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Sample records for chemical defense program

  1. Department of Defense Chemical and Biological Defense Program. Volume 2: FY2002-2004 Performance Plan

    Science.gov (United States)

    2003-04-01

    Complete research studies for the development of vaccine candidates for WEE virus. Defense Advanced Research Projects Agency (DARPA) Program...encephalitic alphaviruses. Continue research for the development of vaccine candidates for EEE virus infection. Test promising vaccine candidates for

  2. Department of Defense Chemical, Biological, Radiological, and Nuclear Defense Program, Annual Report to Congress, 2004

    Science.gov (United States)

    2004-05-01

    Strain Rsa493 Bacillus cereus Completed (4/2003) Strain Atcc 14579 Franciscella tularensis Completed (10/2003) Unpublished Burkholderia mallei...was demonstrated to protect CBRN Defense Requirements and Programs 63 higher animal models from fever and bacteremia following a conjunctival dose... Bacillus anthracis), description of the vaccine, explanation of U.S. DoD policies regarding biological defense vaccines, U.S. DoD policies regarding

  3. Department of Defense Chemical and Biological Defense Programs. Annual Report to Congress 2007

    Science.gov (United States)

    2007-04-01

    challenges. (see Figure 1.) The program depends on support in three priority areas: (1) Stable funding for the Transformational Medical Technolgies ...defense, speed of mass (life and mobility ) and information, fiscal barriers, values, and attitudes. The principles of jointness and developing an...Battlefield anti-intrusion Detection System (BaiS) an/PrS9 (Fue 2QFY06) 13. mobile Detection assessment response System (mDarS) (1QFY07) 14. Joint

  4. Chemical and Biological Defense Program Annual Report to Congress

    Science.gov (United States)

    2006-03-01

    state public health systems, to expand existing biosurveillance efforts, and to fund research on medical countermeasures against potential bioterror...Detection System (JBSDS) • Joint Portal Shield • Biological Identification System (BIDS) • Dry Filter Units (DFUs) Table 2-3 Biological Defense...Detection System (BIDS) • Joint Portal Shield Network Sensor System • Automated biological remote detection and early warning capabilities

  5. Collaborative Core Research Program for Chemical-Biological Warfare Defense

    Science.gov (United States)

    2015-01-04

    Research Center (UC-DDRC, part of UC-MDI). Using an EvoTec robot , single point (10 μM final solution test chemical concentration) 2 measurements...assay on neuroblastoma cell lines. We performed this method, as well as incorporated a novel method developed at US Army Medical Research Institute of...formulations chemists to determine the optimal dose methods. These new CWA countermeasures will be transitioned to the Chemical Biological Medical Systems for

  6. Department of Defense Chemical and Biological Defense Program. Volume 1: Annual Report to Congress

    Science.gov (United States)

    2003-04-01

    Program Annual Report E-46 • Cloned and sequenced regions of the polymerase gene (E9L) from 35 variola isolates, as well as cidofovir -resistant...IC50) of cidofovir and 3-hexadecyloxy-1- propanol (HDP)- cidofovir against 40 strains of variola, monkeypox, cowpox, and vaccinia. All viruses... cidofovir in vitro against a panel of orthopoxviruses at USAMRIID and variola at the Centers for Disease Control and Prevention (CDC). Determined that

  7. Joint Program Executive Office for Chemical and Biological Defense Strategic Plan FY13-18

    Science.gov (United States)

    2012-06-01

    strategy calls for a global Biosurveillance network for timely disease surveillance of biological pathogens whether intentionally made or naturally... Biosurveillance . The President and Secretary of Defense provided renewed emphasis on rapidly and efficiently developing and manufacturing effective medical... Biosurveillance . Our ability to obtain early warning about the deliberate use or natural emergence of dangerous pathogens hinges upon the

  8. DEFENSE PROGRAMS RISK MANAGEMENT FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Constantin PREDA

    2012-01-01

    Full Text Available For the past years defense programs have faced delays in delivering defense capabilities and budget overruns. Stakeholders are looking for ways to improve program management and the decision making process given the very fluid and uncertain economic and political environment. Consequently, they have increasingly resorted to risk management as the main management tool for achieving defense programs objectives and for delivering the defense capabilities strongly needed for the soldiers on the ground on time and within limited defense budgets. Following a risk management based decision-making approach the stakeholders are expected not only to protect program objectives against a wide range of risks but, at the same time, to take advantage of the opportunities to increase the likelihood of program success. The prerequisite for making risk management the main tool for achieving defense programs objectives is the design and implementation of a strong risk management framework as a foundation providing an efficient and effective application of the best risk management practices. The aim of this paper is to examine the risk management framework for defense programs based on the ISO 31000:2009 standard, best risk management practices and the defense programs’ needs and particularities. For the purposes of this article, the term of defense programs refers to joint defense programs.

  9. A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program

    Science.gov (United States)

    2005-03-01

    8 2.7 Sinorhizobium meliloti Toxicity Test-New Mexico State University (Las Cruces, N M...problems. NRL continues to analyze chemicals and data will be added as it becomes available. 2.7 Sinorhizobium meliloti Toxicity Test-New Mexico State...University (Las Cruces, NM) This test uses the bacterium Sinorhizobium meliloti , a bacterium that readily reduces a tetrazolium dye. The dye is normally

  10. Joint Service Chemical and Biological Defense Program FY 08-09 Overview

    Science.gov (United States)

    2007-10-01

    detoxifying component. These include photocatalysts, nanoceramic -supported enzymes, and biocides/sporocides. Researchers will also pursue technologies...oil, and lubricants (POLs)—significant capability improvements for the armor community. The JSLIST Block II Glove Upgrade (JB2GU) provides protection...Strategy, and Support PM Project manager POL petroleum, oil, and lubricants POM Program objective memorandum PPE personal protective equipment R&D

  11. Defense Meteorological Satellite Program (DMSP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Defense Meteorological Satellite Program (DMSP) satellites collect visible and infrared cloud imagery as well as monitoring the atmospheric, oceanographic,...

  12. AFRL Defensive IO Programs

    Science.gov (United States)

    2007-11-02

    Wireless Information Assurance • Steganography • Air Force Enterprise Defense (AFED) 10 Distributed Agents for Information Warfare Operational...information (images, documents, overlays, audio , links, etc.) •multi-level data release to coalition forces; key-based access •covert communication...maximize throughput of communication channels Data Hiding/Embedding Steganography Watermarking Steganalysis 14 Payoffs • Integrates existing

  13. Risk Management Programs for Defense Acquisition Systems

    Science.gov (United States)

    2007-11-02

    The audit objective was to evaluate the effectiveness of risk management programs for Defense acquisition systems. Specifically, we determined whether DoD risk management policies and procedures for Defense acquisition systems were effectively implemented and what impact risk management programs bad on reducing program risks and costs. We also reviewed management controls as they applied to the audit objectives.

  14. Defense Meteorological Satellite Program (DMSP) Film

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The United States Air Force Defense Meteorological Satellite Program (DMSP) Operational Linescan System (OLS) is a polar orbiting meteorological sensor with two...

  15. Chemical Stockpile Disposal Program

    Energy Technology Data Exchange (ETDEWEB)

    Krummel, J.R.; Policastro, A.J.; Olshansky, S.J.; McGinnis, L.D.

    1990-10-01

    As part of the Chemical Stockpile Disposal Program mandated by Public Law 99--145 (Department of Defense Authorization Act), an independent review is presented of the US Army Phase I environmental report for the disposal program at the Pine Bluff Arsenal (PBA) in Arkansas. The Phase I report addressed new and additional concerns not incorporated in the final programmatic environmental impact statement (FPEIS). Those concerns were addressed by examining site-specific data for the PBA and by recommending the scope and content of a more detailed site- specific study. This dependent review evaluates whether the new site-specific data presented in the Phase I report would alter the decision in favor of on-site disposal that was reached in the FPEIS, and whether the recommendations for the scope and content of the site-specific study are adequate. Based on the methods and assumptions presented in the FPEIS, the inclusion of more detailed site-specific data in the Phase I report does not change the decision reached in the FPEIS (which favored on-site disposal at PBA). It is recommended that alternative assumptions about meteorological conditions be considered and that site-specific data on water, ecological, socioeconomic, and cultural resources, and emergency planning and preparedness be considered explicitly in the site-specific EIS decision-making process. 13 refs., 1 fig.

  16. Chemical Stockpile Disposal Program

    Energy Technology Data Exchange (ETDEWEB)

    Krummel, J.R.; Policastro, A.J.; Olshansky, S.J.; McGinnis, L.D.

    1990-10-01

    As part of the Chemical Stockpile Disposal Program mandated by Public Law 99--145 (Department of Defense Authorization Act), an independent review is presented of the US Army Phase I environmental report for the disposal program at the Umatilla Depot Activity (UMDA) in Hermiston, Oregon. The Phase I report addressed new and additional concerns not incorporated in the final programmatic environmental impact statement (FPEIS). Those concerns were addressed by examining site-specific data for the Umatilla Depot Activity and by recommending the scope and content of a more detailed site-specific study. This independent review evaluates whether the new site-specific data presented in the Phase I report would alter the decision in favor of on-site disposal that was reached in the FPEIS, and whether the recommendations for the scope and content of the site-specific study are adequate. Based on the methods and assumptions presented in the FPEIS, the inclusion of more detailed site-specific data in the Phase I report does not change the decision reached in the FPEIS (which favored on-site disposal at UMDA). It is recommended that alternative assumptions about meteorological conditions be considered and that site-specific data on water, ecological, socioeconomic, and cultural resources; seismicity; and emergency planning and preparedness be considered explicitly in the site-specific EIS decision-making process. 7 refs., 1 fig.

  17. Marine biofilm bacteria evade eukaryotic predation by targeted chemical defense.

    Directory of Open Access Journals (Sweden)

    Carsten Matz

    Full Text Available Many plants and animals are defended from predation or herbivory by inhibitory secondary metabolites, which in the marine environment are very common among sessile organisms. Among bacteria, where there is the greatest metabolic potential, little is known about chemical defenses against bacterivorous consumers. An emerging hypothesis is that sessile bacterial communities organized as biofilms serve as bacterial refuge from predation. By testing growth and survival of two common bacterivorous nanoflagellates, we find evidence that chemically mediated resistance against protozoan predators is common among biofilm populations in a diverse set of marine bacteria. Using bioassay-guided chemical and genetic analysis, we identified one of the most effective antiprotozoal compounds as violacein, an alkaloid that we demonstrate is produced predominately within biofilm cells. Nanomolar concentrations of violacein inhibit protozoan feeding by inducing a conserved eukaryotic cell death program. Such biofilm-specific chemical defenses could contribute to the successful persistence of biofilm bacteria in various environments and provide the ecological and evolutionary context for a number of eukaryote-targeting bacterial metabolites.

  18. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2013-03-01

    Radios, Joint Land Attack Cruise Missile Defense Elevated Netter Sensor System, C-130 Avionics Modernization Program, or National Polar-orbiting...investigation of hypoxia-like physiological symptoms experienced by some F- 22A pilots, an issue identified as being significant starting in 2008 and

  19. Affordability of Defense Acquisition Programs

    Science.gov (United States)

    2015-02-01

    2 The study team constructed a representation of the Army investment program and plans through fiscal year 2030 using...shares are used to project resources available in each category through approximately 2030 . By fixing the topline at the level of the end of the...scenario development that takes place in the Analytic Agenda process. In that context, the Assessment Division (N-81) in the Office of the Chief of 31

  20. Physics of a ballistic missile defense - The chemical laser boost-phase defense

    Science.gov (United States)

    Grabbe, Crockett L.

    1988-01-01

    The basic physics involved in proposals to use a chemical laser based on satellites for a boost-phase defense are investigated. After a brief consideration of simple physical conditions for the defense, a calculation of an equation for the number of satellites needed for the defense is made along with some typical values of this for possible future conditions for the defense. Basic energy and power requirements for the defense are determined. A sumary is made of probable minimum conditions that must be achieved for laser power, targeting accuracy, number of satellites, and total sources for power needed.

  1. 76 FR 5729 - Department of Defense Personnel Security Program (PSP)

    Science.gov (United States)

    2011-02-02

    ... of the Secretary 32 CFR Part 156 Department of Defense Personnel Security Program (PSP) AGENCY... for the Department of Defense (DoD) Personnel Security Program (PSP) in accordance with the provisions... Department of Defense Directive (DoDD) 5200.2, Personnel Security Program (PSP), codified at 32 CFR 156,...

  2. 78 FR 25853 - Defense Logistics Agency Privacy Program

    Science.gov (United States)

    2013-05-03

    ... of the Secretary 32 CFR Part 323 RIN 0790-AI86 Defense Logistics Agency Privacy Program AGENCY: Defense Logistics Agency, DoD. ACTION: Final rule. SUMMARY: The Defense Logistics Agency (DLA) is revising... Defense Logistics Agency's implementation of the Privacy Act of 1974, as amended. In addition, DLA...

  3. Defense Institution Reform Initiative Program Elements Need to Be Defined

    Science.gov (United States)

    2012-11-09

    DSCA Defense Security Cooperation Agency DASD PSO Deputy Assistant Secretary of Defense for MoDA Ministry of Defense Advisors Partnership Strategy...to the USD(P) Chief of Staff. 2 According to the DASD PSO, his office provided program management for the MoDA Program. However, according to a DASD

  4. 77 FR 46653 - Defense Logistics Agency Privacy Program

    Science.gov (United States)

    2012-08-06

    ... of the Secretary 32 CFR Part 323 RIN 0790-AI86 Defense Logistics Agency Privacy Program AGENCY: Defense Logistics Agency, DoD. ACTION: Proposed rule with request for comments. SUMMARY: The Defense Logistics Agency (DLA) is proposing to amend the DLA Privacy Program Regulation. The DLA Privacy...

  5. Second Line of Defense Spares Program Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Dale L.; Muller, George; Mercier, Theresa M.; Brigantic, Robert T.; Perkins, Casey J.; Cooley, Scott K.

    2012-11-20

    The Office of the Second Line of Defense (SLD) is part of the Department of Energy‘s (DOE) National Nuclear Security Administration (NNSA). The SLD Program accomplishes its critical global security mission by forming cooperative relationships with partner countries to install passive radiation detection systems that augment traditional inspection and law enforcement measures by alerting border officials to the presence of special nuclear or other radiological materials in cross-border traffic. An important tenet of the program is to work collaboratively with these countries to establish the necessary processes, procedures, infrastructure and conditions that will enable them to fully assume the financial and technical responsibilities for operating the equipment. As the number of operational deployments grows, the SLD Program faces an increasingly complex logistics process to promote the timely and efficient supply of spare parts.

  6. Second Line of Defense Spares Program

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Dale L.; Holmes, Aimee E.; Muller, George; Mercier, Theresa M.; Brigantic, Robert T.; Perkins, Casey J.; Cooley, Scott K.; Thorsen, Darlene E.

    2012-11-20

    During Fiscal Year 2012, a team from the Pacific Northwest National Laboratory (PNNL) conducted an assessment and analysis of the Second Line of Defense (SLD) Sustainability spare parts program. Spare parts management touches many aspects of the SLD Sustainability Program including contracting and integration of Local Maintenance Providers (LMP), equipment vendors, analyses and metrics on program performance, system state of health, and maintenance practices. Standardized spares management will provide better data for decisions during site transition phase and will facilitate transition to host country sustainability ownership. The effort was coordinated with related SLD Sustainability Program initiatives, including a configuration items baselining initiative, a metrics initiative, and a maintenance initiative. The spares study has also led to pilot programs for sourcing alternatives that include regional intermediate inventories and partnering agreements that leverage existing supply chains. Many partners from the SLD Sustainability program contributed to and were consulted in the course of the study. This document provides a description of the findings, recommendations, and implemented solutions that have resulted from the study.

  7. Department of Defense Management of Unobligated Funds for Acquisition Programs

    Science.gov (United States)

    2015-04-30

    CGFM, MBA, Senior Staff Accountant, Office of the Under Secretary of Defense (Comptroller), Financial Improvement and Audit Readiness (FIAR), 703...This research analyzes financial obligation rates for acquisition programs and acquisition program contract awards made in the last quarter of the...Postgraduate School since September 2010. Prior to that, he taught acquisition and business, cost estimating, and financial management courses at the Defense

  8. Defense Acquisitions: Assessment of Institute for Defense Analyses C-130 Avionics Modernization Program Analysis

    Science.gov (United States)

    2014-05-29

    Page 1 GAO-14-547R C-130 Avionics Modernization Program 441 G St. N.W. Washington, DC 20548 May 29, 2014...Congressional Committees Defense Acquisitions: Assessment of Institute for Defense Analyses’ C-130 Avionics Modernization Program Analysis The Air...Force’s C-130 Avionics Modernization Program (AMP), which entered development in 2001, was to standardize and upgrade the cockpit and avionics for

  9. 2011 Joint Program Executive Office for Chemical and Biological Defense Advance Planning Briefing for Industry (APBI) Held in Baltimore, Maryland on September 7-9, 2011

    Science.gov (United States)

    2011-09-09

    Biological Medical Systems ( Biosurveillance Trail Boss) Joint Project Manager Transformational Medical Technology Joint Project Manager Contamination...Systems ( Biosurveillance Trail Boss) Joint Project Manager Transformational Medical Technology Joint Project Manager Contamination Avoidance (Non...lifesaving medical countermeasure drug capabilities against chemical, biological, radiological and nuclear threats – Biosurveillance (CBMS-BSV) • Develop

  10. Defense programs beryllium good practice guide

    Energy Technology Data Exchange (ETDEWEB)

    Herr, M.

    1997-07-01

    Within the DOE, it has recently become apparent that some contractor employees who have worked (or are currently working) with and around beryllium have developed chronic beryllium disease (CBD), an occupational granulomatous lung disorder. Respiratory exposure to aerosolized beryllium, in susceptible individuals, causes an immunological reaction that can result in granulomatous scarring of the lung parenchyma, shortness of breath, cough, fatigue, weight loss, and, ultimately, respiratory failure. Beryllium disease was originally identified in the 1940s, largely in the fluorescent light industry. In 1950, the Atomic Energy Commission (AEC) introduced strict exposure standards that generally curtailed both the acute and chronic forms of the disease. Beginning in 1984, with the identification of a CBD case in a DOE contractor worker, there was increased scrutiny of both industrial hygiene practices and individuals in this workforce. To date, over 100 additional cases of beryllium-specific sensitization and/or CBD have been identified. Thus, a disease previously thought to be largely eliminated by the adoption of permissible exposure standards 45 years ago is still a health risk in certain workforces. This good practice guide forms the basis of an acceptable program for controlling workplace exposure to beryllium. It provides (1) Guidance for minimizing worker exposure to beryllium in Defense Programs facilities during all phases of beryllium-related work, including the decontamination and decommissioning (D&D) of facilities. (2) Recommended controls to be applied to the handling of metallic beryllium and beryllium alloys, beryllium oxide, and other beryllium compounds. (3) Recommendations for medical monitoring and surveillance of workers exposed (or potentially exposed) to beryllium, based on the best current understanding of beryllium disease and medical diagnostic tests available. (4) Site-specific safety procedures for all processes of beryllium that is likely to

  11. Defense Meteorological Satellite Program (DMSP) - Space Weather Sensors

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Defense Meteorological Satellite Program (DMSP) maintains a constellation of sun-synchronous, near-polar orbiting satellites. The orbital period is 101 minutes...

  12. Global Change Effects on Plant Chemical Defenses against Insect Herbivores

    Institute of Scientific and Technical Information of China (English)

    M. Gabriela Bidart-Bouzat; Adebobola Imeh-Nathaniel

    2008-01-01

    This review focuses on individual effects of major global change factors, such as elevated CO2, Oa, UV light and temperature,on plant secondary chemistry. These secondary metabolites are well-known for their role in plant defense against insect herbivory. Global change effects on secondary chemicals appear to be plant species-specific and dependent on the chemical type. Even though plant chemical responses induced by these factors are highly variable, there seems to be some specificity in the response to different environmental stressors. For example, even though the production of phenolic compounds is enhanced by both elevated CO2 and UV light levels, the latter appears to primarily increase the concentrations of fiavonoids. Likewise, specific phenolic metabolites seem to be induced by O3 but not by other factors, and an increase in volatile organic compounds has been particularly detected under elevated temperature. More information is needed regarding how global change factors influence inducibility of plant chemical defenses as well as how their indirect and direct effects impact insect performance and behavior, herbivory rates and pathogen attack. This knowledge is crucial to better understand how plants and their associated natural enemies will be affected in future changing environments.

  13. A Chemical Technology Program Partnership

    Science.gov (United States)

    Hicks, Gary

    1998-01-01

    Brazosport College would be the first to admit that they owe the success of their Chemical Technology Program to the partnership that was developed between the college and the surrounding chemical industry. The college is a two-year institution located near the Texas Gulf Coast with more than twelve chemical companies in the immediate area. Dow Chemical is the largest, employing more than 5,000. Currently, the Science Department at Brazosport College offers associate of science degrees in biology, chemistry, and physics, and associate of applied science degrees in chemical technology and instrumentation technology to meet the needs of these industries. In addition, many students enroll in classes to prepare for specific occupations or to build their skills for employment. This may only require the student to take a few courses. The current Chemical Technology Program addresses skills needed for both laboratory and process technician jobs in the chemical industry. An Associate of Applied Science Degree in Chemical Technology is offered with either a laboratory or a process option. These programs were developed with input from the chemical industry, and the college trains all new process employees for BASF and Dow. Additionally, the college does customized flexible-entry training in process operations and laboratory analysis for these and several other companies.

  14. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2015-03-01

    Assessment 56 Figure 13: Examples of Knowledge Scorecards 58 Contents Page v GAO-15-342SP Assessments of Selected Weapon Programs Abbreviations...efficiencies realized through contract negotiations (13 programs), • design trades to balance affordability and capability (10 programs), • changed...at the time of our review with a scorecard and narrative summary at the bottom of the first page of each assessment. As illustrated in figure 12

  15. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2008-03-01

    data. Technologies immature Technologies aproaching maturity Technologies fully maturePage 16 GAO-08-467SP Assessments of Selected Weapon Programs...learned and process control methods developed in the Excalibur program. The Navy anticipates that this strategy will result in mature production...risk management initiative. The RQ-4B aircraft entered a rigorous development test phase. The methodical collection of test data paces this

  16. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2016-03-01

    of contractors delivering the 10 costliest programs have performed well relative to broad-based market indices, indicating that investors expect...16-329SP Assessments of Major Weapon Programs Two programs—the B-2 Extremely High Frequency Satellite Communications and Computer...expected. The B-2 Extremely High Frequency Satellite Communications and Computer Increment 1 date was revised to reflect the actual delivery of

  17. Theater Ballistic Missile Defense Policy, Missions and Programs: Current Status

    Science.gov (United States)

    2007-11-02

    destroy its target. A French-Italian program called SAMP/T (Sol-Air Moyenne Portee/ Terrestre ) is being considered for a point defense system; further...Patriot PAC-3 missile. The Multimode Missile includes semi-active track- via -missile guidance, improved propulsion and uses an aimed blast

  18. Chemical composition of inks of diverse marine molluscs suggests convergent chemical defenses.

    Science.gov (United States)

    Derby, Charles D; Kicklighter, Cynthia E; Johnson, P M; Zhang, Xu

    2007-05-01

    Some marine molluscs, notably sea hares, cuttlefish, squid, and octopus, release ink when attacked by predators. The sea hare Aplysia californica releases secretions from the ink gland and opaline gland that protect individuals from injury or death from predatory spiny lobsters through a combination of mechanisms that include chemical deterrence, sensory disruption, and phagomimicry. The latter two mechanisms are facilitated by millimolar concentrations of free amino acids (FAA) in sea hare ink and opaline, which stimulate the chemosensory systems of predators, ultimately leading to escape by sea hares. We hypothesize that other inking molluscs use sensory disruption and/or phagomimicry as a chemical defense. To investigate this, we examined concentrations of 21 FAA and ammonium in the defensive secretions of nine species of inking molluscs: three sea hares (Aplysia californica, Aplysia dactylomela, Aplysia juliana) and six cephalopods (cuttlefish: Sepia officinalis; squid: Loligo pealei, Lolliguncula brevis, Dosidicus gigas; octopus: Octopus vulgaris, Octopus bimaculoides). We found millimolar levels of total FAA and ammonium in these secretions, and the FAA in highest concentration were taurine, aspartic acid, glutamic acid, alanine, and lysine. Crustaceans and fish, which are major predators of these molluscs, have specific receptor systems for these FAA. Our chemical analysis supports the hypothesis that inking molluscs have the potential to use sensory disruption and/or phagomimicry as a chemical defense.

  19. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2011-03-01

    cover the JPALS ship system-radio, antenna, receiver, racks , and console. The program also tracks requirement changes to monitor design stability...with stowage cradle) and berthing modules around the LCS 2 mission bay. Navy officials also report that testing of LCS 2’s twin- boom extensible

  20. Chemical defense of Hymeniacidon heliophila (Porifera: halichondrida against tropical predators

    Directory of Open Access Journals (Sweden)

    Suzi Meneses Ribeiro

    2010-12-01

    Full Text Available Various benthic organisms have chemical defenses which reduce their predators' consumption. Although their efficiency may be noticed in many organisms, many of their effects are not well- known yet. Multiple ecological roles of secondary metabolites are shown in some sponges, which may represent an adaptative advantage considering the high amount of energy used to produce these chemical compounds. The goal of this work was to investigate the defensive property of the extracts from the sponge Hymeniacidon heliophila against the tropical predators: hermit crabs (Calcinus tibicens, sea urchins (Lytechinus variegatus and generalist fishes. Extracts obtained with n-hexane, ethyl acetate and acetone/methanol were used in assays and all of them were effective in reducing the consumption by C. tibicens; n-hexane extract reduced the consumption by L. variegatus; and medium polarity extracts reduced fish consumption. Either the variation in action or the multiple ecological roles of the extracts indicates that different types of compounds can be associated to the defensive system produced by H. heliophila.Diversos organismos bênticos possuem defesas químicas que ajudam a diminuir a predação. Embora sua eficácia seja comprovada, muitos de seus efeitos são ainda desconhecidos. Múltiplas funções dos metabolitos secundários foram evidenciadas em algumas esponjas e isso pode representar uma vantagem adaptativa, considerando o alto valor energético gasto pelas espécies para produzí-los. O objetivo desse trabalho foi investigar as propriedades defensivas de extratos da esponja Hymeniacidon heliophila contra predadores tropicais: paguros (Calcinus tibicens, ouriços-do-mar (Lytechinus variegatus e peixes generalistas. Extratos em n-hexano, acetato de etila e acetona/metanol foram usados nos ensaios e todos foram eficientes na redução do consumo por C. tibicen; extratos em n-hexano reduziram o consumo por L. variegatus; e extratos de m

  1. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2012-03-01

    Inc 3 Soldier Network Extension WIN-T Inc 3 Tact i lca Communications Node (While Mobile) Program/development start (7/03) Low-rate decision (4/15...Davidson, Ramzi N. Nemo Littoral Combat Ship (LCS) Rebecca A. Wilson, Molly W. Traci Littoral Combat Ship–Mission Modules Laurier R. Fish , Mya Dinh...Warfighter Information Network-Tactical (WIN-T) Increment 2 James P. Tallon, Laurier R. Fish Warfighter Information Network-Tactical (WIN-T) Increment 3

  2. Review of Defense Display Research Programs

    Science.gov (United States)

    2001-01-01

    Programs Flat Panel Autostereoscopic N-perspective 3D High Definition DMD Digital Projector Light Piping & Quantum Cavity Displays Solid State Laser...Megapixel Displays • Size Commonality • 67 % Weight Reduction • > 200 sq. in. per Display 20-20 Vision Simulators True 3D , sparse symbols Foldable Display...megapixel 2D and True 3D Display Technology 25M & T3D FY02-FY06 New service thrusts

  3. Chemical and biological nonproliferation program. FY99 annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This document is the first of what will become an annual report documenting the progress made by the Chemical and Biological Nonproliferation Program (CBNP). It is intended to be a summary of the program's activities that will be of interest to both policy and technical audiences. This report and the annual CBNP Summer Review Meeting are important vehicles for communication with the broader chemical and biological defense and nonproliferation communities. The Chemical and Biological Nonproliferation Program Strategic Plan is also available and provides additional detail on the program's context and goals. The body of the report consists of an overview of the program's philosophy, goals and recent progress in the major program areas. In addition, an appendix is provided with more detailed project summaries that will be of interest to the technical community.

  4. Chemical defenses promote persistence of the aquatic plant Micranthemum umbrosum.

    Science.gov (United States)

    Parker, John D; Collins, Dwight O; Kubanek, Julia; Sullards, M Cameron; Bostwick, David; Hay, Mark E

    2006-04-01

    Five of the most common macrophytes from an aquaculture facility with high densities of the herbivorous Asian grass carp (Ctenopharyngodon idella) were commonly unpalatable to three generalist consumers-grass carp and the native North American crayfishes Procambarus spiculifer and P. acutus. The rooted vascular plant Micranthemum umbrosum comprised 89% of the total aboveground plant biomass and was unpalatable to all three consumers as fresh tissues, as homogenized pellets, and as crude extracts. Bioassay-guided fractionation of the crude extract from M. umbrosum led to four previously known compounds that each deterred feeding by at least one consumer: 3,4,5-trimethoxyallylbenzene (1) and three lignoids: beta-apopicropodophyllin (2); (-)-(3S,4R,6S)-3-(3',4'-methylenedioxy-alpha-hydroxybenzyl)-4-(3'',4''-dimethoxybenzyl)butyrolactone (3); and (-)-hibalactone (4). None of the remaining four macrophytes produced a chemically deterrent extract. A 16-mo manipulative experiment showed that the aboveground biomass of M. umbrosum was unchanged when consumers were absent, but the biomass of Ludwigia repens, a plant that grass carp preferentially consumed over M. umbrosum, increased over 300-fold. Thus, selective feeding by grass carp effectively eliminates most palatable plants from this community and promotes the persistence of the chemically defended M. umbrosum, suggesting that plant defenses play critical yet understudied roles in the structure of freshwater plant communities.

  5. Novel Method of Estimating Metabolic Rates of Soldiers Engaged in Chemical Biological Defense Training

    Science.gov (United States)

    2016-12-01

    SOLDIERS ENGAGED IN CHEMICAL BIOLOGICAL DEFENSE TRAINING DISCLAIMER The opinions or assertions contained herein are the private views of the...USARIEM TECHNICAL REPORT TR17-02 NOVEL METHOD OF ESTIMATING METABOLIC RATES OF SOLDIERS ENGAGED IN CHEMICAL BIOLOGICAL DEFENSE TRAINING ...Volunteers ............................................................................................................ 2 Training Activities

  6. An Analysis of the Relationship Between the Professionalism of Defense Acquisition Program Managers and Program Outcomes

    Science.gov (United States)

    2011-11-30

    for example, Fox & Miller, 2006; Kronenberg , 1990) have noted the high level of complexity in defense acquisition programs. Several interviewees in...CA: Berrett–Koehler. Kronenberg , P. S. (1990). Public administration and the Defense Department: Examination of a prototype. In G. Wamsley et al

  7. Analysis to Support Execution of the Defense Environmental International Cooperation (DEIC) Program

    Science.gov (United States)

    2012-05-01

    IDA Document D-4605 May 2012 Analysis to Support Execution of the Defense Environmental International Cooperation ( DEIC ) Program Susan L. Clark...Execution of the Defense Environmental International Cooperation ( DEIC ) Program Susan L. Clark-Sestak iii Executive Summary The Defense...Environmental International Cooperation ( DEIC ) program is managed by the Director of Environmental Readiness and Safety (ERS) in the Office of the Deputy

  8. 77 FR 62469 - Defense Logistics Agency Freedom of Information Act Program

    Science.gov (United States)

    2012-10-15

    ... of the Secretary 32 CFR Part 300 Defense Logistics Agency 32 CFR Part 1285 RIN 0790-AI87 Defense Logistics Agency Freedom of Information Act Program AGENCY: Defense Logistics Agency, DoD. ACTION: Proposed rule. SUMMARY: The Defense Logistics Agency (DLA) proposes to revise and update its existing...

  9. Trends in Nunn-McCurdy Cost Breaches for Major Defense Acquisition Programs

    Science.gov (United States)

    2011-03-09

    Demilitarization - Chemical Materials Agency Bechtel National Inc., Westinghouse, Washington Demil Co., EG&G Defense Materials, Parsons Infra...Engineers & Construction, Raytheon Demil Company, Bechtel National, Inc., EG&G Defense Materials Comanche Reconnaissance Attack Helicopter Boeing

  10. Fitness costs of chemical defense in Plantago lanceolata L.: effects of nutrient and competition stress

    NARCIS (Netherlands)

    Marak, H.B.; Biere, A.; Van Damme, J.M.M.

    2003-01-01

    Fitness costs of defense are often invoked to explain the maintenance of genetic variation in levels of chemical defense compounds in natural plant populations. We investigated fitness costs of iridoid glycosides (IGs), terpenoid compounds that strongly deter generalist insect herbivores, in ribwort

  11. Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 1. Civil Defense - Protection Against What?

    Science.gov (United States)

    Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

    An explanation of the need for civil defense in nuclear and natural disasters is presented. A brief historical background of civil defense is given. Major topics include: (1) Types of disasters, (2) Probable objectives of a nuclear attack on the United States, (3) The major defensive measures against a nuclear attack, (4) Some reasons for low…

  12. Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 5. Governmental Responsibilities for Civil Defense.

    Science.gov (United States)

    Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

    A description of the laws and orders that provide necessary legal authorization for civil defense activities is provided. In addition, an outline of the responsibilities of all governments and the role of the private sector in civil defense is presented. Topics discussed include: (1) Legal authority for civil defense, (2) Civil defense…

  13. Consequences arising from the activities of the Mining and Chemical Enterprise, a defense production association, and influence of the public opinion on decision-making

    Energy Technology Data Exchange (ETDEWEB)

    Lazarev, L.N.; Kuznetsov, Yu.V. [Khlopin Radium Inst., St. Petersburg (Russian Federation); Zhidkov, V.V. [Mining and Chemical Enterprise, Zheleznogorsk (Russian Federation); Mel`nikov, G.Y. [Central Medical Office 51, Zheleznogorsk (Russian Federation)

    1995-12-31

    Mining and Chemical Enterprise was created during the Cold War in Russia to produce plutonium for defense purposes. Now, when these activities are stopped, prime attention is given to the evaluation of impacts caused by the execution of the defense program and to the conversion possibilities of the enterprise for provisions of the nuclear fuel cycle. The role of public opinion in solving these problems is considered.

  14. Plant chemical defense against herbivores and pathogens: generalized defense or trade-offs?

    NARCIS (Netherlands)

    Biere, A.; Marak, H.B.; Van Damme, J.M.M.

    2004-01-01

    Plants are often attacked by multiple enemies, including pathogens and herbivores. While many plant secondary metabolites show specific effects toward either pathogens or herbivores, some can affect the performance of both these groups of natural enemies and are considered to be generalized defense

  15. SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 38 (April 2009)

    OpenAIRE

    2009-01-01

    This April 2009 issue of the Naval Postgraduate School (NPS) Maritime Defense and Security Research Program Newsletter highlights the following research: "Join MDA [Maritime Defense and Awareness] Outreach on ODNI [Office of the Director of National Intelligence] Bridge" and "NPS Cooperative Operations and Applied Science & Technology Studies." It also provides links to future events, reports, articles, and NPS Theses regarding maritime defense and security.

  16. Dryden Flight Research Center Chemical Pharmacy Program

    Science.gov (United States)

    Davis, Bette

    1997-01-01

    The Dryden Flight Research Center (DFRC) Chemical Pharmacy "Crib" is a chemical sharing system which loans chemicals to users, rather than issuing them or having each individual organization or group purchasing the chemicals. This cooperative system of sharing chemicals eliminates multiple ownership of the same chemicals and also eliminates stockpiles. Chemical management duties are eliminated for each of the participating organizations. The chemical storage issues, hazards and responsibilities are eliminated. The system also ensures safe storage of chemicals and proper disposal practices. The purpose of this program is to reduce the total releases and transfers of toxic chemicals. The initial cost of the program to DFRC was $585,000. A savings of $69,000 per year has been estimated for the Center. This savings includes the reduced costs in purchasing, disposal and chemical inventory/storage responsibilities. DFRC has chemicals stored in 47 buildings and at 289 locations. When the program is fully implemented throughout the Center, there will be three chemical locations at this facility. The benefits of this program are the elimination of chemical management duties; elimination of the hazard associated with chemical storage; elimination of stockpiles; assurance of safe storage; assurance of proper disposal practices; assurance of a safer workplace; and more accurate emissions reports.

  17. Defense High-Level Waste Leaching Mechanisms Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Mendel, J.E. (compiler)

    1984-08-01

    The Defense High-Level Waste Leaching Mechanisms Program brought six major US laboratories together for three years of cooperative research. The participants reached a consensus that solubility of the leached glass species, particularly solubility in the altered surface layer, is the dominant factor controlling the leaching behavior of defense waste glass in a system in which the flow of leachant is constrained, as it will be in a deep geologic repository. Also, once the surface of waste glass is contacted by ground water, the kinetics of establishing solubility control are relatively rapid. The concentrations of leached species reach saturation, or steady-state concentrations, within a few months to a year at 70 to 90/sup 0/C. Thus, reaction kinetics, which were the main subject of earlier leaching mechanisms studies, are now shown to assume much less importance. The dominance of solubility means that the leach rate is, in fact, directly proportional to ground water flow rate. Doubling the flow rate doubles the effective leach rate. This relationship is expected to obtain in most, if not all, repository situations.

  18. Defense programs industrial partnerships at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Freese, K.B. [Los Alamos National Lab., NM (United States). Industrial Partnership Office

    1996-10-01

    The US Department of Energy`s Defense Programs face unprecedented challenges of stewardship for an aging nuclear stockpile, cessation of nuclear testing, reduced federal budgets, and a smaller manufacturing complex. Partnerships with industry are essential in developing technology, modernizing the manufacturing complex, and maintaining the safety and reliability of the nation`s nuclear capability. The past decade of federal support for industrial partnerships has promoted benefits to US industrial competitiveness. Recent shifts in government policy have re-emphasized the importance of industrial partnerships in accomplishing agency missions. Nevertheless, abundant opportunities exist for dual-benefit, mission-driven partnerships between the national laboratories and industry. Experience at Los Alamos National Laboratory with this transition is presented.

  19. Quantitative and qualitative shifts in defensive metabolites define chemical defense investment during leaf development in Inga, a genus of tropical trees.

    Science.gov (United States)

    Wiggins, Natasha L; Forrister, Dale L; Endara, María-José; Coley, Phyllis D; Kursar, Thomas A

    2016-01-01

    Selective pressures imposed by herbivores are often positively correlated with investments that plants make in defense. Research based on the framework of an evolutionary arms race has improved our understanding of why the amount and types of defenses differ between plant species. However, plant species are exposed to different selective pressures during the life of a leaf, such that expanding leaves suffer more damage from herbivores and pathogens than mature leaves. We hypothesize that this differential selective pressure may result in contrasting quantitative and qualitative defense investment in plants exposed to natural selective pressures in the field. To characterize shifts in chemical defenses, we chose six species of Inga, a speciose Neotropical tree genus. Focal species represent diverse chemical, morphological, and developmental defense traits and were collected from a single site in the Amazonian rainforest. Chemical defenses were measured gravimetrically and by characterizing the metabolome of expanding and mature leaves. Quantitative investment in phenolics plus saponins, the major classes of chemical defenses identified in Inga, was greater for expanding than mature leaves (46% and 24% of dry weight, respectively). This supports the theory that, because expanding leaves are under greater selective pressure from herbivores, they rely more upon chemical defense as an antiherbivore strategy than do mature leaves. Qualitatively, mature and expanding leaves were distinct and mature leaves contained more total and unique metabolites. Intraspecific variation was greater for mature leaves than expanding leaves, suggesting that leaf development is canalized. This study provides a snapshot of chemical defense investment in a speciose genus of tropical trees during the short, few-week period of leaf development. Exploring the metabolome through quantitative and qualitative profiling enables a more comprehensive examination of foliar chemical defense investment.

  20. Plant chemical defense against herbivores and pathogens: generalized defense or trade-offs?

    Science.gov (United States)

    Biere, Arjen; Marak, Hamida B; van Damme, Jos M M

    2004-08-01

    Plants are often attacked by multiple enemies, including pathogens and herbivores. While many plant secondary metabolites show specific effects toward either pathogens or herbivores, some can affect the performance of both these groups of natural enemies and are considered to be "generalized defense compounds". We tested whether aucubin and catalpol, two iridoid glycosides present in ribwort plantain (Plantago lanceolata), confer in vivo resistance to both the generalist insect herbivore Spodoptera exigua and the biotrophic fungal pathogen Diaporthe adunca using plants from P. lanceolata lines that had been selected for high- and low-leaf iridoid glycoside concentrations for four generations. The lines differed approximately three-fold in the levels of these compounds. Plants from the high-selection line showed enhanced resistance to both S. exigua and D. adunca, as evidenced by a smaller lesion size and a lower fungal growth rate and spore production, and a lower larval growth rate and herbivory under both choice and no-choice conditions. Gravimetric analysis revealed that the iridoid glycosides acted as feeding deterrents to S. exigua, thereby reducing its food intake rate, rather than having post-ingestive toxic effects as predicted from in vitro effects of hydrolysis products. We suggest that the bitter taste of iridoid glycosides deters feeding by S. exigua, whereas the hydrolysis products formed after tissue damage following fungal infection mediate pathogen resistance. We conclude that iridoid glycosides in P. lanceolata can serve as broad-spectrum defenses and that selection for pathogen resistance could potentially result in increased resistance to generalist insect herbivores and vice versa, resulting in diffuse rather than pairwise coevolution.

  1. Space-Based Chemical Lasers in Strategic Defense

    Science.gov (United States)

    2007-11-02

    using <fJ*™’™ „, „,,„,,; rrÄr^ÄSXnceuea. MlRACL Chemical laser at White planned for 1995. ssssSS Sands New Mexico ^f Tit:*n s«ron»1 «>ta<J*’f...AsswnHY P«o Su<«y CS2 Secwios CaoaMitv LPE 10,412 OPE 12.323 S/C with Test Objects 12,382 Subtotal 35,117 Titan IVA Margin !32.7°.o

  2. Current knowledge and future research perspectives on cassava (Manihot esculenta Crantz) chemical defenses: An agroecological view.

    Science.gov (United States)

    Pinto-Zevallos, Delia M; Pareja, Martín; Ambrogi, Bianca G

    2016-10-01

    Cassava (Manihot esculenta Crantz) is one of the most important staple crops worldwide. It constitutes the major source of carbohydrates for millions of low-income people living in rural areas, as well as a cash crop for smallholders in tropical and sub-tropical regions. The Food and Agriculture Organization of the United Nations predicts that cassava plantations will increase and production systems will intensify in the future, highlighting the need for developing strategies that improve the sustainability of production. Plant chemical defenses hold the potential for developing pest management strategies, as these plant traits can influence the behavior and performance of both pests and beneficial arthropods. Cassava plants are well-defended and produce a number of compounds involved in direct defense, such as cyanogenic glycosides, flavonoid glycosides, and hydroxycoumarins. In addition, volatile organic compounds induced upon herbivory and the secretion of extrafloral nectar act as indirect defense against herbivores by recruiting natural enemies. Here, cassava chemical defenses against pest arthropods are reviewed, with the aim of identifying gaps in our knowledge and areas of research that deserve further investigation for developing sound pest control strategies to improve sustainable production of this crop, and how these defenses can be used to benefit other crops. Cyanogenic content in cassava is also highly toxic to humans, and can cause irreversible health problems even at sub-lethal doses when consumed over prolonged periods. Therefore, the promotion of chemical defense in this crop should not aggravate these problems, and must be accompanied with the education on processing methods that reduce human exposure to cyanide.

  3. Establishing a Department of Defense Program Management Body of Knowledge

    Science.gov (United States)

    1991-09-01

    Initiation, Implementation, and Termination (19:10-11). Another definition can be gained from Dr David Cleland, in his text Project Management Strategies...The Defense Systems Management College (DSMC) was established in 1971 under the direction of Deputy Secretary of Defense David Packard (5:5).. The...intelligence activities, cryptological activities, omand and control, equipment that is an integral part of a weapon or weapon system, equipment critical

  4. Isolated and synergistic effects of chemical and structural defenses of two species of Tethya (Porifera: Demospongiae)

    Science.gov (United States)

    Ribeiro, Suzi Meneses; Cassiano, Keila Mara; Cavalcanti, Diana Negrão; Teixeira, Valéria Laneuville; Pereira, Renato Crespo

    2012-02-01

    Sponges are an important source of many interesting secondary metabolites with multiple ecological roles. Sponges can also use their spicules as a means of deterring consumers. The present study investigated the importance of chemicals and spicules as defensive strategies against predation for two congeneric sponge species from the Brazilian coast, Tethya rubra and Tethya maza. Crude extract and spicules differed somewhat in their effectiveness between these sponge species, with T. maza better defended than T. rubra against predation by the hermit crab Calcinus tibicen and synergistic effects stronger in T. rubra. These results show that defensive strategies may be similar between sponge species possessing monophyletic origin, and reveal the importance of research on congeneric species to understand the ecology and evolution of defensive strategies.

  5. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  6. Environmental assessment of defense environmental restoration program activities on St. Lawrence Island

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The magnitude and extent of environmental impacts associated with Defense environmental Restoration Program activities at Gambell and Northeast Cape varies. The...

  7. Department of Defense DOD Freedom of Information Act Program

    Science.gov (United States)

    1998-09-01

    reader . The statements of rules do not create rights or remedies not otherwise available, nor do they bind the Department of Defense to particular...COMPUTER COPY.- Ente the total number of tapes and/or sprepring the necessary correspondence and! tarot . to answer the printouts. requaA. - MAI by

  8. A specialist herbivore uses chemical camouflage to overcome the defenses of an ant-plant mutualism.

    Directory of Open Access Journals (Sweden)

    Susan R Whitehead

    Full Text Available Many plants and ants engage in mutualisms where plants provide food and shelter to the ants in exchange for protection against herbivores and competitors. Although several species of herbivores thwart ant defenses and extract resources from the plants, the mechanisms that allow these herbivores to avoid attack are poorly understood. The specialist insect herbivore, Piezogaster reclusus (Hemiptera: Coreidae, feeds on Neotropical bull-horn acacias (Vachellia collinsii despite the presence of Pseudomyrmex spinicola ants that nest in and aggressively defend the trees. We tested three hypotheses for how P. reclusus feeds on V. collinsii while avoiding ant attack: (1 chemical camouflage via cuticular surface compounds, (2 chemical deterrence via metathoracic defense glands, and (3 behavioral traits that reduce ant detection or attack. Our results showed that compounds from both P. reclusus cuticles and metathoracic glands reduce the number of ant attacks, but only cuticular compounds appear to be essential in allowing P. reclusus to feed on bull-horn acacia trees undisturbed. In addition, we found that ant attack rates to P. reclusus increased significantly when individuals were transferred between P. spinicola ant colonies. These results are consistent with the hypothesis that chemical mimicry of colony-specific ant or host plant odors plays a key role in allowing P. reclusus to circumvent ant defenses and gain access to important resources, including food and possibly enemy-free space. This interaction between ants, acacias, and their herbivores provides an excellent example of the ability of herbivores to adapt to ant defenses of plants and suggests that herbivores may play an important role in the evolution and maintenance of mutualisms.

  9. A specialist herbivore uses chemical camouflage to overcome the defenses of an ant-plant mutualism.

    Science.gov (United States)

    Whitehead, Susan R; Reid, Ellen; Sapp, Joseph; Poveda, Katja; Royer, Anne M; Posto, Amanda L; Kessler, André

    2014-01-01

    Many plants and ants engage in mutualisms where plants provide food and shelter to the ants in exchange for protection against herbivores and competitors. Although several species of herbivores thwart ant defenses and extract resources from the plants, the mechanisms that allow these herbivores to avoid attack are poorly understood. The specialist insect herbivore, Piezogaster reclusus (Hemiptera: Coreidae), feeds on Neotropical bull-horn acacias (Vachellia collinsii) despite the presence of Pseudomyrmex spinicola ants that nest in and aggressively defend the trees. We tested three hypotheses for how P. reclusus feeds on V. collinsii while avoiding ant attack: (1) chemical camouflage via cuticular surface compounds, (2) chemical deterrence via metathoracic defense glands, and (3) behavioral traits that reduce ant detection or attack. Our results showed that compounds from both P. reclusus cuticles and metathoracic glands reduce the number of ant attacks, but only cuticular compounds appear to be essential in allowing P. reclusus to feed on bull-horn acacia trees undisturbed. In addition, we found that ant attack rates to P. reclusus increased significantly when individuals were transferred between P. spinicola ant colonies. These results are consistent with the hypothesis that chemical mimicry of colony-specific ant or host plant odors plays a key role in allowing P. reclusus to circumvent ant defenses and gain access to important resources, including food and possibly enemy-free space. This interaction between ants, acacias, and their herbivores provides an excellent example of the ability of herbivores to adapt to ant defenses of plants and suggests that herbivores may play an important role in the evolution and maintenance of mutualisms.

  10. Fitness costs of chemical defense in Plantago lanceolata L.: effects of nutrient and competition stress.

    Science.gov (United States)

    Marak, Hamida B; Biere, Arjen; Van Damme, Jos M M

    2003-11-01

    Fitness costs of defense are often invoked to explain the maintenance of genetic variation in levels of chemical defense compounds in natural plant populations. We investigated fitness costs of iridoid glycosides (IGs), terpenoid compounds that strongly deter generalist insect herbivores, in ribwort plantain (Plantago lanceolata L.) using lines that had been artificially selected for high and low leaf IG concentrations for four generations. Twelve maternal half-sib families from each selection line were grown in four environments, consisting of two nutrient and two competition treatments. We tested whether: (1) in the absence of herbivores and pathogens, plants from lines selected for high IG levels have a lower fitness than plants selected for low IG levels; and (2) costs of chemical defense increase with environmental stress. Vegetative biomass did not differ between selection lines, but plants selected for high IG levels produced fewer inflorescences and had a significantly lower reproductive dry weight than plants selected for low IG levels, indicating a fitness cost of IG production. Line-by-nutrient and line-by-competition interactions were not significant for any of the fitness-related traits. Hence, there was no evidence that fitness costs increased with environmental stress. Two factors may have contributed to the absence of higher costs under environmental stress. First, IGs are carbon-based chemicals. Under nutrient limitation, the relative carbon excess may result in the production of IGs without imposing a further constraint on growth and reproduction. Second, correlated responses to selection on IG levels indicate the existence of a positive genetic association between IG level and cotyledon size. At low nutrient level, a path analysis based on family means revealed that in the presence of competitors, the negative direct effect of a high IG level on aboveground plant dry weight was partly offset by a positive direct effect of the associated larger

  11. Defense Standardization Program Journal, July/December 2007

    Science.gov (United States)

    2007-12-01

    potcti, t response, i ndtrianurcspa. so Various tecnicaity ris ailol lig o enrg reolution, w ieel sensitivit,adpisce t] C,1Ci ited the raelal ity ofa... mental users and industrial partners with uniforn methods to compare technical aspects re- lated to perforinance and standard gauges that will...measurement traceability for the nation’s medical, industrial, environ- mental , defense, homeland security, energy, and radiation-protectiou

  12. Chemical defense balanced by sequestration and de novo biosynthesis in a lepidopteran specialist.

    Directory of Open Access Journals (Sweden)

    Joel Fürstenberg-Hägg

    Full Text Available The evolution of sequestration (uptake and accumulation relative to de novo biosynthesis of chemical defense compounds is poorly understood, as is the interplay between these two strategies. The Burnet moth Zygaena filipendulae (Lepidoptera and its food-plant Lotus corniculatus (Fabaceae poses an exemplary case study of these questions, as Z. filipendulae belongs to the only insect family known to both de novo biosynthesize and sequester the same defense compounds directly from its food-plant. Z. filipendulae and L. corniculatus both contain the two cyanogenic glucosides linamarin and lotaustralin, which are defense compounds that can be hydrolyzed to liberate toxic hydrogen cyanide. The overall amounts and ratios of linamarin and lotaustralin in Z. filipendulae are tightly regulated, and only to a low extent reflect the ratio in the ingested food-plant. We demonstrate that Z. filipendulae adjusts the de novo biosynthesis of CNglcs by regulation at both the transcriptional and protein level depending on food plant composition. Ultimately this ensures that the larva saves energy and nitrogen while maintaining an effective defense system to fend off predators. By using in situ PCR and immunolocalization, the biosynthetic pathway was resolved to the larval fat body and integument, which infers rapid replenishment of defense compounds following an encounter with a predator. Our study supports the hypothesis that de novo biosynthesis of CNglcs in Z. filipendulae preceded the ability to sequester, and facilitated a food-plant switch to cyanogenic plants, after which sequestration could evolve. Preservation of de novo biosynthesis allows fine-tuning of the amount and composition of CNglcs in Z. filipendulae.

