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Sample records for channel closure ameliorates

  1. Climate Change and Closure of Thyborøn Channel

    DEFF Research Database (Denmark)

    Larsen, Torben

    of the channel. The coasts in the Limfjord are most sensitive to flooding and the climate changes will call for many types of precautions for the rising sea level. The closure of Thyborøn Channel should be understood as an alternative to many local solutions especially in the western part of the......The matter of Thyborøn Channel is the culmination of the coastal engineering in Denmark. Many hundreds of man-years have been spent by engineers and scientists on the planning and evaluation of the complex of problems briefly outlined in the following. After having been separated for more than 700...... years the connection between the North Sea and the Limfjord was established by a storm surge in 1825. The opening drastically changed the salinity and ecology in the fjord. In the first part of the 20th century a fear of flooding of the city of Thyborøn became greater. In 1946 the Danish Parliament...

  2. MODELING OF THE DIVERSION CHANNEL CLOSURE FOR THE THIRD STAGE OF THE THREE GORGES PROJECT

    Institute of Scientific and Technical Information of China (English)

    Guangqian WANG; Baosheng WU; Junqiang XIA

    2004-01-01

    The closure of third stage diversion channel for the Three Gorges Dam is characterized by large closure discharge, large drop in water surface, and high gap velocity. 1D and 2D flow mathematical models were used in this paper to simulate the hydraulic conditions during the closure. The variation of discharge in the diversion channel and the drops in water surface shared by the upstream and downstream cofferdams were computed using the 1D model, and the detailed hydraulic patterns in the diversion channel were simulated using the 2D model. The computed results indicate that the designed closure scheme for discharge of 9,010 m3/s was feasible for construction, while the designed closure scheme for discharge of 12,200 m3/s was inapplicable.

  3. Guard cell SLAC1-type anion channels mediate flagellin-induced stomatal closure.

    Science.gov (United States)

    Guzel Deger, Aysin; Scherzer, Sönke; Nuhkat, Maris; Kedzierska, Justyna; Kollist, Hannes; Brosché, Mikael; Unyayar, Serpil; Boudsocq, Marie; Hedrich, Rainer; Roelfsema, M Rob G

    2015-10-01

    During infection plants recognize microbe-associated molecular patterns (MAMPs), and this leads to stomatal closure. This study analyzes the molecular mechanisms underlying this MAMP response and its interrelation with ABA signaling. Stomata in intact Arabidopsis thaliana plants were stimulated with the bacterial MAMP flg22, or the stress hormone ABA, by using the noninvasive nanoinfusion technique. Intracellular double-barreled microelectrodes were applied to measure the activity of plasma membrane ion channels. Flg22 induced rapid stomatal closure and stimulated the SLAC1 and SLAH3 anion channels in guard cells. Loss of both channels resulted in cells that lacked flg22-induced anion channel activity and stomata that did not close in response to flg22 or ABA. Rapid flg22-dependent stomatal closure was impaired in plants that were flagellin receptor (FLS2)-deficient, as well as in the ost1-2 (Open Stomata 1) mutant, which lacks a key ABA-signaling protein kinase. By contrast, stomata of the ABA protein phosphatase mutant abi1-1 (ABscisic acid Insensitive 1) remained flg22-responsive. These data suggest that the initial steps in flg22 and ABA signaling are different, but that the pathways merge at the level of OST1 and lead to activation of SLAC1 and SLAH3 anion channels. PMID:25932909

  4. Glucose- and mannose-induced stomatal closure is mediated by ROS production, Ca(2+) and water channel in Vicia faba.

    Science.gov (United States)

    Li, Yan; Xu, ShanShan; Gao, Jing; Pan, Sha; Wang, GenXuan

    2016-03-01

    Sugars act as vital signaling molecules that regulate plant growth, development and stress responses. However, the effects of sugars on stomatal movement have been unclear. In our study, we explored the effects of monosaccharides such as glucose and mannose on stomatal aperture. Here, we demonstrate that glucose and mannose trigger stomatal closure in a dose- and time-dependent manner in epidermal peels of broad bean (Vicia faba). Pharmacological studies revealed that glucose- and mannose-induced stomatal closure was almost completely inhibited by two reactive oxygen species (ROS) scavengers, catalase (CAT) and reduced glutathione (GSH), was significantly abolished by an NADPH oxidase inhibitor, diphenylene iodonium chloride (DPI), whereas they were hardly affected by a peroxidase inhibitor, salicylhydroxamic acid (SHAM). Furthermore, glucose- and mannose-induced stomatal closure was strongly inhibited by a Ca(2+) channel blocker, LaCl3 , a Ca(2+) chelator, ethyleneglycol-bis(beta-aminoethylether)-N,N'-tetraacetic acid (EGTA) and two water channel blockers, HgCl2 and dimethyl sulfoxide (DMSO); whereas the inhibitory effects of the water channel blockers were essentially abolished by the reversing agent β-mercaptoethanol (β-ME). These results suggest that ROS production mainly via NADPH oxidases, Ca(2+) and water channels are involved in glucose- and mannose-induced stomatal closure. PMID:26046775

  5. T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression

    Directory of Open Access Journals (Sweden)

    Sarah Abdul-Wajid

    2015-10-01

    Full Text Available A major class of human birth defects arise from aberrations during neural tube closure (NTC. We report on a NTC signaling pathway requiring T-type calcium channels (TTCCs that is conserved between primitive chordates (Ciona and Xenopus. With loss of TTCCs, there is a failure to seal the anterior neural folds. Accompanying loss of TTCCs is an upregulation of EphrinA effectors. Ephrin signaling is known to be important in NTC, and ephrins can affect both cell adhesion and repulsion. In Ciona, ephrinA-d expression is downregulated at the end of neurulation, whereas, with loss of TTCC, ephrinA-d remains elevated. Accordingly, overexpression of ephrinA-d phenocopied TTCC loss of function, while overexpression of a dominant-negative Ephrin receptor was able to rescue NTC in a Ciona TTCC mutant. We hypothesize that signaling through TTCCs is necessary for proper anterior NTC through downregulation of ephrins, and possibly elimination of a repulsive signal.

  6. Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Mahy Nicole

    2011-11-01

    Full Text Available Abstract Background Multiple Sclerosis (MS is an acquired inflammatory demyelinating disorder of the central nervous system (CNS and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others neurotoxic agents. Previous studies have demonstrated that microglia expresses ATP-sensitive potassium (KATP channels and its pharmacological activation can provide neuroprotective and anti-inflammatory effects. In this study, we have examined the effect of oral administration of KATP channel opener diazoxide on induced experimental autoimmune encephalomyelitis (EAE, a mouse model of MS. Methods Anti-inflammatory effects of diazoxide were studied on lipopolysaccharide (LPS and interferon gamma (IFNγ-activated microglial cells. EAE was induced in C57BL/6J mice by immunization with myelin oligodendrocyte glycoprotein peptide (MOG35-55. Mice were orally treated daily with diazoxide or vehicle for 15 days from the day of EAE symptom onset. Treatment starting at the same time as immunization was also assayed. Clinical signs of EAE were monitored and histological studies were performed to analyze tissue damage, demyelination, glial reactivity, axonal loss, neuronal preservation and lymphocyte infiltration. Results Diazoxide inhibited in vitro nitric oxide (NO, tumor necrosis factor alpha (TNF-α and interleukin-6 (IL-6 production and inducible nitric oxide synthase (iNOS expression by activated microglia without affecting cyclooxygenase-2 (COX-2 expression and phagocytosis. Oral treatment of mice with diazoxide ameliorated EAE clinical signs but did not prevent disease. Histological analysis demonstrated that diazoxide elicited a significant reduction in myelin and axonal loss accompanied by a decrease in glial activation and neuronal damage. Diazoxide did not affect the number of infiltrating lymphocytes positive for CD3 and CD20

  7. Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC).

    Science.gov (United States)

    Sheldon, Kely L; Gurnev, Philip A; Bezrukov, Sergey M; Sackett, Dan L

    2015-10-30

    It was previously shown that tubulin dimer interaction with the mitochondrial outer membrane protein voltage-dependent anion channel (VDAC) blocks traffic through the channel and reduces oxidative metabolism and that this requires the unstructured anionic C-terminal tail peptides found on both α- and β-tubulin subunits. It was unclear whether the α- and β-tubulin tails contribute equally to VDAC blockade and what effects might be due to sequence variations in these tail peptides or to tubulin post-translational modifications, which mostly occur on the tails. The nature of the contribution of the tubulin body beyond acting as an anchor for the tails had not been clarified either. Here we present peptide-protein chimeras to address these questions. These constructs allow us to easily combine a tail peptide with different proteins or combine different tail peptides with a particular protein. The results show that a single tail grafted to an inert protein is sufficient to produce channel closure similar to that observed with tubulin. We show that the β-tail is more than an order of magnitude more potent than the α-tail and that the lower α-tail activity is largely due to the presence of a terminal tyrosine. Detyrosination activates the α-tail, and activation is reversed by the removal of the glutamic acid penultimate to the tyrosine. Nitration of tyrosine reverses the tyrosine inhibition of binding and even induces prolonged VDAC closures. Our results demonstrate that small changes in sequence or post-translational modification of the unstructured tails of tubulin result in substantial changes in VDAC closure. PMID:26306046

  8. Direct numerical simulation of free convection in a vertical channel: a tool for second moment closure modeling

    International Nuclear Information System (INIS)

    Natural turbulent convection in a differentially heated infinite vertical slot is computed with a mixed finite differences/Fourier code. At a Rayleigh number of 105, periodic perturbations from the laminar solution develop and transition to a fully turbulent flow occurs. From then on, a database of high order correlations is constituted and used for testing a second moment closure based on the LRR model and elliptic relaxation near wall effects. Counter gradient turbulent transport, found in the central part of the channel, requires an algebraic model for the triple correlations instead of the standard DH or HL, gradient diffusion models. (authors). 18 refs., 14 figs., 1 tab

  9. KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

    DEFF Research Database (Denmark)

    Aaboe, Kasper; Knop, Filip Krag; Vilsboll, Tina; Vølund, Aage; Simonsen, Ulf; Deacon, Carolyn F.; Madsbad, Sten; Holst, Jens Juul; Krarup, Thure

    2008-01-01

    using a 2-h (15 mM) hyperglycemic clamp on 4 separate days with concomitant infusion of one of the following: GIP; GIP + 10 mg sulfonylurea (SU, glipizide) taken orally 1 h before the clamp; saline + 10 mg SU; or saline alone. Blood was sampled to measure plasma concentrations of glucose, intact GIP...

  10. Molecular mechanism for depolarization-induced modulation of Kv channel closure

    OpenAIRE

    Labro, Alain J.; Lacroix, Jerome J.; Villalba-Galea, Carlos A.; Snyders, Dirk J.; Bezanilla, Francisco

    2012-01-01

    Voltage-dependent potassium (Kv) channels provide the repolarizing power that shapes the action potential duration and helps control the firing frequency of neurons. The K+ permeation through the channel pore is controlled by an intracellularly located bundle-crossing (BC) gate that communicates with the voltage-sensing domains (VSDs). During prolonged membrane depolarizations, most Kv channels display C-type inactivation that halts K+ conduction through constriction of the K+ selectivity fil...

  11. Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats.

    Science.gov (United States)

    Yang, Fan; Zhou, Li; Wang, Dong; Yang, Li-Li; Yuan, Guo-Rong; Huang, Qing-Yuan

    2016-01-01

    The phenomenon of water intake reduction during the 1(st) day of hypobaric hypoxia has been known for a long time. However, the reason for the same is yet unknown. The transient receptor potential vanilloid (TRPV) channels, including TRPV1 and TRPV4, are located in the subfornical organ (SFO). These are calcium permeable cationic channels gated by various stimuli such as cell swelling, low pH, and high temperature, and participate in anti-dipsogenic effects when activated. We aimed to explore the drinking behavior of rats and the mechanism of TRPVs under hypoxia. Chemical TRPV4 inhibitors (HC-067047 and Gadolinium) or TRPV4 knockout, but not TRPV1 inhibitor SB-705498, could restore the water intake under hypoxia. Hypoxia-mediated direct activation of TRPV4 may be the reason of anti-dipsogenic effects because the serum sodium, pH, and intracranial temperature are unaltered. Interestingly, we found that hypoxia immediately increased the intracellular Ca(2+) concentration ([Ca(2+)]i) in HEK293-TRPV4 cells and primary neurons from SFO region, but not in the HEK293-TRPV1 cells. Moreover, hypoxia-induced [Ca(2+)]i increase depended on the indispensable hemeoxygenase-2 (HO-2) and TRPV4. HO-2 and TRPV4 were also confirmed to form a complex in SFO neurons. These results demonstrated that SFO cells sense hypoxia and activate via the HO-2/TRPV4 multiple channels, which are associated with anti-dipsogenic effects. PMID:27436489

  12. Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis.

    Science.gov (United States)

    Zhang, Ying; Zhao, Xin; Chang, Yanzhong; Zhang, Yuanyuan; Chu, Xi; Zhang, Xuan; Liu, Zhenyi; Guo, Hui; Wang, Na; Gao, Yonggang; Zhang, Jianping; Chu, Li

    2016-06-15

    Liver fibrosis is the principal cause of morbidity and mortality in patients with iron overload. Calcium channel blockers (CCBs) can antagonize divalent cation entry into renal and myocardial cells and inhibit fibrogenic gene expression. We investigated the potential of CCBs to resolve iron overload-associated hepatic fibrosis. Kunming mice were assigned to nine groups (n=8 per group): control, iron overload, deferoxamine, high and low dose verapamil, high and low dose nimodipine, and high and low dose diltiazem. Iron deposition and hepatic fibrosis were measured in mouse livers. Expression levels of molecules associated with transmembrane iron transport were determined by molecular biology approaches. In vitro HSC-T6 cells were randomized into nine groups (the same groups as the mice). Changes in proliferation, apoptosis, and metalloproteinase expression in cells were detected to assess the anti-fibrotic effects of CCBs during iron overload conditions. We found that CCBs reduced hepatic iron content, intracellular iron deposition, the number of hepatic fibrotic areas, collagen expression levels, and hydroxyproline content. CCBs rescued abnormal expression of α1C protein in L-type voltage-dependent calcium channel (LVDCC) and down-regulated divalent metal transporter-1 (DMT-1) expression in mouse livers. In iron-overloaded HSC-T6 cells, CCBs reduced iron deposition, inhibited proliferation, induced apoptosis, and elevated expression of matrix metalloproteinase-13 (MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1). CCBs are potential therapeutic agents that can be used to address hepatic fibrosis during iron overload. They resolve hepatic fibrosis probably correlated with regulating transmembrane iron transport and inhibiting HSC growth. PMID:27095094

  13. Direct numerical simulation of natural convection in a vertical channel: a tool for second moment closure modeling

    International Nuclear Information System (INIS)

    Natural turbulent convection in a differentially heated infinite vertical slot is computed with a mixed finite differences/Fourier code. At a Rayleigh number of 105, in the case without mean stratification, periodic perturbations from the laminar solution develop and transition to a fully turbulent flow occurs. From then on, a database of one-point statistics is presented: mean velocity and temperature, Reynolds stress components, turbulent heat fluxes and variance of temperature, but also budgets of second moment equations. This database is then used for testing of a second moment closure based on the Launder-Reece-Rodi model on an elliptic relaxation for near wall effects on pressure redistribution. This level of modelling is required by the presence of counter gradient fluxes, which cannot be accounted for eddy viscosity and eddy diffusivity assumptions. Furthermore, an algebraic third order moment closure was found necessary because of counter gradient turbulent transport terms which appear to mainly originate from the mean velocity and temperature gradient terms usually neglected in conventional transport models, such as the standard Daly-Harlow or Hanjalic-Launder models. (authors)

  14. K-ATP Channel Closure Ameliorates the Impaired Insulinotropic Effect of Glucose-Dependent Insulinotropic Polypeptide in Patients with Type 2 Diabetes

    DEFF Research Database (Denmark)

    Aaboe, K.; Knop, K.; Vilsboll, T.; Volund, A.; Simonsen, U.; Deacon, C.F.; Madsbad, S.; Holst, J.J.; Krarup, T.

    2009-01-01

    using a 2-h (15 mM) hyperglycemic clamp on 4 separate days with concomitant infusion of one of the following: GIP; GIP + 10 mg sulfonylurea (SU, glipizide) taken orally 1 h before the clamp; saline + 10 mg SU; or saline alone. Blood was sampled to measure plasma concentrations of glucose, intact GIP...

  15. Modulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats.

    Directory of Open Access Journals (Sweden)

    Xin Zhou

    Full Text Available BACKGROUND: Emerging evidence shows that anti-inflammatory strategies targeting inflammatory monocyte subset could reduce excessive inflammation and improve cardiovascular outcomes. Functional expression of voltage-gated sodium channels (VGSCs have been demonstrated in monocytes and macrophages. We hypothesized that mononuclear phagocyte VGSCs are a target for monocyte/macrophage phenotypic switch, and liposome mediated inhibition of mononuclear phagocyte VGSC may attenuate myocardial ischemia/reperfusion (I/R injury and improve post-infarction left ventricular remodeling. METHODOLOGY/PRINCIPAL FINDINGS: Thin film dispersion method was used to prepare phenytoin (PHT, a non-selective VGSC inhibitor entrapped liposomes. Pharmacokinetic study revealed that the distribution and elimination half-life of PHT entrapped liposomes were shorter than those of free PHT, indicating a rapid uptake by mononuclear phagocytes after intravenous injection. In rat peritoneal macrophages, several VGSC α subunits (NaV1.1, NaV1.3, NaV1.4, NaV1.5, NaV1.6, NaV1.7, NaVX, Scn1b, Scn3b and Scn4b and β subunits were expressed at mRNA level, and PHT could suppress lipopolysaccharide induced M1 polarization (decreased TNF-α and CCL5 expression and facilitate interleukin-4 induced M2 polarization (increased Arg1 and TGF-β1 expression. In vivo study using rat model of myocardial I/R injury, demonstrated that PHT entrapped liposome could partially suppress I/R injury induced CD43+ inflammatory monocyte expansion, along with decreased infarct size and left ventricular fibrosis. Transthoracic echocardiography and invasive hemodynamic analysis revealed that PHT entrapped liposome treatment could attenuate left ventricular structural and functional remodeling, as shown by increased ejection fraction, reduced end-systolic and end-diastolic volume, as well as an amelioration of left ventricular systolic (+dP/dt max and diastolic (-dP/dt min functions. CONCLUSIONS/SIGNIFICANCE: Our

  16. Closure of multiple types of K+ channels is necessar to induce changes in renal vascular resistance in vivo in rats

    DEFF Research Database (Denmark)

    Sørensen, Charlotte Mehlin; Giese, Isaiah; Braunstein, Thomas Hartig;

    2011-01-01

    flow (RBF) in vivo in anesthetized Sprague-Dawley rats. Test agents were infused directly into the renal artery to avoid systemic effects. Inhibition of BK(Ca) and K(ir) channels (with TEA and Ba(2+), respectively) caused small and transient reductions in RBF (to 93¿±¿2% and 95¿±¿1% of baseline...

  17. On development of analytical closure relationships for local wall friction, heat and mass transfer coefficients for sub-channel codes

    International Nuclear Information System (INIS)

    The purpose has been to describe an approach suggested for constructing generalized closure relationships for local and subchannel wall friction, heat and mass transfer coefficients, with not only axial and transversal parameters taken into account, but azimuthal substance transfer effects as well. These constitutive relations that are primary for description of one- and two-phase one-dimensional flow models can be derived from the initial 3-D drift flux formulation. The approach is based on the Reynolds flux, boundary layer and generalized coefficient of substance transfer. One more task has been to illustrate the validity of the 'conformity principle' for the limiting cases. The method proposed is based on the similarity theory, boundary layer model, and a phenomenological description of the regularities of the substance transfer (momentum, heat, and mass), as well as on an adequate simulation of the forms of flow structure by a generalized approach to build (an integrated in form and semi-empirical in maintenance structure) analytical relationships for wall friction, heat and mass transfer coefficients. (author)

  18. Uplifted ophiolitic rocks on Isla Gordon, southernmost Chile: implications for the closure history of the Rocas Verdes marginal basin and the tectonic evolution of the Beagle Channel region

    Science.gov (United States)

    Cunningham, W. D.

    1994-04-01

    A succession of mafic rocks that includes gabbro, sheeted dikes and deformed pillow basalts has been mapped in detail on Isla Gordon, southernmost Chile and is identified as an upper ophiolitic complex representing the uplifted floor of the Late Jurassic-Early Cretaceous Rocas Verdes marginal basin. The complex was uplifted, deformed, and regionally metamorphosed prior to the intrusion of an undeformed 90 Ma granodiorite that cuts the complex. The complex appears para-autochthonous, is gently tilted to the northeast and is internally sheared by near-vertical foliation zones. No evidence for obduction was observed although the base of the complex is not exposed. The ophiolitic rocks have been regionally metamorphosed to mid-upper greenschist levels. Isla Gordon is bounded by the northwest and southwest arms of the Beagle Channel, two important structural boundaries in the southernmost Andes that are interpreted to have accommodated north-side-up and left-lateral displacements. Directly north of Isla Gordon is the Cordillera Darwin metamorphic complex that exposes the highest grade metamorphic rocks in the Andes south of Peru. On the north coast of Isla Gordon a volcaniclastic turbidite sequence that is interpreted to have been deposited above the mafic floor is metamorphosed to lower greenschist levels in strong metamorphic contrast to amphibolite-grade othogneisses exposed in Cordillera Darwin only 2 km away across the northwest arm of the Beagle Channel. The profound metamorphic break across the northwest arm of the Beagle Channel and the regional northeast tilt of the ophiolitic complex are consistent with the previously proposed hypothesis that Isla Gordon represents the upper plate to an extensional fault that accommodated tectonic unroofing of Cordillera Darwin. However, limited structural evidence for extension was identified in this study to support the model and further work is needed to determine the relative importance of contractional, extensional and

  19. Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons.

    Science.gov (United States)

    Khodr, Christina E; Chen, Lihua; Dave, Sonya; Al-Harthi, Lena; Hu, Xiu-Ti

    2016-10-01

    Human Immunodeficiency Virus type 1 (HIV-1) infection induces neurological and neuropsychological deficits, which are associated with dysregulation of the medial prefrontal cortex (mPFC) and other vulnerable brain regions. We evaluated the impact of HIV infection in the mPFC and the therapeutic potential of targeting over-active voltage-gated L-type Ca(2+) channels (L-channel) and NMDA receptors (NMDAR), as modeled in HIV-1 transgenic (Tg) rats. Whole-cell patch-clamp recording was used to assess the membrane properties and voltage-sensitive Ca(2+) potentials (Ca(2+) influx) in mPFC pyramidal neurons. Neurons from HIV-1 Tg rats displayed reduced rheobase, spike amplitude and inwardly-rectifying K(+) influx, increased numbers of action potentials, and a trend of aberrant firing compared to those from non-Tg control rats. Neuronal hyper-excitation was associated with abnormally-enhanced Ca(2+) influx (independent of NMDAR), which was eliminated by acute L-channel blockade. Combined chronic blockade of over-active L-channels and NMDARs with open-channel blockers abolished HIV effects on spiking, aberrant firing and Ca(2+) potential half-amplitude duration, though not the reduced inward rectification. In contrast, individual chronic blockade of over-active L-channels or NMDARs did not alleviate HIV-induced mPFC hyper-excitability. These studies demonstrate that HIV alters mPFC neuronal activity by dysregulating membrane excitability and Ca(2+) influx through the L-channels. This renders these neurons more susceptible and vulnerable to excitatory stimuli, and could contribute to HIV-associated neuropathogenesis. Combined targeting of over-active L-channels/NMDARs alleviates HIV-induced dysfunction of mPFC pyramidal neurons, emphasizing a potential novel therapeutic strategy that may effectively decrease HIV-induced Ca(2+) dysregulation in the mPFC. PMID:27326669

  20. Restaurant closures

    CERN Multimedia

    Novae Restauration

    2012-01-01

    Christmas Restaurant closures Please note that the Restaurant 1 and Restaurant 3 will be closed from Friday, 21 December at 5 p.m. to Sunday, 6 January, inclusive. They will reopen on Monday, 7 January 2013.   Restaurant 2 closure for renovation To meet greater demand and to modernize its infrastructure, Restaurant 2 will be closed from Monday, 17 December. On Monday, 14 January 2013, Sophie Vuetaz’s team will welcome you to a renovated self-service area on the 1st floor. The selections on the ground floor will also be expanded to include pasta and pizza, as well as snacks to eat in or take away. To ensure a continuity of service, we suggest you take your break at Restaurant 1 or Restaurant 3 (Prévessin).

  1. 螺纹锁紧环热交换器管箱端部弹塑性分析及优化%Elastic-plastic Analysis and Optimization for the Tube Channel End of Breech Lock Closure Type Heat Exchanger

    Institute of Scientific and Technical Information of China (English)

    徐雪倩; 陈平

    2015-01-01

    An axisymmetric plane model about the tube channel end of a breech lock closure type heat exchanger was established by using the finite element software ANSYS.Both of the elastic and elastic-plastic analyses were conducted.The changing rules of the stress distribution at the root of screw threads and the contact pressure on screw threads engagement surfaces are discussed.In addition,an optimiza-tion design based on the elastic model for this structure was also carried out in order to determine a rea-sonable structure size,as well as to make use of materials more efficiently.%借助 ANSYS 建立某螺纹锁紧环热交换器端部的轴对称平面模型,对其进行弹性和弹塑性应力分析,得到了螺纹根部应力和螺纹啮合面上接触压力的变化规律。利用弹性分析模型对该端部结构进行优化设计,确定了实例结构的合理尺寸,使材料得到更有效的利用。

  2. Closure Operators and Closure Systems on Quantaloid-Enriched Categories

    Institute of Scientific and Technical Information of China (English)

    Min LIU; Bin ZHAO

    2013-01-01

    In this paper,we introduce the fundamental notions of closure operator and closure system in the framework of quantaloid-enriched category.We mainly discuss the relationship between closure operators and adjunctions and establish the one-to-one correspondence between closure operators and closure systems on quantaloid-enriched categories.

  3. Closure for a container

    International Nuclear Information System (INIS)

    A container for radioactive or other hazardous materials has a conical-shaped closure containing grooves in the conical surface thereof and an O-ring seal incorporated in each of such grooves. The closure is kept in place by a stopper. (author)

  4. Eyelid closure at death

    Directory of Open Access Journals (Sweden)

    A D Macleod

    2009-01-01

    Full Text Available Aim: To observe the incidence of full or partial eyelid closure at death. Materials and Methods: The presence of ptosis was recorded in 100 consecutive hospice patient deaths. Results: Majority (63% of the patients died with their eyes fully closed, however, 37% had bilateral ptosis at death, with incomplete eye closure. In this study, central nervous system tumor involvement and/or acute hepatic encephalopathy appeared to be pre-mortem risk factors of bilateral ptosis at death. Conclusion: Organicity and not psychogenicity is, therefore, the likely etiology of failure of full eyelid closure at death.

  5. Means for limiting and ameliorating electrode shorting

    Energy Technology Data Exchange (ETDEWEB)

    Konynenburg, R.A. van; Farmer, J.C.

    1999-11-09

    A fuse and filter arrangement is described for limiting and ameliorating electrode shorting in capacitive deionization water purification systems utilizing carbon aerogel, for example. This arrangement limits and ameliorates the effects of conducting particles or debonded carbon aerogel in shorting the electrodes of a system such as a capacitive deionization water purification system. This is important because of the small interelectrode spacing and the finite possibility of debonding or fragmentation of carbon aerogel in a large system. The fuse and filter arrangement electrically protect the entire system from shutting down if a single pair of electrodes is shorted and mechanically prevents a conducting particle from migrating through the electrode stack, shorting a series of electrode pairs in sequence. It also limits the amount of energy released in a shorting event. The arrangement consists of a set of circuit breakers or fuses with one fuse or breaker in the power line connected to one electrode of each electrode pair and a set of screens of filters in the water flow channels between each set of electrode pairs.

  6. Means for limiting and ameliorating electrode shorting

    Energy Technology Data Exchange (ETDEWEB)

    Van Konynenburg, Richard A. (Livermore, CA); Farmer, Joseph C. (Tracy, CA)

    1999-01-01

    A fuse and filter arrangement for limiting and ameliorating electrode shorting in capacitive deionization water purification systems utilizing carbon aerogel, for example. This arrangement limits and ameliorates the effects of conducting particles or debonded carbon aerogel in shorting the electrodes of a system such as a capacitive deionization water purification system. This is important because of the small interelectrode spacing and the finite possibility of debonding or fragmentation of carbon aerogel in a large system. The fuse and filter arrangement electrically protect the entire system from shutting down if a single pair of electrodes is shorted and mechanically prevents a conducting particle from migrating through the electrode stack, shorting a series of electrode pairs in sequence. It also limits the amount of energy released in a shorting event. The arrangement consists of a set of circuit breakers or fuses with one fuse or breaker in the power line connected to one electrode of each electrode pair and a set of screens of filters in the water flow channels between each set of electrode pairs.

  7. Nitric oxide, stomatal closure, and abiotic stress.

    Science.gov (United States)

    Neill, Steven; Barros, Raimundo; Bright, Jo; Desikan, Radhika; Hancock, John; Harrison, Judith; Morris, Peter; Ribeiro, Dimas; Wilson, Ian

    2008-01-01

    Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli. Experimental evidence in support of such signalling roles for NO has been obtained via the application of NO, usually in the form of NO donors, via the measurement of endogenous NO, and through the manipulation of endogenous NO content by chemical and genetic means. Stomatal closure, initiated by abscisic acid (ABA), is effected through a complex symphony of intracellular signalling in which NO appears to be one component. Exogenous NO induces stomatal closure, ABA triggers NO generation, removal of NO by scavengers inhibits stomatal closure in response to ABA, and ABA-induced stomatal closure is reduced in mutants that are impaired in NO generation. The data indicate that ABA-induced guard cell NO generation requires both nitric oxide synthase-like activity and, in Arabidopsis, the NIA1 isoform of nitrate reductase (NR). NO stimulates mitogen-activated protein kinase (MAPK) activity and cGMP production. Both these NO-stimulated events are required for ABA-induced stomatal closure. ABA also stimulates the generation of H2O2 in guard cells, and pharmacological and genetic data demonstrate that NO accumulation in these cells is dependent on such production. Recent data have extended this model to maize mesophyll cells where the induction of antioxidant defences by water stress and ABA required the generation of H2O2 and NO and the activation of a MAPK. Published data suggest that drought and salinity induce NO generation which activates cellular processes that afford some protection against the oxidative stress associated with these conditions. Exogenous NO can also protect cells against oxidative stress. Thus, the data suggest an emerging model of stress responses in which ABA has several ameliorative functions. These include the rapid induction of stomatal closure to reduce transpirational water loss and the activation of antioxidant defences

  8. Specialization and Integral Closure

    OpenAIRE

    Hong, J.; Ulrich, B.

    2006-01-01

    We prove that the integral closedness of any ideal of height at least two is compatible with specialization by a generic element. This opens the possibility for proofs using induction on the height of an ideal. Also, with additional assumptions, we show that an element is integral over a module if it is integral modulo a generic element of the module. This turns questions about integral closures of modules into problems about integral closures of ideals, by means of a construction known as Bo...

  9. Tubular closure mechanism

    International Nuclear Information System (INIS)

    This invention relates to a closure mechanism for tubular irradiation surveillance specimen assembly holder used in nuclear reactors. The closure mechanism is composed of a latching member which includes a generally circular chamber with a plurality of elongated latches depending therefrom. The latching member circumscribes part of an actuator member which is disposed within the latching member so as to be axially movable. The axial movement of the actuator actuates positioning of the latches between positions in which the latches are locked and secured within the actuator member. Means, capable of being remotely manipulated, are provided to move the actuator in order to position the latches and load the articles within the tube

  10. Tank closure reducing grout

    Energy Technology Data Exchange (ETDEWEB)

    Caldwell, T.B.

    1997-04-18

    A reducing grout has been developed for closing high level waste tanks at the Savannah River Site in Aiken, South Carolina. The grout has a low redox potential, which minimizes the mobility of Sr{sup 90}, the radionuclide with the highest dose potential after closure. The grout also has a high pH which reduces the solubility of the plutonium isotopes. The grout has a high compressive strength and low permeability, which enhances its ability to limit the migration of contaminants after closure. The grout was designed and tested by Construction Technology Laboratories, Inc. Placement methods were developed by the Savannah River Site personnel.

  11. Tank closure reducing grout

    International Nuclear Information System (INIS)

    A reducing grout has been developed for closing high level waste tanks at the Savannah River Site in Aiken, South Carolina. The grout has a low redox potential, which minimizes the mobility of Sr90, the radionuclide with the highest dose potential after closure. The grout also has a high pH which reduces the solubility of the plutonium isotopes. The grout has a high compressive strength and low permeability, which enhances its ability to limit the migration of contaminants after closure. The grout was designed and tested by Construction Technology Laboratories, Inc. Placement methods were developed by the Savannah River Site personnel

  12. Mail Office annual closure

    CERN Multimedia

    2013-01-01

    On the occasion of the annual closure of CERN, there will be no mail distributed on Friday 20 December 2013 but mail will be collected in the morning. Nevertheless, you will still be able to bring your outgoing mail to Building 555-R-002 until 12 noon.  

  13. Summer season | Cafeteria closures

    CERN Multimedia

    2013-01-01

    Please note the following cafeteria closures over the summer season: Bldg. 54 closed from 29/07/2013 to 06/09/2013. Bldg. 13: closed from 13/07/2013 to 06/09/2013. Restaurant No. 2, table service (brasserie and restaurant): closed from 01/08/2013 to 06/09/2013. Bldg. 864: closed from 29/07/2013 to 06/09/2013. Bldg. 865: closed from 29/07/2013 to 06/09/2013.

  14. Nevada Test Site closure program

    International Nuclear Information System (INIS)

    This report is a summary of the history, design and development, procurement, fabrication, installation and operation of the closures used as containment devices on underground nuclear tests at the Nevada Test Site. It also addresses the closure program mothball and start-up procedures. The Closure Program Document Index and equipment inventories, included as appendices, serve as location directories for future document reference and equipment use

  15. Assisted closure of fasciotomy wounds

    OpenAIRE

    Fowler, J. R.; Kleiner, M. T.; Das, R.; Gaughan, J.P.; Rehman, S.

    2012-01-01

    Introduction Negative pressure wound therapy (NPWT) and vessel loop assisted closure are two common methods used to assist with the closure of fasciotomy wounds. This retrospective review compares these two methods using a primary outcome measurement of skin graft requirement. Methods A retrospective search was performed to identify patients who underwent fasciotomy at our institution. Patient demographics, location of the fasciotomy, type of assisted closure, injury characteristics, need for...

  16. Nevada Test Site closure program

    Energy Technology Data Exchange (ETDEWEB)

    Shenk, D.P.

    1994-08-01

    This report is a summary of the history, design and development, procurement, fabrication, installation and operation of the closures used as containment devices on underground nuclear tests at the Nevada Test Site. It also addresses the closure program mothball and start-up procedures. The Closure Program Document Index and equipment inventories, included as appendices, serve as location directories for future document reference and equipment use.

  17. System for closure of a physical anomaly

    Energy Technology Data Exchange (ETDEWEB)

    Bearinger, Jane P; Maitland, Duncan J; Schumann, Daniel L; Wilson, Thomas S

    2014-11-11

    Systems for closure of a physical anomaly. Closure is accomplished by a closure body with an exterior surface. The exterior surface contacts the opening of the anomaly and closes the anomaly. The closure body has a primary shape for closing the anomaly and a secondary shape for being positioned in the physical anomaly. The closure body preferably comprises a shape memory polymer.

  18. FINAL CLOSURE PLAN SURFACE IMPOUNDMENTS CLOSURE, SITE 300

    Energy Technology Data Exchange (ETDEWEB)

    Lane, J E; Scott, J E; Mathews, S E

    2004-09-29

    Lawrence Livermore National Laboratory of the University of California (LLNL) operates two Class II surface impoundments that store wastewater that is discharged from a number of buildings located on the Site 300 Facility (Site 300). The wastewater is the by-product of explosives processing. Reduction in the volume of water discharged from these buildings over the past several years has significantly reduced the wastewater storage needs. In addition, the impoundments were constructed in 1984, and the high-density polyethylene (HDPE) geomembrane liners are nearing the end of their service life. The purpose of this project is to clean close the surface impoundments and provide new wastewater storage using portable, above ground storage tanks at six locations. The tanks will be installed prior to closure of the impoundments and will include heaters for allowing evaporation during relatively cool weather. Golder Associates (Golder) has prepared this Final Closure Plan (Closure Plan) on behalf of LLNL to address construction associated with the clean closure of the impoundments. This Closure Plan complies with State Water Resources Control Board (SWRCB) Section 21400 of the California Code of Regulations Title 27 (27 CCR {section}21400). As required by these regulations and guidance, this Plan provides the following information: (1) A site characterization, including the site location, history, current operations, and geology and hydrogeology; (2) The regulatory requirements relevant to clean closure of the impoundments; (3) The closure procedures; and, (4) The procedures for validation and documentation of clean closure.

  19. Tight closure and vanishing theorems

    International Nuclear Information System (INIS)

    Tight closure has become a thriving branch of commutative algebra since it was first introduced by Mel Hochster and Craig Huneke in 1986. Over the past few years, it has become increasingly clear that tight closure has deep connections with complex algebraic geometry as well, especially with those areas of algebraic geometry where vanishing theorems play a starring role. The purpose of these lectures is to introduce tight closure and to explain some of these connections with algebraic geometry. Tight closure is basically a technique for harnessing the power of the Frobenius map. The use of the Frobenius map to prove theorems about complex algebraic varieties is a familiar technique in algebraic geometry, so it should perhaps come as no surprise that tight closure is applicable to algebraic geometry. On the other hand, it seems that so far we are only seeing the tip of a large and very beautiful iceberg in terms of tight closure's interpretation and applications to algebraic geometry. Interestingly, although tight closure is a 'characteristic p' tool, many of the problems where tight closure has proved useful have also yielded to analytic (L2) techniques. Despite some striking parallels, there had been no specific result directly linking tight closure and L∼ techniques. Recently, however, the equivalence of an ideal central to the theory of tight closure was shown to be equivalent to a certain 'multiplier ideal' first defined using L2 methods. Presumably, deeper connections will continue to emerge. There are two main types of problems for which tight closure has been helpful: in identifying nice structure and in establishing uniform behavior. The original algebraic applications of tight closure include, for example, a quick proof of the Hochster-Roberts theorem on the Cohen-Macaulayness of rings of invariants, and also a refined version of the Brianqon-Skoda theorem on the uniform behaviour of integral closures of powers of ideals. More recent, geometric

  20. Closedure - Mine Closure Technologies Resource

    Science.gov (United States)

    Kauppila, Päivi; Kauppila, Tommi; Pasanen, Antti; Backnäs, Soile; Liisa Räisänen, Marja; Turunen, Kaisa; Karlsson, Teemu; Solismaa, Lauri; Hentinen, Kimmo

    2015-04-01

    Closure of mining operations is an essential part of the development of eco-efficient mining and the Green Mining concept in Finland to reduce the environmental footprint of mining. Closedure is a 2-year joint research project between Geological Survey of Finland and Technical Research Centre of Finland that aims at developing accessible tools and resources for planning, executing and monitoring mine closure. The main outcome of the Closedure project is an updatable wiki technology-based internet platform (http://mineclosure.gtk.fi) in which comprehensive guidance on the mine closure is provided and main methods and technologies related to mine closure are evaluated. Closedure also provides new data on the key issues of mine closure, such as performance of passive water treatment in Finland, applicability of test methods for evaluating cover structures for mining wastes, prediction of water effluents from mine wastes, and isotopic and geophysical methods to recognize contaminant transport paths in crystalline bedrock.

  1. Friction or Closure

    DEFF Research Database (Denmark)

    Lundahl, Mikela

    2014-01-01

    of Stone Town, Zan-zibar? It is a place of beauty and violence, of trade, slavery and tourism, and the World Heritage narrative does not accommodate all its significant historical facts and lived memories. In this article I will discuss some of these conflicting or competing historical facts. The...... Stone Town in Zanzibar and the de-velopment and dissolution going on under the shadow of the UNESCO World Heritage flag; a growing tourism; a global and local increase in islamisation; and the political tension within the Tanzanian union. My main focus is narratives of the identity of Zanzibar since......Heritage is a discourse that aims at closure. It fixates the narrative of the past through the celebration of specific material (or sometimes immaterial non-) ob-jects. It organizes temporality and construct events and freezes time. How does this unfold in the case of the UNESCO World Heritage site...

  2. MNC Subsidiary Closures

    DEFF Research Database (Denmark)

    Sofka, Wolfgang; Torres Preto, Miguel; de Faria, Pedro

    2014-01-01

    highly productive by host-country standards), and lower wages when signals indicate that potential employees have highly MNC-specific human capital (e.g., the employee had a long tenure in the closed subsidiary). We provide empirical evidence based on a sample of 110,133 displaced employees of closed MNC......We investigate the consequences of MNC subsidiary closures for employees who lose their jobs. In particular, we examine the extent to which the human capital that these employees acquired while employed by the MNC influences the wages they receive in their new jobs. We propose an employee...... displacement model for foreign MNC subsidiaries that integrates insights from the labor economics and international business literatures. We argue that a new employer will pay higher wages when signals indicate that potential employees have valuable, foreign human capital (e.g., the closed subsidiary was...

  3. Effectiveness of percutaneous closure of patent foramen ovale for hypoxemia.

    Science.gov (United States)

    Fenster, Brett E; Nguyen, Bryant H; Buckner, J Kern; Freeman, Andrew M; Carroll, John D

    2013-10-15

    The aim of this study was to evaluate the ability of percutaneous patent foramen ovale (PFO) closure to improve systemic hypoxemia. Although PFO-mediated right-to-left shunt (RTLS) is associated with hypoxemia, the ability of percutaneous closure to ameliorate hypoxemia is unknown. Between 2004 and 2009, 97 patients who underwent PFO closure for systemic hypoxemia and dyspnea that was disproportionate to underlying lung disease were included for evaluation. All patients exhibited PFO-mediated RTLS as determined by agitated saline echocardiography. Procedural success was defined as implantation of a device without major complications and mild or no residual shunt at 6 months. Clinical success was defined as a composite of an improvement in New York Heart Association (NYHA) functional class, reduction of dyspnea symptoms, or decreased oxygen requirement. Procedural success was achieved in 96 of 97 (99%), and clinical success was achieved in 68 of 97 (70%). The presence of any moderate or severe interatrial shunt by agitated saline study (odds ratio [OR] = 4.7; p RTLS, NYHA functional class, and oxygen requirement. PMID:23871675

  4. Closure report for N Reactor

    International Nuclear Information System (INIS)

    This report has been prepared to satisfy Section 3156(b) of Public Law 101-189 (Reports in Connection with Permanent Closures of Department of Energy Defense Nuclear Facilities), which requires submittal of a Closure Report to Congress by the Secretary of Energy upon the permanent cessation of production operations at a US Department of Energy (DOE) defense nuclear facility (Watkins 1991). This closure report provides: (1) A complete survey of the environmental problems at the facility; (2) Budget quality data indicating the cost of environmental restoration and other remediation and cleanup efforts at the facility; (3) A proposed cleanup schedule

  5. Study of turbine with side channel runner

    OpenAIRE

    Jandourek, Pavel

    2012-01-01

    This thesis deals with proposal of constructional solving turbine with side channel. Basis for the design is lossy characteristics of the valve. The intention is to replace hydraulic closures by turbine with side channel runner. Hydraulic losses in the flow restriction in turn replaced by the electricity generation in the comparable characteristics of valve and turbine.

  6. Closure and Sealing Design Calculation

    Energy Technology Data Exchange (ETDEWEB)

    T. Lahnalampi; J. Case

    2005-08-26

    The purpose of the ''Closure and Sealing Design Calculation'' is to illustrate closure and sealing methods for sealing shafts, ramps, and identify boreholes that require sealing in order to limit the potential of water infiltration. In addition, this calculation will provide a description of the magma that can reduce the consequences of an igneous event intersecting the repository. This calculation will also include a listing of the project requirements related to closure and sealing. The scope of this calculation is to: summarize applicable project requirements and codes relating to backfilling nonemplacement openings, removal of uncommitted materials from the subsurface, installation of drip shields, and erecting monuments; compile an inventory of boreholes that are found in the area of the subsurface repository; describe the magma bulkhead feature and location; and include figures for the proposed shaft and ramp seals. The objective of this calculation is to: categorize the boreholes for sealing by depth and proximity to the subsurface repository; develop drawing figures which show the location and geometry for the magma bulkhead; include the shaft seal figures and a proposed construction sequence; and include the ramp seal figure and a proposed construction sequence. The intent of this closure and sealing calculation is to support the License Application by providing a description of the closure and sealing methods for the Safety Analysis Report. The closure and sealing calculation will also provide input for Post Closure Activities by describing the location of the magma bulkhead. This calculation is limited to describing the final configuration of the sealing and backfill systems for the underground area. The methods and procedures used to place the backfill and remove uncommitted materials (such as concrete) from the repository and detailed design of the magma bulkhead will be the subject of separate analyses or calculations. Post-closure

  7. Closure and Sealing Design Calculation

    International Nuclear Information System (INIS)

    The purpose of the ''Closure and Sealing Design Calculation'' is to illustrate closure and sealing methods for sealing shafts, ramps, and identify boreholes that require sealing in order to limit the potential of water infiltration. In addition, this calculation will provide a description of the magma that can reduce the consequences of an igneous event intersecting the repository. This calculation will also include a listing of the project requirements related to closure and sealing. The scope of this calculation is to: summarize applicable project requirements and codes relating to backfilling nonemplacement openings, removal of uncommitted materials from the subsurface, installation of drip shields, and erecting monuments; compile an inventory of boreholes that are found in the area of the subsurface repository; describe the magma bulkhead feature and location; and include figures for the proposed shaft and ramp seals. The objective of this calculation is to: categorize the boreholes for sealing by depth and proximity to the subsurface repository; develop drawing figures which show the location and geometry for the magma bulkhead; include the shaft seal figures and a proposed construction sequence; and include the ramp seal figure and a proposed construction sequence. The intent of this closure and sealing calculation is to support the License Application by providing a description of the closure and sealing methods for the Safety Analysis Report. The closure and sealing calculation will also provide input for Post Closure Activities by describing the location of the magma bulkhead. This calculation is limited to describing the final configuration of the sealing and backfill systems for the underground area. The methods and procedures used to place the backfill and remove uncommitted materials (such as concrete) from the repository and detailed design of the magma bulkhead will be the subject of separate analyses or calculations. Post-closure monitoring will not

  8. Reviewing post-closure issues

    International Nuclear Information System (INIS)

    The study of man-repository-interaction in the post-closure phase is a new field of research. Its evaluation must be based on a proper assessment of the predictive possibilities and limitations of the man-repository-system. Institutional controls would be a way of solving post-closure issues connected with retrievability, human intrusion and safeguards. Their predicted effectiveness is, however, limited to a few hundred years for active and to a few thousand years for passive controls. Therefore the much longer time periods of concern for geological repositories have to be taken into account. Answers to post-closure issues should be based on a rational evaluation of the good and bad aspects of alternative strategies and actions. Such an evaluation reveals tentative answers to post-closure issues. Retrievability: Repository construction and sealing in a way that renders institutional control unnecessary, but not impossible. Human intrusion: Emplacement of unavoidable hazardous waste in deep geological repositories is the best we can do today; alternatives like indefinite storage present higher risks and burdens on future generations. Safeguards: Safeguarding of nuclear material, if considered necessary by future generations, is possible with present day technology. Geological repositories will not enter into a post-closure status before the middle of the next century. Therefore post-closure issues present no urgent problem. (author). 27 refs, 2 tabs

  9. RCRA closure of mixed waste impoundments

    Energy Technology Data Exchange (ETDEWEB)

    Blaha, F.J. [Doty and Associates (United States); Greengard, T.C.; Arndt, M.B. [Rockwell International (United States)

    1989-11-01

    A case study of a RCRA closure action at the Rocky Flats Plant is presented. Closure of the solar evaporation ponds involves removal and immobilization of a mixed hazardous/radioactive sludge, treatment of impounded water, groundwater monitoring, plume delineation, and collection and treatment of contaminated groundwater. The site closure is described within the context of regulatory negotiations, project schedules, risk assessment, clean versus dirty closure, cleanup levels, and approval of closure plans and reports. Lessons learned at Rocky Flats are summarized.

  10. Ameliorating Effects of Sulfonylurea Drugs on Insulin Resistance in Otsuka Long-Evans Tokushima Fatty Rats

    OpenAIRE

    Park, Jeong-Kwon; Kim, Sang-Pyo; Song, Dae-Kyu

    2008-01-01

    OLETF (Otsuka Long-Evans Tokushima Fatty) rats are characterized by obesity-related insulin resistance, which is a phenotype of type 2 diabetes. Sulfonylurea drugs or benzoic acid derivatives as inhibitors of the ATP-sensitive potassium (KATP) channel are commercially available to treat diabetes. The present study compared sulfonylurea drugs (glimepiride and gliclazide) with one of benzoic acid derivatives (repaglinide) in regard to their long-term effect on ameliorating insulin sensitivity i...

  11. 100-D Ponds closure plan

    International Nuclear Information System (INIS)

    The 100-D Ponds is located within the Hanford Site and is a land surface impoundment for the disposal of liquid effluent. This unit has been classified as a Resource Conservation and Recovery Act of 1976 (RCRA) treatment, storage, and/or disposal (TSD) unit because of a potential for having received nonradioactive, regulated dangerous waste. These ponds are no longer being used to receive waste with a potential to be dangerous and so will be closed as a RCRA-regulated TSD unit consists of a Part A Permit Application (Revision 3) and a closure plan. The Part A Permit Application revisions are explained at the beginning of the Part A section. The closure plan presents a description of the 100-D Ponds structures and boundaries, the history of the waste managed, and the approach that will be followed to close the 100-0 Ponds TSD unit. Radionuclides (source, special nuclear, and by-product material) are not within the scope of WAC 173-303 or of this closure plan. The dangerous waste directly leading to the classification of the site as a RCRA TSD unit did not contain radioactive constituents. Information provided on radionuclides is only for general knowledge where appropriate. Only dangerous constituents derived from the 100-D Ponds operations are addressed in this closure plan

  12. Abdominal wound closure: current perspectives

    Directory of Open Access Journals (Sweden)

    Williams ZF

    2015-12-01

    Full Text Available Zachary F Williams, William W Hope Department of Surgery, South East Area Health Education Center, New Hanover Regional Medical Center, Wilmington, NC, USA Abstract: This review examines both early and late wound complications following laparotomy closure, with particular emphasis on technical aspects that reduce hernia formation. Abdominal fascial closure is an area of considerable variation within the field of general surgery. The formation of hernias following abdominal wall incisions continues to be a challenging problem. Ventral hernia repairs are among the most common surgeries performed by general surgeons, and despite many technical advances in the field, incisional hernia rates remain high. Much attention and research has been directed to the surgical management of hernias. Less focus has been placed on prevention of hernia formation despite its obvious importance. This review examines the effects of factors such as the type of incision, suture type and size, closure method, patient risk factors, and the use of prophylactic mesh. Keywords: incisional, abdominal, hernia, prevention, wound closure techniques 

  13. Telephone switchboard closure | 19 December

    CERN Multimedia

    2014-01-01

    Exceptionally, the telephone switchboard will close at 4 p.m. on Friday, 19 December, instead of the usual time of 6 p.m., to allow time for closing all systems properly before the annual closure. Therefore, switchboard operator assistance to transfer calls from/to external lines will stop. All other phone services will run as usual.

  14. 304 Concretion facility closure plan

    International Nuclear Information System (INIS)

    The Hanford Site, located northwest of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials. The 300 Area of the Hanford Site contains reactor fuel manufacturing facilities and several research and development laboratories. Recyclable scrap uranium Zircaloy-2 and copper silicon alloy, uranium-titanium alloy, beryllium/Zircaloy-2 alloy, and Zircaloy-2 chips and fines were secured in concrete billets in the 304 Concretion Facility, located in the 300 Area. The beryllium/Zircaloy-2 alloy and Zircaloy-2 chips and fines are designated as low-level radioactive mixed waste (LLRMW) with the characteristic of ignitability. The concretion process reduced the ignitability of the fines and chips for safe storage and shipment. This process has been discontinued and the 304 Concretion Facility is now undergoing closure as defined in the Resource Conservation and Recovery Act of 1976 (RCRA). This closure plan presents a description of the facility, the history of materials and wastes managed, and the procedures that will be followed to close the 304 Concretion Facility (304 Facility). Clean closure of the 304 Facility is the proposed method for closure of the facility. Justification for this proposal is presented. 15 refs., 22 figs., 4 tabs

  15. CIRSE Vascular Closure Device Registry

    International Nuclear Information System (INIS)

    Purpose: Vascular closure devices are routinely used after many vascular interventional radiology procedures. However, there have been no major multicenter studies to assess the safety and effectiveness of the routine use of closure devices in interventional radiology. Methods: The CIRSE registry of closure devices with an anchor and a plug started in January 2009 and ended in August 2009. A total of 1,107 patients were included in the registry. Results: Deployment success was 97.2%. Deployment failure specified to access type was 8.8% [95% confidence interval (95% CI) 5.0–14.5] for antegrade access and 1.8% (95% CI 1.1–2.9) for retrograde access (P = 0.001). There was no difference in deployment failure related to local PVD at the access site. Calcification was a reason for deployment failure in only 5.9 cm, and two vessel occlusions. Conclusion: The conclusion of this registry of closure devices with an anchor and a plug is that the use of this device in interventional radiology procedures is safe, with a low incidence of serious access site complications. There seems to be no difference in complications between antegrade and retrograde access and other parameters.

  16. Post-closure safety assessment

    International Nuclear Information System (INIS)

    This paper describes the approach under development by UK Nirex Ltd to assess the post-closure safety performance of a deep geological repository for radioactive waste. The term ''post-closure'' refers to the period following operation of the repository, when it has been filled with packaged wastes, backfilled and sealed. Assessment deals with the identification and modelling of the processes and pathways by which radionuclides from the repository may eventually return to the human environment. Post-closure performance assessment forms one element of the comprehensive case that must be developed by UK Nirex Ltd before a repository can be licensed and authorized for construction and operation. The paper outlines the demanding safety requirements for the post-closure period and indicates how they have played a significant part in the development of the Nirex disposal concept. Performance assessment makes extensive use of computer modelling. The models used to assess radionuclide migration from the underground repository to the surface environment are outlined. (author)

  17. 40 CFR 265.310 - Closure and post-closure care.

    Science.gov (United States)

    2010-07-01

    ... DISPOSAL FACILITIES Landfills § 265.310 Closure and post-closure care. (a) At final closure of the landfill or upon closure of any cell, the owner or operator must cover the landfill or cell with a final cover... landfill; (2) Function with minimum maintenance; (3) Promote drainage and minimize erosion or abrasion...

  18. 40 CFR 264.310 - Closure and post-closure care.

    Science.gov (United States)

    2010-07-01

    ... Landfills § 264.310 Closure and post-closure care. (a) At final closure of the landfill or upon closure of any cell, the owner or operator must cover the landfill or cell with a final cover designed and constructed to: (1) Provide long-term minimization of migration of liquids through the closed landfill;...

  19. Plant guard cell anion channel SLAC1 regulates stomatal closure

    OpenAIRE

    Vahisalu, Triin

    2010-01-01

    Plants are rooted to their growth place; therefore it is important that they react adequately to changes in environmental conditions. Stomatal pores, which are formed of a pair of guard cells in leaf epidermis, regulate plant gas-exchange. Importantly, guard cells protect the plant from desiccation in drought conditions by reducing the aperture of the stomatal pore. They serve also as the first barrier against the major air pollutant ozone, but the behaviour of guard cells during ozone expo...

  20. Foundations, trusts and funds in near mine closure and post-closure environments: a case from Bolivia

    DEFF Research Database (Denmark)

    Pacheco Cueva, Vladimir

    2012-01-01

    our understanding of FTF community empowerment and self-reliance in post closure environments. In other words, from the perspectives of community development and mine closure planning there is a case for documenting and evaluating FTFs operating at a time when company funds are no longer accessible......In the last three decades, an increasing number of mining and resources companies around the world have established community funds, trusts and foundations (FTFs) to comply with government legislation or as part of their social or philanthropic programmes. The growth of FTFs follows Corporate...... Social Responsibility trends within the resources sector to improve the way in which economic benefits are distributed among stakeholders. Benefit sharing mechanisms such as FTFs offer strategic channels by which companies can mobilise resources to mine affected communities. FTFs vary in structure...

