survivors is not available. To evaluate between-group differences in demographic and clinical characteristics, as well as in measures of sensation, function, and postural control, in a sample of cancer survivors who received a platinum and/or a taxane-based CTX regimen and did (n = 426) and did not (n = 197) develop CIN. Survivors completed self-report questionnaires and underwent objective testing (i.e., light touch, pain sensation, cold sensation, vibration, muscle strength, grip strength, Purdue Pegboard test, Timed Get Up and Go test, Fullerton Advanced Balance test). Parametric and nonparametric statistics were used to compare between-group differences in study outcomes. Of the 426 survivors with CIN, 4.9% had CIN only in their upper extremities, 27.0% only in their lower extremities, and 68.1% in both their upper and lower extremities. Demographic and clinical characteristics associated with CIN included the following: older age, lower annual income, higher body mass index, a higher level of comorbidity, being born prematurely, receipt of a higher cumulative dose of chemotherapy, and a poorer functional status. Survivors with CIN had worse outcomes for all of the following objective measures: light touch, pain, temperature, vibration, upper and lower extremity function, and balance. This study is the first to provide a detailed phenotypic characterization of CIN in cancer survivors who received a platinum and/or a taxane compound. These data can serve as a benchmark for future studies of CIN in cancer survivors. Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  6. Medical facility statistics in Japan.

    Science.gov (United States)

    Hamajima, Nobuyuki; Sugimoto, Takuya; Hasebe, Ryo; Myat Cho, Su; Khaing, Moe; Kariya, Tetsuyoshi; Mon Saw, Yu; Yamamoto, Eiko

    2017-11-01

    Medical facility statistics provide essential information to policymakers, administrators, academics, and practitioners in the field of health services. In Japan, the Health Statistics Office of the Director-General for Statistics and Information Policy at the Ministry of Health, Labour and Welfare is generating these statistics. Although the statistics are widely available in both Japanese and English, the methodology described in the technical reports are primarily in Japanese, and are not fully described in English. This article aimed to describe these processes for readers in the English-speaking world. The Health Statistics Office routinely conduct two surveys called the Hospital Report and the Survey of Medical Institutions. The subjects of the former are all the hospitals and clinics with long-term care beds in Japan. It comprises a Patient Questionnaire focusing on the numbers of inpatients, admissions, discharges, and outpatients in one month, and an Employee Questionnaire, which asks about the number of employees as of October 1. The Survey of Medical Institutions consists of the Dynamic Survey, which focuses on the opening and closing of facilities every month, and the Static Survey, which focuses on staff, facilities, and services as of October 1, as well as the number of inpatients as of September 30 and the total number of outpatients during September. All hospitals, clinics, and dental clinics are requested to submit the Static Survey questionnaire every three years. These surveys are useful tools for collecting essential information, as well as providing occasions to implicitly inform facilities of the movements of government policy.

  7. Isotope geochemists meet in Japan

    Science.gov (United States)

    Ito, E.; Harmon, R. S.; Elmore, D.; Nishiizumi, K.

    The Fifth International Conference on Geochronology, Cosmochronology, and Isotope Geology was held from June 27-July 2, 1982 in Nikko, Japan. These conferences are held every 4 years to review progress in geochronology and isotope geochemistry and to discuss results of the application of isotopic techniques to problems in the earth and space sciences. The first two, held in Canada in 1966 and Switzerland in 1970, were concerned with geochronology only. In 1974 the meeting in France expanded to include cosmochronology and stable isotopes. The subsequent 1978 meeting in the United States, and this year's meeting in Japan, followed that format. At the Nikko meeting the distribution of papers among the three general themes were: geochronology, 21%; cosmochronology, 23%; isotope geology, 56%, indicating a distinct trend toward the use of isotopes as tracers to solve geological and geochemical problems in both the earth and space sciences. The increasing tendency to consider coupled isotope-chemical systematics in such studies indicates that the next meeting, to be held in Cambridge, England in the summer of 1986, will probably formally integrate trace-element geochemistry.

  8. Transformer Efficiency Assessment - Okinawa, Japan

    Energy Technology Data Exchange (ETDEWEB)

    Thomas L. Baldwin; Robert J. Turk; Kurt S. Myers; Jake P. Gentle; Jason W. Bush

    2012-05-01

    The US Army Engineering & Support Center, Huntsville (USAESCH), and the US Marine Corps Base (MCB), Okinawa, Japan retained Idaho National Laboratory (INL) to conduct a Transformer Efficiency Assessment of “key” transformers located at multiple military bases in Okinawa, Japan. The purpose of this assessment is to support the Marine Corps Base, Okinawa in evaluating medium voltage distribution transformers for potential efficiency upgrades. The original scope of work included the MCB providing actual transformer nameplate data, manufacturer’s factory test sheets, electrical system data (kWh), demand data (kWd), power factor data, and electricity cost data. Unfortunately, the MCB’s actual data is not available and therefore making it necessary to de-scope the original assessment. Note: Any similar nameplate data, photos of similar transformer nameplates, and basic electrical details from one-line drawings (provided by MCB) are not a replacement for actual load loss test data. It is recommended that load measurements are performed on the high and low sides of transformers to better quantify actual load losses, demand data, and power factor data. We also recommend that actual data, when available, be inserted by MCB Okinawa where assumptions have been made and then the LCC analysis updated. This report covers a generalized assessment of modern U.S. transformers in a three level efficiency category, Low-Level efficiency, Medium-Level efficiency, and High-Level efficiency.

  9. Transformer Efficiency Assessment - Okinawa, Japan

    Energy Technology Data Exchange (ETDEWEB)

    Thomas L. Baldwin; Robert J. Turk; Kurt S. Myers; Jake P. Gentle; Jason W. Bush

    2012-08-01

    The US Army Engineering & Support Center, Huntsville (USAESCH), and the US Marine Corps Base (MCB), Okinawa, Japan retained Idaho National Laboratory (INL) to conduct a Transformer Efficiency Assessment of “key” transformers located at multiple military bases in Okinawa, Japan. The purpose of this assessment is to support the Marine Corps Base, Okinawa in evaluating medium voltage distribution transformers for potential efficiency upgrades. The original scope of work included the MCB providing actual transformer nameplate data, manufacturer’s factory test sheets, electrical system data (kWh), demand data (kWd), power factor data, and electricity cost data. Unfortunately, the MCB’s actual data is not available and therefore making it necessary to de-scope the original assessment. Note: Any similar nameplate data, photos of similar transformer nameplates, and basic electrical details from one-line drawings (provided by MCB) are not a replacement for actual load loss test data. It is recommended that load measurements are performed on the high and low sides of transformers to better quantify actual load losses, demand data, and power factor data. We also recommend that actual data, when available, be inserted by MCB Okinawa where assumptions have been made and then the LCC analysis updated. This report covers a generalized assessment of modern U.S. transformers in a three level efficiency category, Low-Level efficiency, Medium-Level efficiency, and High-Level efficiency.

  10. Solar Public Observations in Japan

    Science.gov (United States)

    Yaji, K.

    2002-01-01

    Now in Japan, there are more than fifty astronomical educational facilities which have solar telescopes, for example, public observatories and science museums. Because many of the solar telescopes have H-alpha filters, such active chromospheric phenomena as solar flares and prominences are easily presented to the public. Though the objects of these solar telescopes must be mainly education and public outreach, they have enough good performance to contribute to solar research. But, the staff in the most of facilities don't know well how to observe the sun and how to understand the solar phenomena. So, we started two attempts in order to support their solar observations. One is the administration of the "Solar Telescope Mailing List (solnet ML)". The purpose is exchanges of information on solar daily phenomena, instruments of solar telescopes, and solar articles. Almost one hundred solar observers use actively this mailing list. The other is the arrangement of the "Solar Telescope Workshop", which were held in 2000 and 2001. These workshops provide a chance for staff in public observational facilities to study observational methods, to learn educational techniques using solar observations, and to show their observational results on solar active phenomena. These two attempts also play a role to link public observers with professional solar researchers. In this presentation, we review the current situation of public solar observations in Japan and introduce solar images observed with the public educational facilities. In addition, we would like to mention what we hope for professional solar researchers.

  11. Laser precision microfabrication in Japan

    Science.gov (United States)

    Miyamoto, Isamu; Ooie, Toshihiko; Takeno, Shozui

    2000-11-01

    Electronic devices such as handy phones and micro computers have been rapidly expanding their market recent years due to their enhanced performance, down sizing and cost down. This has been realized by the innovation in the precision micro- fabrication technology of semiconductors and printed wiring circuit boards (PWB) where laser technologies such as lithography, drilling, trimming, welding and soldering play an important role. In phot lithography, for instance, KrF excimer lasers having a resolution of 0.18 micrometers has been used in production instead of mercury lamp. Laser drilling of PWB has been increased up to over 1000 holes per second, and approximately 800 laser drilling systems of PWB are expected to be delivered in the world market this year, and most of these laser processing systems are manufactured in Japan. Trend of laser micro-fabrication in Japanese industry is described along with recent topics of R&D, government supported project and future tasks of industrial laser precision micro-fabrication on the basis of the survey conducted by Japan laser Processing Society.

  12. Nuclear power development in Japan

    International Nuclear Information System (INIS)

    Mishiro, M.

    2000-01-01

    This article describes the advantages of nuclear energy for Japan. In 1997 the composition of the total primary energy supply (TPES) was oil 52.7%, coal 16.5%, nuclear 16.1% and natural gas 10.7%. Nuclear power has a significant role to play in contributing to 3 national interests: i) energy security, ii) economic growth and iii) environmental protection. Energy security is assured because a stable supply of uranium fuel can be reasonably expected in spite of dependence on import from abroad. Economic growth implies the reduction of energy costs. As nuclear power is capital intensive, the power generation cost is less affected by the fuel cost, therefore nuclear power can realize low cost by favoring high capacity utilization factor. Fossil fuels have substantial impacts on environment such as global warming and acid rain by releasing massive quantities of CO 2 , so nuclear power is a major option for meeting the Kyoto limitations. In Japan, in 2010 nuclear power is expected to reach 17% of TPES and 45% of electricity generated. (A.C.)

  13. Great East Japan Earthquake Tsunami

    Science.gov (United States)

    Iijima, Y.; Minoura, K.; Hirano, S.; Yamada, T.

    2011-12-01

    The 11 March 2011, Mw 9.0 Great East Japan Earthquake, already among the most destructive earthquakes in modern history, emanated from a fault rupture that extended an estimated 500 km along the Pacific coast of Honshu. This earthquake is the fourth among five of the strongest temblors since AD 1900 and the largest in Japan since modern instrumental recordings began 130 years ago. The earthquake triggered a huge tsunami, which invaded the seaside areas of the Pacific coast of East Japan, causing devastating damages on the coast. Artificial structures were destroyed and planted forests were thoroughly eroded. Inrush of turbulent flows washed backshore areas and dunes. Coastal materials including beach sand were transported onto inland areas by going-up currents. Just after the occurrence of the tsunami, we started field investigation of measuring thickness and distribution of sediment layers by the tsunami and the inundation depth of water in Sendai plain. Ripple marks showing direction of sediment transport were the important object of observation. We used a soil auger for collecting sediments in the field, and sediment samples were submitted for analyzing grain size and interstitial water chemistry. Satellite images and aerial photographs are very useful for estimating the hydrogeological effects of tsunami inundation. We checked the correspondence of micro-topography, vegetation and sediment covering between before and after the tsunami. The most conspicuous phenomenon is the damage of pine forests planted in the purpose of preventing sand shifting. About ninety-five percent of vegetation coverage was lost during the period of rapid currents changed from first wave. The landward slopes of seawalls were mostly damaged and destroyed. Some aerial photographs leave detailed records of wave destruction just behind seawalls, which shows the occurrence of supercritical flows. The large-scale erosion of backshore behind seawalls is interpreted to have been caused by

  14. An Experiment on GPS/A Seafloor Positioning in the Central Part of Kumano-nada, Central Japan

    Science.gov (United States)

    Fujimoto, H.; Sweeney, A.; Miura, S.; Kido, M.; Osada, Y.

    2004-12-01

    Kumano-nada, northeast of Kii Peninsula in the central part of Japan, is a seismogenic zone of the M-8 class Tonankai earthquakes that occurred repeatedly at an interval of about 100 years. The MEXT (Ministry of Education, Culture, Sports, Science and Technology, Japan) initiated a 5-year program in 2003 for seafloor observations in and around Kumano-nada. Nagoya and Tohoku Universities initiated experiments on GPS/A seafloor positioning to monitor crustal deformation in the subduction zone with a focus on investigation of the effect of sound velocity structure in the ocean on seafloor positioning (e.g., Tadokoro et al., this meeting). Tohoku group deployed five precision acoustic transponders (PXPs) jointly developed with Scripps Institution of Oceanography in the central part of Kumano-nada at depths of about 2,000m. The deployed PXPs A, B, C, and D form a diamond on the seafloor, and PXPs C, D, and E form a triangle. Although three typhoons were in the way of our 12-day cruise in August this year, we carried out GPS/A observation for several days. After an observation for locating the precise position of each PXP, we tried to keep the buoy near the center of the diamond or the triangle. The vessel held the position within 20-30m from the center, and the buoy_fs position was kept with 100m from the center. Kinematic GPS positioning is now under processing with GEONET data observed in Kii Peninsula. We also tried monitoring the sound velocity structure with 3 sets of inverted echo sounders (IESs) deployed near the PXPs C, D, and E. The IESs can monitor temporal and spatial variation in the sound velocity structure in the triangle array of PXPs. We plan to carry out the second GPS/A observation in November. The result is worthy of notice. Strange earthquakes of magnitude 6.9, 7.4, and 6.4 occurred on the nearest Nankai Trough axis on September 5-7, 2004. Co-seismic crustal deformation observed by the GEONET was about 4 cm near the coast of Kii Peninsula. The

  15. Thalidomide for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy

    Directory of Open Access Journals (Sweden)

    Geng Song

    2017-03-01

    Full Text Available Background Antiemetic guidelines recommend co-administration of agents to maximize the prevention of chemotherapyinduced nausea and vomiting (CINV, however, the control of delayed CINV is still not satisfactory. The purpose of this study was to evaluate the effectiveness and safety of thalidomide in the prevention of CINV. Methods Of 89 patients enrolled, 83 chemotherapy-naïve patients receiving highly emetogenic chemotherapy (cisplatin 70mg/m2 were randomized into two groups: standard therapy group (ondansetron on day 1, metoclopramide and dexamethasone on days one to five and thalidomide group (in addition to standard emesis prevention, patients received oral 100mg thalidomide on days one to five. Patients recorded nausea and vomiting episodes in a diary. The primary end point was the efficacy of thalidomide in controlling vomiting and nausea on days one to five post cisplatin, and the secondary end point was the safety of the thalidomide. Results No significant differences of complete response rates (no emesis, no use of rescue therapy and no nausea were observed between the two groups, while the percentages of patients with complete response of delayed vomiting on day four and day five were higher in the thalidomide group, furthermore, the complete response rate of delayed nausea for thalidomide group and standard therapy group showed significant differences. Thalidomide group showed a similar safety profile as standard emesis prevention group. Conclusion Addition of thalidomide was generally well tolerated and improved prevention of CINV in patients receiving cisplatinbased chemotherapy to some degree, especially for delayed nausea.

  16. ESA joins forces with Japan on new infrared sky surveyor

    Science.gov (United States)

    2006-02-01

    launch of ESA’s Herschel infrared mission, in early 2008,” commented Prof. Southwood. With the largest and most powerful space telescope to date (3.5 metres in diameter), Herschel will build on the ASTRO-F census of the infrared universe and on the legacy left by other satellites such as ESA’s ISO and NASA’s Spitzer. It will reveal the deepest secrets of galaxies and of star formation and evolution, while also studying the chemistry of the cold, hidden cosmos. Note for editors ASTRO-F is the result of a truly international effort. It was developed by the Japan Aerospace Exploration Agency (ISAS/JAXA), with the participation of Nagoya University, the University of Tokyo, the National Institute of Information & Communications Technology and other Japanese universities and institutes. Including South Korea, the project also draws on the involvement of ESA and a consortium of UK universities (Imperial College, London, the Open University, the University of Sussex) funded by the Particle Physics and Astronomy Research Council (PPARC), as well as the Netherlands Institute for Space Research and Groningen University (NL). ESA’s ground-station support will be managed by the European Space Operations Centre (ESOC). ESA’s European Space Astronomy Centre (ESAC) is in charge of pointing reconstruction and user support for European open time observations. ASTRO-F is carrying onboard a cooled telescope with an approx. 70 centimetre aperture. It is also equipped with two instruments: the Far-Infrared Surveyor (FIS) and the Infrared Camera (IRC). Together, they will make possible an all-sky survey in six infrared wavelengths. These instruments will also perform detailed photometric and spectroscopic observation of selected astronomical targets over the 2-180 micrometre wavelength range in 13 bands. During the survey, ASTRO-F will provide a complete infrared map of our galaxy with its stellar nurseries, which are only observable in infrared because their visible light is

  17. Internet Ethics Issues and Actions in Japan

    OpenAIRE

    江澤, 義典

    2013-01-01

    The International Symposium on Internet Ethics 2012 was planned and organized by the Korea Internet Security Agency and was held in September 2012 at the Lotte Hotel World in Seoul. This note relates to the presentation in Japan, it outlines current Internet ethics issues and actions in Japan. Moreover, four aspects of Japanese civilization were introduced as the bases of these ethics issues.

  18. On recycling of nuclear fuel in Japan

    Energy Technology Data Exchange (ETDEWEB)

    1992-04-01

    In Japan, atomic energy has become to accomplish the important role in energy supply. Recently the interest in the protection of global environment heightened, and the anxiety on oil supply has been felt due to the circumstances in Mideast. Therefore, the importance of atomic energy as an energy source for hereafter increased, and the future plan of nuclear fuel recycling in Japan must be promoted on such viewpoint. At present in Japan, the construction of nuclear fuel cycle facilities is in progress in Rokkasho, Aomori Prefecture. The prototype FBR 'Monju' started the general functional test in May, this year. The transport of the plutonium reprocessed in U.K. and France to Japan will be carried out in near future. This report presents the concrete measures of nuclear fuel recycling in Japan from the long term viewpoint up to 2010. The necessity and meaning of nuclear fuel recycling in Japan, the effort related to nuclear nonproliferation, the plan of nuclear fuel recycling for hereafter in Japan, the organization of MOX fuel fabrication in Japan and abroad, the method of utilizing recovered uranium and the reprocessing of spent MOX fuel are described. (K.I.).

