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Sample records for channel dual focus

  1. Radiation Reaction in a Continuous Focusing Channel

    Science.gov (United States)

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.

    1995-03-01

    We show that the radiation damping rate of the transverse action of a particle in a straight, continuous focusing system is independent of the particle energy, and that no quantum excitation is induced. This absolute damping effect leads to the existence of a transverse ground state to which the particle inevitably decays and yields the minimum beam emittance that one can ever attain, γɛmin = /2mc, limited only by the uncertainty principle. Because of adiabatic invariance, the particle can be accelerated along the focusing channel in its ground state without any radiation energy loss.

  2. Evaluation of the accuracy and repeatability of the dual channel dual focus optical coherence tomography for the whole eye%双通道双焦点光学相干断层扫描仪的研制及其准确性和重复性检测

    Institute of Scientific and Technical Information of China (English)

    杨璇; 杨顺海; 冯旺强; 查屹; 郑海华

    2013-01-01

    Objective To evaluate a custom-buih dual channel dual focus spectral domain optical coherence tomography (OCT) instrument for imaging the whole eye in vivo,to demonstrate the feasibility and repeatability of this OCT instrument to measure anterior chamber depth and axial length compared to the IOLMaster.Methods In a cross-sectional self-control study,21 volunteers (39 eyes) without a history of ocular disease were enrolled.The anterior chamber depth (ACD) and total axial length (AL) were measured by the custom-built dual channel dual focus OCT and IOLMaster on the first day,and then by the OCT on the second day.The measurements of the two instruments were compared and the measurements with the OCT were compared for the 2 days.A paired t test,Pearson correlation analysis and Bland-Altman analysis were used for data analysis.Results The ocular surfaces from the cornea to the retina could be assessed with this newly built dual channel dual focus spectral domain OCT in real time.The mean and standard deviation of the real anterior chamber depth and total axial length measured by the OCT system were 3.09±0.20 mm and 25.34±0.64 mm,respectively.No significant differences were found in the measurements with OCT taken on different days (t=-1.648,1.129; P>0.05).The mean and standard deviation of the anterior chamber depth and total axial length measured by IOLMaster were 3.58±0.21 mm and 25.24±0.65 mm,respectively.The mean and standard deviation of the anterior chamber depth by OCT was 3.64±0.20 mm.There was a significant difference in measuring the anterior chamber depth and total axial length with the OCT and IOLMaster (t=12.942,8.984,P<0.05).There was a high correlation in anterior chamber depth (r=0.990,P<0.01) and total axial length (r=0.997,P<0.01) measurements by the 2 devices.The 95% LoA (limits of agreement) were +0.001 mm to +0.119 mm and-0.018 mm to +0.178 mm for measurements of ACD and AL by the OCT and IOLMaster.Conclusion Real-time whole eye

  3. Compact, Dual Channel, Mid-IR Laser Spectrometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Small Business Innovative Research Phase II proposal seeks to develop a dual channel, compact mid-infrared laser spectrometer for planetary atmosphere...

  4. Compact, Dual Channel, Mid-IR Laser Spectrometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Small Business Innovative Research Phase I proposal seeks to develop a dual channel, compact mid-infrared laser spectrometer for planetary atmosphere...

  5. Radiation Damping in a Focusing Channel

    Science.gov (United States)

    Ruth, Ronald D.

    1996-05-01

    In electron storage rings synchrotron radiation leads to the damping of the three degrees of freedom of the particle trajectory towards a stable closed orbit transversely and a fixed stable phase longitudinally. At the same time, the emission of discrete quanta leads to diffusion in all three degrees of freedom. These two competing effects result in an equilibrium beam emittance that depends upon the parameters of the storage ring. In the case above, the radiation in the bending fields dominates, and the radiation due to the focusing fields is either neglected or taken into account perturbatively. In this talk we study the opposite case, a continuous focusing channel in which the radiation and its reaction are dominated by the strong focusing field. If there is a bending field, it is much weaker than the focusing field. In such focusing systems, we find that the radiation is synchrotron-like for larger betatron oscillation amplitudes and undulator-like for smaller amplitudes. However, quantum excitation is absent for any oscillation amplitude, and the damping exhibits asymmetry in favor of the transverse degree of freedom as the amplitude becomes smaller. In the undulator regime, the damping turns into exponential in the transverse direction, much faster than the total energy damping in this system. In principle, the particle could damp to the transverse ground state of the harmonic oscillator, reaching a minimum normalized emittance, γ ɛ_min = hbar/2mc, limited only by the uncertainty principle. In the case of a bent focusing system, we find that the lack of quantum excitation and asymmetric damping still hold provided that the bending field is sufficiently weak.

  6. Channel characteristics and coordination in three-echelon dual-channel supply chain

    Science.gov (United States)

    Saha, Subrata

    2016-02-01

    We explore the impact of channel structure on the manufacturer, the distributer, the retailer and the entire supply chain by considering three different channel structures in radiance of with and without coordination. These structures include a traditional retail channel and two manufacturer direct channels with and without consistent pricing. By comparing the performance of the manufacturer, the distributer and the retailer, and the entire supply chain in three different supply chain structures, it is established analytically that, under some conditions, a dual channel can outperform a single retail channel; as a consequence, a coordination mechanism is developed that not only coordinates the dual channel but also outperforms the non-cooperative single retail channel. All the analytical results are further analysed through numerical examples.

  7. Research on Cost Information Sharing and Channel Choice in a Dual-Channel Supply Chain

    Directory of Open Access Journals (Sweden)

    Huihui Liu

    2016-01-01

    Full Text Available Many studies examine information sharing in an uncertain demand environment in a supply chain. However there is little literature on cost information sharing in a dual-channel structure consisting of a retail channel and a direct sales channel. Assuming that the retail sale cost and direct sale cost are random variables with a general distribution, the paper investigates the retailer’s choice on cost information sharing in a Bertrand competition model. Based on the equilibrium outcome of information sharing, the manufacturer’s channel choice is discussed in detail. Our paper provides several interesting conclusions. In both single- and dual-channel structures, the retailer has little motivation to share its private cost information which is verified to be valuable for the manufacturer. When the cost correlation between the two channels increases, our analyses show that the manufacturer’s profit improves. However, when channel choice is involved, the value of information could play a different role. The paper finds that a dual-channel structure can benefit the manufacturer only when the cost correlation is sufficiently low. In addition, if the cost correlation is weak, the cost fluctuation will bring out the advantage of a dual-channel structure and adding a new direct channel will help in risk pooling.

  8. Structure selection and coordination in dual-channel supply chains

    Directory of Open Access Journals (Sweden)

    Jingjing Cai

    2015-04-01

    Full Text Available Purpose: This paper investigates the influence of channel structures and channel coordination on the supplier, the retailer and the entire supply chain in the context of two different kinds of marketing models: The common retailer and the exclusive shop.Methodology: With suppliers who manufacture the alternative commodities and retailers in the dual-channel supply chains as the object of the research, this paper compares suppliers' profits, consumer utility without coordination and contrasts suppliers' and retailers' profits with coordination to determine the range of the revenue sharing rates and which parameters are related.Findings: The analysis suggests the preference lists of the supplier and the retailer over channel structures with and without coordination are different, and depend on parameters like channel basic demand, channel cost and channel substitutability.Originality/value: In this research, new sales model for two suppliers should choose the same retailer or the exclusive retailers to sell their commodities.

  9. Numerical Simulation of Dual-Channel Communication of Column Plasma Antenna Excited by a Surface Wave

    Institute of Scientific and Technical Information of China (English)

    DUANMU Gang; ZHAO Changming; LIANG Chao; XU Yuemin

    2014-01-01

    This paper focuses on the application of plasma as wireless antenna.In order to reveal the radiation characteristics of column plasma antenna,we chose the finite-difference timedomain (FDTD) numerical analysis method to simulate radiation impedance and efficiencies of each channel for a few sets of plasma densities and plasma collision frequencies.Simulation results demonstrate that a plasma antenna shares similar characteristics with a metallic antenna in radiation impedance and efficiency of each channel when an appropriate setting is adopted.Unlike a metallic antenna,a plasma antenna is capable of realizing such functions as dynamic reconfiguration,digital control and dual-channel communication.Thus it is possible to carry out dual-channel communication by plasma antenna,indicating a new path for modern intelligent communication.

  10. Focusing-schlieren visualization in a dual-mode scramjet

    Science.gov (United States)

    Kouchi, Toshinori; Goyne, Christopher P.; Rockwell, Robert D.; McDaniel, James C.

    2015-12-01

    Schlieren imaging is particularly suited to measuring density gradients in compressible flowfields and can be used to capture shock waves and expansion fans, as well as the turbulent structures of mixing and wake flows. Conventional schlieren imaging, however, has difficulty clearly capturing such structures in long-duration supersonic combustion test facilities. This is because the severe flow temperatures locally change the refractive index of the window glass that is being used to provide optical access. On the other hand, focusing-schlieren imaging presents the potential of reduced sensitivity to thermal distortion of the windows and to clearly capture the flow structures even during a combustion test. This reduced sensitivity is due the technique's ability to achieve a narrow depth of focus. As part of this study, a focusing-schlieren system was developed with a depth of focus near ±5 mm and was applied to a direct-connect, continuous-flow type, supersonic combustion test facility with a stagnation temperature near 1200 K. The present system was used to successfully visualize the flowfield inside a dual-mode scramjet. The imaging system captured combustion-induced volumetric expansion of the fuel jet and an anchored bifurcated shock wave at the trailing edge of the ramp fuel injector. This is the first time successful focusing-schlieren measurements have been reported for a dual-mode scramjet.

  11. Miniature electrically tunable rotary dual-focus lenses

    Science.gov (United States)

    Zou, Yongchao; Zhang, Wei; Lin, Tong; Chau, Fook Siong; Zhou, Guangya

    2016-03-01

    The emerging dual-focus lenses are drawing increasing attention recently due to their wide applications in both academia and industries, including laser cutting systems, microscopy systems, and interferometer-based surface profilers. In this paper, a miniature electrically tunable rotary dual-focus lens is developed. Such a lens consists of two optical elements, each having an optical flat surface and one freeform surface. The two freeform surfaces are initialized with the governing equation Ar2θ (A is the constant to be determined, r and θ denote the radii and angles in the polar coordinate system) and then optimized by ray tracing technique with additional Zernike polynomial terms for aberration correction. The freeform surfaces are achieved by a single-point diamond turning technique and then a PDMS-based replication process is utilized to materialize the final lens elements. To drive the two coaxial elements to rotate independently, two MEMS thermal rotary actuators are developed and fabricated by a standard MUMPs process. The experimental results show that the MEMS thermal actuator provides a maximum rotation angle of about 8.2 degrees with an input DC voltage of 6.5 V, leading to a wide tuning range for both the two focal lengths of the lens. Specifically, one focal length can be tuned from about 30 mm to 20 mm while the other one can be adjusted from about 30 mm to 60 mm.

  12. Dual Turbo MIMO-OFDM Channel Estimation Based on Puncher Technique via UWA Channels

    Directory of Open Access Journals (Sweden)

    Gang Qiao

    2013-02-01

    Full Text Available In this study, various techniques of UWA (Underwater Acoustic, UWA channel estimation for underwater MIMO-OFDM system are studied. Dual turbo channel estimation algorithm based on channel puncture technique is proposed. In order to judge the criteria of channel compensation, difference between the raw received signal and the re-coded information signal is carried out. The uncertain sub-channels are punched by using channel puncture technique and replaced by the responses estimated by MMSE (Minimum Mean Square Error, MMSE or OMP (Orthogonal Matching Pursuit, OMP algorithms. Compared with the conventional existing algorithms, the proposed algorithm can effectively reduce the occupancy of pilots, offer confined error propagation and significantly increase the stability of the system with Monte Caro simulation. The results of in-tank-experiment further indorse the reliable performance with improved efficiency of 1.51 bits/s/Hz.

  13. Dual Switched Predictive DIR MLSD Receiver for Dynamic Channels

    Directory of Open Access Journals (Sweden)

    Boyle Michael

    2002-01-01

    Full Text Available A linear prefilter can be used to reduce the required complexity of a maximum likelihood sequence detector Viterbi algorithm (MLSD-VA by shortening the overall channel and prefilter impulse response in dynamic communication systems. The combination of channel and prefilter should have the effect of producing a desired impulse response (DIR at the detector. Falconer and Magee (1973 showed that for a finite length DIR there are a limited number of possible DIRs that are optimal. For a DIR of length two symbols, there are only two optimal DIRs, for a length three DIR there exists a range of possibly optimal DIRs. In this paper, we present a novel receiver architecture in which we use two equalisers and two Viterbi detectors. Each equaliser has a different target DIR. A selection device chooses between the output of the two VAs. It is demonstrated that, using the two optimal length two DIRs can be preferable to both switched triple DIR system and adaptive DIR strategies. It is also demonstrated in this paper that there exists a range of environments where adaptive DIR MLSD-VA receivers fail, however the proposed dual switched DIR MLSD-VA is successful in these environments. The efficacy of the switched dual DIR MLSD-VA is also shown using doubly selective fading channels.

  14. Dual channel formation in a laser-triggered spark gap

    Science.gov (United States)

    Kushner, M. J.; Kimura, W. D.; Ford, D. H.; Byron, S. R.

    1985-12-01

    During self-break in spark-gap switches, multiple streamers can form in close proximity to one another. The rate of expansion of these streamers is sufficiently fast that they can interact during the current pulse. To help understand how these closely spaced, expanding spark columns interact, a laser-triggered spark gap has been studied in which two parallel columns (separation 1.3 mm) are simultaneously preionized, resulting in a pair of nearly identical, axisymmetric spark columns. The spark gap (electrode separation 1.2 cm) switches a 100 ns, 40-60 kV, 12-20 kA, 1.5 Ω waterline. Interferograms of the expanding arc channels are obtained with a laser interferometer having a time and spatial resolution of 5 ns and 10 μm, respectively. Voltage and current were measured with an internal capacitive-voltage divider and a current viewing resistor. The interferograms show that for initially identical axisymmetric columns, the individual channels do not merge into a single larger axisymmetric spark column. Instead, regions of high gas density remain inside the combined column long into the recovery period. The columns also do not remain axisymmetric as they grow, indicating a long-range interaction between the channels. The voltage drop and resistance of the dual channel spark gaps changes by less than 15% from that of a single spark channel. A scaling model is presented to explain the resistance measurements and to predict the change in resistance for multichannel spark gaps.

  15. Dual-channel microreactor for gas-liquid syntheses.

    Science.gov (United States)

    Park, Chan Pil; Kim, Dong-Pyo

    2010-07-28

    A microreactor consisting of two microfluidic channels that are separated by a thin membrane is devised for intimate contact between gas and liquid phases. Gas flowing in one microchannel can diffuse into the liquid flowing in the other microchannel through the thin membrane. An oxidative Heck reaction carried out in the dual-channel (DC) microreactor, in which gaseous oxygen plays a key role in the catalytic reaction, shows the significant improvement that can be made over the traditional batch reactor and the conventional segmental microreactor in terms of yield, selectivity, and reaction time. It also allows independent control of the flow of the gaseous reagent. The proposed DC microreactor should prove to be a powerful tool for fully exploring gas-liquid microchemistry.

  16. Dispersion in a bent-solenoid channel with symmetric focusing

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Chun-xi [Argonne National Lab. (ANL), Argonne, IL (United States)

    2001-08-21

    Longitudinal ionization cooling of a muon beam is essential for muon colliders and will be useful for neutrino factories. Bent-solenoid channels with symmetric focusing has been considered for beam focusing and for generating the required dispersion in the ``emittance exchange'' scheme of longitudinal cooling. In this paper, we derive the Hamiltonian that governs the linear beam dynamics of a bent-solenoid channel, solve the single-particle dynamics, and give equations for determining the lattice functions, in particular, the dispersion functions.

  17. New oral anticoagulants and dual antiplatelet therapy: Focus on apixaban.

    Science.gov (United States)

    Pelliccia, Francesco; Rollini, Fabiana; Marazzi, Giuseppe; Greco, Cesare; Gaudio, Carlo; Angiolillo, Dominick J; Rosano, Giuseppe

    2016-12-15

    The combination of AF and coronary artery disease not only is a common clinical setting, it is also a complex setting to deal with anticoagulation and antiplatelet therapy, and it is associated with significantly higher mortality rates. Unfortunately, there are no sufficient data available to optimally guide clinical practice in such settings. This review focuses specifically on newer oral anticoagulants (NOACs) associated with dual antiplatelet therapy (DAPT) in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). There are no randomized studies comparing vitamin K antagonists and NOACs in patients with AF undergoing PCI either for acute coronary syndromes or for stable patients, i.e. those patients who have an indication to receive DAPT. Moreover, new antiplatelet agents such as ticagrelor and prasugrel have entered the market for acute coronary syndromes. So far, there are no large-scale randomized studies published evaluating these newer antiplatelet agents in patients with AF receiving either vitamin K antagonists or NOACs, adding to the uncertainty on how to use these antithrombotics in combination when both coronary artery disease (unstable or stable patients) and AF converge in a given patient. The lack of large outcome trials and the large number of possible combinations are reflected in the wide variety of practices in the real world. To date, given the lack of data, watchfulness when using NOACs as component of DAPT or triple oral antithrombotic therapy is warranted.

  18. Multiple marketing channel conflict with a focus on the internet

    OpenAIRE

    Goldkuhl, Lena

    2005-01-01

    The emergence of electronic commerce has led more and more companies to, in addition to using resellers, add the Internet to sell directly to its end customers, something that inevitably will create channel conflict. The way companies handle such conflict is considered an important success factor. The importance of this issue, along with the lack of research focusing upon it, created the foundation for this study. In addition to the dysfunctional aspects of conflict, this study aimed at captu...

  19. Pricing Decision under Dual-Channel Structure considering Fairness and Free-Riding Behavior

    Directory of Open Access Journals (Sweden)

    Yongmei Liu

    2014-01-01

    Full Text Available Under dual-channel structure, the free-riding behavior based on different service levels between online channel and offline channel cannot be avoided, which would lead to channel unfairness. This study implies that the dual-channel supply chain is built up by online channel controlled by manufacturer and traditional channel controlled by retailer, respectively. Under this channel structure, we rebuild the linear demand function considering free-riding behavior and modify the pricing model based on channel fairness. Then the influences of fair factor and free-riding behavior on manufacturer and retailer pricing and performance are discussed. Finally, we propose some numerical analysis to provide some valuable recommendations for manufacturer and retailer improving channel management performance.

  20. Model: A Dual Focused Intervention for Depression and Addiction.

    Science.gov (United States)

    Lysaught, Eileen; Wodarski, John S.

    1996-01-01

    Describes how adolescents are affected by depression and alcohol dependence and offers a treatment plan for a dual diagnosis. The plan consists of an adolescent group and family program to facilitate and maintain behavioral changes in treatment. The benefits of this treatment and rationale for its application are discussed. (LSR)

  1. Radiation and radiation reaction in continuous focusing channels

    Science.gov (United States)

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.

    1995-06-01

    We show that the radiation damping rate of the transverse action of a particle in a straight, continuous focusing system is independent of the particle energy, and that no quantum excitation is induced. This absolute damping effect leads to the existence of a transverse ground state which the particle inevitably decays to, and yields the minimum beam emittance that one can ever attain, γɛmin=ℏ/2mc, limited only by the uncertainty principle. Due to adiabatic invariance, the particle can be accelerated along the focusing channel in its ground state without any radiation energy loss. These findings may apply to bent systems provided that the focusing field dominates over the bending field.

  2. Cat-eye target imaging system research and dual-channel DSP implementation

    Science.gov (United States)

    Zheng, Zheng; Zhang, Haiyang; Shi, Guang; Han, Lei; Zhao, Changming

    2013-09-01

    In modern warfare, well-equipped and trained snipers have become a mortal malady for the combat troops. How to accurately, timely and quickly find and destroy snipers becomes a research focus of national military experts. In order to effectively detect faint echo signal of cat-eye target and get the snipers' position information in the detection area, a small size of dual-channel active laser detection system with monochrome and color Charge-couple Devices(CCD) is designed, which is based on the laser imaging principle of cat-eye effect, associated tests are also conducted. The dual-channel video capture can obtain more information of target area, while taking advantage of the high sensitivity of monochrome CCD will also provide more accurate grayscale information for the video image processing. In order to achieve the miniaturization of system, we choose a video processing board whose size is only 54mm*90mm as hardware platform to complete the algorithm. For verifying the feasibility and accuracy of algorithm, we ultimately build a full set of experimental detection system. The test results show that the system can accurately detect and mark typical cat-eye target from background under different distances, which verifies the rationality and validity of the proposed system and has certain practicality and promotion in the active laser detection system research areas.

  3. Dual Channel Pulse Coupled Neural Network Algorithm for Fusion of Multimodality Brain Images with Quality Analysis

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    Kavitha SRINIVASAN

    2014-09-01

    Full Text Available Background: In the review of medical imaging techniques, an important fact that emerged is that radiologists and physicians still are in a need of high-resolution medical images with complementary information from different modalities to ensure efficient analysis. This requirement should have been sorted out using fusion techniques with the fused image being used in image-guided surgery, image-guided radiotherapy and non-invasive diagnosis. Aim: This paper focuses on Dual Channel Pulse Coupled Neural Network (PCNN Algorithm for fusion of multimodality brain images and the fused image is further analyzed using subjective (human perception and objective (statistical measures for the quality analysis. Material and Methods: The modalities used in fusion are CT, MRI with subtypes T1/T2/PD/GAD, PET and SPECT, since the information from each modality is complementary to one another. The objective measures selected for evaluation of fused image were: Information Entropy (IE - image quality, Mutual Information (MI – deviation in fused to the source images and Signal to Noise Ratio (SNR – noise level, for analysis. Eight sets of brain images with different modalities (T2 with T1, T2 with CT, PD with T2, PD with GAD, T2 with GAD, T2 with SPECT-Tc, T2 with SPECT-Ti, T2 with PET are chosen for experimental purpose and the proposed technique is compared with existing fusion methods such as the Average method, the Contrast pyramid, the Shift Invariant Discrete Wavelet Transform (SIDWT with Harr and the Morphological pyramid, using the selected measures to ascertain relative performance. Results: The IE value and SNR value of the fused image derived from dual channel PCNN is higher than other fusion methods, shows that the quality is better with less noise. Conclusion: The fused image resulting from the proposed method retains the contrast, shape and texture as in source images without false information or information loss.

  4. Experimental Study of Flow Field at the Outlet of Dual-Channel Burner

    Institute of Scientific and Technical Information of China (English)

    Yao Bin; Wang Hanfeng; Zeng Hancai; Jiao Qingfeng

    2005-01-01

    This paper presents an experimental study result of flow field of a dual-channel burner. In order to solve the ubiquitous problem of bad rigidity of jets in dual-channel burners, wedges with different arrangements and structural parameters were added to different positions at the outlet of the burners. Laser Particle Image Velocimetry (PIV) was used in this study to measure the flow field to investigate influence of the wedges on flow field of the dual-channel burner. Experimental study shows that fixing wedges at both right and left sides of the burner's outlet can increase the intensity of recirculation without changing the size of the recirculation zone and enhance the rigidity of jets via increasing speed of the two primary air jets at the outlet.

  5. Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs.

    Science.gov (United States)

    Nazıroğlu, Mustafa; Demirdaş, Arif

    2015-01-01

    Psychiatric and neurological disorders are mostly associated with the changes in neural calcium ion signaling pathways required for activity-triggered cellular events. One calcium channel family is the TRP cation channel family, which contains seven subfamilies. Results of recent papers have discovered that calcium ion influx through TRP channels is important. We discuss the latest advances in calcium ion influx through TRP channels in the etiology of psychiatric disorders. Activation of TRPC4, TRPC5, and TRPV1 cation channels in the etiology of psychiatric disorders such as anxiety, fear-associated responses, and depression modulate calcium ion influx. Evidence substantiates that anandamide and its analog (methanandamide) induce an anxiolytic-like effect via CB1 receptors and TRPV1 channels. Intracellular calcium influx induced by oxidative stress has an significant role in the etiology of bipolar disorders (BDs), and studies recently reported the important role of TRP channels such as TRPC3, TRPM2, and TRPV1 in converting oxidant or nitrogen radical signaling to cytosolic calcium ion homeostasis in BDs. The TRPV1 channel also plays a function in morphine tolerance and hyperalgesia. Among psychotropic drugs, amitriptyline and capsazepine seem to have protective effects on psychiatric disorders via the TRP channels. Some drugs such as cocaine and methamphetamine also seem to have an important role in alcohol addiction and substance abuse via activation of the TRPV1 channel. Thus, we explore the relationships between the etiology of psychiatric disorders and TRP channel-regulated mechanisms. Investigation of the TRP channels in psychiatric disorders holds the promise of the development of new drug treatments.

  6. An Image Fusion Method Based on NSCT and Dual-channel PCNN Model

    OpenAIRE

    Nianyi Wang; Yide Ma; Weilan Wang; Shijie Zhou

    2014-01-01

    NSCT is one of useful multiscale geometric analysis tools, which takes full advantage of geometric regularity of image intrinsic structures. The dual-channel PCNN is a simplified PCNN model, which can process multiple images by a single PCNN. This saves time in the process of image fusion and cuts down computational complexity. In this paper, we present a new image fusion scheme based on NSCT and dual-channel PCNN. Firstly, the fusion rules of subband coefficients of NSCT are discussed. For t...

  7. Impaired dual tasking in Parkinson's disease is associated with reduced focusing of cortico-striatal activity.

    Science.gov (United States)

    Nieuwhof, Freek; Bloem, Bastiaan R; Reelick, Miriam F; Aarts, Esther; Maidan, Inbal; Mirelman, Anat; Hausdorff, Jeffrey M; Toni, Ivan; Helmich, Rick C

    2017-03-17

    Impaired dual tasking, namely the inability to concurrently perform a cognitive and a motor task (e.g. 'stops walking while talking'), is a largely unexplained and frequent symptom of Parkinson's disease. Here we consider two circuit-level accounts of how striatal dopamine depletion might lead to impaired dual tasking in patients with Parkinson's disease. First, the loss of segregation between striatal territories induced by dopamine depletion may lead to dysfunctional overlaps between the motor and cognitive processes usually implemented in parallel cortico-striatal circuits. Second, the known dorso-posterior to ventro-anterior gradient of dopamine depletion in patients with Parkinson's disease may cause a funnelling of motor and cognitive processes into the relatively spared ventro-anterior putamen, causing a neural bottleneck. Using functional magnetic resonance imaging, we measured brain activity in 19 patients with Parkinson's disease and 26 control subjects during performance of a motor task (auditory-cued ankle movements), a cognitive task (implementing a switch-stay rule), and both tasks simultaneously (dual task). The distribution of task-related activity respected the known segregation between motor and cognitive territories of the putamen in both groups, with motor-related responses in the dorso-posterior putamen and task switch-related responses in the ventro-anterior putamen. During dual task performance, patients made more motor and cognitive errors than control subjects. They recruited a striatal territory (ventro-posterior putamen) not engaged during either the cognitive or the motor task, nor used by controls. Relatively higher ventro-posterior putamen activity in controls was associated with worse dual task performance. These observations suggest that dual task impairments in Parkinson's disease are related to reduced spatial focusing of striatal activity. This pattern of striatal activity may be explained by a loss of functional segregation

  8. DUAL-CHANNEL PARTICLE SIZE AND SHAPE ANALYZER

    Institute of Scientific and Technical Information of China (English)

    Arjen van der Schoot

    2004-01-01

    @@ Fig. 1 shows a newly developed analyzer (Ankersmid CIS-100) that brings together two different measurement channels for accurate size and shape measurement of spherical and non-spherical particles. The size of spherical particles is measured by a HeNe Laser Beam; the size of non-spherical particles is analyzed by Dynamic Video Analysis of the particles' shape.

  9. Characterization of dual-polarization LTE radio over a free-space optical turbulence channel.

    Science.gov (United States)

    Bohata, J; Zvanovec, S; Korinek, T; Mansour Abadi, M; Ghassemlooy, Z

    2015-08-10

    A dual polarization (DP) radio over a free-space optical (FSO) communication link using a long-term evolution (LTE) radio signal is proposed and analyzed under different turbulence channel conditions. Radio signal transmission over the DP FSO channel is experimentally verified by means of error vector magnitude (EVM) statistics. We demonstrate that such a system, employing a 64 quadrature amplitude modulation at the frequency bands of 800 MHz and 2.6 GHz, evinces reliability with LTE signal over the FSO channel is a potential solution for last-mile access or backbone networks, when using multiple-input multiple-output based DP signals.

  10. Realization of dual-channel organic field-effect transistors and their applications to chemical sensing

    Science.gov (United States)

    Jeong, Yeon Taek; Cobb, Brian H.; Lewis, Shannon D.; Dodabalapur, Ananth; Lu, Shaofeng; Facchetti, Antonio; Marks, Tobin J.

    2008-09-01

    We report on the realization of dual-channel organic field-effect transistors (FETs). These devices have a four-terminal configuration with a polymeric semiconductor p-channel, a small molecule semiconductor n-channel, and a polymeric gate dielectric. The polymeric p-channel and the small molecule n-channel are coupled across the gate dielectric. Both the p-FET and the n-FET exhibit acceptable device characteristics at ∣VDS∣⩽50V and ∣VG∣⩽50V, in which the performances of the p-FET and the n-FET are comparable. The p-FET and n-FET respond to isopropyl alcohol and ethanol vapors with significant sensitivities.

  11. Transceiver Design for Dual-Hop Nonregenerative MIMO-OFDM Relay Systems Under Channel Uncertainties

    Science.gov (United States)

    Xing, Chengwen; Ma, Shaodan; Wu, Yik-Chung; Ng, Tung-Sang

    2010-12-01

    In this paper, linear transceiver design for dual-hop non-regenerative (amplify-and-forward (AF)) MIMO-OFDM systems under channel estimation errors is investigated. Second order moments of channel estimation errors in the two hops are first deduced. Then based on the Bayesian framework, joint design of linear forwarding matrix at the relay and equalizer at the destination under channel estimation errors is proposed to minimize the total mean-square-error (MSE) of the output signal at the destination. The optimal designs for both correlated and uncorrelated channel estimation errors are considered. The relationship with existing algorithms is also disclosed. Moreover, this design is extended to the joint design involving source precoder design. Simulation results show that the proposed design outperforms the design based on estimated channel state information only.

  12. Sparse Channel Estimation for Dual-Hop Amplify-and-Forward Cooperative Communiacion Systems

    Directory of Open Access Journals (Sweden)

    Guan Gui

    2013-01-01

    Full Text Available Cooperative transmission is one of key techniques which can improve system capacity and transmit range with limit power in the next-generation communication systems. However, accurate Channel State Information (CSI is necessary at the destination for coherent detection. Consider a Dual-Hop Amplify-and-Forward (DHAF Cooperative Communication System (CCS, traditional linear channel estimation method, e.g., Least Square (LS, based assumption of the rich multipath cascaded channel, is robust and simple while at the cost of low spectrum efficiency. Recent channel measurements have shown that the wireless channel exhibits great sparse in some highdimensional space. In this study, we confirmed that cascaded channel exhibits sparse distribution if the two individual channels are sparse by using representative simulation results. Later, we propose an efficient sparse channel estimation method to take advantage of the inherent sparse prior information in DHAF CCS. Simulation results confirm the superiority of our proposed methods over LS-based linear channel estimation method.

  13. Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

    Directory of Open Access Journals (Sweden)

    Aldo A Rodríguez Menchaca

    2012-09-01

    Full Text Available Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2. Among them are voltage-gated channels, which are crucial for both neuronal and cardiac excitability. Voltage-gated calcium (Cav channels were shown to be regulated bidirectionally by PIP2. On one hand, PIP2 stabilized their activity by reducing current rundown but on the other hand it produced a voltage-dependent inhibition by shifting the activation curve to more positive voltages. For voltage-gated potassium (Kv channels PIP2 was first shown to prevent N-type inactivation. Careful examination of the effects of PIP2 on the activation mechanism of Kv1.2 has shown a similar bidirectional regulation as in the Cav channels. The two effects could be distinguished kinetically, in terms of their sensitivities to PIP2 and by distinct molecular determinants. The rightward shift of the Kv1.2 voltage dependence implicated basic residues in the S4-S5 linker and was consistent with stabilization of the inactive state of the voltage sensor. A third type of a voltage-gated ion channel modulated by PIP2 is the hyperpolarization-activated cyclic nucleotide-gated (HCN channel. PIP2 has been shown to enhance the opening of HCN channels by shifting their voltage-dependent activation toward depolarized potentials. The sea urchin HCN channel, SpIH, showed again a PIP2-mediated bidirectional effect but in reverse order than the depolarization-activated Cav and Kv channels: a voltage-dependent potentiation, like the mammalian HCN channels, but also an inhibition of the cGMP-induced current activation. Just like the Kv1.2 channels, distinct molecular determinants underlied the PIP2 dual effects on SpIH channels. The dual regulation of these very different ion channels, all of which are voltage dependent, points to conserved mechanisms of regulation of these channels by PIP2.

  14. Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).

    Science.gov (United States)

    Rodríguez-Menchaca, Aldo A; Adney, Scott K; Zhou, Lei; Logothetis, Diomedes E

    2012-01-01

    Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidylinositol 4,5-bisphosphate (PIP(2)). Among them are voltage-gated channels, which are crucial for both neuronal and cardiac excitability. Voltage-gated calcium (Cav) channels were shown to be regulated bidirectionally by PIP(2). On one hand, PIP(2) stabilized their activity by reducing current rundown but on the other hand it produced a voltage-dependent inhibition by shifting the activation curve to more positive voltages. For voltage-gated potassium (Kv) channels PIP(2) was first shown to prevent N-type inactivation regardless of whether the fast inactivation gate was part of the pore-forming α subunit or of an accessory β subunit. Careful examination of the effects of PIP(2) on the activation mechanism of Kv1.2 has shown a similar bidirectional regulation as in the Cav channels. The two effects could be distinguished kinetically, in terms of their sensitivities to PIP(2) and by distinct molecular determinants. The rightward shift of the Kv1.2 voltage dependence implicated basic residues in the S4-S5 linker and was consistent with stabilization of the inactive state of the voltage sensor. A third type of a voltage-gated ion channel modulated by PIP(2) is the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel. PIP(2) has been shown to enhance the opening of HCN channels by shifting their voltage-dependent activation toward depolarized potentials. The sea urchin HCN channel, SpIH, showed again a PIP(2)-mediated bidirectional effect but in reverse order than the depolarization-activated Cav and Kv channels: a voltage-dependent potentiation, like the mammalian HCN channels, but also an inhibition of the cGMP-induced current activation. Just like the Kv1.2 channels, distinct molecular determinants underlied the PIP(2) dual effects on SpIH, with the proximal C-terminus implicated in the

  15. The dual effects of leading for safety: The mediating role of employee regulatory focus.

    Science.gov (United States)

    Kark, Ronit; Katz-Navon, Tal; Delegach, Marianna

    2015-09-01

    This study examined the underlying mechanisms through which transformational and transactional leadership influence employee safety behaviors. Linking leadership theory with self-regulatory focus (SRF) theory, we examined a model of dual effects of leadership on safety initiative and safety compliance behaviors as mediated by promotion and prevention self-regulations. We conducted an experimental study (N = 107), an online study (N = 99) and a field study (N = 798 employees and 49 managers). Results demonstrated that followers' situational promotion focus mediated the positive relationship between transformational leadership and safety initiative behaviors. Through all 3 studies, transactional active leadership was positively associated with followers' situational prevention focus, however, the association between followers' prevention focus and safety compliance behaviors was inconsistent, showing the expected mediation relationships in the experimental setting, but not in the online and field studies. We discuss theoretical and practical implications of the findings.

  16. Pricing Decisions of a Dual-Channel Closed-Loop Supply Chain under Uncertain Demand of Indirect Channel

    Directory of Open Access Journals (Sweden)

    Jie Gao

    2016-01-01

    Full Text Available The dual-channel closed-loop supply chain (CLSC which is composed of one manufacturer and one retailer under uncertain demand of an indirect channel is constructed. In this paper, we establish three pricing models under decentralized decision making, namely, the Nash game between the manufacturer and the retailer, the manufacturer-Stackelberg game, and the retailer-Stackelberg game, to investigate pricing decisions of the CLSC in which the manufacturer uses the direct channel and indirect channel to sell products and entrusts the retailer to collect the used products. We numerically analyze the impact of customer acceptance of the direct channel (θ on pricing decisions and excepted profits of the CLSC. The results show that when the variable θ changes in a certain range, the wholesale price, retail price, and expected profits of the retailer all decrease when θ increases, while the direct online sales price and manufacturer’s expected profits in the retailer-Stackelberg game all increase when θ increases. However, the optimal recycling transfer price and optimal acquisition price of used product are unaffected by θ.

  17. A tone-aided dual vestigial sideband system for digital communications on fading channels

    Science.gov (United States)

    Hladik, Stephen M.; Saulnier, Gary J.; Rafferty, William

    1989-01-01

    A spectrally efficient tone-aided dual vestigial sideband (TA/DVSB) system for digital data communications on fading channels is presented and described analytically. This PSK (phase-shift-keying) system incorporates a feed-forward, tone-aided demodulation technique to compensate for Doppler frequency shift and channel- induced, multipath fading. In contrast to other tone-in-band-type systems, receiver synchronization is derived from the complete data VSBs. Simulation results for the Rician fading channel are presented. These results demonstrate the receiver's ability to mitigate performance degradation due to fading and to obtain proper data carrier synchronization, suggesting that the proposed TA/DVSB system has promise for this application. Simulated BER (bit-error rate) data indicate that the TA/DVSB system effectively alleviates the channel distortions of the land mobile satellite application.

  18. Comparison of Dual-Channel Supply Chain Structures: E-Commerce Platform as Different Roles

    Directory of Open Access Journals (Sweden)

    Cong Wang

    2016-01-01

    Full Text Available E-commerce platforms can act as an e-tailer or a third-party intermediary that charge a commission and allow manufacturers to sell products on their platform directly. These two forms of dual-channel supply chain structures have different impacts on decisions and profits of manufacturers and traditional retailers. This paper establishes different Stackelberg game models for both dual-channel supply chain structures and achieves the equilibrium results. The results state that both structures can increase the consumer surplus and social welfare. More importantly, when the platform acts as an e-tailer, the manufacturer and the traditional retailer can form a “win-win” situation. Nevertheless, when the platform acts as a third-party intermediary allowing manufacturers to sell products on the platform directly, it is bound to harm the interests of the traditional retailer.

  19. The effects of dual-channel coupling on the transition from amplitude death to oscillation death

    Science.gov (United States)

    Chen, Jiangnan; Liu, Weiqing; Zhu, Yun; Xiao, Jinghua

    2016-07-01

    Oscillation quenching including amplitude death (AD) and oscillation death (OD) in addition to the transition processes between them have been hot topics in aspect of chaos control, physical and biological applications. The effects of dual-channel coupling on the AD and OD dynamics regimes, and their transition processes in coupled nonidentical oscillators are explored numerically and theoretically. Our results indicate that an additional repulsive coupling tends to shrink the AD domain while it enlarges the OD domain, however, an additional attractive coupling acts inversely. As a result, the transitions from AD to OD are replaced by transitions from oscillation state (OS) to AD or from OS to OD in the dual-channel coupled oscillators with different frequency mismatches. Our results are helpful to better understand the control of AD and OD and their transition processes.

  20. Voltage and Calcium Dual Channel Optical Mapping of Cultured HL-1 Atrial Myocyte Monolayer

    Science.gov (United States)

    Zhao, Weiwei; Fast, Vladimir G.; Ye, Tong; Ai, Xun

    2015-01-01

    Optical mapping has proven to be a valuable technique to detect cardiac electrical activity on both intact ex vivo hearts and in cultured myocyte monolayers. HL-1 cells have been widely used as a 2-Dimensional cellular model for studying diverse aspects of cardiac physiology. However, it has been a great challenge to optically map calcium (Ca) transients and action potentials simultaneously from the same field of view in a cultured HL-1 atrial cell monolayer. This is because special handling and care is required to prepare healthy cells that can be electrically captured and optically mapped. Therefore, we have developed an optimal working protocol for dual channel optical mapping. In this manuscript, we have described in detail how to perform the dual channel optical mapping experiment. This protocol is a useful tool to enhance the understanding of action potential propagation and Ca kinetics in arrhythmia development. PMID:25867896

  1. Performance analysis of dual-hop relaying systems in the presence of Co-channel interference

    KAUST Repository

    Ikki, Salama Said

    2010-12-01

    In this paper, we investigate the effect of co-channel interference on the performance of dual-hop communications with amplify-and-forward relaying. Based on the derivation of the effective signal-to-interference-plus-noise ratio (SINR) at the destination node of the system, taking into account co-channel interference, we obtain expressions for the error and outage probabilities. Moreover, we study the performance of the system in the high SINR regime. Monte-Carlo simulations are further provided and confirm the accuracy of the analytical results. ©2010 IEEE.

  2. Interface For Dual-Channel MIL-STD-1553 Data Bus

    Science.gov (United States)

    Davies, Bryan L.; Heaps, Timothy L.

    1992-01-01

    Digital electronic subsystem made of commercially available programmable logic arrays and discrete logic devices serves as interface between microprocessor and dual-channel MIL-STD-1553 data bus. Subsystem consumes only 800 mW of power. Provides flexibility in that it is controllable via firmware. Includes only two reading-and-writing ports: one for status and control signals, other for transmission and reception of data.

  3. An Image Fusion Method Based on NSCT and Dual-channel PCNN Model

    Directory of Open Access Journals (Sweden)

    Nianyi Wang

    2014-02-01

    Full Text Available NSCT is one of useful multiscale geometric analysis tools, which takes full advantage of geometric regularity of image intrinsic structures. The dual-channel PCNN is a simplified PCNN model, which can process multiple images by a single PCNN. This saves time in the process of image fusion and cuts down computational complexity. In this paper, we present a new image fusion scheme based on NSCT and dual-channel PCNN. Firstly, the fusion rules of subband coefficients of NSCT are discussed. For the fusion rule of low frequency coefficients, the maximum selection rule (MSR is used. Then, for the fusion rule of high frequency coefficients, spatial frequency (SF of each high frequency subband is considered as the gradient features of images to motivate dual-channel PCNN networks and generate pulse of neurons. At last, fused image is obtained by using the inverse NSCT transform. In order to show that the proposed method can deal with image fusion, we used two pairs of images as our experimental subjects. The proposed method is compared with other five methods. The performance of various methods is mathematically evaluated by using four image quality evaluation criteria. Experimental comparisons conducted on different fusion methods prove the effectiveness of the proposed fusion method

  4. Effects of Dual-Channel Functional Electrical Stimulation on Gait Performance in Patients with Hemiparesis

    Directory of Open Access Journals (Sweden)

    Shmuel Springer

    2012-01-01

    Full Text Available The study objective was to assess the effect of functional electrical stimulation (FES applied to the peroneal nerve and thigh muscles on gait performance in subjects with hemiparesis. Participants were 45 subjects (age 57.8 ± 14.8 years with hemiparesis (5.37 ± 5.43 years since diagnosis demonstrating a foot-drop and impaired knee control. Thigh stimulation was applied either to the quadriceps or hamstrings muscles, depending on the dysfunction most affecting gait. Gait was assessed during a two-minute walk test with/without stimulation and with peroneal stimulation alone. A second assessment was conducted after six weeks of daily use. The addition of thigh muscles stimulation to peroneal stimulation significantly enhanced gait velocity measures at the initial and second evaluation. Gait symmetry was enhanced by the dual-channel stimulation only at the initial evaluation, and single-limb stance percentage only at the second assessment. For example, after six weeks, the two-minute gait speed with peroneal stimulation and with the dual channel was 0.66 ± 0.30 m/sec and 0.70 ± 0.31 m/sec, respectively (. In conclusion, dual-channel FES may enhance gait performance in subjects with hemiparesis more than peroneal FES alone.

  5. Estimation of FBMC/OQAM fading channels using dual Kalman filters.

    Science.gov (United States)

    Aldababseh, Mahmoud; Jamoos, Ali

    2014-01-01

    We address the problem of estimating time-varying fading channels in filter bank multicarrier (FBMC/OQAM) wireless systems based on pilot symbols. The standard solution to this problem is the least square (LS) estimator or the minimum mean square error (MMSE) estimator with possible adaptive implementation using recursive least square (RLS) algorithm or least mean square (LMS) algorithm. However, these adaptive filters cannot well-exploit fading channel statistics. To take advantage of fading channel statistics, the time evolution of the fading channel is modeled by an autoregressive process and tracked by Kalman filter. Nevertheless, this requires the autoregressive parameters which are usually unknown. Thus, we propose to jointly estimate the FBMC/OQAM fading channels and their autoregressive parameters based on dual optimal Kalman filters. Once the fading channel coefficients at pilot symbol positions are estimated by the proposed method, the fading channel coefficients at data symbol positions are then estimated by using some interpolation methods such as linear, spline, or low-pass interpolation. The comparative simulation study we carried out with existing techniques confirms the effectiveness of the proposed method.

  6. Estimation of FBMC/OQAM Fading Channels Using Dual Kalman Filters

    Directory of Open Access Journals (Sweden)

    Mahmoud Aldababseh

    2014-01-01

    Full Text Available We address the problem of estimating time-varying fading channels in filter bank multicarrier (FBMC/OQAM wireless systems based on pilot symbols. The standard solution to this problem is the least square (LS estimator or the minimum mean square error (MMSE estimator with possible adaptive implementation using recursive least square (RLS algorithm or least mean square (LMS algorithm. However, these adaptive filters cannot well-exploit fading channel statistics. To take advantage of fading channel statistics, the time evolution of the fading channel is modeled by an autoregressive process and tracked by Kalman filter. Nevertheless, this requires the autoregressive parameters which are usually unknown. Thus, we propose to jointly estimate the FBMC/OQAM fading channels and their autoregressive parameters based on dual optimal Kalman filters. Once the fading channel coefficients at pilot symbol positions are estimated by the proposed method, the fading channel coefficients at data symbol positions are then estimated by using some interpolation methods such as linear, spline, or low-pass interpolation. The comparative simulation study we carried out with existing techniques confirms the effectiveness of the proposed method.

  7. Experimental demonstration of tunable homodyne detection of WDM and dual-polarization PSK channels by automatically locking the channels to a local pump laser using nonlinear mixing.

    Science.gov (United States)

    Almaiman, Ahmed; Ziyadi, Morteza; Mohajerin-Ariaei, Amirhossein; Cao, Yinwen; Chitgarha, Mohammad Reza; Liao, Peicheng; Bao, Changjing; Shamee, Bishara; Ahmed, Nisar; Alishahi, Fatemeh; Fallahpour, Ahmad; Akasaka, Youichi; Yang, Jeng-Yuan; Sekiya, Motoyoshi; Touch, Joseph D; Tur, Moshe; Langrock, Carsten; Fejer, Martin M; Willner, Alan E

    2016-06-15

    This Letter proposes a method for tunable automatically locked homodyne detection of wavelength-division multiplexing (WDM) dual-polarization (DP) phase-shift keyed (PSK) channels using nonlinear mixing. Two stages of periodically poled lithium niobate (PPLN) waveguides and an LCoS filter enable automatic phase locking of the channels to a local laser.

  8. Evaluation of in-channel amperometric detection using a dual-channel microchip electrophoresis device and a two-electrode potentiostat for reverse polarity separations.

    Science.gov (United States)

    Meneses, Diogenes; Gunasekara, Dulan B; Pichetsurnthorn, Pann; da Silva, José A F; de Abreu, Fabiane C; Lunte, Susan M

    2015-02-01

    In-channel amperometric detection combined with dual-channel microchip electrophoresis is evaluated using a two-electrode isolated potentiostat for reverse polarity separations. The device consists of two separate channels with the working and reference electrodes placed at identical positions relative to the end of the channel, enabling noise subtraction. In previous reports of this configuration, normal polarity and a three-electrode detection system were used. In the two-electrode detection system described here, the electrode in the reference channel acts as both the counter and reference. The effect of electrode placement in the channels on noise and detector response was investigated using nitrite, tyrosine, and hydrogen peroxide as model compounds. The effects of electrode material and size and type of reference electrode on noise and the potential shift of hydrodynamic voltammograms for the model compounds were determined. In addition, the performance of two- and three-electrode configurations using Pt and Ag/AgCl reference electrodes was compared. Although the signal was attenuated with the Pt reference, the noise was also significantly reduced. It was found that lower LOD were obtained for all three compounds with the dual-channel configuration compared to single-channel, in-channel detection. The dual-channel method was then used for the detection of nitrite in a dermal microdialysis sample obtained from a sheep following nitroglycerin administration.

  9. Optimally enhanced heating for focused ultrasound surgery with split foci, dual-frequency, or multi foci

    Science.gov (United States)

    Lu, Mingzhu; Guan, Yubo; Dong, Tengju; Liu, Fenfen; Wan, Mingxi

    2017-03-01

    To substantially enhance heating in HIFU treatment, several methods such as split foci, multi foci, and dual-frequency modes are used. The enhanced-cavitation heating protocols are implemented experimentally in BSA gel-phantom using four-element split-focus array. Using dual frequency of 1.2 and 2.4 MHz, the superimposing of two frequency pressures at confocal region can enhance nucleation cavitation and inertial cavitation activity. When using 135° phase shift combined with dual frequency of 1.2 and 2.4 MHz, the peak negative pressure reach maximum due to peak-negative pressures of two frequencies occur at same time, resulting strong cavitation activities. When using dual frequency of 1.2 and 2.4 MHz, 25-Hz pulse-repetition frequency (PRF), both 135° and 180° phase shift protocols, the experiment results show the largest lesion size of 10.5 × 10.5 × 11 mm3, quickest lesion inception time of less than 0.2 s, therefore, both 135° and 180° phase shift protocols are most efficient in enhanced-cavitation heating. The filtered-PCD mean square waveforms reveal that the strong inertial-cavitation activities involve in those two treatments. The lesion size of four foci of 180° phase shift, single frequency, 25 Hz PRF, is 2 times that of 0° phase shift, single frequency even if the peak intensity of 180° case is half less than that of 0° phase shift case. When arrange multi foci using phased array in a style of a wavelength distance between neighbor foci in focal plane, the result is the same as that using split foci of 180° phase shift and single frequency.

  10. A nanoscale dual-channel trench (DCT) MOSFET for analog/RF applications

    Science.gov (United States)

    Adhikari, Manoj Singh; Singh, Yashvir

    2015-12-01

    In this paper, we propose a dual-channel trench MOSFET (DCT-MOSFET) on SOI for high-frequency small signal analog applications. The gate of device is placed in a trench which creates two n-channels in p-base carrying drain current in parallel. Simultaneous conduction of two-channels provides substantial improvement in performance parameters. Based on two-dimensional simulations, a 60 nm DCT-MOSFET is demonstrated to achieve 92% higher drain current, twofold increase in peak transconductance, 67% rise in transconductance-to-drain current ratio, 47% higher intrinsic voltage gain, 90% improvement in cut-off frequency and 2.1 times higher maximum oscillation frequency as compared to the conventional MOSFET.

  11. Joint Scheduling for Dual-Hop Block-Fading Broadcast Channels

    KAUST Repository

    Ammar, Zafar

    2012-09-16

    In this paper, we propose joint user-and-hop scheduling over dual-hop block-fading broadcast channels in order to exploit multi-user diversity gains and multi-hop diversity gains all together. To achieve this objective, the first and second hops are scheduled opportunistically based on the channel state information and as a prerequisite we assume that the relay, which is half-duplex and operates using decode-and-forward, is capable of storing the received packets from the source until the channel condition of the destined user becomes good to be scheduled. We formulate the joint scheduling problem as maximizing the weighted sum of the long term achievable rates by the users under a stability constraint, which means that on the long term the rate received by the relay should equal the rate transmitted by it, in addition to constant or variable power constraints. We show that this problem is equivalent to a single-hop broadcast channel by treating the source as a virtual user with an optimal priority weight that maintains the stability constraint. We show how to obtain the source weight either off-line based on channel statistics or on real-time based on channel measurements. Furthermore, we consider special cases including the maximum sum rate scheduler and the proportional fair scheduler. We demonstrate via numerical results that our proposed joint scheduling scheme enlarges the rate region as compared with a scheme that employs multi-user scheduling alone.

  12. Measuring diffusion with polarization-modulation dual-focus fluorescence correlation spectroscopy.

    Science.gov (United States)

    Korlann, You; Dertinger, Thomas; Michalet, Xavier; Weiss, Shimon; Enderlein, Jörg

    2008-09-15

    We present a new technique, polarization-modulation dual-focus fluorescence correlation spectroscopy (pmFCS), based on the recently intro-duced dual-focus fluorescence correlation spectroscopy (2fFCS) to measure the absolute value of diffusion coefficients of fluorescent molecules at pico- to nanomolar concentrations. Analogous to 2fFCS, the new technique is robust against optical saturation in yielding correct values of the diffusion coefficient. This is in stark contrast to conventional FCS where optical saturation leads to an apparent decrease in the determined diffusion coefficient with increasing excitation power. However, compared to 2fFCS, the new technique is simpler to implement into a conventional confocal microscope setup and is compatible with cw-excitation, only needing as add-ons an electro-optical modulator and a differential interference contrast prism. With pmFCS, the measured diffusion coefficient (D) for Atto655 maleimide in water at 25?C is determined to be equal to (4.09 +/- 0.07) x 10(-6)cm(2)/s, in good agreement with the value of 4.04 x 10-6cm2/s as measured by 2fFCS.

  13. Manualized treatment for substance abusers with personality disorders: dual focus schema therapy.

    Science.gov (United States)

    Ball, S A

    1998-01-01

    The presence of an untreated personality disorder may be associated with worse compliance and outcome in substance abuse treatment. Therapeutic attention to the symptoms of personality disorder may reduce the severity of substance abuse and other Axis I symptoms which potentially contribute to relapse. A 24-week manual-guided individual cognitive-behavioral therapy approach has been developed that integrates relapse prevention with targeted intervention for early maladaptive schemas (enduring negative beliefs about oneself, others, and events) and coping styles. This Dual Focus Schema Therapy is being compared to 12-Step Drug Counseling for opioid-dependent individuals with personality disorders in an ongoing study funded by the National Institute on Drug Abuse. This article reviews Young's (1994) schema-focused theory and approach and summarizes the treatment manual, which integrates relapse prevention for substance abuse.

  14. 多渠道环境下产品分销及协调策略%Product Distribution and Coordination Strategies in Dual-channel Supply Chain

    Institute of Scientific and Technical Information of China (English)

    李智; 徐庆; 马骋

    2014-01-01

    We build a dual -channel supply chain model consisting of a manufacturer and a retailer in this paper .We propose three different stucture in different context .In this study,we focus on the strategic roles played by product distribution and coordinative structure with profit sharing in the dual -channel context .We analyse model to show that the brand differentiation is not a dominant distribution strategy to coordinate the channel conflict .The manufacturer employs a coorperative structure with profit sharing to maximize the entire distribution of channel profit and create a win -win channel strategy for each channel member .%文中构建了由一个制造商与一个零售商组成的双渠道供应链模型,提出了三种不同条件下的决策模型。研究了双渠道环境下产品分销及协调结构中的利益分享。研究发现品牌差异化并不是协调渠道冲突的主导分销策略。制造商采用协调结构并进行利益分享可以最大化整个供应链的利益,同时对于每个渠道成员都是双赢的。

  15. Analysis of continuously rotating quadrupole focusing channels using generalized Courant-Snyder theory

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Moses; Qin, Hong; Gilson, Erik; Davidson, Ronald C.

    2013-01-01

    By extending the recently developed generalized Courant-Snyder theory for coupled transverse beam dynamics, we have constructed the Gaussian beam distribution and its projections with arbitrary mode emittance ratios. The new formulation has been applied to a continuously-rotating quadrupole focusing channel because the basic properties of this channel are known theoretically and could also be investigated experimentally in a compact setup such as the linear Paul trap configuration. The new formulation retains a remarkably similar mathematical structure to the original Courant-Snyder theory, and thus provides a powerful theoretical tool to investigate coupled transverse beam dynamics in general and more complex linear focusing channels.

  16. Opposing Shear-Induced Forces Dominate Inertial Focusing in Curved Channels and High Reynolds Numbers

    CERN Document Server

    Keinan, Eliezer; Nahmias, Yaakov

    2015-01-01

    Inertial focusing is the migration of particles in fluid toward equilibrium, where current theory predicts that shear-induced and wall-induced lift forces are balanced. First reported in 1961, this Segre-Silberberg effect is particularly useful for microfluidic isolation of cells and particles. Interestingly, recent work demonstrated particle focusing at high Reynolds numbers that cannot be explained by current theory. In this work, we show that non-monotonous velocity profiles, such as those developed in curved channels, create peripheral velocity maxima around which opposing shear-induced forces dominate over wall effects. Similarly, entry effects amplified in high Reynolds flow produce an equivalent trapping mechanism in short, straight channels. This new focusing mechanism in the developing flow regime enables a 10-fold miniaturization of inertial focusing devices, while our model corrects long-standing misconceptions about the nature of mechanical forces governing inertial focusing in curved channels.

  17. On the Ergodic Capacity of Dual-Branch Correlated Log-Normal Fading Channels with Applications

    KAUST Repository

    Al-Quwaiee, Hessa

    2015-05-01

    Closed-form expressions of the ergodic capacity of independent or correlated diversity branches over Log-Normal fading channels are not available in the literature. Thus, it is become of an interest to investigate the behavior of such metric at high signal-to-noise (SNR). In this work, we propose simple closed-form asymptotic expressions of the ergodic capacity of dual-branch correlated Log- Normal corresponding to selection combining, and switch-and-stay combining. Furthermore, we capitalize on these new results to find new asymptotic ergodic capacity of correlated dual- branch free-space optical communication system under the impact of pointing error with both heterodyne and intensity modulation/direct detection. © 2015 IEEE.

  18. Exploiting Multi-user Diversity and Multi-hop Diversity in Dual-hop Broadcast Channels

    KAUST Repository

    Zafar, Ammar

    2013-05-21

    We propose joint user-and-hop scheduling over dual-hop block-fading broadcast channels in order to exploit multi-user diversity gains and multi-hop diversity gains all together. To achieve this objective, the first and second hops are scheduled opportunistically based on the channel state information. The joint scheduling problem is formulated as maximizing the weighted sum of the long term achievable rates of the users under a stability constraint, which means that in the long term the rate received by the relay should equal the rate transmitted by it, in addition to power constraints. We show that this problem is equivalent to a single-hop broadcast channel by treating the source as a virtual user with an optimal weight that maintains the stability constraint. We show how to obtain the source weight either off-line based on channel statistics or on real-time based on channel measurements. Furthermore, we consider special cases including the maximum sum-rate scheduler and the proportional fair scheduler. We also show how to extend the scheme into one that allows multiple user scheduling via superposition coding with successive decoding. Numerical results demonstrate that our proposed joint scheduling scheme enlarges the rate region as compared to scheduling schemes that exploit the diversity gains partially.

  19. A New Dual-electrode and Multi-channel Electrochemical DetectionSystem for Capillary Electrophoresis

    Institute of Scientific and Technical Information of China (English)

    Bing Yi YANG; Jin Yuan MO; Rong LAI

    2004-01-01

    A new type of dual-electrode and multi-channel electrochemical detection technology for capillary electrophoresis is described in this paper. Two detectors(the amperometric detector and the conductometric detector)or two conductometric detectors are connected to the same capillary electrophoresis system. The whole system possesses the advantages of the two electrochemical detectors including sparing time,improving the analytical speed and expanding the sample range.The working electrode and detector cell are handled easily.The system was applied to sample detection with satisfactory results.

  20. Recording spatially incoherent Fourier hologram using dual channel rotational shearing interferometer.

    Science.gov (United States)

    Watanabe, Kaho; Nomura, Takanori

    2015-01-01

    The method to record an incoherent Fourier hologram is proposed. The interference patterns in the dual channel rotational shearing interferometer are obtained as the figure of the cosine and the sine transformation in the vertical and the horizontal polarization, respectively. The proposed optical system is simple without spatial light modulators or mechanical phase shifting devices. The experiment, in which the letter "A" displayed on a liquid crystal display with a blue LED backlight was used as an object, confirms the proposed method to obtain an incoherent Fourier hologram.

  1. Elasto-inertial particle focusing under the viscoelastic flow of DNA solution in a square channel.

    Science.gov (United States)

    Kim, Bookun; Kim, Ju Min

    2016-03-01

    Particle focusing is an essential step in a wide range of applications such as cell counting and sorting. Recently, viscoelastic particle focusing, which exploits the spatially non-uniform viscoelastic properties of a polymer solution under Poiseuille flow, has attracted much attention because the particles are focused along the channel centerline without any external force. Lateral particle migration in polymer solutions in square channels has been studied due to its practical importance in lab-on-a-chip applications. However, there are still many questions about how the rheological properties of the medium alter the equilibrium particle positions and about the flow rate ranges for particle focusing. In this study, we investigated lateral particle migration in a viscoelastic flow of DNA solution in a square microchannel. The elastic property is relevant due to the long relaxation time of a DNA molecule, even when the DNA concentration is extremely low. Further, the shear viscosity of the solution is essentially constant irrespective of shear rate. Our current results demonstrate that the particles migrate toward the channel centerline and the four corners of a square channel in the dilute DNA solution when the inertia is negligible (elasticity-dominant flow). As the flow rate increases, the multiple equilibrium particle positions are reduced to a single file along the channel centerline, due to the elasto-inertial particle focusing mechanism. The current results support that elasto-inertial particle focusing mechanism is a universal phenomenon in a viscoelastic fluid with constant shear viscosity (Boger fluid). Also, the effective flow rate ranges for three-dimensional particle focusing in the DNA solution were significantly higher and wider than those for the previous synthetic polymer solution case, which facilitates high throughput analysis of particulate systems. In addition, we demonstrated that the DNA solution can be applied to focus a wide range of

  2. Dual focused coherent beams for three-dimensional optical trapping and continuous rotation of metallic nanostructures

    Science.gov (United States)

    Xu, Xiaohao; Cheng, Chang; Zhang, Yao; Lei, Hongxiang; Li, Baojun

    2016-07-01

    Metallic nanoparticles and nanowires are extremely important for nanoscience and nanotechnology. Techniques to optically trap and rotate metallic nanostructures can enable their potential applications. However, because of the destabilizing effects of optical radiation pressure, the optical trapping of large metallic particles in three dimensions is challenging. Additionally, the photothermal issues associated with optical rotation of metallic nanowires have far prevented their practical applications. Here, we utilize dual focused coherent beams to realize three-dimensional (3D) optical trapping of large silver particles. Continuous rotation of silver nanowires with frequencies measured in several hertz is also demonstrated based on interference-induced optical vortices with very low local light intensity. The experiments are interpreted by numerical simulations and calculations.

  3. A single channel input virtual dual-phase lock-in amplifier

    Science.gov (United States)

    Gao, Zhongjian; Zheng, Hua; Li, Lianhuang; Chen, Fang; Guo, Fuyuan

    2011-11-01

    In this article, it presents a suit of single channel input virtual Dual-Phase Lock-in Amplifier (DPLIA) that is constructed by a personal computer sound card and the LabVIEW software. The virtual DPLIA is low cost and convenient to implement. The implemented DPLIA could enhance the noise tolerance capability and lower the LOD of the optical signal detection system. A primary benefit of this instrument is it only needs one input channel; two internal reference signals of the digital PLL are generated in the LabVIEW software. It is easy to control and operate, the data processing results can be saved directly to disks. This instrument will be applied in other weak signal detection systems.