  13. Arbuscular mycorrhizal fungi alter above- and below-ground chemical defense expression differentially among Asclepias species

    Directory of Open Access Journals (Sweden)

    Rachel L Vannette

    2013-09-01

    Full Text Available Belowground symbionts of plants can have substantial influence on plant growth and nutrition. Recent work demonstrates that mycorrhizal fungi can affect plant resistance to herbivory and the performance of above and belowground herbivores. Although these examples emerge from diverse systems, it is unclear if plant species that express similar defensive traits respond similarly to fungal colonization, but comparative work may inform this question. To examine the effects of arbuscular mycorrhizal fungi (AMF on the expression of chemical resistance, we inoculated 8 species of Asclepias (milkweed--which all produce toxic cardenolides--with a community of AMF. We quantified plant biomass, foliar and root cardenolide concentration and composition, and assessed evidence for a growth-defense tradeoff in the presence and absence of AMF. As expected, total foliar and root cardenolide concentration varied among milkweed species. Importantly, the effect of mycorrhizal fungi on total foliar cardenolide concentration also varied among milkweed species, with foliar cardenolides increasing or decreasing, depending on the plant species. We detected a phylogenetic signal to this variation; AMF fungi reduced foliar cardenolide concentrations to a greater extent in the clade including A. curassavica than in the clade including A. syriaca. Moreover, AMF inoculation shifted the composition of cardenolides in above- and below-ground plant tissues in a species-specific fashion. Mycorrhizal inoculation changed the relative distribution of cardenolides between root and shoot tissue in a species-specific fashion, but did not affect cardenolide diversity or polarity. Finally, a tradeoff between plant growth and defense in non-mycorrhizal plants was mitigated completely by AMF inoculation. Overall, we conclude that the effects of AMF inoculation on the expression of chemical resistance can vary among congeneric plant species, and ameliorate tradeoffs between growth and

  14. Identifying Enterprise Leverage Points in Defense Acquisition Program Performance

    Science.gov (United States)

    2009-09-01

    Planning Guidance SPI Schedule Efficiency SPO System Program Office SPOC Special Access Required (SAR) Programs Oversight Committee SPRG...Air Force office of Financial Management and Budget; SES = Senior Executive Service; SPOC /SPRG/SAR = classified financial review system for

  15. Wolbachia-Free Heteropterans Do Not Produce Defensive Chemicals or Alarm Pheromones.

    Science.gov (United States)

    Becerra, Judith X; Venable, Gabriela X; Saeidi, Vahid

    2015-07-01

    The true bugs, or heteropterans, are known for their widespread production of anti-predator chemicals and alarm pheromones in scent glands, a derived trait that constitutes one of the defining characters of the suborder Heteroptera and a potential novel trait that contributed to their diversification. We investigated whether symbiotic bacteria could be involved in the formation of these chemicals using Thasus neocalifornicus, a coreid bug that produces semiochemicals frequently found in other bugs. Using DNA phylogenetic methodology and experiments using antibiotics coupled with molecular techniques, we identified Wolbachia as the microorganism infecting the scent glands of this bug. Decreasing the level of Wobachia infection using antibiotics was correlated with a diminution of heteropteran production of defensive compounds and alarm pheromones, suggesting that this symbiotic bacterium might be implicated in the formation of chemicals.

  16. Defense Acquisitions: Assessments of Selected Major Weapon Programs

    Science.gov (United States)

    2006-03-01

    Common Name: C-130 AMPC -130 Avionics Modernization Program (C-130 AMP)The Air Force’s C-130 AMP standardizes the cockpit configurations and avionics for...GAO-06-391 Assessments of Selected Major Weapon Programs Common Name: C-130 AMPC -130 AMP Program Technology Maturity All of the C-130 AMP’s six...Selected Major Weapon Programs Common Name: C-5 AMPC -5 Avionics Modernization Program (C-5 AMP)The Air Force’s C-5 AMP is the first of two major upgrades

  17. Compendium of Programs to Assist the Transition. Annex G to Adjusting to the Drawdown. Report to the Defense Conversion Commission,

    Science.gov (United States)

    1993-02-01

    5235 (for civilian registrants) The Defense Outplacement Referral System (DORS). The DORS is an automated registry of "mini-resumes" of military...identifying employers who are interested in hiring former Army personnel. The existing DoD databanks, such as the Defense Outplacement Referral...Training Partnership Act Ine Secretary of Defense may coordinate this program with the Defense Outplacement Referral System (DORS) and other automated job

  18. Digging Out the Root Cause: Nunn-McCurdy Breaches in Major Defense Acquisition Programs

    Science.gov (United States)

    2014-04-30

    Acquisition Programs Bill Shelton, RAND Corporation Irv Blickstein, RAND Corporation Jerry Sollinger, RAND Corporation Charles Nemfakos, RAND...to become a research sponsor, or to print additional copies of reports, please contact any of the staff listed on the Acquisition Research Program...Out the Root Cause: Nunn-McCurdy Breaches in Major Defense Acquisition Programs Bill Shelton, RAND Corporation Irv Blickstein, RAND Corporation

  19. Department of Defense Biological Defense Program Needs for Strategic Biotechnology Development

    Science.gov (United States)

    2013-05-16

    Command and Control 4 Bacteria /Rickettsia Viruses Toxins Anthrax Smallpox Botulinum Brucellosis Rift Valley Fever Ricin Cholera Crimean-Congo SEB Plague...structural biology − Establish research programs in aerobiological research, forensic genomics and certified forensic biological threat agent capability

  20. Operate A Chemical Surety Program And Studies Supporting The Medical Chemical Defense Research Program

    Science.gov (United States)

    2010-05-01

    Administrations Following Intravenous Poisoning with Potassium Cyanide in Adult Male Beagle Dogs...Administrations Following Intravenous Poisoning with Potassium Cyanide in Adult Male Beagle Dogs Task Leader: Dr. Frances Reid / Dr. Brian Roche...agents, synthesis , pharmacokinetics, efficacy testing, seizure control, bioscavengers, toxicology testing and test kit evaluations. In addition, TO

  1. SDI (Strategic Defense Initiative) Software Technology Program Plan

    Science.gov (United States)

    1987-06-01

    Computing Initiative program under Simpson and Sears . Industrial research labs are studying fundamental issues of the man-machine interface to formulate...Reform," The Brookings Review, Summer 1986, pp. 11-16. [Maidique 80] Maidique, Modesto , "Entrepreneurs, Champions, and % Technological Innovation...Management Tasks Area," from Computer t. Special Issue on STARS Program, (November 1983), pp. 56-62. [Maidique 80] Maidique, Modesto A., "Entrepreneurs

  2. Regulatory Burden and Poor Defense Acquisition Program Outcomes

    Science.gov (United States)

    2014-05-01

    drive program improvements • Econometric modeling lesson is that this is opportunity for better understanding of cause, effect, and explanation of...Agenda • Overview • Previous Work • Method • Data • Models • Results • Interpretation • Conclusions • Future Work © 2014 by the University of Tennessee...regulation or reforms? – Previously modeled as the correlation and direction of change for a key performance metric for a program in the years following the

  3. The Need for Reforming the Department of Defense Retirement Program

    Science.gov (United States)

    2010-06-04

    year vestment and immediate annuity is one of the best pension program available to a non-disabled employee in America. No other governmental of civil... pension programs have the potential to provide a retirement annuity for twice as long as the employment status. Even at a portion of the employment...such a way that is fair to current and retired service members it must grandfather the basic annuity . Furthermore, failure to act now will only delay

  4. Implementing Effective Affordability Constraints for Defense Acquisition Programs

    Science.gov (United States)

    2014-03-01

    between 1999 and 2009. Since several of those programs advertised themselves as employing the CAIV concept, the IDA team was able to draw on that...and mutable to yield to stereotyped or routinized processes. The processes associated with CAIV are tools that can help achieve powerful results if...Vehicle (EELV). Each of these FPPs, as well as four other prominent programs that advertised use of CAIV, will be reviewed in this appendix to help to

  5. Defense Small Business Innovation Research Program (SBIR) FY 1985.

    Science.gov (United States)

    1985-01-31

    Nula Projects Agency Agency F hk ~Closing Date: 31 January 1985 for p 1t -1 c - iud__.:C1: its 1 di.-tiibutinf i.; unlimitod -. ~$* ~ W, R1 Ix SBR AY18...suitable chemical kinetics equations for the pyrolysis and oxidation of hydrocarbon fuels. New mixing and kinetics sub- ..- models are needed that can be

  6. 76 FR 55883 - Department of Defense Program for Construction, Renovation, Repair or Expansion of Public Schools...

    Science.gov (United States)

    2011-09-09

    ....'' OEA is establishing a one-time non-competitive program, as described in this notice, to administer... Secretary of Defense for Personnel and Readiness, attention: Russell Roberts, Chief, Logistics Division..., and to structure proposals to take best advantage of other contributions. OEA may waive part or...

  7. Modeling an integrative physical examination program for the Departments of Defense and Veterans Affairs.

    Science.gov (United States)

    Goodrich, Scott G

    2006-10-01

    Current policies governing the Departments of Defense and Veterans Affairs physical examination programs are out of step with current evidence-based medical practice. Replacing periodic and other routine physical examination types with annual preventive health assessments would afford our service members additional health benefit at reduced cost. Additionally, the Departments of Defense and Veterans Affairs repeat the physical examination process at separation and have been unable to reconcile their respective disability evaluation systems to reduce duplication and waste. A clear, coherent, and coordinated strategy to improve the relevance and utility of our physical examination programs is long overdue. This article discusses existing physical examination programs and proposes a model for a new integrative physical examination program based on need, science, and common sense.

  8. Defesas químicas de plantas: fitoalexinas Chemical defense of plants: phytoalexins

    Directory of Open Access Journals (Sweden)

    Márcia Regina Braga

    1987-01-01

    Full Text Available A resistência de plantas ao ataque de microorganismos causadores de doenças relaciona-se à presença de barreiras físicas e (juímicas de defesa. Dentre as barreiras químicas destacam-se as fitoalexinas, substâncias fungitoxicas sintetizadas de novo pelas plantas principalmente após a invasão ou o contato de seus tecidos com microorganismos, Essas substâncias englobam vários grupos compostos naturais tais como terpenos, isoflavonóides e poliacetilenos e seu acúmulo pode ser induzido por organismos vivos, seus produtos (elíciadores ou ainda agentes químicos, como sais de metais pesados, ou físicos (congelamento, luz U.U.. Alguns aspectos abordados nesta revisão são: a ocorrência de fitoalexinas em angiospermas, a relação entre sua natureza química e o grupo taxonômico das plantas que as produzem, a sua ação sobre organismos pró e eucarióticos. São descritas também os fatores que interferem nas respostas das plantas aos agentes indutores e as técnicas usuais para a indução e detecção de fitoalexinas. O papel dos eliciadores na indução da sâitese de fitoalexinas e o mecanismo pelo qual exercem sua função indutora são discutidos. Nesse contexto está incluída a teoria das oligossacarinas, fragmentos de parede celular que parecem controlar não só a resposta de defesa em plantas mas também outros fenômenos fisiológicos em plantas.Chemical defense of plants: phytoalexins - This review describes the concept of phytoalexins as a chemical defense of plants against microorganisms as well as a response of plants to chemical or physical agents. The current information on phytoalexins is presented, regarding the following aspects: occurrence in angiosperms; relation-snips between chemical composition and taxonomy; toxicity; factors affecting plant response; techniques for induction and detection of phytoalexins; role of elicitors and mechanisms of action. The latter includes the oligosaccharins-fragments of cell

  9. Defense Small Business Innovation Research Program (SBIR) FY 1983.

    Science.gov (United States)

    1983-05-31

    that within a repeater module, the battery would be the most expensive component. Present technology suggests the use of a lithium thionyl chloride ...mercial lithium -sulfur dioxide or lithium - thionyl chloride cells, and propose a change in the materials, configuration, production process, or...rechargeable lithium batteries . Intercalates wlll be described in terms of chemical content, structure, etc., in quantities of 100 grams each. ." i. Electron

  10. Defense Coastal/Estuarine Research Program (DCERP) Strategic Plan

    Science.gov (United States)

    2007-09-01

    efforts will be used to refine the information system architecture of DCERP. Module teams might also develop modeling tools that integrate...sound shoreline. Rare beach plants are sensitive to storm impacts, and some species, such as the seabeach amaranth , may even be enhanced by such...degradation of dune plants that help trap and stabilize sand. Military traffic also may leave chemical residues (e.g., oil , gas) on the island. In

  11. Defense Acquisition University (DAU) Program Managers Tool Kit

    Science.gov (United States)

    2008-03-01

    addtonal KPPs are requred for selected programs: system tranng and energy effic ency. • The MDA may add other sgnficant performance parameters...plans and other AT&L products accurately and effic ently. The followng PPLTs have been developed: • Prcng Support Tool <http://prcngtool.dau.ml

  12. Defense Surplus Equipment Disposal, Including the Law Enforcement 1033 Program

    Science.gov (United States)

    2014-09-05

    Helicopters 7- High Mobility Multipurpose Vehicles 2 -Night vision equipment 2 - Robots Other general property Firefighting Support Program Title...to the Secretary of Agriculture and the Secretary of Homeland Security for use by the Forest Service and the U.S. Coast Guard.31 P.L. 112-81 (H.R

  13. A Best Practices Based Approach to Major Defense Acquisition Programs

    Science.gov (United States)

    2010-04-26

    EBSCO . Web. 10 Apr. 2010. Heberling, Michael E. "Open Issues in Acquisition Reform. 11 National Contract Management Journal27.2 (1996): 43-58...1325-1326. America: History & Life. EBSCO . Web. 10 Apr. 2010. Kraft, Jonathan. 11 The Evolution of Program Budgeting in the United States Government...34 Armed Forces Comptroller 54.1 (2009): 40-41. International Security & Counter Terrorism Reference Center. EBSCO . Web. 11 Apr. 2010. Li, Allen

  14. Evidence of maternal provisioning of alkaloid-based chemical defenses in the strawberry poison frog Oophaga pumilio.

    Science.gov (United States)

    Stynoski, Jennifer L; Torres-Mendoza, Yaritbel; Sasa-Marin, Mahmood; Saporito, Ralph A

    2014-03-01

    Many organisms use chemical defenses to reduce predation risk. Aposematic dendrobatid frogs sequester alkaloid-based chemical defenses from a diet of arthropods, but research on these defenses has been limited to adults. Herein, we investigate chemical defense across development in a dendrobatid frog, Oophaga pumilio. This species displays complex parental care: at hatching, mothers transport tadpoles to phytotelmata, and then return to supply them with an obligate diet of nutritive eggs for about six weeks. We collected eggs, tadpoles, juveniles, and adults of O. pumilio, and detected alkaloids in all life stages. The quantity and number of alkaloids increased with frog and tadpole size. We did not detect alkaloids in the earliest stage of tadpoles, but alkaloids were detected as trace quantities in nutritive eggs and as small quantities in ovarian eggs. Tadpoles hand-reared with eggs of an alkaloid-free heterospecific frog did not contain alkaloids. Alkaloids that are sequestered from terrestrial arthropods were detected in both adults and phytotelm-dwelling tadpoles that feed solely on nutritive eggs, suggesting that this frog may be the first animal known to actively provision post-hatch offspring with chemical defenses. Finally, we provide experimental evidence that maternally derived alkaloids deter predation of tadpoles by a predatory arthropod.

  15. Defense Manufacturing Management Guide for Program Managers, Third Edition

    Science.gov (United States)

    1989-04-01

    producibillty acquisition proce3s. This chapter builds on a programs are Imperative as a management definition of proaticibility and Its relationship to...Identification (ACI), 13-7 functional configuration Identification (FCI), 13-7 item (CI), 13-5 management : definition , 13-5 policies and objectives, 13-7...3-10 human element In, 14-6 management : definition , 1-1, 6-2 documents, 1-7 DOD organizational structure, 1-2 objectives of DOD, 1-1 overview of DOD

  16. No evidence for the induction of brown algal chemical defense by the phytohormones jasmonic acid and methyl jasmonate.

    Science.gov (United States)

    Wiesemeier, Theresa; Jahn, Karsten; Pohnert, Georg

    2008-12-01

    Induced chemical defense reactions are widespread in marine brown algae. Despite the evidence that the biosynthesis of defense metabolites can be up-regulated upon herbivory, we do not know how this regulation of biosynthetic pathways to secondary metabolites is achieved in brown algae. In higher plants, the phytohormone jasmonic acid (JA) is crucial for the mediation of induced chemical defenses, and several findings of this metabolite from marine sources have been reported. We tested the hypothesis that JA or related metabolites play a role in induced brown algal defense. Quantification of oxylipins with a detection limit around 20 ng g(-1) algal tissue did not reveal the presence of JA in the seven examined brown algal species Dictyota dichotoma, Colpomenia peregrina, Ectocarpus fasciculatus, Fucus vesiculosus, Himanthalia elongata, Saccharina latissima (formerly Laminaria saccharina), and Sargassum muticum. Moreover, treatment with ecologically relevant concentrations of JA and methyl jasmonate did not lead to a significant change in the profile of medium- and non-polar metabolites of the tested algae. Only when high concentrations of > or =500 microg ml(-1) medium of the phytohormones were applied that a metabolic response which could be attributed to unspecific stress was observed. Bioassays with D. dichotoma that focused on medium- and non-polar compounds confirmed the lack of a biological role of JA and methyl jasmonate in the induction of algal induced chemical defenses. The phytohormone-treated samples did not exhibit any increased defense potential towards the amphipod Ampithoe longimana and the isopod Paracerceis caudata. JA and related phytohormones, known to be active in higher plants, thus appear to play no role in brown algae for induction of the defense chemicals studied here.

  17. Variation in the expression of chemical defenses in Alliaria petiolata (Brassicaceae) in the field and common garden.

    Science.gov (United States)

    Cipollini, Don

    2002-09-01

    I examined glucosinolates, trypsin inhibitors (TI), and peroxidase (POD) activity in garlic mustard (Alliaria petiolata) plants growing naturally in Wright State University's Forest Preserve and in a common garden experiment in plants from the same populations conducted in the greenhouse. In the field, first-year plants expressed each defense, but defense levels varied significantly in plants from different sites in the forest. Patterns in site variation were consistent for glucosinolate and POD, but not for TI. The TI and POD levels were increased by mechanical wounding, but glucosinolate levels were unaffected. In the greenhouse, plants expressed each defense at higher levels than in the field, but defense levels did not vary among plants collected from each site in the field. The POD activity was increased by wounding, but glucosinolate and TI levels where unaffected. Plants from each site varied in height and leaf length when measured shortly after transplantation, but site differences substantially diminished after 4 wk. Site-based variation in defense expression in the field, which disappeared in the greenhouse, was presumably related to differences in environmental quality among the sites. Sites were shown to vary in soil moisture content, soil pH, nutrient levels, and presumably light quantity or quality. Despite an apparent lack of genetic variation in defense across sites in the field, the constitutive expression of these three chemical defenses, increases due to wounding, and phenotypic variation across sites could reduce herbivore success on garlic mustard individuals and slow the rate of herbivore adaptation to garlic mustard populations.

  18. Chemical defenses of the tropical marine seaweed Canistrocarpus cervicornis against herbivory by sea urchin

    Directory of Open Access Journals (Sweden)

    Éverson Miguel Bianco

    2010-09-01

    Full Text Available This paper reports on the defensive chemical properties of the marine tropical brown seaweed Canistrocarpus cervicornis against herbivory. A natural concentration of dichloromethane crude extract (DCE obtained from this seaweed significantly inhibited feeding by the sea urchin Lytechinus variegatus. The major metabolite isolated from this active DCE extract was identified as the (4R,7R,14S-4α,7α-diacetoxy-14-hydroxydolast-1(15,8-diene that strongly inhibited feeding by the same sea urchin. This result suggests that the dolastane diterpenes class may constitute the defensive system of C. cervicornis against herbivory, and probably also of that of other brown seaweeds endowed with a biosynthetic pathway capable of producing compounds of the dolastane-type, a typical skeleton found in Dyctioteae species worldwide. This is the first report showing this compound-type (dolastane diterpenes as a chemical defense against herbivory in marine seaweeds. This study constitutes an additional report broadening the known spectrum of action and roles of secondary metabolites of the C. cervicornis and Dyctioteae species.Este artigo demonstra a química defensiva anti-herbivoria da macroalga parda marinha Canistrocarpus cervicornis. Em sua concentração natural, o extrato bruto em diclorometano (DCE inibiu significativamente o consumo alimentar do ouriço-do-mar Lytechinus variegatus. Deste extrato em DCE foi isolado o metabólito majoritário identificado como o diterpeno (4R,7R,14S-4α,7α-diacetoxi-14-hidroxidolasta-1(15,8-dieno. Esses resultados comprovam que diterpenos da classe dolastano podem compor o sistema defensivo anti-herbivoria de C. cervircornis e, supostamente, o de outras algas pardas capazes de produzi-los, uma vez que são composto típicos encontrados em esqueletos de Dyctiotas em todo o mundo. Este é o primeiro estudo demonstrando a ação anti-herbivoria desta classe de metabolitos (diterpenos dolastanos em macroalgas marinhas. Tais

  19. National Defense: Department of Defense’s Waiver of Competitive Prototyping Requirement for the Navy’s Fleet Replenishment Oiler Program

    Science.gov (United States)

    2014-10-08

    Defense: Department of Defense’s Waiver of Competitive Prototyping Requirement for the Navy’s Fleet Replenishment Oiler Program The Weapon Systems...Department of Defense’s Waiver of Competitive Prototyping Requirement for the Navy’s Fleet Replenishment Oiler Program 5a. CONTRACT NUMBER 5b. GRANT...15, 2014, we received notice from DOD that it had waived the competitive prototyping requirement for the Fleet Replenishment Oiler (T-AO(X)) program

  20. Department of Defense Chemical and Biological Defense Program. Annual Report to Congress

    Science.gov (United States)

    2008-05-01

    eight mutants of yCE to increase organophosphorous acid anhydrase (OPAA) Achieved up to a 20-fold increase in the • specificity constant for carboxyl...Integrated Product Team or Overarching Integrated Process Team OPAA – Organophosphorous Acid Anhydrase OPCW – Organization for the Prohibition of

  1. Department of Defense Chemical and Biological Defense Program. FY2004-2006 Performance Plan

    Science.gov (United States)

    2005-03-01

    efficacy studies) required for a supplemental New Drug Application for cidofovir and provide technical data and support to the drug license holder...including animal efficacy studies) required for a supplemental New Drug Application for cidofovir and provide technical data and support to the drug...animal efficacy rule. Initiated DoD CBDP Performance Plan 83 FY2004 Targets Actual Performance development of an oral prodrug of cidofovir

  2. Department of Defense Chemical and Biological Defense Program. Volume I: Annual Report to Congress

    Science.gov (United States)

    2002-04-01

    Determined that cowpox is the best choice for a surrogate virus for initial testing of therapeutic compounds. "* Identified the drug cidofovir (HPMPC...established that cidofovir treatment during vaccinia vaccination did not interfere with vaccine protection. "* Determined that cidofovir treatment initiated...inhibition of 32 variola strains in two cell lines by cidofovir . Results were sufficient to support the preclinical section of an IND for intravenous

  3. Department of Defense Chemical, Biological, Radiological, and Nuclear Defense Program. FY2003-2005 Performance Plan

    Science.gov (United States)

    2004-05-01

    Pathogenic Orthopox Viruses (DTO CB54) Determined the optimum dose of cidofovir in the appropriate non- human primate model using both the lethal...efficacy studies) required for a supplemental New Drug Application for cidofovir and provide technical data and support to the drug license holder...efficacy rule. Initiate development of an oral prodrug of cidofovir . Diagnostic Technologies, Methodology to Facilitate Development of Biological

  4. Department of Defense Chemical, Biological, Defense Program, Annual Report to Congress, March 2005

    Science.gov (United States)

    2005-03-01

    including animal efficacy studies) required for a supplemental New Drug Application for cidofovir and provided technical data and support to the drug...animal efficacy rule. • Initiated development of an oral prodrug of cidofovir . • Completed the assessment of the clinical study site to determine...feasibility for use in a field trial of cidofovir to treat human monkeypox. • Completed an initial dose seeking study using an oral form of cidofovir in

  5. Department of Defense Chemical and Biological Defense Programs: DoD Advance Planning Briefing for Industry

    Science.gov (United States)

    2013-05-16

    deadly diseases . We’ll increase funding to help states and communities train and equip our heroic police and firefighters. ” President George W...Tech Development - Adv Dev for CB Prep at Univ of Med & Dentistry of NJ - Miniaturization of CB Detectors - Biodefense Statewide Med Response - Bio...call for a decisive victory in one of those conflicts- including the possibility of regime change or occupation ; and Conduct a limited number of

  6. Department of Defense Joint Chemical and Biological Defense Program 2009 Annual Report to Congress

    Science.gov (United States)

    2009-03-27

    JPM-Decon began fielding the Joint Service Personnel/Skin Decontamination System (JSPDS) with Reactive Skin Decontamination Lotion ( RSDL ). RSDL , an...decontaminate the skin after exposure to CWAs/ BWAs. RSDL supports immediate and thorough personnel decontamination operations—an improved capability...over the existing M291 skin decontaminating kit. RSDL neutralizes, as opposed to removing, the agent. Additionally, it can be used to decontaminate

  7. 2010 Department of Defense (DoD) Chemical and Biological Defense Program (CBDP) Portfolio

    Science.gov (United States)

    2010-03-01

    Lotion ( RSDL ) N/A 6505-01-507-5074/ 6910-01-507-5141 03-881/03-0882 N/A DLA 8 • Super Tropical Bleach (STB) N/A 6850-00-297-6653 N/A N/A DLA 3 Kits... RSDL ) .................................................122 Rotary Wing (RW

  8. Department of Defense Chemical and Biological Defense Program. Volume 2: FY2001-2003 Performance Plan

    Science.gov (United States)

    2002-04-01

    translocation domains of the botulinum neurotoxins. Investigate the variability of clostridium botu- linum strains in terms of their neurotoxic...protective immunity in mice against neurotoxins produced by various strains of Clostridium botulinum. Viral Vaccines - Define the correlates of immunity...with next generation nerve agent scavengers. Continue development of potential transgenic /bioengineered sources of next generation nerve agent

  9. Department of Defense Chemical and Biological Defense Program. FY2002-2004 Performance Plan. Volume 2

    Science.gov (United States)

    2003-04-01

    ability to protect against filoviruses (Marburg and Ebola viruses). Complete research studies for the development of vaccine candidates for WEE...identify novel antigens that show protection in mice against at least two encephalitic alphaviruses. Continue research for the development of vaccine candidates

  10. Environmental evaluation of alternatives for long-term management of Defense high-level radioactive wastes at the Idaho Chemical Processing Plant

    Energy Technology Data Exchange (ETDEWEB)

    1982-09-01

    The U.S. Department of Energy (DOE) is considering the selection of a strategy for the long-term management of the defense high-level wastes at the Idaho Chemical Processing Plant (ICPP). This report describes the environmental impacts of alternative strategies. These alternative strategies include leaving the calcine in its present form at the Idaho National Engineering Laboratory (INEL), or retrieving and modifying the calcine to a more durable waste form and disposing of it either at the INEL or in an offsite repository. This report addresses only the alternatives for a program to manage the high-level waste generated at the ICPP. 24 figures, 60 tables.

  11. The NIH Countermeasures Against Chemical Threats Program: overview and special challenges.

    Science.gov (United States)

    Jett, David A

    2016-06-01

    Intentional exposures to toxic chemicals can stem from terrorist attacks, such as the release of sarin in the Tokyo subway system in 1995, as well as from toxic industrial accidents that are much more common. Developing effective medical interventions is a critical component of the overall strategy to overcome the challenges of chemical emergencies. These challenges include the rapid and lethal mode of action of many toxic chemicals that require equally fast-acting therapies, the large number of chemicals that are considered threats, and the diverse demographics and vulnerabilities of those who may be affected. In addition, there may be long-term deleterious effects in survivors of a chemical exposure. Several U.S. federal agencies are invested in efforts to improve preparedness and response capabilities during and after chemical emergencies. For example, the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) Program supports investigators who are developing therapeutics to reduce mortality and morbidity from chemical exposures. The program awards grants to individual laboratories and includes contract resource facilities and interagency agreements with Department of Defense laboratories. The range of high-quality research within the NIH CounterACT Program network is discussed.

  12. Managing the Service Supply Chain in Department of Defense: Implications for the Program Management Infrastructure

    Science.gov (United States)

    2007-04-30

    Supply Chain in Department of Defense: Implications for the Program Management Infrastructure Published: 30 April 2007 by Rene G. Rendon, Lecturer, and Uday Apte, Professor, Naval Postgraduate School 4th Annual Acquisition Research Symposium of the Naval Postgraduate School: Approved for public release, distribution unlimited. Prepared for: Naval Postgraduate School, Monterey, California 93943 Acquisition Research: Creating Synergy for Informed Change May 16-17, 2007 Report Documentation Page Form ApprovedOMB No. 0704-0188

  13. Analysis of System Training Impact for Major Defense Acquisition Programs (MDAPs): Training Systems Acquisition

    Science.gov (United States)

    2012-07-01

    evidenced in our other case studies. However, with the rapid production and deployment of the vehicles in 2007–2008, the operators began to experience...Background The Patriot system began because of the need to replace an aging and limited air defense system in the 1970s, the Nike -Hercules, and...The program sponsors of the Patriot also desired to take advantage of technological innovation and information superiority to enhance overall

  14. Sandia National Laboratories, California Chemical Management Program annual report.

    Energy Technology Data Exchange (ETDEWEB)

    Brynildson, Mark E.

    2012-02-01

    The annual program report provides detailed information about all aspects of the Sandia National Laboratories, California (SNL/CA) Chemical Management Program. It functions as supporting documentation to the SNL/CA Environmental Management System Program Manual. This program annual report describes the activities undertaken during the calender past year, and activities planned in future years to implement the Chemical Management Program, one of six programs that supports environmental management at SNL/CA. SNL/CA is responsible for tracking chemicals (chemical and biological materials), providing Material Safety Data Sheets (MSDS) and for regulatory compliance reporting according to a variety of chemical regulations. The principal regulations for chemical tracking are the Emergency Planning Community Right-to-Know Act (EPCRA) and the California Right-to-Know regulations. The regulations, the Hazard Communication/Lab Standard of the Occupational Safety and Health Administration (OSHA) are also key to the CM Program. The CM Program is also responsible for supporting chemical safety and information requirements for a variety of Integrated Enabling Services (IMS) programs primarily the Industrial Hygiene, Waste Management, Fire Protection, Air Quality, Emergency Management, Environmental Monitoring and Pollution Prevention programs. The principal program tool is the Chemical Information System (CIS). The system contains two key elements: the MSDS library and the chemical container-tracking database that is readily accessible to all Members of the Sandia Workforce. The primary goal of the CM Program is to ensure safe and effective chemical management at Sandia/CA. This is done by efficiently collecting and managing chemical information for our customers who include Line, regulators, DOE and ES and H programs to ensure compliance with regulations and to streamline customer business processes that require chemical information.

  15. Determination of the capabilities of a detachment for neutralizing chemical attack effects in the brigade defense zone

    Directory of Open Access Journals (Sweden)

    Dejan R. Inđić

    2012-04-01

    Full Text Available This paper presents one possible way of deploying detachments for neutralizing the effects of chemical attacks in a brigade defense zone. The detachment composition is provisional and depends on the assessment of whether the enemy in the incoming combat will use weapons of mass destruction. A detachment consists of several organizational units: medical care forces, chemical reconnaissance forces, forces for the establishment of combat efficiency and chemical decontamination forces. The capabilities of the mentioned forces depend on their size, equipment, training level, extent of effects and combat conditions. The paper indicates a potential to overcome the gap in the provisions after disbanding the Army Corps.

  16. Activation of chemical biological defense mechanisms and remission of vital oxidative injury by low dose radiation

    Energy Technology Data Exchange (ETDEWEB)

    Yamaoka, K. [Okayama University Medical School, Okayama (Japan); Nomura, T. [Central Research Institute of Electric Power Industry, Tokyo (Japan); Kojima, S. [Science University of Tokyo, Chiba (Japan)

    2000-05-01

    Excessive active oxygen produced in vivo by various causes is toxic. Accumulation of oxidation injuries due to excessive active causes cell and tissue injuries, inducing various pathologic conditions such as aging and carcinogenesis. On the other hand, there are chemical defense mechanisms in the body that eliminate active oxygen or repair damaged molecules, defending against resultant injury. It is interesting reports that appropriate oxidation stress activate the chemical biological defense mechanisms. In this study, to elucidate these phenomena and its mechanism by low dose radiation, we studied on the below subjects. Activation of chemical biological defense mechanisms by low dose radiation: (1) The effects radiation on lipid peroxide (LPO) levels in the organs, membrane fluidity and the superoxide dismutase (SOD) activity were examined in rats and rabbits. Rats were irradiated with low dose X-ray over their entire bodies, and rabbits inhaled vaporized radon spring water, which primarily emitted {alpha}-ray. The following results were obtained. Unlike high dose X-ray, low dose X-ray and radon inhalation both reduced LPO levels and made the state of the SH-group on membrane-bound proteins closer to that of juvenile animals, although the sensitivity to radioactivity varied depending on the age of the animals and among different organs and tissues. The SOD activity was elevated, suggesting that low dose X-ray and radon both activate the host defensive function. Those changes were particularly marked in the organs related to immune functions of the animals which received low dose X-ray, while they were particularly marked in the brain after radon inhalation. It was also found that those changes continued for longer periods after low dose X-irradiation. (2) Since SOD is an enzyme that mediates the dismutation of O{sub 2}- to H{sub 2}O{sub 2}, the question as to whether the resultant H{sub 2}O{sub 2} is further detoxicated into H{sub 2}O and O{sub 2} or not must

  17. Unveiling chemical defense in the rice stalk stink bug against the entomopathogenic fungus Metarhizium anisopliae.

    Science.gov (United States)

    da Silva, Rodrigo Alves; Quintela, Eliane Dias; Mascarin, Gabriel Moura; Pedrini, Nicolás; Lião, Luciano Moraes; Ferri, Pedro Henrique

    2015-05-01

    Eggs, nymphs (1st-5th instar) and adults of Tibraca limbativentris were challenged by conidial suspensions of its major fungal pathogen Metarhizium anisopliae in order to assess their susceptibility. The role of chemical defensive compounds from exocrine secretions produced by both nymphs and adults were examined for their participation on M. anisopliae infection. Although insect susceptibility to M. anisopliae followed a dose-dependent manner, adults followed by older nymphs displayed the highest resistance. Eggs were highly susceptible showing >96% fungal infection. Crude extracts isolated from metathoracic scent gland and dorsal abdominal glands of adults and nymphs, respectively, showed fungistatic effects by impairing spore germination, vegetative growth and sporulation. Gas chromatography-mass spectrometry analysis of these extracts revealed that the major components were short-chain hydrocarbons (C10-13) and unsaturated aldehydes. In vitro tests with the corresponding synthetic standards indicated compounds with greater antifungal activity including (E)-2-hexenal, (E)-2-octenal, and (E)-2-decenal, with the latter being the most deleterious to fungal fitness. We demonstrated that differential susceptibility of the rice stalk stink bug to M. anisopliae infection is age-specific and partly mediated by fungistatic properties of aldehydes, which are produced by scent glands of both nymphs and adults.

  18. Survey of Laboratories and Implementation of the Federal Defense Laboratory Diversification Program

    Science.gov (United States)

    1994-02-01

    Defense Technology Transfer Working Group AGENCY...Director, Defense Research and Engineering. ACTION: solicitation in inputs for defense technology transfer . The Defense Technology Transfer Working...DAILY, 2.3 July 1993 Detense Nuclear Agency, 6801 Telegraph Road, Alexandria,, VA 22310D-3398 A - SOURCES SOUGHT FOR INPUTS FOR DEFENSE TECHNOLOGY TRANSFER

  19. Seasonal fluctuations in chemical defenses against macrofouling in Fucus vesiculosus and Fucus serratus from the Baltic Sea.

    Science.gov (United States)

    Rickert, Esther; Karsten, Ulf; Pohnert, Georg; Wahl, Martin

    2015-01-01

    Macroalgae, especially perennial species, are exposed to a seasonally variable fouling pressure. It was hypothesized that macroalgae regulate their antifouling defense to fouling pressure. Over one year, the macrofouling pressure and the chemical anti-macrofouling defense strength of the brown algae Fucus vesiculosus and Fucus serratus were assessed with monthly evaluation. The anti-macrofouling defense was assessed by means of surface-extracted Fucus metabolites tested at near-natural concentrations in a novel in situ bioassay. Additionally, the mannitol content of both Fucus species was determined to assess resource availability for defense production. The surface chemistry of both Fucus species exhibited seasonal variability in attractiveness to Amphibalanus improvisus and Mytilus edulis. Of this variability, 50-60% is explained by a sinusoidal model. Only F. vesiculosus extracts originating from the spring and summer significantly deterred settlement of A. improvisus. The strength of macroalgal antifouling defense did not correlate either with in situ macrofouling pressure or with measured mannitol content, which, however, were never depleted.

  20. Chemical Defenses (Glucosinolates) of Native and Invasive Populations of the Range Expanding Invasive Plant Rorippa austriaca

    NARCIS (Netherlands)

    Huberty, M.; Tielborger, K.; Harvey, J.A.; Muller, C.; Macel, M.

    2014-01-01

    Due to global warming, species are expanding their range to higher latitudes. Some range expanding plants have become invasive in their new range. The Evolution of Increased Competitive Ability (EICA) hypothesis and the Shifting Defense Hypothesis (SDH) predict altered selection on plant defenses in

  1. Engineering the Business of Defense Acquisition: An Analysis of Program Office Processes

    Science.gov (United States)

    2015-04-30

    This constant change also affects the technical staff. Uncertainty is reflected in another complexity factor , socio- political (Maier, 1995). It is this...communication. While a known factor , this communication causes considerable work not directly related to managing technical development. The politics of...ååì~ä=^Åèìáëáíáçå= oÉëÉ~êÅÜ=póãéçëáìã= tÉÇåÉëÇ~ó=pÉëëáçåë= sçäìãÉ=f= = Engineering the Business of Defense Acquisition: An Analysis of Program Office

  2. Defense Waste Processing Facility Simulant Chemical Processing Cell Studies for Sludge Batch 9

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Tara E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Newell, J. David [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Woodham, Wesley H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-08-10

    The Savannah River National Laboratory (SRNL) received a technical task request from Defense Waste Processing Facility (DWPF) and Saltstone Engineering to perform simulant tests to support the qualification of Sludge Batch 9 (SB9) and to develop the flowsheet for SB9 in the DWPF. These efforts pertained to the DWPF Chemical Process Cell (CPC). CPC experiments were performed using SB9 simulant (SB9A) to qualify SB9 for sludge-only and coupled processing using the nitric-formic flowsheet in the DWPF. Two simulant batches were prepared, one representing SB8 Tank 40H and another representing SB9 Tank 51H. The simulant used for SB9 qualification testing was prepared by blending the SB8 Tank 40H and SB9 Tank 51H simulants. The blended simulant is referred to as SB9A. Eleven CPC experiments were run with an acid stoichiometry ranging between 105% and 145% of the Koopman minimum acid equation (KMA), which is equivalent to 109.7% and 151.5% of the Hsu minimum acid factor. Three runs were performed in the 1L laboratory scale setup, whereas the remainder were in the 4L laboratory scale setup. Sludge Receipt and Adjustment Tank (SRAT) and Slurry Mix Evaporator (SME) cycles were performed on nine of the eleven. The other two were SRAT cycles only. One coupled flowsheet and one extended run were performed for SRAT and SME processing. Samples of the condensate, sludge, and off-gas were taken to monitor the chemistry of the CPC experiments.

  3. Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system.

    Science.gov (United States)

    Chang, Shiao-Ying; Chen, Yun-Wen; Zhao, Xin-Ping; Chenier, Isabelle; Tran, Stella; Sauvé, Alexandre; Ingelfinger, Julie R; Zhang, Shao-Ling

    2012-10-01

    We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes. Male offspring of nondiabetic and diabetic dams from two transgenic (Tg) lines (Hoxb7-green fluorescent protein [GFP]-Tg [controls] and Hoxb7/CAT-GFP-Tg, which overexpress CAT in RPTCs) were studied from the prenatal period into adulthood. Nephrogenesis, systolic blood pressure, renal hyperfiltration, kidney injury, and reactive oxygen species (ROS) generation were assessed. Gene expression of transforming growth factor-β1 (TGF-β1), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and heme oxygenase-1 (HO-1) was tested in both in vitro and in vivo studies. Renal dysmorphogenesis was observed in offspring of Hoxb7-GFP-Tg dams with severe maternal diabetes; the affected male offspring displayed higher renal ROS generation and developed hypertension and renal hyperfiltration as well as renal injury with heightened TGF-β1 expression in adulthood. These changes were ameliorated in male offspring of diabetic Hoxb7/CAT-GFP-Tg dams via the Nrf2-HO-1 defense system. CAT promoted Nrf2 nuclear translocation and HO-1 gene expression, seen in both in vitro and in vivo studies. In conclusion, CAT overexpression in the RPTCs ameliorated maternal diabetes-induced perinatal programming, mediated, at least in part, by triggering the Nrf2-HO-1 defense system.

  4. Two brominated cyclic dipeptides released by the coldwater marine sponge Geodia barretti act in synergy as chemical defense.

    Science.gov (United States)

    Sjögren, Martin; Jonsson, Per R; Dahlström, Mia; Lundälv, Tomas; Burman, Robert; Göransson, Ulf; Bohlin, Lars

    2011-03-25

    The current work shows that two structurally similar cyclodipeptides, barettin (1) and 8,9-dihydrobarettin (2), produced by the coldwater marine sponge Geodia barretti Bowerbank act in synergy to deter larvae of surface settlers and may also be involved in defense against grazers. Previously, 1 and 2 were demonstrated to bind specifically to serotonergic 5-HT receptors. It may be suggested that chemical defense in G. barretti involves a synergistic action where one of the molecular targets is a 5-HT receptor. A mixture of 1 and 2 lowered the EC(50) of larval settlement as compared to the calculated theoretical additive effect of the two compounds. Moreover, an in situ sampling at 120 m depth using a remotely operated vehicle revealed that the sponge releases these two compounds to the ambient water. Thus, it is suggested that the synergistic action of 1 and 2 may benefit the sponge by reducing the expenditure of continuous production and release of its chemical defense substances. Furthermore, a synergistic action between structurally closely related compounds produced by the same bioenzymatic machinery ought to be the most energy effective for the organism and, thus, is more common than synergy between structurally indistinct compounds.

  5. Building Partner Capacity: DOD Should Improve Its Reporting to Congress on Challenges to Expanding Ministry of Defense Advisors Program

    Science.gov (United States)

    2015-02-11

    Ministry of Defense Advisors ( MODA ) program more slowly than planned. It had 2 advisors in the field in Kosovo and Montenegro for most of fiscal year...approval process and with advisor recruitment and training. DOD has met most but not all legislative requirements for the MODA program. As required by...of each Global MODA deployment, which could help Congress assess the value of the program in relation to other capacity-building efforts (see figure

  6. US Army Public Health Command’s (Prov) (Formly USACHPPM) Process to Screen Chemicals in Support of DoD’s CMRM Emerging Contaminants Program

    Science.gov (United States)

    2010-06-01

    US Army Public Health Command’s (Prov) (Formly USACHPPM) Process to Screen Chemicals in Support of DoD’s CMRM Emerging Contaminants Program...CMRM Emerging Contaminants Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER...Occupational Health • DoD Instruction 5000.2 Operation of the Defense Acquisition System • DoD Instruction 4715.18 Emerging Contaminants (EC

  7. National toxicology program chemical nomination and selection process

    Energy Technology Data Exchange (ETDEWEB)

    Selkirk, J.K. [National Institute of Environmental Health Sciences, Research Triangle Park, NC (United States)

    1990-12-31

    The National Toxicology Program (NTP) was organized to support national public health programs by initiating research designed to understand the physiological, metabolic, and genetic basis for chemical toxicity. The primary mandated responsibilities of NTP were in vivo and vitro toxicity testing of potentially hazardous chemicals; broadening the spectrum of toxicological information on known hazardous chemicals; validating current toxicological assay systems as well as developing new and innovative toxicity testing technology; and rapidly communicating test results to government agencies with regulatory responsibilities and to the medical and scientific communities. 2 figs.

  8. Variability in chemical defense across a shallow to mesophotic depth gradient in the Caribbean sponge Plakortis angulospiculatus

    Science.gov (United States)

    Slattery, Marc; Gochfeld, Deborah J.; Diaz, M. Cristina; Thacker, Robert W.; Lesser, Michael P.

    2016-03-01

    The transition between shallow and mesophotic coral reef communities in the tropics is characterized by a significant gradient in abiotic and biotic conditions that could result in potential trade-offs in energy allocation. The mesophotic reefs in the Bahamas and the Cayman Islands have a rich sponge fauna with significantly greater percent cover of sponges than in their respective shallow reef communities, but relatively low numbers of spongivores. Plakortis angulospiculatus, a common sponge species that spans the depth gradient from shallow to mesophotic reefs in the Caribbean, regenerates faster following predation and invests more energy in protein synthesis at mesophotic depths compared to shallow reef conspecifics. However, since P. angulospiculatus from mesophotic reefs typically contain lower concentrations of chemical feeding deterrents, they are not able to defend new tissue from predation as efficiently as conspecifics from shallow reefs. Nonetheless, following exposure to predators on shallow reefs, transplanted P. angulospiculatus from mesophotic depths developed chemical deterrence to predatory fishes. A survey of bioactive extracts indicated that a specific defensive metabolite, plakortide F, varied in concentration with depth, producing altered deterrence between shallow and mesophotic reef P. angulospiculatus. Different selective pressures in shallow and mesophotic habitats have resulted in phenotypic plasticity within this sponge species that is manifested in variable chemical defense and tissue regeneration at wound sites.

  9. Microfiche/Telex Oriented Document Services Center Established in Sylvania Library Through Cooperative Test Program with Defense Documentation Center.

    Science.gov (United States)

    Little, Dean K.

    In a cooperative program with Defense Documentation Center Headquarters, Sylvania arranged for procurement of 70,000 unclassified-unlimited documents without DDC Form I cards and 30,000 unclassified-limited and classified documents with Form I's. This was done in order to overcome effects of an in-house documents inventory/selective destruction…

  10. Preparing for a Nightmare: USNORTHCOM’S Homeland Defense Mission Against Chemical and Biological Attack

    Science.gov (United States)

    2014-05-15

    radiological and nuclear defense. 3 The United States is not secure. The borders between Mexico and Canada are largely unmonitored and illicit...weapons. Commercial air travel may be mostly secured since September 11, 2001, but that does not preclude nefarious actions utilizing non- commercial...Rising rates of antibiotic resistant bacteria or “superbugs,” threaten to cause an epidemic stemming from previously treatable diseases. 19 Viruses are

  11. Innovative Science and Technology, Ballistic Missile Defense Organization, Technical Program Information.

    Science.gov (United States)

    2007-11-02

    will be encouraged to follow-up with additional documentation - for example, a white paper or formal proposal. In addition to basic program efforts...related devices for opto-electronics, double heterostructures composed of AlGaN, GaN, and InGaN based layers for laser diode applications, as well...emitting diode ( LED ) structures. Opportunities Unique chemical approaches for ultra-fast EO external modulators; opto-electronic, ultra-high-speed signal

  12. [Systematically induced effects of Tetranychus cinnabarinus infestation on chemical defense in Zea mays inbred lines].

    Science.gov (United States)

    Zhu, Yu-xi; Yang, Qun-fang; Huang, Yu-bi; Li, Qing

    2015-09-01

    In the present study, we investigated the systematically induced production of defense-related compounds, including DIMBOA, total phenol, trypsin inhibitors (TI) and chymotrypsin inhibitor (CI), by Tetranychus cinnabarinus infestation in Zea mays. The first leaves of two corn in-bred line seedlings, the mite-tolerant line ' H1014168' and the mite-sensitive line 'H1014591', were sucked by T. cinnabarinus adult female for seven days, and then the contents of DIMBOA, total phenol, TI and CI were measured in the second leaf and in the roots, respectively. Results showed that as compared to the unsucked control, all contents of DIMBOA, total phenol, TI and CI induced by T. cinnabarinus sucking were significantly higher in the second leaf of both inbred lines as well as in the roots of the mite-tolerant 'H1014168'. However, in the roots of 'H1014591', these defense compounds had different trends, where there was a higher induction of TI and a lower level of total phenol than that of the healthy control, while had almost no difference in DIMBOA and CI. These findings suggested that the infestation of T. cinnabarinus could systematically induce accumulation of defense-related compounds, and this effect was stronger in the mite-tolerant inbred line than in the mite-sensitive inbred line.

  13. 77 FR 8837 - Termination of the Department of Defense Web-Based TRICARE Assistance Program Demonstration

    Science.gov (United States)

    2012-02-15

    ... family difficulties and pressures, crisis intervention, anxiety, self-esteem, loneliness, and critical... Demonstration AGENCY: Department of Defense, DoD. ACTION: Notice of demonstration termination. SUMMARY:...

  14. THE PLANNING, PROGRAMING, BUDGETING SYSTEM AND ITS IMPLEMENTATION IN THE SERBIAN MINISTRY OF DEFENSE

    Directory of Open Access Journals (Sweden)

    Sasa RADUSKI

    2010-01-01

    Full Text Available The main purpose of introducing the PPBES to the Serbian Ministry of Defense and the Serbian Armed Forces is to provide a rational management of resources and to maintain and build capacity of the Ministry and the Serbian Armed Forces in order to achieve their goals, objectives and missions.Expected results of implementation of the PPBES are reflected in increasing the efficiency and rationalization of the defense planning to a higher level, ensuring compatibility with defense planning and budgeting system of the state and developing a foundation for the effective management of defense resources.