  19. Unconscious Provocations - America and Japan Before 1941

    Science.gov (United States)

    2012-03-20

    xenophobia , failed diplomacy and deterrence, followed by attempts to contain Japan exacerbated Japanese isolation, nationalism, and desperation, and...beginning of World War I, Japan and the United States deeply mistrusted each other. Xenophobia perpetuated by irresponsible journalism and openly hostile...international status as an economic superpower. Xenophobia in China is alive and nationalism is rising. Some conservative, usually older, Chinese are

  20. The Role of German in Japan.

    Science.gov (United States)

    Sang, Juergen

    This historical overview of German studies in Japan, dating from the birth of modern Japan in the 1870's to the present time, includes commentary on the nature and scope of existing language programs. The importance of German idealism--reflected in the philosophy of Kant, Hegel, Schopenhauer, Nietzsche, and Marx--on Japanese culture is noted.…

  1. Testing the Nuclear Will of Japan

    Science.gov (United States)

    2007-12-01

    157 “Japan’s Nuclear Fuel Cycle Facilities,” Japan’s Nuclear Power Program: Power for the Future of Japan, http://www.japannuclear.com/ nuclearpower ...of Japan, http://www.japannuclear.com/ nuclearpower /fuelcycle/facilities.html. “Japan’s Parliament Elects Fukuda Prime Minister,” The China Daily

  2. Japan mellem øst og vest

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted; Ipsen, Lene

    Skildrer Japans historie gennem de sidste 200 år inklusiv et kapitel om historiebrug ift. Nanjingmassakren i 1937-1938.......Skildrer Japans historie gennem de sidste 200 år inklusiv et kapitel om historiebrug ift. Nanjingmassakren i 1937-1938....

  3. Rethinking Perspectives on Educational "Exchanges" with Japan.

    Science.gov (United States)

    Heginbotham, Stanley J.

    1997-01-01

    Argues that the fact that there are more Japanese students studying in the United States than there are U.S. students in Japan is not a problem in itself, but that the United States should develop and sustain its expertise on Japan. Educators and exchange specialists should cooperate to expand academic, work-study, and internship programs in…

  4. Japan: Language Policy and Planning in Transition

    Science.gov (United States)

    Gottlieb, Nanette

    2008-01-01

    This monograph discusses the language situation in Japan, with an emphasis on language planning and policy. Japan has long considered itself to be a monoethnic and therefore monolingual society, despite the existence of substantial old-comer ethnic minorities, and this--with the instrumental exception of English--has been reflected in its language…

  5. Japan's yen contribution to UNFPA unchanged.

    Science.gov (United States)

    1998-02-01

    As a result of the Japanese government's cabinet decision to cut Japan's total official development assistance (ODA) budget by 10%, the UNFPA expected to receive less financial support from Japan for 1998. In 1997, Japan provided 18% of UNFPA's budget. However, despite the government's announcement that the 10% cut would be applied across the board without exception, the Japanese government announced on December 24 that its yen contribution to UNFPA in 1998 will stay at its 1997 level. This decision was announced following top-level negotiations with the prime minister involving the Ministry of Foreign Affairs (MOFA) and the Ministry of Finance, and reflects the success of a major advocacy effort both inside and outside of Japan. In yen, the budgets of neither the UNFPA, UNICEF, nor UNHCR were reduced. However, in real terms, Japan will contribute fewer US dollars to UNFPA due to the depreciation of the yen.

  6. Quality Function Deployment: Application to Chemotherapy Unit Services

    Directory of Open Access Journals (Sweden)

    Neda Hashemi

    2015-10-01

    Full Text Available Background: Today’s healthcare organizations are challenged by pressures to meet growing population demands and enhance community health through improving service quality. Quality function deployment is one of the widely-used customerdriven approaches for health services development. In the current study, quality function deployment is used to improve the quality of chemotherapy unit services. Methods: First, we identified chemotherapy outpatient unit patients as chemotherapy unit customers. Then, the Delphi technique and component factor analysis with orthogonal rotation was employed to determine their expectations. Thereafter, data envelopment analysis was performed to specify user priorities. We determined the relationships between patients’ expectations and service elements through expert group consensus using the Delphi method and the relationships between service elements by Pearson correlation. Finally, simple and compound priorities of the service elements were derived by matrix calculation. Results: Chemotherapy unit patients had four main expectations: access, suitable hotel services, satisfactory and effective relationships, and clinical services. The chemotherapy unit has six key service elements of equipment, materials, human resources, physical space, basic facilities, and communication and training. There were four-level relationships between the patients’ expectations and service elements, with mostly significant correlations between service elements. According to the findings, the functional group of basic facilities was the most critical factor, followed by materials. Conclusion: The findings of the current study can be a general guideline as well as a scientific, structured framework for chemotherapy unit decision makers in order to improve chemotherapy unit services.

  7. Pre-Irradiation Chemotherapy in High Risk Medulloblastoma

    International Nuclear Information System (INIS)

    Abd-El-Aal, H.

    2006-01-01

    Rationale: The present study evaluates the effect of pre-irradiation chemotherapy in pediatric patients with high risk medulloblastoma. Twenty-four (24) pediatric patients attended the pediatric unit of Kasr-EI-Aini Center of Radiation Oncology and Nuclear Medicine (NEMROCK) from January 2000 to January 2003. Patients and Methods: Our patients were 13 boys and II girls aged 3-12 years with a median of 6.5 years. According to Chang staging system 6 cases had T2, 14 cases had T3 A and 4 cases had T3 B, 20 cases were M0, 3 cases were M I and I case was M2. All patients were treated by initial surgery, 2 cycles of pre-irradiation chemotherapy followed by craniospinal radiation then by 4 cycles of post-radiation chemotherapy. Results: Fifteen out of the 20 patients with M0 had objective response (10CR + 5PR) and no one had disease progression after pre-irradiation chemotherapy. Among 4 patients with M0 disease, 2 patients had PR and 2 had S.D. There was no disease progression among patients who received pre-irradiation chemotherapy. The 3-year overall survival and 3-year progression-free survival; (PFS) were 50% and 51 %, respectively, Myelosuppression was the main toxic effect observed during pre-irradiation chemotherapy; however, there was no delay or interruption of craniospinal irradiation. Conclusion: Pre-irradiation chemotherapy is effective in high risk medulloblastoma and is associated with acceptable side effects. The delay in craniospinal irradiation (CSI) for about 5 weeks to receive 2 courses of chemotherapy will not significantly increase disease progression. Multiple cycles of post-irradiation chemotherapy can be given safely after C51. A larger number of patients and longer follow-up is needed to confirm the results

  8. The gas industry in Japan

    International Nuclear Information System (INIS)

    Jego, H.

    2000-01-01

    Though oil is the most widely used primary energy in Japan, its market share is decreasing steadily in favour of other energies such as natural gas. Around 80 % of the gas consumed in Japan is imported in the form of LNG, with locally produced natural gas accounting for 5 % and LPG 12%. Annual LNG supplies now total 48 million tons (720 TWh) and are forecast to rise to 57 million tons over the next ten years. However, only on third of the total volume of LNG, i.e., 242 TWh, is distributed to final consumers. The rest is imported directly by power companies to produce electricity. The 245 gas distribution companies, 70 in the public sector and 175 in the private sector (including three large firms: Tokyo Gas, Osaka Gas and Toho Gas) carry the gas through their own non-interconnected networks to around 25 million customers, though the gas supply area covers only 5 % of the country. This small percentage can be explained partly by Japan's topography: 80 % of the land is covered by mountains. This means that only 20 % of the country is suitable for industrial and residential development. Populations living outside the gas supply areas mainly use LPG. The number of LPG customers totals around 25 million, a similar number to those using mains gas. However, the share of mains gas is increasing each year due to the population increase in urban zones. Though gas represents only 11 % of the energy consumed in Japan, it is nevertheless present on practically all markets and holds the leading position for domestic hot water and cooking in the residential sector. However, for heating, it lags well behind oil. In industry, mains gas covers only 5% of energy needs. However, with the expansion of the pipeline network and market liberalization, the share of gas is set to increase. The price of gas for the residential sector is 2 to 3 times higher than in western countries. This can be attributed to the following factors: most natural gas is imported LNG; unit consumption in the

  9. National Astronomical Observatory of Japan

    CERN Document Server

    Haubold, Hans J; UN/ESA/NASA Workshop on the International Heliophysical Year 2007 and Basic Space Science, hosted by the National Astronomical Observatory of Japan

    2010-01-01

    This book represents Volume II of the Proceedings of the UN/ESA/NASA Workshop on the International Heliophysical Year 2007 and Basic Space Science, hosted by the National Astronomical Observatory of Japan, Tokyo, 18 - 22 June, 2007. It covers two programme topics explored in this and past workshops of this nature: (i) non-extensive statistical mechanics as applicable to astrophysics, addressing q-distribution, fractional reaction and diffusion, and the reaction coefficient, as well as the Mittag-Leffler function and (ii) the TRIPOD concept, developed for astronomical telescope facilities. The companion publication, Volume I of the proceedings of this workshop, is a special issue in the journal Earth, Moon, and Planets, Volume 104, Numbers 1-4, April 2009.

  10. Japan between tradition and renewal

    DEFF Research Database (Denmark)

    Greve, Anni

    "The film “Beyond Metabolism” portrays the International Congress Centre in Kyoto, built in 1966 by Sachio Otani. It became known as the setting for the signing of the ‘Kyoto Protocol’. The film captures the atmosphere of the building and thereby raises the question of what impact the Metabolist ....... What is the status and function of tradition in today’s Japanese society? How does it manifest in architecture and urban life? And what specific role does it play in the differences between rural and urban architecture?"...... architecture had on the outcome of the congress. In conversation with Viktoria Diemer Bennetzen, the sociologist Professor Anni Greve will take a closer look ‘beyond metabolism’ - the last architectural avantgarde from Japan. They will examine the transition from Metabolism to contemporary architecture and ask...

  11. Application of EB in Japan

    International Nuclear Information System (INIS)

    Sunaga, Hiromi

    2003-01-01

    Radiation processing using electron beam (EB) facilities other than gamma-ray facilities in Japan is introduced. After briefly presented the features of EB compared with gamma ray, present status of EB application is described. Polymerized materials for use of wire, cable, radial tire, heat shrinkable tube, foam polyethylene, PTFE, battery separator, and adsorbent material are known to be resulting from cross-linking, decomposition, and graft polymerization reactions. Environmental preservation includes electron flue gas treatment in the coal- or oil-fired power plants, research for volatile organic compounds (VOC) and dioxins, as well as wastewater and sludge treatment. Finally activity of JAERI in the related fields is overviewed with the authors prospects for utilization of low energy EB with low cost for surface treatment and functional materials. (S. Ohno)

  12. Process of care and preliminary outcome in limited-stage small-cell lung cancer: results of the 1995-1997 patterns of care study in Japan

    International Nuclear Information System (INIS)

    Uno, Takashi; Sumi, Minako; Sawa, Yoshihide M.S.; Teshima, Teruki; Hara, Ryusuke; Ikeda, Hiroshi; Inoue, Toshihiko

    2003-01-01

    Purpose: To evaluate the practice process using the national average (Na); to compare differences in the process of care by age group; and to provide a preliminary outcome data for limited-stage small-cell lung cancer in Japan. Methods and Materials: The Patterns of Care Study conducted a nationwide survey of the care process for Stage I-III small-cell lung cancer in Japan. Patients were divided into three age groups: <65 years (younger group, n = 73); between 65 and 74 years (intermediate group, n = 81); and ≥75 years (elderly group, n = 20). Results: The NA for the total dose was 49.0 Gy, and for use of photon energy ≥6 MV, chemotherapy, and prophylactic cranial irradiation was 77.3%, 93.2%, and 1.69%, respectively. Age stratification had no impact on the variables of radiotherapy (RT) such as total dose and field size. Only 37% of patients received chemotherapy and thoracic RT concurrently. The proportion of patients who received chemotherapy and RT concurrently was 44%, 27%, and 25% of the younger, intermediate, and elderly groups, respectively (p = 0.029). Etoposide and cisplatin were less frequently used in the elderly group (≥75 years old). Overall survival at 3 years for the entire group was 26%. The 3-year survival rate was 30% in the younger group, 28% in the intermediate group, and 9% in the elderly group. Variables found to have a significant impact on survival by multivariate analysis were the use of chemotherapy (p = 0.030), age (p 0.032), and T stage (p = 0.042). Conclusion: Calculated NAs showed that the results of clinical study had favorably penetrated into the practice process in Japan. The results demonstrated that patient age significantly influenced the process of chemotherapy such as the use of etoposide and cisplatin for limited-stage small-cell lung cancer in Japan. More concurrent chemotherapy and thoracic RT and the application of prophylactic cranial irradiation for complete responders need to be investigated in the future

  13. Chemotherapy-induced peripheral neuropathy: a literature review

    Directory of Open Access Journals (Sweden)

    Lelia Gonçalves Rocha Martin

    2011-12-01

    Full Text Available Peripheral neuropathy is a common side effect in patients undergoing cancer treatment with chemotherapy. This condition can affect patients in several different ways, interfering in their activities of daily living and autonomy. The present study aimed to review the literature on chemotherapy-induced peripheral neuropathy and its treatment or other possible interventions. The findings reveal that chemotherapy-induced peripheral neuropathy is a common condition that affects patients undergoing treatment with some specific drugs. Besides, several different substances have been used to treat or control this condition, although no significant evidence could be found in these studies.

  14. Update on Intra-Arterial Chemotherapy for Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Mario Zanaty

    2014-01-01

    Full Text Available The tools for managing retinoblastoma have been increasing in the past decade. While globe-salvage still relies heavily on intravenous chemotherapy, tumors in advanced stage that failed chemotherapy are now referred for intra-arterial chemotherapy (IAC to avoid enucleation. However, IAC still has many obstacles to overcome. We present an update on the indications, complications, limitations, success, and technical aspects of IAC. Given its safety and high efficacy, it is expected that IAC will replace conventional strategies and will become a first-line option even for tumors that are amenable for other strategies.

  15. Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study

    Directory of Open Access Journals (Sweden)

    Kitahata R

    2017-10-01

    Full Text Available Ryosuke Kitahata,1 Shinichiro Nakajima,1–4 Hiroyuki Uchida,1,3 Tetsu Hayashida,5 Maiko Takahashi,5 Shintaro Nio,1 Jinichi Hirano,1 Maki Nagaoka,1 Takefumi Suzuki,1 Hiromitsu Jinno,6 Yuko Kitagawa,5 Masaru Mimura1 1Psychopharmacology Research Program, Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan; 2Multimodal Imaging Group – Research Imaging Centre, 3Geriatric Mental Health Division, Centre for Addiction and Mental Health, 4Department of Psychiatry, University of Toronto, Toronto, Canada; 5Department of Surgery, School of Medicine, Keio University, 6Department of Surgery, School of Medicine, Teikyo University, Tokyo, Japan Purpose: The purpose of the study was to evaluate subjective (self-rated, family-rated, and objective (researcher-rated cognitive functions in patients with breast cancer after chemotherapy.Method: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0 and 6 months later (T1. Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ, Dysexecutive Questionnaire (DEX-S, and Everyday Memory Checklist (EMC-S for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions.Results: At T0, 6 (20.0% and 2 (6.7% participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0% and 2 (100.0% participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective

  16. Medical visits for chemotherapy and chemotherapy-induced neutropenia: a survey of the impact on patient time and activities

    Directory of Open Access Journals (Sweden)

    Moore Kelley

    2004-05-01

    Full Text Available Abstract Background Patients with cancer must make frequent visits to the clinic not only for chemotherapy but also for the management of treatment-related adverse effects. Neutropenia, the most common dose-limiting toxicity of myelosuppressive chemotherapy, has substantial clinical and economic consequences. Colony-stimulating factors such as filgrastim and pegfilgrastim can reduce the incidence of neutropenia, but the clinic visits for these treatments can disrupt patients' routines and activities. Methods We surveyed patients to assess how clinic visits for treatment with chemotherapy and the management of neutropenia affect their time and activities. Results The mean amounts of time affected by these visits ranged from approximately 109 hours (hospitalization for neutropenia and 8 hours (physician and chemotherapy to less than 3 hours (laboratory and treatment with filgrastim or pegfilgrastim. The visits for filgrastim or pegfilgrastim were comparable in length, but treatment with filgrastim requires several visits per chemotherapy cycle and treatment with pegfilgrastim requires only 1 visit. Conclusions This study provides useful information for future modelling of additional factors such as disease status and chemotherapy schedule and provides information that should be considered in managing chemotherapy-induced neutropenia.

  17. Japan's National Security: Structures, norms, and policies

    International Nuclear Information System (INIS)

    Katzenstein, P.J.; Okawara, N.