  4. Dual-channel in-line digital holographic double random phase encryption.

    Science.gov (United States)

    Das, Bhargab; Yelleswarapu, Chandra S; Rao, D V G L N

    2012-10-01

    We present a robust encryption method for the encoding of 2D/3D objects using digital holography and virtual optics. Using our recently developed dual-plane in-line digital holography technique, two in-line digital holograms are recorded at two different planes and are encrypted using two different double random phase encryption configurations, independently. The process of using two mutually exclusive encryption channels makes the system more robust against attacks since both the channels should be decrypted accurately in order to get a recognizable reconstruction. Results show that the reconstructed object is unrecognizable even when the portion of the correct phase keys used during decryption is close to 75%. The system is verified against blind decryptions by evaluating the SNR and MSE. Validation of the proposed method and sensitivities of the associated parameters are quantitatively analyzed and illustrated.

  5. Recent advances in therapeutic strategies that focus on the regulation of ion channel expression.

    Science.gov (United States)

    Ohya, Susumu; Kito, Hiroaki; Hatano, Noriyuki; Muraki, Katsuhiko

    2016-04-01

    A number of different ion channel types are involved in cell signaling networks, and homeostatic regulatory mechanisms contribute to the control of ion channel expression. Profiling of global gene expression using microarray technology has recently provided novel insights into the molecular mechanisms underlying the homeostatic and pathological control of ion channel expression. It has demonstrated that the dysregulation of ion channel expression is associated with the pathogenesis of neural, cardiovascular, and immune diseases as well as cancers. In addition to the transcriptional, translational, and post-translational regulation of ion channels, potentially important evidence on the mechanisms controlling ion channel expression has recently been accumulated. The regulation of alternative pre-mRNA splicing is therefore a novel therapeutic strategy for the treatment of dominant-negative splicing disorders. Epigenetic modification plays a key role in various pathological conditions through the regulation of pluripotency genes. Inhibitors of pre-mRNA splicing and histone deacetyalase/methyltransferase have potential as potent therapeutic drugs for cancers and autoimmune and inflammatory diseases. Moreover, membrane-anchoring proteins, lysosomal and proteasomal degradation-related molecules, auxiliary subunits, and pharmacological agents alter the protein folding, membrane trafficking, and post-translational modifications of ion channels, and are linked to expression-defect channelopathies. In this review, we focused on recent insights into the transcriptional, spliceosomal, epigenetic, and proteasomal regulation of ion channel expression: Ca(2+) channels (TRPC/TRPV/TRPM/TRPA/Orai), K(+) channels (voltage-gated, KV/Ca(2+)-activated, KCa/two-pore domain, K2P/inward-rectifier, Kir), and Ca(2+)-activated Cl(-) channels (TMEM16A/TMEM16B). Furthermore, this review highlights expression of these ion channels in expression-defect channelopathies.

  6. Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.

    Science.gov (United States)

    Li, Minghui; Zhang, Wei K; Benvin, Nicole M; Zhou, Xiaoyuan; Su, Deyuan; Li, Huan; Wang, Shu; Michailidis, Ioannis E; Tong, Liang; Li, Xueming; Yang, Jian

    2017-01-23

    The activities of organellar ion channels are often regulated by Ca(2+) and H(+), which are present in high concentrations in many organelles. Here we report a structural element critical for dual Ca(2+)/pH regulation of TRPML1, a Ca(2+)-release channel crucial for endolysosomal function. TRPML1 mutations cause mucolipidosis type IV (MLIV), a severe lysosomal storage disorder characterized by neurodegeneration, mental retardation and blindness. We obtained crystal structures of the 213-residue luminal domain of human TRPML1 containing three missense MLIV-causing mutations. This domain forms a tetramer with a highly electronegative central pore formed by a novel luminal pore loop. Cysteine cross-linking and cryo-EM analyses confirmed that this architecture occurs in the full-length channel. Structure-function studies demonstrated that Ca(2+) and H(+) interact with the luminal pore and exert physiologically important regulation. The MLIV-causing mutations disrupt the luminal-domain structure and cause TRPML1 mislocalization. Our study reveals the structural underpinnings of TRPML1's regulation, assembly and pathogenesis.

  7. Results of Buoyancy-gravity Effects in ITER Cable-in- Conduit Conductor with Dual Channel

    Science.gov (United States)

    Bruzzone, P.; Stepanov, B.; Zanino, R.; Richard, L. Savoldi

    2006-04-01

    The coolant in the ITER cable-in-conduit conductors (CICC) flows at significant higher speed in the central channel than in the strand bundle region due to the large difference of hydraulic impedance. When energy is deposited in the bundle region, e.g. by ac loss or radiation, the heat removal in vertically oriented dual channel CICC with the coolant flowing downward is affected by the reduced density of helium (buoyancy) in the bundle region, which is arising from the temperature gradient due to poor heat exchange between the two channels. At large deposited power, flow stagnation and back-flow can cause in the strand bundle area a slow temperature runaway eventually leading to quench. A new test campaign of the thermal-hydraulic behavior was carried out in the SULTAN facility on an instrumented section of the ITER Poloidal Field Conductor Insert (PFIS). The buoyancy-gravity effect was investigated using ac loss heating, with ac loss in the cable calibrated in separate runs. The extent of upstream temperature increase was explored over a broad range of mass flow rate and deposited power. The experimental behavior is partly reproduced by numerical simulations. The results from the tests are extrapolated to the likely operating conditions of the ITER Toroidal Field conductor with the inboard leg cooled from top to bottom and heat deposited by nuclear radiation from the burning plasma.

  8. Focused ion beam nano-structuring of Bragg gratings in $Al_2O_3$ channel waveguides

    NARCIS (Netherlands)

    Ay, Feridun; Uranga, Amaia; Bradley, Jonathan D.B.; Wörhoff, Kerstin; Ridder, de René M.; Pollnau, Markus; Ridder, de R.M.; Ay, F.; Kauppinen, L.J.

    2008-01-01

    We report our recent results on an optimization study of focused ion beam (FIB) nano-structuring of Bragg gratings in $Al_2O_3$ channel waveguides. By optimizing FIB milling parameters such as ion current, dwell time, loop repetitions, scanning strategy, and applying a top metal layer for reducing c

  9. Dual-channel functional electrical stimulation improvements in speed-based gait classifications

    Directory of Open Access Journals (Sweden)

    Springer S

    2013-02-01

    Full Text Available Shmuel Springer,1,2 Yocheved Laufer,1 Meni Becher,1,2 Jean-Jacques Vatine3,41Department of Physical Therapy, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, 2Clinical Department, Bioness Neuromodulation, Ra'anana, 3Outpatient and Research Division, Reuth Medical Center, Tel Aviv, 4Department of Rehabilitation Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, IsraelBackground: Functional electrical stimulation (FES is becoming an accepted treatment method for enhancing gait performance in patients who present with gait difficulties resulting from hemiparesis. The purpose of this study was to test whether individuals with hemiparesis who have varied gait speeds, which place them in different functional categories, benefit to the same extent from the application of FES.Methods: Thirty-six subjects with chronic hemiparesis demonstrating foot-drop and deficits in knee and/or hip control were fitted with a dual-channel FES system activating the dorsiflexors and hamstring muscles. Gait was assessed during a 2-minute walk test with and without stimulation. A second assessment was conducted after 6 weeks of daily use. Analysis was performed with the subjects stratified into three functional ambulation classes according to their initial gait categories.Results: The dual-channel FES improved the gait velocity of all three subgroups. No minimal gait velocity was required in order to gain benefits from FES. For example, subjects with limited household ambulation capabilities improved their gait speed by 63.3% (from 0.30 ± 0.09 m/sec to 0.49 ± 0.20 m/sec; P < 0.01, while subjects with functional community ambulation capabilities improved their gait speed by 25.5% (from 0.90 ± 0.11 m/sec to 1.13 ± 0.22 m/sec; P < 0.01.Conclusion: Dual-channel FES positively affects gait velocity in patients with chronic hemiparesis, regardless of their initial gait velocity. Furthermore, gait velocity gains may be large enough

  10. 2-μm switchable dual-wavelength fiber laser with cascaded filter structure based on dual-channel Mach-Zehnder interferometer and spatial mode beating effect

    Science.gov (United States)

    Wang, Shun; Lu, Ping; Zhao, Shui; Liu, Deming; Yang, Wei; Zhang, Jiangshan

    2014-06-01

    We demonstrated a 2-μm switchable dual-wavelength fiber laser with cascaded filter structure based on dual-channel Mach-Zehnder interferometer and spatial mode beating effect. Few-mode fiber-embedded Sagnac ring configuration and a Mach-Zehnder interferometer are cascaded to form a multiwavelength filter for our previous 2-μm fiber laser. By adopting suitable fiber length and adjusting the polarization controller, we obtained a 2-μm dual-wavelength fiber laser with switchable wavelength interval. Experimental results revealed that the proposed laser shows higher quality and better stability compared with our previous work and it has potential applications in the fields of atmospheric propagation and microwave photonics.

  11. Rational design, synthesis of reaction-based dual-channel cyanide sensor in aqueous solution

    Science.gov (United States)

    Li, Jun-Jian; Wei, Wei; Qi, Xiao-Liang; Xu, Xiao; Liu, Yu-Cheng; Lin, Qiu-Han; Dong, Wei

    2016-01-01

    A new dual-channel sensor for the detection of cyanide was developed based on the conjugated of naphthalene and malononitrile. Upon the addition of CN-, the sensor displayed very large blue-shift in both fluorescence (80 nm) and absorption (120 nm) spectra. The sensor of cyanide was performed via the nucleophilic attack of cyanide anion to vinylic groups of the sensor with a 1:1 binding stoichiometry and the color changed of the sensor is mainly due to the intramolecular charge transfer process improvement. The intramolecular charge transfer progress was blocked with color changed and fluorescence blue-shift. The mechanism of sensor reaction with CN- ion was studied using 1H NMR and mass spectrometry.

  12. Complexity analysis of dual-channel game model with different managers' business objectives

    Science.gov (United States)

    Li, Ting; Ma, Junhai

    2015-01-01

    This paper considers dual-channel game model with bounded rationality, using the theory of bifurcations of dynamical system. The business objectives of retailers are assumed to be different, which is closer to reality than previous studies. We study the local stable region of Nash equilibrium point and find that business objectives can expand the stable region and play an important role in price strategy. One interesting finding is that a fiercer competition tends to stabilize the Nash equilibrium. Simulation shows the complex behavior of two dimensional dynamic system, we find period doubling bifurcation and chaos phenomenon. We measure performances of the model in different period by using the index of average profit. The results show that unstable behavior in economic system is often an unfavorable outcome. So this paper discusses the application of adaptive adjustment mechanism when the model exhibits chaotic behavior and then allows the retailers to eliminate the negative effects.

  13. Optical image hiding based on dual-channel simultaneous phase-shifting interferometry and compressive sensing

    Science.gov (United States)

    Li, Jiaosheng; Zhong, Liyun; Zhang, Qinnan; Zhou, Yunfei; Xiong, Jiaxiang; Tian, Jindong; Lu, Xiaoxu

    2017-01-01

    We propose an optical image hiding method based on dual-channel simultaneous phase-shifting interferometry (DCSPSI) and compressive sensing (CS) in all-optical domain. In the DCSPSI architecture, a secret image is firstly embedded in the host image without destroying the original host's form, and a pair of interferograms with the phase shifts of π/2 is simultaneously generated by the polarization components and captured by two CCDs. Then, the holograms are further compressed sampling to the less data by CS. The proposed strategy will provide a useful solution for the real-time optical image security transmission and largely reducing data volume of interferogram. The experimental result demonstrates the validity and feasibility of the proposed method.

  14. Processing of low Carbon steel by dual rolls equal channel extrusion

    Science.gov (United States)

    Rusz, S.; Cizek, L.; Salajka, M.; Kedron, J.; Tylsar, S.

    2014-08-01

    This paper introduces a new method of forming for achievement of grain structure refinement by processing in DRECE (Dual Rolls Equal Channel Extrusion) equipment. The DRECE device was developed at the VSB - Technical University of Ostrava. It allows grain refinement in strip plate with dimensions of 58 mm (width) × 2 mm (thickness) × 1000 mm (length). The influence of the number of passes on the mechanical properties and related structure refinement was examined experimentally. The effect of a heat treatment (500 °C/1 h/steady air) on the grain refinement of low carbon steel after severe plastic deformation is analysed. Through this novel technique, the grain structure can be converted into a submicron grain structure.

  15. The Impact of Price Comparison Service on Pricing Strategy in a Dual-Channel Supply Chain

    Directory of Open Access Journals (Sweden)

    Qi Xu

    2013-01-01

    Full Text Available Recently, price comparison service (PCS websites are more and more popular due to its features in facilitating transparent price and promoting rational purchase decision. Motivated by the industrial practices, in this study, we examine the pricing strategies of retailers and supplier in a dual-channel supply chain influenced by the signals of PCS. We categorize and discuss three situations according to the signal availability of PCS, under which the optimal pricing strategies are derived. Finally, we conduct a numerical study and find that in fact the retailers and supplier are all more willing to avoid the existence of PCS with the objective of profit maximization. When both of retailers are affected by the PCS, the supplier is more willing to reduce the availability of price information. Important managerial insights are discussed.

  16. Stability and quench of dual cooling channel cable-in-conduct superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Blau, Bertrand [Ecole Polytechnique Federale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), CH-1015 Lausanne (Switzerland)

    1999-11-01

    Presently, the most ambitious experimental project towards controlled thermonuclear fusion is the International Thermonuclear Experimental Reactor ITER. All coils of its magnet system will be superconducting since for magnetic fields in the range between 6 - 13 T high current densities are required. During recent years, in particular for fusion applications, a special configuration of superconductor was favoured: the so-called Cable-In-Conduit Conductor (CICC). The CICCs for ITER consist of a superconducting cable made of a large number of superconducting wires (NbTi or Nb{sub 3}Sn) twisted around a central cooling channel, which are tightly jacketed in a metal conduit, providing the desired mechanical stiffness of the conductor against magnetic forces. Pressurized supercritical helium is pumped through the cable interstices and the central channel. The direct contact between the coolant and the cable provides good thermal stability of the conductor against sudden energy inputs. These disturbances can lead to a transition into the normal state (quench) if the released energy is sufficiently high, so that the temperature of the superconductor exceeds locally its critical temperature and if the energy cannot be absorbed efficiently by the surrounding helium. Stability of superconductors against quenches is one of the most important issues in applied superconductivity. The recovery capabilities of a CICC after thermal disturbances are governed by the heat transfer rate from the strands to the helium. The heat transfer is greatly affected by the flow velocity of the coolant. It has been shown theoretically that a temporal thermal disturbance in a CICC can induce an additional strong helium flow, which enhances the heat transfer rate and, hence, the stability. This self-stabilizing effect is believed to play an important role for the recovery capabilities of a CICC. The scope of this thesis is the experimental assessment of the quench and stability behaviour of dual

  17. Applying Convolution-Based Processing Methods To A Dual-Channel, Large Array Artificial Olfactory Mucosa

    Science.gov (United States)

    Taylor, J. E.; Che Harun, F. K.; Covington, J. A.; Gardner, J. W.

    2009-05-01

    Our understanding of the human olfactory system, particularly with respect to the phenomenon of nasal chromatography, has led us to develop a new generation of novel odour-sensitive instruments (or electronic noses). This novel instrument is in need of new approaches to data processing so that the information rich signals can be fully exploited; here, we apply a novel time-series based technique for processing such data. The dual-channel, large array artificial olfactory mucosa consists of 3 arrays of 300 sensors each. The sensors are divided into 24 groups, with each group made from a particular type of polymer. The first array is connected to the other two arrays by a pair of retentive columns. One channel is coated with Carbowax 20 M, and the other with OV-1. This configuration partly mimics the nasal chromatography effect, and partly augments it by utilizing not only polar (mucus layer) but also non-polar (artificial) coatings. Such a device presents several challenges to multi-variate data processing: a large, redundant dataset, spatio-temporal output, and small sample space. By applying a novel convolution approach to this problem, it has been demonstrated that these problems can be overcome. The artificial mucosa signals have been classified using a probabilistic neural network and gave an accuracy of 85%. Even better results should be possible through the selection of other sensors with lower correlation.

  18. Study on Complex Advertising and Price Competition Dual-Channel Supply Chain Models Considering the Overconfidence Manufacturer

    Directory of Open Access Journals (Sweden)

    Junhai Ma

    2016-01-01

    Full Text Available In order to explore how the manufacturers make decisions when two manufacturers compete for local advertising investment, we examine two noncooperative models (Stackelberg and Nash game and propose a cost sharing contract to investigate channel competition of dual-channel supply chain. The dominant power between manufacturer and retailer and the effect of channel competition strategy on price are mainly discussed. In addition, dynamic system concepts are integrated into Stackelberg game model based on bounded rational mechanism. We analyze the local stability and find that the stability level of the dual-channel supply chains depends crucially on the price adjustment speed, the level of demand uncertainty, and the risk preference. The outcome shows that, under the master-slave game model, the profits of manufacturers are greater than that under decentralized decision-making mode, and the profits of retailers under master-slave game model are less than that under decentralized decision-making mode. The profits of manufacturers and retailers in the stable region are greater than that in unstable region. Finally, the delay feedback control method is utilized and effectively controls the chaotic behavior of dual-channel supply chain model. The results have theoretical and practical significance for the game models in terms of advertising and price competition.

  19. Analysis of Stierwalt out-of-band transmission scattering effect for dual infrared filters serially positioned at a focus

    Science.gov (United States)

    Kumer, J. B.; Sterrit, L. W.; Eisenhauer, D. L.

    1986-01-01

    Some remote sounding applications require utilization of interference filters with very high out-of-band rejection (OBR) performance. In this paper, the advantages to be gained in achieving high OBR by the use of two serially ganged interference filters mounted in a wedge configuration near a focus are discussed. Degradation of OBR due to scattering effects is examined, and a quantitative technique to estimate such effects in dual wedged filters mounted at a focus is presented. An approach to the design of filter elements to be used in the dual wedged configuration is given that accounts for scatter. An application of this design approach to the CLAES 10.81 micron filter is described.

  20. A 16-channel receive, forced current excitation dual-transmit coil for breast imaging at 7T.

    Directory of Open Access Journals (Sweden)

    Samantha By

    Full Text Available To enable high spatial and temporal breast imaging resolution via combined use of high field MRI, array coils, and forced current excitation (FCE multi channel transmit.A unilateral 16-channel receive array insert was designed for use in a transmit volume coil optimized for quadrature operation with dual-transmit RF shimming at 7 T. Signal-to-noise ratio (SNR maps, g-factor maps, and high spatial and temporal resolution in vivo images were acquired to demonstrate the utility of the coil architecture.The dual-transmit FCE coil provided homogeneous excitation and the array provided an increase in average SNR of 3.3 times (max 10.8, min 1.5 compared to the volume coil in transmit/receive mode. High resolution accelerated in vivo breast imaging demonstrated the ability to achieve isotropic spatial resolution of 0.5 mm within clinically relevant 90 s scan times, as well as the ability to perform 1.0 mm isotropic resolution imaging, 7 s per dynamics, with the use of bidirectional SENSE acceleration of up to R = 9.The FCE design of the transmit coil easily accommodates the addition of a sixteen channel array coil. The improved spatial and temporal resolution provided by the high-field array coil with FCE dual-channel transmit will ultimately be beneficial in lesion detection and characterization.

  1. Dual-Focus Mutual Aid for Co-occurring Disorders: A Quasi-Experimental Outcome Evaluation Study

    OpenAIRE

    Magura, Stephen; Rosenblum, Andrew; Villano, Cherie L.; Vogel, Howard S.; Fong, Chunki; Betzler, Thomas

    2008-01-01

    Previous observational research has indicated the effectiveness of a 12-step, dual-focus mutual aid group, Double Trouble in Recovery (DTR), for assisting individuals to recover from co-occurring substance use and psychiatric disorders. The current study extends this line of research by evaluating DTR with a quasi-experimental design; controlled designs are rare in studies of mutual aid. Patient outcomes in the same psychiatric day treatment program were compared for two consecutive admission...

  2. Suppression of Space Charge Induced Beam Halo in Nonlinear Focusing Channel

    CERN Document Server

    Batygin, Yuri K; Kurennoy, Sergey; Li, Chao

    2016-01-01

    An intense non-uniform particle beam exhibits strong emittance growth and halo formation in focusing channels due to nonlinear space charge forces of the beam. This phenomenon limits beam brightness and results in particle losses. The problem is connected with irreversible distortion of phase space volume of the beam in conventional focusing structures due to filamentation in phase space. Emittance growth is accompanied by halo formation in real space, which results in inevitable particle losses. A new approach for solving a self-consistent problem for a matched non-uniform beam in two-dimensional geometry is discussed. The resulting solution is applied to the problem of beam transport, while avoiding emittance growth and halo formation by the use of nonlinear focusing field. Conservation of a beam distribution function is demonstrated analytically and by particle-in-cell simulation for a beam with a realistic beam distribution.

  3. Suppression of space charge induced beam halo in nonlinear focusing channel

    Science.gov (United States)

    Batygin, Yuri K.; Scheinker, Alexander; Kurennoy, Sergey; Li, Chao

    2016-04-01

    An intense non-uniform particle beam exhibits strong emittance growth and halo formation in focusing channels due to nonlinear space charge forces of the beam. This phenomenon limits beam brightness and results in particle losses. The problem is connected with irreversible distortion of phase space volume of the beam in conventional focusing structures due to filamentation in phase space. Emittance growth is accompanied by halo formation in real space, which results in inevitable particle losses. A new approach for solving a self-consistent problem for a matched non-uniform beam in two-dimensional geometry is discussed. The resulting solution is applied to the problem of beam transport, while avoiding emittance growth and halo formation by the use of nonlinear focusing field. Conservation of a beam distribution function is demonstrated analytically and by particle-in-cell simulation for a beam with a realistic beam distribution.

  4. A Dual Approach to Fostering Under-Prepared Student Success: Focusing on Doing and Becoming

    Science.gov (United States)

    Shaffer, Suzanne C.; Eshbach, Barbara E.; Santiago-Blay, Jorge A.

    2015-01-01

    A paired course model for under-prepared college students incorporates a dual instructional approach, academic skill building and lifelong learning development, to help students do more academically and become stronger lifelong learners. In a reading support course, students improved their reading skills and applied them directly to the paired…

  5. Stability and quench of dual cooling channel cable-in-conduct superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Blau, Bertrand [Ecole Polytechnique Federale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), CH-1015 Lausanne (Switzerland)

    1999-11-01

    Presently, the most ambitious experimental project towards controlled thermonuclear fusion is the International Thermonuclear Experimental Reactor ITER. All coils of its magnet system will be superconducting since for magnetic fields in the range between 6 - 13 T high current densities are required. During recent years, in particular for fusion applications, a special configuration of superconductor was favoured: the so-called Cable-In-Conduit Conductor (CICC). The CICCs for ITER consist of a superconducting cable made of a large number of superconducting wires (NbTi or Nb{sub 3}Sn) twisted around a central cooling channel, which are tightly jacketed in a metal conduit, providing the desired mechanical stiffness of the conductor against magnetic forces. Pressurized supercritical helium is pumped through the cable interstices and the central channel. The direct contact between the coolant and the cable provides good thermal stability of the conductor against sudden energy inputs. These disturbances can lead to a transition into the normal state (quench) if the released energy is sufficiently high, so that the temperature of the superconductor exceeds locally its critical temperature and if the energy cannot be absorbed efficiently by the surrounding helium. Stability of superconductors against quenches is one of the most important issues in applied superconductivity. The recovery capabilities of a CICC after thermal disturbances are governed by the heat transfer rate from the strands to the helium. The heat transfer is greatly affected by the flow velocity of the coolant. It has been shown theoretically that a temporal thermal disturbance in a CICC can induce an additional strong helium flow, which enhances the heat transfer rate and, hence, the stability. This self-stabilizing effect is believed to play an important role for the recovery capabilities of a CICC. The scope of this thesis is the experimental assessment of the quench and stability behaviour of dual

  6. Numerical analysis of ultrafast physical random number generator using dual-channel optical chaos

    Science.gov (United States)

    Elsonbaty, Amr; Hegazy, Salem F.; Obayya, Salah S. A.

    2016-09-01

    Fast physical random number generators (PRNGs) are essential elements in the development of many modern applications. We numerically demonstrate an extraction scheme to establish an ultrafast PRNG using dual-channel optical-chaos source. Simultaneous suppression of time-delay signature in all observables of the output is verified using autocorrelation-function method. The proposed technique compares the level of the chaotic signal at time t with M levels of its delayed version. The comparators [1-bit analog-to-digital converters (ADCs)] are triggered using a clock subject to an incremental delay. All the delays of the chaotic signal before the ADCs and the relative delays of the clock are mutually incommensurable. The outputs of the ADCs are then combined using parity-check logic to produce physically true random numbers. The randomness quality of the generated random bits is evaluated by the statistical tests of National Institute of Standards and Technology Special Publication 800-22. The results verify that all tests are passed from M=1 to M=39 at sampling rate up to 34.5 GHz, which indicates that the maximum generation rate of random bits is 2.691 Tb/s without employing any preprocessing techniques. This rate, to the best of our knowledge, is higher than any previously reported PRNG.

  7. Dual-channel current valve in a three terminal zigzag graphene nanoribbon junction

    Science.gov (United States)

    Zhang, L.

    2017-02-01

    We theoretically propose a dual-channel current valve based on a three terminal zigzag graphene nanoribbon (ZGNR) junction driven by three asymmetric time-dependent pumping potentials. By means of the Keldysh Green’s function method, we show that two asymmetric charge currents can be pumped in the different left-right terminals of the device at a zero bias, which mainly stems from the single photon-assisted pumping approximation and the valley valve effect in a ZGNR p-n junction. The ON and OFF states of pumped charge currents are crucially dependent on the even-odd chain widths of the three electrodes, the pumping frequency, the lattice potential and the Fermi level. Two-tunneling spin valves are also considered to spatially separate and detect 100% polarized spin currents owing to the combined spin pump effect and the valley selective transport in a three terminal ZGNR ferromagnetic junction. Our investigations might be helpful to control the spatial and spin degrees of freedom of electrons in graphene pumping devices.

  8. A dual-channel flux-switching permanent magnet motor for hybrid electric vehicles

    Science.gov (United States)

    Hua, Wei; Wu, Zhongze; Cheng, Ming; Wang, Baoan; Zhang, Jianzhong; Zhou, Shigui

    2012-04-01

    The flux-switching permanent magnet (FSPM) motor is a relatively novel brushless machine having both magnets and concentrated windings in the stator, which exhibits inherently sinusoidal PM flux-linkage, back-EMF waveforms, and high torque capability. However, in the application of hybrid electric vehicles, it is essential to prevent magnets and armature windings moving in radial direction due to the possible vibration during operation, and to ensure fault-tolerant capability. Hence, in this paper based on an original FSPM motor, a dual-channel FSPM (DC-FSPM) motor with modified structure to fix both armature windings and magnets and improved reliability is proposed for a practical 10 kW integral starter/generator (ISG) in hybrid electric vehicles. The influences of different solutions and the end-effect on the static characteristics, are evaluated based on the 2D and 3D finite element analysis, respectively. Finally, both the predicted and experimental results, compared with a prototype DC-FSPM motor and an interior PM motor used in Honda Civic, confirm that the more sinusoidal back-EMF waveform and lower torque ripple can be achieved in the DC-FSPM motor, whereas the torque is smaller under the same coil current.

  9. Closed-Form Performance Analysis of Dual Polarization Based MIMO System in Shadowed-Rician Fading LMS Channels

    Directory of Open Access Journals (Sweden)

    Suresh Kumar Jindal

    2015-04-01

    Full Text Available In this paper, the problem of dual polarization based MIMO Processing in Shadowed-Rician (SR fading land mobile satellite (LMS channels is studied. It is shown in literature that polarization is used as a interference rejection method; and, most of the existing analytical results are not in closed-form. In this paper, we derive the closed-form expressions of the moment generating (MGF function of the received signal-to-noise ratio of the MRC based receiver in SR fading LMS channels. Then we provide closed-form expressions of the symbol error rate (SER by using MGF approach. The analytical diversity order and capacity of the considered scheme is also derived. It is shown by by derived closed-form capacity expression that the capacity of the considered dual polarization based scheme is improved; and it is found very useful in practical satellite communication systems.

  10. Optimization of nanoparticle focusing by coupling thermophoresis and engineered vortex in a microfluidic channel

    Science.gov (United States)

    Zhao, Chao; Cao, Zhibo; Fraser, John; Oztekin, Alparslan; Cheng, Xuanhong

    2017-01-01

    Enriching nanoparticles in an aqueous solution is commonly practiced for various applications. Despite recent advances in microfluidic technologies, a general method to concentrate nanoparticles in a microfluidic channel in a label free and continuous flow fashion is not yet available, due to strong Brownian motion on the nanoscale. Recent research of thermophoresis indicates that thermophoretic force can overcome the Brownian force to direct nanoparticle movement. Coupling thermophoresis with natural convection on the microscale has been shown to induce significant enrichment of biomolecules in a thermal diffusion column. However, the column operates in a batch process, and the concentrated samples are inconvenient to retrieve. We have recently designed a microfluidic device that combines a helical fluid motion and simple one-dimensional temperature gradient to achieve effective nanoparticle focusing in a continuous flow. The helical convection is introduced by microgrooves patterned on the channel floor, which directly controls the focusing speed and power. Here, COMSOL simulations are conducted to study how the device geometry and flow rate influence transport and subsequent nanoparticle focusing, with a constant temperature gradient. The results demonstrate a complex dependence of nanoparticle accumulation on the microgroove tilting angle, depth, and spacing, as well as channel width and flow rate. Further dimensional analyses reveal that the ratio between particle velocities induced by thermophoretic and fluid inertial forces governs the particle concentration factor, with a maximum concentration at a ratio of approximately one. This simple relationship provides fundamental insights about nanoparticle transport in coupled flow and thermal fields. The study also offers a useful guideline to the design and operation of nanoparticle concentrators based on combining engineered helical fluid motion subject to phoretic fields.

  11. Quantum Interference of Dual-Channel Excited Magnons in Spin-1 Bose—Einstein Condensates Atomic Chain

    Science.gov (United States)

    Zhao, Xu; Zhao, Xing-Dong; Zhou, Lu; Jing, Hui; Zhang, Wei-Ping

    2013-07-01

    We investigate the quantum interference of spin wave excitations of a spin-1 atomic Bose condensate confined in an optical lattice. Single-channel and dual-channel interactions are employed in our system, and their induced excitations are compared. Also we consider the interplay of magneto-optical excitations, which leads to a constructive or destructive effect for the creation of magnons based on background excitations. The population distributions of excited magnons can be well controlled by steering the long-range dipole-dipole interactions. Such a scheme can be used to demonstrate conventional quantum-optical phenomena like dynamical Casimir effect at finite temperatures.

  12. Quantum Interference of Dual-Channel Excited Magnons in Spin-1 Bose-Einstein Condensates Atomic Chain

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xu; ZHAO Xing-Dong; ZHOU Lu; JING Hui; ZHANG Wei-Ping

    2013-01-01

    We investigate the quantum interference of spin wave excitations of a spin-1 atomic Bose condensate confined in an optical lattice.Single-channel and dual-channel interactions are employed in our system,and their induced excitations are compared.Also we consider the interplay of magneto-optical excitations,which leads to a constructive or destructive effect for the creation of magnons based on background excitations.The population distributions of excited magnons can be well controlled by steering the long-range dipole-dipole interactions.Such a scheme can be used to demonstrate conventional quantum-optical phenomena like dynamical Casimir effect at finite temperatures.

  13. A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule.

    Science.gov (United States)

    Ma, Long; Liu, Haiyan; Wu, Guanrong; Sun, Nana; Meng, Lingpei; Li, Yuyin; Liu, Zhenxing; Diao, Aipo

    2016-06-20

    We have constructed a 'turn-off' and label free bio-sensor using a DNAzyme molecule. This facile bio-sensor is capable of selective detection of mercuric ions with a high sensitivity and satisfactory dynamic range. More importantly, it is able to generate both fluorescent and colourimetric signals for detection. This dual-channel bio-sensor is expected to afford high detection confidence and overcome false-positive readout especially when assaying complex biological samples.

  14. Applications of focused MeV light ion beams for high resolution channeling contrast imaging

    Energy Technology Data Exchange (ETDEWEB)

    Jamieson, D.N.; Breese, M.B.H.; Prawer, S.; Dooley, S.P.; Allen, M.G.; Bettiol, A.A.; Saint, A. [Melbourne Univ., Parkville, VIC (Australia). School of Physics; Ryan, C.G. [Commonwealth Scientific and Industrial Research Organisation (CSIRO), North Ryde, NSW (Australia). Div. of Exploration Geoscience

    1993-12-31

    The technique of Nuclear Microscopy, utilizing a focused ion probe of typically MeV H{sup +} or He{sup +} ions, can produce images where the contrast depends on typical Ion Beam Analysis (lBA) processes. The probe forming lens system usually utilizes strong focusing, precision magnetic quadrupole lenses and the probe is scanned over the target to produce images. Originally, this imaging technique was developed to utilize backscattered particles with incident beam currents typically of a few nA, and the technique became known as Channeling Contrast Microscopy (CCM). Recently, the technique has been developed further to utilize the forward scattering of ions incident along a major crystal axis in thin crystals. This technique is known as Channeling Scanning Transmission Ion Microscopy (CSTIM). Since nearly all incident ions are detected, CSTIM is highly efficient and very low beam currents are sufficient for imaging, typically as low as a few fA. This allows probes as small as 50 nm to be used. In this paper we briefly review the recent applications of these emerging techniques to a variety of single crystal materials (authors). 13 refs., 5 figs.

  15. Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.

    Science.gov (United States)

    Kuo, Ivana Y; Hu, Jian; Ha, Ya; Ehrlich, Barbara E

    2015-03-06

    The GxGD proteases function to cleave protein substrates within the membrane. As these proteases contain multiple transmembrane domains typical of ion channels, we examined if GxGD proteases also function as ion channels. We tested the putative dual function by examining two archeobacterial GxGD proteases (PSH and FlaK), with known three-dimensional structures. Both are in the same GxGD family as presenilin, a protein mutated in Alzheimer Disease. Here, we demonstrate that PSH and FlaK form cation channels in lipid bilayers. A mutation that affected the enzymatic activity of FlaK rendered the channel catalytically inactive and altered the ion selectivity, indicating that the ion channel and the catalytic activities are linked. We report that the GxGD proteases, PSH and FlaK, are true "chanzymes" with interdependent ion channel and protease activity conferred by a single structural domain embedded in the membrane, supporting the proposal that higher-order proteases, including presenilin, have channel function.

  16. Design of a superconducting beam transport channel and beam dynamics for a strong-focusing cyclotron

    Science.gov (United States)

    Badgley, Karie Elizabeth

    There is an increasing interest in high power proton accelerators for use as neutron and muon sources, accelerator driven systems (ADS) for nuclear waste transmutation, high energy physics, medical physics, nuclear physics, and medical isotope production. Accelerating high current beams has a number of challenges; including avoiding harmful resonance crossing, space charge effects and, specific to cyclotrons, sufficient turn separation at injection and extraction. The Accelerator Research Laboratory at Texas A&M University is developing a high-power strong-focusing cyclotron with two main technologies to overcome these challenges. The first is a superconducting RF cavity to provide the energy gain required for fully separated turns. The second is the use of superconducting beam transport channels within the sectors of the cyclotron to provide strong-focusing with alternating focusing and defocusing quadrupoles. A method has been developed to find the equilibrium spiral orbit through the cyclotron which maintains isochronicity. The isochronous spiral orbit was then used to perform full linear optics calculations. The strengths of the quadrupoles were adjusted to hold the horizontal and vertical betatron tunes constant per turn to avoid resonance crossing. Particle tracking was performed with a modified MAD-X-PTC code and Synergia to provide a framework for future space charge studies. Magnetic modeling was performed on a 2D cross section of the beam transport channel. The wire locations were adjusted to reduce the higher order multipoles and a good field region was obtained at 70% of the beam pipe aperture with multipoles less than 10-4 . The 2D model was also used to determine the required current density needed to produce the quadrupole gradients. MgB2 superconducting wire was chosen as it meets all the field and current requirements and can operate at a reduced cryogenic cost. A winding mandrel was also designed and fabricated which minimized the bend radius for

  17. A Dual Approach to Fostering Under-Prepared Student Success: Focusing on Doing and Becoming

    Directory of Open Access Journals (Sweden)

    Suzanne C. Shaffer, MsEd, MEd

    2015-08-01

    Full Text Available A paired course model for under-prepared college students incorporates a dual instructional approach, academic skill building and lifelong learning development, to help students do more academically and become stronger lifelong learners. In a reading support course, students improved their reading skills and applied them directly to the paired content course. They also developed lifelong learning attributes through increased self-knowledge (using the Effective Lifelong Learning Inventory, reflection, and coaching. Students showed significant gains in lifelong learning, an 85% success rate in the paired content course, and a higher retention rate than students outside the project with similar SAT critical reading scores.

  18. Immediate Survival Focus: Synthesizing Life History Theory and Dual Process Models to Explain Substance Use

    Directory of Open Access Journals (Sweden)

    George B. Richardson

    2012-10-01

    Full Text Available Researchers have recently applied evolutionary life history theory to the understanding of behaviors often conceived of as prosocial or antisocial. In addition, researchers have applied cognitive science to the understanding of substance use and used dual process models, where explicit cognitive processes are modeled as relatively distinct from implicit cognitive processes, to explain and predict substance use behaviors. In this paper we synthesized these two theoretical perspectives to produce an adaptive and cognitive framework for explaining substance use. We contend that this framework provides new insights into the nature of substance use that may be valuable for both clinicians and researchers.

  19. Design of a dual-channel multi-mode GNSS receiver with a Σ △ fractional-N synthesizer

    Institute of Scientific and Technical Information of China (English)

    Long Qiang; Zhuang Yiqi; Yin Yue; Li Le; Wang Jin; Li Zhenrong; Liu Qiankun; Wang Lei

    2012-01-01

    A 72 mW highly integrated dual-channel multimode GNSS (global navigation satellite system) receiver with a Σ △ fractional-N synthesizer which covers GPS L1 and the Compass B1/B2/B3 band is presented.This chip was fabricated in a TSMC CMOS 0.18 μm process and packaged in a 48-pin 3 × 3 mm2 land grid array chip scale package.This work achieves NF ≤ 5.3 dB without an external LNA,channel gain =105 dB for channel one (Compass B2 and B3 band),and channel gain =110 dB for channel two (GPS L1 and Compass B1 band).Image rejection (IMRR) =36 dB,phase noise is 115.9 dBc@1 MHz and-108.9 dBc@1 MHz offset from the carrier for the two channels separately.At the low power consumption,multibands of GNSS are compatible in one chip,which is easy for consumers to use,when two different navigation signals are received simultaneously.

  20. JPEG color barcode images analysis: A camera phone capture channel model with auto-focus

    Directory of Open Access Journals (Sweden)

    Keng T. Tan

    2009-12-01

    Full Text Available As camera phones have permeated into our everyday lives, two dimensional (2D barcode has attracted researchers and developers as a cost-effective ubiquitous computing tool. A variety of 2D barcodes and their applications have been developed. Often, only monochrome2D barcodes are used due to their robustness in an uncontrolled operating environment of camera phones. However, we are seeing an emerging use of color 2D barcodes for camera phones. Nonetheless, using a greater multitude of colors introduces errors that can negatively affect the robustness of barcode reading. This is especially true when developing a 2D barcode for camera phones which capture and store these barcode images in the baselineJPEG format. This paper presents one aspect of the errors introduced by such camera phones by modeling the camera phone capture channel for JPEG color barcode images wherein there is camera auto-focus.

  1. Different Designs of Dual-Focus Perforated Transmitarray Antenna in Near/Far-Field Region

    Directory of Open Access Journals (Sweden)

    H. Abd El-Azem Malhat

    2016-01-01

    Full Text Available Designs of the single-focus and multi-focused transmitarray antennas for the near-field (NF or/and far-field (FF applications have been introduced. Perforated dielectric single sheet is used for transmitarray design for simple configuration. Single-focus transmitarray for the far-field and the near-field are obtained. The radiation characteristics of 13×13 unit-cells transmitarray in the near-field and the far-field region have been investigated. A single structure multi-focus transmitarray is designed using the chess-board arrangement of the unit-cells elements. Multi-focus transmitarray for FF/FF, FF/NF, and NF/NF have been designed and investigated. The phase distribution and the corresponding holes radii for the first quadrant of the multi-focus transmitarray are presented. The radiation characteristics of different array configuration have been investigated and analyzed using full-wave simulator CST Microwave Studio.

  2. Neuroprotection in the treatment of glaucoma--A focus on connexin43 gap junction channel blockers.

    Science.gov (United States)

    Chen, Ying-Shan; Green, Colin R; Danesh-Meyer, Helen V; Rupenthal, Ilva D

    2015-09-01

    Glaucoma is a form of optic neuropathy and a common cause of blindness, affecting over 60 million people worldwide with an expected rise to 80 million by 2020. Successful treatment is challenging due to the various causes of glaucoma, undetectable symptoms at an early stage and inefficient delivery of drugs to the back of the eye. Conventional glaucoma treatments focus on the reduction of elevated intraocular pressure (IOP) using topical eye drops. However, their efficacy is limited to patients who suffer from high IOP glaucoma and do not address the underlying susceptibility of retinal ganglion cells (RGC) to degeneration. Glaucoma is known as a neurodegenerative disease which starts with RGC death and eventually results in damage of the optic nerve. Neuroprotective strategies therefore offer a novel treatment option for glaucoma by not only preventing neuronal loss but also disease progression. This review firstly gives an overview of the pathophysiology of glaucoma as well as current treatment options including conventional and novel delivery strategies. It then summarizes the rational for neuroprotection as a novel therapy for glaucomatous neuropathies and reviews current potential neuroprotective strategies to preserve RGC, with a focus on connexin43 (Cx43) gap junction channel blockers.

  3. Repacking practice for G-3 engineering driller power unit with drive shaft of dual channel reverse circulation

    Institute of Scientific and Technical Information of China (English)

    Lihong ZHU; Kun YIN; Qingyan WANG; Yong HUANG

    2008-01-01

    In order to satisfy operating requirements for constant core drilling technology in reverse circulation with hollow-through DTH,the power unit of G-3 engineering driller was ameliorated. The new one with dual channel drive shaft, achieved the perfect assemble with transmission structure of the original power unit. It could interconvert according to need by using two sets of drive shafts with direct and reverse circulation. The repacked G-3 engineering driller carried on experiment in the field test in Luanchuan molybdenum mine of Henan, whose effect was very good.

  4. New Exact and Asymptotic Results of Dual-Branch MRC over Correlated Nakagami-m Fading Channels

    KAUST Repository

    Al-Quwaiee, Hessa

    2015-05-01

    We present in this paper a new performance analysis results of dual-branch maximal-ratio combining over correlated Nakagami-m fading channels with arbitrary fading parameter. In particular, we derive exact closed-form expressions of the outage probability, the average bit error rate, and the ergodic capacity in terms of the extended generalized bivariate Meijer G- function. Moreover, we also provide simple closed- form asymptotic expressions in the high signal-to- noise ratio regime of these three fundamental performance measures. © 2015 IEEE.

  5. Focus

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    According to a joint investigation by a group of top world companies, China has for the first time surpassed the U.S. to become the most favored destination for direct foreign investment. The Financial Times reports that the September 11th incident has provoked worries about security in the U.S among foreign investors. According to UN statistics, nearly US $50 billion of direct foreign investment was channeled into China in 2001, and still more is on its way. Foreign investment in the United States, on the other hand, dropped from its 2000 level of US $301 billion to US $125 biinon.

  6. Exact Outage Probability of Dual-Hop CSI-Assisted AF Relaying Over Nakagami-m Fading Channels

    KAUST Repository

    Xia, Minghua

    2012-10-01

    In this correspondence, considering dual-hop channel state information (CSI)-assisted amplify-and-forward (AF) relaying over Nakagami- m fading channels, the cumulative distribution function (CDF) of the end-to-end signal-to-noise ratio (SNR) is derived. In particular, when the fading shape factors m1 and m2 at consecutive hops take non-integer values, the bivariate H-function and G -function are exploited to obtain an exact analytical expression for the CDF. The obtained CDF is then applied to evaluate the outage performance of the system under study. The analytical results of outage probability coincide exactly with Monte-Carlo simulation results and outperform the previously reported upper bounds in the low and medium SNR regions.

  7. Hybrid laser-beam-shaping system for rotatable dual beams with long depth of focus

    Science.gov (United States)

    Chou, Fu-Lung; Chen, Cheng-Huan; Lin, Yu-Chung; Lin, Mao-Chi

    2016-08-01

    A laser processing system consisting of two diffractive elements and one refractive element is proposed enabling a Gaussian laser beam to be transformed into two beams with a depth of focus of up to 150 µm and focal spot smaller than 5 µm. For specific laser processing, the two beams are rotatable when the beam-splitting diffractive element is rotated. The overall system is versatile for laser cutting and drilling.

  8. On the Error Rate Analysis of Dual-Hop Amplify-and-Forward Relaying in Generalized-K Fading Channels

    Directory of Open Access Journals (Sweden)

    George P. Efthymoglou

    2010-01-01

    Full Text Available We present novel and easy-to-evaluate expressions for the error rate performance of cooperative dual-hop relaying with maximal ratio combining operating over independent generalized- fading channels. For this system, it is hard to obtain a closed-form expression for the moment generating function (MGF of the end-to-end signal-to-noise ratio (SNR at the destination, even for the case of a single dual-hop relay link. Therefore, we employ two different upper bound approximations for the output SNR, of which one is based on the minimum SNR of the two hops for each dual-hop relay link and the other is based on the geometric mean of the SNRs of the two hops. Lower bounds for the symbol and bit error rates for a variety of digital modulations can then be evaluated using the MGF-based approach. The final expressions are useful in the performance evaluation of amplify-and-forward relaying in a generalized composite radio environment.

  9. Dual state-parameter optimal estimation of one-dimensional open channel model using ensemble Kalman filter

    Institute of Scientific and Technical Information of China (English)

    LAI Rui-xun; FANG Hong-wei; HE Guo-jian; YU Xin; YANG Ming; WANG Ming

    2013-01-01

    In this paper,both state variables and parameters of one-dimensional open channel model are estimated using a framework of the Ensemble Kalman Filter (EnKF).Compared with observation,the predicted accuracy of water level and discharge are improved while the parameters of the model are identified simultaneously.With the principles of the EnKF,a state-space description of the Saint-Venant equation is constructed by perturbing the measurements with Gaussian error distribution.At the same time,the roughness,one of the key parameters in one-dimensional open channel,is also considered as a state variable to identify its value dynamically.The updated state variables and the parameters are then used as the initial values of the next time step to continue the assimilation process.The usefulness and the capability of the dual EnKF are demonstrated in the lower Yellow River during the water-sediment regulation in 2009.In the optimization process,the errors between the prediction and the observation are analyzed,and the rationale of inverse roughness is discussed.It is believed that (1) the flexible approach of the dual EnKF can improve the accuracy of predicting water level and discharge,(2) it provides a probabilistic way to identify the model error which is feasible to implement but hard to handle in other filter systems,and (3) it is practicable for river engineering and management.

  10. Airborne Doppler lidar at 532nm based on a tunable dual-channel Fabry-Perot interferometer

    Science.gov (United States)

    Feng, Jian-mei; Xing, Ting-wen; Lin, Wi-mei

    2009-07-01

    The aim of this paper is to explore a high-precision, a wide range of a frequency discrimination technique, and to study the application of this technique in the optical air data system (MOADS). To overcome the traditional equipment's shortcomings of short velocity detecting range such as pilot static tubes and wind wane, this technique can provide precision aviation data for various aerocrafts , without influencing pneumatic shape and performance of aerocraft. A tunable dual channel Fabry-Perot interferometer is used as a frequency discriminator in an airborne wind lidar system. This new frequency discriminator has been proposed to overcome the exiting frequency discriminator shortcoming. By adjusting the cavity length of interferometer, the speed of aerocraft can be detected and cut into several dynamic range. By this way, the Doppler wind lidar system can detect atmospheric parameters at the meantime, such as speed of aerocraft and temperature of atmosphere around the aerocraft, by analyzing the information of Rayleigh backscattering light. There are three main contribution in this paper: the first is discussing the basic theory of MOADS, calculational method and mathematic model of relative wind velocity between aircraft and wind are put forward.; the second is the parameter optimization of the dual-channel Fabry-Perot interferometer and the structure design of the interferometer; the third is the simulation of the performance and the accuracy of this system. Theory analysis and simulation results show this method is reasonable and practical.

  11. Compact Circular/Linear Polarization Dual-Band Prime-Focus Feed for Space Communication

    Directory of Open Access Journals (Sweden)

    Rastislav Galuscak

    2012-01-01

    Full Text Available We propose a novel, compact, prime-focus antenna feed for space communication. The feed requires full-wave simulator optimization for a given parabolic reflector and is designed to operate simultaneously on two bands, offering LHC/RHC polarizations for the 13 cm band and V/H polarizations for the 70 cm band. With performance results confirmed by measurement, it has been verified in practice that this compact feed is suitable for use in a low-noise Earth-Moon-Earth communication link.

  12. Pricing strategy in a dual-channel and remanufacturing supply chain system

    Science.gov (United States)

    Jiang, Chengzhi; Xu, Feng; Sheng, Zhaohan

    2010-07-01

    This article addresses the pricing strategy problems in a supply chain system where the manufacturer sells original products and remanufactured products via indirect retailer channels and direct Internet channels. Due to the complexity of that system, agent technologies that provide a new way for analysing complex systems are used for modelling. Meanwhile, in order to reduce the computational load of searching procedure for optimal prices and profits, a learning search algorithm is designed and implemented within the multi-agent supply chain model. The simulation results show that the proposed model can find out optimal prices of original products and remanufactured products in both channels, which lead to optimal profits of the manufacturer and the retailer. It is also found that the optimal profits are increased by introducing direct channel and remanufacturing. Furthermore, the effect of customer preference, direct channel cost and remanufactured unit cost on optimal prices and profits are examined.

  13. Treatment of the distal fracture in radioulna based on the volar wrist dual channel approach and postoperative X-ray diagnosis.

    Science.gov (United States)

    Li, Zheng; Zhang, Zhenwei; Yu, Shaoxiao; Bai, Yinwei; Lin, Huixin; Zeng, Jinhao; Ye, Xuelang; Xu, Dachuan

    2015-12-01

    The fracture of the distal ulna and radius is a kind of fracture that results in high morbidity and occurrence rate and contributes to about one-sixth of the entire body's fracture. In this study, we implemented the improved palmar wrist surgery by a volar wrist dual channel approach. Between 2011 and 2014, we have treated 67 distal radius fracture patients. We divided them into two parts randomly, and treat them by the Carpometacarpal direct approach solution and dual wrist palmar surgical approach solution respectively. After the surgery, the differences in the incidence of median nerve irritation are significant (P dual wrist palmar surgical approach solution are much less than that as compared to the Carpometacarpal direct approach solution (P dual wrist palmar surgical approach can lead to a successful treatment of the distal radius fractures volar distal radial ulnar by reducing the blind exposure problem. As such, the surgeon can complete treatment of fractures of the region under direct vision during operation. Furthermore, reducing the median nerve in the carpal tunnel and the structure of the stretch can decrease the incidence of postoperative complications. Postoperative X-ray diagnosis is then performed to examine the patients' recovery and assist in clinical follow-up. Our study proves that the volar wrist dual channel approach can be successfully achieved by a surface incision surgical implementation of the dual channel, and gives rise to a minimally invasive operation.

  14. Dual Focus on Form and Meaning in Task-based Oral English Teaching

    Institute of Scientific and Technical Information of China (English)

    林易

    2014-01-01

    The task-based approach has been gaining more and more popularity in recent years. Unlike the traditional language teaching approach, which puts much emphasis on the teaching and learning of language forms and skills, it regards the language process as one of learning through doing, emphasizes the central role of meaning in language use and insists that students should learn more effectively if they are fully engaged in a language task. However, due to the lack of an appropriate language environ-ment and limited time for English study, Chinese students may not make as much progress as expected in the unconscious inter-nalization of authentic language by focusing primarily on meaning. In fact the meaning of a language can not be separated from its form. The accurate expression of meaning depends on the proper use of language form. Therefore, in the application of the task-based approach, we should not neglect the study of language form. This paper analyses the causes for Chinese students ’low spo-ken English proficiency, describes the theoretical foundation and actual practice of the task-based approach, discusses its implica-tions for teaching oral English and makes some proposals for its appropriate application.

  15. How Human Resource Professionals Use Electronic Channels to Communicate CSR : A case study focused on Solvay's French industrial sites

    OpenAIRE

    Fournet, Clara; Pauly, Marissa

    2015-01-01

    Corporate Social Responsibility (CSR) has become a large concern for many companies with the rise of globalization. Oftentimes, companies are encouraged to communicate CSR externally, but not internally. This research focuses upon the internal communication of CSR, specifically how Human Resource (HR) professionals use electronic channels to communicate to employees. The scope of this research is focused solely upon HR professionals within Solvay’s French industrial sites, which produce chemi...

  16. Current understanding of KATP channels in neonatal diseases: focus on insulin secretion disorders

    Institute of Scientific and Technical Information of China (English)

    Yi QUAN; Andrew BARSZCZYK; Zhong-ping FENG; Hong-shuo SUN

    2011-01-01

    ATP-sensitive potassium (KATP) channels are cell metabolic sensors that couple cell metabolic status to electric activity, thus regulating many cellular functions. In pancreatic beta cells, KATP channels modulate insulin secretion in response to fluctuations in plasma glucose level, and play an important role in glucose homeostasis. Recent studies show that gain-of-function and loss-of-function mutations in KATP channel subunits cause neonatal diabetes mellitus and congenital hyperinsulinism respectively. These findings lead to significant changes in the diagnosis and treatment for neonatal insulin secretion disorders. This review describes the physiological and pathophysiological functions of KATP channels in glucose homeostasis, their specific roles in neonatal diabetes mellitus and congenital hyperinsulinism, as well as future perspectives of KATP channels in neonatal diseases.

  17. Exact Performance Analysis of Dual-Hop Semi-Blind AF Relaying over Arbitrary Nakagami-m Fading Channels

    KAUST Repository

    Xia, Minghua

    2011-10-01

    Relay transmission is promising for future wireless systems due to its significant cooperative diversity gain. The performance of dual-hop semi-blind amplify-and-forward (AF) relaying systems was extensively investigated, for transmissions over Rayleigh fading channels or Nakagami- fading channels with integer fading parameter. For the general Nakagami- fading with arbitrary values, the exact closed-form system performance analysis is more challenging. In this paper, we explicitly derive the moment generation function (MGF), probability density function (PDF) and moments of the end-to-end signal-to-noise ratio (SNR) over arbitrary Nakagami- fading channels with semi-blind AF relay. With these results, the system performance evaluation in terms of outage probability, average symbol error probability, ergodic capacity and diversity order, is conducted. The analysis developed in this paper applies to any semi-blind AF relaying systems with fixed relay gain, and two major strategies for computing the relay gain are compared in terms of system performance. All analytical results are corroborated by simulation results and they are shown to be efficient tools to evaluate system performance.

  18. Multi-channel Dual Clocks three-dimensional probability Random Multiple Access protocol for Wireless Public Bus Networks based on RTS/CTS mechanism

    Directory of Open Access Journals (Sweden)

    Zhou Sheng Jie

    2016-01-01

    Full Text Available A MAC protocol for public bus networks, called Bus MAC protocol, designed to provide high quality Internet service for bus passengers. The paper proposed a multi-channel dual clocks three-demission probability random multiple access protocol based on RTS/CTS mechanism, decreasing collisions caused by multiple access from multiple passengers. Use the RTS/CTS mechanism increases the reliability and stability of the system, reducing the collision possibility of the information packets to a certain extent, improves the channel utilization; use the multi-channel mechanism, not only enables the channel load balancing, but also solves the problem of the hidden terminal and exposed terminal. Use the dual clocks mechanism, reducing the system idle time. At last, the different selection of the three-dimensional probabilities can make the system throughput adapt to the network load which could realize the maximum of the system throughput.

  19. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials

    DEFF Research Database (Denmark)

    Calloe, Kirstine; Di Diego, José M; Hansen, Rie Schultz

    2016-01-01

    in cultured canine cardiac myocytes and determined whether a dual K(+) current activator can normalize K(+) currents and restore action potential (AP) configuration. METHODS AND RESULTS: Ventricular myocytes were isolated and cultured for up to 48h. Current and voltage clamp recordings were made using patch...... of EADs. Our results suggest a potential benefit of K(+) current activators under conditions of reduced repolarization reserve including heart failure....

  20. Suppression of surface-originated gate lag by a dual-channel AlN/GaN high electron mobility transistor architecture

    Science.gov (United States)

    Deen, David A.; Storm, David F.; Scott Katzer, D.; Bass, R.; Meyer, David J.

    2016-08-01

    A dual-channel AlN/GaN high electron mobility transistor (HEMT) architecture is demonstrated that leverages ultra-thin epitaxial layers to suppress surface-related gate lag. Two high-density two-dimensional electron gas (2DEG) channels are utilized in an AlN/GaN/AlN/GaN heterostructure wherein the top 2DEG serves as a quasi-equipotential that screens potential fluctuations resulting from distributed surface and interface states. The bottom channel serves as the transistor's modulated channel. Dual-channel AlN/GaN heterostructures were grown by molecular beam epitaxy on free-standing hydride vapor phase epitaxy GaN substrates. HEMTs fabricated with 300 nm long recessed gates demonstrated a gate lag ratio (GLR) of 0.88 with no degradation in drain current after bias stressed in subthreshold. These structures additionally achieved small signal metrics ft/fmax of 27/46 GHz. These performance results are contrasted with the non-recessed gate dual-channel HEMT with a GLR of 0.74 and 82 mA/mm current collapse with ft/fmax of 48/60 GHz.

  1. An easy prepared dual-channel chemosensor for selective and instant detection of fluoride based on double Schiff-base

    Science.gov (United States)

    Leng, Yan-Li; Zhang, Jian-Hui; Li, Qiao; Zhang, You-Ming; Lin, Qi; Yao, Hong; Wei, Tai-Bao

    2016-10-01

    A colorimetric and fluorescent dual-channel fluoride chemosensor N,N‧-bis (4-diethylaminosalicylidene) hydrazine (sensor S) bearing two imine groups has been designed and synthesized. This structurally simple probe displays rapid response and high selectivity for fluoride over other common anions (Cl-, Br-, I-, AcO-, H2PO4-, HSO4-, ClO4-, CN- and SCN-) in a highly polar aqueous DMSO solution. Mechanism studies suggested that the sensor firstly combined with F- through hydrogen bonds and then experienced the deprotonation process at higher concentrations of F- anion to the two Ar-OH groups. The detection limit was 5.78 × 10- 7 M of F-, which points to the high detection sensitivity. Test strips based on sensor S were fabricated, which could act as a convenient and efficient F- test kit to detect F- for "in-the-field" measurement.

  2. Performance Analysis of Multibranch Dual-Hop Nonregenerative Relay Systems with EGC in Nakagami-m Channels

    Directory of Open Access Journals (Sweden)

    H. Suzuki

    2010-01-01

    Full Text Available The end-to-end performance of multibranch dual-hop wireless communication systems with nonregenerative relays and equal gain combiner (EGC at the destination over independent Nakagami-m fading channels is studied. We present new closed form expressions for probability distribution function (PDF and cumulative distribution function (CDF of end-to-end signal to noise ratio (SNR per branch in terms of Meijer's G function. From these results, analytical formulae for the moments of the output SNR, the average overall SNR, the amount of fading, and the spectral efficiency are also obtained in closed form. Instead of using moments-based approach to analyze the asymptotic error performance of the system, we employ the characteristic function (CHF method to calculate the average bit error probability (ABEP and the outage probability for several coherent and noncoherent modulation schemes. The accuracy of the analytical formulae is verified by various numerical results and simulations.

  3. Scheduling for dual-hop block-fading channels with two source-user pairs sharing one relay

    KAUST Repository

    Zafar, Ammar

    2013-09-01

    In this paper, we maximize the achievable rate region of a dual-hop network with two sources serving two users independently through a single shared relay. We formulate the problem as maximizing the sum of the weighted long term average throughputs of the two users under stability constraints on the long term throughputs of the source-user pairs. In order to solve the problem, we propose a joint user-and-hop scheduling scheme, which schedules the first or second hop opportunistically based on instantaneous channel state information, in order to exploit multiuser diversity and multihop diversity gains. Numerical results show that the proposed joint scheduling scheme enhances the achievable rate region as compared to a scheme that employs multi-user scheduling on the second-hop alone. Copyright © 2013 by the Institute of Electrical and Electronic Engineers, Inc.

  4. A fusion algorithm for infrared and visible images based on adaptive dual-channel unit-linking PCNN in NSCT domain

    Science.gov (United States)

    Xiang, Tianzhu; Yan, Li; Gao, Rongrong

    2015-03-01

    In this paper, a novel fusion algorithm based on the adaptive dual-channel unit-linking pulse coupled neural network (PCNN) for infrared and visible images fusion in nonsubsampled contourlet transform (NSCT) domain is proposed. The flexible multi-resolution and directional expansion for images of NSCT are associated with global coupling and pulse synchronization characteristic of dual-PCNN. Compared with other dual-PCNN models, the proposed model possesses fewer parameters and is not difficult to implement adaptive, which is more suitable for image fusion. Firstly, the source images were multi-scale and multi-directional decomposed by NSCT. Then, to make dual-channel PCNN adaptive, the average gradient of each pixel was presented as the linking strength, and the time matrix was presented to determine the iteration number adaptively. In this fusion scheme, a novel sum modified-Laplacian of low-frequency subband and a modified spatial frequency of high-frequency subband were input to motivate the adaptive dual-channel unit-linking PCNN, respectively. Experimental results demonstrate that the proposed algorithm can significantly improve image fusion performance, accomplish notable target information and high contrast, simultaneously preserve rich details information, and excel other typical current methods in both objective evaluation criteria and visual effect.

  5. Simultaneous measurement of temperature and emissivity of lunar regolith simulant using dual-channel millimeter-wave radiometry.

    Science.gov (United States)

    McCloy, J S; Sundaram, S K; Matyas, J; Woskov, P P

    2011-05-01

    Millimeter wave (MMW) radiometry can be used for simultaneous measurement of emissivity and temperature of materials under extreme environments (high temperature, pressure, and corrosive environments). The state-of-the-art dual channel MMW passive radiometer with active interferometric capabilities at 137 GHz described here allows for radiometric measurements of sample temperature and emissivity up to at least 1600 °C with simultaneous measurement of sample surface dynamics. These capabilities have been used to demonstrate dynamic measurement of melting of powders of simulated lunar regolith and static measurement of emissivity of solid samples. The paper presents the theoretical background and basis for the dual-receiver system, describes the hardware in detail, and demonstrates the data analysis. Post-experiment analysis of emissivity versus temperature allows further extraction from the radiometric data of millimeter wave viewing beam coupling factors, which provide corroboratory evidence to the interferometric data of the process dynamics observed. These results show the promise of the MMW system for extracting quantitative and qualitative process parameters for industrial processes and access to real-time dynamics of materials behavior in extreme environments.