  1. Stomatal closure by ultraviolet radiation

    International Nuclear Information System (INIS)

    The effect of ultraviolet radiation (UV) (255–325 nm) on stomatal closure was investigated on tef [Eragrostis tef (Zucc) Trotter] in the presence of white light (ca 50 ·mol m−2 s−1). The action spectrum showed that UV (ca 2 ·mol m−2 s−1, half band width about 10 nm) of 285 nm or shorter wavelengths was very efficient in causing stomatal closure. The effectiveness decreased sharply towards longer wavelengths. Radiation of 313 nm or longer wavelengths was practically without effect. Increasing UV intensity increased stomatal resistance. When stronger white light (5 to 9 times stronger than the one used during irradiation) was administered, stomates re-opened rapidly irrespective of whether the UV was on or off, although a subsequent gradual closing tendency was observed when the UV was on. (author)

  2. Reversing the indus basin closure

    OpenAIRE

    2011-01-01

    After independence, a swift and extensive development of Indus river basin has intensified commitment of water resources. During dry period, the indication of over commitment and basin closure are visible. In the beginning 2000s, he river basin water resources were committed to more than 99% without any environmental flows. The paper tries to unfold drivers closing the Indus basin and the scope for change. Defining and implementing water allocation mechanism to ascertain equity, sustainabilit...

  3. Repository Closure and Sealing Approach

    International Nuclear Information System (INIS)

    The scope of this analysis will be to develop the conceptual design of the closure seals and their locations in the Subsurface Facilities. The design will be based on the recently established program requirements for transitioning to the Site Recommendation (SR) design as outlined by ''Approach to Implementing the Site Recommendation Baseline'' (Stroupe 2000) and the ''Monitored Geologic Repository Project Description Document'' (CRWMS M andO 1999b). The objective of this analysis will be to assist in providing a description for the Subsurface Facilities System Description Document, Section 2 and finally to document any conclusions reached in order to contribute and provide support to the SR. This analysis is at a conceptual level and is considered adequate to support the SR design. The final closure barriers and seals for the ventilation shafts, and the north and south ramps will require these openings to be permanently sealed to limit excessive air and water inflows and prevent human intrusion. The major tasks identified with closure in this analysis are: (1) Developing the overall subsurface seal layout and identifying design and operational interfaces for the Subsurface Facilities. (2) Summarizing the general site conditions and general rock characteristic with respect to seal location and describing the seal selected. (3) Identify seal construction materials, methodology of construction and strategic locations including design of the seal and plugs. (4) Discussing methods to prevent human intrusion

  4. Comparison of peritoneal closure versus non-closure during caesarean section

    International Nuclear Information System (INIS)

    In modern obstetrics caesarean sections are commonly used and in all caesarean sections either peritoneal closure is done or not. This cases series was conducted to record outcomes in our setup. Methods: Cases of caesarean sections were followed for adhesions and non-adhesions in peritoneal closure and non-closure cases from 1st January to December 2011 at DHQ Hospital Haripur. In non-peritoneal closure cases adhesions were marked as compare to non-adhesions in eritoneal closure cases. Results: Sixty-five cases of peritoneal closure and 30 cases of non-peritoneal closure were followed up. There were more cases of adhesions in non-closure group (p<0.05). Conclusion: Peritoneal closure is beneficial in routine caesarean sections. (author)

  5. Flow and sediment transport across oblique channels

    DEFF Research Database (Denmark)

    Hjelmager Jensen, Jacob; Madsen, Erik Østergaard; Fredsøe, Jørgen

    1998-01-01

    A 3D numerical investigation of flow across channels aligned obliquely to the main flow direction has been conducted. The applied numerical model solves the Reynolds-averaged Navier-Stokes equations using the k-ε model for turbulence closure on a curvilinear grid. Three momentum equations are...... solved, but the computational domain is 2D due to a uniformity along the channel alignment. Two important flow features arise when the flow crosses the channel: (i) the flow will be refracted in the direction of the channel alignment. This may be described by a depth-averaged model. (ii) due to shear in...

  6. Closure spillway for the plantsite tailings dam, Quintette Operating Corporation

    Energy Technology Data Exchange (ETDEWEB)

    Sharman, K. [Quintette Operating Corporation, Tumbler Ridge, BC (Canada)

    2004-07-01

    The tailings dam at the Quintette open pit coal mine, which was open from 1983 to 2000, is 50 meters high and retains approximately 11 million cubic meters of tailings. The design of the spillway that was constructed after mine closure to allow storm management is described. The spillway includes erosion control blankets for the constructed side slopes and low flow channel floor. The area was seeded with a seed mixture of grasses, legumes, and barley, with willow cuttings on the side slopes for stability. 2 figs., 2 tabs.

  7. Neuronal dysfunction with aging and its amelioration

    OpenAIRE

    Ando, Susumu

    2012-01-01

    The author focused on the functional decline of synapses in the brain with aging to understand the underlying mechanisms and to ameliorate the deficits. The first attempt was to unravel the neuronal functions of gangliosides so that gangliosides could be used for enhancing synaptic activity. The second attempt was to elicit the neuronal plasticity in aged animals through enriched environmental stimulation and nutritional intervention. Environmental stimuli were revealed neurochemically and mo...

  8. Calcium ameliorates diarrhea in immune compromised children

    OpenAIRE

    Cheng, Sam X.; Bai, Harrison X; Gonzalez-Peralta, Regino; Mistry, Pramod K.; Gorelick, Fred S.

    2013-01-01

    Treatment of infectious diarrheas remains a challenge, particularly in immunocompromised patients in whom infections usually persist and resultant diarrhea is often severe and protracted. Children with infectious diarrhea who become dehydrated are normally treated with oral or intravenous rehydration therapy. Although rehydration therapy can replace the loss of fluid, it does not ameliorate diarrhea. Thus, over the past decades, there has been continuous effort to search for ways to safely st...

  9. Fuzzy Closure Spaces vs. Fuzzy Rough Sets

    OpenAIRE

    S. P. Tiwari; Shambhu Sharan; Yadav, Vijay K.

    2014-01-01

    This paper investigates the relationship among fuzzy rough sets, fuzzy closure spaces and fuzzy topology. It is shown that there exists a bijective correspondence between the set of all fuzzy reflexive approximation spaces and the set of all quasi-discrete fuzzy closure spaces satisfying a certain extra condition. Similar correspondence is also obtained between the set of all fuzzy tolerance approximation spaces and the set of all symmetric quasi-discrete fuzzy closure spaces satisfying a cer...

  10. Ocular Biometry in Angle Closure

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Razeghinejad

    2013-01-01

    Full Text Available Purpose: To compare ocular biometric parameters in primary angle closure suspects (PACS, primary angle closure glaucoma (PACG and acute primary angle closure (APAC. Methods: This cross-sectional study was performed on 113 patients including 33 cases of PACS, 45 patients with PACG and 35 subjects with APAC. Central corneal thickness (CCT, axial length (AL, anterior chamber depth (ACD and lens thickness (LT were measured with an ultrasonic biometer. Lens-axial length factor (LAF, relative lens position, corrected ACD (CACD and corrected lens position were calculated. The parameters were measured bilaterally but only data from the right eyes were compared. In the APAC group, biometric parameters were also compared between affected and unaffected fellow eyes. Logistic regression analysis was performed to identify risk factors. Results: No statistically significant difference was observed in biometric parameters between PACS and PACG eyes, or between affected and fellow eyes in the APAC group (P>0.05 for all comparisons. However, eyes with APAC had thicker cornea (P=0.001, thicker lens (P<0.0001, shallower ACD (P=0.009, shallower CACD (P=0.003 and larger LAF (P<0.0001. Based on ROC curve analysis, lower ACD, and larger LT, LAF and CCT values were associated with APAC. In the APAC group, LAF (P<0.0001 and CCT (P=0.001 were significant risk factors. Conclusion: This study revealed no significant difference in biometric characteristics in eyes with PACS and PACG. However, larger LAF and CCT were predictive of APAC.

  11. RFI channels

    Science.gov (United States)

    Mceliece, R. J.

    1980-01-01

    A class of channel models is presented which exhibit varying burst error severity much like channels encountered in practice. An information-theoretic analysis of these channel models is made, and conclusions are drawn that may aid in the design of coded communication systems for realistic noisy channels.

  12. From autopoiesis to semantic closure.

    Science.gov (United States)

    Stewart, J

    2000-01-01

    This article addresses the question of providing an adequate mathematical formulation for the concepts of autopoiesis and closure under efficient cause. What is required is metaphorically equivalent to reducing the act of writing to a set of mathematical equations, habitually effected by a human mathematician, within the ongoing function of the system itself. This, in turn, raises the question of the relationship between autopoiesis and semantics. The hypothesis suggested is that whereas semantics clearly requires autopoiesis, it may be also be the case that autopoiesis itself can only be materially realized in a system that is characterized by a semantic dimension. PMID:10818567

  13. 100-D Ponds closure plan. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, S.W.

    1997-09-01

    The 100-D Ponds is a Treatment, Storage, and Disposal (TSD) unit on the Hanford Facility that received both dangerous and nonregulated waste. This Closure Plan (Rev. 1) for the 100-D Ponds TSD unit consists of a RCRA Part A Dangerous Waste Permit Application (Rev. 3), a RCRA Closure Plan, and supporting information contained in the appendices to the plan. The closure plan consists of eight chapters containing facility description, process information, waste characteristics, and groundwater monitoring data. There are also chapters containing the closure strategy and performance standards. The strategy for the closure of the 100-D Ponds TSD unit is clean closure. Appendices A and B of the closure plan demonstrate that soil and groundwater beneath 100-D Ponds are below cleanup limits. All dangerous wastes or dangerous waste constituents or residues associated with the operation of the ponds have been removed, therefore, human health and the environment are protected. Discharges to the 100-D Ponds, which are located in the 100-DR-1 operable unit, were discontinued in June 1994. Contaminated sediment was removed from the ponds in August 1996. Subsequent sampling and analysis demonstrated that there is no contamination remaining in the ponds, therefore, this closure plan is a demonstration of clean closure.

  14. 100-D Ponds closure plan. Revision 1

    International Nuclear Information System (INIS)

    The 100-D Ponds is a Treatment, Storage, and Disposal (TSD) unit on the Hanford Facility that received both dangerous and nonregulated waste. This Closure Plan (Rev. 1) for the 100-D Ponds TSD unit consists of a RCRA Part A Dangerous Waste Permit Application (Rev. 3), a RCRA Closure Plan, and supporting information contained in the appendices to the plan. The closure plan consists of eight chapters containing facility description, process information, waste characteristics, and groundwater monitoring data. There are also chapters containing the closure strategy and performance standards. The strategy for the closure of the 100-D Ponds TSD unit is clean closure. Appendices A and B of the closure plan demonstrate that soil and groundwater beneath 100-D Ponds are below cleanup limits. All dangerous wastes or dangerous waste constituents or residues associated with the operation of the ponds have been removed, therefore, human health and the environment are protected. Discharges to the 100-D Ponds, which are located in the 100-DR-1 operable unit, were discontinued in June 1994. Contaminated sediment was removed from the ponds in August 1996. Subsequent sampling and analysis demonstrated that there is no contamination remaining in the ponds, therefore, this closure plan is a demonstration of clean closure

  15. Identification of Selected Child-Resistant Closures (Continuous Thread, Lug-Bayonet, and Snap Closures).

    Science.gov (United States)

    Gross, Rosalind L.; White, Harry E.

    This publication describes a selected group of child-resistant closures used in packaging five categories of medicine and household products. The material in the document was collected to train survey personnel to identify closures for a planned household study of the effectiveness of child-resistant packaging. The 39 closures described are of…

  16. 40 CFR 265.1202 - Closure and post-closure care.

    Science.gov (United States)

    2010-07-01

    ... WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Hazardous Waste Munitions and Explosives Storage § 265.1202 Closure and post-closure care. (a) At closure of a magazine or unit which stored hazardous waste under this...

  17. 40 CFR 264.1202 - Closure and post-closure care.

    Science.gov (United States)

    2010-07-01

    ... WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Hazardous Waste Munitions and Explosives Storage § 264.1202 Closure and post-closure care. (a) At closure of a magazine or unit which stored hazardous waste under this subpart, the owner or operator...

  18. Organizational closure and conceptual coherence

    Science.gov (United States)

    Scott

    2000-01-01

    This paper reviews ideas developed by the late Gordon Pask as part of this conversation theory (CT). CT uses theories of the dynamics of complex, self-organizing systems, in conjunction with models of conceptual structures, in order to give an account of conceptual coherence (for example, of a theory or a belief system) as a form of organizational closure. In Pask's own terms, CT is concerned both with the kinematics of knowledge structures and the kinetics of knowing and coming to know. The main features of modelling conceptual structures and processes used by Pask are presented. We continue by presenting a summary two-cycle model of learning, aimed to capture some of Pask's key insights with respect to conceptual coherence and the organizational closure of conceptual systems. Parallels are drawn with other work in epistemology, classic cybernetic studies of self-organization, and the concept of autopoiesis. The two-cycle model is then applied recursively to generate learning cycles and conceptual structures at different levels of abstraction, as a contribution to the work of Pask on the topology of thought. Finally, the model is applied reflexively. That is, its own form is considered as a topic for conversation and conceptualization. Carrying out such a reflection provides a coherent way of characterizing epistemological limits, while retaining a clear sense of there being an (in principle) unlimited praxeology of awareness. PMID:10818581

  19. Accelerating cleanup: Paths to closure

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, C.

    1998-06-30

    This document was previously referred to as the Draft 2006 Plan. As part of the DOE`s national strategy, the Richland Operations Office`s Paths to Closure summarizes an integrated path forward for environmental cleanup at the Hanford Site. The Hanford Site underwent a concerted effort between 1994 and 1996 to accelerate the cleanup of the Site. These efforts are reflected in the current Site Baseline. This document describes the current Site Baseline and suggests strategies for further improvements in scope, schedule and cost. The Environmental Management program decided to change the name of the draft strategy and the document describing it in response to a series of stakeholder concerns, including the practicality of achieving widespread cleanup by 2006. Also, EM was concerned that calling the document a plan could be misconstrued to be a proposal by DOE or a decision-making document. The change in name, however, does not diminish the 2006 vision. To that end, Paths to Closure retains a focus on 2006, which serves as a point in time around which objectives and goals are established.

  20. 40 CFR 265.404 - Closure.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Chemical, Physical, and Biological Treatment § 265.404 Closure. At closure, all hazardous waste and hazardous...

  1. 40 CFR 265.381 - Closure.

    Science.gov (United States)

    2010-07-01

    ... STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Thermal Treatment § 265.381 Closure. At closure, the owner or operator must remove all hazardous waste and hazardous waste residues (including, but not limited to, ash) from the thermal treatment process or equipment....

  2. 40 CFR 264.351 - Closure.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Incinerators § 264.351 Closure. At closure the owner or operator must remove all hazardous waste and hazardous...

  3. School Closures in Rural Finnish Communities

    Science.gov (United States)

    Autti, Outi; Hyry-Beihammer, Eeva Kaisa

    2014-01-01

    The network of small rural schools in Finland has been radically weakened since the global recession of the 1990s. This article focuses on the social role of rural schools and the phenomenon of school closures. Our aim is to look at rural schools from the viewpoint of local residents and examine how they experience school closures. We seek to hear…

  4. Closure of Microcosm for refurbishment

    CERN Multimedia

    2014-01-01

    Since 1994, the Microcosm exhibition has given the opportunity to visitors of all ages and backgrounds to have a first glimpse into the secrets of physics.   To ensure that Microcosm can continue fulfilling its educational aims at the same level of quality for many years to come, it is closing for renovation work on 8 December 2014 and is expected to reopen during Summer 2015. During the closure, the “Fun with Physics” workshop will not take place, but the Universe of Particles exhibition in the Globe and the Passport to the Big Bang circuit will remain accessible to the public, free of charge and with no need to book in advance.  Guided tours of CERN are also available (advance booking required via this page).

  5. Closure for milliliter scale bioreactor

    Science.gov (United States)

    Klein, David L.; Laidlaw, Robert D.; Andronaco, Gregory; Boyer, Stephen G.

    2010-12-14

    A closure for a microreactor includes a cap that is configured to be inserted into a well of the microreactor. The cap, or at least a portion of the cap, is compliant so as to form a seal with the well when the cap is inserted. The cap includes an aperture that provides an airway between the inside of the well to the external environment when the cap is inserted into the well. A porous plug is inserted in the aperture, e.g., either directly or in tube that extends through the aperture. The porous plug permits gas within the well to pass through the aperture while preventing liquids from passing through to reduce evaporation and preventing microbes from passing through to provide a sterile environment. A one-way valve may also be used to help control the environment in the well.

  6. Cacao polyphenols ameliorate autoimmune myocarditis in mice.

    Science.gov (United States)

    Zempo, Hirofumi; Suzuki, Jun-Ichi; Watanabe, Ryo; Wakayama, Kouji; Kumagai, Hidetoshi; Ikeda, Yuichi; Akazawa, Hiroshi; Komuro, Issei; Isobe, Mitsuaki

    2016-04-01

    Myocarditis is a clinically severe disease; however, no effective treatment has been established. The aim of this study was to determine whether cacao bean (Theobroma cacao) polyphenols ameliorate autoimmune myocarditis. We used an experimental autoimmune myocarditis (EAM) model in Balb/c mice. Mice with induced EAM were treated with a cacao polyphenol extract (CPE, n=12) or vehicle (n=12). On day 21, hearts were harvested and analyzed. Elevated heart weight to body weight and fibrotic area ratios as well as high cardiac cell infiltration were observed in the vehicle-treated EAM mice. However, these increases were significantly suppressed in the CPE-treated mice. Reverse transcriptase-PCR revealed that mRNA expressions of interleukin (Il)-1β, Il-6, E-selectin, vascular cell adhesion molecule-1 and collagen type 1 were lower in the CPE group compared with the vehicle group. The mRNA expressions of nicotinamide adenine dinucleotide phosphate-oxidase (Nox)2 and Nox4 were increased in the vehicle-treated EAM hearts, although CPE treatment did not significantly suppress the transcription levels. However, compared with vehicle treatment of EAM hearts, CPE treatment significantly suppressed hydrogen peroxide concentrations. Cardiac myeloperoxidase activity, the intensity of dihydroethidium staining and the phosphorylation of nuclear factor-κB p65 were also lower in the CPE group compared with the vehicle group. Our data suggest that CPE ameliorates EAM in mice. CPE is a promising dietary supplement to suppress cardiovascular inflammation and oxidative stress. PMID:26657007

  7. Acetylcholinesterase inhibition ameliorates deficits in motivational drive

    Directory of Open Access Journals (Sweden)

    Martinowich Keri

    2012-03-01

    Full Text Available Abstract Background Apathy is frequently observed in numerous neurological disorders, including Alzheimer's and Parkinson's, as well as neuropsychiatric disorders including schizophrenia. Apathy is defined as a lack of motivation characterized by diminished goal-oriented behavior and self-initiated activity. This study evaluated a chronic restraint stress (CRS protocol in modeling apathetic behavior, and determined whether administration of an anticholinesterase had utility in attenuating CRS-induced phenotypes. Methods We assessed behavior as well as regional neuronal activity patterns using FosB immunohistochemistry after exposure to CRS for 6 h/d for a minimum of 21 d. Based on our FosB findings and recent clinical trials, we administered an anticholinesterase to evaluate attenuation of CRS-induced phenotypes. Results CRS resulted in behaviors that reflect motivational loss and diminished emotional responsiveness. CRS-exposed mice showed differences in FosB accumulation, including changes in the cholinergic basal forebrain system. Facilitating cholinergic signaling ameliorated CRS-induced deficits in initiation and motivational drive and rescued immediate early gene activation in the medial septum and nucleus accumbens. Conclusions Some CRS protocols may be useful for studying deficits in motivation and apathetic behavior. Amelioration of CRS-induced behaviors with an anticholinesterase supports a role for the cholinergic system in remediation of deficits in motivational drive.

  8. The Closure of the Russian Military Base at Akhalkalaki: Challenges for the Local Energy Elite, the Informal Economy and Stability

    Directory of Open Access Journals (Sweden)

    Indra Øverland

    2009-12-01

    Full Text Available In 2007, the base of the Russian army’s 62nd Division at Akhalkalaki, Georgia was shut down. After outlining the historical role of the base in Russian–Armenian–Turkish relations, this article examines how it was the linchpin of informal economies and power relations among the Javakheti Armenians. Vital to these relations was the control of the disproportionately large number of petrol stations in Akhalkalaki by key economic groups. The article then offers several reasons why, in light of the informal socio-economic structures and interests of local power brokers, one might have expected the closure of the base to result in upheaval among the Javakheti Armenians. Finally, the paper briefly considers Georgian and Western efforts to ameliorate the socio-economic situation, before concluding with reasons for the absence of major unrest following closure of the Akhalkalaki base.

  9. Use of Coffee Pulp and Minerals for Natural Soil Ameliorant

    Directory of Open Access Journals (Sweden)

    Pujiyanto Pujiyanto

    2007-05-01

    Full Text Available In coffee plantation, solid waste of coffee pulp is usually collected as heap nearby processing facilities for several months prior being used as compost. The practice is leading to the formation of odor and liquid which contaminate the environment. Experiments to evaluate the effect of natural soil ameliorant derived from coffee pulp and minerals were conducted at The Indonesian Coffee and Cocoa Research Institute in Jember, East Java. The experiments were intended to optimize the use of coffee pulp to support farming sustainability and minimize negative impacts of solid waste disposal originated from coffee cherry processing. Prior to applications, coffee pulp was hulled to organic paste. The paste was then mixed with 10% minerals (b/b. Composition of the minerals was 50% zeolite and 50% rock phosphate powder. The ameliorant was characterized for their physical and chemical properties. Agronomic tests were conducted on coffee and cocoa seedling. The experiments were arranged according to Randomized Completely Design with 2 factors, consisted of natural ameliorant and inorganic fertilizer respectively. Natural ameliorant derived from coffee pulp was applied at 6 levels: 0, 30, 60, 90, 120 and 150 g dry ameliorant/seedling of 3 kg soil, equivalent to 0, 1, 2, 3, 4 and 5% (b/b of ameliorant respectively. Inorganic fertilizer was applied at 2 levels: 0 and 2 g fertilizer/application of N-P-K compound fertilizer of 15-15-15 respectively. The inorganic fertilizer was applied 4 times during nursery of coffee and cocoa. The result of the experiment indicated that coffee pulp may be used as natural soil ameliorant. Composition of ameliorant of 90% coffee pulp and 10% of minerals has good physical and chemical characteristics for soil amelioration. The composition has high water holding capacity; cations exchange capacity, organic carbon and phosphorus contents which are favorable to increase soil capacity to support plant growth. Application of

  10. Closure proposal: 183-H Solar Evaporation Basins

    International Nuclear Information System (INIS)

    This document describes the overall approach and logic for implementing clean closure of the 183-H Solar Evaporation basins (183-H) in a cost-effective and timely manner and in accordance with all applicable regulations. The Resource Conservation and Recovery Act of 1976 and the Washington Administrative Code (WAC) 173-303 are the regulatory bases for this closure strategy. The closure described herein is consistent with potential future land uses, and with remedial action planning in the 100-H area, as well as with other decontamination and decommissioning (D ampersand D) of the 100-H structures

  11. Social and macro economic impact of closure

    International Nuclear Information System (INIS)

    The social consequences of closure of Ignalina NPP will largely depend on the actions the Government takes. If it puts in place the conditions which enable the International Financial Institutions to assist Lithuania, both in providing loans and grants for decommissioning and (in the case of the EU) providing Structural Adjustment Funds for the regional economic development of the Visaginas area, then solutions to the problems of closure can be found. But if the Government delays putting into place the necessary conditions, then Lithuania will be left to solve the problems of - inter alia necessary - closure of Ignalina NPP on its own. (author)

  12. An Abscisic Acid-Independent Oxylipin Pathway Controls Stomatal Closure and Immune Defense in Arabidopsis

    Science.gov (United States)

    Mondy, Samuel; Tranchimand, Sylvain; Rumeau, Dominique; Boudsocq, Marie; Garcia, Ana Victoria; Douki, Thierry; Bigeard, Jean; Laurière, Christiane; Chevalier, Anne; Castresana, Carmen; Hirt, Heribert

    2013-01-01

    Plant stomata function in innate immunity against bacterial invasion and abscisic acid (ABA) has been suggested to regulate this process. Using genetic, biochemical, and pharmacological approaches, we demonstrate that (i) the Arabidopsis thaliana nine-specific-lipoxygenase encoding gene, LOX1, which is expressed in guard cells, is required to trigger stomatal closure in response to both bacteria and the pathogen-associated molecular pattern flagellin peptide flg22; (ii) LOX1 participates in stomatal defense; (iii) polyunsaturated fatty acids, the LOX substrates, trigger stomatal closure; (iv) the LOX products, fatty acid hydroperoxides, or reactive electrophile oxylipins induce stomatal closure; and (v) the flg22-mediated stomatal closure is conveyed by both LOX1 and the mitogen-activated protein kinases MPK3 and MPK6 and involves salicylic acid whereas the ABA-induced process depends on the protein kinases OST1, MPK9, or MPK12. Finally, we show that the oxylipin and the ABA pathways converge at the level of the anion channel SLAC1 to regulate stomatal closure. Collectively, our results demonstrate that early biotic signaling in guard cells is an ABA-independent process revealing a novel function of LOX1-dependent stomatal pathway in plant immunity. PMID:23526882

  13. 2101-M pond closure plan

    International Nuclear Information System (INIS)

    This document describes activities for the closure of a surface impoundment (2101-M Pond) at the Hanford Site. The 2101-H Pond was initially constructed in 1953 to serve as a drainage collection area for the 2101-H Building. (Until the Basalt Waste Isolation Project (BWIP) Laboratory was constructed in the 2101-M Building in 1979--1981, the only source contributing discharge to the pond was condensate water from the 2101-H Building heating, ventilation, and air conditioning (HVAC) system. The drains for the BWIP Laboratory rooms were plumbed into a 4-in., cast-iron, low-pressure drain pipe that carries waste water from the HVAC system to the pond. During the active life of the BWIP Laboratory, solutions of dissolved barium in groundwater samples were discharged to the 2101-M Pond via the laboratory drains. As a result of the discharges, a Part A permit application was initially submitted to the Washington State Department of Ecology (Ecology) in August 1986 which designates the 2101-M Pond as a surface impoundment

  14. The N=16 subshell closure

    International Nuclear Information System (INIS)

    The sequence of magic numbers for stable nuclei is now well understood. However the magnitude of shell gap may evolve from stability to drip line. Several observables show that N = 16 neutron-rich isotones present a higher stability compared to their neighbors on the N-Z chart. The spectroscopy of the levels of Ne27, involving sd and fp shells, has allowed us to study the evolution of the nuclear shells responsible for the structure changes in N 16 isotones. In this framework we have studied the neutron transfer reaction Ne26(d,p)Ne27 by inverted kinematics at 9,7 MeV/u. A cryogenic D2 target (17 mg.cm-2) has been used. The use of the magnetic spectrometer Vamos and that of the Exogam photon detector in coincidence operating mode has allowed us to achieve the spectroscopy of Ne27. The results show a reduction in the gap between sd and fp shells for N = 17 isotones as we go from stability toward the neutron drip line. We have also performed a theoretical study in mean-field theory and beyond it through configuration mixing so that we can see the evolution of the isospin of the N = 16 subshell's closure. We have used a HFB (Hartree-Fock-Bogoliubov) with the finite range D1S effective interaction. (A.C.)

  15. Cyanoacrylate for Intraoral Wound Closure: A Possibility?

    Directory of Open Access Journals (Sweden)

    Parimala Sagar

    2015-01-01

    Full Text Available Wound closure is a part of any surgical procedure and the objective of laceration repair or incision closure is to approximate the edges of a wound so that natural healing process may occur. Over the years new biomaterials have been discovered as an alternate to conventional suture materials. Cyanoacrylate bioadhesives are one among them. They carry the advantages of rapid application, patient comfort, resistance to infection, hemostatic properties, and no suture removal anxiety. Hence this study was undertaken to study the effect of long chain cyanoacrylate as an adhesive for intraoral wound closure and also to explore its hemostatic and antibacterial effects. Isoamyl-2-cyanoacrylate (AMCRYLATE was used as the adhesive in the study. In conclusion isoamyl cyanoacrylate can be used for intraoral wound closure, as an alternative to sutures for gluing the mucoperiosteum to bone, for example, after impaction removal, periapical surgeries, and cleft repair. Its hemostatic and antibacterial activity has to be further evaluated.

  16. 50 CFR 679.22 - Closures.

    Science.gov (United States)

    2010-10-01

    ..., see the List of CFR Sections Affected, which appears in the Finding Aids section of the printed volume... § 679.20(i). (d) Groundfish as prohibited species closures. See § 679.20(d). (e) Overfishing...

  17. Percutaneous closure of the patent foramen ovale.

    Science.gov (United States)

    Surmely, J-F; Meier, B

    2007-10-01

    A patent foramen ovale (PFO) is a common finding present in 25% of the population. A relationship between PFO and several clinical conditions such as stroke, migraine, platypnea-orthodeoxia syndrome, neurological decompression illness in divers, high altitude pulmonary edema, sleep apnea, and economy class syndrome have been documented. Observational non-randomized studies have shown percutaneous PFO closure more effective than medical treatment for stroke prevention, in particular in patients with complete closure as well as in patients with more than one cerebrovascular event at baseline. In the case of migraine, PFO closure has been shown to result in a marked reduction in migraine burden or migraine days. PFO anatomy, epidemiological data on associated clinical conditions, comparison between percutaneous closure and medical treatment, as well as the technical aspect of the procedure are described in this review. PMID:17912171

  18. Underground disposal facility closure design 2012

    International Nuclear Information System (INIS)

    Posiva has developed a detailed design for construction of a KSB-3 type disposal facility for spent nuclear fuel on Olkiluoto Island. The disposal facility design calls for construction of five shafts and an access tunnel that will serve to connect the disposal level to the surface. Routes to the underground disposal facility would be via the underground rock characterisation facility, ONKALO, which is currently under construction. The positioning of the underground disposal facility at Olkiluoto Island has been done by taking into account the main geological structures and available geological information on the site. Conditions actually encountered on reaching the potential disposal level will be assessed and the final layout selected at that time. The closure of the underground facility shall complete the isolation of the spent nuclear fuel and contribute to restoring and maintaining the favourable natural conditions in the bedrock. Beyond the deposition tunnels there remain underground openings associated with central and access tunnels, shafts and technical rooms or other spaces that comprise by definition the closure of the underground disposal facility. The underground disposal facility's general closure design described in this document deals specifically with the backfill and plugs installed in regions beyond the deposition tunnels and how the local geosphere may affect their performance. These tunnels, rooms and shafts represent approximately 60 % of the volume of the underground disposal facility openings and will intersect a variety of geological and hydrogeological features. Hence, backfilling and plugging of the disposal facility excavations in these regions will need to be approached in a flexible manner with the ability to modify the materials used to reflect the properties of the features intersected. Based on relevant available information the basis for flexible and general closure plan has been developed. The general closure plan takes into

  19. Cyanoacrylate for Intraoral Wound Closure: A Possibility?

    OpenAIRE

    Parimala Sagar; Kavitha Prasad; Lalitha, R. M.; Krishnappa Ranganath

    2015-01-01

    Wound closure is a part of any surgical procedure and the objective of laceration repair or incision closure is to approximate the edges of a wound so that natural healing process may occur. Over the years new biomaterials have been discovered as an alternate to conventional suture materials. Cyanoacrylate bioadhesives are one among them. They carry the advantages of rapid application, patient comfort, resistance to infection, hemostatic properties, and no suture removal anxiety. Hence this s...

  20. Special closures for steel drum shipping containers

    International Nuclear Information System (INIS)

    The objective of this program was to develop special lid closures for typical, steel drum, radioactive material shipping containers. Previous experience and testing had shown that the existing container was adequate to withstand the required environmental tests for certification, but that the lid and closure were just marginally effective. Specifically, the lid closure failed to consistently maintain a tight seal between the container and the lid after drop tests, thus causing the package contents to be vulnerable in the subsequent fire test. Recognizing the deficiency, the United States Energy Research and Development Administration requested the development of new closure(s) which would: (1) be as strong and resistant to a drop as the bottom of the container; (2) have minimal economic impact on the overall container cost; (3) maximize the use of existing container designs; (4) consider crush loads; and (5) result in less dependence on personnel and loading procedures. Several techniques were evaluated and found to be more effective than the standard closure mechanism. Of these, three new closure techniques were designed, fabricated, and proven to be structurally adequate to provide containment when a 454-kg drum was drop tested from 9.14-m onto an unyielding surface. The three designs were: (1) a 152-mm long lid extension or skirt welded to the standard drum lid, (2) a separate inner lid, with 152-mm long skirt and (3) C-clamps used at the container-lid interface. Based upon structural integrity, economic impact, and minimal design change, the lid extension is the recommended special closure

  1. Exceptional closure of UNIQA office at CERN

    CERN Multimedia

    HR Department

    2009-01-01

    The UNIQA office at CERN will be closed from Wednesday 18 February to Friday 20 February due to painting work. During this closure, the Headquarters of UNIQA in Geneva will remain at the disposal of the members. See details https://cern.ch/chis/UNIQA_Offices.asp The CERN office will re-open on Monday 23 February according to the normal schedule. We apologise for any inconvenience caused by this closure.

  2. Statistical properties of flux closure induced by solar wind dynamic pressure fronts

    OpenAIRE

    Hubert, Benoît; Blockx, Caroline; Milan, S. E.; Cowley, S. W. H

    2009-01-01

    We present a statistical study of flux closure intervals induced by solar wind dynamic pressure fronts. We consider that a dynamic pressure front reaches the Earth when a dayside subauroral proton flash is observed in the SI2 channel of the IMAGE-FUV experiment. This pragmatic criterion selects both weak and strong pressure fronts. It is found that the preconditioning of the magnetosphere prior to the pressure pulse arrival mainly governs the magnetospheric response to a weak solar wind dynam...

  3. 105-DR Large Sodium Fire Facility closure activities evaluation report

    International Nuclear Information System (INIS)

    This report evaluates the closure activities at the 105-DR Large Sodium Fire Facility. The closure activities discussed include: the closure activities for the structures, equipment, soil, and gravel scrubber; decontamination methods; materials made available for recycling or reuse; and waste management. The evaluation compares these activities to the regulatory requirements and closure plan requirements. The report concludes that the areas identified in the closure plan can be clean closed

  4. Worsening angle closure glaucoma and choroidal detachments subsequent to closure of a carotid cavernous fistula

    Directory of Open Access Journals (Sweden)

    Thinda Sumeer

    2012-07-01

    Full Text Available Abstract Background Carotid cavernous fistulas are abnormal communications between the cavernous sinus and the external or internal carotid arteries. Although rare, closure of carotid cavernous fistulas can lead to immediate ocular complications. To our knowledge, our case represents the first report of worsening angle closure glaucoma and choroidal detachments over an extended period of two months subsequent to closure of a carotid cavernous fistula. Case presentation A 70-year-old female with a history of primary angle closure glaucoma presented with 4 mm of proptosis, resistance to retropulsion, tortuous corkscrew blood vessels and an orbital bruit of the right eye. Diagnostic cerebral angiogram showed a small indirect Barrow type D right carotid cavernous fistula. Transarterial embolization was planned but repeat cerebral angiography prior to the procedure demonstrated spontaneous partial closure of the carotid cavernous fistula and the procedure was aborted. One month later, our patient was noted to have worsening vision and choroidal detachments of the right eye. She declined further testing and was thus started on self-administered manual carotid jugular compressions. One month later, she developed progressive worsening of her choroidal detachments and angle closure. She eventually opted for surgical intervention but repeat cerebral angiography showed significant thrombosis of the carotid cavernous fistula and no intervention was warranted. Examination two months later showed complete resolution of the choroidal detachments and open angles of both eyes. Conclusions Our patient demonstrated worsening angle closure glaucoma and choroidal detachments after spontaneous closure of her carotid cavernous fistula had been noted. Ocular complications, including acute angle closure, have been reported to occur immediately after closure of carotid cavernous fistulas, but not over months as in our patient. It is imperative that individuals who have

  5. Accelerating cleanup: Paths to closure

    International Nuclear Information System (INIS)

    This report describes the status of Environmental Management's (EM's) cleanup program and a direction forward to complete achievement of the 2006 vision. Achieving the 2006 vision results in significant benefits related to accomplishing EM program objectives. As DOE sites accelerate cleanup activities, risks to public health, the environment, and worker safety and health are all reduced. Finding more efficient ways to conduct work can result in making compliance with applicable environmental requirements easier to achieve. Finally, as cleanup activities at sites are completed, the EM program can focus attention and resources on the small number of sites with more complex cleanup challenges. Chapter 1 describes the process by which this report has been developed and what it hopes to accomplish, its relationship to the EM decision-making process, and a general background of the EM mission and program. Chapter 2 describes how the site-by-site projections were constructed, and summarizes, for each of DOE's 11 Operations/Field Offices, the projected costs and schedules for completing the cleanup mission. Chapter 3 presents summaries of the detailed cleanup projections from three of the 11 Operations/Field Offices: Rocky Flats (Colorado), Richland (Washington), and Savannah River (South Carolina). The remaining eight Operations/Field Office summaries are in Appendix E. Chapter 4 reviews the cost drivers, budgetary constraints, and performance enhancements underlying the detailed analysis of the 353 projects that comprise EM's accelerated cleanup and closure effort. Chapter 5 describes a management system to support the EM program. Chapter 6 provides responses to the general comments received on the February draft of this document

  6. NPAR- products, applications and closure

    Energy Technology Data Exchange (ETDEWEB)

    Vora, J.P.

    1995-04-01

    Almost a decade ago the Office of Nuclear Regulatory Research (RES) developed and implemented a comprehensive research program (NUREG-1144) widely known as NPAR or Nuclear Plant Aging Research. The NPAR program is a structured research program specifically oriented to understanding significant age-related degradation mechanisms and their long term effects on properties and performance of important components and systems and ways to mitigate detrimental effects of aging. It provided a road map and a phased approach to research that is applicable to any structure, system, or component of interest. This hardware-oriented engineering research program led the industry worldwide and communicated a need to understand and manage age-related degradation effects in selected but important structures and components. At the conclusion (1995) of the NPAR program, 22 electrical and mechanical components, 13 safety-related systems, and 10 special topics will have been studied and results summarized in 160 technical reports. This reference library of information listed and summarized in NUREG-1377, Rev. No. 4 provides a foundation upon which individual programs can be built for the specific needs of a utility, a regulator, or equipment manufacturers. During the life of the NPAR program, it has provided technical bases and support for license renewal, codes and standards, resolution of generic safety issues, information notices, regulatory guides and the standard Review Plan, as well as the Office of Nuclear Reactor Regulation and The NRC Regions. All ongoing NPAR activities will either be completed or terminated by the end of 1995. No new initiative will be undertaken. This paper summarizes NPAR products and accomplishments, application of the research results, and its status and closure.

  7. NPAR- products, applications and closure

    International Nuclear Information System (INIS)

    Almost a decade ago the Office of Nuclear Regulatory Research (RES) developed and implemented a comprehensive research program (NUREG-1144) widely known as NPAR or Nuclear Plant Aging Research. The NPAR program is a structured research program specifically oriented to understanding significant age-related degradation mechanisms and their long term effects on properties and performance of important components and systems and ways to mitigate detrimental effects of aging. It provided a road map and a phased approach to research that is applicable to any structure, system, or component of interest. This hardware-oriented engineering research program led the industry worldwide and communicated a need to understand and manage age-related degradation effects in selected but important structures and components. At the conclusion (1995) of the NPAR program, 22 electrical and mechanical components, 13 safety-related systems, and 10 special topics will have been studied and results summarized in 160 technical reports. This reference library of information listed and summarized in NUREG-1377, Rev. No. 4 provides a foundation upon which individual programs can be built for the specific needs of a utility, a regulator, or equipment manufacturers. During the life of the NPAR program, it has provided technical bases and support for license renewal, codes and standards, resolution of generic safety issues, information notices, regulatory guides and the standard Review Plan, as well as the Office of Nuclear Reactor Regulation and The NRC Regions. All ongoing NPAR activities will either be completed or terminated by the end of 1995. No new initiative will be undertaken. This paper summarizes NPAR products and accomplishments, application of the research results, and its status and closure

  8. Accelerating cleanup: Paths to closure

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    This report describes the status of Environmental Management`s (EM`s) cleanup program and a direction forward to complete achievement of the 2006 vision. Achieving the 2006 vision results in significant benefits related to accomplishing EM program objectives. As DOE sites accelerate cleanup activities, risks to public health, the environment, and worker safety and health are all reduced. Finding more efficient ways to conduct work can result in making compliance with applicable environmental requirements easier to achieve. Finally, as cleanup activities at sites are completed, the EM program can focus attention and resources on the small number of sites with more complex cleanup challenges. Chapter 1 describes the process by which this report has been developed and what it hopes to accomplish, its relationship to the EM decision-making process, and a general background of the EM mission and program. Chapter 2 describes how the site-by-site projections were constructed, and summarizes, for each of DOE`s 11 Operations/Field Offices, the projected costs and schedules for completing the cleanup mission. Chapter 3 presents summaries of the detailed cleanup projections from three of the 11 Operations/Field Offices: Rocky Flats (Colorado), Richland (Washington), and Savannah River (South Carolina). The remaining eight Operations/Field Office summaries are in Appendix E. Chapter 4 reviews the cost drivers, budgetary constraints, and performance enhancements underlying the detailed analysis of the 353 projects that comprise EM`s accelerated cleanup and closure effort. Chapter 5 describes a management system to support the EM program. Chapter 6 provides responses to the general comments received on the February draft of this document.

  9. The Fernald Closure Project: Lessons Learned

    International Nuclear Information System (INIS)

    For nearly 37 years, the U.S. Department of Energy site at Fernald - near Cincinnati, Ohio - produced 230,000 metric tons (250,000 short tons) of high-purity, low-enriched uranium for the U.S. Defense Program, generating more than 5.4 million metric tons (6 million short tons) of liquid and solid waste as it carried out its Cold War mission. The facility was shut down in 1989 and clean up began in 1992, when Fluor won the contract to clean up the site. Cleaning up Fernald and returning it to the people of Ohio was a $4.4 billion mega environmental-remediation project that was completed in October 2006. Project evolved through four phases: - Conducting remedial-investigation studies to determine the extent of damage to the environment and groundwater at, and adjacent to, the production facilities; - Selecting cleanup criteria - final end states that had to be met that protect human health and the environment; - Selecting and implementing the remedial actions to meet the cleanup goals; - Executing the work in a safe, compliant and cost-effective manner. In the early stages of the project, there were strained relationships - in fact total distrust - between the local community and the DOE as a result of aquifer contamination and potential health effects to the workers and local residents. To engage citizens and interested stakeholders groups in the decision-making process, the DOE and Fluor developed a public-participation strategy to open the channels of communication with the various parties: site leadership, technical staff and regulators. This approach proved invaluable to the success of the project, which has become a model for future environmental remediation projects. This paper will summarize the history and shares lessons learned: the completion of the uranium-production mission to the implementation of the Records of Decision defining the cleanup standards and the remedies achieved. Lessons learned fall into ten categories: - Regulatory approach with end

  10. Special closures for steel drum shipping containers

    International Nuclear Information System (INIS)

    The objective of this program was to develop special lid closures for standard, steel drum, radioactive material shipping containers. Previous experience and testing had shown that the existing container was adequate to withstand the required environmental tests for certification, but that the lid and closure was just marginally effective. Specifically, the lid closure failed to consistently maintain a tight seal between the container and the lid after drop tests, thus causing the package contents to be vulnerable in the subsequent fire test. Recognizing the deficiency, the United States Energy Research and Development Administration requested the development of new closures which would: (1) be as strong and resistant to a drop as the bottom of the container; (2) have minimal economic impact on the overall container cost; (3) maximize the use of existing container designs; (4) consider crush loads; and (5) result in less dependence on personnel and loading procedures. Several techniques were evaluated and found to be more effective than the standard closure mechanism. Of these, three new closure techniques were designed, fabricated, and proven to be structurally adequate to provide containment when a 454-kg drum was drop tested from 9.14m onto an unyielding surface. The three designs were: (1) a 152-mm long lid extension or skirt welded to the standard drum lid, (2) a separate inner lid, with 152-mm long skirt, and (3) C-clamps used at the container-lid interface. Based upon structural integrity, economic impact, and minimal design change, the lid extension is the recommended special closure. (author)

  11. An eddy closure for potential vorticity

    Energy Technology Data Exchange (ETDEWEB)

    Ringler, Todd D [Los Alamos National Laboratory

    2009-01-01

    The Gent-McWilliams (GM) parameterization is extended to include a direct influence in the momentum equation. The extension is carried out in two stages; an analysis of the inviscid system is followed by an analysis of the viscous system. In the inviscid analysis the momentum equation is modified such that potential vorticity is conserved along particle trajectories following a transport velocity that includes the Bolus velocity in a manner exactly analogous to the continuity and tracer equations. In addition (and in contrast to traditional GM closures), the new formulation of the inviscid momentum equation results in a conservative exchange between potential and kinetic forms of energy. The inviscid form of the eddy closure conserves total energy to within an error proportional to the time derivative of the Bolus velocity. The hypothesis that the viscous term in the momentum equation should give rise to potential vorticity being diffused along isopycnals in a manner analogous to other tracers is examined in detail. While the form of the momentum closure that follows from a strict adherence to this hypothesis is not immediately interpretable within the constructs of traditional momentum closures, three approximations to this hypothesis results in a form of dissipation that is consistent with traditional Laplacian diffusion. The first two approximations are that relative vorticity, not potential vorticity, is diffused along isopyncals and that the flow is in approximate geostrophic balance. An additional approximation to the Jacobian term is required when the dissipation coefficient varies in space. More importantly, the critique of this hypothesis results in the conclusion that the viscosity parameter in the momentum equation should be identical to the tradition GM closure parameter {Kappa}. Overall, we deem the viscous form of the eddy closure for potential vorticity as a viable closure for use in ocean circulation models.

  12. Morphological dynamics of an englacial channel

    Directory of Open Access Journals (Sweden)

    G. Vatne

    2015-08-01

    Full Text Available Despite an interest in the hydraulic functioning of supraglacial and englacial channels over the last four decades, the processes and forms of such ice-bounded streams have remained poorly documented. Recent glaciological research has demonstrated the potential significance of so-called "cut and closure" streams, where englacial or subglacial flowpaths are created from the long-term incision of supraglacial channels. These flowpaths are reported to exhibit step-pool morphology, comprising knickpoints and/or knickzones, albeit exaggerated in dimensions in comparison to their supraglacial channel counterparts. However, little is known of the development of such channels' morphology. Here, we examine the spatial organization of step-pools and the upstream migration of steps, many of which form knickzones, with repeated surveys over a 10 year period in an englacial conduit in cold-based Austre Brøggerbreen, Svalbard. The observations show upstream knickpoint recession to be the dominant process for channel evolution. This is paralleled by an increase in average step height and conduit gradient over time. Characteristic channel reach types and step-riser forms are consistently observed in each of the morphological surveys reported. We suggest that the formation of steps has a hydrodynamic origin, where step-pool geometry is more efficient for energy dissipation than meanders, and that the englacial channel system is one in rapid transition rather than in dynamic equilibrium. The evolution and recession of knickzones reported here result in the formation of a 37 m moulin, suggesting over time the englacial channel may evolve towards a stable end-point characterised by a singular vertical descent to the local hydraulic base level. In light of this, our observations highlight the need to further examine the adjustment processes in cut-and-closure channels to better understand their coupling to supraglacial meltwater sources and role and potential

  13. Closure of shallow underground injection wells

    International Nuclear Information System (INIS)

    Shallow injection wells have long been used for disposing liquid wastes. Some of these wells have received hazardous or radioactive wastes. According to US Environmental Protection Agency (EPA) regulations, Class IV wells are those injection wells through which hazardous or radioactive wastes are injected into or above an underground source of drinking water (USDW). These wells must be closed. Generally Class V wells are injection wells through which fluids that do not contain hazardous or radioactive wastes are injected into or above a USDW. Class V wells that are responsible for violations of drinking water regulations or that pose a threat to human health must also be closed. Although EPA regulations require closure of certain types of shallow injection wells, they do not provide specific details on the closure process. This paper describes the regulatory background, DOE requirements, and the steps in a shallow injection well closure process: Identification of wells needing closure; monitoring and disposal of accumulated substances; filling and sealing of wells; and remediation. In addition, the paper describes a major national EPA shallow injection well enforcement initiative, including closure plan guidance for wells used to dispose of wastes from service station operations

  14. Strategic Planning for Hot Cell Closure

    International Nuclear Information System (INIS)

    The United States Department of Energy (DOE) and its contractor were remediating a large hot cell complex to mitigate the radiological hazard. A Resource Conservation and Recovery Act (RCRA) closure unit was determined to be located within the complex. The regulator established a challenge to develop an acceptable closure plan on a short schedule (four months). The scope of the plan was to remove all excess equipment and mixed waste from the closure unit, establish the requirements of the legally binding Closure Plan and develop an acceptable schedule. The complex has several highly radioactive tanks, tank vaults, piping, and large hot cells containing complex chemical processing equipment. Driven by a strong need to develop an effective strategy to meet cleanup commitments, three principles were followed to develop an acceptable plan: (1) Use a team approach, (2) Establish a buffer zone to support closure, and (3) Use good practice when planning the work sequence. The team was composed of DOE, contractor, and Washington State Department of Ecology (Regulator) staff. The team approach utilized member expertise and fostered member involvement and communication. The buffer zone established an area between the unregulated parts of the building and the areas that were allegedly not in compliance with environmental standards. Introduction of the buffer zone provided simplicity, clarity, and flexibility into the process. Using good practice means using the DOE Integrated Safety Management Core Functions for planning and implementing work safely. Paying adequate attention to detail when the situation required contributed to the process credibility and a successful plan

  15. PHASE CLOSURE NULLING: THEORY AND PRACTICE

    Directory of Open Access Journals (Sweden)

    A. Chelli

    2009-01-01

    Full Text Available We provide a complete theory of the phase closure of a binary system in which a small, feeble, and unresolved companion acts as a perturbing parameter on the spatial frequency spectrum of a dominant, bright, resolved source. We demonstrate that the in uence of the companion can be measured with precision by measuring the phase closure of the system near the nulls of the primary visibility function. In these regions of phase closure nulling, frequency intervals always exist where the phase closure signature of the companion is larger than any systematic error and can thus be measured. We show that this technique allows retrieval of many astrophysically relevant properties of faint and close companions such as ux, position, and in favorable cases, spectrum. As a proof of concept, using the AMBER/VLTI instrument with 3 auxiliary telescopes of 1.8 m and only 15 minutes of on-sky integration, we detected the ve magnitudes fainter companion of HD 59717 at only 3.5 stellar radii distance from the primary. This is one of the highest contrast detected by interferometry between a companion and its parent star. We conclude by a rapid study of the potentialities of phase closure nulling observations with current interferometers and explore the requirements for a new type of dedicated instrument.

  16. Primary angle-closure glaucoma: an update.

    Science.gov (United States)

    Wright, Carrie; Tawfik, Mohammed A; Waisbourd, Michael; Katz, Leslie J

    2016-05-01

    Primary angle-closure glaucoma is potentially a devastating disease, responsible for half of glaucoma-related blindness worldwide. Angle closure is characterized by appositional approximation or contact between the iris and trabecular meshwork. It tends to develop in eyes with shallow anterior chambers, anteriorly positioned or pushed lenses, and angle crowding. Risk of primary angle-closure glaucoma is high among women, the elderly and the hyperopic, and it is most prevalent in Asia. Investigation into genetic mechanisms of glaucoma inheritance is underway. Diagnosis relies on gonioscopy and may be aided by anterior segment optical coherence tomography and ultrasound biomicroscopy. Treatment is designed to control intraocular pressure while monitoring changes to the angle and optic nerve head. Treatment typically begins with medical management through pressure-reducing topical medications. Peripheral iridotomy is often performed to alleviate pupillary block, while laser iridoplasty has been found effective for mechanisms of closure other than pupillary block, such as plateau iris syndrome. Phacoemulsification, with or without goniosynechialysis, both in eyes with existing cataracts and in those with clear lenses, is thus far a viable treatment alternative. Long-term research currently underway will examine its efficacy in cases of angle closure in early stages of the disease. Endoscopic cyclophotocoagulation is another treatment option, which can be combined with cataract surgery. Trabeculectomy remains effective therapy for more advanced cases. PMID:26119516

  17. Columbus Closure Project Released without Radiological Restrictions

    International Nuclear Information System (INIS)

    The Columbus Closure Project (CCP), a historic radiological research complex, was cleaned up for future use without radiological restriction in 2006. The CCP research and development site contributed to national defense, nuclear fuel fabrication, and the development of safe nuclear reactors in the United States until 1988 when research activities were concluded for site decommissioning. In November of 2003, the Ohio Field Office of the U.S. Department of Energy contracted ECC/E2 Closure Services, LLC (Closure Services) to complete the removal of radioactive contamination from of a 1955 era nuclear sciences area consisting of a large hot cell facility, research reactor building and underground piping. The project known as the Columbus Closure Project (CCP) was completed in 27 months and brought to a close 16 years of D and D in Columbus, Ohio. This paper examines the project innovations and challenges presented during the Columbus Closure Project. The examination of the CCP includes the project regulatory environment, the CS safety program, accelerated clean up innovation, project execution strategies and management of project waste issues and the regulatory approach to site release 'without radiological restrictions'. (authors)

  18. Amelioration of safety management in infrastructure projects

    Directory of Open Access Journals (Sweden)

    Mr. Gopinath S.Mohite

    2014-11-01

    Full Text Available Accidents are a major public health concern, resulting in an estimated 1.2 million deaths and 50 million injuries worldwide each year specifically, the relationships between drivers' characteristics and road accidents are not fully understood. Many factors are involved in the accident occurrence at construction site. Some important elements that create a significant portion of accidents include: safety management error, poor training programs, human element, act of god, outdated procedure and no clear monitoring policy. Although some of these items are inevitable, but the occurrence of the largest part can be prevented. Therefore, for ameliorating the safety in a project each of these items should be analyzed and a practical approach introduced. In general, near miss, incident and accident are three dependent levels that mainly lead to injury. Risk and hazard are allocated in first level which means near miss, therefore, no on-time identification of hazard and risk causes to create incident and preventing accident in incident stage is unavoidable.

  19. Riboflavin ameliorates cisplatin induced toxicities under photoillumination.

    Directory of Open Access Journals (Sweden)

    Iftekhar Hassan

    Full Text Available BACKGROUND: Cisplatin is an effective anticancer drug that elicits many side effects mainly due to induction of oxidative and nitrosative stresses during prolonged chemotherapy. The severity of these side effects consequently restricts its clinical use under long term treatment. Riboflavin is an essential vitamin used in various metabolic redox reactions in the form of flavin adenine dinucleotide and flavin mononucleotide. Besides, it has excellent photosensitizing property that can be used to ameliorate these toxicities in mice under photodynamic therapy. METHODS AND FINDINGS: Riboflavin, cisplatin and their combinations were given to the separate groups of mice under photoilluminated condition under specific treatment regime. Their kidney and liver were excised for comet assay and histopathological studies. Furthermore, Fourier Transform Infrared Spectroscopy of riboflavin-cisplatin combination in vitro was also conducted to investigate any possible interaction between the two compounds. Their comet assay and histopathological examination revealed that riboflavin in combination with cisplatin was able to protect the tissues from cisplatin induced toxicities and damages. Moreover, Fourier Transform Infrared Spectroscopy analysis of the combination indicated a strong molecular interaction among their constituent groups that may be assigned for the protective effect of the combination in the treated animals. CONCLUSION: Inclusion of riboflavin diminishes cisplatin induced toxicities which may possibly make the cisplatin-riboflavin combination, an effective treatment strategy under chemoradiotherapy in pronouncing its antineoplastic activity and sensitivity towards the cancer cells as compared to cisplatin alone.

  20. Hanford Patrol Academy demolition sites closure plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    The Hanford Site is owned by the U.S. Government and operated by the U.S. Department of Energy, Richland Operations Office. Westinghouse Hanford Company is a major contractor to the U.S. Department of Energy, Richland Operations Office and serves as co-operator of the Hanford Patrol Academy Demolition Sites, the unit addressed in this paper. This document consists of a Hanford Facility Dangerous Waste Part A Permit Application, Form 3 (Revision 4), and a closure plan for the site. An explanation of the Part A Form 3 submitted with this closure plan is provided at the beginning of the Part A section. This Hanford Patrol Academy Demolition Sites Closure Plan submittal contains information current as of December 15, 1994.