    1993-01-01

    Japan's national security policy has two distinctive aspects that deserve analysis. First, Japan's definition of national security goes far beyond traditional military notions. National security is viewed in comprehensive terms that also include economic and political dimensions. The second feature of Japan's security policy worth explanation is a distinctive mixture of flexibility and rigidity in the process of policy adaptation to change: flexibility on issues of economic security, rigidity on issues of military security, and flexibility combined with rigidity on issues of political security. With the end of the Cold War and changes in the structure of the international system, it is only natural that we ask whether and how Japan's national security policy will change as well. Optimists insist that the Asian balance of power and the US-Japan relationship will make Japan aspire to be a competitive, noninterventionist trading state that heeds the universal interest of peace and profit rather than narrow aspirations for national power. Pessimists warn us instead that the new international system will finally confirm Herman Kahn's prediction of 1970: Japan will quickly change to the status of a nuclear superpower, spurred perhaps by what some see as a dangerous rise of Japanese militarism in the 1970s and 1980s

  18. Analysis of energy intensity in Japan

    International Nuclear Information System (INIS)

    Okajima, Shigeharu; Okajima, Hiroko

    2013-01-01

    This study discusses the causes of the increase in Japan's energy intensity, defined as energy consumption divided by GDP, since the early 1990s. The significant reduction in Japan's energy intensity ceased in the early 1980s and has even slightly increased since the early 1990s, indicating that Japan seemingly stopped taking aggressive action to improve energy use. However, further analysis at prefecture level and sector level provides additional insight on energy intensity trends. To analyze the causes of the increase in Japan's energy intensity, energy intensity is decomposed into energy efficiency (improvements in energy efficiency) and energy activity (structural changes from the secondary sector to the tertiary sector of the economy). Our result indicates that the non-uniform energy intensity trends between prefectures are attributed to a high variability in energy efficiency. At sector level, we estimate the income elasticity of energy consumption in each sector and find that a structural change in energy consumption behaviors occurred in all sectors at different time points. The industrial sector and commercial sector became less energy efficient after 1981 and 1988, respectively, which is presumably responsible for the deterioration of Japan's energy intensity since the early 1990s. - Highlights: • We examine why the reduction in Japan's energy intensity increased in the early 1990s. • There is a high variability in energy intensity trends between regions. • The structural changes in energy consumption behaviors occurred in sector level. • These changes may be responsible for the deterioration of Japan's energy intensity

  19. Japan's new energy policy

    International Nuclear Information System (INIS)

    2014-11-01

    Japan's energy policy is undergoing fundamental changes. The accident at TEPCO's Fukushima Daiichi nuclear power plant questions the future contribution of nuclear power in the national energy mix. Growing imports of fossil fuels to replace the lost nuclear capacity inflated energy prices and raise economic and energy security challenges. At the same time, the US shale gas and oil revolution is reshaping the global energy scene. Japan expects to take advantage of the trend to eliminate the 'Asian premium' on natural gas prices and expand cheaper natural gas consumption. These developments have driven the Government of Japan to review its energy policy from scratch and adopt a new Strategic Energy Plan. This new policy has far reaching implications for gas and coal development in Japan but also for the international markets as Japan is the world's largest LNG importer and the second largest coal importer. This document summarizes the key findings of a new report by CEDIGAZ 'Japan's new energy policy: In search for stable and competitive energy supply'. The report analyzes the current changes taking place on the gas and coal markets in Japan, in light of the new energy policy adopted in April 2014, and in particular the decision to restart safe nuclear power plants and push forward electricity market reforms

  20. Electronic manufacturing and packaging in Japan

    Science.gov (United States)

    Kelly, Michael J.; Boulton, William R. (Editor); Kukowski, John A.; Meieran, Eugene S.; Pecht, Michael; Peeples, John W.; Tummala, Rao R.

    1995-01-01

    This report summarizes the status of electronic manufacturing and packaging technology in Japan in comparison to that in the United States, and its impact on competition in electronic manufacturing in general. In addition to electronic manufacturing technologies, the report covers technology and manufacturing infrastructure, electronics manufacturing and assembly, quality assurance and reliability in the Japanese electronics industry, and successful product realization strategies. The panel found that Japan leads the United States in almost every electronics packaging technology. Japan clearly has achieved a strategic advantage in electronics production and process technologies. Panel members believe that Japanese competitors could be leading U.S. firms by as much as a decade in some electronics process technologies. Japan has established this marked competitive advantage in electronics as a consequence of developing low-cost, high-volume consumer products. Japan's infrastructure, and the remarkable cohesiveness of vision and purpose in government and industry, are key factors in the success of Japan's electronics industry. Although Japan will continue to dominate consumer electronics in the foreseeable future, opportunities exist for the United States and other industrial countries to capture an increasingly large part of the market. The JTEC panel has identified no insurmountable barriers that would prevent the United States from regaining a significant share of the consumer electronics market; in fact, there is ample evidence that the United States needs to aggressively pursue high-volume, low-cost electronic assembly, because it is a critical path leading to high-performance electronic systems.

  1. Targeting protein biotinylation enhances tuberculosis chemotherapy.

    Science.gov (United States)

    Tiwari, Divya; Park, Sae Woong; Essawy, Maram M; Dawadi, Surendra; Mason, Alan; Nandakumar, Madhumitha; Zimmerman, Matthew; Mina, Marizel; Ho, Hsin Pin; Engelhart, Curtis A; Ioerger, Thomas; Sacchettini, James C; Rhee, Kyu; Ehrt, Sabine; Aldrich, Courtney C; Dartois, Véronique; Schnappinger, Dirk

    2018-04-25

    Successful drug treatment for tuberculosis (TB) depends on the unique contributions of its component drugs. Drug resistance poses a threat to the efficacy of individual drugs and the regimens to which they contribute. Biologically and chemically validated targets capable of replacing individual components of current TB chemotherapy are a major unmet need in TB drug development. We demonstrate that chemical inhibition of the bacterial biotin protein ligase (BPL) with the inhibitor Bio-AMS (5'-[ N -(d-biotinoyl)sulfamoyl]amino-5'-deoxyadenosine) killed Mycobacterium tuberculosis ( Mtb ), the bacterial pathogen causing TB. We also show that genetic silencing of BPL eliminated the pathogen efficiently from mice during acute and chronic infection with Mtb Partial chemical inactivation of BPL increased the potency of two first-line drugs, rifampicin and ethambutol, and genetic interference with protein biotinylation accelerated clearance of Mtb from mouse lungs and spleens by rifampicin. These studies validate BPL as a potential drug target that could serve as an alternate frontline target in the development of new drugs against Mtb . Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  2. Chemotherapy for small-cell lung cancer

    International Nuclear Information System (INIS)

    Saito, Hajime; Ogawa, Jun-ichi

    2008-01-01

    The cancer in the title (SCLC) is of a very malignant feature in progression and prognosis and is highly sensitive to chemotherapy (CMT) and radiotherapy (RT) relative to non-SCLC. This paper describes the present state of therapy for the cancer essentially according to its stages/progression. Combination of surgery and neo-adjuvant/adjuvant CMT is recommended for the stage I limited disease (LD), where the metastasis is essentially localized in the chest. PE (cisplatin (CDDP)/etoposide)+accelerated hyper-fractionated RT like that by 45 Gy/30 fractions/3 weeks can be a standard regimen for the stage >II LD, and a phase III trial (JCOG 0202) is now in progress. For the extended disease (ED), treatment with 4-6 cycles of PE+IP (CPT-11/CDDP) is a present standard, and a phase III trial (JCOG 0509) is now conducted for IP vs AP (CDDP/amurubicine (AMR)). CE (CBDCA/etoposide) is widely applied in elderly patients because of its low renal toxicity. For cases with recurrence, no standard regimen is established yet, and a randomized comparative phase III trial (JCOG0605) for PEI is currently done. Although progress of various CMT drugs and regimens has brought about an improvement of outcome (MST: for LD, about 20.3 mo and ED, 9.1 mo vs 12 weeks without treatment), development of molecular target medicine suitable for SCLC is awaited for better prognosis. (R.T.)

  3. Tropical cyclones-Pacific Asian Research Campaign for Improvement of Intensity estimations/forecasts (T-PARCII): A research plan of typhoon aircraft observations in Japan

    Science.gov (United States)

    Tsuboki, Kazuhisa

    2017-04-01

    Typhoons are the most devastating weather system occurring in the western North Pacific and the South China Sea. Violent wind and heavy rainfall associated with a typhoon cause huge disaster in East Asia including Japan. In 2013, Supertyphoon Haiyan struck the Philippines caused a very high storm surge and more than 7000 people were killed. In 2015, two typhoons approached the main islands of Japan and severe flood occurred in the northern Kanto region. Typhoons are still the largest cause of natural disaster in East Asia. Moreover, many researches have projected increase of typhoon intensity with the climate change. This suggests that a typhoon risk is increasing in East Asia. However, the historical data of typhoon include large uncertainty. In particular, intensity data of the most intense typhoon category have larger error after the US aircraft reconnaissance of typhoon was terminated in 1987.The main objective of the present study is improvements of typhoon intensity estimations and of forecasts of intensity and track. We will perform aircraft observation of typhoon and the observed data are assimilated to numerical models to improve intensity estimation. Using radars and balloons, observations of thermodynamical and cloud-microphysical processes of typhoons will be also performed to improve physical processes of numerical model. In typhoon seasons (mostly in August and September), we will perform aircraft observations of typhoons. Using dropsondes from the aircraft, temperature, humidity, pressure, and wind are measured in surroundings of the typhoon inner core region. The dropsonde data are assimilated to a cloud-resolving model which has been developed in Nagoya University and named the Cloud Resolving Storm Simulator (CReSS). Then, more accurate estimations and forecasts of the typhoon intensity will be made as well as typhoon tracks. Furthermore, we will utilize a ground-based balloon with microscope camera, X-band precipitation radar, Ka-band cloud radar

  4. Re-examination on the 1891 M8.0 Nobi Earthquake, Japan: Collspse rate distributions in cities, towns and villages

    Science.gov (United States)

    Kimata, F.; Matta, N.

    2014-12-01

    The 1891 M8.0 Nobi Earthquake is the greatest inland earthquakes in Japan. The Neodani Fault was slipped for 80 km length at the earthquake. Over 7000 peoples was perished around Gifu prefecture, central Japan by the earthquake. It was passed 20 years to be established a constitutional monarchy in Japan, and Meiji government modernized oneself after the West. The cities, towns and villages were decreasing to 15,859 from 71,314 by the community integration in 1888-1889. And yet, there were 61 towns and villages in Motosu county located in the hypocenter of the Nobi earthquake at the time, and there were 33,000 people. The 61 towns and villages were consisting with populations of 114 -3506, and households of 14-3508. Gifu prefecture published a disaster report on the numbers of collapsed house and casualties by the earthquake, including the populations and households on all cities, towns in a week after the earthquake. Already Muramatsu (1983) and Iida (1985) discussed the Gifu prefecture disaster report, and they calculated the collapse rate and estimated the seismic intensities in the towns and villages. However, they never discuss precisely the disaster in each city, town and village. Firstly, we make a distribution map of the completely-collapse rates of the cities, towns and villages in Gifu and Aichi prefectures using GIS software. As Muramatsu already pointed out that there are two regions over 90% of collapse rates precisely. One is located along the Neodani fault, and it is a very narrow area. The other is located wide area in north Nobi Plain. Some research groups suggest another fault named Gifu-Ichinomiya line, because the region of seismic intensity 7 is estimated from Gifu to south Nagoya. However high collapse rate over 90% is not distributed as zones. It is suggested that collapsed houses are increased by shallow ground structures such as alluvium. Surely, alluvium is distributed with thick with 50 m maximally in the region. However, more local

  5. Cutaneous side effects of chemotherapy in pediatric oncology patients.

    Science.gov (United States)

    Ceylan, Can; Kantar, Mehmet; Tuna, Arzu; Ertam, Ilgen; Aksoylar, Serap; Günaydın, Aslı; Çetingül, Nazan

    2015-01-01

    Pediatric oncology patients can present with various skin lesions related to both primary disease and immunosuppressive treatments. This study aimed to evaluate the cutaneous side effects of chemotherapy in pediatric oncology patients. Sixty-five pediatric oncology patients who were scheduled to undergo chemotherapy from May 2011 to May 2013 were included in the study. Three patients were excluded from the results, as 2 patients died during treatment and 1 patient withdrew from the study; therefore, a total of 62 patients were evaluated for mucocutaneous findings. Patients were grouped according to their oncological diagnoses and a statistical analysis was performed. There was no statistical significance in the incidence of cutaneous side effects of chemotherapy among the different diagnostic groups. Awareness among dermatologists of the possible cutaneous side effects of chemotherapy in pediatric patients and their causes can promote early diagnosis and treatment in this patient population.

  6. Combination chemotherapy and immune capacity in advanced ovarian carcinoma

    NARCIS (Netherlands)

    ten Berge, R. J.; Schellekens, P. T.; Hamerlynck, J. V.; Bruning, P. F.

    1984-01-01

    The effects of chemotherapy with either Chap-5 (a drug regimen consisting of adriamycin, cis-dichlorodiammine platinum (II), hexamethylmelamine and cyclophosphamide) or Hexa CAF (a drug regimen consisting of methotrexate, 5-fluorouracil, hexamethylmelamine and cyclophosphamide) on the

  7. Ultrawideband Radio Frequency (RF) Enhanced Electroporation for Chemotherapy

    National Research Council Canada - National Science Library

    Gilgenbach, R. M; Lau, Y. Y; Uhler, M. D; Jordan, D

    2005-01-01

    Experimental results are presented for a research program in which high voltage, short-pulsed, ultrawideband electric fields have been demonstrated to enhance the effects of chemotherapy upon killing of Jurkat (cancer) cells...

  8. Managing Chemotherapy Side Effects: Sexual and Fertility Changes in Men

    Science.gov (United States)

    ... I nstitute Managing Chemotherapy Side Effects Sexual and Fertility Changes in Men “I talked with my doctor ... learn what sexual changes or changes to your fertility you may have. The changes you may have ...

  9. Side Effects of Chemotherapy and Radiation (For Parents)

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Side Effects of Chemotherapy and Radiation KidsHealth / For Parents / Side ... contact your doctor right away. Duration of Side Effects Most side effects go away gradually once cancer ...

  10. Evolution of radiotherapy and chemotherapy practice in malignant gliomas

    Directory of Open Access Journals (Sweden)

    Anusheel Munshi

    2013-01-01

    Full Text Available Malignant astrocytomas of the brain carry a poor prognosis. This article traces the evolution of radiotherapy and chemotherapy practice including the development of concurrent chemo-radiation schedules in the context of these tumors.

  11. Effects of Yifukang Oral Liquid on Chemotherapy- and Radiotherapy ...

    African Journals Online (AJOL)

    Purpose: To investigate the effects of Yifukang oral liquid (YFKOL) on chemotherapy- and radiotherapy-induced myelosuppression, leucopenia and gastrointestinal tract disturbances. Methods: The effects of YFKOL on myelosuppression, leucopenia and gastrointestinal tract disturbances were assessed by ...

  12. Preventing Fatigue in Patients With Breast Cancer Treated with Chemotherapy

    National Research Council Canada - National Science Library

    Marrow, Gary

    2001-01-01

    ... or alleviate the development of treatment-induced fatigue. We conducted a randomized, double-blind, placebo-controlled clinical trial with 124 breast cancer patients who were studied for up to four successive chemotherapy treatments...

  13. Combining Chemotherapy with Bevacizumab Improves Outcomes for Ovarian Cancer Patients

    Science.gov (United States)

    Results from two phase III randomized clinical trials suggest that, at least for some patients with ovarian cancer, adding the antiangiogenesis agent bevacizumab to chemotherapy increases the time to disease progression and may improve survival.

  14. Preoperative Chemotherapy, Radiation Improve Survival in Esophageal Cancer (Updated)

    Science.gov (United States)

    Patients with esophageal cancer who received chemotherapy and radiation before surgery survived, on average, nearly twice as long as patients treated with surgery alone, according to results of a randomized clinical trial published May 31, 2012, in NEJM.

  15. Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication

    Directory of Open Access Journals (Sweden)

    Paul H. Sugarbaker

    2012-01-01

    Full Text Available In patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space. We monitored the intrapleural and plasma levels of mitomycin C and doxorubicin by HPLC assay in order to determine the pharmacokinetic behavior of this intracavitary use of chemotherapy. Our results showed a persistent high concentration of intrapleural drug as compared to plasma concentrations. The increased exposure for mitomycin C was 96, and the increased exposure for doxorubicin was 241. When the clearance of chemotherapy from the thoracic cavity was compared to clearance from the abdomen and pelvis, there was a considerably more rapid clearance from the abdomen as compared to the thorax. The pharmacologic study of intrapleural chemotherapy in these patients provides a strong pharmacologic rationale for regional chemotherapy in this group of patients.

  16. Managing Chemotherapy Side Effects: Skin and Nail Changes

    Science.gov (United States)

    N ational C ancer I nstitute Managing Chemotherapy Side Effects Skin and Nail Changes “I was glad to learn that most skin and nail problems go away after treatment. For now, my nurse told me about ...

  17. Palliative chemotherapy or watchful waiting? A vignettes study among oncologists

    NARCIS (Netherlands)

    Koedoot, C. G.; de Haes, J. C. J. M.; Heisterkamp, S. H.; Bakker, P. J. M.; de Graeff, A.; de Haan, R. J.

    2002-01-01

    Purpose: To determine the preferences of oncologists for palliative chemotherapy or watchful waiting and the factors considered important to that preference. Methods: Sixteen vignettes (paper case descriptions), varying on eight patient and treatment characteristics, were designed to assess the

  18. Survey of Japan: towards greater independence

    International Nuclear Information System (INIS)

    Masters, R.

    1979-01-01

    As a brief introduction to an eight-part survey of Japan, the attitudes and policy of the Japanese to nuclear power is outlined. The government, with its elaborate administrative structure for dealing with all aspects of nuclear power, and its commitments to the nuclear programme, makes great efforts to gain and maintain public support. Having no uranium of her own, Japan attaches great importance to developing the fast breeder and is also committed to a 10 year R and D programme covering all nuclear aspects, from safety to fusion. Japan is also very anxious to develop her own fuel cycle technology and reduce dependence on foreign suppliers. (UK)

  19. The scale of biomass production in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Matsumura, Yukihiko [School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashihiroshima-shi 739-8527 (Japan); Inoue, Takashi; Fukuda, Katsura [Global Warming Research Department, Mitsubishi Research Institute, Inc., 2-3-6 Ohtemachi, Chiyoda-ku, Tokyo 100-8141 (Japan); Komoto, Keiichi; Hada, Kenichiro [Renewable energy Team, Environment, Natural Resources and Energy Division, Mizuho Information and Research Institute, Inc., 2-3 Kanda-nishikicho, Chiyoda-ku, Tokyo 101-8443 (Japan); Hirata, Satoshi [Technical Institute, Kawasaki Heavy Industries, Ltd., 1-1 Kawasakicho, Akashi-shi, Hyogo 673-8666 (Japan); Minowa, Tomoaki [Biomass Recycle Research Laboratory, National Institute of Advanced and Industrial Science and Technology, 2-2-2 Hiro, Suehiro, Kure-shi, Hiroshima 737-0197 (Japan); Yamamoto, Hiromi [Socioeconomic Research Center, Central Research Institute of Electric Power Industry, 1-6-1 Ohtemachi, Chiyoda-ku, Tokyo 100-8126 (Japan)

    2005-11-01

    Policymakers working to introduce and promote the use of bioenergy in Japan require detailed information on the scales of the different types of biomass resources generated. In this research, the first of its type in Japan, the investigators reviewed various statistical resources to quantify the scale distribution of forest residues, waste wood from manufacturing, waste wood from construction, cattle manure, sewage sludge, night soil, household garbage, and waste food oil. As a result, the scale of biomass generation in Japan was found to be relatively small, on the average is no more than several tons in dry weight per day. (author)

  20. Radiation and chemotherapy from the viewpoint of radiochemist

    International Nuclear Information System (INIS)

    Moebius, S.