  15. Review of Catalytic Hydrogen Generation in the Defense Waste Processing Facility (DWPF) Chemical Processing Cell

    Energy Technology Data Exchange (ETDEWEB)

    Koopman, D. C.

    2004-12-31

    This report was prepared to fulfill the Phase I deliverable for HLW/DWPF/TTR-98-0018, Rev. 2, ''Hydrogen Generation in the DWPF Chemical Processing Cell'', 6/4/2001. The primary objective for the preliminary phase of the hydrogen generation study was to complete a review of past data on hydrogen generation and to prepare a summary of the findings. The understanding was that the focus should be on catalytic hydrogen generation, not on hydrogen generation by radiolysis. The secondary objective was to develop scope for follow-up experimental and analytical work. The majority of this report provides a summary of past hydrogen generation work with radioactive and simulated Savannah River Site (SRS) waste sludges. The report also includes some work done with Hanford waste sludges and simulants. The review extends to idealized systems containing no sludge, such as solutions of sodium formate and formic acid doped with a noble metal catalyst. This includes general information from the literature, as well as the focused study done by the University of Georgia for the SRS. The various studies had a number of points of universal agreement. For example, noble metals, such as Pd, Rh, and Ru, catalyze hydrogen generation from formic acid and formate ions, and more acid leads to more hydrogen generation. There were also some points of disagreement between different sources on a few topics such as the impact of mercury on the noble metal catalysts and the identity of the most active catalyst species. Finally, there were some issues of potential interest to SRS that apparently have not been systematically studied, e.g. the role of nitrite ion in catalyst activation and reactivity. The review includes studies covering the period from about 1924-2002, or from before the discovery of hydrogen generation during simulant sludge processing in 1988 through the Shielded Cells qualification testing for Sludge Batch 2. The review of prior studies is followed by a

  16. Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agencies Abstracts of Phase 1 Awards 1987.

    Science.gov (United States)

    1988-04-01

    CHANNEL) . THE -0 SMALL BUSINESS INNOVATION RESEARCH ( SBR ) PROGRAM - PHASE I PAGE 628 0 BY SERVICE FISCAL YEAR 1987 DNA SJBMTTFD BY NATURE OF THE...OXYGEN CONTAMINATION. THEIR HIGH PYROLYSIS TEMPERATURES CAUSE PROBLEMS SUCH AS INABILITY TO CONTROL THE AS/P RATIO IN ALLOYS CONTAINING BOTH ELEMENTS...LUBRICITY. GRAPHITE FIBER GROWN FROM PYROLYSIS OF HYDROCARBON GAS, WHICH IS THEN PROCESSED TO YIELD USEFUL VALUES FOR ELECTRICAL CONDUCTIVITY, IS A MATERIAL

  17. Planning guidance for the Chemical Stockpile Emergency Preparedness Program

    Energy Technology Data Exchange (ETDEWEB)

    Shumpert, B.L.; Watson, A.P.; Sorensen, J.H. [and others

    1995-02-01

    This planning guide was developed under the direction of the U.S. Army and the Federal Emergency Management Agency (FEMA) which jointly coordinate and direct the development of the Chemical Stockpile Emergency Preparedness Program (CSEPP). It was produced to assist state, local, and Army installation planners in formulating and coordinating plans for chemical events that may occur at the chemical agent stockpile storage locations in the continental United States. This document provides broad planning guidance for use by both on-post and off-post agencies and organizations in the development of a coordinated plan for responding to chemical events. It contains checklists to assist in assuring that all important aspects are included in the plans and procedures developed at each Chemical Stockpile Disposal Program (CSDP) location. The checklists are supplemented by planning guidelines in the appendices which provide more detailed guidance regarding some issues. The planning guidance contained in this document will help ensure that adequate coordination between on-post and off-post planners occurs during the planning process. This planning guide broadly describes an adequate emergency planning base that assures that critical planning decisions will be made consistently at every chemical agent stockpile location. This planning guide includes material drawn from other documents developed by the FEMA, the Army, and other federal agencies with emergency preparedness program responsibilities. Some of this material has been developed specifically to meet the unique requirements of the CSEPP. In addition to this guidance, other location-specific documents, technical studies, and support studies should be used as needed to assist in the planning at each of the chemical agent stockpile locations to address the specific hazards and conditions at each location.

  18. Influence of Genotype, Environment, and Gypsy Moth Herbivory on Local and Systemic Chemical Defenses in Trembling Aspen (Populus tremuloides).

    Science.gov (United States)

    Rubert-Nason, Kennedy F; Couture, John J; Major, Ian T; Constabel, C Peter; Lindroth, Richard L

    2015-07-01

    Numerous studies have explored the impacts of intraspecific genetic variation and environment on the induction of plant chemical defenses by herbivory. Relatively few, however, have considered how those factors affect within-plant distribution of induced defenses. This work examined the impacts of plant genotype and soil nutrients on the local and systemic phytochemical responses of trembling aspen (Populus tremuloides) to defoliation by gypsy moth (Lymantria dispar). We deployed larvae onto foliage on individual tree branches for 15 days and then measured chemistry in leaves from: 1) branches receiving damage, 2) undamaged branches of insect-damaged trees, and 3) branches of undamaged control trees. The relationship between post-herbivory phytochemical variation and insect performance also was examined. Plant genotype, soil nutrients, and damage all influenced phytochemistry, with genotype and soil nutrients being stronger determinants than damage. Generally, insect damage decreased foliar nitrogen, increased levels of salicinoids and condensed tannins, but had little effect on levels of a Kunitz trypsin inhibitor, TI3. The largest damage-mediated tannin increases occurred in leaves on branches receiving damage, whereas the largest salicinoid increases occurred in leaves of adjacent, undamaged branches. Foliar nitrogen and the salicinoid tremulacin had the strongest positive and negative relationships, respectively, with insect growth. Overall, plant genetics and environment concomitantly influenced both local and systemic phytochemical responses to herbivory. These findings suggest that herbivory can contribute to phytochemical heterogeneity in aspen foliage, which may in turn influence future patterns of herbivory and nutrient cycling over larger spatial scales.

  19. 48th Canadian Chemical Engineering conference: technical program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    This is the official CD-ROM for the Canadian Society for Chemical Engineering annual conference. The documents on the disk can be navigated in the same way as a Web site on the Internet. Web pages are located on the disk. A Web browser is required to view most of the files. The conference program contains abstracts of the more than 300 papers presented at 78 sessions covering all aspects of chemical engineering: fluidized bed, reaction catalysis, environment, new developments, biotechnology, process control, polymers, fluid mechanics, pulp and paper, thermodynamics, multiphase reactors, reaction catalysis, rheology, chemical engineering fundamentals, chemical technology, oil and gas, education, and industrial issues. Five of the abstracts have been abstracted separately.

  20. Compilation of demographic data for the chemical stockpile emergency preparedness program

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, B.; Sorensen, J.; Coomer, C. [Oak Ridge National Lab., TN (United States); Shumpert, B.; Hardee, H. [Univ. of Tennessee, Knoxville, TN (United States)

    1998-01-01

    There are eight installations in the continental US where lethal unitary chemical agents and munitions have been stored since the late 1950`s. In December, 1985, Congress directed the Department of Defense (DOD) to destroy these stockpiles of aging chemical warfare weapons. The destruction was to take place in such a manner as to provide: (1) maximum protection of the environment, the general public, and the personnel involved in the destruction, (2) adequate and safe facilities designed solely for the destruction of the stockpile, and (3) clean-up dismantling, and disposal of the facilities when the disposal program was complete. To help communities develop emergency response capabilities, the Army established the Chemical Stockpile Emergency Preparedness Program or CSEPP based on principals established in the Emergency Response Concept Plan (ERCP). The Army and the Federal Emergency Management Agency (FEMA) jointly oversee the CSEPP. An important part of the ERCP guidance was establishing cooperative interaction between local, state, and federal agencies and the development of emergency planning zones (EPZs) to support the emergency response concept. The purpose of this document is to describe how the population figures were derived for the population estimates for both the Chemical Stockpile Disposal Program and the CSEPP analyses. Most of the data is derived from the US Census 1990 population figures. However, the Census only counts residential populations and does not attempt to document daytime populations within commercial or residential facilities. One conclusion from this review is that there is a need for better and more consistent population data in the Emergency Planning Guides.

  1. Chemical and mechanical defenses vary among maternal lines and leaf ages in Verbascum thapsus L. (Scrophulariaceae and reduce palatability to a generalist insect.

    Directory of Open Access Journals (Sweden)

    Christina Alba

    Full Text Available Intra-specific variation in host-plant quality affects herbivore foraging decisions and, in turn, herbivore foraging decisions mediate plant fitness. In particular, variation in defenses against herbivores, both among and within plants, shapes herbivore behavior. If variation in defenses is genetically based, it can respond to natural selection by herbivores. We quantified intra-specific variation in iridoid glycosides, trichome length, and leaf strength in common mullein (Verbascum thapsus L, Scrophulariaceae among maternal lines within a population and among leaves within plants, and related this variation to feeding preferences of a generalist herbivore, Trichopulsia ni Hübner. We found significant variation in all three defenses among maternal lines, with T. ni preferring plants with lower investment in chemical, but not mechanical, defense. Within plants, old leaves had lower levels of all defenses than young leaves, and were strongly preferred by T. ni. Caterpillars also preferred leaves with trichomes removed to leaves with trichomes intact. Differences among maternal lines indicate that phenotypic variation in defenses likely has a genetic basis. Furthermore, these results reveal that the feeding behaviors of T. ni map onto variation in plant defense in a predictable way. This work highlights the importance of variation in host-plant quality in driving interactions between plants and their herbivores.

  2. APOLLO: A computer program for the calculation of chemical equilibrium and reaction kinetics of chemical systems

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, H.D.

    1991-11-01

    Several of the technologies being evaluated for the treatment of waste material involve chemical reactions. Our example is the in situ vitrification (ISV) process where electrical energy is used to melt soil and waste into a ``glass like`` material that immobilizes and encapsulates any residual waste. During the ISV process, various chemical reactions may occur that produce significant amounts of products which must be contained and treated. The APOLLO program was developed to assist in predicting the composition of the gases that are formed. Although the development of this program was directed toward ISV applications, it should be applicable to other technologies where chemical reactions are of interest. This document presents the mathematical methodology of the APOLLO computer code. APOLLO is a computer code that calculates the products of both equilibrium and kinetic chemical reactions. The current version, written in FORTRAN, is readily adaptable to existing transport programs designed for the analysis of chemically reacting flow systems. Separate subroutines EQREACT and KIREACT for equilibrium ad kinetic chemistry respectively have been developed. A full detailed description of the numerical techniques used, which include both Lagrange multiplies and a third-order integrating scheme is presented. Sample test problems are presented and the results are in excellent agreement with those reported in the literature.

  3. APOLLO: A computer program for the calculation of chemical equilibrium and reaction kinetics of chemical systems

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, H.D.

    1991-11-01

    Several of the technologies being evaluated for the treatment of waste material involve chemical reactions. Our example is the in situ vitrification (ISV) process where electrical energy is used to melt soil and waste into a glass like'' material that immobilizes and encapsulates any residual waste. During the ISV process, various chemical reactions may occur that produce significant amounts of products which must be contained and treated. The APOLLO program was developed to assist in predicting the composition of the gases that are formed. Although the development of this program was directed toward ISV applications, it should be applicable to other technologies where chemical reactions are of interest. This document presents the mathematical methodology of the APOLLO computer code. APOLLO is a computer code that calculates the products of both equilibrium and kinetic chemical reactions. The current version, written in FORTRAN, is readily adaptable to existing transport programs designed for the analysis of chemically reacting flow systems. Separate subroutines EQREACT and KIREACT for equilibrium ad kinetic chemistry respectively have been developed. A full detailed description of the numerical techniques used, which include both Lagrange multiplies and a third-order integrating scheme is presented. Sample test problems are presented and the results are in excellent agreement with those reported in the literature.

  4. Data Science at the Defense Personnel and Security Research Center. Mission: Improve the Effectiveness, Efficiency, and Fairness of DoD Personnel Security and Suitability Programs

    Science.gov (United States)

    2015-05-14

    policy and operational challenges. Data Science : Current Initiatives 4 UNCLASSIFIED Data Science Hadoop cluster projects since 2013, e.g...Defense Personnel and Security Research Center Data Science at the Defense Personnel and Security Research Center Serving Those Who Serve Our...Mission: Improve the Effectiveness, Efficiency, and Fairness of DoD Personnel Security and Suitability Programs Report Documentation Page Form

  5. Department of Defense Small Business (SB) Program: A Knowledge-Level Analysis of How Customer Education Relates to Meeting SB Goals

    Science.gov (United States)

    2014-12-01

    7 B. SMALL BUSINESS PROGRAM OVERVIEW ...........................................7 1. Women -Owned Small ...of Defense DSB Director of Small Business DTRA Defense Threat Reduction Agency EDWOSB economically disadvantaged women -owned small businesses EO...USTRANSCOM U.S. Transportation Command VOSB veteran-owned small business WMD weapons of mass destruction WOSB women -owned small business xiv

  6. Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense

    DEFF Research Database (Denmark)

    Brodersen, Peter; Petersen, Morten; Pike, Helen M

    2002-01-01

    by avirulent pathogens. Global transcriptional changes during programmed cell death (PCD) and defense activation in acd11 were monitored by cDNA microarray hybridization. The PCD and defense pathways activated in acd11 are salicylic acid (SA) dependent, but do not require intact jasmonic acid or ethylene...

  7. Growth and chemical defense in relation to resource availability: tradeoffs or common responses to environmental stress?

    Directory of Open Access Journals (Sweden)

    J. S. Almeida-Cortez

    Full Text Available One aspect of plant defense is the production of constitutive secondary compounds that confer toxicity on herbivores and pathogens. The purpose of this study was to compare patterns of plant tissue toxicity across gradients of irradiance and nutrient content. We measured the potential toxicity (1/LC50 of extracts of six species of herbaceous Asteraceae grown under controlled conditions of temperature (25ºC, humidity (80%, photoperiod (16 h/day, in a range of concentrations of a modified Hoagland hydroponic solution (full-strength, 1/5 dilute, 1/10 dilute, and 1/50 dilute and under two different light intensities (250 and 125 mumol/m²/s. The plants grew from seed for 42 days post-germination, and randomly chosen plants were harvested each 7 days. We did a general measure of potential phytochemical toxicity using an alcohol extraction of secondary compounds followed by brine shrimp (Artemia sp. bioassay. Contrary to the carbon/nutrient balance hypothesis, tissue toxicity generally increased with decreasing irradiance and nutrient levels, so that plants whose growth was most restricted had tissues that were most toxic, although there were species-specific differences in this trend.

  8. Up-regulation of lipoxygenase, phospholipase, and oxylipin-production in the induced chemical defense of the red alga Gracilaria chilensis against epiphytes.

    Science.gov (United States)

    Weinberger, Florian; Lion, Ulrich; Delage, Ludovic; Kloareg, Bernard; Potin, Philippe; Beltrán, Jessica; Flores, Verónica; Faugeron, Sylvain; Correa, Juan; Pohnert, Georg

    2011-07-01

    The red alga Gracilaria chilensis is commercially farmed for the production of agar hydrocolloids, but some susceptible algae in farms suffer from intense epiphyte growth. We investigated the induced chemical defense response of G. chilensis against epiphytes and demonstrated that an extract of an epiphyte-challenged alga can trigger a defense response. The hormonally active metabolites were purified by RP-HPLC. Treatment with the extract or the purified fraction changed the chemical profile of the alga and increased resistance against epiphyte spores. Semi-quantitative RT-PCR and enzyme assays demonstrated that this metabolic response occurs after an increase in lipoxygenase and phospholipase A2 activity. Although this suggests the involvement of regulatory oxylipins, neither jasmonic acid nor the algal metabolite prostaglandin E2 triggers comparable defense responses.

  9. The Defense Threat Reduction Agency's Technical Nuclear Forensics Research and Development Program

    Science.gov (United States)

    Franks, J.

    2015-12-01

    The Defense Threat Reduction Agency (DTRA) Technical Nuclear Forensics (TNF) Research and Development (R&D) Program's overarching goal is to design, develop, demonstrate, and transition advanced technologies and methodologies that improve the interagency operational capability to provide forensics conclusions after the detonation of a nuclear device. This goal is attained through the execution of three focus areas covering the span of the TNF process to enable strategic decision-making (attribution): Nuclear Forensic Materials Exploitation - Development of targeted technologies, methodologies and tools enabling the timely collection, analysis and interpretation of detonation materials.Prompt Nuclear Effects Exploitation - Improve ground-based capabilities to collect prompt nuclear device outputs and effects data for rapid, complementary and corroborative information.Nuclear Forensics Device Characterization - Development of a validated and verified capability to reverse model a nuclear device with high confidence from observables (e.g., prompt diagnostics, sample analysis, etc.) seen after an attack. This presentation will outline DTRA's TNF R&D strategy and current investments, with efforts focusing on: (1) introducing new technical data collection capabilities (e.g., ground-based prompt diagnostics sensor systems; innovative debris collection and analysis); (2) developing new TNF process paradigms and concepts of operations to decrease timelines and uncertainties, and increase results confidence; (3) enhanced validation and verification (V&V) of capabilities through technology evaluations and demonstrations; and (4) updated weapon output predictions to account for the modern threat environment. A key challenge to expanding these efforts to a global capability is the need for increased post-detonation TNF international cooperation, collaboration and peer reviews.

  10. Patriot/Medium Extended Air Defense System Combined Aggregate Program (Patriot/MEADS CAP)

    Science.gov (United States)

    2013-12-01

    FUE - First Unit Equipped IOT &E - Initial Operational Test and Evaluation Missile Milestones SAR Baseline Dev Est Current APB Development...Acquisition Management Information Retrieval Dev Est - Development Estimate DoD - Department of Defense DSN - Defense Switched Network Econ...Milestone c FUE IOT &E Start Complete Full Rate Production Deci... AcQuisition Increment 2 Milestone C Lightweight Launcher FUE IOT &E Start

  11. Risk communications and the Chemical Stockpile Emergency-Planning Program

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, B.M.; Sorensen, J.H.

    1994-09-01

    The CSEPP (Chemical Stockpile Emergency Preparedness Program) was created to improve emergency planning and response capabilities at the eight sites around the country that store chemical weapons. These weapons are scheduled to be destroyed in the near future. In preparation of the Draft Programmatic Environmental Impact Statement (DPEIS) for the Chemical Stockpile Disposal Program (CSDP), it was proposed that the Army mitigate accidents through an enhanced community emergency preparedness program at the eight storage sites. In 1986, the Army initiated the development of an Emergency Response Concept Plan (ERCP) for the CSDP, one of 12 technical support studies conducted during preparation of the Final Programmatic Environmental Impact Statement (FPEIS). The purpose of this document is to provide a fairly comprehensive source book on risk, risk management, risk communication research and recommended risk communication practices. It does not merely summarize each publication in the risk communication literature, but attempts to synthesize them along the lines of a set of organizing principles. Furthermore, it is not intended to duplicate other guidance manuals (such as Covello et al.`s manual on risk comparison). The source book was developed for the CSEPP in support of the training module on risk communications. Although the examples provided are specific to CSEPP, its use goes beyond that of CSEPP as the findings apply to a broad spectrum of risk communication topics. While the emphasis is on communication in emergency preparedness and response specific to the CSEPP, the materials cover other non-emergency communication settings. 329 refs.

  12. Interactions between Bacteria And Aspen Defense Chemicals at the Phyllosphere - Herbivore Interface.

    Science.gov (United States)

    Mason, Charles J; Lowe-Power, Tiffany M; Rubert-Nason, Kennedy F; Lindroth, Richard L; Raffa, Kenneth F

    2016-03-01

    Plant- and insect-associated microorganisms encounter a diversity of allelochemicals, and require mechanisms for contending with these often deleterious and broadly-acting compounds. Trembling aspen, Populus tremuloides, contains two principal groups of defenses, phenolic glycosides (salicinoids) and condensed tannins, which differentially affect the folivorous gypsy moth, Lymantria dispar, and its gut symbionts. The bacteria genus Acinetobacter is frequently associated with both aspen foliage and gypsy moth consuming that tissue, and one isolate, Acinetobacter sp. R7-1, previously has been shown to metabolize phenolic glycosides. In this study, we aimed to characterize further interactions between this Acinetobacter isolate and aspen secondary metabolites. We assessed bacterial carbon utilization and growth in response to different concentrations of phenolic glycosides and condensed tannins. We also tested if enzyme inhibitors reduce bacterial growth and catabolism of phenolic glycosides. Acinetobacter sp. R7-1 utilized condensed tannins but not phenolic glycosides or glucose as carbon sources. Growth in nutrient-rich medium was increased by condensed tannins, but reduced by phenolic glycosides. Addition of the P450 enzyme inhibitor piperonyl butoxide increased the effects of phenolic glycosides on Acinetobacter sp. R7-1. In contrast, the esterase inhibitor S,S,S,-tributyl-phosphorotrithioate did not affect phenolic glycoside inhibition of bacterial growth. Degradation of phenolic glycosides by Acinetobacter sp. R7-1 appears to alleviate the cytotoxicity of these compounds, rather than provide an energy source. Our results further suggest this bacterium utilizes additional, complementary mechanisms to degrade antimicrobial phytochemicals. Collectively, these results provide insight into mechanisms by which microorganisms contend with their environment within the context of plant-herbivore interactions.

  13. Chemical and Biological Defense: Designated Entity Needed to Identify, Align, and Manage DOD’s Infrastructure

    Science.gov (United States)

    2015-06-01

    vesicles, or blisters , on exposed skin. Figure 6 shows USAMRICD’s new headquarters and laboratory facility. 3A Leadership in Energy and Environmental...To Report Fraud, Waste , and Abuse in Federal Programs Congressional Relations Public Affairs Please Print on Recycled Paper.

  14. Contributions of the Department of Defense Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs to Training and Education: FY1999-FY2004

    Science.gov (United States)

    2006-01-01

    allows visual tracking, free-floating Magnetic Levitation ( Maglev ) haptic feedback with real surgical tools and sce- nario-based training that can be...Defense Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs to Training and Education: FY1999–FY2004 J.D...Department of Defense Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs to Training and Education: FY1999

  15. Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae

    Directory of Open Access Journals (Sweden)

    Makarov Slobodan E.

    2012-01-01

    Full Text Available The troglomorphic millipede Brachydesmus troglobius Daday, 1889 (Polydesmida: Polydesmidae secretes allomones from glands on both lateral surfaces of its body segments. The secretion was identified by gas chromatography-mass spectrometry (GC-MS analysis with electron and chemical ionization, and was shown to be composed of a mixture of benzaldehyde, benzyl alcohol, benzoylnitrile, benzoic acid and mandelonitrile benzoate. Hydrogen cyanide was qualitatively identified by the picric acid test. This is the first identification of these compounds in a cave-dwelling polydesmid.

  16. Secondary Metabolome Variability and Inducible Chemical Defenses in the Mediterranean Sponge Aplysina cavernicola.

    Science.gov (United States)

    Reverter, M; Perez, T; Ereskovsky, A V; Banaigs, B

    2016-01-01

    Secondary metabolites play a crucial role in marine invertebrate chemical ecology. Thus, it is of great importance to understand factors regulating their production and sources of variability. This work aimed to study the variability of the bromotyrosine derivatives in the Mediterranean sponge Aplysina cavernicola, and also to better understand how biotic (reproductive state) and abiotic factors (seawater temperature) could partly explain this variability. Results showed that the A. cavernicola reproductive cycle has little effect on the variability of the sponges' secondary metabolism, whereas water temperature has a significant influence on the production level of secondary metabolites. Temporal variability analysis of the sponge methanolic extracts showed that bioactivity variability was related to the presence of the minor secondary metabolite dienone, which accounted for 50 % of the bioactivity observed. Further bioassays coupled to HPLC extract fractionation confirmed that dienone was the only compound from Aplysina alkaloids to display a strong bioactivity. Both dienone production and bioactivity showed a notable increase in October 2008, after a late-summer warming episode, indicating that A. cavernicola might be able to induce chemical changes to cope with environmental stressors.

  17. Secondary Defense Chemicals in Milkweed Reduce Parasite Infection in Monarch Butterflies, Danaus plexippus.

    Science.gov (United States)

    Gowler, Camden D; Leon, Kristoffer E; Hunter, Mark D; de Roode, Jacobus C

    2015-06-01

    In tri-trophic systems, herbivores may benefit from their host plants in fighting parasitic infections. Plants can provide parasite resistance in two contrasting ways: either directly, by interfering with the parasite, or indirectly, by increasing herbivore immunity or health. In monarch butterflies, the larval diet of milkweed strongly influences the fitness of a common protozoan parasite. Toxic secondary plant chemicals known as cardenolides correlate strongly with parasite resistance of the host, with greater cardenolide concentrations in the larval diet leading to lower parasite growth. However, milkweed cardenolides may covary with other indices of plant quality including nutrients, and a direct experimental link between cardenolides and parasite performance has not been established. To determine if the anti-parasitic activity of milkweeds is indeed due to secondary chemicals, as opposed to nutrition, we supplemented the diet of infected and uninfected monarch larvae with milkweed latex, which contains cardenolides but no nutrients. Across three experiments, increased dietary cardenolide concentrations reduced parasite growth in infected monarchs, which consequently had longer lifespans. However, uninfected monarchs showed no differences in lifespan across treatments, confirming that cardenolide-containing latex does not increase general health. Our results suggest that cardenolides are a driving force behind plant-derived resistance in this system.

  18. Palatability and chemical defense of Phragmites australis to the marsh periwinkle snail Littoraria irrorata.

    Science.gov (United States)

    Hendricks, Lindsey G; Mossop, Hannah E; Kicklighter, Cynthia E

    2011-08-01

    Coastal marsh habitats are impacted by many disturbances, including habitat destruction, pollution, and the introduction of invasive species. The common reed, Phragmites australis, has been particularly invasive in the mesohaline regions of the Chesapeake Bay, but few studies have investigated its role in trophic interactions with North American marsh consumers. The marsh periwinkle snail Littoraria irrorata is a common grazer in marshes and grazes on the native grass Spartina alterniflora. Whether this snail grazes on Phragmites has not been addressed. We found Spartina leaves to be tougher than those of Phragmites, but despite this, snails consumed significantly more Spartina than Phragmites. Subsequent experiments demonstrated that Phragmites is chemically deterrent to snails by an unknown, moderately polar, compound. Further studies are required to more fully understand the interactions between Phragmites, herbivores, and Spartina, and how they may impact marsh ecosystems.

  19. 75 FR 70248 - Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening

    Science.gov (United States)

    2010-11-17

    .... List of Subjects Environmental protection, Chemicals, Drinking water, Endocrine disruptors, Pesticides... AGENCY Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening AGENCY... chemicals and substances for which EPA intends to issue test orders under the Endocrine Disruptor...

  20. Program Management at the National Nuclear Security Administration Office of Defense Nuclear Security: A Review of Program Management Documents and Underlying Processes

    Energy Technology Data Exchange (ETDEWEB)

    Madden, Michael S.

    2010-05-01

    The scope of this paper is to review the National Nuclear Security Administration Office of Defense Nuclear Security (DNS) program management documents and to examine the underlying processes. The purpose is to identify recommendations for improvement and to influence the rewrite of the DNS Program Management Plan (PMP) and the documentation supporting it. As a part of this process, over 40 documents required by DNS or its stakeholders were reviewed. In addition, approximately 12 other documents produced outside of DNS and its stakeholders were reviewed in an effort to identify best practices. The complete list of documents reviewed is provided as an attachment to this paper.

  1. Maritime Defense and Security Research Program: Final Report, 2004-2011

    Science.gov (United States)

    2011-11-01

    Distributed Information Systems Experimentation ( DISE ) ........102 a. Maritime Domain Awareness: Spiral 1 Metrics ..................104 b. Maritime Domain...Trade Partnership against Terrorism DHS Department of Homeland Security DIA Defense Intelligence Agency DISE Distributed Information Systems...experimentations at DISE /NPS, to facilitate acquisition decision makers in merging, deleting, and acquiring new systems and technologies as the results

  2. Program Manager: Journal of the Defense Management College. Volume 16, Number 5, September-October 1987,

    Science.gov (United States)

    1987-10-01

    Defense Systems Knowledge of civilian and military engineering or Management .- , current DOD segments of DOD engineering College production/ improve... markt ur h’elin isthat pric gstrategy i -a fit a rc "-js Iten pt,turt he h firm can take m, le tnliuenCTd hv financial con ’tagc. Since executives

  3. 76 FR 38048 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

    Science.gov (United States)

    2011-06-29

    .... E-mail: dfars@osd.mil . Include DFARS Case 2011-D034 in the subject line of the message. Fax: 703... preceding the solicitation of sources by DoD for the procurement or transaction, any of the following for Do... least the one- year period preceding the solicitation of sources by the Department of Defense for...

  4. Defense Data Network/TOPS-20 Tutorial. An Interative Computer Program.

    Science.gov (United States)

    1985-12-01

    GRUP SB-GOUP Defense Data Network, DDN, TOPS-20, computer FIEL GRUP SB-GOUP networking. 19 ABSTRACT (Continue on roverse if necessary and identify by...switching network dedicated to meeting the data communica- tion requirements of the DoD. The network is subdivided into " two functional areas: (1) the

  5. Defense Transuranic Waste Program. Transuranic waste transportation assessment and guidance report

    Energy Technology Data Exchange (ETDEWEB)

    1985-08-01

    The Transportation Assessment and Guidance Report (TAGR) is designed to provide DOE-managed defense sites with guidance and citable analyses addressing National Environmental Policy Act (NEPA) requirements for qualifying and transporting transuranic (TRU) wastes to the Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico.

  6. Leaf surface lipophilic compounds as one of the factors of silver birch chemical defense against larvae of gypsy moth.

    Directory of Open Access Journals (Sweden)

    Vyacheslav V Martemyanov

    Full Text Available Plant chemical defense against herbivores is a complex process which involves a number of secondary compounds. It is known that the concentration of leaf surface lipophilic compounds (SLCs, particularly those of flavonoid aglycones are increased with the defoliation treatment of silver birch Betula pendula. In this study we investigated how the alteration of SLCs concentration in the food affects the fitness and innate immunity of the gypsy moth Lymantria dispar. We found that a low SLCs concentrations in consumed leaves led to a rapid larval development and increased females' pupae weight (= fecundity compared to larvae fed with leaves with high SLCs content. Inversely, increasing the compounds concentration in an artificial diet produced the reverse effects: decreases in both larval weight and larval survival. Low SLCs concentrations in tree leaves differently affected larval innate immunity parameters. For both sexes, total hemocytes count in the hemolymph increased, while the activity of plasma phenoloxidase decreased when larvae consume leaves with reduced content of SLCs. Our results clearly demonstrate that the concentration of SLCs in silver birch leaves affects not only gypsy moth fitness but also their innate immune status which might alter the potential resistance of insects against infections and/or parasitoids.

  7. Plant phenolics as chemical defenses: Effects of natural phenolics on survival and growth of prairie voles (Microtus ochrogaster).

    Science.gov (United States)

    Lindroth, R L; Batzli, G O

    1984-02-01

    Very few studies have shown experimentally that plant chemical defenses actually reduce the performance of individual mammalian herbivores, much less the density of mammalian populations. We investigated the effects of representatives of three classes of plant phenoiics on the survival and growth of prairie voles by incorporating the compounds into artificial diets and feeding them to weanlings for three weeks. At low levels of protein, both quercetin (a flavonoid) and tannic acid (a hydrolyzable tannin) caused reduced growth rates; no effect occurred at high levels of protein. Quebracho (a condensed tannin) inhibited feeding and thus was lethal at all levels of protein. These results indicate that plant phenolics are likely to influence the performance and dynamics of natural populations of microtine rodents by reducing the quality of available forage. The hypothesis that the primary mode of action of the phenoiics is the reduction of digestibility of protein was not supported. The reduced growth caused by both quercetin and tannic acid could be attributed primarily to their toxicity. The effect of quebracho resulted from reduced intake (unpalatability).

  8. Evolution of the Department of Defense Millimeter and Microwave Monolithic Integrated Circuit Program

    Science.gov (United States)

    2007-02-01

    Dertouzos, Michael; Lester, Richard K.; Solow , Robert M.; Thorow, Lester C., “Toward a New Industrial America Scientific American, June 1989, pp...Vladimir Gelnovatch, Director of the U.S. Army Electronics Technology and Devices Laboratory; and Robert Heaston, Office of Under Secretary of Defense...Jack S. Kilby and Robert N. Noyce shared honors for the achievement. Hybrid microwave and millimeter wave integrated circuits achieved greater

  9. FY 1978 Budget, FY 1979 Authorization Request and FY 1978-1982 Defense Programs,

    Science.gov (United States)

    1977-01-17

    timely inteligence to decision-makers for supporting national and Defense policies and decisions is increasing. 3 On the other hand, appropriation... artificially constrained by the lack of parts. This will increase materiel readiness and make the maintenance effort more efficient by reducing the backlog of...already too high, may in fact be artificially deflated. Chart VII-3 shows that cannibalization rates in the Navy and Air Force have been steadily

  10. 77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation...

    Science.gov (United States)

    2012-02-24

    ... Regulation Supplement; Extension of the Test Program for Negotiation of Comprehensive Small Business... Acquisition Regulation Supplement to extend the program period for the DoD Test Program for Negotiation of...). Section 866 amends the DoD Test Program for Negotiation of Comprehensive Small Business...

  11. Environmental management of assembled chemical weapons assessment program.

    Energy Technology Data Exchange (ETDEWEB)

    Frey, G.; Mohrman, G.; Templin, B. R.

    1999-05-07

    Environmental planning and management was an integral part of the ACWA Program planning process. To ensure that environmental protection issues could be addressed expeditiously and not delay the demonstrations, the PMACWA scaled the technology demonstrations such that simplified regulatory processes and existing research and development facilities could be used. The use of enclosed facilities for the demonstrations prevents any uncontrolled discharges to the environment and made it possible to conduct environmental assessments relatively quickly. The PMACWA also arranged for public briefings to ease any community concerns over the operations with chemical weapons. These steps precluded regulatory and community resistance to the ACWA activities. The cooperation of the regulators and stakeholders has been a key element in enabling the ACWA Program to move with the speed that it has to date. Technology demonstrations are currently underway and are scheduled to be completed in late May 1999. The data collected during these demonstrations will be used to prepare and submit a summary report to Congress by August 1999. The challenge continues for the ACWA management to guide the demonstrations to completion and to plan for possible pilot testing. As the scale of the ACWA facilities increase in size, the ease of reduced regulatory processes and environmental analyses will no longer be possible. However, the PMACWA will continue to explore all paths through the environmental process to speed the ACWA program to its goals while at the same time ensuring adequate protection of public health and safety and of the environment.

  12. [A participatory ergonomics program in a chemical company].

    Science.gov (United States)

    García, Ana M; Sevilla, María José; Gadea, Rafael; Casañ, Consuelo

    2012-01-01

    We describe a participatory ergonomics program that started in April 2010 in a chemical company located in the autonomous region of Valencia, Spain. The program was introduced in the company, the intervention level was agreed (two working lines, 24 workers) and a working group was established (Ergo Group, including managers, technicians and safety representatives in the company) with the aim of leading the intervention. A questionnaire was applied to collect information on ergonomic injuries and exposures in workers at the selected working lines. This information was analyzed by the Ergo Group and was later discussed at prevention circles with the direct participation of affected workers. When the present article was being drafted, 16 improvements to working conditions had already been proposed. Some of these improvements had been implemented and, in the opinion of some of the participants, were effective. To develop this kind of program, which could benefit a substantial number of workers in Spain, a firm commitment to prevention by companies is required.

  13. Understanding Complexity and Self-Organization in a Defense Program Management Organization (Experimental Design)

    Science.gov (United States)

    2016-03-18

    start of the program. Earned value management data will be used to determine program schedule variance. Program Performance Program performance will...and schedule of the program. Table 4 provides a definition of key earned value terms. Table 4. Earned Value Management Key Terms Subsequent...Sasieni, M. W. (1968). The engineering and management of an effective system. Management Science, 14(12), B-721–B-730. Fredrickson, J. W

  14. 76 FR 34720 - Chemical Facility Anti-Terrorism Standards Personnel Surety Program

    Science.gov (United States)

    2011-06-14

    ... SECURITY Chemical Facility Anti-Terrorism Standards Personnel Surety Program AGENCY: National Protection... . SUPPLEMENTARY INFORMATION Program Description The Chemical Facility Anti-Terrorism Standards (CFATS), 6 CFR Part... Section 550, the Chemical Facility Anti-Terrorism Standards, 6 CFR Part 27. Section 550 requires that...

  15. Feeding on Host Plants with Different Concentrations and Structures of Pyrrolizidine Alkaloids Impacts the Chemical-Defense Effectiveness of a Specialist Herbivore

    Science.gov (United States)

    Cunha, Beatriz P.; Solferini, Vera N.

    2015-01-01

    Sequestration of chemical defenses from host plants is a strategy widely used by herbivorous insects to avoid predation. Larvae of the arctiine moth Utetheisa ornatrix feeding on unripe seeds and leaves of many species of Crotalaria (Leguminosae) sequester N-oxides of pyrrolizidine alkaloids (PAs) from these host plants, and transfer them to adults through the pupal stage. PAs confer protection against predation on all life stages of U. ornatrix. As U. ornatrix also uses other Crotalaria species as host plants, we evaluated whether the PA chemical defense against predation is independent of host plant use. We fed larvae from hatching to pupation with either leaves or seeds of one of eight Crotalaria species (C. incana, C. juncea, C. micans, C. ochroleuca, C. pallida, C. paulina, C. spectabilis, and C. vitellina), and tested if adults were preyed upon or released by the orb-weaving spider Nephila clavipes. We found that the protection against the spider was more effective in adults whose larvae fed on seeds, which had a higher PA concentration than leaves. The exceptions were adults from larvae fed on C. paulina, C. spectabilis and C. vitellina leaves, which showed high PA concentrations. With respect to the PA profile, we describe for the first time insect-PAs in U. ornatrix. These PAs, biosynthesized from the necine base retronecine of plant origin, or monocrotaline- and senecionine-type PAs sequestered from host plants, were equally active in moth chemical defense, in a dose-dependent manner. These results are also partially explained by host plant phylogeny, since PAs of the host plants do have a phylogenetic signal (clades with high and low PA concentrations in leaves) which is reflected in the adult defense. PMID:26517873

  16. Feeding on Host Plants with Different Concentrations and Structures of Pyrrolizidine Alkaloids Impacts the Chemical-Defense Effectiveness of a Specialist Herbivore.

    Directory of Open Access Journals (Sweden)

    Carlos H Z Martins

    Full Text Available Sequestration of chemical defenses from host plants is a strategy widely used by herbivorous insects to avoid predation. Larvae of the arctiine moth Utetheisa ornatrix feeding on unripe seeds and leaves of many species of Crotalaria (Leguminosae sequester N-oxides of pyrrolizidine alkaloids (PAs from these host plants, and transfer them to adults through the pupal stage. PAs confer protection against predation on all life stages of U. ornatrix. As U. ornatrix also uses other Crotalaria species as host plants, we evaluated whether the PA chemical defense against predation is independent of host plant use. We fed larvae from hatching to pupation with either leaves or seeds of one of eight Crotalaria species (C. incana, C. juncea, C. micans, C. ochroleuca, C. pallida, C. paulina, C. spectabilis, and C. vitellina, and tested if adults were preyed upon or released by the orb-weaving spider Nephila clavipes. We found that the protection against the spider was more effective in adults whose larvae fed on seeds, which had a higher PA concentration than leaves. The exceptions were adults from larvae fed on C. paulina, C. spectabilis and C. vitellina leaves, which showed high PA concentrations. With respect to the PA profile, we describe for the first time insect-PAs in U. ornatrix. These PAs, biosynthesized from the necine base retronecine of plant origin, or monocrotaline- and senecionine-type PAs sequestered from host plants, were equally active in moth chemical defense, in a dose-dependent manner. These results are also partially explained by host plant phylogeny, since PAs of the host plants do have a phylogenetic signal (clades with high and low PA concentrations in leaves which is reflected in the adult defense.

  17. Feeding on Host Plants with Different Concentrations and Structures of Pyrrolizidine Alkaloids Impacts the Chemical-Defense Effectiveness of a Specialist Herbivore.

    Science.gov (United States)

    Martins, Carlos H Z; Cunha, Beatriz P; Solferini, Vera N; Trigo, José R

    2015-01-01

    Sequestration of chemical defenses from host plants is a strategy widely used by herbivorous insects to avoid predation. Larvae of the arctiine moth Utetheisa ornatrix feeding on unripe seeds and leaves of many species of Crotalaria (Leguminosae) sequester N-oxides of pyrrolizidine alkaloids (PAs) from these host plants, and transfer them to adults through the pupal stage. PAs confer protection against predation on all life stages of U. ornatrix. As U. ornatrix also uses other Crotalaria species as host plants, we evaluated whether the PA chemical defense against predation is independent of host plant use. We fed larvae from hatching to pupation with either leaves or seeds of one of eight Crotalaria species (C. incana, C. juncea, C. micans, C. ochroleuca, C. pallida, C. paulina, C. spectabilis, and C. vitellina), and tested if adults were preyed upon or released by the orb-weaving spider Nephila clavipes. We found that the protection against the spider was more effective in adults whose larvae fed on seeds, which had a higher PA concentration than leaves. The exceptions were adults from larvae fed on C. paulina, C. spectabilis and C. vitellina leaves, which showed high PA concentrations. With respect to the PA profile, we describe for the first time insect-PAs in U. ornatrix. These PAs, biosynthesized from the necine base retronecine of plant origin, or monocrotaline- and senecionine-type PAs sequestered from host plants, were equally active in moth chemical defense, in a dose-dependent manner. These results are also partially explained by host plant phylogeny, since PAs of the host plants do have a phylogenetic signal (clades with high and low PA concentrations in leaves) which is reflected in the adult defense.

  18. Superhydrophobic powder additives to enhance chemical agent resistant coating systems for military equipment for the U.S. Marine Corps (USMC) Corrosion Prevention and Control (CPAC) Program

    Energy Technology Data Exchange (ETDEWEB)

    Pawel, Steven J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Armstrong, Beth L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Haynes, James A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-07-01

    The primary goal of the CPAC program at ORNL was to explore the feasibility of introducing various silica-based superhydrophobic (SH) powder additives as a way to improve the corrosion resistance of US Department of Defense (DOD) military-grade chemical agent resistant coating (CARC) systems. ORNL had previously developed and patented several SH technologies of interest to the USMC, and one of the objectives of this program was to identify methods to incorporate these technologies into the USMC’s corrosion-resistance strategy. This report discusses findings of the CPAC and their application.

  19. The 26th AFOSR chemical and atmospheric sciences program review FY81

    Science.gov (United States)

    Thorpe, W. G.; Myers, L. E.; Stallings, S. A.

    1982-03-01

    A review is presented of research efforts sponsored by the Directorate of Chemical and Atmospheric Sciences which have completed their period of support. Illustrated accounts resulting from the basic research programs in the Atmospheric and Chemical Sciences are highlighted. The Atmospheric Sciences is concerned with meteorology and upper atmospheric structure and dynamics. The meteorology focuses on mesoscale meteorology, cloud physics, and atmospheric dynamics. The Chemical Sciences deal with Chemical Techniques, Chemical Structures, Surface Chemistry, Chemical Dynamics, and Synthesis and properties of Materials.

  20. Joint Service Chemical and Biological Defense Program: FY 06-07 Overview

    Science.gov (United States)

    2006-01-01

    the drug Cidofovir ® in NHP models supporting the FDA’s animal rule, and provide technical data regarding potential oral proforms of the drug...B). • Complete technical data package for FDA approval of a labeled indication of i.v. Cidofovir ® for pre- and post-exposure treatment of orthopox

  1. Multiple Animal Studies for Medical Chemical Defense Program in Soldier/ Patient Decontamination and Drug Development

    Science.gov (United States)

    1988-12-01

    for micronuclei determination. Particular emphasis is placed on evaluating any transient leucopenia , leucocytosis, and/or agranulocytosis as a function...for micronuclei determination. Particular emphasis is placed on evaluating any transient leucopenia , leucocytosis, and/orU agranulocytosis as a

  2. Major Defense Acquisition Program (MDAP) Trail Boss Overview and Joint Strike Fighter Decontamination Shelter System

    Science.gov (United States)

    2011-11-01

    Individual Protection Joint Project Manager  Individual Protection 3 JAN 11 Joint Project Manager  Chemical Biological Medical Systems ( Biosurveillance ...Trail Boss) Joint Project Manager  Chemical Biological Medical Systems ( Biosurveillance  Trail Boss) • ra oss      Decontamination  Joint Project

  3. Defense Small Business Innovation Research Program (SBIR). Volume 1. Army Abstracts of Phase 1 Awards 1992

    Science.gov (United States)

    1992-01-01

    battery could weigh less than 8 lb, with a size of less than I cubic foot. It is based on a demonstrated chemical and bioltgical agent puritying oxygen... zirconia ) in the presence of an electric potential. This pump promises to be the low noise powkei 22 ARMY SBIR PHASE I AWARDS supply to use with...chemical reactions. Dehydrated food powders and particles are also used in "liquid meals" for dental patients. However, dehydrated foods traditionally

  4. Structure-activity relationships of pyrrolizidine alkaloids in insect chemical defense against the orb-weaving spider Nephila clavipes.

    Science.gov (United States)

    Silva, Karina Lucas; Trigo, José Roberto

    2002-04-01

    Pyrrolizidine alkaloids (PAs) are known to protect Arctiidae moths and Danainae and Ithomiinae butterflies against the orb-weaving spider Nephila clavipes (Araneae, Araneidae, Tetragnathinae), which liberates adults of these insects unharmed from its web. We tested against this spider the role of eight PAs and one derived structure [an 89:11 mixture of the 12-membered macrocyclic diester free base integerrimine and senecionine and the respective N-oxide; two hydrolysis products from this mixture (the necine base retronecine, its respective N-oxide, and a mixture of integerriminic and senecionic necic acids); the 12-membered macrocyclic senkirkine; the 9-O-monoester free base senecioylretronecine and its respective N-oxide; and the 9-O-monoester free base callimorphine (a PA biosynthesized only by insects from retronecine)]. The mixture integerrimine-senecionine N-oxide seems to be more active than the respective free base [LibD50 (liberation dose 50) = 0.042 and 0.153 microg/dry weight of prey, respectively], but the difference in activity between the N-oxide and free base of the 9-O-monoester senecioylretronecine was slight (LibD50 = 0.167 and 0.104, respectively). Senkirkine, an otonecine base PA that does not form N-oxide and is not found in insects, was the less active, showing the highest LibD50 (0.354). The difference in antipredator activity between N-oxides and free bases from macrocyclic diesters and monoesters may be correlated with physicochemical properties of these molecules in interaction with the Nephila receptors. For the active structures, there was a significant correlation between dosage and antipredator activity. Both forms of retronecine and a necic acid mixture were inactive, supporting the hypothesis that PAs biosynthesized by insects from retronecine were originally produced and stored in order to optimize chemical defense. Comparison of dose/activity data with reported amounts of PAs in butterflies suggested that, in general, PA

  5. 75 FR 66686 - Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for...

    Science.gov (United States)

    2010-10-29

    ... Regulation Supplement; Balance of Payments Program Exemption for Commercial Information Technology... Acquisition Regulation Supplement (DFARS) to implement the exemption from the Balance of Payments Program for... is amending the DFARS to implement in the clauses at 252.225- 7044, Balance of Payments...

  6. The efficacy of chemical agents in cleaning and disinfection programs

    Directory of Open Access Journals (Sweden)

    Silva Martins Alzira

    2001-09-01

    Full Text Available Abstract Background Due to the growing number of outbreaks of infection in hospital nurseries, it becomes essential to set up a sanitation program that indicates that the appropriate chemical agent was chosen for application in the most effective way. Method For the purpose of evaluating the efficacy of a chemical agent, the minimum inhibitory concentration (MIC was reached by the classic method of successive broth dilutions. The reference bacteria utilized were Bacillus subtilis var. globigii ATCC 9372, Bacillus stearothermophilus ATCC 7953, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923. The strains of Enterobacter cloacae IAL 1976 (Adolfo Lutz Institute, Serratia marcescens IAL 1478 and Acinetobactev calcoaceticus IAL 124 (ATCC 19606, were isolated from material collected from babies involved in outbreaks of infection in hospital nurseries. Results The MIC intervals, which reduced bacteria populations over 08 log10, were: 59 to 156 mg/L of quaternarium ammonium compounds (QACs; 63 to 10000 mg/L of chlorhexidine digluconate; 1375 to 3250 mg/L of glutaraldehyde; 39 to 246 mg/L of formaldehyde; 43750 to 87500 mg/L of isopropanol or ethanol; 1250 to 6250 mg/L of iodine in polyvinyl-pyrolidone complexes, 150 to 4491 mg/L of chlorine-releasing-agents (CRAs; 469 to 2500 mg/L of hydrogen peroxide; and, 2310 to 18500 mg/L of peracetic acid. Conclusions Chlorhexidine showed non inhibitory activity over germinating spores. A. calcoaceticus, was observed to show resistance to the majority of the agents tested, followed by E. cloacae and S. marcescens.

  7. Rapidly induced chemical defenses in maize stems and their effects on short-term growth of Ostrinia nubilalis.

    Science.gov (United States)

    Dafoe, Nicole J; Huffaker, Alisa; Vaughan, Martha M; Duehl, Adrian J; Teal, Peter E; Schmelz, Eric A

    2011-09-01

    Plants damaged by insect herbivory often respond by inducing a suite of defenses that can negatively affect an insect's growth and fecundity. Ostrinia nubilalis (European corn borer, ECB) is one of the most devastating insect pests of maize, and in the current study, we examined the early biochemical changes that occur in maize stems in response to ECB herbivory and how these rapidly induced defenses influence the growth of ECB. We measured the quantities of known maize defense compounds, benzoxazinoids and the kauralexin class of diterpenoid phytoalexins. ECB herbivory resulted in decreased levels of the benzoxazinoid, 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one)-β-D-glucopyranose (DIMBOA-Glc), and a corresponding increase in 2-(2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one)-β-D-glucopyranose (HDMBOA-Glc). Total quantities of benzoxazinoids and kauralexins were increased as early as 24 h after the initiation of ECB feeding. The plant hormones, jasmonic acid (JA) and ethylene (ET), and the transcripts encoding their key biosynthetic enzymes also accumulated in response to ECB herbivory, consistent with a role in defense regulation. The combined pharmacological application of JA and the ET precursor, 1-aminocyclopropane-1-carboxylic acid to stem internode tissue likewise resulted in changes in benzoxazinoids similar to that observed with ECB damage. Despite the fact that maize actively mounts a defense response to ECB stem feeding, no differences in percent weight gain were observed between ECB larvae that fed upon non-wounded control tissues compared to tissues obtained from plants previously subjected to 24 h ECB stem herbivory. These rapid defense responses in maize stems do not appear to negatively impact ECB growth, thus suggesting that ECB have adapted to these induced biochemical changes.