  1. Pressurizer manway closure re-engineering

    International Nuclear Information System (INIS)

    The primary heat transport system pressurizer vessels at Darlington NGS have required substantial maintenance of the gasketed joints. Two of these joints are the upper inspection port and the lower manway. In at least one instance there has been erosion damage to the carbon steel sealing faces from leakage of the high energy primary fluid. In the work described in the paper, each of the two closures was re-engineered to incorporate a seal welded diaphragm in place of the gasket. This approach for which patent protection is sought, required machining and weld build up of the nozzle gasket area to facilitate seal welding of a custom diaphragm plate. The closure covers were modified to support the diaphragm and were reinstalled using the original bolting arrangement. The paper describes the re-engineering of these closures as well as the retrofit of the seal welded diaphragms in the field. (author)

  2. A closure for stochastic transport equations

    International Nuclear Information System (INIS)

    The problem of particle transport through a stochastic mixture of two immiscible materials is considered. The material mixing process is assumed to obey Markovian statistics. An ensemble average of this stochastic transport equations leads to two equations containing four different ensemble-averaged intensities. To close these equations to a set of two equations in two unknowns, certain rod geometry problems are considered. In this geometry, two distinct exact analyses are possible, namely a small correlation length analysis, and a non stochastic mean number of secondaries per collision analysis. The closure philosophy is to demand that the closed set of two equations reproduces these exact limiting behaviors. Numerical results are given which compare the predictions of this new closure with exact benchmark results as well as with the standard closure available in literature. (authors). 12 refs., 2 figs

  3. Development of an arid site closure plan

    International Nuclear Information System (INIS)

    This document describes the development of a prototype plan for the effective closure and stabilization of an arid low-level waste disposal site. This plan will provide demonstrated closure techniques for a trench in a disposal site at Los Alamos. The accuracy of modeling soil water storage by two hydrologic models, CREAMS and HELP, was tested by comparing simulation results with field measurements of soil moisture in eight experimental landfill cover systems having a range of well-defined soil profiles and vegetative covers. Regression analysis showed that CREAMS generally represented soil moisture more accurately than HELP simulations. Precautions for determining parameter values for model input and for interpreting simulation results are discussed. A specific example is presented showing how the field-validated hydrologic models can be used to develop a final prototype closure plan. 15 refs., 13 figs., 3 tabs

  4. Oxidative Stress Inhibits Vascular KATP Channels by S-Glutathionylation*

    OpenAIRE

    Yang, Yang; Shi, Weiwei; Cui, Ningren; Wu, Zhongying; Jiang, Chun

    2010-01-01

    The KATP channel is an important player in vascular tone regulation. Its opening and closure lead to vasodilation and vasoconstriction, respectively. Such functions may be disrupted in oxidative stress seen in a variety of cardiovascular diseases, while the underlying mechanism remains unclear. Here, we demonstrated that S-glutathionylation was a modulation mechanism underlying oxidant-mediated vascular KATP channel regulation. An exposure of isolated mesenteric rings to hydrogen peroxide (H2...

  5. Ion closure theory for high collisionality revisited

    International Nuclear Information System (INIS)

    According to analytical calculations of the ion collision operator, the ion-electron collision terms could be larger than the ion-ion collision terms. In the previous work [J.-Y. Ji and E. D. Held, Phys. Plasmas 20, 042114 (2013)], the ion-electron collision effects are diminished by the ion temperature change terms introduced from unlikely assumptions. In this work, the high-collisionality closures for ions are calculated without the temperature change terms. The ion-electron collision terms significantly modify existing closure coefficients

  6. Special closure for radioactive shipping container

    International Nuclear Information System (INIS)

    The objective of this program was to develop a special lid closure for radioactive material shipping containers, typically steel drums. Three closure techniques were designed, fabricated, and proven to be structurally adequate to protect 1000 lb when dropped 30 ft. The three designs were (1) a 6-in. lid extension (skirt), (2) a 6-in. inner lid, and (3) c-clamps used at the container/lid interface. Based upon structural integrity, economic impact, and minimal design change, the 6-in. lid extension is recommended

  7. Straight line closure of congenital macrostomia

    Directory of Open Access Journals (Sweden)

    Schwarz Richard

    2004-01-01

    Full Text Available The results of patients operated on by Nepal Cleft Lip and Palate Association (NECLAPA surgeons for congenital macrostomia were prospectively studied between January 2000 and December 2002. There were four males and three females with a median age of 10 years. Three had an associated branchial arch syndrome. In all patients an overlapping repair of orbicularis oris was done. Six patients had a straight line closure with excellent cosmetic results and one a Z-plasty with a more obvious scar. All had a normal appearing commissure. Overlapping orbicularis repair with straight line skin closure for this rare congenital anomaly is recommended.

  8. Patent Foramen Ovale: Stroke and Device Closure.

    Science.gov (United States)

    Suradi, Hussam S; Hijazi, Ziyad M

    2016-05-01

    Patent foramen ovale (PFO) is a common finding in healthy adults and has long been implicated in cryptogenic stroke. The pathogenesis is hypothesized to be caused by microemboli gaining access into the systemic circulation via a PFO. Proposed treatment options include medical therapy and/or PFO closure. Despite numerous studies and several randomized trials, much debate persists regarding the efficacy of this approach in reducing the risk of recurrent stroke in cryptogenic stroke patients. This article reviews the association between PFO and cryptogenic stroke, as well as current evidence for PFO device closure. PMID:27150171

  9. The Galois closure of Drinfeld modular towers

    DEFF Research Database (Denmark)

    Bassa, Alp; Beelen, Peter

    2011-01-01

    In this article we study Drinfeld modular curves X0(pn) associated to congruence subgroups Γ0(pn) of GL(2,Fq[T]) where p is a prime of Fq[T]. For n>r>0 we compute the extension degrees and investigate the structure of the Galois closures of the covers X0(pn)→X0(pr) and some of their variations. The...... results have some immediate implications for the Galois closures of two well-known optimal wild towers of function fields over finite fields introduced by Garcia and Stichtenoth, for which the modular interpretation was given by Elkies....

  10. Environmental considerations in mine closure planning

    International Nuclear Information System (INIS)

    Mine closure planning considers the best ways to plan and manage the environmental changes and socio-economic effects associated with the closing of mines. While the criteria for judging successful closures may vary, it is particularly important for physical, chemical and biological stability to be achieved and for final land use to be appropriate. Trust funds are increasingly favoured as a practical means of fulfilling the requirement for a financial surety and of ensuring that financial provision is available at the end of the mine's life. (author)

  11. Dealing with the safety paradox of delta-branches closure; a geomorphology study

    Science.gov (United States)

    Sloff, C.; Tromp, R.; Sieben, A.

    2013-12-01

    Closing off estuaries by dams is a conventional solution to reduce flood risks and salt intrusion in river deltas. However, if not all branches are closed, residual tidal currents develop or increase in connecting channels between the closed and open branches. These channels start to erode, causing bank instability and possible failure of levees. Hence, paradoxically, the intended increase in safety by this closure creates a new threat with increased flood risks. We illustrate this for existing channel erosion and dike stability problems in the Dutch Rhine River delta in the Netherlands, as well as for proposed future closure works in the Mekong River in Vietnam. Crucial for assessing and dealing with the erosion problems, is a proper prediction of flow conditions and of bed erodibility. The channels incise ancient deltaic deposits, consisting of diverse sections and layers of sand, clay and peat with diverse states of compaction. In the presented studies we show how we applied Delft3D to model the full delta, with all relevant dynamics and complex interactions between tidal flow and river discharges. For the Dutch situation, we simulated the long-term fate of the eroding interconnecting channels, applying a detailed description of subsurface heterogeneous erodibility (space and depth varying). Since these rivers are incising slowly in clay and peat beds covering highly-erodible sand layers, alternate sections occur of undersupplied ';fixed' beds, and of very deep scour holes. For the Vietnam case, we show how the location of a barrier and operation of gates, can be used to control both the salinity intrusion and channel erosion for the Mekong delta. Although the morphology studies for the Dutch delta with high-density data availability obviously justify a detailed Delft3D approach, it is shown that even in the Mekong delta with poor data quality, a coarse-grid large-scale Delft3D model can provide the answers necessary for planning the closure works and potential

  12. Scalping of light volatile sulfur compounds by wine closures.

    Science.gov (United States)

    Silva, Maria A; Jourdes, Michaël; Darriet, Philippe; Teissedre, Pierre-Louis

    2012-11-01

    Closures have an important influence on wine quality during aging in a bottle. Closures have a direct impact on oxygen exposure and on volatiles scavenging in wine. Model wine solution soaking assays of several types of closures (i.e., natural and technical cork stoppers, synthetic closures, screw caps) with two important wine volatile sulfur compounds led to a considerable reduction in their levels. After 25 days, cork closures and synthetic closures, to a lesser extent, have significantly scavenged hydrogen sulfide and dimethyl sulfide. These compounds have a determinant impact on wine aging bouquet, being largely responsible for "reduced off-flavors". Hydrogen sulfide levels are often not well correlated with the exposure of wine to oxygen or with the permeability of the closure. Its preferential sorption by some types of closures may explain that behavior. Scalping phenomenon should be taken into account when studying wine post-bottling development. PMID:23072649

  13. A constructive Galois connection between closure and interior

    OpenAIRE

    Ciraulo, Francesco; Sambin, Giovanni

    2011-01-01

    We construct a Galois connection between closure and interior operators on a given set. All arguments are intuitionistically valid. Our construction is an intuitionistic version of the classical correspondence between closure and interior operators via complement.

  14. Transcatheter Device Closure of Patent Ductus Arteriosus

    International Nuclear Information System (INIS)

    Objective: To determine the efficacy, safety and immediate complications encountered during percutaneous device closure of patent ductus arteriosus (PDA). Study Design: Case series. Place and Duration of Study: Department of Paediatric Cardiology, AFIC/NIHD, Rawalpindi, from January 2005 to December 2010. Methodology: Consecutive 500 patients who underwent attempted transcatheter PDA device closure were included in the study. Device type position, success of closure and complications were described as frequency percentage. Results: In 491 cases (98.2%), PDA was successfully occluded including 4 cases (0.8%) where devices were dislodged but retrieved and redeployed in Cath laboratory. PDA occluder devices used in 448 cases (91%) while coils (single or multiple) were used in 42 cases (8.5%) and in one case (0.2%) ASD occluder device was used to occlude the PDA. There were 09 (1.8%) unsuccessful cases, 06 (1.2%) were abandoned as ducts were considered unsuitable for device closure, 02 (0.4%) devices dislodged and needed surgical retrieval and one case (0.2%) was abandoned due to faulty equipment. The narrowest PDA diameter ranged from 0.5 - 14 mm with mean of 4.5 +- 2.4 mm. There was a single (0.2%) mortality. Conclusion: Transcatheter occlusion of PDA by coil or occluder device is an effective therapeutic option with high success rate. Complication rate is low in the hands of skilled operators yet paediatric cardiac surgical back-up cover is mandatory. (author)

  15. 50 CFR 635.28 - Closures.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Closures. 635.28 Section 635.28 Wildlife...., and reports positions with a vessel monitoring system, as specified in § 635.69. Additionally, legally... a vessel monitoring system as specified in § 635.69. NMFS may adjust the incidental catch...

  16. 300 Area Process Trenches Closure Plan

    Energy Technology Data Exchange (ETDEWEB)

    Luke, S.N.

    1994-08-15

    Since 1987, Westinghouse Hanford Company has been a major contractor to the US Department of Energy, Richland Operations Office and has served as co-operator of the 300 Area Process Trenches, the waste management unit addressed in this closure plan. For the purposes of the Resource Conservation and Recovery Act, Westinghouse Hanford Company is identified as ``co-operator.`` The 300 Area Process Trenches Closure Plan (Revision 0) consists of a Resource Conservation and Recovery Act Part A Dangerous Waste Permit Application, Form 3 and a Resource Conservation and Recovery Act Closure Plan. An explanation of the Part A Permit Application, Form 3 submitted with this document is provided at the beginning of the Part A Section. The closure plan consists of nine chapters and six appendices. The 300 Area Process Trenches received dangerous waste discharges from research and development laboratories in the 300 Area and from fuels fabrication processes. This waste consisted of state-only toxic (WT02), corrosive (D002), chromium (D007), spent halogenated solvents (F001, F002, and F003), and spent nonhalogented solvent (F005). Accurate records are unavailable concerning the amount of dangerous waste discharged to the trenches. The estimated annual quantity of waste (item IV.B) reflects the total quantity of both regulated and nonregulated waste water that was discharged to the unit.

  17. RECENT PROGRESS IN DOE WASTE TANK CLOSURE

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C

    2008-02-01

    The USDOE complex currently has over 330 underground storage tanks that have been used to process and store radioactive waste generated from the production of weapons materials. These tanks contain over 380 million liters of high-level and low-level radioactive waste. The waste consists of radioactively contaminated sludge, supernate, salt cake or calcine. Most of the waste exists at four USDOE locations, the Hanford Site, the Savannah River Site, the Idaho Nuclear Technology and Engineering Center and the West Valley Demonstration Project. A summary of the DOE tank closure activities was first issued in 2001. Since then, regulatory changes have taken place that affect some of the sites and considerable progress has been made in closing tanks. This paper presents an overview of the current regulatory changes and drivers and a summary of the progress in tank closures at the various sites over the intervening six years. A number of areas are addressed including closure strategies, characterization of bulk waste and residual heel material, waste removal technologies for bulk waste, heel residuals and annuli, tank fill materials, closure system modeling and performance assessment programs, lessons learned, and external reviews.

  18. Prosody, Phonology, and Parsing in Closure Ambiguities.

    Science.gov (United States)

    Warren, Paul; And Others

    1995-01-01

    This paper investigated the relationship of syntactic structure with prosodic and phonological information, focusing on distinctions between early and late closure sentences in terms both of intonational phrasing and of stress placement on stress shift items such as "Hong Kong." Contains 63 references. (MDM)

  19. Rocky Flats Closure Unit Cost Data

    International Nuclear Information System (INIS)

    The Rocky Flats Closure Project has completed the process of stabilizing residual nuclear materials, decommissioning nuclear facilities, remediating environmental media and closing the Rocky Flats Site (Site). The project cost approximately $4.1 B and included the decommissioning of over 700 structures including 5 major plutonium facilities and 5 major uranium facilities, shipping over 14,600 cubic meters of transuranic and 565,000 cubic meters of low level radioactive waste, and remediating a 385-acre industrial area and the surrounding land. Actual costs were collected for a large variety of closure activities. These costs can be correlated with metrics associated with the facilities and environmental media to capture cost factors from the project that could be applicable to a variety of other closure projects both within and outside of the Department of Energy's weapons complex. The paper covers four general topics: the process to correlate the actual costs and metrics, an example of the correlated data for one large sub-project, a discussion of the results, and the additional activities that are planned to correlate and make this data available to the public. The process to collect and arrange the project control data of the Closure Project relied on the actual Closure Project cost information. It was used to correlate these actual costs with the metrics for the physical work, such as building area or waste generated, to support the development of parametric cost factors. The example provides cost factors for the Industrial Sites Project. The discussion addresses the strengths and weaknesses of the data, followed by a section identifying future activities to improve and extend the analyses and integrate it within the Department's Environmental Cost Analysis System. (authors)

  20. Delayed physeal closure associated with castration in cats

    International Nuclear Information System (INIS)

    Radiographs of 152 cats under four years of age were examined for evidence of physeal closure. Radiographic closure was compared between entire male, castrated male, and female (neutered and entire] cats. Physeal closure in castrated males was delayed when compared to that of entire males

  1. 9 CFR 381.301 - Containers and closures.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Containers and closures. 381.301... Containers and closures. (a) Examination and cleaning of empty containers. (1) Empty containers, closures... and free of structural defects and damage that may affect product or container integrity. Such...

  2. 9 CFR 318.301 - Containers and closures.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Containers and closures. 318.301... Canning and Canned Products § 318.301 Containers and closures. (a) Examination and cleaning of empty containers. (1) Empty containers, closures, and flexible pouch roll stock shall be evaluated by...

  3. A Simple Method for Thoracotomy Closure Avoiding Intercostal Nerve Damage

    OpenAIRE

    Ufuk Cagirici

    2014-01-01

    It is well known that intercostal nerve damage during thoracotomy closure causes severe postoperative pain. A simple closure technique is proposed for intercostal nerve-sparing during thoracotomy opening and closure. We think that this maneuver may avoid intercostal nerve compression.

  4. On the orbits of -closure points of ultimately nonexpansive mappings

    Directory of Open Access Journals (Sweden)

    Kiang MoTak

    2006-01-01

    Full Text Available Let be a closed subset of a Banach space and an ultimately nonexpansive commutative semigroup of continuous selfmappings. If the -closure of is nonempty, then the closure of the orbit of any -closure point is a commutative topological group.

  5. Zinc Deficiency in Humans and its Amelioration

    Directory of Open Access Journals (Sweden)

    Yashbir Singh Shivay

    2015-01-01

    Full Text Available Zinc (Zn deficiency in humans has recently received considerable attention. Global mortality in children under 5 years of age in 2004 due to Zn deficiency was estimated at 4,53,207 as against 6,66,771 for vitamin A deficiency; 20,854 for iron deficiency and 3,619 for iodine deficiency. In humans 2800-3000 proteins contain Zn prosthetic group and Zn is an integral component of zinc finger prints that regulate DNA transcription. Zinc is a Type-2 nutrient, which means that its concentration in blood does not decrease in proportion of the Zn deficiency. Adverse effects of Zn deficiency vary with age: low weight gain, diarrhoea, aneroxia and neurobehavioral disturbances are observed in infants, while skin changes and dwarfism are frequent in toddlers and adolescents. Common manifestations of Zn deficiency among elderly include hypogeusia, chronic non-healing ulcers and recurrent infections.Ameliorative measures of Zn deficiency in humans can be classified in two groups, namely, nutraceutical and biofortification of food grains. Nutraceutical interventions include pharmaceutical supplements, dietary supplements and dietary diversification, while biofortification of food grains can be achieved by genetic modification (GM of crops or by agronomic techniques that include soil or/and foliar fertilization of crops.The major disadvantage of nutraceutical approaches is that the major beneficiaries are urban people and the poor rural masses that need adequate Zn nutrition most are left out. Genetic biofortification of food grains requires large amounts of funds and a fairly long-period of time. Further, a large number of countries have not yet accepted genetically modified (GM foods. On the other hand agronomic biofortification of food grains yields immediate effects and rural and urban people are equally benefitted. Our studies have shown that Zn concentration in cereals (rice, wheat etc and pulses can be considerably increased by soil or/and foliar

  6. Clinical Trial on the Incidence of Wound Infection and Patient Satisfaction After Stoma Closure: Comparison of Two Skin Closure Techniques

    OpenAIRE

    Yoon, Sang Il; Bae, Sun Mi; Namgung, Hwan; Park, Dong Guk

    2015-01-01

    Purpose Surgical site infection (SSI) is one of the most common complications that can occur after stoma closure. Reports have described differences in the incidence of wound infection depending on the skin closure technique, but there is no consensus on the ideal closure technique for a stoma wound. The aim of this study was to compare the incidence of SSI and the patient satisfaction between a circumferential purse-string approximation (CPA) and a primary linear closure (PC) of a stoma woun...

  7. Modelling of meander migration in an incised channel

    Institute of Scientific and Technical Information of China (English)

    Jianchun HUANG; Blair P GREIMANN; Timothy J RANDLE

    2014-01-01

    An updated linear computer model for meandering rivers with incision has been developed. The model simulates the bed topography, flow field, and bank erosion rate in an incised meandering channel. In a scenario where the upstream sediment load decreases (e.g., after dam closure or soil conservation), alluvial river experiences cross section deepening and slope flattening. The channel migration rate might be affected in two ways:decreased channel slope and steeped bank height. The proposed numerical model combines the traditional one-dimensional (1D) sediment transport model in simulating the channel erosion and the linear model for channel meandering. A non-equilibrium sediment transport model is used to update the channel bed elevation and gradations. A linear meandering model was used to calculate the channel alignment and bank erosion/accretion, which in turn was used by the 1D sediment transport model. In the 1D sediment transport model, the channel bed elevation and gradations are represented in each channel cross section. In the meandering model, the bed elevation and gradations are stored in two dimensional (2D) cells to represent the channel and terrain properties (elevation and gradation). A new method is proposed to exchange information regarding bed elevations and bed material fractions between 1D river geometry and 2D channel and terrain. The ability of the model is demonstrated using the simulation of the laboratory channel migration of Friedkin in which channel incision occurs at the upstream end.

  8. Convergence and Divergence of Signaling Events in Guard Cells during Stomatal Closure by Plant Hormones or Microbial Elicitors.

    Science.gov (United States)

    Agurla, Srinivas; Raghavendra, Agepati S

    2016-01-01

    Dynamic regulation of stomatal aperture is essential for plants to optimize water use and CO2 uptake. Stomatal opening or closure is accompanied by the modulation of guard cell turgor. Among the events leading to stomatal closure by plant hormones or microbial elicitors, three signaling components stand out as the major converging points. These are reactive oxygen species (ROS), cytosolic free Ca(2+), and ion channels. Once formed, the ROS and free Ca(2+) of guard cells regulate both downstream and upstream events. A major influence of ROS is to increase the levels of NO and cytosolic free Ca(2+) in guard cells. Although the rise in NO is an important event during stomatal closure, the available evidences do not support the description of NO as the point of convergence. The rise in ROS and NO would cause an increase of free Ca(2+) and modulate ion channels, through a network of events, in such a way that the guard cells lose K(+)/Cl(-)/anions. The efflux of these ions decreases the turgor of guard cells and leads to stomatal closure. Thus, ROS, NO, and cytosolic free Ca(2+) act as points of divergence. The other guard cell components, which are modulated during stomatal closure are G-proteins, cytosolic pH, phospholipids, and sphingolipids. However, the current information on the role of these components is not convincing so as to assign them as the points of convergence or divergence. The interrelationships and interactions of ROS, NO, cytosolic pH, and free Ca(2+) are quite complex and need further detailed examination. Our review is an attempt to critically assess the current status of information on guard cells, while emphasizing the convergence and divergence of signaling components during stomatal closure. The existing gaps in our knowledge are identified to stimulate further research. PMID:27605934

  9. Resource Conservation and Recovery Act Closure Plan for the Y-12 9409-5 Tank Storage Facility

    International Nuclear Information System (INIS)

    This document presents information on the closure of the Y-12 9409-5 Tank Storage Facility. Topics discussed include: facility description; closure history; closure performance standard; partial closure; maximum waste inventory; closure activities; schedule; and postclosure care

  10. A least squares closure approximation for liquid crystalline polymers

    Science.gov (United States)

    Sievenpiper, Traci Ann

    2011-12-01

    An introduction to existing closure schemes for the Doi-Hess kinetic theory of liquid crystalline polymers is provided. A new closure scheme is devised based on a least squares fit of a linear combination of the Doi, Tsuji-Rey, Hinch-Leal I, and Hinch-Leal II closure schemes. The orientation tensor and rate-of-strain tensor are fit separately using data generated from the kinetic solution of the Smoluchowski equation. The known behavior of the kinetic solution and existing closure schemes at equilibrium is compared with that of the new closure scheme. The performance of the proposed closure scheme in simple shear flow for a variety of shear rates and nematic polymer concentrations is examined, along with that of the four selected existing closure schemes. The flow phase diagram for the proposed closure scheme under the conditions of shear flow is constructed and compared with that of the kinetic solution. The study of the closure scheme is extended to the simulation of nematic polymers in plane Couette cells. The results are compared with existing kinetic simulations for a Landau-deGennes mesoscopic model with the application of a parameterized closure approximation. The proposed closure scheme is shown to produce a reasonable approximation to the kinetic results in the case of simple shear flow and plane Couette flow.

  11. Channel changes downstream from a dam

    Science.gov (United States)

    Hadley, R.F.; Emmett, W.W.

    1998-01-01

    A flood-control dam was completed during 1979 on Bear Creek, a small tributary stream to the South Platte River in the Denver, Colorado, area. Before and after dam closure, repetitive surveys between 1977 and 1992 at five cross sections downstream of the dam documented changes in channel morphology. During this 15-year period, channel width increased slightly, but channel depth increased by more than 40 percent. Within the study reach, stream gradient decreased and median bed material sizes coarsened from sand in the pools and fine gravel on the riffle to a median coarse gravel throughout the reach. The most striking visual change was from a sparse growth of streamside grasses to a dense growth of riparian woody vegetation.

  12. Choroidal physiology and primary angle closure disease.

    Science.gov (United States)

    Zhang, Xiulan; Wang, Wei; Aung, Tin; Jonas, Jost B; Wang, Ningli

    2015-01-01

    Primary angle closure disease (PACD), prevalent in Asian countries, is generally associated with a shallower anterior chamber, a shorter axial length, thicker lens, hyperopia, and female sex. Other physiologic factors, however, may be important, especially with regard to triggering acute primary angle closure. Thickening of the choroid has been demonstrated in untreated and treated, acute and chronic PACD eyes. Recently, there has been growing interest in studying the role of the choroid in the pathophysiology of PACD. The emergence of new imaging technology such as the enhanced depth imaging mode of spectral-domain optical coherence tomography and swept-source optical coherence tomography has contributed to understanding PACD pathologies. We summarize the functions of the choroid and choroidal changes in the pathogenesis of PACD, and discuss potential future developments. PMID:26164737

  13. Autonomic Closure for Large Eddy Simulation

    Science.gov (United States)

    King, Ryan; Hamlington, Peter; Dahm, Werner J. A.

    2015-11-01

    A new autonomic subgrid-scale closure has been developed for large eddy simulation (LES). The approach poses a supervised learning problem that captures nonlinear, nonlocal, and nonequilibrium turbulence effects without specifying a predefined turbulence model. By solving a regularized optimization problem on test filter scale quantities, the autonomic approach identifies a nonparametric function that represents the best local relation between subgrid stresses and resolved state variables. The optimized function is then applied at the grid scale to determine unknown LES subgrid stresses by invoking scale similarity in the inertial range. A priori tests of the autonomic approach on homogeneous isotropic turbulence show that the new approach is amenable to powerful optimization and machine learning methods and is successful for a wide range of filter scales in the inertial range. In these a priori tests, the autonomic closure substantially improves upon the dynamic Smagorinsky model in capturing the instantaneous, statistical, and energy transfer properties of the subgrid stress field.

  14. Colostomy closure: how to avoid complications

    OpenAIRE

    Bischoff, Andrea; Levitt, Marc A.; Taiwo A. Lawal; Peña, Alberto

    2010-01-01

    Purpose Colostomy is an operation frequently performed in pediatric surgery. Despite its benefits, it can produce significant morbidity. In a previous publication we presented our experience with the errors and complications that occurred during cases of colostomy creation. We now have focused in the morbidity related to the colostomy closure. The technical details that might have contributed to the minimal morbidity we experienced are described. Methods The medical records of 649 patients wh...

  15. Simple Case Treatment Planning: Diastema Closure.

    Science.gov (United States)

    Calamia, Vincent; Pantzis, Alexandria

    2015-07-01

    This article demonstrates the use of a smile evaluation form as an adjunct in arriving at diagnosis and developing a treatment plan for a patient desiring Diastema closure. It also shows the importance of the diagnostic wax-up for temporization and visualization of case outcome. The case also demonstrates the use of soft tissue lasers to create a gingival harmony that enhanced the resulting esthetics. Feldspathic porcelain was used for the final restorations because they provide optimal esthetics and translucency. PMID:26140972

  16. Calcined solids storage facility closure study

    Energy Technology Data Exchange (ETDEWEB)

    Dahlmeir, M.M.; Tuott, L.C.; Spaulding, B.C. [and others

    1998-02-01

    The disposal of radioactive wastes now stored at the Idaho National Engineering and Environmental Laboratory is currently mandated under a {open_quotes}Settlement Agreement{close_quotes} (or {open_quotes}Batt Agreement{close_quotes}) between the Department of Energy and the State of Idaho. Under this agreement, all high-level waste must be treated as necessary to meet the disposal criteria and disposed of or made road ready to ship from the INEEL by 2035. In order to comply with this agreement, all calcined waste produced in the New Waste Calcining Facility and stored in the Calcined Solids Facility must be treated and disposed of by 2035. Several treatment options for the calcined waste have been studied in support of the High-Level Waste Environmental Impact Statement. Two treatment methods studied, referred to as the TRU Waste Separations Options, involve the separation of the high-level waste (calcine) into TRU waste and low-level waste (Class A or Class C). Following treatment, the TRU waste would be sent to the Waste Isolation Pilot Plant (WIPP) for final storage. It has been proposed that the low-level waste be disposed of in the Tank Farm Facility and/or the Calcined Solids Storage Facility following Resource Conservation and Recovery Act closure. In order to use the seven Bin Sets making up the Calcined Solids Storage Facility as a low-level waste landfill, the facility must first be closed to Resource Conservation and Recovery Act (RCRA) standards. This study identifies and discusses two basic methods available to close the Calcined Solids Storage Facility under the RCRA - Risk-Based Clean Closure and Closure to Landfill Standards. In addition to the closure methods, the regulatory requirements and issues associated with turning the Calcined Solids Storage Facility into an NRC low-level waste landfill or filling the bin voids with clean grout are discussed.

  17. Notice of car park and road closures

    CERN Multimedia

    2006-01-01

    The arrival of one of the end caps of the CMS Tracker in Building 186 will result in the temporary closure of the following car parks: Building186: south entrance Building 613 Building 28 Building181: south entrance Building 600 Building 31 Route Oppenheimer The car parks concerned will be closed from Sunday 22 October until the evening of Monday 23 October. Thank you for your cooperation. PH-CMT Group Tel. 164569

  18. Notice of car park and road closures

    CERN Multimedia

    2006-01-01

    The arrival of one of the end caps of the CMS Tracker in Building 186 will result in the temporary closure of the following car parks: Building186: south entrance Building 613 Building 28 Building181: south entrance Building 600 Building 31 Route Oppenheimer The car parks concerned will be closed from Monday 30 October until the evening of Tuesday 31 October. Thank you for your cooperation. PH-CMT Group Tel. 164569

  19. Traveler Path Choice During Freeway Closure

    OpenAIRE

    Motamed, Moggan; Machemehl, Randy B.

    2013-01-01

    Construction activities and numbers of related work zones on urban freeways have grown significantly. The most problematic work zones occur on roads that are already fully loaded with traffic. The impact of work zones on mobility and safety makes success of the traffic control plan vital. Full freeway closures are sometimes implemented to expedite project completion and thereby reduce the cumulative impact of construction on travelers. Traffic diversion strategy is one way to improve the mana...

  20. Calcined solids storage facility closure study

    International Nuclear Information System (INIS)

    The disposal of radioactive wastes now stored at the Idaho National Engineering and Environmental Laboratory is currently mandated under a open-quotes Settlement Agreementclose quotes (or open-quotes Batt Agreementclose quotes) between the Department of Energy and the State of Idaho. Under this agreement, all high-level waste must be treated as necessary to meet the disposal criteria and disposed of or made road ready to ship from the INEEL by 2035. In order to comply with this agreement, all calcined waste produced in the New Waste Calcining Facility and stored in the Calcined Solids Facility must be treated and disposed of by 2035. Several treatment options for the calcined waste have been studied in support of the High-Level Waste Environmental Impact Statement. Two treatment methods studied, referred to as the TRU Waste Separations Options, involve the separation of the high-level waste (calcine) into TRU waste and low-level waste (Class A or Class C). Following treatment, the TRU waste would be sent to the Waste Isolation Pilot Plant (WIPP) for final storage. It has been proposed that the low-level waste be disposed of in the Tank Farm Facility and/or the Calcined Solids Storage Facility following Resource Conservation and Recovery Act closure. In order to use the seven Bin Sets making up the Calcined Solids Storage Facility as a low-level waste landfill, the facility must first be closed to Resource Conservation and Recovery Act (RCRA) standards. This study identifies and discusses two basic methods available to close the Calcined Solids Storage Facility under the RCRA - Risk-Based Clean Closure and Closure to Landfill Standards. In addition to the closure methods, the regulatory requirements and issues associated with turning the Calcined Solids Storage Facility into an NRC low-level waste landfill or filling the bin voids with clean grout are discussed

  1. Unusual Hernia in a Colostomy Closure Site

    OpenAIRE

    Howlader, Mohammad; Surendranathan, Thishi; Abdulaal, Yasser; James, Alan; Ali, Haythem; Nisar, Amir

    2009-01-01

    This is a case report of an interstitial hernia following previous transverse loop colostomy closure. There are no reported cases in the literature of gangrenous gall-bladder as the content of an interstitial hernia. This condition can present as a diagnostic challenge. We present a case with a previous reversal of a colostomy in the right upper quadrant presenting with a short history of a right iliac fossa mass and tenderness. Clinically, the patient was septic without any peritonitis. Subs...

  2. Stochastic particle acceleration and statistical closures

    International Nuclear Information System (INIS)

    In a recent paper, Maasjost and Elsasser (ME) concluded, from the results of numerical experiments and heuristic arguments, that the Bourret and the direct-interaction approximation (DIA) are ''of no use in connection with the stochastic acceleration problem'' because (1) their predictions were equivalent to that of the simpler Fokker-Planck (FP) theory, and (2) either all or none of the closures were in good agreement with the data. Here some analytically tractable cases are studied and used to test the accuracy of these closures. The cause of the discrepancy (2) is found to be the highly non-Gaussian nature of the force used by ME, a point not stressed by them. For the case where the force is a position-independent Ornstein-Uhlenbeck (i.e., Gaussian) process, an effective Kubo number K can be defined. For K << 1 an FP description is adequate, and conclusion (1) of ME follows; however, for K greater than or equal to 1 the DIA behaves much better qualitatively than the other two closures. For the non-Gaussian stochastic force used by ME, all common approximations fail, in agreement with (2)

  3. Phenomenology of convection-parameterization closure

    Directory of Open Access Journals (Sweden)

    J.-I. Yano

    2013-04-01

    Full Text Available Closure is a problem of defining the convective intensity in a given parameterization. In spite of many years of efforts and progress, it is still considered an overall unresolved problem. The present article reviews this problem from phenomenological perspectives. The physical variables that may contribute in defining the convective intensity are listed, and their statistical significances identified by observational data analyses are reviewed. A possibility is discussed for identifying a correct closure hypothesis by performing a linear stability analysis of tropical convectively coupled waves with various different closure hypotheses. Various individual theoretical issues are considered from various different perspectives. The review also emphasizes that the dominant physical factors controlling convection differ between the tropics and extra-tropics, as well as between oceanic and land areas. Both observational as well as theoretical analyses, often focused on the tropics, do not necessarily lead to conclusions consistent with our operational experiences focused on midlatitudes. Though we emphasize the importance of the interplays between these observational, theoretical and operational perspectives, we also face challenges for establishing a solid research framework that is universally applicable. An energy cycle framework is suggested as such a candidate.

  4. Deriving statistical closure from dynamical optimization

    Science.gov (United States)

    Turkington, Bruce

    2015-11-01

    Turbulence theorists have traditionally deduced statistical models by generating a hierarchy of moment equations and invoking some closure rules to truncate the hierarchy. In this talk a conceptually different approach to model reduction and statistical closure will be presented, and its implications for coarse-graining fluid turbulence will be indicated. The author has developed this method in the context of nonequilibrium statistical descriptions of Hamiltonian systems with many degrees of freedom. With respect to a chosen parametric statistical model, the lack-of-fit of model paths to the full dynamics is minimized in a time-integrated, mean-squared sense. This optimal closure method is applied to coarse-grain spectrally-truncated inviscid dynamics, including the Burgers-Hopf equation and incompressible two-dimensional flow, using the means and/or variances of low modes as resolved variables. The derived reduced dynamics for these test cases contain (1) scale-dependent dissipation which is not a local eddy viscosity, (2) modified nonlinear interactions between resolved modes, and (3) coupling between the mean and variance of each resolved mode. These predictions are validated against direct numerical simulations of ensembles for the fully resolved dynamics.

  5. Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.

    Science.gov (United States)

    Ogiyama, Takashi; Inoue, Makoto; Honda, Shugo; Yamada, Hiroyoshi; Watanabe, Toshihiro; Gotoh, Takayasu; Kiso, Tetsuo; Koakutsu, Akiko; Kakimoto, Shuichiro; Shishikura, Jun-ichi

    2014-12-15

    N-type calcium channels represent a promising target for the treatment of neuropathic pain. The selective N-type calcium channel blocker ziconotide ameliorates severe chronic pain but has a narrow therapeutic window and requires intrathecal administration. We identified tetrahydroisoquinoline derivative 1a as a novel potent N-type calcium channel blocker. However, this compound also exhibited potent inhibitory activity against hERG channels. Structural optimizations led to identification of (1S)-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-{[(1-hydroxycyclohexyl)methyl]amino}ethanone ((S)-1h), which exhibited high selectivity for hERG channels while retaining potency for N-type calcium channel inhibition. (S)-1h went on to demonstrate in vivo efficacy as an orally available N-type calcium channel blocker in a rat spinal nerve ligation model of neuropathic pain. PMID:25456079

  6. Glycine preconditioning to ameliorate pulmonary ischemia reperfusion injury in rats

    NARCIS (Netherlands)

    Sommer, Sebastian-Patrick; Sommer, Stefanie; Sinha, Bhanu; Leyh, Rainer G.

    2012-01-01

    This study examines the impact of glycine (Gly) preconditioning on ischemia reperfusion (IR)-induced pulmonary mitochondrial injury to research the previously, in pig lungs, demonstrated Gly-dependent amelioration of pulmonary IR injury. IR injury was induced in rat lungs by 30 min pulmonary hilum c

  7. Designing urban parks that ameliorate the effects of climate change

    NARCIS (Netherlands)

    Brown, R.D.; Vanos, J.; Kenny, N.; Lenzholzer, S.

    2015-01-01

    Many inhabitants of cities throughout the world suffer from health problems and discomfort that are caused by overheating of urban areas, and there is compelling evidence that these problems will be exacerbated by global climate change. Most cities are not designed to ameliorate these effects althou

  8. Morphological dynamics of an englacial channel

    Science.gov (United States)

    Vatne, Geir; Irvine-Fynn, Tristram D. L.

    2016-07-01

    Despite an interest in the hydraulic functioning of supraglacial and englacial channels over the last 4 decades, the processes and forms of such ice-bounded streams have remained poorly documented. Recent glaciological research has demonstrated the potential significance of so-called "cut-and-closure" streams, where englacial or subglacial flow paths are created from the long-term incision of supraglacial channels. These flow paths are reported to exhibit step-pool morphology, comprising knickpoints and/or knickzones, exaggerated in dimensions in comparison to supraglacial channels. However, little is known of the development of such channels' morphology. Here, we examine the spatial organisation of step pools and the upstream migration of steps, many of which form knickzones, with repeated surveys over a 10-year period in an englacial conduit in cold-based Austre Brøggerbreen, Svalbard. The observations show upstream step recession to be the dominant process for channel evolution. This is paralleled by an increase in average step height and conduit gradient over time. Characteristic channel-reach types and step-riser forms are consistently observed in each of the morphological surveys reported. We suggest that the formation of steps has a hydrodynamic origin, where step-pool geometry is more efficient for energy dissipation than meanders. The englacial channel system is one in rapid transition towards a quasi-equilibrium form within a decadal timescale. The evolution and recession of knickzones reported here result in the formation of a 37 m deep moulin shaft, suggesting that over time an incising supraglacial channel may evolve towards an englacial channel form exhibiting a stable end-point characterised by a singular vertical descent, which potentially can reach the glacier bed. This challenges the prevailing notions that crevasses or hydrofractures are needed to form deep moulins. Our observations highlight the need to further examine the adjustment processes

  9. Channel Networks

    Science.gov (United States)

    Rinaldo, Andrea; Rodriguez-Iturbe, Ignacio; Rigon, Riccardo

    This review proceeds from Luna Leopold's and Ronald Shreve's lasting accomplishments dealing with the study of random-walk and topologically random channel networks. According to the random perspective, which has had a profound influence on the interpretation of natural landforms, nature's resiliency in producing recurrent networks and landforms was interpreted to be the consequence of chance. In fact, central to models of topologically random networks is the assumption of equal likelihood of any tree-like configuration. However, a general framework of analysis exists that argues that all possible network configurations draining a fixed area are not necessarily equally likely. Rather, a probability P(s) is assigned to a particular spanning tree configuration, say s, which can be generally assumed to obey a Boltzmann distribution: P(s) % e^-H(s)/T, where T is a parameter and H(s) is a global property of the network configuration s related to energetic characters, i.e. its Hamiltonian. One extreme case is the random topology model where all trees are equally likely, i.e. the limit case for T6 4 . The other extreme case is T 6 0, and this corresponds to network configurations that tend to minimize their total energy dissipation to improve their likelihood. Networks obtained in this manner are termed optimal channel networks (OCNs). Observational evidence suggests that the characters of real river networks are reproduced extremely well by OCNs. Scaling properties of energy and entropy of OCNs suggest that large network development is likely to effectively occur at zero temperature (i.e. minimizing its Hamiltonian). We suggest a corollary of dynamic accessibility of a network configuration and speculate towards a thermodynamics of critical self-organization. We thus conclude that both chance and necessity are equally important ingredients for the dynamic origin of channel networks---and perhaps of the geometry of nature.

  10. Techniques for Abdominal Wall Closure after Damage Control Laparotomy: From Temporary Abdominal Closure to Early/Delayed Fascial Closure-A Review.

    Science.gov (United States)

    Huang, Qian; Li, Jieshou; Lau, Wan-Yee

    2016-01-01

    Open abdomen (OA) has been an effective treatment for abdominal catastrophes in traumatic and general surgery. However, management of patients with OA remains a formidable task for surgeons. The central goal of OA is closure of fascial defect as early as is clinically feasible without precipitating abdominal compartment syndrome. Historically, techniques such as packing, mesh, and vacuum-assisted closure have been developed to assist temporary abdominal closure, and techniques such as components separation, mesh-mediated traction, bridging fascial defect with permanent synthetic mesh, or biologic mesh have also been attempted to achieve early primary fascial closure, either alone or in combined use. The objective of this review is to present the challenges of these techniques for OA with a goal of early primary fascial closure, when the patient's physiological condition allows. PMID:26819597

  11. 3718-F Alkali Metal Treatment and Storage Facility Closure Plan

    Energy Technology Data Exchange (ETDEWEB)

    None

    1991-12-01

    Since 1987, Westinghouse Hanford Company has been a major contractor to the U.S. Department of Energy-Richland Operations Office and has served as co-operator of the 3718-F Alkali Metal Treatment and Storage Facility, the waste management unit addressed in this closure plan. The closure plan consists of a Part A Dangerous waste Permit Application and a RCRA Closure Plan. An explanation of the Part A Revision (Revision 1) submitted with this document is provided at the beginning of the Part A section. The closure plan consists of 9 chapters and 5 appendices. The chapters cover: introduction; facility description; process information; waste characteristics; groundwater; closure strategy and performance standards; closure activities; postclosure; and references.

  12. 3718-F Alkali Metal Treatment and Storage Facility Closure Plan

    International Nuclear Information System (INIS)

    Since 1987, Westinghouse Hanford Company has been a major contractor to the U.S. Department of Energy-Richland Operations Office and has served as co-operator of the 3718-F Alkali Metal Treatment and Storage Facility, the waste management unit addressed in this closure plan. The closure plan consists of a Part A Dangerous waste Permit Application and a RCRA Closure Plan. An explanation of the Part A Revision (Revision 1) submitted with this document is provided at the beginning of the Part A section. The closure plan consists of 9 chapters and 5 appendices. The chapters cover: introduction; facility description; process information; waste characteristics; groundwater; closure strategy and performance standards; closure activities; postclosure; and references

  13. Wound Closure and the Reconstructive Ladder in Plastic Surgery

    OpenAIRE

    Simman, Richard

    2009-01-01

    Wound closure requires deep understanding of wound physiology, anatomy, and the healing phase of the wound. The basic principles of wound closure, diabetes control, normal nutrition status, infection control, mechanical stress avoidance, and nursing care are all important elements in achieving healing of acute and chronic wounds. This goal is achievable only through the interdisciplinary approach to wound healing. A number of wound closure techniques are available to the plastic surgeon. This...

  14. Citalopram associated with acute angle-closure glaucoma: case report

    OpenAIRE

    Hassan Sabit; Thirumalai Srinivasa; Croos Robert; Davis Jane

    2005-01-01

    Abstract Background Acute angle-closure glaucoma is a rare complication in patients receiving anti-depressant treatment. In the following case, we report the development of acute angle closure glaucoma in a patient who overdosed on Citalopram, an antidepressant, and discuss the possible etiological mechanisms for the condition. Case presentation We report a 54 year old, Caucasian lady, with depression and alcohol dependence syndrome, who developed acute angle-closure glaucoma after an overdos...

  15. Closure concept for the Karlsruhe reprocessing plant

    International Nuclear Information System (INIS)

    The author presents an assessment of 50 years of Western safety technology, devoting - in view of currently still unresolved questions regarding the Federal Government's nuclear waste disposal concept - the greater part of his remarks to the closure of nuclear plants, with particular consideration of the Karlsruhe closure projects. The closure concept for the Karlsruhe Reprocessing Plant (KRP) comprises the complete removal of the plant, followed by recultivation of the site to form a 'green meadow'. To achieve this aim, the highly radioactive, liquid waste resulting from 20 years of operation (High Activity Waste Concentrate - HAWC) must first of all be disposed of. The complete project is therefore divided into the partprojects 'HAWC Disposal' and 'KRP-Regreening'. For this purpose, the Karlsruhe Vitrification Facility (KVF) will be built on the site of the KRP. In late 1998, first partial construction approval for building the KVF was granted, effective immediately, and was realised directly. A prototype vitrification facility (PVF) was built to scale 1:1 and, in May 1998, was put into 'radioactive cold' operation. The first three test phases have gone off according to plan, without any problems. The process of on-site vitrification should be completed in 2005. The author concludes his article with a plea for training nuclear technicians in Germany in the further, too, and for further promoting research and development in the field of nuclear technology, since even in the event of nuclear energy being abandoned, relevant expertise will still be required for several decades afterwards - we need only think of the ultimate-storage for radioactive waste. (orig.)

  16. Early closure of Bohunice V1 contested

    International Nuclear Information System (INIS)

    The early closure of the Bohunice V1 nuclear power plant following a time schedule that the Slovak government agreed with the EU three years ago is a political obligation of the government. The only objections to this plan so far have been related to the weakening of the generation base and economy of Slovenske elektrarne (SE), a.s. Neither the Nuclear Regulatory Authority of the Slovak Republic, nor the International Atomic Energy Agency, nor foreign experts preparing the closure of V1 in Jaslovske Bohunice have raised objections relating to increased security risks. Since he took up office last summer, the Minister of Economy Pavol Rusko has not hidden his personal interest in revising the agreement and extending the operation of the nuclear power plant. The fact that closing the power plant would have a negative impact on Slovakia's economy is not an argument good enough to persuade the original EU members. A proven security risk would be a better argument, especially as the operation of the V1 plant would not be extended literally - rather one of the reactors would work two years longer. Risk increased by 100%, a risk close to the level of acceptability in the EU - that is how in October he described the risks related to closure of V1 units according to the agreed time schedule, i.e. the first unit to be shut down by December 31, 2006 at the latest and the second unit by December 2008. The Minister based his opinion on a study prepared by the engineering and consulting company - Relko that assessed the risks V1 would represent after the first unit has been shut down. 'The only solution is to shut down both units at the same time', he concluded and in a comment addressed to the EU he added: 'If the EU has sincere intentions towards Slovakia, respects its security and does not wish it economic problems it will accept this'. (author)

  17. Economic and financial aspects of mine closure

    International Nuclear Information System (INIS)

    Today, mine reclamation is a key component to a successful mine plan. Most of the industrialized nations have recognized the need to make mining activities relatively environmentally friendly, if they want to continue to benefit from the economic gains from mineral resource development. Countries such as the United States, Canada, Australia and South Africa are leaders in the field and have implemented relatively sophisticated legislation to ensure environmentally correct mine closure. These countries rely on a combination of strict control strategies and economic penalties to ensure compliance. Yet, from the firm's perspective, reclamation activities are counterproductive as they cut into properties. In order to attract economic development and earn much needed economic capital, most of the rest of the world, particularly the developing countries, lack effective mine closure legislation. The traditional command and control type of legislation that is sometimes used is either vague and therefore avoided, or not enforced appropriately, resulting in an undesirable level of environmental degradation. With the use of case studies from Brazil, this article shows that direct controls are effective in some instances and not in others. It proposes that economic and financial tools may be more effective than the traditional direct controls in getting firms to comply with environmental standards, particularly in developing countries where environmental compliance is more difficult to achieve. It explains the use of performance bonding as one type of economic incentive that has proven to be an effective environmental policy in mine planning and closure. The authors additionally push beyond the typical style of performance bonds to introduce a flexible bonding and insurance system that allows governments to maintain strict environmental standards but limits firms financial exposure during the mining process. Such a system learns from the successes of the industrialized

  18. 100-N Area underground storage tank closures

    International Nuclear Information System (INIS)

    This report describes the removal/characterization actions concerning underground storage tanks (UST) at the 100-N Area. Included are 105-N-LFT, 182-N-1-DT, 182-N-2-DT, 182-N-3-DT, 100-N-SS-27, and 100-N-SS-28. The text of this report gives a summary of remedial activities. In addition, correspondence relating to UST closures can be found in Appendix B. Appendix C contains copies of Unusual Occurrence Reports, and validated sampling data results comprise Appendix D

  19. Multiple coil closure of isolated aortopulmonary collateral

    Directory of Open Access Journals (Sweden)

    Padhi Sumanta

    2010-01-01

    Full Text Available A 7-month-old girl was diagnosed to have large aortopulmonary collateral during evaluation for congestive heart failure. There was no other evidence of cardiopulmonary disease. The collateral was successfully closed with multiple coils delivered sequentially. We describe the issues associated during closure of the aortopulmonary collateral in this case. To the best of our knowledge, this is the first reported case of large aortopulmonary collateral presenting with heart failure in an otherwise structurally normal heart that was closed successfully with multiple coils delivered sequentially.

  20. Premature closure of the Trojan Nuclear Plant

    International Nuclear Information System (INIS)

    The premature closure of the Trojan Nuclear Plant is discussed in outline form. The topics discussed include: an overview of Trojan; events leading to shutdown decision; Trojan's lifetime O ampersand M performance; Trojan's Regulatory performance; historical Trojan regulatory versus economic performance; applicable Oregon law; least-cost planning process; 1992 least cost plan; 1993 LCP update; LCP limitations; comparative performance analysis; management assessments; Trojan O ampersand M analysis; steam generator issues; quantification of deficiencies; quantification of impact of steam generator degradation; 'net benefits' test; conclusions from net benefits analysis; total disallowances; and conclusions and ramifications

  1. 100-N Area underground storage tank closures

    Energy Technology Data Exchange (ETDEWEB)

    Rowley, C.A.

    1993-08-01

    This report describes the removal/characterization actions concerning underground storage tanks (UST) at the 100-N Area. Included are 105-N-LFT, 182-N-1-DT, 182-N-2-DT, 182-N-3-DT, 100-N-SS-27, and 100-N-SS-28. The text of this report gives a summary of remedial activities. In addition, correspondence relating to UST closures can be found in Appendix B. Appendix C contains copies of Unusual Occurrence Reports, and validated sampling data results comprise Appendix D.

  2. Lifting and wound closure with barbed sutures.

    Science.gov (United States)

    Mulholland, R Stephen; Paul, Malcolm D

    2011-07-01

    The advent of barbed sutures has been a novel and useful adjunct for the aesthetic plastic surgeon in properly selected patients. The deployment of a barbed suture minimizes the risks of cheese wiring and stress relaxation, facilitating the minimally invasive repositioning of soft tissue in the head and neck, as well as optimizing and enhancing traditionally long and potentially tedious procedures in body contouring. This article highlights the advances, advantages, and efficacy associated with the use of barbed sutures in lifting and wound closure. PMID:21824547

  3. ALA Inhibits ABA-induced Stomatal Closure via Reducing H2O2 and Ca(2+) Levels in Guard Cells.

    Science.gov (United States)

    An, Yuyan; Liu, Longbo; Chen, Linghui; Wang, Liangju

    2016-01-01

    5-Aminolevulinic acid (ALA), a newly proved natural plant growth regulator, is well known to improve plant photosynthesis under both normal and stressful conditions. However, its underlying mechanism remains largely unknown. Stomatal closure is one of the major limiting factors for photosynthesis and abscisic acid (ABA) is the most important hormone in provoking stomatal closing. Here, we showed that ALA significantly inhibited ABA-induced stomatal closure using wild-type and ALA-overproducing transgenic Arabidopsis (YHem1). We found that ALA decreased ABA-induced H2O2 and cytosolic Ca(2+) accumulation in guard cells with stomatal bioassay, laser-scanning confocal microscopy and pharmacological methods. The inhibitory effect of ALA on ABA-induced stomatal closure was similar to that of AsA (an important reducing substrate for H2O2 removal), CAT (a H2O2-scavenging enzyme), DPI (an inhibitor of the H2O2-generating NADPH oxidase), EGTA (a Ca-chelating agent), and AlCl3 (an inhibitor of calcium channel). Furthermore, ALA inhibited exogenous H2O2- or Ca(2+)-induced stomatal closure. Taken together, we conclude that ALA inhibits ABA-induced stomatal closure via reducing H2O2, probably by scavenging, and Ca(2+) levels in guard cells. Moreover, the inhibitive effect of ALA on ABA-induced stomatal closure was further confirmed in the whole plant. Finally, we demonstrated that ALA inhibits stomatal closing, but significantly improves plant drought tolerance. Our results provide valuable information for the promotion of plant production and development of a sustainable low-carbon society. PMID:27148309

  4. ALA Inhibits ABA-induced Stomatal Closure via Reducing H2O2 and Ca2+ Levels in Guard Cells

    Science.gov (United States)

    An, Yuyan; Liu, Longbo; Chen, Linghui; Wang, Liangju

    2016-01-01

    5-Aminolevulinic acid (ALA), a newly proved natural plant growth regulator, is well known to improve plant photosynthesis under both normal and stressful conditions. However, its underlying mechanism remains largely unknown. Stomatal closure is one of the major limiting factors for photosynthesis and abscisic acid (ABA) is the most important hormone in provoking stomatal closing. Here, we showed that ALA significantly inhibited ABA-induced stomatal closure using wild-type and ALA-overproducing transgenic Arabidopsis (YHem1). We found that ALA decreased ABA-induced H2O2 and cytosolic Ca2+ accumulation in guard cells with stomatal bioassay, laser-scanning confocal microscopy and pharmacological methods. The inhibitory effect of ALA on ABA-induced stomatal closure was similar to that of AsA (an important reducing substrate for H2O2 removal), CAT (a H2O2-scavenging enzyme), DPI (an inhibitor of the H2O2-generating NADPH oxidase), EGTA (a Ca-chelating agent), and AlCl3 (an inhibitor of calcium channel). Furthermore, ALA inhibited exogenous H2O2- or Ca2+-induced stomatal closure. Taken together, we conclude that ALA inhibits ABA-induced stomatal closure via reducing H2O2, probably by scavenging, and Ca2+ levels in guard cells. Moreover, the inhibitive effect of ALA on ABA-induced stomatal closure was further confirmed in the whole plant. Finally, we demonstrated that ALA inhibits stomatal closing, but significantly improves plant drought tolerance. Our results provide valuable information for the promotion of plant production and development of a sustainable low-carbon society. PMID:27148309

  5. PERFORMANCE OF A CONTAINMENT VESSEL CLOSURE FOR RADIOACTIVE GAS CONTENTS

    Energy Technology Data Exchange (ETDEWEB)

    Blanton, P.; Eberl, K.

    2010-07-09

    This paper presents a summary of the design and testing of the containment vessel closure for the Bulk Tritium Shipping Package (BTSP). This package is a replacement for a package that has been used to ship tritium in a variety of content configurations and forms since the early 1970s. The containment vessel closure incorporates features specifically designed for the containment of tritium when subjected to the normal and hypothetical conditions required of Type B radioactive material shipping Packages. The paper discusses functional performance of the containment vessel closure of the BTSP prototype packages and separate testing that evaluated the performance of the metallic C-Rings used in a mock BTSP closure.