    1989-01-01

    Fundamentals of radiation and chemotherapy in cancer treatment are presented from the viewpoint of radiochemistry. Properties and mechanism of chemotherapy, especially of platinum compounds are explained. The present state of radiation therapy is shown and possibilities for future reduction of the patients dose burden are discussed. Promising ways are the radiation sensitization of tumor cells by oxygen or the use of particle radiation instead of γ-quants. (orig.) [de

  1. Nursing Care of Patients Undergoing Chemotherapy Desensitization: Part II.

    Science.gov (United States)

    Jakel, Patricia; Carsten, Cynthia; Carino, Arvie; Braskett, Melinda

    2016-04-01

    Chemotherapy desensitization protocols are safe, but labor-intensive, processes that allow patients with cancer to receive medications even if they initially experienced severe hypersensitivity reactions. Part I of this column discussed the pathophysiology of hypersensitivity reactions and described the development of desensitization protocols in oncology settings. Part II incorporates the experiences of an academic medical center and provides a practical guide for the nursing care of patients undergoing chemotherapy desensitization.
.

  2. Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine

    Science.gov (United States)

    Xu, Wei; Beeharry, Maneesh K.; Yan, Min; Zhu, Zhenggang

    2016-01-01

    In spite of the declining incidence of gastric cancer (GC) in recent years, the mortality rate is still high. The asymptomatic nature and nonspecific clinical manifestations combined with the lack of efficient screening programs delay the diagnosis of GC. Therefore, the prevalence of advanced gastric cancer (AGC) has prompted the need for aggressive and intensive treatment options. Among the various treatment options for AGC, surgery is still the mainstay. However, the efficacy of surgery alone is not established. Results from multiple randomized controlled trials suggest that preoperative chemotherapy is promising intervention for the treatment and management of AGC. The main objective of neoadjuvant chemotherapy is to downstage or control micrometastasis in resectable tumor before surgery. On the other hand, conversion chemotherapy refers to surgical treatment aiming at R0 resection after chemotherapy for originally nonresectable or marginally resectable tumors. Nevertheless, preoperative chemoradiotherapy is considered beneficial for AGC patients. Over the last few decades, the combination of chemotherapy and targeted therapy prior to surgery demonstrated great results for the treatment of AGC. The rapid developments in genomics and proteomics have heralded the era of precision medicine. The combination of preoperative chemotherapy and precision medicine may enhance survival in AGC patients. PMID:28105420

  3. Simultaneous radiochemotherapy in cervical cancer: recommendations for chemotherapy

    International Nuclear Information System (INIS)

    Dunst, J.; Haensgen, G.

    2001-01-01

    Background: Simultaneous radiochemotherapy has recently been demonstrated to be superior to radiation alone in the treatment of cervical cancer. The objective of this article is to summarize the data of major randomized trials and to derive recommendations for daily clinical practice. Materials and Methods: We have analyzed the data from seven randomized trials in the recent literature in which radiotherapy alone as standard treatment has been compared to simultaneous radiochemotherapy. Four trials used cisplatin-based chemotherapy regimens, 5-FU, mitomycin C and epirubicin were used each in one trial. Results: All trials demonstrated some improvement in survival which was significant in the studies with cisplatin-based chemotherapy regimens. The survival benefit resulted mainly from an improvement in local control whereas chemotherapy had only a small and insignificant effect on distant metastases. Thus, the main action of chemotherapy is ''radiosensitization''. Cisplatin as single drug yielded comparable results as compared to combined regimens although the cisplatin dose was lower in the studies with combination chemotherapy. For the definitive treatment of locally advanced cancers, monotherapy with cisplatin can be recommended. Mitomycin C offers an attractive alternative to cisplatin in patients with contraindications for cisplatin. For postoperative radiochemotherapy, a combination of cisplatin/5-FU should be used because data with cisplatin alone are lacking so far. Simultaneous radiochemotherapy should also be considered for the curative treatment of local recurrences. Conclusions: The addition of simultaneous chemotherapy to radiotherapy is indicated in the vast majority of patients with cervical cancers who are treated with curative intent. (orig.) [de

  4. Food Irradiation In Vietnam And Japan

    International Nuclear Information System (INIS)

    Tamikazy Kume

    2011-01-01

    In 2008, Japan Atomic Energy Commission of Cabinet Office performed the study of current status of food irradiation in the world. The results showed that the total quantity of irradiated foods in 2005 was 405,000 tons. Seven main countries for food irradiation were China, USA, Ukraine, Brazil, South Africa, Vietnam and Japan. In Japan, only the potato irradiation for sprout inhibition is continued more than 35 years since 1974 but the quantity is decreasing. On the other hand, the food irradiation of Vietnam has been developed rapidly in a short time to export the frozen seafood and fruit. This paper shows the status of food irradiation in Vietnam and Japan, and the progress in both countries after 2005. (author)

  5. Exotic freshwater planarians currently known from Japan

    NARCIS (Netherlands)

    Sluys, R.; Kawakatsu, M.; Yamamoto, K.

    2010-01-01

    Biogeographical and taxonomic information on the four non-indigenous freshwater planarians of Japan is reviewed, viz. Dugesia austroasiatica Kawakatsu, 1985, Girardia tigrina (Girard, 1850), G. dorotocephala (Woodworth, 1897), and Rhodax evelinae? Marcus, 1947. The occurrence of Girardia

  6. May 1983 Akita, Honshu, Japan Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The tsunami generated by a magnitude 7.9 (Mw) earthquake destroyed 700 boats and 59 houses for a total of $800 million in property damage in Japan (1983 dollars)....

  7. History of Nuclear Fusion Research in Japan

    Science.gov (United States)

    Iguchi, Harukazu; Matsuoka, Keisuke; Kimura, Kazue; Namba, Chusei; Matsuda, Shinzaburo

    In the late 1950s just after the atomic energy research was opened worldwide, there was a lively discussion among scientists on the strategy of nuclear fusion research in Japan. Finally, decision was made that fusion research should be started from the basic, namely, research on plasma physics and from cultivation of human resources at universities under the Ministry of Education, Science and Culture (MOE). However, an endorsement was given that construction of an experimental device for fusion research would be approved sooner or later. Studies on toroidal plasma confinement started at Japan Atomic Energy Research Institute (JAERI) under the Science and Technology Agency (STA) in the mid-1960s. Dualistic fusion research framework in Japan was established. This structure has lasted until now. Fusion research activities over the last 50 years are described by the use of a flowchart, which is convenient to glance the historical development of fusion research in Japan.

  8. Civil-Military Relations in Japan

    National Research Council Canada - National Science Library

    Dunn, Timothy

    2003-01-01

    ... instrument of Japanese foreign and domestic policy My purpose in this thesis is to examine Japanese civil-military relations by tracing why and how Japan has successfully subordinated its armed forces...

  9. Utilization of Educational Technology in Japan.

    Science.gov (United States)

    Sakamoto, Takashi

    1980-01-01

    Gives an overview of the development of educational technology in Japan evident in the increase of publications, the diffusion of technological innovations, and the organization of research pertaining to the field. (Author/MER)

  10. United States - Japan - European Union probe data.

    Science.gov (United States)

    2014-01-01

    The U.S., Japan, and Europe have a long : history of sharing information on ITS : activities. These efforts include both bilateral : and trilateral relationships. International : coordination is underway in several areas, : including: : 1. Internatio...

  11. United States-Japan: An Economic View

    National Research Council Canada - National Science Library

    Wall, Walter

    1995-01-01

    ... were. The American people focus inward on their standard of living, the economy, and overall well-being. The strains of trade deficits are tearing at the long established relationship between the United States and Japan...

  12. Summary of the Day Observations - Misawa Japan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Summary of the Day Observations - Misawa Japan is a collection of data summarizing daily weather observations taken at Misawa Naval Air Station, near the north end...

  13. Japan's contribution to nuclear medical research

    International Nuclear Information System (INIS)

    Rahman, M.; Sakamoto, Junichi; Fukui, Tsuguya

    2002-01-01

    We investigated the degree of Japan's contribution to the nuclear medical research in the last decade. Articles published in 1991-2000 in highly reputed nuclear medical journals were accessed through the MEDLINE database. The number of articles having affiliation with a Japanese institution was counted along with publication year. In addition, shares of top-ranking countries were determined along with their trends over time. Of the total number of articles (7,788), Japan's share of articles in selected nuclear medical journals was 11.4% (889 articles) and ranked 2nd in the world after the USA (2,645 articles). The recent increase in the share was statistically significant for Japan (p=0.02, test for trend). Japan's share in nuclear medical research output is much higher than that in other biomedical fields. (author)

  14. Magnetically responsive siliceous frustules for efficient chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Javalkote, Vivek S. [Department of Biotechnology, School of Life Sciences, North Maharashtra University, Jalgaon, Maharashtra (India); Pandey, Abhijeet P. [H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra (India); Puranik, Pravin R. [Department of Biotechnology, School of Life Sciences, North Maharashtra University, Jalgaon, Maharashtra (India); Deshmukh, Prashant K., E-mail: pkdesh@rediffmail.com [H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra (India)

    2015-05-01

    In the present investigation, curcumin loaded magnetically active frustules have been reported. The diatoms were cultured and frustules were obtained by chemical and thermal processes. The frustules were rendered magnetically active by incorporation of iron oxide nanoparticle using two different methods involving ferrofluid (CMDM-F) and in situ synthesis (CMDM-I) of iron oxide nanoparticle. These CMDM prepared by two techniques were characterized using FT-IR and vibrating sample magnetometer (VSM) analyses. Particle size and potential were measured using the Malvern Zetasizer. Scanning electron microscopy (SEM) was utilized for studying the surface morphology of CMDM, and in addition to this elemental analysis was also performed for confirming the presence of iron. The cell viability assay was carried out using the HeLa cell line. SEM images showed a change in surface morphology of diatoms before and after rendering magnetic activity. Cell viability assay revealed that CMDM-F had reasonably high cytotoxicity (60.2%) compared to Curcumin (42.1%), DM (1.9%), CDM (44.8%), and CMDM-I (59.9). Both, CMDM-F and CMDM-I showed improved cytotoxicity when compared with pure curcumin. The overall study suggests that the developed CMDM could be utilized as a potential carrier to deliver cargo for efficient chemotherapy. - Highlights: • In-lab culture and purification of Diatoms with pore size around 50 nm • A simple one step synthesis of magnetically active Diatoms using ferrofluid which has not been reported till date • Comparative study of magnetically active Diatoms synthesized using ferrofluid method and in situ method • Cell viability study of curcumin loaded magnetically active diatoms.

  15. Magnetically responsive siliceous frustules for efficient chemotherapy

    International Nuclear Information System (INIS)

    Javalkote, Vivek S.; Pandey, Abhijeet P.; Puranik, Pravin R.; Deshmukh, Prashant K.

    2015-01-01

    In the present investigation, curcumin loaded magnetically active frustules have been reported. The diatoms were cultured and frustules were obtained by chemical and thermal processes. The frustules were rendered magnetically active by incorporation of iron oxide nanoparticle using two different methods involving ferrofluid (CMDM-F) and in situ synthesis (CMDM-I) of iron oxide nanoparticle. These CMDM prepared by two techniques were characterized using FT-IR and vibrating sample magnetometer (VSM) analyses. Particle size and potential were measured using the Malvern Zetasizer. Scanning electron microscopy (SEM) was utilized for studying the surface morphology of CMDM, and in addition to this elemental analysis was also performed for confirming the presence of iron. The cell viability assay was carried out using the HeLa cell line. SEM images showed a change in surface morphology of diatoms before and after rendering magnetic activity. Cell viability assay revealed that CMDM-F had reasonably high cytotoxicity (60.2%) compared to Curcumin (42.1%), DM (1.9%), CDM (44.8%), and CMDM-I (59.9). Both, CMDM-F and CMDM-I showed improved cytotoxicity when compared with pure curcumin. The overall study suggests that the developed CMDM could be utilized as a potential carrier to deliver cargo for efficient chemotherapy. - Highlights: • In-lab culture and purification of Diatoms with pore size around 50 nm • A simple one step synthesis of magnetically active Diatoms using ferrofluid which has not been reported till date • Comparative study of magnetically active Diatoms synthesized using ferrofluid method and in situ method • Cell viability study of curcumin loaded magnetically active diatoms

  16. Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling

    Science.gov (United States)

    Kram, David E.; Krasnow, Stephanie M.; Levasseur, Peter R.; Zhu, Xinxia; Stork, Linda C.

    2016-01-01

    Background Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL). Sleep disturbance can negatively impact overall quality of life, neurodevelopment, memory consolidation, and wound healing. Hypothalamic orexin neurons are influential wake-promoting neurons, and disturbances in orexin signaling leads to abnormal sleep behavior. A new class of drug, the orexin receptor antagonists, could be an intriguing option for sleep disorders caused by increased orexinergic output. Our aim was to examine the impact of ALL treatment doses of corticosteroids on the orexin system in rodents and in children undergoing treatment for childhood ALL. Methods We administered repeated injections of dexamethasone to rodents and measured responsive orexin neural activity compared to controls. In children with newly diagnosed standard risk B-cell ALL receiving dexamethasone therapy per Children’s Oncology Group (COG) induction therapy from 2014–2016, we collected pre- and during-steroids matched CSF samples and measured the impact of steroids on CSF orexin concentration. Results In both rodents, all markers orexin signaling, including orexin neural output and orexin receptor expression, were preserved in the setting of dexamethasone. Additionally, we did not detect a difference in pre- and during-dexamethasone CSF orexin concentrations in children receiving dexamethasone. Conclusions Our results demonstrate that rodent and human orexin physiology is largely preserved in the setting of high dose dexamethasone. The data obtained in our experimental model fail to demonstrate a causative role for disruption of the orexin pathway in steroid-induced sleep disturbance. PMID:27997622

  17. The application of hyperthermia in regional chemotherapy.

    Science.gov (United States)

    Di Filippo, F; Anzà, M; Rossi, C R; Cavaliere, F; Botti, C; Lise, M; Garinei, R; Giannarelli, D; Vasselli, S; Zupi, G; Cavaliere, R

    1998-01-01

    To evaluate the role of hyperthermia combined with chemotherapy in the loco-regional treatment of tumors, a retrospective analysis was done with 228 limb melanoma patients treated with hyperthermic antiblastic perfusion (HAP). A series of treatment- and tumor-related prognostic factors was analyzed to establish their influence on tumor response, loco-regional control, and survival. Concerning tumor response, the logistic model showed that the number of lesions and the minimal tumor temperature (min T) maintained their individual predictive values (P < 0.000001 and P = 0.04, respectively). For loco-regional control, only the number of lesions had a significant predictive value. No direct correlation was found between the treatment-related variables and loco-regional control. However, the 5-year survival rate was significantly higher for patients who achieved a complete response (CR) (51.5%, P = 0.0033) as compared to those who did not (33.3%), providing indirect evidence of the role of the treatment. Multivariate analysis showed that both disease-free and overall survival are strongly influenced by numerous clinical variables and the min T always maintained its significance. When analyzing the subgroup of 119 patients evaluable for tumor response, the Cox model selected the tumor response as the dominant factor for both disease-free and overall survival. These data seem to demonstrate that the optimization of treatment parameters is crucial in determining the CR rate, which, in turn, positively affects the disease outcome. HAP is the treatment of choice for recurrent limb melanoma, and hyperthermia plays an important role in exploiting the efficacy of this technique.

  18. Induction chemotherapy followed by concurrent radiotherapy and chemotherapy in stage III non-small cell lung cancer

    International Nuclear Information System (INIS)

    Bouillet, T.; MOrere, J.F.; Piperno-Neuman, S.; Boaziz, C.; Breau, J.L.; Mazeron, J.J.; Haddad, E.

    1997-01-01

    The purpose was to determine the efficacy and safety of induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of stage III non-small cell lung cancer and whether the response to induction chemotherapy can predict the response to subsequent chemoradiotherapy and survival. In conclusion, there is a statistically significant relationship not only between the response to ICT and the response to CCrt, but also between the response to ICT and the local outcome and survival. (authors)

  19. Spent fuel management in Japan

    International Nuclear Information System (INIS)

    Mineo, H.; Nomura, Y.; Sakamoto, K.

    1998-01-01

    In Japan 52 commercial nuclear power units are now operated, and the total power generation capacity is about 45 GWe. The cumulative amount of spent fuel arising is about 13,500 tU as of March 1997. Spent fuel is reprocessed, and recovered nuclear materials are to be recycled in LWRs and FBRs. In February 1997 short-term policy measures were announced by the Atomic Energy Commission, which addressed promotion of reprocessing programme in Rokkasho, plutonium utilization in LWRs, spent fuel management, backend measures and FBR development. With regard to the spent fuel management, the policy measures included expansion of spent fuel storage capacity at reactor sites and a study on spent fuel storage away from reactor sites, considering the increasing amount of spent fuel arising. Research and development on spent fuel storage has been carried out, particularly on dry storage technology. Fundamental studies are also conducted to implement the burnup credit into the criticality safety design of storage and transportation casks. Rokkasho reprocessing plant is being constructed towards its commencement in 2003, and Pu utilization in LWRs will be started in 1999. Research and development of future recycling technology are also continued for the establishment of nuclear fuel cycle based on FBRs and LWRs. (author)

  20. From the Jura to Japan...

    CERN Multimedia

    2012-01-01

    Fifty years ago, a week-long school for physicists took place in Saint Cergue, in the Jura mountains not far from CERN. Its focus was on using emulsion techniques, but its legacy was much more far reaching. Last week I was in Fukuoka, Japan, on the last day of a direct descendent – the first Asia–Europe–Pacific School of High-Energy Physics (AEPSHEP).   That first small school in 1962 was the precursor to the annual European Schools of High-Energy Physics, which are organised jointly by CERN and the Joint Institute for Nuclear Research (JINR) in countries that are a member state of either (or both) of the organisations. They led in turn to the CERN–Latin-American School of High-Energy Physics, first held in Brazil in 2001. The aim of these schools is not only to give young particle physicists the opportunity to learn from leading experts in the field, but also to nurture from the start communication among researchers from different regions. CERN and JI...