  6. Different Evolutionary Origins for the Reach and the Grasp: An Explanation for Dual Visuomotor Channels in Primate Parietofrontal Cortex

    Directory of Open Access Journals (Sweden)

    Jenni M Karl

    2013-12-01

    Full Text Available The Dual Visuomotor Channel Theory proposes that manual prehension consists of two temporally integrated movements, each subserved by distinct visuomotor pathways in occipitoparietofrontal cortex. The Reach is mediated by a dorsomedial pathway and transports the hand in relation to the target’s extrinsic properties (i.e., location and orientation. The Grasp is mediated by a dorsolateral pathway and opens, preshapes, and closes the hand in relation to the target’s intrinsic properties (i.e., size and shape. Here, neuropsychological, developmental, and comparative evidence is reviewed to show that the Reach and the Grasp have different evolutionary origins. First, the removal or degradation of vision causes prehension to decompose into its constituent Reach and Grasp components, which are then executed in sequence or isolation. Similar decomposition occurs in optic ataxic patients following cortical injury to the Reach and Grasp pathways and after corticospinal tract lesions in non-human primates. Second, early nonvisual PreReach and PreGrasp movements develop into mature Reach and Grasp movements but are only integrated under visual control after a prolonged developmental period. Third, comparative studies reveal many similarities between stepping movements and the Reach and between food handling movements and the Grasp, suggesting that the Reach and Grasp are derived from different evolutionary antecedents. The evidence is discussed in relation to the ideas that dual visuomotor channels in primate parietofrontal cortex emerged as a result of distinct evolutionary origins for the Reach and Grasp; that foveated vision in primates serves to integrate the Reach and Grasp into a single prehensile act; and, that flexible recombination of discrete Reach and Grasp movements under various forms of sensory and cognitive control can produce adaptive behavior.

  7. A novel microfluidic mixer based on dual-hydrodynamic focusing for interrogating the kinetics of DNA-protein interaction.

    Science.gov (United States)

    Li, Ying; Xu, Fei; Liu, Chao; Xu, Youzhi; Feng, Xiaojun; Liu, Bi-Feng

    2013-08-21

    Kinetic measurement of biomacromolecular interaction plays a significant role in revealing the underlying mechanisms of cellular activities. Due to the small diffusion coefficient of biomacromolecules, it is difficult to resolve the rapid kinetic process with traditional analytical methods such as stopped-flow or laminar mixers. Here, we demonstrated a unique continuous-flow laminar mixer based on microfluidic dual-hydrodynamic focusing to characterize the kinetics of DNA-protein interactions. The time window of this mixer for kinetics observation could cover from sub-milliseconds to seconds, which made it possible to capture the folding process with a wide dynamic range. Moreover, the sample consumption was remarkably reduced to <0.55 μL min⁻¹, over 1000-fold saving in comparison to those reported previously. We further interrogated the interaction kinetics of G-quadruplex and the single-stranded DNA binding protein, indicating that this novel micromixer would be a useful approach for analyzing the interaction kinetics of biomacromolecules.

  8. Single channel layer, single sheath-flow inlet microfluidic flow cytometer with three-dimensional hydrodynamic focusing.

    Science.gov (United States)

    Lin, Shiang-Chi; Yen, Pei-Wen; Peng, Chien-Chung; Tung, Yi-Chung

    2012-09-07

    Flow cytometry is a technique capable of optically characterizing biological particles in a high-throughput manner. In flow cytometry, three dimensional (3D) hydrodynamic focusing is critical for accurate and consistent measurements. Due to the advantages of microfluidic techniques, a number of microfluidic flow cytometers with 3D hydrodynamic focusing have been developed in recent decades. However, the existing devices consist of multiple layers of microfluidic channels and tedious fluidic interconnections. As a result, these devices often require complicated fabrication and professional operation. Consequently, the development of a robust and reliable microfluidic flow cytometer for practical biological applications is desired. This paper develops a microfluidic device with a single channel layer and single sheath-flow inlet capable of achieving 3D hydrodynamic focusing for flow cytometry. The sheath-flow stream is introduced perpendicular to the microfluidic channel to encircle the sample flow. In this paper, the flow fields are simulated using a computational fluidic dynamic (CFD) software, and the results show that the 3D hydrodynamic focusing can be successfully formed in the designed microfluidic device under proper flow conditions. The developed device is further characterized experimentally. First, confocal microscopy is exploited to investigate the flow fields. The resultant Z-stack confocal images show the cross-sectional view of 3D hydrodynamic with flow conditions that agree with the simulated ones. Furthermore, the flow cytometric detections of fluorescence beads are performed using the developed device with various flow rate combinations. The measurement results demonstrate that the device can achieve great detection performances, which are comparable to the conventional flow cytometer. In addition, the enumeration of fluorescence-labelled cells is also performed to show its practicality for biological applications. Consequently, the microfluidic

  9. Polarization-mediated Debye-screening of surface potential fluctuations in dual-channel AlN/GaN high electron mobility transistors

    Science.gov (United States)

    Deen, David A.; Miller, Ross A.; Osinsky, Andrei V.; Downey, Brian P.; Storm, David F.; Meyer, David J.; Scott Katzer, D.; Nepal, Neeraj

    2016-12-01

    A dual-channel AlN/GaN/AlN/GaN high electron mobility transistor (HEMT) architecture is proposed, simulated, and demonstrated that suppresses gate lag due to surface-originated trapped charge. Dual two-dimensional electron gas (2DEG) channels are utilized such that the top 2DEG serves as an equipotential that screens potential fluctuations resulting from surface trapped charge. The bottom channel serves as the transistor's modulated channel. Two device modeling approaches have been performed as a means to guide the device design and to elucidate the relationship between the design and performance metrics. The modeling efforts include a self-consistent Poisson-Schrodinger solution for electrostatic simulation as well as hydrodynamic three-dimensional device modeling for three-dimensional electrostatics, steady-state, and transient simulations. Experimental results validated the HEMT design whereby homo-epitaxial growth on free-standing GaN substrates and fabrication of the same-wafer dual-channel and recessed-gate AlN/GaN HEMTs have been demonstrated. Notable pulsed-gate performance has been achieved by the fabricated HEMTs through a gate lag ratio of 0.86 with minimal drain current collapse while maintaining high levels of dc and rf performance.

  10. effect of the plasma ion channel on self-focusing of a Gaussian laser pulse in underdense plasma

    Directory of Open Access Journals (Sweden)

    Sh Irani

    2013-09-01

    Full Text Available  We have considered the self-focusing of a Gaussian laser pulse in unmagnetized plasma. High-intensity electromagnetic fields cause the variation of electron density in plasma. These changes in the special conditions cause the acceleration of electrons to the higher energy and velocities. Thus the equation of plasma density evolution was obtained considering the electrons ponderomotive force. Then, an equation for the width of laser pulse with a relativistic mass correction term and the effect of ion channel were derived and the propagation of high-intensity laser pulse in an underdense plasma with weak relativistic approximation was investigated. It is shown that the ratio of ion channel radius to spot size could result in different forms of self focusing for the laser pulse in plasma.

  11. Dual-Channel Particle Filter Based Track-Before-Detect for Monopulse Radar

    Directory of Open Access Journals (Sweden)

    Fei Cai

    2014-01-01

    Full Text Available A particle filter based track-before-detect (PF-TBD algorithm is proposed for the monopulse high pulse repetition frequency (PRF pulse Doppler radar. The actual measurement model is adopted, in which the range is highly ambiguous and the sum and difference channels exist in parallel. A quantization method is used to approximate the point spread function to reduce the computation load. The detection decisions of the PF-TBD are fed to a binary integrator to further improve the detection performance. Simulation results show that the proposed algorithm can detect and track the low SNR target efficiently. The detection performance is improved significantly for both the single frame and the multiframe detection compared with the classical detector. A performance comparison with the PF-TBD using sum channel only is also supplied.

  12. Dual-channel spontaneous emission of quantum dots in magnetic metamaterials.

    Science.gov (United States)

    Decker, Manuel; Staude, Isabelle; Shishkin, Ivan I; Samusev, Kirill B; Parkinson, Patrick; Sreenivasan, Varun K A; Minovich, Alexander; Miroshnichenko, Andrey E; Zvyagin, Andrei; Jagadish, Chennupati; Neshev, Dragomir N; Kivshar, Yuri S

    2013-01-01

    Metamaterials, artificial electromagnetic media realized by subwavelength nano-structuring, have become a paradigm for engineering electromagnetic space, allowing for independent control of both electric and magnetic responses of the material. Whereas most metamaterials studied so far are limited to passive structures, the need for active metamaterials is rapidly growing. However, the fundamental question on how the energy of emitters is distributed between both (electric and magnetic) interaction channels of the metamaterial still remains open. Here we study simultaneous spontaneous emission of quantum dots into both of these channels and define the control parameters for tailoring the quantum-dot coupling to metamaterials. By superimposing two orthogonal modes of equal strength at the wavelength of quantum-dot photoluminescence, we demonstrate a sharp difference in their interaction with the magnetic and electric metamaterial modes. Our observations reveal the importance of mode engineering for spontaneous emission control in metamaterials, paving a way towards loss-compensated metamaterials and metamaterial nanolasers.

  13. Tapered plasma channels to phase-lock accelerating and focusing forces in laser-plasma accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Rittershofer, W.; Schroeder, C.B.; Esarey, E.; Gruner, F.J.; Leemans, W.P.

    2010-05-17

    Tapered plasma channels are considered for controlling dephasing of a beam with respect to a plasma wave driven by a weakly-relativistic, short-pulse laser. Tapering allows for enhanced energy gain in a single laser plasma accelerator stage. Expressions are derived for the taper, or longitudinal plasma density variation, required to maintain a beam at a constant phase in the longitudinal and/or transverse fields of the plasma wave. In a plasma channel, the phase velocities of the longitudinal and transverse fields differ, and, hence, the required tapering differs. The length over which the tapered plasma density becomes singular is calculated. Linear plasma tapering as well as discontinuous plasma tapering, which moves beams to adjacent plasma wave buckets, are also considered. The energy gain of an accelerated electron in a tapered laser-plasma accelerator is calculated and the laser pulse length to optimize the energy gain is determined.

  14. Performance Analysis of Dual-hop MIMO Relay Systems with MRT&RAS in the Presence of Co-channel Interference

    Science.gov (United States)

    Xu, Xiaoming; Cai, Yueming; Yang, Weiwei

    2013-09-01

    This paper focuses on the downlink dual-hop multiple-input multiple-output (MIMO) amplify-and-forward (AF) relay systems that employ the maximal-ratio transmission and receive antenna selection scheme (MRT&RAS) for use in each hop. The system under consideration is equipped with arbitrary NS, NR, and ND antennas at the base station (BS), relay station (RS), and mobile station (MS), respectively. The system performance has been investigated over Nakagami-m fading in presence of independent but not necessarily identically distributed co-channel interferences (CCIs) at both the RS and MS. First, we derive an accurate closed-form approximate expression for the outage probability and a single-integral expression for the average symbol error rate (SER), respectively. Besides, to render direct insights into the combined effect of multiple-antenna and interference on the system performance, the asymptotic expressions for the outage probability and the average SER are also presented. Furthermore, we determine the optimal power allocation (OPA) by using the exact and asymptotic methods, respectively, such that the outage probability is minimized. Finally, numerical results validate the correctness of the derived expressions and show that OPA offers superior performance over uniform power allocation. Our analysis and results provide insights on investigating and optimizing the performance of the downlink MIMO relay transmission in practical interference-limited wireless networks.

  15. Continuous focusing of microparticles using inertial lift force and vorticity via multi-orifice microfluidic channels.

    Science.gov (United States)

    Park, Jae-Sung; Song, Suk-Heung; Jung, Hyo-Il

    2009-04-07

    We developed a new microfluidic method for focusing microparticles through the combined use of inertial lift forces and turbulent secondary flows generated in a topographically patterned microchannel. The mechanism of particle focusing is based on the hydrodynamic inertial forces exerted on particles migrating along a non-circular microchannel, i.e.tubular pinch effect and wall effect, which induce particle movement away from walls and along a specific lateral position in the microchannel. With the extraordinary geometry of multi-orifice microchannel, an ordered and focused particle distribution was achieved at central or side regions according to a particle Reynolds number (Re(p)) range. The focusing of particles was controlled by the particle Reynolds number, microchannel length, and volume fraction of particles in suspension. This method will be beneficial in particle focusing processes in a microfluidic device since it offers continuous, high-throughput performance and simple operation.

  16. Dual-channel capillary electrophoresis for simultaneous determination of cations and anions.

    Science.gov (United States)

    Opekar, František; Tůma, Petr

    2016-05-13

    An original electrophoresis apparatus for simultaneous rapid determination of cations and anions has been designed and tested. The separation part of the apparatus consists of two identical fused-silica capillaries, each with a length of 10.5cm and inner diameter of 25μm. The injection space is formed by the crossing of four channels in a plexiglass cross-piece. The capillaries pass through two opposing channels and their injection ends are located opposite one another at a distance of approx. 0.5mm in the centre of the crossing point. The exit ends of the capillaries are placed in vessels containing the background electrolyte in which are immersed the electrodes of a high-voltage source. Contactless conductivity detectors with semi-cylindrical electrodes are located 2cm from the exit ends of the capillaries. The injection part of the apparatus consists of two piezoelectric micro-pumps bringing the solution through another channel in the cross-piece to the injection ends of the capillary. During the injection, the sample is brought through one of them and is injected electrokinetically for a defined time. Then the sample zone is forced out of the injection space by a stream of background electrolyte from the second micro-pump. The timing of the injection process is computer-controlled. Thus the equipment can be considered to constitute electrophoresis in one capillary with injection into its centre. The use of short capillaries and miniature micro-pumps without other mechanical components enabled the construction of the apparatus on a board with dimensions of 20×25cm. The proposed equipment was used to test simultaneous separation of a mixture of cations and anions, NH4(+), K(+), Ca(2+), Mg(2+), Sr(2+), Ba(2+), Cl(-), NO3(-), SO4(2-), ClO3(-) and F(-), in BGE with composition 500mM HAc+20mM Tris+2mM 18-crown-6 (pH 3.3). Baseline separation of all the components was achieved in time less than 1min. Quantification of the content of nitrate nitrogen (determined as

  17. Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images

    LENUS (Irish Health Repository)

    Singan, Vasanth R

    2011-10-21

    Abstract Background Accurate quantitative co-localization is a key parameter in the context of understanding the spatial co-ordination of molecules and therefore their function in cells. Existing co-localization algorithms consider either the presence of co-occurring pixels or correlations of intensity in regions of interest. Depending on the image source, and the algorithm selected, the co-localization coefficients determined can be highly variable, and often inaccurate. Furthermore, this choice of whether co-occurrence or correlation is the best approach for quantifying co-localization remains controversial. Results We have developed a novel algorithm to quantify co-localization that improves on and addresses the major shortcomings of existing co-localization measures. This algorithm uses a non-parametric ranking of pixel intensities in each channel, and the difference in ranks of co-localizing pixel positions in the two channels is used to weight the coefficient. This weighting is applied to co-occurring pixels thereby efficiently combining both co-occurrence and correlation. Tests with synthetic data sets show that the algorithm is sensitive to both co-occurrence and correlation at varying levels of intensity. Analysis of biological data sets demonstrate that this new algorithm offers high sensitivity, and that it is capable of detecting subtle changes in co-localization, exemplified by studies on a well characterized cargo protein that moves through the secretory pathway of cells. Conclusions This algorithm provides a novel way to efficiently combine co-occurrence and correlation components in biological images, thereby generating an accurate measure of co-localization. This approach of rank weighting of intensities also eliminates the need for manual thresholding of the image, which is often a cause of error in co-localization quantification. We envisage that this tool will facilitate the quantitative analysis of a wide range of biological data sets

  18. Post-filamentation propagation of high-power laser pulses in air in the regime of narrowly focused light channels

    Science.gov (United States)

    Geints, Yu. E.; Zemlyanov, A. A.; Ionin, A. A.; Mokrousova, D. V.; Seleznev, L. V.; Sinitsyn, D. V.; Sunchugasheva, E. S.

    2016-11-01

    We report the results of experimental and theoretical studies of the post-filamentation stage of nonlinear propagation of high-power pulsed radiation from a Ti : sapphire laser in air. We have for the first time obtained the experimental dependences of the angular divergence of specific spatially localised high-intensity light structures that are observed in the beam after its multiple filamentation (post-filamentation of channels) when varying the initial focusing of laser radiation and its energy. It is found that the angular divergence of the post-filamentation channels decreases with increasing pulse energy and reducing beam numerical aperture. The experimental dependences are qualitatively interpreted based on the diffraction model of the Bessel - Gaussian beam.

  19. Janus droplet parallel arrangements using a simple Y-channel flow-focusing microfluidic device

    Science.gov (United States)

    Cheng, Long; Cai, Bo; Zuo, Yunfeng; Xiao, Liang; Rao, Lang; He, Zhaobo; Yang, Yi; Liu, Wei; Guo, Shishang; Zhao, Xing-Zhong

    2017-04-01

    Due to its unique advantages such as monodispersity and high throughput, droplet microfluidics has been widely used to generate diverse droplets/particles that have specific structures. Herein, we implemented Janus droplet parallel arrangements in a flow-focusing microchip through regulating corresponding fluid flow rates. Initially, fluorescence dye and PBS buffer solution kept laminar flow before the flow-focusing orifice and then was sheared into Janus droplets. Droplet diameter and corresponding generation frequency could be effectively manipulated. Subsequently, the generation of different Janus droplet parallel arrangements (e.g. monolayer, double-layer or three-layer arrangement) could be achieved by fluid regulation.

  20. Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function

    Science.gov (United States)

    Kassis, Timothy; Kohan, Alison B.; Weiler, Michael J.; Nipper, Matthew E.; Cornelius, Rachel; Tso, Patrick; Brandon Dixon, J.

    2012-08-01

    Nearly all dietary lipids are transported from the intestine to venous circulation through the lymphatic system, yet the mechanisms that regulate this process remain unclear. Elucidating the mechanisms involved in the functional response of lymphatics to changes in lipid load would provide valuable insight into recent implications of lymphatic dysfunction in lipid related diseases. Therefore, we sought to develop an in situ imaging system to quantify and correlate lymphatic function as it relates to lipid transport. The imaging platform provides the capability of dual-channel imaging of both high-speed bright-field video and fluorescence simultaneously. Utilizing post-acquisition image processing algorithms, we can quantify correlations between vessel pump function, lymph flow, and lipid concentration of mesenteric lymphatic vessels in situ. All image analysis is automated with customized LabVIEW virtual instruments; local flow is measured through lymphocyte velocity tracking, vessel contraction through measurements of the vessel wall displacement, and lipid uptake through fluorescence intensity tracking of an orally administered fluorescently labelled fatty acid analogue, BODIPY FL C16. This system will prove to be an invaluable tool for scientists studying intestinal lymphatic function in health and disease, and those investigating strategies for targeting the lymphatics with orally delivered drugs to avoid first pass metabolism.

  1. Manufacturing and characterization of porous SiC for flow channel inserts in dual-coolant blanket designs

    Energy Technology Data Exchange (ETDEWEB)

    Bereciartu, Ainhoa [CEIT and Tecnun (University of Navarra), Manuel de Lardizabal 15, 20018 San Sebastian (Spain); Ordas, Nerea, E-mail: nordas@ceit.es [CEIT and Tecnun (University of Navarra), Manuel de Lardizabal 15, 20018 San Sebastian (Spain); Garcia-Rosales, Carmen [CEIT and Tecnun (University of Navarra), Manuel de Lardizabal 15, 20018 San Sebastian (Spain); Morono, Alejandro; Malo, Marta; Hodgson, Eric R. [CIEMAT, Avenida Complutense 22, 28040 Madrid (Spain); Abella, Jordi [Institut Quimic de Sarria, University Ramon Llull, Via Augusta 390, 08017 Barcelona (Spain); Sedano, Luis [CIEMAT, Avenida Complutense 22, 28040 Madrid (Spain)

    2011-10-15

    SiC is the primary candidate for the flow channel inserts in dual-coolant blanket concepts. Porous SiC ceramics are attractive candidates for this non-structural application, since they can satisfy the required properties through a low cost manufacturing route, compared to SiC{sub f}/SiC. This work shows first results of the manufacturing of porous SiC ceramics prepared with different amounts of Y{sub 2}O{sub 3} and Al{sub 2}O{sub 3} as sintering additives. C powders were used as pore-formers by their burnout during oxidation after sintering. Comparison of microstructure, porosity, flexural strength, thermal and electrical conductivity and corrosion under Pb-15.7Li of porous SiC without and with sintering additives is presented. The addition of 2.5 wt.% of Y{sub 2}O{sub 3} and Al{sub 2}O{sub 3} improves the mechanical properties, and reduces the thermal and electrical conductivity down to reasonable values. Preliminary corrosion tests under Pb-15.7 Li at 500 deg. C show that the absence of a dense coating on porous SiC leads to poor corrosion behavior.

  2. A high-efficiency, low-noise power solution for a dual-channel GNSS RF receiver

    Science.gov (United States)

    Jian, Shi; Taishan, Mo; Jianlian, Le; Yebing, Gan; Chengyan, Ma; Tianchun, Ye

    2012-08-01

    A high-efficiency low-noise power solution for a dual-channel GNSS RF receiver is presented. The power solution involves a DC—DC buck converter and a followed low-dropout regulator (LDO). The pulse-width-modulation (PWM) control method is adopted for better noise performance. An improved low-power high-frequency PWM control circuit is proposed, which halves the average quiescent current of the buck converter to 80 μA by periodically shutting down the OTA. The size of the output stage has also been optimized to achieve high efficiency under a light load condition. In addition, a novel soft-start circuit based on a current limiter has been implemented to avoid inrush current. Fabricated with commercial 180-nm CMOS technology, the DC—DC converter achieves a peak efficiency of 93.1% under a 2 MHz working frequency. The whole receiver consumes only 20.2 mA from a 3.3 V power supply and has a noise figure of 2.5 dB.

  3. Transceiver Design at Relay and Destination for Dual-Hop Non-regenerative MIMO-OFDM Relay Systems Under Channel Uncertainties

    CERN Document Server

    Xing, Chengwen; Wu, Yik-Chung; Ng, Tung-Sang

    2010-01-01

    In this paper, joint design of linear relay precoder and destination equalizer for dual-hop non-regenerative amplify-and-forward (AF) MIMO-OFDM systems under channel estimation errors is investigated. Second order moments of channel estimation errors in the two hops are first deduced. Then based on the Bayesian framework, joint design of linear robust precoder at the relay and equalizer at the destination is proposed to minimize the total mean-square-error (MSE) of the output signal at the destination. The optimal designs for both correlated and uncorrelated channel estimation errors are considered. The relationship with existing algorithms is also disclosed. Simulation results show that the proposed robust designs outperform the design based on estimated channel state information only.

  4. Dual channel fluorescence engineering on the nano-patterened metamaterial (Conference Presentation)

    Science.gov (United States)

    Wu, Huijun; Tseng, Ming Lun; Tsai, Wei Yi; Chen, Ting-Yu; Chien, Yihsin; Chang, Yun-Chorng; Tsai, Din Ping

    2016-09-01

    Upconversion fluorescence from Lanthanide-doped nanocrystals has attracted widespread interests because of its greatly potential applications in various fields, such as photonic crystal lasers, material science, biological therapy, and so on. However, the relatively low quantum yield (typically chemical methods, plasmonic structures have been adopted as another strategy to improve the radiation efficiency and control the relaxation process of the upcovnersion nanocrystals. We designed the anti-symmetric split ring resonators with various periods and the fishnet structures. The surface plasmon resonance peaks of the structure shift as the periods varies. For example, in a multi-layered plamsonic metasurface with the period of 250nm, both the electric and magnetic modes could be generated simultaneously when excited by the incident light with proper polarization. This plasmonic structure provides two different channels for the enhancement of upconversion fluorescence. The resonance peak of 650nm is magnetic resonance mode, while the peak of 980nm is electric resonance mode. The resonance peak of 980nm coincides with the absorption band of the Lanthanide-dopoed nanocrystal, and the peak of 650nm matches with its emission band. We found that the upconversion fluorescence intensity could be enhanced more than 10 times when the electric resonance frequency of the metasurface matches with the absorption band of the upconversion nanocrystals, while the magnetic mode overlaps with its emission band. This is due to the local density of optical states was significantly enhanced by the plasmonic metasurface. The detailed results and mechanism will be discussed.

  5. Overview of Research on Dual-Channel Supply Chain Management%双渠道供应链管理研究综述

    Institute of Scientific and Technical Information of China (English)

    曹细玉; 覃艳华; 陈本松

    2014-01-01

    To grasp the developing status and the future research emphasis of dual-channel supply chain management, which can play a guiding role to effectively implement the dual channel supply chain,the paper combs the domestic and in-ternational research on the choice,pricing strategies,conflict,coordination mechanism of dual channel supply chain ,and puts forward the main research directions in the future.%为全面把握双渠道供应链管理的研究现状及未来研究的重点,以便对有效实施双渠道供应链管理有着指导借鉴作用,在对国内外学术界关于双渠道供应链的选择、冲突、定价策略、协调机制等方面的研究进行梳理与评析的基础上,提出未来研究的主要方向。

  6. Control of beam halo-chaos by Gauss function in the triangle periodic-focusing channel

    Institute of Scientific and Technical Information of China (English)

    Yu Hai-Jun; Bai Long; Weng Jia-Qiang; Luo Xiao-Shu; Fang Jin-Qing

    2008-01-01

    This paper studies the Kapchinsky-Vladimirsky (K-V) beam through a triangle periodic-focusing magnetic field by using the particle-core model. The beam halo-chaos is found, and an idea of Gauss function controller is proposed based on the strategy of controlling the halo-chaos. It performs multiparticle simulation to control the halo by using the Gauss function control method. The numerical results show that the halo-chaos and its regeneration can be eliminated effectively, and that the radial particle density is uniform at the centre of the beam as long as the control method and appropriate parameter are chosen.

  7. 零售商双渠道供应链定价及协调研究%On pricing and coordination strategy of retailers’ dual channel supply chain

    Institute of Scientific and Technical Information of China (English)

    仲凯旋; 巩永华; 薛殿中

    2015-01-01

    This paper studies pricing and coordination issues in retailers’ dual channel supply chain, and es-tablishes a two-party game model between manufacturers and retailers. Pricing strategies under centralized and de-centralized decision-making are analyzed. On this basis, Revenue Share Contract is designed to alleviate channel conflict. The results indicate that it is necessary for retailers to offer proper revenue allocation proportion in order to achieve Pareto improvement in profits and coordinate entire dual channel supply chain. Under the environment of dual channel competition, there is a certain difference in the prices of online&offline. Enterprises should develop different sales prices for different channels in the specific situation.%研究了零售商双渠道供应链的定价策略和协调问题,建立制造商和零售商两方博弈模型,分析了集中决策和分散决策两种情境下的定价决策均衡解,并设计收入共享契约来解决零售商双渠道存在的双重边际化效应。结果表明,零售商需要提供合理的收入分配比例才能实现供应链各成员利润的Pareto改进,并最终协调整个双渠道供应链。在双渠道竞争环境下,线上线下不能采取完全同价策略,企业应针对不同渠道的具体情况制定不同的销售价格。

  8. Concentration gradient focusing and separation in a silica nanofluidic channel with a non-uniform electroosmotic flow.

    Science.gov (United States)

    Hsu, Wei-Lun; Harvie, Dalton J E; Davidson, Malcolm R; Jeong, Helen; Goldys, Ewa M; Inglis, David W

    2014-09-21

    The simultaneous concentration gradient focusing and separation of proteins in a silica nanofluidic channel of various geometries is investigated experimentally and theoretically. Previous modelling of a similar device [Inglis et al., Angew. Chem. Int. Ed., 2011, 50, 7546] assumed a uniform velocity profile along the length of the nanochannel. Using detailed numerical analysis incorporating charge regulation and viscoelectric effects, we show that in reality the varying axial electric field and varying electric double layer thickness caused by the concentration gradient, induce a highly non-uniform velocity profile, fundamentally altering the protein trapping mechanism: the direction of the local electroosmotic flow reverses and two local vortices are formed near the centreline of the nanochannel at the low salt concentration end, enhancing trapping efficiency. Simulation results for yellow/red fluorescent protein R-PE concentration enhancement, peak focusing position and peak focusing width are in good agreement with experimental measurements, validating the model. The predicted separation of yellow/red (R-PE) from green (Dyl-Strep) fluorescent proteins mimics that from a previous experiment [Inglis et al., Angew. Chem. Int. Ed., 2011, 50, 7546] conducted in a slightly different geometry. The results will inform the design of new class of matrix-free particle focusing and separation devices.

  9. Dual-channel active laser detection system%双通道激光主动探测系统

    Institute of Scientific and Technical Information of China (English)

    刘秉琦; 周斌; 武东生; 张瑜

    2012-01-01

    A dual-channel active laser detection system based on an Avalanche Photo Diode(APD) and a Charge-couple Device(CCD) is designed to effectively detect weak echo signals of "cat-eye" targets and to acquire the intuitive image information of a target area. Firstly, the concept of hardware design is introduced, including the functions and constitution of some modulies and the types of primary assemblies. Then,based on the key problems of designing receiving-magnifying circuit in the APD detection mode, the circuit constitution, working principle and the selection of main parts are discussed,and the match of response spectrum for the CCD and laser is analyzed. Finally, the detection experiments are performed by using typical "cat-eye" targets at different distances. The experimental results show that the echo signal power of the typical "cat-eye" target is 2. 87 times that of mirror-like surface at a distance of 550 m in the APD mode; and the echo signal power of a telescope and that of optical window for a laser finder are 2. 72 times and 2. 31 times those of background at distances of 550 m and 2 500 m in the CCD mode,respectively. The dual-channel active laser detection system can capture the "cat-eye" targets from background and jamming targets easily, which proves the rationality and validity of the proposed system.%为了有效探测“猫眼”目标的微弱回波信号并获得目标区域的直观图像信息,设计了基于雪崩光电二极管(APD)单元探测器和电荷耦合器件(CCD)面阵探测器的双通道激光主动探测系统.介绍了硬件设计的基本思路,包括各模块功能、组成和主要部件所采用的型号.针对双通道探测模式的关键技术,阐述了APD探测模式下接收放大电路的设计方法,并分析了CCD探测模式下响应波长的匹配问题.最后,在外场条件下,利用望远镜和激光测距机等典型“猫眼”目标对该双通道激光主动探测系统进行了实验验证.实验结果表

  10. A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots.

    Science.gov (United States)

    Huang, Yuanyuan; Zhou, Jin; Feng, Hui; Zheng, Jieyu; Ma, Hui-Min; Liu, Weidong; Tang, Cong; Ao, Hang; Zhao, Meizhi; Qian, Zhaosheng

    2016-12-15

    A convenient, fluorescent dual-channel chemosensor on the basis of bis(3-pyridylmethyl)amine-functionalized carbon quantum dots (BPMA-CQDs) nanoprobe was constructed, and it can discriminatively detect glutathione from its analogues cysteine and homocysteine based on two distinctive strategies. Two distinct fluorescence responses of BPMA-CQDs probe to Cu(II) and Ag(I) were identified and further employed to achieve selective detection of Cu(II) and Ag(I) respectively. Based on the BPMA-CQDs/Cu(II) conjugate, discriminative detection of GSH was achieved in terms of correlation between the amounts of GSH and fluorescence recovery. The addition of GSH into BPMA-CQDs/Cu(II) system induces the reduction of Cu(II) to Cu(I), which could efficiently block PET process resulting in the following fluorescence recovery. Based on the BPMA-CQDs/Ag(I) conjugate, GSH assay could also be established on the basis of fluorescence response to GSH. The introduction of GSH into the preceding system triggers the competitive coordination to Ag(I) between BPMA and GSH, and silver ions are finally taken away by GSH from the probe, where the fluorescence is restored to its original weak state. Both of the detection strategies can achieve discriminative detection of GSH from Cys and Hcy. The assays showed good stability and repeatability, and covered a broad linear range of up to 13.3μM with a lowest detection limit of 42.0nM. Moreover, both of them were utilized to monitor GSH level in live cells.

  11. A 200-Channel Area-Power-Efficient Chemical and Electrical Dual-Mode Acquisition IC for the Study of Neurodegenerative Diseases.

    Science.gov (United States)

    Guo, Jing; Ng, Waichiu; Yuan, Jie; Li, Suwen; Chan, Mansun

    2016-06-01

    Microelectrode array (MEA) can be used in the study of neurodegenerative diseases by monitoring the chemical neurotransmitter release and the electrical potential simultaneously at the cellular level. Currently, the MEA technology is migrating to more electrodes and higher electrode density, which raises power and area constraints on the design of acquisition IC. In this paper, we report the design of a 200-channel dual-mode acquisition IC with highly efficient usage of power and area. Under the constraints of target noise and fast settling, the current channel design saves power by including a novel current buffer biased in discrete time (DT) before the TIA (transimpedance amplifier). The 200 channels are sampled at 20 kS/s and quantized by column-wise SAR ADCs. The prototype IC was fabricated in a 0.18 μm CMOS process. Silicon measurements show the current channel has 21.6 pArms noise with cyclic voltammetry (CV) and 0.48 pArms noise with constant amperometry (CA) while consuming 12.1 μW . The voltage channel has 4.07 μVrms noise in the bandwidth of 100 kHz and 0.2% nonlinearity while consuming 9.1 μW. Each channel occupies 0.03 mm(2) area, which is among the smallest.

  12. Practical Dual WiFi NIC and Multi-channel MAC Protocol%双网卡多信道无线MAC协议

    Institute of Scientific and Technical Information of China (English)

    赵蕴龙; 康世龙; 高振国; 杨飞

    2012-01-01

    多收发器多信道技术能够有效提高无线多跳网络的带宽和吞吐量,成为学术界的研究热点.多收发器多信道MAC协议研究主要涉及信道资源的分配与管理问题.在现有多信道MAC协议的研究基础上,提出一种基于IEEE802.11标准WiFi网卡的双收发器多信道MAC协议-DIM( Dual-Interface Management).协议采用信道冲突模型来分配信道资源,以优化网络的信道分布;同时,DIM协议在较少的硬件配置下,充分利用IEEE802.11标准提供的信道资源,提高了信道利用率.仿真实验表明,DIM协议具有较大的网络吞吐量和较小的分组传输延迟.%Multi-radio multi-channel technology can efficiently improve the multi-hop wireless networks' bandwidth and throughput, so that it has been becoming the researching hot spot. Among the so many researching key issues about the multi-radio multi-channel technology, wireless channel assignment and management are more important and difficult. This paper proposed a new dual-radio multi-channel MAC protocol using the standard 802. 11 WiFi NIC, named as DIM (Dual-Interface Management MAC protocol). DIM can optimize the channel assignment by applying the channel conflict model,and take full use of the available IEEE802. 11 wireless channels with little command on hardwire configuration. The simulation rtsults show that DIM has more network throughput and less latency of packets delivery.

  13. Evaluation of Different Holder Devices for Freeze-Drying in Dual-Chamber Cartridges With a Focus on Energy Transfer.

    Science.gov (United States)

    Korpus, Christoph; Friess, Wolfgang

    2017-04-01

    For freeze-drying in dual-chamber cartridges, a holder device to enable handling and safe positioning in the freeze-dryer is necessary. The aim of this study was to analyze 4 different types of holder devices and to define the best system based on energy transfer. The main criteria were drying homogeneity, ability to minimize the influence of atypical radiation on product temperatures, and heat transfer effectiveness. The shell holder reduced the influence of atypical radiation by almost 60% compared to a block system and yielded the most homogenous sublimation rates. Besides the most efficient heat transfer with values of 1.58E-4 ± 2.06E-6 cal/(s*cm(2)*K) at 60 mTorr to 3.63E-4 ± 1.85E-5 cal/(s*cm(2)*K) at 200 mTorr for Ktot, reaction times to shelf temperature changes were up to 4 times shorter compared to the other holder systems and even faster than for vials. The flexible holder provided a comparable shielding against atypical radiation as the shell but introduced a third barrier against energy transfer. Block and guardrail holder were the least efficient system tested. Hence, the shell holder provided the best radiation shielding, enhanced the transferability of the results to a larger scale, and improved the homogeneity between the dual-chamber cartridges.

  14. 存在差异性产品的双渠道供应链协调研究%Coordination of Dual-channel Supply Chain under Product Differentiation

    Institute of Scientific and Technical Information of China (English)

    陈远高; 刘南

    2011-01-01

    研究存在差异性产品条件下,网络直销渠道与传统零售渠道并存的双渠道供应链系统的协调问题.分别建立了存在单一产品的双渠道供应链需求模型和存在两种差异性产品的双渠道供应链需求模型,并分析了两种情形下供应链最优协调策略,最后进行了算例分析,探讨了网络渠道接受程度、产品差异性程度参数对于供应链及其成员利润的影响.结果表明,双渠道供应链中差异化产品的引入将导致供应链系统利润减少,但更高的产品差异程度能够给Stackelberg博弈占优的制造商带来更高的利润.%E-business success in satisfying customers depends on the support of supply chain networks. By adopting dual-channel supply chains and Internet marketing, companies can increase customer demand, attract new customers, and enter new markets by lowering operational costs and reducing product prices. Previous studies examined pricing strategies and contract coordination in dualchannel supply chains. These studies were executed based on the assumption that all products in dual-channels are homogeneous.Therefore, the single product model cannot help illustrate competition complexity in dual-channel supply chains. This research overcomes the weakness of previous studies by using dual-channel demand model for two different products. We consider a dualchannel supply chain consisting of a manufacturer and a retailer. We assume that a manufacturer sells a single product via its retailers' traditional channels and Internet direct channels. Retailers purchase another heterogeneous product from other sales providers.In the first part, we presented two different demand models of a dual-channel supply chain with a single product and two various products. A customer's channel choice decisions depend on three major factors including product price, channel service and Internet acceptance. The feasible product pricing region of Internet channels and retailer

  15. A 160 kJ dual plasma focus (DuPF) for fusion-relevant materials testing and nano-materials fabrication

    Science.gov (United States)

    Saw, S. H.; Damideh, V.; Chong, P. L.; Lee, P.; Rawat, R. S.; Lee, S.

    2014-08-01

    This paper summarizes PF-160 Dual Plasma Focus (DuPF) numerical experiments using the Lee Model code and preliminary 3D design drawings using SolidWorks software. This DuPF consists of two interchangeable electrodes enabling it to be optimized for both Slow Pinch Mode (SFM) and Fast Pinch Mode (FFM); the latter using a speed factor (SF) of 90 kA cm-1 Torr-0.5 for FFM in deuterium [S Lee et al, IEEE Trans Plasma Science 24, 1101-1105 (1996)]; and the former with SF of less than half that value for SFM. Starting with available 6 × 450 µF capacitors rated at 11kV (10% reversal), numerical experiments indicate safe operation at 9 kV, 6 Torr deuterium with FFM anode of 5 cm radius; producing intense ion beam and streaming plasma pulses which would be useful for studies of potential fusion reactor wall materials. On the other hand operating at 5 kV, 10 Torr deuterium with SFM anode of 10 cm radius leads to long-duration, uniform large-area flow which could be more suitable for synthesis of nano-materials. The dual plasma focus design is illustrated here with two figures showing FFM and SFM electrodes.

  16. A Strategic Design of an Opto-Chemical Security Device with Resettable and Reconfigurable Password Based Upon Dual Channel Two-in-One Chemosensor Molecule

    Science.gov (United States)

    Majumdar, Tapas; Haldar, Basudeb; Mallick, Arabinda

    2017-02-01

    A simple strategy is proposed to design and develop an intelligent device based on dual channel ion responsive spectral properties of a commercially available molecule, harmine (HM). The system can process different sets of opto-chemical inputs generating different patterns as fluorescence outputs at specific wavelengths which can provide an additional level of protection exploiting both password and pattern recognitions. The proposed system could have the potential to come up with highly secured combinatorial locks at the molecular level that could pose valuable real time and on-site applications for user authentication.

  17. Formation of Tunable, Emulsion Micro-Droplets Utilizing Flow-Focusing Channels and a Normally-Closed Micro-Valve

    Directory of Open Access Journals (Sweden)

    Gwo-Bin Lee

    2013-07-01

    Full Text Available A mono-dispersed emulsion is of great significance in many chemical, biomedical and industrial applications. The current study reports a new microfluidic chip capable of forming tunable micro-droplets in liquids for emulsification applications. It can precisely generate size-tunable, uniform droplets using flow-focusing channels and a normally-closed valve, which is opened by a pneumatic suction force. Experimental data showed that micro-droplets with a diameter ranging from several to tens of micrometers could be precisely generated with a high uniformity. The droplet size is experimentally found to be dependent on the velocity of the dispersed-phase liquid, which is controlled by the deflection of the suction membrane. Emulsions with droplet sizes ranging from 5.5 to 55 μm are successfully observed. The variation in droplet sizes is from 3.8% to 2.5%. The micro-droplets have a uniform size and droplets smaller than those reported in previous studies are possible with this approach. This new microfluidic device can be promising for emulsification and other related applications.

  18. Dual-channel detection of metallothioneins and mercury based on a mercury-mediated aptamer beacon using thymidine-mercury-thymidine complex as a quencher.

    Science.gov (United States)

    Chen, Si-Han; Wang, Yong-Sheng; Chen, Yun-Sheng; Tang, Xian; Cao, Jin-Xiu; Li, Ming-Hui; Wang, Xiao-Feng; Zhu, Yu-Feng; Huang, Yan-Qin

    2015-01-01

    A novel dual-channel strategy for the detection of metallothioneins (MTs) and Hg(2+) has been developed based on a mercury-mediated aptamer beacon (MAB) using thymidine-mercury-thymidine complex as a quencher for the first time. In the presence of Hg(2+), the T-rich oligonucleotide with a 6-carboxyfluorescein (TRO-FAM) can form an aptamer beacon via the formation of T-Hg(2+)-T base pairs, which results in a fluorescence quenching of the sensing system owing to the fluorescence resonance energy transfer (FRET) from the fluorophore of FAM to the terminated T-Hg(2+)-T base pair. The addition of MTs into this solution leads to the disruption of the T-Hg(2+)-T complex, resulting in an increase of the fluorescent signal of the system. In the optimizing condition, ΔF was directly proportional to the concentrations ranging from 5.63 nM to 0.275 μM for MTs, and 14.2 nM to 0.30 μM for Hg(2+) with the detection limits of 1.69 nM and 4.28 nM, respectively. The proposed dual-channel method avoids the label steps of a quencher in common molecular beacon strategies, without tedious procedure or the requirement of sophisticated equipment, and is rapid, inexpensive and sensitive.

  19. Study and Simulation on Dynamics of a Risk-Averse Supply Chain Pricing Model with Dual-Channel and Incomplete Information

    Science.gov (United States)

    Sun, Lijian; Ma, Junhai

    Under the industrial background of dual-channel, volatility in demand of consumers, we use the theory of bifurcations and numerical simulation tools to investigate the dynamic pricing game in a dual-channel supply chain with risk-averse behavior and incomplete information. Due to volatility of demand of consumers, we consider all the players in the supply chain are risk-averse. We assume there exist Bertrand game and Manufacturers’ Stackelberg in the chain which are closer to reality. The main objective of the paper is to investigate the complex influence of the decision parameters such as wholesale price adjustment speed, risk preference and service value on stability of the risk-averse supply chain and average utilities of all the players. We lay emphasis on the influence of chaos on average utilities of all the players which did not appear in previous studies. The dynamic phenomena, such as the bifurcation, chaos and sensitivity to initial values are analyzed by 2D bifurcation phase portraits, Double Largest Lyapunov exponent, basins of attraction and so on. The study shows that the manufacturers should slow down their wholesale price adjustment speed to get more utilities, if the manufacturers are willing to take on more risk, they will get more profits, but they must keep their wholesale prices in a certain range in order to maintain the market stability.

  20. Independent Control of Ion Transmission in a Jet Disrupter Dual-Channel Ion Funnel Electrospray Ionization MS Interface

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Keqi; Tolmachev, Aleksey V.; Nikolaev, E. N.; Zhang, Rui; Belov, Mikhail E.; Udseth, Harold R.; Smith, Richard D.

    2002-09-17

    While the use of an internal calibrant can significantly increase mass measurement accuracy in many LC-MS applications, ion suppression in the ESI process and space charge effects in the MS analyzer often limit its effectiveness. These limitations are especially problematic when LC-MS is used for analyzing complex biological samples where both high sensitivity and broad dynamic range are required. To address this need, a new ESI interface has been developed to control ion transmission through the first vacuum stage of the mass spectrometer. The initial design using a dual electrospray, a dual heated capillary and a dual inlet ion funnel (Fig. 1) is specifically aimed at providing a method for controlled introduction of calibrant ions in highly accurate mass measurements using Fourier transform ion cyclotron resonance mass spectrometer.

  1. Magnetic field sensitivity at 7-T using dual-helmholtz transmit-only coil and 12-channel receive-only bended coil.

    Science.gov (United States)

    Kim, Kyoung-Nam; Ryu, Yeunchul; Seo, Jeung-Hoon; Kim, Young-Bo

    2016-11-01

    The purpose of this study was to combine a dual-Helmholtz (DH) transmit (Tx)-only coil and 12-channel receive (Rx)-only bended phased array (PA) coil to improve the magnetic flux (|B1 |) sensitivity in the superior-to-inferior (S-I) direction during human brain magnetic resonance imaging (MRI) at 7-T. The proposed coil combination was primarily implemented by electromagnetic (EM) simulation and compared with the 16-leg birdcage coil and 8-channel PA coil, which are generally used for the Tx- and Rx-only modes, respectively. The optimal coil combinations for the proposed structure were determined by |B1 | field calculations using the |BT(+) | and |BR(-) | fields, which are respectively the transmit and receive components of the |B1 | field. The coil performance was then evaluated by a bench test and 7-T MRI experiment. The results of the computational calculations indicated that the |BT(+) | field of the DH coil was distributed similarly to that of the 16-leg birdcage coil despite the fewer conducting legs of the former. However, the 12-channel Rx-only bended PA coil had clearly higher |BR(-) | profiles compared to the 8-channel PA coil. The results of the 7-T in vivo experiment showed that the proposed combination of the DH Tx-only coil and 12-channel Rx-only bended PA coil had better |B1 | field homogeneity in the sagittal slice as well as higher |B1 | field sensitivity during human brain MRI compared to an 8-channel Rx-only PA coil. SCANNING 38:515-524, © 2015 Wiley Periodicals, Inc.

  2. Design optimization of the proximity focusing RICH with dual aerogel radiator using a maximum-likelihood analysis of Cherenkov rings

    Science.gov (United States)

    Pestotnik, R.; Križan, P.; Korpar, S.; Iijima, T.

    2008-09-01

    The use of a sequence of aerogel radiators with different refractive indices in a proximity focusing Cherenkov ring imaging detector has been shown to improve the resolution of the Cherenkov angle. In order to obtain further information on the capabilities of such a detector, a maximum-likelihood analysis has been performed on simulated data, with the simulation being appropriate for the upgraded Belle detector. The results show that by using a sequence of two aerogel layers with different refractive indices, the K/π separation efficiency is improved in the kinematic region above 3 GeV/ c. In the low momentum region, the focusing configuration (with n1 and n2 chosen such that the Cherenkov rings from different aerogel layers at 4 GeV/ c overlap) shows a better performance than the defocusing one (where the two Cherenkov rings are well separated).

  3. Protein-directed synthesis of Mn-doped ZnS quantum dots: a dual-channel biosensor for two proteins.

    Science.gov (United States)

    Wu, Peng; Zhao, Ting; Tian, Yunfei; Wu, Lan; Hou, Xiandeng

    2013-06-03

    Proteins typically have nanoscale dimensions and multiple binding sites with inorganic ions, which facilitates the templated synthesis of nanoparticles to yield nanoparticle-protein hybrids with tailored functionality, water solubility, and tunable frameworks with well-defined structure. In this work, we report a protein-templated synthesis of Mn-doped ZnS quantum dots (QDs) by exploring bovine serum albumin (BSA) as the template. The obtained Mn-doped ZnS QDs give phosphorescence emission centered at 590 nm, with a decay time of about 1.9 ms. A dual-channel sensing system for two different proteins was developed through integration of the optical responses (phosphorescence emission and resonant light scattering (RLS)) of Mn-doped ZnS QDs and recognition of them by surface BSA phosphorescent sensing of trypsin and RLS sensing of lysozyme. Trypsin can digest BSA and remove BSA from the surface of Mn-doped ZnS QDs, thus quenching the phosphorescence of QDs, whereas lysozyme can assemble with BSA to lead to aggregation of QDs and enhanced RLS intensity. The detection limits for trypsin and lysozyme were 40 and 3 nM, respectively. The selectivity of the respective channel for trypsin and lysozyme was evaluated with a series of other proteins. Unlike other protein sensors based on nanobioconjugates, the proposed dual-channel sensor employs only one type of QDs but can detect two different proteins. Further, we found the RLS of QDs can also be useful for studying the BSA-lysozyme binding stoichiometry, which has not been reported in the literature. These successful biosensor applications clearly demonstrate that BSA not only serves as a template for growth of Mn-doped ZnS QDs, but also impacts the QDs for selective recognition of analyte proteins.

  4. Wavefront-correction for nearly diffraction-limited focusing of dual-color laser beams to high intensities.

    Science.gov (United States)

    Zhao, Baozhen; Zhang, Jun; Chen, Shouyuan; Liu, Cheng; Golovin, Grigory; Banerjee, Sudeep; Brown, Kevin; Mills, Jared; Petersen, Chad; Umstadter, Donald

    2014-11-03

    We demonstrate wavefront correction of terawatt-peak-power laser beams at two distinct and well-separated wavelengths. Simultaneous near diffraction-limited focusability is achieved for both the fundamental (800 nm) and second harmonic (400 nm) of Ti:sapphire-amplified laser light. By comparing the relative effectiveness of various correction loops, the optimal ones are found. Simultaneous correction of both beams of different color relies on the linear proportionality between their wavefront aberrations. This method can enable two-color experiments at relativistic intensities.

  5. Hot-electron real-space transfer and longitudinal transport in dual AlGaN/AlN/{AlGaN/GaN} channels

    Science.gov (United States)

    Šermukšnis, E.; Liberis, J.; Matulionis, A.; Avrutin, V.; Ferreyra, R.; Özgür, Ü.; Morkoç, H.

    2015-03-01

    Real-space transfer of hot electrons is studied in dual-channel GaN-based heterostructure operated at or near plasmon-optical phonon resonance in order to attain a high electron drift velocity at high current densities. For this study, pulsed electric field is applied in the channel plane of a nominally undoped Al0.3Ga0.7N/AlN/{Al0.15Ga0.85N/GaN} structure with a composite channel of Al0.15Ga0.85N/GaN, where the electrons with a sheet density of 1.4 × 1013 cm-2, estimated from the Hall effect measurements, are confined. The equilibrium electrons are situated predominantly in the Al0.15Ga0.85N layer as confirmed by capacitance-voltage experiment and Schrödinger-Poisson modelling. The main peak of the electron density per unit volume decreases as more electrons occupy the GaN layer at high electric fields. The associated decrease in the plasma frequency induces the plasmon-assisted decay of non-equilibrium optical phonons (hot phonons) confirmed by the decrease in the measured hot-phonon lifetime from 0.95 ps at low electric fields down below 200 fs at fields of E \\gt 4 kV cm-1 as the plasmon-optical phonon resonance is approached. The onset of real-space transfer is resolved from microwave noise measurements: this source of noise dominates for E \\gt 8 kV cm-1. In this range of fields, the longitudinal current exceeds the values measured for a mono channel reference Al0.3Ga0.7N/AlN/GaN structure. The results are explained in terms of the ultrafast decay of hot phonons and reduced alloy scattering caused by the real-space transfer in the composite channel.

  6. Real-time monitoring of focused ultrasound blood-brain barrier opening via subharmonic acoustic emission detection: implementation of confocal dual-frequency piezoelectric transducers.

    Science.gov (United States)

    Tsai, Chih-Hung; Zhang, Jia-Wei; Liao, Yi-Yi; Liu, Hao-Li

    2016-04-07

    Burst-tone focused ultrasound exposure in the presence of microbubbles has been demonstrated to be effective at inducing temporal and local opening of the blood-brain barrier (BBB), which promises significant clinical potential to deliver therapeutic molecules into the central nervous system (CNS). Traditional contrast-enhanced imaging confirmation after focused ultrasound (FUS) exposure serves as a post-operative indicator of the effectiveness of FUS-BBB opening, however, an indicator that can concurrently report the BBB status and BBB-opening effectiveness is required to provide effective feedback to implement this treatment clinically. In this study, we demonstrate the use of subharmonic acoustic emission detection with implementation on a confocal dual-frequency piezoelectric ceramic structure to perform real-time monitoring of FUS-BBB opening. A confocal dual-frequency (0.55 MHz/1.1 MHz) focused ultrasound transducer was designed. The 1.1 MHz spherically-curved ceramic was employed to deliver FUS exposure to induce BBB-opening, whereas the outer-ring 0.55 MHz ceramic was employed to detect the subharmonic acoustic emissions originating from the target position. In stage-1 experiments, we employed spectral analysis and performed an energy spectrum density (ESD) calculation. An optimized 0.55 MHz ESD level change was shown to effectively discriminate the occurrence of BBB-opening. Wideband acoustic emissions received from 0.55 MHz ceramics were also analyzed to evaluate its correlations with erythrocyte extravasations. In stage-2 real-time monitoring experiments, we applied the predetermined ESD change as a detection threshold in PC-controlled algorithm to predict the FUS exposure intra-operatively. In stage-1 experiment, we showed that subharmonic ESD presents distinguishable dynamics between intact BBB and opened BBB, and therefore a threshold ESD change level (5.5 dB) can be identified for BBB-opening prediction. Using this ESD change threshold detection as a

  7. Real-time monitoring of focused ultrasound blood-brain barrier opening via subharmonic acoustic emission detection: implementation of confocal dual-frequency piezoelectric transducers

    Science.gov (United States)

    Tsai, Chih-Hung; Zhang, Jia-Wei; Liao, Yi-Yi; Liu, Hao-Li

    2016-04-01

    Burst-tone focused ultrasound exposure in the presence of microbubbles has been demonstrated to be effective at inducing temporal and local opening of the blood-brain barrier (BBB), which promises significant clinical potential to deliver therapeutic molecules into the central nervous system (CNS). Traditional contrast-enhanced imaging confirmation after focused ultrasound (FUS) exposure serves as a post-operative indicator of the effectiveness of FUS-BBB opening, however, an indicator that can concurrently report the BBB status and BBB-opening effectiveness is required to provide effective feedback to implement this treatment clinically. In this study, we demonstrate the use of subharmonic acoustic emission detection with implementation on a confocal dual-frequency piezoelectric ceramic structure to perform real-time monitoring of FUS-BBB opening. A confocal dual-frequency (0.55 MHz/1.1 MHz) focused ultrasound transducer was designed. The 1.1 MHz spherically-curved ceramic was employed to deliver FUS exposure to induce BBB-opening, whereas the outer-ring 0.55 MHz ceramic was employed to detect the subharmonic acoustic emissions originating from the target position. In stage-1 experiments, we employed spectral analysis and performed an energy spectrum density (ESD) calculation. An optimized 0.55 MHz ESD level change was shown to effectively discriminate the occurrence of BBB-opening. Wideband acoustic emissions received from 0.55 MHz ceramics were also analyzed to evaluate its correlations with erythrocyte extravasations. In stage-2 real-time monitoring experiments, we applied the predetermined ESD change as a detection threshold in PC-controlled algorithm to predict the FUS exposure intra-operatively. In stage-1 experiment, we showed that subharmonic ESD presents distinguishable dynamics between intact BBB and opened BBB, and therefore a threshold ESD change level (5.5 dB) can be identified for BBB-opening prediction. Using this ESD change threshold detection as a

  8. HAI, a new airborne, absolute, twin dual-channel, multi-phase TDLAS-hygrometer: background, design, setup, and first flight data

    Science.gov (United States)

    Buchholz, Bernhard; Afchine, Armin; Klein, Alexander; Schiller, Cornelius; Krämer, Martina; Ebert, Volker

    2017-01-01

    The novel Hygrometer for Atmospheric Investigation (HAI) realizes a unique concept for simultaneous gas-phase and total (gas-phase + evaporated cloud particles) water measurements. It has been developed and successfully deployed for the first time on the German HALO research aircraft. This new instrument combines direct tunable diode laser absorption spectroscopy (dTDLAS) with a first-principle evaluation method to allow absolute water vapor measurements without any initial or repetitive sensor calibration using a reference gas or a reference humidity generator. HAI contains two completely independent dual-channel (closed-path, open-path) spectrometers, one at 1.4 and one at 2.6 µm, which together allow us to cover the entire atmospheric H2O range from 1 to 40 000 ppmv with a single instrument. Both spectrometers each comprise a separate, wavelength-individual extractive, closed-path cell for total water (ice and gas-phase) measurements. Additionally, both spectrometers couple light into a common open-path cell outside of the aircraft fuselage for a direct, sampling-free, and contactless determination of the gas-phase water content. This novel twin dual-channel setup allows for the first time multiple self-validation functions, in particular a reliable, direct, in-flight validation of the open-path channels. During the first field campaigns, the in-flight deviations between the independent and calibration-free channels (i.e., closed-path to closed-path and open-path to closed-path) were on average in the 2 % range. Further, the fully autonomous HAI hygrometer allows measurements up to 240 Hz with a minimal integration time of 1.4 ms. The best precision is achieved by the 1.4 µm closed-path cell at 3.8 Hz (0.18 ppmv) and by the 2.6 µm closed-path cell at 13 Hz (0.055 ppmv). The requirements, design, operation principle, and first in-flight performance of the hygrometer are described and discussed in this work.

  9. Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels.

    Science.gov (United States)

    Du, Yuzhe; Nomura, Yoshiko; Zhorov, Boris S; Dong, Ke

    2016-02-26

    1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), the first organochlorine insecticide, and pyrethroid insecticides are sodium channel agonists. Although the use of DDT is banned in most of the world due to its detrimental impact on the ecosystem, indoor residual spraying of DDT is still recommended for malaria control in Africa. Development of resistance to DDT and pyrethroids is a serious global obstacle for managing disease vectors. Mapping DDT binding sites is necessary for understanding mechanisms of resistance and modulation of sodium channels by structurally different ligands. The pioneering model of the housefly sodium channel visualized the first receptor for pyrethroids, PyR1, in the II/III domain interface and suggested that DDT binds within PyR1. Previously, we proposed the second pyrethroid receptor, PyR2, at the I/II domain interface. However, whether DDT binds to both pyrethroid receptor sites remains unknown. Here, using computational docking of DDT into the Kv1.2-based mosquito sodium channel model, we predict that two DDT molecules can bind simultaneously within PyR1 and PyR2. The bulky trichloromethyl group of each DDT molecule fits snugly between four helices in the bent domain interface, whereas two p-chlorophenyl rings extend into two wings of the interface. Model-driven mutagenesis and electrophysiological analysis confirmed these propositions and revealed 10 previously unknown DDT-sensing residues within PyR1 and PyR2. Our study proposes a dual DDT-receptor model and provides a structural background for rational development of new insecticides.

  10. Dual-channel Cloud Data Storage Security Scheme%双通道云数据存储安全方案研究

    Institute of Scientific and Technical Information of China (English)

    熊毅

    2012-01-01

    为了改善解决云计算中热点问题之一—数据存储安全,该文在研究现有经典云数据存储体系架构的基础上,根据云本身的超强计算能力和代价低廉等特性,提出了一种优化的双通道并行云存储架构,配以非对称数据加密手段,在硬件与架构层面直接针对安全问题作出优化部署.在大量的节约成本、提高效率、精简架构的情况下保证了云环境下数据存储安全性的提升.模拟部署表明,双通道并行云架构及非对称数据加密能有效的提高云数据存储的安全性.%In order to improve the resolution of cloud computing in the hot one of the issues-the security of data storage, the author based on the study of existing classic cloud data storage architecture, according to the characteristics of cloud super computing power and cost of low, propose an optimized dual-channel parallel cloud storage architecture,together with the non-symmetric data encryption,optimize the deployment of security issues made in the level of hardware and architecture. The security of data storage in the cloud environment is enhanced with a lot of cost savings, improve efficiency and streamlining. Simulated deployment, dual-channel parallel cloud structure and non-symmetric data encryption can effectively improve the security of the cloud data storage.

  11. Coordination Mechanisms Based on Strategic Innovative Compensation in Dual-Channel Supply Chains%考虑创新补偿的双渠道供应链协调机制研究

    Institute of Scientific and Technical Information of China (English)

    陈树桢; 熊中楷; 李根道; 文海鸿

    2011-01-01

    电子商务环境下,以创新降低物流、库存等分销成本是零售商赢得生存与发展的重要途径;在渠道和谐与利润最大化驱使下,策略性创新补偿成为制造商的首选策略.本文在传统分销与在线直销价格竞争下,构建模型并研究了上述双渠道供应链的协调问题.研究发现,单独利用创新补偿能实现制造商与零售商收益的Pareto改进,却无法达到供应链整体最优,设计了使渠道协调的两部定价合同.%The growing acceptance of third-party logistics service providers to cope with the rapid expansion of e-business is encouraging many manufacturers to engage in the direct sales business. As a result, the dual channel model is becoming increasingly popular. While the dual channel model has its advantages, a manufacturer may become a direct competitor to its sourcing partners.This paper investigates channel conflict issues caused by the dual channel model and approaches to alleviate these issues so that both manufacturers and retailers can benefit from the new trend.The goal of this paper is to provide managerial insights on channel conflict issues caused by the dual channel model. In order to achieve this goal, this paper analyzes these issues by developing a simulation game to represent a two-echelon dual-channel model.This model incorporates key attributes related to the relationships between manufacturers and retailers. They act independently based on price competition between the online direct and traditional channels. We also take into account the fact that manufacturers and retailers need to coordinate sales channels. In the dual-channel model, retailers in the lower echelon need to try reducing logistics/inventory operating costs besides changing pricing policy in order to stay competitive. In response to retailers' strategic changes, their manufacturers need to ensure that online direct sales and traditional sales channels coexist in order to cope with new strategic

  12. 考虑渠道偏好的双渠道供应链库存策略研究%Study on Dual Channel Supply Chain Inventory Strategy with Channel Preference

    Institute of Scientific and Technical Information of China (English)

    李莉; 刘欣; 颜艳

    2013-01-01

    制造商同时开展在线直销和传统分销时,需要有效地协调双渠道之间可能存在的物流冲突问题.以双渠道供应链系统为研究对象,在考虑消费者渠道选择偏好的前提下,构建了库存决策定量模型并进行最优性分析.在此基础上,运用Matlab软件对模型进行了算例分析.结果表明,随着需求不确定性的增大,制造商和零售商均增加库存且利润受损,而在线渠道偏好率的增大将导致制造商库存量增大、零售商和供应链的利润受损.%When conducting both online sale and conventional retail,manufacturers need to coordinate the logistics conflict between these two channels.In considering consumer channel preference,the dual channel supply chain system is analyzed and an inventory decision-making quantitative model is built.Based on this model,simulation is made by using Matlab.Results indicate that as demand uncertainty increases,manufacturers and retailers increase their inventory and suffer a loss of profit,while the increase of online channel preference rate can result manufacturers' inventory increase,which results in the profit decrease of retailers and the supply chain.