  6. Design and analysis of PCRV core cavity closure

    International Nuclear Information System (INIS)

    Design requirements and considerations for a core cavity closure which led to the choice of a concrete closure with a toggle hold-down as the design for the Gas-Cooled Fast Breeder Reactor (GCFR) plant are discussed. A procedure for preliminary stress analysis of the closure by means of a three-dimensional finite element method is described. A limited parametric study using this procedure indicates the adequacy of the present closure design and the significance of radial compression developed as a result of inclined support reaction

  7. Blast loading of closures for use on shelters

    International Nuclear Information System (INIS)

    The work reported here is a part of a study to upgrade existing shelters in key worker and host areas. Objective is to determine closures suitable for shelters in these two areas. Ultimate failure of closures (breakout) was determined by dynamic loading tests performed at the BRL 2.44 m blast simulator. Test results are given for three types of closures. Load ratios of ultimate failure to allowable static design loads were found dynamically to be about four for the wood beam/plywood skin closures. This would make it acceptable for both host and key worker shelter areas

  8. Mixed Waste Management Facility closure at the Savannah River Site

    International Nuclear Information System (INIS)

    The Mixed Waste Management Facility of the Savannah River Plant received hazardous and solid low level radioactive wastes from 1972 until 1986. Because this facility did not have a permit to receive hazardous wastes, a Resource Conservation and Recovery Act closure was performed between 1987 and 1990. This closure consisted of dynamic compaction of the waste trenches and placement of a 3-foot clay cap, a 2-foot soil cover, and a vegetative layer. Operations of the waste disposal facility, tests performed to complete the closure design, and the construction of the closure cap are discussed herein

  9. Interim status of closure/post-closure plan for 183-H solar evaporation basins

    International Nuclear Information System (INIS)

    This report describes a plan for decommissioning several solar evaporation basins on the Hanford reservation. The document describes procedures for sampling during decommissioning and a plan for certification of the resulting completed landfill. Additional plans deal with the training, security of the site, and post-closure monitoring

  10. Channeling experiment

    International Nuclear Information System (INIS)

    Channeling of water flow and tracer transport in real fractures in a granite body at Stripa have been investigated experimentally. The experimental site was located 360 m below the ground level. Two kinds of experiments were performed. In the single hole experiments, 20 cm diameter holes were drilled about 2.5 m into the rock in the plane of the fracture. Specially designed packers were used to inject water into the fracture in 5 cm intervals all along the fracture trace in the hole. The variation of the injection flowrates along the fracture were used to determine the transmissivity variations in the fracture plane. Detailed photographs were taken from inside the hole and the visual fracture aperture was compared with the injection flowrates in the same locations. Geostatistical methods were used to evaluate the results. Five holes were measured in great detail. In addition 7 holes were drilled and scanned by simpler packer systems. A double hole experiment was performed where two parallel holes were drilled in the same fracture plane at nearly 2 m distance. Pressure pulse tests were made between the holes in both directions. Tracers were injected in 5 locations in one hole and monitored for in many locations in the other hole. The single hole experiment and the double hole experiment show that most of the fracture planes are tight but that there are open sections which form connected channels over distances of at least 2 meters. It was also found in the double hole experiment that the investigated fracture was intersected by at least one fracture between the two holes which diverted a large amount of the injected tracers to several distant locations at the tunnel wall. (authours)

  11. Vascular Closure Devices in Interventional Radiology Practice

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Rafiuddin, E-mail: rafiuddin.patel@ouh.nhs.uk [John Radcliffe Hospital, Department of Radiology (United Kingdom); Muller-Hulsbeck, Stefan, E-mail: muehue@diako.de [Diakonissen Hospital, Diagnostic and Interventional Radiology/Neuroradiology (Germany); Morgan, Robert, E-mail: robert.morgan@stgeorges.nhs.uk [St George’s Hospital, Department of Radiology (United Kingdom); Uberoi, Raman, E-mail: raman.uberoi@orh.nhs.uk [John Radcliffe Hospital, Department of Radiology (United Kingdom)

    2015-08-15

    Manual compression (MC) is a well-established technique for haemostasis following percutaneous arterial intervention. However, MC is labour and time intensive with potential limitations, particularly for patients who are coagulopathic, unable to comply with bed rest or obese and when large sheaths or anti-coagulants are used. There are a variety of vascular closure devices (VCDs) available to overcome these limitations. This review gives an overview of current VCDs, their mechanism of action, individual strengths and weaknesses, evidence base and utility in interventional radiology (IR) practice. The majority of the published evidence on VCDs is derived from patients undergoing cardiac interventions, which should be borne in mind when considering the applicability and transfer of this data for general IR practice. Overall, the evidence suggests that most VCDs are effective in achieving haemostasis with a similar rate of complications to MC although the complication profile associated with VCDs is distinct to that of MC. There is insufficient evidence to comparatively analyse the different types of VCDs currently available or reliably judge their cost-effectiveness. The interventional radiologist should have a thorough understanding of the available techniques for haemostasis and be able to identify and utilise the most appropriate strategy and closure technique for the individual patient.

  12. Accelerating cleanup. Paths to closure Hanford Site

    International Nuclear Information System (INIS)

    This document was previously referred to as the Draft 2006 Plan. As part of the DOE's national strategy, the Richland Operations Office's Paths to Closure summarizes an integrated path forward for environmental cleanup at the Hanford Site. The Hanford Site underwent a concerted effort between 1994 and 1996 to accelerate the cleanup of the Site. These efforts are reflected in the current Site Baseline. This document describes the current Site Baseline and suggests strategies for further improvements in scope, schedule and cost. The Environmental Management program decided to change the name of the draft strategy and the document describing it in response to a series of stakeholder concerns, including the practicality of achieving widespread cleanup by 2006. Also, EM was concerned that calling the document a plan could be misconstrued to be a proposal by DOE or a decision-making document. The change in name, however, does not diminish the 2006 vision. To that end, Paths to Closure retains a focus on 2006, which serves as a point in time around which objectives and goals are established

  13. IT SERVICES AVAILABILITY DURING CERN ANNUAL CLOSURE

    CERN Multimedia

    2002-01-01

    Mail, NICE 2000, Web, EDMS (in collaboration with EST Division), General purpose databases, lxbatch, lxplus, Automated tape devices, Castor, Backups, Campus Network, Remedy, Security and VPN services will be available during the CERN annual closure. Problems developing on these services should be addressed within about half a day except on Christmas and New Year evenings, December 25, 2002 and January 1st, 2003. All other services will be left running mostly unattended. No interruptions are scheduled but restoration of the service in case of failure cannot be guaranteed. It should be noted that the Helpdesk will be closed, that no file restores from backups will be possible and damaged tapes will not be processed. An operator service will be maintained and can be reached at extension 75011 or by email to computer.operations@cern.ch. Please remember to shutdown and power off any equipment in your office which is not foreseen to be used during the annual closure before you leave for the holiday.

  14. On closure parameter estimation in chaotic systems

    Directory of Open Access Journals (Sweden)

    J. Hakkarainen

    2012-02-01

    Full Text Available Many dynamical models, such as numerical weather prediction and climate models, contain so called closure parameters. These parameters usually appear in physical parameterizations of sub-grid scale processes, and they act as "tuning handles" of the models. Currently, the values of these parameters are specified mostly manually, but the increasing complexity of the models calls for more algorithmic ways to perform the tuning. Traditionally, parameters of dynamical systems are estimated by directly comparing the model simulations to observed data using, for instance, a least squares approach. However, if the models are chaotic, the classical approach can be ineffective, since small errors in the initial conditions can lead to large, unpredictable deviations from the observations. In this paper, we study numerical methods available for estimating closure parameters in chaotic models. We discuss three techniques: off-line likelihood calculations using filtering methods, the state augmentation method, and the approach that utilizes summary statistics from long model simulations. The properties of the methods are studied using a modified version of the Lorenz 95 system, where the effect of fast variables are described using a simple parameterization.

  15. SRS tank closure. Innovative technology summary report

    International Nuclear Information System (INIS)

    High-level waste (HLW) tank closure technology is designed to stabilize any remaining radionuclides and hazardous constituents left in a tank after bulk waste removal. Two Savannah River Site (SRS) HLW tanks were closed after cleansing and then filling each tank with three layers of grout. The first layer consists of a chemically reducing grout. The fill material has chemical properties that retard the movement of some radionuclides and chemical constituents. A layer of controlled low-strength material (CLSM), a self-leveling fill material, is placed on top of the reducing grout. CLSM provides sufficient strength to support the overbearing weight. The final layer is a free-flowing, strong grout similar to normal concrete. After the main tank cavity is filled, risers are filled with grout, and all waste transfer piping connected to the tank is isolated. The tank ventilation system is dismantled, and the remaining systems are isolated. Equipment that remains with the tank is filled with grout. The tank and ancillary systems are left in a state requiring only limited surveillance. Administrative procedures are in place to control land use and access. DOE eventually plans to remove all of its HLW storage tanks from service. These tanks are located at SRS, Hanford, and Idaho National Engineering and Environmental Laboratory. Low-activity waste storage tanks at Oak Ridge Reservation are also scheduled for closure

  16. Vascular Closure Devices in Interventional Radiology Practice.

    Science.gov (United States)

    Patel, Rafiuddin; Muller-Hulsbeck, Stefan; Morgan, Robert; Uberoi, Raman

    2015-08-01

    Manual compression (MC) is a well-established technique for haemostasis following percutaneous arterial intervention. However, MC is labour and time intensive with potential limitations, particularly for patients who are coagulopathic, unable to comply with bed rest or obese and when large sheaths or anti-coagulants are used. There are a variety of vascular closure devices (VCDs) available to overcome these limitations. This review gives an overview of current VCDs, their mechanism of action, individual strengths and weaknesses, evidence base and utility in interventional radiology (IR) practice. The majority of the published evidence on VCDs is derived from patients undergoing cardiac interventions, which should be borne in mind when considering the applicability and transfer of this data for general IR practice. Overall, the evidence suggests that most VCDs are effective in achieving haemostasis with a similar rate of complications to MC although the complication profile associated with VCDs is distinct to that of MC. There is insufficient evidence to comparatively analyse the different types of VCDs currently available or reliably judge their cost-effectiveness. The interventional radiologist should have a thorough understanding of the available techniques for haemostasis and be able to identify and utilise the most appropriate strategy and closure technique for the individual patient. PMID:25944150

  17. Closure plan for the proposed Millennium Project

    International Nuclear Information System (INIS)

    A $2.2 billion expansion of the current oil sands operation has been proposed by Suncor Energy Inc. The expansion would more than double the productive capacity of the present facility. As part of the application for this expansion, called Project Millennium, a comprehensive closure plan has been developed and filed by the Corporation. The Plan includes a systematic evaluation of the area to be developed, a description of the development activities planned, and the goals and objectives of the Corporation in re-establishing the landforms and ecosystems concurrently with running the operation. The Plan envisages surface contouring as early as practicable during the mine development, soil reconstruction, and re-establishment of vegetation, surface drainage and wetlands. The Corporation undertakes to monitor the performance of the reclaimed areas based on landform performance, the impact of chemical constituents on the landscape and ecosystem sustainability. An annual monitoring report assessing herbaceous vegetation growth, major species composition, tree and shrub survival and growth rate, groundwater conditions, amount of precipitation, the utility of constructed wetlands for treatment of reclamation area seepage and runoff waters, and wildlife population changes, will be prepared annually. A future research program associated with the Reclamation and Closure Plan will also examine the effectiveness of the reclamation drainage system as fish habitat, and the potential of the proposed end-pit lake to provide a viable aquatic ecosystem. 8 refs., 2 figs

  18. SRS tank closure. Innovative technology summary report

    Energy Technology Data Exchange (ETDEWEB)

    1999-08-01

    High-level waste (HLW) tank closure technology is designed to stabilize any remaining radionuclides and hazardous constituents left in a tank after bulk waste removal. Two Savannah River Site (SRS) HLW tanks were closed after cleansing and then filling each tank with three layers of grout. The first layer consists of a chemically reducing grout. The fill material has chemical properties that retard the movement of some radionuclides and chemical constituents. A layer of controlled low-strength material (CLSM), a self-leveling fill material, is placed on top of the reducing grout. CLSM provides sufficient strength to support the overbearing weight. The final layer is a free-flowing, strong grout similar to normal concrete. After the main tank cavity is filled, risers are filled with grout, and all waste transfer piping connected to the tank is isolated. The tank ventilation system is dismantled, and the remaining systems are isolated. Equipment that remains with the tank is filled with grout. The tank and ancillary systems are left in a state requiring only limited surveillance. Administrative procedures are in place to control land use and access. DOE eventually plans to remove all of its HLW storage tanks from service. These tanks are located at SRS, Hanford, and Idaho National Engineering and Environmental Laboratory. Low-activity waste storage tanks at Oak Ridge Reservation are also scheduled for closure.

  19. AMELIORATIVE EFFECTS OF TINOSPORA CORDIFOLIA IN SCIATICA PAIN INDUCED RATS

    OpenAIRE

    Thaakur Santhrani; Yaidikar Lavanya

    2012-01-01

    The present study was aimed at investigating the ameliorative effect of Tinospora cordifolia in sciatic nerve root Ligation -induced sciatica pain in rats. Adult male albino rats weighing 130-150gm were used for the study, and were divided into seven groups and ligation was performed on left sciatic nerve in group II to group VII. Tail cold-hyperalgesia, motor co-ordination tests, foot deformity, and total calcium levels were estimated to assess the extent of sciatica. Superoxide dismutase ...

  20. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms

    OpenAIRE

    Nyström, Alexander; Thriene, Kerstin; Mittapalli, Venugopal; Kern, Johannes S; Kiritsi, Dimitra; Dengjel, Jörn; Bruckner-Tuderman, Leena

    2015-01-01

    Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)—a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive. Here, we report an alternative evidence-based approach to ameliorate fibrosis and relieve symptoms in RDEB. Based on the findings that TGF-β activity is elevated in injured RDEB skin,...

  1. Use of Coffee Pulp and Minerals for Natural Soil Ameliorant

    OpenAIRE

    Pujiyanto Pujiyanto

    2007-01-01

    In coffee plantation, solid waste of coffee pulp is usually collected as heap nearby processing facilities for several months prior being used as compost. The practice is leading to the formation of odor and liquid which contaminate the environment. Experiments to evaluate the effect of natural soil ameliorant derived from coffee pulp and minerals were conducted at The Indonesian Coffee and Cocoa Research Institute in Jember, East Java. The experiments were intended to optimize the use of cof...

  2. Antibiotics can ameliorate circulatory complications of liver cirrhosis

    DEFF Research Database (Denmark)

    Madsen, Bjørn Stæhr; Schaffalitzky de Muckadell, Ove B

    2011-01-01

    Livercirrhosis can be complicated by a hyperdynamic circulatory syndrome. This is due to translocation of bacteria and bacterial product (bacterial DNA and endotoxins), which stimulate the splanchnic nitric oxide synthase and leads to splanchnic vasodilatation and haemodynamic derangement. This...... review focuses on how broad spectrum antibiotics can ameliorate the haemodynamic consequences of bacterial translocation. It is possible that the use of broad spectrum antibiotics in the future may be used to prevent other complications of liver cirrhosis than spontaneous bacterial peritonitis and...

  3. Response of Field Crops to Ameliorative Phosphorus Fertilization

    OpenAIRE

    KOVACEVIC, Vlado; Rastija, Mirta; KOMLJENOVIC, Ilija; BEGIC, Sabina; JOVIC, Jurica

    2014-01-01

    Different types of nutritional unbalances, including also low levels of plant available phosphorus (P), are often limiting factor of soil fertility in Croatia and in countries of the region, particularly in Bosnia and Herzegovina (B&H). Aim of this study was survey our recent investigations (eight stationary field experiments) of maize, soybean, wheat and barley responses to ameliorative P fertilization up to different levels (depending on the trial up to from 825 to 1580 kg P2O5 ha-1). Eithe...

  4. Biochar from commercially cultivated seaweed for soil amelioration

    Science.gov (United States)

    Roberts, David A.; Paul, Nicholas A.; Dworjanyn, Symon A.; Bird, Michael I.; de Nys, Rocky

    2015-04-01

    Seaweed cultivation is a high growth industry that is primarily targeted at human food and hydrocolloid markets. However, seaweed biomass also offers a feedstock for the production of nutrient-rich biochar for soil amelioration. We provide the first data of biochar yield and characteristics from intensively cultivated seaweeds (Saccharina, Undaria and Sargassum - brown seaweeds, and Gracilaria, Kappaphycus and Eucheuma - red seaweeds). While there is some variability in biochar properties as a function of the origin of seaweed, there are several defining and consistent characteristics of seaweed biochar, in particular a relatively low C content and surface area but high yield, essential trace elements (N, P and K) and exchangeable cations (particularly K). The pH of seaweed biochar ranges from neutral (7) to alkaline (11), allowing for broad-spectrum applications in diverse soil types. We find that seaweed biochar is a unique material for soil amelioration that is consistently different to biochar derived from ligno-cellulosic feedstock. Blending of seaweed and ligno-cellulosic biochar could provide a soil ameliorant that combines a high fixed C content with a mineral-rich substrate to enhance crop productivity.

  5. 40 CFR 267.142 - Cost estimate for closure.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Cost estimate for closure. 267.142... PERMIT Financial Requirements § 267.142 Cost estimate for closure. (a) The owner or operator must have at the facility a detailed written estimate, in current dollars, of the cost of closing the facility...

  6. 40 CFR 265.142 - Cost estimate for closure.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Cost estimate for closure. 265.142... DISPOSAL FACILITIES Financial Requirements § 265.142 Cost estimate for closure. (a) The owner or operator must have a detailed written estimate, in current dollars, of the cost of closing the facility...

  7. 40 CFR 264.142 - Cost estimate for closure.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Cost estimate for closure. 264.142... Financial Requirements § 264.142 Cost estimate for closure. (a) The owner or operator must have a detailed written estimate, in current dollars, of the cost of closing the facility in accordance with...

  8. Guinea pig ductus arteriosus. II - Irreversible closure after birth.

    Science.gov (United States)

    Fay, F. S.; Cooke, P. H.

    1972-01-01

    To investigate the mechanism underlying irreversibility of ductal closure after birth, studies were undertaken to determine the exact time course for the onset of irreversible closure of the guinea pig ductus arteriosus. Parallel studies of the reactivity of ductal smooth muscle to oxygen and studies of the postpartum cellular changes within the vessel were also carried out.

  9. WASTE PACKAGE OPERATIONS FY-99 CLOSURE METHODS REPORT

    International Nuclear Information System (INIS)

    The waste package (WP) closure weld development task is part of a larger engineering development program to develop waste package designs. The purpose of the larger waste package engineering development program is to develop nuclear waste package fabrication and closure methods that the Nuclear Regulatory Commission will find acceptable and will license for disposal of spent nuclear fuel (SNF), non-fuel components, and vitrified high-level waste within a Monitored Geologic Repository (MGR). Within the WP closure development program are several major development tasks, which, in turn, are divided into subtasks. The major tasks include: WP fabrication development, WP closure weld development, nondestructive examination (NDE) development, and remote in-service inspection development. The purpose of this report is to present the objectives, technical information, and work scope relating to the WP closure weld development.and NDE tasks and subtasks and to report results of the closure weld and NDE development programs for fiscal year 1999 (FY-99). The objective of the FY-99 WP closure weld development task was to develop requirements for closure weld surface and volumetric NDE performance demonstrations, investigate alternative NDE inspection techniques, and develop specifications for welding, NDE, and handling system integration. In addition, objectives included fabricating several flat plate mock-ups that could be used for NDE development, stress relief peening, corrosion testing, and residual stress testing

  10. Structural analysis of closure bolts for shipping casks

    Energy Technology Data Exchange (ETDEWEB)

    Mok, G.C.; Fischer, L.E.

    1993-04-01

    This paper identifies the active forces and moments in a closure bolt of a shipping cask. It examines the interactions of these forces/moments and suggest simplified methods for their analysis. The paper also evaluates the role that the forces and moments play in the structure integrity of the closure bolt and recommends stress limits and desirable practices to ensure its integrity.

  11. 77 FR 55895 - Permanent Closure of Cincinnati Blue Ash Airport

    Science.gov (United States)

    2012-09-11

    ... Federal Aviation Administration Permanent Closure of Cincinnati Blue Ash Airport AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of permanent closure of Cincinnati Blue Ash Airport (ISZ). SUMMARY: The... Cincinnati advising that on August 29, 2012, it was permanently closing Cincinnati Blue Ash Airport...

  12. Localization of Tight Closure in Two-Dimensional Rings

    Indian Academy of Sciences (India)

    Kamran Divaani-Aazar; Massoud Tousi

    2005-02-01

    It is shown that tight closure commutes with localization in any two-dimensional ring of prime characteristic if either is a Nagata ring or possesses a weak test element. Moreover, it is proved that tight closure commutes with localization at height one prime ideals in any ring of prime characteristic.

  13. On the normality of orbit closures which are hypersurfaces

    Indian Academy of Sciences (India)

    Nguyen Quang Loc

    2016-02-01

    Let be a quiver representation with non-zero admissible annihilator. In this paper, we prove the normality of the orbit closure $\\bar{\\mathcal{O}}_{N}$ when it is a hypersurface. The result thus gives new examples of normal orbit closures of quiver representations.

  14. 40 CFR 264.112 - Closure plan; amendment of plan.

    Science.gov (United States)

    2010-07-01

    ... operator of a hazardous waste management facility must have a written closure plan. In addition, certain... closure plan must include, at least: (1) A description of how each hazardous waste management unit at the....112 Section 264.112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

  15. Closure mechanisms of ventilated supercavities under steady and unsteady flows

    Science.gov (United States)

    Karn, Ashish; De, Rohan; Hong, Jiarong; Arndt, Roger E. A.

    2015-12-01

    The present work reports some interesting experimental results for ventilated supercavitation in steady and unsteady flows. First, a variety of closure modes obtained as a result of systematic variation in Froude number and air entrainment, are reported. The closure mechanisms were found to differ from the standard criterion reported in the literature. Further, the occurrence of a variety of stable and unstable closure mechanisms were discovered that have not been reported in the literature. Next, a hypothesis is presented to explain the cause behind these different closure mechanisms. The proposed hypothesis is then validated by synchronized high-speed imaging and pressure measurements inside and outside of the supercavity. These measurements show that the supercavity closure is a function of instantaneous cavitation number under unsteady flow conditions. (Research sponsored by Office of Naval Research, USA)

  16. Drop Tests for the 6M Specification Package Closure Investigation

    International Nuclear Information System (INIS)

    Results of tests of drum-type RAM packages employing conventional clamp-ring closures have caused concern within the DOE Complex over the Department of Transportation 6M Specification Package. To clarify these issues, the Savannah River Site's Radioactive Material Packaging Technology Group was commissioned to conduct a series of tests to determine the response of the clamp-ring closure to the regulatory Hypothetical Accident Condition drop tests, for packages at maximum allowable weight, 640 lb. Additionally, three enhanced closure designs were also tested: the Clamshell, plywood disk reinforcement, and J-Clip. The results of the tests showed that the standard closure was unable to retain its lid for both Center-of-Gravity-Over-Corner and Shallow-Angle cases, for the standard package, at its maximum allowed weight. Similar results were found for packages dropped from a reduced height. The Clamshell design provided the best performance of the enhanced closures

  17. Analysis of Valid Closure Property of Formal Language

    Directory of Open Access Journals (Sweden)

    Wenyu Chen

    2010-02-01

    Full Text Available This paper focuses on the basic operations of Chomsky’s languages. The validity and the effectiveness of some closure operations, such as union operator, product operator and Kleene Closure operator, are discussed in detail. The crosstalk problems in Context-Sensitive Languages (CSL and Phrase Structure Languages (PSL are analyzed, and a valuable method to solve this problem is presented by suing the alphabet of the operating languages. In addition, according to the valid closure property of regular languages (RL, a simple method to create a regular expression (RE is proposed. The closure property of the permutation operator in Context-Free Languages (CFL is proved and tested. In conclusion, by using our proposed methods, the exact type of a given language can be proved theoretically. By the way, the grammar to produce complex language can be created easy. Finally ,the constructing ε-NFA with the closure property is proved.

  18. The potential migration effect of rural hospital closures

    DEFF Research Database (Denmark)

    Sørensen, Jens Fyhn Lykke

    2008-01-01

    elsewhere. The aim of this study is to investigate whether rural hospital closures may lead to out-migration in a Danish setting and to investigate which socioeconomic groups would be most likely to migrate. Methods: The island of Ærø was selected as case study area. The island has one small hospital. By...... hospital and 29% would consider moving away if their hospital was closed. Multiple regression analyses showed that child families were most likely to consider moving away and elderly people were least likely to consider moving away. Conclusions: The study suggests that rural hospital closures may lead to......Rural hospital closures are high on the current health care agenda in Denmark. One raised concern is that rural hospital closures may further decrease population numbers in rural areas, as closures may induce some residents to move away from affected areas, i.e. closer to health care services...

  19. Fatigue Crack Closure Analysis Using Digital Image Correlation

    Science.gov (United States)

    Leser, William P.; Newman, John A.; Johnston, William M.

    2010-01-01

    Fatigue crack closure during crack growth testing is analyzed in order to evaluate the critieria of ASTM Standard E647 for measurement of fatigue crack growth rates. Of specific concern is remote closure, which occurs away from the crack tip and is a product of the load history during crack-driving-force-reduction fatigue crack growth testing. Crack closure behavior is characterized using relative displacements determined from a series of high-magnification digital images acquired as the crack is loaded. Changes in the relative displacements of features on opposite sides of the crack are used to generate crack closure data as a function of crack wake position. For the results presented in this paper, remote closure did not affect fatigue crack growth rate measurements when ASTM Standard E647 was strictly followed and only became a problem when testing parameters (e.g., load shed rate, initial crack driving force, etc.) greatly exceeded the guidelines of the accepted standard.

  20. Using DNS and Statistical Learning to Model Bubbly Channel Flow

    Science.gov (United States)

    Ma, Ming; Lu, Jiacai; Tryggvason, Gretar

    2015-11-01

    The transient evolution of laminar bubbly flow in a vertical channel is examined by direct numerical simulation (DNS). Nearly spherical bubbles, initially distributed evenly in a fully developed parabolic flow, are driven relatively quickly to the walls, where they increase the drag and reduce the flow rate on a longer time scale. Once the flow rate has been decreased significantly, some of the bubbles move back into the channel interior and the void fraction there approaches the value needed to balance the weight of the mixture and the imposed pressure gradient. A database generated by averaging the DNS results is used to model the closure terms in a simple model of the average flow. Those terms relate the averaged lateral flux of the bubbles, the velocity fluctuations and the averaged surface tension force to the fluid shear, the void fraction and its gradient, as well as the distance to the nearest wall. An aggregated neural network is used for the statistically leaning of unknown closures, and closure relationships are tested by following the evolution of bubbly channel flow with different initial conditions. It is found that the model predictions are in reasonably good agreement with DNS results. Supported by NSF.

  1. Spontaneous closure of midline diastema following frenectomy

    Directory of Open Access Journals (Sweden)

    Koora Kiran

    2007-03-01

    Full Text Available Maxillary midline diastema is a common aesthetic problem in mixed and early permanent dentitions. The space can occur either as a transient malocclusion or created by developmental, pathological or iatrogenical factors. Many innovative therapies varying from restorative procedures such as composite build-up to surgery (frenectomies and orthodontics are available. Although literature says every frenectomy procedure should be preceded by orthodontic treatment, we opted for frenectomy technique without any orthodontic intervention. Presented herewith is a case report of a 9-year-old girl with a high frenal attachment that had caused spacing of the maxillary central incisors. A spontaneous closure of the midline diastema was noted within 2 months following frenectomy. The patient was followed up for 4 months after which the space remained closed and there was no necessity for an orthodontic treatment at a later stage.

  2. Notice of car park and road closures

    CERN Multimedia

    2006-01-01

    The transfer of the two HF CMS detectors between Hall 186 and Point 5 (a convoy measuring 64 metres in length and weighing 440 tonnes) will result in the temporary closure of the following car parks: Building186: south entrance Building 613 Building 28 Building181 south entrance Building 600 Building 31 Route OPPENHEIMER The car parks concerned will be closed from Sunday 2 July until the evening of Tuesday 4 July and from Sunday 9 July until the evening of Tuesday 11 July 2006.Route FEYNMAN is also expected to be closed to traffic from mid-morning on Monday 3 July until the evening of Tuesday 4 July and from mid-morning on Monday 10 July until the evening of Tuesday 11 July (possible deviation via route FERMI and route RUTHERFORD).Thank you for your cooperation. TS-IC GroupTel. 163380 - 164043

  3. Notice of car park and road closures

    CERN Multimedia

    2006-01-01

    The transfer of the two HF CMS detectors between Hall 186 and Point 5 (a convoy measuring 64 metres in length and weighing 440 tonnes) will result in the temporary closure of the following car parks: Building186: south entrance Building 613 Building 28 Building181 south entrance Building 600 Building 31 Route OPPENHEIMER The car parks concerned will be closed from Sunday 2 July until the evening of Tuesday 4 July and from Sunday 9 July until the evening of Tuesday 11 July 2006. Route FEYNMAN is also expected to be closed to traffic from mid-morning on Monday 3 July until the evening of Tuesday 4 July and from mid-morning on Monday 10 July until the evening of Tuesday 11 July (possible deviation via route FERMI and route RUTHERFORD). Thank you for your cooperation. TS-IC Group Tel. 163380 - 164043

  4. Occupational closure in nursing work reconsidered

    DEFF Research Database (Denmark)

    Traynor, Michael; Nissen, Nina; Lincoln, Carol;

    2015-01-01

    In healthcare, occupational groups have adopted tactics to maintain autonomy and control over their areas of work. Witz described a credentialist approach to occupational closure adopted by nursing in the United Kingdom during the 19th and early 20th centuries. However, the recent advancement......, while nurses abandon it for largely administrative roles. We conclude that the participants are the not unwilling agents of a managerially led project to reshape the workforce that cuts across existing occupational boundaries....... = 59). The aim was to examine how these workers positioned themselves as professionals and accounted for professional boundaries. A thematic analysis revealed a complex situation in which participants were divided between articulating an acceptance of a subordinate role within traditional occupational...

  5. Closure head for a nuclear reactor

    International Nuclear Information System (INIS)

    A closure head for a nuclear reactor includes a stationary outer ring integral with the reactor vessel with a first rotatable plug disposed within the stationary outer ring and supported from the stationary outer ring by a bearing assembly. A sealing system is associated with the bearing assembly to seal the annulus defined between the first rotatable plug and the stationary outer ring. The sealing system comprises tubular seal elements disposed in the annulus with load springs contacting the tubular seal elements so as to force the tubular seal elements against the annulus in a manner to seal the annulus. The sealing system also comprises a sealing fluid which is pumped through the annulus and over the tubular seal elements causing the load springs to compress thereby reducing the friction between the tubular seal elements and the rotatable components while maintaining a gas-tight seal therebetween

  6. 300 Area solvent evaporator closure plan

    International Nuclear Information System (INIS)

    This document describes activities for the closure of a dangerous waste treatment tank facility, owned and operated by the US Department of Energy-Richland Operations Office (DOE-RL) and co-operated by the Westinghouse Hanford Company (Westinghouse Hanford). This tank treatment facility is the 300 Area Solvent Evaporator (300 ASE), which was located in the 300 Area of the Hanford Site from 1975 to 1986, and was managed for the DOE-RL by UNC Nuclear Industries, Incorporated. The 300 ASE evaporator unit was a modified load lugger (dumpster) in which solvent wastes were evaporated, and the adjacent 333 East Concrete Pad, where 55-gallon barrels of waste solvents were temporarily stored while awaiting liquid transfers into the evaporator. 26 refs., 14 figs., 6 tabs

  7. Dynamics of electrochemical flows 3 Closure models

    CERN Document Server

    Xu, Chengjun

    2013-01-01

    The electrolyte (comprising of solute ions and solvents) flow-through the porous media is frequently encountered in nature or in many engineering applications, such as the electrochemical systems, manufacturing of composites, oil production, geothermal engineering, nuclear thermal disposal, soil pollution. Our previous work derived the interfacial interaction terms between the solid and the fluid, which can be used to investigate the details of transports of mass, heat, electric flied, potential, or momentum in the process of the electrochemical flows-through porous electrode. In this work, we establish the closure models for these interfacial interaction terms to close the governing equations from mathematical algebra. The interfacial interaction terms regard to the electric field, potential and electric force are firstly revealed. Our new theory provides a new approach to describe the electrochemical flows-through porous media.

  8. Automated Fuel Element Closure Welding System

    International Nuclear Information System (INIS)

    The Automated Fuel Element Closure Welding System is a robotic device that will load and weld top end plugs onto nuclear fuel elements in a highly radioactive and inert gas environment. The system was developed at Argonne National Laboratory-West as part of the Fuel Cycle Demonstration. The welding system performs four main functions, it (1) injects a small amount of a xenon/krypton gas mixture into specific fuel elements, and (2) loads tiny end plugs into the tops of fuel element jackets, and (3) welds the end plugs to the element jackets, and (4) performs a dimensional inspection of the pre- and post-welded fuel elements. The system components are modular to facilitate remote replacement of failed parts. The entire system can be operated remotely in manual, semi-automatic, or fully automatic modes using a computer control system. The welding system is currently undergoing software testing and functional checkout

  9. Comparing over-the-scope clip versus endoloop and clips (KING closure) for access site closure: a randomized experimental study

    Czech Academy of Sciences Publication Activity Database

    Martínek, J.; Ryska, O.; Tučková, I.; Filípková, T.; Doležel, R.; Juhás, Štefan; Motlík, Jan; Zavoral, M.; Ryska, M.

    2013-01-01

    Roč. 27, č. 4 (2013), s. 1203-1210. ISSN 0930-2794 R&D Projects: GA MZd NS9994 Institutional research plan: CEZ:AV0Z50450515 Keywords : NOTES * gastrotomy closure * rectotomy closure Subject RIV: FJ - Surgery incl. Transplants Impact factor: 3.313, year: 2013

  10. 303-K Storage Facility closure plan

    International Nuclear Information System (INIS)

    Recyclable scrap uranium with zircaloy-2 and copper silicon alloy, uranium-titanium alloy, beryllium/zircaloy-2 alloy, and zircaloy-2 chips and fines were secured in concrete billets (7.5-gallon containers) in the 303-K Storage Facility, located in the 300 Area. The beryllium/zircaloy-2 alloy and zircaloy-2 chips and fines are designated as mixed waste with the characteristic of ignitability. The concretion process reduced the ignitability of the fines and chips for safe storage and shipment. This process has been discontinued and the 303-K Storage Facility is now undergoing closure as defined in the Resource Conservation and Recovery Act (RCRA) of 1976 and the Washington Administrative Code (WAC) Dangerous Waste Regulations, WAC 173-303-040. This closure plan presents a description of the 303-K Storage Facility, the history of materials and waste managed, and the procedures that will be followed to close the 303-K Storage Facility. The 303-K Storage Facility is located within the 300-FF-3 (source) and 300-FF-5 (groundwater) operable units, as designated in the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) (Ecology et al. 1992). Contamination in the operable units 300-FF-3 and 300-FF-5 is scheduled to be addressed through the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 remedial action process. Therefore, all soil remedial action at the 304 Facility will be conducted as part of the CERCLA remedial action of operable units 300-FF-3 and 300-FF-5

  11. Laboratory testing of closure cap repair techniques

    International Nuclear Information System (INIS)

    Landfill design requires a low permeability closure cap as well as a low permeability liner. The Savannah River Site, in South Carolina, has approximately 85 acres of mixed waste landfills covered with compacted kaolin clay. Maintaining low permeability of the clay cap requires both that the permeability of the compacted clay itself remain low and that the integrity of the barrier be maintained. Barrier breaches typically result from penetration by roots or animals, and especially cracks caused by uneven settling or desiccation. In this study, clay layers, 0.81 m in diameter and 7.6 cm thick, were compacted in 7 lysimeters to simulate closure caps. The hydraulic conductivity of each layer was measured, and the compacted clay layers (CCL's) were cracked by drying. Then various repair techniques were applied and the effectiveness of each repair was assessed by remeasuring the hydraulic conductivity. Finally the repaired CCL was again dried and measured to determine how the repair responded to the conditions that caused the original failure. For a full report of this investigation see Persoff et al. Six repair techniques have been tested, four of which involve the use of injectable barrier liquids colloidal silica (CS) and polysiloxane (PSX) described below: (I) covering the crack with a bentonite geosynthetic clay liner (GCL), (ii) recompaction of new kaolinite at STD+3 moisture content joined to existing kaolinite that had dried and shrunk, (iii) direct injection of colloidal silica to a crack, (iv) injection of colloidal silica (CS) to wells in an overlying sand layer, (v) direct injection of polysiloxane to a crack, and (vi), injection of polysiloxane (PSX) to wells in an overlying soil layer

  12. ICPP tank farm closure study. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Spaulding, B.C.; Gavalya, R.A.; Dahlmeir, M.M. [and others

    1998-02-01

    The disposition of INEEL radioactive wastes is now under a Settlement Agreement between the DOE and the State of Idaho. The Settlement Agreement requires that existing liquid sodium bearing waste (SBW), and other liquid waste inventories be treated by December 31, 2012. This agreement also requires that all HLW, including calcined waste, be disposed or made road ready to ship from the INEEL by 2035. Sodium bearing waste (SBW) is produced from decontamination operations and HLW from reprocessing of SNF. SBW and HLW are radioactive and hazardous mixed waste; the radioactive constituents are regulated by DOE and the hazardous constituents are regulated by the Resource Conservation and Recovery Act (RCRA). Calcined waste, a dry granular material, is produced in the New Waste Calcining Facility (NWCF). Two primary waste tank storage locations exist at the ICPP: Tank Farm Facility (TFF) and the Calcined Solids Storage Facility (CSSF). The TFF has the following underground storage tanks: four 18,400-gallon tanks (WM 100-102, WL 101); four 30,000-gallon tanks (WM 103-106); and eleven 300,000+ gallon tanks. This includes nine 300,000-gallon tanks (WM 182-190) and two 318,000 gallon tanks (WM 180-181). This study analyzes the closure and subsequent use of the eleven 300,000+ gallon tanks. The 18,400 and 30,000-gallon tanks were not included in the work scope and will be closed as a separate activity. This study was conducted to support the HLW Environmental Impact Statement (EIS) waste separations options and addresses closure of the 300,000-gallon liquid waste storage tanks and subsequent tank void uses. A figure provides a diagram estimating how the TFF could be used as part of the separations options. Other possible TFF uses are also discussed in this study.

  13. ICPP tank farm closure study. Volume 1

    International Nuclear Information System (INIS)

    The disposition of INEEL radioactive wastes is now under a Settlement Agreement between the DOE and the State of Idaho. The Settlement Agreement requires that existing liquid sodium bearing waste (SBW), and other liquid waste inventories be treated by December 31, 2012. This agreement also requires that all HLW, including calcined waste, be disposed or made road ready to ship from the INEEL by 2035. Sodium bearing waste (SBW) is produced from decontamination operations and HLW from reprocessing of SNF. SBW and HLW are radioactive and hazardous mixed waste; the radioactive constituents are regulated by DOE and the hazardous constituents are regulated by the Resource Conservation and Recovery Act (RCRA). Calcined waste, a dry granular material, is produced in the New Waste Calcining Facility (NWCF). Two primary waste tank storage locations exist at the ICPP: Tank Farm Facility (TFF) and the Calcined Solids Storage Facility (CSSF). The TFF has the following underground storage tanks: four 18,400-gallon tanks (WM 100-102, WL 101); four 30,000-gallon tanks (WM 103-106); and eleven 300,000+ gallon tanks. This includes nine 300,000-gallon tanks (WM 182-190) and two 318,000 gallon tanks (WM 180-181). This study analyzes the closure and subsequent use of the eleven 300,000+ gallon tanks. The 18,400 and 30,000-gallon tanks were not included in the work scope and will be closed as a separate activity. This study was conducted to support the HLW Environmental Impact Statement (EIS) waste separations options and addresses closure of the 300,000-gallon liquid waste storage tanks and subsequent tank void uses. A figure provides a diagram estimating how the TFF could be used as part of the separations options. Other possible TFF uses are also discussed in this study

  14. Delayed primary closure in open abdomen with stoma using dynamic closure system

    OpenAIRE

    Suarez-Grau, Juan Manuel; Guadalajara Jurado, Juan Francisco; Gómez Menchero, Julio; Bellido Luque, Juan Antonio

    2015-01-01

    Background The situation of abdominal sepsis secondary to colonic perforation sometimes forces treat the patient with multiple interventions in the open abdomen (OA) context. Correct management of OA is important to restore the patient’s clinical situation and to avoid further complications of the abdominal wall. Delayed primary closure of the abdomen using a dynamic and progressive traction is a relatively new technique for treating the OA. Case presentation We report the case of a 50 year o...

  15. A numerical model for meltwater channel evolution in glaciers

    Directory of Open Access Journals (Sweden)

    A. H. Jarosch

    2011-10-01

    Full Text Available Meltwater channels form an integral part of the hydrological system of a glacier. Better understanding of how meltwater channels develop and evolve is required to fully comprehend supraglacial and englacial meltwater drainage. Incision of supraglacial stream channels and subsequent roof closure by ice deformation has been proposed in recent literature as a possible englacial conduit formation process. Field evidence for supraglacial stream incision has been found in Svalbard and Nepal. In Iceland, where volcanic activity provides meltwater with temperatures above 0 °C, rapid enlargement of supraglacial channels has been observed. By coupling, for the first time, a numerical ice dynamic model to a hydraulic model which includes heat transfer, we investigate the evolution of meltwater channels and their incision behaviour. We present results for different, constant meltwater fluxes, different channel slopes, different meltwater temperatures as well as temporal variations in meltwater flux. The key parameters governing incision rate and depth are the channel slope and the meltwater temperature loss to the ice. Meltwater flux controls channel width and to a lesser degree incision behaviour. Calculated Nusselt numbers suggest that turbulent forced convection is the main heat transfer mechanism in the studied meltwater channels.

  16. Using field inversion to quantify functional errors in turbulence closures

    Science.gov (United States)

    Singh, Anand Pratap; Duraisamy, Karthik

    2016-04-01

    A data-informed approach is presented with the objective of quantifying errors and uncertainties in the functional forms of turbulence closure models. The approach creates modeling information from higher-fidelity simulations and experimental data. Specifically, a Bayesian formalism is adopted to infer discrepancies in the source terms of transport equations. A key enabling idea is the transformation of the functional inversion procedure (which is inherently infinite-dimensional) into a finite-dimensional problem in which the distribution of the unknown function is estimated at discrete mesh locations in the computational domain. This allows for the use of an efficient adjoint-driven inversion procedure. The output of the inversion is a full-field of discrepancy that provides hitherto inaccessible modeling information. The utility of the approach is demonstrated by applying it to a number of problems including channel flow, shock-boundary layer interactions, and flows with curvature and separation. In all these cases, the posterior model correlates well with the data. Furthermore, it is shown that even if limited data (such as surface pressures) are used, the accuracy of the inferred solution is improved over the entire computational domain. The results suggest that, by directly addressing the connection between physical data and model discrepancies, the field inversion approach materially enhances the value of computational and experimental data for model improvement. The resulting information can be used by the modeler as a guiding tool to design more accurate model forms, or serve as input to machine learning algorithms to directly replace deficient modeling terms.

  17. Channel strategy adaptation

    OpenAIRE

    Rangan, V. Kasturi; Nueno, Jose L

    1999-01-01

    Using transaction cost theory, considerable research in marketing has focused on the conditions under which firms would use direct or vertically integrated versus indirect or arms length channels of distribution. Data from the field, however, indicate that channel configurations are more varied and complex, with multiple channels and composite channels being just as common as direct and indirect channels. In an attempt to explain this variety, this paper revisits the influence on channel stru...

  18. Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?

    DEFF Research Database (Denmark)

    Madsen, Lars Siim; Christophersen, Palle; Olesen, Søren-Peter

    2005-01-01

    Voltage- and Ca(2+)-dependent K(+) channels in the membrane of both T and B lymphocytes are important for the cellular immune response. In the current issue of the European Journal of Immunology, Reich et al. demonstrate that selective blockade of the intermediate-conductance Ca(2+)-activated K(+...... of new immune-suppressant drugs for the treatment of autoimmune diseases.......(+) channel (the IK channel encoded by the KCNN4 gene) prevents cytokine production in the spinal chord and ameliorates the development of EAE caused by injection of myelin oligodendrocyte glycoprotein (MOG)(35-55) in mice. These data renew the focus on the IK channel as a potential target for the development...

  19. Preclinical study evaluating a novel trocar site closure system

    Directory of Open Access Journals (Sweden)

    Walker PA

    2016-04-01

    Full Text Available Peter A Walker,1 Shinil K Shah,1,2 Erik B Wilson11Department of Surgery, University of Texas Medical School at Houston, Houston, TX, USA; 2Michael E DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices, Texas A&M University, College Station, TX, USAIntroduction: Novel trocar closure devices using subperitoneal anchor placement avoid the need for a closed loop suture, and could allow faster trocar site closure with less risk derived from less instrument penetration into the abdominal cavity while decreasing fascial ischemia and tension. We completed a series of animal experiments to compare the Carter-Thomason® suture closure device and neoClose® AnchorGuide device in order to evaluate device safety, efficacy, and ease of utilization.Methods: A porcine model was utilized where 12 mm port sites were closed with either the Carter-Thomason® device or neoClose® AnchorGuide device. Animals were sacrificed at 14 and 56 days after trocar site closure followed by macroscopic and microscopic wound examination. A second group of animals underwent video analysis to evaluate the time required for fascial closure as well as depth of needle passage into the abdomen.Results: All animals survived to the endpoints (14 and 56 days without mortality or trocar site hernia. A trend towards decreased closure times was identified when using the neoClose® device (t=18.5±2.3 seconds compared to closure with the Carter-Thomason® device (t=32.0±8.9 seconds (P=0.153. A significant decrease in the depth of needle penetration was seen with the neoClose® device (t=31.22±1.45 mm compared to closure with the Carter-Thomason device (t=51.0±3.1 mm (P<0.001. Microscopic analysis showed subperitoneal anchor location at 56 days with minimal fibrosis (neoClose® device compared to nearly complete suture degradation with deep intramuscular location (Carter-Thomason device.Conclusion: Novel trocar closure devices could offer decreased deployment

  20. Stomatal guard cells co-opted an ancient ABA-dependent desiccation survival system to regulate stomatal closure.

    Science.gov (United States)

    Lind, Christof; Dreyer, Ingo; López-Sanjurjo, Enrique J; von Meyer, Katharina; Ishizaki, Kimitsune; Kohchi, Takayuki; Lang, Daniel; Zhao, Yang; Kreuzer, Ines; Al-Rasheid, Khaled A S; Ronne, Hans; Reski, Ralf; Zhu, Jian-Kang; Geiger, Dietmar; Hedrich, Rainer

    2015-03-30

    During the transition from water to land, plants had to cope with the loss of water through transpiration, the inevitable result of photosynthetic CO2 fixation on land [1, 2]. Control of transpiration became possible through the development of a new cell type: guard cells, which form stomata. In vascular plants, stomatal regulation is mediated by the stress hormone ABA, which triggers the opening of the SnR kinase OST1-activated anion channel SLAC1 [3, 4]. To understand the evolution of this regulatory circuit, we cloned both ABA-signaling elements, SLAC1 and OST1, from a charophyte alga, a liverwort, and a moss, and functionally analyzed the channel-kinase interactions. We were able to show that the emergence of stomata in the last common ancestor of mosses and vascular plants coincided with the origin of SLAC1-type channels capable of using the ancient ABA drought signaling kinase OST1 for regulation of stomatal closure. PMID:25802151

  1. A note on inventory model for ameliorating items with time dependent second order demand rate

    Directory of Open Access Journals (Sweden)

    Gobinda Chandra Panda

    2013-03-01

    Full Text Available Background: This paper is concerned with the development of ameliorating inventory models. The ameliorating inventory is the inventory of goods whose utility increases over the time by ameliorating activation. Material and Methods: This study is performed according to two areas: one is an economic order quantity (EOQ model for the items whose utility is ameliorating in accordance with Weibull distribution, and the other is a partial selling quantity (PSQ model developed for selling the surplus inventory accumulated by ameliorating activation with linear demand. The aim of this paper was to develop a mathematical model for inventory type concerned in the paper. Numerical examples were presented show the effect of ameliorating rate on inventory polices.  Results and Conclusions:  The inventory model for items with Weibull ameliorating is developed. For the case of small ameliorating rate (less than linear demand rate, EOQ model is developed, and for the case where ameliorating rate is greater than linear demand rate, PSQ model is developed.  .  

  2. Analysis of Mining-induced Valley Closure Movements

    Science.gov (United States)

    Zhang, C.; Mitra, R.; Oh, J.; Hebblewhite, B.

    2016-05-01

    Valley closure movements have been observed for decades in Australia and overseas when underground mining occurred beneath or in close proximity to valleys and other forms of irregular topographies. Valley closure is defined as the inward movements of the valley sides towards the valley centreline. Due to the complexity of the local geology and the interplay between several geological, topographical and mining factors, the underlying mechanisms that actually cause this behaviour are not completely understood. A comprehensive programme of numerical modelling investigations has been carried out to further evaluate and quantify the influence of a number of these mining and geological factors and their inter-relationships. The factors investigated in this paper include longwall positional factors, horizontal stress, panel width, depth of cover and geological structures around the valley. It is found that mining in a series passing beneath the valley dramatically increases valley closure, and mining parallel to valley induces much more closure than other mining orientations. The redistribution of horizontal stress and influence of mining activity have also been recognised as important factors promoting valley closure, and the effect of geological structure around the valley is found to be relatively small. This paper provides further insight into both the valley closure mechanisms and how these mechanisms should be considered in valley closure prediction models.

  3. Potential of carnuba wax in ameliorating brittle fracture during tableting.

    Science.gov (United States)

    Uhumwangho, M U; Okor, R S; Adogah, J T

    2009-01-01

    Carnuba wax (as binder) forms hard tablets even at low compression load attributable to its high plasticity. The aim of the present study is to investigate its potential in ameliorating brittle fracture (i.e., lamination and capping) a problem often encountered during tableting. Granules of paracetamol (test drug) were made by triturating the drug powder with the melted wax or starch mucilage (20%w/v). Resulting granules were separated into different size fractions which were separately compressed into tablets with and without a centre hole (as in- built defect) using different compression loads. The tablets were evaluated for tensile strength and the data used to calculate the brittle fracture index (BFI), using the expression: BFI = 0.5(T/T(0)-1) where T0 and T are the tensile strength of tablets with and without a centre hole respectively. The BFI values were significantly lower (pload further ameliorated the brittle fracture tendency of the tablets. Using granules with the larger particle size (850microm) and applying the lowest unit of load (6 arbitrary unit on the load scale of the tableting machine) the BFI values were 0.03 (carnuba wax tablets) and 0.11 (maize starch tablets). When the conditions were reversed (i.e., a highest load, 8 units and the smallest particle size, 212microm) the BFI values now became 0.17 (carnuba wax tablets) and 0.26 (maize starch tablets). The indication is that the use of large granules and low compression loads to form tablets can further enhance the potential of carnuba wax in ameliorating brittle fracture tendency of tablets during their manufacture. PMID:19168422

  4. Roscovitine ameliorates endotoxin-induced uveitis through neutrophil apoptosis.

    Science.gov (United States)

    Jiang, Zhao-Xin; Qiu, Suo; Lou, Bing-Sheng; Yang, Yao; Wang, Wen-Cong; Lin, Xiao-Feng

    2016-08-01

    Neutrophils have been recognized as critical response cells during the pathogenesis of endotoxin‑induced uveitis (EIU). Apoptosis of neutrophils induced by roscovitine has previously been demonstrated to ameliorate inflammation in several in vivo models. The present study aimed to assess whether roscovitine ameliorates EIU. EIU was induced in female C57BL/6 mice by a single intravitreal injection of lipopolysaccharide (LPS; 250 ng). The mice were divided into three groups as follows: LPS alone, LPS plus vehicle, LPS plus roscovitine (50 mg/kg). The mice were euthanized 12, 24, 48 and 72 h after LPS‑induced uveitis. Accumulation of inflammatory cells in the vitreous body was confirmed by immunohistochemistry, and quantified following hematoxylin and eosin staining. Terminal deoxynucleotidyl transferase dUTP nick‑end labeling was performed to detect of apoptotic cells. The mRNA levels of inflammatory cytokines were analyzed by reverse transcription‑quantitative polymerase chain reaction and the changes in protein levels were analyzed by western blotting. Inflammatory cells accumulated in the vitreous near the optic nerve head and the quantity peaked at 24 h after LPS injection. Immunohistochemistry revealed that the majority of the inflammatory cells were neutrophils. The number of infiltrating cells was similar in the LPS and LPS plus vehicle groups, while there were significantly less in the roscovitine group at 24 h. Apoptosis of neutrophils was observed between 12 and 48 h after roscovitine injection, while no apoptosis was observed in the other groups. The mRNA expression levels of GMCSF, CINC‑1 and ICAM‑1 peaked at 12 h after LPS injection, and decreased to normal levels at 72 h. This trend in mRNA expression was similar in the LPS and LPS plus vehicle groups; however, the expression levels decreased more quickly in the roscovitine group at 24 and 48 h. Following roscovitine administration, upregulated cleaved caspase 3 expression levels

  5. Administration of red ginseng ameliorates memory decline in aged mice

    OpenAIRE

    Lee, Yeonju; Oh, Seikwan

    2015-01-01

    Background It has been known that ginseng can be applied as a potential nutraceutical for memory impairment; however, experiments with animals of old age are few. Methods To determine the memory enhancing effect of red ginseng, C57BL/6 mice (21 mo old) were given experimental diet pellets containing 0.12% red ginseng extract (approximately 200 mg/kg/d) for 3 mo. Young and old mice (4 mo and 21 mo old, respectively) were used as the control group. The effect of red ginseng, which ameliorated m...

  6. Comparison of Outcomes between Early Fascial Closure and Delayed Abdominal Closure in Patients with Open Abdomen: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Yu Chen

    2014-01-01

    Full Text Available Up to the present, the optimal time to close an open abdomen remains controversial. This study was designed to evaluate whether early fascial abdominal closure had advantages over delayed approach for open abdomen populations. Medline, Embase, and Cochrane Library were searched until April 2013. Search terms included “open abdomen,” “abdominal compartment syndrome,” “laparostomy,” “celiotomy,” “abdominal closure,” “primary,” “delayed,” “permanent,” “fascial closure,” and “definitive closure.” Open abdomen was defined as “fail to close abdominal fascia after a laparotomy.” Mortality, complications, and length of stay were compared between early and delayed fascial closure. In total, 3125 patients were included for final analysis, and 1942 (62% patients successfully achieved early fascial closure. Vacuum assisted fascial closure had no impact on pooled fascial closure rate. Compared with delayed abdominal closure, early fascial closure significantly reduced mortality (12.3% versus 24.8%, RR, 0.53, P<0.0001 and complication incidence (RR, 0.68, P<0.0001. The mean interval from open abdomen to definitive closure ranged from 2.2 to 14.6 days in early fascial closure groups, but from 32.5 to 300 days in delayed closure groups. This study confirmed clinical advantages of early fascial closure over delayed approach in treatment of patients with open abdomen.

  7. Connexin hemichannels and cell-cell channels: comparison of properties

    Directory of Open Access Journals (Sweden)

    V.K. Verselis

    2000-04-01

    Full Text Available Connexin46 (Cx46 forms functional hemichannels in the absence of contact by an apposed hemichannel and we have used these hemichannels to study gating and permeation at the single channel level with high time resolution. Using both cell-attached and -excised patch configurations, we find that single Cx46 hemichannels exhibit some properties expected of half of a gap junction channel, as well as novel properties. Cx46 hemichannels have a large unitary conductance (~300 pS and a relatively large pore as inferred from permeability to TEA. Both monovalent cations and anions can permeate, but cations are substantially more permeable. The open channel conductance shows marked inward rectification in symmetric salts. We find that the conductance and permeability properties of Cx46 cell-cell channels can be explained by the series addition of two hemichannels. These data suggest that the pore structures of unapposed hemichannels and cell-cell channels are conserved. Also like cell-cell channels, unapposed Cx46 hemichannels are closed by elevated levels of H+ or Ca2+ ions on the cytoplasmic face. Closure occurs in excised patches indicating that the actions of these agents do not require a soluble cytoplasmic factor. Fast (<0.5 ms application of H+ to either side of the open hemichannel causes an immediate small reduction in unitary conductance followed by complete closure with latencies that are dependent on H+ concentration and side of application; sensitivity is much greater to H+ on the cytoplasmic side. Closure by cytoplasmic H+ does not require that the hemichannel be open. Thus, H+ ions readily permeate Cx46 hemichannels, but at high enough concentration close them by acting at a cytoplasmic site(s that causes a conformational change resulting in complete closure. Extracellular H+ may permeate to act on the cytoplasmic site or act on a lower affinity extracellular site. Thus, the unapposed hemichannel is a valuable tool in addressing fundamental

  8. Closure of a mixed waste landfill: Lessons learned

    International Nuclear Information System (INIS)

    Much experience has been gained during the closure of the Mixed Waste Management Facility (MWMF) at the Savannah River Site (SRS) and many lessons were learned. This knowledge was applied to other closures at SRS yielding decreased costs, schedule enhancement, and increased overall project efficiency. The next major area of experience to be gained at SRS in the field of waste site closures will be in the upkeep, maintenance, and monitoring of clay caps. Further test programs will be required to address these requirements

  9. 183-H Solar Evaporation Basins PostClosure Plan

    International Nuclear Information System (INIS)

    The 183-H Solar Evaporation Basins (183-H) have certified closure under a modified closure option available in the Hanford Facility Dangerous Waste Permit under Condition II.K.3. The following information contains a description of the unit, past closure actions, and postclosure care requirements subject to compliance under the Permit. Corrective actions required for dangerous waste constituents remaining at 183-H will occur in conjunction with Comprehensive Environmental Response, Compensation, and Liability Act remedial actions for the 100-HR-1 Source Operable Unit and the 100-HR-3 Groundwater Operable Unit

  10. Closure for a wall opening in nuclear plants

    International Nuclear Information System (INIS)

    The invention concerns a closure for the radiation shielding closing of a wall opening between two large adjacent cells in nuclear plants. If one of the two large cells is provided with a cell crane, the adjacent large cell is usually made an intervention area, so as to be able to do maintenance on the cell crane in it. The wall opening between the two large cells must be closed during repair work to the cell crane. The closure is therefore arranged so that it can run on horizontal rails. The external profile of the closure fits tightly into the internal profile of the wall opening, or covers the wall opening completely. (orig.)