  1. Nuclear Forensics Technologies in Japan

    International Nuclear Information System (INIS)

    Shinohara, N.; Kimura, Y.; Okubo, A.; Tomikawa, H.

    2015-01-01

    Nuclear forensics is the analysis of intercepted illicit nuclear or radioactive material and any associated material to provide evidence for nuclear attribution by determining origin, history, transit routes and purpose involving such material. Nuclear forensics activities include sampling of the illicit material, analysis of the samples and evaluation of the attribution by comparing the analysed data with database or numerical simulation. Because the nuclear forensics methodologies provide hints of the origin of the nuclear materials used in illegal dealings or nuclear terrorism, it contributes to identify and indict offenders, hence to enhance deterrent effect against such terrorism. Worldwide network on nuclear forensics can lead to strengthening global nuclear security regime. In the ESARDA Symposium 2015, the results of research and development of fundamental nuclear forensics technologies performed in Japan Atomic Energy Agency during the term of 2011-2013 were reported, namely (1) technique to analyse isotopic composition of nuclear material, (2) technique to identify the impurities contained in the material, (3) technique to determine the age of the purified material by measuring the isotopic ratio of daughter thorium to parent uranium, (4) technique to make image data by observing particle shapes with electron microscope, and (5) prototype nuclear forensics library for comparison of the analysed data with database in order to evaluate its evidence such as origin and history. Japan’s capability on nuclear forensics and effective international cooperation are also mentioned for contribution to the international nuclear forensics community.

  2. Romanticising Shinsengumi in Contemporary Japan

    Directory of Open Access Journals (Sweden)

    Rosa Lee

    2011-01-01

    Full Text Available Shinsengumi, a group of young men recruited by the Bakufu to protect Kyoto from radical Imperial House loyalists in the tumultuous Bakumatsu period, is romanticised and idolised in Japan despite its limited place in history. This article attempts to comprehend this phenomenon by locating the closest crystallisation of popularly imagined Shinsengumi in Moeyo ken, a popular historical fiction by Shiba Ryōtarō. Antonio Gramsci explains readers are attracted to popular literature because it reflects their ‘philosophies of the age’, which may be discovered by examining popular heroes with their subsequent replications. This article will identify why Shinsengumi is appealing by comparing Shiba’s hero in Moeyo ken with its twenty-first century reincarnation in Gintama, a popular manga series, and by discerning reader response to Moeyo ken from customer reviews on Amazon.co.jp. It will be demonstrated from these studies that a likely reason for the Japanese public’s romanticisation of Shinsengumi in recent years could be their attraction to autonomous, self-determining heroes who also appreciate the value of community.

  3. [Legislations on radiation in Japan].

    Science.gov (United States)

    Okazaki, Ryuji

    2013-10-01

    The Atomic Energy Basic Act was the first law for the prevention of radiation damage in Japan, and was enforced in 1955. The law focused on the research, development and promotion of the use of atomic energy. With an increase in the importing of radioactive isotopes from foreign countries, the Act on Prevention of Radiation Disease Due to Radioisotopes was established under the jurisdiction of the Science and Technology Agency in 1957 and enforced in 1958. The Nuclear Regulation Authority began as an extra-ministerial committee of the Ministry of the Environment in 2012 and has jurisdiction in the area of ionizing radiations regulations.Substantial regulation has been provided by the Labor Standards Act, and the Ordinance on Prevention of Ionizing Radiation Hazards was established as the eleventh ordinance of the Ministry of Labor in 1959. There have been many revisions to the Ordinance, including revisions following the Fukushima Daiichi Nuclear Power Plant accident in 2011. This paper explains the Act on Prevention of Radiation Disease Due to Radioisotopes, the Ordinance on Prevention of Ionizing Radiation Hazards, and workmen's accident authorization.

  4. Corporate governance and transparency in Japan

    OpenAIRE

    Aman, Hiroyuki; Beekes, Wendy Anne; Brown, Philip Ronald

    2016-01-01

    We investigate the effect of corporate governance on corporate transparency in Japan, as indicated by the richness of the information environment for Japanese companies. We focus on firms’ disclosure frequency, properties of analysts’ forecasts and the speed of price discovery as indicators of corporate transparency. We find corporate governance in Japan is associated with increased disclosure and greater analyst following, but not more timely price discovery. In further analysis, we confirm ...

  5. Epidemiology of diabetes mellitus in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Blackard, W.G.; Omori, Yoshiaki; Freedman, L.R.

    1964-03-12

    The clinical and epidemiological features of diabetes mellitus in Japan have been compiled and compared with data from other countries. Diabetes is basically the same in Japan as elsewhere: however, consideration of important differences has led to the following conclusions: The rarity of ketoacidosis in Japan is due to the mild carbohydrate defect present in most diabetics. The mild carbohydrate intolerance in diabetics is probably in part due to a high carbohydrate intake. Diabetic retinopathy is more common in women than in men in Japan; there are limited and conflicting data from the West on this point, but retinopathy, nephropathy and neuropathy occur about as frequently in Japan as in the West. Because of marked dietary differences between Japan and Western countries, these findings suggest that dietary fat has no significance in the pathogenesis of these lesions. Peripheral gangrene is distinctly unusual in Japanese diabetics. This suggests that either: the responsible vascular lesions are different from those responsible for nephropathy and retinopathy; or that small vessel lesions are the same but the lack of large vessel atherosclerosis in the population accounts for the decreased incidence of gangrene. Men have diabetes 2 or 3 times as commonly as women in Japan. If sex-limited inheritance is discarded as a possible reason, it is likely that adult-onset diabetes is more common in men than women except in those countries (the West) where women gain relatively large amounts of weight. The rarity of juvenile diabetes in Japan is best explained by the infrequency of responsible genetic factors. As a consequence, it is likely that juvenile diabetes is caused by different or additional genetic factors which are not significant in adult-onset diabetes. Diabetes prevalance varies sufficiently between different localities in the same country to render the concept of national prevalance of doubtful usefulness. 55 references, 3 figures, 3 tables.

  6. Explaining Meiji Japan's top-down revolution

    OpenAIRE

    McClain, Kendra M.

    2017-01-01

    Approved for public release; distribution is unlimited Meiji Japanese leaders consisted of an oligarchy that strived to overcome Western imperialist pressures in Asia. They did so by overturning some deeply rooted Tokugawa-Era traditions in Japanese society and replaced them with Western ones. They understood that Western norms dictated world affairs, so they sought to make Japan strong along Western norms. Modeling the West provided enough traction for Japan to meet Western threats and ma...

  7. Status of historical seismology in Japan

    OpenAIRE

    Ishibashi, K.

    2004-01-01

    Japan's combination of high seismicity and a long history has produced copious written records of historical earthquakes. Systematic collection and investigation of such historical documents began late in the 19th century. Now, almost all of Japan's known historical materials on earthquakes have been transcribed into 25 printed volumes. The collections include records of about 400 destructive earthquakes from A.D. 599 to 1872. Epicentral coordinates and magnitudes have been estimated for abou...

  8. Revitalizing US electronics lessons from Japan

    CERN Document Server

    Sprague, John

    1993-01-01

    Written by one of the few executives who have extensive experience in the electronics industry in both the US and Japan, this book compares market research, design, and manufacturing techniques as used in both countries. Unlike other books on theJapanese business culture, Sprague gives specific advice and recommendations about what companies can do now to compete with Japan, clearly pointing out what is and what is not adaptable from the Japanese approach to business.

  9. Recruitment of Foreign Residents in Japan

    OpenAIRE

    Tong, Yaqina

    2016-01-01

    International migration, in response to economic globalization, is rapidly increasing in various countries, including Japan. Japan is currently experiencing a serious decline in birth rate, an aging society, and a shortage of labor forces. However, the supply and demand between job-seeking foreigners and job-offering local companies are growing rapidly. Staffing agencies play a mediator role between job seekers and local companies to solve these labor-shortage problems. These agencies conduct...

  10. Proto-Industrialization in Tokugawa Japan

    OpenAIRE

    Murphy, Martin J.

    2012-01-01

    This research examines the process of early capitalism in Japanese history. Generally it is thought that capitalism developed in the years leading to the Meiji Restoration. Like European models of early capitalist development in handicraft and cottage industries, Japan went through a similar process. Development of rural trade and small-scale capitalism sowed the seeds that broke feudal bonds and resulted in the mass factory system that made modern capitalist Japan.

  11. Monitoring Obesity Trends in Health Japan 21.

    Science.gov (United States)

    Nishi, Nobuo

    2015-01-01

    Prevention of non-communicable diseases is more important than ever especially for the elderly to live a healthy life in the super-aged society of Japan. In 2000, the Ministry of Health, Labor and Welfare of Japan started Health Japan 21 as goal-oriented health promotion plan like Healthy People in the US and the Health of the Nation in the UK. Its second term started in 2013 with the aim of prolonging healthy life expectancy and reducing health inequalities. Improvement in both individuals' lifestyle and their social environment will help achieve the goal of the 2nd Health Japan 21. The National Health and Nutrition Survey (NHNS) is conducted every year to monitor the health and nutritional situation of the Japanese using a representative population. The NHNS data are useful for target setting and evaluation of the 2nd Health Japan 21, and the NHNS has shown an increasing trend of overweight (BMI≥25) only for male adults in the most recent 10 y. In contrast, the dietary intake survey of the NHNS shows a decreasing trend of total energy intake both in male and female adults aged 69 y old or younger, and the trend for physical activity is not well known. Thus, we need further investigations on the causes of the obesity trend in Japan.

  12. Progress in infant health in Okinawa, Japan.

    Science.gov (United States)

    Hokama, Tomiko; Binns, Colin

    2012-07-01

    The infant mortality rate (IMR) and neonatal mortality rate (NMR) defined as the number of infant and newborn deaths per 1000 live births, respectively, are widely accepted as population indicators of the level of perinatal and postnatal health. Since the end of World War II, Japan has made substantial progress in reducing its IMR and NMR. This resulted from improving living standards and the provision of universal maternal and child health care (MCH) services. Okinawa, the island prefecture that is the furthest from mainland Japan, had the third highest IMR and the highest low-birth-weight rate (LBW) among all prefectures when its statistics were integrated into Japan in 1973. Even though the LBW rate in Okinawa has remained higher than the all-Japan average, Okinawa has shown a considerable improvement in IMR and NMR. The aim is to review the trends in IMR, NMR, and LBW in Japan and Okinawa and to discuss sociodemographic trends, economics, and the provision of health care services. The IMR and NMR in Okinawa decreased during that time from 14.8 to 2.4 and from 7.5 to 0.8, respectively. The LBW rate decreased until the mid-1980s, but since then it has increased to 11.5 (Okinawa) and 9.6 (Japan) in 2009. Okinawa's public health and primary health care model for infants has been very successful and may be applicable to child health in island nations of the Asia-Pacific region.

  13. Intra-arterial chemotherapy for locally advanced bladder cancer

    International Nuclear Information System (INIS)

    Aota, Yasuhiro; Yoshida, Kazuhiko

    1999-01-01

    A total of 83 patients with locally advanced bladder cancer (T1, n=5; T2, n=28; T3a, n=21; T3b, n=21; T4, n=8) were treated with intra-arterial (i.a.) cisplatin and adriamycin (or epirubicin) chemotherapy. In 51 of the 83 cases, we combined this treatment with radiotherapy. The pathological complete response (CR) rate was 68% for all patients, 84% for i.a. chemotherapy combined with radiotherapy and only 41% for i.a. chemotherapy. The 5-year survival rate was 57% for all patients, 71% for i.a. chemotherapy combined with radiotherapy and only 44% for i.a. chemotherapy. The 5-year survival as a function of the clinical stage was 82% for T1+T2, 66% for T3a, 28% for T3b, 25% for T4 (T1+T2 vs. T3b: p<0.001, T1+T2 vs. T4: p<0.0001, T3a vs. T3b: p<0.0263, T3a vs. T4: p<0.0214, T3b vs. T4: p<0.029). In 46% of all patients, we succeeded in preserving the bladder; especially noteworthy, is that in 65% of the patients undergoing i.a. chemotherapy combined with radiotherapy, we succeeded in preserving the bladder. These results demonstrate that i.a. chemotherapy combined with radiotherapy is a useful method for locally advanced bladder cancer which may make preservation of the bladder function feasible. (author)

  14. Symptom Cluster Trajectories During Chemotherapy in Breast Cancer Outpatients.

    Science.gov (United States)

    Hsu, Hsin-Tien; Lin, Kuan-Chia; Wu, Li-Min; Juan, Chiung-Hui; Hou, Ming-Feng; Hwang, Shiow-Li; Liu, Yi; Dodd, Marylin J

    2017-06-01

    Breast cancer patients often experience multiple symptoms and substantial discomfort. Some symptoms may occur simultaneously and throughout the duration of chemotherapy treatment. The aim of this study was to investigate symptom severity and symptom cluster trajectories during chemotherapy in outpatients with breast cancer in Taiwan. This prospective, longitudinal, repeated measures study administered a standardized questionnaire (M. D. Anderson Symptom Inventory Taiwan version) to 103 breast cancer patients during each day of the third 21-day cycle of chemotherapy. Latent class growth analysis was performed to examine symptom cluster trajectories. Three symptom clusters were identified within the first 14 days of the 21-day chemotherapy cycle: the neurocognition cluster (pain, shortness of breath, vomiting, memory problems, and numbness/tingling) with a trajectory of Y = 2.09 - 0.11 (days), the emotion-nausea cluster (nausea, disturbed sleep, distress/upset, drowsiness, and sadness) with a trajectory ofY = 3.57 - 0.20 (days), and the fatigue-anorexia cluster (fatigue, lack of appetite, and dry mouth) with a trajectory of Y = 4.22 - 0.21 (days). The "fatigue-anorexia cluster" and "emotion-nausea cluster" peaked at moderate levels on chemotherapy days 3-5, and then gradually decreased to mild levels within the first 14 days of the 21-day chemotherapy cycle. Distinct symptom clusters were observed during the third cycle of chemotherapy. Systematic and ongoing evaluation of symptom cluster trajectories during cancer treatment is essential. Healthcare providers can use these findings to enhance communication with their breast cancer patients and to prioritize symptoms that require attention and intervention. Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  15. Complications in the central nervous system during chemotherapy for childhood acute lymphoblastic leukemia. JACLS ALL-02 study

    International Nuclear Information System (INIS)

    Umeda, Katsutsugu; Yoshida, Makoto; Suzuki, Nobuhiro

    2007-01-01

    We evaluated central nervous system (CNS) complications treated under the ALL-02 protocol of the Japan Association of Childhood Leukemia Study (JACLS) from April 2002 to March 2005. According to National Cancer Institute (NCI) Toxicity Criteria, 17 events of grade 3 and 4 CNS complications were reported in 15 out of 541 patients. Out of these CNS complications, leukoencephalopathy was seen in 5 patients; seizure in 5; cerebrovascular disease in 3; conscious disturbance in 2; and hypertensive encephalopathy and reversible posterior leukoencephalopathy syndrome in one patient each. The complications were intensively observed during induction therapy and the last of the early phase chemotherapy. The protocol treatment was stopped or modified in most patients after CNS complications. MRI imaging demonstrated no improvement in one patient with leukoencephalopathy who developed an isolated CNS relapse, while other patients were alive and remain in their first complete remission without any neurological sequelae. Further studies will be required to analyze risk factors for CNS complications during chemotherapy not accompanied by irradiation and to establish alternative treatments after the appearance of such CNS complications. (author)

  16. Ocean Science Communication in Japan

    Science.gov (United States)

    Ichikawa, H.

    2011-12-01

    Ocean literacy and education panel (OLEP) of the Oceanographic Society of Japan (JOS) has been established in 2003 for sharing the ocean literacy with the public and promoting the ocean science education in school and college. Its activities include publishing reference books and electronic teaching materials for primary school teachers and students, conducting surveys on the people's consciousness on the ocean, and supporting the events such as 'Ocean Science Cafe' for the public, oceanographer's talks in class room and sea side, and seminars on board of research vessel for high-school teachers and students. Its activities are announced to the public in its website and through Twitter. The records are available to the public in the websites. Some JOS members including me are telling the public the basic knowledge of ocean science, additional explanations to scientific topics in mass media, their thoughts on the ocean, the science, and STEM education, and their daily life such as travels, meetings and cruises through their own private websites, blogs, and accounts in Twitter and Facebook. In this presentation, as a coordinator of the 'Ocean Science Cafe', I will indicate how well it has worked as a good method for promoting mutual communication between non-professional citizens and oceanographers, and changed a scientist to a better citizen. Also, as an ocean science blogger, I will mention a good effect of the mutual communication with the public from my experience. It is concluded that the science communication by new media should not be one-way but really two-way to understand well what people wish to know and have difficulties to understand, and where they stop learning.