  8. Major Automated Information Systems: Selected Defense Programs Need to Implement Key Acquisition Practices

    Science.gov (United States)

    2014-03-01

    information system NGEN Next Generation Enterprise Network PMBOK ® Project Management Body of Knowledge TMIP-J Theater Medical Information Program...Management Institute’s Guide to the Project Management Body of Knowledge ( PMBOK ®), and assessed each of the 3 programs against these criteria.14 To...1) requirements management and (2) project monitoring and control best practices, as defined by CMMI-ACQ and PMBOK ®. We also assessed these

  9. Addressing the Barriers to Agile Development in the Department of Defense: Program Structure, Requirements, and Contracting

    Science.gov (United States)

    2015-04-30

    barriers within the DoD acquisition system (Broadus, 2013). MITRE performed initial research to examine the leading Agile methodologies and commercial...that suit each organization’s IT environment. Various Agile methods (e.g., Scrum , Extreme Programming (XP), Kanban, Test Driven Development) have... methodology . Traditional waterfall programs usually have discrete acquisition phases driven by milestone events to deliver a large capability. Agile is more

  10. Defense Small Business Innovation Research Program (SBIR). Volume 2. Navy Abstracts of Phase 1 Awards. 1990

    Science.gov (United States)

    1990-01-01

    TRAINING. DELFIN SYSTEMS 1349 MOFFETT PARK DR 78 SMALL BUSINESS INNOVATION RESEARCH PROGRAM - PHASE I NAVY Solicitation 90.1 SUNNYVALE, CA 94089 Program...MACHINE-INTERFACES (MMI). IMPLEMENTED MMI DESIGN SHOULD REFLECT HOW THE OPERATOR ACTUALLY USES AND INTERACTS WITH THE MACHINE. DELFIN WILL ANALYZE AND...DESIGN A GENERIC EXPERT SYSTEM MMI USEFUL IN ANY DEPLOYED ESM SYSTEM. DELFIN WILL GENERICALLY DEFINE CRYPTOLOGIC SYSTEMM USE AND TECHNICAL

  11. Department of Defense (DOD) renewables and energy efficiency planning (REEP) program manual

    Energy Technology Data Exchange (ETDEWEB)

    Nemeth, R.J.; Fournier, D.; Debaillie, L.; Edgar, L.; Stroot, P.; Beasley, R.; Edgar, D.; McMillen, L.; Marren, M.

    1995-08-01

    The Renewables and Energy Efficiency Planning (REEP) program was developed at the US Army Construction Engineering Research Laboratories (USACERL). This program allows for the analysis of 78 energy and water conservation opportunities at 239 major DOD installations. REEP uses a series of algorithms in conjunction with installation specific data to estimate the energy and water conservation potential for entire installations. The program provides the energy, financial, pollution, and social benefits of conservation initiatives. The open architecture of the program allows for simple modification of energy and water conservation variables, and installation database values to allow for individualized analysis. The program is essentially a high-level screening tool that can be used to help identify and focus preliminary conservation studies. The REEP program requires an IBM PC or compatible with a 80386 or 80486 microprocessor. It also requires approximately 4 megabytes of disk space and at least 8 megabytes of RAM. The system was developed for a Windows environment and requires Microsoft Windows 3.1{trademark} or higher to run properly.

  12. Guidelines for Chemistry and Chemical Technology Programs in Two-Year Colleges.

    Science.gov (United States)

    American Chemical Society, Washington, DC.

    Designed for use in institutional self-studies and program reviews, these guidelines provide a comprehensive model for chemistry and chemical technology programs in two-year, associate-degree-granting colleges. The eight sections of the guide suggest 90 standards in the areas of: (1) chemistry program mission and periodic program review; (2)…

  13. Conserved and species-specific oxylipin pathways in the wound-activated chemical defense of the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla

    Science.gov (United States)

    Rempt, Martin; Weinberger, Florian; Grosser, Katharina

    2012-01-01

    Summary Chemical defense of the invasive red alga Gracilaria vermiculophylla has been studied and compared to that of the noninvasive but related Gracilaria chilensis. Both species rely on a wound-activated chemical defense that makes them less attractive to the herbivorous sea snail Echinolittorina peruviana. The chemical stress response of both species was monitored by LC–ESIMS-based metabolic profiling and revealed commonalities and differences. Both algae rely on a rapid lipoxygenase mediated transformation of arachidonic acid to known and novel oxylipins. Common products are 7,8-dihydroxyeicosatetraenoic acid and a novel eicosanoid with an unusual γ-lactone moiety. Several prostaglandins were predominantly formed by the invasive species. The role of some of these metabolites was investigated by surveying the attachment of E. peruviana on artificial food containing the respective oxylipins. Both algae species are defended against this general herbivore by 7,8-dihydroxyeicosatetraenoic acid, whereas the prostaglandins and the novel oxylipins were inactive at naturally occurring concentrations. The role of different oxylipins in the invasive potential of Gracilaria spp. is discussed. PMID:22423296

  14. Conserved and species-specific oxylipin pathways in the wound-activated chemical defense of the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla

    Directory of Open Access Journals (Sweden)

    Martin Rempt

    2012-02-01

    Full Text Available Chemical defense of the invasive red alga Gracilaria vermiculophylla has been studied and compared to that of the noninvasive but related Gracilaria chilensis. Both species rely on a wound-activated chemical defense that makes them less attractive to the herbivorous sea snail Echinolittorina peruviana. The chemical stress response of both species was monitored by LC–ESIMS-based metabolic profiling and revealed commonalities and differences. Both algae rely on a rapid lipoxygenase mediated transformation of arachidonic acid to known and novel oxylipins. Common products are 7,8-dihydroxyeicosatetraenoic acid and a novel eicosanoid with an unusual γ-lactone moiety. Several prostaglandins were predominantly formed by the invasive species. The role of some of these metabolites was investigated by surveying the attachment of E. peruviana on artificial food containing the respective oxylipins. Both algae species are defended against this general herbivore by 7,8-dihydroxyeicosatetraenoic acid, whereas the prostaglandins and the novel oxylipins were inactive at naturally occurring concentrations. The role of different oxylipins in the invasive potential of Gracilaria spp. is discussed.

  15. Defensive chemicals of tawny crazy ants, Nylanderia fulva (Hymenoptera: Formicidae) and their toxicity to red imported fire ants, Solenopsis invicta (Hymenoptera: Formicidae).

    Science.gov (United States)

    Chen, Jian; Rashid, Tahir; Feng, Guolei; Zhao, Liming; Oi, David; Drees, Bastiaan Bart M

    2013-12-15

    Nylanderia fulva (Mayr) has been reported as being able to displace Solenopsis invicta Buren, one of the most aggressive invasive ants in the world. Like S. invicta, N. fulva use chemical secretions in their defense/offense, which may contribute to their observed superior competition ability. In this study, the defensive chemicals of N. fulva workers and their toxicity against S. invicta workers were investigated. Like other formicine ants, N. fulva workers produce formic acid in their poison glands and 2-ketones and alkanes in Dufour glands. Of these, undecane and 2-tridecanone are two principal compounds in the Dufour gland. Topical LD50 values of 2-tridecanone and undecane against S. invicta workers ranged from 18.51 to 24.67 μg/ant and 40.39 to 84.82 μg/ant, respectively. Undecane and 2-tridecanone had significantly higher contact toxicity than formic acid, whereas formic acid had significantly higher fumigation toxicity than undecane and 2-tridecanone. The combination of 2-tridecanone as a contact toxin and formic acid as a fumigant significantly decreased KT50 values when compared to those of individual compounds. N. fulva does not seem unique in terms of the chemistry of its defensive secretion as compared to other formicine ants. However, this ant contained more than two orders of magnitude of formic acid (wt/wt) than other formicine ants and one order of magnitude of 2-tridecanone than the common crazy ant, Paratrechina longicornis (Latreille). The quantity, rather than quality, of the chemical secretion may contribute to the superior competition ability of N. fulva.

  16. Effects of Exogenous Jasmonic Acid on Concentrations of Direct-Defense Chemicals and Expression of Related Genes in Bt(Bacillus thuringiensis)Corn(Zea mays)

    Institute of Scientific and Technical Information of China (English)

    FENG Yuan-jiao; WANG Jian-wu; LUO Shi-ming

    2007-01-01

    Bt corn is one of the top three large-scale commercialized transgenic crops around the world.It is increasingly clear that the complementary durable approaches for pest control,which combine the endogenous defense of the crop with the introduced foreign genes,are promising alternative strategies for pest resistance management and the next generation of insect-resistant transgenic crops.In the present study,we tested the inducible effects of exogenous jasmonic acid(JA) on direct-defense chemical content,Bt protein concentration,and related gene expression in the leaves of Bt corn cultivar 34B24 and non-Bt cultivar 34B23 by chemical analysis,ELISA,and RT-PCR.The results show that the expression of LOX,PR-2αMPI,and PR-1 genes in the treated leaf(the first leaf)was promoted by exogenous JA both in 34B24 and 34B23.As compared with the control,the concentration of DIMBOA in the treated leaf was significantly increased by 63 and 18% for 34B24 and 34B23,respectively.The total phenolic acid was also increased by 24 and 12% for both 34B24 and 34B23.The Bt protein content of 34B24 in the treated leaf was increased by 13% but decreased significantly by 27% in the second leaf.The induced response of 34B24 was in a systemic way and was much stronger than that of 34B23.Those findings indicated that there is a synergistic interaction between Bt gene and internally induced chemical defense system triggered by externally applied JA in Bt corn.

  17. Defense Small Business Innovation Research Program (SBIR). Volume 1. Army Abstracts of Phase 1 Awards 1993

    Science.gov (United States)

    1993-01-01

    pressure, without any pulsations or flow noise. A pump operating off a vehicular battery could weigh less than 8 lb. with a size of less than I cubic ...pressure of oxygen is developed due to ion flow across a solid electrolyte (yttrium-doped zirconia ) in the presence of an electric potential. This pump...chemical reactions. Dehydrated food powders and particles are also used in "liquid meals" for dental patients. However, dehydrated foods traditionally

  18. Department of Defense Federal Hazard Communication Training Program, Trainer’s Guide

    Science.gov (United States)

    1988-04-01

    strong alka PnwPrful nv4i7aera lKawod"u Ogcormoosmon or By"oucts Sulfur Oxides, Toxic Fluorine Compounds, Carbon Monoxide, Ammonium bisulfate Mardous...East Depot Signal Shop Sulfuric Acid Best Chemical Corp. Signal Shop Tight-Bond Cement Jones Industrial Corp. Car Repair Shop Tight-Seal Jones...Information Tell trainees: Marilyn works as a supervisor in a plant that uses ammonium nitrate to make gun powder and blasting agents. List choices and ask

  19. Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agency Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

    Science.gov (United States)

    1990-04-01

    LABORATORY UNDER THE CODE NAME " DELPHI ", FOR THE OFFICE OF STRATEGIC DEFENSE; AND BETATRON RESEARCH CONDUCTED BY BOTH U.S. AND SOVIET SOURCES SUPPORTS THE...TITLE: HYPERGOLIC FUEL INJECTOR FEATURES INCREASED UTILITY FOR REMOTELY PILOTED VEHICLES (RPVs) INCREASED RANGE ENDURANCE PAYLOAD MULTI.. TOPIC# 20...OFFICE: PM/SBIR IDENT#: 33860 A HYPERGOLIC FUEL INJECTOR IS DESCRIBED THAT ENABLES MULTIFUEL OPERATION, LOWER FUEL CONSUMPTION, AND ENHANCED ALL WEATHER

  20. Commercializing Defense Technologies and Helping Defense Firms Succeed in Commercial Markets: A Report on the Objectives, Activities, and Accomplishments of the TAP-IN Program

    Science.gov (United States)

    1997-01-01

    Technology Access for Product Innovation (TAP-IN), the largest technology deployment project funded by TRP, was competitively selected through a national solicitation for proposals. TAP-IN was created to help companies access and apply defense technologies and help defense-dependent companies enter new commercial markets. Defense technologies included technologies developed by DoD, DOE, NASA, and their contractors. TAP-IN was structured to provide region-based technology access services that were able to draw on technology resources nationwide. TAP-IN provided expert assistance in all stages of the commercialization process from concept through prototype design to capital sourcing and marketing strategy. TAP-IN helped companies locate new technology, identify business partners, secure financing, develop ideas for new products, identify new markets, license technology, solve technical problems, and develop company-specific applications of federal technology. TAP-IN leveraged NASA's existing commercial technology network to create an integrated national network of organizations that assisted companies in every state. In addition to NASA's six regional technology transfer centers (RTTCs), TAP-IN included business and technology development organizations in every state, the Industrial Designers Society of America, and the Federal Laboratory Consortium (FLC).

  1. Defense Small Business Innovation Research Program (SBIR). Volume 3. Air Force Abstracts of Phase 1 Awards

    Science.gov (United States)

    1990-01-01

    ROBOTS. KINOPHASE 14 HOLLY HILL DR AMHERST, NH 03031 Program Manager: GENE C KOCH Contract #: Title: LIQUID CRYSTAL SWITCHABLE KINOFORM LENSES FOR...NETWORKS WILL BE USED TO DEVELOP A REAL- CIME , MULTIMODALITY, NONINTRUSIVE PHYSIOLOGICAL METRIC OF MENTAL WORKLOAD. OUR METRIC WILL MEASURE MENTAL

  2. RDT&E Programs (R-1). Department of Defense Budget Fiscal Year 2010

    Science.gov (United States)

    2009-05-01

    52,716 U ( SIAP ) System Engineer (SE) 73 0603889N Counterdrug RDT&E Projects 04...20,582 U 91 0605452F Joint SIAP Executive Program 05 34,877...4,723 66,663 13,466 13,466 U ( SIAP ) 95 0207701F Full Combat Mission

  3. Defense Small Business Innovation Research Program (SBIR) Abstracts of Phase I Awards 1984.

    Science.gov (United States)

    1985-04-16

    DISPLACING AGENT CAN BE RECOVERED AND REUSED BY MEANS OF A COLD TRAP. INDUSTRIAL QUALITY, INC. NAVY $ 49,9900 9832 CANAL ROAD, P. 0. BOX 2397 GAITHERSBURG, MD...APPROACH IS BASED UPON PROVEN TECHNOLOGY FOR TREATMENT OF HUMAN WASTE, DOMESTIC GREYWATER SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM - PHASE I

  4. The Myth of Jointness in Department of Defense Requirements and Major Acquisition Programs

    Science.gov (United States)

    2013-06-01

    and Program Management for the F-4 Phantom II," Social Studies of Science 23, no. 2 (May 1993): 287. 5 Deborah Shapley, Promise and Power: The...for the F-4 Phantom II.” Social Studies of Science 23, No. 2 (May, 1993): 265-300. Bull, Stephen. "Encyclopedia of Military Technology and

  5. Defense Small Business Innovation Research Program (SBIR) Volume 2. Navy Abstracts of Phase 1 Awards, 1987

    Science.gov (United States)

    1988-04-01

    DYNAMICS, INCLUDING AUTOPILOT , AND AN ADEQUATE SIMULATED TERRAIN IMAGE FOR VEHICLES WITH ON-BOARD SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM...ELECTRONICS DOES NOT EXCEED A FRACTION OF A VOLT, NOT LIKELY IF THE RATE OF CHANGE OF AXIAL FLUX DENSITY IS LESS THAN 2.5 TESLA /SEC. A UNIQUE

  6. The Defense and Veterans Brain Injury Center Care Coordination Program: Assessment of Program Structure, Activities, and Implementation

    Science.gov (United States)

    2013-01-01

    RCCs who provided invaluable input about the program. We also thank our colleagues Deborah Scharf, Rajeev Ramchand, Lisa Mer- edith, Mike Fisher , and...Vandana Sundaram, Dena M. Bravata, Robyn Lewis, Nancy Lin, Sally A. Kraft, Moira McKinnon, Helen Paguntalan, and Douglas K. Owens, Closing the Quality

  7. 75 FR 77869 - Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening; Extension...

    Science.gov (United States)

    2010-12-14

    ... water, Endocrine disruptors, Pesticides and pests. Dated: December 8, 2010. Stephen A. Owens, Assistant... AGENCY Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening; Extension of... Endocrine Disruptor Screening Program's (EDSP) second list of chemicals for Tier 1 screening. This...

  8. 75 FR 18850 - National Protection and Programs Directorate; Chemical Facility Anti-Terrorism Standards...

    Science.gov (United States)

    2010-04-13

    ... SECURITY National Protection and Programs Directorate; Chemical Facility Anti-Terrorism Standards Personnel... commercial or financial information, Chemical-terrorism Vulnerability Information (CVI), Sensitive Security... Facility Anti-Terrorism Standards (CFATS), 6 CFR part 27, require high-risk chemical facilities to...

  9. Waste minimization policies, regulations, and practices within the U.S. Department of Energy defense programs

    Energy Technology Data Exchange (ETDEWEB)

    Mathur, S.P.

    1989-11-01

    In 1984 the US Congress enacted the Hazardous and Solid Waste Amendments (HSWA) to the Resource Conservation and Recovery Act (RCRA). One of the goals of this legislation was to focus attention on the need to reduce or eliminate hazardous waste so as to minimize the threat to human health and the environment. Subsequently, in September of 1988, DOE issued a Radioactive Waste Management Policy, DOE Order 5820.2A, and in November a General Environmental Program Order, DOE Order 5400.1. These documents embrace the principles set forth in RCRA, and expand their scope to include radioactive, mixed, and pollutant waste, and all actions for reducing waste from the point of generation through waste treatment, storage, transportation and disposal. This paper will present an overview of the legislation and policies for waste reduction and, in addition, give site responsibilities for implementing waste reduction program activities.

  10. Defense Acquisitions. Measuring the Value of DOD’s Weapon Programs Requires Starting with Realistic Baselines

    Science.gov (United States)

    2009-04-01

    schedule delay in delivering initial capabilities 18 months 21 months 22 months Source: GAO analysis of DOD data. aData were obtained from DOD’s...efficient. Too many major acquisitions currently take the opposite approach by seeking to deliver a revolutionary “ big bang” capability in one step...candidate programs and to go for the “ big bang” capability without the knowledge to achieve it should be resisted. Only the best candidates--defined in

  11. Defense Small Business Innovation Research Program (SBIR). Abstracts of Phase I Awards. 1986.

    Science.gov (United States)

    1986-01-01

    EMPHASIS OF ANY PHASE II WORK. ANAMET LABS INC AF $ 49,031 100 INDUSTRIAL WY SAN CARLOS, CA 94070 DANTON GUTIERREZ-LFMINI TITLE: COUPLED THERMOELASTIC...NATIONAL DR - STE 280 BURTONSVILLE, MD 20866 GEORGE MAHLER TITLE: THLL BASED SYMBOLIC DEBUG FACILITY FOR VAX/VMS T 104 OFFICE: NSWC THLL IS THE TRIDENT...VALLEY RD., SUITE 112 SAN DIEGO, CA 92121 GEORGE W WEBB , TITLE: MINIATURE CONDUCTORS FOR SENSORS T 3 OFFICE: WE DESCRIBE A FOUR PART RESEARCH PROGRAM

  12. Sources of Weapon System Cost Growth. Analysis of 35 Major Defense Acquisition Programs

    Science.gov (United States)

    2008-01-01

    Resource Management Program of RAND Proj- iii ect AIR FORCE. The project’s technical monitor is Jay Jordan, Techni- cal Director of the Air Force Cost...and for his long-term support of Project AIR FORCE’s acquisi- tion and cost analysis research. Richard Hartley (SAF/FMC) and Jay Jordan from the Air...Wickman (1993), Tyson, Nelson, and Utech (1992), Shaw (1982), Tyson et al. (1989), Asher and Maggelet (1984), and Drezner et al. (1993) studied cost

  13. A Macro-Stochastic Approach to Improved Cost Estimation for Defense Acquisition Programs

    Science.gov (United States)

    2014-03-27

    the United States Government. This material is declared a work of the U.S. Government and is not subject to copyright protection in the United...Aircraft, Helicopter, Missile , Electronic, Munitions, Vehicle, Ship, Space, and Other. Other summary-level variables include service component...older DDG-51 ships (Cancian, 2010)—both of these programs are in the dataset. Also, the Army’s “Longbow” 84 helicopter, and the “Longbow Hellfire

  14. Defense Small Business Innovation Research Program (SBIR). Volume 1. Army Abstracts of Phase 1 Awards 1987.

    Science.gov (United States)

    1988-04-01

    DIMENSIONAL FLOW SOLUTIONS. HORINE ENGINEERS INC PO BOX 2027 LOS GATOS , CA 95031 CONTRACT NUMBER: DAAA21-87-C-0190 CARLTON L HORINE TITLE: p IMPROVED GASKET...AN UNPARALLELED OPPORTUNITY TO SCREEN BACTERIA , FUNGI AND ALGAE FROM THERMALLY STABLE OXIDASES AND PEROXIDASES. ONCE ISOLATED, AN ATTEMPT WILL BE MADE...PROGRAM - PHASE 1 PAGE 106 BY SERVICE FISCAL YEAR 1987 ARMY SUBMITTED BY • TO DEVELOP AND TEST A SYSTEM. LASER-GENICS CORP PO BOX 33010 LOS GATOS , CA

  15. Development of an Intellectual Property Strategy: Research Notes to Support Department of Defense Programs

    Science.gov (United States)

    2014-10-01

    such as poetry , novels, movies, songs, computer software, drawings, and architecture. A copyright owner has the exclusive right to reproduce...market research—can support how requirements may be logically broken out into segments to maximize competition  records that substantiate sources...entitlement will maximize a program’s ability to utilize competitive alternatives for DoD development, modification, or upgrade effort. One suggestion is to

  16. Department of Defense High Performance Computing Modernization Program. 2006 Annual Report

    Science.gov (United States)

    2007-03-01

    Ground, MD Tip-to-Tail Turbulent Scramjet Flowpath Simulation with MHD Energy Bypass Datta Gaitonde, Air Force Research Laboratory, Wright- Patterson...Stennis Space Center in Mississippi, through a Phase II CAP titled “Quantum and Entropic Algorithms for MHD and Turbulent Flows.” They tested new...14 Force Field Lectures 50 HPC FPGA Programming 10 Insight Segmentation and Registration Toolkit Workshop (ITK) 18 Intermediate-Advanced EnSight 10

  17. Acquisition Program Teamwork and Performance Seen Anew: Exposing the Interplay of Architecture and Behaviors in Complex Defense Programs

    Science.gov (United States)

    2016-04-30

    Initiative’s Enterprise Product Development research. Dr. Rebentisch’s portfolio of research projects includes studies of the integration of program...of the application of the framework to identify management control “levers” for design, engineering, test and evaluation , fielding, and sustainment...than $1 billion for research, development, testing and evaluation in fiscal year 2005 dollars) initiated in the 1970s exceeded the DoD’s initial

  18. Program Helps To Determine Chemical-Reaction Mechanisms

    Science.gov (United States)

    Bittker, D. A.; Radhakrishnan, K.

    1995-01-01

    General Chemical Kinetics and Sensitivity Analysis (LSENS) computer code developed for use in solving complex, homogeneous, gas-phase, chemical-kinetics problems. Provides for efficient and accurate chemical-kinetics computations and provides for sensitivity analysis for variety of problems, including problems involving honisothermal conditions. Incorporates mathematical models for static system, steady one-dimensional inviscid flow, reaction behind incident shock wave (with boundary-layer correction), and perfectly stirred reactor. Computations of equilibrium properties performed for following assigned states: enthalpy and pressure, temperature and pressure, internal energy and volume, and temperature and volume. Written in FORTRAN 77 with exception of NAMELIST extensions used for input.

  19. American Chemical Society: Twentieth northeast regional meeting. Program and Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The proceedings contain papers on the following topics: preparation, characterization, and applications of fine particles; multinuclear NMR spectroscopy; chemical aspects of wine making; organic electrochemistry; chemical education; laboratory information management systems; laser-based processing and diagnostics of materials; modern liquid chromatography; high-temperature superconductivity; organic chemistry; chemometrics; colloid and surface science; biological chemistry; environmental sciences; drug analysis; and organometallic chemistry. Papers within the scope of the Energy Data Base have been processed separately.

  20. Countermeasures to Hazardous Chemicals,

    Science.gov (United States)

    1989-04-01

    of any effective community awareness and emergency response program is an informed public familiar with the operations of local chemical plants. Such a...protection systems. 2. Booklel, ’Protecting People and the Environment.’ - A concise booklet developed to familiarize the public with chemical operations and...Jefe, Seccion de Estudios y Planificacion 102. Civil Defense Administation c/Evaristo San Miguel, 8 Ministry of Interior Madrid-8 Ankara ESPANA

  1. A multicultural approach to HIV prevention within a residential chemical dependency treatment program: the Positive Steps Program.

    Science.gov (United States)

    Harris, Elizabeth; Kiekel, Preston; Brown, Kim; Sarmiento, Ana; Byock, Gayle

    2010-01-01

    Positive Steps is a six month residential program in southeastern Los Angeles County. The program seeks to assist residents in recovery from chemical dependency and to prevent sexual and other risk factors which promote HIV transmission. Positive Steps serves a multicultural population of women and transgender male to female. Program participants are allowed to bring up to two children with them in residence. Motivational interviewing serves as the foundation for chemical dependency treatment and HIV transmission risk reduction. Positive Steps also provides intensive group education. Individual counseling with a licensed mental health professional is provided for HIV Positive residents. External evaluation of the program involves a comprehensive assessment at baseline, six months post-baseline, and follow up. Program outcomes include statistically significant reductions in substance use, sexual risk behaviors, and symptoms of mental distress.

  2. Air Force Major Defense Acquisition Program Cost Growth Is Driven by Three Space Programs and the F-35A: Fiscal Year 2013 President’s Budget Selected Acquisition Reports

    Science.gov (United States)

    2014-01-01

    production FSD full-scale development FY fiscal year FYDP Future Years Defense Program GBS Global Broadcast System GLCM Ground Launched Cruise...Surveillance Target Attack Radar System (JSTARS) aircraft • Air-Launched Cruise Missile (ALCM) • Ground-Launched Cruise Missile ( GLCM ) • AGM-65A/B

  3. Review of the President’s Fiscal Year 2009 Budget Request for the Defense Health Program’s Private Sector Care Budget Activity Group

    Science.gov (United States)

    2008-05-28

    2009 budget request for the Defense Health Program’s Private Sector Care BAG. To do this, we reviewed (1) DOD’s justification for the request for the... Private Sector Care BAG, including the underlying estimates and the extent to which DOD considered historical information; and (2) changes between this...develop the budget requests for the Private Sector Care BAG in fiscal years 2008 and 2009. We also interviewed officials and analyzed documents from

  4. Information resources for assessing health effects from chemical exposure: Office of pesticides programs

    Energy Technology Data Exchange (ETDEWEB)

    Fenner-Crisp, P. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    The US Environmental Protection Agency (EPA) Office of Pesticide Programs is trying to develop a complete picture of a chemical`s toxicity and exposure profile. It is also important to share information in the office`s files because of pesticides, particularly as a consequence of agricultural use, find their way into places not necessarily intended.

  5. Abstracts of the 48. Canadian chemical engineering conference : technical program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    The conference was organized into six concurrent sessions devoted to fluidized bed technology, multi-phase reactors, catalysis, environmental technology, new developments, and biotechnology. A total of 491 papers were presented. Papers of particular interest to energy technology emphasized new technologies and chemical engineering techniques involved in processing petroleum products. Fluidized beds for hydro-treatment and biochemical processing, conversion of biomass to bio-oils and strategies for reducing emissions from Canadian energy facilities were some of the topics addressed.

  6. Chemical- and pathogen-induced programmed cell death in plants

    NARCIS (Netherlands)

    Iakimova, E.T.; Atanassov, A.; Woltering, E.J.

    2005-01-01

    This review focuses on recent update in the understanding of programmed cell death regarding the differences and similarities between the diverse types of cell death in animal and plant systems and describes the morphological and some biochemical determinants. The role of PCD in plant development an

  7. A Summer Leadership Development Program for Chemical Engineering Students

    Science.gov (United States)

    Simpson, Annie E.; Evans, Greg J.; Reeve, Doug

    2012-01-01

    The Engineering Leaders of Tomorrow Program (LOT) is a comprehensive curricular, co-curricular, extra-curricular leadership development initiative for engineering students. LOT envisions: "an engineering education that is a life-long foundation for transformational leaders and outstanding citizens." Academic courses, co-curricular certificate…

  8. Biological Defense Research Program

    Science.gov (United States)

    1989-04-01

    the data of Babudieri and Moscovici (54), C. burnetii is relatively resistant to ultraviolet rays; however, Siegert et al. (55) showed a marked...four viruses. J. Hyg., Camb. 59:479-484. 54. Babudieri, B., and Moscovici , C. 1952. Bandie Inst. Super. San. 15:215-219. 55. Siegert, R., Peter, H

  9. Disentangling detoxification: gene expression analysis of feeding mountain pine beetle illuminates molecular-level host chemical defense detoxification mechanisms.

    Science.gov (United States)

    Robert, Jeanne A; Pitt, Caitlin; Bonnett, Tiffany R; Yuen, Macaire M S; Keeling, Christopher I; Bohlmann, Jörg; Huber, Dezene P W

    2013-01-01

    The mountain pine beetle, Dendroctonus ponderosae, is a native species of bark beetle (Coleoptera: Curculionidae) that caused unprecedented damage to the pine forests of British Columbia and other parts of western North America and is currently expanding its range into the boreal forests of central and eastern Canada and the USA. We conducted a large-scale gene expression analysis (RNA-seq) of mountain pine beetle male and female adults either starved or fed in male-female pairs for 24 hours on lodgepole pine host tree tissues. Our aim was to uncover transcripts involved in coniferophagous mountain pine beetle detoxification systems during early host colonization. Transcripts of members from several gene families significantly increased in insects fed on host tissue including: cytochromes P450, glucosyl transferases and glutathione S-transferases, esterases, and one ABC transporter. Other significantly increasing transcripts with potential roles in detoxification of host defenses included alcohol dehydrogenases and a group of unexpected transcripts whose products may play an, as yet, undiscovered role in host colonization by mountain pine beetle.

  10. Disentangling detoxification: gene expression analysis of feeding mountain pine beetle illuminates molecular-level host chemical defense detoxification mechanisms.

    Directory of Open Access Journals (Sweden)

    Jeanne A Robert

    Full Text Available The mountain pine beetle, Dendroctonus ponderosae, is a native species of bark beetle (Coleoptera: Curculionidae that caused unprecedented damage to the pine forests of British Columbia and other parts of western North America and is currently expanding its range into the boreal forests of central and eastern Canada and the USA. We conducted a large-scale gene expression analysis (RNA-seq of mountain pine beetle male and female adults either starved or fed in male-female pairs for 24 hours on lodgepole pine host tree tissues. Our aim was to uncover transcripts involved in coniferophagous mountain pine beetle detoxification systems during early host colonization. Transcripts of members from several gene families significantly increased in insects fed on host tissue including: cytochromes P450, glucosyl transferases and glutathione S-transferases, esterases, and one ABC transporter. Other significantly increasing transcripts with potential roles in detoxification of host defenses included alcohol dehydrogenases and a group of unexpected transcripts whose products may play an, as yet, undiscovered role in host colonization by mountain pine beetle.

  11. 26TH AFOSR Chemical & Atmospheric Sciences Program Review FY81.

    Science.gov (United States)

    1982-03-01

    Bernstein, and A. Yoshihara, Chem. Phys. Let?., 82, 138 (1981). "On the Phase Transition in Benzil," A. Yoshihara, W. 0. Wilber , E. R. Bernstein, and J. C...Korea) 7. JUNIOR RESEARCH PERSONIEL: r. Ken Kosnik 8. PUBLICATIONS: S,4olecular BeaUm Sampling," A. J. Colussi and Sidney W. Benson, Int. J. Chem...of C2H4DCl. A Chemical Clock to Explore Highly Excited Molecules," P. J. Papagiannakopoulos, Ken Kosnik, and Sidney W. Benson, Int. J. Chem. Kin. (1982

  12. Progressively Fostering Students' Chemical Information Skills in a Three-Year Chemical Engineering Program in France

    Science.gov (United States)

    Gozzi, Christel; Arnoux, Marie-Jose´; Breuzard, Jere´my; Marchal, Claire; Nikitine, Clémence; Renaudat, Alice; Toulgoat, Fabien

    2016-01-01

    Literature searches are essential for scientists. Thus, courses on how to do a good literature search have been integrated in studies at CPE Lyon for many years. Recently, we modified our pedagogical approach in order to initiate students progressively in the search for chemical information. In addition, this new teaching organization is now based…

  13. Chemical Defence in a Millipede: Evaluation and Characterization of Antimicrobial Activity of the Defensive Secretion from Pachyiulus hungaricus (Karsch, 1881) (Diplopoda, Julida, Julidae).

    Science.gov (United States)

    Stanković, Slaviša; Dimkić, Ivica; Vujisić, Ljubodrag; Pavković-Lučić, Sofija; Jovanović, Zvezdana; Stević, Tatjana; Sofrenić, Ivana; Mitić, Bojan; Tomić, Vladimir

    2016-01-01

    The chemical defence of the millipede Pachyiulus hungaricus is reported in the present paper, in which a chemical characterization is given and antimicrobial activity is determined. In total, independently of sex, 44 compounds were identified. All compounds belong to two groups: quinones and pentyl and hexyl esters of long-chain fatty acids. The relative abundances of quinones and non-quinones were 94.7% vs. 5.3% (males) and 87.3% vs. 12.7% (females), respectively. The two dominant quinones in both sexes were 2-methyl-1,4,-benzoquinone and 2-methoxy-3-methyl-1,4-benzoquinone. Antibacterial and antifungal activity of the defensive secretion was evaluated in vitro against seven bacterial strains and eight fungal species. With the aid of a dilution technique, the antimicrobial potential of the secretion and high sensitivity of all tested strains were confirmed. The lowest minimum concentrations of these compounds (0.20-0.25 mg/mL) were sufficient for inhibition of Aeromonas hydrophila, Listeria monocytogenes and Methicillin resistant Staphylococcus aureus (MRSA). The growth of eight tested fungal species was inhibited by slightly lower concentrations of the secretion, with Fusarium equiseti as the most sensitive fungus and Aspergillus flavus as the most resistant. Values of MIC and MFC in the employed microdilution assay ranged from 0.10 to above 0.35 mg/mL. The given extract contains antimicrobial components potentially useful as therapeutic agents in the pharmaceutical and agricultural industries.

  14. The Effect of a 12-Week Moderate Intensity Interval Training Program on the Antioxidant Defense Capability and Lipid Profile in Men Smoking Cigarettes or Hookah: A Cohort Study

    Directory of Open Access Journals (Sweden)

    Abdessalem Koubaa

    2015-01-01

    Full Text Available Aim. To examine the impact of interval training program on the antioxidant defense capability and lipid profile in men smoking cigarettes or hookah unable or unwilling to quit smoking. Methods. Thirty-five participants performed an interval training (2 : 1 work : rest ratio 3 times a week for 12 weeks at an intensity of 70% of VO2max. All subjects were subjected to a biochemical test session before and after the training program. Results. The increase of total antioxidant status (TAS, glutathione peroxidase (GPx, and α-tocopherol, is significant only for cigarette smokers (CS and hookah smokers (HS groups. The decrease of malondialdehyde (MDA and the increase of glutathione reductase (GR are more pronounced in smokers groups compared to those of nonsmokers (NS. Superoxide dismutase (SOD increases in NS, CS, and HS groups by 10.1%, 19.5%, and 13.3%, respectively (P<0.001. Likewise, a significant improvement of high-density lipoprotein cholesterol (HDL-C and TC/HDL-C ratio was observed in CS and HS groups (P<0.05. Conclusion. Although the interval training program does not have a significant effect on blood lipid levels, it seems to be very beneficial in the defense and prevention programs of oxidative stress.

  15. Program Manager: Journal of the Defense Systems Management College. Volume 17, Number 4, July-August 1988

    Science.gov (United States)

    1988-08-01

    Senator Phil Gramm, ranking minority member, to advise the Senate Armed Services Committee Defense Industry and , . Technology Subcommittee on "...those... Crosby cisions concerning changes and others have translated to the process. general theories into prac- tical applications that are changing the corporate

  16. Evaluation of chloropentafluorobenzene as an intake simulant for chemical defense training. Final report, October 1991-October 1992

    Energy Technology Data Exchange (ETDEWEB)

    Clewell, H.J.; Jarnot, B.M.

    1993-01-01

    For a number of years the U.S. Air Force has been performing research to develop safe intake simulants for chemical warfare agents (CWA) to provide accurate and quantitative real-time assessment of troop proficiency and gear efficacy during chemical warfare (CW) field exercises. Chloropentafluorobenzene (CPFB) was identified and evaluated as a candidate inhalation simulant, and was determined to possess desirable physiochemical and toxicological properties. These include rapid uptake, low metabolism and toxicity, rapid and predictable clearance, real-time detectability by existing portable 'breathalyzer' technology and by fielded CWA detectors, realistic canister breakthrough and commercial availability. A physiologically based pharmacokinetic (PBPK) model for CPEB has been developed which accurately describes the time course of blood and exhaled air concentrations during and following inhalation exposures of rats and primates to CPFB. This model has been employed to predict human exhaled air concentrations for several hours following brief CPFB exposures, such as might be experienced in training exercises using CPFB as an intake simulant. These simulants could be used to determine the exhaled air concentrations at which personnel would have been incapacitated had the exposure been to a real agent. The PBPK model was also used to calculate internal dose measures for a quantitative assessment of safe exposure criteria for the use of CPFB in such exercises. To assure the safety of personnel it is recommended that field exercises be designed to avoid exposures greater than 30 parts per million (ppm), with the daily (8 h) time-weighted average not to exceed 3 ppm. The exposure guideline should not impair use of CPFB since field analytical methods can measure CPFB.

  17. Idaho Chemical programs annual technical report, fiscal year 1975

    Energy Technology Data Exchange (ETDEWEB)

    Buckham, J.A.; Bower, .R.; Struhs, R.T. (eds.)

    1976-06-01

    The operating experience in fuel processing, waste calcining, and other waste management activities at the ICPP for FY 1975 is summarized. A campaign of coprocessing zirconium and aluminum fuels to recover uranium, the second electrolytic processing campaign to convert recovered and purified uranyl nitrate solution to UO/sub 3/, and four operating periods of the Rare Gas Plant to recover /sup 85/Kr and xenon were successfully completed, with all systems functioning well except for minor difficulties. Support activities include laboratory-scale stability studies of various waste blends; particle size distribution studies of the ICPP stack; evaluation of possible remote radiation measuring methods; tests to estimate corrosion; treatment of fuel storage basin water; progress in development of processes for Rover and HTGR fuels; laboratory testing of filters that deteriorated during the sixth waste calcining campaign; visual inspection of the primary calciner vessel; tests to determine what causes ruthenium to volatilize; various studies in support of future fluidized-bed calcining operations; other waste management activities including studies of the collection and long-term storage of /sup 85/Kr, development of a suitable absorbent for /sup 129/I (I/sub 2/); and continuing studies in support of the proposed INEL facility for treating transuranic wastes. Research programs in other areas include: determining burnup for fast breeder reactor fuels, continued study of the iodine pathway, development of a fluidized-bed heat exchanger for use with geothermal waters, and involvement in the study of the natural fossil fission reactor at the Oklo mine in Gabon, West Africa.

  18. Biological and Chemical Security

    Energy Technology Data Exchange (ETDEWEB)

    Fitch, P J

    2002-12-19

    The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defense Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.

  19. A model for planning the chemical integrated system under uncertainty by the grey programming approach

    DEFF Research Database (Denmark)

    Ren, Jingzheng; Tan, Shiyu; Dong, Lichun

    2013-01-01

    A model to optimize the planning of the chemical integrated system comprised by multi-devices and multi-products has been proposed in this paper. With the objective to make more profits, the traditional model for optimizing production planning has been proposed. The price of chemicals, the market...... demand, and the production capacity have been considered as mutative variables, then an improved model in which some parameters are not constant has been developed and a new method to solve the grey linear programming has been proposed. In the grey programming model, the value of credibility can...

  20. Twelfth symposium on biotechnology for fuels and chemicals: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Scheitlin, F.M. (ed.)

    1990-01-01

    This report is the program and abstracts of the twelfth symposium on biotechnology for fuels and chemicals, held on May 7--11, 1990, at Gatlinburg, Tennessee. The symposium, sponsored by the Department of Energy, Oak Ridge National Laboratory, Solar Energy Research Institute, Badger Engineers, Inc., Gas Research Institute, and American Chemical Society, consists of five sessions: Session 1, thermal, chemical, and biological processing; Session 2 and 3, applied biological research; Session 4, bioengineering research; and Session 5, biotechnology, bioengineering, and the solution of environmental problems. It also consists of a poster session of the same five subject categories.

  1. AICD -- Advanced Industrial Concepts Division Biological and Chemical Technologies Research Program. 1993 Annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, G.; Bair, K.; Ross, J. [eds.

    1994-03-01

    The annual summary report presents the fiscal year (FY) 1993 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1993 (ASR 93) contains the following: A program description (including BCTR program mission statement, historical background, relevance, goals and objectives), program structure and organization, selected technical and programmatic highlights for 1993, detailed descriptions of individual projects, a listing of program output, including a bibliography of published work, patents, and awards arising from work supported by BCTR.

  2. Regulatory and Other Trends Relevant to Acquisition and Planning for the Future Defense Industrial Base

    Science.gov (United States)

    2011-05-01

    Acquisition and Planning for the Future Defense Industrial Base 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...expanding  SB 484 and 1379 -- CA, 2005 and 2006, disclosure of chemicals in cosmetics and US’s first bio-monitoring program cataloguing human exposure to...Biomonitoring shows bioaccumulation of chemicals in humans and animal kingdom  New understanding of intergenerational effects  Public/worker

  3. Phenylpropanoid enzymes, phenolic polymers and metabolites as chemical defenses to infection of Pratylenchus coffeae in roots of resistant and susceptible bananas (Musa spp.).

    Science.gov (United States)

    Vaganan, M Mayil; Ravi, I; Nandakumar, A; Sarumathi, S; Sundararaju, P; Mustaffa, M M

    2014-03-01

    Activity differences of the first (phenylalanine ammonia lyase, PAL) and the last (cinnamyl alcohol dehydrogenase, CAD) enzymes of phenylpropanoid pathway in the roots of resistant (Yangambi Km5 and Anaikomban) and susceptible (Nendran and Robusta) banana cultivars caused by root lesion nematode, Pratylenchus coffeae, were investigated. Also, the accumulation of phenolics and deposition of lignin polymers in cell walls in relation to resistance of the banana cultivars to the nematode were analyzed. Compared to the susceptible cultivars, the resistant cultivars had constitutively significantly higher PAL activity and total soluble and cell wall-bound phenolics than in susceptible cultivars. The resistant cultivars responded strongly to the infection of the nematode by induction of several-time higher PAL and CAD enzymes activities, soluble and wall-bound phenolics and enrichment of lignin polymers in cell wall and these biochemical parameters reached maximum at 7th day postinoculation. In addition, profiles of phenolic acid metabolites in roots of Yangambi Km5 and Nendran were analyzed by HPLC to ascertain the underlying biochemical mechanism of bananas resistance to the nematode. Identification and quantification of soluble and cell wall-bound phenolic acids showed six metabolites and only quantitative, no qualitative, differences occurred between the resistant and susceptible cvs. and between constitutive and induced contents. A very prominent increase of p-coumaric, ferulic and sinapic acids, which are precursors of monolignols of lignin, in resistant cv. was found. These constitutive and induced biochemical alterations are definitely the chemical defenses of resistant cvs. to the nematode infection.

  4. Implementation of flowsheet change to minimize hydrogen and ammonia generation during chemical processing of high level waste in the Defense Waste Processing Facility

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, Dan P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Woodham, Wesley H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Williams, Matthew S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Newell, J. David [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Luther, Michelle C. [Auburn Univ., AL (United States); Brandenburg, Clayton H. [Univ.of South Carolina, Columbia, SC (United States)

    2016-09-27

    Testing was completed to develop a chemical processing flowsheet for the Defense Waste Processing Facility (DWPF), designed to vitrify and stabilize high level radioactive waste. DWPF processing uses a reducing acid (formic acid) and an oxidizing acid (nitric acid) to rheologically thin the slurry and complete the necessary acid base and reduction reactions (primarily mercury and manganese). Formic acid reduces mercuric oxide to elemental mercury, allowing the mercury to be removed during the boiling phase of processing through steam stripping. In runs with active catalysts, formic acid can decompose to hydrogen and nitrate can be reduced to ammonia, both flammable gases, due to rhodium and ruthenium catalysis. Replacement of formic acid with glycolic acid eliminates the generation of rhodium- and ruthenium-catalyzed hydrogen and ammonia. In addition, mercury reduction is still effective with glycolic acid. Hydrogen, ammonia and mercury are discussed in the body of the report. Ten abbreviated tests were completed to develop the operating window for implementation of the flowsheet and determine the impact of changes in acid stoichiometry and the blend of nitric and glycolic acid as it impacts various processing variables over a wide processing region. Three full-length 4-L lab-scale simulations demonstrated the viability of the flowsheet under planned operating conditions. The flowsheet is planned for implementation in early 2017.

  5. Implementation of flowsheet change to minimize hydrogen and ammonia generation during chemical processing of high level waste in the defense waste processing facility

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, Dan P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Woodham, Wesley H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Williams, Matthew S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Newell, J. David [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Luther, Michelle C. [Auburn Univ., AL (United States); Brandenburg, Clayton H. [Univ.of South Carolina, Columbia, SC (United States)

    2016-09-27

    Testing was completed to develop a chemical processing flowsheet for the Defense Waste Processing Facility (DWPF), designed to vitrify and stabilize high level radioactive waste. DWPF processing uses a reducing acid (formic acid) and an oxidizing acid (nitric acid) to rheologically thin the slurry and complete the necessary acid base and reduction reactions (primarily mercury and manganese). Formic acid reduces mercuric oxide to elemental mercury, allowing the mercury to be removed during the boiling phase of processing through steam stripping. In runs with active catalysts, formic acid can decompose to hydrogen and nitrate can be reduced to ammonia, both flammable gases, due to rhodium and ruthenium catalysis. Replacement of formic acid with glycolic acid eliminates the generation of rhodium- and ruthenium-catalyzed hydrogen and ammonia. In addition, mercury reduction is still effective with glycolic acid. Hydrogen, ammonia and mercury are discussed in the body of the report. Ten abbreviated tests were completed to develop the operating window for implementation of the flowsheet and determine the impact of changes in acid stoichiometry and the blend of nitric and glycolic acid as it impacts various processing variables over a wide processing region. Three full-length 4-L lab-scale simulations demonstrated the viability of the flowsheet under planned operating conditions. The flowsheet is planned for implementation in early 2017.

  6. Program Manager: The Journal of the Defense Systems Management College. Volume 12, Number 6, November-December 1983,

    Science.gov (United States)

    1983-12-01

    of new technologies. In a recent Army conducted in-depth reviews of a small number of systems to Science Board report on artificial intelligence and...their busines addresses) to th Editor-in-Chief. Nongovernment employeas and organizations may I at $14 mmuly thrg the Superintendent of Documents, U.S...reason, we The job of all of us in the defense ac- the Affordable Acquisition Approach, must make intelligent decisions about quisition community is to

  7. Program Manager: The Journal of the Defense Systems Management College. Volume 12, Number 3, May-June 1983.

    Science.gov (United States)

    1983-01-01

    service groups, education, and professional organiza- tions. When we apply the ratio, we usually express it as an busine index in which the current...financial leverage. accept artificially low contract profits, he will react by striv- ing to increase profitability. This translates into low levels...Officer, MCC Corporation, and former deputy cited Refe e director of the Central Intelligence Agency. 1. On April 30, 1981, Deputy Secretary of Defense

  8. Prioritization of chemical hazards in spices and herbs for European monitoring programs

    NARCIS (Netherlands)

    Asselt, Van E.D.; Banach, J.L.; Fels, van der Ine

    2016-01-01

    Monitoring programs are preferably risk-based, which allows focusing on the most relevant human health risks. In this study, a risk matrix was used to identify those chemical hazards that have the highest human health risk for the following spices and herbs: paprika/chilli powder, black pepper, nutm

  9. 78 FR 17680 - Information Collection Request; Chemical Facility Anti-Terrorism Standards Personnel Surety Program

    Science.gov (United States)

    2013-03-22

    ... SECURITY Information Collection Request; Chemical Facility Anti-Terrorism Standards Personnel Surety...-Terrorism Standards (CFATS) Personnel Surety Program pursuant to 6 CFR 27.230(a)(12)(iv). \\1\\ A 60-day...-terrorism Vulnerability Information (CVI),\\2\\ Sensitive Security Information (SSI),\\3\\ or Protected...

  10. Toxicity characterization of environmental chemicals by the US National Toxicology Program: an overview.

    Science.gov (United States)

    Chhabra, Rajendra S; Bucher, John R; Wolfe, Mary; Portier, Christopher

    2003-08-01

    The US National Toxicology Program (NTP) is an interagency program whose mission is to evaluate agents of public health concern by developing and applying the tools of modern toxicology and molecular biology. Chemicals substances or physical agents selected for toxicology and carcinogenesis evaluations by the NTP are usually studied in a series of subacute (14-day exposure), subchronic (90-day exposure) and chronic (2-year exposure) studies in rodents. The NTP has published more than 500 reports of the findings and conclusions from its toxicology and carcinogenesis studies. In more specialized studies, the NTP also evaluates adverse effects on the structure and function of the immune, reproductive, nervous, and respiratory systems. The program attempts to evaluate and appropriately incorporate new technologies to improve the way we study the toxicity of chemicals. For example, the program has extensively evaluated several transgenic mouse models for their potential use as short-term cancer screens and has been a full participant in an international effort to examine their usefulness in pharmaceutical registration. Toxicogenomics, an emerging scientific field that examines the expression of thousands of genes simultaneously in response to chemical exposure, holds promise for future application to better understand the underlying mechanisms of chemical toxicity. A number of public health issues being addressed by the NTP are not only of national importance but also have global impact, such as the potential for endocrine disruptors to influence development and carcinogenesis and the safety of herbal medicines and dietary supplements. The program participates in the preparation of national and international toxicity testing guidelines and the findings from NTP studies are widely used for risk assessments by international organizations and federal agencies. The NTP maintains databases that contain toxicity, and health and safety information on a large number of

  11. Department of Defense Healthcare Management System Modernization (DHMSM)

    Science.gov (United States)

    2016-03-01

    2016 Major Automated Information System Annual Report Department of Defense Healthcare Management System Modernization (DHMSM) Defense...Secretary of Defense PB - President’s Budget RDT&E - Research, Development, Test, and Evaluation SAE - Service Acquisition Executive TBD - To Be...DSN Fax: Date Assigned: November 16, 2015 Program Information Program Name Department of Defense Healthcare Management System Modernization

  12. Computer program for calculation of complex chemical equilibrium compositions and applications. Part 1: Analysis

    Science.gov (United States)

    Gordon, Sanford; Mcbride, Bonnie J.