  11. Acoustic technique for determining timing of velopharyngeal closure in swallowing.

    Science.gov (United States)

    Smith, D; Hamlet, S; Jones, L

    1990-01-01

    A pure tone sound source was introduced at a nostril and monitored by a miniature accelerometer on the throat. During velopharyngeal closure in a swallow, the pure tone component in the accelerometer signal was attenuated. Throat accelerometer recordings were made simultaneously with videofluoroscopy of a modified barium swallow in adults with normal velopharyngeal mechanisms. It was verified that the period of sound attenuation corresponded to the period of velar closure. This noninvasive method of monitoring otherwise silent velopharyngeal closure holds promise for normative studies on swallowing function, as an adjunct method in longitudinal assessment, and as a training aid. PMID:2249490

  12. PRECL: A new method for interferometry imaging from closure phase

    Science.gov (United States)

    Ikeda, Shiro; Tazaki, Fumie; Akiyama, Kazunori; Hada, Kazuhiro; Honma, Mareki

    2016-06-01

    For short-wavelength VLBI observations, it is difficult to measure the phase of the visibility function accurately. The closure phases are reliable measurements under this situation, though it is not sufficient to retrieve all of the phase information. We propose a new method, phase retrieval from closure phase (PRECL). PRECL estimates all the visibility phases only from the closure phases. Combining PRECL with a sparse modeling method we have already proposed, the imaging process of VLBI does not rely on a dirty image or self-calibration. The proposed method is tested numerically and the results are promising.

  13. PRECL: A new method for interferometry imaging from closure phase

    CERN Document Server

    Ikeda, Shiro; Akiyama, Kazunori; Hada, Kazuhiro; Honma, Mareki

    2016-01-01

    For short-wavelength VLBI observations, it is difficult to measure the phase of the visibility function accurately. The closure phases are reliable measurements under this situation, though it is not sufficient to retrieve all of the phase information. We propose a new method, Phase Retrieval from Closure Phase (PRECL). PRECL estimates all the visibility phases only from the closure phases. Combining PRECL with a sparse modeling method we have already proposed, imaging process of VLBI does not rely on dirty image nor self-calibration. The proposed method is tested numerically and the results are promising.

  14. Homology cylinders and the acyclic closure of a free group

    OpenAIRE

    Sakasai, Takuya

    2005-01-01

    We give a Dehn-Nielsen type theorem for the homology cobordism group of homology cylinders by considering its action on the acyclic closure, which was defined by Levine, of a free group. Then we construct an additive invariant of those homology cylinders which act on the acyclic closure trivially. We also describe some tools to study the automorphism group of the acyclic closure of a free group generalizing those for the automorphism group of a free group or the homology cobordism group of ho...

  15. Mobile radio channels

    CERN Document Server

    Pätzold, Matthias

    2011-01-01

    Providing a comprehensive overview of the modelling, analysis and simulation of mobile radio channels, this book gives a detailed understanding of fundamental issues and examines state-of-the-art techniques in mobile radio channel modelling. It analyses several mobile fading channels, including terrestrial and satellite flat-fading channels, various types of wideband channels and advanced MIMO channels, providing a fundamental understanding of the issues currently being investigated in the field. Important classes of narrowband, wideband, and space-time wireless channels are explored in deta

  16. Regulatory review of closure, post-closure and perpetual care funds at the energy solutions, LLC mixed waste facility

    International Nuclear Information System (INIS)

    EnergySolutions, LLC operates its Mixed Waste Facility at Clive, Utah under the provisions of its State-issued Part B Permit. The facility accepts waste that contains both hazardous and radioactive contaminants. Utah is an EPA Agreement State and therefore the Utah Division of Solid and Hazardous Waste (DSHW) is authorized to regulate the hazardous waste operations at the facility. The radioactive portion of the waste is regulated by the Utah Division of Radiation Control. 40 CFR 264.142 outlines the facility requirements for Closure Costs. The owner or operator must have a detailed written estimate of the cost of closing the facility in accordance with the rules. For many years the State of Utah had relied on the facility's estimate of closure costs as the amount that needed to be funded. This amount is reviewed annually and adjusted for inflation and for changes at the facility. In 2004 the agency and the facility requested bids from independent contractors to provide their estimate for closure costs. Three engineering firms bid on the project. The facility funded the project and both the agency and the facility chose one of the firms to provide an independent estimate. The engineering firms met with both parties and toured the facility. They were also provided with the current closure cost line items. Each firm provided an estimated cost for closure of the facility at the point in the facility's active life that would make the closure most expensive. Included with the direct costs were indirect line items such as overhead, profit, mobilization, hazardous working conditions and regulatory oversight. The agency and the facility reviewed the independent estimates and negotiated a final Closure and Post-Closure Cost Estimate for the Mixed Waste Facility. There are several mechanisms allowed under the rules to fund the Closure and Post- Closure Care Funds. EnergySolutions has chosen to fund their costs through the use of an insurance policy. Changing mechanisms from

  17. AMELIORATIVE EFFECTS OF TINOSPORA CORDIFOLIA IN SCIATICA PAIN INDUCED RATS

    Directory of Open Access Journals (Sweden)

    Thaakur Santhrani

    2012-05-01

    Full Text Available The present study was aimed at investigating the ameliorative effect of Tinospora cordifolia in sciatic nerve root Ligation -induced sciatica pain in rats. Adult male albino rats weighing 130-150gm were used for the study, and were divided into seven groups and ligation was performed on left sciatic nerve in group II to group VII. Tail cold-hyperalgesia, motor co-ordination tests, foot deformity, and total calcium levels were estimated to assess the extent of sciatica. Superoxide dismutase (SOD, catalase (CAT, and lipid peroxide (LPO levels were estimated to evaluate the extent of oxidative stress. The alcoholic and aqueous extract of Tinospora cordifolia was administered at a dose of 100 and 200 mg/kg/p.o for 15 days. Tinospora cordifolia attenuated sciatic nerve root Ligation-induced motor in-coordination, foot deformity, tail cold hyperalgesia, reversed ligation-induced alterations in lipid peroxides, total calcium, superoxide dismutase, catalase levels in a dose-dependent manner. Ameliorative effects of Tinospora cordifolia in ligation-induced sciatica may be due to its foot deformity, antioxidant, and calcium attenuating actions.

  18. Simvastatin ameliorates gentamicin-induced renal injury in rats

    Directory of Open Access Journals (Sweden)

    Mosadegh Jabbari

    2011-01-01

    Full Text Available Gentamicin nephrotoxicity is one of the most common causes of acute renal failure. Simvastatin is one of the antioxidative drugs, which has anti-inflammatory and anabolic effects and modulates the immune system. The present study was conducted to assess the effect of simvastatin on ameliorating the gentamicin-induced renal injury in 87 Sprague-Dawley rats, which were allocated randomly to 11 study groups: (A and (B groups with only gentamicin in 2 dosages; (C, (D, and (E gentamicin 50 mg/kg/day and simvastatin with different dosage; (F, (G, and (H gentamicin 80 mg/kg/day and simvastatin with different dosage; (I only simvastatin; (J Injected normal saline; (K control (no gentamicin and no simvastatin group. Our study intervention period for injection of drugs was 12 days. Serum creatinine level and clearance were measured in all groups. At the end of the study, the rats were killed and both kidneys were removed and processed for histopathologic examination using the standard methods. The 50 mg/kg/day dose was utilized because it induces a mild form of renal toxicity, whereas the 80 mg/kg/day dose cause a more severe degree of renal injury. Morphologic examination of specimens from all rats was qualitatively assessed with blindness to treatment groups and proximal tubular profiles that were presented in each file were counted. The results demonstrated amelioration of gentamicin-induced renal toxicity in rats by simvastatin due to its antioxidant drug dose-related effect.

  19. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms.

    Science.gov (United States)

    Nyström, Alexander; Thriene, Kerstin; Mittapalli, Venugopal; Kern, Johannes S; Kiritsi, Dimitra; Dengjel, Jörn; Bruckner-Tuderman, Leena

    2015-09-01

    Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)-a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive. Here, we report an alternative evidence-based approach to ameliorate fibrosis and relieve symptoms in RDEB. Based on the findings that TGF-β activity is elevated in injured RDEB skin, we targeted TGF-β activity with losartan in a preclinical setting. Long-term treatment of RDEB mice efficiently reduced TGF-β signaling in chronically injured forepaws and halted fibrosis and subsequent fusion of the digits. In addition, proteomics analysis of losartan- vs. vehicle-treated RDEB skin uncovered changes in multiple proteins related to tissue inflammation. In line with this, losartan reduced inflammation and diminished TNF-α and IL-6 expression in injured forepaws. Collectively, the data argue that RDEB fibrosis is a consequence of a cascade encompassing tissue damage, TGF-β-mediated inflammation, and matrix remodeling. Inhibition of TGF-β activity limits these unwanted outcomes and thereby substantially ameliorates long-term symptoms. PMID:26194911

  20. Guanfacine ameliorates hypobaric hypoxia induced spatial working memory deficits.

    Science.gov (United States)

    Kauser, H; Sahu, S; Kumar, S; Panjwani, U

    2014-01-17

    Hypobaric hypoxia (HH) observed at high altitude causes mild cognitive impairment specifically affecting attention and working memory. Adrenergic dysregulation and neuronal damage in prefrontal cortex (PFC) has been implicated in hypoxia induced memory deficits. Optimal stimulation of alpha 2A adrenergic receptor in PFC facilitates the spatial working memory (SWM) under the conditions of adrenergic dysregulation. Therefore the present study was designed to test the efficacy of alpha 2A adrenergic agonist, Guanfacine (GFC), to restore HH induced SWM deficits and PFC neuronal damage. The rats were exposed to chronic HH equivalent to 25,000ft for 7days in an animal decompression chamber and received daily treatment of GFC at a dose of 1mg/kg body weight via the intramuscular route during the period of exposure. The cognitive performance was assessed by Delayed Alternation Task (DAT) using T-Maze and PFC neuronal damage was studied by apoptotic and neurodegenerative markers. Percentage of correct choice decreased significantly while perseverative errors showed a significant increase after 7days HH exposure, GFC significantly ameliorated the SWM deficits and perseveration. There was a marked and significant increase in chromatin condensation, DNA fragmentation, neuronal pyknosis and fluoro Jade positive cells in layer II of the medial PFC in hypoxia exposed group, administration of GFC significantly reduced the magnitude of these changes. Modulation of adrenergic mechanisms by GFC may serve as an effective countermeasure in amelioration of prefrontal deficits and neurodegenerative changes during HH. PMID:24184415

  1. Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration

    Directory of Open Access Journals (Sweden)

    R. C. Patra

    2011-01-01

    Full Text Available Oxidative stress has been implicated to play a role, at least in part, in pathogenesis of many disease conditions and toxicities in animals. Overproduction of reactive oxygen species and free radicals beyond the cells intrinsic capacity to neutralize following xenobiotics exposure leads to a state of oxidative stress and resultant damages of lipids, protein, and DNA. Lead and cadmium are the common environmental heavy metal pollutants and have widespread distribution. Both natural and anthropogenic sources including mining, smelting, and other industrial processes are responsible for human and animal exposure. These pollutants, many a times, are copollutants leading to concurrent exposure to living beings and resultant synergistic deleterious health effects. Several mechanisms have been explained for the damaging effects on the body system. Of late, oxidative stress has been implicated in the pathogenesis of the lead- and cadmium-induced pathotoxicity. Several ameliorative measures to counteract the oxidative damage to the body system aftermath or during exposure to these toxicants have been assessed with the use of antioxidants. The present review focuses on mechanism of lead- and cadmium-induced oxidate damages and the ameliorative measures to counteract the oxidative damage and pathotoxicity with the use of supplemented antioxidants for their beneficial effects.

  2. Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment

    Directory of Open Access Journals (Sweden)

    Seikwan Oh

    2011-10-01

    Full Text Available The function and the role phytoceramide (PCER and phytosphingosine (PSO in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuro-protective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o. recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.

  3. Curcumin ameliorates experimental autoimmune myasthenia gravis by diverse immune cells.

    Science.gov (United States)

    Wang, Shan; Li, Heng; Zhang, Min; Yue, Long-Tao; Wang, Cong-Cong; Zhang, Peng; Liu, Ying; Duan, Rui-Sheng

    2016-07-28

    Curcumin is a traditional Asian medicine with diverse immunomodulatory properties used therapeutically in the treatment of many autoimmune diseases. However, the effects of curcumin on myasthenia gravis (MG) remain undefined. Here we investigated the effects and potential mechanisms of curcumin in experimental autoimmune myasthenia gravis (EAMG). Our results demonstrated that curcumin ameliorated the clinical scores of EAMG, suppressed the expression of T cell co-stimulatory molecules (CD80 and CD86) and MHC class II, down-regulated the levels of pro-inflammatory cytokines (IL-17, IFN-γ and TNF-α) and up-regulated the levels of the anti-inflammatory cytokine IL-10, shifted the balance from Th1/Th17 toward Th2/Treg, and increased the numbers of NKR-P1(+) cells (natural killer cell receptor protein 1 positive cells, including NK and NKT cells). Moreover, the administration of curcumin promoted the differentiation of B cells into a subset of B10 cells, increased the anti-R97-166 peptide IgG1 levels and decreased the relative affinity indexes of anti-R97-116 peptide IgG. In summary, curcumin effectively ameliorate EAMG, indicating that curcumin may be a potential candidate therapeutic agent for MG. PMID:27181511

  4. Channel nut tool

    Energy Technology Data Exchange (ETDEWEB)

    Olson, Marvin

    2016-01-12

    A method, system, and apparatus for installing channel nuts includes a shank, a handle formed on a first end of a shank, and an end piece with a threaded shaft configured to receive a channel nut formed on the second end of the shaft. The tool can be used to insert or remove a channel nut in a channel framing system and then removed from the channel nut.

  5. IT Services availability during CERN annual closure

    CERN Multimedia

    2003-01-01

    Mail, Cern Windows (NICE ),  Web services,  LXPLUS, LXBATCH, Automated tape devices, Castor, Backups, software license servers, Sundev, CVS and Print Servers, CDS and Agenda-Maker, EDMS (in collaboration with EST Division), CMS disc servers, Campus Network,  Remedy, Security and VPN services will be available during the CERN annual closure. The physics database cluster, replication location service as well as accdb, cerndb and admsdb are the only databases available, CCDB will be closed for public access. Problems developing on scheduled services should be addressed within about half a day except around  Christmas Eve and Christmas Day ( 24 and 25th December ) and New Year's Eve and New Years Day (31st December and 1st Janauary. All other services will be left running mostly unattended. No interruptions are scheduled but restoration of the service in case of failure cannot be guaranteed. Please note that the Helpdesk will be closed, that no file restores from backups will be possible and damaged tapes wi...

  6. Don’t call it a closure!

    CERN Multimedia

    Rosaria Marraffino

    2015-01-01

    During the Laboratory’s annual closure, some members of the personnel joined their families, others seized the chance to travel the world. The Restaurants were closed, the corridors were dark and the heating was turned off in most of the buildings. However, a lot of people spent the Christmas break working on site and the Bulletin would like to dedicate this first article of the new year to them all!   In the CERN Control Centre (CCC), each shift had two people in position to guarantee regular 24/7 service and to intervene in case of need. Gildas Langlois and Rodolphe Maillet, CCC operators from the Beams Department, spent Christmas Eve there and celebrated it with a cake. “I volunteered to work during the holidays in order to allow colleagues to stay with their families,” says Maillet. On New Year’s Eve, it was Julien Pache and Jean-Michel Nonglaton’s turn to spend the night at work. They had a nice dinner with a CCC-made fondue and some desse...

  7. Nonlinear closures for scale separation in supersonic magnetohydrodynamic turbulence

    CERN Document Server

    Grete, Philipp; Schmidt, Wolfram; Schleicher, Dominik R G; Federrath, Christoph

    2015-01-01

    Turbulence in compressible plasma plays a key role in many areas of astrophysics and engineering. The extreme plasma parameters in these environments, e.g. high Reynolds numbers, supersonic and super-Alfvenic flows, however, make direct numerical simulations computationally intractable even for the simplest treatment -- magnetohydrodynamics (MHD). To overcome this problem one can use subgrid-scale (SGS) closures -- models for the influence of unresolved, subgrid-scales on the resolved ones. In this work we propose and validate a set of constant coefficient closures for the resolved, compressible, ideal MHD equations. The subgrid-scale energies are modeled by Smagorinsky-like equilibrium closures. The turbulent stresses and the electromotive force (EMF) are described by expressions that are nonlinear in terms of large scale velocity and magnetic field gradients. To verify the closures we conduct a priori tests over 137 simulation snapshots from two different codes with varying ratios of thermal to magnetic pre...

  8. Economic evaluation of closure cap barrier materials study

    International Nuclear Information System (INIS)

    Volume II of the Economic Evaluation of the Closure Cap Barrier Materials, Revision I contains detailed cost estimates for closure cap barrier materials. The cost estimates incorporate the life cycle costs for a generic hazardous waste seepage basin closure cap under the RCRA Post Closure Period of thirty years. The economic evaluation assessed six barrier material categories. Each of these categories consists of several composite cover system configurations, which were used to develop individual cost estimates. The information contained in this report is not intended to be used as a cost estimating manual. This information provides the decision makers with the ability to screen barrier materials, cover system configurations, and identify cost-effective materials for further consideration

  9. 300 Area waste acid treatment system closure plan

    International Nuclear Information System (INIS)

    The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOERL-91-28) and a Unit-Specific Portion. The scope of the Unit-Specific Portion includes closure plan documentation submitted for individual, treatment, storage, and/or disposal units undergoing closure, such as the 300 Area Waste Acid Treatment System. Documentation contained in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in the General Information Portion). Whenever appropriate, 300 Area Waste Acid Treatment System documentation makes cross-reference to the General Information Portion, rather than duplicating text. This 300 Area Waste Acid Treatment System Closure Plan (Revision 2) includes a Hanford Facility Dangerous Waste Permit Application, Part A, Form 3. Information provided in this closure plan is current as of April 1999

  10. 300 Area waste acid treatment system closure plan

    Energy Technology Data Exchange (ETDEWEB)

    LUKE, S.N.

    1999-05-17

    The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOERL-91-28) and a Unit-Specific Portion. The scope of the Unit-Specific Portion includes closure plan documentation submitted for individual, treatment, storage, and/or disposal units undergoing closure, such as the 300 Area Waste Acid Treatment System. Documentation contained in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in the General Information Portion). Whenever appropriate, 300 Area Waste Acid Treatment System documentation makes cross-reference to the General Information Portion, rather than duplicating text. This 300 Area Waste Acid Treatment System Closure Plan (Revision 2) includes a Hanford Facility Dangerous Waste Permit Application, Part A, Form 3. Information provided in this closure plan is current as of April 1999.

  11. 300 Area waste acid treatment system closure plan. Revision 1

    International Nuclear Information System (INIS)

    This section provides a description of the Hanford Site, identifies the proposed method of 300 Area Waste Acid Treatment System (WATS) closure, and briefly summarizes the contents of each chapter of this plan

  12. Optical closure of parameterized bio-optical relationships

    Science.gov (United States)

    He, Shuangyan; Fischer, Jürgen; Schaale, Michael; He, Ming-xia

    2014-03-01

    An optical closure study on bio-optical relationships was carried out using radiative transfer model matrix operator method developed by Freie Universität Berlin. As a case study, the optical closure of bio-optical relationships empirically parameterized with in situ data for the East China Sea was examined. Remote-sensing reflectance ( R rs) was computed from the inherent optical properties predicted by these biooptical relationships and compared with published in situ data. It was found that the simulated R rs was overestimated for turbid water. To achieve optical closure, bio-optical relationships for absorption and scattering coefficients for suspended particulate matter were adjusted. Furthermore, the results show that the Fournier and Forand phase functions obtained from the adjusted relationships perform better than the Petzold phase function. Therefore, before bio-optical relationships are used for a local sea area, the optical closure should be examined.

  13. Underground storage tank 253-D1U1 Closure Plan

    Energy Technology Data Exchange (ETDEWEB)

    Mancieri, S.; Giuntoli, N.

    1993-09-01

    This report is a closure plan for a diesel fuel tank at the Lawrence Livermore National Laboratory. Included are maps of the site, work plans, and personnel information regarding training and qualification.

  14. LLNL/YMP Waste Container Fabrication and Closure Project

    International Nuclear Information System (INIS)

    The Department of Energy's Office of Civilian Radioactive Waste Management (OCRWM) Program is studying Yucca Mountain, Nevada as a suitable site for the first US high-level nuclear waste repository. Lawrence Livermore National Laboratory (LLNL) has the responsibility for designing and developing the waste package for the permanent storage of high-level nuclear waste. This report is a summary of the technical activities for the LLNL/YMP Nuclear Waste Disposal Container Fabrication and Closure Development Project. Candidate welding closure processes were identified in the Phase 1 report. This report discusses Phase 2. Phase 2 of this effort involved laboratory studies to determine the optimum fabrication and closure processes. Because of budget limitations, LLNL narrowed the materials for evaluation in Phase 2 from the original six to four: Alloy 825, CDA 715, CDA 102 (or CDA 122) and CDA 952. Phase 2 studies focused on evaluation of candidate material in conjunction with fabrication and closure processes

  15. Requirements for expected performance of closure components in crystalline rock

    International Nuclear Information System (INIS)

    Based on the results and experiences obtained from the tunnel sealing experiments in the Canadian underground research laboratory in crystalline rock under the collaboration with JNC (now JAEA), this report summarizes the requirements for closure components such as backfilling material and hydraulic plug from the viewpoint of expected barrier performance, taking account of key issues on sealing technologies which have been left open after H12 project. The results of the tunnel sealing experiments indicate that the constructability of closure components and low permeability of the hydraulic plug is well performed. Requirements for the closure components and key issues for further study are identified from the viewpoint of barrier performance considering a range of events related to the sealing and taking account of where these are occurred as well as appropriate countermeasure for them. It is also discussed how to apply these preferable closure components to the scale of repository layout, and further technical issues are then identified. (author)

  16. Percutaneous left atrial appendage closure for stroke prevention

    DEFF Research Database (Denmark)

    De Backer, Ole; Loupis, Anastasia M; Ihlemann, Nikolaj;

    2014-01-01

    INTRODUCTION: In atrial fibrillation (AF) patients with an increased stroke risk, oral anticoagulation (OAC) is the standard treatment for stroke prevention. However, this therapy carries a high risk of major bleeding. Percutaneous closure of the left atrial appendage (LAA) is suggested as an...... alternative option for stroke prevention in AF patients with contraindication(s) for OAC treatment. MATERIAL AND METHODS: A total of 42 patients underwent percutaneous LAA closure. In this report, we describe our experience with this procedure. RESULTS: The patients treated were AF patients with a high stroke......-BLED (7.6%/year) for the patient cohort. At echo follow-up, incomplete LAA closure was seen in one case; device thrombosis was not observed. CONCLUSION: Our data confirm that percutaneous LAA closure can be a safe and effective strategy for stroke prevention in AF patients with an increased stroke and...

  17. Economic evaluation of closure cap barrier materials study

    Energy Technology Data Exchange (ETDEWEB)

    Serrato, M.G.; Bhutani, J.S.; Mead, S.M.

    1993-09-01

    Volume II of the Economic Evaluation of the Closure Cap Barrier Materials, Revision I contains detailed cost estimates for closure cap barrier materials. The cost estimates incorporate the life cycle costs for a generic hazardous waste seepage basin closure cap under the RCRA Post Closure Period of thirty years. The economic evaluation assessed six barrier material categories. Each of these categories consists of several composite cover system configurations, which were used to develop individual cost estimates. The information contained in this report is not intended to be used as a cost estimating manual. This information provides the decision makers with the ability to screen barrier materials, cover system configurations, and identify cost-effective materials for further consideration.

  18. Stress analysis of closure bolts for shipping casks

    International Nuclear Information System (INIS)

    This report specifies the requirements and criteria for stress analysis of closure bolts for shipping casks containing nuclear spent fuels or high level radioactive materials. The specification is based on existing information conceming the structural behavior, analysis, and design of bolted joints. The approach taken was to extend the ASME Boiler and Pressure Vessel Code requirements and criteria for bolting analysis of nuclear piping and pressure vessels to include the appropriate design and load characteristics of the shipping cask. The characteristics considered are large, flat, closure lids with metal-to-metal contact within the bolted joint; significant temperature and impact loads; and possible prying and bending effects. Specific formulas and procedures developed apply to the bolt stress analysis of a circular, flat, bolted closure. The report also includes critical load cases and desirable design practices for the bolted closure, an in-depth review of the structural behavior of bolted joints, and a comprehensive bibliography of current information on bolted joints

  19. A closure relation to molecular theory of solvation for macromolecules.

    Science.gov (United States)

    Kobryn, Alexander E; Gusarov, Sergey; Kovalenko, Andriy

    2016-10-12

    We propose a closure to the integral equations of molecular theory of solvation, particularly suitable for polar and charged macromolecules in electrolyte solution. This includes such systems as oligomeric polyelectrolytes at a finite concentration in aqueous and various non-aqueous solutions, as well as drug-like compounds in solution. The new closure by Kobryn, Gusarov, and Kovalenko (KGK closure) imposes the mean spherical approximation (MSA) almost everywhere in the solvation shell but levels out the density distribution function to zero (with the continuity at joint boundaries) inside the repulsive core and in the spatial regions of strong density depletion emerging due to molecular associative interactions. Similarly to MSA, the KGK closure reduces the problem to a linear equation for the direct correlation function which is predefined analytically on most of the solvation shells and has to be determined numerically on a relatively small (three-dimensional) domain of strong depletion, typically within the repulsive core. The KGK closure leads to the solvation free energy in the form of the Gaussian fluctuation (GF) functional. We first test the performance of the KGK closure coupled to the reference interaction site model (RISM) integral equations on the examples of Lennard-Jones liquids, polar and nonpolar molecular solvents, including water, and aqueous solutions of simple ions. The solvation structure, solvation chemical potential, and compressibility obtained from RISM with the KGK closure favorably compare to the results of the hypernetted chain (HNC) and Kovalenko-Hirata (KH) closures, including their combination with the GF solvation free energy. We then use the KGK closure coupled to RISM to obtain the solvation structure and thermodynamics of oligomeric polyelectrolytes and drug-like compounds at a finite concentration in electrolyte solution, for which no convergence is obtained with other closures. For comparison, we calculate their solvation

  20. Design Alternative Evaluation No. 3: Post-Closure Ventilation

    International Nuclear Information System (INIS)

    The objective of this study is to provide input to the Enhanced Design Alternatives (EDA) for License Application Design Selection (LADS). Its purpose is to develop and evaluate conceptual designs for post-closure ventilation alternatives that enhance repository performance. Post-closure ventilation is expected to enhance repository performance by limiting the amount of water contacting the waste packages. Limiting the amount of water contacting the waste packages will reduce corrosion

  1. Techniques and materials for skin closure in caesarean section

    DEFF Research Database (Denmark)

    Mackeen, A Dhanya; Berghella, Vincenzo; Larsen, Mie-Louise

    2012-01-01

    Caesarean section is a common operation with no agreed upon standard regarding certain operative techniques or materials to use. With regard to skin closure, the skin incision can be re-approximated by a subcuticular suture immediately below the skin layer, by an interrupted suture, or by staples....... A great variety of materials and techniques are used for skin closure after caesarean section and there is a need to identify which provide the best outcomes for women....

  2. Splinting with diastema closure as an adjunct to periodontal therapy

    OpenAIRE

    Gandi, Padma; Rajavasireddi, Shravanthi Rajah; Gurram, Sindhura Reddy

    2013-01-01

    A variety of treatment modalities, from removable partial dentures, fixed prosthesis to implant placement can be used for replacement of missing teeth. Anterior diastema closure is one of the most challenging tasks; it is appreciable that restorative approach is the fastest, simplest and most predictable. This case report presents a successfully accomplished closure of diastema in mandibular anterior teeth, and splinting of the adjacent teeth which were grade II mobile. This present treatment...

  3. 303-K Storage Facility: Report on FY98 closure activities

    International Nuclear Information System (INIS)

    This report summarizes and evaluates the decontamination activities, sampling activities, and sample analysis performed in support of the closure of the 303-K Storage Facility. The evaluation is based on the validated data included in the data validation package (98-EAP-346) for the 303-K Storage Facility. The results of this evaluation will be used for assessing contamination for the purpose of closing the 303-K Storage Facility as described in the 303-K Storage Facility Closure Plan, DOE/RL-90-04. The closure strategy for the 303-K Storage Facility is to decontaminate the interior of the north half of the 303-K Building to remove known or suspected dangerous waste contamination, to sample the interior concrete and exterior soils for the constituents of concern, and then to perform data analysis, with an evaluation to determine if the closure activities and data meet the closure criteria. The closure criteria for the 303-K Storage Facility is that the concentrations of constituents of concern are not present above the cleanup levels. Based on the evaluation of the decontamination activities, sampling activities, and sample data, determination has been made that the soils at the 303-K Storage Facility meet the cleanup performance standards (WMH 1997) and can be clean closed. The evaluation determined that the 303-K Building cannot be clean closed without additional closure activities. An additional evaluation will be needed to determine the specific activities required to clean close the 303-K Storage Facility. The radiological contamination at the 303-K Storage Facility is not addressed by the closure strategy

  4. 303-K Storage Facility report on FY98 closure activities

    Energy Technology Data Exchange (ETDEWEB)

    Adler, J.G.

    1998-07-17

    This report summarizes and evaluates the decontamination activities, sampling activities, and sample analysis performed in support of the closure of the 303-K Storage Facility. The evaluation is based on the validated data included in the data validation package (98-EAP-346) for the 303-K Storage Facility. The results of this evaluation will be used for assessing contamination for the purpose of closing the 303-K Storage Facility as described in the 303-K Storage Facility Closure Plan, DOE/RL-90-04. The closure strategy for the 303-K Storage Facility is to decontaminate the interior of the north half of the 303-K Building to remove known or suspected dangerous waste contamination, to sample the interior concrete and exterior soils for the constituents of concern, and then to perform data analysis, with an evaluation to determine if the closure activities and data meet the closure criteria. The closure criteria for the 303-K Storage Facility is that the concentrations of constituents of concern are not present above the cleanup levels. Based on the evaluation of the decontamination activities, sampling activities, and sample data, determination has been made that the soils at the 303-K Storage Facility meet the cleanup performance standards (WMH 1997) and can be clean closed. The evaluation determined that the 303-K Building cannot be clean closed without additional closure activities. An additional evaluation will be needed to determine the specific activities required to clean close the 303-K Storage Facility. The radiological contamination at the 303-K Storage Facility is not addressed by the closure strategy.

  5. Characteristics of Glottic Closure Reflex in a Canine Model

    OpenAIRE

    Kim, Young-Ho; Kang, Ju Wan; Kim, Kwang-Moon

    2009-01-01

    Purpose The most important function of the larynx is airway protection which is provided through a polysynaptic reflex closure triggered by the receptors in the glottic and supraglottic mucosa, evoking the reflex contraction of the laryngeal muscles especially by strong adduction of vocal cords. Based on the hypotheses that central facilitation is essential for this bilateral adductor reflex and that its disturbance can result in weakened laryngeal closure, we designed this study to elucidate...

  6. Percutaneous device closure of persistent ductus venosus presenting with hemoptysis

    Directory of Open Access Journals (Sweden)

    Venkateshwaran Subramanian

    2013-01-01

    Full Text Available An eight-year-old boy was evaluated for unexplained hemoptysis and cyanosis. A contrast echocardiogram was suggestive of pulmonary arteriovenous fistula. Further evaluation revealed persistent ductus venosus (PDV and aortopulmonary collaterals. Both the PDV and aortopulmonary collaterals were closed percutaneously. PDV is amenable for device closure after detailed anatomical evaluation. Prior to closure, it is important to ensure adequate portal vein arborization into the liver and normal portal pressure after test balloon occlusion.

  7. Design Alternative Evaluation No. 3: Post-Closure Ventilation

    Energy Technology Data Exchange (ETDEWEB)

    Logan, R.C.

    1999-06-22

    The objective of this study is to provide input to the Enhanced Design Alternatives (EDA) for License Application Design Selection (LADS). Its purpose is to develop and evaluate conceptual designs for post-closure ventilation alternatives that enhance repository performance. Post-closure ventilation is expected to enhance repository performance by limiting the amount of water contacting the waste packages. Limiting the amount of water contacting the waste packages will reduce corrosion.

  8. The effect of school closure on principal leadership

    OpenAIRE

    Lenarduzzi, Grant Peter

    2010-01-01

    School closures have been the focus of educational research in the past; however, the perceived effect of this critical event on the school leader has been marginally investigated. A principal’s leadership has been proven to be influential in determining the effectiveness of the learning environment. Succession pressure on maintaining effective school leadership is increasing. Understanding the school leader’s experience of living through a closure process will help to sustain and enrich t...

  9. Characterizing Weighted MSO for Trees by Branching Transitive Closure Logics

    OpenAIRE

    Fülöp, Zoltán; Vogler, Heiko

    2012-01-01

    We introduce the branching transitive closure operator on weighted monadic second-order logic formulas where the branching corresponds in a natural way to the branching inherent in trees. For arbitrary commutative semirings, we prove that weighted monadic second order logics on trees is equivalent to the definability by formulas which start with one of the following operators: (i) a branching transitive closure or (ii) an existential second-order quantifier followed by one universal first-ord...

  10. Primary fascial closure with laparoscopic ventral hernia repair: systematic review.

    Science.gov (United States)

    Nguyen, Duyen H; Nguyen, Mylan T; Askenasy, Erik P; Kao, Lillian S; Liang, Mike K

    2014-12-01

    Laparoscopic ventral hernia repair (LVHR) has grown in popularity. Typically, this procedure is performed with a mesh bridge technique that results in high rates of seroma, eventration (bulging), and patient dissatisfaction. In an effort to avoid these complications, there is growing interest in the role of laparoscopic primary fascial closure with intraperitoneal mesh placement. This systematic review evaluated the outcomes of closure of the central defect during LVHR. A literature search of PubMed, Cochrane databases, and Embase was conducted using PRISMA guidelines. MINORS was used to assess the methodologic quality. Primary outcome was hernia recurrence. Secondary outcomes were surgical-site infection, seroma formation, bulging, and patient-centered items (satisfaction, chronic pain, functional status). Eleven studies were identified, eight of which were case series (level 4 data). Three comparative studies examined the difference between closure and nonclosure of the fascial defect during laparoscopic ventral incisional hernia repairs (level 3 and 4 data). These studies suggested that primary fascial closure (n = 138) compared to nonclosure (n = 255) resulted in lower recurrence rates (0-5.7 vs. 4.8-16.7 %) and seroma formation rates (5.6-11.4 vs. 4.3-27.8 %). Follow-up periods for both groups were similar (1-108 months). Only one study evaluated patient function and clinical bulging. It showed better outcomes with primary fascial closure. Closure of the central defect during LVHR resulted in less recurrence, bulging, and seroma than nonclosure. Patients with closure were more satisfied with the results and had better functional status. The quality of the data was poor, however. A randomized controlled trial to evaluate the role of closure of the central defect during LVHR is warranted. PMID:25145817

  11. 18 CFR 2.23 - Use of reserved authority in hydropower licenses to ameliorate cumulative impacts.

    Science.gov (United States)

    2010-04-01

    ... authority in hydropower licenses to ameliorate cumulative impacts. 2.23 Section 2.23 Conservation of Power... § 2.23 Use of reserved authority in hydropower licenses to ameliorate cumulative impacts. The... opportunity for hearing by the licensee and all interested parties. Hydropower licenses also contain...

  12. HERA Mock Observations: Looking for Closure HERA Memorandum Number 13

    CERN Document Server

    Carilli, C L

    2016-01-01

    We investigate the use of closure phase as a method to detect the HI 21cm signal from the neutral IGM during cosmic reionzation. Closure quantities have the unique advantage of being independent of antenna-based calibration terms. We employ realistic, large area sky models from Sims et al. (2016). These include an estimate of the HI 21cm signal generated using 21cm FAST, plus continuum models of both the diffuse Galactic synchrotron emission and the extragalactic point sources. We employ the CASA simulator and adopt the Dillon-Parsons HERA configuration to generate a uv measurement set. We then use AIPS to calculate the closure phases as a function of frequency ('closure spectra'), and python scripts for subsequent analysis. We find that the closure spectra for the HI signal show dramatic structure in frequency, and based on thermal noise alone, the redundant HERA-331 array should detect these fluctuations easily. Comparatively, the frequency structure in the continuum closure spectra is much smoother than th...

  13. The Earliest Ion Channels

    Science.gov (United States)

    Pohorille, A.; Wilson, M. A.; Wei, C.

    2009-12-01

    Supplying protocells with ions required assistance from channels spanning their membrane walls. The earliest channels were most likely short proteins that formed transmembrane helical bundles surrounding a water-filled pore. These simple aggregates were capable of transporting ions with efficiencies comparable to those of complex, contemporary ion channels. Channels with wide pores exhibited little ion selectivity but also imposed only modest constraints on amino acid sequences of channel-forming proteins. Channels with small pores could have been selective but also might have required a more precisely defined sequence of amino acids. In contrast to modern channels, their protocellular ancestors had only limited capabilities to regulate ion flux. It is postulated that subsequent evolution of ion channels progressed primarily to acquire precise regulation, and not high efficiency or selectivity. It is further proposed that channels and the surrounding membranes co-evolved.

  14. Anthropogenic changes to the tidal channel network, sediment rerouting, and social implications in southwest Bangladesh

    Science.gov (United States)

    Wilson, C.; Goodbred, S. L., Jr.; Sams, S.; Small, C.

    2015-12-01

    The tidal channel network in southwest Bangladesh has been undergoing major adjustment in response to anthropogenic modification over the past few decades. Densely inhabited, agricultural islands that have been embanked to protect against inundation by tides, river flooding, and storm surges (i.e., polders) preclude tidal exchange and sedimentation. Studies reveal this results in elevation deficits relative to mean high water, endangering local communities when embankment failures occur (e.g., during storms, lateral channel erosion). In addition, many studies suggest that the decrease in tidal prism and associated change in hydrodynamics from poldering causes shoaling in remaining tidal channels, which can cause a disruption in transportation. The widespread closure and conversion of tidal channel areas to profitable shrimp aquaculture is also prevalent in this region. In this study, we quantify the direct closure of tidal channels due to poldering and shrimp aquaculture using historical Landsat and Google Earth imagery, and analyze the morphologic adjustment of the tidal channel network due to these perturbations. In the natural Sundarbans mangrove forest, the tidal channel network has remained relatively constant since the 1970s. In contrast, construction of polders removed >1000 km of primary tidal creeks and >90 km2 has been reclaimed outside of polders through infilling and closure of formerly-active, higher order conduit channels now used for shrimp aquaculture. Field validation confirm tidal restriction by large sluice gates is prevalent, favoring local channel siltation at rates up to 20cm/yr. With the impoundment of primary creeks and closure of 30-60% of conduit channels in the study area, an estimated 1,400 x 106 m3 of water has been removed from the tidal prism and potentially redirected within remaining channels. This has significant implications for tidal amplification in this region. Further, we estimate that 12.3 x 106 MT of sediment annually

  15. Causing Communication Closure: Safe Program Composition with Reliable Non-FIFO Channels

    CERN Document Server

    Engelhardt, Kai

    2009-01-01

    A semantic framework for analyzing safe composition of distributed programs is presented. Its applicability is illustrated by a study of program composition when communication is reliable but not necessarily FIFO\\@. In this model, special care must be taken to ensure that messages do not accidentally overtake one another in the composed program. We show that barriers do not exist in this model. Indeed, no program that sends or receives messages can automatically be composed with arbitrary programs without jeopardizing their intended behavior. Safety of composition becomes context-sensitive and new tools are needed for ensuring it. A notion of \\emph{sealing} is defined, where if a program $P$ is immediately followed by a program $Q$ that seals $P$ then $P$ will be communication-closed--it will execute as if it runs in isolation. The investigation of sealing in this model reveals a novel connection between Lamport causality and safe composition. A characterization of sealable programs is given, as well as effic...

  16. Gramicidin Channels: Versatile Tools

    Science.gov (United States)

    Andersen, Olaf S.; Koeppe, Roger E., II; Roux, Benoît

    Gramicidin channels are miniproteins in which two tryptophan-rich subunits associate by means of transbilayer dimerization to form the conducting channels. That is, in contrast to other ion channels, gramicidin channels do not open and close; they appear and disappear. Each subunit in the bilayer-spanning channel is tied to the bilayer/solution interface through hydrogen bonds that involve the indole NH groups as donors andwater or the phospholipid backbone as acceptors. The channel's permeability characteristics are well-defined: gramicidin channels are selective for monovalent cations, with no measurable permeability to anions or polyvalent cations; ions and water move through a pore whose wall is formed by the peptide backbone; and the single-channel conductance and cation selectivity vary when the amino acid sequence is varied, even though the permeating ions make no contact with the amino acid side chains. Given the plethora of available experimental information—for not only the wild-type channels but also for channels formed by amino acid-substituted gramicidin analogues—gramicidin channels continue to provide important insights into the microphysics of ion permeation through bilayer-spanning channels. For similar reasons, gramicidin channels constitute a system of choice for evaluating computational strategies for obtaining mechanistic insights into ion permeation through the more complex channels formed by integral membrane proteins.

  17. CLOSURE REPORT FOR CORRECTIVE ACTION UNIT 528: POLYCHLORINATED BIPHENYLS CONTAMINATION NEVADA TEST SITE, NEVADA

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA

    2006-09-01

    This Closure Report (CR) describes the closure activities performed at CAU 528, Polychlorinated Biphenyls Contamination, as presented in the Nevada Division of Environmental Protection (NDEP)-approved Corrective Action Plan (CAP) (US. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSAINSO], 2005). The approved closure alternative was closure in place with administrative controls. This CR provides a summary of the completed closure activities, documentation of waste disposal, and analytical data to confirm that the remediation goals were met.

  18. Multi-Channel Retailing

    Directory of Open Access Journals (Sweden)

    Dirk Morschett, Dr.,

    2005-01-01

    Full Text Available Multi-channel retailing entails the parallel use by retailing enterprises of several sales channels. The results of an online buyer survey which has been conducted to investigate the impact of multi-channel retailing (i.e. the use of several retail channels by one retail company on consumer behaviour show that the frequently expressed concern that the application of multi-channel systems in retailing would be associated with cannibalization effects, has proven unfounded. Indeed, the appropriate degree of similarity, consistency, integration and agreement achieves the exact opposite. Different channels create different advantages for consumers. Therefore the total benefit an enterprise which has a multi-channel system can offer to its consumers is larger, the greater the number of available channels. The use of multi-channel systems is associated with additional purchases in the different channels. Such systems are thus superior to those offering only one sales channel to their customers. Furthermore, multi-channel systems with integrated channels are superior to those in which the channels are essentially autonomous and independent of one another. In integrated systems, consumers can achieve synergy effects in the use of sales-channel systems. Accordingly, when appropriately formulated, multi-channel systems in retailing impact positively on consumers. They use the channels more frequently, buy more from them and there is a positive customer-loyalty impact. Multi-channel systems are strategic options for achieving customer loyalty, exploiting customer potential and for winning new customers. They are thus well suited for approaching differing and varied target groups.

  19. Closure versus non-closure of the peritoneum at caesarean section: short- and long-term outcomes

    OpenAIRE

    Bamigboye, Anthony A; Hofmeyr, G Justus

    2014-01-01

    Background Caesarean section is a very common surgical procedure worldwide. Suturing the peritoneal layers at caesarean section may or may not confer benefit, hence the need to evaluate whether this step should be omitted or routinely performed. Objectives The objective of this review was to assess the effects of non-closure as an alternative to closure of the peritoneum at caesarean section on intraoperative and immediate- and long-term postoperative outcomes. Search methods We searched the ...

  20. 216-B-3 expansion ponds closure plan

    International Nuclear Information System (INIS)

    This document describes the activities for clean closure under the Resource Conservation and Recovery Act of 1976 (RCRA) of the 216-B-3 Expansion Ponds. The 216-B-3 Expansion Ponds are operated by the US Department of Energy, Richland Operations Office (DOE-RL) and co-operated by Westinghouse Hanford Company (Westinghouse Hanford). The 216-B-3 Expansion Ponds consists of a series of three earthen, unlined, interconnected ponds that receive waste water from various 200 East Area operating facilities. The 3A, 3B, and 3C ponds are referred to as Expansion Ponds because they expanded the capability of the B Pond System. Waste water (primarily cooling water, steam condensate, and sanitary water) from various 200 East Area facilities is discharged to the Bypass pipe (Project X-009). Water discharged to the Bypass pipe flows directly into the 216-B-3C Pond. The ponds were operated in a cascade mode, where the Main Pond overflowed into the 3A Pond and the 3A Pond overflowed into the 3C Pond. The 3B Pond has not received waste water since May 1985; however, when in operation, the 3B Pond received overflow from the 3A Pond. In the past, waste water discharges to the Expansion Ponds had the potential to have contained mixed waste (radioactive waste and dangerous waste). The radioactive portion of mixed waste has been interpreted by the US Department of Energy (DOE) to be regulated under the Atomic Energy Act of 1954; the dangerous waste portion of mixed waste is regulated under RCRA

  1. 216-B-3 expansion ponds closure plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    This document describes the activities for clean closure under the Resource Conservation and Recovery Act of 1976 (RCRA) of the 216-B-3 Expansion Ponds. The 216-B-3 Expansion Ponds are operated by the US Department of Energy, Richland Operations Office (DOE-RL) and co-operated by Westinghouse Hanford Company (Westinghouse Hanford). The 216-B-3 Expansion Ponds consists of a series of three earthen, unlined, interconnected ponds that receive waste water from various 200 East Area operating facilities. The 3A, 3B, and 3C ponds are referred to as Expansion Ponds because they expanded the capability of the B Pond System. Waste water (primarily cooling water, steam condensate, and sanitary water) from various 200 East Area facilities is discharged to the Bypass pipe (Project X-009). Water discharged to the Bypass pipe flows directly into the 216-B-3C Pond. The ponds were operated in a cascade mode, where the Main Pond overflowed into the 3A Pond and the 3A Pond overflowed into the 3C Pond. The 3B Pond has not received waste water since May 1985; however, when in operation, the 3B Pond received overflow from the 3A Pond. In the past, waste water discharges to the Expansion Ponds had the potential to have contained mixed waste (radioactive waste and dangerous waste). The radioactive portion of mixed waste has been interpreted by the US Department of Energy (DOE) to be regulated under the Atomic Energy Act of 1954; the dangerous waste portion of mixed waste is regulated under RCRA.

  2. BP refinery closure raises chemical feed issues

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-20

    BP chemicals has reaffirmed its plans to carry on chemicals production at Lima, OH, even though British Petroleum has decided to close the 160,000-bbl/day refinery there in two years. The closure will cut off some streams for chemicals production and marketing. {open_quotes}There will be some things to sort out,{close_quotes} the company says, {open_quotes}but we feel they`re manageable issues.{close_quotes} As with many refineries shut down in the past few years in the US, the site will continue to be operated as a terminal and blending facility. The key chemical plant is a 400-million lbs/year acrylonitrile unit, which uses 200 million lbs/year of propylene from the refinery. BP is the top acrylo producer in North America and its expanding its Green Lake, TX plant from 700 million lbs/year to more than 900 million lbs/year by adding a third reactor; the unit is to be onstream by the end of the year. BP says is will be able to find merchant propylene, if necessary, but will be working on {open_quotes}creative{close_quotes} ways of keeping the propylene splitter on-site operating, it says. BP also produces nitrogen, catalysts, and polymers at its site adjacent to the refinery--all of which will stay in operation. Merchant benzene production of 115 million gal/year and captive toluene production of 110 million gal/year will end with the refinery closing.

  3. Fracture mechanics analyses of partial crack closure in shell structures

    Science.gov (United States)

    Zhao, Jun

    2007-12-01

    This thesis presents the theoretical and finite element analyses of crack-face closure behavior in shells and its effect on the stress intensity factor under a bending load condition. Various shell geometries, such as spherical shell, cylindrical shell containing an axial crack, cylindrical shell containing a circumferential crack and shell with double curvatures, are all studied. In addition, the influence of material orthotropy on the crack closure effect in shells is also considered. The theoretical formulation is developed based on the shallow shell theory of Delale and Erdogan, incorporating the effect of crack-face closure at the compressive edges. The line-contact assumption, simulating the crack-face closure at the compressive edges, is employed so that the contact force at the closure edges is introduced, which can be translated to the mid-plane of the shell, accompanied by an additional distributed bending moment. The unknown contact force is computed by solving a mixed-boundary value problem iteratively, that is, along the crack length, either the normal displacement of the crack face at the compressive edges is equal to zero or the contact pressure is equal to zero. It is found that due to the curvature effects crack closure may not always occur on the entire length of the crack, depending on the direction of the bending load and the geometry of the shell. The crack-face closure influences significantly the magnitude of the stress intensity factors; it increases the membrane component but decreases the bending component. The maximum stress intensity factor is reduced by the crack-face closure. The significant influence of geometry and material orthotropy on rack closure behavior in shells is also predicted based on the analytical solutions. Three-dimensional FEA is performed to validate the theoretical solutions. It demonstrates that the crack face closure occurs actually over an area, not on a line, but the theoretical solutions of the stress intensity

  4. Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: A mechanistic study

    OpenAIRE

    Proks, Peter; de Wet, Heidi; Ashcroft, Frances M

    2014-01-01

    Sulfonylureas, which stimulate insulin secretion from pancreatic β-cells, are widely used to treat both type 2 diabetes and neonatal diabetes. These drugs mediate their effects by binding to the sulfonylurea receptor subunit (SUR) of the ATP-sensitive K+ (KATP) channel and inducing channel closure. The mechanism of channel inhibition is unusually complex. First, sulfonylureas act as partial antagonists of channel activity, and second, their effect is modulated by MgADP. We analyzed the molecu...

  5. Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats

    Directory of Open Access Journals (Sweden)

    Hui-Ya Ho

    2011-01-01

    Full Text Available Flemingia macrophylla (Leguminosae, a native plant of Taiwan, is used as folk medicine. An in vitro study showed that a 75% ethanolic extract of F. macrophylla (FME inhibited osteoclast differentiation of cultured rat bone marrow cells, and the active component, lespedezaflavanone A (LDF-A, was isolated. It was found that oral administration of FME for 13 weeks suppressed bone loss in ovariectomized rats, an experimental model of osteoporosis. In addition, FME decreased urinary deoxypyridinoline concentrations but did not inhibit serum alkaline phosphatase activities, indicating that it ameliorated bone loss via inhibition of bone resorption. These results suggest that FME may represent a useful remedy for the treatment of bone resorption diseases, such as osteoporosis. In addition, LDF-A could be used as a marker compound to control the quality of FME.

  6. Biochar Ameliorate Drought and Salt Stress in Plants

    DEFF Research Database (Denmark)

    Saleem Akhtar, Saqib

    due to its high adsorption capacity; decreasing osmotic stress by enhancing soil moisture content; and releasing mineral nutrients (particularly K+, Ca++, Mg++) into the soil solution - Growth, physiology and yield of plants were positively affected by biochar due to its ability to increase soil...... plant with halophytic plant growth promoting bacteria) approaches. The results showed that: - Biochar mitigated drought stress in plants by enhancing soil moisture availability due to its high porosity and large surface area - Biochar ameliorated salinity stress in plant by a high transient Na+ binding...... moisture content, improve nutrient acquisition and reduce Na+ uptake under drought and salinity stress, respectively - Biochar had long-term positive residual effect on plant growth and performance under salinity stress - Positive responses of biochar on plants could be further enhanced by adopting...

  7. Single-shell tank closure work plan. Revision A

    International Nuclear Information System (INIS)

    In January 1994, the Hanford Federal Facility Agreement and Conset Order (Tri-Party Agreement) was amended to reflect a revised strategy for remediation of radioactive waste in underground storage tanks. These amendments include milestones for closure of the single-shell tank (SST) operable units, to be initiated by March 2012 and completed by September 2024. This SST-CWP has been prepared to address the principal topical areas identified in Tri-Party Agreement Milestone M-45-06 (i.e., regulatory pathway, operable unit characterization, waste retrieval, technology development, and a strategy for achieving closure). Chapter 2.0 of this SST-CWP provides a brief description of the environmental setting, SST System, the origin and characteristics of SST waste, and ancillary equipment that will be remediated as part of SST operable unit closure. Appendix 2A provides a description of the hydrogeology of the Hanford Site, including information on the unsaturated sediments (vadose zone) beneath the 200 Areas Plateau. Chapter 3.0 provides a discussion of the laws and regulations applicable to closure of the SST farm operable units. Chapter 4.0 provides a summary description of the ongoing characterization activities that best align with the proposed regulatory pathway for closure. Chapter 5.0 describes aspects of the SST waste retrieval program, including retrieval strategy, technology, and sequence, potential tank leakage during retrieval, and considerations of deployment of subsurface barriers. Chapter 6.0 outlines a proposed strategy for closure. Chapter 7.0 provides a summary of the programs underway or planned to develop technologies to support closure. Ca. 325 refs

  8. Single-shell tank closure work plan. Revision A

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    In January 1994, the Hanford Federal Facility Agreement and Conset Order (Tri-Party Agreement) was amended to reflect a revised strategy for remediation of radioactive waste in underground storage tanks. These amendments include milestones for closure of the single-shell tank (SST) operable units, to be initiated by March 2012 and completed by September 2024. This SST-CWP has been prepared to address the principal topical areas identified in Tri-Party Agreement Milestone M-45-06 (i.e., regulatory pathway, operable unit characterization, waste retrieval, technology development, and a strategy for achieving closure). Chapter 2.0 of this SST-CWP provides a brief description of the environmental setting, SST System, the origin and characteristics of SST waste, and ancillary equipment that will be remediated as part of SST operable unit closure. Appendix 2A provides a description of the hydrogeology of the Hanford Site, including information on the unsaturated sediments (vadose zone) beneath the 200 Areas Plateau. Chapter 3.0 provides a discussion of the laws and regulations applicable to closure of the SST farm operable units. Chapter 4.0 provides a summary description of the ongoing characterization activities that best align with the proposed regulatory pathway for closure. Chapter 5.0 describes aspects of the SST waste retrieval program, including retrieval strategy, technology, and sequence, potential tank leakage during retrieval, and considerations of deployment of subsurface barriers. Chapter 6.0 outlines a proposed strategy for closure. Chapter 7.0 provides a summary of the programs underway or planned to develop technologies to support closure. Ca. 325 refs.

  9. Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury

    Science.gov (United States)

    Lempiäinen, Juha; Finckenberg, Piet; Mervaala, Elina E; Storvik, Markus; Kaivola, Juha; Lindstedt, Ken; Levijoki, Jouko; Mervaala, Eero M

    2014-01-01

    Kidney ischemia-reperfusion (I/R) injury is a common cause of acute kidney injury. We tested whether dexmedetomidine (Dex), an alpha2 adrenoceptor (α2-AR) agonist, protects against kidney I/R injury. Sprague–Dawley rats were divided into four groups: (1) Sham-operated group; (2) I/R group (40 min ischemia followed by 24 h reperfusion); (3) I/R group + Dex (1 μg/kg i.v. 60 min before the surgery), (4) I/R group + Dex (10 μg/kg). The effects of Dex postconditiong (Dex 1 or 10 μg/kg i.v. after reperfusion) as well as the effects of peripheral α2-AR agonism with fadolmidine were also examined. Hemodynamic effects were monitored, renal function measured, and acute tubular damage along with monocyte/macrophage infiltration scored. Kidney protein kinase B, toll like receptor 4, light chain 3B, p38 mitogen-activated protein kinase (p38 MAPK), sirtuin 1, adenosine monophosphate kinase (AMPK), and endothelial nitric oxide synthase (eNOS) expressions were measured, and kidney transciptome profiles analyzed. Dex preconditioning, but not postconditioning, attenuated I/R injury-induced renal dysfunction, acute tubular necrosis and inflammatory response. Neither pre- nor postconditioning with fadolmidine protected kidneys. Dex decreased blood pressure more than fadolmidine, ameliorated I/R-induced impairment of autophagy and increased renal p38 and eNOS expressions. Dex downregulated 245 and upregulated 61 genes representing 17 enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, in particular, integrin pathway and CD44. Ingenuity analysis revealed inhibition of Rac and nuclear factor (erythroid-derived 2)-like 2 pathways, whereas aryl hydrocarbon receptor (AHR) pathway was activated. Dex preconditioning ameliorates kidney I/R injury and inflammatory response, at least in part, through p38-CD44-pathway and possibly also through ischemic preconditioning. PMID:25505591

  10. Evaluation of water treatment sludge for ameliorating acid mine waste.

    Science.gov (United States)

    Van Rensburg, L; Morgenthal, T L

    2003-01-01

    This study investigated the liming effect of water treatment sludge on acid mine spoils. The study was conducted with sludge from a water purification plant along the Vaal River catchments in South Africa. The optimum application rate for liming acid spoils and the speed and depth with which the sludge reacted with the mine waste were investigated. Chemical analysis indicated that the sludge is suitable as a liming agent because of its alkaline pH (8.08), high bicarbonate concentration (183.03 mg L(-1)), and low salinity (electrical conductivity = 76 mS m(-1)). The high cation exchange capacity of 15.47 cmol(c) kg(-1) and elevated nitrate concentration (73.16 mg L(-1)) also increase its value as an ameliorative material. The soluble concentrations for manganese, aluminum, lead, and selenium were high at a pH of 5 although only selenium (0.83 mg L(-1)) warranted some concern. According to experimental results, the application of 10 Mg ha(-1) of sludge to acid gold tailings increased the leach water pH from 4.5 to more than 7.5 and also increased the medium pH from 2.4 to 7.5. The addition of sludge further reduced the solubility of iron, manganese, copper, and zinc in the ameliorated gold tailings, but increased the electrical conductivity. The liming tempo was highest in the coal discard profile that had a coarse particle size distribution and took the longest to move through the gold tailings that had a fine particle size distribution. Results from this study indicate that the water treatment sludge investigated is suitable as a liming agent for rehabilitation of acid mine waste. PMID:14535306

  11. Calcium channel blocker overdose

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/002580.htm Calcium channel blocker overdose To use the sharing features on this page, please enable JavaScript. Calcium channel blockers are a type of medicine used ...