  17. Future Accelerators Seminar in Japan

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    ICFA, the International Committee for Future Accelerators, was set up by the Particles and Fields Commission of the International Union of Pure and Applied Physics (IUPAP) in 1976. Its mandate was 'To organize workshops for the study of problems related to an international super-high energy accelerator complex (VBA) and to elaborate the framework of its construction and of its use. To organize meetings for the exchange of information on future plans of regional facilities and for the formulation of advice on joint studies and uses.' In the seven years of its existence (it first met in August 1977), ICFA has organized three workshops on the first topic — t w o on 'Possibilities and Limitations of Accelerators and Detectors' (Fermilab, 1978 and Les Diablerets, 1979) and one on 'Possibilities and Limitations for Superconducting Accelerator Magnets' (Protvino, 1981). At an ICFA meeting at Fermilab in August 1983, it was realized that the second topic had been somewhat neglected. It was therefore decided to postpone a fourth workshop scheduled at the Japanese National Laboratory for High Energy Physics (KEK) and to organize instead a Seminar on 'Future Perspectives in High Energy Physics' similar to that held in New Orleans in 1975, which had in fact led to the creation of ICFA.The Seminar (jointly hosted by the Institute of Nuclear Study of Tokyo University and KEK, with support from the Ministry of Education, Science and Culture, the Yamada Science Foundation and the Nishina Memorial Foundation) took place from 14-20 May. There were about a hundred participants, mostly senior scientists from Western and Eastern Europe, USA, USSR and Japan (including the Directors of almost all the major high energy physics Laboratories) and representatives from Australia, Canada, China, India, Mexico, South Korea and Vietnam

  18. A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic colorectal cancer.

    Science.gov (United States)

    Cao, Yunfei; Tan, Aihua; Gao, Feng; Liu, Lidan; Liao, Cun; Mo, Zengnan

    2009-06-01

    Bevacizumab has demonstrated survival benefit in metastatic colorectal cancer (mCRC) patients when combined with chemotherapy. Several randomized clinical studies have evaluated bevacizumab in combination with chemotherapy. Meta-analysis was performed to better assess the efficacy and safety of bevacizumab with chemotherapy for mCRC. Five clinical trials randomizing a total of 3,103 mCRC patients to chemotherapy alone or to the combined treatment of chemotherapy plus bevacizumab were identified. The efficacy data included progression-free survival (PFS), overall survival (OS), and overall response rate (ORR), and the safety data contained the 60-day all-cause mortality rate, adverse events (AEs), and specific toxicity such as hypertension, thrombosis, bleeding, proteinuria, gastrointestinal perforation, diarrhea, and leucopenia. There was a significant PFS benefit (P = 0.00; hazards ratio [HR] = 0.66) and OS benefit (P = 0.00; HR = 0.77) in favor of the combined treatment. The ORR was significantly higher on the bevacizumab-containing arm (P = 0.021; relative risk [RR] = 1.5), while CR was comparable between the two arms (P = 0.09). A higher incidence of grade 3/4 AEs, grade 3/4 hypertension, grade 3/4 thromboembolic/thrombotic events, grade 3/4 bleeding, and gastrointestinal perforation was associated with the bevacizumab group. The two treatment groups were similar in terms of grade 3/4 proteinuria, grade 3/4 leukopenia, grade 3/4 diarrhea, and the 60-day all-cause mortality rate. The addition of bevacizumab to chemotherapy confers a clinically meaningful and statistically significant improvement in OS, PFS, and ORR. Its side effects are predictable and manageable and do not compound the incidence or severity of toxicities from chemotherapy.

  19. Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines

    International Nuclear Information System (INIS)

    Weir, Genevieve M.; Liwski, Robert S.; Mansour, Marc

    2011-01-01

    Chemotherapy has been a mainstay in cancer treatment for many years. Despite some success, the cure rate with chemotherapy remains unsatisfactory in some types of cancers, and severe side effects from these treatments are a concern. Recently, understanding of the dynamic interplay between the tumor and immune system has led to the development of novel immunotherapies, including cancer vaccines. Cancer vaccines have many advantageous features, but their use has been hampered by poor immunogenicity. Many developments have increased their potency in pre-clinical models, but cancer vaccines continue to have a poor clinical track record. In part, this could be due to an inability to effectively overcome tumor-induced immune suppression. It had been generally assumed that immune-stimulatory cancer vaccines could not be used in combination with immunosuppressive chemotherapies, but recent evidence has challenged this dogma. Chemotherapies could be used to condition the immune system and tumor to create an environment where cancer vaccines have a better chance of success. Other types of immunotherapies could also be used to modulate the immune system. This review will discuss how immune modulation by chemotherapy or immunotherapy could be used to bolster the effects of cancer vaccines and discuss the advantages and disadvantages of these treatments

  20. High-pressure intrapleural chemotherapy: feasibility in the pig model

    Directory of Open Access Journals (Sweden)

    Facy Olivier

    2012-02-01

    Full Text Available Abstract Background The usual treatments for pleural malignancies are mostly palliative. In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown to increase antitumor efficacy, we applied the concept of high-pressure intracavitary chemotherapy to the pleural space in a swine model. Methods Cisplatin and gemcitabine were selected because of their antineoplasic efficacy in vitro in a wide spectrum of cancer cell lines. The pleural cavity of 21 pigs was filled with saline solution; haemodynamic and respiratory parameters were monitored. The pressure was increased to 15-25 cm H2O. This treatment was associated with pneumonectomy in 6 pigs. Five pigs were treated with chemotherapy under pressure. Results The combination of gemcitabine (100 mg/l and cisplatin (30 mg/l was highly cytotoxic in vitro. The maximum tolerated pressure was 20 cm H20, due to haemodynamic failure. Pneumonectomy was not tolerated, either before or after pleural infusion. Five pigs survived intrapleural chemotherapy associating gemcitabine and cisplatin with 20 cm H2O pressure for 60 min. Conclusions High-pressure intrapleural chemotherapy is feasible in pigs. Further experiments will establish the pharmacokinetics and determine whether the benefit already shown in the peritoneum is also obtained in the pleura.

  1. Palliative chemotherapy: The perspectives and experiences of south african nurses

    Directory of Open Access Journals (Sweden)

    Johanna Elizabeth Maree

    2018-01-01

    Full Text Available Objective: The objective of this study was to describe the perspectives and experiences of South African nurses caring for patients receiving palliative chemotherapy. Methods: A qualitative descriptive design was used and purposive sampling allowed us to select 11 nurses practising in a private ambulatory cancer care center in Port Elizabeth. In-depth interviews, guided by three broad themes were conducted and analyzed using qualitative content analyses. Data saturation determined the sample size. Results: Two themes emerged from the data – the patients cling to hope and the positive influence of palliative chemotherapy. The participants believed that patients consenting to palliative chemotherapy were clinging to false hope. They were also of the opinion that family members pressurize patients to consent to treatment. The participants experienced palliative chemotherapy positively, especially when an improvement in the patients' quality of life or pain relief was evident. Fatigue was highlighted as the major side effect, but it did not temper the participants' positive attitudes toward the treatment. Conclusions: Although the participants believed that patients cling to hope and consent to palliative chemotherapy because they hope to be cured, they experienced the treatment as positive. For them, the improvement in pain and quality of life outweighed the side effects the patients experienced. The positive attitude patients upheld while receiving this treatment encouraged them. Nurses should gain more knowledge about the meaning, people living with advanced cancer, attach to hope to prevent them from interpreting patients' hope as denial and false.

  2. High-risk bladder cancer: improving outcomes with perioperative chemotherapy

    Directory of Open Access Journals (Sweden)

    Daniel Y.C. Heng

    2011-12-01

    Full Text Available Despite treatment with radical cystectomy and pelvic lymph node dissection, muscle invasive bladder cancer has a relapse rate of 50%. Patients can develop regionally advanced or metastatic disease that ultimately leads to death. The addition of neoadjuvant or adjuvant chemotherapy to reduce the risk of relapse and death has been extensively studied over the past two decades. Two contemporary trials coupled with a recent meta-analysis evaluating neoadjuvant chemotherapy demonstrated a modest but real improvement in overall survival. This has made neoadjuvant chemotherapy a standard of care. Clinical trials evaluating adjuvant chemotherapy in patients with high-risk disease have been plagued with statistical flaws and have, therefore, been unable to define the survival impact of this approach. It is hoped that ongoing adjuvant trials that are powered to detect small but meaningful clinical differences will clarify the benefit of chemotherapy after cystectomy. Since there are theoretical advantages and disadvantages to each of these approaches, both are widely used in North America. The evidence behind each approach and potential future developments in this field will be described.

  3. Metronomic Chemotherapy: Low Dose Less Toxicity Anticancer Strategy

    Directory of Open Access Journals (Sweden)

    Anjan Khadka

    2016-06-01

    Full Text Available Metronomic chemotherapy is the frequent administration of chemotherapy drugs at doses below the maximum tolerated dose and with no prolonged drug‑free break. It thus achieves a sustained low blood level of the drug without significant toxic side‑effects. Metronomic therapy leads to sustained plasma concentration of the drug without significant toxic side‑effects and hence there is reduced need for supportive therapy. However in case of conventional therapy toxicity is a concern. Metronomic chemotherapy exerts both direct and indirect effects on tumor cells and their microenvironment. It can inhibit tumor angiogenesis, stimulate anticancer immune response and also induces tumor dormancy. Optimizing a metronomic anticancer therapy is still a challenging task. New strategies are being developed to combine metronomic chemotherapy with conventional chemotherapy, radiotherapy and/or targeted therapy. An important disadvantage of this type of regimen is the empiricism in finding the optimal ‘low‑dose’ and in monitoring therapeutic efficacy during the course of treatment.

  4. Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines

    Energy Technology Data Exchange (ETDEWEB)

    Weir, Genevieve M. [Suite 411, 1344 Summer St., Immunovaccine Inc., Halifax, NS, B3H 0A8 (Canada); Room 11-L1, Sir Charles Tupper Building, Department of Microbiology & Immunology, Dalhousie University, 5850 College St, Halifax, NS, B3H 1X5 (Canada); Liwski, Robert S. [Room 11-L1, Sir Charles Tupper Building, Department of Microbiology & Immunology, Dalhousie University, 5850 College St, Halifax, NS, B3H 1X5 (Canada); Room 206E, Dr. D. J. Mackenzie Building, Department of Pathology, Dalhousie University, 5788 University Avenue, Halifax, NS, B3H 2Y9 (Canada); Mansour, Marc [Suite 411, 1344 Summer St., Immunovaccine Inc., Halifax, NS, B3H 0A8 (Canada)

    2011-08-05

    Chemotherapy has been a mainstay in cancer treatment for many years. Despite some success, the cure rate with chemotherapy remains unsatisfactory in some types of cancers, and severe side effects from these treatments are a concern. Recently, understanding of the dynamic interplay between the tumor and immune system has led to the development of novel immunotherapies, including cancer vaccines. Cancer vaccines have many advantageous features, but their use has been hampered by poor immunogenicity. Many developments have increased their potency in pre-clinical models, but cancer vaccines continue to have a poor clinical track record. In part, this could be due to an inability to effectively overcome tumor-induced immune suppression. It had been generally assumed that immune-stimulatory cancer vaccines could not be used in combination with immunosuppressive chemotherapies, but recent evidence has challenged this dogma. Chemotherapies could be used to condition the immune system and tumor to create an environment where cancer vaccines have a better chance of success. Other types of immunotherapies could also be used to modulate the immune system. This review will discuss how immune modulation by chemotherapy or immunotherapy could be used to bolster the effects of cancer vaccines and discuss the advantages and disadvantages of these treatments.

  5. Safety and efficacy of pegfilgrastim in patients receiving myelosuppressive chemotherapy.

    Science.gov (United States)

    Crawford, Jeffrey

    2003-08-01

    The major dose-limiting toxicity associated with myelosuppressive chemotherapy is neutropenia, which can be ameliorated with proactive administration of granulocyte colony-stimulating factor (G-CSF). Pegfilgrastim is a long-acting G-CSF, recently approved by the Food and Drug Administration. The efficacy and safety of pegfilgrastim administered once/chemotherapy cycle have been evaluated in clinical trials involving patients treated with myelosuppressive chemotherapy for breast cancer, lung cancer, non-Hodgkin's lymphoma, and Hodgkin's disease. Two pivotal phase III trials in patients with breast cancer showed that pegfilgrastim is as effective as filgrastim regarding the primary efficacy end point, which was duration of grade 4 (severe) neutropenia in cycle 1 of myelosuppressive chemotherapy. Secondary end points were the frequency of fever with neutropenia (febrile neutropenia), duration of neutropenia in cycles 2-4, depth of the absolute neutrophil count (ANC) nadir, and time to ANC recovery in cycles 1-4. Once/cycle pegfilgrastim 100 microg/kg or 6 mg was as safe and effective as daily filgrastim 5 microg/kg in reducing the frequency and duration of severe neutropenia. A trend toward a greater reduction in the overall frequency of febrile neutropenia with pegfilgrastim was observed. The availability of pegfilgrastim simplifies the use of prophylactic G-CSF, with the potential to increase patient convenience and adherence in management of chemotherapy-induced neutropenia.

  6. Focal laser treatment in addition to chemotherapy for retinoblastoma.

    Science.gov (United States)

    Fabian, Ido D; Johnson, Kenneth P; Stacey, Andrew W; Sagoo, Mandeep S; Reddy, M A

    2017-06-07

    Retinoblastoma is the most common primary intraocular malignancy of childhood. Systemic chemotherapy is a common treatment for intraocular retinoblastoma, and laser treatment is used as adjuvant therapy during or immediately after chemotherapy courses in selected cases. To compare the effectiveness and safety of adding focal laser therapy to systemically-delivered chemotherapy in treating intraocular retinoblastoma. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 9), MEDLINE Ovid (1946 to 20 October 2016), Embase Ovid (1980 to 20 October 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 20 October 2016), the ISRCTN registry (www.isrctn.com/editAdvancedSearch); searched 20 October 2016, ClinicalTrials.gov (www.clinicaltrials.gov); searched 20 October 2016, and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en); searched 20 October 2016. We did not use any date or language restrictions in the electronic searches for trials. We searched for randomised controlled trials (RCTs) of systemic chemotherapy with versus without adjuvant laser therapy for postequatorial retinoblastoma. We planned to use standard methodological procedures expected by Cochrane. We planned to meta-analyse the primary outcome, that is the proportion of eyes with recurrence of tumours within three years from treatment MAIN RESULTS: No studies met the inclusion criteria for this review. No evidence from randomised controlled trials was found to support or refute laser therapy in addition to systemic chemotherapy for postequatorial retinoblastoma.

  7. Reconsidering Japan's underperformance in pharmaceuticals: evidence from Japan's anticancer drug sector.

    Science.gov (United States)

    Umemura, Maki

    2010-01-01

    Unlike its automobile or electronics industries, Japan's pharmaceutical industry did not become a global leader. Japan remains a net importer of pharmaceuticals and has introduced few global blockbuster drugs. Alfred Chandler argued that Japan's pharmaceutical firms remained relatively weak because Western firms enjoyed an insurmountable first first-mover advantage. However, this case study of the anticancer drug sector illustrates that Chandler's explanation is incomplete. Japanese medical culture, government policy, and research environment also played a substantial role in shaping the industry. In the 1970s and 1980s, these factors encouraged firms to develop little few effective drugs with low side effects, and profit from Japan's domestic market. But, these drugs were unsuitable to foreign markets with more demanding efficacy standards. As a result, Japan not only lost more than a decade in developing ineffective drugs, but also neglected to create the infrastructure necessary to develop innovative drugs and build a stronger pharmaceutical industry.

  8. A prospective earthquake forecast experiment for Japan

    Science.gov (United States)

    Yokoi, Sayoko; Nanjo, Kazuyoshi; Tsuruoka, Hiroshi; Hirata, Naoshi

    2013-04-01

    One major focus of the current Japanese earthquake prediction research program (2009-2013) is to move toward creating testable earthquake forecast models. For this purpose we started an experiment of forecasting earthquake activity in Japan under the framework of the Collaboratory for the Study of Earthquake Predictability (CSEP) through an international collaboration. We established the CSEP Testing Centre, an infrastructure to encourage researchers to develop testable models for Japan, and to conduct verifiable prospective tests of their model performance. On 1 November in 2009, we started the 1st earthquake forecast testing experiment for the Japan area. We use the unified JMA catalogue compiled by the Japan Meteorological Agency as authorized catalogue. The experiment consists of 12 categories, with 4 testing classes with different time spans (1 day, 3 months, 1 year, and 3 years) and 3 testing regions called All Japan, Mainland, and Kanto. A total of 91 models were submitted to CSEP-Japan, and are evaluated with the CSEP official suite of tests about forecast performance. In this presentation, we show the results of the experiment of the 3-month testing class for 5 rounds. HIST-ETAS7pa, MARFS and RI10K models corresponding to the All Japan, Mainland and Kanto regions showed the best score based on the total log-likelihood. It is also clarified that time dependency of model parameters is no effective factor to pass the CSEP consistency tests for the 3-month testing class in all regions. Especially, spatial distribution in the All Japan region was too difficult to pass consistency test due to multiple events at a bin. Number of target events for a round in the Mainland region tended to be smaller than model's expectation during all rounds, which resulted in rejections of consistency test because of overestimation. In the Kanto region, pass ratios of consistency tests in each model showed more than 80%, which was associated with good balanced forecasting of event

  9. Anomalous effect in Schumann resonance phenomena observed in Japan, possibly associated with the Chi-chi earthquake in Taiwan

    Directory of Open Access Journals (Sweden)

    M. Hayakawa

    2005-06-01

    Full Text Available The Schumann resonance phenomenon has been monitored at Nakatsugawa (near Nagoya in Japan since the beginning of 1999, and due to the occurance of a severe earthquake (so-called Chi-chi earthquake on 21 September 1999 in Taiwan we have examined our Schumann resonance data at Nakatsugawa during the entire year of 1999. We have found a very anomalous effect in the Schumann resonance, possibly associated with two large land earthquakes (one is the Chi-chi earthquake and another one on 2 November 1999 (Chia-yi earthquake with a magnitude again greater than 6.0. Conspicuous effects are observed for the larger Chi-chi earthquake, so that we summarize the characteristics for this event. The anomaly is characterized mainly by the unusual increase in amplitude of the fourth Schumann resonance mode and a significant frequency shift of its peak frequency (~1.0Hz from the conventional value on the By magnetic field component which is sensitive to the waves propagating in the NS meridian plane. Anomalous Schumann resonance signals appeared from about one week to a few days before the main shock. Secondly, the goniometric estimation of the arrival angle of the anomalous signal is found to coincide with the Taiwan azimuth (the unresolved dual direction indicates toward South America. Also, the pulsed signals, such as the Q-bursts, were simultaneously observed with the "carrier" frequency around the peak frequency of the fourth Schumann resonance mode. The anomaly for the second event for the Chia-yi earthquake on 2 November had much in common. But, most likely due to a small magnitude, the anomaly appears one day before and lasts until one day after the main shock, with the enhancement at the fourth Schumann resonance mode being smaller in amplitude than the case of the Chi-chi earthquake. Yet, the other characteristics, including the goniometric direction finding result, frequency shift, etc., are nearly the same. Although the emphasis of

  10. Anomalous effect in Schumann resonance phenomena observed in Japan, possibly associated with the Chi-chi earthquake in Taiwan

    Directory of Open Access Journals (Sweden)

    M. Hayakawa

    2005-06-01

    Full Text Available The Schumann resonance phenomenon has been monitored at Nakatsugawa (near Nagoya in Japan since the beginning of 1999, and due to the occurance of a severe earthquake (so-called Chi-chi earthquake on 21 September 1999 in Taiwan we have examined our Schumann resonance data at Nakatsugawa during the entire year of 1999. We have found a very anomalous effect in the Schumann resonance, possibly associated with two large land earthquakes (one is the Chi-chi earthquake and another one on 2 November 1999 (Chia-yi earthquake with a magnitude again greater than 6.0. Conspicuous effects are observed for the larger Chi-chi earthquake, so that we summarize the characteristics for this event. The anomaly is characterized mainly by the unusual increase in amplitude of the fourth Schumann resonance mode and a significant frequency shift of its peak frequency (~1.0Hz from the conventional value on the By magnetic field component which is sensitive to the waves propagating in the NS meridian plane. Anomalous Schumann resonance signals appeared from about one week to a few days before the main shock. Secondly, the goniometric estimation of the arrival angle of the anomalous signal is found to coincide with the Taiwan azimuth (the unresolved dual direction indicates toward South America. Also, the pulsed signals, such as the Q-bursts, were simultaneously observed with the "carrier" frequency around the peak frequency of the fourth Schumann resonance mode. The anomaly for the second event for the Chia-yi earthquake on 2 November had much in common. But, most likely due to a small magnitude, the anomaly appears one day before and lasts until one day after the main shock, with the enhancement at the fourth Schumann resonance mode being smaller in amplitude than the case of the Chi-chi earthquake. Yet, the other characteristics, including the goniometric direction finding result, frequency shift, etc., are nearly the same. Although the emphasis of the present study is

  11. Electronics manufacturing and assembly in Japan

    Science.gov (United States)

    Kukowski, John A.; Boulton, William R.