    1994-01-01

    This report presents the latest in a number of versions of chemical equilibrium and applications programs developed at the NASA Lewis Research Center over more than 40 years. These programs have changed over the years to include additional features and improved calculation techniques and to take advantage of constantly improving computer capabilities. The minimization-of-free-energy approach to chemical equilibrium calculations has been used in all versions of the program since 1967. The two principal purposes of this report are presented in two parts. The first purpose, which is accomplished here in part 1, is to present in detail a number of topics of general interest in complex equilibrium calculations. These topics include mathematical analyses and techniques for obtaining chemical equilibrium; formulas for obtaining thermodynamic and transport mixture properties and thermodynamic derivatives; criteria for inclusion of condensed phases; calculations at a triple point; inclusion of ionized species; and various applications, such as constant-pressure or constant-volume combustion, rocket performance based on either a finite- or infinite-chamber-area model, shock wave calculations, and Chapman-Jouguet detonations. The second purpose of this report, to facilitate the use of the computer code, is accomplished in part 2, entitled 'Users Manual and Program Description'. Various aspects of the computer code are discussed, and a number of examples are given to illustrate its versatility.

  13. Defense Acquisition Policy and Defense Industrial Base Reinforcement Strategy - Enhancing the International Competitiveness of the Korean National Defense Industry

    Science.gov (United States)

    2008-04-23

    Korea Defense Industry Association (KDIA). (2007). Annual management review of Korean Defense Industry. Seoul: Author. Lee, D.O. (2000...COMPETITIVENESS OF THE KOREAN NATIONAL DEFENSE INDUSTRY Published: 23 April 2008 by Dr. Dae Ok Lee 5th Annual Acquisition Research Symposium of the...International Competitiveness of the Korean National Defense Industry 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

  14. Department of Defense In-House RDT&E Activities. Management Analysis Report

    Science.gov (United States)

    1987-10-30

    Chemical Defense . . ... . 36 Medical Research Institute of Infectious Diseases . . , . 37 Missile Research, Development & Engineering Center ... . 38...EOD, STATISTICAL, MAINT EVALUATION, AND HUMAN FACTORS CAPABILITIES AVAILABLE. COMPUTER SUPPORT AVAILABLE. TEMPERATURES TO -50 DEG. FAHR . COMMON. 19... DISEASE ; MAMMALIAN AND IN VITRO TOXICOLOGY; FORWARD AREA CASUALTY CARE. ...CURRENT IMPORTANT PROGRAMS DETERMINATION OF SAFE THRESHOLDS OF COHERENT

  15. Computer Program for Calculation of Complex Chemical Equilibrium Compositions and Applications II. Users Manual and Program Description. 2; Users Manual and Program Description

    Science.gov (United States)

    McBride, Bonnie J.; Gordon, Sanford

    1996-01-01

    This users manual is the second part of a two-part report describing the NASA Lewis CEA (Chemical Equilibrium with Applications) program. The program obtains chemical equilibrium compositions of complex mixtures with applications to several types of problems. The topics presented in this manual are: (1) details for preparing input data sets; (2) a description of output tables for various types of problems; (3) the overall modular organization of the program with information on how to make modifications; (4) a description of the function of each subroutine; (5) error messages and their significance; and (6) a number of examples that illustrate various types of problems handled by CEA and that cover many of the options available in both input and output. Seven appendixes give information on the thermodynamic and thermal transport data used in CEA; some information on common variables used in or generated by the equilibrium module; and output tables for 14 example problems. The CEA program was written in ANSI standard FORTRAN 77. CEA should work on any system with sufficient storage. There are about 6300 lines in the source code, which uses about 225 kilobytes of memory. The compiled program takes about 975 kilobytes.

  16. Profile of the chemicals industry in California: Californiaindustries of the future program

    Energy Technology Data Exchange (ETDEWEB)

    Galitsky, Christina; Worrell, Ernst

    2004-06-01

    The U.S. Department of Energy (DOE) Office of Industrial Technologies (OIT) established the Industries of the Future (IOF) program to increase energy efficiency, reduce waste production and to improve competitiveness, currently focusing on nine sectors. The IOF is a partnership strategy involving industry, the research community and the government, working together to identify technology needs, promote industrial partnerships and implement joint measures with all partners involved. The State Industries of the Future (SIOF) program delivers the accomplishments of the national Industries of the Future strategy to the local level, to expand the technology opportunities to a larger number of partners and reach smaller businesses and manufacturers that were not initially involved in the IOF effort. The state programs bring together industry, academia, and state agencies to address the important issues confronting industry in the state. These public-private coalitions facilitate industry solutions locally and enhance economic development. California has started a State Industries of the Future effort, in collaboration with the U.S. Department of Energy. The California Energy Commission (CEC) is leading the SIOF program in California, as part of many other programs to improve the energy efficiency and performance of industries in California. The California State IOF program aims to build a network of participants from industry, academia and government in four selected industrial sectors as a basis for the development of a strategic partnership for industrial energy efficient technology in the state. In California the IOF effort focuses petroleum refining, chemical processing, food processing and electronics. As part of this effort, the SIOF program will develop roadmaps for technology development for the selected sectors. On the basis of the roadmap, the program will develop successful projects with co-funding from state and federal government, and promote industry

  17. Profile of the chemicals industry in California: Californiaindustries of the future program

    Energy Technology Data Exchange (ETDEWEB)

    Galitsky, Christina; Worrell, Ernst

    2004-06-01

    The U.S. Department of Energy (DOE) Office of Industrial Technologies (OIT) established the Industries of the Future (IOF) program to increase energy efficiency, reduce waste production and to improve competitiveness, currently focusing on nine sectors. The IOF is a partnership strategy involving industry, the research community and the government, working together to identify technology needs, promote industrial partnerships and implement joint measures with all partners involved. The State Industries of the Future (SIOF) program delivers the accomplishments of the national Industries of the Future strategy to the local level, to expand the technology opportunities to a larger number of partners and reach smaller businesses and manufacturers that were not initially involved in the IOF effort. The state programs bring together industry, academia, and state agencies to address the important issues confronting industry in the state. These public-private coalitions facilitate industry solutions locally and enhance economic development. California has started a State Industries of the Future effort, in collaboration with the U.S. Department of Energy. The California Energy Commission (CEC) is leading the SIOF program in California, as part of many other programs to improve the energy efficiency and performance of industries in California. The California State IOF program aims to build a network of participants from industry, academia and government in four selected industrial sectors as a basis for the development of a strategic partnership for industrial energy efficient technology in the state. In California the IOF effort focuses petroleum refining, chemical processing, food processing and electronics. As part of this effort, the SIOF program will develop roadmaps for technology development for the selected sectors. On the basis of the roadmap, the program will develop successful projects with co-funding from state and federal government, and promote industry

  18. A system analysis of the recruitment and retention problems associated with the program manager for chemical demilitarization

    OpenAIRE

    2001-01-01

    The primary purpose of this thesis is to investigate the problems of retaining qualified personnel in the Program Manager for Chemical Demilitarization organization through the end date of the program. To accomplish this the Program Manager for Chemical Demilitarization organization was analyzed from an open system prospective to identify the elements within the organization, and in the larger organizational environment, that are expected to contribute to the retention problem. In addition th...

  19. Quality control of meteorological data for the chemical stockpile emergency preparedness program.

    Energy Technology Data Exchange (ETDEWEB)

    Liljegren, J.C.; Tschopp, S.; Rogers, K.; Wasmer, F.; Liljegren, L.; Myirski, M.; Decision and Information Sciences; U.S. Army Chemical Materials Agency

    2009-08-01

    The Chemical Stockpile Emergency Preparedness Program Meteorological Support Project ensures the accuracy and reliability of data acquired by meteorological monitoring stations located at seven U.S. Army chemical weapons depots where storage and weapons destruction (demilitarization) activities are ongoing. The data are delivered in real time to U.S. Army plume dispersion models, which are used to plan for and respond to a potential accidental release of a chemical weapons agent. The project provides maintenance, calibration, and audit services for the instrumentation; collection, automated screening, visual inspection, and analysis of the data; and problem reporting and tracking to carefully control the data quality. The resulting high-quality meteorological data enhance emergency response modeling and public safety.

  20. U.S. Department of Energy Space and Defense Power Systems Program Ten-Year Strategic Plan, Volume 1 and Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Dwight, Carla

    2013-06-01

    The Department of Energy's Space and Defense Power Systems program provides a unique capability for supplying power systems that function in remote or hostile environments. This capability has been functioning since the early 1960s and counts the National Aeronautics and Space Administration as one of its most prominent customers. This enabling technology has assisted the exploration of our solar system including the planets Jupiter, Saturn, Mars, Neptune, and soon Pluto. This capability is one-of-kind in the world in terms of its experience (over five decades), breadth of power systems flown (over two dozen to date) and range of power levels (watts to hundreds of watts). This document describes the various components of that infrastructure, work scope, funding needs, and its strategic plans going forward.

  1. Protein structural information derived from NMR chemical shift with the neural network program TALOS-N.

    Science.gov (United States)

    Shen, Yang; Bax, Ad

    2015-01-01

    Chemical shifts are obtained at the first stage of any protein structural study by NMR spectroscopy. Chemical shifts are known to be impacted by a wide range of structural factors, and the artificial neural network based TALOS-N program has been trained to extract backbone and side-chain torsion angles from (1)H, (15)N, and (13)C shifts. The program is quite robust and typically yields backbone torsion angles for more than 90 % of the residues and side-chain χ 1 rotamer information for about half of these, in addition to reliably predicting secondary structure. The use of TALOS-N is illustrated for the protein DinI, and torsion angles obtained by TALOS-N analysis from the measured chemical shifts of its backbone and (13)C(β) nuclei are compared to those seen in a prior, experimentally determined structure. The program is also particularly useful for generating torsion angle restraints, which then can be used during standard NMR protein structure calculations.

  2. Evidence on the Effect of DoD Acquisition Policy and Process on Cost Growth of Major Defense Acquisition Programs

    Science.gov (United States)

    2014-09-01

    reports the number of programs with an average PAUC growth of at least 50 percent. Of the fifty -four programs that passed MS II/B in a Relatively...six cases ( shaded rows). In all but one of these cases (Joint Direct Attack Munition, or JDAM) the differences are absolutely or relatively small. The...same pattern. The average of the DLC estimates is 73 percent, and four of them ( shaded rows) are less than the PA&E estimate for the program, three

  3. A Computer-Aided Instruction Program for Teaching the TOPS20-MM Facility on the DDN (Defense Data Network)

    Science.gov (United States)

    1988-06-01

    provide learning-by-doing, which means a student aquires knowledge by solving real-world problems [Ref. 21. To tutor well, a system has to specify...apply artificial intelligence (AI) techniques. AI research such as natural- language understanding, knowledge representation, and inferencing, have been...programming language by providing a programming environment and online help facility. It has a tutoring module called Soft Tutor that examines the

  4. Robust automated mass spectra interpretation and chemical formula calculation using mixed integer linear programming.

    Science.gov (United States)

    Baran, Richard; Northen, Trent R

    2013-10-15

    Untargeted metabolite profiling using liquid chromatography and mass spectrometry coupled via electrospray ionization is a powerful tool for the discovery of novel natural products, metabolic capabilities, and biomarkers. However, the elucidation of the identities of uncharacterized metabolites from spectral features remains challenging. A critical step in the metabolite identification workflow is the assignment of redundant spectral features (adducts, fragments, multimers) and calculation of the underlying chemical formula. Inspection of the data by experts using computational tools solving partial problems (e.g., chemical formula calculation for individual ions) can be performed to disambiguate alternative solutions and provide reliable results. However, manual curation is tedious and not readily scalable or standardized. Here we describe an automated procedure for the robust automated mass spectra interpretation and chemical formula calculation using mixed integer linear programming optimization (RAMSI). Chemical rules among related ions are expressed as linear constraints and both the spectra interpretation and chemical formula calculation are performed in a single optimization step. This approach is unbiased in that it does not require predefined sets of neutral losses and positive and negative polarity spectra can be combined in a single optimization. The procedure was evaluated with 30 experimental mass spectra and was found to effectively identify the protonated or deprotonated molecule ([M + H](+) or [M - H](-)) while being robust to the presence of background ions. RAMSI provides a much-needed standardized tool for interpreting ions for subsequent identification in untargeted metabolomics workflows.

  5. Intra-plant differences in seaweed nutritional quality and chemical defenses: Importance for the feeding behavior of the intertidal amphipod Orchestoidea tuberculata

    Science.gov (United States)

    Duarte, Cristian; Acuña, Karin; Navarro, Jorge M.; Gómez, Iván

    2011-10-01

    As a result of their morphological complexity, large macroalgae show intra-thallus variations in their nutritional composition and secondary metabolite content, which influences the trophic ecology of herbivorous invertebrates, and ultimately their fitness. In this study, we evaluated for the first time the variability in nutritional quality (protein content, carbohydrates, lipids, and total organic matter), secondary metabolites (phlorotannins), and structure (shape and toughness) between blades and stipes of the macroalgae Durvillaea Antarctica. Specifically, we looked at their effect on feeding preference, rate of consumption, absorption efficiency, and growth rate of the amphipod Orchestoidea tuberculata, one of the most abundant organisms on Chilean sandy beaches. Proteins, carbohydrates, total organic matter and phlorotannin contents were significantly higher in blades than in stipes. Preference experiments revealed that the amphipods preferred blades when fresh pieces of blades and stipes were offered at the same time. Similar results were found when artificial food (in which structures of both parts of the alga were standardized) was offered, suggesting that shape and toughness of the two different parts of the alga did not influence preference patterns of O. tuberculata. Absorption efficiency of O. tuberculata was higher on blades compared to stipes. When the amphipods were kept with each of the algal parts separately (i.e. no choice), they consumed a significantly higher amount of stipe, which suggests that O. tuberculata used food quantity to compensate for the lower nutritional quality of stipes. The higher nutritional values of blades compared to stipes appears to explain observed preference patterns by O. tuberculata. Phlorotannin content did not appear to inhibit blade consumption, suggesting that the nutritional quality of the food could be more important than chemical defense in determining food choice in O. tuberculata. Growth did not differ

  6. 77 FR 35432 - Privacy Act of 1974, Computer Matching Program: United States Postal Service and the Defense...

    Science.gov (United States)

    2012-06-13

    ... Numbers, names, and dates of birth for TRS-enrolled Selected Reservists or TRR-enrolled Retired Reservists.... TRS Program--TRICARE Reserve Select, a premium based TRICARE military health plan for members of the... Retired Reserve, a premium based TRICARE military health plan for members of the Retired Reserve of...

  7. Three Approaches to Space Systems Acquisitions and their Application to the Defense Department’s Weather Satellite Program

    Science.gov (United States)

    2012-03-01

    by Toyota in the manufacturing world, such as just-in-time, kaizen , one-piece flow, jidoka, and heijunka. These techniques helped spawn the “lean...relentless reflection (hansei) and continuous improvement ( kaizen ) Similar to Principle 2, this principle shares similarity with space program

  8. Acquisition Program Risk Management: Does the Department of Defense Risk Management Practices Guide Provide an Effective Risk Tool for Program Managers in Today’s Acquisition Environment?

    Science.gov (United States)

    2012-05-01

    Management Definition ........................................................................................... 32 Table 16. Risk Management Tracking...Other (please specify) 5 Table 15. Risk Management Definition Question 7: Does your Program Office or Risk Management IPT track risks for cost...aligned to collect information on program risk definition. Question 6 was designed to collect information on risk management definition . Participants

  9. Nature's chemicals and synthetic chemicals: comparative toxicology.

    OpenAIRE

    Ames, B N; Profet, M; Gold, L S

    1990-01-01

    The toxicology of synthetic chemicals is compared to that of natural chemicals, which represent the vast bulk of the chemicals to which humans are exposed. It is argued that animals have a broad array of inducible general defenses to combat the changing array of toxic chemicals in plant food (nature's pesticides) and that these defenses are effective against both natural and synthetic toxins. Synthetic toxins such as dioxin are compared to natural chemicals, such as indole carbinol (in brocco...

  10. Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure

    Science.gov (United States)

    Mathews, David H.; Disney, Matthew D.; Childs, Jessica L.; Schroeder, Susan J.; Zuker, Michael; Turner, Douglas H.

    2004-01-01

    A dynamic programming algorithm for prediction of RNA secondary structure has been revised to accommodate folding constraints determined by chemical modification and to include free energy increments for coaxial stacking of helices when they are either adjacent or separated by a single mismatch. Furthermore, free energy parameters are revised to account for recent experimental results for terminal mismatches and hairpin, bulge, internal, and multibranch loops. To demonstrate the applicability of this method, in vivo modification was performed on 5S rRNA in both Escherichia coli and Candida albicans with 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluene sulfonate, dimethyl sulfate, and kethoxal. The percentage of known base pairs in the predicted structure increased from 26.3% to 86.8% for the E. coli sequence by using modification constraints. For C. albicans, the accuracy remained 87.5% both with and without modification data. On average, for these sequences and a set of 14 sequences with known secondary structure and chemical modification data taken from the literature, accuracy improves from 67% to 76%. This enhancement primarily reflects improvement for three sequences that are predicted with <40% accuracy on the basis of energetics alone. For these sequences, inclusion of chemical modification constraints improves the average accuracy from 28% to 78%. For the 11 sequences with <6% pseudoknotted base pairs, structures predicted with constraints from chemical modification contain on average 84% of known canonical base pairs. PMID:15123812

  11. Inducibility of chemical defences by two chewing insect herbivores in pine trees is specific to targeted plant tissue, particular herbivore and defensive trait.

    Science.gov (United States)

    Moreira, Xoaquín; Lundborg, Lina; Zas, Rafael; Carrillo-Gavilán, Amparo; Borg-Karlson, Anna-Karin; Sampedro, Luis

    2013-10-01

    There is increasing evidence that plants can react to biotic aggressions with highly specific responses. However, few studies have attempted to jointly investigate whether the induction of plant defences is specific to a targeted plant tissue, plant species, herbivore identity, and defensive trait. Here we studied those factors contributing to the specificity of induced defensive responses in two economically important pine species against two chewing insect pest herbivores. Juvenile trees of Pinus pinaster and P. radiata were exposed to herbivory by two major pest threats, the large pine weevil Hylobius abietis (a bark-feeder) and the pine processionary caterpillar Thaumetopoea pityocampa (a folivore). We quantified in two tissues (stem and needles) the constitutive (control plants) and herbivore-induced concentrations of total polyphenolics, volatile and non-volatile resin, as well as the profile of mono- and sesquiterpenes. Stem chewing by the pine weevil increased concentrations of non-volatile resin, volatile monoterpenes, and (marginally) polyphenolics in stem tissues. Weevil feeding also increased the concentration of non-volatile resin and decreased polyphenolics in the needle tissues. Folivory by the caterpillar had no major effects on needle defensive chemistry, but a strong increase in the concentration of polyphenolics in the stem. Interestingly, we found similar patterns for all these above-reported effects in both pine species. These results offer convincing evidence that induced defences are highly specific and may vary depending on the targeted plant tissue, the insect herbivore causing the damage and the considered defensive compound.

  12. Defense Research Enterprise Assessment

    Science.gov (United States)

    2017-01-01

    MEMORANDUM FOR: SEE DISTRIBUTION SUBJECT: Final Report of the Defense Science Board Task Force on Defense Research Enterprise Assessment The...attached report contains the findings and recommendations of the Defense Science Board (DSB) Study on Defense Research Enterprise Assessment. The 2015...National Defense Authorization Act directed the Secretary of Defense to task the DSB to conduct an assessment of the organization, missions, authorities

  13. Program Manager: Journal of the Defense Systems Management College, Volume 19, Number 6, November-December 1990

    Science.gov (United States)

    1990-12-01

    rejuvenated you’ll hear they are genuinely proud Western European Union (WEU) is # to be part of this determincd move- asserting itself as a unifying force I...corresponding to their vital interests economies through the benefits of for operating an open Europea , and their possibilities. Therefore open competition...EUROPEAN EUROPEAN COMMUNITY PROGRAM UNION GROUP COMMON REQUIREMENTS CAPS PANEL1 (ECONOMIES OF SCALE) I AND PROJECT I COORDINATION I (REDUCTION OF

  14. Program Manager - Journal of the Defense Systems Management College, Volume 24, Number 1, DSMC 124, January-February 1995.

    Science.gov (United States)

    1995-02-01

    and avi- contingencies, in the continental (Ret) Marquez ). onics equipment! We’re also relieved United States (CONUS) and over- of the need to put 50...TO THE EDITOR I read with interest the short discussion in the jul- Staff General Gabriel and then Secretary of the Air Aug 94 issue of Program...p. 21. Garcia , p. 17. * Why DoD Should Move Toward Commercial * Evolution of Configuration Management-William J. Practices-Dr. Walter B. LaBerge, p

  15. Further Evidence on the Effect of Acquisition Policy and Process on Cost Growth of Major Defense Acquisition Programs

    Science.gov (United States)

    2016-06-01

    reforms provide a plausible reason for expecting program outcomes, measured by cost growth, schedule slips, and performance shortfalls, to be better...procurement. C. Statistical Analysis of Average Cost Growth The statistical analysis presented here rests on definitions of periods delimited by...concerning which MDAPs are included in the database and the way in which cost growth is measured . These topics are developed in P-5126 and a companion to

  16. CDIO Projects in DTU’s Chemical and Biochemical B.Eng. Study Program

    DEFF Research Database (Denmark)

    Clement, Karsten; Harris, Pernille; Agersø, Yvonne

    2011-01-01

    The aim of this paper is to describe how the CDIO standards [1] have influenced the cross-disciplinary projects that are part of the study plan for the Chemical and Biochemical B.Eng. program. Four projects are described: The 1st semester design-build project on cleaning of waste water from a power...... plant, the 2nd semester laboratory project concerning antimicrobial resistant E. coli bacteria in retail meats, the 3rd semester project on unit operations in enzyme production, the 4th semester project on the fermentation and purification part of enzyme production....

  17. CHEMICALS

    CERN Multimedia

    Medical Service

    2002-01-01

    It is reminded that all persons who use chemicals must inform CERN's Chemistry Service (TIS-GS-GC) and the CERN Medical Service (TIS-ME). Information concerning their toxicity or other hazards as well as the necessary individual and collective protection measures will be provided by these two services. Users must be in possession of a material safety data sheet (MSDS) for each chemical used. These can be obtained by one of several means : the manufacturer of the chemical (legally obliged to supply an MSDS for each chemical delivered) ; CERN's Chemistry Service of the General Safety Group of TIS ; for chemicals and gases available in the CERN Stores the MSDS has been made available via EDH either in pdf format or else via a link to the supplier's web site. Training courses in chemical safety are available for registration via HR-TD. CERN Medical Service : TIS-ME :73186 or service.medical@cern.ch Chemistry Service : TIS-GS-GC : 78546

  18. DoD Emerging Contaminants Program

    Science.gov (United States)

    2011-03-28

    Acquisition, Technology and Logistics 1 DoD Emerging Contaminants Program Paul Yaroschak, Deputy Director Chemical & Material Risk Management Office...TITLE AND SUBTITLE DoD Emerging Contaminants Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...Harvard University – Ash Institute for Democratic Governance & Innovation Department of Defense Emerging Contaminants Program Acquisition, Technology and

  19. Program of technical assistance to the organization for the prohibition of chemical weapons, informal report

    Energy Technology Data Exchange (ETDEWEB)

    1995-01-01

    Currently, U.S. organizations provide technical support to the U.S. Delegation for its work as part of the Preparatory Commission (PrepCom) of the Organization for the Prohibition of Chemical Weapons (OPCW) in The Hague. The current efforts of the PrepCom are focussed on preparations for the Entry-Into-Force (EIF) of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons (often referred to as the {open_quotes}Chemical Weapons Convention{close_quotes} (CWC)). EIF of the CWC is expected in 1995, and shortly thereafter the PrepCom will cease to exist, with the OPCW taking over responsibilities under the CWC. A U.S. program of technical assistance to the OPCW for its verification responsibilities may be created as part of U.S. policy objectives after EIF of the CWC. In the summary below, comments by participants are presented in Square Brackets Some of the same points arose several times during the discussions; they are grouped together under the most pertinent heading.

  20. Theoretical research program to study chemical reactions in AOTV bow shock tubes

    Science.gov (United States)

    Taylor, Peter R.

    1993-01-01

    The main focus was the development, implementation, and calibration of methods for performing molecular electronic structure calculations to high accuracy. These various methods were then applied to a number of chemical reactions and species of interest to NASA, notably in the area of combustion chemistry. Among the development work undertaken was a collaborative effort to develop a program to efficiently predict molecular structures and vibrational frequencies using energy derivatives. Another major development effort involved the design of new atomic basis sets for use in chemical studies: these sets were considerably more accurate than those previously in use. Much effort was also devoted to calibrating methods for computing accurate molecular wave functions, including the first reliable calibrations for realistic molecules using full CI results. A wide variety of application calculations were undertaken. One area of interest was the spectroscopy and thermochemistry of small molecules, including establishing small molecule binding energies to an accuracy rivaling, or even on occasion surpassing, the experiment. Such binding energies are essential input to modeling chemical reaction processes, such as combustion. Studies of large molecules and processes important in both hydrogen and hydrocarbon combustion chemistry were also carried out. Finally, some effort was devoted to the structure and spectroscopy of small metal clusters, with applications to materials science problems.

  1. Survey of US Department of Defense Manufacturing Technology Program activities applicable to civilian manufacturing industries. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Azimi, S.A.; Conrad, J.L.; Reed, J.E.

    1985-03-01

    Intent of the survey was to identify and characterize activities potentially applicable to improving energy efficiency and overall productivity in the civilian manufacturing industries. The civilian industries emphasized were the general manufacturing industries (including fabricated metals, glass, machinery, paper, plastic, textile, and transportation equipment manufacturing) and the primary metals industries (including primary aluminum, copper, steel, and zinc production). The principal steps in the survey were to: develop overview taxonomies of the general manufacturing and primary metals industries as well as specific industry taxonomies; identify needs and opportunities for improving process energy efficiency and productivity in the industries included; identify federal programs, capabilities, and special technical expertise that might be relevant to industry's needs and opportunities; contact federal laboratories/facilities, through visits and other forms of inquiry; prepare formatted profiles (descriptions) potentially applicable work efforts; review findings with industry; and compile and evaluate industry responses.

  2. The Department of Defense Chemical, Biological, Nuclear and High Yield Explosive Response Enterprise: Have We Learned the Lessons to Ensure an Effective Response?

    Science.gov (United States)

    2011-06-10

    falling unconscious, and muscle spasms (Burke 2007, 126). There were a total of eleven deaths, fifty-four seriously injured, and over three-thousand...these are 27 also limited in number. One exercise called Operation Vibrant Response tested the DoD capability to respond to a radiological device in...support of FEMA and local and state agencies. Vibrant Response is a culminating exercise for Defense Support to Civil Authority operations conducted

  3. Idaho Chemical Processing Plant low-level waste grout stabilization development program FY-96 status report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.

    1996-09-01

    The general purpose of the Grout Stabilization Development Program is to solidify and stabilize the liquid low-level wastes (LLW) generated at the Idaho Chemical Processing Plant (ICPP). It is anticipated that LLW will be produced from the following: (1) chemical separation of the tank farm high-activity sodium-bearing waste; (2) retrieval, dissolution, and chemical separation of the aluminum, zirconium, and sodium calcines; (3) facility decontamination processes; and (4) process equipment waste. The main tasks completed this fiscal year as part of the program were chromium stabilization study for sodium-bearing waste and stabilization and solidification of LLW from aluminum and zirconium calcines. The projected LLW will be highly acidic and contain high amounts of nitrates. Both of these are detrimental to Portland cement chemistry; thus, methods to precondition the LLW and to cure the grout were explored. A thermal calcination process, called denitration, was developed to solidify the waste and destroy the nitrates. A three-way blend of Portland cement, blast furnace slag, and fly ash was successfully tested. Grout cubes were prepared at various waste loadings to maximize loading while meeting compressive strength and leach resistance requirements. For the sodium LLW, a 25% waste loading achieves a volume reduction of 3.5 and a compressive strength of 2,500 pounds per square inch while meeting leach, mix, and flow requirements. It was found that the sulfur in the slag reduces the chromium leach rate below regulatory limits. For the aluminum LLW, a 15% waste loading achieves a volume reduction of 8.5 and a compressive strength of 4,350 pounds per square inch while meeting leach requirements. Likewise for zirconium LLW, a 30% waste loading achieves a volume reduction of 8.3 and a compressive strength of 3,570 pounds per square inch.

  4. KINETICS: A computer program to analyze chemical reaction data. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Braun, R.L.; Burnham, A.K.

    1994-09-01

    KINETICS (Version 3.2) is a copyrighted, user-friendly kinetics analysis computer program designed for reactions such-as kerogen or polymer decomposition. It can fit rate parameters to chemical reaction data (rate or cumulative reacted) measured at a series of constant temperatures, constant heating rates, or arbitrary thermal histories. The program uses two models with conversion-dependent Azrhenius parameters and two models with activation energy distributions. The discrete distribution model fits an average frequency factor and relative fractions and activation energies for up to 25 parallel, fast-order reactions. The Gaussian distribution model fits a frequency factor, activation energy, Gaussian distribution parameter, and reaction order for up to 3 parallel reactions. For both distribution models, if the experiments are at a series of constant heating rates, the program uses a very fast approximate fitting procedure to determine possible initial parameter-estimates for the subsequent nonlinear regression analysis. This increases the probability that the regression analysis will properly. converge with a minimum of computer time. Once convergence is reached by the discrete model, the parameter space is further systematically searched to achieve global convergence. With the Gaussian model, the calculated rates or integrals can be convoluted with an experimental tracer signal during the nonlinear regression to account for dispersion effects often found in real chemical reaction data. KINETICS can also be used in an application mode to calculate reaction rates and integrals for previously determined Gaussian or discrete, parameters, using an arbitrary thermal history. Four additional models have been incorporated for the kinetics analysis of polymers and other materials, including some kerogens, which have a reaction-rate profile that is narrower than that for a single first-order reaction.

  5. A Network Security and Defense Program Based on Ad Hoc%一种基于Ad Hoc的网络安全防御方案

    Institute of Scientific and Technical Information of China (English)

    黄成兵; 陈明东

    2012-01-01

    Analying of Wireless Ad Hoc networks play an important role in society, and its facing a variety of security threats, this paper discusses the advantages and limitations of various network security solutions and technologies for wireless Ad Hoc networks , proposes an in-depth security defense program and explains its implementation process, while points out some of the problems of wireless Ad Hoc networks need to be resolved in the security field.%分析无线Ad Hoc网络在社会中发挥的重要作用及其面临的多种安全威胁,讨论目前各种网络安全解决方案和技术的优点及局限性,提出一种针对无线Ad Hoc网络的纵深安全防御方案并阐述其执行过程,同时指出无线Ad Hoc网络在安全领域急需解决的一些问题.

  6. Physcomitrella patens activates reinforcement of the cell wall, programmed cell death and accumulation of evolutionary conserved defense signals...upon Botrytis cinerea infection

    Science.gov (United States)

    The moss Physcomitrella patens is an evolutionarily basal model system suitable to analyze plant defense responses activated after pathogen assault. Upon infection with the necrotroph Botrytis cinerea (B. cinerea), several defense mechanisms are induced in P. patens, including the fortification of t...

  7. Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

    Science.gov (United States)

    Moreau, Thomas; Evans, Amanda L.; Vasquez, Louella; Tijssen, Marloes R.; Yan, Ying; Trotter, Matthew W.; Howard, Daniel; Colzani, Maria; Arumugam, Meera; Wu, Wing Han; Dalby, Amanda; Lampela, Riina; Bouet, Guenaelle; Hobbs, Catherine M.; Pask, Dean C.; Payne, Holly; Ponomaryov, Tatyana; Brill, Alexander; Soranzo, Nicole; Ouwehand, Willem H.; Pedersen, Roger A.; Ghevaert, Cedric

    2016-01-01

    The production of megakaryocytes (MKs)—the precursors of blood platelets—from human pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine. Here we describe an original approach for the large-scale generation of MKs in chemically defined conditions using a forward programming strategy relying on the concurrent exogenous expression of three transcription factors: GATA1, FLI1 and TAL1. The forward programmed MKs proliferate and differentiate in culture for several months with MK purity over 90% reaching up to 2 × 105 mature MKs per input hPSC. Functional platelets are generated throughout the culture allowing the prospective collection of several transfusion units from as few as 1 million starting hPSCs. The high cell purity and yield achieved by MK forward programming, combined with efficient cryopreservation and good manufacturing practice (GMP)-compatible culture, make this approach eminently suitable to both in vitro production of platelets for transfusion and basic research in MK and platelet biology. PMID:27052461

  8. Antioxidative defense

    Directory of Open Access Journals (Sweden)

    Stevanović Jelka

    2011-01-01

    Full Text Available Free radicals occur constantly during metabolism and take part in numerous physiological processes, such as: intra-cellular and inter-cellular signalization, gene expression, removal of damaged or senescent cells, and control of the tone of blood vessels. However, there is an increased quantity of free radicals in situations of so-called oxidative stress, when they cause serious damage to cellular membranes (peroxidation of their lipids, damage of membrane proteins, and similar, to interior cellular protein molecules, as well as DNA molecules and carbohydrates. This is precisely why the organism has developed numerous mechanisms for removing free radicals and/or preventing their production. Some of these are enzyme-related and include superoxide-dismutase, catalase, glutathione-peroxidase, and others. Other, non-enzyme mechanisms, imply antioxidative activities of vitamins E and C, provitamin A, coenzyme Q, reduced glutation, and others. Since free radicals can leave the cell that has produced them and become dispersed throughout the body, in addition to antioxidative defense that functions within cellular structures, antioxidant extra-cellular defense has also been developed. This is comprised by: transferrin, lactoferrin, haptoglobin, hemopexin, ceruloplasmin, albumins, extra-cellular isoform SOD, extracellular glutathione-peroxidase, glucose, bilirubin, urates, and many other molecules.

  9. Nanomaterials for Defense Applications

    Science.gov (United States)

    Turaga, Uday; Singh, Vinitkumar; Lalagiri, Muralidhar; Kiekens, Paul; Ramkumar, Seshadri S.

    Nanotechnology has found a number of applications in electronics and healthcare. Within the textile field, applications of nanotechnology have been limited to filters, protective liners for chemical and biological clothing and nanocoatings. This chapter presents an overview of the applications of nanomaterials such as nanofibers and nanoparticles that are of use to military and industrial sectors. An effort has been made to categorize nanofibers based on the method of production. This chapter particularly focuses on a few latest developments that have taken place with regard to the application of nanomaterials such as metal oxides in the defense arena.

  10. Defense Centers of Excellence for Psychological Health & Traumatic Brain Injury

    Science.gov (United States)

    ... Sign up Search: Defense Centers of Excellence For Psychological Health & Traumatic Brain Injury U.S. Department of Defense ... Reports Program Evaluation DoD/VA PH & TBI Registry Psychological Health About Psychological Health Psychological Health Resources About ...

  11. Molecular strategies of plant defense and insect counter-defense

    Institute of Scientific and Technical Information of China (English)

    KEYANZHU-SALZMAN; JIAN-LONGBI; TONG-XIANLIU

    2005-01-01

    The prediction of human population growth worldwide indicates there will be a need to substantially increase food production in order to meet the demand on food supply.This can be achieved in part by the effective management of insect pests. Since plants have co-evolved with herbivorous insects for millions of years, they have developed an array of defense genes to protect themselves against a wide variety of chewing and sucking insects.Using these naturally-occurring genes via genetic engineering represents an environmentally friendly insect pest-control measure. Insects, however, have been actively evolving adaptive mechanisms to evade natural plant defenses. Such evolved adaptability undoubtedly has helped insects during the last century to rapidly overcome a great many humanimposed management practices and agents, including chemical insecticides and genetically engineered plants. Thus, better understanding of the molecular and genetic basis of plant defense and insect counter-defense mechanisms is imperative, not only from a basic science perspective, but also for biotechnology-based pest control practice. In this review, we emphasize the recent advance and understanding of molecular strategies of attack-counterattack and defense-counter-defense between plants and their herbivores.

  12. Korean Defense Industry: Threat or Ally?

    Science.gov (United States)

    1994-02-22

    framework for defense industrial cooperation with Korea . While Senator Dixon eventually dropped his opposition and the Korean Fighter Program is now...US defense firms to transfer technology to Korean firms, the US Government must recognize two realities: first, Korea will develop indigenous...serious Korean competition in the foreseeable future. 8 It does not appear that the Korea defense industry is poised to take away significant market

  13. The use of thermal desorption in monitoring for the chemical weapons demilitarization program.

    Science.gov (United States)

    Harper, Martin

    2002-10-01

    Under international treaty, the United States and Russia are disposing of their aging stockpile of chemical weapons. Incineration and chemical neutralization are options for sites in the United States, although Russia prefers the latter. The storage and disposal of bulk and chemical agents and weapons involve unique hazards of handling extremely toxic materials. There are three major areas of concern--the storage stockpile, the disposal area, and the discovery and destruction of "found" material not considered part of the stockpile. Methods have been developed to detect the presence of chemical agents in the air, and these are used to help assure worker protection and the safety of the local population. Exposure limits for all chemical agents are low, sometimes nanograms per cubic meter for worker control limits and picograms per cubic meter for general population limits. There are three types of monitoring used in the USA: alarm, confirmation, and historical. Alarm monitors are required to give relatively immediate real-time responses to agent leaks. They are simple to operate and rugged, and provide an alarm in near real-time (generally a few minutes). Alarm monitors for the demilitarization program are based on sorbent pre-concentration followed by thermal desorption and simple gas chromatography. Alarms may need to be confirmed by another method, such as sample tubes collocated with the alarm monitor and analyzed in a laboratory by more sophisticated chromatography. Sample tubes are also used for historical perimeter monitoring, with sample periods typically of 12 h. The most common detector is the flame photometric detector, in sulfur or phosphorous mode, although others, such as mass-selective detectors, also have been used. All agents have specific problems with collection, chromatography and detection. Monitoring is not made easier by interferences from pesticide spraying, busy roadways or military firing ranges. Exposure limits drive the requirements for

  14. Programming chemical kinetics: engineering dynamic reaction networks with DNA strand displacement

    Science.gov (United States)

    Srinivas, Niranjan

    Over the last century, the silicon revolution has enabled us to build faster, smaller and more sophisticated computers. Today, these computers control phones, cars, satellites, assembly lines, and other electromechanical devices. Just as electrical wiring controls electromechanical devices, living organisms employ "chemical wiring" to make decisions about their environment and control physical processes. Currently, the big difference between these two substrates is that while we have the abstractions, design principles, verification and fabrication techniques in place for programming with silicon, we have no comparable understanding or expertise for programming chemistry. In this thesis we take a small step towards the goal of learning how to systematically engineer prescribed non-equilibrium dynamical behaviors in chemical systems. We use the formalism of chemical reaction networks (CRNs), combined with mass-action kinetics, as our programming language for specifying dynamical behaviors. Leveraging the tools of nucleic acid nanotechnology (introduced in Chapter 1), we employ synthetic DNA molecules as our molecular architecture and toehold-mediated DNA strand displacement as our reaction primitive. Abstraction, modular design and systematic fabrication can work only with well-understood and quantitatively characterized tools. Therefore, we embark on a detailed study of the "device physics" of DNA strand displacement (Chapter 2). We present a unified view of strand displacement biophysics and kinetics by studying the process at multiple levels of detail, using an intuitive model of a random walk on a 1-dimensional energy landscape, a secondary structure kinetics model with single base-pair steps, and a coarse-grained molecular model that incorporates three-dimensional geometric and steric effects. Further, we experimentally investigate the thermodynamics of three-way branch migration. Our findings are consistent with previously measured or inferred rates for

  15. Program of technical assistance to the Organization for the Prohibition of Chemical Weapons - lessons learned from the U.S. program of technical assistance to IAEA safeguards. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The Defense Nuclear Agency is sponsoring a technical study of the requirements of a vehicle to meet the OPCW`s future needs for enhanced chemical weapons verification capabilities. This report provides information about the proven mechanisms by which the U.S. provided both short- and long-term assistance to the IAEA to enhance its verification capabilities. Much of the technical assistance has generic application to international organizations verifying compliance with disarmament treaties or conventions. In addition, some of the equipment developed by the U.S. under the existing arrangements can be applied in the verification of other disarmament treaties or conventions. U.S. technical assistance to IAEA safeguards outside of the IAEA`s regular budget proved to be necessary. The U.S. technical assistance was successful in improving the effectiveness of IAEA safeguards for its most urgent responsibilities and in providing the technical elements for increased IAEA {open_quotes}readiness{close_quotes} for the postponed responsibilities deemed important for U.S. policy objectives. Much of the technical assistance was directed to generic subjects and helped to achieve a system of international verification. It is expected that the capabilities of the Organization for the Prohibition of Chemical Weapons (OPCW) to verify a state`s compliance with the {open_quotes}Chemical Weapons Convention{close_quotes} will require improvements. This report presents 18 important lessons learned from the experience of the IAEA and the U.S. Program of Technical Assistance to IAEA Safeguards (POTAS), organized into three tiers. Each lesson is presented in the report in the context of the difficulty, need and history in which the lesson was learned. Only the most important points are recapitulated in this executive summary.

  16. Synthetic Plant Defense Elicitors

    Directory of Open Access Journals (Sweden)

    Yasemin eBektas

    2015-01-01

    Full Text Available To defend themselves against invading pathogens plants utilize a complex regulatory network that coordinates extensive transcriptional and metabolic reprogramming. Although many of the key players of this immunity-associated network are known, the details of its topology and dynamics are still poorly understood. As an alternative to forward and reverse genetic studies, chemical genetics-related approaches based on bioactive small molecules have gained substantial popularity in the analysis of biological pathways and networks. Use of such molecular probes can allow researchers to access biological space that was previously inaccessible to genetic analyses due to gene redundancy or lethality of mutations. Synthetic elicitors are small drug like molecules that induce plant defense responses, but are distinct from known natural elicitors of plant immunity. While the discovery of the some synthetic elicitors had already been reported in the 1970s, recent breakthroughs in combinatorial chemical synthesis now allow for inexpensive high-throughput screens for bioactive plant defense-inducing compounds. Along with powerful reverse genetics tools and resources available for model plants and crop systems, comprehensive collections of new synthetic elicitors will likely allow plant scientists to study the intricacies of plant defense signaling pathways and networks in an unparalleled fashion. As synthetic elicitors can protect crops from diseases, without the need to be directly toxic for pathogenic organisms, they may also serve as promising alternatives to conventional biocidal pesticides, which often are harmful for the environment, farmers and consumers. Here we are discussing various types of synthetic elicitors that have been used for studies on the plant immune system, their modes-of-action as well as their application in crop protection.

  17. Global distribution of equatorial plasma bubbles in the premidnight sector during solar maximum as observed by KOMPSAT-1 and Defense Meteorological Satellite Program F15

    Science.gov (United States)

    Park, Jaeheung; Min, Kyoung Wook; Kim, Vitaly P.; Kil, Hyosub; Lee, Jae-Jin; Kim, Hee-Jun; Lee, Ensang; Lee, Dae Young

    2005-07-01

    We investigated the global distribution of equatorial plasma bubbles (EPBs) using in situ plasma density measurements from Korea Multipurpose Satellite-1 (KOMPSAT-1) and Defense Meteorological Satellite Program (DMSP) F15 during the solar maximum period from June 2000 to August 2001. The results were generally consistent with those of previous studies. EPBs were observed at all longitudes around the magnetic dip equator in the equinoctial seasons with the peak occurrence in the American-Atlantic-African regions. During the June solstice, EPBs occurred predominantly in the African sector, with enhancements in the magnetic north in the Indian and west Pacific regions, but were totally suppressed in the American-Atlantic sector. During the December solstice, EPBs occurred frequently in the American-Atlantic sector but were suppressed in the other longitude sectors, especially in the Pacific sector. The EPB occurrence probability was seen to be correlated with the observed topside plasma density and the model prereversal upward drift speed of ambient plasmas (Fejer et al., 1999), with their respective dominance dependent on the seasons. However, the peak EPB occurrence in the American-Atlantic sector during the December solstice was displaced somewhat from the region of peak density and upward drift, probably due to a strong solar terminator influence on the flux tube-integrated E region Pedersen conductivity and due to anomaly morphology. The peak EPB occurrence in the African sector during the June solstice is consistent only with the high ambient density in that region, for there was no coincidence with the maximum vertical drift or the minimum E region Pedersen conductivity.

  18. A Novel Approach for Modeling Chemical Reaction in Generalized Fluid System Simulation Program

    Science.gov (United States)

    Sozen, Mehmet; Majumdar, Alok

    2002-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a computer code developed at NASA Marshall Space Flight Center for analyzing steady state and transient flow rates, pressures, temperatures, and concentrations in a complex flow network. The code, which performs system level simulation, can handle compressible and incompressible flows as well as phase change and mixture thermodynamics. Thermodynamic and thermophysical property programs, GASP, WASP and GASPAK provide the necessary data for fluids such as helium, methane, neon, nitrogen, carbon monoxide, oxygen, argon, carbon dioxide, fluorine, hydrogen, water, a hydrogen, isobutane, butane, deuterium, ethane, ethylene, hydrogen sulfide, krypton, propane, xenon, several refrigerants, nitrogen trifluoride and ammonia. The program which was developed out of need for an easy to use system level simulation tool for complex flow networks, has been used for the following purposes to name a few: Space Shuttle Main Engine (SSME) High Pressure Oxidizer Turbopump Secondary Flow Circuits, Axial Thrust Balance of the Fastrac Engine Turbopump, Pressurized Propellant Feed System for the Propulsion Test Article at Stennis Space Center, X-34 Main Propulsion System, X-33 Reaction Control System and Thermal Protection System, and International Space Station Environmental Control and Life Support System design. There has been an increasing demand for implementing a combustion simulation capability into GFSSP in order to increase its system level simulation capability of a liquid rocket propulsion system starting from the propellant tanks up to the thruster nozzle for spacecraft as well as launch vehicles. The present work was undertaken for addressing this need. The chemical equilibrium equations derived from the second law of thermodynamics and the energy conservation equation derived from the first law of thermodynamics are solved simultaneously by a Newton-Raphson method. The numerical scheme was implemented as a User

  19. Identification of Chemicals of Interest to the Department of Defense and U.S. Air Force Among the U.S. Environmental Protection Agency’s Integrated Risk Information System Chemicals that are Due for Reassessment of their Toxicity Values

    Science.gov (United States)

    2010-03-16

    10-087, 16 March 2010 LIST OF ACRONYMS ATSDR Agency for Toxic Substances and Disease Registry CASRN Chemical Abstract Services Registry Number...included 473 chemicals with Chemical Abstract Services Registry Numbers (CASRNs) that are evaluated in this report (additional detail in Appendix A). The... Chemical Abstract Services Registry Numbers (CASRNs): 2,4-/2,6- dinitrotoluene mixture; refractory ceramic fibers; uranium, soluble salts; nickel, soluble

  20. A Medical Research and Evaluation Facility Defense and Studies Supporting the Medical Chemical Defense Program. Task 95-38: Evaluation of the Vesicating Properties of Neutralized Chemical Agent Identification Set (CAIS) Components.

    Science.gov (United States)

    1997-06-01

    3 ppm 10 ppm 2 ppm 5 ppm 4 ppm 14 ppm HN-1c (*)f (*)f 50 ppm 50 ppm HN- 1d (*)f (*)f 2 ppm 7 ppm 2 ppm 6 ppm LC (1)f (,)f 50 ppm 50 ppm L de (*)f (*)f...1_ SiteD_________ SiteE.• EZW /070 7-- •-,HQJ! 6 Site F A---WQ xiy Site G -4-7• . / , , . Form No. MREF-LESION.SIZ-07 D-26 LESION SIZE DETý

  1. IMPLEMENTATION OF A SAFETY PROGRAM FOR THE WORK ACCIDENTS’ CONTROL. A CASE STUDY IN THE CHEMICAL INDUSTRY

    Directory of Open Access Journals (Sweden)

    Edison Cesar de Faria Nogueira

    2015-03-01

    Full Text Available This article presents a case study related to the implementation of a Work Safety Program in a chemical industry, based on the Process Safety Program, PSP, of a huge energy company. The research was applied, exploratory, qualitative and with and data collection method through documentary and bibliographical research. There will be presented the main practices adopted in order to make the Safety Program a reality inside a chemical industry, its results and contributions for its better development. This paper proposes the implementation of a Safety Program must be preceded by a diagnosis of occupational safety and health management system and with constant critical analysis in order to make the necessary adjustments.

  2. Defense Acquisition Performance Assessment Report

    Science.gov (United States)

    2006-01-01

    Incorporated – “Changing the System” HeLLeR , TRiCiA A., Deputy Director of Congressional Support, Technical and Analytical Support, USAF A-Team...Interview Recorder” HeLLieR, RiCHARD, Director of Air Force Programs, United Technologies – “Joint Stars System” HeRMAN , DR. ROBeRT, Member, Defense

  3. Administrative and Technical Support for the U.S. Army Medical Research and Development Command Joint Working Group on Medical Chemical Defense

    Science.gov (United States)

    1989-08-01

    microproces;qor databaAing systems for monitoring project and contract reports and program technology trans. fers, coordinating and providing administratIvo ...performance assessment instruments, simulators and situational testers, technical reports, procedural manuals , and software and hardware developed by the JWGD...developed by the program. Databasing systems described below, software, procedual manuals . and hardcopy reports have been tranferred to WRAIR

  4. Specific and Optional Curriculum: An Experience in the Undergraduate Program of Chemical Engineering in Cienfuegos University, Cuba

    Science.gov (United States)

    Martínez, Yolanda García; Velázquez, Claudia Alvarado; Castillo, Rolando Delgado

    2016-01-01

    This paper pursues to define the pillars for designing the specific (SC) and optional curricula (OC) of Unit Operations and Processes (UOP) Discipline in the Chemical Engineering Program. To achieve this objective a methodology was developed, which was characterized by the participation of every member in the educational process: professors,…

  5. EM-21 ALTERNATIVE ENHANCED CHEMICAL CLEANING PROGRAM FOR SLUDGE HEEL REMOVAL

    Energy Technology Data Exchange (ETDEWEB)

    Hay, M; King, W; Martino, C

    2009-12-18

    Preliminary studies in the EM-21 Alternative Chemical Cleaning Program have focused on understanding the dissolution of Hematite (a primary sludge heel phase) in oxalic acid, with a focus on minimizing oxalic acid usage. Literature reviews, thermodynamic modeling, and experimental results have all confirmed that pH control, preferably using a supplemental proton source, is critical to oxalate minimization. With pH control, iron concentrations as high as 0.103 M have been obtained in 0.11 M oxalic acid. This is consistent with the formation of a 1:1 (iron:oxalate) complex. The solubility of Hematite in oxalic acid has been confirmed to increase by a factor of 3 when the final solution pH decreases from 5 to below 1. This is consistent with literature predictions of a shift in speciation from a 1:3 to 1:1 as the pH is lowered. Above a solution pH of 6, little Hematite dissolves. These results emphasize the importance of pH control in optimizing Hematite dissolution in oxalic acid.

  6. Guidance on health effects of toxic chemicals. Safety Analysis Report Update Program

    Energy Technology Data Exchange (ETDEWEB)

    Foust, C.B.; Griffin, G.D.; Munro, N.B.; Socolof, M.L.