  12. LARGE EDDY SIMULATION OF PULSATING TURBULENT OPEN CHANNEL FLOW

    Institute of Scientific and Technical Information of China (English)

    ZOU Li-yong; LIU Nan-sheng; LU Xi-yun

    2004-01-01

    Pulsating turbulent open channel flow has been investigated by the use of Large Eddy Simulation (LES) technique coupled with dynamic Sub-Grid-Scale (SGS) model for turbulent SGS stress to closure the governing equations. Three-dimensional filtered Navier-Stokes equations are numerically solved by a fractional-step method. The objective of this study is to deal with the behavior of the pulsating turbulent open channel flow and to examine the reliability of the LES approach for predicting the pulsating turbulent flow. In this study, the Reynolds number (Reτ ) is chosen as 180 based on the friction velocity and the channel depth. The frequency of the driving pressure gradient for the pulsating turbulent flow ranges low, medium and high value. Statistical turbulence quantities as well as the flow structures are analyzed.

  13. Dynamic channel allocation

    OpenAIRE

    Kaminsky, Andrew D.

    2003-01-01

    Approved for public release; distribution in unlimited. Dynamic Channel Allocation (DCA) offers the possibility of capturing unused channel capacity by allocating unused resources between competing network nodes. This can reduce or possibly eliminate channels sitting idle while information awaits transmission. This holds potential for increasing throughput on bandwidth constrained networks. The purpose of this thesis is to examine the techniques used to allocate channels on demand and acc...

  14. KV7 potassium channels

    DEFF Research Database (Denmark)

    Stott, Jennifer B; Jepps, Thomas Andrew; Greenwood, Iain A

    2014-01-01

    Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been...

  15. Quantum Channels With Memory

    International Nuclear Information System (INIS)

    Quantum memory channels represent a very general, yet simple and comprehensible model for causal processes. As such they have attracted considerable research interest, mostly aimed on their transfer capabilities and structure properties. Most notably it was shown that memory channels can be implemented via physically naturally motivated collision models. We also define the concept of repeatable channels and show that only unital channels can be implemented repeat ably with pure memory channels. In the special case of qubit channels we also show that every unital qubit channel has a repeatable implementation. We also briefly explore the possibilities of stroboscopical simulation of channels and show that all random unitary channels can be stroboscopically simulated. Particularly in qubit case, all indivisible qubit channels are also random unitary, hence for qubit all indivisible channels can be stroboscopically simulated. Memory channels also naturally capture the framework of correlated experiments. We develop methods to gather and interpret data obtained in such setting and in detail examine the two qubit case. We also show that for control unitary interactions the measured data will never contradict a simple unitary evolution. Thus no memory effects can be spotted then. (author)

  16. Quantum Multiple Access Channel

    Institute of Scientific and Technical Information of China (English)

    侯广; 黄民信; 张永德

    2002-01-01

    We consider the transmission of classical information over a quantum channel by many senders, which is a generalization of the two-sender case. The channel capacity region is shown to be a convex hull bound by the yon Neumann entropy and the conditional yon Neumann entropies. The result allows a reasonable distribution of channel capacity over the senders.

  17. Desynched channels on IRCnet

    CERN Document Server

    Hansen, Michael

    2008-01-01

    In this paper we describe what a desynchronised channel on IRC is. We give procedures on how to create such a channel and how to remove desynchronisation. We explain which types of desynchronisation there are, what properties desynchronised channels have, and which properties can be exploited.

  18. Baroclinic Channel Model in Fluid Dynamics

    Directory of Open Access Journals (Sweden)

    Kharatti Lal

    2016-02-01

    Full Text Available A complex flow structure is studied using a 2-dimentional baroclinic channel model Unsteady Navier - stokes equation coupled with equation of thermal energy ,salinity and the equation of state are implemented .System closure is achieved through a modified Prandtl, s mixing length formulation of turbulence dissipation The model is applied in a region where the fluid flow is effected by various forcing equation .In this case ,flow is estuarine region affected by diurnal tide and the fresh water inflow in to the estuary and a submerged structure is considered giving possible insight in to stress effects on submerged structure .the result show that in the time evolution of the vertical velocity along downstream edge changes sign from negative to positive .as the dike length increases the primary cell splits and flow becomes turbulent du e to the non-linear effect caused by the dike .these are found to agree favourably with result published in the open literature.

  19. Channel Shallowing as Mitigation of Coastal Flooding

    Directory of Open Access Journals (Sweden)

    Philip M. Orton

    2015-07-01

    Full Text Available Here, we demonstrate that reductions in the depth of inlets or estuary channels can be used to reduce or prevent coastal flooding. A validated hydrodynamic model of Jamaica Bay, New York City (NYC, is used to test nature-based adaptation measures in ameliorating flooding for NYC's two largest historical coastal flood events. In addition to control runs with modern bathymetry, three altered landscape scenarios are tested: (1 increasing the area of wetlands to their 1879 footprint and bathymetry, but leaving deep shipping channels unaltered; (2 shallowing all areas deeper than 2 m in the bay to be 2 m below Mean Low Water; (3 shallowing only the narrowest part of the inlet to the bay. These three scenarios are deliberately extreme and designed to evaluate the leverage each approach exerts on water levels. They result in peak water level reductions of 0.3%, 15%, and 6.8% for Hurricane Sandy, and 2.4%, 46% and 30% for the Category-3 hurricane of 1821, respectively (bay-wide averages. These results suggest that shallowing can provide greater flood protection than wetland restoration, and it is particularly effective at reducing "fast-pulse" storm surges that rise and fall quickly over several hours, like that of the 1821 storm. Nonetheless, the goal of flood mitigation must be weighed against economic, navigation, and ecological needs, and practical concerns such as the availability of sediment.

  20. Decontamination and inspection plan for phase 2 closure of the 300 Area waste acid treatment system

    International Nuclear Information System (INIS)

    This decontamination and inspection plan (DIP) describes decontamination and verification activities in support of Phase 2 closure of the 300 Area Waste Acid Treatment System (WATS). Phase 2, the second phase of three proposed phases of closure for WATS, provides for closure of all WATS portions of the 334-A Building and some, but not all, WATS portions of the 333 and 303-F Buildings. Closure of the entire unit will not occur until all three closure phases have been completed. The DIP also describes the designation and management-process for waste and debris generated during Phase 2 closure activities. Information regarding the decontamination and verification methods for Phase 1 closure can be found in Decontamination and Inspection Plan, for Phase 1 closure of the 300 Area Waste Acid Treatment System, 21 WHC-SD-ENV-AP-001. Information regarding Phase 3 closure will be provided in later documents

  1. Tracheoesophageal puncture site closure with sternocleidomastoid musculocutaneous transposition flap

    Directory of Open Access Journals (Sweden)

    Dushyant Jaiswal

    2015-01-01

    Full Text Available Introduction: Tracheoesophageal voice prosthesis is highly effective in providing speech after total laryngectomy. Although it is a safe method, in certain cases dilatation or leakage occurs around the prosthesis that needs closure of tracheoesophageal fistula. Both non-surgical and surgical methods for closure have been described. Surgical methods are used when non-surgical methods fail. We present the use of the sternocleidomastoid musculocutaneous (SCMMC transposition flap for the closure of tracheoesophageal fistula. Materials and Methods: An incision is made at the mucocutaneous junction circumferentially around the tracheostoma. Tracheoesophageal space is dissected down to and beyond the fistula. The tracheoesophageal tract is divided. The oesophageal mucosa is closed with simple sutures. Then SCMMC transposition flap is raised and transposed to cover sutured oesophagus and the defect between the oesophagus and the trachea. Results: This study was done prospectively over a period of 1 year from June 2012 to May 2013. This technique was used in patients with pliable neck skin. In nine patients, this procedure was done (inferior based flap in nine cases and it was successful in eight patients. In one case, there was dehiscence at the leading edge of flap with oesophageal dehiscence, which required a second procedure. In two cases, there was marginal necrosis of flap, which healed without any intervention. Nine patients in this series were post-radiation. Conclusion: This method of closure is simple and effective for patients with pliable neck skin, who require permanent closure of the tracheoesophageal fistula.

  2. Citalopram associated with acute angle-closure glaucoma: case report

    Directory of Open Access Journals (Sweden)

    Hassan Sabit

    2005-10-01

    Full Text Available Abstract Background Acute angle-closure glaucoma is a rare complication in patients receiving anti-depressant treatment. In the following case, we report the development of acute angle closure glaucoma in a patient who overdosed on Citalopram, an antidepressant, and discuss the possible etiological mechanisms for the condition. Case presentation We report a 54 year old, Caucasian lady, with depression and alcohol dependence syndrome, who developed acute angle-closure glaucoma after an overdose of Citalopram, along with alcohol. She was treated with medications and had bilateral Yag laser iridotomies to correct the glaucoma and has made complete recovery. In this case, the underlying cause for glaucoma appears to be related to the ingestion of Citalopram. Conclusion The patho-physiological basis for acute angle closure glaucoma in relation to antidepressant medications remains unclear. The authors suggest Citalopram may have a direct action on the Iris or Ciliary body muscle through serotonergic or anti-cholinergic mechanisms or both. This case highlights the importance of the awareness of the underlying risks, which may predispose an individual to develop acute angle-closure glaucoma, and reminds the clinicians the significance of history taking and examination of the eye before and after starting anti-depressants. This area needs to be further researched.

  3. Evaluation of transcatheter closure for pulmonary arteriovenous malformation

    International Nuclear Information System (INIS)

    Objective: To evaluate the effect of transcatheter closure for pulmonary arteriovenous malformation (PAVM). Methods: 16 consecutive cases of PAVM underwent transcatheter closure of transcatheter coil embolization including 5 of detachable balloon embolization or homemade double-umbrella occluder embolization. Family history, clinical manifestations, analysis of arterial blood gases (ABGs)as well as images of CTA and digital subtraction angiography (DSA)pre-and post-embolizations were retrospectively collected and evaluated by professional specialists. The effects of transcatheter closure were evaluated by the improvement in saturation of O2 (SaO2)and partial pressure of O2 (PaO2)according to statistical analysis of ABGs and the findings of CTA and DSA. All the patients were followed-up for (21±1) months. Results: Primary and secondary technical success rates of this series were 75%(12/16)and 100%, respectively. Mean values of SaO2 and PaO2 before transcatheter closure were (76 ± 5)% and (46 ± 3) mmHg, respectively. Immediately after the interventional procedure, those value of mean SaO2 and PaO2 increased to(94±5)% (P<0.01) and (62±3) mmHg(P<0.05), respectively. And neither recurrence of clinical manifestations nor recanalization was revealed during the follow-up. Conclusions: Transcatheter closure of PAVMs with coils or simultaneously combining with detachable balloon embolization or homemade double-umbrella occluder are all considered safe and effective. (authors)

  4. Patent foramen ovale: indications for closure and techniques.

    Science.gov (United States)

    Taramasso, Maurizio; Nietlispach, Fabian; Maisano, Francesco; Meier, Bernhard

    2016-05-17

    Non-surgical closure of the patent foramen ovale (PFO) has been possible for 40 years and proved safe in probably a million cases performed worldwide. Nonetheless, indications are still restricted as only a few are supported by randomised data. Paradoxical embolism through a PFO causes stroke, myocardial infarction, and visceral or peripheral ischaemia. The PFO is a likely mediator of migraine, diving or high altitude sickness, dyspnoea, and sleep apnoea problems. As untoward effects of a PFO are rare and spaced widely timewise, large cohorts and long follow-ups are required to prove unequivocally that PFO closure is bene-ficial and appropriate in comparison to no treatment or medical therapy. The most compelling respective randomised data have been gathered so far in the realm of secondary prevention of cerebral attacks and migraine. Invariably they showed a numerical advantage of PFO closure with significant difference in sub-analyses. Evidence-based medicine carries a danger of underutilising valuable therapies while accumulating further data. PFO closure is an example. Its documented innocuousness invites a more proactive reflection in upcoming guidelines. At worst, PFO closure may not convey the projected amount of benefit. This even opens the door for primary prevention in some PFOs with high-risk characteristics. PMID:27174117

  5. Design, production and initial state of the closure

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    The report is included in a set of Production reports, presenting how the KBS-3 repository is designed, produced and inspected. The production reports are included in the safety report for the KBS-3 repository and repository facility. The report provides input on the initial state of the closure and plugs in underground openings other than deposition tunnels for the assessment of the long-term safety, SR-Site. The initial state refers to the properties of the engineered barriers once they have been finally placed in the KBS-3 repository and will not be further handled within the repository facility. In addition, the report provides some input to the operational safety report, SR-Operation, on how the closure and plugs shall be handled and installed. The report presents the design premises and reference designs of the closure and plugs and verifies their conformity to the design premises. It also briefly deals with the production of the closure and plugs. Finally, the initial state of the closure and plugs and their conformity to the reference designs and design premises are presented

  6. Emergent properties during dorsal closure in Drosophila morphogenesis

    International Nuclear Information System (INIS)

    Dorsal closure is an essential stage of Drosophila development that is a model system for research in morphogenesis and biological physics. Dorsal closure involves an orchestrated interplay between gene expression and cell activities that produce shape changes, exert forces and mediate tissue dynamics. We investigate the dynamics of dorsal closure based on confocal microscopic measurements of cell shortening in living embryos. During the mid-stages of dorsal closure we find that there are fluctuations in the width of the leading edge cells but the time-averaged analysis of measurements indicate that there is essentially no net shortening of cells in the bulk of the leading edge, that contraction predominantly occurs at the canthi as part of the process for zipping together the two leading edges of epidermis and that the rate constant for zipping correlates with the rate of movement of the leading edges. We characterize emergent properties that regulate dorsal closure, i.e., a velocity governor and the coordination and synchronization of tissue dynamics

  7. Capacities of Grassmann channels

    CERN Document Server

    Bradler, Kamil; Jauregui, Rocio

    2010-01-01

    A new class of quantum channels called Grassmann channels is introduced and their classical and quantum capacity is calculated. The channel class appears in a study of the two-mode squeezing operator constructed from operators satisfying the fermionic algebra. We compare Grassmann channels with the channels induced by the bosonic two-mode squeezing operator. Among other results, we challenge the relevance of calculating entanglement measures to assess or compare the ability of bosonic and fermionic states to send quantum information to uniformly accelerated frames.

  8. Ameliorated de novo transcriptome assembly using Illumina paired end sequence data with Trinity Assembler

    Directory of Open Access Journals (Sweden)

    Kiran Gopinath Bankar

    2015-09-01

    In this study, we aimed at obtaining an ameliorated de novo transcriptome assembly with sequence reads obtained from Illumina platform and assembled using Trinity Assembler. We found that, primary transcriptome assembly obtained as a result of Trinity can be ameliorated on the basis of transcript length, coverage, and depth and protein homology. Our approach to ameliorate is reproducible and could enhance the sensitivity and specificity of the assembled transcriptome which could be critical for validation of the assembled transcripts and for planning various downstream biological assays.

  9. Source and Channel Coding for Correlated Sources Over Multiuser Channels

    OpenAIRE

    Gunduz, Deniz; Erkip, Elza; Goldsmith, Andrea; Poor, H. Vincent

    2008-01-01

    Source and channel coding over multiuser channels in which receivers have access to correlated source side information is considered. For several multiuser channel models necessary and sufficient conditions for optimal separation of the source and channel codes are obtained. In particular, the multiple access channel, the compound multiple access channel, the interference channel and the two-way channel with correlated sources and correlated receiver side information are considered, and the o...

  10. Procedures and techniques for closure of near surface disposal facilities for radioactive waste

    International Nuclear Information System (INIS)

    The overall objective of this report is to provide Member States with guidance on planning and implementation of closure of near surface disposal facilities for low and intermediate level radioactive waste. The specific objectives are to review closure concepts, requirements, and components of closure systems; to discuss issues and approaches to closure, including regulatory, economic, and technical aspects; and to present major examples of closure techniques used and/or considered by Member States. Some examples of closure experience from Member States are presented in the Appendix and were indexed separately

  11. A study of fatigue crack closure using electric potential and compliance techniques

    Science.gov (United States)

    Clarke, C. K.; Cassatt, G. C.

    1976-01-01

    Compared are closure data produced on the same specimen by the crack tip compliance gage and electric potential techniques. Experiments on 7075-T651 aluminum center cracked panels produced equivalent results on closure using the two techniques. The results also indicated that closure is a function of stress ratio, specimen thickness and maximum applied stress intensity. Maximum stress intensity had a strong effect on closure in the range of applied stresses used. This dependence of closure on specimen thickness and maximum stress intensity accounts for many of the discrepencies in closure behavior reported in the literature.

  12. The 300 area waste acid treatment system closure plan

    International Nuclear Information System (INIS)

    The 300 Area Waste Acid Treatment System (WATS) is located within operable units 300-FF-2 (source) and 300-FF-5 (groundwater), as designated in the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) . Operable units 300-FF-2 and 300-FF-5 are scheduled to be remediated using the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) Remedial Investigation/Feasibility Study (RI/FS) process. Thus, any remediation of the 300 Area WATS with respect to contaminants not produced by those facilities and soils and groundwater will be deferred to the CERCLA RI/FS process. Final closure activities will be completed in 3 phases and certified in accordance with the 300 Area WATS closure plan by the Washington State Department of Ecology (Ecology) and the U.S. Environmental Protection Agency (EPA). It is anticipated that the 300 Area WATS closure would take 2 years to complete

  13. Closure testing NNPDF3.0 with LHC observables

    CERN Document Server

    Deans, Christopher S

    2015-01-01

    A thorough understanding of PDFs and their uncertainties is important for the LHC and for future collider experiments. The recently released NNPDF3.0 set was presented alongside results from closure tests, where PDF fits were performed on pseudo-data generated from a chosen input PDF set. The results there demonstrate the validity of the NNPDF methodology and also provide some information about different contributions to the PDF uncertainties. Here I present a number of additional closure test results, specifically an investigation into the effect of using cross-validation in the fits, and an assessment of the successful reproduction of LHC cross-sections in closure tests. The results are consistent with those previously shown in the NNPDF3.0 paper.

  14. Infering and Calibrating Triadic Closure in a Dynamic Network

    Science.gov (United States)

    Mantzaris, Alexander V.; Higham, Desmond J.

    In the social sciences, the hypothesis of triadic closure contends that new links in a social contact network arise preferentially between those who currently share neighbours. Here, in a proof-of-principle study, we show how to calibrate a recently proposed evolving network model to time-dependent connectivity data. The probabilistic edge birth rate in the model contains a triadic closure term, so we are also able to assess statistically the evidence for this effect. The approach is shown to work on data generated synthetically from the model. We then apply this methodology to some real, large-scale data that records the build up of connections in a business-related social networking site, and find evidence for triadic closure.

  15. INTEC CPP-603 Basin Water Treatment System Closure: Process Design

    Energy Technology Data Exchange (ETDEWEB)

    Kimmitt, Raymond Rodney; Faultersack, Wendell Gale; Foster, Jonathan Kay; Berry, Stephen Michael

    2002-09-01

    This document describes the engineering activities that have been completed in support of the closure plan for the Idaho Nuclear Technology and Engineering Center (INTEC) CPP-603 Basin Water Treatment System. This effort includes detailed assessments of methods and equipment for performing work in four areas: 1. A cold (nonradioactive) mockup system for testing equipment and procedures for vessel cleanout and vessel demolition. 2. Cleanout of process vessels to meet standards identified in the closure plan. 3. Dismantlement and removal of vessels, should it not be possible to clean them to required standards in the closure plan. 4. Cleanout or removal of pipelines and pumps associated with the CPP-603 basin water treatment system. Cleanout standards for the pipes will be the same as those used for the process vessels.

  16. Stationary neutrino radiation transport by maximum entropy closure

    International Nuclear Information System (INIS)

    The authors obtain the angular distributions that maximize the entropy functional for Maxwell-Boltzmann (classical), Bose-Einstein, and Fermi-Dirac radiation. In the low and high occupancy limits, the maximum entropy closure is bounded by previously known variable Eddington factors that depend only on the flux. For intermediate occupancy, the maximum entropy closure depends on both the occupation density and the flux. The Fermi-Dirac maximum entropy variable Eddington factor shows a scale invariance, which leads to a simple, exact analytic closure for fermions. This two-dimensional variable Eddington factor gives results that agree well with exact (Monte Carlo) neutrino transport calculations out of a collapse residue during early phases of hydrostatic neutron star formation

  17. Closure certification report: TA-35 TSL-125 surface impoundment

    International Nuclear Information System (INIS)

    This closure report documents closure activities for the TA-35 TSL-125 surface impoundment and associated structures at Los Alamos National Laboratory (the Laboratory). Prior to formal approval of the closure plan, the decision was made to proceed with closure activities to prevent any further releases from the site following informal discussions with New Mexico Environment Department (NMED) personnel. The closure plan is a revision of the previously submitted draft dated July 1988. Clean closure of the TSL-125 site was accomplished through: Removal and proper disposal of all wastes contained within the surface impoundment system; Decontamination and/or removal and proper disposal of the surface impoundment, its associated structures, and contaminated soil underlying the impoundment area; Sampling and analysis of soil to determine the presence and concentrations of any hazardous constituents remaining in the soil at the TSL-125 site; and Demonstration through a risk assessment that any constituents remaining in the soil at the TSL-125 site pose no threat to human health and the environment. All remaining soil concentrations of hazardous constituents were below health-based action levels. Analytical results indicated that benzidine, n-nitrosodimethylamine, and n-nitrosodi-n-propylamine were not detected at or above their limits of quantitation and beryllium was not present at or above its laboratory detection limit. However, the limits of quantitation and detection for these constituents were greater than their calculated health-based action levels. To demonstrate that these constituents were not present, historical data was researched and it was determined that the constituents were not utilized at the Building 125 site. 4 refs., 8 figs., 1 tab

  18. A PDF closure model for compressible turbulent chemically reacting flows

    Science.gov (United States)

    Kollmann, W.

    1992-01-01

    The objective of the proposed research project was the analysis of single point closures based on probability density function (pdf) and characteristic functions and the development of a prediction method for the joint velocity-scalar pdf in turbulent reacting flows. Turbulent flows of boundary layer type and stagnation point flows with and without chemical reactions were be calculated as principal applications. Pdf methods for compressible reacting flows were developed and tested in comparison with available experimental data. The research work carried in this project was concentrated on the closure of pdf equations for incompressible and compressible turbulent flows with and without chemical reactions.

  19. Pulmonary edema following transcatheter closure of atrial septal defect

    Directory of Open Access Journals (Sweden)

    Keerthi Chigurupati

    2015-01-01

    Full Text Available We describe an incident of development of acute pulmonary edema after the device closure of a secundum atrial septal defect in a 52-year-old lady, which was treated with inotropes, diuretics and artificial ventilation. Possibility of acute left ventricular dysfunction should be considered after the defect closure in the middle-aged patients as the left ventricular compliance may be reduced due to increased elastic stiffness and diastolic dysfunction. Baseline left atrial pressure may be > 10 mmHg in these patients. Associated risk factors for the left ventricular dysfunction are a large Qp:Qs ratio, systemic hypertension, severe pulmonary hypertension and paroxysmal atrial fibrillation.

  20. Orbit Closures in the Witt Algebra and its Dual Space

    OpenAIRE

    Mygind, Martin

    2012-01-01

    Working over an algebraically closed field of characteristic p > 3, we calculate the orbit closures in the Witt algebra W under the action of its automorphism group G. We also outline how the same techniques can be used to determine closures of orbits of all heights except p-1 (in which case we only obtain a conditional statement) in the dual space W^* under the induced action of G. As a corollary we prove that the algebra of invariants k[W^*]^G is trivial.

  1. The application of transcatheter closure procedure in congenital heart diseases

    International Nuclear Information System (INIS)

    Objective: To explore and evaluate the value of transcatheter closure procedure in congenital heart diseases. Methods: Transcatheter closure was performed in 12 patients with congenital heart diseases including 6 ventricular septal defect (VSD), 4 atrial septal defect (ASD), 2 patent ductus arteriosus (PDA), by the Amplatzer occlusion device under local or general anesthesia. Results: The procedure was successful in all patients outcoming with the disappearance of cardiac murmur. All of them could get out of the bed within 6 to 12 hours postoperatively, and were discharged from hospital after 4 to 6 days. Conclusions: Transcatheter treatment of congenital cardiac defects by Amplatzer occlusion device is less traumatic, with good effect, simultaneously

  2. Finite element analysis of residual stresses in threaded end closures

    International Nuclear Information System (INIS)

    Due to the high stress concentration at the root of the first active thread in threaded end closures of high pressure vessels, yielding may occur in this region during the application of the first pressure cycle or proof testing. This overstraining introduces residual stresses that influence the fatigue performance of the vessel. This paper presents a parametric analysis of threaded end closures using elastic and elasto-plastic finite element solutions. The results are used to discuss the influence of these residuals on the estimated fatigue life when the vessel is subjected to repeated internal pressure. A simple empirical method to allow for the Bauschinger effect of the material is also proposed

  3. Closure Plan for Active Low Level Burial Grounds

    Energy Technology Data Exchange (ETDEWEB)

    SKELLY, W.A.

    2000-11-16

    This plan has been prepared in response to direction from the U.S. Department of Energy. The purpose of the plan is to define approaches that will be implemented to ensure protection of the public and the environment when active Low-Level Burial Grounds (LLBGs) at the Hanford Site are closed. Performance assessments for active burial grounds in the 200 East and West 200 Areas provide current estimates of potential environmental contamination and doses to the ''maximum exposed individual'' from burial ground operation and closure and compare dose estimates to performance objective dose limits for the facilities. This is an Operational Closure Plan. The intent of the guidance in DOE Order 435.1 is that this plan will be a living document, like the facility performance assessments, and will be revised periodically through the operational life of the LLBGs to reflect updated information on waste inventory. management practices, facility transition planning, schedule dates, assessments of post-closure performance, and environmental consequences. Out year dates identified in this plan are tentative. A Final Closure Plan will be prepared in the future when the timing and extent of closure-related activities for LLBGs can be established with greater certainty. After current operations at the LLBGs are concluded, this plan proposes transitioning of these facilities to the Environmental Restoration Program. This action will enable the Environmental Restoration Program to design and implement consistent and coordinated final remedial actions for active and inactive LLBGs. Active and inactive burial grounds in the 200 West and 200 East Areas are commingled. This plan describes approaches that will be implemented during Interim Closure, Final Closure, and Institutional Control Periods to prepare LLBGs for surface barriers, and the construction of barriers, as well as the scope of inspection, monitoring and maintenance practices that will be performed during

  4. Sternal Closure With Tie Bands: A Word of Caution.

    Science.gov (United States)

    Samuels, Louis

    2016-08-01

    The median sternotomy for cardiac operations can be reapproximated in a variety of ways. Traditionally, sternal wires have been used in several configurations to afford satisfactory closure. Alternative techniques include cables, plates, and clip-like devices. A relatively recent addition to the menu of options is the plastic tie band. Although a few studies have suggested its efficacy, this favorable experience has not been universal. The purpose of this report is to describe a failure in closure and the reaction of the soft tissue around it. PMID:27449444

  5. Novel application of polyelectrolyte multilayers as nanoscopic closures with hermetic sealing.

    Science.gov (United States)

    Marcott, Stephanie A; Ada, Sena; Gibson, Phillip; Camesano, Terri A; Nagarajan, R

    2012-03-01

    Closure systems for personnel protection applications, such as protective clothing or respirator face seals, should provide effective permeation barrier to toxic gases. Currently available mechanical closure systems based on the hook and loop types (example, Velcro) do not provide adequate barrier to gas permeation. To achieve hermetic sealing, we propose a nonmechanical, nanoscopic molecular closure system based on complementary polyelectrolyte multilayers, one with a polycation outermost layer and the other with a polyanion outermost layer. The closure surfaces were prepared by depositing polyelectrolyte multilayers under a variety of deposition conditions, on conformable polymer substrates (thin films of polyethylene teraphthalate, PET or polyimide, PI). The hermetic sealing property of the closures was evaluated by measuring the air flow resistance using the dynamic moisture permeation cell (DMPC) at different humidity conditions. The DMPC measurements show that the polyelectrolyte multilayer closures provide significantly large resistance to air flow, approximately 20-800 times larger than that possible with conventional hook and loop type closure systems, at all humidity levels (from 5 to 95% relative humidity). Hence, from the point of view of providing a hermetic seal against toxic gas permeation, the polyelectrolyte multilayer closures are viable candidates for further engineering development. However, the adhesive strength of the multilayer closures measured by atomic force microscopy suggests that the magnitude of adhesion is much smaller than what is possible with mechanical closures. Therefore, we envisage the development of a composite closure system combining the mechanical closure to provide strong adhesion and the multilayer closure to provide hermetic sealing. PMID:22391415

  6. Compound Wiretap Channels

    Directory of Open Access Journals (Sweden)

    Shlomo Shamai (Shitz

    2009-01-01

    Full Text Available This paper considers the compound wiretap channel, which generalizes Wyner's wiretap model to allow the channels to the (legitimate receiver and to the eavesdropper to take a number of possible states. No matter which states occur, the transmitter guarantees that the receiver decodes its message and that the eavesdropper is kept in full ignorance about the message. The compound wiretap channel can also be viewed as a multicast channel with multiple eavesdroppers, in which the transmitter sends information to all receivers and keeps the information secret from all eavesdroppers. For the discrete memoryless channel, lower and upper bounds on the secrecy capacity are derived. The secrecy capacity is established for the degraded channel and the semideterministic channel with one receiver. The parallel Gaussian channel is further studied. The secrecy capacity and the secrecy degree of freedom (s.d.o.f. are derived for the degraded case with one receiver. Schemes to achieve the s.d.o.f. for the case with two receivers and two eavesdroppers are constructed to demonstrate the necessity of a prefix channel in encoder design. Finally, the multi-antenna (i.e., MIMO compound wiretap channel is studied. The secrecy capacity is established for the degraded case and an achievable s.d.o.f. is given for the general case.

  7. Compound Wiretap Channels

    Directory of Open Access Journals (Sweden)

    Kramer Gerhard

    2009-01-01

    Full Text Available Abstract This paper considers the compound wiretap channel, which generalizes Wyner's wiretap model to allow the channels to the (legitimate receiver and to the eavesdropper to take a number of possible states. No matter which states occur, the transmitter guarantees that the receiver decodes its message and that the eavesdropper is kept in full ignorance about the message. The compound wiretap channel can also be viewed as a multicast channel with multiple eavesdroppers, in which the transmitter sends information to all receivers and keeps the information secret from all eavesdroppers. For the discrete memoryless channel, lower and upper bounds on the secrecy capacity are derived. The secrecy capacity is established for the degraded channel and the semideterministic channel with one receiver. The parallel Gaussian channel is further studied. The secrecy capacity and the secrecy degree of freedom ( are derived for the degraded case with one receiver. Schemes to achieve the for the case with two receivers and two eavesdroppers are constructed to demonstrate the necessity of a prefix channel in encoder design. Finally, the multi-antenna (i.e., MIMO compound wiretap channel is studied. The secrecy capacity is established for the degraded case and an achievable is given for the general case.

  8. Irreversible inhibition of epithelial sodium channels by ultraviolet irradiation.

    OpenAIRE

    Cuthbert, A W; Fanestil, D. D.; Herrera, F. C.; Pryn, S. J.

    1982-01-01

    1 The effects of u.v. irradiation at 254 nm and 350 nm on sodium transport across frog skin epithelium have been investigated. 2 Irradiation at 254 nm but not at 350 nm produces a dose-dependent, functionally selective blockade of sodium transport. The effect is apparently due to the irreversible closure of apical sodium channels. 3 The amiloride-sensitive conductance was directly related to sodium transport as measured by short circuit current (SCC) both in normal and irradiated tissues, alt...

  9. N, P and K storage efficiency on degraded peat soil through ameliorant application

    Directory of Open Access Journals (Sweden)

    E. Maftu’ah

    2014-07-01

    Full Text Available The availability of nutrients, especially N, P, K in the degraded peat are very low. The high organic acids can decrease the soil pH, its causes the negatively charged nutrients such as nitrate and phosphate are also very low. Ameliorant contributes some cations both monovalent and polivalent which acts as a bridge cations, thus increasing the availability of nutrients, especially nitrogen and phosphate. The objective of research was to determine the storage efficiency of N, P, K on application of some ameliorants on degraded peat land. The experiment was conducted at the laboratory of ISARI, Banjarbaru. Peat soil collected from the degraded peat land at Kalampangan, Central Kalimantan. The treatments were 8 ameliorant formula and two control treatments (+NPK and -NPK. The treatments were arranged in CRD, with 3 replications, And using soil coloum (lysimeter. The leaching was conducted every once a week, with 1.25 liter of aquades and the volume of leachate would be recorded. N, P, K concentration in leachate were analyzed periodically at 1, 2, 4, 6, and 8 weeks after incubation. The results showed that the concentrations of N and K on each observation time were relatively same, but P increased significantly at 4 weeks after incubation. The highest concentrations of N, P, and K in leachate were ameliorant from 100% of chicken manure. The storage efficiency of N, P and K varied depending on the type of ameliorant. Ameliorant that improved storage efficiency of N and K was ameliorant which consist of 80% agricultural weed + 20% dolomite, whereas for P efficiency storage was on ameliorant which consist of 80% Chinese water chestnut (Eleocharis dulcis + 20% dolomite.

  10. Channel capacity and error exponents of variable rate adaptive channel coding for Rayleigh fading channels

    OpenAIRE

    Lau, KN

    1999-01-01

    We have evaluated the information theoretical performance of variable rate adaptive channel coding for Rayleigh fading channels. The channel states are detected at the receiver and fed back to the transmitter by means of a noiseless feedback link. Based on the channel state informations, the transmitter can adjust the channel coding scheme accordingly. Coherent channel and arbitrary channel symbols with a fixed average transmitted power constraint are assumed. The channel capacity and the err...

  11. Curcumin Ameliorates Ischemia-Induced Limb Injury Through Immunomodulation.

    Science.gov (United States)

    Liu, Yang; Chen, Lianyu; Shen, Yi; Tan, Tao; Xie, Nanzi; Luo, Ming; Li, Zhihong; Xie, Xiaoyun

    2016-01-01

    BACKGROUND The prevalence of peripheral arterial disease (PAD) is increasing worldwide. Currently, there is no effective treatment for PAD. Curcumin is an ingredient of turmeric that has antioxidant, anti-inflammation, and anticancer properties. In the present study we investigated the potential effect of curcumin in protecting against ischemic limb injury. MATERIAL AND METHODS We used an established hindlimb ischemia mouse model in our study. Curcumin was administrated through intraperitoneal (I.P.) injection. Immunohistochemical staining and ELISA assays were performed. Treadmill training was used to evaluate skeletal muscle functions of animals. RESULTS Our experiments using in vivo treadmill training showed that curcumin treatment improved the running capacity of animals after ischemic injury. Histological analysis revealed that curcumin treatment significantly reduced the skeletal muscle damage and fibrosis associated with ischemic injury. In order to determine the cellular and molecular mechanisms underlying curcumin-mediated tissue protection, immunohistochemical staining and ELISA assays were performed. The results showed that curcumin treatment led to less macrophage infiltration and less local inflammatory responses as demonstrated by decreasing TNF-α, IL-1, and IL-6 levels. Further immunofluorescent staining of tissue slides indicated that curcumin treatment inhibited the NF-κB signaling pathway. Finally, curcumin can inhibit NF-kB activation induced by LPS in macrophages. CONCLUSIONS Our study results show that curcumin treatment can ameliorate hindlimb injury following ischemic surgery, which suggests that curcumin could be used for PAD treatment. PMID:27302110

  12. Oleuropein ameliorates arsenic induced oxidative stress in mice.

    Science.gov (United States)

    Ogun, Metin; Ozcan, Ayla; Karaman, Musa; Merhan, Oguz; Ozen, Hasan; Kukurt, Abdulsamed; Karapehlivan, Mahmut

    2016-07-01

    The objective of this study is to investigate the potential preventive effect of oleuropein in an experimental arsenic toxicity in mice. For this purpose, mice were exposed to 5mg/kg/day sodium arsenite (NaAsO2) in drinking water and treated with 30mg/kg/day oleuropein for 15 days. At the end of the experiment, animals were sacrificed and selected organs were processed for biochemical and histopahtological investigations. Blood, liver, kidney and brain malondialdehyde (MDA) and nitric oxide (NO) levels were determined by colorimetric methods. Protein carbonyl content is measured by a commercial kit. Liver morphology and immunoreactivity for inducible NOS (iNOS) and endothelial NOS (eNOS) was evaluated microscopically. Level of NO was determined to decrease in blood and tissues whereas MDA increased in arsenic given mice. Tissue protein carbonyl content also increased in this group. Immunoreactivity for iNOS and eNOS was noted to increase with arsenic treatment. Oleuropein treatment had significant effects in normalizing the MDA and NO levels as well as protein carbonyl content. Immunohistochemical staining also showed reduction of the expression of iNOS and eNOS in liver. The results indicate that oleuropein ameliorates oxidative tissue damage by scavenging free radicals. PMID:27259345

  13. Soluble CD83 ameliorates experimental colitis in mice.

    Science.gov (United States)

    Eckhardt, J; Kreiser, S; Döbbeler, M; Nicolette, C; DeBenedette, M A; Tcherepanova, I Y; Ostalecki, C; Pommer, A J; Becker, C; Günther, C; Zinser, E; Mak, T W; Steinkasserer, A; Lechmann, M

    2014-07-01

    The physiological balance between pro- and anti-inflammatory processes is dysregulated in inflammatory bowel diseases (IBD) as in Crohn's disease and ulcerative colitis. Conventional therapy uses anti-inflammatory and immunosuppressive corticosteroids to treat acute-phase symptoms. However, low remission rate and strong side effects of these therapies are not satisfying. Thus, there is a high medical need for new therapeutic strategies. Soluble CD83, the extracellular domain of the transmembrane CD83 molecule, has been reported to have interesting therapeutic and immunosuppressive properties by suppressing dendritic cell (DC)-mediated T-cell activation and inducing tolerogenic DCs. However, the expression and function of CD83 in IBD is still unknown. Here, we show that CD83 expression is upregulated by different leukocyte populations in a chemical-induced murine colitis model. Furthermore, in this study the potential of sCD83 to modulate colitis using an experimental murine colitis model was investigated. Strikingly, sCD83 ameliorated the clinical disease symptoms, drastically reduced mortality, and strongly decreased inflammatory cytokine expression in mesenteric lymph nodes and colon. The infiltration of macrophages and granulocytes into colonic tissues was vigorously inhibited. Mechanistically, we could show that sCD83-induced expression of indolamine 2,3-dioxygenase is essential for its protective effects. PMID:24424524

  14. PPARα agonist, fenofibrate, ameliorates age-related renal injury.

    Science.gov (United States)

    Kim, Eun Nim; Lim, Ji Hee; Kim, Min Young; Kim, Hyung Wook; Park, Cheol Whee; Chang, Yoon Sik; Choi, Bum Soon

    2016-08-01

    The kidney ages quickly compared with other organs. Expression of senescence markers reflects changes in the energy metabolism in the kidney. Two important issues in aging are mitochondrial dysfunction and oxidative stress. Peroxisome proliferator-activated receptor α (PPARα) is a member of the ligand-activated nuclear receptor superfamily. PPARα plays a major role as a transcription factor that regulates the expression of genes involved in various processes. In this study, 18-month-old male C57BL/6 mice were divided into two groups, the control group (n=7) and the fenofibrate-treated group (n=7) was fed the normal chow plus fenofibrate for 6months. The PPARα agonist, fenofibrate, improved renal function, proteinuria, histological change (glomerulosclerosis and tubular interstitial fibrosis), inflammation, and apoptosis in aging mice. This protective effect against age-related renal injury occurred through the activation of AMPK and SIRT1 signaling. The activation of AMPK and SIRT1 allowed for the concurrent deacetylation and phosphorylation of their target molecules and decreased the kidney's susceptibility to age-related changes. Activation of the AMPK-FOXO3a and AMPK-PGC-1α signaling pathways ameliorated oxidative stress and mitochondrial dysfunction. Our results suggest that activation of PPARα and AMPK-SIRT1 signaling may have protective effects against age-related renal injury. Pharmacological targeting of PPARα and AMPK-SIRT1 signaling molecules may prevent or attenuate age-related pathological changes in the kidney. PMID:27130813

  15. Coniferyl Aldehyde Ameliorates Radiation Intestine Injury via Endothelial Cell Survival

    International Nuclear Information System (INIS)

    Cancer treatments related gastrointestinal toxicity has also been recognized as a significant economic burden. Especially, extensive apoptosis of microvascular endothelial cell of the lamina propria is the primary lesion initiating intestinal radiation damage after abdominal radiation therapy. Coniferyl aldehyde (CA) is phenolic compounds isolated from cork stoppers, and one of the major pyrolysis products of lignin. Shi H. was support for the empirical use of CA as a medicinal food for cardiovascular diseases. CA has positive effect in broad way but there is no consequence in radiation induced intestine damage. Here, we investigate effect of CA on small intestine after abdominal IR to mice in this study. In this study, CA increased the survival rate in C3H mice against 13.5 Gy abdominal IR. We found CA protects small intestine via preventing endothelial cell apoptosis and enhancing their angiogenic activity. CA also showed protective effect on crypt cell survival. Endothelial cell survival may affect crypt cell protection against IR. From this data, we concluded that CA is effective for protection against abdominal radiation injury. CA could ameliorate side-effect of radiation therapy

  16. Pathways Implicated in Tadalafil Amelioration of Duchenne Muscular Dystrophy.

    Science.gov (United States)

    De Arcangelis, Valeria; Strimpakos, Georgios; Gabanella, Francesca; Corbi, Nicoletta; Luvisetto, Siro; Magrelli, Armando; Onori, Annalisa; Passananti, Claudio; Pisani, Cinzia; Rome, Sophie; Severini, Cinzia; Naro, Fabio; Mattei, Elisabetta; Di Certo, Maria Grazia; Monaco, Lucia

    2016-01-01

    Numerous therapeutic approaches for Duchenne and Becker Muscular Dystrophy (DMD and BMD), the most common X-linked muscle degenerative disease, have been proposed. So far, the only one showing a clear beneficial effect is the use of corticosteroids. Recent evidence indicates an improvement of dystrophic cardiac and skeletal muscles in the presence of sustained cGMP levels secondary to a blocking of their degradation by phosphodiesterase five (PDE5). Due to these data, we performed a study to investigate the effect of the specific PDE5 inhibitor, tadalafil, on dystrophic skeletal muscle function. Chronic pharmacological treatment with tadalafil has been carried out in mdx mice. Behavioral and physiological tests, as well as histological and biochemical analyses, confirmed the efficacy of the therapy. We then performed a microarray-based genomic analysis to assess the pattern of gene expression in muscle samples obtained from the different cohorts of animals treated with tadalafil. This scrutiny allowed us to identify several classes of modulated genes. Our results show that PDE5 inhibition can ameliorate dystrophy by acting at different levels. Tadalafil can lead to (1) increased lipid metabolism; (2) a switch towards slow oxidative fibers driven by the up-regulation of PGC-1α; (3) an increased protein synthesis efficiency; (4) a better actin network organization at Z-disk. PMID:26097015

  17. Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

    Institute of Scientific and Technical Information of China (English)

    Ling Fang; Lei Wang; Qi Zheng; Tao Yang; Hui Zhao; Qiuxia Zhang; Kangning Li; Li Zhou; Haiyang Gong; Yongping Fan

    2013-01-01

    A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly cal ed Er-huang Formula) in combination with conventional therapy is an effective prescription for the treat-ment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis re-mains unclear. In this study, a MOG 35-55-immunized C57BL/6 mouse model of experimental au-toimmune encephalomyelitis was intragastrical y administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoim-mune encephalomyelitis was mediated by amelioration of axonal damage and promotion of rege-neration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.

  18. Coniferyl Aldehyde Ameliorates Radiation Intestine Injury via Endothelial Cell Survival

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Ye Ji; Jung, Myung Gu; Lee, Yoonjin; Lee, Haejune [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Lee, Yunsil [Ewha Woman' s Univ., Seoul (Korea, Republic of); Ko, Younggyu [Korea Univ., Seoul (Korea, Republic of)

    2014-05-15

    Cancer treatments related gastrointestinal toxicity has also been recognized as a significant economic burden. Especially, extensive apoptosis of microvascular endothelial cell of the lamina propria is the primary lesion initiating intestinal radiation damage after abdominal radiation therapy. Coniferyl aldehyde (CA) is phenolic compounds isolated from cork stoppers, and one of the major pyrolysis products of lignin. Shi H. was support for the empirical use of CA as a medicinal food for cardiovascular diseases. CA has positive effect in broad way but there is no consequence in radiation induced intestine damage. Here, we investigate effect of CA on small intestine after abdominal IR to mice in this study. In this study, CA increased the survival rate in C3H mice against 13.5 Gy abdominal IR. We found CA protects small intestine via preventing endothelial cell apoptosis and enhancing their angiogenic activity. CA also showed protective effect on crypt cell survival. Endothelial cell survival may affect crypt cell protection against IR. From this data, we concluded that CA is effective for protection against abdominal radiation injury. CA could ameliorate side-effect of radiation therapy.

  19. Emodin ameliorates lipopolysaccharides-induced corneal inflammation in rats

    Institute of Scientific and Technical Information of China (English)

    Guo-Ling; Chen; Jing-Jing; Zhang; Xin; Kao; Lu-Wan; Wei; Zhi-Yu; Liu

    2015-01-01

    · AIM: To investigate the effect of emodin on pseudomonas aeruginosa lipopolysaccharides(LPS)-induced corneal inflammation in rats.· METHODS: Corneal infection was induced by pseudomonas aeruginosa LPS in Wistar rats. The inflammation induced by LPS were examined by slit lamp microscope and cytological checkup of aqueous humor.Corneal tissue structure was observed by hematoxylin and eosin(HE) staining. The activation of nuclear factor kappa B(NF-κB) was determined by Western blot.Messenger ribonucleic acid(m RNA) of tumor necrosis factor-α(TNF-α) and intercellular adhesion molecule-1(ICAM-1) in LPS-challenged rat corneas were measured with reverse transcription-polymerase chain reaction(RT-PCR).· RESULTS: Typical manifestations of acute corneal inflammation were observed in LPS-induce rat model,and the corneal inflammatory response and structure were improved in rats pretreated with emodin. Treatment with emodin could improve corneal structure, reduce corneal injure by reducing corneal inflammatory response. Emodin could inhibit the decreasing lever of inhibitor of kappa B alpha(IкBα) express, and the m RNA expression of TNF-α and ICAM-1 in corneal tissues was also inhibited by emodin. The differences were statistically significant between groups treated with emodin and those without treatment(P <0.01).·CONCLUSION: Emodin could ameliorate LPS-induced corneal inflammation, which might via inhibiting the activation of NF-κB.

  20. Transcranial amelioration of inflammation and cell death after brain injury

    Science.gov (United States)

    Roth, Theodore L.; Nayak, Debasis; Atanasijevic, Tatjana; Koretsky, Alan P.; Latour, Lawrence L.; McGavern, Dorian B.

    2014-01-01

    Traumatic brain injury (TBI) is increasingly appreciated to be highly prevalent and deleterious to neurological function. At present, no effective treatment options are available, and little is known about the complex cellular response to TBI during its acute phase. To gain insights into TBI pathogenesis, we developed a novel murine closed-skull brain injury model that mirrors some pathological features associated with mild TBI in humans and used long-term intravital microscopy to study the dynamics of the injury response from its inception. Here we demonstrate that acute brain injury induces vascular damage, meningeal cell death, and the generation of reactive oxygen species (ROS) that ultimately breach the glial limitans and promote spread of the injury into the parenchyma. In response, the brain elicits a neuroprotective, purinergic-receptor-dependent inflammatory response characterized by meningeal neutrophil swarming and microglial reconstitution of the damaged glial limitans. We also show that the skull bone is permeable to small-molecular-weight compounds, and use this delivery route to modulate inflammation and therapeutically ameliorate brain injury through transcranial administration of the ROS scavenger, glutathione. Our results shed light on the acute cellular response to TBI and provide a means to locally deliver therapeutic compounds to the site of injury.

  1. Osteitis pubis ameliorated after tooth extraction: a case report.

    Science.gov (United States)

    Fukushi, Jun-ichi; Nakashima, Yasuharu; Iwamoto, Yukihide

    2013-03-01

    Osteitis pubis is a non-infective inflammation of the symphysis pubis, which is known to be associated with trauma, athletic exertion, urological or gynecological surgery, or with rheumatic conditions such as seronegative spondyloarthropathies. In this report, we describe a case of osteitis pubis whose symptoms were completely ameliorated following tooth extraction attributable to periodontitis. A 57-year-old female patient developed osteitis pubis, presenting with pain in the groin area with an elevated Creactive protein (CRP; 4.4 mg/dl) and radiological erosive changes in symphysis pubis. Prednisolone (5 mg/day) and etodolac were prescribed, but the patient's symptoms improved only partially and remained persistent. One year from the patient's first visit, three teeth were extracted due to severe chronic periodontitis, which she had been suffering from for years. Soon after the above tooth extraction, her symptoms appeared completely resolved, and the patient's CRP was decreased to nearly normal levels in 4 weeks. Human leukocyte antigen (HLA)-typing analysis revealed a positive result for HLA-A11, A24, and B54. Because HLA-B54 cross-reacts with HLA-B27, the patient's osteitis pubis was considered to be a form of reactive arthritis associated with periodontitis. PMID:23599946

  2. Apricot Kernel Oil Ameliorates Cyclophosphamide-Associated Immunosuppression in Rats.

    Science.gov (United States)

    Tian, Honglei; Yan, Haiyan; Tan, Siwei; Zhan, Ping; Mao, Xiaoying; Wang, Peng; Wang, Zhouping

    2016-08-01

    The effects of dietary apricot kernel oil (AKO), which contains high levels of oleic and linoleic acids and lower levels of α-tocopherol, were evaluated in a rat model of cyclophosphamide-induced immunosuppression. Rats had intraperitoneal injection with cyclophosphamide to induce immunosuppression and were then infused with AKO or normal saline (NS) for 4 weeks. Enzyme-linked immunosorbent assays were used to detect antimicrobial factors in lymphocytes and anti-inflammatory factors in hepatocytes. Hematoxylin & eosin staining was conducted prior to histopathological analysis of the spleen, liver, and thymus. Significant differences were observed between the immune functions of the healthy control group, the normal saline group, and the AKO group. Compared to the normal saline-treated group, lymphocytes isolated from rats administered AKO showed significant improvement in immunoglobulin (Ig)A, IgM, IgG, interleukin (IL)-2, IL-12, and tumor necrosis factor-α (TNF-α) levels (p cyclophosphamide-associated organ degeneration. These results suggested that AKO may enhance the immune system in vivo. These effects may reflect the activities of intermediate oleic and linoleic acid metabolites, which play a vital role in the immune system, and the α-tocopherol in AKO may further enhance this phenomenon. Thus, the use of AKO as a nutritional supplement can be proposed to ameliorate chemotherapy-associated immunosuppression. PMID:27262314

  3. Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP.

    Science.gov (United States)

    Han, Na-Ra; Moon, Phil-Dong; Kim, Hyung-Min; Jeong, Hyun-Ja

    2014-01-15

    Atopic dermatitis (AD) is a common skin disease that greatly worsens quality of life. Thymic stromal lymphopoietin (TSLP) plays a decisive role in the development of AD. The purpose of this study is to examine whether tryptanthrin (TR) would suppress AD through the regulation of TSLP. We analyzed the effect of TR on the level of TSLP from phorbol myristate acetate/calcium ionophore A23187-activated human mast cell line, HMC-1 cells, in 2,4-dinitrofluorobenzene-induced AD-like skin lesions of NC/Nga mice, and in anti-CD3/anti-CD28-stimulated splenocytes. TR significantly suppressed the level of intracellular calcium and the production and mRNA expression of TSLP through the blockade of receptor-interacting protein 2/caspase-1/nuclear factor-κB pathway in the activated HMC-1 cells. TR also significantly suppressed the levels of histidine decarboxylase and IL-1β. Furthermore, TR ameliorated clinical symptoms in the AD model. TR significantly reduced the levels of TSLP, IL-4, IFN-γ, IL-6, TNF-α, thymus and activation-regulated chemokine, and caspase-1 in AD skin lesions. Also, TR significantly reduced the serum levels of histamine and IL-4 in the AD model. Finally, TR significantly inhibited the production of IL-4, IFN-γ, and TNF-α from the stimulated splenocytes. Taken together, TR exhibits the potential to be a therapeutic agent for AD through down-regulation of TSLP. PMID:24295961

  4. Yangjing Capsule Ameliorates Spermatogenesis in Male Mice Exposed to Cyclophosphamide

    Directory of Open Access Journals (Sweden)

    Hongle Zhao

    2015-01-01

    Full Text Available Yangjing capsule (YC, a traditional Chinese compound herbal preparation, has been proven as an effective drug to improve spermatogenesis in clinical practice. However, its pharmacological mechanisms were not fully clarified. This study was designed to investigate the protective effects of YC on spermatogenesis in the mouse model of spermatogenesis dysfunction induced by cyclophosphamide (CP. The administration of YC significantly increased the epididymal index, sperm count, and sperm motility of model mice. Histopathological changes demonstrated that CP caused obvious structural damage to testis, which were reversed by the administration of YC. Results from TUNEL assay showed that treatment with YC dramatically decreased the apoptosis of spermatogenic cell induced by CP. Moreover, YC treatment could inhibit the mRNA and protein expression of Bax to Bcl-2 and also raised expression of AR at both mRNA and protein levels. These data suggest that YC might ameliorate spermatogenesis in male mice exposed to CP through inhibiting the apoptosis of spermatogenic cell and enhancing the actions of testosterone in spermatogenesis.

  5. Cellulose supplementation early in life ameliorates colitis in adult mice.

    Directory of Open Access Journals (Sweden)

    Dorottya Nagy-Szakal

    Full Text Available Decreased consumption of dietary fibers, such as cellulose, has been proposed to promote the emergence of inflammatory bowel diseases (IBD: Crohn disease [CD] and ulcerative colitis [UC] where intestinal microbes are recognized to play an etiologic role. However, it is not known if transient fiber consumption during critical developmental periods may prevent consecutive intestinal inflammation. The incidence of IBD peaks in young adulthood indicating that pediatric environmental exposures may be important in the etiology of this disease group. We studied the effects of transient dietary cellulose supplementation on dextran sulfate sodium (DSS colitis susceptibility during the pediatric period in mice. Cellulose supplementation stimulated substantial shifts in the colonic mucosal microbiome. Several bacterial taxa decreased in relative abundance (e.g., Coriobacteriaceae [p = 0.001], and other taxa increased in abundance (e.g., Peptostreptococcaceae [p = 0.008] and Clostridiaceae [p = 0.048]. Some of these shifts persisted for 10 days following the cessation of cellulose supplementation. The changes in the gut microbiome were associated with transient trophic and anticolitic effects 10 days following the cessation of a cellulose-enriched diet, but these changes diminished by 40 days following reversal to a low cellulose diet. These findings emphasize the transient protective effect of dietary cellulose in the mammalian large bowel and highlight the potential role of dietary fibers in amelioration of intestinal inflammation.

  6. Ameliorative property of Teucrium polium on second degree burn

    Directory of Open Access Journals (Sweden)

    Ansari Roya

    2013-01-01

    Full Text Available Introduction: Traditionally, burn wound healing activities have been claimed for Teucrium polium. Teucrium polium possesses antioxidant and inflammatory activities and seems to ameliorate burn wound healing. This study was performed to evaluate the effects of Teucrium polium on burn healing in Balb/C mice. Materials and Methods: In this preclinical experimental study 56 mice were randomly designated into 4 equal groups. Burn wounds were made using a hot plate with a surface area of 1.5 cm2. Animals were treated with Teucrium 2%, Silver sulfadiazine or Vaseline 2 times per day for 21 days. The forth group received no treatment. Results: The percentage of burn wounds healing and total time required for complete healing were evaluated and compared in different groups. Data were analyzed using ANOVA test. Conclusion: Teucrium extract accelerated the burn wound healing more rapidly than control groups (p<0.01. Teucrium polium is effective on burn wounds healing and might be beneficial in these groups of patients.