  13. High Spectrum Narrowing Tolerant 112 Gb/s Dual Polarization QPSK Optical Communication Systems Using Digital Adaptive Channel Estimation

    DEFF Research Database (Denmark)

    Zhang, Xu; Pang, Xiaodan; Dogadaev, Anton Konstantinovich;

    2012-01-01

    We experimentally demonstrate high spectrum narrowing tolerant 112-Gb/s QPSK polarization multiplex system based on digital adaptive channel estimation method. The proposed algorithm is able to detect severe spectrum-narrowed signal even with 20GHz 3dB bandwidth....

  14. Analysis of vortical structure over sinusoidal riblet surface in turbulent channel flow by means of Dual-plane stereoscopic PIV measurement

    Science.gov (United States)

    Mamori, Hiroya; Yamaguchi, Kyotaro; Sasamori, Monami; Iwamoto, Kaoru; Murata, Akira

    2016-11-01

    We perform a dual-plane stereoscopic particle image velocimetry (DPS-PIV) measurement to investigate vortical structure over a sinusoidal riblet surface in the turbulent channel flow. In the sinusoidal riblet surface, its lateral spacing of the adjacent walls varies in the streamwise direction and 12% of the drag reduction rate has been confirmed in the turbulent channel flow. The DPS-PIV measurement system consists of four high-speed CCD cameras and the two laser sheets. In the flat case, the profile of the velocity statistics shows a good agreement with previous data. In the ribet case, the velocity statistics decrease in the region close to the wall as compared with that of the flat case. Since all velocity components are measured on adjacent laser sheets simultaneously, vortical structures can be obtained by a second invariant of the tensor i.e. the Q value. According to an analysis for the Q value, we found that the vortical structure is shifted up and attenuated owing to the riblet. Moreover, the riblet prevents the approaching of the vortical structure: the upward and downward flows in the region near the wall are generated by the riblet; if the vortical structure approaches the wall, it is shifted away from the wall due to the upward flow.

  15. Efficacy and safety of calcium channel blockers in heart failure : Focus on recent trials with second-generation dihydropyridines

    NARCIS (Netherlands)

    de Vries, RJM; van Veldhuisen, DJ; Dunselman, PHJM

    2000-01-01

    Background Chronic heart failure (CHF) has high morbidity and mortality rates despite treatment with angiotensin-converting-enzyme inhibitors, diuretics, and digoxin. Adjunctive-vasodilation through calcium channel blockade has been suggested as potentially useful, However, the first-generation calc

  16. An ASIC design for versatile receive front-end electronics of an ultrasonic medical imaging system--16 channel analog inputs and 4 dynamically focused beam outputs.

    Science.gov (United States)

    Park, Song B; Kwak, Jaeyoung; Lee, Kwyro

    2003-04-01

    An ultra large-scale ASIC is designed for the receive front-end electronics of an ultrasonic medical imaging system. The chip receives 16 channel analog rf signals and outputs 4 sets of sample-point-wise dynamically focused partial beam data. Four complete beam data sets are obtained in parallel by simply cascading as many chips as needed in an array system. High resolution of the focusing delay is obtained by nonuniformly selecting each channel data from a quadruply-interpolated rf data stream. The proposed ASIC can be applied to most practical array transducers in the frequency range of 2 to 10 MHz. The digital part of the designed ASIC can be implemented on a chip area of 17.9 microm2 with 0.18 mm CMOS technology, leaving sufficient room for 16 ADCs of 8 bits, 50 MHz on the 5.7 mm x 5.7 mm chip with a 208 pin package.

  17. Synthesis and Effects of Novel Dihydropyridines as Dual Calcium Channel Blocker and Angiotensin Antagonist on Isolated Rat Aorta

    Directory of Open Access Journals (Sweden)

    Farzin Hadizadeh

    2010-01-01

    Full Text Available Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT1 and L-type calcium channels were investigated on isolated rat aorta. Materials and MethodsAortic rings were pre-contracted with 1 µM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and 5b were evaluated by cumulative addition of these drugs to the bath solution.ResultsThe results showed that compounds 5a and 5b have both L-type calcium channel and AT1 receptor blocking activity. Their effects on AT1 receptors are 1000 and 100,000 times more than losartan respectively. The activity of compound 5b on L-type calcium channel is significantly less than nifedipine but compound 5a has comparable effect with nifedipine. ConclusionFinally we concluded that these two new Compounds can be potential candidates to be used as effective antihypertensive agents.

  18. Transverse heat transfer coefficient in the dual channel ITER TF CICCs. Part III: Direct method of assessment

    Science.gov (United States)

    Lewandowska, Monika; Malinowski, Leszek

    2016-01-01

    The data resulting from the thermal-hydraulic test of the ITER TF CICC are used to determine the flow partition and the overall effective heat transfer coefficient (hBC) between bundle and central channel in a direct way, i.e. by analysis of the heat transfer between both flow channels, based on the mass and energy balance equations and the readings of thermometers located inside the cable. In cases without a local heat source in the considered cable segment the obtained hBC values were consistent with those obtained in earlier studies by analysis of experimental data using indirect methods. It was also observed that the transverse heat transfer was strongly enhanced in a cable segment heated from outside. This phenomenon results from the mass transfer from the bundle region to the central channel. The experimental hBC data obtained for the case without a heat source in the considered segment were also compared with those calculated using various heat transfer correlations.

  19. The use of environmental tracers to determine focused recharge from a saline disposal basin and irrigation channels in a semiarid environment in Southeastern Australia

    Science.gov (United States)

    Robson, T. C.; Webb, J. A.

    2016-07-01

    Lake Tutchewop in southeastern Australia is a former ephemeral wetland that has been used as a saline disposal basin since 1968, forming part of the salinity management of the Murray River. The extent of saline focused recharge from Lake Tutchewop and fresh recharge from nearby unlined irrigation channels was determined using pore water and groundwater stable isotope and major ion chemistry, which were able to separate the influence of lake water, irrigation water and regional groundwater. In ∼45 years, saline water from Lake Tutchewop has infiltrated only up to 165 m from the lake edge in most directions, due to the underlying relatively impermeable clay-rich sediments, and a maximum of 700 m due to preferential groundwater flow along a sandy palaeochannel. The saline leakage has had limited, if any, impact on surrounding agricultural land use. Fresh water leakage from unlined irrigation channels extends up to 10 m deep, validating the current program to replace these channels with pipelines. This study demonstrates that focused recharge from different sources can be positively identified where the recharge waters have distinctive compositions, and that underlying clay-rich sediments restrict the extent of seepage. Therefore, management of focused recharge sources, particularly those that could decrease groundwater quality, requires a detailed knowledge of both the groundwater composition around the site and the underlying geology.

  20. Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1

    Science.gov (United States)

    Kuzmenkov, Alexey I.; Vassilevski, Alexander A.; Kudryashova, Kseniya S.; Nekrasova, Oksana V.; Peigneur, Steve; Tytgat, Jan; Feofanov, Alexey V.; Kirpichnikov, Mikhail P.; Grishin, Eugene V.

    2015-01-01

    The lesser Asian scorpion Mesobuthus eupeus (Buthidae) is one of the most widely spread and dispersed species of the Mesobuthus genus, and its venom is actively studied. Nevertheless, a considerable amount of active compounds is still under-investigated due to the high complexity of this venom. Here, we report a comprehensive analysis of putative potassium channel toxins (KTxs) from the cDNA library of M. eupeus venom glands, and we compare the deduced KTx structures with peptides purified from the venom. For the transcriptome analysis, we used conventional tools as well as a search for structural motifs characteristic of scorpion venom components in the form of regular expressions. We found 59 candidate KTxs distributed in 30 subfamilies and presenting the cysteine-stabilized α/β and inhibitor cystine knot types of fold. M. eupeus venom was then separated to individual components by multistage chromatography. A facile fluorescent system based on the expression of the KcsA-Kv1.1 hybrid channels in Escherichia coli and utilization of a labeled scorpion toxin was elaborated and applied to follow Kv1.1 pore binding activity during venom separation. As a result, eight high affinity Kv1.1 channel blockers were identified, including five novel peptides, which extend the panel of potential pharmacologically important Kv1 ligands. Activity of the new peptides against rat Kv1.1 channel was confirmed (IC50 in the range of 1–780 nm) by the two-electrode voltage clamp technique using a standard Xenopus oocyte system. Our integrated approach is of general utility and efficiency to mine natural venoms for KTxs. PMID:25792741

  1. Dual-channel optical sensing platform for detection of diminazene aceturate based on thioglycolic acid-wrapped cadmium telluride/cadmium sulfide quantum dots.

    Science.gov (United States)

    Hao, Chenxia; Zhou, Tao; Liu, Shaopu; Wang, Linlin; Huang, Bowen; Kuang, Nianxi; He, Youqiu

    2016-06-15

    A dual-channel optical sensing platform which combines the advantages of dual-wavelength overlapping resonance Rayleigh scattering (DWO-RRS) and fluorescence has been designed for the detection of diminazene aceturate (DA). It is based on the use of thioglycolic acid-wrapped CdTe/CdS quantum dots (Q-dots). In the absence of DA, the thioglycolic acid-wrapped CdTe/CdS Q-dots exhibit the high fluorescence spectrum and low RRS spectrum, so are selected to develop an easy-to-get system. In the presence of DA, the thioglycolic acid-wrapped CdTe/CdS Q-dots and DA form a complex through electrostatic interaction, which result in the RRS intensity getting enhanced significantly with new RRS peaks appearing at 317 and 397 nm; the fluorescence is powerfully quenched. Under optimum conditions, the scattering intensities of the two peaks are proportional to the concentration of DA in the range of 0.0061-3.0 μg mL(-1). The detection limits for the two single peaks are 4.1 ng mL(-1) and 3.3 ng mL(-1), while that of the DWO-RRS method is 1.8 ng mL(-1), indicating that the DWO-RRS method has high sensitivity. Besides, the fluorescence also exhibits good linear range from 0.0354 to 10.0 μg mL(-1) with a detection limit of 10.6 ng mL(-1). In addition, the system has been applied to the detection of DA in milk samples with satisfactory results.

  2. Nitrogen-Doped Graphene Quantum Dots@SiO2 Nanoparticles as Electrochemiluminescence and Fluorescence Signal Indicators for Magnetically Controlled Aptasensor with Dual Detection Channels.

    Science.gov (United States)

    Wang, Chengquan; Qian, Jing; Wang, Kun; Hua, Mengjuan; Liu, Qian; Hao, Nan; You, Tianyan; Huang, Xingyi

    2015-12-09

    We proposed a facile method to prepare the nitrogen-doped graphene quantum dots (NGQDs) doped silica (NGQDs@SiO2) nanoparticles (NPs). The NGQDs@SiO2 NPs were further explored as a versatile signal indicator for ochratoxin A (OTA) aptasensing by combination with electrochemiluminescence (ECL) and fluorescence (FL) detection. In this strategy, the core-shell Fe3O4@Au magnetic beads (MBs) acted as a nanocarrier to immobilize the thiolated aptamer specific for OTA, and the amino modified capture DNA (cDNA) was efficiently tagged with NGQDs@SiO2 NPs. The multifunctional aptasensor was thus fabricated by assembly of the NGQDs@SiO2 NPs onto the surface of Fe3O4@Au MBs through the high specific DNA hybridization between aptamer and cDNA. Upon OTA incubation, the aptamer linked with Fe3O4@Au MBs preferred to form an aptamer-OTA complex, which resulted in the partial release of the preloaded NGQDs@SiO2 NPs. The more OTA molecules in the detection system, the more NGQDs@SiO2 NPs were released into the bulk solution and the less preloaded NGQDs@SiO2 NPs were accumulated on the magnetic electrode surface. This provided a dual channel for OTA detection by combination with the enriched solid-state ECL and homogeneous FL detection. The FL assay exhibits a wide dynamic range and is more reproducible due to the homogeneous detection while the ECL assay possesses a lower detection limit and is preferable by using a cheaper instrument. One can obtain a preliminary screen from FL assay and a more accurate result from ECL assay. Integrating the virtues of dual analytical modality, this aptasensing strategy well-balanced the rapidity, sensitivity, and dynamic range, making it promising to other targets with aptamer sequences.

  3. 基于FPGA和LabVIEW的双通道示波器设计%Design of Dual-channel Oscilloscope Based on FPGA and LabVIEW

    Institute of Scientific and Technical Information of China (English)

    叶凯

    2012-01-01

    As the traditional oscilloscope is more expensive and it is difficult to preserve data for a long time,the design of dual -channel oscilloscope, which is based on LabVIEW and FPGA, is proposed. By way of signal attenuation and the AD9288 analog-digital conversion, the Cyeione series FPGA is adopted as its core to collect value of dual-channel inputting signal. Through the computer parallel port,the dynamic link library is invoked to the corresponding driver to achieve the communication between acquisition board and PC. Through the virtual oscilloscope based on LabVIEW, waveform curve can be collected by real-time program-controlled display, which reads the history of the acquired waveform. The system is user-defined on design parameters. A single - chip in the system, lest range from - 20 to + 20V, which runs stably, is used to fulfill the main logic function and the interface is use - friendly.%针对传统示波器价格昂贵且采集数据不能长久保存等问题,设计了一种基于FPGA和LabVIEW的双通道示波器.以Cyclone系列FPGA为核心,通过信号衰减及AD9288模数转换,采集双通道输入信号值;通过计算机并口,调用动态链接库对应驱动程序,实现采集板与PC机通信;通过LabvIEW设计的虚拟示波器实时程控显示采集的波形曲线和读取历史的采集波形.整个系统设计参数自定义,单芯片完成系统主要逻辑功能,测试范围为-20~+20 V,运行稳定性强,且方便用户操作使用.

  4. Dopant effects on 2-ethyl-1-hexanol: A dual-channel impedance spectroscopy and neutron scattering study

    Science.gov (United States)

    Singh, Lokendra P.; Raihane, Ahmed; Alba-Simionesco, Christiane; Richert, Ranko

    2015-01-01

    A two-channel impedance technique has been used to study the relaxation behavior of 2-ethyl-1-hexanol with polar and non-polar dopants at the few percent concentration level over a wide temperature and frequency range. The non-polar dopants shift both the Debye and the primary structural relaxation time in the same direction, to shorter times for 3-methylpentane and to longer times for squalane, consistent with the relative glass transition temperatures (Tg) of the components. By contrast, polar dopants such as water or methanol modify the α-process towards slower dynamics and increased amplitude, while the Debye process is accelerated and with a decreased amplitude. This effect of adding water to alcohol is explained by water promoting more compact structures with reduced Kirkwood correlation factors. This picture is consistent with a shift in the neutron scattering pre-peak to lower scattering vectors and with simulation work on alcohol-water systems.

  5. Dopant effects on 2-ethyl-1-hexanol: A dual-channel impedance spectroscopy and neutron scattering study

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Lokendra P.; Richert, Ranko, E-mail: ranko@asu.edu [Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604 (United States); Raihane, Ahmed; Alba-Simionesco, Christiane [Laboratoire Léon Brillouin, CNRS /CEA -UMR 12, DSM/IRAMIS/LLB CEA Saclay, 91191 Gif-sur-Yvette Cedex (France)

    2015-01-07

    A two-channel impedance technique has been used to study the relaxation behavior of 2-ethyl-1-hexanol with polar and non-polar dopants at the few percent concentration level over a wide temperature and frequency range. The non-polar dopants shift both the Debye and the primary structural relaxation time in the same direction, to shorter times for 3-methylpentane and to longer times for squalane, consistent with the relative glass transition temperatures (T{sub g}) of the components. By contrast, polar dopants such as water or methanol modify the α-process towards slower dynamics and increased amplitude, while the Debye process is accelerated and with a decreased amplitude. This effect of adding water to alcohol is explained by water promoting more compact structures with reduced Kirkwood correlation factors. This picture is consistent with a shift in the neutron scattering pre-peak to lower scattering vectors and with simulation work on alcohol-water systems.

  6. 双渠道供应链协调及价值扰动%COORDINATION AND VALUE DISRUPTION IN A DUAL-CHANNEL SUPPLY CHAIN

    Institute of Scientific and Technical Information of China (English)

    周伟刚; 高成修; 冯倩倩

    2011-01-01

    This article studies coordination and value-disruption problems in a dual-channel supply chain with demand model given by consumer behavior. We use Stackelberg game to model the system and use disruption management method to investigate the value-disruption problem. It is obtained that the equilibrium solution of the Stackelberg system without disruption and the optimal solution of the centralized system without disruption are robust to the value disruption tosome extent, which extends the results on 8upply chain disruption management.%本文研究了消费者选择行为给出的需求模型下双渠道供应链的协调与价值扰动问题.利用Stackelberg博弈对系统建模及其应急管理方法考虑价值扰动问题,获得了扰动前的Stackelberg博弈系统的均衡解和中心决策系统的最优解对价值扰动具有一定的橹棒性的结果,推广了供应链中的应急管理研究结果.

  7. A Radiation-Hard Dual Channel 4-bit Pipeline for a 12-bit 40 MS/s ADC Prototype with extended Dynamic Range for the ATLAS Liquid Argon Calorimeter Readout Electronics Upgrade at the CERN LHC

    CERN Document Server

    Kuppambatti, Jayanth; Andeen, Timothy; Kinget, Peter; Brooijmans, Gustaaf

    2013-01-01

    The design of a radiation-hard dual channel 12-bit 40 MS/s pipeline ADC with extended dynamic range is presented, for use in the readout electronics upgrade for the ATLAS Liquid Argon Calorimeters at the CERN Large Hadron Collider. The design consists of two pipeline A/D channels with four Multiplying Digital-to-Analog Converters with nominal 12-bit resolution each. The design, fabricated in the IBM 130 nm CMOS process, shows a performance of 68 dB SNDR at 18 MHz for a single channel at 40 MS/s while consuming 55 mW/channel from a 2.5 V supply, and exhibits no performance degradation after irradiation. Various gain selection algorithms to achieve the extended dynamic range are implemented and tested.

  8. UV/visible Fourier transform spectroscopy using an inductively-coupled plasma: dual-channel noise cancellation

    Science.gov (United States)

    Travis, J. C.; Winchester, M. R.; Salit, M. L.; Wythoff, B. J.; Scheeline, A.

    1993-04-01

    Although technological advances have extended the range of Fourier transform spectroscopy (FTS) into the UV/visible spectral domain, its application to spectroscopic and spectrometric problems has been hampered-relative to such applications in the infrared domain-by noise considerations. Although the technique retains high resolution, accurate wavelength registration, and simultaneous broad band coverage, the multiplex advantage present in the IR is severely compromised in the UV/visible due to the relative insignificance of detector noise. In particular, signal-carried noise distributes widely through the spectrum, degrading the dynamic range needed for many spectroscopic and analytical applications. This study demonstrates the use of complementary optical output channels in a commercial FTS to achieve up to ten-fold noise reductions for spectra acquired from an analytical inductively-coupled plasma with conventional pneumatic sample aspiration. The study also demonstrates the advisability of increasing the sampling rate of future instruments to exceed the maximum noise frequency characteristic of droplet evaporation effects.

  9. Integrated or dual vocational training focused on the operations of a nuclear power plant; La formacion profesional integrada y/o dual enfocada a la operativa de una central nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Roca, F.

    2014-10-01

    Dual vocational training is understood to be all the mixed employment and training actions and initiatives, the purpose of which in the vocational qualification of workers in a system alternating a job in a company with the training activity received in the framework of the vocational training system for employment of the educational system. The dual vocational training that results from this mixed strategy is provided via the following modality: Shared training between the training center and the company, which consists of coparticipation to varying degrees in the teaching and learning processes in the company and the training center. (Author)

  10. Supply chain coordination decision model of manufacture-led dual-channel supply%制造商主导型双渠道供应链协调决策模型

    Institute of Scientific and Technical Information of China (English)

    张学龙; 王军进

    2016-01-01

    以制造商主导型供应链为研究对象,分析双渠道供应链协调策略问题。引入双渠道价格敏感系数和竞争系数两个变量,分别建立双渠道供应链集中决策、分散决策和协调决策的3种模型。研究结果表明,不同合同策略协调后,零售商和供应链整体收益增加;经两部定价和批发价格合同协调,零售商需要支付固定费用给制造商才能够达到协调,而经Shapley值法分配合同协调,则双渠道供应链可直接达到协调效果。%The supply chain coordination decision problem of the manufacturer dual-channel is analyzed when the manufacturer-led supply chain is taken as the objective. With the introduction of two variables of the dual-channel price sensitive coefficient and the competition coefficient, three kinds of models of manufacturers concentrated decision, decentralized decision making and dual channel supply chain coordination strategy are established. Study results show that the profit of retailers and supply chain increase after the coordination of different contract strategies. By the coordination of two-part tariff and wholesale price contract, retailers can achieve coordination by paying fixed costs to manufacturers. And by coordinating the Shapley value assignment contract, the dual-channel supply chain can achieve coordination directly.

  11. Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels.

    Science.gov (United States)

    Vilela, Luciano R; Medeiros, Daniel C; de Oliveira, Antonio Carlos P; Moraes, Marcio F; Moreira, Fabricio A

    2014-10-01

    Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 channels, generally with an opposite outcome on neuronal modulation. Thus, we suggested that the dual FAAH and TRPV1 blockade with N-arachidonoyl-serotonin (AA-5-HT) would be efficacious in inhibiting pentylenetetrazole (PTZ)-induced seizures in mice. We also investigated the contribution of CB1 activation and TRPV1 blockade to the overt effect of AA-5-HT. In the first experiment, injection of AA-5-HT (0.3-3.0 mg/kg) delayed the onset and reduced the duration of PTZ (60 mg)-induced seizures in mice. These effects were reversed by pre-treatment with the CB1 antagonist, AM251 (1.0-3.0 mg/kg). Finally, we observed that administration of the selective TRPV1 antagonist, SB366791 (0.1-1 mg/kg), did not entirely mimic AA-5-HT effects. In conclusion, AA-5-HT alleviates seizures in mice, an effect inhibited by CB1 antagonism, but not completely mimicked by TRPV1 blockage, indicating that the overall effect of AA-5-HT seems to depend mainly on CB1 receptors. This may represent a new strategy for the development of drugs against seizures, epilepsies and related syndromes.

  12. Research strategies for pain in lumbar radiculopathy focusing on acid-sensing ion channels and their toxins.

    Science.gov (United States)

    Lin, Jiann-Her; Chiang, Yung-Hsiao; Chen, Chih-Cheng

    2015-01-01

    In lumbar radiculopathy, the dorsal root or dorsal root ganglia (DRG) are compressed or affected by herniated discs or degenerative spinal canal stenosis. The disease is multi-factorial and involves almost all types of pain, such as ischemic, inflammatory, mechanical, and neuropathic pain. Acid-sensing ion channels (ASICs) activated by extracellular acidosis play an important role in pain generation, and the effects of ASICs are widespread in lumbar radiculopathy. ASICs may be involved in the disc degeneration process, which results in disc herniation and, therefore, the compression of the dorsal roots or DRG. ASIC3 is involved in inflammatory pain and ischemic pain, and, likely, mechanical pain. ASIC1a and ASIC3 may have an important effect on control of the vascular tone of the radicular artery. In the central nervous system, ASIC1a modulates the central sensitization of the spinal dorsal horn. Thus, toxins targeting ASICs, because of their specificity, may help elucidate the roles of ASICs in lumbar radiculopathy and could be developed as novel analgesic agents.

  13. Value of probe-based confocal laser endomicroscopy (pCLE) and dual focus narrow-band imaging (dNBI) in diagnosing early squamous cell neoplasms in esophageal Lugol’s voiding lesions

    OpenAIRE

    Prueksapanich, Piyapan; Pittayanon, Rapat; Rerknimitr, Rungsun; Wisedopas, Naruemon; Kullavanijaya, Pinit

    2015-01-01

    Background and study aims: Lugol’s chromoendoscopy provides excellent sensitivity for the detection of early esophageal squamous cell neoplasms (ESCN), but its specificity is suboptimal. An endoscopy technique for real-time histology is required to decrease the number of unnecessary biopsies. This study aimed to compare the ESCN diagnostic capability of probed-based confocal laser endomicroscopy (pCLE) and dual focus narrow-band imaging (dNBI) in Lugol’s voiding lesions. Patients and methods:...

  14. Simulation on control of beam halo-chaos by power function in the hackle periodic-focusing channel

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The K-V beam through a hackle periodic-focusing magnetic field is studied using the particle-core model. The beam halo-chaos is found, and a power function controller is proposed based on mechanism of halo formation and strategy of controlling halo-chaos. Multiparticle simulation was performed to control the halo by using the power function control method. The results show that the halo-chaos and its regeneration can be eliminated effectively. We also find that the radial particle density evolvement is of uniformity at the beam's centre as long as appropriate paramours are chosen.

  15. 电子商务环境下双渠道供应链协调的价格折扣模型%Price discount model for coordination of dual-channel supply chain under e-commerce

    Institute of Scientific and Technical Information of China (English)

    徐广业; 但斌

    2012-01-01

    针对电子商务环境下传统零售与电子直销并存的双渠道模式,在制造商为主方的Stackelberg对策博弈下,建立了能够协调双渠道供应链的价格折扣模型.论证了在这种价格折扣协调机制下,虽然能够增加双渠道供应链和零售商的利润,但是制造商将遭受到损失.为此,设计了一种转移支付机制使制造商和零售商能够达到双赢的局面.最后,通过算例分析检验了所设计的协调机制的有效性.%For the dual-channel mode of the coexistence of traditional retail channel and electronic direct channel under e-commerce, this paper establishes a price discount model to coordinate dual-channel supply chain when the manufacturer is a leader in Stackelberg game. Under the price discount coordination mechanism, it is proved that the profits of the dual-channel supply chain and retailer are increased, but the profit of the manufacturer is reduced. With regards to this, a transfer payment mechanism is designed to enable the manufacturer and retailer to achieve a win-win situation. Finally, a numerical example is used to verify the effectiveness of the designed coordination mechanisms.

  16. Control of Beam Halo-Chaos by Fraction Power-Law Function in Hackle Periodic-Focusing Channel

    Institute of Scientific and Technical Information of China (English)

    YU Hai-Jun; BAI Long; WENG Jia-Qiang; LUO Xiao-Shu; FANG Jin-Qing

    2008-01-01

    The Kapehinsky-Vladimirsky (K-V) beam through a hackle periodic-focusing magnetic field is studied using the particle-core model. The beam halo-chaos is found, and an idea of fraction power-law function controller is proposed based on the mechanism of halo formation and the strategy of controlling halo-chaos. The method is applied to the multi-particle simulation to control the halo. The numerical results show that the halo-chaos and its regeneration can be eliminated effectively by using the fraction power-law function control method. At the same time, the radial particle density is uniform at the beam's center as long as the control method and appropriate parameter are chosen.

  17. Optical Imaging with a Cathepsin B Activated Probe for the Enhanced Detection of Esophageal Adenocarcinoma by Dual Channel Fluorescent Upper GI Endoscopy

    Directory of Open Access Journals (Sweden)

    Peiman Habibollahi, Jose-Luiz Figueiredo, Pedram Heidari, Austin M Dulak, Yu Imamura, Adam J. Bass, Shuji Ogino, Andrew T Chan, Umar Mahmood

    2012-01-01

    Full Text Available Despite significant advances in diagnosis and treatment, the prognosis of esophageal adenocarcinoma remains poor highlighting the importance of early detection. Although white light (WL upper endoscopy can be used for screening of the esophagus, it has limited sensitivity for early stage disease. Thus, development of new imaging technology to improve the diagnostic capabilities of upper GI endoscopy for early detection of esophageal adenocarcinoma is an important unmet need. The goal of this study was to develop a method for the detection of malignant lesions in the esophagus using WL upper endoscopy combined with near infrared (NIR imaging with a protease activatable probe (Prosense750 selective for cathepsin B (CTSB. An orthotopic murine model for distal esophageal adenocarcinoma was generated through the implantation of OE-33 and OE-19 human esophageal adenocarcinoma lines in immunocompromised mice. The mice were imaged simultaneously for WL and NIR signal using a custom-built dual channel upper GI endoscope. The presence of tumor was confirmed by histology and target to background ratios (TBR were compared for both WL and NIR imaging. NIR imaging with ProSense750 significantly improved upon the TBRs of esophageal tumor foci, with a TBR of 3.64±0.14 and 4.50±0.11 for the OE-33 and OE-19 tumors respectively, compared to 0.88±0.04 and 0.81±0.02 TBR for WL imaging. The combination of protease probes with novel imaging devices has the potential to improve esophageal tumor detection by fluorescently highlighting neoplastic regions.

  18. Application of dual time phases imaging of 18F-FDG PET/CT to diagnosis of pulmonary sarcoidosis focus%18F-FDG双时相显影在肺结节病灶中的应用

    Institute of Scientific and Technical Information of China (English)

    周克; 吴平; 陈治明; 陈钰

    2011-01-01

    目的 探讨18F-FDG双时相显影在肺结节性病灶诊断与鉴别诊断的临床应用价值.方法 回顾性分析43例18F-FDG双时相显影且经病理证实的肺结节性病例.其中男性31例,女性12例,年龄38~84岁.使用18F-FDG行全身或肺部PET/CT及双时相病灶扫描,依据PET图像、CT图像、PET/CT融合图像进行综合性分析.结果 43例肺结节性病灶的病例中,双时相显影诊断肺癌26例,病理证实23例;诊断可疑肺癌8例,病理证实5例;诊断良性病变9例,病理证实8例.结论 对于肺结节性病灶,应用18F-FDG双时相显影可提高诊断的准确性.%Objective To investigate the clinical application values of dual time phases imaging of 18 F - FDG PET/CT to diagnosis of the diagnosis and differential diagnosis of pulmonary sarcoidosis focus. Methods A retrospective analysis was made in 43 patients( 31 men, 12 women and aged from 38 to 84 years )with detected by dual time phases imaging of 18F - FDG PET/CT and confirmed by pathological examination. They received the whole body or lung PET/CT and dual time phase focal scanning, and a comprehensive analysis was made according to the PET,CT images and PET/CT fusion images. Results Among the 43 subjects,26 ones were diagnosed as lung cancer by the dual time phase imaging and 24 ones were verified by pathological examination; 8 ones were diagnosed as suspicious lung cancer by the dual time phase imaging and 5 ones were verified by pathological examination;9 ones were diagnosed as benign lesion and 8 ones were verified by pathological examination. Conclusion The application of dual time phase imaging of 18F - FDG PET/CT can improve the accuracy of the diagnosis of pulmonary sarcoidosis focus.

  19. Competing and Coordination Strategies for the Dual Channel under Stochastic Demand and Cooperative Promotion%随机需求和联合促销下双渠道供应链的竞争与协调

    Institute of Scientific and Technical Information of China (English)

    禹爱民; 刘丽文

    2012-01-01

    An increasing number of manufacturers are adopting the dual sales channel structure: selling their products to customers via both online and physical channels. Although many companies, including HP, IBM, are using the dual channel to distribute products successfully, some of these manufacturers are facing problems. One major problem is about how a manufacturer can motivate its retailers to expand the market and coordinate these two channels. To motivate their retailers, an increased number of manufactures cooperate with retailers to make promotion. For instance, a manufacture shares promotion fees with its retailers or the manufacturer sends its employees to help retailer conduct promotional activities.The paper studies the pricing competing and channel coordination strategies in the dual channel supply chain where manufacturer and retailer face the stochastic demand and they need to cooperate to make promotion. The research result shows that the Nash equilibrium of price exists and the optimal price of the online channel will decrease the effort of a retailer. The promotional effort of a retailer will increase in the ratio of cost shared by its manufacturer. When the ratio is low, a retailer's effort will increase slowly in the ratio. When the ratio is high, a retailer's effort will increases rapidly in the ratio. Furthermore, this paper proves that the buy-back contract will benefit each other. However, the contract cannot coordinate the whole supply chain.%针对制造商同时拥有零售渠道和网上直销渠道的双渠道供应链系统,在随机需求和联合促销情况下,对制造商和零售商之间的价格竞争和协调问题进行研究.研究表明价格的纳什均衡解存在,网上渠道的最优价格随零售商促销努力程度的增大而降低.当制造商分担促销成本的比例上升时,零售商促销的努力程度会增加.当比例值较低时,零售商的努力程度变化不大;当比例值超过一定数值时,零售商

  20. Dual Income Taxes

    DEFF Research Database (Denmark)

    Sørensen, Peter Birch

    This paper discusses the principles and practices of dual income taxation in the Nordic countries. The first part of the paper explains the rationale and the historical background for the introduction of the dual income tax and describes the current Nordic tax practices. The second part...... of the paper focuses on the problems of taxing income from small businesses and the issue of corporate-personal tax integration under the dual income tax, considering alternative ways of dealing with these challenges. In the third and final part of the paper, I briefly discuss whether introducing a dual income...... tax could be relevant for New Zealand....

  1. Dual Income Taxes

    DEFF Research Database (Denmark)

    Sørensen, Peter Birch

    This paper discusses the principles and practices of dual income taxation in the Nordic countries. The first part of the paper explains the rationale and the historical background for the introduction of the dual income tax and describes the current Nordic tax practices. The second part...... of the paper focuses on the problems of taxing income from small businesses and the issue of corporate-personal tax integration under the dual income tax, considering alternative ways of dealing with these challenges. In the third and final part of the paper, I briefly discuss whether introducing a dual income...

  2. A Compensation Strategy for Coordinating Dual-channel Supply Chains in E-commerce%电子商务环境下双渠道供应链协调的补偿策略研究

    Institute of Scientific and Technical Information of China (English)

    但斌; 徐广业; 张旭梅

    2012-01-01

    With the rapid development of E-Commerce, using Internet as a sales channel has received much attention from both the academy and industry. An increased number of companies have used Internet sales channels to reduce costs and expand market. Because of the existence of physical retail stores, Internet sales channels can inevitably lead to channel competition and conflicts, which are both an opportunity and a challenge for companies. The goal of this dissertation is to understand the operating mechanism of dual-channel supply chains and improve their operating efficiency. In this paper the interaction between supply chain members is analyzed through a game model, and the source of the ineffectiveness in dual-channel supply chains is explored and measured. In the end, an optimization and coordination mechanism is proposed.We first consider a centralized system in which all decisions are centralized to maximize performance for the entire supply chain. For instance, a manufacturer is vertically integrated with its retailers in the retailing channel. The vertical integration enables the manufacturer to control both retail price and direct sale price. The centralized system solution serves as a benchmark for the decentralized setting. We then consider a decentralized supply chain using the Stackelberg game. In the decentralized setting, both manufacturer and retailer make their own decisions to maximize individual profits. It is assumed that information on each player's demand function, cost structure, and decision rules is a common knowledge for all the parties concerned. The decision process follows the sequence: (1) a manufacturer as the Stackelberg leader determines the wholesale price and the direct sale price, and (2) a retailer as the follower sets his own optimal retail price based on the manufacturer's decisions. Furthermore, to coordinate the decentralized dual-channel supply chain we propose a new contract as the compensation mechanism to coordinate dual-channel

  3. Study of Demand Information Sharing in Dual-channel Supply Chain%双渠道供应链合作模式下需求信息共享研究

    Institute of Scientific and Technical Information of China (English)

    李舒婷

    2016-01-01

    根据现有的双渠道供应链相关研究文献,探讨了双渠道供应链需求信息共享问题,阐述了需求信息共享对于双渠道供应链合作的作用,指出了在双渠道供应链合作中进行信息共享的方法与策略,从而有效地协调双渠道供应链中的冲突与竞争问题,促使双渠道供应链整体及各个成员获得更多收益。%According to the existing literature of supply chain,demand information sharing in dual-channel supply chain are discussed. It is concluded that demand information sharing affects the cooperation of dual-channel supply chain. Then it puts forward the method and strategy of information sharing in order to resolve the conflict and competition problems in du-al-channel supply chain and greatly improve the profits of the whole chain.

  4. A retrospective analysis focusing on a group of patients with dual diagnosis treated by both mental health and substance use services

    Directory of Open Access Journals (Sweden)

    Di Lorenzo R

    2014-08-01

    Full Text Available Rosaria Di Lorenzo,1 Agnese Galliani,2 Alessia Guicciardi,3 Giulia Landi,3 Paola Ferri2 1Mental Health Department, Azienda USL di Modena, Modena, Italy; 2School of Nursing, University of Modena and Reggio Emilia, Modena, Italy; 3Department of Psychiatry, University of Modena and Reggio Emilia, Modena, Italy Objective: To highlight which demographic, familial, premorbid, clinical, therapeutic, ­rehabilitative, and assistance factors were related to dual diagnosis, which, in psychiatry, means the co-occurrence of both mental disorder and substance use in the same patient.Methods: Our sample (N=145 was chosen from all outpatients with a dual diagnosis treated from January 1, 2012 to July 31, 2012 by both the Mental Health Service and the Substance Use Service of Modena and Castelfranco Emilia, Italy. Patients who dropped out during the study period were excluded. Demographic data and variables related to familial and premorbid history, clinical course, rehabilitative programs, social support and nursing care, and outcome complications were collected. The patients’ clinical and functioning conditions during the study period were evaluated.Results: Our patients were mostly men suffering from a cluster B personality disorder. Substance use was significantly more likely to precede psychiatric disease (P<0.001, and 60% of the sample presented a positive familial history for psychiatric or addiction disease or premorbid traumatic factors. The onset age of substance use was related to the period of psychiatric treatment follow-up (P<0.001 and the time spent in rehabilitative facilities (P<0.05, which, in turn, was correlated with personality disorder diagnosis (P<0.05. Complications, which presented in 67% of patients, were related to the high number of psychiatric hospitalizations (P<0.05 and professionals involved in each patient’s treatment (P<0.05. Males more frequently presented familial, health, and social complications, whereas females more

  5. Visible-light-driven TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO heterostructure photocatalyst with dual-channel for photo-generated charges separation

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Bingqing; Ma, Ni; Wang, Yaping; Qiu, Yiwei [Center for Optoelectronics Materials and Devices, Department of Physics, Zhejiang Sci-Tech University, Hangzhou 310018 (China); Hu, Haihua [Zhejiang University City College, Hangzhou 310015 (China); Zhao, Jiahuan; Liang, Dayu; Xu, Sheng; Li, Xiaoyun; Zhu, Zhiyan [Center for Optoelectronics Materials and Devices, Department of Physics, Zhejiang Sci-Tech University, Hangzhou 310018 (China); Cui, Can, E-mail: cancui@zstu.edu.cn [Center for Optoelectronics Materials and Devices, Department of Physics, Zhejiang Sci-Tech University, Hangzhou 310018 (China)

    2015-05-05

    Highlights: • TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO was synthesized with a facile two-step method. • TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO exhibit superior photocatalytic activity and stability. • TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO has dual-channel for photo-generated charges separation. • TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO composite reduces the consumption of Ag. - Abstract: A novel triple-component TiO{sub 2}/Ag{sub 3}PO{sub 4}/graphene oxide (TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO) photocatalyst with dual channels for photo-generated charges separation has been synthesized to improve the photocatalytic activity and stability of Ag{sub 3}PO{sub 4} under visible light. The synthesis involved in-situ growth of Ag{sub 3}PO{sub 4} nanoparticles on GO sheets to form Ag{sub 3}PO{sub 4}/GO, and then deposited TiO{sub 2} nanocrystals on the surface of Ag{sub 3}PO{sub 4} by hydrolysis of Ti(SO{sub 4}){sub 2} at low-temperature hydrothermal condition. The TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO exhibited superior photocatalytic activity and stability to bare Ag{sub 3}PO{sub 4}, TiO{sub 2}/Ag{sub 3}PO{sub 4} and Ag{sub 3}PO{sub 4}/GO in degradation of Rhodamine B and phenol solutions under visible light. It is suggested that the photo-generated electrons in the conduction band of Ag{sub 3}PO{sub 4} can be quickly transferred to GO, while the holes in the valence band of Ag{sub 3}PO{sub 4} can be transferred to the valence band of TiO{sub 2}. The dual transfer channels at the interfaces of TiO{sub 2}/Ag{sub 3}PO{sub 4}/GO result in effective charges separation, leading to enhanced photocatalytic activity and stability. Furthermore, the content of noble metal Ag significantly reduces from 77 wt% in bare Ag{sub 3}PO{sub 4} to 55 wt% in the nanocomposite. The concept of establishing dual channels for charges separation in a triple-component heterostructure provides a promising way to develop photocatalysts with high efficiency.

  6. 虚实通路双栖族消费者认知风险、生活型态与产品类型对通路选择之影响%The Impact of Consumer Perceived Risk, Life Styles, and Product Types on Channel Selection of Dual-Channel Shoppers

    Institute of Scientific and Technical Information of China (English)

    吴文杰; 吕易亭

    2014-01-01

    Researches in the past of dual-channel shoppers are more on employees and students, but less on other categories of shoppers with facing different types of products. The purpose of this study is to analyze the main factors and comparison of shopping behaviors under different lifestyles on choices of dual channels. Through a survey with questionnaires and analysis, this study shows that:Even dual-channel shoppers tend to prefer physical channels under higher perceived risk. For different types of product, consumers’ awareness of the perceived risk on the channel selection is different. Besides, shoppers of different lifestyles may also consider different issues while purchasing various types of products. This research may provide more understanding on dual-channel shoppers for academic, and practically, also may help companies precisely find the need of customers in different segments.%本研究主要目的在分析不同生活型态对双栖族的购买行为,并比较双栖通路间购买行为的差异,以及探讨哪些主要因素及其对消费者通路选择决策的影响。结果显示:即便是双栖族消费者,其认知风险愈高倾向选择实体通路,而不同产品类型上,消费者认知风险对通路选择的影响有差异;此外,不同生活型态消费者,针对不同类型产品,在考虑通路选择时也有差异。本文除可以补足双栖族群这方面的研究,企业可进一步地了解消费者选择不同通路时,针对不同产品类型的价值考虑,亦能更精确的找出顾客需求进行区隔。

  7. Horizontal Cooperation Strategy of After-sales Service in Dual-channel Supply Chain%双渠道供应链中售后服务横向合作策略

    Institute of Scientific and Technical Information of China (English)

    陈远高; 郭燕翔

    2013-01-01

    Considering the outsourcing after-sales service provided to online shoppers by a traditional retailer,the horizontal cooperation service strategy and coordination of dual-channel supply chain with internet direct channel and traditional retailer channel were studied.The demand model of dual channel supply chain under horizontal service cooperation was developed,and the optimal decisions of supply chain members were compared with each other.The two propositions of optimal pricing and service provision were presented for the supply chain effective cooperation.Finally,the numerical experiment was done to discuss the impact of related parameters on the decision variables of supply chain members.The results show that the service cooperation leads to the optimal allocation of service resource in supply chain system and promotes the profit of dual-channel partners to achieve win-win outcome.%针对传统零售商向网络直销渠道消费者提供售后服务时,双渠道供应链系统的横向合作策略与协调问题,建立了存在售后服务横向合作的双渠道供应链需求模型,分析了Stackelberg博弈中供应链成员的最优策略,并研究了渠道的最优定价和服务水平的相关命题,最后进行了算例分析,探讨了渠道竞争程度、服务敏感程度等参数对供应链决策变量的影响.结果表明,传统渠道商与网络渠道商之间通过售后服务外包实现横向服务合作,可以实现供应链系统的优化,在大多数情况下能够有效提升双渠道供应链成员的利润水平从而实现双赢.

  8. Pricing and cooperative advertising decision models in dual-channel supply chain%双渠道供应链中定价与合作广告决策模型

    Institute of Scientific and Technical Information of China (English)

    黄松; 杨超; 张曦

    2011-01-01

    To study the influence of cooperative advertising strategy on channel supply chain pricing decision,the two-echelon supply chain system composed of one manufacturer and one retailer was considered.The manufacturer sold the products to end customers both through the direct channel and the traditional retail channel.The demands in two channels were influenced by both prices and advertising investment level.The pricing strategy and cooperative advertising decisions in a centralized dual-channel supply chain and in a decentralized dual-channel supply chain based on Stackelberg game were analyzed.The two-stage optimization technique was utilized to obtain the optimal pricing decisions and advertising investment level.The numerical studies revealed that the manufacturers and the retailers pricing decisions were largely influenced by advertising investment.Customers preferences for the retail channel and the cooperative advertising ratio were closely related to both the optimal pricing decisions and the optimal advertising investment.%为研究合作广告决策对渠道供应链定价决策的影响,考虑由单一制造商和单一零售商组成的两级供应链系统,制造商可以通过直销渠道将产品销售给顾客,也可以通过传统的零售渠道将产品销售给顾客,两种渠道的需求都受到价格和广告投入水平的影响。分析了集中式双渠道供应链的定价与合作广告决策,以及基于Stack-elberg博弈时分散式双渠道供应链的定价与合作广告决策。利用两阶段优化技术得到了供应链的最优定价决策和广告投入水平。数值算例表明,广告投入对于制造商和零售商的定价决策有重要影响,制造商和零售商的最优定价决策和最优广告投入水平与顾客对零售渠道的偏好程度以及合作广告的分担比例密切相关。

  9. Coordination mechanism of dual-channel closed-loop supply chain based on third-party collection%基于第三方回收的双渠道闭环供应链协调机制

    Institute of Scientific and Technical Information of China (English)

    许茂增; 唐飞

    2013-01-01

    针对双渠道闭环供应链的协调问题,基于博弈理论构建了制造商进行网上直销、零售商进行传统零售、第三方负责废旧产品回收的双渠道闭环供应链决策模型.分析和比较了集中决策与分散决策对供应链成员最优定价策略和利润的影响,发现分散决策会导致整个双渠道闭环供应链的效率损失.为弥补这种效率损失,以集中决策的最优结果为基准,设计了一个利润共享—费用分担契约来实现双渠道闭环供应链的协调.算例分析表明,所设计的利润共享一费用分担契约能够有效协调双渠道闭环供应链.%Aiming at the coordination problem of dual-channel closed-loop supply chain,a dual-channd closed-loop supply chain decision model with a manufacturer,a retailer and a third-party was established based on game theory.The influence of centralized decision-making and decentralized decision-making on optimal pricing strategy and optimal supply chain members' profit was analyzed,and the efficeney loss of dual-channel closed-loop supply chain was leaded by decentralized decision-making.To make up for such efficiency loss,a profit and expense sharing contract was designed to realize the coordination of dual-channel closed-loop supply chain based on the optimal result of centralized decision-making.The effectiveness of the profit and expense sharing contract was verified through a numerical example.

  10. Design of a High-precision Dual-channel Electric Energy Metering Device%高精度双通道电能计量装置的设计

    Institute of Scientific and Technical Information of China (English)

    李楠

    2014-01-01

    介绍了一种电能计量装置以AVR单片机作为主控芯片,采用ATT7022B专用计量芯片检测基波、谐波和全波的各项电能参数,辅以存储、显示、通信等外围电路,体积小、功能全,并采用双通道设计减小误差,提高了计量精度。%This paper introduces a high precision dual channel electric energy metering device with AVR microcontroller as the central controlling chip,using ATT7022B to measure the electric energy parameters of fundamental wave,harmonic wave and full wave. The de-vice integrates the functions of storage,display and communication,with a small size and full functions,and uses dual channel to mini-mize measurement errors and improves system accuracy.

  11. 一种双通道微波密度湿度检测仪的研制%A Development for Dual-Channel Microwave Density and Humidity Detector

    Institute of Scientific and Technical Information of China (English)

    林伟; 杨健荣

    2015-01-01

    Dual-channel density and humidity detector as ultra-high speed rol ing machines cigarette weight control system sensor,used for density and humidity of cigarette online detection is an important part of the sys-tem.In this paper,a design scheme of Dual-channel density and humidity detector is presented,first introduces the measuring principle of detector,and then introduces the whole detector architecture,final y the design and implementation of the detector is described in detail.%双通道微波密度湿度检测仪作为高速、超高速机型上烟支重量控制系统的传感器,用于烟草卷接机烟条密度、湿度的在线检测,是该系统的一个重要组成部分。该文提出了一种双通道微波密度湿度检测仪的研制的设计方案,先介绍了该检测仪测量原理,然后介绍了整机构成,最后详细阐述了整机设计与实现过程。

  12. Pricing Strategies of a Dual-Channel Supply Chain with Participants of Fairness Preference%具有公平偏好参与者的双渠道供应链定价策略研究

    Institute of Scientific and Technical Information of China (English)

    成克河; 王磊; 王世伟

    2013-01-01

    近几年来,网络直销和传统零售两种模式愈演愈烈。其实,在供应链为背景下,供应链上每个成员的公平偏好因素是不可忽视的。通过建立公平偏好效用涵数及数值仿真模型,分析供应链成员定价策略,其结果表明,最优直销价格不受公平偏好因素的影响,最优批发价格、最优零售价格、供应链成员的效用和系统的总效用受公平偏好因素的影响,受影响的程度由公平偏好度的大小决定。但实际上在供应链的运作过程中参与者的公平偏好信息一般是不会共享的。%In recent years, the operation of a dual-channel pattern of online direct sales and traditional retail has been a research focus. In fact, the fairness preference of every participant is significant in a supply chain. Utility functions of fairness preference and a numerical simulation model are set up to analyze the pricing strategies of participants in the supply chain. It is found that the optimal direct selling price is not affected by the fairness preference;the optimal whole selling price, optimal retailing price, effectiveness of the supply chain participants and the total utility of the system are influenced by the fairness preference with various impact degrees determined by different fairness preference degrees. However, participants in the supply chain do not share the information of their fairness preference in practice.

  13. Characterising coarse PBA dynamics in real-time above and below a tropical rainforest canopy using a dual channel UV fluorescence aerosol spectrometer.

    Science.gov (United States)

    Gabey, A.; Gallagher, M. W.; Burgess, R.; Coe, H.; McFiggans, G.,; Kaye, P. H.; Stanley, W. R.; Davies, F.; Foot, V. E.

    2009-04-01

    single-particle dual channel UV fluorescence spectrometer (Kaye et al., 2008) capable of detecting PBA by inducing fluorescence in two so-called biofluorophores - one present during metabolism and the other an amino acid - in the particle size range 1 m 2 m. In qualitative agreement with measurements of culturable airborne material in a tropical forest's understory (Gilbert, 2005) a diurnal cycle of PBA number concentration is present, reaching a maximum of ~4000 l-1 at local midnight and falling to ~100 l-1 around midday. The role of the planetary boundary layer's collapse and re-establishment in dictating this variation in is also investigated using LIDAR data. Transient PBA concentration spikes lasting several minutes are superposed on the smooth underlying diurnal variation and occur at similar times each day. Nucleopore filter samples were also taken in-situ and analysed under an Environmental scanning electron microscope (ESEM) in Manchester. The images obtained showed the PBA fraction to be dominated by fungal spores of diameter 2-5 m, from various species including ABM. Since such species tend to release spores in bursts at regular times this appears to account for the PBA concentration spikes.

  14. "酒店+OTA"双渠道供应链的销售策略及协调机制研究%Research on Marketing Policy and Coordination Mechanism of"Hotel+OTA"Dual-Channel Supply Chain

    Institute of Scientific and Technical Information of China (English)

    浦徐进; 杜晓东

    2016-01-01

    在"酒店+OTA"双渠道供应链背景下,构建酒店和 OTA 网站之间的 Stacklberg 博弈模型,考察酒店的网站销售价格和网站促销努力的变化逻辑,并设计一个酒店分担 OTA网站促销努力成本的协调机制来改善供应链运作效率.研究发现:酒店房间数、通过前台订房的旅客数量均值等因素将影响酒店的销售策略;相比于集中决策下的情况,分散决策下 OTA网站的促销努力水平和供应链整体利润将降低;合理设计的促销成本分担机制可以实现酒店和 OTA网站双方利润水平的Pareto改进.研究结论将为促进"酒店+OTA"双渠道供应链的良性运作提供决策借鉴.%Considering the "Hotel+OTA"dual-channel supply chain,this paper builds a Stacklberg game model between the hotel and the OTA website,and analyzes the change logic of hotel's sales prices and the OTA website's promotion efforts.A new contract that the hotel shares a part of the OTA website's promotional effort costs is designed to coordinate the whole dual-channel supply chain.This paper also designs channel coordination with which hotel shares the OTA website's promotion effort cost to improve the operating efficiency of supply chain.Results show that:(1)Some factors,such as the number of hotel rooms and the average number of passengers who book at the front desk,will affect the hotel's marketing policy.(2)Compared with the centralized setting,the level of OTA website's promotion effort and the profit of the supply chain will decrease in the decentralized setting.(3 )The promotional cost-sharing mechanism can lead to a Pareto improvement of the profit level of both the hotel and the OTA website. These conclusions can provide decision-making reference for promoting the dual-channel supply chain for a hotel and a website to operate efficiently.

  15. Multi-period supply chain network equilibrium problem based on dual-channel and dual-objective remanufacturing%基于再制造的双渠道双目标多期闭环供应链网络均衡问题

    Institute of Scientific and Technical Information of China (English)

    吴克晴; 赖青芳

    2016-01-01

    研究了网上直销渠道和传统实体交易渠道的双渠道回收模式下的多期闭环供应链网络均衡问题,假设制造商/回收中心和零售商均追求利润最大化和风险最小化双重目标,利用变分不等式理论刻画了不同决策者的优化行为,建立了基于再制造的双渠道双目标多期闭环供应链网络均衡模型。结合算例分析了单/双渠道回收模式下闭环供应链网络均衡解的情形,并讨论了旧产品的再制造转化率对均衡解的影响。算例结果表明:采用双渠道方式回收有利于提高制造商和供应链整体的经济效益,在追求风险最小化目标的同时,应在一定范围内适当提高旧产品的再制造转化率,这样才能实现供应链整体及链上各成员追求利润最大化和风险最小化双重目标的共赢。%The multi-period closed-loop supply chain network equilibrium problem is studied under the dual channel recycling mode of the online direct selling channel and the traditional entity trading channel, assuming that the manufacturer / recycling centers and retailers are the pursuit of profit maximization and risk minimization in virtue of variational inequality theory. The optimal behaviors of different decision makers are analyzed, and a multi-period supply chain network equilibrium model is established based on dual-channel and dual-objective remanufacturing. Finally, numerical examples are given to analyze the network equilibrium result of single/dual channel recycling model and to discuss the influence of the conversion rate of the old product on the equilibrium solution. The obtained results show that the recycling way of the dual channel is helpful to improve the economic benefit of manufacturers and the whole supply chain, and to pursue risk minimization at the same time. The conversion rate of the old product should be increased in a certain range, so as to realize a win-win goal that the whole supply chain

  16. A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats

    DEFF Research Database (Denmark)

    Kirkedal, Christian; Wegener, Gregers; Moreira, Fabricio;

    2016-01-01

    -like effect via CB1-R stimulation and depressive-like effect via TRPV1 activation. This is supposed to explain the bell-shaped dose-response curve for anandamide in preclinical models. METHODS: We investigated this assumption by administering the dual inhibitor of AEA hydrolysis and TRPV1 activation N...

  17. Dual regulation of the native ClC-K2 chloride channel in the distal nephron by voltage and pH.

    Science.gov (United States)

    Pinelli, Laurent; Nissant, Antoine; Edwards, Aurélie; Lourdel, Stéphane; Teulon, Jacques; Paulais, Marc

    2016-09-01

    ClC-K2, a member of the ClC family of Cl(-) channels and transporters, forms the major basolateral Cl(-) conductance in distal nephron epithelial cells and therefore plays a central role in renal Cl(-) absorption. However, its regulation remains largely unknown because of the fact that recombinant ClC-K2 has not yet been studied at the single-channel level. In the present study, we investigate the effects of voltage, pH, Cl(-), and Ca(2+) on native ClC-K2 in the basolateral membrane of intercalated cells from the mouse connecting tubule. The ∼10-pS channel shows a steep voltage dependence such that channel activity increases with membrane depolarization. Intracellular pH (pHi) and extracellular pH (pHo) differentially modulate the voltage dependence curve: alkaline pHi flattens the curve by causing an increase in activity at negative voltages, whereas alkaline pHo shifts the curve toward negative voltages. In addition, pHi, pHo, and extracellular Ca(2+) strongly increase activity, mainly because of an increase in the number of active channels with a comparatively minor effect on channel open probability. Furthermore, voltage alters both the number of active channels and their open probability, whereas intracellular Cl(-) has little influence. We propose that changes in the number of active channels correspond to them entering or leaving an inactivated state, whereas modulation of open probability corresponds to common gating by these channels. We suggest that pH, through the combined effects of pHi and pHo on ClC-K2, might be a key regulator of NaCl absorption and Cl(-)/HCO3 (-) exchange in type B intercalated cells.

  18. Dual-Channel Strategies for Retailers with Price and Service Competition%基于价格和服务竞争的零售商双渠道策略

    Institute of Scientific and Technical Information of China (English)

    张盼; 熊中楷; 郭年

    2012-01-01

    为了研究存在价格和服务竞争时零售商的双渠道策略,在双寡头市场中运用Hotelling模型求得了零售商价格和服务水平的均衡解,分析了网络渠道的开通对零售商定价、服务水平及其利润的影响,讨论了消费者信息搭便车时零售商是否开通网络渠道.研究表明:当零售商间差异较小时,网络渠道的开通会使零售商提供较多的服务,获得较少的利润;当考虑信息搭便车时,都不开通网络渠道、只有一个开通网络渠道、两个都开通网络渠道都可能是均衡的渠道结构,其中零售商都开通网络渠道是一个囚徒困境.%The issue of retailers' dual-channel strategies with price and service competition is discussed. In a duopoly market environment, a Hotelling model is presented for this problem. Then, the equilibrium so-lutions of prices and service level are obtained. Based on the solutions, impact of additional Internet chan-nel on prices, service level, and profits is examined. Furthermore, in considering the behavior of informa-tion-based free-riding, it analyzes whether retailers can open direct channel. Result shows that when the differentiation among the competing retailers is not too large, an online channel can result in increase of service level and decrease of profit. Furthermore, in considering information-based free-riding behavior, any of the three channel strategies, i. e. no Internet channel, asymmetric Internet channel, and symmetric Internet channel, is the possible equilibria. Also, multichannel retailing for all retailers is a prisoner' s di-lemma.

  19. A Decision Model in a Dual-channel Supply Chain with Market Segmentation%基于市场细分的双渠道供应链决策模型

    Institute of Scientific and Technical Information of China (English)

    陈军; 赖信; 何圆

    2013-01-01

    An idea that the retailer should open secondary market at the end of the primary market life cycle is proposed .The pricing decision models in a dual-channel supply chain are developed on the assumption that mar-ket information is prefect , then the retailer ’ s and the manufacturer ’ s optimal prices are obtained for the case that the retailer opens secondary market with utility function .The conclusion suggests that the retailer doesn ’ t open secondary market if only the direct channel exits in the primary market , and it may contributes to achieving Pare-to improvement of the profits for the dual-channel members by the introduction of the secondary market if demands exit for the two channels under decentralized decision model .The system profit increases only if de-mands exit for the two channels and the two markets , and the parameter of acceptance of the secondary market exceeds a critical value under centralized decision model .So, the retailer opens secondary market under special circumstances .%提出零售商在一级市场生命周期末开辟二级市场的构想。在市场信息完全的前提下,根据消费者效用选择函数建立了双渠道供应链定价决策模型,并求解出零售商开辟二级市场后的零售商和制造商的最优定价。研究发现:分散式决策模式下,当一级市场仅有网络直销渠道,零售商不会开辟二级市场;当一级市场零售渠道和网络直销渠道都有需求,二级市场引入后的供应链成员利润可能实现Pareto改进;集中式决策模式下,只有一级市场零售渠道、网络直销渠道和二级市场都有需求且二级市场接受度超过临界值后,二级市场引入能提升供应链系统绩效。因此,零售商在特定条件下才会开辟二级市场。

  20. On the performance of dual-hop systems with multiple antennas: Effects of spatial correlation, keyhole, and co-channel interference

    KAUST Repository

    Yang, Liang

    2012-12-01

    In this paper, taking into account realistic propagation conditions, namely, spatial correlation, keyhole channels, and unequal-power co-channel interference, we investigate the performance of a wireless relay network where all the nodes are equipped with multiple antennas. Considering channel state information assisted amplify-and-forward protocol, we present analytical expressions for the symbol error rate (SER) and outage probability. More specifically, we first derive the SER expressions of a relay system with orthogonal space-time block coding (OSTBC) over correlated/keyhole fading channels. We also analyze the outage probability of interference corrupted relay systems with maximal ratio combing (MRC) at the receiver as well as multiple-input multiple-output MRC (MIMO MRC). Numerical results are given to illustrate and verify the analytical results. © 2012 IEEE.

  1. Design of Visible Light/Infrared Dual-channel Simulation Training Software%可见光/红外双通道模拟训练软件设计

    Institute of Scientific and Technical Information of China (English)

    贾雨生; 谢晓丹; 滕云飞

    2012-01-01

    针对目前国内作战模拟训练软件的仿真度不高和模式单一等问题,提出一种可见光/红外双通道作战模拟训练软件,对其视景仿真、通道切换、外部接口、运行过程进行设计,通过VC++.Net、Creator和Vega实现该软件.应用结果表明,该软件的场景类型多样、模型逼真、画质细腻、运行稳定,并且可在可见光/红外双通道下实现实时切换.%For the problems of simulation degree is low and mode is single which exist in the domestic combat simulation and training software, this paper presents a combat simulation and training software which works at visible light/infrared dual-channel, designs scene simulation, channel switch, outer interface and running process. It implements the software by VC++.Net, Creator and Vega. Application results show that the software's scenes are various, models are vivid, picture quality is exquisite, running is steady by application, and it can be switched between visible light and infrared channels real-time.

  2. Running at Double Pace: Women in Dual-Profession Marriages.

    Science.gov (United States)

    Arfken, Deborah Elwell

    Although the problems facing dual-profession couples are almost universally acknowledged, studies on dual-profession couples have only recently emerged from those on dual-worker or dual-career families. To explore the perceptions that women in dual-profession marriages have of their roles, conflicts, and coping strategies, focus group interviews…

  3. Average Fade Duration of Dual Selection Diversity over Correlated Unbalanced Nakagami-m Fading Channels in the Presence of Cochannel Interference

    Science.gov (United States)

    Panajotović, Aleksandra; Sekulović, Nikola; Drača, Dragan; Stefanović, Mihajlo; Stefanović, Časlav

    2013-12-01

    A dual selection combining (SC) receiver with correlated and unbalanced diversity branches operating in interference-limited Nakagami-m fading environment is considered in this paper. Actually, average fade duration (AFD) of SC system applying desired signal decision algorithm is obtained. Numerical results can be used to examine the effects of fading severity, input signal-to-interference ratio (SIR) unbalance and level of branch correlation on the AFD, as well as the correctness of proposed analytical formulation.

  4. The Price Strategy Research of Dual-channel Retail Enterprise%双重混合渠道下零售企业定价策略研究

    Institute of Scientific and Technical Information of China (English)

    蒋桂权; 包先建; 董冰灵

    2013-01-01

    This article analyses the optimal price from the perspective of the physical retailers' four kinds of pricing strategy based on three kinds of channel structure, and analyses when the network channel's price less than traditional channel's can be met. Numerical experiment is carried out for the pricing strategy D, and analyses the channel cost, the channel change coefficient of price differences and potential market impact on corporate profits under different conditions.%  从实体零售商的角度分析了四种定价策略下三种渠道结构的渠道最优价格,剖析了网络渠道价格小于传统渠道价格应满足的条件。同时对定价策略D做了数值试验,讨论了不同情况下渠道成本、渠道价格差异变动系数以及潜在市场定位对企业利润的影响。

  5. Review on Pricing Approach and Coordination Strategy of Dual-channel Supply Chain%双渠道供应链定价策略与协调机制研究综述

    Institute of Scientific and Technical Information of China (English)

    胡东波; 翟雯瑶

    2013-01-01

    梳理国内外相关文献,对双渠道供应链中的定价策略以及协调方法的研究现状进行综述,比较需求函数的影响因素,分类定价的不同策略,总结各种协调方法.在此基础上,展望未来的研究发展.%The paper reviews the relevant literature, overviews pricing approaches and coordinated strategies in the dual - channel supply chain, compares the influence factors of the demand function, classifies the pricing approaches and summarizes the various methods of coordination, the paper also researches the direction of future development in thie domain.