    1994-02-01

    Martin Marietta Energy Systems, Inc. (MMES), and Martin Marietta Utility Services, Inc. (MMUS), are engaged in phased programs to update the safety documentation for the existing US Department of Energy (DOE)-owned facilities. The safety analysis of potential toxic hazards requires a methodology for evaluating human health effects of predicted toxic exposures. This report provides a consistent set of health effects and documents toxicity estimates corresponding to these health effects for some of the more important chemicals found within MMES and MMUS. The estimates are based on published toxicity information and apply to acute exposures for an ``average`` individual. The health effects (toxicological endpoints) used in this report are (1) the detection threshold; (2) the no-observed adverse effect level; (3) the onset of irritation/reversible effects; (4) the onset of irreversible effects; and (5) a lethal exposure, defined to be the 50% lethal level. An irreversible effect is defined as a significant effect on a person`s quality of life, e.g., serious injury. Predicted consequences are evaluated on the basis of concentration and exposure time.

  7. Endocrine Disruptor Screening Program (EDSP) Universe of Chemicals and General Validation Principles

    Science.gov (United States)

    This document was developed by the EPA to provide guidance to staff and managers regarding the EDSP universe of chemicals and general validation principles for consideration of computational toxicology tools for chemical prioritization.

  8. Evidence for a trade-off strategy in stone oak (Lithocarpus seeds between physical and chemical defense highlights fiber as an important antifeedant.

    Directory of Open Access Journals (Sweden)

    Xi Chen

    Full Text Available Trees in the beech or oak family (Fagaceae have a mutualistic relationship with scatter-hoarding rodents. Rodents obtain nutrients and energy by consuming seeds, while providing seed dispersal for the tree by allowing some cached seeds to germinate. Seed predation and caching behavior of rodents is primarily affected by seed size, mechanical protection, macronutrient content, and chemical antifeedants. To enhance seed dispersal, trees must optimize trade-offs in investment between macronutrients and antifeedants. Here, we examine this important chemical balance in the seeds of tropical stone oak species with two substantially different fruit morphologies. These two distinct fruit morphologies in Lithocarpus differ in the degree of mechanical protection of the seed. For 'acorn' fruit, a thin exocarp forms a shell around the seed while for 'enclosed receptacle' (ER fruit, the seed is embedded in a woody receptacle. We compared the chemical composition of numerous macronutrient and antifeedant in seeds from several Lithocarpus species, focusing on two pairs of sympatric species with different fruit morphologies. We found that macronutrients, particularly total non-structural carbohydrate, was more concentrated in seeds of ER fruits while antifeedants, primarily fibers, were more concentrated in seeds of acorn fruits. The trade-off in these two major chemical components was more evident between the two sympatric lowland species than between two highland species. Surprisingly, no significant difference in overall tannin concentrations in the seeds was observed between the two fruit morphologies. Instead, the major trade-off between macronutrients and antifeedants involved indigestible fibers. Future studies of this complex mutualism should carefully consider the role of indigestible fibers in the foraging behavior of scatter-hoarding rodents.

  9. Department of Defense In-House RDT&E Activities. Management Analysis Report: Department of the Army, Department of the Navy, Department of the Air Force

    Science.gov (United States)

    1985-10-30

    RESEARCH INSTITUTE OF CHEMICAL DEFENSE ..................... 43 MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES .................. 44 MISSILE...COMPUTER SUPPORT AVAILABLE.TEMPERATURES TO -50 DEG FAHR CONNON. 16 INSTALLATION: COMBAT SYSTEMS TEST ACTIVITY ABERDEEN PVG GRDMD CDR. COL RONALD V. HITE...FROM CHEM AGENT & VECTOR BORN DISEASE ; MAMMALIAN & IN VITRO TOXICOLOGY; FORWARD AREA CASUALTY CARE ... CURRENT IMPORTANT PROGRAMS DFTERMINATION OF SAFE

  10. Two Computer Programs for Equipment Cost Estimation and Economic Evaluation of Chemical Processes.

    Science.gov (United States)

    Kuri, Carlos J.; Corripio, Armando B.

    1984-01-01

    Describes two computer programs for use in process design courses: an easy-to-use equipment cost estimation program based on latest cost correlations available and an economic evaluation program which calculates two profitability indices. Comparisons between programed and hand-calculated results are included. (JM)

  11. Evidence on the Effect of DoD Acquisition Policy and Process and Funding Climate on Cancellations of Major Defense Acquisitions Programs

    Science.gov (United States)

    2015-05-01

    McNicol Sarah K. Burns Linda Wu Log : H 14-001307 IDA Paper P-5218 May 2015 INSTITUTE FOR DEFENSE ANALYSES 4850 Mark Center Drive Alexandria, Virginia... Dummy variables marked the other acquisition regimes and slope dummies were used to capture the effect of the different funding climates. We also

  12. Chemical Engineering Division fuel cycle programs. Progress report, January--March 1978

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M.J.; Ader, M.; Barletta, R.E.

    1979-04-01

    Fuel cycle studies reported for this period include studies of advanced solvent extraction techniques focussed on the development of centrifugal contactors for use in Purex processes. Miniature single-stage and eight-stage centrifugal contactors are being employed in studies of contactor performance and the kinetics of extraction. A 9-cm-ID centrifugal contactor has been completed, and fabrication drawings are being prepared for a plant-scale contactor. In other work, tricaprylmethyl-ammonium nitrate and di-n-amyl n-amylphosphonate are being evaluated as extractants in the Thorex process. Literature on the dispersion of liquids by explosions is being reviewed. A process was developed for extracting TBP degradation products from TBP-Na/sub 2/CO/sub 3/ scrub solutions while the actinides remain with the raffinate. In the program on pyrochemical and dry processing of nuclear fuel, the literature is being reviewed for acceptable materials for containment vessels, decladding methods are being evaluated, salt transport processes are being studied, a candidate flow sheet (based upon the Dow Aluminum Pyrometallurgical process) for reprocessing spent uranium metal fuel was prepared, work was begun on the use of molten salts for reprocessing actinide oxides, and the reprocessing of (Th,U)O/sub 2/ solid solution in a KCl-LiCl salt containing ThCl/sub 4/ and thorium chips was studied. Work on the encapsulation of solidified radioactive waste in a metal matrix includes study of (1) chemical interactions between simulated waste forms and matrix metals, (2) the leach rates of simulated encapsulated waste forms, and (3) the corrosion of candidate matrix metals and canister materials in brine solutions.Work to establish criteria for the handling of waste cladding hulls is continuing. The transport properties of nuclear waste in geologic media are being studied to estimate leaching of radionuclides from deep repositories by groundwater.

  13. Chemical Engineering Division fuel cycle programs. Quarterly progress report, October-December 1978

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M J; Ader, M; Barletta, R E

    1980-01-01

    In the program on pyrochemical and dry processing methods (PDPM) for nuclear fuel, tungsten crucibles were successfully spun for use in laboratory-scale experiments. Corrosion testing of refractory metals and alloys in PDPM environments was done. Ceramic substrates were successfully coated with tungsten. Solubility measurements were made to determine Cd/Mg alloy composition and temperature at which dissolved Th will precipitate. Experiments were started to study the reduction of high-fired ThO/sub 2/ with Ca in a molten metal-molten salt system. Work on the fused salt electrolysis of CaO was started. Equipment for determining phase diagrams for U-Cu-Mg system was set up. The reaction of UO/sub 2/ with molten equimolar NaNO/sub 3/-KNO/sub 3/ was studied as part of a project to identify chemically feasible nonaqueous fuel reprocessing methods. Work was continued on development of a flowsheet for reprocessing actinide oxides by extracting actinides into ammonium chloro-aluminate (and alternative salts) from a bismuth solution. Preparation of Th, U, and Pu nitrides after dissolution of spent fuel elements in molten tin is being studied. Leach rates of glass beads, pulverized beads, and beads encapsulated in a lead matrix with no protective envelope were studied. A method (employing no pressure or vacuum systems) of encapsulating various solid wastes in a lead metal matrix was developed and tested. A preliminary integration was made of earlier data on effects of impacts on metal-matrix waste forms.Leach migration experiments were compared with conventional infiltration experiments as methods of evaluating geologic formations as barriers to nuclide migration. The effect of the streaming potential on the rates of transport of radioactive I/sup -/ and Na/sup +/ through kaolinite columns was measured, as well as adsorption of iodide and iodate by several compounds; implications of the results upon the disposal of radioactive iodine are discussed.

  14. Research on Modeling of Allocation of Air Defense Troops Based on Programming Method%基于规划方法的防空兵兵力区分问题建模

    Institute of Scientific and Technical Information of China (English)

    蒋里强; 王桂花; 王纯; 高建军

    2014-01-01

    The allocation of air defense troops is an important step of troops disposition,a correct scheme about combat grouping and combat formation disposition could be worked out only after the allocation of air defense troops has been done. This paper is devoted to study allocation problem of troops during the process of coordination operation between ground -to -air missile forces and antiaircraft artillery forces within combat zone of air defense troops. Taking the mathematic expectation of destroying enemy air raid weapons as objective function,a nonlinear programming model is built and the optimal scheme of troops allocation is found to help commander make a policy by use of Lingo software.%防空兵兵力区分是防空兵兵力部署的一个重要环节,在进行正确的兵力区分基础上,才能进行正确的战斗编组和战斗队型配置。研究了防空兵作战地幅内地空导弹兵与高射炮兵协同作战时的兵力区分问题,以消灭敌空兵器的数学期望为目标函数,用规划方法建立了该问题的数学模型,用Lingo软件求出了兵力区分的最佳方案。

  15. Protect and Defend: Adequacy of the Department of Defense Role Prescribed in the Federal Response to a Chemical or Biological Attack Against the Homeland

    Science.gov (United States)

    2007-11-02

    freezing point depressants , and thickeners.131 Additionally, many of the design specifications for munitions and aerosol sprayers can be found in...indicated signs of PTSD up to 6 months after the incident.230 Symptoms included fear (32%), insomnia (29 percent), flashbacks (16 percent), depression ... Meltzer , and George P. Schmid, “The Economic Impact of a Bioterrorist Attack: Are Prevention and Postattack Intervention Programs Justifiable

  16. Large scale production of megakaryocytes from human pluripotent stem cells by a chemically defined forward programming approach

    OpenAIRE

    Moreau, Thomas; Evans, Amanda L.; Vasquez, Louella; Tijssen, Marloes R.; Yan, Ying; Trotter, Matthew W.; Howard, Daniel; Colzani, Maria; Arumugam, Meera; Wu, Wing Han; Dalby, Amanda; Lampela, Riina; Bouet, Guenaelle; Hobbs, Catherine M.; Dean C Pask

    2016-01-01

    This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Nature Publishing Group. The production of megakaryocytes (MKs) ? the precursors of blood platelets ? from human pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine. We describe an original approach for the large scale generation of MKs in chemically defined conditions using a forward programming strategy relying on the concurrent exogenous e...

  17. Large scale production of megakaryocytes from human pluripotent stem cells by a chemically defined forward programming approach

    OpenAIRE

    Moreau, Thomas; Evans, Amanda L.; Vasquez, Louella; Tijssen, Marloes R.; Yan, Ying; Trotter, Matthew W.; Howard, Daniel; Colzani, Maria; Arumugam, Meera; Wu, Wing Han; Dalby, Amanda; Lampela, Riina; Bouet, Guenaelle; Hobbs, Catherine M.; Dean C Pask

    2016-01-01

    This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Nature Publishing Group. The production of megakaryocytes (MKs) – the precursors of blood platelets – from human pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine. We describe an original approach for the large scale generation of MKs in chemically defined conditions using a forward programming strategy relying on the concurrent exogenous e...

  18. Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems.

    Directory of Open Access Journals (Sweden)

    Janarthanan Krishnamoorthy

    Full Text Available BACKGROUND: Nuclear Magnetic Resonance (NMR spectroscopy offers a variety of experiments to study protein-ligand interactions at atomic resolution. Among these experiments, 15N Heteronuclear Single Quantum Correlation (HSQCexperiment is simple, less time consuming and highly informative in mapping the binding site of the ligand. The interpretation of 15N HSQC becomes ambiguous when the chemical shift perturbations are caused by non-specific interactions like allosteric changes and local structural rearrangement. Under such cases, detailed chemical exchange analysis based on chemical shift perturbation will assist in locating the binding site accurately. METHODOLOGY/PRINCIPAL FINDINGS: We have automated the mapping of binding sites for fast chemical exchange systems using information obtained from 15N HSQC spectra of protein serially titrated with ligand of increasing concentrations. The automated program Auto-FACE (Auto-FAst Chemical Exchange analyzer determines the parameters, e.g. rate of change of perturbation, binding equilibrium constant and magnitude of chemical shift perturbation to map the binding site residues.Interestingly, the rate of change of perturbation at lower ligand concentration is highly sensitive in differentiating the binding site residues from the non-binding site residues. To validate this program, the interaction between the protein hBcl(XL and the ligand BH3I-1 was studied. Residues in the hydrophobic BH3 binding groove of hBcl(XL were easily identified to be crucial for interaction with BH3I-1 from other residues that also exhibited perturbation. The geometrically averaged equilibrium constant (3.0 x 10(4 calculated for the residues present at the identified binding site is consistent with the values obtained by other techniques like isothermal calorimetry and fluorescence polarization assays (12.8 x 10(4. Adjacent to the primary site, an additional binding site was identified which had an affinity of 3.8 times weaker

  19. Seventeenth symposium on biotechnology for fuels and chemicals. Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    This volume contains the abstracts of oral and poster presentations made at the Seventeenth Symposium on Biotechnology for Fuels and Chemicals. Session titles include Thermal, Chemical, and Biological Processing; Applied Biological Research; Bioprocessing Research; Special Topics Discussion Groups; Process Economics and Commercialization; and Environmental Biotechnology.

  20. Organic chemical aging mechanisms: An annotated bibliography. Waste Tank Safety Program

    Energy Technology Data Exchange (ETDEWEB)

    Samuels, W.D.; Camaioni, D.M.; Nelson, D.A.

    1993-09-01

    An annotated bibliography has been compiled of the potential chemical and radiological aging mechanisms of the organic constituents (non-ferrocyanide) that would likely be found in the UST at Hanford. The majority of the work that has been conducted on the aging of organic chemicals used for extraction and processing of nuclear materials has been in conjunction with the acid or PUREX type processes. At Hanford the waste being stored in the UST has been stabilized with caustic. The aging factors that were used in this work were radiolysis, hydrolysis and nitrite/nitrate oxidation. The purpose of this work was two-fold: to determine whether or not research had been or is currently being conducted on the species associated with the Hanford UST waste, either as a mixture or as individual chemicals or chemical functionalities, and to determine what areas of chemical aging need to be addressed by further research.

  1. Designing monitoring programs for chemicals of emerging concern in potable reuse ⋯ What to include and what not to include?

    KAUST Repository

    Drewes, Jorg

    2012-11-01

    This study discussed a proposed process to prioritize chemicals for reclaimed water monitoring programs, selection of analytical methods required for their quantification, toxicological relevance of chemicals of emerging concern regarding human health, and related issues. Given that thousands of chemicals are potentially present in reclaimed water and that information about those chemicals is rapidly evolving, a transparent, science-based framework was developed to guide prioritization of which compounds of emerging concern (CECs) should be included in reclaimed water monitoring programs. The recommended framework includes four steps: (1) compile environmental concentrations (e.g., measured environmental concentration or MEC) of CECs in the source water for reuse projects; (2) develop a monitoring trigger level (MTL) for each of these compounds (or groups thereof) based on toxicological relevance; (3) compare the environmental concentration (e.g., MEC) to the MTL; CECs with a MEC/MTL ratio greater than 1 should be prioritized for monitoring, compounds with a ratio less than \\'1\\' should only be considered if they represent viable treatment process performance indicators; and (4) screen the priority list to ensure that a commercially available robust analytical method is available for that compound. © IWA Publishing 2013.

  2. An analysis of Chemical Stockpile Emergency Preparedness Program exercise results. Volume 1: The CSEPP Exercise Results Database

    Energy Technology Data Exchange (ETDEWEB)

    Hewett, P.L. Jr.; Mitrani, J.E.; Absil-Mills, M.J.G.; Tallarovic, P.; Molsen, J.; Vercellone, J.; Madore, M.A.

    1998-06-01

    The primary focus of the Chemical Stockpile Emergency Preparedness Program (CSEPP) is to enhance the response capabilities of the eight US Army installations that store chemical weapons agent and of the communities immediately surrounding each Army storage installation. Exercises are a major component of the program and are conducted annually at each of the eight installations. Following each exercise, a report summarizing the results of the exercise is produced. To gain a better perspective on the site-specific and program-wide results of these exercises, the Project Manager for Chemical Stockpile Emergency Preparedness requested that Argonne National Laboratory develop a database containing the results of exercises held through June 1996. This document provides a summary of the process used to develop the CSEPP Exercise Results Database. The database provides CSEPP managers in the Department of the Army and the Federal Emergency Management Agency a method for tracking and analyzing exercise results. The report discusses the collection and coding of exercise data and provides tables to guide coding of future exercise results. An electronic copy of the database (CD-ROM) accompanies the report. This report focuses only on methods used to collect exercise data and develop the database; Volume 2 discusses the analysis of the data collected.

  3. Recognizing plant defense priming

    NARCIS (Netherlands)

    Martinez-Medina, A.; Flors, V.; Heil, M.; Mauch-Mani, B.; Pieterse, C.M.J.; Pozo, M.J.; Ton, J.; Van Dam, N.M.; Conrath, U.

    2016-01-01

    Defense priming conditions diverse plant species for the superinduction of defense, often resulting in enhanced pest and disease resistance and abiotic stress tolerance. Here, we propose a guideline that might assist the plant research community in a consistent assessment of defense priming in plant

  4. Proceedings of the U.S. Army Chemical Research, Development and Engineering Center Scientific Conference on Chemical Defense Research Held in Aberdeen Proving Ground, Maryland on 14-17 November 1989

    Science.gov (United States)

    1990-08-01

    Thermochemistry of High Energy Reactions ................ .......... 339 Eugene S. Domalski and Thomas L. Jobe, Jr. V. DETECTIO...Sharon A. Reutter, Nida Q. Legaspi, Robert D. Armstrong, and Robert J. Mioduszewski The Evaluation of a Synthetic Opiate Aerosol in Inducing Narcotic...HIGH ENERGY REACTIONS Eugene S. Domalski and Thomas L. Jobe, Jr. Chemical Thermodynamics Division National Institute of Standards and Technology

  5. Computer programming for nucleic acid studies. II. Total chemical shifts calculation of all protons of double-stranded helices.

    Science.gov (United States)

    Giessner-Prettre, C; Ribas Prado, F; Pullman, B; Kan, L; Kast, J R; Ts'o, P O

    1981-01-01

    A FORTRAN computer program called SHIFTS is described. Through SHIFTS, one can calculate the NMR chemical shifts of the proton resonances of single and double-stranded nucleic acids of known sequences and of predetermined conformations. The program can handle RNA and DNA for an arbitrary sequence of a set of 4 out of the 6 base types A,U,G,C,I and T. Data files for the geometrical parameters are available for A-, A'-, B-, D- and S-conformations. The positions of all the atoms are calculated using a modified version of the SEQ program [1]. Then, based on this defined geometry three chemical shift effects exerted by the atoms of the neighboring nucleotides on the protons of each monomeric unit are calculated separately: the ring current shielding effect: the local atomic magnetic susceptibility effect (including both diamagnetic and paramagnetic terms); and the polarization or electric field effect. Results of the program are compared with experimental results for a gamma (ApApGpCpUpU) 2 helical duplex and with calculated results on this same helix based on model building of A'-form and B-form and on graphical procedure for evaluating the ring current effects.

  6. Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program

    Data.gov (United States)

    U.S. Environmental Protection Agency — Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the...

  7. Eighteenth symposium on biotechnology for fuels and chemicals: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This volume provides the proceedings for the Eighteenth Symposium on Biotechnology for Fuels and Chemicals held May 5-9, 1996 in Gatlinburg, Tennessee. The proceedings contains abstracts for oral and poster presentations.

  8. National Status and Trends: Bioeffects Program - Southwest Puerto Rico Chemical Contaminant Assessment Summary

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of the project was to characterize the extent and magnitude of chemical contamination in southwest Puerto Rico, as part of a larger effort to link coral...

  9. Alternative Feedstocks Program Technical and Economic Assessment: Thermal/Chemical and Bioprocessing Components

    Energy Technology Data Exchange (ETDEWEB)

    Bozell, J. J.; Landucci, R.

    1993-07-01

    This resource document on biomass to chemicals opportunities describes the development of a technical and market rationale for incorporating renewable feedstocks into the chemical industry in both a qualitative and quantitative sense. The term "renewable feedstock?s" can be defined to include a huge number of materials such as agricultural crops rich in starch, lignocellulosic materials (biomass), or biomass material recovered from a variety of processing wastes.

  10. Investigating Iraq’s Chemical Warfare Program: Updated and Expanded Research Plan

    Science.gov (United States)

    2012-07-01

    chemical warfare, chemical weapons, Conflict Records Research Center, Tabun , Sarin, UN Sepcial Commission, UN UN Monitoring, Verification and Inspection...7 for tabun and sarin; and Ahmed 2 & 3 for production of precursors for tabun and sarin. The general contractor is Al Fao General Establishment that... tabun , and sarin. “mid- 1970s” Al Hazen Institute has by this time set up contacts with “30 major foreign organizations and companies” for securing

  11. The Application of Random Sampling System Based on VBA Programming in The Graduation Thesis Defense%基于VBA编程的随机抽题系统在毕业答辩中应用

    Institute of Scientific and Technical Information of China (English)

    侯伟; 吴锦杨; 娄晓明

    2016-01-01

    毕业答辩是大学生本科教育阶段整个学习过程中最后一道实践教学环节,本毕业答辩抽题系统结合VBA编程和微信公众号互联网技术,改变了传统毕业答辩环节中的纸质化抽签及抽题的形式,减少纸张及碳粉的消耗。本抽题系统可适用于毕业答辩、课堂教学互动、晚会现场抽奖、教学知识竞赛、面试随机抽题等需要随机抽签或抽题的场合。该系统能够使每一位在场用户通过投影仪屏幕同时看到随机所抽题目,相比传统纸质抽题更公平公正。%[Abstract]Graduation thesis defense is the last practice teaching link in the whole learning process of undergraduate education phase.This question system of graduation thesis defense combined with VBA programming and WeChat public Internet technology.It can not only change the draw and question form with paper in the traditional graduation reply link,but also reduce the consumption of paper and toner.This question system can be applied to many occasions.Such as graduation thesis defenses,interactive classroom-teaching,the lucky draw on the party,knowledge competition of teaching,random question on the interview and so on.The system allows each user to see the randomly drawing question through the projector screen. Compared with the traditional paper question,this system is more fair and square.

  12. FY2002 Progress Summary Program Plan, Statement of Work and Deliverables for Development of High Average Power Diode-Pumped Solid State Lasers, and Complementary Technologies, for Applications in Energy and Defense

    Energy Technology Data Exchange (ETDEWEB)

    Bayramian, A; Bibeau, C; Beach, R; Behrendt, B; Ebbers, C; Latkowski, J; Meier, W; Payne, S; Perkins, J; Schaffers, K; Skulina, K; Ditmire, T; Kelly, J; Waxer, L; Rudi, P; Randles, M; Witter, D; Meissner, H; Merissner, O

    2001-12-13

    The High Average Power Laser Program (HAPL) is a multi-institutional, coordinated effort to develop a high-energy, repetitively pulsed laser system for Inertial Fusion Energy and other DOE and DOD applications. This program is building a laser-fusion energy base to complement the laser-fusion science developed by DOE Defense programs over the past 25 years. The primary institutions responsible for overseeing and coordinating the research activities are the Naval Research Laboratory (NRL) and LLNL. The current LLNL proposal is a companion proposal to that submitted by NRL, for which the driver development element is focused on the krypton fluoride excimer laser option. Aside from the driver development aspect, the NRL and LLNL companion proposals pursue complementary activities with the associated rep-rated laser technologies relating to target fabrication, target injection, final optics, fusion chamber, materials and power plant economics. This report requests continued funding in FY02 to support LLNL in its program to build a 1kW, 100J, diode-pumped, crystalline laser. In addition, research in high gain laser target design, fusion chamber issues and survivability of the final optic element will be pursued. These technologies are crucial to the feasibility of inertial fusion energy power plants and also have relevance in rep-rated stewardship experiments.

  13. AFOSR (Air Force Office of Scientific Research) Chemical & Atmospheric Sciences Program Review (28th).

    Science.gov (United States)

    1983-06-01

    Potential of Corona John A. Bicknell Discharges From Aircraft Flying Institute of Science & Technology In Precipitation P.O. Box 88 AFOSR-83-0083...transformation-toughened zirconia , as well as whisker-, particle- and fiber-reinforced glass and polycrystalline ceramic matrices, * and chemically

  14. Influence of environmental chemicals on epigenetic programming and its applicability in human health risk assessment.

    Science.gov (United States)

    The field of epigenetics is rapidly evolving in response to the growing concern that heritable changes in gene expression may be involved in chemically-mediated adverse health outcomes, such as cancer. Although human and animal studies have shown a strong involvement of epigeneti...

  15. Plant antiherbivore defenses in Fabaceae species of the Chaco

    Directory of Open Access Journals (Sweden)

    T. E. Lima

    Full Text Available Abstract The establishment and maintenance of plant species in the Chaco, one of the widest continuous areas of forests in the South American with sharp climatic variations, are possibly related to biological features favoring plants with particular defenses. This study assesses the physical and chemical defenses mechanisms against herbivores of vegetative and reproductive organs. Its analyses of 12 species of Fabaceae (Leguminosae collected in remnants of Brazilian Chaco shows that 75% present structural defense characters and 50% have chemical defensedefense proteins in their seeds, like protease inhibitors and lectins. Physical defenses occur mainly on branches (78% of the species, leaves (67%, and reproductive organs (56%. The most common physical characters are trichomes and thorns, whose color represents a cryptic character since it does not contrast with the other plant structures. Defense proteins occur in different concentrations and molecular weight classes in the seeds of most species. Protease inhibitors are reported for the first time in seeds of: Albizia niopoides, Anadenanthera colubrina, Mimosa glutinosa, Prosopis rubriflora, and Poincianella pluviosa. The occurrence of physical and chemical defenses in members of Fabaceae indicate no associations between defense characters in these plant species of the Chaco.

  16. Macroevolutionary patterns of glucosinolate defense and tests of defense-escalation and resource availability hypotheses.

    Science.gov (United States)

    Cacho, N Ivalú; Kliebenstein, Daniel J; Strauss, Sharon Y

    2015-11-01

    We explored macroevolutionary patterns of plant chemical defense in Streptanthus (Brassicaceae), tested for evolutionary escalation of defense, as predicted by Ehrlich and Raven's plant-herbivore coevolutionary arms-race hypothesis, and tested whether species inhabiting low-resource or harsh environments invest more in defense, as predicted by the resource availability hypothesis (RAH). We conducted phylogenetically explicit analyses using glucosinolate profiles, soil nutrient analyses, and microhabitat bareness estimates across 30 species of Streptanthus inhabiting varied environments and soils. We found weak to moderate phylogenetic signal in glucosinolate classes and no signal in total glucosinolate production; a trend toward evolutionary de-escalation in the numbers and diversity of glucosinolates, accompanied by an evolutionary increase in the proportion of aliphatic glucosinolates; some support for the RAH relative to soil macronutrients, but not relative to serpentine soil use; and that the number of glucosinolates increases with microhabitat bareness, which is associated with increased herbivory and drought. Weak phylogenetic signal in chemical defense has been observed in other plant systems. A more holistic approach incorporating other forms of defense might be necessary to confidently reject escalation of defense. That defense increases with microhabitat bareness supports the hypothesis that habitat bareness is an underappreciated selective force on plants in harsh environments.

  17. Survey of Laboratories and Implementation of the Federal Defense Laboratory Diversification Program. Annex A. Department of the Army Domestic Technology Transfer

    Science.gov (United States)

    1993-11-01

    benefits provided by ARL’s substantial investment in marketing tools and displays which have been developed for use by the DTI" program as well as other ARL...conference. Other marketing tools range from tri-fold single page hand outs, up to 20 to 30 page full color brochures. The ARL DTT program is...this year several new marketing tools have been developed: a) An ARL DTr handout which provides a brief description of ARL, the DTT program technology

  18. The electro-chemical tests and the programmable autonomous potentiometer; Las pruebas electroquimicas y el potenciostato autonomo programable

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Ochoa, Esteban Miguel; Salazar Cruz, Sergio R.; Aguilar Soto, Armando; Ley Koo, Marcos [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1997-12-31

    The development of a programmable autonomous potentiostat is described as an instrumentation means for voltage and current measurement, considering that one of the main problems to solve is the metallic components corrosion. Also the electro-chemical tests that can be performed with this instrument are described, as well as some possible application [Espanol] Se describe el desarrollo de un potenciostato autonomo programable como medio de instrumentacion para medir voltajes y corrientes, tomando en cuenta que uno de los principales problemas por resolver es la corrosion de sus componentes metalicos. Se describen ademas las pruebas eletcroquimicas que pueden realizarse con este instrumento, asi como alguna posible aplicacion

  19. Moving Target Defense

    CERN Document Server

    Jajodia, Sushil; Swarup, Vipin; Wang, Cliff; Wang, X Sean

    2011-01-01

    Moving Target Defense: Creating Asymmetric Uncertainty for Cyber Threats was developed by a group of leading researchers. It describes the fundamental challenges facing the research community and identifies new promising solution paths. Moving Target Defense which is motivated by the asymmetric costs borne by cyber defenders takes an advantage afforded to attackers and reverses it to advantage defenders. Moving Target Defense is enabled by technical trends in recent years, including virtualization and workload migration on commodity systems, widespread and redundant network connectivity, instr

  20. Serious Games: Defense Advanced Research Projects Agency: An Interview with Innovation Information Office Program Manager CAPT Russell Shilling, PhD.

    Science.gov (United States)

    2012-04-01

    Dr. Shilling received his Doctor of Philosophy in Experimental Psychology (Auditory Psychophysics/Neuroscience) from the University of North Carolina at Greensboro in 1992 and his Bachelor of Arts in Psychology at Wake Forest University in 1985. In 1993 he graduated with top honors from Aerospace Experimental Psychologist training-Naval Flight Surgeon Class 93002. In 1996, he served as an Assistant/Associate Professor at the U.S. Air Force Academy in the Department of Behavioral Sciences and Leadership. In 2000, he arrived at the Naval Postgraduate School as an Associate Professor in the Operations Research and Systems Engineering Departments and became Technical Director for Immersive Technologies in the Modeling, Virtual Environments, and Simulation Institute. His military decorations include the Defense Superior Service Medal, Meritorious Service Medal (three awards), the Navy Commendation Medal, and the Navy Achievement Medal. He is also the recipient of the American Hospital Association's 2009 Executive Award for Excellence.

  1. Dynamic defense workshop :

    Energy Technology Data Exchange (ETDEWEB)

    Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.; Helinski, Ryan; Lamb, Christopher C.

    2013-02-01

    On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-art work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.

  2. Silicon-inducible defenses of Zinnia elegans against Myzus persicae

    Science.gov (United States)

    Several examples exist of silicon (Si) amendment inducing plant chemical defenses against plant pathogens, but few studies have focused on Si-induced defenses against phloem-feeding herbivores. The current study examined Si treatment of Zinnia elegans Jacq. cv. Oklahoma White (Compositae) on the pe...

  3. Use of physical/chemical mutagens in plant breeding program in Vietnam

    Energy Technology Data Exchange (ETDEWEB)

    Tran Duy Quy; Nguyen Huu Dong; Bui Huy Thuy; Le Van Nha; Nguyen Van Bich [Agricultural Genetics Institute, Hanoi (Viet Nam)

    2001-03-01

    Among more than 1870 new plant varieties formed by mutation breeding in the world, 44 varieties of different plants were formed by Vietnamese scientists. Research on induced mutation in Vietnam started in 1966, was promoted in Agricultural Institute, Cuu Long Delta Rice Research Institute, Institute of Food Crop Research, and Agriculture Universities, and has produced varieties of rice, maize, soybean, peanut, tomato, jujuba, green bean etc using physical and chemical mutagens: Irradiation with gamma rays or neutrons, and use of such chemicals as dimethylsulfate (DMS), diethylsulfate (DES), ethyleneimine (EI), N-nitrosomethylurea (NUM), N-nitrosoethylurea (NEU), and sodium azide (NaN{sub 3}). In the present report, the results of cytological and genetic effects in M1 plants, the frequency and spectrum of chlorophyll and morphological mutants, the mutants obtained and the genetic nature of the next generation are described, particularly for the case of rice. Radiation dose and dose rate used as mutagens are also reported. (S. Ohno)

  4. Equilibrium chemical reaction of supersonic hydrogen-air jets (the ALMA computer program)

    Science.gov (United States)

    Elghobashi, S.

    1977-01-01

    The ALMA (axi-symmetrical lateral momentum analyzer) program is concerned with the computation of two dimensional coaxial jets with large lateral pressure gradients. The jets may be free or confined, laminar or turbulent, reacting or non-reacting. Reaction chemistry is equilibrium.

  5. Analysis of Defense Products Contract Trends, 1990-2014

    Science.gov (United States)

    2015-04-30

    Analysis of Defense Products Contract Trends , 1990–2014 Andrew Hunter—is a senior fellow in the International Security Program and director of the Defense...a decade, the Defense-Industrial Initiatives Group at the Center for Strategic and International Studies (CSIS) has analyzed and reported on trends ...countervailing trend of divestments, including Northrop Grumman’s divestment of its shipbuilding business into Huntington Ingalls Industries. As

  6. The chemical industry in the Eureka program; La industria quimica dentro del programa Eureka

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Camus, J.M. [Ministerio de Industria y Energia. Madrid (Spain)

    1998-07-01

    Worldwide markets within the chemical industry imply the internationalization of the Spanish technology. In this sense, EUREKA is a necessary tool for the promotion of the R+D cooperative in Europe. The aim is to improve the future global competitiveness and employment capacity of European enterprises and to contribute to the future prosperity of European economies. Its guiding principle is that enterprises can best identify the project which will achieve this end. Through its network, the initiative promotes and facilitates the generation of high quality collaborative projects incorporating advanced technologies that correspond to market demands. (Author)

  7. Defense Mechanisms: A Bibliography.

    Science.gov (United States)

    Pedrini, D. T.; Pedrini, Bonnie C.

    This bibliography includes studies of defense mechanisms, in general, and studies of multiple mechanisms. Defense mechanisms, briefly and simply defined, are the unconscious ego defendants against unpleasure, threat, or anxiety. Sigmund Freud deserves the clinical credit for studying many mechanisms and introducing them in professional literature.…

  8. Avian host defense peptides

    NARCIS (Netherlands)

    Cuperus, Tryntsje; Coorens, M.; van Dijk, A.; Haagsman, H.P.

    2013-01-01

    Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense

  9. Unfolding Green Defense

    DEFF Research Database (Denmark)

    Larsen, Kristian Knus

    2015-01-01

    consumption in military operations, defense expenditure, energy security, and global climate change. The report then proceeds to introduce the NATO Green Defence Framework before exploring specific current uses of green technologies and green strategies for defense. The report concludes that a number...

  10. April 25, 2003, FY2003 Progress Summary and FY2002 Program Plan, Statement of Work and Deliverables for Development of High Average Power Diode-Pumped Solid State Lasers,and Complementary Technologies, for Applications in Energy and Defense

    Energy Technology Data Exchange (ETDEWEB)

    Meier, W; Bibeau, C

    2005-10-25

    The High Average Power Laser Program (HAPL) is a multi-institutional, synergistic effort to develop inertial fusion energy (IFE). This program is building a physics and technology base to complement the laser-fusion science being pursued by DOE Defense programs in support of Stockpile Stewardship. The primary institutions responsible for overseeing and coordinating the research activities are the Naval Research Laboratory (NRL) and Lawrence Livermore National Laboratory (LLNL). The current LLNL proposal is a companion document to the one submitted by NRL, for which the driver development element is focused on the krypton fluoride excimer laser option. The NRL and LLNL proposals also jointly pursue complementary activities with the associated rep-rated laser technologies relating to target fabrication, target injection, final optics, fusion chamber, target physics, materials and power plant economics. This proposal requests continued funding in FY03 to support LLNL in its program to build a 1 kW, 100 J, diode-pumped, crystalline laser, as well as research into high gain fusion target design, fusion chamber issues, and survivability of the final optic element. These technologies are crucial to the feasibility of inertial fusion energy power plants and also have relevance in rep-rated stewardship experiments. The HAPL Program pursues technologies needed for laser-driven IFE. System level considerations indicate that a rep-rated laser technology will be needed, operating at 5-10 Hz. Since a total energy of {approx}2 MJ will ultimately be required to achieve suitable target gain with direct drive targets, the architecture must be scaleable. The Mercury Laser is intended to offer such an architecture. Mercury is a solid state laser that incorporates diodes, crystals and gas cooling technologies.

  11. Defense Industry Clusters in Turkey

    Directory of Open Access Journals (Sweden)

    Kadir Alpaslan Demir

    2016-06-01

    Full Text Available All countries strive for a capable national defense supported by a strong national defense industry. Supporting national defense with imported defense systems has many limitations and risks because the terms of arms trade agreements between countries may easily be influenced by the political climate of the signatories. As a result, establishing an independent national defense requires a strong national defense industry. Furthermore, exporting defense systems may be an important source of national income. National defense industries mostly consist of large-scale defense firms that have the resources required for big defense contracts. However, small to medium enterprises (SMEs do not have the necessary resources, therefore they are at a disadvantage. To overcome this handicap and be part of the business, defense industry clusters mostly consisting of SMEs are being established. Provided that there is good national planning and support in this area, defense clusters consisting of SMEs may play a significant role in industry. SMEs have a chance to offer specialized services, special or customized products when needed. As a result, large defense firms subcontract certain portions of defense projects to SMEs. Since 2010, Turkey has shown signs of continuous improvement in defense industry clustering. In parallel with these developments, this study discusses the importance of clustering in the defense industry, briefly presents the state of the Turkish defense industry as highlighted by national statistics, and presents the current status of defense clusters in Turkey. The novelty of this article consists in its assessment of Turkish defense clusters.

  12. Integrated Baseline System (IBS), Version 1.03. User guide: Chemical Stockpile Emergency Preparedness Program

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, B.M.; Burford, M.J.; Downing, T.R.; Matsumoto, S.W.; Schrank, E.E.; Williams, J.R.; Winters, C.

    1993-01-01

    The Integrated Baseline System (IBS), operated by the Federal Emergency Management Agency (FEMA), is a system of computerized tools for emergency planing and analysis. This document is the user guide for the IBS and explains how to operate the IBS system. The fundamental function of the IBS is to provide tools that civilian emergency management personnel can use in developing emergency plans and in supporting emergency management activities to cope with a chemical-releasing event at a military chemical stockpile. Emergency management planners can evaluate concepts and ideas using the IBS system. The results of that experience can then be factored into refining requirements and plans. This document provides information for the general system user, and is the primary reference for the system features of the IBS. It is designed for persons who are familiar with general emergency management concepts, operations, and vocabulary. Although the IBS manual set covers basic and advanced operations, it is not a complete reference document set. Emergency situation modeling software in the IBS is supported by additional technical documents. Some of the other LBS software is commercial software for which more complete documentation is available. The IBS manuals reference such documentation where necessary. IBS is a dynamic system. Its capabilities are in a state of continuing expansion and enhancement.

  13. Integrated Baseline System (IBS), Version 1. 03. [Chemical Stockpile Emergency Preparedness Program

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, B.M.; Burford, M.J.; Downing, T.R.; Matsumoto, S.W.; Schrank, E.E.; Williams, J.R.; Winters, C.

    1993-01-01

    The Integrated Baseline System (IBS), operated by the Federal Emergency Management Agency (FEMA), is a system of computerized tools for emergency planing and analysis. This document is the user guide for the IBS and explains how to operate the IBS system. The fundamental function of the IBS is to provide tools that civilian emergency management personnel can use in developing emergency plans and in supporting emergency management activities to cope with a chemical-releasing event at a military chemical stockpile. Emergency management planners can evaluate concepts and ideas using the IBS system. The results of that experience can then be factored into refining requirements and plans. This document provides information for the general system user, and is the primary reference for the system features of the IBS. It is designed for persons who are familiar with general emergency management concepts, operations, and vocabulary. Although the IBS manual set covers basic and advanced operations, it is not a complete reference document set. Emergency situation modeling software in the IBS is supported by additional technical documents. Some of the other LBS software is commercial software for which more complete documentation is available. The IBS manuals reference such documentation where necessary. IBS is a dynamic system. Its capabilities are in a state of continuing expansion and enhancement.

  14. Report of the Defense Science Board Task Force on Defense Science and Technology Base for the 21st Century

    Science.gov (United States)

    2016-06-07

    Reference directed that the Task Force make recommendations on these issues: - The proper funding level for the Science and Technology program - The...REPORT OF THE DEFENSE SCIENCE BOARD TASK FORCE ON DEFENSE SCIENCE AND TECHNOLOGY BASE FOR THE 21ST CENTURY June 1998 OFFICE OF THE UNDER...number. 1. REPORT DATE 30 JUN 1998 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Report of the Defense Science Board Task

  15. A review of human biomonitoring data used in regulatory risk assessment under Canada's Chemicals Management Program.

    Science.gov (United States)

    Zidek, Angelika; Macey, Kristin; MacKinnon, Leona; Patel, Mikin; Poddalgoda, Devika; Zhang, Yi

    2016-10-21

    As a part of the Chemicals Management Plan launched in 2006, the Government of Canada is assessing and managing, where appropriate, the potential health and ecological risks associated with approximately 4300 substances under the Canadian Environmental Protection Act (1999). Since that time, nearly 3000 substances have been assessed, with human biomonitoring (HBM) data playing an increasingly important role for some substances. Case studies are presented, including both inorganic and organic substances (i.e., selenium, triclosan, phthalates), which highlight the impact and overall role HBM has had in regulatory decision making in Canada for these three substances as well as criteria used in the application of HBM data in human health risk assessment. An overview of its limitations in terms of how and when HBM data can be applied, when assessing human health in a regulatory setting, is discussed as well as the role HBM data can play in priority setting.

  16. XCHEM-1D: A Heat Transfer/Chemical Kinetics Computer Program for multilayered reactive materials

    Energy Technology Data Exchange (ETDEWEB)

    Gross, R.J.; Baer, M.R.; Hobbs, M.L.

    1993-10-01

    An eXplosive CHEMical kinetics code, XCHEM, has been developed to solve the reactive diffusion equations associated with thermal ignition of energetic materials. This method-of-lines code uses stiff numerical methods and adaptive meshing to resolve relevant combustion physics. Solution accuracy is maintained between multilayered materials consisting of blends of reactive components and/or inert materials. Phase change and variable properties are included in one-dimensional slab, cylindrical and spherical geometries. Temperature-dependent thermal properties have been incorporated and the modification of thermal conductivities to include decomposition effects are estimated using solid/gas volume fractions determined by species fractions. Gas transport properties, including high pressure corrections, have also been included. Time varying temperature, heat flux, convective and thermal radiation boundary conditions, and layer to layer contact resistances have also been implemented.

  17. Chemical milling of Zircaloy tubing to produce integral OD spiral finned tubes (AWBA development program)

    Energy Technology Data Exchange (ETDEWEB)

    Horwood, W.A.

    1982-02-01

    A detailed process description is provided for producing integral spiral fins on the outside surface of Zircaloy nuclear fuel cladding tubes by masking with pressure sensitive tape strips and then chemical milling (pickling) the tube wall between the tape strips to leave the fins in relief. Fins up to 0.020 inch high by 0.05 to 0.12 inch wide were consistently produced on tubes having wall thickness of 0.008 inch or greater after fin pickling. Wall thickness uniformity was excellent. Information is provided on tube surface preparation to maximize tape mask adhesion time during pickling, acid chemistry control to prevent local tube wall thinning near the fin, and pickling techniques to promote uniform material removal. Simple fixture designs are described for quickly and conveniently applying the tape strips to the tube wall in an accurate spiral. 13 figures, 4 tables.

  18. Public-Private Partnerships in Defense Acquisition Programs-Defensible?

    Science.gov (United States)

    2009-12-01

    Rescue Vehicle STS Simulation, Training and Support (a division of Lockheed Martin) TCA transaction cost analysis U.S. United States UK United...theory of Transaction Cost Analysis (TCA). In the context of PPPs, transaction costs are the costs of arranging for the contracts and enforcing them...by firms, and when they would be performed by the market. ( Transaction Cost , n.d.), wilkipedia.org). The underlying concepts of TCA are (i) the two

  19. PACKAGE (Plasma Analysis, Chemical Kinetics and Generator Efficiency): a computer program for the calculation of partial chemical equilibrium/partial chemical rate controlled composition of multiphased mixtures under one dimensional steady flow

    Energy Technology Data Exchange (ETDEWEB)

    Yousefian, V.; Weinberg, M.H.; Haimes, R.

    1980-02-01

    The NASA CEC Code was the starting point for PACKAGE, whose function is to evaluate the composition of a multiphase combustion product mixture under the following chemical conditions: (1) total equilibrium with pure condensed species; (2) total equilibrium with ideal liquid solution; (3) partial equilibrium/partial finite rate chemistry; and (4) fully finite rate chemistry. The last three conditions were developed to treat the evolution of complex mixtures such as coal combustion products. The thermodynamic variable pairs considered are either pressure (P) and enthalpy, P and entropy, at P and temperature. Minimization of Gibbs free energy is used. This report gives detailed discussions of formulation and input/output information used in the code. Sample problems are given. The code development, description, and current programming constraints are discussed. (DLC)

  20. Transition-ready technologies and expertise from the Chemical and Biological National Security Program at LLNL

    Energy Technology Data Exchange (ETDEWEB)

    Folta, P A; McBride, M T

    2006-02-22

    HSARPA has initiated a new Bioinformatics and Assay Development solicitation, BIAD2 (BAA 06-01), to address a number of technology gaps and requirements for biodetection (www.hsarpabaa.com). This solicitation will leverage the vast research and development capabilities of the private sector and academia in order to meet the needs of HSARPA and Homeland Security. In order to meet these requirements, this solicitation will: (1) Develop and validate actionable assays for the public and private sector; (2) Develop and validate new assays and novel assay methodologies to enhance existing detection systems and enable future detection platforms; (3) Develop next generation assays which are robust against novel, emerging and engineered threats; (4) Develop novel assays that detect low levels of ribonucleic acid (RNA)-based viral threats in complex backgrounds; (5) Develop novel assays to characterize the viability, degree of virulence or toxicity, and countermeasure resistance of a biological agent; and (6) Develop new bioinformatics tools to support assay development and assay validation The Lawrence Livermore National Laboratory (LLNL) Bioassays and Signature Program (BSP) develops nationally-validated detection and identification assays to cover the full range of biological threat agents, starting from human, animal, and plant pathogens on the Select Agent list. The assays that have been co-developed by the CDC and the BSP are used internationally and represent the gold standard for molecular detection of select agent pathogens for the public health community. They are also used in the DHS environmental monitoring operations such as BioWatch and DHS National Security Special Events support. These reagents have been used to process and analyze more than 5 million samples and have delivered exceptional performance for the end users, with zero false positives since their deployment. Currently, highly-multiplexed nucleic acid assays that represent the &apos

  1. Review of Four Years of Literature (1985, 1986, 1987 and 1988) for the Physiological and Psychological Effects of the Nuclear/Biological/Chemical and Extended Operations on Soldier Performance Program

    Science.gov (United States)

    1988-12-30

    REGENERATING BRAIN CHOLINESTEPASE. FIGURES AND BIBLIOGRAPHY ARE WORTHWHILE. THE DOCUMENT PROVIDES A GOOD SUMIMARY OF CURRENT KNOWLEDGE. TITLE: ANALYSIS OF...AIR BASE COMPUTER MODEL WAS USED TO SIMULATE AIR BASE OPERATIONS. TITLE: CHEMICAL DEFENSE PLANNING DOCUMENT ( COPD ), VOLUME V: APPENDICES ORIGINATING...I DEALT WITH REGENERATING FILTERS FOR CHEMICAL AGENT APPLICATIONS. IT WAS INITIALLY THOUGHT THAT VEHICLE ENGINE HIEAT WOULD PROVIDE THE DRIVING FORCE

  2. National Defense Budget Estimates for FY 2012

    Science.gov (United States)

    2011-03-01

    Military Construction, Navy Reserve 21,708 26,299 26,299 26,299 Military Construction, Air Force Reserve 25,986 33,620 33,620 33,620 Chemical Demil ...Air Force Reserve 7,634 Chemical Demil Construction, Defense 75,312 13,071,701 Appropriation 13,071,701 Budget Authority 13,071,701 TOA...7.00 3.00 Defense Prod Act 59.00 25.00 16.00 Chemical Demil 53.00 30.00 15.00 2.00 RDT&E Army 34.28 48.72 11.33 3.17 1.70 0.80 Navy 36.87 50.51 9.82

  3. Fifteenth symposium on biotechnology for fuels and chemicals: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    This collection contains 173 abstracts from presented papers and poster sessions. The five sessions of the conference were on the subjects of: (1) Thermal, Chemical, and Biological Processing, (2) Applied Biological Research, (3) Bioprocessing Research (4), Process Economics and Commercialization, and (5) Environmental Biotechnology. Examples of specific topics in the first session include the kinetics of ripening cheese, microbial liquefaction of lignite, and wheat as a feedstock for fuel ethanol. Typical topics in the second session were synergism studies of bacterial and fungal celluloses, conversion of inulin from jerusalem artichokes to sorbitol and ethanol by saccharomyces cerevisiae, and microbial conversion of high rank coals to methane. The third session entertained topics such as hydrodynamic modeling of a liquid fluidized bed bioreactor for coal biosolubilization, aqueous biphasic systems for biological particle partitioning, and arabinose utilization by xylose-fermenting yeast and fungi. The fourth session included such topics as silage processing of forage biomass to alcohol fuels, economics of molasses to ethanol in India, and production of lactic acid from renewable resources. the final session contained papers on such subjects as bioluminescent detection of contaminants in soils, characterization of petroleum contaminated soils in coral atolls in the south Pacific, and landfill management for methane generation and emission control.

  4. Chemical Stockpile Disposal Program: Review and comment on the Phase 1 environmental report for the Pueblo Depot Activity, Pueblo, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    Olshansky, S.J.; Krummel, J.R.; Policastro, A.J.; McGinnis, L.D.

    1994-03-01

    As part of the Chemical Stockpile Disposal Program, an independent review is presented of the US Army Phase I environmental report for the disposal of chemical agents and munitions stored at the Pueblo Depot Activity (PUDA) in Pueblo, Colorado. The Phase I report addresses new and additional concerns not incorporated in the final programmatic environmental impact statement (FPEIS). These concerns are addressed by examining site-specific data for the PUDA. On the basis of our review of the Phase I report, we concluded that on-site meteorological data from December 1988 to June 1992 appear to be of insufficient quality to have been used instead of the off-site Pueblo airport data. No additional meteorological data have been collected since June 1992. The Phase I report briefly mentions problems with the air pollution control system. These problems will likely require the systems to be upgraded at the Johnston Atoll site and at each of the other depots in the continental United States. Without such improvements, the probability of accidents during start-up and shutdown would likely increase. The Army has a lessons-learned program to incorporate improvements into the design of future facilities. The Phase I report does not make any design change commitments. These issues need to be fully evaluated and resolved before any final conclusion concerning the adequacy of the decision in the FPEIS can be made with respect to the PUDA. With the exception of this issue, the inclusion of other more detailed site-specific data in the Phase I report does not change the decision reached in the FPEIS (which favored on-site disposal at the PUDA). We recommend that site-specific data on water, ecological, socioeconomic, and cultural resources and emergency planning and preparedness be considered explicitly in the site-specific EIS decision-making process.