  7. Quantum broadcast channels

    CERN Document Server

    Yard, J; Devetak, I; Yard, Jon; Hayden, Patrick; Devetak, Igor

    2006-01-01

    We analyze quantum broadcast channels, which are quantum channels with a single sender and many receivers. Focusing on channels with two receivers for simplicity, we generalize a number of results from the network Shannon theory literature which give the rates at which two senders can receive a common message, while a personalized one is sent to one of them. Our first collection of results applies to channels with a classical input and quantum outputs. The second class of theorems we prove concern sending a common classical message over a quantum broadcast channel, while sending quantum information to one of the receivers. The third group of results we obtain concern communication over an isometry, giving the rates at quantum information can be sent to one receiver, while common quantum information is sent to both, in the sense that tripartite GHZ entanglement is established. For each scenario, we provide an additivity proof for an appropriate class of channels, yielding single-letter characterizations of the...

  8. Amelioration and reforestation of sulfurous mine soils in Lusatia (eastern Germany)

    International Nuclear Information System (INIS)

    In Germany nearly 1.550 km2 have been claimed by brown coal mining until now. Mine soils formed of carboniferous and sulfurous overburden are classified as sulfurous mine soils. They remain vegetation-free for decades and may be cultivated only after soil amelioration. The objective of amelioration is a sustained improvement of soil reaction. Lime requirement for the achievement of a certain pH-value is calculated from acid-base-balance (SBB). Lime fertilizers and base-rich brown coal ashes are used for amelioration. As ashes have several advantages, their application is recommended. The ameliorative application of lime fertilizer or brown coal ash should be incorporated intensively into the soil to a depth of 60 cm, better 100 cm. Amelioration includes a mineral fertilization with N, P and K. Afforestation with Pinus sylvestris, Pinus nigra, Larix decidua, Larix eurolepis. Tilia cordata, Quercus rubra and Quercus petraea on ameliorated mine soils show surprising good results. Multi-species stands have very positive effects on soil formation. Raw humus is formed under pine and larch, and under deciduous trees moder and mull with higher bioactivity and better development of water and nutrient balance in the topsoil are found. 55 refs., 6 figs., 4 tabs

  9. Open-channel hydraulics

    International Nuclear Information System (INIS)

    This text discusses the following: concepts of fluid flow; the momentum principle; computation of uniform flow; design of channels; and turbulent diffusion and dispersion in steady open-channel flow. Emphasis is concerned only with the flow of water in channels where the water is not transporting significant quantities of air or sediment. The text contains quite a few examples demonstrating the application of the presented principles

  10. Bank Liabilities Channel

    OpenAIRE

    Quadrini, Vincenzo

    2014-01-01

    The financial intermediation sector is important not only for channeling resources from agents in excess of funds to agents in need of funds (lending channel). By issuing liabilities it also creates financial assets held by other sectors of the economy for insurance purpose. When the intermediation sector creates less liabilities or their value falls, agents are less willing to engage in activities that are individually risky but desirable in aggregate (bank liabilities channel). The paper st...

  11. Bank Liabilities Channel

    OpenAIRE

    Vincenzo Quadrini

    2015-01-01

    The financial intermediation sector is important not only for channeling resources from agents in excess of funds to agents in need of funds (lending channel). By issuing liabilities it also creates financial assets held by other sectors of the economy for insurance purpose. When the intermediation sector creates less liabilities or their value falls, agents are less willing to engage in activities that are individually risky but desirable in aggregate (bank liabilities channel). The paper st...

  12. HIPPI and Fibre Channel

    International Nuclear Information System (INIS)

    The High-Performance Parallel Interface (HIPPI) and Fibre Channel are near-gigabit per second data communications interfaces being developed in ANSI standards Task Group X3T9.3. HIPPI is the current interface of choice in the high-end and supercomputer arena, and Fibre Channel is a follow-on effort. HIPPI came from a local area network background, and Fibre Channel came from a mainframe to peripheral interface background

  13. Symmetrization for redundant channels

    Science.gov (United States)

    Tulplue, Bhalchandra R. (Inventor); Collins, Robert E. (Inventor)

    1988-01-01

    A plurality of redundant channels in a system each contain a global image of all the configuration data bases in each of the channels in the system. Each global image is updated periodically from each of the other channels via cross channel data links. The global images of the local configuration data bases in each channel are separately symmetrized using a voting process to generate a system signal configuration data base which is not written into by any other routine and is available for indicating the status of the system within each channel. Equalization may be imposed on a suspect signal and a number of chances for that signal to heal itself are provided before excluding it from future votes. Reconfiguration is accomplished upon detecting a channel which is deemed invalid. A reset function is provided which permits an externally generated reset signal to permit a previously excluded channel to be reincluded within the system. The updating of global images and/or the symmetrization process may be accomplished at substantially the same time within a synchronized time frame common to all channels.

  14. Simultaneous Single Tooth Intrusion and Diastema Closure: A Simplified Approach.

    Science.gov (United States)

    Jain, Isha; Hattarki, Rohan S

    2015-01-01

    Re-treatment of relapse with a full bonded appliance following an extensive course of fixed mechanotherapy is psychologically unacceptable and time-consuming for the patient. This article presents a simple removable appliance, which intrudes an extruded maxillary incisor with simultaneous closure of a diastema in an effective and fast way, reducing the need for re-treatment with fixed mechanotherapy. PMID:27029090

  15. Engineering study for closure of 209E facility

    International Nuclear Information System (INIS)

    This document is an engineering study for evaluating alternatives to determine the most cost effective closure plan for the 209E Facility, Critical Mass Laboratory. This laboratory is located in the 200 East Area of the Hanford Site and contains a Critical Assembly Room and a Mix room were criticality experiments were once performed

  16. Phase Closure at 691 GHz using the Submillimeter Array

    CERN Document Server

    Hunter, T R; Peck, A B; Christensen, R D; Blundell, R; Camacho, A; Patt, F; Sakamoto, K; Young, K H

    2007-01-01

    Phase closure at 682 GHz and 691 GHz was first achieved using three antennas of the Submillimeter Array (SMA) interferometer located on Mauna Kea, Hawaii. Initially, phase closure was demonstrated at 682.5 GHz on Sept. 19, 2002 using an artificial ground-based "beacon" signal. Subsequently, astronomical detections of both Saturn and Uranus were made at the frequency of the CO(6-5) transition (691.473 GHz) on all three baselines on Sept. 22, 2002. While the larger planets such as Saturn are heavily resolved even on these short baselines (25.2m, 25.2m and 16.4m), phase closure was achieved on Uranus and Callisto. This was the first successful experiment to obtain phase closure in this frequency band. The CO(6-5) line was also detected towards Orion BN/KL and other Galactic sources, as was the vibrationally-excited 658 GHz water maser line toward evolved stars. We present these historic detections, as well as the first arcsecond-scale images obtained in this frequency band.

  17. Factors influencing ring closure through olefin metathesis - A perspective

    Indian Academy of Sciences (India)

    Subrata Ghosh; Sarita Ghosh; Niladri Sarkar

    2006-05-01

    Success of ring closure reactions of substrates having two terminal alkenes through olefin metathesis depends on a number of factors such as catalysts, nature and size of the rings to be formed and the substituents/functional groups present on the alkenes as well as at the allylic position. This article presents an overview of these influencing factors with illustrative examples.

  18. Device Closure of Small Ventricular Septal Defects: When and Why?

    Directory of Open Access Journals (Sweden)

    IB Vijayalakshmi

    2014-10-01

    Full Text Available Ventricular septal defect (VSD accounts for approximately 20-30 % of all forms of congenital heart disease (CHD. They were traditionally closed surgically in the past. The surgery though safe carries the risk of morbidity, complete heart block, wound infection and thoracotomy scar on the chest. On weighing the risk and benefit, the small VSDs were not submitted to surgery in the past. So for many years it has been taught that the small VSDs are to be left alone and surgery is not recommended. Many clinicians believed in spontaneous closure of VSDs. Hence they advised the parents to wait for spontaneous closure till the child is 9 years old. But what if the VSD does not close by 10 years is the question. Are they normal as grown up congenital heart (GUCH. The Jane Somerville GUCH unit showed that spontaneous closure occurred only in 10% between the age of 17 and 45 (mean - 27 years in small VSDs in adults. What is worth noting is about 25% had serious complications: infective endocarditis (11%, progressive aortic regurgitation (5%, age-related symptomatic arrhythmias (8.5% like atrial fibrillation. This means that asymptomatic small VSDs in childhood is not necessarily benign during adult life. This raises the question, when we have a safe non-surgical device closure available to close the small VSDs, should we put the future lives of the young in danger by not giving the benefit of technology to them?

  19. Laparotomy for peritonitis: primary or delayed primary closure

    International Nuclear Information System (INIS)

    Background: Although literature does not provide a level-1 evidence to support either method of closure, various studies have shown a reduced frequency of superficial surgical site infection with delayed primary closure (DPC) as opposed to primary closure (PC). Nevertheless, PC is still preferred by most. surgeons to avoid a second procedure. This study was conducted with the objective to compare the frequency of wound infection and duration of hospitalization among patients undergoing primary and delayed primary closure of the skin wound following laparotomy for peritonitis. Method: A randomized controlled trial comprising 70 patients: Thirty-five patients underwent PC (Group-A) and 35 DPC (Group-B). Frequency of wound infection during follow up period and duration of hospital stay was noted in both groups. Results: In group-A, 18 (51.43 percentage) patients showed wound infection while in group-B, it was 9 (25.71 percentage) with p=0.027. Mean hospital stay recorded in group-A was 7.03 days ± 1.81, and for group-B, it was 6.34 days±4.14 (p=0.372). Conclusion: DPC for surgical wounds is better than PC technique as it decreases the frequency of wound infection during follow-up period without any significant increase in duration of hospital stay. (author)

  20. From Castalia to Wikipedia: Openness and Closure in Knowledge Communities

    Science.gov (United States)

    Roberts, Peter; Peters, Michael A.

    2011-01-01

    This article explores different forms of openness and closure in two knowledge communities: the fictional world of Castalia in Hermann Hesse's great work "The Glass Bead Game", and the twenty-first-century cyberspatial universe of Wikipedia. These two worlds differ in some important respects, but they also share a number of educationally…

  1. A simple technique for tracheocutaneous fistula surgical closure

    Directory of Open Access Journals (Sweden)

    Armando De Virgilio

    2015-10-01

    Full Text Available Tracheocutaneous fistula (TCF is commonly regarded as a pathologic complication of temporary tracheostomy, resulting from failure of the spontaneous tracheostomy closure after decannulation. The aim of the present study is to describe and to report the results of a our simple TCF closure surgical technique. Ten patients with TCF were prospectively enrolled at the Sensory Organs Department of Policlinico “Umberto I”, “Sapienza” University of Rome between February 2011 and May 2013. The surgical procedure, performed under local anesthesia, is decribed in detail. TCF surgical closure was accomplished successfully in all cases. All patients experienced regular postoperative courses during the first week without complications in terms of bleeding or airway compromise. Only 1 (10% patient required a surgical revision consisting of debriding of the margins and closure with simple sutures. The reported technique was shown to be safe, simple and feasible. However particular caution should be required in patients with chronic aspiration and cough which may cause wound dehiscence and fistula recurrence in the early post-operative period.

  2. Theoretical study of void closure in nonlinear plastic materials

    Institute of Scientific and Technical Information of China (English)

    Xiao-xun ZHANG; Zhen-shan CUI

    2009-01-01

    Void closing from a spherical shape to a crack is investigated quantitatively in the present study. The constitutive relation of the void-free matrix is assumed to obey the Norton power law. A representative volume element (RVE) which includes matrix and void is employed and a Rayleigh-Ritz procedure is developed to study the deformation-rates of a spherical void and a penny-shaped crack. Based on an approximate interpolation scheme,an analytical model for void closure in nonlinear plastic materials is established. It is found that the local plastic flows of the matrix material are the main mechanism of void deformation. It is also shown that the relative void volume during the deformation depends on the Norton exponent,on the far-field stress triaxiality,as well as on the far-field effective strain. The predictions of void closure using the present model are compared with the corresponding results in the literature,showing good agreement.The model for void closure provides a novel way for process design and optimization in terms of elimination of voids in billets because the model for void closure can easily be applied in the CAE analysis.

  3. Underground storage tank 511-D1U1 closure plan

    Energy Technology Data Exchange (ETDEWEB)

    Mancieri, S.; Giuntoli, N.

    1993-09-01

    This document contains the closure plan for diesel fuel underground storage tank 511-D1U1 and appendices containing supplemental information such as staff training certification and task summaries. Precision tank test data, a site health and safety plan, and material safety data sheets are also included.

  4. Application of statistical dynamical turbulence closures to data assimilation

    International Nuclear Information System (INIS)

    We describe the development of an accurate yet computationally tractable statistical dynamical closure theory for general inhomogeneous turbulent flows, coined the quasi-diagonal direct interaction approximation closure (QDIA), and its application to problems in data assimilation. The QDIA provides prognostic equations for evolving mean fields, covariances and higher-order non-Gaussian terms, all of which are also required in the formulation of data assimilation schemes for nonlinear geophysical flows. The QDIA is a generalization of the class of direct interaction approximation theories, initially developed by Kraichnan (1959 J. Fluid Mech. 5 497) for isotropic turbulence, to fully inhomogeneous flows and has been further generalized to allow for both inhomogeneous and non-Gaussian initial conditions and long integrations. A regularization procedure or empirical vertex renormalization that ensures correct inertial range spectra is also described. The aim of this paper is to provide a coherent mathematical description of the QDIA turbulence closure and closure-based data assimilation scheme we have labeled the statistical dynamical Kalman filter. The mathematical formalism presented has been synthesized from recent works of the authors with some additional material and is presented in sufficient detail that the paper is of a pedagogical nature.

  5. Data-driven non-Markovian closure models

    CERN Document Server

    Kondrashov, Dmitri; Ghil, Michael

    2014-01-01

    This paper has two interrelated foci: (i) obtaining stable and efficient data-driven closure models by using a multivariate time series of partial observations from a large-dimensional system; and (ii) comparing these closure models with the optimal closures predicted by the Mori-Zwanzig (MZ) formalism of statistical physics. Multilayer stochastic models (MSMs) are introduced as both a generalization and a time-continuous limit of existing multilevel, regression-based approaches to closure in a data-driven setting; these approaches include empirical model reduction (EMR), as well as more recent multi-layer modeling. It is shown that the multilayer structure of MSMs can provide a natural Markov approximation to the generalized Langevin equation (GLE) of the MZ formalism. A simple correlation-based stopping criterion for an EMR-MSM model is derived to assess how well it approximates the GLE solution. Sufficient conditions are derived on the structure of the nonlinear cross-interactions between the constitutive ...

  6. Maxey Flats low-level waste disposal site closure activities

    International Nuclear Information System (INIS)

    The Maxey Flats Radioactive Waste Disposal Facility in Fleming County, Kentucky is in the process of being closed. The facility opened for commercial business in the spring of 1963 and received approximately 4.75 million cubic feet of radioactive waste by the time it was closed in December of 1977. During fourteen years of operation approximately 2.5 million curies of by-product material, 240,000 kilograms of source material, and 430 kilograms of special nuclear material were disposed. The Commonwealth purchased the lease hold estate and rights in May 1978 from the operating company. This action was taken to stabilize the facility and prepare it for closure consisting of passive care and monitoring. To prepare the site for closure, a number of remedial activities had to be performed. The remediation activities implemented have included erosion control, surface drainage modifications, installation of a temporary plastic surface cover, leachate removal, analysis, treatment and evaporation, US DOE funded evaporator concentrates solidification project and their on-site disposal in an improved disposal trench with enhanced cover for use in a humid environment situated in a fractured geology, performance evaluation of a grout injection demonstration, USGS subsurface geologic investigation, development of conceptual closure designs, and finally being added to the US EPA National Priority List for remediation and closure under Superfund. 13 references, 3 figures

  7. Cystic duct closure by sealing with bipolar electrocoagulation

    DEFF Research Database (Denmark)

    Schulze, S; Damgaard, B; Jørgensen, Lars Nannestad; Larsen, S S; Kristiansen, V B

    2010-01-01

    BACKGROUND: Cystic duct leakage after cholecystectomy is not uncommon and is a potentially serious complication. The aim of this study was to assess a bipolar sealing system (LigaSure) for closure of the cystic duct. METHODS: The records from consecutive laparoscopic cholecystectomies performed in...

  8. REDUCED HEATING LEVEL DURING THE END-OF-YEAR CLOSURE

    CERN Multimedia

    ST/CV-ST/TFM Groups

    2000-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 21 December 2000 at the latest (tel. 74195 or 72201).

  9. REDUCED HEATING LEVEL DURING THE END-OF-YEAR CLOSURE

    CERN Multimedia

    ST/CV - ST/TFM Groups

    2001-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 20 December 2001 at the latest (tel.74195 or 72201).

  10. Reduced heating level during the end-of-year closure

    CERN Multimedia

    2003-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 18 December 2003 at the latest (tel. 74195 or 72201). ST/CV - ST/FM Groups

  11. REDUCED HEATING LEVEL DURING THE END-OF-YEAR CLOSURE

    CERN Multimedia

    ST/CV - ST/FM Groups

    2002-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 19 December 2002 at the latest (tel. 74195 or 72201). ST/CV - ST/FM Groups

  12. A STUDY ON CLOSURE OF TYMPANIC MEMBRANE BY 10% TCA

    Directory of Open Access Journals (Sweden)

    Sathi Raju Velaga

    2015-11-01

    Full Text Available Purpose of closure of central perforation of Tympanic Membrane is to restore continuity and restore hearing.(1 this study was carried on 50 patient with small dry central perforation over a duration of two years with success rate of seventy seven percentage and 5-6% dB hearing improvement.

  13. Multivariate moment closure techniques for stochastic kinetic models

    Energy Technology Data Exchange (ETDEWEB)

    Lakatos, Eszter, E-mail: e.lakatos13@imperial.ac.uk; Ale, Angelique; Kirk, Paul D. W.; Stumpf, Michael P. H., E-mail: m.stumpf@imperial.ac.uk [Department of Life Sciences, Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London SW7 2AZ (United Kingdom)

    2015-09-07

    Stochastic effects dominate many chemical and biochemical processes. Their analysis, however, can be computationally prohibitively expensive and a range of approximation schemes have been proposed to lighten the computational burden. These, notably the increasingly popular linear noise approximation and the more general moment expansion methods, perform well for many dynamical regimes, especially linear systems. At higher levels of nonlinearity, it comes to an interplay between the nonlinearities and the stochastic dynamics, which is much harder to capture correctly by such approximations to the true stochastic processes. Moment-closure approaches promise to address this problem by capturing higher-order terms of the temporally evolving probability distribution. Here, we develop a set of multivariate moment-closures that allows us to describe the stochastic dynamics of nonlinear systems. Multivariate closure captures the way that correlations between different molecular species, induced by the reaction dynamics, interact with stochastic effects. We use multivariate Gaussian, gamma, and lognormal closure and illustrate their use in the context of two models that have proved challenging to the previous attempts at approximating stochastic dynamics: oscillations in p53 and Hes1. In addition, we consider a larger system, Erk-mediated mitogen-activated protein kinases signalling, where conventional stochastic simulation approaches incur unacceptably high computational costs.

  14. Multivariate moment closure techniques for stochastic kinetic models.

    Science.gov (United States)

    Lakatos, Eszter; Ale, Angelique; Kirk, Paul D W; Stumpf, Michael P H

    2015-09-01

    Stochastic effects dominate many chemical and biochemical processes. Their analysis, however, can be computationally prohibitively expensive and a range of approximation schemes have been proposed to lighten the computational burden. These, notably the increasingly popular linear noise approximation and the more general moment expansion methods, perform well for many dynamical regimes, especially linear systems. At higher levels of nonlinearity, it comes to an interplay between the nonlinearities and the stochastic dynamics, which is much harder to capture correctly by such approximations to the true stochastic processes. Moment-closure approaches promise to address this problem by capturing higher-order terms of the temporally evolving probability distribution. Here, we develop a set of multivariate moment-closures that allows us to describe the stochastic dynamics of nonlinear systems. Multivariate closure captures the way that correlations between different molecular species, induced by the reaction dynamics, interact with stochastic effects. We use multivariate Gaussian, gamma, and lognormal closure and illustrate their use in the context of two models that have proved challenging to the previous attempts at approximating stochastic dynamics: oscillations in p53 and Hes1. In addition, we consider a larger system, Erk-mediated mitogen-activated protein kinases signalling, where conventional stochastic simulation approaches incur unacceptably high computational costs. PMID:26342359

  15. Multivariate moment closure techniques for stochastic kinetic models

    International Nuclear Information System (INIS)

    Stochastic effects dominate many chemical and biochemical processes. Their analysis, however, can be computationally prohibitively expensive and a range of approximation schemes have been proposed to lighten the computational burden. These, notably the increasingly popular linear noise approximation and the more general moment expansion methods, perform well for many dynamical regimes, especially linear systems. At higher levels of nonlinearity, it comes to an interplay between the nonlinearities and the stochastic dynamics, which is much harder to capture correctly by such approximations to the true stochastic processes. Moment-closure approaches promise to address this problem by capturing higher-order terms of the temporally evolving probability distribution. Here, we develop a set of multivariate moment-closures that allows us to describe the stochastic dynamics of nonlinear systems. Multivariate closure captures the way that correlations between different molecular species, induced by the reaction dynamics, interact with stochastic effects. We use multivariate Gaussian, gamma, and lognormal closure and illustrate their use in the context of two models that have proved challenging to the previous attempts at approximating stochastic dynamics: oscillations in p53 and Hes1. In addition, we consider a larger system, Erk-mediated mitogen-activated protein kinases signalling, where conventional stochastic simulation approaches incur unacceptably high computational costs

  16. Slow closure of denaturation bubbles in DNA: Twist matters

    Science.gov (United States)

    Dasanna, Anil Kumar; Destainville, Nicolas; Palmeri, John; Manghi, Manoel

    2013-05-01

    The closure of long equilibrated denaturation bubbles in DNA is studied using Brownian dynamics simulations. A minimal mesoscopic model is used where the double helix is made of two interacting bead-spring freely rotating strands, with a nonzero torsional modulus in the duplex state, κϕ=200 to 300kBT. For DNAs of lengths N=40 to 100 base pairs (bps) with a large initial bubble in their middle, long closure times of 0.1 to 100μs are found. The bubble starts winding from both ends until it reaches a ≈10 bp metastable state due to the large elastic energy stored in the bubble. The final closure is limited by three competing mechanisms depending on κϕ and N: arms diffusion until their alignment, bubble diffusion along the DNA until one end is reached, or local Kramers process (crossing over a torsional energy barrier). For clamped ends or long DNAs, the closure occurs via this last temperature-activated mechanism, yielding a good quantitative agreement with the experiments.

  17. Review on improved seismic imaging with closure phase

    KAUST Repository

    Schuster, Gerard T.

    2014-08-13

    The timing and amplitudes of arrivals recorded in seismic traces are influenced by velocity variations all along the associated raypaths. Consequently, velocity errors far from the target can lead to blurred imaging of the target body. To partly remedy this problem, we comprehensively reviewed inverting differential traveltimes that satisfied the closure-phase condition. The result is that the source and receiver statics are completely eliminated in the data and velocities far from the target do not need to be known. We successfully used the phase closure equation for traveltime tomography, refraction statics, migration, refraction tomography, and earthquake location, all of which demonstrated the higher resolution achievable by processing data with differential traveltimes rather than absolute traveltimes. More generally, the stationary version of the closure-phase equation is equivalent to Fermat’s principle and can be derived from the equations of seismic interferometry. In summary, the general closure-phase equation is the mathematical foundation for approximately redatuming sources and/or receivers to the target of interest without the need to accurately know the statics or the velocity model away from the target.

  18. 3718-F Alkali Metal Treatment and Storage Facility Closure Plan

    International Nuclear Information System (INIS)

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, as well as for activities associated with nuclear energy development. The 300 Area of the Hanford Site contains reactor fuel manufacturing facilities and several research and development laboratories. The 3718-F Alkali Metal Treatment and Storage Facility (3718-F Facility), located in the 300 Area, was used to store and treat alkali metal wastes. Therefore, it is subject to the regulatory requirements for the storage and treatment of dangerous wastes. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610 (Ecology 1989) and 40 CFR 270.1. Closure also will satisfy the thermal treatment facility closure requirements of 40 CFR 265.381. This closure plan presents a description of the 3718-F Facility, the history of wastes managed, and the approach that will be followed to close the facility. Only hazardous constituents derived from 3718-F Facility operations will be addressed

  19. A Physically Motivated Closure Scheme for Radiative Transfer

    CERN Document Server

    Chan, Chi-kwan

    2009-01-01

    Radiative transfer and radiation hydrodynamics use the relativistic Boltzmann equation to describe the kinetics of photons. The six-dimensional time-dependent transfer equation is difficult to solve unless the problem is in equilibrium or highly symmetric. When the radiation field is smooth, it is natural to take angular moments of the transfer equation to reduce the degrees of freedom. However, low-order moment equations contain terms that depend on higher-order moments. To close the system of moment equations, approximations are made to truncate this hierarchy. Popular closures used in astrophysics include flux limited diffusion and the M_1 closure, which are rather ad hoc and do not necessarily to capture the correct physics. In this paper, we propose a new closure scheme for radiative transfer. We start from a different perspective and highlight the consistency of a fully relativistic formalism. By employing the fact that photons do not self-interact, we conclude that a physical closure should be linear i...

  20. Complex transitive closure queries on a fragmented graph

    NARCIS (Netherlands)

    Houtsma, Maurice A.W.; Apers, Peter M.G.; Ceri, Stefano; Abiteboul, Serge; Kanellakis, Paris C.

    1990-01-01

    In this paper we study the reformulation of transitive closure queries on a fragmented graph. We split a query into several subqueries, each requiring only a fragment of the graph. We prove this reformulation to be correct for shortest path and bill of material queries. Here we describe the reformul

  1. Burdock fructooligosaccharide induces stomatal closure in Pisum sativum.

    Science.gov (United States)

    Guo, Yanling; Guo, Moran; Zhao, Wenlu; Chen, Kaoshan; Zhang, Pengying

    2013-09-12

    Burdock fructooligosaccharide (BFO) isolated from the root tissue of Arctium lappa is a reserve carbohydrate that can induce resistance against a number of plant diseases. Stomatal closure is a part of plant innate immune response to restrict bacterial invasion. In this study, the effects of BFO on stomata movement in Pisum sativum and the possible mechanisms were studied with abscisic acid (ABA) as a positive control. The results showed that BFO could induce stomatal closure accompanied by ROS and NO production, as is the case with ABA. BFO-induced stomatal closure was inhibited by pre-treatment with L-NAME (N(G)-nitro-L-arginine methyl ester, hydrochloride; nitric oxide synthase inhibitor) and catalase (hydrogen peroxide scavenger). Exogenous catalase completely restricted BFO-induced production of ROS and NO in guard cells. In contrast, L-NAME prevented the rise in NO levels but only partially restricted the ROS production. These results indicate that BFO-induced stomatal closure is mediated by ROS and ROS-dependent NO production. PMID:23911508

  2. MCO closure welding process parameter development and qualification

    International Nuclear Information System (INIS)

    One of the key elements in the SNF process is final closure of the MCO by welding. Fuel is loaded into the MCO (approximately 2 ft. in diameter and 13 ft. long) and a heavy shield plug is inserted into the top, creating a mechanical seal. The plug contains several process ports for various operations, including vacuum drying and inert-gas backfilling of the packaged fuel. When fully processed, the Canister Cover Assembly (CCA) is placed over the shield plug and final closure made by welding. The following reports the effort between the Amer Industrial Technology (AIT) and Fluor Hanford (FH) to develop and qualify the welding process for making the final closure--with primary emphasis on developing a set of robust parameters for deposition of the root pass. Work was carried out in three phases: (1) Initial welding process and equipment selection with subsequent field demonstration testing; (2) Development and qualification of a specific process technique and parameters; and (3) Validation of the process and parameters at the CSB under mock production conditions. This work establishes the process technique and parameters that provide a high level of confidence that acceptable MCO closure welds will be made on a consistent and repeatable basis

  3. 40 CFR 265.112 - Closure plan; amendment of plan.

    Science.gov (United States)

    2010-07-01

    ... closure plan must include, at least: (1) A description of how each hazardous waste management unit at the....112 Section 265.112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... to provisions of this section, the owner or operator of a hazardous waste management facility...

  4. Effective closure temperature in leaky and/or saturating thermochronometers

    DEFF Research Database (Denmark)

    Guralnik, Benny; Jain, Mayank; Herman, Frédéric;

    2013-01-01

    approximation for a broad range of cooling functions in systems where closure occurs close to the systemʼs initial/final thermal boundary conditions. We clarify the use and the meaning of TC(T0,TP) by drawing a comparison between (i) a hypothetical application of apatite U–Pb dating (TC≈450°C) on Venus (mean...

  5. An Indian perspective on primary angle closure and glaucoma

    Directory of Open Access Journals (Sweden)

    Sihota Ramanjit

    2011-12-01

    Full Text Available Aim: To provide a synopsis of primary angle closure disease in India, and Indian studies on the same. Results: Primary angle closure glaucoma forms almost half of all adult primary glaucomas seen in a hospital setting in India. Anatomically, corneal diameters and anterior chamber depths were least in acute and chronic PACG eyes as compared to subacute eyes and controls. Besides relative pupillary block, a Valsalva maneuver during activities of daily living may be responsible for intermittent angle closure and raised IOP in predisposed eyes. Iridotomy alone, controlled the intraocular pressure in 66.7% of subacute eyes and 12.9% of the acute. Medical therapy was additionally required for 35.5% of the acute eyes, 12.1% of the subacute and 30.0% of the chronic cases. There was a greater mean and peak IOP reduction, achieved with 0.005% latanoprost once daily, 8.2 ± 2.0 mm Hg, compared with 0.5% timolol twice daily, 6.1 ± 1.7 mm Hg2. A progression of PACS to PAC was seen in 22%, PAC to PAC OHT in 38.7% and PAC OHT to PACG in 30.7% over 5 years. Conclusions: Primary angle closure disease is common in India, and can be managed well with iridotomy, followed by an appropriate control of IOP.

  6. Outcomes of Staple Closure of the Donor Area During Hair Transplant by Follicular Unit Transfer

    OpenAIRE

    Kumaresan Muthuvel; Sornakumar Lakshmikanthan; Deepa Subburathinam

    2014-01-01

    Background: Donor area closure in hair transplantation by follicular unit transfer (FUT) is being done by various techniques. This study aims to assess the outcomes of staple closure for donor area in FUT. Aim: To study the outcome, efficacy and complications of staples in donor area closure for FUT. Materials and Methods: A total of 50 consecutive patients who underwent staple closure for donor area in FUT were included in the study and their data were collected retrospectively. Patients wer...

  7. A short summary on finite element modelling of fatigue crack closure

    International Nuclear Information System (INIS)

    This paper presents a short summary pertaining to the finite element modelling of fatigue crack closure. Several key issues related to finite element modelling of fatigue crack closure are highlighted: element type, mesh refinement, stabilization of crack closure, crack-tip node release scheme, constitutive model, specimen geometry, stress-states (i.e., plane stress, plane strain), crack closure monitoring. Reviews are presented for both straight and deflected cracks

  8. Mine closure : a contingency plan to mitigate socio-economic disasters / Maria Elizabeth Ackermann

    OpenAIRE

    Ackermann, Maria Elizabeth

    2013-01-01

    The history of the mining industry indicates a lack of understanding among the decision-makers of the impact the closure of mines has on the industry and the associated effects on the society and surrounding environment. The policies of the mining industry do make provision for a planned mine closure, but not for an unexpected closure. This detrimental aspect of closures in the mining industry is highlighted in the present study. The present study investigates how mineworkers’ dependency o...

  9. Middle Miocene closure of the Central American Seaway

    Science.gov (United States)

    Montes, C.; Cardona, A.

    2014-12-01

    The final closure of the Panama Isthmus and permanent separation of Caribbean and Pacific waters is thought to have modified their salinity, faunistic assemblages, and ultimately, ocean circulation patterns and global climate. The Great American Biotic Interchange (GABI) is thought to have been the result of Plio-Pleistocene closure of the Isthmus that allowed land animals to massively cross the Isthmus. Similarly, the separation of Caribbean and Pacific waters by a rising Isthmus is thougth to be a prime example of vicariance. The role of Isthmus closure on global changes, however, remains controversial due in part to the difficulty of establishing a precise chronology of seaway closure. While timing of glaciation is well established, new data on the chronology of Isthmus emergence suggests that the process of closure is more complex, long, and old than previously thought. We sampled fluvial and shallow marine strata in northwesternmost South America to recover zircon grains for provenance analyses in the immediate vicinity of the docking site. Because the ages of magmatic provinces in northwestern South America and the Panama Isthmus are mutually exclusive, detrital zircon analyses provides a tool to evaluate land connections. We found that an uniquely Panamanian, 40-45 Ma (early Lutetian) detrital zircon fingerprint is abundant in middle Miocene strata, but absent in underlying lower Miocene and Oligocene strata of the northern Andes. This fingerprint represents the beginning of fluvial detrital exchange between the Panama arc and South America, and therefore marks the time of docking and the end of deep-water, and probably shallow-water connections by middle Miocene times.

  10. ICPP tank farm closure study. Volume 2: Engineering design files

    International Nuclear Information System (INIS)

    Volume 2 contains the following topical sections: Tank farm heel flushing/pH adjustment; Grouting experiments for immobilization of tank farm heel; Savannah River high level waste tank 20 closure; Tank farm closure information; Clean closure of tank farm; Remediation issues; Remote demolition techniques; Decision concerning EIS for debris treatment facility; CERCLA/RCRA issues; Area of contamination determination; Containment building of debris treatment facility; Double containment issues; Characterization costs; Packaging and disposal options for the waste resulting from the total removal of the tank farm; Take-off calculations for the total removal of soils and structures at the tank farm; Vessel off-gas systems; Jet-grouted polymer and subsurface walls; Exposure calculations for total removal of tank farm; Recommended instrumentation during retrieval operations; High level waste tank concrete encasement evaluation; Recommended heavy equipment and sizing equipment for total removal activities; Tank buoyancy constraints; Grout and concrete formulas for tank heel solidification; Tank heel pH requirements; Tank cooling water; Evaluation of conservatism of vehicle loading on vaults; Typical vault dimensions and approximately tank and vault void volumes; Radiological concerns for temporary vessel off-gas system; Flushing calculations for tank heels; Grout lift depth analysis; Decontamination solution for waste transfer piping; Grout lift determination for filling tank and vault voids; sprung structure vendor data; Grout flow properties through a 2--4 inch pipe; Tank farm load limitations; NRC low level waste grout; Project data sheet calculations; Dose rates for tank farm closure tasks; Exposure and shielding calculations for grout lines; TFF radionuclide release rates; Documentation of the clean closure of a system with listed waste discharge; and Documentation of the ORNL method of radionuclide concentrations in tanks

  11. Waste Encapsulation and Storage Facility (WESF) Interim Status Closure Plan

    International Nuclear Information System (INIS)

    This document describes the planned activities and performance standards for closing the Waste Encapsulation and Storage Facility (WESF). WESF is located within the 225B Facility in the 200 East Area on the Hanford Facility. Although this document is prepared based on Title 40 Code of Federal Regulations (CFR), Part 265, Subpart G requirements, closure of the storage unit will comply with Washington Administrative Code (WAC) 173-303-610 regulations pursuant to Section 5.3 of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) Action Plan (Ecology et al. 1996). Because the intention is to clean close WESF, postclosure activities are not applicable to this interim status closure plan. To clean close the storage unit, it will be demonstrated that dangerous waste has not been left onsite at levels above the closure performance standard for removal and decontamination. If it is determined that clean closure is not possible or environmentally is impracticable, the interim status closure plan will be modified to address required postclosure activities. WESF stores cesium and strontium encapsulated salts. The encapsulated salts are stored in the pool cells or process cells located within 225B Facility. The dangerous waste is contained within a double containment system to preclude spills to the environment. In the unlikely event that a waste spill does occur outside the capsules, operating methods and administrative controls require that waste spills be cleaned up promptly and completely, and a notation made in the operating record. Because dangerous waste does not include source, special nuclear, and by-product material components of mixed waste, radionuclides are not within the scope of this documentation. The information on radionuclides is provided only for general knowledge

  12. ICPP tank farm closure study. Volume 2: Engineering design files

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    Volume 2 contains the following topical sections: Tank farm heel flushing/pH adjustment; Grouting experiments for immobilization of tank farm heel; Savannah River high level waste tank 20 closure; Tank farm closure information; Clean closure of tank farm; Remediation issues; Remote demolition techniques; Decision concerning EIS for debris treatment facility; CERCLA/RCRA issues; Area of contamination determination; Containment building of debris treatment facility; Double containment issues; Characterization costs; Packaging and disposal options for the waste resulting from the total removal of the tank farm; Take-off calculations for the total removal of soils and structures at the tank farm; Vessel off-gas systems; Jet-grouted polymer and subsurface walls; Exposure calculations for total removal of tank farm; Recommended instrumentation during retrieval operations; High level waste tank concrete encasement evaluation; Recommended heavy equipment and sizing equipment for total removal activities; Tank buoyancy constraints; Grout and concrete formulas for tank heel solidification; Tank heel pH requirements; Tank cooling water; Evaluation of conservatism of vehicle loading on vaults; Typical vault dimensions and approximately tank and vault void volumes; Radiological concerns for temporary vessel off-gas system; Flushing calculations for tank heels; Grout lift depth analysis; Decontamination solution for waste transfer piping; Grout lift determination for filling tank and vault voids; sprung structure vendor data; Grout flow properties through a 2--4 inch pipe; Tank farm load limitations; NRC low level waste grout; Project data sheet calculations; Dose rates for tank farm closure tasks; Exposure and shielding calculations for grout lines; TFF radionuclide release rates; Documentation of the clean closure of a system with listed waste discharge; and Documentation of the ORNL method of radionuclide concentrations in tanks.

  13. EARLY ILEOSTOMY CLOSURE FOLLOWING EMERGENCY BOWEL SURGERY: A FEASIBLE APPROACH

    Directory of Open Access Journals (Sweden)

    Nitin

    2014-05-01

    Full Text Available BACKGROUND: Ileostomy is often constructed in emergency surgical conditions like enteric or tubercular perforations when patients present late in the course of illness to preclude primary closure. But the ileostomy carries with it lot of morbidity making the quality of life poor. The early closure of ileostomy can minimize the associated morbidity and help the patient to enjoy better quality of life sooner. METHODOLOGY: In this retrospective study, hospital data was collected between November 2010 and October 2013, of the patients whose ileostomy was closed within 3-6 weeks from the time of initial surgery. Demographic, operative and complication data were recorded and reviewed as to the final post-operative outcome. RESULTS: Total 22 patients were taken up for ileostomy closure between 3-6 weeks with the mean of 33.6 days. Stoma related complications occurred in 22.7% of patients, skin excoriation being the commonest (13.6%. No difficulty was encountered during stoma closure surgery. Post-op complications occurred in 27.3% of patients, and wound infection was the commonest (18.2%. Other complications were paralytic ileus (9.1%, intestinal obstruction (4.5%, and incisional hernia (4.5%. There was no instance of anastomotic leak, intra-abdominal abscess, entero-cutaneous fistula or mortality. CONCLUSION: The present study clearly highlights the potential advantages of early closure of ileostomy without any added morbidity or mortality, and is a feasible alternative to a more conventional delayed approach, provided careful selection of patients is done. This significantly cuts down the convalescence period of the patient and helps him to live a better quality of life much earlier.

  14. 40 CFR 264.144 - Cost estimate for post-closure care.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Cost estimate for post-closure care... FACILITIES Financial Requirements § 264.144 Cost estimate for post-closure care. (a) The owner or operator of.... (1) The post-closure cost estimate must be based on the costs to the owner or operator of hiring...

  15. 40 CFR 265.144 - Cost estimate for post-closure care.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Cost estimate for post-closure care..., STORAGE, AND DISPOSAL FACILITIES Financial Requirements § 265.144 Cost estimate for post-closure care. (a....280, and 265.310. (1) The post-closure cost estimate must be based on the costs to the owner...

  16. 40 CFR 146.73 - Financial responsibility for post-closure care.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Financial responsibility for post-closure care. 146.73 Section 146.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... closure and post-closure care in 40 CFR part 144, subpart F. The amount of the funds available shall be...

  17. Moment closures based on minimizing the residual of the PN angular expansion in radiation transport

    Science.gov (United States)

    Zheng, Weixiong; McClarren, Ryan G.

    2016-06-01

    In this work we present two new closures for the spherical harmonics (PN) method in slab geometry transport problems. Our approach begins with an analysis of the squared-residual of the transport equation where we show that the standard truncation and diffusive closures do not minimize the residual of the PN expansion. Based on this analysis we derive two models, a moment-limited diffusive (ML DN) closure and a transient PN (TPN) closure that attempt to address shortcomings of common closures. The form of these closures is similar to flux-limiters for diffusion with the addition of a time-derivative in the definition of the closure. Numerical results on a pulsed plane source problem, the Gordian knot of slab-geometry transport problems, indicate that our new closure outperforms existing linear closures. Additionally, on a deep penetration problem we demonstrate that the TPN closure does not suffer from the artificial shocks that can arise in the MN entropy-based closure. Finally, results for Reed's problem demonstrate that the TPN solution is as accurate as the PN+3 solution. We further extend the TPN closure to 2D Cartesian geometry. The line source test problem demonstrates the model effectively damps oscillations and negative densities.

  18. A Surface Temperature Initiated Closure (STIC) for surface energy balance fluxes

    DEFF Research Database (Denmark)

    Mallick, Kaniska; Jarvis, Andrew J.; Boegh, Eva;

    2014-01-01

    method combines satellite TS data with standard energy balance closure models in order to derive a hybrid closure that does not require the specification of surface to atmosphere conductance terms. We call this the Surface Temperature Initiated Closure (STIC), which is formed by the simultaneous solution...

  19. Project Management Approach to Transition of the Miamisburg Closure Project From Environmental Cleanup to Post-Closure Operations

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) used a project management approach to transition the Miamisburg Closure Project from cleanup by the Office of Environmental Management (EM) to post-closure operations by the Office of Legacy Management (LM). Two primary DOE orders were used to guide the site transition: DOE Order 430.1B, Real Property Asset Management, for assessment and disposition of real property assets and DOE Order 413.3, Program and Project Management for Acquisition of Capital Assets, for project closeout of environmental cleanup activities and project transition of post-closure activities. To effectively manage these multiple policy requirements, DOE chose to manage the Miamisburg Closure Project as a project under a cross-member transitional team using representatives from four principal organizations: DOE-LM, the LM contractor S.M. Stoller Corporation, DOE-EM, and the EM contractor CH2M Hill Mound Inc. The mission of LM is to manage the Department's post-transition responsibilities and long-term care of legacy liabilities and to ensure the future protection of human health and the environment for cleanup sites after the EM has completed its cleanup activities. (authors)

  20. Single loop-and-clips technique (KING closure) for gastrotomy closure after transgastric ovariectomy: a survival experiment

    Czech Academy of Sciences Publication Activity Database

    Ryska, O.; Martinek, J.; Filípková, T.; Doležel, R.; Juhásová, Jana; Motlík, Jan; Zavoral, M.; Ryska, M.

    2012-01-01

    Roč. 7, č. 4 (2012), s. 233-239. ISSN 1895-4588 R&D Projects: GA MZd NS9994 Institutional research plan: CEZ:AV0Z50450515 Keywords : natural orifice transluminal endoscopic surgery * gastric closure * clips * endoloop Subject RIV: FJ - Surgery incl. Transplants Impact factor: 0.757, year: 2012

  1. Mechanosensitive ion channels

    Directory of Open Access Journals (Sweden)

    Ken Takahashi

    2016-01-01

    Full Text Available Cell surface receptors are involved in numerous important biological processes including embryogenesis, tissue differentiation, and cellular homeostasis. Among them, mechanosensitive ion channels play an essential role in cellular functions of every cell including neurons, cardiomyocytes, and osteocytes. Here, we discuss types, roles, structures, and biophysical factors that affect the functions of mechanosensitive ion channels.

  2. RFI channels, 2

    Science.gov (United States)

    Mceliece, R. J.

    1981-01-01

    The cutoff parameters for a class of channel models exhibiting burst noise behavior were calculated and the performance of interleaved coding strategies was evaluated. It is concluded that, provided the channel memory is large enough and is properly exploited, interleaved coding is nearly optimal.

  3. Antiapoptotic Effect of Simvastatin Ameliorates Myocardial Ischemia/Reperfusion Injury

    Science.gov (United States)

    Hadi, Najah R.; Al-amran, Fadhil; Yousif, Maitham; Zamil, Suhaad T.

    2013-01-01

    Background. Myocardial ischemial reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty, and coronary bypass surgery. Injury of myocardium due to ischemial reperfusion includes cardiac contractile dysfunction, arrhythmias, and irreversible myocytes damage. These changes are considered to be the consequence of imbalance between the formation of oxidants and the availability of endogenous antioxidants in the heart. Objective. This study was undertaken to investigate the potential role of Simvastatin in the amelioration of myocardial I/R injury induced by ligation of coronary artery in a rat model. Materials and Methods. Adult male Swiss Albino rats were randomized into 4 equal groups. Group (1): sham group: rats underwent the same anesthetic and surgical procedures as those in the control group except ligation of LAD coronary artery, group (2): control group: rats were subjected to regional ischemia for 25 min and reperfusion for 2 hours by ligation of LAD coronary artery, group (3): control vehicle group: rats received vehicle of Simvastatin (normal saline) via IP injection and were subjected to regional ischemia for 25 min and reperfusion for 2 hours by ligation of LAD coronary artery, group (4): Simvastatin treated group: rats were pretreated with Simvastatin 1 mg/kg i.p. 1 hr before ligation of LAD coronary artery. At the end of experiment (2 hr of reperfusion), blood samples were collected from the heart for the measurement of plasma level of cardiac troponin I (cTnI). After that the heart was harvested and divided into 3 parts; one part was used for measurement of apoptosis, another part was homogenized for the measurement of tissue tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α, and the last part for histopathology study. Results. Compared with the sham group, levels of myocardial TNF-α and IL-1β, IL-6

  4. PEG minocycline-liposomes ameliorate CNS autoimmune disease.

    Directory of Open Access Journals (Sweden)

    Wei Hu

    Full Text Available BACKGROUND: Minocycline is an oral tetracycline derivative with good bioavailability in the central nervous system (CNS. Minocycline, a potent inhibitor of matrix metalloproteinase (MMP-9, attenuates disease activity in experimental autoimmune encephalomyelitis (EAE, an animal model of multiple sclerosis (MS. Potential adverse effects associated with long-term daily minocycline therapy in human patients are concerning. Here, we investigated whether less frequent treatment with long-circulating polyethylene glycol (PEG minocycline liposomes are effective in treating EAE. FINDINGS: Performing in vitro time kinetic studies of PEG minocycline-liposomes in human peripheral blood mononuclear cells (PBMCs, we determined that PEG minocycline-liposome preparations stabilized with CaCl(2 are effective in diminishing MMP-9 activity. Intravenous injections of PEG minocycline-liposomes every five days were as effective in ameliorating clinical EAE as daily intraperitoneal injections of minocycline. Treatment of animals with PEG minocycline-liposomes significantly reduced the number of CNS-infiltrating leukocytes, and the overall expression of MMP-9 in the CNS. There was also a significant suppression of MMP-9 expression and proteolytic activity in splenocytes of treated animals, but not in CNS-infiltrating leukocytes. Thus, leukocytes gaining access to the brain and spinal cord require the same absolute amount of MMP-9 in all treatment groups, but minocycline decreases the absolute cell number. CONCLUSIONS: Our data indicate that less frequent injections of PEG minocycline-liposomes are an effective alternative pharmacotherapy to daily minocycline injections for the treatment of CNS autoimmune diseases. Also, inhibition of MMP-9 remains a promising treatment target in EAE and patients with MS.

  5. Matrine ameliorates spontaneously developed colitis in interleukin-10-deficient mice.

    Science.gov (United States)

    Wu, Cong; Xu, Zheng; Gai, Renhua; Huang, Kehe

    2016-07-01

    Interleukin-10 (IL-10)-deficient mice spontaneously develop T cell-mediated colitis. Previous reports have shown that Matrine may reduce the symptoms of acute colitis induced by trinitrobenzene sulfonic acid (TNBS). However, whether Matrine impacts chronic colitis remains unknown. In this study, we investigated whether Matrine could limit the symptoms of spontaneously developed colitis and its potential molecular mechanisms. IL-10 deficient mice were given Matrine or a PBS control by oral gavage daily for 4weeks and were euthanized at week 2 or week 4. We measured body weight, colon length and weight, and histological scores. We also evaluated the spontaneous secretion of IL-12/23p40, IFN-γ and IL-17 in colon explant cultures as well as IFN-γ and IL-17 secretion in unseparated mesenteric lymph node (MLN) cells, and assessed IFN-γ, IL-17, IL-1β and IL-6 mRNA expression in colon tissue. In addition, we analyzed the proportions of CD4-positive and CD8-positive cells in unseparated MLN cells. Our results show that Matrine-treated mice exhibited better body weight recovery than controls and that histological scores and spontaneously secreted IL-12/23p40, IFN-γ and IL-17 in colon tissue were significantly decreased in treated mice compared with controls. The proportion of CD4-positive cells of MLNs in treated mice was significantly smaller than that in controls at week 4. Both cytokine production and mRNA expression of IFN-γ and IL-17 were significantly reduced in treated mice compared with controls. Taken together, our results indicate that Matrine may ameliorate spontaneously developed chronic colitis and could be considered as a therapeutic alternative for chronic colitis. PMID:27179305

  6. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia.

    Science.gov (United States)

    Fernández-Murray, J Pedro; Prykhozhij, Sergey V; Dufay, J Noelia; Steele, Shelby L; Gaston, Daniel; Nasrallah, Gheyath K; Coombs, Andrew J; Liwski, Robert S; Fernandez, Conrad V; Berman, Jason N; McMaster, Christopher R

    2016-01-01

    Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell precursors. A common subtype of congenital sideroblastic anemia is due to autosomal recessive mutations in the SLC25A38 gene. The current treatment for SLC25A38 congenital sideroblastic anemia is chronic blood transfusion coupled with iron chelation. The function of SLC25A38 is not known. Here we report that the SLC25A38 protein, and its yeast homolog Hem25, are mitochondrial glycine transporters required for the initiation of heme synthesis. To do so, we took advantage of the fact that mitochondrial glycine has several roles beyond the synthesis of heme, including the synthesis of folate derivatives through the glycine cleavage system. The data were consistent with Hem25 not being the sole mitochondrial glycine importer, and we identify a second SLC25 family member Ymc1, as a potential secondary mitochondrial glycine importer. Based on these findings, we observed that high levels of exogenous glycine, or 5-aminolevulinic acid (5-Ala) a metabolite downstream of Hem25 in heme biosynthetic pathway, were able to restore heme levels to normal in yeast cells lacking Hem25 function. While neither glycine nor 5-Ala could ameliorate SLC25A38 congenital sideroblastic anemia in a zebrafish model, we determined that the addition of folate with glycine was able to restore hemoglobin levels. This difference is likely due to the fact that yeast can synthesize folate, whereas in zebrafish folate is an essential vitamin that must be obtained exogenously. Given the tolerability of glycine and folate in humans, this study points to a potential novel treatment for SLC25A38 congenital sideroblastic anemia. PMID:26821380

  7. NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.

    Directory of Open Access Journals (Sweden)

    Michelle F Goody

    Full Text Available Muscular dystrophies are common, currently incurable diseases. A subset of dystrophies result from genetic disruptions in complexes that attach muscle fibers to their surrounding extracellular matrix microenvironment. Cell-matrix adhesions are exquisite sensors of physiological conditions and mediate responses that allow cells to adapt to changing conditions. Thus, one approach towards finding targets for future therapeutic applications is to identify cell adhesion pathways that mediate these dynamic, adaptive responses in vivo. We find that nicotinamide riboside kinase 2b-mediated NAD+ biosynthesis, which functions as a small molecule agonist of muscle fiber-extracellular matrix adhesion, corrects dystrophic phenotypes in zebrafish lacking either a primary component of the dystrophin-glycoprotein complex or integrin alpha7. Exogenous NAD+ or a vitamin precursor to NAD+ reduces muscle fiber degeneration and results in significantly faster escape responses in dystrophic embryos. Overexpression of paxillin, a cell adhesion protein downstream of NAD+ in this novel cell adhesion pathway, reduces muscle degeneration in zebrafish with intact integrin receptors but does not improve motility. Activation of this pathway significantly increases organization of laminin, a major component of the extracellular matrix basement membrane. Our results indicate that the primary protective effects of NAD+ result from changes to the basement membrane, as a wild-type basement membrane is sufficient to increase resilience of dystrophic muscle fibers to damage. The surprising result that NAD+ supplementation ameliorates dystrophy in dystrophin-glycoprotein complex- or integrin alpha7-deficient zebrafish suggests the existence of an additional laminin receptor complex that anchors muscle fibers to the basement membrane. We find that integrin alpha6 participates in this pathway, but either integrin alpha7 or the dystrophin-glycoprotein complex is required in conjunction

  8. Black Cohosh Ameliorates Metabolic Disorders in Female Ovariectomized Rats.

    Science.gov (United States)

    Sun, Yu; Yu, Qiuxiao; Shen, Qiyang; Bai, Wenpei; Kang, Jihong

    2016-06-01

    Estrogen deficiency is associated with metabolic derangements in menopausal women. Black cohosh has been widely used as an alternative therapy in the treatment of menopausal syndrome. However, its role in metabolism needs to be defined. The aim of the present study was to investigate the long-term effect of black cohosh on glucose and lipid metabolism in a rat model of post-menopause. Adult female Sprague-Dawley rats were sham operated (SHAM), ovariectomized (OVX), OVX with the treatment of estradiol valerate (OVX + E), or OVX with the treatment of isopropanolic black cohosh extract (OVX + iCR). Body weight, body composition, and blood glucose levels of the animals were monitored. The rats were then sacrificed after 3 months of the treatments. At the end of the experiment, OVX + iCR and OVX + E rats exhibited a significant decrease in body weight gain, body and abdominal fat mass, serum triglycerides levels, hepatic fat accumulation, and adipocyte hypertrophy compared with OVX rats. In addition, insulin resistance and glucose intolerance were improved in OVX + iCR but not in OVX + E rats. No hepatotoxicity was detected in OVX + iCR animals. Furthermore, western blot analysis suggested the increased lipolysis in adipose tissue of OVX + iCR and OVX + E rats. Data from in vitro experiments using cultured primary rat adipocytes also showed that black cohosh could affect lipolysis of adipocytes. In conclusion, the long-term treatment of black cohosh at a proper dosage ameliorated metabolic derangements in OVX rats. Thus, this drug is promising for the treatment of metabolic disorders in menopausal and post-menopausal women. PMID:26414761

  9. Promoterless gene targeting without nucleases ameliorates haemophilia B in mice.

    Science.gov (United States)

    Barzel, A; Paulk, N K; Shi, Y; Huang, Y; Chu, K; Zhang, F; Valdmanis, P N; Spector, L P; Porteus, M H; Gaensler, K M; Kay, M A

    2015-01-15

    Site-specific gene addition can allow stable transgene expression for gene therapy. When possible, this is preferred over the use of promiscuously integrating vectors, which are sometimes associated with clonal expansion and oncogenesis. Site-specific endonucleases that can induce high rates of targeted genome editing are finding increasing applications in biological discovery and gene therapy. However, two safety concerns persist: endonuclease-associated adverse effects, both on-target and off-target; and oncogene activation caused by promoter integration, even without nucleases. Here we perform recombinant adeno-associated virus (rAAV)-mediated promoterless gene targeting without nucleases and demonstrate amelioration of the bleeding diathesis in haemophilia B mice. In particular, we target a promoterless human coagulation factor IX (F9) gene to the liver-expressed mouse albumin (Alb) locus. F9 is targeted, along with a preceding 2A-peptide coding sequence, to be integrated just upstream to the Alb stop codon. While F9 is fused to Alb at the DNA and RNA levels, two separate proteins are synthesized by way of ribosomal skipping. Thus, F9 expression is linked to robust hepatic albumin expression without disrupting it. We injected an AAV8-F9 vector into neonatal and adult mice and achieved on-target integration into ∼0.5% of the albumin alleles in hepatocytes. We established that F9 was produced only from on-target integration, and ribosomal skipping was highly efficient. Stable F9 plasma levels at 7-20% of normal were obtained, and treated F9-deficient mice had normal coagulation times. In conclusion, transgene integration as a 2A-fusion to a highly expressed endogenous gene may obviate the requirement for nucleases and/or vector-borne promoters. This method may allow for safe and efficacious gene targeting in both infants and adults by greatly diminishing off-target effects while still providing therapeutic levels of expression from integration. PMID:25363772

  10. Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats

    Directory of Open Access Journals (Sweden)

    Xianchu Liu

    2016-04-01

    Full Text Available Objective(s:Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (STZ-induced diabetic rats. Recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. However, to date, no studies have investigated the ameliorative effects of naringin on diabetes-associated cognitive decline (DACD. In this study, we investigated the effects of naringin, using a STZ-injected rat model and explored its potential mechanism. Materials and Methods:Diabetic rats were treated with naringin (100 mg/kg/d for 7 days. The learning and memory function were assessed by Morris water maze test. The oxidative stress indicators [superoxide dismutase (SOD and malondialdehyde (MDA] and inflammatory cytokines (TNF-a, IL-1β, and IL-6 were measured in hippocampus using corresponding commercial kits. The mRNA and protein levels of PPARγ were evaluated by real time (RT-PCR and Western blot analysis. Results:The results showed that supplementation of naringin improved learning and memory performances compared with the STZ group. Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-α, IL-1β, and IL-6 compared with the STZ group in the hippocampus. The pretreatment with naringin also significantly increased PPARγ expression. Conclusion: Our results showed that naringin may be a promising therapeutic agent for improving cognitive decline in DACD.