  6. 认知无线电网络双天线多信道媒体接入控制协议%Dual-antenna multi-channel MAC protocol in cognitive radio networks

    Institute of Scientific and Technical Information of China (English)

    黄巍; 钱裕乐; 李云

    2011-01-01

    在认知无线电网络中,媒体接入控制(MAC)协议的主要功能包括信道感知、选择和接入控制,其中感知时间和传输时间的长度对网络的性能有着重要的影响.提出了一种双天线多信道分布式认知无线电MAC(TM-MAC)协议,不需要在传输之前对信道进行感知;节点可以在其他节点传输数据的同时对频谱资源进行检测,然后利用空闲的频谱资源通信;建立了数学模型分析在饱和网络状况下MAC协议的吞吐量.仿真分析表明TM-MAC协议能够有效提高网络的吞吐量.%In the cognitive radio networks, the main functions of MAC protocols include channel sensing, channel selection and access, and the detection time and transmission time have important influence on network performance. A dual- antenna multi-channel distributed MAC (TM-MAC) protocol was proposed, which was not necessary to detect channels before transmitting nodes data. The node could detect the spectrum resource while other nodes transmit data. Then, the node could transmit data by the idle spectrum resource. A model was built to analyze the throughput of TM-MAC under the saturation condition. The simulation results show that TM-MAC improves the throughput in cognitive ratio networks.

  7. UWHS Climate Science: Uniting University Scientists and High School Teachers in the Development and Implementation of a Dual-Credit STEM-Focused Curriculum

    Science.gov (United States)

    Bertram, M. A.; Thompson, L.; Ackerman, T. P.

    2012-12-01

    The University of Washington is adapting a popular UW Atmospheric Sciences course on Climate and Climate Change for the high school environment. In the process, a STEM-focused teaching and learning community has formed. With the support of NASA Global Climate Change Education 20 teachers have participated in an evolving professional development program that brings those actively engaged in research together with high school teachers passionate about bringing a formal climate science course into the high school. Over a period of several months participating teachers work through the UW course homework and delve deeply into specific subject areas. Then, during a week-long summer institute, scientists bring their particular expertise (e.g. radiation, modeling) to the high school teachers through lectures or labs. Together they identify existing lectures, textbook material and peer-reviewed resources and labs available through the internet that can be used to effectively teach the UW material to the high school students. Through this process the scientists learn how to develop teaching materials around their area of expertise, teachers engage deeply in the subject matter, and both the university and high school teachers are armed with the tools to effectively teach a STEM-focused introductory course in climate science. To date 12 new hands-on modules have been completed or are under development, exploring ice-cores, isotopes, historical temperature trends, energy balance, climate models, and more. Two modules have been tested in the classroom and are ready for peer-review through well-respected national resources such as CLEAN or the National Earth Science Teachers Association; three others are complete and will be implemented in a high school classroom this year, and the remainder under various stages of development. The UWHS ATMS 211 course was piloted in two APES (Advanced Placement Environmental Science classrooms) in Washington State in 2011/2012. The high school

  8. HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy

    Science.gov (United States)

    Yan, Sijing; Lu, Min; Ding, Xiaoya; Chen, Fei; He, Xuemei; Xu, Chunyan; Zhou, Hang; Wang, Qi; Hao, Lan; Zou, Jianzhong

    2016-08-01

    This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV3 cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both in vitro and in vivo. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV3 cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic.

  9. HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy

    Science.gov (United States)

    Yan, Sijing; LU, Min; Ding, Xiaoya; Chen, Fei; He, Xuemei; Xu, Chunyan; Zhou, Hang; Wang, Qi; Hao, Lan; Zou, Jianzhong

    2016-01-01

    This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV3 cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both in vitro and in vivo. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV3 cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic. PMID:27535093

  10. 双参数估计的改进自聚焦算法%Imiproved auto-focus algorithm of dual parameters estimation

    Institute of Scientific and Technical Information of China (English)

    唐波

    2011-01-01

    To figure out the phase error in the high-resolution Synthetic Aperture Radar (SAR) imaging caused by using traditional auto-focus algorithm in which only velocity is considered, the quality of SAR image was analyzed when errors of two parameters of Doppler rate exist. One method of estimating both velocity and the nearest distance of range was proposed, which was based on the mathematic model that was much closer to the real, and this method could estimate the nearest range better. Finally, the testing data verify the effectiveness and applicability of the algorithm in the high-resolution SAR imaging.%传统自聚焦算法的多普勒调频率拟合模型中当最近斜距存在误差时,由于只考虑载机地速对多普勒调频率的影响,导致多普勒调频率拟合后会引入沿距离向变化的二次相位误差,该二次相位误差会严重影响高分辨率合成孔径雷达(SAR)成像的质量.为解决此问题,通过分析载机地速和最近斜距两个系统参数存在误差时对多频率调频率拟合的影响,提出了基于自聚焦算法结合最小二乘方法联合估计最近斜距和载机地速的双参数估计算法.该算法采用的估计模型相比于传统单参数估计算法更加符合真实的方位多普勒模型,在没有外定标的情况下可以很好地估计最近斜距误差.最后通过实测数据成像验证了该算法在高分辨率SAR成像中的有效性和适用性.

  11. Dual-mesoporous ZSM-5 zeolite with highly b-axis-oriented large mesopore channels for the production of benzoin ethyl ether.

    Science.gov (United States)

    Zhou, Xiaoxia; Chen, Hangrong; Zhu, Yan; Song, Yudian; Chen, Yu; Wang, Yongxia; Gong, Yun; Zhang, Guobin; Shu, Zhu; Cui, Xiangzhi; Zhao, Jinjin; Shi, Jianlin

    2013-07-22

    Dual-mesoporous ZSM-5 zeolite with highly b axis oriented large mesopores was synthesized by using nonionic copolymer F127 and cationic surfactant CTAB as co-templates. The product contains two types of mesopores--smaller wormlike ones of 3.3 nm in size and highly oriented larger ones of 30-50 nm in diameter along the b axis--and both of them interpenetrate throughout the zeolite crystals and interconnect with zeolite microporosity. The dual-mesoporous zeolite exhibits excellent catalytic performance in the condensation of benzaldehyde with ethanol and greater than 99 % selectivity for benzoin ethyl ether at room temperature, which can be ascribed to the zeolite lattice structure offering catalytically active sites and the hierarchical and oriented mesoporous structure providing fast access of reactants to these sites in the catalytic reaction. The excellent recyclability and high catalytic stability of the catalyst suggest prospective applications of such unique mesoporous zeolites in the chemical industry.

  12. Benefits of Dual Language Education

    Science.gov (United States)

    Wallstrum, Kiara

    2009-01-01

    The focus of this paper examines how dual language education (DLE) programs are valuable. The literature shows that children do much more than just thrive in a dual language environment. According to research, children who are bilingual are cognitively, academically, intellectually, socially and verbally more advantaged than their monolingual…

  13. A low-power 10-bit 250 MS/s dual-channel pipeline ADC in 0.18 μm CMOS

    Science.gov (United States)

    Fan, Q.; Chen, J.; Wen, X.; Feng, Y.; Tang, Y.; Zuo, Z.; Gong, D.; Liu, T.; Ye, J.

    2017-02-01

    This paper presents a 10-bit 250-MS/s time-interleaved pipelined analog-to-digital data converter (ADC). A distributed clocking scheme is developed to eliminate timing skew between channels without introducing load capacitance to the driving buffer of the ADC. The channel offset and gain mismatch errors are calibrated in digital domain. In addition, a switch-embedded opamp-sharing technique is developed to reduce the ADC power consumption and eliminate the memory effect. The simulated SNDR and SFDR are 61.84 dB and 78.2 dB, respectively. The ADC core consumes 28 mW under a 1.8 V supply at 250 MS/s sampling rate.

  14. Piezo-Phototronic Effect Controlled Dual-Channel Visible light Communication (PVLC) Using InGaN/GaN Multiquantum Well Nanopillars.

    Science.gov (United States)

    Du, Chunhua; Jiang, Chunyan; Zuo, Peng; Huang, Xin; Pu, Xiong; Zhao, Zhenfu; Zhou, Yongli; Li, Linxuan; Chen, Hong; Hu, Weiguo; Wang, Zhong Lin

    2015-12-02

    Visible light communication (VLC) simultaneously provides illumination and communication via light emitting diodes (LEDs). Keeping a low bit error rate is essential to communication quality, and holding a stable brightness level is pivotal for illumination function. For the first time, a piezo-phototronic effect controlled visible light communication (PVLC) system based on InGaN/GaN multiquantum wells nanopillars is demonstrated, in which the information is coded by mechanical straining. This approach of force coding is also instrumental to avoid LED blinks, which has less impact on illumination and is much safer to eyes than electrical on/off VLC. The two-channel transmission mode of the system here shows great superiority in error self-validation and error self-elimination in comparison to VLC. This two-channel PVLC system provides a suitable way to carry out noncontact, reliable communication under complex circumstances.

  15. Evaluation of the applicability of the dual-domain mass transfer model in porous media containing connected high-conductivity channels

    Science.gov (United States)

    Liu, Gaisheng; Zheng, C.; Gorelick, S.M.

    2007-01-01

    This paper evaluates the dual-domain mass transfer (DDMT) model to represent transport processes when small-scale high-conductivity (K) preferential flow paths (PFPs) are present in a homogenous porous media matrix. The effects of PFPs upon solute transport were examined through detailed numerical experiments involving different realizations of PFP networks, PFP/matrix conductivity contrasts varying from 10:1 to 200:1, different magnitudes of effective conductivities, and a range of molecular diffusion coefficients. Results suggest that the DDMT model can reproduce both the near-source peak and the downstream low-concentration spreading observed in the embedded dendritic network when there are large conductivity contrasts between high-K PFPs and the low-K matrix. The accuracy of the DDMT model is also affected by the geometry of PFP networks and by the relative significance of the diffusion process in the network-matrix system. Copyright 2007 by the American Geophysical Union.

  16. Online channel operation mode: Game theoretical analysis from the supply chain power structure

    Directory of Open Access Journals (Sweden)

    Song Huang

    2015-11-01

    Full Text Available Purpose: Dual-channels have been widely used in practice, and the pricing decisions and the online channel operation mode choice have been the core problems in dual-channel supply chain management. This paper focuses on the online channel operation mode choice from the supply chain power structures based on game theoretical analysis. Design/methodology/approach: This paper utilizes three kinds of game theoretical models to analyze the impact of supply chain power structures on the optimal pricing and online channel operation mode choice. Findings: Results derived in this paper indicate that when the self-price elasticity is large, the power structures have no direct impact on the decisions. However, when the self-price elasticity is small and customers’ preference for the online channel is low, then in the MS market, it is better for the retailer to operate the online channel, while in the RS market or in the VN market, it is better for the manufacturer to operate the online channel. Research limitations/implications: In this paper, we do not consider stochastic demand and asymmetric information, which may not well suit the reality. Originality/value: This paper provides a different perspective to analyze the impact of supply chain power structures on the pricing decisions and online channel operation mode choice. The comparison of these two online channel operation modes in this paper is also a unique point.

  17. Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY.

    Science.gov (United States)

    Kuzmenkov, Alexey I; Vassilevski, Alexander A; Kudryashova, Kseniya S; Nekrasova, Oksana V; Peigneur, Steve; Tytgat, Jan; Feofanov, Alexey V; Kirpichnikov, Mikhail P; Grishin, Eugene V

    2015-05-08

    The lesser Asian scorpion Mesobuthus eupeus (Buthidae) is one of the most widely spread and dispersed species of the Mesobuthus genus, and its venom is actively studied. Nevertheless, a considerable amount of active compounds is still under-investigated due to the high complexity of this venom. Here, we report a comprehensive analysis of putative potassium channel toxins (KTxs) from the cDNA library of M. eupeus venom glands, and we compare the deduced KTx structures with peptides purified from the venom. For the transcriptome analysis, we used conventional tools as well as a search for structural motifs characteristic of scorpion venom components in the form of regular expressions. We found 59 candidate KTxs distributed in 30 subfamilies and presenting the cysteine-stabilized α/β and inhibitor cystine knot types of fold. M. eupeus venom was then separated to individual components by multistage chromatography. A facile fluorescent system based on the expression of the KcsA-Kv1.1 hybrid channels in Escherichia coli and utilization of a labeled scorpion toxin was elaborated and applied to follow Kv1.1 pore binding activity during venom separation. As a result, eight high affinity Kv1.1 channel blockers were identified, including five novel peptides, which extend the panel of potential pharmacologically important Kv1 ligands. Activity of the new peptides against rat Kv1.1 channel was confirmed (IC50 in the range of 1-780 nm) by the two-electrode voltage clamp technique using a standard Xenopus oocyte system. Our integrated approach is of general utility and efficiency to mine natural venoms for KTxs.

  18. Pricing Strategy of Dual-Channel Supply Chain under Demand Uncertainty%需求不确定的双渠道供应链定价策略

    Institute of Scientific and Technical Information of China (English)

    曾敏刚; 王旭亮

    2013-01-01

    A supply chain composed of a manufacturer and a retailer is considered. This supply chain has two channels and its demands are subject to uncertainty in both channels. For such a supply chain, a model is built for pricing decision and coordination of the supply chain. With this model, analysis results show that the online price, wholesale price, and the retail price are influenced by consumer' s channel preference coefficient, demand uncertainty, and marginal cost of production. Also, comparative analysis is carried out between decentralized and centralized decision making modes. Then, a contract is presented for channel conflict remitting and profit sharing. Rational range of wholesale price is obtained. In the obtained wholesale price range, the lower the wholesale price is, the larger range of transfer payment the retailer presents to the manufacturer.%为了研究在需求不确定的环境下,双渠道供应链中制造商和零售商的定价策略和协调机制,建立了制造商主导型双渠道供应链的决策模型,同时考虑直销和传统2个渠道的需求不确定性.结果表明:消费者渠道偏好系数、渠道需求不确定性以及边际生产成本等变量对直销渠道价格、批发价格与传统渠道价格等定价策略具有确定影响关系.最后对比分析了分散式决策和集中式决策模式,提出一个使制造商和零售商缓解渠道冲突、实现共赢的二部线性契约,得到双方合作共赢的批发价格合理区间,并证明在合理区间内,合作批发价格越低,零售商向制造商提供的转移支付的可调整范围越大.

  19. 空间双通道电机噪声有源控制系统研究%Dual-channel Space Active Noise Control System for Motor Operating Noise

    Institute of Scientific and Technical Information of China (English)

    刘会灯; 邱阿瑞

    2011-01-01

    A dual-channel space active noise control (ANC) system was invesitaged to control opetating noise by a combined motors with a DC motor and an inducation motor. The experiments were conducted with four dual-channel ANC algorithms including Filter-x Least Mean Square (FxLMS) , Filter-u Recursive Least Mean Square (FuRLMS) , Hybrid FxLMS (HFxLMS) and Feedback FxLMS (FBFxLMS) to control the motor operating noise, and the results show that the average sound pressure level(SPL) reductions on the horizontal and vertical planes of the noise quiet zone are larger than 10dB when the DC motor operates at the speeds of 1300r/min, 1400r/min and 1500r/min. The maximum SPL reductions on the horizontal plane are 17. 92dB, 13. 28dB and 17. 88dB, while 16. 73dB, 16. 36dB and 16. 99dB on the vertical plane, respectively. The remarkable SPL reductions in the noise quiet zone show that the proposed dual-channel space ANC system can be effective to control the motor operating noise.%针对实验室一台直流电动机-同步发电机机组运行噪声的频谱特点,提出空间双通道有源噪声控制系统降低电机运行噪声.采用四种双通道控制算法(Ⅰ) FxLMS算法, (Ⅱ)FuRLMS算法, (Ⅲ)HFxLMS算法以及(Ⅳ) FBFxLMS算法进行电机运行噪声有源控制实验,对于电机运行转速分别为1300 r/min、1400 r/min和1500 r/min时,噪声控制区域内水平平面和垂直平面上平均声压级降低量均大于10 dB,水平平面上最大声压级降低量分别为17.92 dB、13.28 dB和17.88 dB,垂直平面上最大声压级降低量分别为16.73 dB、16.36 dB和16.99 dB,降噪效果表明本文提出的空间双通道有源控制系统能有效地降低电机运行噪声.

  20. 考虑消费者时间敏感的双渠道供应链竞争策略%Competitive strategy in dual-channel supply chain under the consumer time-sensitive

    Institute of Scientific and Technical Information of China (English)

    朱玉炜; 徐琪

    2013-01-01

    为研究网络直销与传统分销混合双渠道中消费者具有时间偏好情形下的供应链竞争问题,提出一种考虑消费者时间敏感性的定价和需求竞争策略.在该策略中,消费者时间偏好信息由制造商和零售商分别预测,并用时间敏感系数表示交付时间对消费者需求的影响程度.根据不同的时间敏感系数的预测值,考虑时间敏感系数确定和不确定两种情况,应用Bertrand博弈方法建立消费者时间敏感系数相关下的供应链定价及相应的需求模型.分析两个渠道的定价策略与消费者时间敏感系数的关系,以及消费者电子商务的接受程度对双渠道供应链竞争策略的影响.最后通过仿真算例分析制造商和零售商的消费者时间敏感系数的预测值对双渠道供应链收益的影响,以此说明该定价模型与需求竞争策略的有效性.%To study the supply chain competition problem with consumer time preference under dual channel of Internet direct marketing and traditional distribution,a pricing and demand competitive strategy considering consumer time-sensitive was proposed.In this strategy,the time preferences of consumer were predicted by retailer and manufacturer respectively,and a time sensitive coefficient was used to represent the influence degree of consumer needs by delivery time.According to different value of prediction time sensitive coefficient,two circumstances of certain and uncertain consumer time-sensitive coefficient were taken into consideration,the supply chain pricing model and the corresponding demand model considering the consumer time sensitive coefficient were established by applying Bertrand game method.The correlation between pricing strategy and consumer time-sensitive coefficient of two channels were analyzed,and the impact of E-business application level of consumers on dual channel supply chain operation was discussed.Simulation example was performed to analyze the influence of

  1. 双渠道环境下基于参考价格效应的制造商动态定价研究%Study on Manufacture's Dynamic Pricing of Reference Price Effect under Dual-channel

    Institute of Scientific and Technical Information of China (English)

    单汨源; 张瑞敏; 张人龙

    2014-01-01

    随着制造商日益盛行开辟网络直销渠道,双渠道环境下制造商的定价问题显得尤为重要。采用斯坦伯格博弈构建制造商在双渠道环境下基于参考价格效应的两阶段动态定价模型,并通过数值算例分析参考价格效应各参数对定价及整体收益的影响。研究结果表明:在双渠道环境中,批发价格与渠道交叉价格弹性系数、直销渠道的销售定价相关,间接受到参考价格效应影响;记忆系数和参考价格系数对制造商定价及收益的影响受到初始参考价格调节。%Currently,the problem of manufacturers'pricing has become very important,as manufacturers are more likely to develop their own online channel.The paper adopts the Stackelberg game to develop a two-stage dynamic pricing model,which based on the reference-price effect under the environment of dual-channel supply chain (the manufacturers sells their products via both online and traditional retail channels). Meanwhile,the numerical example method is used to analysis the impact of the reference-price effect param-eters on both pricing decision and the overall revenue.The research results show that the wholesale price de-pends on channel cross-price elasticity coefficient and the price in online sale,which will also be affected by reference-price effect indirectly.The memory coefficient and reference price coefficient affect the pricing de-cision and revenue with the adjustment of the initial reference price.

  2. Dual Rectangles

    CERN Document Server

    Everest, Graham

    2009-01-01

    This article has been written for an educational magazine whose target audience consists of students and teachers of mathematics in universities, colleges and schools. It concerns a notion of duality between rectangles. A proof is given that only finitely many integral sided pairs of dual rectangles exist. Then a geometrical group law is shown to hold on the set of all rational self-dual rectangles. Finally, the arithmetic of a cubic surface is used to construct new pairs of rational dual rectangles from old, a technique inspired by the theory of elliptic curves.

  3. 基于 NSCT与双通道 PCNN 的多聚焦图像融合%Multi-focus Image Fusion Method Based on NSCT and Dual PCNN

    Institute of Scientific and Technical Information of China (English)

    石学萍; 韩晓军; 张南; 王志宽; 武嘉庆

    2016-01-01

    为提高多聚焦图像的清晰度及PCNN在图像融合方面的实用性,提出一种基于NSCT与双通道PCNN的多聚焦图像融合新方法。首先对来自同一场景的多聚焦图像分别进行NSCT变换;然后将基于SML的视觉特性对比度用于低频子带系数的融合;对于高频子带则通过改进的空间频率激励双通道PCNN进行融合,两个通道对应不同的连接强度,根据点火次数确定高频子带融合系数;最后进行逆 NSCT 变换得到最终融合图像。实验结果表明,该融合算法得到的融合图像具有较高的清晰度,在主观和客观评价指标上优于其他算法,具有较好的视觉效果。%In order to improve the multi‐focus image sharpness and the practicability of PCNN in the aspect of image fusion ,a new multi‐focus image fusion method was proposed based on nonsubsampled Contourlet transform (NSCT) and dual‐channel pulse coupled neural network (DCPCNN) .Firstly ,multi‐focus images which from the same scene were decomposed using NSCT respectively ;and then visual properties contrast based on SML was used to fuse low frequency subband coefficients ;High frequency sub‐band component fused through DCPCNN which motivated by modified spatial frequency .DCPCNN had two channels corresponding to different linking strength , high frequency sub‐band fusion coefficient was determined according to the number of ignition .Finally ,the fusion image achieved by inverse transformation of NSCT . The experimental results demonstrate that the proposed algorithm improves fusion image sharpness significantly ,subjective and objective indicators are better than other fusion algorithms ,having better visual effects .

  4. 促销努力竞争情形下双渠道供应链协调策略%Coordination Strategies of the Dual Channel Supply Chain under Promotional Efforts Competition

    Institute of Scientific and Technical Information of China (English)

    马鹏; 王海燕

    2015-01-01

    The supply chain coordination with promotional effort-dependent demand is studied.The cen-tralized supply chain model and the decentralized supply chain model are respectively built.It is found that the wholesale price contract cannot coordinate the dual-channel supply chain while the modified wholesale price contract can.Then, the impacts of the manufacturer′s promotional effort coefficient, the retailer′s promotional effort coefficient and the customers′preference for direct channel on the supply chain perform-ance are investigated, and some numerical example and corresponding managerial meaning given.%研究需求依赖于促销努力水平下的供应链优化协调问题。分别建立了集中式供应链和分散式供应链两种模型,在分散式模型中,发现批发价格契约不能协调该双渠道供应链,而改进的批发价格契约可以协调该双渠道供应链。然后分别研究了制造商促销努力系数、零售商促销努力系数,以及顾客对直销渠道的接受度对供应链绩效的影响,并且进行了相关的算例分析,给出相应的管理意义。

  5. Physical mechanism of beam halo-chaos formation for high-current proton beam in a periodic-focusing channels and a nonlinear control strategy

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The physical mechanism of the halo-chaos formation for a high intensity proton beam in a periodic-fo cusing channel is analyzed using the transfer mahix theory and a qualiative analysis method.Particles-in-cell simula tims are further used to explore the mechanism of the beam halo-chaos fomation, which concerns not only with thc non linear effect of the beam space charge but also with the lransverse energy exchange belween the particles and the particle core. as well as the chaos generated by the nonlinear resonance ovcrlap. A nonlinear control method is proposed for con trolling tie haho-chaos. Simulation results show lhal the melhod is efhclivc. Somc potemlial applications of the halo chaos conlrol in experimenls are discussed.

  6. Pricing Strategies in Dual-channel Supply Chain with Retail Services and Customer Returns%考虑服务和退货的双渠道供应链定价问题研究

    Institute of Scientific and Technical Information of China (English)

    刘咏梅; 廖攀; 胡军华; 陈晓红

    2015-01-01

    This paper explores the optimal pricing strategies under the centralized and decentralized dual-channel supply chain concerning the retail services and customer returns using the two-stage optimization method and Stackelberg game.We show that the retail services contribute to enhancing the retail’ s channel power, and al-ways benefit the manufacturer.However, only when the service level is lower than a certain value can the manu-facturer and the retail get Pareto improvement at the same time.The retail prices and direct selling prices are positive related to the returns, but the relationship to the service level is subject to the influence of channel struc-ture.Although improving retail services can reduce retail channel’ s returns, returns become the problem that the whole supply chain members need to come together to solve.The retail services exacerbates the“double margin-alization” effect of the supply chain, and the manufacturer can mitigate this effect and improve the efficiency of supply chain by reducing return risks with producing products matching consumer needs.%在考虑零售服务和消费者退货情况下,运用两阶段优化方法分别探究了集中式和分散式两种双渠道供应链的最优定价策略。研究发现零售服务有助于提高零售商的渠道权力,并始终使制造商获益,但只有当服务水平小于某一临界值时,才使制造商和零售商同时得到帕累托改进。零售价格和直销价格与退货率正相关,而与服务水平的关系受渠道结构的影响。服务水平的提高加剧了供应链的“双重边际化”效应,制造商通过生产与消费者需求相匹配的产品来降低退货风险可以减弱这种效应,从而提高供应链效率。

  7. 双渠道供应链服务溢出下的协调策略%Coordination strategy in a dual-channel supply chain with service spillover effect

    Institute of Scientific and Technical Information of China (English)

    刘芹; 何彬斌; 吕郑超; 马媛

    2014-01-01

    文章基于Stackelberg主从对策模型,在零售商具有存在溢出效应服务投入的情况下,考虑了供应商和零售商的博弈过程,分别研究了传统单渠道和双渠道供应链的运作,并设计了收益共享合约使供应链达到协调;最后通过算例进行了分析验证和说明。结果表明:制造商是否开设直销渠道与零售商的服务溢出效应有关;供应链得以协调的条件是零售商应该支付给制造商一定的收益共享支付比例;供应链双方实现Pareto改进的条件是制造商付给零售商固定支付费用。%Based on the Stackelberg master-slave game model ,the game process of the suppliers and re-tailers under the condition of service spillover effect is considered .T he traditional single channel and the dual-channel supply chains are investigated respectively , and a revenue sharing contract is de-signed to coordinate the supply chain .The results show that whether the manufacturer will set up the direct channel or not depends on the service spillover effect of the retailer .The revenue sharing pay-ment proportion w hich retailers pay for manufacturers w hen the supply chain reaches the optimal prof-it integration is worked out .Then the fixed value scope of pay cost which manufacturers pay for re-tailers to satisfy both sides of supply chain to achieve Pareto improvement is also found out .Finally , the research conclusion is verified through the example analysis .

  8. 基于FPGA的双路高速数据采集系统的设计%Design of dual-channel super high-speed data acquisition system based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王瑶; 杨晓非

    2011-01-01

    以脉冲激光测距为应用背景,设计了1种双路1 Gsps采样率的高速数据采集系统的设计方案,该系统以EP2S60系列的FPGA为核心控制模块,ADC08D1000为模数转换芯片测量I、Q两路脉冲信号时间间隔.FPGA的资源分布决定ADC输出的两路信号(I、Q)需由FPGA的两侧共4个BANK接收,由此会造成系统测量的固定误差,利用ADC的并行交替采样模式修正该固定误差,大量测试数据表明,该系统能够实现双路1 Gsps的采样率,系统工作稳定且测量精度可控制在1 ns.%A design of a dual-channel data acquisition system with each channel up to 1 Gsps sampling rate based on the pulsed laser range finder was described in this paper. The system calculates time-interval between the two pulse signals of I and Q channel using EP2S60 serials FPGA and ADC08D1000 A/D coverter. For the distribution of the resources of the FPGA,the outputs of the ADC which are I and Q signal are received by two sides,four banks,of FPGA. Because of this,system errors are caused. By using the time-interleaved sampling mode of the ADC,a practical method to fix the errors is found. A series of testing prove that the sampling rate of the data acquisition system can be up to 1 Gsps,the system works stably and the precison of time-interval can be controlled in 1 ns.

  9. Free-electron laser generation of VUV and x-ray radiation using a conditioned beam and ion-channel focusing

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Li-Hua (Brookhaven National Lab., Upton, NY (United States)); Sessler, A.; Whittum, D.H. (Lawrence Berkeley Lab., CA (United States))

    1991-08-30

    The use of ion-focusing and a conditioned beam greatly enhances FEL gain in the VUV and Soft X-Ray range. The equations governing FEL amplification are derived and results of a linear analysis are noted. Numerical results, including 3D effects and having an order of magnitude improvement in gain, are presented for a 30 {Angstrom} example. 3 refs., 2 figs., 1 tab.

  10. L-type Ca(2+) channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes.

    Science.gov (United States)

    Kabir, Z D; Lee, A S; Rajadhyaksha, A M

    2016-10-15

    Brain Cav 1.2 and Cav 1.3 L-type Ca(2+) channels play key physiological roles in various neuronal processes that contribute to brain function. Genetic studies have recently identified CACNA1C as a candidate risk gene for bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder (MDD) and autism spectrum disorder (ASD), and CACNA1D for BD and ASD, suggesting a contribution of Cav 1.2 and Cav 1.3 Ca(2+) signalling to the pathophysiology of neuropsychiatric disorders. Once considered sole clinical entities, it is now clear that BD, SCZ, MDD and ASD share common phenotypic features, most likely due to overlapping neurocircuitry and common molecular mechanisms. A major future challenge lies in translating the human genetic findings to pathological mechanisms that are translatable back to the patient. One approach for tackling such a daunting scientific endeavour for complex behaviour-based neuropsychiatric disorders is to examine intermediate biological phenotypes in the context of endophenotypes within distinct behavioural domains. This will better allow us to integrate findings from genes to behaviour across species, and improve the chances of translating preclinical findings to clinical practice.

  11. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels.

    Science.gov (United States)

    De Petrocellis, Luciano; Di Marzo, Vincenzo

    2010-03-01

    The molecular mechanism of action of Delta(9)-tetrahydrocannabinol (THC), the psychotropic constituent of Cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid CB1 and CB2 receptors. However, while these latter proteins do mediate most of the pharmacological actions of THC, they do not seem to act as receptors for other plant cannabinoids (phytocannabinoids), nor are they the unique targets of the endogenous lipids that were originally identified in animals as agonists of CB1 and CB2 receptors, and named endocannabinoids. Over the last decade, several potential alternative receptors for phytocannabinoids, endocannabinoids, and even synthetic cannabimimetics, have been proposed, often based uniquely on pharmacological evidence obtained in vitro. In particular, the endocannabinoid anandamide, and the other most abundant Cannabis constituent, cannabidiol, seem to be the most "promiscuous" of these compounds. In this article, we review the latest data on the non-CB1, non-CB2 receptors suggested so far for endocannabinoids and plant or synthetic cannabinoids, and lay special emphasis on uncharacterized or orphan G-protein-coupled receptors as well as on transient receptor potential channels.

  12. Channel selection in e-commerce age: A strategic analysis of co-op advertising models

    Directory of Open Access Journals (Sweden)

    Yongmei Liu

    2013-03-01

    Full Text Available Purpose: The purpose of this paper is to develop and compare two co-op advertising models: advertising model under traditional channel and co-op advertising model under dual channel, to select optimal channel structure to sell products for manufacturer and to derive optimal co-op advertising strategies for the manufacturer and the retailer.Design/methodology/approach: Stackelberg game theoretical is used to develop two co-op advertising models: co-op advertising model under traditional channel and co-op advertising model under dual channel. Then we compare the two models to select optimal channel structure to sell products for manufacturer and to derive optimal co-op advertising strategies for the manufacturer and the retailer. Furthermore, we analyze the impact of product web-fit on these optimal strategies and illustrate by some numeral examples. Based on our results, we provide some significant theories and managerial insights, and derive some probable paths of future research.Findings: We provide a framework for researching optimal co-op advertising strategies in a two-level supply chain considering different marketing channel structures. First, we discuss the traditional channel co-op adverting model and the dual channel co-op advertising model based on Stackelberg game theoretical, and we derive optimal co-op advertising strategies. Next, comparisons of these two channel structures are discussed and we find that the manufacturer always benefits from dual channel. But the retailer not always benefits from dual channel structure, and dual channel structure is better than retail channel with certain conditions. Also, the optimal co-op advertising strategies for the manufacturer and the retailer are obtained.Research limitations/implications: First, we focus on the aforementioned two channel structures; a further comparison with other channel structures can be investigated. Second, we ignore some factors that influence the demand of product

  13. A Method to Improve the Performance of the Along-Track Interference Image in Dual-Channel Low Frequency SAR%提高双通道低频SAR干涉图性能的方法

    Institute of Scientific and Technical Information of China (English)

    范崇祎; 黄晓涛

    2012-01-01

    Along track interferometry (ATI) is an easy and efficient method to detect ground moving targets. In low frequency synthetic aperture radar (SAR) system, it is necessary to consider not only kinds of errors that will reduce the coherence of image pairs, but also the unsuppressed radio-frequency interference (RFI) left from the real-time imaging. This paper first analyzes the characteristic of each error in low frequency dual-channel SAR, comparing to those in the high frequency band system, and then analyzes the principle and characteristic of RFI on the interferometric image. A method to improve the performance of along-track interferometric image in low frequency SAR has been proposed further. This method can compensate the difference of receiver frequency, the difference of beam pattern, interferometric error and coregistration error, and use median filters in the azimuth-time range-frequency domain interferometric image to suppress the residual RFI with narrow bandwidth, varying with slow time and radiation angle. The first domestic real data with dual-channel low frequency SAR system has tested the effectiveness and feasibility of this method. It has shown that this method can be operated easily and efficiently with low computation, which is suitable for the real time processing of ATI.%沿航向干涉法是一种检测运动目标简单易行的有效方法.在低频双通道SAR系统中,为了保证干涉性能,不仅要考虑降低图像相干性的各类误差,还要考虑实时成像过程中残留的RFI对通道图像的影响.本文首先与高频系统中的误差进行比较,分析了影响低频双通道SAR系统的主要误差及其特点;其次分析了RFI对干涉图干扰的基本原理与特征,进而提出了一种提高双通道低频SAR干涉图性能的误差校正方法.该方法充分考虑了低频SAR系统的接收机频率特性误差、天线方向图误差、干涉相位误差及图像配准误差,利用基于方位时域距离频

  14. Dual diagnosis

    OpenAIRE

    2013-01-01

    Dual diagnosis denotes intertwining of intellectual disabilities with mental disorders. With the help of systematic examination of literature, intellectual disabilities are determined (they are characterized by subaverage intellectual activity and difficulties in adaptive skills), along side mental disorders. Their influence is seen in changes of thinking, perception, emotionality, behaviour and cognition. Mental disorders often occur with people with intellectual disabilities (data differs f...

  15. Numerical optimization of a three-channel radiofrequency coil for open, vertical-field, MR-guided, focused ultrasound surgery using the hybrid method of moment/finite difference time domain method.

    Science.gov (United States)

    Xin, Xuegang; Wang, Di; Han, Jijun; Feng, Yanqiu; Feng, Qianjin; Chen, Wufan

    2012-07-01

    The numerical optimization of a three-channel radiofrequency (RF) coil with a physical aperture for the open, vertical-field, MR-guided, focused ultrasound surgery (MRgFUS) system using the hybrid method of moment (MoM)/finite difference time domain (FDTD) method is reported. The numerical simulation of the current density distribution on an RF coil with a complicated irregular structure was performed using MoM. The electromagnetic field simulation containing the full coil-tissue interactions within the region of interest was accomplished using the FDTD method. Huygens' equivalent box with six surfaces smoothly connected the MoM and FDTD method. An electromagnetic model of the human pelvic region was reconstructed and loaded in the FDTD zone to optimize the three-channel RF coil and compensate for the lower sensitivity at the vertical field. In addition, the numerical MoM was used to model the resonance, decoupling and impedance matching of the RF coil in compliance with engineering practices. A prototype RF coil was constructed to verify the simulation results. The results demonstrate that the signal-to-noise ratio and the homogeneity of the B(1) field were both greatly improved compared with previously published results.

  16. QCD Dual

    DEFF Research Database (Denmark)

    Sannino, Francesco

    2009-01-01

    We uncover a novel solution of the 't Hooft anomaly matching conditions for QCD. Interestingly in the perturbative regime the new gauge theory, if interpreted as a possible QCD dual, predicts the critical number of flavors above which QCD in the nonperturbative regime, develops an infrared stable...... fixed point. Remarkably this value is identical to the maximum bound predicted in the nonpertubative regime via the all-orders conjectured beta function for nonsupersymmetric gauge theories.......We uncover a novel solution of the 't Hooft anomaly matching conditions for QCD. Interestingly in the perturbative regime the new gauge theory, if interpreted as a possible QCD dual, predicts the critical number of flavors above which QCD in the nonperturbative regime, develops an infrared stable...

  17. Research on cooperative advertising decisions in a dual-channel supply chain under asymmetric demand information%需求信息不对称下的双渠道供应链合作广告投资决策分析

    Institute of Scientific and Technical Information of China (English)

    杨磊; 纪静娜; 张智勇

    2015-01-01

    This paper analyzes the advertising decisions in a dual-channel supply chain involved one manufacturer and one retailer. A Stackelberg game dominated by the manufacturer is established. The influence of asymmetric demand information and dual-channel on the cooperative advertising decisions is analyzed. The study shows that the retailer will lie about the demand when it has demand information advantages. Under certain conditions, the optimal lied strategy would decrease manufacturer's profit but increase the profit of the supply chain. Under such circumstances, the manufacturer could not use the incentive contract to encourage the retailer to share demand information. In addition, when the market share proportion between direct sales channel and distribution channel is less than a certain value, the introduction of direct sales channel can be beneficial to both the supply chain participants under optimal advertising strategies.%研究制造商主导的Stackelberg博弈下双渠道供应链的合作广告策略,分析信息不对称及双渠道对供应链合作广告投资决策的影响.研究表明,零售商在具有需求信息优势时会谎报需求信息,并且在一定条件下其谎报决策会降低制造商的利润,但能提高供应链的利润,这种情况下制造商无法通过激励合同促使零售商共享信息.另外,在最优合作广告策略下,当直销渠道与分销渠道所占市场份额的分配比例小于一定值时,制造商采取双渠道会使供应链参与者均受益.

  18. Coordination Pricing Model of Dual-channel Closed-loop Supply Chain Considering Retailer Collection%考虑零售商回收的双渠道闭环供应链协调定价模型

    Institute of Scientific and Technical Information of China (English)

    刘昊; 王志平

    2016-01-01

    A dual-channel closed-loop supply chain game model with manufacturer performing online sales and retailer carrying out traditional retail and recycling waste products was established under the context of E-commerce. We calculate the optimal pricing strategy of supply chain members under centralized dicision-making and decentralized dicision-making respectively. Moreover, we design a profit and expense sharing contract basing on the benchmark of the optimal result of centralized decision-making, namely that the manufacturers share part of the sales profits of manufacturers and retailers, at the same time pay for part of the retailer's recovery, in this way the supply chain system with decentralized decision-making mode could be coordinated. Last but not least, we verify the effectiveness of our proposed coordination pricing mechanism through a case study.%构造了电子商务环境下制造商开通网上直销渠道,零售商进行传统零售并且对废旧产品进行回收的双渠道闭环供应链博弈模型。分别计算了集中决策和分散决策下供应链各节点企业的最优定价策略,然后以集中决策下的最优定价策略为基准,通过设计一份收益共享—费用分担契约,即制造商分享一部分制造商和零售商的销售总利润,同时承担一部分零售商的回收费用,从而实现了分散决策下供应链系统的协调。最后,通过算例分析,验证了该契约的有效性。

  19. Prototype construction of a dual-channel 3D many-core NoC based on KILL rule%基于KILL规则的双通道3D众核NoC原型构建

    Institute of Scientific and Technical Information of China (English)

    谭海

    2013-01-01

    In order to design a low-delay and low-overhead many-core Network-on-Chip (NoC),the paper proposes an Architecture Utilizing 3D Stack Hierarchical Dual-channel NoC (AUSHDN) and KILL(Kill If Less Linear)rule is used to determine the number of processing cores in each group of AUSHDN.What's more,the prototype of the AUSHDN system is established based on the Graphite simulator from MIT.In AUSGHN system,3D stack Hierarchical multilevel internet-on-chip is employed and different communication link is used to transfer control and data signal according to different content of communication.The results of simulation test in prototype system show that:compared with the traditional 2D NOC,the power consumption has reduced by 20% and the time delay has shortened by 30%.Meanwhile,the hierarchy feature of the AUSGHN system guarantees its good scalability.%为设计一个低开销低时延的众核NoC系统,提出了一种使用3D叠片技术的双通道片上众核体系AUTSDN,应用KILL规则确定了片上众核中组内处理核的个数,并基于MIT的Graphite模拟器建立了该体系的原型.AUTSDN体系中采用3D叠片分组多级片上互连网络,并且根据通信内容的不同,控制信号和数据信号的传输采取不同的通信链路.原型系统中的模拟测试结果表明,相比传统的2D片上网络,功耗降低了20%,时延降低了30%,同时AUTSDN的系统层次化特征确保了良好的系统扩展性.

  20. Dual-Schemata Model

    Science.gov (United States)

    Taniguchi, Tadahiro; Sawaragi, Tetsuo

    In this paper, a new machine-learning method, called Dual-Schemata model, is presented. Dual-Schemata model is a kind of self-organizational machine learning methods for an autonomous robot interacting with an unknown dynamical environment. This is based on Piaget's Schema model, that is a classical psychological model to explain memory and cognitive development of human beings. Our Dual-Schemata model is developed as a computational model of Piaget's Schema model, especially focusing on sensori-motor developing period. This developmental process is characterized by a couple of two mutually-interacting dynamics; one is a dynamics formed by assimilation and accommodation, and the other dynamics is formed by equilibration and differentiation. By these dynamics schema system enables an agent to act well in a real world. This schema's differentiation process corresponds to a symbol formation process occurring within an autonomous agent when it interacts with an unknown, dynamically changing environment. Experiment results obtained from an autonomous facial robot in which our model is embedded are presented; an autonomous facial robot becomes able to chase a ball moving in various ways without any rewards nor teaching signals from outside. Moreover, emergence of concepts on the target movements within a robot is shown and discussed in terms of fuzzy logics on set-subset inclusive relationships.

  1. Population thinking and natural selection in dual-inheritance theory

    OpenAIRE

    Houkes, WN Wybo

    2012-01-01

    A deflationary perspective on theories of cultural evolution, in particular dual-inheritance theory, has recently been proposed by Lewens. On this ‘pop-culture’ analysis, dual-inheritance theorists apply population thinking to cultural phenomena, without claiming that cultural items evolve by natural selection. This paper argues against this pop-culture analysis of dual-inheritance theory. First, it focuses on recent dual-inheritance models of specific patterns of cultural change. These model...

  2. Ion channels in asthma.

    Science.gov (United States)

    Valverde, Miguel A; Cantero-Recasens, Gerard; Garcia-Elias, Anna; Jung, Carole; Carreras-Sureda, Amado; Vicente, Rubén

    2011-09-23

    Ion channels are specialized transmembrane proteins that permit the passive flow of ions following their electrochemical gradients. In the airways, ion channels participate in the production of epithelium-based hydroelectrolytic secretions and in the control of intracellular Ca(2+) levels that will ultimately activate almost all lung cells, either resident or circulating. Thus, ion channels have been the center of many studies aiming to understand asthma pathophysiological mechanisms or to identify therapeutic targets for better control of the disease. In this minireview, we focus on molecular, genetic, and animal model studies associating ion channels with asthma.

  3. Dynamic focusing in the zebrafish beating heart

    Science.gov (United States)

    Andrés-Delgado, L.; Peralta, M.; Mercader, N.; Ripoll, J.

    2016-03-01

    Of the large amount of the animal models available for cardiac research, the zebrafish is extremely valuable due to its transparency during early stages of development. In this work a dual illumination laser sheet microscope with simultaneous dual camera imaging is used to image the beating heart at 200 fps, dynamically and selectively focusing inside the beating heart through the use of a tunable lens. This dual color dynamic focusing enables imaging with cellular resolution at unprecedented high frame rates, allowing 3D imaging of the whole beating heart of embryonic zebrafish.

  4. Study on real-time registration in dual spectrum low level light night vision technique

    Science.gov (United States)

    Bai, Lian-fa; Zhang, Yi; Zhang, Chuang; Chen, Qian; Gu, Guo-hua

    2009-07-01

    In low level light (LLL) color night vision technology, dual spectrum images with respective special information were acquired, and target identification probability would be effectively improved through dual spectrum image fusion. Image registration is one of the key technologies during this process. Current dual spectrum image registration methods mainly include dual imaging channel common optical axis scheme and image characteristic pixel searching scheme. In dual imaging channel common optical axis scheme, additional prismatic optical components should be used, and large amount of radiative energy was wasted. In image characteristic pixel searching scheme, complicated arithmetic made it difficult for its real time realization. In this paper, dual channel dual spectrum LLL color night vision system structure feature and dual spectrum image characteristics was studied, dual spectrum image gray scale symbiotic matrix 2-dimensional histogram was analysed, and a real time image registration method including electronic digital shifting, pixel extension and extraction was put forward. By the analysis of spatial gray-scale relativity of fusion image, registration precision is quantitatively expressed. Emulation experiments indicate that this arithmetic is fast and exact for our dual channel dual spectrum image registration. This method was realized on dual spectrum LLL color night vision experimental apparatus based on Texas Instruments digital video processing device DM642.

  5. Stay Focused! The Effects of Internal and External Focus of Attention on Movement Automaticity in Patients with Stroke.

    Science.gov (United States)

    Kal, E C; van der Kamp, J; Houdijk, H; Groet, E; van Bennekom, C A M; Scherder, E J A

    2015-01-01

    Dual-task performance is often impaired after stroke. This may be resolved by enhancing patients' automaticity of movement. This study sets out to test the constrained action hypothesis, which holds that automaticity of movement is enhanced by triggering an external focus (on movement effects), rather than an internal focus (on movement execution). Thirty-nine individuals with chronic, unilateral stroke performed a one-leg-stepping task with both legs in single- and dual-task conditions. Attentional focus was manipulated with instructions. Motor performance (movement speed), movement automaticity (fluency of movement), and dual-task performance (dual-task costs) were assessed. The effects of focus on movement speed, single- and dual-task movement fluency, and dual-task costs were analysed with generalized estimating equations. Results showed that, overall, single-task performance was unaffected by focus (p = .341). Regarding movement fluency, no main effects of focus were found in single- or dual-task conditions (p's ≥ .13). However, focus by leg interactions suggested that an external focus reduced movement fluency of the paretic leg compared to an internal focus (single-task conditions: p = .068; dual-task conditions: p = .084). An external focus also tended to result in inferior dual-task performance (β = -2.38, p = .065). Finally, a near-significant interaction (β = 2.36, p = .055) suggested that dual-task performance was more constrained by patients' attentional capacity in external focus conditions. We conclude that, compared to an internal focus, an external focus did not result in more automated movements in chronic stroke patients. Contrary to expectations, trends were found for enhanced automaticity with an internal focus. These findings might be due to patients' strong preference to use an internal focus in daily life. Future work needs to establish the more permanent effects of learning with different attentional foci on re-automating motor control

  6. Channel Statistics for MIMO Handsets in Data Mode

    DEFF Research Database (Denmark)

    Nielsen, Jesper Ødum; Yanakiev, Boyan; Barrio, Samantha Caporal Del;

    2014-01-01

    The presented work is based on a large dual- band, dual-base outdoor-to-indoor multiple-input multiple- output (MIMO) channel measurement campaign, involving ten different realistic MIMO handsets, held in data mode by eight test users. Various different use cases (UCs) are measured. Statistics on...... on the channel capacity, mean effective gain (MEG), branch power ratio (BPR), and correlation coefficients between Rx, Tx, and cross-link channels are presented....

  7. TRP channels in schistosomes

    Directory of Open Access Journals (Sweden)

    Swarna Bais

    2016-12-01

    Full Text Available Praziquantel (PZQ is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this fact, only a few classes of parasitic helminth ion channels have been assessed for their pharmacological properties or for their roles in parasite physiology. One such overlooked group of ion channels is the transient receptor potential (TRP channel superfamily. TRP channels share a common core structure, but are widely diverse in their activation mechanisms and ion selectivity. They are critical to transducing sensory signals, responding to a wide range of external stimuli. They are also involved in other functions, such as regulating intracellular calcium and organellar ion homeostasis and trafficking. Here, we review current literature on parasitic helminth TRP channels, focusing on those in schistosomes. We discuss the likely roles of these channels in sensory and locomotor activity, including the possible significance of a class of TRP channels (TRPV that is absent in schistosomes. We also focus on evidence indicating that at least one schistosome TRP channel (SmTRPA has atypical, TRPV1-like pharmacological sensitivities that could potentially be exploited for future therapeutic targeting.

  8. Quantum broadcast channels

    CERN Document Server

    Yard, J; Devetak, I; Yard, Jon; Hayden, Patrick; Devetak, Igor

    2006-01-01

    We analyze quantum broadcast channels, which are quantum channels with a single sender and many receivers. Focusing on channels with two receivers for simplicity, we generalize a number of results from the network Shannon theory literature which give the rates at which two senders can receive a common message, while a personalized one is sent to one of them. Our first collection of results applies to channels with a classical input and quantum outputs. The second class of theorems we prove concern sending a common classical message over a quantum broadcast channel, while sending quantum information to one of the receivers. The third group of results we obtain concern communication over an isometry, giving the rates at quantum information can be sent to one receiver, while common quantum information is sent to both, in the sense that tripartite GHZ entanglement is established. For each scenario, we provide an additivity proof for an appropriate class of channels, yielding single-letter characterizations of the...

  9. Ion focusing

    Energy Technology Data Exchange (ETDEWEB)

    Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping

    2017-01-17

    The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

  10. 双渠道供应链的产品互补合作策略研究%A Collaboration strategy for Complementary Products in Dual-channel Supply Chains

    Institute of Scientific and Technical Information of China (English)

    但斌; 肖剑; 张旭梅

    2011-01-01

    Direct gales channels are proliferating along with the rapid development of the Internet because they allow manufacturers to reduce transaction costs and manage channels. Direct sales channels are weakening the traditional retail channels and inviting competition from them. It is important for manufacturers to receive support from retailers by addressing the needs of retailers and dealing with channel conflicts.If direct sales channels and retail channels have complementary relationships and channel products can complement with each other, conflicts between the two sides can be mitigated. Channel conflicts can be reduced if direct sales and retail channels can collaborate and complement with each other. For instance, direct sales channels can help promote ancillary products, such as software, peripheral devices, and portable computer bags, for computer retailers.We adopt Bertrand' s game model of channel-product complementary cooperation to analyze complementary strategies for channelproducts. The model assumes that manufacturers and retailers are of equal size. We discover that if consumers are sensitive to targetproduct' s channel price, target product' s channel price will drop, the price of complementary goods will increase, and the demandand benefits of direct sales channels will decrease. The same logic can be applied to increasing the sales of retailer' s complement' products and profits if customers are sensitive to price of complementary goods.We further provide numerical evidence showing that an effective channel product complementary strategy is for retailers to choose right complementary products to sell in traditional retail channels. We also find that the higher the substitution coefficient of a manufacturer' s products the more mutual benefits channels of both target and complementary products can realize. This study is concluded with further research directions on information asymmetry, as well as complementary and alternative products.%在供应

  11. Dual massive gravity

    Energy Technology Data Exchange (ETDEWEB)

    Morand, Kevin, E-mail: Kevin.Morand@lmpt.univ-tours.fr [Laboratoire de Mathematiques et Physique Theorique, Universite Francois-Rabelais Tours, Federation Denis Poisson - CNRS, Parc de Grandmont, 37200 Tours (France); Solodukhin, Sergey N., E-mail: Sergey.Solodukhin@lmpt.univ-tours.fr [Laboratoire de Mathematiques et Physique Theorique, Universite Francois-Rabelais Tours, Federation Denis Poisson - CNRS, Parc de Grandmont, 37200 Tours (France)

    2012-08-29

    The linearized massive gravity in three dimensions, over any maximally symmetric background, is known to be presented in a self-dual form as a first order equation which encodes not only the massive Klein-Gordon type field equation but also the supplementary transverse-traceless conditions. We generalize this construction to higher dimensions. The appropriate dual description in d dimensions, additionally to a (non-symmetric) tensor field h{sub {mu}{nu}}, involves an extra rank-(d-1) field equivalently represented by the torsion rank-3 tensor. The symmetry condition for h{sub {mu}{nu}} arises on-shell as a consequence of the field equations. The action principle of the dual theory is formulated. The focus has been made on four dimensions. Solving one of the fields in terms of the other and putting back in the action one obtains two other equivalent formulations of the theory in which the action is quadratic in derivatives. In one of these representations the theory is formulated entirely in terms of a rank-2 non-symmetric tensor h{sub {mu}{nu}}. This quadratic theory is not identical to the Fierz-Pauli theory and contains the coupling between the symmetric and antisymmetric parts of h{sub {mu}{nu}}. Nevertheless, the only singularity in the propagator is the same as in the Fierz-Pauli theory so that only the massive spin-2 particle is propagating. In the other representation, the theory is formulated in terms of the torsion rank-3 tensor only. We analyze the conditions which follow from the field equations and show that they restrict to 5 degrees of freedom thus producing an alternative description to the massive spin-2 particle. A generalization to higher dimensions is suggested.

  12. Performance Comparative Study in Dual-Distribution Channel Drop Shipping Supply Chain Based on Different Dominant Positions%不同主导权位置情况下零售商双渠道策略的绩效对比研究

    Institute of Scientific and Technical Information of China (English)

    赵金实; 段永瑞; 王世进; 霍佳震

    2013-01-01

    the retailer-led supply chain, the retailer decides the order quantity, commitment fee and wholesale price of drop shipping to optimize profit for itself and the whole supply chain. The supplier decides its production quantity. We assume that the drop shipper has no production capacity limit. We focus on such complicated dual channel and drop shipping supply chain. First, we consider the coordination in decentralized and centralized contexts. Second, we propose the commitment contracts for both supplier-led and retailer-led supply chain scenarios. We compare supplier-led supply chain with retailer-led supply chain. Our analysis shows that supply chain members can take advantage of dominant positions to receive more profit. The supplier can receive more profit in supplier-led supply chain than retailer-led supply chain. In contrast, the retailer receives more profit in retailer-led supply chain than supplier-led supply chain. Because of incentives from retailer, the production quantity of supplier in the retailer-led supply chain is greater than that in the supplier-led supply chain. This finding can help explain that dominant retailers usually lead to excess production capacity as observed in China.%当前传统零售商纷纷发展在线销售渠道并广泛采用供应商代发货的经营模式,这进—步增强了零售商的终端优势.以家电和快速消费品为代表的行业中,零售商正在逐步从生产商手中夺取主导权,零售商与供应商的关系受到供应链主导权位置的影响而变得更加复杂.本文针对这种复杂供应链现实问题,开发出包含承诺费的零售商双渠道协调机制,计算获得供应商主导和零售商主导两种不同情况下的供应链协调优化策略.通过对比供应商主导和零售商主导供应链的利润构成情况,我们发现供应链成员可以通过主导权为自己谋取更大利润;供应商主导型供应链的整体利润水平高于零售商主导型供应链.原

  13. Dual-Polarized Planar Phased Array Analysis for Meteorological Applications

    Directory of Open Access Journals (Sweden)

    Chen Pang

    2015-01-01

    Full Text Available This paper presents a theoretical analysis for the accuracy requirements of the planar polarimetric phased array radar (PPPAR in meteorological applications. Among many factors that contribute to the polarimetric biases, four factors are considered and analyzed in this study, namely, the polarization distortion due to the intrinsic limitation of a dual-polarized antenna element, the antenna pattern measurement error, the entire array patterns, and the imperfect horizontal and vertical channels. Two operation modes, the alternately transmitting and simultaneously receiving (ATSR mode and the simultaneously transmitting and simultaneously receiving (STSR mode, are discussed. For each mode, the polarimetric biases are formulated. As the STSR mode with orthogonal waveforms is similar to the ATSR mode, the analysis is mainly focused on the ATSR mode and the impacts of the bias sources on the measurement of polarimetric variables are investigated through Monte Carlo simulations. Some insights of the accuracy requirements are obtained and summarized.

  14. K(v)7 channels: function, pharmacology and channel modulators.

    Science.gov (United States)

    Dalby-Brown, William; Hansen, Henrik H; Korsgaard, Mads P G; Mirza, Naheed; Olesen, Søren-P

    2006-01-01

    K(v)7 channels are unique among K(+) channels, since four out of the five channel subtypes have well-documented roles in the development of human diseases. They have distinct physiological functions in the heart and in the nervous system, which can be ascribed to their voltage-gating properties. The K(v)7 channels also lend themselves to pharmacological modulation, and synthetic openers as well as blockers of the channels, regulating neuronal excitability, have existed even before the K(v)7 channels were identified by cloning. In the present review we give an account on the focused efforts to develop selective modulators, openers as well as blockers, of the K(v)7 channel subtypes, which have been undertaken during recent years, along with a discussion of the K(v)7 ion channel physiology and therapeutic indications for modulators of the neuronal K(v)7 channels.

  15. Differential Effects of TRPA and TRPV Channels on Behaviors of Caenorhabditis elegans

    Science.gov (United States)

    Thies, Jennifer; Neutzler, Vanessa; O’Leary, Fidelma; Liu, He

    2016-01-01

    TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions. In Caenorhabditis elegans, the TRPV channels are known to affect chemosensation, while the TRPA-1 channel is associated with thermosensation and mechanosensation. We examined thermosensation, chemosensation, and osmosensation in strains lacking TRPA-1 or TRPV channels. We found that TRPV channel knockout worms exhibited similar behavioral deficits associated with thermotaxis as the TRPA-1 channel knockout, suggesting a dual role for TRPV channels. In contrast, chemosensation responses, assessed by both avoidance reversal behavior and NaCl osmosensation, were dependent on TRPV channels but seemed independent of TRPA-1 channel. Our findings suggest that, in addition to TRPA-1 channel, TRPV channels are necessary for thermotaxis and may activate, or modulate, the function of TRPA-1 channels. In contrast, TRPA-1 channels do not have a dual responsibility, as they have no functional role in odorant avoidance or osmosensation. PMID:27168724

  16. Without 'Focus'

    Directory of Open Access Journals (Sweden)

    Aldo Sevi

    2010-12-01

    Full Text Available It is widely accepted that a notion of 'focus', more or less as conceived of in Jackendoff (1972, must be incorporated into our theory of grammar, as a means of accounting for certain observed correlations between prosodic facts and semantic/pragmatic facts. In this paper, we put forth the somewhat radical idea that the time has come to give up this customary view, and eliminate 'focus' from our theory of grammar. We argue that such a move is both economical and fruitful.Research over the years has revealed that the correlations between prosody, 'focus', and the alleged semantic/pragmatic effects of focus are much less clear and systematic than we may have initially hoped. First we argue that this state of affairs detracts significantly from the utility of our notion of 'focus', to the point of calling into question the very motivation for including it in the grammar. Then we look at some of the central data, and show how they might be analyzed without recourse to a notion of 'focus'. We concentrate on (i the effect of pitch accent placement on discourse congruence, and (ii the choice of 'associate' for the so-called 'focus sensitive' adverb only. We argue that our focus-free approach to the data improves empirical coverage, and begins to reveal patterns that have previously been obscured by preconceptions about 'focus'.ReferencesBeaver, D. & Clark, B. 2008. Sense and Sensitivity: How Focus Determines Meaning. Blackwell.Beaver, D., Clark, B., Flemming, E., Jaeger, T. F. & Wolters, M. 2007. ‘When semantics meets phonetics: Acoustical studies of second occurrence focus’. Language 83.2: 245–76.http://dx.doi.org/10.1353/lan.2007.0053Beckman, M. & Hirschberg, J. 1994. ‘The ToBI Annotation Conventions’. Ms.,http://www.cs.columbia.edu/~julia/files/conv.pdf.Bolinger, D. 1972. ‘Accent is predictable (if you are a mind-reader’. Language 48.3: 633–44.http://dx.doi.org/10.2307/412039Büring, D. 2006. ‘Focus projection and default

  17. Volume Regulated Channels

    DEFF Research Database (Denmark)

    Klausen, Thomas Kjær

    - serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...... of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume......, controlled cell death and cellular migration. Volume regulatory mechanisms has long been in focus for regulating cellular proliferation and my thesis work have been focusing on the role of Cl- channels in proliferation with specific emphasis on ICl, swell. Pharmacological blockage of the ubiquitously...

  18. Dual-channel Recycling Model of Waste Electrical and Electronic Equipment and Research on Effects of Government Subsidy%废旧电器电子产品双渠道回收模型及政府补贴作用研究

    Institute of Scientific and Technical Information of China (English)

    刘慧慧; 黄涛; 雷明

    2013-01-01

    目前我国的大部分废旧电器电子产品没有得到环保回收,回收市场上存在以有拆解资质的回收处理商为主导的正规渠道和无拆解资质的回收处理商主导的非正规渠道.鉴于此,本文建立了双渠道回收竞争模型,刻画了两种渠道各自的回收处理途径和盈利模式,给出了均衡时的回收价格和翻修比例,讨论了不同竞争情景下政府补贴的影响.结果发现当补贴额度较低时,政府补贴可以有效刺激回收量的增长、扶持正规企业的发展,但随着补贴的提升,补贴对回收总量的刺激作用减弱.研究还发现当翻修品价格较高时,旧货市场的存在可以帮助正规企业牵制非正规拆解商的发展,同时提高翻修质量门槛可以限制废旧品流向非正规处理渠道.%Most of waste electrical and electronic equipments have not been recycled and reused in an environment-friendly manner in China mainland where there exist two kinds of recycling channels: a regular channel with official qualification for disassembling e-waste products and an irregular channel without qualification. A dual-channel recycling model is built in this paper to describe price competition between qualified and unqualified recyclers in two channels which have different e-waste disposal approaches, and shows equilibrium recycling price and reusing ratio. Five competing scenarios and single-channel structure are discussed to explore the effects of government subsidy in two channels. Finally sensitivity analysis of parameters and numerical simulation are provided. It is found that when government subsidy is low, it can motivate the acquisition amount of e-waste products to increase greatly and help qualified recyclers win greater market share, however as subsidy increases, its role in promoting recycling reduces. To render the irregular channel absent from recycling market, the government needs to pay an extremely high subsidy fee. It is also found when the

  19. Dual optical marker Raman characterization of strained GaN-channels on AlN using AlN/GaN/AlN quantum wells and {sup 15}N isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Qi, Meng; Li, Guowang; Protasenko, Vladimir; Zhao, Pei; Verma, Jai; Song, Bo; Ganguly, Satyaki; Zhu, Mingda; Hu, Zongyang; Yan, Xiaodong; Xing, Huili Grace; Jena, Debdeep, E-mail: djena@nd.edu [Electrical Engineering, University of Notre Dame, Notre Dame, Indiana 46556 (United States); Mintairov, Alexander [Electrical Engineering, University of Notre Dame, Notre Dame, Indiana 46556 (United States); Ioffe Physico-Technical Institute, Russian Academy of Sciences, Saint Petersburg 194021 (Russian Federation)

    2015-01-26

    This work shows that the combination of ultrathin highly strained GaN quantum wells embedded in an AlN matrix, with controlled isotopic concentrations of Nitrogen enables a dual marker method for Raman spectroscopy. By combining these techniques, we demonstrate the effectiveness in studying strain in the vertical direction. This technique will enable the precise probing of properties of buried active layers in heterostructures, and can be extended in the future to vertical devices such as those used for optical emitters and for power electronics.