  5. Evaluation of chemical data from selected sites in the Surface-Water Ambient Monitoring Program (SWAMP) in Florida

    Science.gov (United States)

    Katz, B.G.; Collins, J.J.

    1998-01-01

    A cooperative study between the Florida Department of Environmental Protection (FDEP) and the U.S. Geological Survey was conducted to assess the integrity of selected water-quality data collected at 150 sites in the FDEP Surface-Water Ambient Monitoring Program (SWAMP) in Florida. The assessment included determining the consistency of the water-quality data collected statewide, including commonality of monitoring procedures and analytes, screening of the gross validity of a chemical analysis, and quality assurance and quality control (QA/QC) procedures. Four tests were used to screen data at selected SWAMP sites to estimate the gross validity of selected chemical data: (1) the ratio of dissolved solids (in milligrams per liter) to specific conductance (in microsiemens per centimeter); (2) the ratio of total cations (in milliequivalents per liter) multiplied by 100 to specific conductance (in microsiemens per centimeter); (3) the ratio of total anions (in milliequivalents per liter) multiplied by 100 to specific conductance (in microsiemens per centimeter); and (4) the ionic charge-balance error. Although the results of the four screening tests indicate that the chemical data generally are quite reliable, the extremely small number of samples (less than 5 percent of the total number of samples) with sufficient chemical information to run the tests may not provide a representative indication of the analytical accuracy of all laboratories in the program. In addition to the four screening tests, unusually low or high values were flagged for field and laboratory pH (less than 4.0 and greater than 9.0) and specific conductance (less than 10 and greater than 10,000 microsiemens per centimeter). The numbers of flagged data were less than 1 percent of the 19,937 water samples with pH values and less than 0.6 percent of the 16,553 water samples with specific conductance values. Thirty-four agencies responded to a detailed questionnaire that was sent to more than 60 agencies

  6. Implementation plan for the Defense Nuclear Facilities Safety Board Recommendation 90-7. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Borsheim, G.L.; Cash, R.J.; Dukelow, G.T.

    1992-12-01

    This document revises the original plan submitted in March 1991 for implementing the recommendations made by the Defense Nuclear Facilities Safety Board in their Recommendation 90-7 to the US Department of Energy. Recommendation 90-7 addresses safety issues of concern for 24 single-shell, high-level radioactive waste tanks containing ferrocyanide compounds at the Hanford Site. The waste in these tanks is a potential safety concern because, under certain conditions involving elevated temperatures and low concentrations of nonparticipating diluents, ferrocyanide compounds in the presence of oxidizing materials can undergo a runaway (propagating) chemical reaction. This document describes those activities underway by the Hanford Site contractor responsible for waste tank safety that address each of the six parts of Defense Nuclear Facilities Safety Board Recommendation 90-7. This document also identifies the progress made on these activities since the beginning of the ferrocyanide safety program in September 1990. Revised schedules for planned activities are also included.

  7. Defense Small Business Innovation Research Program (SBIR). Volume 2. Navy Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

    Science.gov (United States)

    1990-04-01

    FOUND, FROM EXPERIENCE GAINED ON THE CRITICAL SEA TEST ( CZT ) AND THE LOW FREQUENCY ACOUSTICS (LFA) PROGRAMS, THAT THE ACOUSTIC ENVIRONMENT FOR LONG RANGE...CUSTOM "ROUTING- ASIC , THE IMAGINATION WORKS PROPOSLS A NEW AND INNOVATIVE SOLUTION TO THE HARDWARE/SOFTWARE BOUNDARY PROBLEM, ENABLING A COPROCESSOR TO...AND VLSI CHIPS, INCLUDING VHSIC AND ASIC . THE NUMBER OF WORK STATIONS, COMPUTERS, SOFTWARE PACKAGES, DATA FORMATS, FILE TRANSFER STANDARDS, PLOTTER

  8. Defense Small Business Innovation Research Program (SBIR). Volume 3. Air Force Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

    Science.gov (United States)

    1990-04-01

    ALEXANDRIA, VA 22311 CONTRACT NUMBER: F19628-89-C-0127 B J STRALSER TITLE: SPECIAL OPERATIONS COMMUNICATIONS SYSTEM ( SPOCS ) TOPIC# 31 OFFICE: ESD/AVP IDENT...THAT THERE MAY BE A SINGLE SOLUTION TO FULFILLING THOSE CRITICAL REQUIREMENTS. THE SPECIAL OPERATIONS COMMUNICATION SYSTEM ( SPOCS ), USES A PULSE STREAM...PROGRAM - PHASE 1 PAGE 344 BY SERVICE FISCAL YEAR 1989 AF SUBMITTED BY THIS PROPOSAL DESCRIBES THE STEPS NECESSARY TO DEVELOP AN ONLINE GAS

  9. Rethinking Defensive Information Warfare

    Science.gov (United States)

    2004-06-01

    electronic warfare, and special information operations. Defensive information operations ensure timely, accurate, and relevant information access...information and information systems. IA, physical security, OPSEC, counter-deception, counter-psyops, CI, EW, and special information operations. Ensure

  10. Surfing China's National Defense

    Institute of Scientific and Technical Information of China (English)

    Ji Guilin

    2010-01-01

    @@ Following the start of its first test run on August 20, 2009, the website www.mod.gov.cn of the Ministry of National Defense (MOD) of the People's Republic of China has logged more than 2 billion hits,from many countries and regions including China, the United States,the United Kingdom, Japan, Australia and Singapore. China National Defense News reporters recently interviewed Ji Guilin, the website's Editor in Chief, on its performance and the feedback of netizens.

  11. 76 FR 28757 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-05-18

    ... of the Secretary Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Notice of Availability (NOA) of Revised Defense Logistics Agency Regulation. SUMMARY: The Defense...

  12. 75 FR 76423 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

    Science.gov (United States)

    2010-12-08

    ... of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of... a closed meeting of the Defense Intelligence Agency National Defense Intelligence College Board...

  13. 76 FR 28960 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

    Science.gov (United States)

    2011-05-19

    ... of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of... a closed meeting of the Defense Intelligence Agency National Defense Intelligence College Board...

  14. Chemical Engineering Division fuel cycle programs. Quarterly progress report, July-September 1978

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M.J.; Ader, M.; Barletta, R.E.

    1980-01-01

    Fuel cycle work included hydraulic performance and extraction efficiency of eight-stage centrifugal contactors, flowsheet for the Aralex process, Ru and Zr extraction in a miniature centrifugal contactor, study of Zr aging in the organic phase and its effect on Zr extraction and hydraulic testing of the 9-cm-ID contactor. Work for predicting accident consequences in LWR fuel processing covered the relation between energy input (to subdivide a solid) and the modes of particle size frequency distribution. In the pyrochemical and dry processing program corrosion-testing materials for containment vessels and equipment for studying carbide reactions in bismuth is under way. Analytical studies have been made of salt-transport processes; efforts to spin tungsten crucibles 13 cm dia continue, and other information on tungsten fabrication is being assembled; the process steps of the chloride volatility process have been demonstrated and the thoria powder product used to produce oxide pellets; solubility of UO/sub 2/, PuO/sub 2/, and fission products in molten alkali nitrates is being investigated; work was continued on reprocessing actinide oxides by extracting the actinides into ammonium chloroaluminate from bismuth; the preparation of thorium-uranium carbide from the oxide is being studied as a means of improving the oxide reactivity; studies are in progress on producing uranium metal and decontaminated ThO/sub 2/ by the reaction of (Th,U)O/sub 2/ solid solution in molten salts containing ThCl/sub 4/ and thorium metal chips. In the molten tin process, no basic thermodynamic or kinetic factors have been found that may limit process development.

  15. Low Level Chemical Toxicity: Relevance to Chemical Agent Defense

    Science.gov (United States)

    2005-07-01

    at national meetings, publications and awards. It has also led to the submission of new grant application and the receipt of an NIH supplement to...restraint stress in OTKO mice (Nomura et al. 2003). These studies using OT supplementation and genetic deficiency indicate that OT may inhibit the...Effect of acetyl-l- carnitine on hyperactivity and spatial memory deficits of rats exposed to neonatal anoxia. Neurosci Lett 1997;223:201–5. Ellman GL

  16. Chemical Engineering Division Fuel Cycle Programs. Quarterly progress report, January-March 1979

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M J; Ader, M; Barletta, R E

    1980-01-01

    In the program on pyrochemical and dry processing methods (PDPM) for nuclear fuel, corrosion testing of refractory metals and alloys, graphite, and SiC in PDPM environments was done. A tungsten-metallized Al/sub 2/O/sub 3/-3% Y/sub 2/O/sub 3/ crucible was successfully fabricated. Tungsten microstructure of a plasma-sprayed tungsten crucible was stabilized by nickel infiltration and heat treatment. Solubility measurements of Th in Cd and Cd-Mg alloys were continued, as were experiments to study the reduction of high-fired ThO/sub 2/. Work on the fused salt electrolysis of CaO also was continued. The method of coprocessing of U and Pu by a salt transport process was modified. Tungsten-coated molybdenum crucibles were fabricated. The proliferation resistance of chloride volatility processing of thorium-based fuels is being evaluated by studying the behavior of fission product elements during chlorination of U and Th. Thermodynamic analysis of the phase relationships in the U-Pu-Zn system was initiated. The Pyro-Civex reprocessing method is being reviewed. Reactivity of UO/sub 2/ and PuO/sub 2/ with molten equimolar NaNO/sub 3/-KNO/sub 3/ is being studied along with the behavior of selected fission product elements. Work was continued on the reprocessing of actinide oxides by extracting the actinides from a bismuth solution. Rate of dissolution of UO/sub 2/ microspheres in LiCl/AlCl/sub 3/ was measured. Nitriding rates of Th and U dissolved in molten tin were measured. In work on the encapsulation of radioactive waste in metal, leach rates of a simulated waste glass were studied. Rates of dissolution of metals (potential barrier materials) in aqueous media are being studied. In work on the transport properties of nuclear waste in geologic media, the adsorption of iodate by hematite as a function of pH and iodate concentration was measured. The migration behavior of cesium in limestone was studied in relation to the cesium concentration and pH of simulated groundwater

  17. Technology Commercialization Program 1991

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This reference compilation describes the Technology Commercialization Program of the Department of Energy, Defense Programs. The compilation consists of two sections. Section 1, Plans and Procedures, describes the plans and procedures of the Defense Programs Technology Commercialization Program. The second section, Legislation and Policy, identifies legislation and policy related to the Program. The procedures for implementing statutory and regulatory requirements are evolving with time. This document will be periodically updated to reflect changes and new material.

  18. 32 CFR 555.8 - Program documentation.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Program documentation. 555.8 Section 555.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND... TESTS, WORK FOR OTHERS § 555.8 Program documentation. Program documentation will be submitted...

  19. Complete (1)H and (13)C NMR chemical shift assignments of mono-, di-, and trisaccharides as basis for NMR chemical shift predictions of polysaccharides using the computer program casper.

    Science.gov (United States)

    Roslund, Mattias U; Säwén, Elin; Landström, Jens; Rönnols, Jerk; Jonsson, K Hanna M; Lundborg, Magnus; Svensson, Mona V; Widmalm, Göran

    2011-08-16

    The computer program casper uses (1)H and (13)C NMR chemical shift data of mono- to trisaccharides for the prediction of chemical shifts of oligo- and polysaccharides. In order to improve the quality of these predictions the (1)H and (13)C, as well as (31)P when applicable, NMR chemical shifts of 30 mono-, di-, and trisaccharides were assigned. The reducing sugars gave two distinct sets of NMR resonances due to the α- and β-anomeric forms. In total 35 (1)H and (13)C NMR chemical shift data sets were obtained from the oligosaccharides. One- and two-dimensional NMR experiments were used for the chemical shift assignments and special techniques were employed in some cases such as 2D (1)H,(13)C-HSQC Hadamard Transform methodology which was acquired approximately 45 times faster than a regular t(1) incremented (1)H,(13)C-HSQC experiment and a 1D (1)H,(1)H-CSSF-TOCSY experiment which was able to distinguish spin-systems in which the target protons were only 3.3Hz apart. The (1)H NMR chemical shifts were subsequently refined using total line-shape analysis with the PERCH NMR software. The acquired NMR data were then utilized in the casper program (http://www.casper.organ.su.se/casper/) for NMR chemical shift predictions of the O-antigen polysaccharides from Klebsiella O5, Shigella flexneri serotype X, and Salmonella arizonae O62. The data were compared to experimental data of the polysaccharides from the two former strains and the lipopolysaccharide of the latter strain showing excellent agreement between predicted and experimental (1)H and (13)C NMR chemical shifts.

  20. Key Technology R&D Program of Rubber Chemicals Industry in the "11th Five-year Plan" Passed National Acceptance

    Institute of Scientific and Technical Information of China (English)

    Yu Tao

    2012-01-01

    As a project under National Key Technology R&D Program in the "11th Five-year Plan", "Develop- ment of Rubber Chemicals Cleaning Technology and Special Functional Products" passed the acceptance of the Ministry of Science and Technology recently.

  1. E4CHEM. A simulation program for the fate of chemicals in the environment. Handbook. User`s guide and description. Version 3.6. December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Brueggemann, R. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Projektgruppe Umweltgefaehrdungspotentiale von Chemikalien; Drescher-Kaden, U. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Projektgruppe Umweltgefaehrdungspotentiale von Chemikalien; Muenzer, B. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Projektgruppe Umweltgefaehrdungspotentiale von Chemikalien

    1996-02-01

    The predominant aims of E4CHEM are: Deterministic description of the chemical`s behavior in the environment with varying ecoparameters including the special aspects; Behavior of the same chemical in different compartments; Behavior of different chemicals in the same compartment with the same ecoparameters; Tracing back of chemicals detected in the environment to the possible source by means of check procedures like in EXWAT, one of the E4CHEM models; Discharge of the user from extensive calculation operations; Interpretation of experimental results. In combination with statistics and algebraic tools (lattice theory) but not included in E4CHEM yet: Selection of descriptors as tool for priority setting; Identification and ranking of chemicals according to their risk to the environment by comparing descriptors within descriptor matrices about the behavior of chemicals deived from the different models. Furthermore: Identification of chemical applicable as reference substances with respect to environmental behavior. The program E4CHEM is described in this manual. (orig./SR)

  2. Defense styles of pedophilic offenders.

    Science.gov (United States)

    Drapeau, Martin; Beretta, Véronique; de Roten, Yves; Koerner, Annett; Despland, Jean-Nicolas

    2008-04-01

    This pilot study investigated the defense styles of pedophile sexual offenders. Interviews with 20 pedophiles and 20 controls were scored using the Defense Mechanisms Rating Scales. Results showed that pedophiles had a significantly lower overall defensive functioning score than the controls. Pedophiles used significantly fewer obsessional-level defenses but more major image-distorting and action-level defenses. Results also suggested differences in the prevalence of individual defenses where pedophiles used more dissociation, displacement, denial, autistic fantasy, splitting of object, projective identification, acting out, and passive aggressive behavior but less intellectualization and rationalization.

  3. Science and Technology for Bioterrorism Defense

    Energy Technology Data Exchange (ETDEWEB)

    Fitch, J P

    2004-05-04

    The Lawrence Livermore National Laboratory (LLNL) Chemical & Biological National Security Program (CBNP) provides science, technology, and integrated systems for chemical and biological security. Our approach is to develop and field systems that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons.

  4. Defensive use of an acquired substance (carminic acid) by predaceous insect larvae.

    Science.gov (United States)

    Eisner, T; Ziegler, R; McCormick, J L; Eisner, M; Hoebeke, E R; Meinwald, J

    1994-06-15

    Larvae of two insects, a coccinellid beetle (Hyperaspis trifurcata) and a chamaemyiid fly (Leucopis sp.), feed on cochineal insects and appropriate their prey's defensive chemical, carminic acid, for protective purposes of their own. H. trifurcata discharges the chemical with droplets of blood (hemolymph) that it emits when disturbed; Leucopis sp. ejects the compound with rectal fluid. Ants are thwarted by these defenses, which are compared with the previously-described defense of a pyralid caterpillar (Laetilia coccidivora) that disgorges carminic acid-laden crop fluid. The defensive fluid of all three larvae contains carminic acid at concentrations spanning a range (0.2-6.2%) proven deterrent to ants. Many insects are known to appropriate defensive substances from plants. Insects that acquire defensive chemicals from animal sources may be relatively rare.

  5. Inducible direct plant defense against insect herbivores: A review

    Institute of Scientific and Technical Information of China (English)

    Ming-Shun Chen

    2008-01-01

    Plants respond to insect herbivory with responses broadly known as direct defenses, indirect defenses, and tolerance. Direct defenses include all plant traits that affect susceptibility of host plants by themselves. Overall categories of direct plant defenses against insect herbivores include limiting food supply, reducing nutrient value, reducing preference, disrupting physical structures, and inhibiting chemical pathways of the attacking insect. Major known defense chemicals include plant secondary metabolites, protein inhibitors of insect digestive enzymes, proteases, lectins, amino acid deaminases and oxidases. Multiple factors with additive or even synergistic impact are usually involved in defense against a specific insect species, and factors of major importance to one insect species may only be of secondary importance or not effective at all against another insect species. Extensive qualitative and quantitative high throughput analyses of temporal and spatial variations in gene expression, protein level and activity, and metabolite concentration will accelerate not only the understanding of the overall mechanisms of direct defense, but also accelerate the identification of specific targets for enhancement of plant resistance for agriculture.

  6. Atomic Structure and Valence: Level II, Unit 10, Lesson 1; Chemical Bonding: Lesson 2; The Table of Elements: Lesson 3; Electrolysis: Lesson 4. Advanced General Education Program. A High School Self-Study Program.

    Science.gov (United States)

    Manpower Administration (DOL), Washington, DC. Job Corps.

    This self-study program for high-school level contains lessons on: Atomic Structure and Valence, Chemical Bonding, The Table of Elements, and Electrolysis. Each of the lessons concludes with a Mastery Test to be completed by the student. (DB)

  7. Defense Business Transformation

    Science.gov (United States)

    2009-12-01

    other. SCM and ERP systems both contribute to the overall distribution and coordination of resources. Just as an ERP enhances information flow...inventory management system (Thureen 2008). It combines the Army’s disparate wholesale and retail inventories, into one combined system (Sparacino 2002...Studies.............................................................................. 73 1. Defense Integrated Military Human Resource System

  8. Polyphenol Oxidase as a Biochemical Seed Defense Mechanism

    Directory of Open Access Journals (Sweden)

    E. Patrick Fuerst

    2014-12-01

    Full Text Available Seed dormancy and resistance to decay are fundamental survival strategies, which allow a population of seeds to germinate over long periods of time. Seeds have physical, chemical, and biological defense mechanisms that protect their food reserves from decay-inducing organisms and herbivores. Here, we hypothesize that seeds also possess enzyme-based biochemical defenses, based on induction of the plant defense enzyme, polyphenol oxidase (PPO, when wild oat (Avena fatua L. caryopses and seeds were challenged with seed-decaying Fusarium fungi. These studies suggest that dormant seeds are capable of mounting a defense response to pathogens. The pathogen-induced PPO activity from wild oat was attributed to a soluble isoform of the enzyme that appeared to result, at least in part, from proteolytic activation of a latent PPO isoform. PPO activity was also induced in wild oat hulls (lemma and palea, non-living tissues that cover and protect the caryopsis. These results are consistent with the hypothesis that seeds possess inducible enzyme-based biochemical defenses arrayed on the exterior of seeds and these defenses represent a fundamental mechanism of seed survival and longevity in the soil. Enzyme-based biochemical defenses may have broader implications since they may apply to other defense enzymes as well as to a diversity of plant species and ecosystems.

  9. The Combined Release and Radiation Effects Satellite (CRRES) program: A unique series of scientific experiments

    Science.gov (United States)

    Reasoner, David L.; McCook, Morgan W.; Vaughan, William W.

    The Defense Department and NASA have joined in a program to study the space environment which surrounds the earth and the effects of space radiation on modern satellite electronic systems. The Combined Release and Radiation Effects Satellite (CRRES) will carry an array of active experiments including chemical releases and a complement of sophisticated scientific instruments to accomplish these objectives. Other chemical release active experiments will be performed with sub-orbital rocket probes. The chemical releases will 'paint' the magnetic and electric fields of earthspace with clouds of glowing ions. Earthspace will be a laboratory, and the releases will be studied with an extensive network of ground-, aircraft-, and satellite-based diagnostic instruments. Some of the topics discussed include the following: the effects of earthspace; the need for active experiments; types of chemical releases; the CRRES program schedule; international support and coordinated studies; photographing chemical releases; information on locating chemical releases for observation by the amateur; and CRRES as a program.

  10. 76 FR 53119 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-08-25

    ... Office of the Secretary Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Comment Addressed on Notice of Availability (NOA) of Revised Defense Logistics Agency Regulation...

  11. Preliminary assessment of the aquatic impacts of a proposed defense waste processing facility at the Savannah River Plant

    Energy Technology Data Exchange (ETDEWEB)

    Mackey, H.E. Jr.

    1979-01-01

    A review of the literature indicates that a significant body of descriptive information exists concerning the aquatic ecology of Upper Three Runs Creek and Four Mile Creek of the Savannah River Plant south of Aiken, South Carolina. This information is adequate for preparation of an environmental document evaluating these streams. These streams will be impacted by construction and operation of a proposed Defense Waste Processing Facility for solidification of high level defense waste. Potential impacts include (1) construction runoff, erosion, and siltation, (2) effluents from a chemical and industrial waste treatment facility, and (3) radionuclide releases. In order to better evaluate potential impacts, recommend mitigation methods, and comply with NEPA requirements, additional quantitative biological information should be obtained through implementation of an aquatic baseline program.

  12. Avian host defense peptides.

    Science.gov (United States)

    Cuperus, Tryntsje; Coorens, Maarten; van Dijk, Albert; Haagsman, Henk P

    2013-11-01

    Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many organisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are not confined to direct antimicrobial actions. Research in mammals has indicated that HDPs have many immunomodulatory functions and are also involved in other physiological processes ranging from development to wound healing. During the past five years our knowledge about avian HDPs has increased considerably. This review addresses our current knowledge on the evolution, regulation and biological functions of HDPs of birds.

  13. Defense Logistics Agency’s Warstopper Program

    Science.gov (United States)

    2007-08-15

    Support ($11.7 million), and Construction and Equipment ($3.3 million) contracts. We did not examine Warstopper funding related to contracts for...protection barrier consisting of a prefabricated, multicellular system made of a welded steel-wire mesh, heavily galvanized, with a nonwoven geotextile...chamber. DLA decided to fund the construction of an additional Nesatron chamber with the option to sell it to the contractor at fair market value at

  14. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2014-03-01

    contributors to this report were J. Kristopher Keener, Assistant Director; Matthew T. Drerup; Jonathan Mulcare; Danny Owens; Charlie Shivers; and...MQ-1C Gray Eagle) Deanna Laufer, James S. Kim MQ-4C Triton Unmanned Aircraft System (MQ-4C Triton) Tom Twambly, Candice N. Wright, Amanda Parker MQ-8

  15. Benefits of the Defense Standardization Program

    Science.gov (United States)

    1991-09-01

    motor scooters , and bicycles 24GP Tractors 2410 Tractors, full-track, low-speed 2420 Tractors, wheeled 2430 Tractors, track-laying, high-speed 25GP... suspension and the self-deflating, and self-inflating capability of the Air Force tires when the vehicle switches from on-road to off-road and back...road to off-road and back again, and independent suspension . C-4 Using the purchase description, NAVFAC issued an invitation for bids and has awarded

  16. Future Years Defense Program (FYDP) Structure

    Science.gov (United States)

    2004-04-01

    Armored Cav Troops (Sep) 1297 RSTA Sqdn (Recon) (SBCT) Artillery Battalions/Sep Btry’s 1300 105MM (T) Artillery Battalions 1301 105MM Theather Field...1421 Engineer Team 1422 Engineer Companies (Separate) 1423 Engineer Combat Bn (Div) 1424 Engr Combat Bns (Corps) 1425 Engineer Brigade Theather ...Military Police Group 3074 Military Police Brigade 3075 Military Police Command, HHC 3080 Military History Detachment 3090 Legal, Support Team Surface to

  17. Defense Switched Network Technology and Experiments Program.

    Science.gov (United States)

    2014-09-26

    3) development and test of data communication techniques using DoD-standard data protocols in an integrated voice /data network, and (4) EISN system... communication techniques using DoD-standard data protocols in an integrated voice /data network, and (4) EISN system coordination and experiment planning...control voice trunks that use E&M signaling and go from the RCP switch to the PCI or to another RCP switch; (e) A Dual- Tone Multiple-Frequency (DTMF

  18. Defense Acquisition University Program Managers Tool Kit

    Science.gov (United States)

    2011-01-01

    22 Procurement Appropriations (Account Numbers and Budget Activities) ................ 23–24 Research, Dev ., Test, and Eval...BA 4 Adv. Comp. Dev . and Prototypes amount amount 6.5 BA 5 System Devel. and Demo. appropriated appropriated 6.6 BA 6 RDT&E Management Support...Testing with . . . (To Include the Mod Kits used for Testing) Is DT or IOT &E Required? Procurement $ YES RDT&E $ NO RDT&E Development Costs of PME

  19. Defense Standardization Program Status of Standardization Projects

    Science.gov (United States)

    1993-09-30

    PY TY SN YN SRR SRR SRR SRR T YT YT T RT SD 6230 1029 MIL-L-52240B ME LANTERN ELEC LIGHT SOUR GL 02 931 934 942 A GL SH 99 GS U 6230 N323 MIL L 16879C...GS N 7320 0903 A-A-XXX VEGETABLE PEELING MACHINE ELEC GL B4 A 931 934 934 A GL YDI 99 GS N 7320 0904 MIL-D-13053D NOT 1 DOUGH TROUGHS GL H5 932 941...934 G GL YDi 99 GS U 7320 0906 MIL-D-2471D DOUGH DIVIDING MACHINE GL H5 931 941 934 G GL YDV 99 GS U 7320 0907 MIL-B-43386B NOT 1 BIN INGRE MOBILE GL

  20. Defense Acquisitions. Assessments of Selected Weapon Programs

    Science.gov (United States)

    2007-03-01

    countermeasure dispenser capable of loading and employing expendables, such as flares, chaff, and smoke . S Page 39ource: BAE Systems.System development...not collecting statistical data for them. As reported in our last assesment , we expect that the prime contract could overrun its target cost by

  1. Defense Coastal/Estuarine Research Program (DCERP)

    Science.gov (United States)

    2007-09-19

    led by Joan Walker. Another management need is to be better able to use habitat off Base in recovery of RCWs, so that the birds on Base are better...7(2):358–380. Valiela, I., K. Foreman, M. LaMontagne, D. Hersh, J. Costa , P. Peckol, B. DeMeo-Andreson, C. D’Avanzo, M. Babione, C.-H. Sham, J...information from Regenerating Longleaf Pine on Hydric Soils: Short- and Long-Term Effects on Native Ground-Layer Vegetation (CS-1303; Joan Walker

  2. Defense Nanotechnology Research and Development Programs

    Science.gov (United States)

    2005-05-17

    that can be dyed to match specific patterns and woven into uniforms. • An electrospun fiberized adhesive has been developed for fabric laminates...150 by 30 crossbars ). • High moment, magnetic nano-tags have been fabricated that allow DNA fingerprinting without DNA amplification (i.e., the... learned , and DoD guidance is critical to assure both the optimum direction of ongoing research efforts and the optimum leveraging of this knowledge to

  3. Defensive Minefield Planning

    Science.gov (United States)

    1989-06-01

    Minefield Planning by Carlos Vallejo Game Lieutenant, Ecuadorian Navy B. S., Escuela Superior Naval, Ecuador 1980 Submitted in partial fulfillment of...was a superior open-ocean naval force to the North Koreans, defensive minewarfare was able to, at least temporarily, defeat U.S. Navy objectives in...Oswaldo Rosero 1 Unit 8 Coastal Route 1 Monterey, California 93940 77 11. Office of the N’aval Attache 4 Direccion de Educacion 2535 15th. st. N. W

  4. Defense AT and L.

    Science.gov (United States)

    2014-06-01

    investigation. On board is Galactic High Com-missioner Ferris, overseeing the delivery of the medicines to Makus III.” Star Trek fans might recall...these lines from the second episode of the original Star Trek television series that aired in 1966. The show, produced by Gene Roddenberry, challenged...Defense (DoD) supply chain management arena, however, are keenly aware that throughout the Star Trek series, there is never an appearance by the

  5. Plant defense against insect herbivores

    DEFF Research Database (Denmark)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    have adapted to resist plant defenses, and in some cases even sequester the compounds and reuse them in their own defense. Both plant defense and insect adaptation involve metabolic costs, so most plant-insect interactions reach a stand-off, where both host and herbivore survive although......Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar....... Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight...

  6. Plant defense against insect herbivores

    DEFF Research Database (Denmark)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar....... Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight......, defense compounds. These bioactive specialized plant defense compounds may repel or intoxicate insects, while defense proteins often interfere with their digestion. Volatiles are released upon herbivory to repel herbivores, attract predators or for communication between leaves or plants, and to induce...

  7. Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U. S. Environmental Protection Agency Gene-Tox Program

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, F.K.; von Borstel, R.C.; von Halle, E.S.; Parry, J.M.; Siebert, D.; Zetterberg, G.; Barale, R.; Loprieno, N.

    1984-01-01

    This review article with over 200 references summarizes the results of mutation screening tests with 492 chemicals using saccharomyces cerevisiae as the test organism. In addition, an extensive description of S. cerevisiae as a test organism is given. Yeast can be used to study genetic effects both in mitotic and in meiotic cells because it can be cultured as a stable haploid or a stable diploid. The most commonly used genetic endpoint has been mitotic recombination either as mitotic crossing-over or mitotic gene conversion. Data were available on tests with 492 chemicals, of which 249 were positive, as reported in 173 articles or reports. The genetic test/carcinogenicity accuracy was 0.74, based on the carcinogen listing established in the gene-tox program. The yeast tests supplement the bacterial tests for detecting agents that act via radical formation, antibacterial drugs, and other chemicals interfering with chromosome segregation and recombination processes.

  8. NCMS PWB program report surface finishes team task WBS No. 3.1.1: Phase 1, Etching Studies: Chemical etching of copper for improved solderability

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, J.O.; Guilinger, T.R.; Hosking, F.M.; Yost, F.G.; Sorensen, N.R.

    1995-06-01

    Sandia National Laboratories has established a Cooperative Research and Development Agreement with consortium members of the National Center for Manufacturing Sciences (NCMS) to develop fundamental generic technology in the area of printed wiring board materials and surface finishes. Improved solderability of copper substrates is an important component of the Sandia-NCMS program. We are investigating the effects of surface roughness on the wettability and solderability behavior of several different types of copper board finishes. In this paper, we present roughness and solderability characterizations for a variety of chemically-etched copper substrates. Initial testing on six chemical etches demonstrate that surface roughness can be greatly enhanced through chemical etching. Noticeable improvements in solder wettability were observed to accompany increases in roughness. A number of different algorithms and measures of roughness were used to gain insight into surface morphologies that lead to improved solderability.

  9. Defense AT&L. Volume 43, Number 6, November-December 2014

    Science.gov (United States)

    2014-12-01

    to address their issues is outweighed by benefit to the program. Defense AT&L: November–December 2014 12 Think Portfolios , Not Programs Mike...and Logistics The Big IDEA Dynamic Stakeholder Management Think Portfolios , Not Programs Mining Hidden Gems Extract Information Systems’ Value...Think Portfolios , Not Programs Mike Janiga and Pete Modigliani The Department of Defense can foster dy- namic and innovative solutions for tomor- row’s

  10. SETUP, a program of representative laboratory simulations of Titan's atmosphere dedicated to better understand and quantify its chemical evolution pathways

    Science.gov (United States)

    Gazeau, M.; Bahrini, C.; Benilan, Y.; Jolly, A.; Landsheere, X.; Lebert, B.

    2013-12-01

    Atmospheres are enormously complex systems. Therefore, experimental simulations are a welcome tool in the researcher's toolbox since they provide an alternative source to compare with direct measurements and theoretical models. This is important for Titan, since direct measurements are limited and theoretical models often lack important parameters. The advantage of experimental simulations is that they reduce the problem to only the chemical reactions in a certain region by neglecting atmospheric dynamics. The experimental simulations of Titan's atmosphere performed in the frame of the SETUP (French acronym for Experimental and Theoretical Simulations Useful for Planetology) program are the most representative ever achieved towards Titan's condition in term of energy deposition: the coupled N2/CH4 chemistry is initiated in a flow reactor using microwave plasma discharge as well as Ly-alpha photons delivered by a continuous H2/He lamp. The vacuum pumping and measurement system limit the experiment to pressures above 1x10-3 mbar, which corresponds well to the lower thermosphere and below. The experiment is run at ambient temperature which does not correspond directly with any region, however the upper stratosphere and above is the closest match. According to pressure and temperature, SETUP best represents from the upper stratosphere up to the lower thermosphere. The ability to perform in-situ and absolute analysis is another improvement of SETUP over its predecessors: the chemical composition is probed in-situ using cavity ring-down spectroscopy (CRDS, an absolute and highly sensitive laser spectroscopic technique based upon absorption spectroscopy) allowing us to study the evolution of the resulting gas sample. We have chosen to use a difference-frequency generation technique that combines the advantages of decent sensitivity over widely tunable wavelength range in the mid-infrared region. Indeed, numerous molecular species exhibit their fundamental vibrational

  11. Survey and discussion of models applicable to the transport and fate thrust area of the Department of Energy Chemical and Biological Nonproliferation Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    The availability and easy production of toxic chemical and biological agents by domestic and international terrorists pose a serious threat to US national security, especially to civilian populations in and around urban areas. To address this threat, the Department of Energy (DOE) has established the Chemical and Biological Nonproliferation Program (CBNP) with the goal of focusing the DOE`s technical resources and expertise on capabilities to deny, deter, mitigate and respond to clandestine releases of chemical and biological agents. With the intent to build on DOE core competencies, the DOE has established six technology thrust areas within the CBNP Program: Biological Information Resources; Point Sensor Systems; Stand-off Detection; Transport and Fate; Decontamination; and Systems Analysis and Integration. The purpose of the Transport and Fate Thrust is to accurately predict the dispersion, concentration and ultimate fate of chemical and biological agents released into the urban and suburban environments and has two major goals: (1) to develop an integrated and validated state-of-the-art atmospheric transport and fate modeling capability for chemical and biological agent releases within the complex urban environment from the regional scale down to building and subway interiors, and (2) to apply this modeling capability in a broad range of simulation case studies of chemical and biological agent release scenarios in suburban, urban and confined (buildings and subways) environments and provide analysis for the incident response user community. Sections of this report discuss subway transport and fate models; buildings interior transport and fate modeling; models for flow and transport around buildings; and local-regional meteorology and dispersion models.

  12. Designing the Army’s Future Active Duty Weapons of Mass Destruction Response: Is the Defense Chemical, Biological, Radiological, Nuclear and High-Yield Explosives Response Force (DCRF) the Right Force at the Right Time?

    Science.gov (United States)

    2013-06-14

    alternative methods for implementing the force structure, reducing redundancy and waste , and building cooperative training strategies for the CBRNE forces...nuclear detonation, attacks with biological, blister , nerve, and radiological agents, an influenza pandemic, an toxic industrial chemical release, a

  13. 76 FR 65186 - Request for Public Comments on How the Department of Defense Can Improve the Way It Procures...

    Science.gov (United States)

    2011-10-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Request for Public Comments on How the Department of Defense Can Improve the Way It Procures Defense Items... program is an important instrument of U.S foreign policy. It allows the United States to provide...

  14. Allocation Costs Associated with Induced Defense in Phaeocystis globosa (Prymnesiophyceae): the Effects of Nutrient Availability

    OpenAIRE

    Wang, Xiaodong; Wang, Yan; Ou, Linjian; He, Xuejia; Chen, Da

    2015-01-01

    Colony enlargement in Phaeocystis globosa has been considered as an induced defense strategy that reduces its susceptibility to grazers, but allocation costs inflicted by this plastic morphological defense are poorly understood. We conducted experiments in which P. globosa cultures were exposed to chemical cues from copepods, ciliates and heterotrophic dinoflagellates, respectively, under nutrient sufficient and deficient conditions to evaluate allocation costs associated with induced defense...

  15. Phenomenon of Psychological Defense

    Directory of Open Access Journals (Sweden)

    Elena T. Sokolova

    2011-01-01

    Full Text Available The author discusses the controversial issues of formation and functioning of psy¬chological defense mechanisms in ontogenesis and in personality disorders as they are represented in classical and contemporary psychoanalysis, in cognitivism and communication theory. The paper emphasizes the role of cognitive organi¬zation (style, sign-symbolic mediation, representative system of object relations and attachments in individual typological variability of the level organization of ciency of personal and social adaptation, in maturity and mental health of personality

  16. Defensive engagement and perceptual enhancement

    OpenAIRE

    Keil, Andreas; Bradley, Margaret M; Ihssen, Niklas; Heim, Sabine; Vila, Jaime; Guerra, Pedro; Lang, Peter J.

    2010-01-01

    We tested whether visual cortical sensitivity to external cues in the context of an acute defensive reaction is heightened or attenuated. A strong cardiac defense (fear) response was elicited by presenting an abrupt, loud acoustic stimulus following a 10-minute period of quiescence. Electrocortical responses to aversive and neutral pictures following defensive stimulus onset were measured using dense-array EEG. Pictures were flickered at 12.5 Hz to evoke steady-state visual evoked potentials ...

  17. Ballistic Missile Defense System (BMDS)

    Science.gov (United States)

    2015-12-01

    Estimate RDT&E - Research , Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be Determined TY - Then...all ranges and in all phases of flight. Following guidance from the President, the Secretary of Defense approved the Ballistic Missile Defense (BMD...based Midcourse Defense (GMD) system to enhance our capability against Intercontinental Ballistic Missiles. We are currently sustaining 30

  18. Current Chemical Risk Reduction Activities

    Science.gov (United States)

    EPA's existing chemicals programs address pollution prevention, risk assessment, hazard and exposure assessment and/or characterization, and risk management for chemicals substances in commercial use.

  19. Benefits and risks of fish consumption Part II. RIBEPEIX, a computer program to optimize the balance between the intake of omega-3 fatty acids and chemical contaminants.

    Science.gov (United States)

    Domingo, José L; Bocio, Ana; Martí-Cid, Roser; Llobet, Juan M

    2007-02-12

    In recent years, and based on the importance of fish as a part of a healthy diet, there has been a notable promotion of fish and seafood consumption. However, a number of recent studies have shown that fish may be a potential source of exposure to chemical pollutants, some of them with well known adverse effects on human health. Recently, we determined in 14 edible marine species the concentrations of eicosapentaenoic acid (EPA) and docosohexaenoic acid (DHA), as well as those of a number of chemical contaminants: Cd, Hg, Pb, polychlorinated dibenzo-p-dioxins and furans, polychlorinated biphenyls, hexachlorobenzene, polycyclic aromatic hydrocarbons, polychlorinated naphthalenes, polybrominated diphenylethers and polychlorinated diphenylethers. To quantitative establish the intake of these pollutants (risks) versus that of EPA+DHA (benefits), we designed a simple computer program, RIBEPEIX. The concentrations of EPA, DHA, and the chemical pollutants were introduced into the program. We here present how RIBEPEIX may be used as an easy tool to optimize fish consumption: most suitable species, frequency of consumption, and size of meals. RIBEPEIX can be useful not only for professionals (cardiologists, general physicians, nutritionists, toxicologists, etc.), but also for the general population. It is available at: .

  20. Design and accomplishment of the dissertation and graduation defense in seven-year clinical medicine program (pharmacy direction)%七年制临床医学专业(药学方向)学生毕业论文的设计与答辩

    Institute of Scientific and Technical Information of China (English)

    郝国祥; 张庆柱; 邵伟; 张泰松

    2012-01-01

    为了提高七年制临床医学专业(药学方向)学生的培养质量,提高学生的科研与论文写作能力,山东大学药学院对该专业学生的专题实习、毕业论文写作与答辩进行了探索,本文就专题实习的方式与内容、导师组成与选题、毕业论文的撰写与要求,以及论文答辩的组织与实施等方面的问题进行了探讨.%In order to improve the quality of seven-year clinical medicine program (pharmacy direction) students,increase their abilities of research and thesis writing,graduation thesis defense were organized after special practice.This article detailed the special practice and the graduation thesis defense,including the methods and contents of special practice,composition of tutors,selection of dissertation topic,requirements of dissertation writing,organization and implementation of graduation defense.

  1. Interwar U.S. and Japanese National Product and Defense Expenditure

    Science.gov (United States)

    2003-06-01

    Selected investment price indexes for Japan . ................... 19 Figure 7. Japanese defense expenditure in constant yen terms. Amounts are...CIM D0007249.A /Final June 2003 Interwar U.S. and Japanese National Product and Defense Expenditure William D. O’Neil 4825 Mark Center...and Japanese National Product and Defense Expenditure 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT

  2. Lexical Link Analysis (LLA) Application: Improving Web Service to Defense Acquisition Visibility Environment (DAVE)

    Science.gov (United States)

    2015-05-01

    1 LEXICAL LINK ANALYSIS (LLA) APPLICATION: IMPROVING WEB SERVICE TO DEFENSE ACQUISITION VISIBILITY ENVIRONMENT(DAVE) May 13-14, 2015 Dr. Ying...Improving Web Service to Defense Acquisition Visibility Environment (DAVE) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR...to install the LLA/CLA/SSA system as a web service in the Defense Acquisition Visibility Environment (DAVE) test bed via the AT&L eBusiness Center

  3. Thermal transformation of bioactive caffeic acid on fumed silica seen by UV-Vis spectroscopy, thermogravimetric analysis, temperature programmed desorption mass spectrometry and quantum chemical methods.

    Science.gov (United States)

    Kulik, Tetiana V; Lipkovska, Natalia O; Barvinchenko, Valentyna M; Palyanytsya, Borys B; Kazakova, Olga A; Dudik, Olesia O; Menyhárd, Alfréd; László, Krisztina

    2016-05-15

    Thermochemical studies of hydroxycinnamic acid derivatives and their surface complexes are important for the pharmaceutical industry, medicine and for the development of technologies of heterogeneous biomass pyrolysis. In this study, structural and thermal transformations of caffeic acid complexes on silica surfaces were studied by UV-Vis spectroscopy, thermogravimetric analysis, temperature programmed desorption mass spectrometry (TPD MS) and quantum chemical methods. Two types of caffeic acid surface complexes are found to form through phenolic or carboxyl groups. The kinetic parameters of the chemical reactions of caffeic acid on silica surface are calculated. The mechanisms of thermal transformations of the caffeic chemisorbed surface complexes are proposed. Thermal decomposition of caffeic acid complex chemisorbed through grafted ester group proceeds via three parallel reactions, producing ketene, vinyl and acetylene derivatives of 1,2-dihydroxybenzene. Immobilization of phenolic acids on the silica surface improves greatly their thermal stability.

  4. Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

    Science.gov (United States)

    The field of toxicology is on the cusp of a major transformation in how the safety and hazard of chemicals are evaluated for potential effects on human health and the environment. Brought on by the recognition of the limitations of the current paradigm in terms of cost, time, and...

  5. The Department of Defense Commitment to the Destruction and Remediation of Non-Stockpile Chemical Materiel: Can Present Policy and Approaches Effectively Meet the Challenges to Eliminate the Threat to the Public?

    Science.gov (United States)

    2007-11-02

    the destruction of Recovered Chemical Warfare Material. Current projections are that 42 states are impacted by the possible presence of RCWM...the Army. LUCs can impact property values and flexibility for various uses, many communities want remedies that require no restrictions on land use...Huntsville, Al: Headquarters 4 th District USACOE, January 2002. Department of the Army, Army Environmental Command. Army Enviromental Cleanup

  6. Probabilistic safety assessment in the chemical and nuclear industries

    CERN Document Server

    Fullwood, Ralph R

    2000-01-01

    Probabilistic Safety Analysis (PSA) determines the probability and consequences of accidents, hence, the risk. This subject concerns policy makers, regulators, designers, educators and engineers working to achieve maximum safety with operational efficiency. Risk is analyzed using methods for achieving reliability in the space program. The first major application was to the nuclear power industry, followed by applications to the chemical industry. It has also been applied to space, aviation, defense, ground, and water transportation. This book is unique in its treatment of chemical and nuclear risk. Problems are included at the end of many chapters, and answers are in the back of the book. Computer files are provided (via the internet), containing reliability data, a calculator that determines failure rate and uncertainty based on field experience, pipe break calculator, event tree calculator, FTAP and associated programs for fault tree analysis, and a units conversion code. It contains 540 references and many...

  7. Program VODAM for treatment of mineral physico-chemical data, with a special application to the uranium case; Programa VODAM para tratamiento de datos de fisico-quimica mineral. Ejemplo de aplicacion al caso del uranio

    Energy Technology Data Exchange (ETDEWEB)

    Santoma Juncadella, L.

    1972-07-01

    The VODAM program is written in FORTRAN IV language and makes a physico-chemical analysis of waters, for an element or a number of them, under investigation. A thermodynamical data files is incorporated, and is useful for a low temperature range. It is the basic nucleus for a series of programs of physico-chemical interpretation of hydrogeochemical data and automatic construction of equilibrium diagrams. (Author) 13 refs.

  8. Molecular and structural antioxidant defenses against oxidative stress in animals.

    Science.gov (United States)

    Pamplona, Reinald; Costantini, David

    2011-10-01

    In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural and functional factors affecting the "whole" organism, 3) to incorporate, when supportable by evidence, mechanisms into models of life-history trade-offs and maternal/epigenetic inheritance, 4) to highlight the importance of studying the biochemical integration of redox systems, and 5) to discuss the link between maximum life span and antioxidant defenses. The traditional concept of antioxidant defenses emphasizes the importance of the chemical nature of molecules with antioxidant properties. Research in the past 20 years shows that animals have also evolved a high diversity in structural defenses that should be incorporated in research on antioxidant responses to reactive species. Although there is a high diversity in antioxidant defenses, many of them are evolutionary conserved across animal taxa. In particular, enzymatic defenses and heat shock response mediated by proteins show a low degree of variation. Importantly, activation of an antioxidant response may be also energetically and nutrient demanding. So knowledge of antioxidant mechanisms could allow us to identify and to quantify any underlying costs, which can help explain life-history trade-offs. Moreover, the study of inheritance mechanisms of antioxidant mechanisms has clear potential to evaluate the contribution of epigenetic mechanisms to stress response phenotype variation.

  9. Antiviral Defenses in Plants through Genome Editing

    Science.gov (United States)

    Romay, Gustavo; Bragard, Claude

    2017-01-01

    Plant–virus interactions based-studies have contributed to increase our understanding on plant resistance mechanisms, providing new tools for crop improvement. In the last two decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies. More recently, the new genome editing systems (GES) are revolutionizing the scope of tools available to confer virus resistance in plants. The most explored GES are zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats/Cas9 endonuclease. GES are engineered to target and introduce mutations, which can be deleterious, via double-strand breaks at specific DNA sequences by the error-prone non-homologous recombination end-joining pathway. Although GES have been engineered to target DNA, recent discoveries of GES targeting ssRNA molecules, including virus genomes, pave the way for further studies programming plant defense against RNA viruses. Most of plant virus species have an RNA genome and at least 784 species have positive ssRNA. Here, we provide a summary of the latest progress in plant antiviral defenses mediated by GES. In addition, we also discuss briefly the GES perspectives in light of the rebooted debate on genetic modified organisms (GMOs) and the current regulatory frame for agricultural products involving the use of such engineering technologies. PMID:28167937

  10. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

    Science.gov (United States)

    2010-04-21

    ... Regulation Supplement; DoD Pilot Mentor-Protege Program AGENCY: Defense Acquisition Regulations System... Acquisition Regulation Supplement (DFARS) Appendix I, DoD Pilot Mentor-Protege Program; OMB Control Number... Mentor-Protege Program have been met. The purposes of the Program are to (1) provide incentives to...

  11. Defense Science Board Task Force Report on Cyber Defense Management

    Science.gov (United States)

    2016-09-01

    initialeffort. Preferably, this system will be associated with an F-35 wing or Ballistic Missile Defense (BMD) DSB TASK FORCE ON CYBER DEFENSE CHAPTER 4...Warning and Control SystemBCT brigade combat teamBMD Ballistic Missile DefenseBN battalionC&A certification and accreditationC2 command and controlC4ISR...Richard Hale DoD CIO Ms. Jenine Patterson DoD CIO Members Mr. Christopher W. Day Packet Forensics Ms. Lynn A. Dugle Private Consultant Mr. Page Hoeper

  12. National Coastal Mapping Program

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — The U. S. Army Corps of Engineers (USACE) National Coastal Mapping Program (NCMP) is designed to provide high-resolution elevation and imagery data along U.S....

  13. Is an "ideal" service institution image the same for all referral sources? The case of chemical dependency treatment programs.

    Science.gov (United States)

    Johnson, K; LaTour, M S

    1993-01-01

    In a competitive market like chemical dependency treatment, segmenting the professional referral market according to an "ideal" service image may offer a service institution a strategic advantage. Results of this study suggest that while different professionals in a referral market may attach differential importance to the same service feature, a favorable or unfavorable "image" seems to encompass how well both the professional and the professionals' client are treated by the service institution.

  14. 76 FR 38050 - Defense Federal Acquisition Regulation Supplement; Management of Manufacturing Risk in Major...

    Science.gov (United States)

    2011-06-29

    ... Regulation Supplement; Management of Manufacturing Risk in Major Defense Acquisition Programs (DFARS Case... require the approval of the Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C... Government procurement. Mary Overstreet, Editor, Defense Acquisition Regulations System. Therefore, 48...

  15. Defense Weather Satellites: DOD Faces Acquisition Challenges for Addressing Capability Needs

    Science.gov (United States)

    2016-07-07

    design . Our work on the NPOESS program has shown that without clear lines of authority, conflicts between satellite users hampered decisions, such as for...DEFENSE WEATHER SATELLITES DOD Faces Acquisition Challenges for Addressing Capability Needs Statement of Cristina T...Environment, Committee on Science, Space, and Technology, House of Representatives July 2016 DEFENSE WEATHER SATELLITES DOD Faces Acquisition

  16. Autonomous Defensive Space Control via On-Board Artificial Neural Networks

    Science.gov (United States)

    2007-04-01

    AUTONOMOUS DEFENSIVE SPACE CONTROL VIA ON-BOARD ARTIFICIAL NEURAL NETWORKS Michael T. Manor, Major, USAF April 2007...TITLE AND SUBTITLE Sutonomous Defensive Space Control via On-Board Artificial Neural Networks 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...11 HOW ARTIFICIAL NEURAL NETWORKS WORK

  17. 78 FR 65244 - Defense Federal Acquisition Regulation Supplement: Contractor Personnel Supporting U.S. Armed...