  11. Amelioration of radiation damage by pentoxifylline treatment in rats

    International Nuclear Information System (INIS)

    Pentoxifylline (PTX) is a methylxanthine derivative used to treat vascular diseases. It has antioxidant properties, an anti- tumour necrosis factor alpha (TNFα) effect, increase erythrocyte flexibility and vasodilatation. An agent that increases blood flow and tissue oxygen content may contribute to enhanced healing of soft tissue, and inhibit inflammatory reactions. The mechanism of action of the anti-oxidant effect of pentoxifylline is not yet clear and it is an interesting field to explore. This study has investigated the antioxidant pathways through which PTX treatment (1200 mg/ l in drinking water) exerts its effect on radiation-induced changes. Blood reduced glutathione (GSH), glutathione peroxidase (GSH-PX) and serum catalase (CAT), MDA, xanthine oxidase (XO) and xanthine dehydrogenase (XDH), total protein, albumin, uric acid, advanced oxidation protein products (AOPP) and ascorbyl radical (AsR) were measured in female rats. Animals were divided into: Group 1: control, Group 2: administrated PTX for 8 days. Group 3: Exposed to fractionated radiation at the dose level of 4 Gy (2 Gy every 4 days) for 8 days and Group 4: received PTX two h post the onset of irradiation (4 Gy fractionated) till the end of the experiment. All animals were inspected after 8 days from the beginning of the experiment. Fractionated 4 Gy whole body gamma irradiation induced oxidative damage manifested in the significant decreases in blood GSH content, GSH-PX and CAT activities, total protein, albumin, uric acid, and XDH. Conversely, significant elevations were detected in plasma MDA, AOPP and AsR contents as well as XO activity. PTX treatment ameliorated radiation induced oxidative damage through its antioxidant properties and free radical scavenging ability that is partially mediated through inhibition of xanthine oxidase thus could play a role in regulating radiation complications.

  12. Channelling versus inversion

    DEFF Research Database (Denmark)

    Gale, A.S.; Surlyk, Finn; Anderskouv, Kresten

    2013-01-01

    . Within this channel were smaller erosional structures (<10 m deep) that truncate originally horizontal bedding, are floored by hardgrounds, and locally have a basal fill of granular phosphorite. The entire channel system was progressively infilled by chalk, as demonstrated by the expanded succession of...... the lower Campanian Culver Chalk Formation. The beds of the channel fill are cut by small step faults, resulting from gravitational collapse. Complete burial had taken place by the base of the upper Campanian Portsdown Chalk Formation, which is of even thickness across the region. The structures are......Evidence from regional stratigraphical patterns in Santonian−Campanian chalk is used to infer the presence of a very broad channel system (5 km across) with a depth of at least 50 m, running NNW−SSE across the eastern Isle of Wight; only the western part of the channel wall and fill is exposed...

  13. Incompatibility breaking quantum channels

    International Nuclear Information System (INIS)

    A typical bipartite quantum protocol, such as EPR-steering, relies on two quantum features, entanglement of states and incompatibility of measurements. Noise can delete both of these quantum features. In this work we study the behavior of incompatibility under noisy quantum channels. The starting point for our investigation is the observation that compatible measurements cannot become incompatible by the action of any channel. We focus our attention to channels which completely destroy the incompatibility of various relevant sets of measurements. We call such channels incompatibility breaking, in analogy to the concept of entanglement breaking channels. This notion is relevant especially for the understanding of noise-robustness of the local measurement resources for steering. (paper)

  14. Cardiac potassium channel subtypes

    DEFF Research Database (Denmark)

    Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter

    2014-01-01

    About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K(+) channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the cardiac cycle. Three main K(+) channels...... drive the late repolarization of the ventricle with some redundancy, and in atria this repolarization reserve is supplemented by the fairly atrial-specific KV1.5, Kir3, KCa, and K2P channels. The role of the latter two subtypes in atria is currently being clarified, and several findings indicate that...... they could constitute targets for new pharmacological treatment of atrial fibrillation. The interplay between the different K(+) channel subtypes in both atria and ventricle is dynamic, and a significant up- and downregulation occurs in disease states such as atrial fibrillation or heart failure. The...

  15. Athermalized channeled spectropolarimeter enhancement.

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Julia Craven; Way, Brandyn Michael; Mercier, Jeffrey Alan; Hunt, Jeffery P.

    2013-09-01

    Channeled spectropolarimetry can measure the complete polarization state of light as a function of wavelength. Typically, a channeled spectropolarimeter uses high order retarders made of uniaxial crystal to amplitude modulate the measured spectrum with the spectrally-dependent Stokes polarization information. A primary limitation of conventional channeled spectropolarimeters is related to the thermal variability of the retarders. Thermal variation often forces frequent system recalibration, particularly for field deployed systems. However, implementing thermally stable retarders, made of biaxial crystal, results in an athermal channeled spectropolarimeter that relieves the need for frequent recalibration. This report presents experimental results for an anthermalized channeled spectropolarimeter prototype produced using potassium titanyl phosphate. The results of this prototype are compared to the current thermal stabilization state of the art. Finally, the application of the technique to the thermal infrared is studied, and the athermalization concept is applied to an infrared imaging spectropolarimeter design.

  16. Thermally stratified sodium channel flow: turbulence and modeling

    International Nuclear Information System (INIS)

    Numerical simulation of sodium stratification in open channel flow has been studied with Computational Fluid Dynamics (CFD) employing an Algebraic Heat Flux Model (AHFM) closure for the turbulent heat flux. The results are validated against experimental data and the AHFM is compared with the simplified Reynolds analogy employing a constant turbulent Pr number. Influence of buoyancy on turbulence created in the mixing layer has been evaluated and its influence on the momentum and energy transport in the vertical direction assessed. It has been found that the choice of turbulent heat flux model influences the achieved results for temperature and velocity field which might affect the flow developing and persistence of stratification in the channel. Moreover both experiment and validation show the possibility of creation of a strong stratification also for low Pr number fluids, warning the stratification problem as an existing phenomenon likely to occur in liquid metal nuclear power plants. (author)

  17. Effect of Soil Ameliorators on Ectomycorrhizal Fungal Communities that Colonize Seedlings of Pinus densiflora in Abandoned Coal Mine Spoils

    OpenAIRE

    Lee, Eun-Hwa; Eo, Ju-Kyeong; Lee, Chang-Seok; Eom, Ahn-Heum

    2012-01-01

    In this study, the effect of soil ameliorators on ectomycorrhizal (ECM) fungal communities in coal mine spoils was investigated. Organic fertilizers and slaked lime were applied as soil ameliorators in 3 abandoned coal mine spoils. One year after the initial treatment, roots of Pinus densiflora seedlings were collected and the number of ECM species, colonization rate, and species diversity were assessed. The results showed that the soil ameliorators significantly increased ECM colonization on...

  18. Internal stress distribution for generating closure domains in laser-irradiated Fe–3%Si(110) steels

    International Nuclear Information System (INIS)

    Internal stress distribution for generating closure domains occurring in laser-irradiated Fe–3%Si(110) steels was investigated using high-energy X-ray analysis and domain theory based on the variational principle. The measured triaxial stresses inside the specimen were compressive and the stress in the rolling direction became more dominant than stresses in the other directions. The calculations based on the variational principle of magnetic energy for closure domains showed that the measured triaxial stresses made the closure domains more stable than the basic domain without closure domains. The experimental and calculation results reveal that the laser-introduced internal stresses result in the occurrence of the closure domains

  19. Internal stress distribution for generating closure domains in laser-irradiated Fe–3%Si(110) steels

    Energy Technology Data Exchange (ETDEWEB)

    Iwata, Keiji, E-mail: iwata.24h.keiji@jp.nssmc.com [Advanced Technology Research Laboratories, Nippon Steel and Sumitomo Metal Corporation, Futtsu, Chiba 293-8511 (Japan); Research Institute of Electrical Communication, Tohoku University, Aoba, Sendai 980-8577 (Japan); Imafuku, Muneyuki; Orihara, Hideto; Sakai, Yusuke; Ohya, Shin-Ichi [Department of Mechanical Systems Engineering, Tokyo City University, Tokyo, 158-0087 (Japan); Suzuki, Tamaki [Advanced Technology Research Laboratories, Nippon Steel and Sumitomo Metal Corporation, Futtsu, Chiba 293-8511 (Japan); Shobu, Takahisa [Quantum Beam Science Directorate, Japan Atomic Energy Agency, Sayo, Hyogo 679-5148 (Japan); Akita, Koichi [Quantum Beam Science Directorate, Japan Atomic Energy Agency, Naka, Ibaraki 319-1195 (Japan); Ishiyama, Kazushi [Research Institute of Electrical Communication, Tohoku University, Aoba, Sendai 980-8577 (Japan)

    2015-05-07

    Internal stress distribution for generating closure domains occurring in laser-irradiated Fe–3%Si(110) steels was investigated using high-energy X-ray analysis and domain theory based on the variational principle. The measured triaxial stresses inside the specimen were compressive and the stress in the rolling direction became more dominant than stresses in the other directions. The calculations based on the variational principle of magnetic energy for closure domains showed that the measured triaxial stresses made the closure domains more stable than the basic domain without closure domains. The experimental and calculation results reveal that the laser-introduced internal stresses result in the occurrence of the closure domains.

  20. Oxytocin ameliorates the immediate myocardial injury in heart transplant through down regulation of the neutrophil dependent myocardial apoptosis

    Directory of Open Access Journals (Sweden)

    F Fadhil Al-Amran

    2014-01-01

    Conclusion: Oxytocin ameliorates myocardial injury in heart transplant through down-regulation the myocardial inflammatory response, reactive oxygen species, and neutrophil-dependant myocardial apoptosis.

  1. Considerations for closure of low-level radioactive waste engineered disposal facilities

    International Nuclear Information System (INIS)

    Proper stabilization and closure of low-level radioactive waste disposal facilities require detailed planning during the early stages of facility development. This report provides considerations for host States, compact regions, and unaffiliated States on stabilization and closure of engineered low-level radioactive waste and mixed waste disposal facilities. A time line for planning closure activities, which identifies closure considerations to be addressed during various stages of a facility's development, is presented. Current Federal regulatory requirements and guidance for closure and post-closure are outlined. Significant differences between host State and Federal closure requirements are identified. Design features used as stabilization measures that support closure, such as waste forms and containers, backfill materials, engineered barrier systems, and site drainage systems, are described. These design features are identified and evaluated in terms of how they promote long-term site stability by minimizing water infiltration, controlling subsidence and surface erosion, and deterring intrusion. Design and construction features critical to successful closure are presented for covers and site drainage. General considerations for stabilization and closure operations are introduced. The role of performance and environmental monitoring during closure is described

  2. Decontamination and inspection plan for Phase 3 closure of the 300 area waste acid treatment system

    International Nuclear Information System (INIS)

    This decontamination and inspection plan (DIP) describes decontamination and verification activities in support of Phase 3 closure of the 300 Area Waste Acid Treatment System (WATS). Phase 3 is the third phase of three WATS closure phases. Phase 3 attains clean closure conditions for WATS portions of the 334 and 311 Tank Farms (TF) and the 333 and 303-F Buildings. This DIP also describes designation and management of waste and debris generated during Phase 3 closure activities. Information regarding Phase 1 and Phase 2 for decontamination and verification activities closure can be found in WHC-SD-ENV-AP-001 and HNF-1784, respectively. This DIP is provided as a supplement to the closure plan (DOE/RL-90-11). This DIP provides the documentation for Ecology concurrence with Phase 3 closure methods and activities. This DIP is intended to provide greater detail than is contained in the closure plan to satisfy Ecology Dangerous Waste Regulations, Washington Administrative Code (WAC) 173-303-610 requirement that closure documents describe the methods for removing, transporting, storing, and disposing of all dangerous waste at the unit. The decontamination and verification activities described in this DIP are based on the closure plan and on agreements reached between Ecology and the U.S. Department of Energy, Richland Operations Office (DOE-RL) during Phase 3 closure activity workshops and/or project manager meetings (PMMs)

  3. Ion channel screening.

    Science.gov (United States)

    Dunlop, John; Bowlby, Mark; Peri, Ravikumar; Tawa, Gregory; LaRocque, James; Soloveva, Veronica; Morin, John

    2008-08-01

    Ion channels are attractive targets for drug discovery with recent estimates indicating that voltage and ligand-gated channels account for the third and fourth largest gene families represented in company portfolios after the G protein coupled and nuclear hormone receptor families. A historical limitation on ion channel targeted drug discovery in the form of the extremely low throughput nature of the gold standard assay for assessing functional activity, patch clamp electrophysiology in mammalian cells, has been overcome by the implementation of multi-well plate format cell-based screening strategies for ion channels. These have taken advantage of various approaches to monitor ion flux or membrane potential using radioactive, non-radioactive, spectroscopic and fluorescence measurements and have significantly impacted both high-throughput screening and lead optimization efforts. In addition, major advances have been made in the development of automated electrophysiological platforms to increase capacity for cell-based screening using formats aimed at recapitulating the gold standard assay. This review addresses the options available for cell-based screening of ion channels with examples of their utility and presents case studies on the successful implementation of high-throughput screening campaigns for a ligand-gated ion channel using a fluorescent calcium indicator, and a voltage-gated ion channel using a fluorescent membrane potential sensitive dye. PMID:18694388

  4. Assessment of changes of some functions of Ukrainian acid soils after chemical amelioration

    Directory of Open Access Journals (Sweden)

    Zapko Yurij

    2014-09-01

    Full Text Available The objective of the article was to determine the effectiveness of lime of different origin for chemical amelioration of soils and examine its impact on soil functions such as productivity, habitat, regulation of water quality, and the protective buffer biogeocenotic screen. Limy ameliorants were applied in small local field experiment on Luvic Chernozem, and experiment with lysimeter columns was carried out on Albic Luvisol. The number of the main groups of microflora and enzymatic activity of soil was determined in soil samples taken for the analysis from the root zone. Research concerning the influence of natural and industrial origin ameliorants on soil as habitat showed the correlation of sugar beets productivity with soil biogenic. The increase of biomultiplicity of soil microbiota after addition of a cement dust and negative influence of red sludge on soil as habitat for living organisms was observed. Research involving the influence of ameliorants on soil by lime as the protective buffer biogeocenotic screen was carried out using lysimeter columns. It was stated that the addition of limy ameliorants reduces mobility of heavy metals.

  5. Severe plastic deformation by equal channel angular pressing: product quality and operational details

    Directory of Open Access Journals (Sweden)

    Anibal de Andrade Mendes Filho

    2011-09-01

    Full Text Available As a technique, Equal Channel Angular Pressing (ECAP is simple and inexpensive. However, if die manufacture and operational details are not carefully planned and implemented, difficulties arise, which can interfere with the product characteristics and the pressing operation itself. The present paper offers guidelines on die design and manufacture, emphasizing geometry, material and heat treatment. Further, operational parameters such as lubrication, pressing temperature, deformation routes, die closure procedure and the influence of channel cross section on maximum acceptable load are described. Additionally, the effects of those variables on the product characteristics (deformation level and homogeneity and integrity, plus process control and safety, are discussed.

  6. CERN Services Availability during the CERN Annual Closure 2011

    CERN Multimedia

    IT & GS Departments

    2011-01-01

    General Services: Most of the services provided by the GS Department that do not depend on continuous human presence will remain available during the CERN annual closure. Support levels are reduced during this period, in general the target reaction time for problems will be ½ day. Apart from the heating system, no interruptions are scheduled. In case of failure, the reaction time for restoration of services depends on the arrangements that have been made on a service by service level. Incidents will be documented at http://gssb.web.cern.ch/ For more detailed information please consult the service-portal (http://cern.ch/service-portal). Computing Services Most of the services provided by the IT Department - including WLCG production services - will remain available during the CERN annual closure. No interruptions are scheduled but in case of failure, the restoration of services cannot be guaranteed. Problems will be dealt with on a best effort basis only. However, please note: Experts shoul...

  7. Safety evaluation for the inner canister closure station

    International Nuclear Information System (INIS)

    The Inner Canister Closure Station (ICCS), built by Remote Technology Corporation, will be operability tested. The ICCS is used to remotely leak test Inner Canister Closures (ICC's) and replace ICC's that are not water tight. After operability testing, the ICCS will be inspected and sent to the 717-F mock-up shop for remotability demonstration and dimensional checks, then installed in the Vitrification Building, 221-S. An analysis of potential safety hazards, equipment safety features, and procedural controls indicates that the ICCS can be operated without undue hazard to employees or to the public. A safety inspection and a new equipment inspection will be held before operation to verify that the ICCS meets Savannah River Site safety requirements. 4 refs., 6 figs

  8. Inertial-particle accelerations in turbulence: a Lagrangian closure

    CERN Document Server

    Vajedi, S; Mehlig, B; Biferale, L

    2016-01-01

    The distribution of particle accelerations in turbulence is intermittent, with non-Gaussian tails that are quite different for light and heavy particles. In this article we analyse a closure scheme for the acceleration fluctuations of light and heavy inertial particles in turbulence, formulated in terms of Lagrangian correlation functions of fluid tracers. We compute the variance and the flatness of inertial particle accelerations and we discuss their dependency on the Stokes number. The closure incorporates effects induced by the Lagrangian correlations along the trajectories of fluid tracers, and its predictions agree well with results of direct numerical simulations of inertial particles in turbulence, provided that the effects induced by the inertial preferential sampling of heavy/light particles outside/inside vortices are negligible. In particular, the scheme predicts the correct functional behaviour of the acceleration variance, as a function of Stokes, as well as the presence of a minimum/maximum for ...

  9. Topiramate-induced angle closure with acute myopia, macular striae

    Directory of Open Access Journals (Sweden)

    S Natesh

    2010-01-01

    Full Text Available Topiramate is a sulfamate-substituted monosaccharide used in the treatment of seizures, and prophylaxis of migraine. A number of ocular side-effects have been described with use of topiramate, like bilateral angle closure, acute myopia and macular striae. Ultrasound biomicroscopy (UBM clinches the diagnosis after ruling out other causes of shallow anterior chamber. Previous studies have not demonstrated internal limiting membrane folds presenting as macular striae. We report a case of topiramate-induced acute myopia with angle closure and macular striae in a young adult. This is the first report wherein striae formation after low doses of topiramate and their resolution have been documented by Optical Coherence Tomography (OCT.

  10. Assistant pullback technique for main span closure of Sutong Bridge

    Institute of Scientific and Technical Information of China (English)

    Chen Ming; Luo Chengbin; Wu Qihe; Zhang Yongtao; You Xinpeng

    2009-01-01

    Sutong Bridge is a cable-stayed steel box girder bridge with a main span of 1 088 m. The erection of upper structure adopts geometry control method and requires no change to the unit's size and the structure's none-stress geometry. Before main span closure, the cantilever of girder reaches 540.8 m, the structure state is noticeably influenced by external circumstances, the main span closure face great difficulty. By abstracting the advantage of the pullback method abroad and the domestic temperature-cutting method, a new assistant pullback method have put forward and bring into practice actually. In this paper, the analysis key point of practice conditions, key parameter of practice, main measures of the method and the performance is introduced.

  11. N-Arylazetidines: Preparation through Anionic Ring Closure.

    Science.gov (United States)

    Quinodoz, Pierre; Drouillat, Bruno; Wright, Karen; Marrot, Jérôme; Couty, François

    2016-04-01

    We report herein an efficient synthesis of diversely substituted N-aryl-2-cyanoazetidines based on an anionic ring-closure reaction. These compounds can be prepared from β-amino alcohols in enantiomerically pure form through a three-step sequence involving (i) copper-catalyzed N-arylation, (ii) N-cyanomethylation of the secondary aniline, and (iii) one-pot mesylation followed by ring closure induced by a base. This high-yielding sequence gives access to azetidines with a predictable and adjustable substitution pattern and also with predictable diastereoselectivity. These compounds are susceptible to multiple further derivatizations through Suzuki coupling or nitrile transformation, thus appearing as valuable new scaffolds for medicinal chemistry. Their rigid shape, featuring an almost planar N-arylamine and a planar four-membered ring, was revealed by both AM1 calculations and X-ray crystallography. PMID:26932242

  12. Evaluation of explicit and implicit LES closures for Burgers turbulence

    CERN Document Server

    Maulik, Romit

    2016-01-01

    In this work, we perform an aposteriori error analysis on implicit and explicit large eddy simulation closure models for solving the Burgers turbulence problem. Our closure modeling efforts include both functional and structural models equipped with various low-pass filters. We introduce discrete binomial smoothing filters and an enhanced version of the Van Cittert algorithm to accelerate the convergence of approximate deconvolution processes including regularization and relaxation filtering approaches. Our implicit modeling efforts consist of various high-order schemes including compact and non-compact fifth-order upwind schemes as well as weighted essential non-oscillatory (WENO) and compact reconstructed WENO (CRWENO) schemes, and the resulting schemes are shown to effectively converge to the direct numerical simulation (DNS) for increasing resolutions. Comparing with DNS and underresolved DNS computations, our numerical assessments illustrate the ability of these methods to capture the energy content near...

  13. Triadic closure dynamics drives scaling laws in social multiplex networks

    International Nuclear Information System (INIS)

    Social networks exhibit scaling laws for several structural characteristics, such as degree distribution, scaling of the attachment kernel and clustering coefficients as a function of node degree. A detailed understanding if and how these scaling laws are inter-related is missing so far, let alone whether they can be understood through a common, dynamical principle. We propose a simple model for stationary network formation and show that the three mentioned scaling relations follow as natural consequences of triadic closure. The validity of the model is tested on multiplex data from a well-studied massive multiplayer online game. We find that the three scaling exponents observed in the multiplex data for the friendship, communication and trading networks can simultaneously be explained by the model. These results suggest that triadic closure could be identified as one of the fundamental dynamical principles in social multiplex network formation. (paper)

  14. Closure report for CAU No. 416: Project Shoal Area

    International Nuclear Information System (INIS)

    This Closure Report provides the documentation for closure of the US Department of Energy/Nevada Operations Office (DOE/NV) Project Shoal Area (PSA) Surface Corrective Action Unit (CAU) 416. CAU 416 consists of a mud pit, muckpile, and housekeeping site. The PSA is located approximately 48.3 kilometers (30 miles) southeast of Fallon, Nevada. The mud pit was the result of drilling activities at the PSA in 1963. Investigation activities completed in 1996 determined drilling mud in the mud pit was impacted with petroleum hydrocarbons in excess of the State of Nevada 100 milligram per kilogram (mg/kg). The muckpile consists of broken granite from emplacement shaft and drift (tunnel) mining activities at the PSA in 1963. The housekeeping site consisted of approximately 20 used, empty, rusted, steel 0.9 liter (1 quart) oil cans

  15. SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ae Sin; Jung, Yu Jin; Kim, Dal; Nguyen-Thanh, Tung [Department of Internal Medicine, Chonbuk National University Medical School, Jeonju (Korea, Republic of); Kang, Kyung Pyo [Department of Internal Medicine, Chonbuk National University Medical School, Jeonju (Korea, Republic of); Research Institute of Clinical Medicine of Chonbuk National University, Chonbuk National University Hospital, Jeonju (Korea, Republic of); Lee, Sik [Department of Internal Medicine, Chonbuk National University Medical School, Jeonju (Korea, Republic of); Park, Sung Kwang [Department of Internal Medicine, Chonbuk National University Medical School, Jeonju (Korea, Republic of); Research Institute of Clinical Medicine of Chonbuk National University, Chonbuk National University Hospital, Jeonju (Korea, Republic of); Kim, Won, E-mail: kwon@jbnu.ac.kr [Department of Internal Medicine, Chonbuk National University Medical School, Jeonju (Korea, Republic of); Research Institute of Clinical Medicine of Chonbuk National University, Chonbuk National University Hospital, Jeonju (Korea, Republic of)

    2014-08-08

    deficiency of SIRT2 ameliorates iNOS, NO expression and reactive oxygen species production with suppressing LPS-induced activation of NFκB in macrophages.

  16. Withania Somnifera L Root Extract Ameliorates Toxin Induced Cytotoxicity

    Directory of Open Access Journals (Sweden)

    R.Maheswari

    2015-05-01

    Full Text Available In this study the use of plants for medicinal purpose used locally in the treatment of various diseases and we examined for their antioxidant activity. Therefore, the present investigation is part of continuing programme related to the biochemical screening of local plants used in Ancient Indian Medicine, Ayurveda, Siddha and Yunani. An Aqueous root extract of Withania Somnifera (L. Dunal (Ashwagandha was evaluated for its protective effect (antioxidant effect against Cypermethrin (CM toxin induced oxidation in male albino rats. Cypermethrin, (CM toxin [(RS-3-phenoxybenzyl (IRS-cis-trans-3-(2,2-dichlorovinyl-2,2-dimethyl cyclopropane carboxylate] a Type II pyrethroid pesticide is commonly used in agriculture and many other domestic applications for pest control. Studies have shown that cypermethrin (toxin induces lipid peroxidation and alters the antioxidant status in non-target organisms. Aqueous root extract of Withania Somnifera (L. Dunal (Ashwagandha, a source of several flavonoids and steroids is a potent antioxidant. In our present study, an attempt has been made to study the effect of Cypermethrin (CM toxin on biochemical parameters and ameliorating effect of Withania Somnifera (L. Dunal (Ashwagandha in male wistar rats. Adult male wistar rats were divided into four different groups. Group I Served as vehicle treated normal saline (Control, Group II Rats received intragastric tubing (Ig injection of cypermethrin (CM toxin1/10 LD50 (LD50 of CM is 250mg (25mg/kgbw/day in corn oil, Group III received Withania Somnifera (10% aqueous root extract (5ml of 10% extract per day, for 60 days Group IV Rats received Withania Somnifera aqueous root extract alone (5ml of 10% per day for 60 days treated. Cypermethirn (CM toxin induction leads to reduction in the levels of Enzymic and Non-Enzymic antioxidants levels. However, on treatment with Withania Somnifera aqueous root extract normalized the levels of all the biochemical and hematological

  17. SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

    International Nuclear Information System (INIS)

    deficiency of SIRT2 ameliorates iNOS, NO expression and reactive oxygen species production with suppressing LPS-induced activation of NFκB in macrophages

  18. A special pair of phytohormones controls excitability, slow closure, and external stomach formation in the Venus flytrap.

    Science.gov (United States)

    Escalante-Pérez, María; Krol, Elzbieta; Stange, Annette; Geiger, Dietmar; Al-Rasheid, Khaled A S; Hause, Bettina; Neher, Erwin; Hedrich, Rainer

    2011-09-13

    Venus flytrap's leaves can catch an insect in a fraction of a second. Since the time of Charles Darwin, scientists have struggled to understand the sensory biology and biomechanics of this plant, Dionaea muscipula. Here we show that insect-capture of Dionaea traps is modulated by the phytohormone abscisic acid (ABA) and jasmonates. Water-stressed Dionaea, as well as those exposed to the drought-stress hormone ABA, are less sensitive to mechanical stimulation. In contrast, application of 12-oxo-phytodienoic acid (OPDA), a precursor of the phytohormone jasmonic acid (JA), the methyl ester of JA (Me-JA), and coronatine (COR), the molecular mimic of the isoleucine conjugate of JA (JA-Ile), triggers secretion of digestive enzymes without any preceding mechanical stimulus. Such secretion is accompanied by slow trap closure. Under physiological conditions, insect-capture is associated with Ca(2+) signaling and a rise in OPDA, Apparently, jasmonates bypass hapto-electric processes associated with trap closure. However, ABA does not affect OPDA-dependent gland activity. Therefore, signals for trap movement and secretion seem to involve separate pathways. Jasmonates are systemically active because application to a single trap induces secretion and slow closure not only in the given trap but also in all others. Furthermore, formerly touch-insensitive trap sectors are converted into mechanosensitive ones. These findings demonstrate that prey-catching Dionaea combines plant-specific signaling pathways, involving OPDA and ABA with a rapidly acting trigger, which uses ion channels, action potentials, and Ca(2+) signals. PMID:21896747

  19. Spontaneous closure of an ileostomy: A rare occurrence

    OpenAIRE

    Ashish Saxena; Lovekesh Kumar; Mahendra Singh; Yuvraj Kolhe; Snehal K. Karande; Venkatesh, P.; Sahai, R.N.

    2015-01-01

    INTRODUCTION: Ileostomy is an iatrogenic entero-cutaneous (EC) fistula designed for controlled evacuation of bowel contents. Once ileostomy has served its purpose, it is reverted by surgical procedure. We are reporting an interesting case of spontaneous closure of an ileostomy, obviating the need of surgical intervention. PRESENTATION OF CASE: A 26 year old lady presented with perforation peritonitis. Upon exploration, a tubercular perforation of terminal ileum was found. Loop ileostomy wa...

  20. Postretention stability after orthodontic closure of maxillary interincisor diastemas

    OpenAIRE

    de MORAIS, Juliana Fernandes; de FREITAS, Marcos Roberto; Karina Maria Salvatore de FREITAS; Janson, Guilherme; CASTELLO BRANCO, Nuria

    2014-01-01

    Anterior spaces may interfere with smile attractiveness and compromise dentofacial harmony. They are among the most frequent reasons why patients seek orthodontic treatment. However, midline diastema is commonly cited as a malocclusion with high relapse incidence by orthodontists. Objectives: This study aimed to evaluate the stability of maxillary interincisor diastemas closure and the association of their relapse and interincisor width, overjet, overbite and root parallelism. Material and...

  1. Closure of large midline diastema by a "HIV-Spring".

    Science.gov (United States)

    Harikrishnan, Pandurangan

    2015-01-01

    Midline diastema is a common orthodontic problem in mixed dentition caused by various factors like genetic, supernumery teeth, abnormal frenum attachment, habits and microdontia etc. Large diastemas need closure for the eruption of adjacent teeth. I present here a newly designed customized self active HIV-Spring (Hari Inverted 'V' Spring) for closing a large diastema with minimum orthodontic materials and less activation visits. The spring can be modfied for the three dimensional movement of central incisors. PMID:25881378

  2. Early phacoemulsification in patients with acute primary angle closure

    OpenAIRE

    Moghimi, Sasan; Hashemian, Hesam; Chen, Rebecca; Johari, Mohammadkarim; Mohammadi, Massood; Lin, Shan C.

    2016-01-01

    Purpose To compare long term efficacy of phacoemulsification in the early management of acute primary angle closure (APAC) after aborting an acute attack and performing laser peripheral iridotomy (LPI). Methods In this nonrandomized comparative prospective study, we included 35 subjects presenting with APAC who had responded to medical treatment and LPI with intraocular pressure (IOP) less than 25 mmHg. Twenty patients with visually significant cataract with visual acuity of 21 mmHg with or w...

  3. Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure

    OpenAIRE

    Kucuk, Nurten; Sari, Murat; Midi, Ahmet; Yumusakhuylu, Ali Cemal; Findik, Ozan; Binnetoglu, Adem

    2015-01-01

    Objectives In laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory and digestive system surgery. We investigated the effects of recombinant human growth hormone on pharyngocutaneous fistula closure in Sprague-Dawley rats, based on an increase i...

  4. 2011 River Corridor Closure Contractor Revegetation and Mitigation Monitoring Report

    Energy Technology Data Exchange (ETDEWEB)

    West, W. J.; Lucas, J. G.; Gano, K. A.

    2011-11-14

    This report documents the status of revegetation projects and natural resources mitigation efforts conducted for remediated waste sites and other activities associated with the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 cleanup of National Priorities List waste sites at Hanford. This report contains the vegetation monitoring data that was collected in the spring and summer of 2011 from the River Corridor Closure Contractor’s revegetation and mitigation areas on the Hanford Site.

  5. 2010 River Corridor Closure Contractor Revegetation and Mitigation Monitoring Report

    Energy Technology Data Exchange (ETDEWEB)

    C. T. Lindsey, A. L. Johnson

    2010-09-30

    This report documents eh status of revegetation projects and natural resources mitigation efforts conducted for remediated waste sites and other activities associated with CERLA cleanup of National Priorities List waste sites at Hanford. This report contains vegetation monitoring data that were collected in the spring and summer of 2010 from the River Corridor Closure Contract’s revegetation and mitigation areas on the Hanford Site.

  6. Reduced heating level during the end-of-year closure

    CERN Multimedia

    TS/CV Group

    2005-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperatures have to be maintained to let us know by 16 December 2005 at the latest (tel. 72201 or 77777 or e-mail fm.support@cern.ch). Groups TS/CV and TS/FM

  7. Reduced heating level during the end-of-year closure

    CERN Multimedia

    2006-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature has to be maintained to let us know by 15 December 2006 at the latest (tel. 72201 or 77777 or e-mail fm.support@cern.ch). TS/CV - TS/FM Groups

  8. Reduced heating level during the end-of-year closure

    CERN Multimedia

    2006-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 15 December 2006 at the latest (tel. 72201 or 77777 or e-mail fm.support@cern.ch). TS/CV - TS/FM Groups

  9. Atomistic Simulations of Pore Formation and Closure in Lipid Bilayers

    OpenAIRE

    Bennett, W. F. Drew; Sapay, Nicolas; Tieleman, D. Peter

    2014-01-01

    Cellular membranes separate distinct aqueous compartments, but can be breached by transient hydrophilic pores. A large energetic cost prevents pore formation, which is largely dependent on the composition and structure of the lipid bilayer. The softness of bilayers and the disordered structure of pores make their characterization difficult. We use molecular-dynamics simulations with atomistic detail to study the thermodynamics, kinetics, and mechanism of pore formation and closure in DLPC, DM...

  10. End-of-year closure 2011/2012

    CERN Multimedia

    Human Resouces Department

    2011-01-01

    (Application of Articles R II 4.38 and R II 4.39 of the Staff Regulations) Annual closure of the site of the Organization during the Christmas holidays and days of special leave granted by the Director-General : The Laboratory will be closed from Thursday 22 December 2011 to Wednesday 4 January 2012 inclusive (without deduction of annual leave). The first working day in the New Year will be Thursday 5 January 2012. Tel. 73903

  11. Closure of a nonhealing gastrocutaneous fistula using an endoscopic clip.

    Science.gov (United States)

    Siddiqui, Ali A; Kowalski, Thomas; Cohen, Sidney

    2007-01-01

    Gastrocutaneous fistula after gastrostomy tube removal may persist for a prolonged period. We present a case of a 58-year-old woman with a GCF that had persisted for 5 months following the removal of an endoscopically-placed gastrostomy tube (PEG). Conservative therapy with anti-acid medications and administering motility agents was unsuccessful. For the closure of the GCF, the endoscopic metal clips were used to close the fistula. PMID:17269533

  12. Concrete characterization for the 300 Area Solvent Evaporator Closure Site

    International Nuclear Information System (INIS)

    This report summarizes the sampling activities undertaken and the analytical results obtained in a concrete sampling and analyses study performed for the 300 Area Solvent Evaporator (300 ASE) closure site. The 300 ASE is identified as a Resource Conservation and Recovery Act (RCRA) treatment, storage, or disposal (TSD) unit that will be closed in accordance with the applicable laws and regulations. No constituents of concern were found in concentrations indicating contamination of the concrete by 300 ASE operations

  13. Autocatalytic closure and the evolution of cellular information processing networks

    OpenAIRE

    Decraene, James

    2009-01-01

    Cellular Information Processing Networks (CIPNs) are chemical networks of interacting molecules occurring in living cells. Through complex molecular interactions, CIPNs are able to coordinate critical cellular activities in response to internal and external stimuli. We hypothesise that CIPNs may be abstractly regarded as subsets of collectively autocatalytic (i.e., organisationally closed) reaction networks. These closure properties would subsequently interact with the evolution and adaptatio...

  14. The MOD depleted uranium program independent review board : closure report

    OpenAIRE

    B. Smith

    2007-01-01

    This closure report was prepared by the MOD’s Depleted Uranium Independent Review Board (IRB; see Appendix A for membership) and summarises the review board’s general observations in respect of MOD’s depleted uranium research programme and the associated independent review process. The report starts by providing an introduction to MOD’s research programme on the health and environmental consequences of depleted uranium (DU), membership of the IRB, the operation of the review...

  15. Multi-canister overpack closure operations location study

    International Nuclear Information System (INIS)

    The Spent Nuclear Fuel Path Forward Project (SNF Project) has been established to develop engineered methods for the expedited removal of the irradiated uranium fuel from the K East (KE) and K West (KW) Basins. As specified by the SNF Project, the SNF will be removed from the K Basins, conditioned for dry storage and placed in a long term interim storage facility located in the 200 East Area. The SNF primarily consists of Zircaloy-2 clad uranium fuel discharged from the N-Reactor. A small portion of the SNF is Single Pass Reactor (SPR) Fuel, which is aluminum clad uranium fuel. The SNF will be loaded into Multi-Canister Overpacks (MCOs) at the K Basins, transferred to the Cold Vacuum Drying (CVD) facility for initial fuel conditioning, and transported to the Canister Storage Building (CSB) for staging, final fuel conditioning, and dry storage. The MCO is a transportation, conditioning, and storage vessel. The MCO consists of a 24 inch pipe with a welded bottom closure and a top closure that is field welded after the MCO is loaded with SNF. The MCO is handled and transported in the vertical orientation during all operations. Except for operations within the CSB, the MCO is always within the transportation cask which primarily provides radiological shielding and structural protection of the MCO. The MCO closure operations location study provides a relative evaluation of location options at the K Basins and the CVD Facility and recommends that the MCO closure weld be performed, inspected, and repaired at the CVD Facility

  16. Closure relations for CFD simulation of bubble columns

    OpenAIRE

    Ziegenhein, Thomas; Lucas, Dirk; Rzehak, Roland; Krepper, Eckhard

    2014-01-01

    This paper describes the modelling of bubbly flow in a bubble column considering non-drag forces, polydispersity and bubble induced turbulence using the Eulerian two-fluid approach. The set of used closure models describing the momentum exchange between the phases was chosen on basis of broad experiences in modelling bubbly flows at the Helmholtz-Zentrum Dresden-Rossendorf. Polydispersity is modeled using the inhomogeneous multiple size group (iMUSIG) model, which was developed...

  17. Underground storage tank 431-D1U1, Closure Plan

    Energy Technology Data Exchange (ETDEWEB)

    Mancieri, S.

    1993-09-01

    This document contains information about the decommissioning of Tank 431-D1U1. This tank was installed in 1965 for diesel fuel storage. This tank will remain in active usage until closure procedures begin. Soils and ground water around the tank will be sampled to check for leakage. Appendices include; proof of proper training for workers, health and safety briefing record, task hazard analysis summary, and emergency plans.

  18. Reduced heating level during the end-of-year closure

    CERN Multimedia

    2004-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 16 December 2004 at the latest (tel. 72201 or 77777 or e-mail fm.support@cern.ch.). TS/CV - TS/FM Groups

  19. Reduced heating level during the end-of-year closure

    CERN Multimedia

    2007-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 14 December 2007 at the latest (tel. 72201 or 77777 or e-mail mailto:fm.support@cern.ch). TS/CV - TS/FM Groups

  20. Reduced heating level during the end-of-year closure

    CERN Multimedia

    ST Department

    2007-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperatures have to be maintained to let us know by 14 December 2007 at the latest (tel. 72201 or 77777 or e-mail fm.support@cern.ch). TS/CV - TS/FM Groups

  1. Reduced heating level during the end-of-year closure

    CERN Multimedia

    TS Department

    2008-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 12 December 2008 at the latest (tel. 72201 or 77777 or e-mail mailto:fm.support@cern.ch). TS/CV - TS/FM Groups

  2. Reduced heating level during the end-of-year closure

    CERN Multimedia

    TS/CV-TS/FM Group

    2004-01-01

    To save on energy costs, the heating will once again be operating at a reduced level during the end-of-year closure of the Laboratory. We would ask all those in charge of premises where normal temperature have to be maintained to let us know by 16 December 2004 at the latest (tel. 72201 or 77777 or e-mail fm.support@cern.ch.).

  3. Shell closure effects studied via cluster decay in heavy nuclei

    OpenAIRE

    Kumar, Sushil; Ramna; Kumar, Rajesh

    2011-01-01

    The effects of shell closure in nuclei via the cluster decay is studied. In this context, we have made use of the Preformed Cluster Model ($PCM$) of Gupta and collaborators based on the Quantum Mechanical Fragmentation Theory. The key point in the cluster radioactivity is that it involves the interplay of close shell effects of parent and daughter. Small half life for a parent indicates shell stabilized daughter and long half life indicates the stability of the parent against the decay. In th...

  4. Classes of Spatiotemporal Objects and Their Closure Properties

    OpenAIRE

    Chomicki, Jan; Haesevoets, Sofie; Kuijpers, Bart; Revesz, Peter

    2002-01-01

    We present a data model for spatio-temporal databases. In this model spatio-temporal data is represented as a finite union of objects described by means of a spatial reference object, a temporal object and a geometric transformation function that determines the change or movement of the reference object in time. We define a number of practically relevant classes of spatio-temporal objects, and give complete results concerning closure under Boolean set operators for these classes. Since only f...

  5. HAS AN IMPORTANT TEST BEEN OVERLOOKED?: CLOSURE FLEXIBILITY IN SCHIZOPHRENIA

    OpenAIRE

    Butler, Pamela D.; Schechter, Isaac; Revheim, Nadine; Silipo, Gail; Javitt, Daniel C.

    2010-01-01

    Deficits in visual processing are now recognized as a core feature of schizophrenia. In the 1940’s, Louis Thurstone developed a series of tests designed to evaluate specific aspects of visual perceptual processing including the Closure Flexibility Test (CFT), which was designed to measure “the ability to hold a configuration in mind despite distraction.” The present study evaluated patients’ performance on this task and its relationship to other tests of neuropsychological function, particula...

  6. Validity conditions for moment closure approximations in stochastic chemical kinetics

    OpenAIRE

    Schnoerr, David; Sanguinetti, Guido; Grima, Ramon

    2014-01-01

    Approximations based on moment-closure (MA) are commonly used to obtain estimates of the mean molecule numbers and of the variance of fluctuations in the number of molecules of chemical systems. The advantage of this approach is that it can be far less computationally expensive than exact stochastic simulations of the chemical master equation. Here, we numerically study the conditions under which the MA equations yield results reflecting the true stochastic dynamics of the system. We show tha...

  7. Closure to efficient causation, computability and artificial life

    OpenAIRE

    Cárdenas, M.L. María Luz; Letelier, Juan-Carlos; Gutiérrez, Claudio; Cornish-Bowden, Athel; Soto-Andrade, Jorge

    2010-01-01

    Abstract The major insight in Robert Rosen's view of a living organism as an (M,R)-system was the realization that an organism must be ?closed to efficient causation?, which means that the catalysts needed for its operation must be generated internally. This aspect is not controversial, but there has been confusion and misunderstanding about the logic Rosen used to achieve this closure. In addition, his corollary that an organism is not a mechanism and cannot have simulable models ...

  8. Topiramate-induced angle closure with acute myopia, macular striae

    OpenAIRE

    Natesh, S.; Rajashekhara, S. K.; Rao, A. S. D.; B Shetty

    2010-01-01

    Topiramate is a sulfamate-substituted monosaccharide used in the treatment of seizures, and prophylaxis of migraine. A number of ocular side-effects have been described with use of topiramate, like bilateral angle closure, acute myopia and macular striae. Ultrasound biomicroscopy (UBM) clinches the diagnosis after ruling out other causes of shallow anterior chamber. Previous studies have not demonstrated internal limiting membrane folds presenting as macular striae. We report a case of topira...

  9. Channel Choice: A Literature Review

    DEFF Research Database (Denmark)

    Østergaard Madsen, Christian; Kræmmergaard, Pernille

    2015-01-01

    The channel choice branch of e-government studies citizens’ and businesses’ choice of channels for interacting with government, and how government organizations can integrate channels and migrate users towards the most cost-efficient channels. In spite of the valuable contributions offered no sys...... systematic overview exist of channel choice. We present a literature review of channel choice studies in government to citizen context identifying authors, countries, methods, concepts, units of analysis, and theories, and offer suggestionsfor future studies....

  10. Applying Lean Concepts to Waste Site Closure - 13137

    International Nuclear Information System (INIS)

    Washington Closure Hanford (WCH) was selected by the U.S. Department of Energy, Richland Operations Office to manage the River Corridor Closure Project, a 10-year contract in which WCH will clean up 220 mi2 of contaminated land at the Hanford Site in Richland, Washington. In the summer of 2011, with Tri-Party (DOE-RL, Environmental Protection Agency and Washington State Department of Ecology) Agreement Milestones due at the end of the calendar year, standard work practices were challenged in regards to closure documentation development. The Lean process, a concept that maximizes customer value while minimizing waste, was introduced to WCH's Sample Design and Cleanup Verification organization with the intention of eliminating waste and maximizing efficiencies. The outcome of implementing Lean processes and concepts was impressive. It was determined that the number of non-value added steps far outnumbered the value added steps. Internal processing time, document size, and review times were all reduced significantly; relationships with the customer and the regulators were also improved; and collaborative working relationships with the Tri Parties have been strengthened by working together on Lean initiatives. (authors)

  11. Incidence of Ostomy Site Incisional Hernias after Stoma Closure.

    Science.gov (United States)

    Sharp, Stephen P; Francis, Jacquelyn K; Valerian, Brian T; Canete, Jonathan J; Chismark, A David; Lee, Edward C

    2015-12-01

    This study sought to evaluate the incidence of ostomy site incisional hernias after stoma reversal at a single institution. This is a retrospective analysis from 2001 to 2011 evaluating the following demographics: age, gender, indication for stoma, urgent versus elective operation, time to closure, total follow-up time, the incidence of and reoperation for stoma incisional hernia, diabetes, postoperative wound infection, smoking status within six months of surgery, body mass index, and any immunosuppressive medications. A total of 365 patients were evaluated. The median follow-up time was 30 months. The clinical hernia rate was 19 percent. Significant risk factors for hernia development were age, diabetes, end colostomies, loop colostomies, body mass index >30, and undergoing an urgent operation. The median time to clinical hernia detection was 32 months. Sixty-four percent of patients required surgical repair of their stoma incisional hernia. A significant number of patients undergoing stoma closure developed an incisional hernia at the prior stoma site with the majority requiring definitive repair. These hernias are a late complication after stoma closure and likely why they are under-reported in the literature. PMID:26736162

  12. Bilateral Acute Angle-Closure Glaucoma Induced By Escitalopram

    Directory of Open Access Journals (Sweden)

    Dilbade Yıldız Ekinci

    2014-10-01

    Full Text Available Escitalopram is an antidepressant of the selective serotonin reuptake inhibitor(SSRI class. In this manuscript, we report the case of a female patient who developed bilateral acute angle-closure glaucoma induced by escitalopram. A 46-year-old female patient was admitted to our ophthalmology clinic with complaints of severe pain around the both eyes, headache, nausea, and vomiting for two days. In her past medical history, she was using escitalopram for depression for two years. Visual acuity was at hand movement level in both eyes. Anterior segment examination showed bilateral diffuse conjunctival hyperemia, corneal edema, shallow anterior chamber, and fixed dilated pupils. Intraocular pressure was 47 mmHg in the right and 68 mmHg in the left eye. The diagnosis was acute angle-closure glaucoma, and the escitalopram medication was discontinued. She was treated with topical and systemic antiglaucomatous medication. After the cornea become clear, bilateral peripheral laser iridotomy was done. In the following year, she did not begin escitalopram medication again and no other acute angle-closure attack was seen. (Turk J Ophthalmol 2014; 44:396-9

  13. Towards a collisionless fluid closure in plasma turbulence

    International Nuclear Information System (INIS)

    In this work 2 generic possible descriptions of a plasma have been compared namely the kinetic and the fluid approaches. The latter focuses on the successive moments (n, u, p, q,...) of the distribution function, whereas the former describes the time-evolution in phase space of this distribution function, both being based on the Vlasov equation. The fluid description is attractive for the Vlasov equation is tractable with great difficulties. Nevertheless it rests on a major difficulty: as the set of fluid equations constitute an infinite hierarchy, a closure equation must be chosen. The first chapter details physical characteristics of a fundamental kinetic interaction mechanism between waves and particles. In chapter 2 we propose a fluid closure that allows analytic comparison with a linear fully kinetic result, near an homogeneous, electrostatic, Maxwellian equilibrium. This approach consists in adjusting chosen parameters in order to minimize the discrepancies between fluid and kinetic linear response functions. In chapter 3 we present a general frame for a fluid closure in a magnetized plasma. This is attempted in a linear, simplified model with low dimensionality

  14. Criteria for rational smoothness of some symmetric orbit closures

    CERN Document Server

    Hultman, Axel

    2009-01-01

    Let $G$ be a connected reductive linear algebraic group over $\\C$ with an involution $\\theta$. Denote by $K$ the subgroup of fixed points. In certain cases, the $K$-orbits in the flag variety $G/B$ are indexed by the twisted identities $\\iot = \\{\\theta(w^{-1})w\\mid w\\in W\\}$ in the Weyl group $W$. Under this assumption, we establish a criterion for rational smoothness of orbit closures which generalises classical results of Carrell and Peterson for Schubert varieties. That is, whether an orbit closure is rationally smooth at a given point can be determined by examining the degrees in a ``Bruhat graph'' whose vertices form a subset of $\\iot$. Moreover, an orbit closure is rationally smooth everywhere if and only if its corresponding interval in the Bruhat order on $\\iot$ is rank symmetric. In the special case $K=\\Sp_{2n}(\\C)$, $G=\\SL_{2n}(\\C)$, we strengthen our criterion by showing that only the degree of a single vertex, the ``bottom one'', needs to be examined. This generalises a result of Deodhar for type ...

  15. Energy balance closure at ChinaFLUX sites

    Institute of Scientific and Technical Information of China (English)

    LI; Zhengquan; YU; Guirui; WEN; Xuefa; ZHANG; Leiming; REN

    2005-01-01

    Network of eddy covariance observation is measuring long-term carbon and water fluxes in contrasting ecosystems and climates. As one important reference of independently evaluating scalar flux estimates from eddy covariance, energy balance closure is used widely in study of carbon and water fluxes. Energy balance closure in ChinaFLUX was evaluated by statistical regression of turbulent energy fluxes (sensible and latent heat) against available energy (net radiation, soil heat flux, canopy heat storage) and the energy balance ratio (EBR) and the frequency distribution of relative errors of energy balance (δ). The trends of diurnal and seasonal variation of energy balance in ChinaFLUX were analyzed. The results indicated that the imbalance was prevalent in all observation sites, but there were little differences among sites because of the properties variation of sites. The imbalance was greater during nocturnal periods than daytime and closure was improved with friction velocity intensifying. Generally the results suggested that estimates of the scalar turbulent fluxes of sensible and latent heat were underestimated and/or that available energy was overestimated. Finally, we discussed certain factors that are contributed to the imbalance of energy, such as systematic errors associated with the sampling mismatch, systematic instrument bias, neglected energy sinks, low and high frequency loss of turbulent fluxes and advection of heat and water vapor.

  16. Beliefs in Conspiracy Theories and the Need for Cognitive Closure

    Directory of Open Access Journals (Sweden)

    PatrickJohnLEMAN

    2013-06-01

    Full Text Available An important component of conspiracy theories is how they influence, and are influenced by, the evaluation of potential evidence. Some individuals may be more open minded regarding certain explanations for events whereas others may seek closure and thus cut off a conspiracy explanation. Two studies examined the relationship between the need for cognitive closure (NFCC, levels of belief in real world conspiracy theories, and the attribution of conspiracy theories to explain events. A first, small (N=30 and preliminary study found no relationship between NFCC and beliefs in conspiracy theories, suggesting that both advocates and opponents of conspiracy explanations do not differ on this dimension. A second study (N=86 revealed that evidence for and against conspiracy theories had an influence on attributions of the likelihood of a conspiracy to explain a novel event. Specifically, after reading evidence individuals with high levels of belief in conspiracy theories tended to rate a conspiracy explanation as more likely whereas those with low levels of belief rated it as less likely. However, when the need for cognitive closure was experimentally lowered the effects of prior beliefs in conspiracy theories diminished.

  17. Towards a collisionless fluid closure in plasma turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Dif Pradalier, G

    2005-07-01

    In this work 2 generic possible descriptions of a plasma have been compared namely the kinetic and the fluid approaches. The latter focuses on the successive moments (n, u, p, q,...) of the distribution function, whereas the former describes the time-evolution in phase space of this distribution function, both being based on the Vlasov equation. The fluid description is attractive for the Vlasov equation is tractable with great difficulties. Nevertheless it rests on a major difficulty: as the set of fluid equations constitute an infinite hierarchy, a closure equation must be chosen. The first chapter details physical characteristics of a fundamental kinetic interaction mechanism between waves and particles. In chapter 2 we propose a fluid closure that allows analytic comparison with a linear fully kinetic result, near an homogeneous, electrostatic, Maxwellian equilibrium. This approach consists in adjusting chosen parameters in order to minimize the discrepancies between fluid and kinetic linear response functions. In chapter 3 we present a general frame for a fluid closure in a magnetized plasma. This is attempted in a linear, simplified model with low dimensionality.

  18. Administrative closure methodology for the development of transmission projects

    Directory of Open Access Journals (Sweden)

    Denys Garcia

    2013-09-01

    Full Text Available ABSTRACTThe objective of this research was to propose a methodology for administrative closure of the transmission development projects in the electricity sector in Zulia state. It was classified as descriptive, considered feasible project and considering a methodology for the analysis and description of the variable studied. Likewise, the research design was non-experimental field, transactional and descriptive. The target population was 18 subjects, members of companies in the electricity sector State. The data collection technique used in this research was the survey instrument as a questionnaire, which was evaluated according to the Cronbach reliability coefficient, obtaining a score of 0.86, which puts you a high level of reliability. Through the evaluation of the results obtained in applying the instrument is able to diagnose the current situation in the closing phase of projects, resulting in a lower domain of the steps and elements needed to perform a proper shutdown. Therefore we designed a methodology which provides guidance for the administrative closure of the transmission development projects in the electricity sector in Zulia state, schematically and systematized, which comprises a set of discrete steps and aimed at strengthening and improvement issues identified opportunities to improve the process for closing projects.Keywords: Methodology, Administrative closure, Projects, Transmission, Development.

  19. Comparison of Subcuticular Suture Materials in Cesarean Skin Closure

    Directory of Open Access Journals (Sweden)

    Pınar Solmaz Hasdemir

    2015-01-01

    Full Text Available Aim. Comparison of the rate of wound complications, pain, and patient satisfaction based on used subcuticular suture material. Methods. A total of 250 consecutive women undergoing primary and repeat cesarean section with low transverse incision were prospectively included. The primary outcome was wound complication rate including infection, dehiscence, hematoma, and hypertrophic scar formation within a 6-week period after operation. Secondary outcomes were skin closure time, the need for use of additional analgesic agent, pain score on numeric rating scale, cosmetic score, and patient scar satisfaction scale. Results. Absorbable polyglactin was used in 108 patients and nonabsorbable polypropylene was used in 142 patients. Wound complication rates were similar in primary and repeat cesarean groups based on the type of suture material. Skin closure time is longer in nonabsorbable suture material group in both primary and repeat cesarean groups. There was no difference between groups in terms of postoperative pain, need for additional analgesic use, late phase pain, and itching at the scar. Although the cosmetic results tended to be better in the nonabsorbable group in primary surgery patients, there was no significant difference in the visual satisfaction of the patients. Conclusions. Absorbable and nonabsorbable suture materials are comparable in cesarean section operation skin closure.

  20. Fatigue crack closure in submicron-thick freestanding copper films

    International Nuclear Information System (INIS)

    The fatigue crack closure in approximately 500-nm-thick freestanding copper films were investigated by in situ field emission scanning electron microscope (FESEM) observations of the fatigue crack opening/closing behavior at three stress ratios of R=0.1, 0.5, and 0.8 in the low–Kmax (maximum stress intensity factor) region of Kmax<4.5 MPam1/2. The direct observation of fatigue cracks clarified that crack closure occurred at R=0.1 and 0.5, while the fatigue crack was always open at R=0.8. Changes in the gage distance across the fatigue crack during a fatigue cycle were measured from the FESEM images, and the crack opening stress intensity factor Kop was evaluated on the basis of the stress intensity factor K vs. the gage distance relationship. The effective stress intensity factor range ΔKeff=Kmax−Kop was then evaluated. The R-dependence of the da/dN vs. ΔKeff relationship was smaller than that of the da/dN vs. ΔK relationship. This suggests that ΔKeff is a dominating parameter rather than ΔK in the fatigue crack propagation in the films. This paper is the first report on the presence of the fatigue crack closure in submicron-thick freestanding metallic films