  20. Focus: Digital

    DEFF Research Database (Denmark)

    Technology has been an all-important and defining element within the arts throughout the 20th century, and it has fundamentally changed the ways in which we produce and consume music. With this Focus we investigate the latest developments in the digital domain – and their pervasiveness and rapid...... production and reception of contemporary music and sound art. With ‘Digital’ we present four composers' very different answers to how technology impact their work. To Juliana Hodkinson it has become an integral part of her sonic writing. Rudiger Meyer analyses the relationships between art and design and how...

  1. Molecular basis of potassium channels in pancreatic duct epithelial cells

    DEFF Research Database (Denmark)

    Hayashi, M.; Novak, Ivana

    2013-01-01

    Potassium channels regulate excitability, epithelial ion transport, proliferation, and apoptosis. In pancreatic ducts, K channels hyperpolarize the membrane potential and provide the driving force for anion secretion. This review focuses on the molecular candidates of functional K channels...

  2. Sensing with Ion Channels

    CERN Document Server

    Martinac, Boris

    2008-01-01

    All living cells are able to detect and translate environmental stimuli into biologically meaningful signals. Sensations of touch, hearing, sight, taste, smell or pain are essential to the survival of all living organisms. The importance of sensory input for the existence of life thus justifies the effort made to understand its molecular origins. Sensing with Ion Channels focuses on ion channels as key molecules enabling biological systems to sense and process the physical and chemical stimuli that act upon cells in their living environment. Its aim is to serve as a reference to ion channel specialists and as a source of new information to non specialists who want to learn about the structural and functional diversity of ion channels and their role in sensory physiology.

  3. TRP channels: an overview

    DEFF Research Database (Denmark)

    Pedersen, Stine Falsig; Owsianik, Grzegorz; Nilius, Bernd

    2005-01-01

    to a plethora of data on the roles of TRPs in a variety of tissues and species, including mammals, insects, and yeast. The present review summarizes the most pertinent recent evidence regarding the structural and functional properties of TRP channels, focusing on the regulation and physiology of mammalian TRPs....

  4. Dual temperature dual pressure water-hydrogen chemical exchange for water detritiation

    Energy Technology Data Exchange (ETDEWEB)

    Sugiyama, Takahiko, E-mail: t-sugiyama@nucl.nagoya-u.ac.jp [Faculty of Engineering, Nagoya University, Fro-cho 1, Chikusa-ku, Nagoya 464-8603 (Japan); Takada, Akito; Morita, Youhei [Faculty of Engineering, Nagoya University, Fro-cho 1, Chikusa-ku, Nagoya 464-8603 (Japan); Kotoh, Kenji [Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka 819-0395 (Japan); Munakata, Kenzo [Faculty of Engineering and Resource Science, Akita University, Tegata-gakuen-machi 1-1, Akita 010-8502 (Japan); Taguchi, Akira [Hydrogen Isotope Research Center, University of Toyama, Gofuku 3190, Toyama 930-8555 (Japan); Kawano, Takao; Tanaka, Masahiro; Akata, Naofumi [National Institute for Fusion Science, Oroshi-cho 322-6, Toki, Gifu 509-5292 (Japan)

    2015-10-15

    Experimental and analytical studies on hydrogen-tritium isotope separation by a dual temperature dual pressure catalytic exchange (DTDP-CE) with liquid phase chemical exchange columns were carried out in order to apply it to a part of the water detritiation system for DEMO fuel cycle. A prototype DTDP-CE apparatus was successfully operated and it was confirmed that tritium was separated by the apparatus as significantly distinguishable. A calculation code was developed based on the channeling stage model. The values of separation factors and the effects of some operating parameters were well predicted by the separative analyses with the code.

  5. Investigating the performance of SiGe embedded dual source p-FinFET architecture

    Science.gov (United States)

    Sinha, Kunal; Gupta, Partha Sarathi; Chattopadhyay, Sanatan; Rahaman, Hafizur

    2016-10-01

    In this work, a modified Fin shaped Field Effect Transistor (FinFET) structure has been proposed with dual SiGe embedded extended source regions. Comparative simulation studies with SiGe embedded source/drain conventional single Fin channel and dual Fin channel FinFET structure having similar device footprint area shows almost 3× and 1.5× improvement of drive current respectively and lower threshold voltage in the proposed architecture. The dual extended SiGe source regions and presence of Si drain in the vertical direction of the channel generate bi-axial channel stress which improves the channel charge density, which results in improvement in drive current significantly. Also it has been observed from various simulation studies that the separated gate regions increase the inversion current density in the channel which also leads to improvement of the device performance.

  6. Dual targeting of peroxisomal proteins

    Directory of Open Access Journals (Sweden)

    Julia eAst

    2013-10-01

    Full Text Available Cellular compartmentalization into organelles serves to separate biological processes within the environment of a single cell. While some metabolic reactions are specific to a single organelle, others occur in more than one cellular compartment. Specific targeting of proteins to compartments inside of eukaryotic cells is mediated by defined sequence motifs. To achieve multiple targeting to different compartments cells use a variety of strategies. Here, we focus on mechanisms leading to dual targeting of peroxisomal proteins. In many instances, isoforms of peroxisomal proteins with distinct intracellular localization are encoded by separate genes. But also single genes can give rise to differentially localized proteins. Different isoforms can be generated by use of alternative transcriptional start sites, by differential splicing or ribosomal read-through of stop codons. In all these cases different peptide variants are produced, of which only one carries a peroxisomal targeting signal. Alternatively, peroxisomal proteins contain additional signals that compete for intracellular targeting. Dual localization of proteins residing in both the cytoplasm and in peroxisomes may also result from use of inefficient targeting signals. The recent observation that some bona fide cytoplasmic enzymes were also found in peroxisomes indicates that dual targeting of proteins to both the cytoplasm and the peroxisome might be more widespread. Although current knowledge of proteins exhibiting only partial peroxisomal targeting is far from being complete, we speculate that the metabolic capacity of peroxisomes might be larger than previously assumed.

  7. Multiplexed Millimeter Wave Communication with Dual Orbital Angular Momentum (OAM) Mode Antennas.

    Science.gov (United States)

    Hui, Xiaonan; Zheng, Shilie; Chen, Yiling; Hu, Yiping; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2015-05-19

    Communications using the orbital angular momentum (OAM) of radio waves have attracted much attention in recent years. In this paper, a novel millimeter-wave dual OAM mode antenna is cleverly designed, using which a 60 GHz wireless communication link with two separate OAM channels is experimentally demonstrated. The main body of the dual OAM antenna is a traveling-wave ring resonator using two feeding ports fed by a 90° hybrid coupler. A parabolic reflector is used to focus the beams. All the antenna components are fabricated by 3D printing technique and the electro-less copper plating surface treatment process. The performances of the antenna, such as S-parameters, near-fields, directivity, and isolation between the two OAM modes are measured. Experimental results show that this antenna can radiate two coaxially propagating OAM modes beams simultaneously. The multiplexing and de-multiplexing are easily realized in the antennas themselves. The two OAM mode channels have good isolation of more than 20 dB, thus ensuring the reliable transmission links at the same time.

  8. Competition in a Dual-channel Supply Chain with Add-value Services%基于增值服务的双渠道供应链竞争

    Institute of Scientific and Technical Information of China (English)

    罗美玲; 李刚; 孙林岩

    2011-01-01

    在物理产品基础上附加增值服务,为顾客提供差异化的增值服务,已经成为企业竞争市场的新模式.基于消费者效用理论,研究作为供应链主导方的制造商在通过传统渠道零售商分销其产品的同时,引入直销增值服务渠道对供应链各方的定价、市场份额和利润的影响,探讨制造商愿意引进增值服务渠道的条件.研究结果表明,引入增值服务渠道可以减轻价格双重边际效应,有效地扩大整个市场需求,但是零售商的利润总是受损的.制造商通过实施非负的转移支付可以实现双方利润的帕累托改进.%With the intensive competition in the marketplace,more and more firms begin to integrate their products with differentiated add-values services to compete customers. Competition based on service is becoming a new paradigm for supply chain management. Based on the consumer utility theory, the paper studied the manufacturer, who acted as the leader in Stackelberg game, introduced a direct add-value service channel to compete with the traditional retailer which only offers products to customers. The effect of the competition on the pricing, market share and profit allocation of the supply chain was analyzed. The condition that the manufacturer was willing to introduce the add-value services channel was derived. With the introducing of the add-valued service channel, the double marginalization in the supply chain is alleviated; the total market share is enlarged. However, the traditional retailer' s profit is reduced. And it can create a win-win situation if the manufacturer provides nonnegative transfer payment to the retailer.

  9. Research on Overbooking Strategy of“Hotel+OTA”Dual-Channel Supply Chain%“酒店+OTA”双渠道供应链超订策略研究

    Institute of Scientific and Technical Information of China (English)

    叶飞; 陆木蕊; 廖鹏

    2015-01-01

    In order to solve overbooking and allocation problem with demand uncertainty when hotel collaborates with Online Travel Agency , we formulate a mathematical model based on the Agency Model .The optimal over-booking and allocation policies are derived .A numerical example is further given to study the effects of commis-sion rate and demand uncertainty on the optimal decisions .The results show that the hotel manager will apply du-al-channel and utilize overbooking policy when the commission rate and demand uncertainty are low .However , when the commission rate and demand uncertainty are high enough , the hotel manager will apply single-channel and do not utilize overbooking policy .We also find that the hotel manager will reduce the room allocation to OTA when the demand of offline channel becomes more uncertain or the commission rate increases .%为解决市场需求不确定环境下,酒店和在线旅行网站( Online Travel Agency ,OTA)合作时的能力超订量与在线房间预留量的决策问题,建立了基于佣金合作模式的数学模型,给出了实现酒店整体期望收益最大化的在线房间预留量与能力超订量。借助数值分析,进一步研究了佣金率与需求不确定性对最优决策的影响。结果表明,当佣金率与门店需求不确定性较小时,酒店采取双渠道策略并且实施超订;当佣金率与门店需求不确定性很大时,酒店采取门店单渠道策略但不实施超订。另外,在线房间预留量随着佣金率、门店需求不确定性的增大而减小。

  10. The Dual Career Family.

    Science.gov (United States)

    Gurtin, Lee

    1980-01-01

    The dual career couple is forced to make a series of choices and compromises that impact the realms of marriage and career. The dilemmas that confront dual career marriages can be overcome only by compromise, accommodation, and mutual understanding on the part of the individuals involved. A revamping of human resources and recruitment programs is…

  11. Self-Dual Gravity

    CERN Document Server

    Krasnov, Kirill

    2016-01-01

    Self-dual gravity is a diffeomorphism invariant theory in four dimensions that describes two propagating polarisations of the graviton and has a negative mass dimension coupling constant. Nevertheless, this theory is not only renormalisable but quantum finite, as we explain. We also collect various facts about self-dual gravity that are scattered across the literature.

  12. Dual Youla parameterization

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik

    2003-01-01

    A different aspect of using the parameterisation of all systems stabilised by a given controller, i.e. the dual Youla parameterisation, is considered. The relation between system change and the dual Youla parameter is derived in explicit form. A number of standard uncertain model descriptions are...

  13. Optical dual self functions

    Institute of Scientific and Technical Information of China (English)

    华建文; 刘立人; 王宁

    1997-01-01

    A recipe to construct the exact dual self-Fourier-Fresnel-transform functions is shown, where the Dirac comb function and transformable even periodic function are used. The mathematical proof and examples are given Then this kind of self-transform function is extended to the feasible optical dual self-transform functions.

  14. Dual doubled geometry

    NARCIS (Netherlands)

    Bergshoeff, Eric A.; Riccioni, Fabio; Alvarez-Gaumé, L.

    2011-01-01

    We probe doubled geometry with dual fundamental branes. i.e. solitons. Restricting ourselves first to solitonic branes with more than two transverse directions we find that the doubled geometry requires an effective wrapping rule for the solitonic branes which is dual to the wrapping rule for fundam

  15. Modeling of Ad-hoc and Infrastructure Dual Mode Mobile Networks

    Institute of Scientific and Technical Information of China (English)

    Yi-Hung Chen; Hui-Nien Hung; Yi-Bing Lin; Nan-Fu Peng

    2005-01-01

    This paper investigates a mobile telecommunications system that supports both ad hoc and infrastructure mode operations. Based on analytic and simulation models, our study investigates how base station (BS) and ad hoc channel capacity, and the mobility and locality of mobile stations affect the performance of a dual mode system. We show that a dual mode system can significantly outperform a single mode (infrastructure) system when the degree of locality is high. Furthermore, a dual mode system can support much faster mobile users with less BS channels in comparison to an infrastructure mode system. Our study quantitatively identifies the threshold value for the number of ad hoc channels such that beyond this threshold, increasing ad hoc channel capacity will not improve the performance of a dual mode system.

  16. Dual Focus upon Industrial Restructuring and Market Access Management

    Institute of Scientific and Technical Information of China (English)

    张立群

    2007-01-01

    The Central Economic Working Conference of the CPC sets out an important mission for China’s economic development in 2007:"tak- ing energy conservation and protection of the ecological environment as the starting point,actively promote optimization and upgrade of the industrial structure".

  17. Universally applicable three-dimensional hydrodynamic microfluidic flow focusing

    OpenAIRE

    Chiu, Yu-Jui; Cho, Sung Hwan; Mei, Zhe; Lien, Victor; Wu, Tsung-Feng; Lo, Yu-Hwa

    2013-01-01

    We have demonstrated a microfluidic device that can not only achieve three-dimensional flow focusing but also confine particles to the center stream along the channel. The device has a sample channel of smaller height and two sheath flow channels of greater height, merged into the downstream main channel where 3D focusing effects occur. We have demonstrated that both beads and cells in our device display significantly lower CVs in velocity and position distributions as well as reduced probabi...

  18. Research on Dual Control

    Institute of Scientific and Technical Information of China (English)

    Duan Li; Fucai Qian; Peilin Fu

    2005-01-01

    This paper summarizes recent progress by the authors in developing two solution frameworks for dual control. The first solution framework considers a class of dual control problems where there exists a parameter uncertainty in the observation equation of the LQG problem. An analytical active dual control law is derived by a variance minimization approach. The issue of how to determine an optimal degree of active learning is then addressed, thus achieving an optimality for this class of dual control problems. The second solution framework considers a general class of discrete-time LQG problems with unknown parameters in both state and observation equations. The best possible (partial) closed-loop feedback control law is derived by exploring the future nominal posterior probabilities, thus taking into account the effect of future learning when constructing the optimal nominal dual control.

  19. Dual pathways of calcium entry in spike and plateau phases of luteinizing hormone release from chicken pituitary cells: sequential activation of receptor-operated and voltage-sensitive calcium channels by gonadotropin-releasing hormone

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, J.S.; Wakefield, I.K.; King, J.A.; Mulligan, G.P.; Millar, R.P.

    1988-04-01

    It has previously been shown that, in pituitary gonadotrope cells, the initial rise in cytosolic Ca2+ induced by GnRH is due to a Ca2+ mobilization from intracellular stores. This raises the possibility that the initial transient spike phase of LH release might be fully or partially independent of extracellular Ca2+. We have therefore characterized the extracellular Ca2+ requirements, and the sensitivity to Ca2+ channel blockers, of the spike and plateau phases of secretion separately. In the absence of extracellular Ca2+ the spike and plateau phases were inhibited by 65 +/- 4% and 106 +/- 3%, respectively. Both phases exhibited a similar dependence on concentration of extracellular Ca2+. However, voltage-sensitive Ca2+ channel blockers D600 and nifedipine had a negligible effect on the spike phase, while inhibiting the plateau phase by approximately 50%. In contrast, ruthenium red, Gd3+ ions, and Co2+ ions inhibited both spike and plateau phases to a similar extent as removal of extracellular Ca2+. A fraction (35 +/- 4%) of spike phase release was resistant to removal of extracellular Ca2+. This fraction was abolished after calcium depletion of the cells by preincubation with EGTA in the presence of calcium ionophore A23187, indicating that it depends on intracellular Ca2+ stores. Neither absence of extracellular Ca2+, nor the presence of ruthenium red or Gd3+ prevented mobilization of 45Ca2+ from intracellular stores by GnRH. We conclude that mobilization of intracellular stored Ca2+ is insufficient by itself to account for full spike phase LH release.

  20. Chloride channels in stroke

    Institute of Scientific and Technical Information of China (English)

    Ya-ping ZHANG; Hao ZHANG; Dayue Darrel DUAN

    2013-01-01

    Vascular remodeling of cerebral arterioles,including proliferation,migration,and apoptosis of vascular smooth muscle cells (VSMCs),is the major cause of changes in the cross-sectional area and diameter of the arteries and sudden interruption of blood flow or hemorrhage in the brain,ie,stroke.Accumulating evidence strongly supports an important role for chloride (Clˉ) channels in vascular remodeling and stroke.At least three Clˉ channel genes are expressed in VSMCs:1) the TMEM16A (or Ano1),which may encode the calcium-activated Clˉ channels (CACCs); 2) the CLC-3 Clˉ channel and Clˉ/H+ antiporter,which is closely related to the volume-regulated Clˉ channels (VRCCs); and 3) the cystic fibrosis transmembrane conductance regulator (CFTR),which encodes the PKA-and PKC-activated Clˉ channels.Activation of the CACCs by agonist-induced increase in intracellular Ca2+ causes membrane depolarization,vasoconstriction,and inhibition of VSMC proliferation.Activation of VRCCs by cell volume increase or membrane stretch promotes the production of reactive oxygen species,induces proliferation and inhibits apoptosis of VSMCs.Activation of CFTR inhibits oxidative stress and may prevent the development of hypertension.In addition,Clˉ current mediated by gammaaminobutyric acid (GABA) receptor has also been implicated a role in ischemic neuron death.This review focuses on the functional roles of Clˉ channels in the development of stroke and provides a perspective on the future directions for research and the potential to develop Clˉ channels as new targets for the prevention and treatment of stroke.

  1. White Light Focusing Mirror

    Science.gov (United States)

    Johnson, Eric; Lyndaker, Aaron; Deyhim, Alex; Sullivan, Michael; Chance, Mark; Abel, Don; Toomey, John; Hulbert, Steven

    2007-01-01

    The NSLS X28C white-light beamline is being outfitted with a focusing mirror in order to increase, as well as control, the x-ray intensity at the sample position. The new mirror is a 50 mm × 100 mm × 1100 mm single crystal silicon cylindrical 43.1mm radius substrate bendable to a toroid from infinite to 1200 m radius. The unique feature of this mirror system is the dual use of Indalloy 51 as both a mechanism for heat transfer and a buoyant support to negate the effects of gravity. The benefit of the liquid metal support is the ability to correct for minor slope errors that take the form of a parabola. A bobber mechanism is employed to displace the fluid under the mirror +/- 1.5 mm. This allows RMS slope error correction on the order of 2 urad. The unique mounting of the mirror ensures the contributions to slope error from errant mechanical stresses due to machining tolerances are virtually non-existent. After correction, the surface figure error (measured minus ideal) is <= 0.5 urad rms.

  2. Researches toward potassium channels on tumor progressions.

    Science.gov (United States)

    Shen, Zheng; Yang, Qian; You, Qidong

    2009-01-01

    As trans-membrane proteins located in cytoplasm and organelle membrane, potassium (K(+)) channels are generally divided into four super-families: voltage-gated K(+) channels (K(v)), Ca(2+)-activated K(+) channels (K(Ca)), inwardly rectifying K(+) channels (K(ir)) and two-pore domain K(+) channels (K(2P)). Since dysfunctions of K(+) channels would induce many diseases, various studies toward their functions in physiologic and pathologic process have been extensively launched. This review focuses on the recent advances of K(+) channels in tumor progression, including the brief introduction of K(+) channels, the role of K(+) channels in tumor cells, the possible mechanism of action at cellular level, and the possible application of K(+) channel modulators in cancer chemotherapy.

  3. Dual differential polarimetry. A technique to recover polarimetric information from dual polarization observations

    CERN Document Server

    Marti-Vidal, I; Muller, S

    2016-01-01

    Current mm/submm interferometers, like the Atacama Large mm/submm Array (ALMA), use receivers that register the sky signal in a linear polarization basis. In the case of observations performed in full-polarization mode (where the cross-correlations are computed among all the polarization channels) it is possible to reconstruct the full-polarization brightness distribution of the observed sources, as long as a proper calibration of delay offsets and leakage among polarization channels can be performed. Observations of calibrators, preferably with some linear polarization, with a good parallactic angle coverage are usually needed for such a calibration. In principle, dual-polarization observations only allow us to recover the Stokes $I$ intensity distribution of the sources, regardless of the parallactic angle coverage of the observations. In this paper, we present a novel technique of dual differential polarimetry that makes it possible to obtain information related to the full-polarization brightness distribu...

  4. Mechanosensitive Channels

    Science.gov (United States)

    Martinac, Boris

    Living cells are exposed to a variety of mechanical stimuli acting throughout the biosphere. The range of the stimuli extends from thermal molecular agitation to potentially destructive cell swelling caused by osmotic pressure gradients. Cellular membranes present a major target for these stimuli. To detect mechanical forces acting upon them cell membranes are equipped with mechanosensitive (MS) ion channels. Functioning as molecular mechanoelectrical transducers of mechanical forces into electrical and/or chemical intracellular signals these channels play a critical role in the physiology of mechanotransduction. Studies of prokaryotic MS channels and recent work on MS channels of eukaryotes have significantly increased our understanding of their gating mechanism, physiological functions, and evolutionary origins as well as their role in the pathology of disease.

  5. Theory of dual probes on graphene structures

    DEFF Research Database (Denmark)

    Settnes, Mikkel

    and their interplay gives rise to resonances in the dual probe conductance and can be associated with vortex-like current patterns either guiding or suppressing the current. We further address the effect of strain in graphene when subjected to mechanical deformations giving rise to so-called pseudomagnetic fields...... size of the dots, sublattice polarization and Landau quantization. Additionally, we use the dual probe conductance to demonstrate the current guiding ability of the pseudomagnetic fields leading to preferential scattering directions responsible for the observed pseudomagnetic focusing and anti...

  6. Dual waveband compact catadioptric imaging spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Chrisp, Michael P.

    2012-12-25

    A catadioptric dual waveband imaging spectrometer that covers the visible through short-wave infrared, and the midwave infrared spectral regions, dispersing the visible through shortwave infrared with a zinc selenide grating and midwave infrared with a sapphire prism. The grating and prism are at the cold stop position, enabling the pupil to be split between them. The spectra for both wavebands are focused onto the relevant sections of a single dual waveband detector. Spatial keystone distortion is controlled to less than one tenth of a pixel over the full wavelength range, facilitating the matching of the spectra in the midwave infrared with the shorter wavelength region.

  7. Pricing and coordination strategy of closed-loop supply chain under dual channel recovery%双渠道回收下闭环供应链的定价与协调策略

    Institute of Scientific and Technical Information of China (English)

    张成堂; 杨善林

    2013-01-01

    针对新产品与再制造产品存在销售价格差异以及废旧产品有两条回收渠道的情形,研究了闭环供应链系统的回收与销售定价策略.研究表明,Stackelberg博弈定价会造成系统效率的损失,而联合决策定价可以回收到更多废旧产品,产品售价最低,系统利润达到最大.为此,以联合决策下的均衡结果为基准,通过设计收入一费用共享契约和两部收费制相结合的协调定价机制,确定合理的分享系数范围和资格代理费,能够实现闭环供应链系统的完美协调.通过算例分析验证了渠道冲突、成本参数等对供应链定价的影响和有关结论的成立.%Aiming at the price difference between new and remanufactured products as well as the two recovery channels for waste products,pricing and coordination strategy of closed-loop supply chain were studied.The results revealed a loss of system efficiency caused by Stackelberg game pricing along with more recovered waste products,lowest product price and maximum profits deriving from the use of joint decision-making pricing.Therefore,on basis of equilibrium result under joint decision-making,through conception of a coordinated pricing mechanism that incorporates revenue-and-expense sharing contract and two-part tariff system,a reasonable range of the sharing coefficient and agency fees for qualifications which would enable the perfect coordination of closed-loop supply chain was identified.Further numerical examples were used to verify the impact of channel conflicts and cost parameters on supply chain pricing and the tenability of relevant conclusions.

  8. IMAGING AND MTI PROCESSING BASED ON DUAL-FREQUENCIES DUAL-APERTURES SPACEBORNE SAR

    Institute of Scientific and Technical Information of China (English)

    Yin Jianfeng; Li Daojing; Wu Yirong

    2009-01-01

    Based on dual-frequencies dual-apertures spaceborne SAR (Synthetic Aperture Radar), a new SAR system with four receiving channels and two operation modes is presented in this paper. SAR imaging and Moving Target Indication (MTI) are studied in this system. High resolution imaging with wide swath is implemented by the Mode I, and MTI is completed by the Mode II. High azimuth resolution is achieved by the Displaced Phase Center (DPC) multibeam technique. And the Coherent Accumulation (CA) method, which combines dual channels data of different carrier frequency, is used to enhance the range resolution. For the data of different carrier frequency, the two aperture interferometric processing is executed to implement clutter cancellation, respectively. And the couple of clutter suppressed data are employed to implement Dual Carrier Frequency Conjugate Processing (DCFCP), then both slow and fast moving targets detection can be completed, followed by moving target imaging. The simulation results show the validity of the signal processing method of this new SAR system.

  9. A WATER-SOLUBLE DUAL-CHANNEL FLUORESCENCE-ENHANCED BIOSENSOR FOR HEPARIN BASED ON A CATIONIC CONJUGATED POLYELECTROLYTE CONTAINING TETRAPHENYLETHENE AND 2,1,3-BENZOTHIADIAZOLE%荧光增强型共轭聚电解质的合成及对肝素的双通道检测

    Institute of Scientific and Technical Information of China (English)

    吴燕梅; 石建兵; 佟斌; 支俊格; 董宇平

    2012-01-01

    A conjugated polymer ( P0) containing tetraphenylethene ( TPE) group and benzothiadiazole (BT) group has been designed and synthesized by Suzuki coupling reaction of 1,2-di[4-(6-bromohexyloxy) phenyl]-l ,2-di(4-bromophenyl)ethene (Ml) , 1,2-di[4-(6-bromohexyloxy) phenyl]-1 ,2-di(4-(4,4,5,5-tetramethyl-1 ,3, 2-dioxaborolan-2-yl) phenyl) ethylene ( M2 ) and 4, 7-dibromo-2 , 1 , 3-benzothiadiazole (M3). The ratio of TPE unit to BT unit at 0. 803: 0. 197 was determined by 1H-NMR spectrum. A water-soluble cationic conjugated polyelectrolyte (P1) is obtained by quaternization P0 with trimethylamine,which is completely soluble in water and insoluble in common organic solvents such as THF and acetone. When P1 is aggregated by adding a poor solvent such as THF into P1 aqueous solution, the fluorescence intensity and color of P1 change drastically. The intensity increases up to seven times and the maximum emission peak is red-shifted up to 30 nm. The color is changing from khaki ( no aggregation) to orange ( aggregation) under ultraviolet irradiation. Therefore, dual-channel fluorescence response as the unique properties of P1 was applied to detect heparin, a highly sulfated glycosaminoglycan with the highest negative charge density among the known biological molecules. The fluorescence intensity gradually increased upon addition of heparin into P1 aqueous solution with a linear response to concentration of heparin, and the correlation coefficient was up to 0. 9999. In addition, a linear red shift of the maximum emission peak was observed as the concentration of heparin increased with a correlation coefficient up to 0. 9998. These results indicate that P1 is a potential material for developing dual-channel fluorescence probe for heparin quantification. The UV spectra of P1/ heparin complexing titration don' t show any change. This indicates that there is no inter-chains or intra-chains π-π stacking of P1. DLS result indicates some aggregates can be formed through

  10. Dual coil ignition system

    Energy Technology Data Exchange (ETDEWEB)

    Huberts, Garlan J.; Qu, Qiuping; Czekala, Michael Damian

    2017-03-28

    A dual coil ignition system is provided. The dual coil ignition system includes a first inductive ignition coil including a first primary winding and a first secondary winding, and a second inductive ignition coil including a second primary winding and a second secondary winding, the second secondary winding connected in series to the first secondary winding. The dual coil ignition system further includes a diode network including a first diode and a second diode connected between the first secondary winding and the second secondary winding.

  11. Dual Adaptive Turbo Coded Modulation for Integrated Multimedia Service Transmission

    Institute of Scientific and Technical Information of China (English)

    左健存; 宋文涛; 罗汉文; 徐友云

    2004-01-01

    This paper proposes a cross-layer dual adaptive coded modulation architecture using turbo codes for mobile multimedia communication, which adapts to both the varying channel characteristics and the QoS of various multimedia services simultaneously to increase the average system throughput substantially. A pragmatic channeladaptive turbo coded modulation scheme, which comes within 2.5 Db of the Shannon limit, is optimally designed,and then a QoS-adaptive scheme is superimposed to build the dual adaptive architecture. Simulation results show that the novel dual adaption reduces the gap from the fading channel capacity to 2 Db when assuming different services occur in equal probability and the service duration follows exponential distribution.

  12. What is the dual of a dipole?

    CERN Document Server

    Alday, L F; Messamah, I; Alday, Luis F.; Boer, Jan de; Messamah, Ilies

    2006-01-01

    We study gravitational solutions that admit a dual CFT description and carry non zero dipole charge. We focus on the black ring solution in AdS_3 x S^3 and extract from it the one-point functions of all CFT operators dual to scalar excitations of the six-dimensional metric. In the case of small black rings, characterized by the level N, angular momentum J and dipole charge q_3, we show how the large N and J dependence of the one-point functions can be reproduced, under certain assumptions, directly from a suitable ensemble in the dual CFT. Finally we present a simple toy model that describes the thermodynamics of the small black ring for arbitrary values of the dipole charge.

  13. What is the dual of a dipole?

    Energy Technology Data Exchange (ETDEWEB)

    Alday, Luis F. [Institute for Theoretical Physics and Spinoza Institute, Utrecht University, 3508 TD Utrecht (Netherlands)]. E-mail: l.f.alday@phys.uu.nl; Boer, Jan de [Instituut voor Theoretische Fysica, Valckenierstraat 65, 1018 XE Amsterdam (Netherlands)]. E-mail: jdeboer@science.uva.nl; Messamah, Ilies [Instituut voor Theoretische Fysica, Valckenierstraat 65, 1018 XE Amsterdam (Netherlands)]. E-mail: imessama@science.uva.nl

    2006-07-03

    We study gravitational solutions that admit a dual CFT description and carry non-zero dipole charge. We focus on the black ring solution in AdS{sub 3}xS{sup 3} and extract from it the one-point functions of all CFT operators dual to scalar excitations of the six-dimensional metric. In the case of small black rings, characterized by the level N, angular momentum J and dipole charge q{sub 3}, we show how the large N and J dependence of the one-point functions can be reproduced, under certain assumptions, directly from a suitable ensemble in the dual CFT. Finally we present a simple toy model that describes the thermodynamics of the small black ring for arbitrary values of the dipole charge.

  14. Experimental Array for Generating Dual Circularly-Polarized Dual-Mode OAM Radio Beams

    Science.gov (United States)

    Bai, Xu-Dong; Liang, Xian-Ling; Sun, Yun-Tao; Hu, Peng-Cheng; Yao, Yu; Wang, Kun; Geng, Jun-Ping; Jin, Rong-Hong

    2017-01-01

    Recently, vortex beam carrying orbital angular momentum (OAM) for radio communications has attracted much attention for its potential of transmitting multiple signals simultaneously at the same frequency, which can be used to increase the channel capacity. However, most of the methods for getting multi-mode OAM radio beams are of complicated structure and very high cost. This paper provides an effective solution of generating dual circularly-polarized (CP) dual-mode OAM beams. The antenna consists of four dual-CP elements which are sequentially rotated 90 degrees in the clockwise direction. Different from all previous published research relating to OAM generation by phased arrays, the four elements are fed with the same phase for both left-hand circular polarization (LHCP) and right-hand circular polarization (RHCP). The dual-mode operation for OAM is achieved through the opposite phase differences generated for LHCP and RHCP, when the dual-CP elements are sequentially rotated in the clockwise direction. The measured results coincide well with the simulated ones, which verified the effectiveness of the proposed design.

  15. Radiation Reaction in a Bent Focusing System

    Science.gov (United States)

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.

    1996-05-01

    We have shown that in a straight, continuous focusing channel the radiation reaction is different from that in a bending magnet. Quantum excitation to the transverse action is absent in this focusing system, and the radiation damping is faster in the transverse direction than in the longitudinal one. In this talk we study the effect of radiation in a combined-function system, where both focusing and bending fields are present. In one case where the bending dominates over the focusing, we recover the result of standard synchrotron radiation damping in storage rings. In the other case where the focusing dominates over the bending, we find that the lack of quantum excitation and the asymmetric damping found in a straight focusing channel still hold. In addition, the possibility of designing a focusing-dominated damping ring to demonstrate and apply this effect is discussed.

  16. Volume phase holographic gratings for the Subaru Prime Focus Spectrograph: performance measurements of the prototype grating set

    CERN Document Server

    Barkhouser, Robert; Gunn, James E

    2014-01-01

    The Prime Focus Spectrograph (PFS) is a major instrument under development for the 8.2 m Subaru telescope. Four identical spectrograph modules are located in a room above one Nasmyth focus. A 55~m fiber optic cable feeds light to the spectrographs from a robotic positioner at the prime focus, behind the wide-field corrector developed for Hyper Suprime-Cam. The positioner contains 2400 fibers and covers a 1.3~degree hexagonal field of view. The spectrograph optical design consists of a Schmidt collimator, two dichroic beamsplitters to split the light into three channels, and for each channel a volume phase holographic (VPH) grating and a dual-corrector, modified Schmidt reimaging camera. This design provides a 275~mm collimated beam diameter, wide simultaneous wavelength coverage from 380~nm to 1.26~\\textmu m, and good imaging performance at the fast f/1.05 focal ratio required from the cameras to avoid oversampling the fibers. The three channels are designated as the blue, red, and near-infrared (NIR), and co...

  17. Demonstration and evaluation of dual-fuel technology; Demonstration och utvaerdering av dual-fuel-tekniken

    Energy Technology Data Exchange (ETDEWEB)

    Staalhammar, Per; Erlandsson, Lennart; Willner, Kristina (AVL MTC Motortestcenter AB (Sweden)); Johannesson, Staffan (Ecoplan AB (Sweden))

    2011-06-15

    There is an increased interest for Dual Fuel (methane-Diesel) applications in Sweden since this technology is seen as one of the more interesting options for a fast and cost effective introduction of biomethane as fuel for HD engines. The Dual Fuel technology has been used for many years, mainly for stationary purpose (generators, pumps and ships) while the Spark Ignited (SI) 'Otto' technology has been used for trucks and busses. One obstacle for introducing Dual Fuel technology for busses and trucks is the EU legislation that don't allow for HD on road certification of Dual Fuel applications. Challenges with the Dual Fuel technology is to develop cost effective applications that is capable of reaching low emissions (especially CH{sub 4} and NO{sub x}) in combination with high Diesel replacement in the test cycles used for on road applications. AVL MTC Motortestcenter AB (hereinafter called AVL) has on commission by SGC (Swedish Gas technical Centre) carried out this project with the objectives to analyze the Dual Fuel (Diesel-methane) technology with focus on emissions, fuel consumption and technical challenges. One important part of this project was to carry out emission tests on selected Dual Fuel applications in Sweden and to compile experiences from existing Dual Fuel technology. This report also summarizes other commonly used technologies for methane engines and compares the Dual Fuel with conventional Diesel and Otto technologies. The major challenges with Dual Fuel applications for on road vehicles will be to develop robust and cost effective solutions that meet the emission legislations (with aged catalysts) and to increase the Diesel replacement to achieve reasonable reduction of green house gases (GHG). This is especially important when biomethane is available as fuel but not Bio-Diesel. It will probably be possible to reach EURO V emission limits with advanced Dual Fuel systems but none of the tested systems reached EURO V emission levels

  18. 非对称双栅结构 a-Si:H 薄膜晶体管沟道电势统一模型%A Unified Channel Potential Model for Asymetrical Dual Gate a-Si:H Thin Film Transistors

    Institute of Scientific and Technical Information of China (English)

    秦剑; 姚若河

    2016-01-01

    针对非对称双栅结构的非晶硅薄膜晶体管,根据高斯定理建立了表面势与背电势随栅压变化的隐含关联方程组,通过求解一维泊松方程推导了前、背栅压独立偏置条件下统一的沟道电势模型。该模型所需参数可由实验直接提取,数值拟合量少,在特定条件下可简化为对称双栅模型。在此基础上,文中利用数学变换及Lambert W函数提出了表面势与栅压隐含方程的近似求解方法。数值模拟结果显示,该方法具有良好的数值收敛特性,可直接用于器件仿真软件的初值设定,有效提升了模型自洽解的运算效率。%On the basis of the Gauss’s law, two sets of implicit potential equations describing the changes of surface potential and back one with gate voltage are established for asymmetrical dual gate a-Si:TFT thin film transistors. Then, a unified channel potential model with two independent gates is constructed by solving 1-D Poisson equa-tions.This model can be simplified to a symmetric dual gate model under given conditions.In addition, most of relevant parameters can be physically extracted from real experimental data and only few fitting parameters are in-volved.On this basis, a novel scheme for the approximation of surface potentials is proposed by means of mathe-matical transformation and by using the Lambert W function.Numerical results show that the proposed scheme is of better convergence and the approximation of those potentials can be directly used to set the initial values of simulation tools, which effectively improves the computation efficiency of self-consistent solutions to the constructed model.

  19. Dual Language Learning / Duale Spracherlernung. Learning German through English

    Directory of Open Access Journals (Sweden)

    Fee-Alexandra Haase

    2014-07-01

    Full Text Available In this article we examine the impact of English in the learning process of the German language exemplified with the example of the second language acquisition process of the German language in the programs of German in the Department of Foreign Languages of the University of Nizwa in Oman. This study focuses on the distinct features of students in Oman learning German as a second language in an institution of higher education in Oman. The contrastive rhetoric of a German – Oman Arabic language contact situation is challenging and a unique field of research, which allows us to study the process of foreign language learning (L2 and the implementation of the culture of the native language L1 (Arabic. The reflection of the L1 culture, the Arab Oman culture, in the language learning process of the L2 language (German will be described, analyzed and discussed aiming the improvement of the L2 learning process. This article investigates into the process of learning German in an Arabic country of native speakers of Arabic from the perspective of the cultural differences of both cultures in terms of their linguistic prepositions.Received: 17/09/2013 / Accepted: 23/11/2013How to reference this articleHaase, F-A. (2014. Dual Language Learning / Duale Spracherlernung. Learning German through English. Foro de Educación, 12(17, pp. 197-216. doi: http://dx.doi.org/10.14516/fde.2014.012.017.010

  20. Brands & Channels

    Institute of Scientific and Technical Information of China (English)

    Alice Yang

    2009-01-01

    @@ "Brands" and "Channels" are the two most important things in Ku-Hai Chen's eyes when doing business with Main-land China. Ku-Hai Chen, Executive Director of the International Trade Institute of Taiwan External Trade Development Council (TAITRA), flies frequently between Chinese Taipei and Mainland China, and was in Beijing earlier this month for his seminar.

  1. Positron Channeling

    CERN Document Server

    Badikyan, Karen

    2016-01-01

    The possibility of channeling the low-energy relativistic positrons around separate crystallographic axes with coaxial symmetry of negative ions in some types of crystals is shown. The process of annihilation of positrons with electrons of medium was studied in detail.

  2. Cerebral artery evaluation of dual energy CT angiography with dual source CT

    Institute of Scientific and Technical Information of China (English)

    MA Rui; LIU Cheng; DENG Kai; SONG Shao-juan; WANG Dao-ping; HUANG Ling

    2010-01-01

    Background Conventional computed tomography angiography (CTA) is time consuming, user-dependent and has poor image quality in skull base region. This study assessed the feasibility of a new method, dual energy CTA for depicting the cerebral artery.Methods Phantom scan was done with head CTA sequences on dual source CT and 64 spiral CT for radiation dose calculation. Dual energy CTA was done with dual source CT on 36 patients who were suspected of having cerebral vascular disease. Three series axial images in 0.75 mm thick, 0.4 mm increment were acquired, which were named with 80 kV, 140 kV and merged images; 80 kV and 140 kV images were transferred into dual energy software, and maximum intensity projection (MIP) image was generated quickly by dual energy bone remove (DEBR group); merged images were transferred into In Space software to acquire MIP image through manual conventional bone remove (CoBR group). Post processing time and reading time were compared. Image qualities of the two groups were compared, mainly focusing on skull base segments of internal carotid artery and bone subtraction. ANOVA and SNK tests were applied for radiation dose comparison. Student's t test and Wilcoxon rank sum test were applied for assessing differences between data for significance. Cohen's kappa was used for interobserver agreement. Results Radiation dose of phantom scan showed dual energy CTA was between digital bone subtraction and conventional CTA. The post processing time and reading time were much shorter in DEBR than CoBR, and image quality in skull base was much higher in DEBR than CoBR (P0.5). Interobserver agreement for all vessel segments was excellent (kappa=0.97). Conclusions Dual energy CTA is a reliable, new modality for depicting cerebral artery, overcoming the limitation of conventional CTA in the skull base region. It can save much time in post processing and reading than conventional CTA.

  3. DUAL Gamma-Ray Mission

    CERN Document Server

    Boggs, S; von Ballmoos, P; Takahashi, T; Gehrels, N; Tueller, J; Baring, M; Beacom, J; Diehl, R; Greiner, J; Grove, E; Hartmann, D; Hernanz, M; Jean, P; Johnson, N; Kanbach, G; Kippen, M; Knödlseder, J; Leising, M; Madejski, G; McConnell, M; Milne, P; Motohide, K; Nakazawa, K; Oberlack, U; Phlips, B; Ryan, J; Skinner, G; Starrfield, S; Tajima, H; Wulf, E; Zoglauer, A; Zych, A

    2010-01-01

    Gamma-ray astronomy presents an extraordinary scientific potential for the study of the most powerful sources and the most violent events in the Universe. In order to take full advantage of this potential, the next generation of instrumentation for this domain will have to achieve an improvement in sensitivity over present technologies of at least an order of magnitude. The DUAL mission concept takes up this challenge in two complementary ways: a very long observation of the entire sky, combined with a large collection area for simultaneous observations of Type Ia SNe. While the Wide-Field Compton Telescope (WCT) accumulates data from the full gamma-ray sky (0.1-10 MeV) over the entire mission lifetime, the Laue-Lens Telescope (LLT) focuses on 56Co emission from SNe Ia (0.8-0.9 MeV), collecting gamma-rays from its large area crystal lens onto the WCT. Two separated spacecraft flying in formation will maintain the DUAL payloads at the lens' focal distance.

  4. TRP Channels in Human Prostate

    Directory of Open Access Journals (Sweden)

    Carl Van Haute

    2010-01-01

    Full Text Available This review gives an overview of morphological and functional characteristics in the human prostate. It will focus on the current knowledge about transient receptor potential (TRP channels expressed in the human prostate, and their putative role in normal physiology and prostate carcinogenesis. Controversial data regarding the expression pattern and the potential impact of TRP channels in prostate function, and their involvement in prostate cancer and other prostate diseases, will be discussed.

  5. Dual energy with dual source CT and kVp switching with single source CT: a comparison of dual energy performance

    Science.gov (United States)

    Grasruck, M.; Kappler, S.; Reinwand, M.; Stierstorfer, K.

    2009-02-01

    Stimulated by the introduction of clinical dual source CT, the interest in dual energy methods has been increasing in the past years. Whereas the potential of material decomposition by dual energy methods is known since the early 1980ies, the realization of dual energy methods is a wide field of today's research. Energy separation can be achieved with energy selective detectors or by varying X-ray source spectra. This paper focuses on dual energy techniques with varying X-ray spectra. These can be provided by dual source CT devices, operated with different kVp settings on each tube. Excellent spectral separation is the key property for use in clinical routine. The drawback of higher cost for two tubes and two detectors leads to an alternative realization, where a single source CT yields different spectra by fast kVp switching from reading to reading. This provides access to dual-energy methods in single source CT. However, this technique comes with some intrinsic limitations. The maximum X-ray flux is reduced in comparison to the dual source system. The kVp rise and fall time between each reading reduces the spectral separation. In comparison to dual source CT, for a constant number of projections per energy spectrum the temporal resolution is reduced; a reasonable trade of between reduced numbers of projection and limited temporal resolution has to be found. The overall dual energy performance is the guiding line for our investigations. We present simulations and measurements which benchmark both solutions in terms of spectral behavior, especially of spectral separation.

  6. Control of beam halo-chaos using real Morlet wavelet function in a periodic-focusing channel%周期聚焦磁场中束晕-混沌的实Morlet小波函数控制

    Institute of Scientific and Technical Information of China (English)

    余海军; 白龙; 翁甲强; 罗晓曙; 方锦清

    2008-01-01

    基于束晕-混沌的非线性控制策略,对周期性聚焦磁场中初始分布满足K-V分布的粒子束进行模拟研究,提出了控制其束晕-混沌的实Morlet小波函数控制器,并给出具体的实施方案.数值模拟研究表明,在适当的参数条件下,运用这种方法不仅可以消除束晕及其再生现象,达到对束晕-混沌的有效控制,而且可以控制束流到均匀分布.%The Kapchinsky-Vladimirsky (K-V) beam through an axisymmetric periodic-focusing magnetic field is studied using the particle-core model. The beam halo-chaos is found, and a real Morlet wavelet function controller is proposed based on the mechanism of halo formation and the strategy of controlling halo-chaos. The method is applied to the multi-particle simulation to control the halo. The numerical results show that the halo-chaos and its regeneration can be eliminated effectively by using the real Morlet wavelet function control method. At the same time, the radial particle density is uniform at the center of the beam as long as the control method and appropriate parameter are chosen.

  7. Channel Power in Multi-Channel Environments

    NARCIS (Netherlands)

    M.G. Dekimpe (Marnik); B. Skiera (Bernd)

    2004-01-01

    textabstractIn the literature, little attention has been paid to instances where companies add an Internet channel to their direct channel portfolio. However, actively managing multiple sales channels requires knowing the customers’ channel preferences and the resulting channel power. Two key compon

  8. Ion channels in neuronal survival

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The study of ion channels represents one of the most active fields in neuroscience research in China.In the last 10 years,active research in various Chinese neuroscience institutions has sought to understand the mechanisms responsible for sensory processing,neural development and neurogenesis,neural plasticity,as well as pathogenesis.In addition,extensive studies have been directed to measure ion channel activity,structure-function relationships,as well as many other biophysical and biochemical properties.This review focuses on the progress achieved in the investigation of ion channels in neuronal survival during the past 10 years in China.

  9. Synchronization effects in a dual-wavelength class-B laser with modulated losses.

    Science.gov (United States)

    Kuntsevich, B F; Pisarchik, A N

    2001-10-01

    Different types of synchronization: in-phase, antiphase, phase, and lag synchronization, as well as amplitude death have been found theoretically in a dual-wavelength class-B laser with modulated losses in one of the channels. Depending on the laser parameters, oscillations in master and slave channels can be either completely or partially synchronized. The conditions for the dual-wavelength regime have been established. The analysis has been performed on the basis of transfer functions of the master and slave channels.

  10. Single-channel kinetics of BK (Slo1 channels

    Directory of Open Access Journals (Sweden)

    Yanyan eGeng

    2015-01-01

    Full Text Available Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca2+- and voltage-activated K+ (BK or Slo1 channels at the single-channel level. It starts with single-channel current records and progresses to presentation and analysis of single-channel data and the development of gating mechanisms in terms of discrete state Markov (DSM models. The DSM models are formulated in terms of the tetrameric modular structure of BK channels, consisting of a central transmembrane pore-gate domain (PGD attached to four surrounding transmembrane voltage sensing domains (VSD and a large intracellular cytosolic domain (CTD, also referred to as the gating ring. The modular structure and data analysis shows that the Ca2+ and voltage dependent gating considered separately can each be approximated by 10-state two-tiered models with 5 closed states on the upper tier and 5 open states on the lower tier. The modular structure and joint Ca2+ and voltage dependent gating are consistent with a 50 state two-tiered model with 25 closed states on the upper tier and 25 open states on the lower tier. Adding an additional tier of brief closed (flicker states to the 10-state or 50-state models improved the description of the gating. For fixed experimental conditions a channel would gate in only a subset of the potential number of states. The detected number of states and the correlations between adjacent interval durations are consistent with the tiered models. The examined models can account for the single-channel kinetics and the bursting behavior of gating. Ca2+ and voltage activate BK channels by predominantly increasing the effective opening rate of the channel with a smaller decrease in the effective closing rate. Ca2+ and depolarization thus activate by mainly destabilizing the closed states.

  11. Holographic Duals of Quark Gluon Plasmas with Unquenched Flavors

    Institute of Scientific and Technical Information of China (English)

    Francesco Bigazzi; Aldo Cotrone; Javier Mas; Daniel Mayerson; Javier Tarrio

    2012-01-01

    We review the construction of gravitational solutions holographically dual to N = 1 quiver gauge theories with dynamical flavor multiplets. We focus on the D3-D7 construction and consider the finite temperature, finite quark chemical potential case where there is a charged black hole in the dual solution. Discussed physical outputs of the model include its thermodynamics (with susceptibilities) and general hydrodynamic properties.

  12. Nonlinear channelizer

    Science.gov (United States)

    In, Visarath; Longhini, Patrick; Kho, Andy; Neff, Joseph D.; Leung, Daniel; Liu, Norman; Meadows, Brian K.; Gordon, Frank; Bulsara, Adi R.; Palacios, Antonio

    2012-12-01

    The nonlinear channelizer is an integrated circuit made up of large parallel arrays of analog nonlinear oscillators, which, collectively, serve as a broad-spectrum analyzer with the ability to receive complex signals containing multiple frequencies and instantaneously lock-on or respond to a received signal in a few oscillation cycles. The concept is based on the generation of internal oscillations in coupled nonlinear systems that do not normally oscillate in the absence of coupling. In particular, the system consists of unidirectionally coupled bistable nonlinear elements, where the frequency and other dynamical characteristics of the emergent oscillations depend on the system's internal parameters and the received signal. These properties and characteristics are being employed to develop a system capable of locking onto any arbitrary input radio frequency signal. The system is efficient by eliminating the need for high-speed, high-accuracy analog-to-digital converters, and compact by making use of nonlinear coupled systems to act as a channelizer (frequency binning and channeling), a low noise amplifier, and a frequency down-converter in a single step which, in turn, will reduce the size, weight, power, and cost of the entire communication system. This paper covers the theory, numerical simulations, and some engineering details that validate the concept at the frequency band of 1-4 GHz.

  13. Dual phase evolution

    CERN Document Server

    Green, David G; Abbass, Hussein A

    2014-01-01

    This book explains how dual phase evolution operates in all these settings and provides a detailed treatment of the subject. The authors discuss the theoretical foundations for the theory, how it relates to other phase transition phenomena and its advantages in evolutionary computation and complex adaptive systems. The book provides methods and techniques to use this concept for problem solving. Dual phase evolution concerns systems that evolve via repeated phase shifts in the connectivity of their elements. It occurs in vast range of settings, including natural systems (species evolution, landscape ecology, geomorphology), socio-economic systems (social networks) and in artificial systems (annealing, evolutionary computing).

  14. Dual differential polarimetry. A technique to recover polarimetric information from dual-polarization observations

    Science.gov (United States)

    Martí-Vidal, I.; Vlemmings, W. H. T.; Muller, S.

    2016-09-01

    Current mm/submm interferometers, like the Atacama Large mm/submm Array (ALMA), use receivers that register the sky signal in a linear polarization basis. In the case of observations performed in full-polarization mode (where the cross-correlations are computed among all the polarization channels) it is possible to reconstruct the full-polarization brightness distribution of the observed sources, as long as a proper calibration of delay offsets and leakage among polarization channels can be performed. Observations of calibrators, preferably with some linear polarization, with a good parallactic angle coverage are usually needed for such a calibration. In principle, dual-polarization observations only allow us to recover the Stokes I intensity distribution of the sources, regardless of the parallactic angle coverage of the observations. In this paper, we present a novel technique of dual differential polarimetry that makes it possible to obtain information related to the full-polarization brightness distribution of the observed sources from dual-polarization observations. This technique is inspired in the Earth-rotation polarization synthesis and can be applied even to sources with complex structures.

  15. Statistical-mechanical analysis of multiuser channel capacity with imperfect channel state information

    Institute of Scientific and Technical Information of China (English)

    Wang Hui-Song; Zeng Gui-Hua

    2008-01-01

    In this paper,the effect of imperfect channel state information at the receiver, which is caused by noise and other interference, on the multi-access channel capacity is analysed through a statistical-mechanical approach. Replica analyses focus on analytically studying how the minimum mean square error (MMSE) channel estimation error appears in a multiuser channel capacity formula. And the relevant mathematical expressions are derived. At the same time,numerical simulation results are demonstrated to validate the Replica analyses. The simulation results show how the system parameters, such as channel estimation error, system load and signal-to-noise ratio, affect the channel capacity.

  16. Commuting Dual Toeplitz Operators on the Polydisk

    Institute of Scientific and Technical Information of China (English)

    Yu Feng LU; Shu Xia SHANG

    2007-01-01

    On the polydisk, the commutativity of dual Toeplitz operators is studied. We obtain characterizations of commuting dual Toeplitz operators, essentially commuting dual Toeplitz operators and essentially semi-commuting dual Toeplitz operators.

  17. Subthreshold current model of fully depleted dual material gate SOI MOSFET

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Dual material gate SOI MOSFET with asymmetrical halo can suppress short channel effect and increase carriers transport efficiency. The analytical model of its subthreshold drain current is derived based on the explicit solution of two-dimensional Poisson's equation in the depletion region. The model takes into consideration the channel length modulation effect and the contribution of the back channel current component. Its validation is verified by comparision with two dimensional device simulator MEDICI.

  18. A DUAL RESERVATION CDMA-BASED MAC PROTOCOL WITH POWER CONTROL FOR AD HOC NETWORKS

    Institute of Scientific and Technical Information of China (English)

    Jia Min; Chen Huimin; Yuan Yuhua

    2007-01-01

    This paper proposes a new multi-channel Medium Access Control (MAC) protocol named as Dual Reservation Code Division Multiple Access (CDMA) based MAC protocol with Power Control (DRCPC). The code channel is divided into common channel, broadcast channel and several data channels. And dynamic power control mechanism is implemented to reduce near-far interference. Compared with IEEE 802.11 Distributed Coordination Function (DCF) protocol, the results show that the proposed mechanism improves the average throughput and limits the transmission delay efficiently.

  19. Early Dual Language Learning

    Science.gov (United States)

    Genesee, Fred

    2008-01-01

    Parents and child care personnel in English-dominant parts of the world often express misgivings about raising children bilingually. Their concerns are based on the belief that dual language learning during the infant-toddler stage confuses children, delays their development, and perhaps even results in reduced language competence. In this…

  20. Dual modality of non-contact photoacoustic tomography and fluorescence imaging using double cladding fiber

    Science.gov (United States)

    Eom, Jonghyun; Park, Seong Jun; Kim, Ju Wan; Park, Soongho; Lee, Byeong Ha

    2015-03-01

    We present a fiber-based dual-modal imaging system that combines non-contact photoacoustic tomography (NCPAT) and fluorescence imaging by using double cladding fiber (DCF). The NCPAT system utilizing an all-fiber heterodyne interferometer as an ultrasound detector measures the photoacoustic signal at the sample surface without physical contact. Fluorescence imaging system is composed of fiber-optics to deliver the excitation light and the emission light. For combined system the probe consists of a specially fabricated DCF coupler and a lensed fiber so that we can simultaneously acquire the signals of two systems with the same probe. The DCF has a core and two claddings, inner and outer, which allows two concentric light-guiding channels via the core and the inner cladding. The lensed fiber of the DCF probe is compactly fabricated to focus the interferometer light and the excitation light, and to efficiently collect the fluorescence signal. To demonstrate the feasibility of the proposed dual-modal system, we have conducted phantom experiments using tissue mimicking phantoms which contained a couple of tubes filled with fluorescein solution and black ink, respectively. The proposed imaging system is implanted with fiber-optic configurations so that it has the potential for minimally invasive and improved diagnosis and guided treatment of diseases.

  1. Comparison of the far wake behind dual rotor and dual disk configurations

    Science.gov (United States)

    Okulov, V. L.; Mikkelsen, R. F.; Naumov, I. V.; Litvinov, I. V.; Gesheva, E.; Sørensen, J. N.

    2016-09-01

    There is an increasing interest in studying the development of far wakes behind two or more interacting wind turbines in order to determine the influence of wake interaction in relation to the design of wind farms. The focus of this experimental study is to understand and describe the resulting wake features for two rotors subjected to different operating and spatial conditions. As a part of this, a comparison with the wake development behind two disks replacing the rotor models was performed to determine the difference between the two wake systems. LDA and Stereo PIV experiments were carried out to study the development of far wakes behind configurations of dual HAWT wind turbine rotors and dual circular disks. The setups were placed in the middle of a water flume. The initial flow in the flume is subjected to a very low turbulence level, limiting the influence of all external disturbances in order to focus the study to the inherent wake instability. As a result of the investigation, we obtained decays of profiles for the velocity deficit and turbulent pulsations in the far wakes behind both dual rotor and dual disk configurations. By using regression techniques to fit the obtained velocity profiles the experimental data were approximated by identical analytical models and compared to each other. An identical rational dependence with the same powers, but with different coefficients, was found for the two configurations.

  2. Dual use research: investigation across multiple science disciplines.

    Science.gov (United States)

    Oltmann, Shannon

    2015-04-01

    Most recent studies of dual use research have focused on the life sciences, although some researchers have suggested that dual use research occurs across many disciplines. This research is an initial investigation into the prevalence of dual use research in other scientific disciplines by surveying senior editors of scientific journals, drawn from Journal Citation Reports. The survey was emailed to 7,500 journal editors with a response rate of 10.1 %. Approximately 4.8 % of life science editors reported they had to consider whether to publish dual use research and 38.9 % said they decided to not publish the research in question. In disciplines other than the life sciences, 7.2 % of editors from other science disciplines reported that they had to consider whether to publish dual use research, and 48.4 % declined to publish it. The survey investigated relationships between dual use and the journal's source of funding and place of publication, but no relationships were found. Further research is needed to better understand the occurrence of dual use research in other science disciplines.

  3. Population thinking and natural selection in dual-inheritance theory.

    Science.gov (United States)

    Houkes, Wybo

    2012-05-01

    A deflationary perspective on theories of cultural evolution, in particular dual-inheritance theory, has recently been proposed by Lewens. On this 'pop-culture' analysis, dual-inheritance theorists apply population thinking to cultural phenomena, without claiming that cultural items evolve by natural selection. This paper argues against this pop-culture analysis of dual-inheritance theory. First, it focuses on recent dual-inheritance models of specific patterns of cultural change. These models exemplify population thinking without a commitment to natural selection of cultural items. There are grounds, however, for doubting the added explanatory value of the models in their disciplinary context-and thus grounds for engaging in other potentially explanatory projects based on dual-inheritance theory. One such project is suggested by advocates of the theory. Some of the motivational narratives that they offer can be interpreted as setting up an adaptationist project with regard to cumulative change in cultural items. We develop this interpretation here. On it, dual-inheritance theory features two interrelated selection processes, one on the level of genetically inherited learning mechanisms, another on the level of the cultural items transmitted through these mechanisms. This interpretation identifies a need for further modelling efforts, but also offers scope for enhancing the explanatory power of dual-inheritance theory.

  4. Aircraft Engine Sensor Fault Diagnostics Through Dual-Channel Sensor Measurements Based on a Bank of Hybrid Kalman Filters%基于混合卡尔曼滤波器组的航空发动机双通道传感器故障检测

    Institute of Scientific and Technical Information of China (English)

    张书刚; 郭迎清; 陆军

    2012-01-01

    Based on a bank of hybrid Kalman filters which are hybrids of a nonlinear on-board engine model (NOBEM) and piecewise linear Kalman fillers, a civil aircraft engine sensor fault diagnostics system which utilizes dual -channel sensor measurements is developed. Principles and algorithms of sensor fault detection, isolation and accommodation are given. By this system applied to some typical civil turbo-fan engine sensor faults, simulation results show that the diagnostic effectiveness of the system is maintained to avoid false alarms as the health of the engine degrades over time through a simple process: by feeding the health degradation values into the NUBEM and not changing the parameters of the linear Kalman filters. The update process, which can be completed automatically online to save time and effort, is feasible in the real application environment.%基于机载非线性模型与分段线性卡尔曼滤波器混合组成的混合卡尔曼滤波器组,结合双通道传感器的特点,建立了民用航空发动机传感器故障诊断系统;给出故障诊断原理及算法的同时,将该系统应用于民用涡扇发动机传感器常见典型故障进行了仿真;仿真结果表明,诊断系统可以在发动机发生健康蜕化后,通过只简单更新机载模型的蜕化因子,而保持线性卡尔曼滤波器的参数不变,便能准确地检测和隔离各类传感器故障而不发生误报;该更新过程可以在线自动完成,省时省力,易于工程实现.

  5. Dual Double Field Theory

    CERN Document Server

    Bergshoeff, Eric A; Penas, Victor A; Riccioni, Fabio

    2016-01-01

    We present the dual formulation of double field theory at the linearized level. This is a classically equivalent theory describing the duals of the dilaton, the Kalb-Ramond field and the graviton in a T-duality or O(D,D) covariant way. In agreement with previous proposals, the resulting theory encodes fields in mixed Young-tableau representations, combining them into an antisymmetric 4-tensor under O(D,D). In contrast to previous proposals, the theory also requires an antisymmetric 2-tensor and a singlet, which are not all pure gauge. The need for these additional fields is analogous to a similar phenomenon for "exotic" dualizations, and we clarify this by comparing with the dualizations of the component fields. We close with some speculative remarks on the significance of these observations for the full non-linear theory yet to be constructed.

  6. Higher Representations Duals

    DEFF Research Database (Denmark)

    Sannino, Francesco

    2010-01-01

    We uncover novel solutions of the 't Hooft anomaly matching conditions for scalarless gauge theories with matter transforming according to higher dimensional representations of the underlying gauge group. We argue that, if the duals exist, they are gauge theories with fermions transforming...... according to the defining representation of the dual gauge group. The resulting conformal windows match the one stemming from the all-orders beta function results when taking the anomalous dimension of the fermion mass to be unity which are also very close to the ones obtained using the Schwinger......-Dyson approximation. We use the solutions to gain useful insight on the conformal window of the associated electric theory. A consistent picture emerges corroborating previous results obtained via different analytic methods and in agreement with first principle lattice explorations....