    Science.gov (United States)

    2013-10-31

    ... it with the changes in applicability, terminology, and other revisions made by Department of Defense..., including OCS program management, contract support integration, and integration of defense contractor..., terminology aid in determining which groups qualify for different types of Government support and are based...

  18. Human biomonitoring in civil defense; Humanbiomonitoring im Bevoelkerungsschutz

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Michael; Schmiechen, Katharina [Universitaetsmedizin Goettingen (Germany). Arbeits-, Sozial- und Umweltmedizin

    2012-07-01

    The booklet on human biomonitoring (HBM) in civil defense covers the following issues within two sections: (1) general part: definition and importance of human biomonitoring; application in civil defense; practice in a CBRN (chemical, biological, radiation, nuclear) scenario; sampling following a CBRN assignment; HBM for antidote administration; peculiarities of sampling in case of biological agents; microbiological detection procedure; human biomonitoring of radioactive metal isotopes. (2) Special part: substance profiles; list of HBM laboratories; list of poison information centers; questionnaire for exposure assessment in case of dangerous substance accidents; agreement for human biomonitoring examination.

  19. Quadrennial Defense Review and Ballistic Missile Defense Review

    Science.gov (United States)

    2010-03-11

    global defense posture 3 BMDR Highlights • Outlines a strategy and policy framework to – Defend the homeland against limited ballistic missile attack...abroad – Collaborate closely with allies and partners – Pursue a cooperative and tailored global defense posture – Strengthen US civilian capacity...reviews in 2010 – QDR and BMDR released February 1, 2010 – Nuclear Posture Review to be released this spring – Space Posture Review, with Director of

  20. 法学研究生教育中的化学知识%Chemical Knowledge for the Master of Law Program

    Institute of Scientific and Technical Information of China (English)

    王元凤; 柴艳茹; 徐媛媛

    2015-01-01

    化学物证在侦查和审判过程中出现的频率越来越高,它在许多案件的解决过程中都扮演着重要的角色。充分论述了化学知识对于法学研究生教育的必要性,对于法庭化学课程的内容设置进行了详尽的阐述,并从自身的学习及教学经验出发对于法学研究生教育中法庭化学课程的授课技巧进行了全面的总结,以期为我国法学研究生教育的完善和司法文明的进步提供参考。%chemical evidence appears more and more frequently during criminal investigation and even in the courtroom. It plays an important role in case solving. Therefore,it is necessary to include chemical knowledge and chemical - related courses into master of law(LLM)program. In this paper,we discussed the necessity of forensic chemistry courses for graduate students in law;we explored the content of forensic chemistry as detailed as possible; we summarized comprehensively the teaching techniques of forensic chemistry for graduate students in law. The points discussed in this paper can provide some references for the improvement of LLM program and the increase of judicial civilization in china.

  1. Defense AT&L. March-April 2010

    Science.gov (United States)

    2010-04-01

    with Redstone Arsenal, Ala ., to discuss common avionics issues. 59 Defense AT&L: March-April 2010 program test issues will inform both the test...Wright-Patterson Air Force Base, Ohio, could easily collaborate with Redstone Arsenal, Ala ., to discuss common avionics issues if both were members of

  2. A Strategic Defense Initiative Organization Software Testing Initiative

    Science.gov (United States)

    1990-10-01

    Pentagon Washir gton, DC 20301-7100 Other Defense Technical Information Center 2 Cameron Station Alexandria, VA 22314 Dr. Dan Alpert , Director Program in...Science, Technology & Society University of Illinois Room 201 912-1/2 West Illinois Street Urbana, Illinois 61801 IDA General Larry D. Welch, HQ 1 Mr

  3. 76 FR 22878 - Defense Transportation Regulation, Part IV

    Science.gov (United States)

    2011-04-25

    ... Command (USTRANSCOM), DoD. ACTION: Notice. SUMMARY: DOD has issued draft business rules for the electronic... electronic payments for NTS at all Military Services and Coast Guard installations is the goal of the Defense Personal Property Program (DP3). The initial rollout of the TPPS and the electronic payment process for...

  4. Defense pattern of Chinese cork oak across latitudinal gradients: influences of ontogeny, herbivory, climate and soil nutrients.

    Science.gov (United States)

    Wang, Xiao-Fei; Liu, Jian-Feng; Gao, Wen-Qiang; Deng, Yun-Peng; Ni, Yan-Yan; Xiao, Yi-Hua; Kang, Feng-Feng; Wang, Qi; Lei, Jing-Pin; Jiang, Ze-Ping

    2016-01-01

    Knowledge of latitudinal patterns in plant defense and herbivory is crucial for understanding the mechanisms that govern ecosystem functioning and for predicting their responses to climate change. Using a widely distributed species in East Asia, Quercus variabilis, we aim to reveal defense patterns of trees with respect to ontogeny along latitudinal gradients. Six leaf chemical (total phenolics and total condensed tannin concentrations) and physical (cellulose, hemicellulose, lignin and dry mass concentration) defensive traits as well as leaf herbivory (% leaf area loss) were investigated in natural Chinese cork oak (Q. variabilis) forests across two ontogenetic stages (juvenile and mature trees) along a ~14°-latitudinal gradient. Our results showed that juveniles had higher herbivory values and a higher concentration of leaf chemical defense substances compared with mature trees across the latitudinal gradient. In addition, chemical defense and herbivory in both ontogenetic stages decreased with increasing latitude, which supports the latitudinal herbivory-defense hypothesis and optimal defense theory. The identified trade-offs between chemical and physical defense were primarily determined by environmental variation associated with the latitudinal gradient, with the climatic factors (annual precipitation, minimum temperature of the coldest month) largely contributing to the latitudinal defense pattern in both juvenile and mature oak trees.

  5. Defense pattern of Chinese cork oak across latitudinal gradients: influences of ontogeny, herbivory, climate and soil nutrients

    Science.gov (United States)

    Wang, Xiao-Fei; Liu, Jian-Feng; Gao, Wen-Qiang; Deng, Yun-Peng; Ni, Yan-Yan; Xiao, Yi-Hua; Kang, Feng-Feng; Wang, Qi; Lei, Jing-Pin; Jiang, Ze-Ping

    2016-06-01

    Knowledge of latitudinal patterns in plant defense and herbivory is crucial for understanding the mechanisms that govern ecosystem functioning and for predicting their responses to climate change. Using a widely distributed species in East Asia, Quercus variabilis, we aim to reveal defense patterns of trees with respect to ontogeny along latitudinal gradients. Six leaf chemical (total phenolics and total condensed tannin concentrations) and physical (cellulose, hemicellulose, lignin and dry mass concentration) defensive traits as well as leaf herbivory (% leaf area loss) were investigated in natural Chinese cork oak (Q. variabilis) forests across two ontogenetic stages (juvenile and mature trees) along a ~14°-latitudinal gradient. Our results showed that juveniles had higher herbivory values and a higher concentration of leaf chemical defense substances compared with mature trees across the latitudinal gradient. In addition, chemical defense and herbivory in both ontogenetic stages decreased with increasing latitude, which supports the latitudinal herbivory-defense hypothesis and optimal defense theory. The identified trade-offs between chemical and physical defense were primarily determined by environmental variation associated with the latitudinal gradient, with the climatic factors (annual precipitation, minimum temperature of the coldest month) largely contributing to the latitudinal defense pattern in both juvenile and mature oak trees.

  6. Theater Missile Defense Integration Issues

    Science.gov (United States)

    1993-06-01

    high endoatmospheric defense interceptor (HEDI) proposed t earlier. EADTB. Extended Air Defense Test Bed. A computer-based analysis center for...for attacking deeper elements of an aggressors’s ground forces. Known in NATO as Follow-on Force Attack ( FOFA ). JSTARS. Joint surveillance target...AFIA/INKS ATTN. INKS AFIS/INT ATTN: INT AIR hORCE CTR FOR STUDIES & ANALYSIS ATTN: AFSAA/SAKI 9 Dist-1 w^mmmm mmmm^-mmmemH

  7. 32 CFR 2400.45 - Information Security Program Review.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Information Security Program Review. 2400.45 Section 2400.45 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science...

  8. Software User’s Manual for the RAILCAR4.1 Toxic Industrial Chemical Source Characterization Program

    Science.gov (United States)

    2015-04-01

    Establishment  GUI      Graphical User Interface  JECP  Joint Expeditionary Collective Protection  LNG  Liquefied   Natural   Gas   LPG  Liquefied  Propane  Gas ...Thorney Island dense  gas  field trials, as summarized in the Modelers’ Data Archive (MDA)13   Methane ( liquefied   natural   gas  (LNG)) — a flammable...chemical used in the Burro,  Coyote, and Maplin Sands dense  gas  field trials, as summarized in the MDA   Propane ( liquefied  propane  gas  (LPG)) — a

  9. Systems analysis of past, present, and future chemical terrorism scenarios.

    Energy Technology Data Exchange (ETDEWEB)

    Hoette, Trisha Marie

    2012-03-01

    Throughout history, as new chemical threats arose, strategies for the defense against chemical attacks have also evolved. As a part of an Early Career Laboratory Directed Research and Development project, a systems analysis of past, present, and future chemical terrorism scenarios was performed to understand how the chemical threats and attack strategies change over time. For the analysis, the difficulty in executing chemical attack was evaluated within a framework of three major scenario elements. First, historical examples of chemical terrorism were examined to determine how the use of chemical threats, versus other weapons, contributed to the successful execution of the attack. Using the same framework, the future of chemical terrorism was assessed with respect to the impact of globalization and new technologies. Finally, the efficacy of the current defenses against contemporary chemical terrorism was considered briefly. The results of this analysis justify the need for continued diligence in chemical defense.

  10. Environmental chemistry of chemical warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    MacNaughton, M.G.; Brewer, J.H.; Ledbetter-Ferrill, J. [Southwest Research Inst., San Antonio, TX (United States)

    1995-06-01

    This paper summarizes the approach used in the preparation of a Handbook for the Corps of Engineers, Huntsville Division, on the environmental chemistry of chemical warfare agents. The agents GB and HD will be used to illustrate the type of information in the report. Those readers interested in the full report should contact Mr. Arkie Fanning, Huntsville Corps of Engineers at (505) 955-5256. The U.S. Army Corps of Engineers (ACE) has identified approximately 7,200 formerly used defense sites (FUDS) in the United States, some of which are suspected to be contaminated with chemical warfare agents (CWA). The ACE has responsibility for environmental clean-up of FUDS, including site characterization, evaluation and remediation of the site. Thirty-four FUDS and 48 active DOD installations that may contain CWA were identified in an Interim Survey and Analysis Report by the USACMDA Program Manager for Non-Stockpile Chemical Material (NSCM). The chemical agents listed include sulfur mustard (H), lewisite (L), tabun (GA), sarin (GB), VX, hydrogen cyanide (AC), cyanogen chloride (CK), phosgene (CG), BZ, and CS.

  11. Does SO{sub 2} fumigation change the chemical defense of woody plants: the effect of short-term SO{sub 2} fumigation on the metabolism of deciduous Salix Myrsinifolia plants

    Energy Technology Data Exchange (ETDEWEB)

    Julkunen-Tiitto, R.; Lavola, A.; Kainulainen, P. [University of Joensuu, Joensuu (Finland). Dept. of Biology

    1995-08-01

    The effect of a moderate increase in atmospheric sulfur dioxide on the production of phenolic secondary chemicals, soluble sugars and phytomass distribution within plants was investigated in six willow ({ital Salix myrsinifolia Salisb}) clones. The plants were cultivated for 3 weeks under 0.11 ppm of SO{sub 2} (300{mu}g m{sup -3}). The production of salicin and chlorogenic acid was significantly reduced under increased SO{sub 2}. However, salicortin, 2{prime}-O-acetylsalicortin, (+)-catechin and two unknown phenolics did not show any clear trend. The increase in SO{sub 2} did not affect the glucose, fructose and sucrose contents. The final weight of the SO{sub 2}-treatment plants was significantly greater than that of the control plants: the leaf, stem and root phytomass was from 14 to 48% greater under increased SO{sub 2}. All the clones showed the same trend, although there was a significant variation in phytomass production. Results indicate, although not consistently, that even a short-term exposure of enhanced atmospheric SO{sub 2} may change moderately the accumulation pattern of willow phenolics. 20 refs., 2 tabs.

  12. 76 FR 72391 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-11-23

    ... Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Revised Defense Logistics Agency Regulation (DLAR) 1000.22. SUMMARY: On May 18, 2011, the Defense Logistics Agency (DLA) published a Notice...

  13. Technical Soddi Defenses: The Trojan Horse Defense Revisited

    Directory of Open Access Journals (Sweden)

    Chad Steel

    2014-12-01

    Full Text Available In 2004, the Trojan horse defense was at a crossroads, with two child pornography cases where it was successfully employed in the United Kingdom, resulting in acquittals.  The original Trojan horse defense has now become part of the more general “technical SODDI” defense, which includes the possibility of unknown actors using unsecured Wi-Fi connections or having physical access to a computer to perform criminal acts.  In the past ten years, it has failed to be effective in the United States for criminal cases, with no published acquittals in cases where it was the primary defense.  In the criminal cases where it has been used as leverage in plea negotiations, there has been either poor forensics performed by the prosecution or political pressure to resolve a matter.  On the civil side, however, the defense has been wildly successful, effectively shutting down large John Doe copyright infringement litigation against non-commercial violators.  

  14. XMapTools: a MATLAB©-based program for petrology (treatment of X-ray images, chemical and thermobarometric studies)

    Science.gov (United States)

    Lanari, Pierre; Vidal, Olivier; Engi, Martin

    2013-04-01

    Metamorphic rocks are made up of a mosaic of local thermodynamic equilibria, but frequently involving mineral phases that grew at different equilibrium conditions of Pressure (P), Temperature (T), pH and fO2. The identification of relationships between microstructures and metamorphic conditions requires continuous P-T estimates in at least two dimensions (P-T maps). These maps can be derived from standardized X-ray images and superimposed to the observed deformation structures and assemblages. To this end, we present XMapTools (freely available online at http://www.xmaptools.com), a MATLAB©-based graphical user interface program for processing electron microprobe X-ray images. XMapTools provides a convenient and efficient method to standardize X-ray images (raw intensities) into maps of oxide weight percent compositions using Castaing's approach, employing internal standards. The different minerals phases and other parts of the maps such as fractures or mineral boundaries are automatically separated using a K-means clustering approach. A set of ~50 additional functions is provided in the XMapTools package (1) to calculate structural formulas for common minerals from the standardized analyses, and (2) to estimate the P-T conditions of growth or equilibration, with the geothermobarometry functions using multi-equilibrium thermobarometry and empirical thermobarometers from the literature. The program XMapTools can easily be coupled with forward (i.e. pseudosection) and inverse (i.e. multi-equilibrium) modelling calculations to estimate the P-T conditions of crystallization at the microscale using a semi-empirical approach. In addition, two graphical user interface modules Chem2D and TriPlot3D can be used to plot the mineral compositions into binary and ternary diagrams. This presentation introduces XMapTools and includes typical examples of its functionality.

  15. Plant Defense against Herbivorous Pests: Exploiting Resistance and Tolerance Traits for Sustainable Crop Protection.

    Science.gov (United States)

    Mitchell, Carolyn; Brennan, Rex M; Graham, Julie; Karley, Alison J

    2016-01-01

    Interactions between plants and insect herbivores are important determinants of plant productivity in managed and natural vegetation. In response to attack, plants have evolved a range of defenses to reduce the threat of injury and loss of productivity. Crop losses from damage caused by arthropod pests can exceed 15% annually. Crop domestication and selection for improved yield and quality can alter the defensive capability of the crop, increasing reliance on artificial crop protection. Sustainable agriculture, however, depends on reduced chemical inputs. There is an urgent need, therefore, to identify plant defensive traits for crop improvement. Plant defense can be divided into resistance and tolerance strategies. Plant traits that confer herbivore resistance typically prevent or reduce herbivore damage through expression of traits that deter pests from settling, attaching to surfaces, feeding and reproducing, or that reduce palatability. Plant tolerance of herbivory involves expression of traits that limit the negative impact of herbivore damage on productivity and yield. Identifying the defensive traits expressed by plants to deter herbivores or limit herbivore damage, and understanding the underlying defense mechanisms, is crucial for crop scientists to exploit plant defensive traits in crop breeding. In this review, we assess the traits and mechanisms underpinning herbivore resistance and tolerance, and conclude that physical defense traits, plant vigor and herbivore-induced plant volatiles show considerable utility in pest control, along with mixed species crops. We highlight emerging approaches for accelerating the identification of plant defensive traits and facilitating their deployment to improve the future sustainability of crop protection.

  16. Plant defense against herbivorous pests: exploiting resistance and tolerance traits for sustainable crop protection

    Directory of Open Access Journals (Sweden)

    Carolyn Mitchell

    2016-07-01

    Full Text Available Interactions between plants and insect herbivores are important determinants of plant productivity in managed and natural vegetation. In response to attack, plants have evolved a range of defenses to reduce the threat of injury and loss of productivity. Crop losses from damage caused by arthropod pests can exceed 15% annually. Crop domestication and selection for improved yield and quality can alter the defensive capability of the crop, increasing reliance on artificial crop protection. Sustainable agriculture, however, depends on reduced chemical inputs. There is an urgent need, therefore, to identify plant defensive traits for crop improvement. Plant defense can be divided into resistance and tolerance strategies. Plant traits that confer herbivore resistance typically prevent or reduce herbivore damage through expression of traits that deter pests from settling, attaching to surfaces, feeding and reproducing, or that reduce palatability. Plant tolerance of herbivory involves expression of traits that limit the negative impact of herbivore damage on productivity and yield. Identifying the defensive traits expressed by plants to deter herbivores or limit herbivore damage, and understanding the underlying defense mechanisms, is crucial for crop scientists to exploit plant defensive traits in crop breeding. In this review, we assess the traits and mechanisms underpinning herbivore resistance and tolerance, and conclude that physical defense traits, plant vigor and herbivore-induced plant volatiles show considerable utility in pest control, along with mixed species crops. We highlight emerging approaches for accelerating the identification of plant defensive traits and facilitating their deployment to improve the future sustainability of crop protection.

  17. Getting Defense Acquisition Right

    Science.gov (United States)

    2017-01-01

    February 2017 Article from The ITEA Journal “Perspectives on Developmental Test and Evaluation ,” March 2013 Figures and Tables 6 Figure 1. Better...BBP. We make incremental change focused on the biggest problems we see. Then we monitor the results and evaluate progress. We drop or modify ideas...cases, those dollars have gone to higher-priority Service, portfolio or program/activity needs. The result is more capability for the warfighter at

  18. Comparison of the hazards posed to amphibians by the glyphosate spray control program versus the chemical and physical activities of coca production in Colombia.

    Science.gov (United States)

    Brain, Richard A; Solomon, Keith R

    2009-01-01

    This study evaluates the cumulative multifactorial physical and chemical impacts resulting from coca production on amphibian populations in comparison with the potential impacts produced by the herbicide glyphosate (Glyphos), which, mixed with the surfactant Cosmo-Flux, is used in the spray control program for illicit crops in Colombia. Using similar worst-case assumptions for exposure, several other pesticides used for coca production, including mancozeb, lambda cyhalothrin, endosulfan, diazinon, malathion, and chlorpyrifos, were up to 10- to 100-fold more toxic to frogs than the Glyphos-Cosmo-Flux mixture. Comparing hazard quotients based on application rates, several of these compounds demonstrated hazards 3-383 times that of formulated glyphosate. Secondary effects, particularly of insecticides, are also a concern, as these agents selectively target the primary food source of amphibians, which may indirectly impact growth and development. Although the potential chemical impacts by other pesticides are considerable, physical activities associated with coca production, particularly deforestation of primary forests for new coca plots, portend the greatest hazard to amphibian populations. The entire production cycle of cocaine has been linked to ecosystem degradation. The clearing of pristine forests for coca propagation in Colombia is well documented, and some of these regions coincide with those that contain exceptional amphibian biodiversity. This is particularly problematic as coca production encroaches more deeply into more remote areas of tropical rain forest. Transportation of disease, including the chitrid fungus, to these remote regions via human intrusion may also adversely affect amphibian populations. Therefore, the cumulative impacts of coca production, through habitat destruction, application of agrochemicals, and potential transmission of disease, are judged to pose greater risks to amphibian populations in coca-growing regions than the glyphosate

  19. Physical characteristics of calcium oxalate crystals as determinants in structural defense against chewing insects in Medicago truncatula

    Science.gov (United States)

    In addition to the numerous chemical defenses that plants employ to fend off insect herbivores, simple structural components can also play important roles in effective protection. Our investigations have shown that plant crystals of calcium oxalate can function in insect defense. The isolation of ca...

  20. Directed energy missions for planetary defense

    Science.gov (United States)

    Lubin, Philip; Hughes, Gary B.; Eskenazi, Mike; Kosmo, Kelly; Johansson, Isabella E.; Griswold, Janelle; Pryor, Mark; O'Neill, Hugh; Meinhold, Peter; Suen, Jonathan; Riley, Jordan; Zhang, Qicheng; Walsh, Kevin; Melis, Carl; Kangas, Miikka; Motta, Caio; Brashears, Travis

    2016-09-01

    Directed energy for planetary defense is now a viable option and is superior in many ways to other proposed technologies, being able to defend the Earth against all known threats. This paper presents basic ideas behind a directed energy planetary defense system that utilizes laser ablation of an asteroid to impart a deflecting force on the target. A conceptual philosophy called DE-STAR, which stands for Directed Energy System for Targeting of Asteroids and exploration, is an orbiting stand-off system, which has been described in other papers. This paper describes a smaller, stand-on system known as DE-STARLITE as a reduced-scale version of DE-STAR. Both share the same basic heritage of a directed energy array that heats the surface of the target to the point of high surface vapor pressure that causes significant mass ejection thus forming an ejection plume of material from the target that acts as a rocket to deflect the object. This is generally classified as laser ablation. DE-STARLITE uses conventional propellant for launch to LEO and then ion engines to propel the spacecraft from LEO to the near-Earth asteroid (NEA). During laser ablation, the asteroid itself provides the propellant source material; thus a very modest spacecraft can deflect an asteroid much larger than would be possible with a system of similar mission mass using ion beam deflection (IBD) or a gravity tractor. DE-STARLITE is capable of deflecting an Apophis-class (325 m diameter) asteroid with a 1- to 15-year targeting time (laser on time) depending on the system design. The mission fits within the rough mission parameters of the Asteroid Redirect Mission (ARM) program in terms of mass and size. DE-STARLITE also has much greater capability for planetary defense than current proposals and is readily scalable to match the threat. It can deflect all known threats with sufficient warning.

  1. NPS Defense Affordability Panel

    Science.gov (United States)

    2012-05-01

    MEADS CAP AMRAAM (AIM-120) MQ-9 UAS REAPER AMF JTRS Chem Demil -ACWA TRIDENT II MISSILE USMC H-1 UPGRADES LHA 6 JLENS 100 50 0 50 100 150 200 250 300...DDG 1000, E-2D AHE, EFV(2)**, RMS, VH-71* – Air Force: AEHF, C-5 RERP, C-130 AMP, EELV(2), Global Hawk, JASSM, JPATS, WGS – DoD: Chem Demil -ACWA(2...Javelin, JLENS – Navy: H-1 Upgrades – Air Force: AEHF, C-27J, NPOESS, C-130 AMP – DoD: Chem Demil -ACWA, JTRS GMR * This program reported

  2. SQL Injection Defenses

    CERN Document Server

    Nystrom, Martin

    2007-01-01

    This Short Cut introduces you to how SQL injection vulnerabilities work, what makes applications vulnerable, and how to protect them. It helps you find your vulnerabilities with analysis and testing tools and describes simple approaches for fixing them in the most popular web-programming languages. This Short Cut also helps you protect your live applications by describing how to monitor for and block attacks before your data is stolen. Hacking is an increasingly criminal enterprise, and web applications are an attractive path to identity theft. If the applications you build, manage, or guar

  3. Diversifying Defense Dependent Communities

    Science.gov (United States)

    1989-11-01

    MonllI Hall Room 224 Higher Educaion 603271.2155 P 0 Bo 5636 Massachusetts 101 Adams Street Fargo. NO 58105 Jefferson City. MOD 65101 few Jersey RKhard...57069 802 828 3326 608 266 1927 Middlelown PA 17057 Delee Dykstra Bob Surridg 605,677 5287 Virginia Wyoming 71I7/9486336 Department of Planing Instlute...Sector Program Comell University University Park, PA 16802 717 Clark Hall 103 E. Roberts Hall (814) 863-3447 Unversity of Missouti Ithaca. MY 14853

  4. Nano/micromotors for security/defense applications. A review

    OpenAIRE

    Singh, VV; Wang, J

    2015-01-01

    © 2015 The Royal Society of Chemistry. The new capabilities of man-made micro/nanomotors open up considerable opportunities for diverse security and defense applications. This review highlights new micromotor-based strategies for enhanced security monitoring and detoxification of chemical and biological warfare agents (CBWA). The movement of receptor-functionalized nanomotors offers great potential for sensing and isolating target bio-threats from complex samples. New mobile reactive material...

  5. The Inflammasome in Host Defense

    Directory of Open Access Journals (Sweden)

    Gang Chen

    2009-12-01

    Full Text Available Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-inflammatory cytokines such as interleukin (IL-1β and IL-18. Here, we discuss recent advances in the inflammasome field with an emphasis on host defense. We also compare differential requirements for inflammasome activation in dendritic cells, macrophages and monocytes.

  6. Force Structure: Actions Needed to Improve DOD’s Ability to Manage, Assess, and Report on Global Defense Posture Initiatives

    Science.gov (United States)

    2009-07-02

    Representatives Subject: Force Structure: Actions Needed to Improve DOD’s Ability to Manage, Assess, and Report on Global Defense Posture ...as well as the fidelity of the global basing plan given the rapidly changing global security environment. GAO-09-706R Global Defense Posture ...to Manage, Assess, and Report on Global Defense Posture Initiatives 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

  7. Think Portfolios, Not Programs

    Science.gov (United States)

    2014-12-01

    Defense AT&L: November–December 2014 12 Think Portfolios , Not Programs Mike Janiga n Pete Modigliani Report Documentation Page Form ApprovedOMB...00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Think Portfolios , Not Programs 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...warfighter by designing acquisition portfolios that deliver an integrated suite of capabilities. Program executive officers (PEOs) today often focus

  8. Defense Advanced Research Projects Agency Fiscal Year 1978 Research & Development Program. Statement by Dr. George H. Heilmeier, Director Before the Subcommittee on Research & Development of Senate Armed Services Committee

    Science.gov (United States)

    1977-02-01

    Built-up Areas ( MOBA ) -- 111-15 7. Segmented-Magnet Homopolar Machine ------------ 111-16 8. Ferrous Die Casting Program ------------------- 111-16 9...microprocessors capable of optimal use of seeker, target, and end- game geometry data. At the end of the current assessment, DARPA will invest in the...up Areas ( MOBA ). The MOBA program illuminated important deficiencies and uncertainties in our capabilities for urban warfare and explored improvements

  9. What Happens After the Defense?

    DEFF Research Database (Denmark)

    Feldtmann, Birgit

    2015-01-01

    who has attempted to attack the master’s vessel and whose distress is the direct result of lawful self-defense by PCASP? This is the question at the heart of this article, which argues that there are certain post incident obligations and that it is crucial to address these obligations at the flag...

  10. Systemic defense signaling in tomato

    Institute of Scientific and Technical Information of China (English)

    LI Changbao; SUN Jiaqiang; JIANG Hongling; WU Xiaoyan; LI Chuanyou

    2005-01-01

    The wound-inducible expression of proteinase inhibitors (PIs) genes in tomato provides a powerful model system to elucidate the signal transduction pathway of sys- temic defense response. An increasing body of evidence indi- cates that systemin and jasmonic acid (JA) work in the same signaling pathway to activate the expression of PIs and other defense-related genes. However, little is known about how systemin and JA interact to regulate cell to cell communica- tion over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to dissect the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for systemic expression of defense related genes. However, recent genetic approach provided new evidence that jasmonic acid, rather than systemin, functions as the systemic wound signal, and that the peptide systemin works to regulate the biosynthesis of JA.

  11. Multidimensional Perfectionism and Ego Defenses

    Science.gov (United States)

    Dickinson, Wendy L.; Ashby, Jeffrey S.

    2005-01-01

    This study examined the relationship between multidimensional perfectionism and ego defense style among 130 college students. Cluster analysis results facilitated the identification of groups of adaptive perfectionists, maladaptive perfectionists, and non-perfectionists. The researchers found that identified maladaptive perfectionists used…

  12. In Defense of Darwin's Theory.

    Science.gov (United States)

    Naylor, Bruce G.; Handford, Paul

    1985-01-01

    Examines issues regarding the defensibility and utility of natural selection as a scientific theory, focusing on the process of population change over time. Topics considered include criticisms of Darwinian theory, tautology and the meaning of fitness, the ability of theories to predict and explain, and the sufficiency of natural selection. (DH)

  13. BMDO photovoltaics program overview

    Science.gov (United States)

    Caveny, Leonard H.; Allen, Douglas M.

    1994-01-01

    This is an overview of the Ballistic Missile Defense Organization (BMDO) Photovoltaic Program. Areas discussed are: (1) BMDO advanced Solar Array program; (2) Brilliant Eyes type satellites; (3) Electric propulsion; (4) Contractor Solar arrays; (5) Iofee Concentrator and Cell development; (6) Entech linear mini-dome concentrator; and (7) Flight test update/plans.

  14. Host plant species determines symbiotic bacterial community mediating suppression of plant defenses

    Science.gov (United States)

    Chung, Seung Ho; Scully, Erin D.; Peiffer, Michelle; Geib, Scott M.; Rosa, Cristina; Hoover, Kelli; Felton, Gary W.

    2017-01-01

    Herbivore associated bacteria are vital mediators of plant and insect interactions. Host plants play an important role in shaping the gut bacterial community of insects. Colorado potato beetles (CPB; Leptinotarsa decemlineata) use several Solanum plants as hosts in their natural environment. We previously showed that symbiotic gut bacteria from CPB larvae suppressed jasmonate (JA)-induced defenses in tomato. However, little is known about how changes in the bacterial community may be involved in the manipulation of induced defenses in wild and cultivated Solanum plants of CPB. Here, we examined suppression of JA-mediated defense in wild and cultivated hosts of CPB by chemical elicitors and their symbiotic bacteria. Furthermore, we investigated associations between the gut bacterial community and suppression of plant defenses using 16 S rRNA amplicon sequencing. Symbiotic bacteria decreased plant defenses in all Solanum hosts and there were different gut bacterial communities in CPB fed on different host plants. When larvae were reared on different hosts, defense suppression differed among host plants. These results demonstrate that host plants influence herbivore gut bacterial communities and consequently affect the herbivore’s ability to manipulate JA-mediated plant defenses. Thus, the presence of symbiotic bacteria that suppress plant defenses might help CPB adapt to host plants. PMID:28045052

  15. Department of Defense PERSEREC (DOD PERSEREC)

    Data.gov (United States)

    Social Security Administration — The purpose of this agreement is for SSA to verify SSN information for Defense Manpower Data Center (DMDC) of the Department of Defense. DMDC will use the SSA data...

  16. Chemical profiling of chemical warfare agents for forensic purposes

    NARCIS (Netherlands)

    Noort, D.; Reuver, L.P.J. de; Fidder, A.; Tromp, M.; Verschraagen, M.

    2010-01-01

    A program has been initiated towards the chemical profiling of chemical warfare agents, in order to support forensic investigations towards synthesis routes, production sites and suspect chemical suppliers. Within the first stage of the project various chemical warfare agents (VX, sulfur mustard, sa

  17. Continuous and semicontinuous monitoring techniques for particulate matter mass and chemical components: a synthesis of findings from EPA's Particulate Matter Supersites Program and related studies.

    Science.gov (United States)

    Solomon, Paul A; Sioutas, Constantinos

    2008-02-01

    The U.S. Environmental Protection Agency (EPA) established the Particulate Matter (PM) Supersites Program to provide key stakeholders (government and private sector) with significantly improved information needed to develop effective and efficient strategies for reducing PM on urban and regional scales. All Supersites projects developed and evaluated methods and instruments, and significant advances have been made and applied within these programs to yield new insights to our understanding of PM accumulation in air as well as improved source-receptor relationships. The tested methods include a variety of continuous and semicontinuous instruments typically with a time resolution of an hour or less. These methods often overcome many of the limitations associated with measuring atmospheric PM mass concentrations by daily filter-based methods (e.g., potential positive or negative sampling artifacts). Semicontinuous coarse and ultrafine mass measurement methods also were developed and evaluated. Other semicontinuous monitors tested measured the major components of PM such as nitrate, sulfate, ammonium, organic and elemental carbon, trace elements, and water content of the aerosol as well as methods for other physical properties of PM, such as number concentration, size distribution, and particle density. Particle mass spectrometers, although unlikely to be used in national routine monitoring networks in the foreseeable future because of their complex technical requirements and cost, are mentioned here because of the wealth of new information they provide on the size-resolved chemical composition of atmospheric particles on a near continuous basis. Particle mass spectrometers likely represent the greatest advancement in PM measurement technology during the last decade. The improvements in time resolution achieved by the reported semicontinuous methods have proven to be especially useful in characterizing ambient PM, and are becoming essential in allowing scientists to

  18. Roadmap for an EArth Defense Initiative (READI)

    Science.gov (United States)

    Burke, J. D.; Hussain, A.; Soni, A.; Johnson-Freese, J.; Faull, J.; Schmidt, N.; Wilson, T.; Thangavelu, M.

    2015-12-01

    During the 2015 Space Studies Program of the International Space University, a team of thirty-four participants from seventeen countries carried out a team project on the subject of planetary defense against near-Earth object impacts. The READI Project presents the components of a complete architecture representing practical future strategies and methods for protecting our planet and life as we know it. The findings and recommendations of the project are as follows: for detection and tracking, add infrared instruments in space and radar in Earth's southern hemisphere, as well as dedicated ground telescopes and a program for spectroscopic and other characterization of asteroids and comets; for deflection, develop and space-qualify kinetic and nuclear interceptors, as well as long-range laser ablators; for education and outreach, develop programs aimed at the cohort of children aged 6-15 and their parents; and for evacuation and recovery, provide distributed shelters and increased emergency planning. The project recognizes that the enactment of any deflection strategy would require significant international collaboration; thus, we recommend the formation of a Mitigation Action Group (MAG) in addition to the existing organizations IAWN and SMPAG. The MAG should be chartered to recommend deflection strategies to the UN Security Council in the event of an imminent NEO impact and, upon approval, to lead international deflection action.

  19. Chemical modulation of the defensive behavior in the midbrain tectum

    Directory of Open Access Journals (Sweden)

    M L Brandão

    1999-01-01

    Full Text Available Un grupo de estructuras en el sistema nervioso central, incluyendo la amígdala, el hipotálamo medio, el periacueducto dorsal gris, el colículo inferior, y capas profundas del colículo superior, han sido tradicionalmente asociados con la integración de estados aversivos en el cerebro, debido a que las conductas de escape y los comportamientos defensivos o de miedo a menudo se presentan cuando estas áreas son estimuladas eléctrica o químicamente. En general, las respuestas conductuales inducidas por la estimulación de estas estructuras en el tacto medial son acompañadas por incrementos en la presión sanguínea, tasa cardiaca, tasa respiratoria y analgesia. Tanto las respuestas conductuales como las autonómicas son atenuadas por tranquilizantes menores, probablemente a través de un aumento en la neurotransmisión de GABA. Aparte de las interneuronas GABA, que tienen un control inhibitorio de los circuitos neurales responsables por los correlatos conductuales de la aversión, otros mecanismos diversos tales como los mecanismos opioides, neuropéptidos, serotonérgicos y aminoácidos exitatorios también han sido implicados en la regulación de estos procesos. Se han realizado esfuerzos para comprender el modo de acción de estos neurotransmisores en sus múltiples receptores y cómo interactuan entre sí para producir o regular los sustratos neurales de la aversión. En cuanto a la analgesia que acompaña a estos estados aversivos, se sabe que es mediada por mecanismos no-opioídes, particularmente por mecanismos serotonérgicos a través de receptores 5-HT.

  20. Microclimate Cooling and the Aircrew Chemical Defense Ensemble

    Science.gov (United States)

    1986-05-01

    34.■ " - ".* V "> "«"> * » "J * -"«" * * s *JI ’ • v« » .^ .’ VBJ -JI ’^M^M M* rafruilWAXrj|"J(AJir^Alinjrrwrwr»..rwrru<rBfrwrrir.. only HAAT trials with

  1. The Department of Defense Statement on the Science and Technology Program by Dr. Edith W. Martin, Deputy Under Secretary of Defense for Research and Advanced Technology Before the Subcommittee on Research and Development of the Committee on Armed Services of the United States House of Representatives, 98th Congress, Second Session,

    Science.gov (United States)

    1984-03-21

    missile propulsion is the improvement of the burning rate of minimum signature solid propellants. When the ingredients that cause smoke from burning...performance with reduced detection from the smoke signature. L. Training and Personnel System Technology Over the past decade, there has been an increase...8217 .*- - . -s..:&. . o Munitions Effectiveness Methodology: This program asseses the lethality of candidate technologies by realistic target modelling as

  2. 22 CFR 120.6 - Defense article.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Defense article. 120.6 Section 120.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.6 Defense article. Defense article means any item or technical data designated in § 121.1 of this...

  3. Defense Procurement Strategy for a Globalized Industry

    Science.gov (United States)

    2007-11-02

    QDR,” DefenseNews, 8 November 2004, p. 4. 3 Vago Muradain, “Finalizing Transformation,” DefenseNews, 8 November 2004, p. 34. 4 Hugo Posey and Ben...Interavia, Summer 2004, 34-36. Munton, Bob, and Brinley Salzmann. “U.K.’s Growing Contols.” DefenseNews, 25 October 2004, 96. Muradain, Vago

  4. 22 CFR 120.9 - Defense service.

    Science.gov (United States)

    2010-04-01

    ... Defense service. (a) Defense service means: (1) The furnishing of assistance (including training) to foreign persons, whether in the United States or abroad in the design, development, engineering... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Defense service. 120.9 Section 120.9...

  5. Does investment in leaf defenses drive changes in leaf economic strategy? A focus on whole-plant ontogeny.

    Science.gov (United States)

    Mason, Chase M; Donovan, Lisa A

    2015-04-01

    Leaf defenses have long been studied in the context of plant growth rate, resource availability, and optimal investment theory. Likewise, one of the central modern paradigms of plant ecophysiology, the leaf economics spectrum (LES), has been extensively studied in the context of these factors across ecological scales ranging from global species data sets to temporal shifts within individuals. Despite strong physiological links between LES strategy and leaf defenses in structure, function, and resource investment, the relationship between these trait classes has not been well explored. This study investigates the relationship between leaf defenses and LES strategy across whole-plant ontogeny in three diverse Helianthus species known to exhibit dramatic ontogenetic shifts in LES strategy, focusing primarily on physical and quantitative chemical defenses. Plants were grown under controlled environmental conditions and sampled for LES and defense traits at four ontogenetic stages. Defenses were found to shift strongly with ontogeny, and to correlate strongly with LES strategy. More advanced ontogenetic stages with more conservative LES strategy leaves had higher tannin activity and toughness in all species, and higher leaf dry matter content in two of three species. Modeling results in two species support the conclusion that changes in defenses drive changes in LES strategy through ontogeny, and in one species that changes in defenses and LES strategy are likely independently driven by ontogeny. Results of this study support the hypothesis that leaf-level allocation to defenses might be an important determinant of leaf economic traits, where high investment in defenses drives a conservative LES strategy.

  6. The Venturia Apple Pathosystem: Pathogenicity Mechanisms and Plant Defense Responses

    Directory of Open Access Journals (Sweden)

    Gopaljee Jha

    2009-01-01

    Full Text Available Venturia inaequalis is the causal agent of apple scab, a devastating disease of apple. We outline several unique features of this pathogen which are useful for molecular genetics studies intended to understand plant-pathogen interactions. The pathogenicity mechanisms of the pathogen and overview of apple defense responses, monogenic and polygenic resistance, and their utilization in scab resistance breeding programs are also reviewed.

  7. The Budget Scoring Alternatives Financing Methods for Defense Requirements

    Science.gov (United States)

    2007-04-30

    programs, the Department of Defense (DoD) must consider alternative forms of financing, including leases and public - private partnerships (PPPs), to...Åèìáëáíáçå=oÉëÉ~êÅÜW=`ob^qfkd=pvkbodv=clo=fkclojba=`e^kdb====- 4 - = = leases, share-in-savings contracts, and public private partnerships (PPPs), have...to meet the requirements. Alternative Financing Agreements: Public - private Partnerships In August 2003, the Government Accountability Office (GAO

  8. Defense Science Board (DSB) Summer Study Report on Strategic Surprise

    Science.gov (United States)

    2015-07-01

    DSB Summer Study Report on Strategic Surprise July 2015 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden...SUBTITLE DSB Summer Study Report on Strategic Surprise 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Defense Science Board ( DSB ),The Pentagon ,OUSD(AT&L

  9. 1997 Report to the Congress on Ballistic Missile Defense.

    Science.gov (United States)

    2007-11-02

    be modified to the Block IVA TBMD configuration. This area defense program will provide a lower-tier or endoatmospheric intercept capability. The...and ADCP completed operational testing and evaluation at White Sands Missile Range, New Mexico . A successful TMD demonstration was conducted as part of...UOES FY 99) Sea Lower PAC-3 Configuration Three (FUE FY 99) Navy Theater Wide TBMD AEGIS With SM-2 Block IVA (FUE FY 02; UOES Software

  10. Intervención de ergonomía participativa en una empresa del sector químico A participatory ergonomics program in a chemical company

    Directory of Open Access Journals (Sweden)

    Ana M. García

    2012-08-01

    Full Text Available Se describe una intervención de ergonomía participativa iniciada en abril de 2010 en una empresa del sector químico de la Comunidad Valenciana. Se presentó el programa de intervención en la empresa, se acordó el ámbito de la intervención (dos líneas, 24 trabajadores y trabajadoras y se constituyó un grupo de trabajo (Grupo Ergo, formado por personas responsables, técnicos y delegados de prevención de la empresa encargado de guiar la intervención. Se recogió mediante cuestionario información acerca de daños y riesgos ergonómicos en los trabajadores y trabajadoras de los puestos seleccionados. Esta información fue analizada por el Grupo Ergo y discutida posteriormente en círculos de prevención, con la participación de los trabajadores y trabajadoras afectados. En el momento de redactar esta nota, como resultado del proceso se ha acordado ya implementar 16 medidas de mejora en las condiciones de trabajo, algunas de las cuales se han mostrado eficaces según la opinión de algunos de los participantes. Un compromiso firme en prevención por parte de la empresa es condición necesaria para poder llevar a cabo este tipo de programas, de los cuales podrían beneficiarse un número sustancial de trabajadores y trabajadoras en España.We describe a participatory ergonomics program that started in April 2010 in a chemical company located in the autonomous region of Valencia, Spain. The program was introduced in the company, the intervention level was agreed (two working lines, 24 workers and a working group was established (Ergo Group, including managers, technicians and safety representatives in the company with the aim of leading the intervention. A questionnaire was applied to collect information on ergonomic injuries and exposures in workers at the selected working lines. This information was analyzed by the Ergo Group and was later discussed at prevention circles with the direct participation of affected workers. When the present

  11. Costs of defense and a test of the carbon-nutrient balance and growth-differentiation balance hypotheses for two co-occurring classes of plant defense.

    Directory of Open Access Journals (Sweden)

    Tara Joy Massad

    Full Text Available One of the goals of chemical ecology is to assess costs of plant defenses. Intraspecific trade-offs between growth and defense are traditionally viewed in the context of the carbon-nutrient balance hypothesis (CNBH and the growth-differentiation balance hypothesis (GDBH. Broadly, these hypotheses suggest that growth is limited by deficiencies in carbon or nitrogen while rates of photosynthesis remain unchanged, and the subsequent reduced growth results in the more abundant resource being invested in increased defense (mass-balance based allocation. The GDBH further predicts trade-offs in growth and defense should only be observed when resources are abundant. Most support for these hypotheses comes from work with phenolics. We examined trade-offs related to production of two classes of defenses, saponins (triterpenoids and flavans (phenolics, in Pentaclethra macroloba (Fabaceae, an abundant tree in Costa Rican wet forests. We quantified physiological costs of plant defenses by measuring photosynthetic parameters (which are often assumed to be stable in addition to biomass. Pentaclethra macroloba were grown in full sunlight or shade under three levels of nitrogen alone or with conspecific neighbors that could potentially alter nutrient availability via competition or facilitation. Biomass and photosynthesis were not affected by nitrogen or competition for seedlings in full sunlight, but they responded positively to nitrogen in shade-grown plants. The trade-off predicted by the GDBH between growth and metabolite production was only present between flavans and biomass in sun-grown plants (abundant resource conditions. Support was also only partial for the CNBH as flavans declined with nitrogen but saponins increased. This suggests saponin production should be considered in terms of detailed biosynthetic pathway models while phenolic production fits mass-balance based allocation models (such as the CNBH. Contrary to expectations based on the two

  12. Homeland Defense: DOD Needs to Address Gaps in Homeland Defense and Civil Support Guidance

    Science.gov (United States)

    2012-10-01

    tornado, storm, high water , wind-driven water , tidal wave, tsunami, earthquake, volcanic eruption , landslide, mudslide, snowstorm, or drought), or...Secretary of Defense and the Office of the Under Secretary of Defense for Policy on homeland defense and civil support matters, among other things. The...Assistant Secretary of Defense for Global Strategic Affairs is the principal advisor to the Under Secretary of Defense for Policy and the Secretary

  13. Evaluation of the defensive behavior of two honeybee ecotypes using a laboratory test

    Directory of Open Access Journals (Sweden)

    Andere Cecilia

    2002-01-01

    Full Text Available Honeybee defensive behavior is a useful selection criterion, especially in areas with Africanized honeybees (Apis mellifera L. In all genetic improvement programs the selected characters must be measured with precision, and because of this we evaluated a metabolic method for testing honeybee defensive behavior in the laboratory for its usefulness in distinguishing between honeybee ecotypes and selecting honeybees based on their level of defensive responses. Ten honeybee colonies were used, five having been produced by feral queens from a subtropical region supposedly colonized by Africanized honeybees and five by queens from a temperate region apparently colonized by European honeybees. We evaluate honeybee defensive behavior using a metabolic test based on oxygen consumption after stimulation with an alarm pheromone, measuring the time to the first response, time to maximum oxygen consumption, duration of activity, oxygen consumption at first response, maximum oxygen consumption and total oxygen consumption, colonies being ranked according to the values obtained for each variable. Significant (p < 0.05 differences were detected between ecotypes for each variable but for all variables the highest rankings were obtained for colonies of subtropical origin, which had faster and more intense responses. All variables were highly associated (p < 0.05. Total oxygen consumption was the best indicator of metabolic activity for defensive behavior because it combined oxygen consumption and the length of the response. This laboratory method may be useful for evaluating the defensive behavior of honey bees in genetic programs designed to select less defensive bees.

  14. An Evaluation of the Impact of the Preservice Teacher Education Program at the Defense Language Institute Foreign Language Center on the Foreign Language Teaching Beliefs of Preservice Language Instructors

    Science.gov (United States)

    Bey, Claudia

    2011-01-01

    Preservice foreign-language teachers are adults with well-established beliefs. They start teacher-education programs with traditional beliefs about language teaching reflecting their own experiences. The field of foreign-language teaching, however, underwent a paradigm shift from grammar-based to communicative foreign-language instruction.…

  15. Energy Technology Programs: program summaries for 1979

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    The Energy Technology Programs in the BNL Department of Energy and Environment cover a broad range of activities, namely: electrochemical research, chemical energy storage, chemical heat pumps, solar technology, fossil technology, catalytic systems development, space-conditioning technology, and technical support/program management. Summaries of the individual tasks associated with these activities along with publications, significant accomplishments, and program funding levels are presented.

  16. A defense in depth approach to radiation protection for 125I production activities.

    Science.gov (United States)

    Culp, T; Potter, C A

    2001-08-01

    Not all operational radiation protection situations lend themselves to simple solutions. Often a Radiation Protection Program must be developed and implemented for difficult situations. A defense in depth approach to radiation protection was developed for 125I production activities. Defense in depth relies on key radiation protection elements that tend to be mutually supportive and in combination provide reasonable assurance that the overall desired level of protection has been provided. For difficult situations, defense in depth can provide both a reasonable and appropriate approach to radiation protection.

  17. Application of the Raven UAV for chemical and biological detection

    Science.gov (United States)

    Altenbaugh, Ryan; Barton, Jeff; Chiu, Christopher; Fidler, Ken; Hiatt, Dan; Hawthorne, Chad; Marshall, Steven; Mohos, Joe; McHugh, Vince; Nicoloff, Bill

    2010-04-01

    This paper presents the plume tracking algorithms developed for a series of outdoor chemical-stimulant testing conducted at Dugway Proving Ground in 2008 and 2009 employing a Raven UAV equipped with a real-time chemical sensor. The flights were conducted as part of the a program under the sponsorship of the Army JPM NBC Contamination Avoidance and in conjunction with the Army PM-Unmanned Aircraft Systems, the Defense Threat Reduction Agency, and Edgewood Chemical Biological Center. This test demonstrated the Raven's ability to autonomously detect and track a chemical plume during a variety of atmospheric conditions. During the testing, the Raven conducted over a dozen flights, tracking outdoor releases of simulated chemical weapons over significant distances. The Raven was cued to the releases with standoff detection systems through Cursor on Target messages. Upon reaching the plume, the Raven used on-board sensors and on-board meteorological data to track the plume autonomously and determine the extent of the plume. Results were provided in real-time to the UAV operator.

  18. Application of Defense Technology Commonly Used in Boxing Match

    Institute of Scientific and Technical Information of China (English)

    Zhixiao Li[1; Jianjun Liu[2

    2015-01-01

    Boxing defense technology is a kind of techniques to prevent the opponent from attacking successfully. Boxing is a kind of sports that needs close cooperation between attack and defense. Attack is used for defense, where there is no attack, there will be no defense, and vice versa. Defense technology is the foundation of attack technology, therefore, defense is of vital importance in boxing match.

  19. Austere Defense: Challenges and Opportunities

    Science.gov (United States)

    2014-01-01

    military advice while acquiescing to divestitures, and effectively executing the austere defense cuts required by current law through 2019 and...Could it be that our assessments of risk have, over time, become too conservative? In- deed, even with the effects of full sequestration the United... crunch . Look- ing at overhead, as Douglas Macgregor of Politico magazine reminds us, during World War II, only four four-star generals commanded a

  20. Western Hemisphere Defense Policy Statement

    Science.gov (United States)

    2012-10-01

    El Salvador, Guatemala, Honduras , Paraguay, Peru and Uruguay have contributed to or led multi-national security operations and United Nations (UN...impact on regional and global peace and security and reflect the new realities of defense cooperation in the hemisphere. Working with Canada and...Mexico, DoD remains prepared to deter and defeat direct threats to our homeland. We partner with Canada on regional security issues such as an evolving