    1995-02-01

    In the consumer electronics industry, precision processing technology is the basis for enhancing product functions and for minimizing components and end products. Throughout Japan, manufacturing technology is seen as critical to the production and assembly of advanced products. While its population has increased less than 30 percent over twenty-five years, Japan's gross national product has increase thirtyfold; this growth has resulted in large part from rapid replacement of manual operations with innovative, high-speed, large-scale, continuously running, complex machines that process a growing number of miniaturized components. The JTEC panel found that introduction of next-generation electronics products in Japan goes hand-in-hand with introduction of new and improved production equipment. In the panel's judgment, Japan's advanced process technologies and equipment development and its highly automated factories are crucial elements of its domination of the consumer electronics marketplace - and Japan's expertise in manufacturing consumer electronics products gives it potentially unapproachable process expertise in all electronics markets.

  12. Middle term prospects for Japan's safeguards

    International Nuclear Information System (INIS)

    Ogawa, T.

    2001-01-01

    Japan has responded to IAEA requirements on reinforced safeguard regulations. The IAEA additional protocol entered in force in Japan on December 1999. Japan submitted a preliminary information report to IAEA on June 2000 after joint works with the Nuclear Material Control Center (NMCC) of Japan. The first annual report was submitted to IAEA on May 2001. Another activity for the additional protocol is complementary accesses. The total 36 accesses to facilities have been done from November 2000 to September 2001. Procedures of access to managements are under discussion. MEXT (Ministry of Education, Culture, Sports, Science and Technology) has been constructing the Rokkasho Safeguards On-Site Laboratory from 1997, and the Rokkasho Safeguards Center from 2000. The Design Information Verification (DIV) is now ongoing. Much more personal resources will be needed for future inspections. Therefore, the budget for safeguards is increasing in contrast to the flat base budget for the total atomic energy. As for future activity, a MOX (Mixed Oxide Fuels) fuel processing plant is one of the issues for discussion. The construction of the MOX processing plant is supposed to begin on around 2004. The conclusion of additional protocol will be given by IAEA until end of 2002. Shift to integrated safeguards are under discussions by MEXT, NMCC and utilities of Japan parallel with IAEA. Key issues of discussion are cost saving for safeguards, development of personal resources for inspectors and the role of NMCC. (Y. Tanaka)

  13. Japan/India. Towards a nuclear cooperation?

    International Nuclear Information System (INIS)

    Pajon, Celine

    2011-10-01

    As diplomatic, economic and strategic relationships between Japan and India have been intensively developed for a decade, the author aims at discussing the very sensitive approach to a nuclear cooperation between these two countries as Japan, while taking benefit of the American nuclear umbrella, is a strong defender of nuclear disarmament and non proliferation, and India has been developing its own civilian and military nuclear programme outside of the international regime which it considers as discriminative. The author first discusses factors which incited Japan to build up a strategic partnership with India in front of the evolution of the political context, of the powerful upswing of China, and of the new American orientation with respect to Delhi. She comments the economic and political stakes of the currently negotiated Japan-India nuclear cooperation agreement which not only concerns the relationships between these both countries, but also French and American industrial groups which are present on the Indian market. She also notices that the Fukushima accident which has put Japan energy choices into question again, is a new deal which is to be taken into account

  14. A pilot study of a metronomic chemotherapy regimen with weekly low-dose docetaxel for previously treated non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Yokoi T

    2012-05-01

    Full Text Available Takashi Yokoi, Takeshi Tamaki, Toshiki Shimizu, Shosaku NomuraFirst Department of Internal Medicine, Kansai Medical University, Moriguchi City, Osaka, JapanBackground: Low-dose metronomic (LDM chemotherapy is a novel approach that involves frequent administration of a low dose of chemotherapeutic agent without a long interval.Purpose: The aim of this clinical pilot study was to evaluate the toxicity and efficacy of LDM chemotherapy with weekly low-dose docetaxel for previously treated non-small cell lung cancer (NSCLC.Patients and methods: The enrolled patients received 15 mg/m2 of docetaxel intravenously on a weekly basis without any interval.Results: Twenty-seven patients were enrolled in the study; 20 were men, and seven were women. The median age was 62 years (range: 32–75. Eleven patients were stage IIIB, and 16 were stage IV. The Eastern Cooperative Oncology Group performance status was 0 or 1. There was no severe hematological adverse effect; importantly, there was no neutropenia or thrombocytopenia. The objective response rate was 7.4% and the disease control rate was 51.9%. The median survival time was 16.4 months (95% CI: 5.7–36.4.Conclusion: Our preliminary results indicate that our metronomic regimen was well tolerated and active in patients with previously treated NSCLC. Thus, further investigation of this LDM regimen is warranted.Keywords: optimal biological dose, metronomic chemotherapy, docetaxel

  15. The great East Japan earthquake

    Energy Technology Data Exchange (ETDEWEB)

    Fluke, R.

    2011-06-15

    'Full text:' More formally called the Tohoku-Chihou-Taiheiyo-Oki Earthquake of March 11, 2011, it was the ensuing tsunami that caused the most death and destruction to the north-east coastal region of Japan. It is also what caused the multiple meltdowns at Fukushima Dai-ichi. Reactor Unit 1, ironically, was scheduled to be permanently shut down for decommissioning just two weeks later. The Fukushima Dai-ichi nuclear power plant has a tsunami protection barrier designed for the worst recorded tsunami in that area since 1896 - to a height of 5.7 m. The plant itself is on an elevated grade of about 10 m. The tsunami, reported to be 14-15 m, caused inundation of the entire site with at least four metres of seawater. The seawater flooded the turbine building and damaged electrical equipment including the emergency diesel generators, leaving the entire six-unit nuclear power plan without any source of AC power, known as the 'station blackout scenario'. There are numerous reports available on-line at various sites. The Japanese Government report is frank and forthcoming on the causes and the lessons learned, and the lAEA Mission report is in-depth and well presented, not only as a factual account of the events but as a unified source of the conclusions and lessons learned. Photos of the catastrophe are available at the TEPCO web site: http://www.tepco.co.jp/en/index-e.html. In this edition of the Bulletin there is a 'layman's' description of CANDU and BWR design in terms of the fundamental safety principles - Control, Cool and Contain as well as a description of how these principles were met, or not met at Fukushima Dai-ichi. Also, an excerpt from the IAEA Expert Mission is included. We 'technocrats' sometimes forget about the human aspects of a nuclear disaster. An essay by Dr. Michael Edwards is included entitled 'Psychology, Philosophy and Nuclear Science'. Other references to the events appear throughout this

  16. The great East Japan earthquake

    International Nuclear Information System (INIS)

    Fluke, R.

    2011-01-01

    'Full text:' More formally called the Tohoku-Chihou-Taiheiyo-Oki Earthquake of March 11, 2011, it was the ensuing tsunami that caused the most death and destruction to the north-east coastal region of Japan. It is also what caused the multiple meltdowns at Fukushima Dai-ichi. Reactor Unit 1, ironically, was scheduled to be permanently shut down for decommissioning just two weeks later. The Fukushima Dai-ichi nuclear power plant has a tsunami protection barrier designed for the worst recorded tsunami in that area since 1896 - to a height of 5.7 m. The plant itself is on an elevated grade of about 10 m. The tsunami, reported to be 14-15 m, caused inundation of the entire site with at least four metres of seawater. The seawater flooded the turbine building and damaged electrical equipment including the emergency diesel generators, leaving the entire six-unit nuclear power plan without any source of AC power, known as the 'station blackout scenario'. There are numerous reports available on-line at various sites. The Japanese Government report is frank and forthcoming on the causes and the lessons learned, and the lAEA Mission report is in-depth and well presented, not only as a factual account of the events but as a unified source of the conclusions and lessons learned. Photos of the catastrophe are available at the TEPCO web site: http://www.tepco.co.jp/en/index-e.html. In this edition of the Bulletin there is a 'layman's' description of CANDU and BWR design in terms of the fundamental safety principles - Control, Cool and Contain as well as a description of how these principles were met, or not met at Fukushima Dai-ichi. Also, an excerpt from the IAEA Expert Mission is included. We 'technocrats' sometimes forget about the human aspects of a nuclear disaster. An essay by Dr. Michael Edwards is included entitled 'Psychology, Philosophy and Nuclear Science'. Other references to the events appear throughout this edition.(author)

  17. Germ cell tumors of testis; an update in chemotherapy treatment

    International Nuclear Information System (INIS)

    Parvez, T.

    2002-01-01

    Prior to the use of cisplatin, durable complete remission of metastatic testicular cancer were rare. In 1977, a chemotherapy treatment program including cisplatin, vinblastine, and bleomycin (PVB) let to high response rates and acceptable toxicity in patients with disseminated testicular cancer. After that, bleomycin, etoposide, and cisplatin (BEP) chemotherapy regimen was established as a standard therapy for good- and poor-risk disease and further, ifosfamide-based regimens or high-dose chemotherapy with stem cell rescue as the salvage therapy. The results of these prospective, randomized clinical trials that have markedly improved the outlook of patients with this type of cancer have been reviewed in this article. While the present state-of-the-art treatment for metastatic testicular cancer is promising approximately one-third of patients with poor risk disease will not achieve a remission. Trials of new agents and approaches are needed to increase the patient survival. (author)

  18. Hyperfractionated radiotherapy with simultaneous chemotherapy in Ewing's sarcoma

    International Nuclear Information System (INIS)

    Dunst, J.; Sauer, R.; Burgers, J.M.V.; Hawlicek, R.; Trott, K.R.; Juergens, H.

    1988-01-01

    In 1981, the German Society of Pediatric Oncology initiated a multi-institutional study for the treatment of Ewing's sarcoma. The protocol (Cooperative Ewing's Sarcoma Study, CESS 81) consisted of four courses of a four-drug-regimen (VACA), each course taking nine weeks. Local therapy (radical surgery or resection plus irradiation or radiotherapy alone) was performed after the second course. The results of CESS 81 can be summarized as follows: VACA-chemotherapy is effective in controlling systemic disease. Initial tumor mass and response to initial chemotherapy are of major prognostic value for local control and survival. Permanent local control is a problem, especially in irradiated patients. The high local failure rate in irradiated patients in CESS 81 could be attributable to the following reasons: Late start of local therapy (after 18 weeks of chemotherapy), uneven distribution of prognostic parameters: Large tumors were more often irradiated than operated, protocol deviations in irradiated patients. (orig.)

  19. Quality of life assessment in dogs and cats receiving chemotherapy

    DEFF Research Database (Denmark)

    Vøls, Kåre Kryger; Heden, Martin Anker; Kristensen, Annemarie Thuri

    2017-01-01

    comparative analysis of published papers on the effects of chemotherapy on QoL in dogs and cats were conducted. This was supplemented with a comparison of the parameters and domains used in veterinary QoL-assessments with those used in the Pediatric Quality of Life Inventory (PedsQL™) questionnaire designed...... to assess QoL in toddlers. Each of the identified publications including QoL-assessment in dogs and cats receiving chemotherapy applied a different method of QoL-assessment. In addition, the veterinary QoL-assessments were mainly focused on physical clinical parameters, whereas the emotional (6/11), social...... (4/11) and role (4/11) domains were less represented. QoL-assessment of cats and dogs receiving chemotherapy is in its infancy. The most commonly reported method to assess QoL was questionnaire based and mostly included physical and clinical parameters. Standardizing and including a complete range...

  20. Evaluation of host quality of life and immune function in breast cancer patients treated with combination of adjuvant chemotherapy and oral administration of Lentinula edodes mycelia extract

    Directory of Open Access Journals (Sweden)

    Nagashima Y

    2013-07-01

    Full Text Available Yukiko Nagashima,1 Noriko Maeda,2 Shigeru Yamamoto,2 Shigefumi Yoshino,2 Masaaki Oka21Department of Breast and Thyroid Surgery, Shakaihoken Shimonoseki Kosei Hospital, Shimonoseki City, Yamaguchi, Japan; 2Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, JapanPurpose: Anthracycline-based chemotherapies for breast cancer are well known to have adverse effects and can also negatively affect host immune function. There is therefore a necessity for an adjuvant that maintains the quality of life (QOL and immune function of cancer patients receiving anthracycline-based chemotherapies.Patients and methods: The present study investigated the effectiveness of the concomitant use of Lentinula edodes mycelia extract (LEM, an oral immunomodulator, with FEC75 (5-fluorouracil + epirubicin + cyclophosphamide therapy on host QOL and immune function in breast cancer patients with nodal metastases. Ten breast cancer patients with nodal metastases receiving surgery were enrolled in this study. Treatment with 5-fluorouracil (500 mg/m2, epirubicin (75 mg/m2, and cyclophosphamide (500 mg/m2 was performed every 21 days for two courses, and LEM (1800 mg/day by mouth was administered during the second course.Results: In the first course, hematological toxicity was observed and host QOL and immune function were exacerbated. In the second course, however, the number of white blood cells and lymphocytes did not decrease and host QOL was maintained. Furthermore, the cytotoxic activities of natural killer (NK and lymphokine-activated killer cells and the proportion of activated NK and NK T-cells in lymphocytes were maintained in the second course.Conclusion: It has been suggested that the concomitant use of LEM with FEC75 therapy can maintain host QOL and immune function, and offer important implications for an application of LEM as a useful oral adjuvant to anthracycline-based chemotherapies

  1. Neoadjuvant chemotherapy with cisplatin and methotrexate in patients with muscle-invasive bladder tumours

    DEFF Research Database (Denmark)

    Sengeløv, Lisa; von der Maase, Hans; Lundbeck, Finn

    2002-01-01

    This prospective, randomized study based on two associated trials was designed to evaluate the effect of neoadjuvant chemotherapy with cisplatin and methotrexate with folinic acid rescue or no chemotherapy prior to local treatment in patients with T2-T4b, NX-3, MO transitional cell carcinoma.......2 months in the group receiving chemotherapy and 16.3 in the group not receiving chemotherapy. The 5-year survival rate was 19% in the group receiving chemotherapy and 24% in the groups not receiving chemotherapy (p = 0.98). Late toxicity grade 3 or 4 of the bladder was recorded in 25% of the patients...

  2. COLONIC DIVERTICULITIS IN CHEMOTHERAPY PATIENTS: SHOULD OPERATIVE INDICATIONS CHANGE?

    Science.gov (United States)

    Samdani, Tushar; Pieracci, Fredric M.; Eachempati, Soumitra R.; Benarroch-Gampel, Jaime; Weiss, Alex; Pietanza, M. Cathy; Barie, Philip S.; Nash, Garrett M.

    2015-01-01

    Introduction Management of the immunosuppressed patient with diverticular disease remains controversial. We report the largest series of colon cancer patients undergoing chemotherapy and hospitalized for acute diverticulitis, to determine whether recent treatment with systemic chemotherapy is associated with increased risk for/increased severity of recurrent diverticulitis. Methods Retrospective cohort study of adult patients hospitalized for an initial episode of acute colonic diverticulitis at Memorial Sloan Kettering Cancer Center, 1988–2004. Outcomes in patients receiving systemic chemotherapy within one month of admission for diverticulitis (“Chemo”) were compared to outcomes of patients not receiving chemotherapy within the past month (“No-chemo”). Results A total 131 patients met inclusion criteria. Chemo patients did not differ significantly from No-chemo group in terms of severity of acute diverticulitis at index admission (13.2% vs. 4.4%, respectively, p=0.12), resumption of chemotherapy (median 2 months), failure of non-operative management (13.2% vs 4.4%, respectively, p=0.12), frequency of recurrence (20.5% vs 18.55), hospital length of stay (p=0.08), and likelihood of interval resection (24.0% vs. 16.2%, respectively, p=0.39). Chemo patients recurred with more severe disease, were more likely to undergo emergent surgery (75.0% vs. 23.5%, respectively, p=0.03), and were more likely to be diverted (100.0% vs. 25.0%, respectively, p=0.03). Chemo patients were significantly more likely to incur a postoperative complication (100% vs 9.1% p diverticulitis in patients receiving chemotherapy. Nonoperative management in the acute or interval setting appears preferable whenever possible. PMID:25448673

  3. Post-chemotherapy arthralgia and arthritis in lung cancer

    Directory of Open Access Journals (Sweden)

    Aref H Amiri

    2012-01-01

    Full Text Available Objective: Evaluate the characteristics of arthritis, arthralgia and musculoskeletal pain after chemotherapy in patients with lung cancer. Materials and Methods: In this study, we evaluate the characteristics of 17 patients with joint symptoms following receiving chemotherapy for lung cancer. Demographic information of patients including sex, age, time of rheumatologic findings after starting of chemotherapy, time of improvement after starting of medication, and relevant laboratory findings for each patient. Results: A total of seventeen patients (six women with mean age 41.2 ± 5.2 years and 11 men with mean age 42.5 ± 8.2 that received standard chemotherapy for lung cancer according to stage of disease. Joint symptoms usually began about seven months after the first session of chemotherapy. Patients had an average of two tender joints and 1 hr of morning stiffness. Four patients were positive for anti-nuclear antibody, and none of patient was positive for rheumatoid factor. Non-steroidal anti-inflammatory drugs, disease modifying anti-rheumatic drugs (DMARD, corticosteroids, and venlafaxine were prescribed. Four patients did not show an improvement. Follow-up was available for all patients. 11 patients showed favorable responses, characterized by a significant decrease (more than 50% in morning stiffness, pain, and tender joint counts after a mean of three months′ treatment. Two patients had complete resolution of symptoms and did not required further medications for arthritis, arthralgia or musculoskeletal pain. Conclusion: Chemotherapy-related arthropathy in lung cancer is not uncommon. Early treatment with NSAID, DMARD, and corticosteroids is effective in the majority of patients.