  7. Dual-readout Calorimetry

    CERN Document Server

    Akchurin, N; Cardini, A.; Cascella, M.; Cei, F.; De Pedis, D.; Fracchia, S.; Franchino, S.; Fraternali, M.; Gaudio, G.; Genova, P.; Hauptman, J.; La Rotonda, L.; Lee, S.; Livan, M.; Meoni, E.; Moggi, A.; Pinci, D.; Policicchio, A.; Saraiva, J.G.; Sill, A.; Venturelli, T.; Wigmans, R.

    2013-01-01

    The RD52 Project at CERN is a pure instrumentation experiment whose goal is to un- derstand the fundamental limitations to hadronic energy resolution, and other aspects of energy measurement, in high energy calorimeters. We have found that dual-readout calorimetry provides heretofore unprecedented information event-by-event for energy resolution, linearity of response, ease and robustness of calibration, fidelity of data, and particle identification, including energy lost to binding energy in nuclear break-up. We believe that hadronic energy resolutions of {\\sigma}/E $\\approx$ 1 - 2% are within reach for dual-readout calorimeters, enabling for the first time comparable measurement preci- sions on electrons, photons, muons, and quarks (jets). We briefly describe our current progress and near-term future plans. Complete information on all aspects of our work is available at the RD52 website http://highenergy.phys.ttu.edu/dream/.

  8. Dual-comb MIXSEL

    Science.gov (United States)

    Link, S. M.; Zaugg, C. A.; Klenner, A.; Mangold, M.; Golling, M.; Tilma, B. W.; Keller, U.

    2015-03-01

    We present a single semiconductor disk laser simultaneously emitting two different gigahertz modelocked pulse trains. A birefringent crystal inside a modelocked integrated external-cavity surface-emitting laser (MIXSEL) separates the cavity beam into two spatially separated beams with perpendicular polarizations on the MIXSEL chip. This MIXSEL then generates two orthogonally polarized collinear modelocked pulse trains from one simple straight cavity. Superimposing the beams on a photo detector creates a microwave beat signal, representing a strikingly simple setup to down-convert the terahertz optical frequencies into the electronically accessible microwave regime. This makes the dual-comb MIXSEL scheme an ultra-compact and cost-efficient candidate for dual-comb spectroscopy applications.

  9. Dual-readout Calorimetry

    OpenAIRE

    Akchurin, N.; Bedeschi, F.; Cardini, A.; Cascella, M.; Cei, F.; Pedis, D.; Fracchia, S.; Franchino, S.; Fraternali, M.; Gaudio, G.; P. Genova; Hauptman, J.; La Rotonda, L.; Lee, S.; Livan, M.(INFN Sezione di Pavia, Pavia, Italy)

    2013-01-01

    The RD52 Project at CERN is a pure instrumentation experiment whose goal is to understand the fundamental limitations to hadronic energy resolution, and other aspects of energy measurement, in high energy calorimeters. We have found that dual-readout calorimetry provides heretofore unprecedented information event-by-event for energy resolution, linearity of response, ease and robustness of calibration, fidelity of data, and particle identification, including energy lost to binding energy in n...

  10. Beyond the Manual Channel

    DEFF Research Database (Denmark)

    , the main focus there is on spoken languages in their written and spoken forms. This series of workshops, however, offers a forum for researchers focussing on sign languages. For the fourth time, the workshop had sign language corpora as its main topic. This time, the focus was on any aspect beyond......This collection of papers stems from the Sixth Workshop on the Representation and Processing of Sign Languages, held in May 2014 as a satellite to the Language Resources and Evaluation Conference in Reykjavik. While there has been occasional attention for sign languages at the main LREC conference...... the manual channel. Not surprisingly, most papers deal with non-manuals on the face. Once again, the papers at this workshop clearly identify the potentials of even closer cooperation between sign linguists and sign language engineers, and we think it is events like this that contribute a lot to a better...

  11. Back Channelling, Repair, Pausing, and Private Speech.

    Science.gov (United States)

    White, Ron

    1997-01-01

    Focuses on differences in back channelling, repair, repetition, pausing, and private speech among Japanese and American study participants, based on sales negotiations. Findings indicate that differences in the deployment of such features as back channelling and pausing can result in pragma-linguistic breakdown, which is linked to culturally…

  12. Fiber and Crystals Dual Readout calorimeters

    CERN Document Server

    Cascella, Michele; Lee, Sehwook

    2016-01-01

    The RD52 (DREAM) collaboration is performing R\\&D on dual readout calorimetry techniques with the aim of improving hadronic energy resolution for future high energy physics experiments. The simultaneous detection of Cherenkov and scintillation light enables us to measure the electromagnetic fraction of hadron shower event-by-event. As a result, we could eliminate the main fluctuation which prevented from achieving precision energy measurement for hadrons. We have tested the performance of the lead and copper fiber prototypes calorimeters with various energies of electromagnetic particles and hadrons. During the beam test, we investigated the energy resolutions for electrons and pions as well as the identification of those particles in a longitudinally unsegmented calorimeter. Measurements were also performed on pure and doped PbWO$_{4}$ crystals, as well as BGO and BSO, with the aim of realising a crystal based dual readout detector. We will describe our results, focusing on the more promising properties ...

  13. Influence of geometry on hydrodynamic focusing and long-range fluid behavior in PDMS microfluidic chips

    DEFF Research Database (Denmark)

    Kunstmann-Olsen, Casper; Hoyland, James; Rubahn, Horst-Günter

    2012-01-01

    Details of hydrodynamic focusing in a 2D microfluidic channel-junction are investigated experimentally and theoretically, especially the effect on the focusing width of volumetric flow ratio r between main and side channels, as well as angle θ between channels. A non-linear relationship is observ...

  14. Dual constellations space-time modulation

    Institute of Scientific and Technical Information of China (English)

    ZOU Li; ZHAO Yuping; WANG Bing; LIANG Qinglin; XIANG Haige

    2005-01-01

    Next generation communication systems will be expected to operate under environment with high-speed motion and increasing number of antennas where it will be difficult or even impractical to estimate the real-time channel coefficients. For this reason,the DSTM (differential space time modulation) and USTM (unitary space time modulation) approaches that do not require the channel estimation became hot topics in recent years.In this paper, we propose a general approach to designing high spectral-efficiency signaling schemes. A novel modulation, dual constellations space-time modulation (DCSTM), is derived by extending DSTM and USTM theoretically. DCSTM preserves the good features of USTM such as low error rate and the capability of being demodulated without channel estimation. At the same time, it enhances the spectral efficiency and reduces the complexity of the modulation/demodulation. It can be adapted to different data rates and thus has a wider applicable area. Simulation results verify the theoretical analysis and the design of the new modulation method.

  15. Quantum-corrected self-dual black hole entropy in tunneling formalism with GUP

    Directory of Open Access Journals (Sweden)

    M.A. Anacleto

    2015-10-01

    Full Text Available In this paper we focus on the Hamilton–Jacobi method to determine the entropy of a self-dual black hole by using linear and quadratic GUPs (generalized uncertainty principles. We have obtained the Bekenstein–Hawking entropy of self-dual black holes and its quantum corrections that are logarithm and also of several other types.

  16. Quantum-corrected self-dual black hole entropy in tunneling formalism with GUP

    Energy Technology Data Exchange (ETDEWEB)

    Anacleto, M.A., E-mail: anaclet@df.ufcg.edu.br [Departamento de Física, Universidade Federal de Campina Grande, Caixa Postal 10071, 58109-970 Campina Grande, Paraíba (Brazil); Brito, F.A., E-mail: fabrito@df.ufcg.edu.br [Departamento de Física, Universidade Federal de Campina Grande, Caixa Postal 10071, 58109-970 Campina Grande, Paraíba (Brazil); Departamento de Física, Universidade Federal da Paraíba, Caixa Postal 5008, 58051-970 João Pessoa, Paraíba (Brazil); Passos, E., E-mail: passos@df.ufcg.edu.br [Departamento de Física, Universidade Federal de Campina Grande, Caixa Postal 10071, 58109-970 Campina Grande, Paraíba (Brazil)

    2015-10-07

    In this paper we focus on the Hamilton–Jacobi method to determine the entropy of a self-dual black hole by using linear and quadratic GUPs (generalized uncertainty principles). We have obtained the Bekenstein–Hawking entropy of self-dual black holes and its quantum corrections that are logarithm and also of several other types.

  17. Interinstitutional Collaboration Practices between Virginia Community Colleges and High Schools Involved in Dual Enrollment Articulation Agreements

    Science.gov (United States)

    Caradona, Sally Lynn

    2012-01-01

    The purpose of this study was to build on the previous work of articulation practices of Virginia's public school divisions and community colleges participating in dual enrollment partnerships, and to understand the role of the community college in initiating, developing, and implementing dual enrollment programs. The primary focus involved…

  18. Alexander Duals of Multipermutohedron Ideals

    Indian Academy of Sciences (India)

    Ajay Kumar; Chanchal Kumar

    2014-02-01

    An Alexander dual of a multipermutohedron ideal has many combinatorial properties. The standard monomials of an Artinian quotient of such a dual correspond bijectively to some -parking functions, and many interesting properties of these Artinian quotients are obtained by Postnikov and Shapiro (Trans. Am. Math. Soc. 356 (2004) 3109–3142). Using the multigraded Hilbert series of an Artinian quotient of an Alexander dual of multipermutohedron ideals, we obtained a simple proof of Steck determinant formula for enumeration of -parking functions. A combinatorial formula for all the multigraded Betti numbers of an Alexander dual of multipermutohedron ideals are also obtained.

  19. Multi-Threshold Dual-Spacer Dual-Rail Delay-Insensitive Logic (MTD3L: A Low Overhead Secure IC Design Methodology

    Directory of Open Access Journals (Sweden)

    Michael Linder

    2013-10-01

    Full Text Available As portable devices become more ubiquitous, data security in these devices is becoming increasingly important. Traditional circuit design techniques leave otherwise secure systems vulnerable due to the characteristics of the hardware implementation, rather than weaknesses in the security algorithms. These characteristics, called side-channels, are exploitable because they can be measured and correlated with processed data, potentially giving an attacker insight into the device’s secret data. Alternative design techniques such as dual-rail asynchronous designs are capable of minimizing these potential side-channels by decoupling them from the data being processed. However, these techniques are either expensive to implement compared to standard designs or leave exploitable imbalances in the dual-rail implementation itself. Multi-Threshold Dual-Spacer Dual-Rail Delay-Insensitive Logic (MTD3L offers security by balancing side-channels both in general and between the dual-rail signals themselves, as well as reduction in circuit overhead compared to previous secure design techniques. Results show that the Advanced Encryption Standard (AES cores designed using MTD3L exhibit similar security to previous secure techniques with substantially less area and energy overhead.

  20. Channel capacity and digital modulation schemes in correlated Weibull fading channels with nonidentical statistics

    Institute of Scientific and Technical Information of China (English)

    Xiao Hailin; Nie Zaiping; Yang Shiwen

    2007-01-01

    The novel closed-form expressions for the average channel capacity of dual selection diversity is presented, as well as, the bit-error rate (BER) of several coherent and noncoherent digital modulation schemes in the correlated Weibull fading channels with nonidentical statistics.The results are expressed in terms of Meijer's Gfunction, which can be easily evaluated numerically.The simulation results are presented to validate the proposed theoretical analysis and to examine the effects of the fading severity on the concerned quantities.

  1. The use of low power dual mode nuclear thermal rocket engines to support space exploration missions

    Science.gov (United States)

    Zubrin, Robert M.

    1991-01-01

    The evolution of dual mode concepts is presented, focusing on advantages and problems associated with both low and high temperature dual mode conversion systems. It is concluded that dual mode nuclear thermal rocket (NTR) systems using high temperature Brayton cycle conversion technology offer a high payoff enhancement of conventional NTR, with a comparatively minor increase of technological challenge. It is recommended that NTR engines be designed so that dual mode conversion systems can be attached to them in a modular way, thus enabling the production of electric power on all missions where it is needed.

  2. The Power of Integrators, Financiers, and Insurers to Reduce Proliferation Risks: Nuclear Dual-Use Goods

    Energy Technology Data Exchange (ETDEWEB)

    Weise, Rachel A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hund, Gretchen [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-05-01

    Globalization of manufacturing supply chains has changed the nature of nuclear proliferation. Before 1991, nonproliferation efforts focused almost exclusively on limiting the spread of materials and equipment specifically designed for nuclear use -- reactors, centrifuges, and fissile material. Dual-use items, those items with both nuclear and non-nuclear applications, were not closely scrutinized or controlled. However, in 1991 the international community discovered that Iraq had developed a fairly sophisticated nuclear weapons program by importing dual-use items; this discovery spurred the international community to increase controls on dual-use technologies. Despite these international efforts, dual-use items are still a challenge for those seeking to limit proliferation.

  3. Dual cure photocatalyst systems

    Energy Technology Data Exchange (ETDEWEB)

    DeVoe, R.J.; Brown-Wensley, K.A.; Holmes, G.L.; Mathis, M.D.; McCormick, F.B.; Palazzotto, M.C.; Spurgeon, K.M. (Minnesota Mining and Mfg. Co., St. Paul, MN (USA). Corporate Research Labs.)

    1990-01-01

    A family of dual cure photocatalyst systems is being developed to be used in the solventless processing of organic coatings. The photocatalyst systems consist of organometallic compounds often in combination with other agents. Upon photolysis, the photocatalyst system generates a Lewis acid and a free radical. The Lewis acid can initiate the polymerization of epoxies or the addition of isocyanates and polyols to form polyurethanes while the free radical can initiate the polymerization of acrylates. The performance of the various photocatalyst systems will be compared on the basis of the physical properties of the cured compositions they produce. 17 figs.

  4. Tuning particle focusing in inertial microfluidic devices

    Science.gov (United States)

    Hood, Kaitlyn; Kahkeshani, Soroush; di Carlo, Dino; Roper, Marcus

    2014-11-01

    Particles in microfluidic devices at finite Reynolds number are subject to two forces: (i) inertial focusing and (ii) particle-particle interactions. Although microfluidic chips exploit these forces to manipulate particles for particle/cell sorting and high throughput flow cytometry, the forces are not understood well enough to allow rational design of devices that can tune and attenuate particle focusing. We present a mathematical model addressing both inertial focusing and particle interactions, and we apply our model to various channel geometries to determine the balance of forces. In addition, we present experimental data that illustrate the accuracy of our model. We will address the following questions: Why do high aspect ratio channels favor two equilibrium positions? Why do particle chains form?

  5. Molecular biology of insect sodium channels and pyrethroid resistance.

    Science.gov (United States)

    Dong, Ke; Du, Yuzhe; Rinkevich, Frank; Nomura, Yoshiko; Xu, Peng; Wang, Lingxin; Silver, Kristopher; Zhorov, Boris S

    2014-07-01

    Voltage-gated sodium channels are essential for the initiation and propagation of the action potential in neurons and other excitable cells. Because of their critical roles in electrical signaling, sodium channels are targets of a variety of naturally occurring and synthetic neurotoxins, including several classes of insecticides. This review is intended to provide an update on the molecular biology of insect sodium channels and the molecular mechanism of pyrethroid resistance. Although mammalian and insect sodium channels share fundamental topological and functional properties, most insect species carry only one sodium channel gene, compared to multiple sodium channel genes found in each mammalian species. Recent studies showed that two posttranscriptional mechanisms, alternative splicing and RNA editing, are involved in generating functional diversity of sodium channels in insects. More than 50 sodium channel mutations have been identified to be responsible for or associated with knockdown resistance (kdr) to pyrethroids in various arthropod pests and disease vectors. Elucidation of molecular mechanism of kdr led to the identification of dual receptor sites of pyrethroids on insect sodium channels. Many of the kdr mutations appear to be located within or close to the two receptor sites. The accumulating knowledge of insect sodium channels and their interactions with insecticides provides a foundation for understanding the neurophysiology of sodium channels in vivo and the development of new and safer insecticides for effective control of arthropod pests and human disease vectors.

  6. On one-qubit channels

    CERN Document Server

    Verstraete, F; Verstraete, Frank; Verschelde, Henri

    2002-01-01

    We use the duality between completely positive linear maps and states to characterize all possible 1-qubit channels. This leads to a transparent way of characterizing all extreme points of the set of completely positive trace preserving maps. We show that these extremal maps arise in a natural way in problems such as to optimally enhance fidelity and optimal cloning. Next we use normal forms, previously derived for mixed states of two qubits, to derive interesting representations of CP-maps. It follows that a generic CP-map on 1 qubit can be interpreted as being a composition of a (reversible) filtering operation, followed by a unital map, followed by filtering again. It is furthermore shown that a map is entanglement breaking iff the dual state associated to it is separable, and how this implies that the Kraus operators can be chosen to be all of rank one.

  7. Composite behaviors of dual meminductor circuits

    Institute of Scientific and Technical Information of China (English)

    郑辞晏; 于东升; 梁燕; 陈孟科

    2015-01-01

    This paper focuses on analyzing the composite dynamic behaviors of two meminductors in serial and parallel connec-tions with different polarities. Based on the constitutive relations, two time-integral-of-flux (TIF) controlled meminductors are adopted to theoretically demonstrate the variation of memductance in terms of TIF, charge, flux, and current. By uti-lizing a floating memristor-less meminductor emulator, the theoretical analysis reported in this paper is confirmed via a PSPICE simulation study and hardware experiment. Good agreement among theoretical analysis, simulation, and hardware validation confirms that dual meminductor circuits in composite connections behave as a new meminductor with higher complexity.

  8. Channel Measurements and Characteristics for Cooperative Positioning Applications

    DEFF Research Database (Denmark)

    Wang, Wei; Steinböck, Gerhard; Jost, Thomas;

    2012-01-01

    We have conducted an indoor channel measurement campaign to characterize the propagation channel for the development of cooperative positioning algorithms. The campaign focused particularly on the characteristics of multi-link channels with applications to positioning. In this contribution we pre...

  9. Transmission Channels of Monetary Policy: A Broader View

    Directory of Open Access Journals (Sweden)

    Lukáš Kučera

    2016-08-01

    Full Text Available The paper deals with a transmission mechanism of monetary policy under the regime of inflation targeting. It focuses on the expectations channel, the credit view and the cost channel. These channels work side by side and may amplify effects of the traditional view of transmission mechanisms of monetary policy, which emphasises adjustments on the demand side.

  10. Joint Channel Estimation and Data Detection for Multihop OFDM Relaying System under Unknown Channel Orders and Doppler Frequencies

    CERN Document Server

    Min, Rui

    2012-01-01

    In this paper, channel estimation and data detection for multihop relaying orthogonal frequency division multiplexing (OFDM) system is investigated under time-varying channel. Different from previous works, which highly depend on the statistical information of the doubly-selective channel (DSC) and noise to deliver accurate channel estimation and data detection results, we focus on more practical scenarios with unknown channel orders and Doppler frequencies. Firstly, we integrate the multilink, multihop channel matrices into one composite channel matrix. Then, we formulate the unknown channel using generalized complex exponential basis expansion model (GCE-BEM) with a large oversampling factor to introduce channel sparsity on delay-Doppler domain. To enable the identification of nonzero entries, sparsity enhancing Gaussian distributions with Gamma hyperpriors are adopted. An iterative algorithm is developed under variational inference (VI) framework. The proposed algorithm iteratively estimate the channel, re...

  11. Spatial Confinement of Ultrasonic Force Fields in Microfluidic Channels

    DEFF Research Database (Denmark)

    Manneberg, O; Hagsäter, Melker; Svennebring, J;

    2009-01-01

    of the microfluidic channel. The channel segments are remotely actuated by the use of frequency-specific external transducers with refracting wedges placed on top of the chips. The force field in each channel segment is characterized by the use of micrometer-resolution particle image velocimetry ( micro......-PIV). The confinement of the ultrasonic fields during single-or dual-segment actuation, as well as the cross-talk between two adjacent. fields, is characterized and quantified. Our results show that the field confinement typically scales with the acoustic wavelength, and that the cross-talk is insignificant between...

  12. Dual Card,Double Happiness

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    As Christmas Day and New Year Day draw near, why not treat yourself with a smart digital gizmo. Then, the Samsung Dual-card Cellphone is what you are longing for. Samsung B5712C, the first dual-card model released by Samsung,

  13. Asymmetry in Dual Language Practice

    Directory of Open Access Journals (Sweden)

    Audrey Amrein

    2000-01-01

    Full Text Available The capacity for dual-language programs to deliver specific benefits to students with different primary and secondary language skills continues to be debated. Individuals favoring dual language assert that as it relies upon a reciprocal approach, dual language students acquire dual language proficiency without the need for teachers to translate from one language to another. By utilizing and conserving the language skills that students bring, dual language students also gain cross-cultural understandings and an expanded opportunity to realize academic success in the future. Research that explores whether these programs meet the needs of monolingual and bilingual students is limited. The intent of this study is not to criticize dual language practice. Instead, it is to describe a newly implemented dual language immersion program that exists and operates in Phoenix, Arizona. In particular, this study examines the practices of dual language teachers at Leigh Elementary School and the challenges encountered as school personnel worked to provide students with different primary and secondary language skills increased opportunities to learn.

  14. Robust dual-response optimization

    NARCIS (Netherlands)

    Yanikoglu, Ihsan; den Hertog, Dick; Kleijnen, J.P.C.

    2016-01-01

    This article presents a robust optimization reformulation of the dual-response problem developed in response surface methodology. The dual-response approach fits separate models for the mean and the variance and analyzes these two models in a mathematical optimization setting. We use metamodels esti

  15. DUAL TRAINING IN RUSSIA: FROM THE CONCEPT TO PRACTICE

    Directory of Open Access Journals (Sweden)

    Alexander A. Listvin

    2016-01-01

    Full Text Available The purpose of the present article is to judge and justify the conditions of system elements application of dual training at implementation of programs of professional education for increase of efficiency of functioning and quality of preparation of qualified personnel by institutions of the secondary professional education (SPE. Methods. The methods used in work involve the comparative analysis of practice of application of dual training in system of professional education of Germany and regions of Russia for the purpose of identification of the existing problems and definition of optimum organizational and legal and didactic conditions. Results. The essence of system of dual training, its strong and weaknesses reveals. Necessary and indispensable conditions of application of dual training in modern regional systems of professional education are proved. Scientific novelty. According to the author, modern publications on problems and ways of development of professional education in Russia contain enough antinomy of standard and legal and organizational and administrative character. In particular, operating by the concept «dual education», an identification of the practice-focused and dual training introduction «the list 50 of the most demanded in labor market, the new and perspective professions that demand secondary professional education» as opposed to the existing list of professions and the constitutional guarantee of public and free secondary professional education. Standard and legal, and didactic conditions of application of elements of dual training in regional systems of professional education are proved theoretically. Practical significance. Implementation of the research outcomes can be useful to pedagogical staff of institutions of secondary professional education, representatives of employers and Chambers of Commerce and Industry to the organization and use of system of dual training in training of skilled workers (serving

  16. A Perspective on the MIMO Wiretap Channel

    KAUST Repository

    Oggier, Frederique

    2015-10-01

    A wiretap channel is a communication channel between a transmitter Alice and a legitimate receiver Bob, in the presence of an eavesdropper Eve. The goal of communication is to achieve reliability between Alice and Bob, but also confidentiality despite Eve’s presence. Wiretap channels are declined in all kinds of flavors, depending on the underlying channels used by the three players: discrete memoryless channels, additive Gaussian noise channels, or fading channels, to name a few. In this survey, we focus on the case where the three players use multiple-antenna channels with Gaussian noise to communicate. After summarizing known results for multiple-input–multiple-output (MIMO) channels, both in terms of achievable reliable data rate (capacity) and code design, we introduce the MIMO wiretap channel. We then state the MIMO wiretap capacity, summarize the idea of the proof(s) behind this result, and comment on the insights given by the proofs on the physical meaning of the secrecy capacity. We finally discuss design criteria for MIMO wiretap codes.

  17. 大视场宽谱段高分辨率分波段机载紫外-可见光成像光谱仪设计%Design of Airborne Dual Channel Ultraviolet-Visible Imaging Spectrometer with Large Field of View,Wide Spectrum, and High Resolution

    Institute of Scientific and Technical Information of China (English)

    郝爱花; 胡炳樑; 白加光; 李立波; 于涛; 李思远

    2013-01-01

    紫外-可见光(200~500 nm )成像光谱仪是空间遥感的重要组成部分,本文基于机载紫外-可见成像光谱仪的特殊性和实际应用要求,提出了一种采用面阵CCD的摆扫式成像光谱仪,这样既克服了传统线阵CCD摆扫式成像光谱仪空间分辨率低的缺点,同时又弥补了推扫式成像光谱仪视场范围有限的缺点,能够满足大视场、宽谱段、高分辨率成像光谱仪的应用要求;此外,考虑400~500 nm波段中200~250 nm波段二级光谱的影响和<290 nm的短波区和>310 nm的长波区两个波段相差3个数量级的辐射波动,采用了分波段、分系统的方式独立进行消杂光光谱成像。在系统结构设计方面,本着高性能、低成本的设计理念,选用了两镜同心系统作为望远系统,Czerny-T urner平面光栅结构作为成像光谱仪系统的光学设计方案;设计了一种不使用任何辅助光学元件,全部采用球面镜结构的成像光谱仪。整个系统结构简单、紧凑,性能优良,可行性好。全谱段、全视场调制传递函数值在0.6以上。%The ultraviolet-visible (UV-Vis 200~500 nm) imaging spectrometer is an important part of space remote sensing . Based on special requirements and practical application of the airborne UV-VIS spectrometer ,a kind of scanning imaging spec-trometer using area array CCD is proposed ,which can meet the application requirements of large field of view ,wide spectrum and high resolution .It overcomes low spatial resolution of traditional line array CCD scanning imaging spectrometer ,and limited field of view of the pushbroom imaging spectrometer .In addition ,dual channel was designed to reduce stray light .400~500 nm band includes two order spectrum for 200~250 nm band ,and variation of radiance from earth between the shorter wavelength (310 nm) is above three orders of magnitude .In the structure design of the system , the imaging spectrometer is

  18. Dual channel real-time PCR melting curve analysis-based assay for detecting of anti-tuberculosis drug-resistant mutations in Mycobacterium tuberculosis%双通道实时荧光PCR熔解曲线法检测结核分枝杆菌药物耐药相关基因突变

    Institute of Scientific and Technical Information of China (English)

    柳清云; 罗涛; 李静; 梅建; 高谦

    2013-01-01

    目的 基于双标记荧光探针熔解曲线分析技术,建立一种利用实时荧光PCR快速检测结核分枝杆菌耐药突变的方法.方法 根据结核分枝杆菌一线药物常见耐药突变位点(包括rpoB 81 bp耐药决定区、inhA启动子、katG315、ahpC启动子以及embB306)设计6条荧光双标记探针和对应引物,通过PCR扩增耐药突变位点所在基因片段,在扩增完成后通过熔解曲线检测分析实现对耐药突变的快速检测.通过对2008年上海市疾控中心收集的76株临床耐多药(MDR)菌株进行检测,验证本方法的敏感度和特异度.结果 本方法成功从76株MDR菌株中检测出相关耐药突变,各种突变对应ATm值范围为1.8~14.4℃.将检测结果和测序结果对比表明该方法检测敏感度和特异度都为100%(rpoB,80/80:inhA,7/7;katG315,59/59;ahpC,8/8;embB306,27/27).本方法可以成功从最低浓度为100拷贝/μl的结核分枝杆菌DNA样本中准确地检测耐药突变.结论 双通道实时荧光PCR熔解曲线法可以快速灵敏地检测结核分枝杆菌常见耐药突变.该方法具有检测迅速准确、结果易判读、交叉污染概率低等特点,可用于快速检测临床结核耐药相关的基因突变,并对结核耐药情况进行评估.%Objective Based on dual channel melting curve analysis-based assay,we developed a method to rapidly detect the drug-resistant mutations in Mycobacterium tuberculosis through real-time PCR.Methods According to the common first-line drug-resistant mutations of Mycobacterium tuberculosis,we designed six dual-labeled fluorescence probes to rapidly detect the drug-resistant mutations through realtime PCR melting curve after amplifications of drug-resistant related gene region of DNA.The targets include rpoB 81 bp core region,katG315,inhA promoter,ahpC promoter and embB306.To validate the sensitivity and specificity of our method,we performed real-time PCR assays to detect drug-resistant mutations in 76

  19. Channel incision and water quality

    Science.gov (United States)

    Shields, F. D.

    2009-12-01

    Watershed development often triggers channel incision that leads to radical changes in channel morphology. Although morphologic evolution due to channel incision has been documented and modeled by others, ecological effects, particularly water quality effects, are less well understood. Furthermore, environmental regulatory frameworks for streams frequently focus on stream water quality and underemphasize hydrologic and geomorphic issues. Discharge, basic physical parameters, solids, nutrients (nitrogen and phosphorus), chlorophyll and bacteria were monitored for five years at two sites along a stream in a mixed cover watershed characterized by rapid incision of the entire channel network. Concurrent data were collected from two sites on a nearby stream draining a watershed of similar size and cultivation intensity, but without widespread incision. Data sets describing physical aquatic habitat and fish fauna of each stream were available from other studies. The second stream was impacted by watershed urbanization, but was not incised, so normal channel-floodplain interaction maintained a buffer zone of floodplain wetlands between the study reach and the urban development upstream. The incised stream had mean channel depth and width that were 1.8 and 3.5 times as large as for the nonincised stream, and was characterized by flashier hydrology. The median rise rate for the incised stream was 6.4 times as great as for the nonincised stream. Correlation analyses showed that hydrologic perturbations were associated with water quality degradation, and the incised stream had levels of turbidity and solids that were two to three times higher than the nonincised, urbanizing stream. Total phosphorus, total Kjeldahl N, and chlorophyll a concentrations were significantly higher in the incised stream, while nitrate was significantly greater in the nonincised, urbanizing stream (p Ecological engineering of stream corridors must focus at least as much energy on mediating hydrologic

  20. Channel allocation and rate adaptation for relayed transmission over correlated fading channels

    KAUST Repository

    Hwang, Kyusung

    2009-09-01

    We consider, in this paper, channel allocation and rate adaptation scheme for relayed transmission over correlated fading channels via cross-layer design. Specifically, jointly considering the data link layer buffer occupancy and channel quality at both the source and relay nodes, we develop an optimal channel allocation and rate adaptation policy for a dual-hop relayed transmission. As such the overall transmit power for the relayed system is minimized while a target packet dropping rate (PDR) due to buffer over flows is guaranteed. In order to find such an optimal policy, the channel allocation and rate adaptation transmission framework is formulated as a constraint Markov decision process (CMDP). The PDR performance of the optimal policy is compared with that of two conventional suboptimal schemes, namely the channel quality based and the buffer occupancy based channel allocation schemes. Numerical results show that for a given power budget, the optimal scheme requires significantly less power than the conventional schemes in order to maintain a target PDR. ©2009 IEEE.

  1. Mobile radio channels

    CERN Document Server

    Pätzold, Matthias

    2011-01-01

    Providing a comprehensive overview of the modelling, analysis and simulation of mobile radio channels, this book gives a detailed understanding of fundamental issues and examines state-of-the-art techniques in mobile radio channel modelling. It analyses several mobile fading channels, including terrestrial and satellite flat-fading channels, various types of wideband channels and advanced MIMO channels, providing a fundamental understanding of the issues currently being investigated in the field. Important classes of narrowband, wideband, and space-time wireless channels are explored in deta

  2. Towards a Dual Approach

    DEFF Research Database (Denmark)

    Holli, Anne Maria; Harder, Mette Marie Stæhr

    2016-01-01

    countries acknowledged as forerunners in gender equality, which also have ‘fairly strong’ parliamentary standing committees. The results show that both committees on gender equality can be regarded as ‘feminist’ in character and both interact with relevant civil society organisations. Their impact......Drawing on insights from state feminism and legislative studies on parliamentary committees, this article develops a dual approach for the comparative analysis of committees on gender equality. Empirically, it compares the standing committees on gender equality in Denmark and Finland, two Nordic...... as measured by legislative outputs and oversight differs, however, in line with differing committee system characteristics: the Finnish committee has more impact on legislative outputs while the Danish committee has more impact on overseeing government....

  3. Dual-horizon Peridynamics

    CERN Document Server

    Ren, Huilong; Cai, Yongchang; Rabczuk, Timon

    2015-01-01

    In this paper we develop a new Peridynamic approach that naturally includes varying horizon sizes and completely solves the "ghost force" issue. Therefore, the concept of dual-horizon is introduced to consider the unbalanced interactions between the particles with different horizon sizes. The present formulation is proved to fulfill both the balances of linear momentum and angular momentum. Neither the "partial stress tensor" nor the "`slice" technique are needed to ameliorate the ghost force issue in \\cite{Silling2014}. The consistency of reaction forces is naturally fulfilled by a unified simple formulation. The method can be easily implemented to any existing peridynamics code with minimal changes. A simple adaptive refinement procedure is proposed minimizing the computational cost. The method is applied here to the three Peridynamic formulations, namely bond based, ordinary state based and non-ordinary state based Peridynamics. Both two- and three- dimensional examples including the Kalthof-Winkler experi...

  4. Dual Criteria Decisions

    DEFF Research Database (Denmark)

    Andersen, Steffen; Harrison, Glenn W.; Lau, Morten Igel;

    2014-01-01

    The most popular models of decision making use a single criterion to evaluate projects or lotteries. However, decision makers may actually consider multiple criteria when evaluating projects. We consider a dual criteria model from psychology. This model integrates the familiar tradeoffs between...... risk and utility that economists traditionally assume, allowance for rank-dependent decision weights, and consideration of income thresholds. We examine the issues involved in full maximum likelihood estimation of the model using observed choice data. We propose a general method for integrating...... the multiple criteria, using the logic of mixture models, which we believe is attractive from a decision-theoretic and statistical perspective. The model is applied to observed choices from a major natural experiment involving intrinsically dynamic choices over highly skewed outcomes. The evidence points...

  5. X-ray focusing using microchannel plates

    Science.gov (United States)

    Kaaret, P.; Geissbuehler, P.; Chen, A.; Glavinas, E.

    1992-01-01

    We present measurements of the X-ray focusing properties of square-pore microchannel plates (MCP's). Square-pore MCP's contain large numbers of closely packed optical surfaces, as required for grazing incidence X-ray optics. The surface of individual MCP channels has been measured and found to have high microroughness transverse to the channel axis and low microroughness parallel to the axis. The high frequency transverse roughness, on length scales greater than 400 nm, has a rms value of 5.9 nm and a Gaussian autocorrelation function with correlation length of 1.41 micron. We find that the geometric misalignments of the surfaces of different channels limit the angular resolution obtainable with current samples of MCP's to 7.1 arcmin.

  6. Channel nut tool

    Energy Technology Data Exchange (ETDEWEB)

    Olson, Marvin

    2016-01-12

    A method, system, and apparatus for installing channel nuts includes a shank, a handle formed on a first end of a shank, and an end piece with a threaded shaft configured to receive a channel nut formed on the second end of the shaft. The tool can be used to insert or remove a channel nut in a channel framing system and then removed from the channel nut.

  7. Design of dual ring wavelength filters for WDM applications

    Science.gov (United States)

    Sathyadevaki, R.; Shanmuga sundar, D.; Sivanantha Raja, A.

    2016-12-01

    Wavelength division multiplexing plays a prime role in an optical communication due to its advantages such as easy network expansion, longer span lengths etc. In this work, photonic crystal based filters with the dual rings are proposed which act as band pass filters (BPF) and channel drop filter (CDF) that has found a massive applications in C and L-bands used for wavelength selection and noise filtering at erbium doped fiber amplifiers and dense wavelength division multiplexing operation. These filters are formulated on the square lattice with crystal rods of silicon material of refractive index 3.4 which are perforated on an air of refractive index 1. Dual ring double filters (band pass filter and channel drop filter) on single layout possess passing and dropping band of wavelengths in two distinct arrangements with entire band quality factors of 92.09523 & 505.263 and 124.85019 & 456.8633 for the pass and drop filters of initial setup and amended setup respectively. These filters have the high-quality factor with broad and narrow bandwidths of 16.8 nm & 3.04 nm and 12.85 nm & 3.3927 nm. Transmission spectra and band gap of the desired filters is analyzed using Optiwave software suite. Two dual ring filters incorporated on a single layout comprises the size of 15×11 μm which can also be used in the integrated photonic chips for the ultra-compact unification of devices.

  8. Development of dual-band barrier detectors

    Science.gov (United States)

    Plis, Elena; Myers, Stephen A.; Ramirez, David A.; Krishna, Sanjay

    2016-05-01

    We report on the development of dual-band InAs/GaSb type-II strained layer superlattices (T2SL) detectors with barrier designs at SK Infrared. Over the past five years, we demonstrated mid-wave/long-wave (MW/LWIR, cut-off wavelengths are 5 μm and 10.0 μm), and LW/LWIR (cut-off wavelengths are 9 μm and 11.0 μm) detectors with nBn and pBp designs. Recent results include a high performance bias-selectable long/long-wavelength infrared photodetector based on T2SL with a pBp barrier architecture. The two channels 50% cut-off wavelengths were ~ 9.2 μm and ~ 12 μm at 77 K. The "blue" and "red" LWIR absorbers demonstrated saturated QE values of 34 % and 28 %, respectively, measured in a backside illuminated configuration with a ~ 35 μm thick layer of residual GaSb substrate. Bulk-limited dark current levels were ~ 2.6 x 10-7 A/cm2 at + 100 mV and ~ 8.3 x 10-4 A/cm2 at - 200 mV for the "blue" and "red" channels, respectively.

  9. Dual diaphragm tank with telltale drain

    Science.gov (United States)

    Tuthill, Wallace C., Jr. (Inventor)

    1991-01-01

    A fluid storage and expulsion system comprising a tank with an internal flexible diaphragm assembly of dual diaphragms in back-to-back relationship, at least one of which is provided with a patterned surface having fine edges such that the diaphragms are in contact along said edges without mating contact of surface areas to thereby form fluid channels which extend outwardly to the peripheral edges of the diaphragms is described. The interior wall of the tank at the juncture of tank sections is formed with a circumferential annular recess comprising an outer annular recess portion which forms a fluid collection chamber and an inner annular recess portion which accommodates the peripheral edge portions of the diaphragms and a sealing ring in clamped sealing relation therebetween. The sealing ring is perforated with radially extending passages which allow any fluid leaking or diffusing past a diaphragm to flow through the fluid channels between the diaphragms to the fluid collection chamber. Ports connectable to pressure fittings are provided in the tank sections for admission of fluids to opposite sides of the diaphragm assembly. A drain passage through the tank wall to the fluid collection chamber permits detection, analysis and removal of fluids in the collection chamber.

  10. Focusing on Public Concerns

    Institute of Scientific and Technical Information of China (English)

    YAO BIN

    2010-01-01

    @@ The "people's livelihoods" was one of the most discussed topics inside and outside the annual full sessions of China's top legislature and advisory body earlier this month. In addition to lawmakers of the National People's Congress (NPC) and members of the National Committee of the Chinese People's Political Consultative Conference (CPPCC), ordinary people used various channels to express expectations for better handling of issues related to the people's livelihoods by the government.

  11. Dual of QCD with One Adjoint Fermion

    DEFF Research Database (Denmark)

    Mojaza, Matin; Nardecchia, Marco; Pica, Claudio;

    2011-01-01

    We construct the magnetic dual of QCD with one adjoint Weyl fermion. The dual is a consistent solution of the 't Hooft anomaly matching conditions, allows for flavor decoupling and remarkably constitutes the first nonsupersymmetric dual valid for any number of colors. The dual allows to bound the...

  12. Focused ultrasound in ophthalmology

    Directory of Open Access Journals (Sweden)

    Silverman RH

    2016-09-01

    Full Text Available Ronald H Silverman1,2 1Department of Ophthalmology, Columbia University Medical Center, 2F.L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, NY, USA Abstract: The use of focused ultrasound to obtain diagnostically significant information about the eye goes back to the 1950s. This review describes the historical and technological development of ophthalmic ultrasound and its clinical application and impact. Ultrasound, like light, can be focused, which is crucial for formation of high-resolution, diagnostically useful images. Focused, single-element, mechanically scanned transducers are most common in ophthalmology. Specially designed transducers have been used to generate focused, high-intensity ultrasound that through thermal effects has been used to treat glaucoma (via cilio-destruction, tumors, and other pathologies. Linear and annular transducer arrays offer synthetic focusing in which precise timing of the excitation of independently addressable array elements allows formation of a converging wavefront to create a focus at one or more programmable depths. Most recently, linear array-based plane-wave ultrasound, in which the array emits an unfocused wavefront and focusing is performed solely on received data, has been demonstrated for imaging ocular anatomy and blood flow. While the history of ophthalmic ultrasound extends back over half-a-century, new and powerful technologic advances continue to be made, offering the prospect of novel diagnostic capabilities. Keywords: ophthalmic ultrasound, ultrasound biomicroscopy (UBM, high-intensity focused ultrasound (HIFU, ultrafast imaging, Doppler imaging 

  13. FOCUS: Sustainable Mathematics Successes

    Science.gov (United States)

    Mireles, Selina V.; Acee, Taylor W.; Gerber, Lindsey N.

    2014-01-01

    The FOCUS (Fundamentals of Conceptual Understanding and Success) Co-Requisite Model Intervention (FOCUS Intervention) for College Algebra was developed as part of the Developmental Education Demonstration Projects (DEDP) in Texas. The program was designed to use multiple services, courses, and best practices to support student completion of a…

  14. Planar-Focusing Cathodes

    CERN Document Server

    Lewellen, J W

    2005-01-01

    Conventional pi-mode rf photoinjectors typically use magnetic solenoids for emittance compensation. This provides independent focusing strength, but can complicate rf power feed placement, introduce asymmetries (due to coil crossovers), and greatly increase the cost of the photoinjector. Cathode-region focusing can also provide for a form of emittance compensation. Typically this method strongly couples focusing strength to the field gradient on the cathode, however, and also requires altering the longitudinal position of the cathode to change the focusing. We propose a new method for achieving cathode-region variable-strength focusing for emittance compensation. The new method reduces the coupling to the gradient on the cathode, and does not require a change in the longitudinal position of the cathode. Expected performance for an S-band system is similar to conventional solenoid-based designs. This paper presents the results of rf cavity and beam dynamics simulations of the new design.

  15. Spin Testing of Superalloy Disks With Dual Grain Structure

    Science.gov (United States)

    Hefferman, Tab M.

    2006-01-01

    This 24-month program was a joint effort between Allison Advanced Development Company (AADC), General Electric Aircraft (GEAE), and NASA Glenn Research Center (GRC). AADC led the disk and spin hardware design and analysis utilizing existing Rolls-Royce turbine disk forging tooling. Testing focused on spin testing four disks: two supplied by GEAE and two by AADC. The two AADC disks were made of Alloy 10, and each was subjected to a different heat treat process: one producing dual microstructure with coarse grain size at the rim and fine grain size at the bore and the other produced single fine grain structure throughout. The purpose of the spin tests was to provide data for evaluation of the impact of dual grain structure on disk overspeed integrity (yielding) and rotor burst criteria. The program culminated with analysis and correlation of the data to current rotor overspeed criteria and advanced criteria required for dual structure disks.

  16. Multi-Channel Retailing

    Directory of Open Access Journals (Sweden)

    Dirk Morschett, Dr.,

    2005-01-01

    Full Text Available Multi-channel retailing entails the parallel use by retailing enterprises of several sales channels. The results of an online buyer survey which has been conducted to investigate the impact of multi-channel retailing (i.e. the use of several retail channels by one retail company on consumer behaviour show that the frequently expressed concern that the application of multi-channel systems in retailing would be associated with cannibalization effects, has proven unfounded. Indeed, the appropriate degree of similarity, consistency, integration and agreement achieves the exact opposite. Different channels create different advantages for consumers. Therefore the total benefit an enterprise which has a multi-channel system can offer to its consumers is larger, the greater the number of available channels. The use of multi-channel systems is associated with additional purchases in the different channels. Such systems are thus superior to those offering only one sales channel to their customers. Furthermore, multi-channel systems with integrated channels are superior to those in which the channels are essentially autonomous and independent of one another. In integrated systems, consumers can achieve synergy effects in the use of sales-channel systems. Accordingly, when appropriately formulated, multi-channel systems in retailing impact positively on consumers. They use the channels more frequently, buy more from them and there is a positive customer-loyalty impact. Multi-channel systems are strategic options for achieving customer loyalty, exploiting customer potential and for winning new customers. They are thus well suited for approaching differing and varied target groups.

  17. The Man of Dual Nationality.

    Science.gov (United States)

    Abe, Yoshio

    1985-01-01

    Presents an English translation of the first few pages, set in a Japanese internment camp in the U.S. during World War II, of a Japanese novel about the problems of dual nationality and personal identity. (KH)

  18. Assimilation of Dual-Polarimetric Radar Observations with WRF GSI

    Science.gov (United States)

    Li, Xuanli; Mecikalski, John; Fehnel, Traci; Zavodsky, Bradley; Srikishen, Jayanthi

    2014-01-01

    Dual-polarimetric (dual-pol) radar typically transmits both horizontally and vertically polarized radio wave pulses. From the two different reflected power returns, more accurate estimate of liquid and solid cloud and precipitation can be provided. The upgrade of the traditional NWS WSR-88D radar to include dual-pol capabilities will soon be completed for the entire NEXRAD network. Therefore, the use of dual-pol radar network will have a broad impact in both research and operational communities. The assimilation of dual-pol radar data is especially challenging as few guidelines have been provided by previous research. It is our goal to examine how to best use dual-pol radar data to improve forecast of severe storm and forecast initialization. In recent years, the Development Testbed Center (DTC) has released the community Gridpoint Statistical Interpolation (GSI) DA system for the Weather Research and Forecasting (WRF) model. The community GSI system runs in independently environment, yet works functionally equivalent to operational centers. With collaboration with the NASA Short-term Prediction Research and Transition (SPoRT) Center, this study explores regional assimilation of the dual-pol radar variables from the WSR-88D radars for real case storms. Our presentation will highlight our recent effort on incorporating the horizontal reflectivity (ZH), differential reflectivity (ZDR), specific differential phase (KDP), and radial velocity (VR) data for initializing convective storms, with a significant focus being on an improved representation of hydrometeor fields. In addition, discussion will be provided on the development of enhanced assimilation procedures in the GSI system with respect to dual-pol variables. Beyond the dual-pol variable assimilation procedure developing within a GSI framework, highresolution (=1 km) WRF model simulations and storm scale data assimilation experiments will be examined, emphasizing both model initialization and short-term forecast

  19. Large format voltage tunable dual-band QWIP FPAs

    Science.gov (United States)

    Arslan, Y.; Eker, S. U.; Kaldirim, M.; Besikci, C.

    2009-11-01

    Third generation thermal imagers with dual/multi-band operation capability are the prominent focus of the current research in the field of infrared detection. Dual band quantum-well infrared photodetector (QWIP) focal plane arrays (FPAs) based on various detection and fabrication approaches have been reported. One of these approaches is the three-contact design allowing simultaneous integration of the signals in both bands. However, this approach requires three In bumps on each pixel leading to a complicated fabrication process and lower fill factor. If the spectral response of a two-stack QWIP structure can effectively be shifted between two spectral bands with the applied bias, dual band sensors can be implemented with the conventional FPA fabrication process requiring only one In bump on each pixel making it possible to fabricate large format dual band FPAs at the cost and yield of single band detectors. While some disadvantages of this technique have been discussed in the literature, the detailed assessment of this approach has not been performed at the FPA level yet. We report the characteristics of a large format (640 × 512) voltage tunable dual-band QWIP FPA constructed through series connection of MWIR AlGaAs-InGaAs and LWIR AlGaAs-GaAs multi-quantum well stacks, and provide a detailed assessment of the potential of this approach at both pixel and FPA levels. The dual band FPA having MWIR and LWIR cut-off wavelengths of 5.1 and 8.9 μm provided noise equivalent temperature differences as low as 14 and 31 mK ( f/1.5) with switching voltages within the limits applicable by commercial read-out integrated circuits. The results demonstrate the promise of the approach for achieving large format low cost dual band FPAs.

  20. First-Order Acoustic Wave Equation Reverse Time Migration Based on the Dual-Sensor Seismic Acquisition System

    Science.gov (United States)

    You, Jiachun; Liu, Xuewei; Wu, Ru-Shan

    2017-03-01

    We analyze the mathematical requirements for conventional reverse time migration (RTM) and summarize their rationale. The known information provided by current acquisition system is inadequate for the second-order acoustic wave equations. Therefore, we introduce a dual-sensor seismic acquisition system into the coupled first-order acoustic wave equations. We propose a new dual-sensor reverse time migration called dual-sensor RTM, which includes two input variables, the pressure and vertical particle velocity data. We focus on the performance of dual-sensor RTM in estimating reflection coefficients compared with conventional RTM. Synthetic examples are used for the study of estimating coefficients of reflectors with both dual-sensor RTM and conventional RTM. The results indicate that dual-sensor RTM with two inputs calculates amplitude information more accurately and images structural positions of complex substructures, such as the Marmousi model, more clearly than that of conventional RTM. This shows that the dual-sensor RTM has better accuracy in backpropagation and carries more information in the directivity because of particle velocity injection. Through a simple point-shape model, we demonstrate that dual-sensor RTM decreases the effect of multi-pathing of propagating waves, which is helpful for focusing the energy. In addition, compared to conventional RTM, dual-sensor RTM does not cause extra memory costs. Dual-sensor RTM is, therefore, promising for the computation of multi-component seismic data.

  1. Perfect Multi-Channel Flat Reflectors

    CERN Document Server

    Asadchy, V S; Elsakka, A; Albooyeh, M; Tretyakov, S A

    2016-01-01

    Recent advances in engineered gradient metasurfaces have enabled unprecedented opportunities for light manipulation using optically thin sheets, such as anomalous refraction, reflection, or focusing of an incident beam. Here we introduce a concept of multi-channel functional metasurfaces, which are able to control incoming and outgoing waves in a number of propagation directions or polarization states simultaneously and independently. In particular, we reveal a possibility to create perfect multi-channel reflectors. Under the assumption of reciprocity and energy conservation, we find that there exist three fundamental classes of multi-channel mirrors. Together they form a basis of all possible reflection functionalities achievable with flat periodically modulated reflectors. To demonstrate the potential of the introduced concept, we design and experimentally test one of the basis multi-channel reflectors, confirming the desired multi-channel response. Furthermore, by extending the concept to reflectors suppor...

  2. DESIGN OF A DUAL KEYBOARD

    OpenAIRE

    V. Ragavi; G. Geetha

    2013-01-01

    The design of a computer keyboard with dual function is proposed. This computer keyboard called Dual Keyboard can function both as a normal keyboard and as a pressure sensitive keyboard. The proposed device has a switch that decides the function. The keyboard makes use of sensors placed beneath the keys to measure the pressure applied on the key by the user. This device has many applications. In this study, it is applied to mitigate Denial of Service (DoS) attack.

  3. Dual pairs in fluid dynamics

    CERN Document Server

    Gay-Balmaz, François

    2010-01-01

    This paper is a rigorous study of the dual pair structure of the ideal fluid and the dual pair structure for the $n$-dimensional Camassa-Holm (EPDiff) equation, including the proofs of the necessary transitivity results. In the case of the ideal fluid, we show that a careful definition of the momentum maps leads naturally to central extensions of diffeomorphism groups such as the group of quantomorphisms and the Ismagilov central extension.

  4. Lp-dual Quermassintegral sums

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper,we first introduce a concept of L_p-dual Quermassintegral sum function of convex bodies and establish the polar projection Minkowski inequality and the polar projection Aleksandrov-Fenchel inequality for L_p-dual Quermassintegral sums.Moreover,by using Lutwak’s width-integral of index i,we establish the L_p-Brunn-Minkowski inequality for the polar mixed projec- tion bodies.As applications,we prove some interrelated results.

  5. Cooperative communications hardware, channel and PHY

    CERN Document Server

    Dohler, Mischa

    2010-01-01

    Facilitating Cooperation for Wireless Systems Cooperative Communications: Hardware, Channel & PHY focuses on issues pertaining to the PHY layer of wireless communication networks, offering a rigorous taxonomy of this dispersed field, along with a range of application scenarios for cooperative and distributed schemes, demonstrating how these techniques can be employed. The authors discuss hardware, complexity and power consumption issues, which are vital for understanding what can be realized at the PHY layer, showing how wireless channel models differ from more traditional

  6. Sublattice dependent magnetic response of dual Cr doped graphene monolayer: a full potential approach

    Science.gov (United States)

    Thakur, Jyoti; Kashyap, Manish K.; Taya, Ankur; Rani, Priti; Saini, Hardev S.

    2017-01-01

    In the present scenario, many researchers are exploring the possibility of inducing a magnetic channel in graphene by introducing various types of defects. To examine the Cr-Cr interactions in dual Cr doped graphene monolayer for magnetic response and spin polarization, the first-principles density functional theory based calculations are performed. Further, the possibility of achieving 100 % spin polarization in various possible configurations of dual Cr-doping have been explored. Dual doping of Cr atoms in graphene monolayer preferring ferromagnetic ordering, generates a spin magnetic state with a local moment of 4.00 µB. Depending upon the relative position of two Cr impurities in graphene, the ground states of doped systems are found be ferromagnetic, antiferromagnetic or paramagnetic. The origin of particular magnetic state observed in all possible dual Cr-doping configurations has been explained on the basis of RKKY indirect exchange interactions.

  7. Homogeneous M2 duals

    CERN Document Server

    Figueroa-O'Farrill, José

    2015-01-01

    Motivated by the search for new gravity duals to M2 branes with $N>4$ supersymmetry --- equivalently, M-theory backgrounds with Killing superalgebra $\\mathfrak{osp}(N|4)$ for $N>4$ --- we classify (except for a small gap) homogeneous M-theory backgrounds with symmetry Lie algebra $\\mathfrak{so}(n) \\oplus \\mathfrak{so}(3,2)$ for $n=5,6,7$. We find that there are no new backgrounds with $n=6,7$ but we do find a number of new (to us) backgrounds with $n=5$. All backgrounds are metrically products of the form $\\operatorname{AdS}_4 \\times P^7$, with $P$ riemannian and homogeneous under the action of $\\operatorname{SO}(5)$, or $S^4 \\times Q^7$ with $Q$ lorentzian and homogeneous under the action of $\\operatorname{SO}(3,2)$. At least one of the new backgrounds is supersymmetric (albeit with only $N=2$) and we show that it can be constructed from a supersymmetric Freund--Rubin background via a Wick rotation. Two of the new backgrounds have only been approximated numerically.

  8. Fast dual tomography

    Science.gov (United States)

    Carrion, Philip M.

    1990-09-01

    This paper can be considered as a continuation of the work by Carrion and Carneiro (1989), where a generalized approach to linearized inversion of geophysical data was developed. Their method allows one to incorporate virtually any constraints in the inversion and reformulate the problem in the dual space of Langrangian multipliers (see also Carrion, 1989a). The constrained tomography makes traveltime inversion robust: it automatically rejects “bad data” which correspond to solutions beyond the chosen constraints and allows one to start inversion with an arbitrary chosen initial model.In this paper, I will derive basic formulas for constrained tomographic imaging that can be used in such areas of geophysics as global mapping of the earth interior, exploration geophysics, etc. The method is fast: an example that will be shown in the paper took only 6 min. of VAX CPU time. Had the conventional least-squares matrix inversion been used it would have taken more than 10 hours of the CPU time to solve the same problem.

  9. Fast dual tomography

    Energy Technology Data Exchange (ETDEWEB)

    Carrion, P.M. (PPPG/UFBA - Campus Universitario da Federacao, Salvador-Bahia (Brazil))

    1990-09-01

    This paper can be considered as a continuation of the work by Carrion and Carneiro (1989), where a generalized approach to linearized inversion of geophysical data was developed. Their method allows one to incorporate virtually any constraints in the inversion and reformulate the problem in the dual space of Langrangian multipliers (see also Carrion, 1989a). The constrained tomography makes traveltime inversion robust: it automatically rejects bad data which correspond to solutions beyond the chosen constraints and allows one to start inversion with an arbitrary chosen initial model. In this paper, the author derives basic formulas for constrained tomographic imaging that can be used in such areas of geophysics as global mapping of the earth interior, exploration geophysics, etc. The method is fast: an example that will be shown in the paper took only 6 min. of VAX CPU time. Had the conventional least-squares matrix inversion been used it would have taken more than 10 hours of the CPU time to solve the same problem.

  10. New focused crawling algorithm

    Institute of Scientific and Technical Information of China (English)

    Su Guiyang; Li Jianhua; Ma Yinghua; Li Shenghong; Song Juping

    2005-01-01

    Focused carawling is a new research approach of search engine. It restricts information retrieval and provides search service in specific topic area. Focused crawling search algorithm is a key technique of focused crawler which directly affects the search quality. This paper first introduces several traditional topic-specific crawling algorithms, then an inverse link based topic-specific crawling algorithm is put forward. Comparison experiment proves that this algorithm has a good performance in recall, obviously better than traditional Breadth-First and Shark-Search algorithms. The experiment also proves that this algorithm has a good precision.

  11. Dual Heat Pulse, Dual Layer Thermal Protection System Sizing Analysis and Trade Studies for Human Mars Entry Descent and Landing

    Science.gov (United States)

    McGuire, Mary Kathleen

    2011-01-01

    NASA has been recently updating design reference missions for the human exploration of Mars and evaluating the technology investments required to do so. The first of these started in January 2007 and developed the Mars Design Reference Architecture 5.0 (DRA5). As part of DRA5, Thermal Protection System (TPS) sizing analysis was performed on a mid L/D rigid aeroshell undergoing a dual heat pulse (aerocapture and atmospheric entry) trajectory. The DRA5 TPS subteam determined that using traditional monolithic ablator systems would be mass expensive. They proposed a new dual-layer TPS concept utilizing an ablator atop a low thermal conductivity insulative substrate to address the issue. Using existing thermal response models for an ablator and insulative tile, preliminary hand analysis of the dual layer concept at a few key heating points indicated that the concept showed potential to reduce TPS masses and warranted further study. In FY09, the followon Entry, Descent and Landing Systems Analysis (EDL-SA) project continued by focusing on Exploration-class cargo or crewed missions requiring 10 to 50 metric tons of landed payload. The TPS subteam advanced the preliminary dual-layer TPS analysis by developing a new process and updated TPS sizing code to rapidly evaluate mass-optimized, full body sizing for a dual layer TPS that is capable of dual heat pulse performance. This paper describes the process and presents the results of the EDL-SA FY09 dual-layer TPS analyses on the rigid mid L/D aeroshell. Additionally, several trade studies were conducted with the sizing code to evaluate the impact of various design factors, assumptions and margins.

  12. Synchronization of P Systems with Simplex Channels

    CERN Document Server

    Ipate, Florentin; Niculescu, Ionut-Mihai; Stefan, Cristian

    2011-01-01

    We solve the Firing Squad Synchronization Problem (FSSP), for P systems based on digraphs with simplex channels, where communication is restricted by the direction of structural arcs. Previous work on FSSP for P systems focused exclusively on P systems with duplex channels, where communication between parents and children is bidirectional. Our P solution, the first for simplex channels, requires cell IDs, strongly connected digraphs and some awareness of the local topology (such as each cell's outdegree)---we argue that these requirements are necessary. Compared to the known solutions for cellular automata, our solution is substantially simpler and faster.

  13. Operator-sum representation for bosonic Gaussian channels

    Energy Technology Data Exchange (ETDEWEB)

    Ivan, J. Solomon; Sabapathy, Krishna Kumar; Simon, R. [Raman Research Institute, C. V. Raman Avenue, Sadashivanagar, Bangalore 560 080 (India); Optics and Quantum Information Group, The Institute of Mathematical Sciences, C.I.T. Campus, Tharamani, Chennai 600 113 (India)

    2011-10-15

    Operator-sum or Kraus representations for single-mode bosonic Gaussian channels are developed, and several of their consequences explored. The fact that the two-mode metaplectic operators acting as unitary purification of these channels do not, in their canonical form, mix the position and momentum variables is exploited to present a procedure which applies uniformly to all families in the Holevo classification. In this procedure the Kraus operators of every quantum-limited Gaussian channel can be simply read off from the matrix elements of a corresponding metaplectic operator. Kraus operators are employed to bring out, in the Fock basis, the manner in which the antilinear, unphysical matrix transposition map when accompanied by injection of a threshold classical noise becomes a physical channel, denoted D({kappa}) in the Holevo classification. The matrix transposition channels D({kappa}), D({kappa}{sup -1}) turn out to be a dual pair in the sense that their Kraus operators are related by the adjoint operation. The amplifier channel with amplification factor {kappa} and the beam-splitter channel with attenuation factor {kappa}{sup -1} turn out to be mutually dual in the same sense. The action of the quantum-limited attenuator and amplifier channels as simply scaling maps on suitable quasiprobabilities in phase space is examined in the Kraus picture. Consideration of cumulants is used to examine the issue of fixed points. The semigroup property of the amplifier and attenuator families leads in both cases to a Zeno-like effect arising as a consequence of interrupted evolution. In the cases of entanglement-breaking channels a description in terms of rank 1 Kraus operators is shown to emerge quite simply. In contradistinction, it is shown that there is not even one finite rank operator in the entire linear span of Kraus operators of the quantum-limited amplifier or attenuator families, an assertion far stronger than the statement that these are not entanglement

  14. Analytical Modeling of Electric Field Distribution in Dual Material Junctionless Surrounding Gate MOSFETs

    Directory of Open Access Journals (Sweden)

    P. Suveetha Dhanaselvam

    2014-10-01

    Full Text Available In this paper, electric field distribution of the junctionless dual material surrounding gate MOSFETs (JLDMSG is developed. Junctionless is a device that has similar characteristics like junction based devices, but junctionless has a positive flatband voltage with zero electric field. In Surrounding gate MOSFETs gate material surrounds the channel in all direction , therefore it can overcome the short channel effects effectively than other devices. In this paper, surface potential and electric field distribution is modelled. The proposed surface potential model is compared with the existing central potential model. It is observed that the short channel effects (SCE is reduced and the performance is better than the existing method.

  15. Final focus test beam

    Energy Technology Data Exchange (ETDEWEB)

    1991-03-01

    This report discusses the following: the Final Focus Test Beam Project; optical design; magnets; instrumentation; magnetic measurement and BPM calibration; mechanical alignment and stabilization; vacuum system; power supplies; control system; radiation shielding and personnel protection; infrastructure; and administration.

  16. Final focus nomenclature

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, R.

    1986-08-08

    The formal names and common names for all devices in the final focus system of the SLC are listed. The formal names consist of a device type designator, microprocessor designator, and a four-digit unit number. (LEW)

  17. Focus group discussions

    CERN Document Server

    Hennink, Monique M

    2014-01-01

    The Understanding Research series focuses on the process of writing up social research. The series is broken down into three categories: Understanding Statistics, Understanding Measurement, and Understanding Qualitative Research. The books provide researchers with guides to understanding, writing, and evaluating social research. Each volume demonstrates how research should be represented, including how to write up the methodology as well as the research findings. Each volume also reviews how to appropriately evaluate published research. Focus Group Discussions addresses the challenges associated with conducting and writing focus group research. It provides detailed guidance on the practical and theoretical considerations in conducting focus group discussions including: designing the discussion guide, recruiting participants, training a field team, moderating techniques and ethical considerations. Monique Hennink describes how a methodology section is read and evaluated by others, such as journal reviewers or ...