  4. Cis-platinum chemotherapy for ocular basal cell carcinoma.

    OpenAIRE

    Morley, M.; Finger, P. T.; Perlin, M.; Weiselberg, L. R.; DeBlasio, D. S.

    1991-01-01

    We have used intravenous cis-platinum chemotherapy in the treatment of three patients with basal cell carcinoma of the lid extending into the orbit. Cis-platinum chemotherapy caused a reduction in tumour size and thereby delayed surgery in all cases. It allowed for local resection in one case, appeared to delay a patient's exenteration in a second case, and was used prior to radiotherapy in a third case. While not curative, cis-platinum may be useful as an adjuvant to decrease tumour mass pri...

  5. A theoretical quantitative model for evolution of cancer chemotherapy resistance

    Directory of Open Access Journals (Sweden)

    Gatenby Robert A

    2010-04-01

    Full Text Available Abstract Background Disseminated cancer remains a nearly uniformly fatal disease. While a number of effective chemotherapies are available, tumors inevitably evolve resistance to these drugs ultimately resulting in treatment failure and cancer progression. Causes for chemotherapy failure in cancer treatment reside in multiple levels: poor vascularization, hypoxia, intratumoral high interstitial fluid pressure, and phenotypic resistance to drug-induced toxicity through upregulated xenobiotic metabolism or DNA repair mechanisms and silencing of apoptotic pathways. We propose that in order to understand the evolutionary dynamics that allow tumors to develop chemoresistance, a comprehensive quantitative model must be used to describe the interactions of cell resistance mechanisms and tumor microenvironment during chemotherapy. Ultimately, the purpose of this model is to identify the best strategies to treat different types of tumor (tumor microenvironment, genetic/phenotypic tumor heterogeneity, tumor growth rate, etc.. We predict that the most promising strategies are those that are both cytotoxic and apply a selective pressure for a phenotype that is less fit than that of the original cancer population. This strategy, known as double bind, is different from the selection process imposed by standard chemotherapy, which tends to produce a resistant population that simply upregulates xenobiotic metabolism. In order to achieve this goal we propose to simulate different tumor progression and therapy strategies (chemotherapy and glucose restriction targeting stabilization of tumor size and minimization of chemoresistance. Results This work confirms the prediction of previous mathematical models and simulations that suggested that administration of chemotherapy with the goal of tumor stabilization instead of eradication would yield better results (longer subject survival than the use of maximum tolerated doses. Our simulations also indicate that the

  6. Perioperative chemotherapy and hepatic resection for resectable colorectal liver metastases

    Science.gov (United States)

    Sakamoto, Yasuo; Hayashi, Hiromitsu; Baba, Hideo

    2015-01-01

    The role of perioperative chemotherapy in the management of initially resectable colorectal liver metastases (CRLM) is still unclear. The EPOC trial [the European Organization for Research and Treatment of Cancer (EORTC) 40983] is an important study that declares perioperative chemotherapy as the standard of care for patients with resectable CRLM, and the strategy is widely accepted in western countries. Compared with surgery alone, perioperative FOLFOX therapy significantly increased progression-free survival (PFS) in eligible patients or those with resected CRLM. Overall survival (OS) data from the EPOC trial were recently published in The Lancet Oncology, 2013. Here, we discussed the findings and recommendations from the EORTC 40983 trial. PMID:25713806

  7. Laryngeal necrosis after combined chemotherapy and radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Miyaguchi, Mamoru; Kubo, Takeshi [Osaka Univ., Suita (Japan). School of Medicine; Takashima, Hitoshi [Kagawa Medical School (Japan)

    1997-08-01

    Post-radiation necrosis of the larynx is a major complication after irradiation and has become rare. Recently, combined chemotherapy and radiation therapy has been introduced for head and neck tumours. The authors report a case of laryngeal necrosis after combination therapy for a patient with cervical lymph node metastases of nasopharyngeal carcinoma and review the literature on late laryngeal necrosis. Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence. (author).

  8. Current trends in rehabilitation engineering in Japan.

    Science.gov (United States)

    Ohnabe, Hisaichi

    2006-01-01

    In 2005, the elderly generation comprised 20% of the Japanese population. This percentage will grow to approximately 30% in 2030, meaning that nearly one in three people in Japan will be 65 years of age or older. Japan is the first nation in the world to face this situation. This article uses the context of Japanese society to give an overview of the elderly and people with disabilities; the International Classification of Functioning, Disability, and Health model; rehabilitation engineering-related policy; and education. In addition, we examine how governmental programs and Japanese law regarding technical aids may evolve by 2030. Partner robots, intelligent powered wheelchairs, nursing robots, and other technologies are introduced as examples of rehabilitation engineering and assistive technology. We also discuss the volunteer activities of the Rehabilitation Engineering Society of Japan (RESJA) in response to the Asian tsunami disaster and the achievements of a group of students from a Japanese senior high school of industry.

  9. L-Band RFI in Japan

    Science.gov (United States)

    Soldo, Yan; de Matthaeis, Paolo; Le Vine, David M.

    2016-01-01

    In recent years, three instruments have been launched into orbit with the aim of producing global maps of sea surface salinity and soil moisture using the 1400-1427 MHz band: SMOS, Aquarius and SMAP. Although this frequency band is allocated to passive measurements only, RFI (Radio-Frequency Interference) is present in the data of all three missions. On a global scale, the three sensors have observed approximately the same distribution of RFI. Japan is an important exception that has implications for the design of RFI detection algorithms. RFI in Japan is caused by a large number of emitters belonging to the same system (TV receivers) and for this reason some traditional RFI detection strategies detect little to no RFI over Japan. The study of this case has led to an improvement of the approach to detect RFI in Aquarius data.

  10. The Arctic policy of China and Japan

    DEFF Research Database (Denmark)

    Tonami, Aki

    2014-01-01

    crucial point from the traditional security perspective, but more from the viewpoint of economic security and development. In addition, their perspectives manifest themselves slightly differently from one another. China is willing to invest more in the Arctic. Japan is willing to build on the achievements......At the May 2013 Arctic Council Ministerial Meeting, five Asian states, namely China, Japan, India, Singapore and South Korea, were accepted to become new Permanent Observers at the Arctic Council. Nonetheless, little attention has been paid to the Asian states and their interest in the Arctic. Most...... discussions have focused on China and the assessment of China’s interest in the Arctic is divided. This paper attempts to fill this gap by presenting and comparing the various components of the Arctic policies of China and Japan. Referring to Putnam’s model of the “two-level game” and Young’s categorization...

  11. [Intraaortic balloon pumping( IABP) in Japan].

    Science.gov (United States)

    Ono, Tomoyuki; Tanoue, Yoshihisa; Tominaga, Ryuji

    2014-07-01

    The intraaortic balloon pumping (IABP) is the most widely used circulatory assist device. IABP increases coronary perfusion in diastolic phase by the inflation of the balloon in the descending aorta (diastolic augmentation) and reduces afterload in systolic phase by the deflation of the balloon( systolic unloading). IABP improves the hemodynamic condition of patients who fall into acute heart failure and/or cardiogenic shock. Six-type IABP system can be used in Japan. The IABP-SHOCK II trial shows that there is no significant difference in mortality between optimal medical treatment with IABP and without IABP in addition to early revascularization. Clinical backgrounds in Japan are different from those in IABP-SHOCK II trial, and the further prospective studies of IABP in Japan thus called for.

  12. Insights into software development in Japan

    Science.gov (United States)

    Duvall, Lorraine M.

    1992-01-01

    The interdependence of the U.S.-Japanese economies makes it imperative that we in the United States understand how business and technology developments take place in Japan. We can gain insight into these developments in software engineering by studying the context in which Japanese software is developed, the practices that are used, the problems encountered, the setting surrounding these problems, and the resolution of these problems. Context includes the technological and sociological characteristics of the software development environment, the software processes applied, personnel involved in the development process, and the corporate and social culture surrounding the development. Presented in this paper is a summary of results of a study that addresses these issues. Data for this study was collected during a three month visit to Japan where the author interviewed 20 software managers representing nine companies involved in developing software in Japan. These data are compared to similar data from the United States in which 12 managers from five companies were interviewed.

  13. Epidemic of charcoal burning suicide in Japan.

    Science.gov (United States)

    Yoshioka, Eiji; Hanley, Sharon J B; Kawanishi, Yasuyuki; Saijo, Yasuaki

    2014-01-01

    The charcoal burning suicide epidemics in both Hong Kong and Taiwan have been well documented. However, little is known about the situation in Japan. To examine the impact of charcoal burning suicide on the overall and other method-specific suicide rates between 1998 and 2007 in Japan. Using data obtained from the Vital Statistics of Japan, negative binomial regression analyses were performed to investigate the impact of the charcoal burning method. In males and females aged 15-24 and 25-44 years, the charcoal burning epidemic led to a substantial increase in overall suicides, without a decrease in other methods. In all other age groups, no such trend was observed. In young Japanese, the charcoal burning method may have appealed to individuals who might not have chosen other highly or relatively lethal methods, and consequently led to an increase in overall suicides.

  14. Japan's Ambivalent Diplomacy on Climate Change

    International Nuclear Information System (INIS)

    Pajon, C.

    2010-01-01

    Japan often pictures itself as an environmental leader. While many examples of Japan's actions against climate change are in line with global climate change norms, others can be in opposition to them. This study, based on first hand interviews with Japanese policy makers and actors from the private and civil society sector, gives an informed perspective on the process through which Japan came to integrate and implement, at the domestic level, the international objective of climate change prevention, pointing out the discrepancies, tensions or synergies that emerged. As the current governance on climate change, and particularly after the Copenhagen conference, tends to reassert the importance of the national level against the global one, the Japanese case can serve as an example of tools and strategies that fully integrate the domestic level

  15. Introduction of nuclear medicine research in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Inubushi, Masayuki [Kawasaki Medical School, Division of Nuclear Medicine, Department of Radiology, Kurashiki, Okayama (Japan); Higashi, Tatsuya [National Institutes of Quantum and Radiological Science and Technology, National Institute of Radiological Sciences, Chiba, Chiba (Japan); Kuji, Ichiei [Saitama Medical University International Medical Center, Department of Nuclear Medicine, Hidaka-shi, Saitama (Japan); Sakamoto, Setsu [Dokkyo University School of Medicine, PET Center, Mibu, Tochigi (Japan); Tashiro, Manabu [Tohoku University, Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Sendai, Miyagi (Japan); Momose, Mitsuru [Tokyo Women' s Medical University, Department of Diagnostic Imaging and Nuclear Medicine, Tokyo (Japan)

    2016-12-15

    There were many interesting presentations of unique studies at the Annual Meeting of the Japanese Society of Nuclear Medicine, although there were fewer attendees from Europe than expected. These presentations included research on diseases that are more frequent in Japan and Asia than in Europe, synthesis of original radiopharmaceuticals, and development of imaging devices and methods with novel ideas especially by Japanese manufacturers. In this review, we introduce recent nuclear medicine research conducted in Japan in the five categories of Oncology, Neurology, Cardiology, Radiopharmaceuticals and Technology. It is our hope that this article will encourage the participation of researchers from all over the world, in particular from Europe, in scientific meetings on nuclear medicine held in Japan. (orig.)

  16. Introduction of nuclear medicine research in Japan.

    Science.gov (United States)

    Inubushi, Masayuki; Higashi, Tatsuya; Kuji, Ichiei; Sakamoto, Setsu; Tashiro, Manabu; Momose, Mitsuru

    2016-12-01

    There were many interesting presentations of unique studies at the Annual Meeting of the Japanese Society of Nuclear Medicine, although there were fewer attendees from Europe than expected. These presentations included research on diseases that are more frequent in Japan and Asia than in Europe, synthesis of original radiopharmaceuticals, and development of imaging devices and methods with novel ideas especially by Japanese manufacturers. In this review, we introduce recent nuclear medicine research conducted in Japan in the five categories of Oncology, Neurology, Cardiology, Radiopharmaceuticals and Technology. It is our hope that this article will encourage the participation of researchers from all over the world, in particular from Europe, in scientific meetings on nuclear medicine held in Japan.

  17. Evaluation of the field application of PCR in the eradication of contagious equine metritis from Japan.

    Science.gov (United States)

    Anzai, Toru; Wada, Ruichi; Okuda, Toshio; Aoki, Toshihisa

    2002-11-01

    The effectiveness of the polymerase chain reaction (PCR) as a field application test for the eradication of contagious equine metritis (CEM) was evaluated. Seven-thousands five-hundred and thirty-four genital swabs were collected from 4,026 Thoroughbred broodmares and stallions in Japan to test "high risk" horses as well as for general surveillance testing from 1998 to 2001. Bacterial isolation as well as PCR testing of original specimens and cultured specimens was performed for detection of Taylorella equigenitalis from genital swabs. As a result, T. equigenitalis was detected in 12 mares and 1 stallion by PCR, although the bacteria were isolated from only 2 of the PCR-positive mares. CEM-infected and carrier horses were treated by a combination of chemotherapy and surgery. Subsequent follow-up testing over a 3-year period did not detect T. equigenitalis. It was demonstrated that PCR testing was more sensitive than isolation as a method for the detection of T. equigenitalis from genital swabs of horses in the field. It was therefore suggested that a combination of PCR testing and treatment were useful measures in the eradication of CEM from Japan.

  18. Molecular epidemiology, antimicrobial susceptibility, and characterization of macrolide-resistant Streptococcus pyogenes in Japan.

    Science.gov (United States)

    Tanaka, Yuhei; Gotoh, Kenji; Teramachi, Mariko; Ishimoto, Kazuhisa; Tsumura, Naoki; Shindou, Shizuo; Yamashita, Yushiro

    2016-11-01

    Here we report the molecular epidemiology of macrolide-resistant Streptococcus pyogenes (group A streptococci, GAS) isolated from children with pharyngotonsillitis between 2011 and 2013 in Japan. In 299 isolates, 124 (41.5%) isolates were macrolide-resistant. We characterized the isolates by emm typing, multilocus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE). Of 299 isolates, 124 (41.5%) were macrolide-resistant isolates, 76 (61.3%) possessed mefA and 46 (37.1%) possessed ermB. All 76 isolates with mefA possessed msrD. There were no isolates possessed ermTR in this study. Eight emm/MLST types were observed. The predominant type was emm1/ST28 (57 isolates, 46.0%), which possessed the mefA/msrD complex, presenting as the M phenotype. The second most predominant type was emm12/ST467, which possessed ermB, presenting as the cMLS B phenotype. Of the cMLS B phenotype isolates, types emm28/ST52 and emm12/ST36 had multiple genetic backgrounds. We found high proportions of macrolide-resistant GAS in the southwestern areas of Japan. Copyright © 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  19. Utilization and evaluation of noncore chemotherapy regimens within an academic medical center.

    Science.gov (United States)

    Jared, Jason R; Mably, Mary S; Makielski, Rory; Reed, Michael P; Fallon, Michael J; Liu, Glenn; Mulkerin, Daniel; Callander, Natalie S

    2017-10-01

    Uniformity of evidence-based chemotherapy prescribing using approved, standard, or "core" regimens provides systems-based safety. Noncore chemotherapy regimens are non-standard-of-care regimens requested by physicians on a patient-by-patient basis. Chemotherapy Council, a Pharmacy & Therapeutics subcommittee, assesses all requests and determines approval status based upon submitted evidence and patient-specific factors. This study's purpose is to describe noncore chemotherapy regimens utilization, efficacy, and clinical outcomes in patients receiving noncore chemotherapy regimens. This retrospective chart review includes a two-stage utilization and outcomes evaluation of patients receiving noncore chemotherapy regimens. Stage I, a demographics and utilization assessment of patients receiving noncore chemotherapy regimens, has data collection including patient age, sex, performance score, malignancy, and noncore chemotherapy regimen use justification. Stage II assesses noncore chemotherapy regimen-related, patient-specific outcomes of breast cancer noncore chemotherapy regimen patients. Breast cancer patients were evaluated on regimen and clinical outcomes including disease stage, regimen duration, discontinuation reason, subsequent chemotherapy, survival, and time from noncore chemotherapy regimen until death. Within stage I, 307 patient-specific noncore chemotherapy regimen requests were submitted. The most commonly submitted rationale was modification of a core regimen (33%), followed by patient-specific factors (29%) and salvage therapy (22%). For stage II, 29 breast cancer patients received a noncore chemotherapy regimen and most (54%) received a modified core regimen. The vast majority of noncore chemotherapy regimen discontinuation was due to either regimen completion (42%) or disease progression (42%). Nonelective hospitalizations (35%) and mortality (30%) were found during the median 13.3 months of follow up. Noncore chemotherapy regimen use provides

  20. Human rights in Japan: progress and challenges

    Directory of Open Access Journals (Sweden)

    Yolanda Muñoz González

    2007-11-01

    Full Text Available The aim of this paper is to present an overview of the improvements and challenges that Japan has been facing between 1983 and 2007. The paper explores the interaction among the different stakeholders –i.e. the Japanese Government, international organizations and civil society- to advance full access to citizenship regarding gender equality, the elimination of social and physical barriers for the inclusion of people with disabilities and elderly persons; ethnic minorities –specifically the situation of the Ainu people and the Buraku community – and the persons considered as “foreigners” living in Japan.