  18. Mapping out the customer’s journey : customer search strategy as a basis for channel management

    NARCIS (Netherlands)

    Veen, Gerrita van der; Ossenbruggen, Robert van

    2015-01-01

    Many companies tailor their communication and interaction with customers by segmenting them into channel usage groups. This study argues that simply focusing on channels has limited effectiveness as increasingly customers today use multiple channels, the online channel contains many different forms,

  19. High harmonics focusing undulator

    Energy Technology Data Exchange (ETDEWEB)

    Varfolomeev, A.A.; Hairetdinov, A.H.; Smirnov, A.V.; Khlebnikov, A.S. [Kurchatov Institute, Moscow (Russian Federation)

    1995-12-31

    It was shown in our previous work that there exist a possibility to enhance significantly the {open_quote}natural{close_quote} focusing properties of the hybrid undulator. Here we analyze the actual undulator configurations which could provide such field structure. Numerical simulations using 2D code PANDIRA were carried out and the enhanced focusing properties of the undulator were demonstrated. The obtained results provide the solution for the beam transport in a very long (short wavelength) undulator schemes.

  20. CLIC Final Focus Studies

    CERN Document Server

    Tomás, R; Schulte, Daniel; Zimmermann, Frank

    2006-01-01

    The CLIC final focus system has been designed based on the local compensation scheme proposed by P. Raimondi and A. Seryi. However, there exist important chromatic aberrations that deteriorate the performance of the system. This paper studies the optimization of the final focus based on the computation of the higher orders of the map using MAD-X and PTC. The use of octupole tail folding to reduce the size of the halo in the locations with aperture limitations is also discussed.

  1. Electron beam focusing system

    Energy Technology Data Exchange (ETDEWEB)

    Dikansky, N.; Nagaitsev, S.; Parkhomchuk, V.

    1997-09-01

    The high energy electron cooling requires a very cold electron beam. Thus, the electron beam focusing system is very important for the performance of electron cooling. A system with and without longitudinal magnetic field is presented for discussion. Interaction of electron beam with the vacuum chamber as well as with the background ions and stored antiprotons can cause the coherent electron beam instabilities. Focusing system requirements needed to suppress these instabilities are presented.

  2. USACE Navigation Channels 2012

    Data.gov (United States)

    California Department of Resources — This dataset represents both San Francisco and Los Angeles District navigation channel lines. All San Francisco District channel lines were digitized from CAD files...

  3. Plutonium focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  4. A Micromechanical RF Channelizer

    Science.gov (United States)

    Akgul, Mehmet

    The power consumption of a radio generally goes as the number and strength of the RF signals it must process. In particular, a radio receiver would consume much less power if the signal presented to its electronics contained only the desired signal in a tiny percent bandwidth frequency channel, rather than the typical mix of signals containing unwanted energy outside the desired channel. Unfortunately, a lack of filters capable of selecting single channel bandwidths at RF forces the front-ends of contemporary receivers to accept unwanted signals, and thus, to operate with sub-optimal efficiency. This dissertation focuses on the degree to which capacitive-gap transduced micromechanical resonators can achieve the aforementioned RF channel-selecting filters. It aims to first show theoretically that with appropriate scaling capacitive-gap transducers are strong enough to meet the needed coupling requirements; and second, to fully detail an architecture and design procedure needed to realize said filters. Finally, this dissertation provides an actual experimentally demonstrated RF channel-select filter designed using the developed procedures and confirming theoretical predictions. Specifically, this dissertation introduces four methods that make possible the design and fabrication of RF channel-select filters. The first of these introduces a small-signal equivalent circuit for parallel-plate capacitive-gap transduced micromechanical resonators that employs negative capacitance to model the dependence of resonance frequency on electrical stiffness in a way that facilitates the analysis of micromechanical circuits loaded with arbitrary electrical impedances. The new circuit model not only correctly predicts the dependence of electrical stiffness on the impedances loading the input and output electrodes of parallel-plate capacitive-gap transduced micromechanical device, but does so in a visually intuitive way that identifies current drive as most appropriate for

  5. KV7 potassium channels

    DEFF Research Database (Denmark)

    Stott, Jennifer B; Jepps, Thomas Andrew; Greenwood, Iain A

    2014-01-01

    Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been...

  6. Quantum Multiple Access Channel

    Institute of Scientific and Technical Information of China (English)

    侯广; 黄民信; 张永德

    2002-01-01

    We consider the transmission of classical information over a quantum channel by many senders, which is a generalization of the two-sender case. The channel capacity region is shown to be a convex hull bound by the yon Neumann entropy and the conditional yon Neumann entropies. The result allows a reasonable distribution of channel capacity over the senders.

  7. Cardiac potassium channel subtypes

    DEFF Research Database (Denmark)

    Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter

    2014-01-01

    About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K(+) channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the cardiac cycle. Three main K(+) channels...

  8. A 32-channel waveform sampling FASTBUS module with local DSP processing

    Energy Technology Data Exchange (ETDEWEB)

    Wixted, R.L. [Princeton Univ., NJ (United States). Dept. of Physics; Chidzik, S. [Princeton Univ., NJ (United States). Dept. of Physics; Marlow, D.R. [Princeton Univ., NJ (United States). Dept. of Physics; Mindas, C.R. [Princeton Univ., NJ (United States). Dept. of Physics; Sekikawa, S. [Institute of Physics, University of Tsukuba, Tsukuba, Ibaraki 305 (Japan); Arai, I. [Institute of Physics, University of Tsukuba, Tsukuba, Ibaraki 305 (Japan); Suzuki, A. [Institute of Physics, University of Tsukuba, Tsukuba, Ibaraki 305 (Japan); Watanabe, A. [Institute of Physics, University of Tsukuba, Tsukuba, Ibaraki 305 (Japan); Kuno, Y. [Department of Physics, National Laboratory for High Energy Physics (KEK), Tsukuba, Ibaraki 305 (Japan)

    1997-02-21

    A 32-channel FASTBUS module that uses switched-capacitor arrays to sample and store input waveforms at rates up to 30 MHz is described. The captured data are digitized using commercial 12-bit analog-to-digital converters and are routed to an array of dual port memories. The data in the dual port memories can be readout directly over the FASTBUS backplane or can be subjected to further processing by a digital signal processor mounted on the FASTBUS auxiliary card. (orig.).

  9. Calmodulin modulation of ion channels and receptors

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Ion channels and receptors are the structural basis for neural signaling and transmission. Recently, the function of ion channels and receptors has been demonstrated to be modulated by many intracellular and extracellular chemicals and signaling molecules. Increasing evidence indicates that the complexity and plasticity of the function of central nervous system is determined by the modulation of ion channels and receptors. Among various mechanisms, Ca 2+ signaling pathways play important roles in neuronal activity and some pathological changes. Ca 2+ influx through ion channels and receptors can modulate its further influx in a feedback way or modulate other ion channels and receptors. The common feature of the modulation is that Ca 2+ /calmodulin (CaM) is the universal mediator. CaM maintains the coordination among ion channels/receptors and intracellular Ca 2+ homeostasis by feedback modulation of ion channels/receptors activity. This review focuses on the modulating processes of ion channels and receptors mediated by CaM, and further elucidates the mechanisms of Ca 2+ signaling.

  10. Propagation channel characterization, parameter estimation, and modeling for wireless communications

    CERN Document Server

    Yin, Xuefeng

    2016-01-01

    Thoroughly covering channel characteristics and parameters, this book provides the knowledge needed to design various wireless systems, such as cellular communication systems, RFID and ad hoc wireless communication systems. It gives a detailed introduction to aspects of channels before presenting the novel estimation and modelling techniques which can be used to achieve accurate models. To systematically guide readers through the topic, the book is organised in three distinct parts. The first part covers the fundamentals of the characterization of propagation channels, including the conventional single-input single-output (SISO) propagation channel characterization as well as its extension to multiple-input multiple-output (MIMO) cases. Part two focuses on channel measurements and channel data post-processing. Wideband channel measurements are introduced, including the equipment, technology and advantages and disadvantages of different data acquisition schemes. The channel parameter estimation methods are ...

  11. Expansion coding: Achieving the capacity of an AEN channel

    CERN Document Server

    Koyluoglu, O Ozan; Si, Hongbo; Vishwanath, Sriram

    2012-01-01

    A general method of coding over expansions is proposed, which allows one to reduce the highly non-trivial problem of coding over continuous channels to a much simpler discrete ones. More specifically, the focus is on the additive exponential noise (AEN) channel, for which the (binary) expansion of the (exponential) noise random variable is considered. It is shown that each of the random variables in the expansion corresponds to independent Bernoulli random variables. Thus, each of the expansion levels (of the underlying channel) corresponds to a binary symmetric channel (BSC), and the coding problem is reduced to coding over these parallel channels while satisfying the channel input constraint. This optimization formulation is stated as the achievable rate result, for which a specific choice of input distribution is shown to achieve a rate which is arbitrarily close to the channel capacity in the high SNR regime. Remarkably, the scheme allows for low-complexity capacity-achieving codes for AEN channels, using...

  12. EDITORIAL: Focus on Plasmonics FOCUS ON PLASMONICS

    Science.gov (United States)

    Bozhevolnyi, Sergey; García-Vidal, Francisco

    2008-10-01

    Plasmonics is an emerging field in optics dealing with the so-called surface plasmons whose extraordinary properties are being both analyzed from a fundamental point of view and exploited for numerous technological applications. Surface plasmons associated with surface electron density oscillations decorating metal-dielectric interfaces were discovered by Rufus Ritchie in the 1950s. Since the seventies, the subwavelength confinement of electromagnetic fields as well as their enhancement inherent to the surface plasmon excitation has been widely used for spectroscopic purposes. Recent advances in nano-fabrication, characterization and modelling techniques have allowed unique properties of these surface electromagnetic modes to be explored with respect to subwavelength field localization and waveguiding, opening the path to truly nanoscale plasmonic optical devices. This area of investigation also has interesting links with research on photonic band gap materials and the field of optical metamaterials. Nowadays, plasmonics can be seen as a mature interdisciplinary area of research in which scientists coming from different backgrounds (chemistry, physics, optics and engineering) strive to discover and exploit new and exciting phenomena associated with surface plasmons. The already made and forthcoming discoveries will have impacts in many fields of science and technology, including not only photonics and materials science but also computation, biology and medicine, among others. This focus issue of New Journal of Physics is intended to cover all the aforementioned capabilities of surface plasmons by presenting a current overview of state-of-the-art advances achieved by the leading groups in this field of research. The below list of articles represents the first contributions to the collection and further additions will appear soon. Focus on Plasmonics Contents Nanoantenna array-induced fluorescence enhancement and reduced lifetimes Reuben M Bakker, Vladimir P Drachev

  13. A channel- and QoS-adaptive turbo coded modulation architecture for mobile multimedia communication

    Institute of Scientific and Technical Information of China (English)

    Zuo Jiancun; Song Wentao; Luo Hanwen; Xu Youyun

    2009-01-01

    This paper proposed a cross-layer dual adaptive coded modulation architecture using turbo codes for mobile multimedia communication, which simultaneously adapted to both the varying channel characteristics and the quality of service (QoS) of various mobile multimedia services to increase the average system throughput substantially. A pragmatic channel-adaptive turbo coded modulation scheme, which comes within 2.5dB of the Shannon limit, was optimally designed, and then a QoS-adaptive scheme was superimposed to build the dual adaptive architecture. Simulation results show that the novel dual adaption reduces the difference with the fading channel capacity to 2dB when assuming different services occur in equal probability and the service duration follows the exponential distribution.

  14. Characteristics of Si+/B+ dual implanted silicon wafers

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Thin p+ layers with good electrical properties were fabricated by RTA (rapid thermal annealing) with post-FA (furance annealing) of Si+/B+ dual implanted silicon wafers. The electrical and structural characteristics of thin p+ layers have been measured by FPP (four-point probe), SRP (spreading resistance probe), RBS/channelling. Optimizing the implantation and annealing processes, especially using the thermal cycle of RTA followed by FA, shallow p+n junctions can be fabricated, which shows excellent I-V characteristics with revers-bias leakage current densities of 1.8?nA/cm2 at -1.4?V.

  15. Wireless multi-antenna channels modeling and simulation

    CERN Document Server

    Primak, Serguei

    2011-01-01

    This book offers a practical guide on how to use and apply channel models for system evaluation In this book, the authors focus on modeling and simulation of multiple antennas channels, including multiple input multiple output (MIMO) communication channels, and the impact of such models on channel estimation and system performance. Both narrowband and wideband models are addressed. Furthermore, the book covers topics related to modeling of MIMO channel, their numerical simulation, estimation and prediction, as well as applications to receive diversity, capacity and space-time c

  16. Fiber and crystals dual readout calorimeters

    Science.gov (United States)

    Cascella, Michele; Franchino, Silvia; Lee, Sehwook

    2016-11-01

    The RD52 (DREAM) collaboration is performing R&D on dual readout calorimetry techniques with the aim of improving hadronic energy resolution for future high energy physics experiments. The simultaneous detection of Cherenkov and scintillation light enables us to measure the electromagnetic fraction of hadron shower event-by-event. As a result, we could eliminate the main fluctuation which prevented from achieving precision energy measurement for hadrons. We have tested the performance of the lead and copper fiber prototypes calorimeters with various energies of electromagnetic particles and hadrons. During the beam test, we investigated the energy resolutions for electrons and pions as well as the identification of those particles in a longitudinally unsegmented calorimeter. Measurements were also performed on pure and doped PbWO4 crystals, as well as BGO and BSO, with the aim of realizing a crystal based dual readout detector. We will describe our results, focusing on the more promising properties of homogeneous media for the technique. Guidelines for additional developments on crystals will be also given. Finally we discuss the construction techniques that we have used to assemble our prototypes and give an overview of the ones that could be industrialized for the construction of a full hermetic calorimeter.

  17. Decontamination & decommissioning focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  18. Doing focus group research

    DEFF Research Database (Denmark)

    Lindegaard, Laura Bang

    2014-01-01

    , not as something that pre-exists or goes beyond the situated interaction. This article, however, challenges not only the first, but also the second position and suggests that it is, after all, possible to do committedly ethnomethodological studies of focus group data that demonstrate how members of a focus group......Scholars of ethnomethodologically informed discourse studies are often sceptical of the use of interview data such as focus group data. Some scholars quite simply reject interview data with reference to a general preference for so-called naturally occurring data. Other scholars acknowledge...... of interview interaction, but inadequate as data for studying phenomena that go beyond the phenomenon of interview interaction. Neither of these more and less sceptical positions are, on the face of it, surprising due to the ethnomethodological commitment to study social order as accomplished in situ...

  19. Focusing Vacuum Fluctuations, 2

    CERN Document Server

    Ford, L H

    2002-01-01

    The quantization of the scalar and electromagnetic fields in the presence of a parabolic mirror is further developed in the context of a geometric optics approximation. We calculate the mean squared scalar and electric fields near the focal line of a parabolic cylindrical mirror. These quantities are found to grow as inverse powers of the distance from the focus. We give a combination of analytic and numerical results for the mean squared fields. In particular, we find that the mean squared electric field can be either negative or positive, depending upon the choice of parameters. The case of a negative mean squared electric field corresponds to a repulsive Van der Waals force on an atom near the focus, and to a region of negative energy density. Similarly, a positive value corresponds to an attractive force and a possibility of atom trapping in the vicinity of the focus.

  20. High throughput-per-footprint inertial focusing.

    Science.gov (United States)

    Ciftlik, Ata Tuna; Ettori, Maxime; Gijs, Martin A M

    2013-08-26

    Matching the scale of microfluidic flow systems with that of microelectronic chips for realizing monolithically integrated systems still needs to be accomplished. However, this is appealing only if such re-scaling does not compromise the fluidic throughput. This is related to the fact that the cost of microelectronic circuits primarily depends on the layout footprint, while the performance of many microfluidic systems, like flow cytometers, is measured by the throughput. The simple operation of inertial particle focusing makes it a promising technique for use in such integrated flow cytometer applications, however, microfluidic footprints demonstrated so far preclude monolithic integration. Here, the scaling limits of throughput-per-footprint (TPFP) in using inertial focusing are explored by studying the interplay between theory, the effect of channel Reynolds numbers up to 1500 on focusing, the entry length for the laminar flow to develop, and pressure resistance of the microchannels. Inertial particle focusing is demonstrated with a TPFP up to 0.3 L/(min cm²) in high aspect-ratio rectangular microfluidic channels that are readily fabricated with a post-CMOS integratable process, suggesting at least a 100-fold improvement compared to previously demonstrated techniques. Not only can this be an enabling technology for realizing cost-effective monolithically integrated flow cytometry devices, but the methodology represented here can also open perspectives for miniaturization of many biomedical microfluidic applications requiring monolithic integration with microelectronics without compromising the throughput.

  1. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...

  2. [Focused musculoskeletal sonography].

    Science.gov (United States)

    Horn, Rudolf

    2015-09-16

    Even in emergent situations, focused musculoskeletal sonography must not be overlooked. It has a place in traumatology no less valuable than its place in internal medicine. It can be used to identify traumatic joint effusions, occult fractures and fissures, joint inflammation, muscle and tendon rupture; it can differentiate soft tissue swelling, locate a foreign body, or identify the location of fractures. Focused ultrasound should be performed by the attending physician directly at the patient’s bedside, in order to answer these specific questions.

  3. TRESK potassium channel in human T lymphoblasts

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez-Miguel, Dénison Selene, E-mail: amurusk@hotmail.com [Center for Biomedical Research, University of Colima, Av. 25 de Julio 965, Villa San Sebastian, C.P. 28045 Colima (Mexico); García-Dolores, Fernando, E-mail: garciaddf@yahoo.com [Department of Pathology, Institute of Forensic Sciences, Av. Niños Héroes 130, Col. Doctores, C.P. 06720 Mexico, DF (Mexico); Rosa Flores-Márquez, María, E-mail: mariafo31@yahoo.com.mx [National Medical Center of Occident (CMNO) IMSS, Belisario Dominguez 735, Col. Independencia Oriente, C.P. 44340 Guadalajara, Jalisco (Mexico); Delgado-Enciso, Iván [University of Colima, School of Medicine, Av. Universidad 333, Col. Las Viboras, C.P. 28040 Colima (Mexico); Pottosin, Igor, E-mail: pottosin@ucol.mx [Center for Biomedical Research, University of Colima, Av. 25 de Julio 965, Villa San Sebastian, C.P. 28045 Colima (Mexico); Dobrovinskaya, Oxana, E-mail: oxana@ucol.mx [Center for Biomedical Research, University of Colima, Av. 25 de Julio 965, Villa San Sebastian, C.P. 28045 Colima (Mexico)

    2013-05-03

    Highlights: • TRESK (KCNK18) mRNA is present in different T lymphoblastic cell lines. • KCNK18 mRNA was not found in resting peripheral blood lymphocytes. • Clinical samples of T lymphoblastic leukemias and lymphomas were positive for TRESK. • TRESK in T lymphoblasts has dual localization, in plasma membrane and intracellular. -- Abstract: TRESK (TWIK-related spinal cord K{sup +}) channel, encoded by KCNK18 gene, belongs to the double-pore domain K{sup +} channel family and in normal conditions is expressed predominantly in the central nervous system. In our previous patch-clamp study on Jurkat T lymphoblasts we have characterized highly selective K{sup +} channel with pharmacological profile identical to TRESK. In the present work, the presence of KCNK18 mRNA was confirmed in T lymphoblastic cell lines (Jurkat, JCaM, H9) but not in resting peripheral blood lymphocytes of healthy donors. Positive immunostaining for TRESK was demonstrated in lymphoblastic cell lines, in germinal centers of non-tumoral lymph nodes, and in clinical samples of T acute lymphoblastic leukemias/lymphomas. Besides detection in the plasma membrane, intracellular TRESK localization was also revealed. Possible involvement of TRESK channel in lymphocyte proliferation and tumorigenesis is discussed.

  4. Protocol channels as a new design alternative of covert channels

    CERN Document Server

    Wendzel, Steffen

    2008-01-01

    Covert channel techniques are used by attackers to transfer hidden data. There are two main categories of covert channels: timing channels and storage channels. This paper introduces a third category called protocol channels. A protocol channel switches one of at least two protocols to send a bit combination to a destination while sent packets include no hidden information themselves.

  5. Differential inertial focusing of particles in curved low-aspect-ratio microchannels

    Energy Technology Data Exchange (ETDEWEB)

    Russom, Aman; Gupta, Amit K; Nagrath, Sunitha; Di Carlo, Dino; Edd, Jon F; Toner, Mehmet [BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School, Boston, MA 02114 (United States)], E-mail: aman@kth.se

    2009-07-15

    Microfluidic-based manipulation of particles is of great interest due to the insight it provides into the physics of hydrodynamic forces. Here, we study a particle-size-dependent phenomenon based on differential inertial focusing that utilizes the flow characteristics of curved, low aspect ratio (channel width >> height), microfluidic channels. We report the emergence of two focusing points along the height of the channel (z-plane), where different sized particles are focused and ordered in evenly spaced trains at correspondingly different lateral positions within the channel cross-section. We applied the system for continuous ordering and separation of suspension particles.

  6. Surface vacancy channels through ion channeling

    Energy Technology Data Exchange (ETDEWEB)

    Redinger, Alex; Standop, Sebastian; Michely, Thomas [II. Physikalisches Institut, Universitaet Koeln, Zuelpicher Strasse 77, 50937 Koeln (Germany); Rosandi, Yudi; Urbassek, Herbert M. [Fachbereich Physik, Technische Universitaet Kaiserslautern, Erwin-Schroedinger-Strasse, D-67663 Kaiserslautern (Germany)

    2009-07-01

    Damage patterns of single ion impacts on Pt(111) have been studied by scanning tunneling microscopy (STM) and molecular dynamics simulations (MD). Low temperature experiments, where surface diffusion is absent, have been performed for argon and xenon ions with energies between 1 keV and 15 keV at an angle of incidence of 86 {sup circle} measured with respect to the surface normal. Ions hitting preexisting illuminated step edges penetrate into the crystal and are guided in open crystallographic directions, one or more layers underneath the surface (subsurface channeling). In the case of argon channeling the resulting surface damage consists of adatom and vacancy pairs aligned in ion beam direction. After xenon channeling thin surface vacancy trenches along the ion trajectories - surface vacancy channels - are observed. They result from very efficient sputtering and adatom production along the ion trajectory. This phenomena is well reproduced in molecular dynamics simulations of single ion impacts at 0 K. The damage patterns of Argon and Xenon impacts can be traced back to the different energy losses of the particles in the channel. Channeling distances exceeding 1000 A for 15 keV xenon impacts are observed.

  7. Spectral line polarimetry with a channeled polarimeter.

    Science.gov (United States)

    van Harten, Gerard; Snik, Frans; Rietjens, Jeroen H H; Martijn Smit, J; Keller, Christoph U

    2014-07-01

    Channeled spectropolarimetry or spectral polarization modulation is an accurate technique for measuring the continuum polarization in one shot with no moving parts. We show how a dual-beam implementation also enables spectral line polarimetry at the intrinsic resolution, as in a classic beam-splitting polarimeter. Recording redundant polarization information in the two spectrally modulated beams of a polarizing beam-splitter even provides the possibility to perform a postfacto differential transmission correction that improves the accuracy of the spectral line polarimetry. We perform an error analysis to compare the accuracy of spectral line polarimetry to continuum polarimetry, degraded by a residual dark signal and differential transmission, as well as to quantify the impact of the transmission correction. We demonstrate the new techniques with a blue sky polarization measurement around the oxygen A absorption band using the groundSPEX instrument, yielding a polarization in the deepest part of the band of 0.160±0.010, significantly different from the polarization in the continuum of 0.2284±0.0004. The presented methods are applicable to any dual-beam channeled polarimeter, including implementations for snapshot imaging polarimetry.

  8. SLSTR: a high accuracy dual scan temperature radiometer for sea and land surface monitoring from space

    Science.gov (United States)

    Coppo, P.; Ricciarelli, B.; Brandani, F.; Delderfield, J.; Ferlet, M.; Mutlow, C.; Munro, G.; Nightingale, T.; Smith, D.; Bianchi, S.; Nicol, P.; Kirschstein, S.; Hennig, T.; Engel, W.; Frerick, J.; Nieke, J.

    2010-10-01

    SLSTR is a high accuracy infrared radiometer which will be embarked in the Earth low-orbit Sentinel 3 operational GMES mission. SLSTR is an improved version of the previous AATSR and ATSR-1/2 instruments which have flown respectively on Envisat and ERS-1/2 ESA missions. SLSTR will provide data continuity with respect to these previous missions but with a substantial improvement due to its higher swaths (750 km in dual view and 1400 km in single view) which should permit global coverage of SST and LST measurements (at 1 km of spatial resolution in IR channels) with daily revisit time, useful for climatological and meteorological applications. Two more SWIR channels and a higher spatial resolution in the VIS/SWIR channels (0.5 km) are also implemented for a better clouds/aerosols screening. Two further additional channels for global scale fire monitoring are present at the same time as the other nominal channels.

  9. CNG and HCN channels: two peas, one pod.

    Science.gov (United States)

    Craven, Kimberley B; Zagotta, William N

    2006-01-01

    Cyclic nucleotide-activated ion channels play a fundamental role in a variety of physiological processes. By opening in response to intracellular cyclic nucleotides, they translate changes in concentrations of signaling molecules to changes in membrane potential. These channels belong to two families: the cyclic nucleotide-gated (CNG) channels and the hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels. The two families exhibit high sequence similarity and belong to the superfamily of voltage-gated potassium channels. Whereas HCN channels are activated by voltage and CNG channels are virtually voltage independent, both channels are activated by cyclic nucleotide binding. Furthermore, the channels are thought to have similar channel structures, leading to similar mechanisms of activation by cyclic nucleotides. However, although these channels are structurally and behaviorally similar, they have evolved to perform distinct physiological functions. This review describes the physiological roles and biophysical behavior of CNG and HCN channels. We focus on how similarities in structure and activation mechanisms result in common biophysical models, allowing CNG and HCN channels to be viewed as a single genre.

  10. A Dual Field-of-View Zoom Metalens

    CERN Document Server

    Zheng, Guoxing; Li, Zile; Zhang, Shuang; Mehmood, Muhammad Qasim; He, Pingan; Li, Song

    2016-01-01

    Conventional optical zoom system is bulky, expensive and complicated for real time adjustment. Recent progress in the metasurface research has provided a new solution to achieve innovative compact optical systems. In this paper, we propose a highly integrated zoom lens with dual field-of-view (FOV) based on double sided metasurfaces. With silicon nanobrick arrays of spatially varying orientations sitting on both side of a transparent substrate, this ultrathin zoom metalens can be designed to focus an incident circular polarized beam with spin-dependent FOVs without varying the focal plane, which is important for practical applications. The proposed dual FOV zoom metalens, with the advantages such as ultracompactness, flexibility and replicability, can find applications in fields which require ultracompact zoom imaging and beam focusing.

  11. Quantum channels and memory effects

    Science.gov (United States)

    Caruso, Filippo; Giovannetti, Vittorio; Lupo, Cosmo; Mancini, Stefano

    2014-10-01

    Any physical process can be represented as a quantum channel mapping an initial state to a final state. Hence it can be characterized from the point of view of communication theory, i.e., in terms of its ability to transfer information. Quantum information provides a theoretical framework and the proper mathematical tools to accomplish this. In this context the notion of codes and communication capacities have been introduced by generalizing them from the classical Shannon theory of information transmission and error correction. The underlying assumption of this approach is to consider the channel not as acting on a single system, but on sequences of systems, which, when properly initialized allow one to overcome the noisy effects induced by the physical process under consideration. While most of the work produced so far has been focused on the case in which a given channel transformation acts identically and independently on the various elements of the sequence (memoryless configuration in jargon), correlated error models appear to be a more realistic way to approach the problem. A slightly different, yet conceptually related, notion of correlated errors applies to a single quantum system which evolves continuously in time under the influence of an external disturbance which acts on it in a non-Markovian fashion. This leads to the study of memory effects in quantum channels: a fertile ground where interesting novel phenomena emerge at the intersection of quantum information theory and other branches of physics. A survey is taken of the field of quantum channels theory while also embracing these specific and complex settings.

  12. Pulse-width tunable multi-channel NRZ-to-RZ conversion with duplicate output

    Science.gov (United States)

    Yu, Yu; Zhang, Xinliang; Huang, Dexiu

    2012-01-01

    We demonstrate multi-channel non-return-to-zero (NRZ) to return-to-zero (RZ) conversions with tunable output pulse-width and single-to-dual function, using a phase modulator and an array waveguide grating (AWG), which acts both detuned multi-channel filter and demultiplexer. Four-channel NRZ signals after transmission can be converted to eight-channel RZ signals with timing jitter and extinction ratio improvement. Further transmission and bit error ratio (BER) measurements for the converted RZ signal show a good performance compared with conventional one.

  13. Higher order capacity statistics of multi-hop transmission systems over Rayleigh fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2012-03-01

    In this paper, we present an exact analytical expression to evaluate the higher order statistics of the channel capacity for amplify and forward (AF) multihop transmission systems operating over Rayleigh fading channels. Furthermore, we present simple and efficient closed-form expression to the higher order moments of the channel capacity of dual hop transmission system with Rayleigh fading channels. In order to analyze the behavior of the higher order capacity statistics and investigate the usefulness of the mathematical analysis, some selected numerical and simulation results are presented. Our results are found to be in perfect agreement. © 2012 IEEE.

  14. Youth Leadership. IDRA Focus.

    Science.gov (United States)

    IDRA Newsletter, 1995

    1995-01-01

    This theme issue focuses on motivating young people to learn by providing leadership opportunities in school. "Coca-Cola Valued Youth Program: Assessing Progress" (Josie Danini Supik) examines the program's success. This program, which trains high-risk middle and high school students as tutors of younger children, has dramatically…

  15. Neocortical focus: experimental view.

    Science.gov (United States)

    Timofeev, Igor; Chauvette, Sylvain; Soltani, Sara

    2014-01-01

    All brain normal or pathological activities occur in one of the states of vigilance: wake, slow-wave sleep, or REM sleep. Neocortical seizures preferentially occur during slow-wave sleep. We provide a description of neuronal behavior and mechanisms mediating such a behavior within neocortex taking place in natural states of vigilance as well as during seizures pointing to similarities and differences exhibited during sleep and seizures. A concept of epileptic focus is described using a model of cortical undercut, because in that model, the borders of the focus are well defined. In this model, as in other models of acquired epilepsy, the main factor altering excitability is deafferentation, which upregulates neuronal excitability that promotes generation of seizures. Periods of disfacilitation recorded during slow-wave sleep further upregulate neuronal excitability. It appears that the state of neurons and neuronal network in the epileptic focus produced by deafferentation are such that seizures cannot be generated there. Instead, seizures always start around the perimeter of the undercut cortex. Therefore, we define these areas as the seizure focus. In this zone, neuronal connectivity and excitability are moderately enhanced, lowering the threshold for seizure generation.

  16. A Material Focus

    DEFF Research Database (Denmark)

    Vallgårda, Anna K. A.; Sokoler, Tomas

    2009-01-01

    In this paper we build on the notion of computational composites, which hold a material perspective on computational technology. We argue that a focus on the material aspects of the technology could be a fruitful approach to achieve new expressions and to gain a new view on the technology's role...

  17. Adolescent Literacy. Focus On

    Science.gov (United States)

    Molineaux, Rebecca

    2009-01-01

    Evidence suggests that there is a crisis in adolescent literacy. Part of the problem is that students often receive little literacy instruction after elementary school. This "Focus On" examines the literacy instruction that adolescents need to be successful as they move on to more challenging texts in middle and high school. In addition, this…

  18. Curriculum Mapping. Focus On

    Science.gov (United States)

    Molineaux, Rebecca

    2008-01-01

    This "Focus On" discusses curriculum mapping, a process that allows educators to align the curriculum both within and across grades and to ensure that the curriculum is in line with school, local, and state standards. It outlines the steps of the curriculum mapping process from planning the mapping initiative to creating and editing curriculum…

  19. Thoracic applications of dual energy.

    Science.gov (United States)

    Remy-Jardin, Martine; Faivre, Jean-Baptiste; Pontana, Francois; Hachulla, Anne-Lise; Tacelli, Nunzia; Santangelo, Teresa; Remy, Jacques

    2010-01-01

    Recent technological advances in multidetector computed tomography (CT) have led to the introduction of dual-source CT, which allows acquisition of CT data at the same energy or at 2 distinct tube voltage settings during a single acquisition. The advantage of the former is improvement of temporal resolution, whereas the latter offers new options for CT imaging, allowing tissue characterization and functional analysis with morphologic evaluation. The most investigated application has been iodine mapping at pulmonary CT angiography. The material decomposition achievable opens up new options for recognizing substances poorly characterized by single-energy CT. Although it is too early to draw definitive conclusions on dual-energy CT applications, this article reviews the results already reported with the first generation of dual-source CT systems.

  20. Nonregenerative Dual-Hop Cooperative Links with Selection Diversity

    Directory of Open Access Journals (Sweden)

    Karagiannidis George K

    2006-01-01

    Full Text Available The end-to-end performance of dual-hop cooperative diversity systems equipped with nonregenerative relays and a selection combining receiver at the destination terminal over independent and nonidentical Nakagami- fading channels is studied. Closed-form expressions for the cumulative distribution function and the probability density function of the end-to-end signal-to-noise ratio ( are presented, while analytical formulae are derived for the moments and the moment generating function. Using these statistical results, closed-form expressions for the outage probability are presented for both channel state information and fixed gain relays. Furthermore, for the case of fixed gain relay, the average end-to-end , the amount of fading, and the average bit error rate can be numerically evaluated. The proposed mathematical analysis is complemented by numerical examples, including the effects on the overall performance of the s unbalancing as well as the fading severity.

  1. Dual-tip-enhanced ultrafast CARS nanoscopy

    CERN Document Server

    Ballmann, Charles W; Sinyukov, Alexander M; Sokolov, Alexei V; Voronine, Dmitri V

    2013-01-01

    Coherent anti-Stokes Raman scattering (CARS) and, in particular, femtosecond adaptive spectroscopic techniques (FAST CARS) have been successfully used for molecular spectroscopy and microscopic imaging. Recent progress in ultrafast nanooptics provides flexibility in generation and control of optical near fields, and holds promise to extend CARS techniques to the nanoscale. In this theoretical study, we demonstrate ultrafast subwavelentgh control of coherent Raman spectra of molecules in the vicinity of a plasmonic nanostructure excited by ultrashort laser pulses. The simulated nanostructure design provides localized excitation sources for CARS by focusing incident laser pulses into subwavelength hot spots via two self-similar nanolens antennas connected by a waveguide. Hot-spot-selective dual-tip-enhanced CARS (2TECARS) nanospectra of DNA nucleobases are obtained by simulating optimized pump, Stokes and probe near fields using tips, laser polarization- and pulse-shaping. This technique may be used to explore ...

  2. Bioaerosol detection and classification using dual excitation wavelength laser-induced fluorescence

    Science.gov (United States)

    Jonsson, Per; Wästerby, Pär.; Gradmark, Per-Åke; Hedborg, Julia; Larsson, Anders; Landström, Lars

    2015-05-01

    We present results obtained by a detection system designed to measure laser-induced fluorescence from individual aerosol particles using dual excitation wavelengths. The aerosol is sampled from ambient air and via a 1 mm diameter nozzle, surrounded by a sheath air flow, confined into a particle beam. A continuous wave blue laser at 404 nm is focused on the aerosol beam and two photomultiplier tubes monitor the presence of individual particles by simultaneous measuring the scattered light and any induced fluorescence. When a particle is present in the detection volume, a laser pulse is triggered from an ultraviolet laser at 263 nm and the corresponding fluorescence spectrum is acquired with a spectrometer based on a diffraction grating and a 32 channel photomultiplier tube array with single-photon sensitivity. The spectrometer measures the fluorescence spectra in the wavelength region from 250 to 800 nm. In the present report, data were measured on different monodisperse reference aerosols, simulants of biological warfare agents, and different interference aerosol particles, e.g. pollen. In the analysis of the experimental data, i.e., the time-resolved scattered and fluorescence signals from 404 nm c.w. light excitation and the fluorescence spectra obtained by a pulsed 263 nm laser source, we use multivariate data analysis methods to classify each individual aerosol particle.

  3. Moving Toward a Dual Income tax in Japan

    OpenAIRE

    Hiromtsu Ishi

    2006-01-01

    The aim of this paper is to explore the recent move toward a system of dual income tax (DIT) in Japan, tracing back to the development of the individual income tax in the postwar period. Focus is upon very pragmatic considerations institutionally, rather than abstract theoretical arguments. In what follows, main issues are divided into four parts. First, as an introductory part, the basic features of Nordic DIT are summarized briefly. Second, the shift from a comprehensive income tax (CIT) an...

  4. DUAL BAND MONOPOLE ANTENNA DESIGN

    Directory of Open Access Journals (Sweden)

    P. Jithu

    2013-06-01

    Full Text Available The WLAN and Bluetooth applications become popular in mobile devices, integrating GSM and ISM bands operation in one compact antenna, can reduce the size of mobile devices. Recently, lot many investigations are carried out in designing a dual band antennas with operating frequencies in GSM band and in ISM band for mobile devices. Printed monopoles are under this investigation. In this paper, dual-band printed monopoles are presented to operate at GSM band i.e. 900 MHz and ISM band i.e. 2.4 GHz. We intend to observe the antenna characteristics on the network analyzer and verify the theoretical results with the practical ones.

  5. Towards a big crunch dual

    Energy Technology Data Exchange (ETDEWEB)

    Hertog, Thomas E-mail: hertog@vulcan2.physics.ucsb.edu; Horowitz, Gary T

    2004-07-01

    We show there exist smooth asymptotically anti-de Sitter initial data which evolve to a big crunch singularity in a low energy supergravity limit of string theory. This opens up the possibility of using the dual conformal field theory to obtain a fully quantum description of the cosmological singularity. A preliminary study of this dual theory suggests that the big crunch is an endpoint of evolution even in the full string theory. We also show that any theory with scalar solitons must have negative energy solutions. The results presented here clarify our earlier work on cosmic censorship violation in N=8 supergravity. (author)

  6. DESIGN OF A DUAL KEYBOARD

    Directory of Open Access Journals (Sweden)

    V. Ragavi

    2013-01-01

    Full Text Available The design of a computer keyboard with dual function is proposed. This computer keyboard called Dual Keyboard can function both as a normal keyboard and as a pressure sensitive keyboard. The proposed device has a switch that decides the function. The keyboard makes use of sensors placed beneath the keys to measure the pressure applied on the key by the user. This device has many applications. In this study, it is applied to mitigate Denial of Service (DoS attack.

  7. Nuclearity for Dual Operator Spaces

    Indian Academy of Sciences (India)

    Zhe Dong; Jicheng Tao

    2010-02-01

    In this short paper, we study the nuclearity for the dual operator space $V^∗$ of an operator space . We show that $V^∗$ is nuclear if and only if $V^{∗∗∗}$ is injective, where $V^{∗∗∗}$ is the third dual of . This is in striking contrast to the situation for general operator spaces. This result is used to prove that $V^{∗∗}$ is nuclear if and only if is nuclear and $V^{∗∗}$ is exact.

  8. Charged and Neutral Particles Channeling Phenomena Channeling 2008

    Science.gov (United States)

    Dabagov, Sultan B.; Palumbo, Luigi

    2010-04-01

    On the discovery of coherent Bremsstrahlung in a single crystal at the Frascati National Laboratories / C. Barbiellini, G. P. Murtas and S. B. Dabagov -- Advances in coherent Bremsstrahlung and LPM-effect studies (to the lOOth anniversary from the birth of L. D. Landau) / N. F. Shul'ga -- Spectra of radiation and created particles at intermediate energy in oriented crystal taking into account energy loss / V. N. Baier and V. M. Katkov -- The coherent Bremsstrahlung beam at MAX-lab facility / K. Fissum ... [et al.] -- Radiation from thin, structured targets (CERN NA63) / A. Dizdar -- Hard incoherent radiation in thick crystals / N. F. Shul'ga, V. V. Syshchenko and A. I. Tarnovsky -- Coherent Bremsstrahlung in periodically deformed crystals with a complex base / A. R. Mkrtchyan, A. A. Saharian and V. V. Parazian -- Induction of coherent x-ray Bremsstrahlung in crystals under the influence of acoustic waves / A. R. Mkrtchyan and V. V. Parazian -- Coherent processes in bent single crystals / V. A. Maisheev -- Experimental and theoretical investigation of complete transfer phenomenon for media with various heat exchange coefficients / A. R. Mkrtchyan, A. E. Movsisyan and V. R. Kocharyan -- Coherent pair production in crystals / A. R. Mkrtchyan, A. A. Saharian and V. V. Parazian -- Negative particle planar and axial channeling and channeling collimation / R. A. Carrigan, Jr. -- CERN crystal-based collimation in modern hadron colliders / W. Scandale -- Studies and application of bent crystals for beam steering at 70 GeV IHEP accelerator / A. G. Afonin ... [et al.] -- Crystal collimation studies at the Tevatron (T-980) / N. V. Mokhov ... [et al.] -- Fabrication of crystals for channeling of particles in accellerators / A. Mazzolari ... [et al.] -- New possibilities to facilitate collimation of both positively and negatively charged particle beams by crystals / V. Guidi, A. Mazzolari and V. V. Tikhomirov -- Increase of probability of particle capture into the channeling

  9. Sparsity and spectral properties of dual frames

    CERN Document Server

    Krahmer, Felix; Lemvig, Jakob

    2012-01-01

    We study sparsity and spectral properties of dual frames of a given finite frame. We show that any finite frame has a dual with no more than $n^2$ non-vanishing entries, where $n$ denotes the ambient dimension, and that for most frames no sparser dual is possible. Moreover, we derive an expression for the exact sparsity level of the sparsest dual for any given finite frame using a generalized notion of spark. We then study the spectral properties of dual frames in terms of singular values of the synthesis operator. We provide a complete characterization for which spectral patterns of dual frames are possible for a fixed frame. For many cases, we provide simple explicit constructions for dual frames with a given spectrum, in particular, if the constraint on the dual is that it be tight.

  10. A dual method for maximum entropy restoration

    Science.gov (United States)

    Smith, C. B.

    1979-01-01

    A simple iterative dual algorithm for maximum entropy image restoration is presented. The dual algorithm involves fewer parameters than conventional minimization in the image space. Minicomputer test results for Fourier synthesis with inadequate phantom data are given.

  11. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    is demonstrated on a selection of general science journals and on a selection of medical journals. The reference lists of each journal are compared year by year, and the percentage of re-citations is calculated by dividing the number of re-citations with the total number of citations each year. Analysis......Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...

  12. Focusing of electromagnetic waves

    Energy Technology Data Exchange (ETDEWEB)

    Dhayalan, V.

    1996-12-31

    The focusing of electromagnetic waves inside a slab has been examined together with two special cases in which the slab is reduced to a single interface or a single medium. To that end the exact solutions for the fields inside a layered medium have been used, given in terms of the outside current source in order to obtain the solutions for the focused electric field inside a slab. Both exact and asymptotic solutions of the problem have been considered, and the validity of the latter has been discussed. The author has developed a numerical algorithm for evaluation of the diffraction integral with special emphasis on reducing the computing time. The numerical techniques in the paper can be readily applied to evaluate similar diffraction integrals occurring e.g. in microstrip antennas. 46 refs.

  13. Focus on Succes

    OpenAIRE

    Ivan Slimák; Kristina Zgodavova

    2011-01-01

    The Editor wishes to present the need and form of turning the focus of individuals and organisations to success, based on evaluating understanding of the situation, on complex improving the quality of work, production and life, and on awareness of accountability for consequences of one’s actions in the given environment and time. Understood by success is sustained financial and non-financial prosperity, whilst decisive is the evaluating process, the key element is loyalty of natural and physi...

  14. Dense Plasma Focus Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hui [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Li, Shengtai [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jungman, Gerard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes-Sterbenz, Anna Catherine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-31

    The mechanisms for pinch formation in Dense Plasma Focus (DPF) devices, with the generation of high-energy ions beams and subsequent neutron production over a relatively short distance, are not fully understood. Here we report on high-fidelity 2D and 3D numerical magnetohydrodynamic (MHD) simulations using the LA-COMPASS code to study the pinch formation dynamics and its associated instabilities and neutron production.

  15. Subsurface contaminants focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites.

  16. [Comparative pharmacophore analysis of dual dopamine D2/5-HT(2A) receptor antagonists].

    Science.gov (United States)

    Guo, Yan-shen; Guo, Zong-ru

    2009-03-01

    Dual dopamine D2/5-HT2A receptor antagonists have potent activity and are referred to atypical antipsychotics due to their lower propensity to elicit EPS and their moderate efficacy toward negative symptoms. However, an on-going challenge in developing atypical antipsychotics drugs is to maintain the favorable profiles and avoid of cardiovascular risk. In this paper, comparative pharmacophore analysis of dual dopamine D2/5-HT2A receptor antagonists, hERG K+ channel blockers, and alA adrenoceptor antagonists is carried out, and the results could give some insight into multi-target drug design.

  17. No-ghost theorem for the Pomeron sector of the dual model

    CERN Document Server

    Olive, D

    1973-01-01

    The Pomeron sector of the dual model comprises a spectrum of states obtained by factorizing the residues of poles occurring in a certain channel (with vacuum quantum numbers) of the orientable non-planar single loop graphs of the conventional dual model considered in 26 space-time dimensions. The authors show that the spectrum of Pomeron states which couple between external physical particle states are transverse and hence positive definite and thus ghost-free. The same states also factorize the Virasoro-Shapiro model which now appears very likely to be the scattering theory of Pomeron ground states. (17 refs).

  18. Two-way quantum communication channels

    CERN Document Server

    Childs, A M; Lo, H K; Childs, Andrew M.; Leung, Debbie W.; Lo, Hoi-Kwong

    2005-01-01

    We consider communication between two parties using a bipartite quantum operation, which constitutes the most general quantum mechanical model of two-party communication. We primarily focus on the simultaneous forward and backward communication of classical messages. For the case in which the two parties share unlimited prior entanglement, we give inner and outer bounds on the achievable rate region that generalize classical results due to Shannon. In particular, using a protocol of Bennett, Harrow, Leung, and Smolin, we give a one-shot expression in terms of the Holevo information for the entanglement-assisted one-way capacity of a two-way quantum channel. As applications, we rederive two known additivity results for one-way channel capacities: the entanglement-assisted capacity of a general one-way channel, and the unassisted capacity of an entanglement-breaking one-way channel.

  19. Dual of QCD with One Adjoint Fermion

    CERN Document Server

    Mojaza, Matin; Pica, Claudio; Sannino, Francesco

    2011-01-01

    We construct the magnetic dual of QCD with one adjoint Weyl fermion. The dual is a consistent solution of the 't Hooft anomaly matching conditions, allows for flavor decoupling and remarkably constitutes the first nonsupersymmetric dual valid for any number of colors. The dual allows to bound the anomalous dimension of the Dirac fermion mass operator to be less than one in the conformal window.

  20. Dual symmetry in a generalized Maxwell theory

    CERN Document Server

    Brandt, F T; McKeon, D G C

    2016-01-01

    We examine Podolsky's electrodynamics, which is noninvariant under the usual duality transformation. We deduce a generalization of Hodge's star duality, which leads to a dual gauge field and restores to a certain extent the dual symmetry. The model becomes fully dual symmetric asymptotically when it reduces to the Maxwell theory. We argue that this strict dual symmetry directly implies the existence of the basic invariants of the electromagnetic fields.

  1. Voltage-Gated Calcium Channels in Nociception

    Science.gov (United States)

    Yasuda, Takahiro; Adams, David J.

    Voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of membrane ion channels ubiquitously expressed throughout the central and peripheral nervous systems. VGCCs contribute to various physiological processes and transduce electrical activity into other cellular functions. This chapter provides an overview of biophysical properties of VGCCs, including regulation by auxiliary subunits, and their physiological role in neuronal functions. Subsequently, then we focus on N-type calcium (Cav2.2) channels, in particular their diversity and specific antagonists. We also discuss the role of N-type calcium channels in nociception and pain transmission through primary sensory dorsal root ganglion neurons (nociceptors). It has been shown that these channels are expressed predominantly in nerve terminals of the nociceptors and that they control neurotransmitter release. To date, important roles of N-type calcium channels in pain sensation have been elucidated genetically and pharmacologically, indicating that specific N-type calcium channel antagonists or modulators are particularly useful as therapeutic drugs targeting chronic and neuropathic pain.

  2. Microflow Cytometers with Integrated Hydrodynamic Focusing

    Directory of Open Access Journals (Sweden)

    Martin Schmidt

    2013-04-01

    Full Text Available This study demonstrates the suitability of microfluidic structures for high throughput blood cell analysis. The microfluidic chips exploit fully integrated hydrodynamic focusing based on two different concepts: Two-stage cascade focusing and spin focusing (vortex principle. The sample—A suspension of micro particles or blood cells—is injected into a sheath fluid streaming at a substantially higher flow rate, which assures positioning of the particles in the center of the flow channel. Particle velocities of a few m/s are achieved as required for high throughput blood cell analysis. The stability of hydrodynamic particle positioning was evaluated by measuring the pulse heights distributions of fluorescence signals from calibration beads. Quantitative assessment based on coefficient of variation for the fluorescence intensity distributions resulted in a value of about 3% determined for the micro-device exploiting cascade hydrodynamic focusing. For the spin focusing approach similar values were achieved for sample flow rates being 1.5 times lower. Our results indicate that the performances of both variants of hydrodynamic focusing suit for blood cell differentiation and counting. The potential of the micro flow cytometer is demonstrated by detecting immunologically labeled CD3 positive and CD4 positive T-lymphocytes in blood.

  3. Broadening the focus of evaluation: An experiment

    Directory of Open Access Journals (Sweden)

    Chakraborty, S.

    2010-01-01

    Full Text Available Evaluation of student performance in any course, especially those delivered in a management programme, poses a serious challenge; more so, in a course like ‘Business Communication’, where oral communication ought to form an integral part of evaluation. This paper presents various details of an experiment, conducted with a view to introduce this much needed component in the evaluation process. Essential purpose of the exercise was to try and broaden the focus of evaluation, simultaneously enlarging its scope. The need to maintain certain amount of objectivity and transparency was taken as critical. Group Discussion was used as a tool. A process was developed with the objective of getting every student evaluated on both written as well as non-written skills. A two-sided evaluation mechanism was put in place to achieve the dual purpose of leaning and evaluation. Statistical analysis of the results suggests that the experiment was a useful one. The student feedback, too, was favourable.

  4. Physical-Layer Security over Correlated Erasure Channels

    OpenAIRE

    Harrison, W. K.; Almeida, J; McLaughlin, S. W.; Barros, J.

    2011-01-01

    We explore the additional security obtained by noise at the physical layer in a wiretap channel model setting. Security enhancements at the physical layer have been proposed recently using a secrecy metric based on the degrees of freedom that an attacker has with respect to the sent ciphertext. Prior work focused on cases in which the wiretap channel could be modeled as statistically independent packet erasure channels for the legitimate receiver and an eavesdropper. In this paper, we go beyo...

  5. Dual Enrollment in Spanish: One Working Model

    Science.gov (United States)

    Bloom, Melanie; Chambers, Laura

    2009-01-01

    Dual enrollment is now a nation-wide phenomenon as all 50 states currently offer some form of dual-enrollment program to secondary-school students (Karp, Bailey, Hughes, and Fermin 2005). However, dual enrollment itself is often difficult to define as programs vary from school to school (Jordan, Cavalluzzo, and Corallo 2006). Therefore, language…

  6. Sparsity and spectral properties of dual frames

    DEFF Research Database (Denmark)

    Krahmer, Felix; Kutyniok, Gitta; Lemvig, Jakob

    2013-01-01

    We study sparsity and spectral properties of dual frames of a given finite frame. We show that any finite frame has a dual with no more than $n^2$ non-vanishing entries, where $n$ denotes the ambient dimension, and that for most frames no sparser dual is possible. Moreover, we derive an expressio...

  7. Dual Enrollment for High School Students

    Science.gov (United States)

    Edwards, Linsey; Hughes, Katherine

    2011-01-01

    Dual enrollment programs allow high school students to enroll in college courses and potentially earn college credit. The term concurrent enrollment is sometimes used interchangeably with dual enrollment, and sometimes to refer to a particular model of dual enrollment. In some programs, students earn high school and college credit simultaneously;…

  8. Inertial Focusing of Microparticles in Curvilinear Microchannels

    Science.gov (United States)

    Özbey, Arzu; Karimzadehkhouei, Mehrdad; Akgönül, Sarp; Gozuacik, Devrim; Koşar, Ali

    2016-12-01

    A passive, continuous and size-dependent focusing technique enabled by “inertial microfluidics”, which takes advantage of hydrodynamic forces, is implemented in this study to focus microparticles. The objective is to analyse the decoupling effects of inertial forces and Dean drag forces on microparticles of different sizes in curvilinear microchannels with inner radius of 800 μm and curvature angle of 280°, which have not been considered in the literature related to inertial microfluidics. This fundamental approach gives insight into the underlying physics of particle dynamics and offers continuous, high-throughput, label-free and parallelizable size-based particle separation. Our design allows the same footprint to be occupied as straight channels, which makes parallelization possible with optical detection integration. This feature is also useful for ultrahigh-throughput applications such as flow cytometers with the advantages of reduced cost and size. The focusing behaviour of 20, 15 and 10 μm fluorescent polystyrene microparticles was examined for different channel Reynolds numbers. Lateral and vertical particle migrations and the equilibrium positions of these particles were investigated in detail, which may lead to the design of novel microfluidic devices with high efficiency and high throughput for particle separation, rapid detection and diagnosis of circulating tumour cells with reduced cost.

  9. CE dual-homing protection in layer 1 VPN

    Science.gov (United States)

    Du, Shu; Peng, Yunfeng; Long, Keping

    2008-11-01

    Layer 1 VPN (L1VPN) extends the notion of VPN to the optical domain to provide virtually dedicated circuit like leased lines, so that the security is more enhanced. Despite their secure gains from channel isolation, VPNs still suffer fragilities resulting from link-failures or node-failures. Extensive activities on survivability designs for wavelength-routed optical networks are proposed, including various protection and restoration schemes, but concerns on network edge are rare. Dual-homing is an effective skill to achieve survivability gains for L1VPNs. There are two dual-homing mode: Active/Standby mode and Load-Sharing mode In this paper, we investigate the problem of PE assignment, which is the key of dual-homing design and is NP-hard. We formulate it as an integer programming problem, and propose heuristic solutions. Simulation results show that the proposed solutions work in a correct and effective way and the Load-Sharing mode has higher bandwidth efficiency than Active/Standby mode.

  10. Quantum feedback channels

    CERN Document Server

    Bowen, G

    2002-01-01

    In classical information theory the capacity of a noisy communication channel cannot be increased by the use of feedback. In quantum information theory the no-cloning theorem means that noiseless copying and feedback of quantum information cannot be achieved. In this paper, quantum feedback is defined as the unlimited use of a noiseless quantum channel from receiver to sender. Given such quantum feedback, it is shown to provide no increase in the entanglement-assisted capacities of a noisy quantum channel, in direct analogy to the classical case. It is also shown that in various cases of non-assisted capacities, feedback can increase the capacity of many quantum channels.

  11. Dual Processing and Diagnostic Errors

    Science.gov (United States)

    Norman, Geoff

    2009-01-01

    In this paper, I review evidence from two theories in psychology relevant to diagnosis and diagnostic errors. "Dual Process" theories of thinking, frequently mentioned with respect to diagnostic error, propose that categorization decisions can be made with either a fast, unconscious, contextual process called System 1 or a slow, analytical,…

  12. Pairs of dual periodic frames

    DEFF Research Database (Denmark)

    Christensen, Ole; Goh, Say Song

    2012-01-01

    is needed. The purpose of the present paper is to provide constructions of dual pairs of frames in the setting of the Hilbert space of periodic functions L2(0,2π). The frames constructed are given explicitly as trigonometric polynomials, which allows for an efficient calculation of the coefficients...

  13. Physical Health and Dual Diagnosis

    OpenAIRE

    Robson, Debbie; Keen, Sarah; Mauro, Pia

    2008-01-01

    The physical health of people with mental illness may be neglected for a variety of reasons. This paper looks at the common physical health problems experienced by people with a dual diagnosis of substance misuse and serious mental illness, and suggests ways of assessing and managing them.

  14. Distributive Network Utility Maximization (NUM) over Time-Varying Fading Channels

    CERN Document Server

    Chen, Junting; Lau, Vincent K N

    2011-01-01

    Distributed network utility maximization (NUM) has received an increasing intensity of interest over the past few years. Distributed solutions (e.g., the primal-dual gradient method) have been intensively investigated under fading channels. As such distributed solutions involve iterative updating and explicit message passing, it is unrealistic to assume that the wireless channel remains unchanged during the iterations. Unfortunately, the behavior of those distributed solutions under time-varying channels is in general unknown. In this paper, we shall investigate the convergence behavior and tracking errors of the iterative primal-dual scaled gradient algorithm (PDSGA) with dynamic scaling matrices (DSC) for solving distributive NUM problems under time-varying fading channels. We shall also study a specific application example, namely the multi-commodity flow control and multi-carrier power allocation problem in multi-hop ad hoc networks. Our analysis shows that the PDSGA converges to a limit region rather tha...

  15. Intra-membrane molecular interactions of K+ channel proteins :

    Energy Technology Data Exchange (ETDEWEB)

    Moczydlowski, Edward G.

    2013-07-01

    Ion channel proteins regulate complex patterns of cellular electrical activity and ionic signaling. Certain K+ channels play an important role in immunological biodefense mechanisms of adaptive and innate immunity. Most ion channel proteins are oligomeric complexes with the conductive pore located at the central subunit interface. The long-term activity of many K+ channel proteins is dependent on the concentration of extracellular K+; however, the mechanism is unclear. Thus, this project focused on mechanisms underlying structural stability of tetrameric K+ channels. Using KcsA of Streptomyces lividans as a model K+ channel of known structure, the molecular basis of tetramer stability was investigated by: 1. Bioinformatic analysis of the tetramer interface. 2. Effect of two local anesthetics (lidocaine, tetracaine) on tetramer stability. 3. Molecular simulation of drug docking to the ion conduction pore. The results provide new insights regarding the structural stability of K+ channels and its possible role in cell physiology.

  16. Plasma Channel Diagnostic Based on Laser Centroid Oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Gonsalves, Anthony; Nakamura, Kei; Lin, Chen; Osterhoff, Jens; Shiraishi, Satomi; Schroeder, Carl; Geddes, Cameron; Toth, Csaba; Esarey, Eric; Leemans, Wim

    2010-09-09

    A technique has been developed for measuring the properties of discharge-based plasma channels by monitoring the centroid location of a laser beam exiting the channel as a function of input alignment offset between the laser and the channel. The centroid position of low-intensity (<10{sup 14}Wcm{sup -2}) laser pulses focused at the input of a hydrogen-filled capillary discharge waveguide was scanned and the exit positions recorded to determine the channel shape and depth with an accuracy of a few %. In addition, accurate alignment of the laser beam through the plasma channel can be provided by minimizing laser centroid motion at the channel exit as the channel depth is scanned either by scanning the plasma density or the discharge timing. The improvement in alignment accuracy provided by this technique will be crucial for minimizing electron beam pointing errors in laser plasma accelerators.

  17. Simulation of springback and microstructural analysis of dual phase steels

    Science.gov (United States)

    Kalyan, T. Sri.; Wei, Xing; Mendiguren, Joseba; Rolfe, Bernard

    2013-12-01

    With increasing demand for weight reduction and better crashworthiness abilities in car development, advanced high strength Dual Phase (DP) steels have been progressively used when making automotive parts. The higher strength steels exhibit higher springback and lower dimensional accuracy after stamping. This has necessitated the use of simulation of each stamped component prior to production to estimate the part's dimensional accuracy. Understanding the micro-mechanical behaviour of AHSS sheet may provide more accuracy to stamping simulations. This work can be divided basically into two parts: first modelling a standard channel forming process; second modelling the micro-structure of the process. The standard top hat channel forming process, benchmark NUMISHEET'93, is used for investigating springback effect of WISCO Dual Phase steels. The second part of this work includes the finite element analysis of microstructures to understand the behaviour of the multi-phase steel at a more fundamental level. The outcomes of this work will help in the dimensional control of steels during manufacturing stage based on the material's microstructure.

  18. Direct social perception and dual process theories of mindreading.

    Science.gov (United States)

    Herschbach, Mitchell

    2015-11-01

    The direct social perception (DSP) thesis claims that we can directly perceive some mental states of other people. The direct perception of mental states has been formulated phenomenologically and psychologically, and typically restricted to the mental state types of intentions and emotions. I will compare DSP to another account of mindreading: dual process accounts that posit a fast, automatic "Type 1" form of mindreading and a slow, effortful "Type 2" form. I will here analyze whether dual process accounts' Type 1 mindreading serves as a rival to DSP or whether some Type 1 mindreading can be perceptual. I will focus on Apperly and Butterfill's dual process account of mindreading epistemic states such as perception, knowledge, and belief. This account posits a minimal form of Type 1 mindreading of belief-like states called registrations. I will argue that general dual process theories fit well with a modular view of perception that is considered a kind of Type 1 process. I will show that this modular view of perception challenges and has significant advantages over DSP's phenomenological and psychological theses. Finally, I will argue that if such a modular view of perception is accepted, there is significant reason for thinking Type 1 mindreading of belief-like states is perceptual in nature. This would mean extending the scope of DSP to at least one type of epistemic state.

  19. Spectral domain optical coherence tomography with dual-balanced detection

    Science.gov (United States)

    Bo, En; Liu, Xinyu; Chen, Si; Luo, Yuemei; Wang, Nanshuo; Wang, Xianghong; Liu, Linbo

    2016-03-01

    We developed a spectral domain optical coherence tomography (SD-OCT) system employing dual-balanced detection (DBD) for direct current term suppression and SNR enhancement, especially for auto-autocorrelation artifacts reduction. The DBD was achieved by using a beam splitter to building a free-space Michelson interferometer, which generated two interferometric spectra with a phase difference of π. These two phase-opposed spectra were guided to the spectrometer through two single mode fibers of the 8 fiber v-groove array and acquired by ultizing the upper two lines of a three-line CCD camera. We rotated this fiber v-groove array by 1.35 degrees to focus two spectra onto the first and second line of the CCD camera. Two spectra were aligned by optimum spectrum matching algorithm. By subtracting one spectrum from the other, this dual-balanced detection system achieved a direct current term suppression of ~30 dB, SNR enhancement of ~3 dB, and auto-autocorrelation artifacts reduction of ~10 dB experimentally. Finally we respectively validated the feasibility and performance of dual-balanced detection by imaging a glass plate and swine corneal tissue ex vivo. The quality of images obtained using dual-balanced detection was significantly improved with regard to the conventional single-detection (SD) images.

  20. The Individually Focused Interview

    DEFF Research Database (Denmark)

    Clausen, Aksel Skovgaard

    2012-01-01

    In this paper, I argue—with an example—that under certain conditions replacement of audio transcriptions with a combination of simultaneously taken and jointly produced notes can be done without affecting reliability, validity, and transparency. These conditions are: (1) professional or otherwise...... relatively “strong” interviewees (interview persons: IPs) with diverse backgrounds; (2) thorough planning of the interview with well-focused themes; and (3) a thorough and repeated introduction to the interview. The omission of audio transcriptions is an obvious solution to the researcher who wants a breadth...