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Sample records for changing regulatory environment

  1. The changing regulatory environment

    International Nuclear Information System (INIS)

    The role and value of regulation in the energy sector was discussed, demonstrating how, despite common perception, regulation is an essential part of Canada's strategy to find and develop new opportunities. The future vision of regulation for industry participants was presented with particular focus on issues related to streamlining the regulatory process. As far as pipelines are concerned, regulatory actions are necessary to facilitate capacity increases and to ensure the line's integrity, safety and environmental record. Furthermore, regulation provides economic solutions where market forces cannot provide them, as for example where business has elements of monopoly. It arbitrates interests of landowners, business, consumers, and environmental groups. It looks for ways to ensure conditions under which competition can flourish. It acts as the guardian of citizens' rights in a democratic society by providing citizens with an opportunity to be heard on the building or expansion of pipelines and associated facilities. As citizens become more and more concerned about their property and the land that surrounds them, citizen involvement in decision making about how industry activity affects their quality of life will become correspondingly more important. Regulatory agencies are committed to facilitate this engagement by flexible hearing procedures and by making use of evolving communication and information technology

  2. Evolution of regulatory networks towards adaptability and stability in a changing environment.

    Science.gov (United States)

    Lee, Deok-Sun

    2014-11-01

    Diverse biological networks exhibit universal features distinguished from those of random networks, calling much attention to their origins and implications. Here we propose a minimal evolution model of Boolean regulatory networks, which evolve by selectively rewiring links towards enhancing adaptability to a changing environment and stability against dynamical perturbations. We find that sparse and heterogeneous connectivity patterns emerge, which show qualitative agreement with real transcriptional regulatory networks and metabolic networks. The characteristic scaling behavior of stability reflects the balance between robustness and flexibility. The scaling of fluctuation in the perturbation spread shows a dynamic crossover, which is analyzed by investigating separately the stochasticity of internal dynamics and the network structure differences depending on the evolution pathways. Our study delineates how the ambivalent pressure of evolution shapes biological networks, which can be helpful for studying general complex systems interacting with environments. PMID:25493848

  3. Evolution of regulatory networks towards adaptability and stability in a changing environment

    Science.gov (United States)

    Lee, Deok-Sun

    2014-11-01

    Diverse biological networks exhibit universal features distinguished from those of random networks, calling much attention to their origins and implications. Here we propose a minimal evolution model of Boolean regulatory networks, which evolve by selectively rewiring links towards enhancing adaptability to a changing environment and stability against dynamical perturbations. We find that sparse and heterogeneous connectivity patterns emerge, which show qualitative agreement with real transcriptional regulatory networks and metabolic networks. The characteristic scaling behavior of stability reflects the balance between robustness and flexibility. The scaling of fluctuation in the perturbation spread shows a dynamic crossover, which is analyzed by investigating separately the stochasticity of internal dynamics and the network structure differences depending on the evolution pathways. Our study delineates how the ambivalent pressure of evolution shapes biological networks, which can be helpful for studying general complex systems interacting with environments.

  4. Regulatory management systems: Adapting to changes in the environment [Session summary

    International Nuclear Information System (INIS)

    Full text: The presentations and the discussions identified a number of key challenges that regulatory bodies are facing. These include challenges in maintaining and improving competence, as well as establishing the necessary policies and approaches to deal with new situations, mainly resulting from ageing or the prolonged operation of NPPs, the construction of new NPPs, the decommissioning of nuclear installations and the establishment of the waste management infrastructure. Declining education and research infrastructure is also observed in many countries. There is, therefore, an increasing need to: (1) Create an attractive environment for students in the nuclear safety area, to implement more aggressive recruitment strategies, to ensure that sustainable education and training capabilities are in place in the Member States and that a comprehensive knowledge management system is implemented in the regulatory bodies; (2) Consider cooperative efforts for activities demanding high resources. Further discussion may be needed on cooperation efforts for activities, such as new reactor design certification. The globalization of the energy market and the resulting changes in the structure and the management of the operating organizations lead the regulatory bodies to adapt their strategies. Particular attention is requested for ensuring the qualification of the operating organizations, and reviewing and inspecting the organizational performance in achieving and maintaining a high level of safety for the short term and the long term. Globalization also calls for more harmonization of regulatory requirements where appropriate. Efforts in this direction are pursued at the regional levels, acknowledging that harmonization does not mean uniformity. The role of the IAEA safety standards in building an international nuclear safety regime has also increased. The regulatory community will benefit strongly from cross-fertilization between the regional and multinational efforts, and

  5. Ionizing radiation sources: very diversified means, multiple applications and a changing regulatory environment. Conference proceedings

    International Nuclear Information System (INIS)

    This document brings together the available presentations given at the conference organised by the French society of radiation protection about ionizing radiation source means, applications and regulatory environment. Twenty eight presentations (slides) are compiled in this document and deal with: 1 - Overview of sources - some quantitative data from the national inventory of ionizing radiation sources (Yann Billarand, IRSN); 2 - Overview of sources (Jerome Fradin, ASN); 3 - Regulatory framework (Sylvie Rodde, ASN); 4 - Alternatives to Iridium radiography - the case of pressure devices at the manufacturing stage (Henri Walaszek, Cetim; Bruno Kowalski, Welding Institute); 5 - Dosimetric stakes of medical scanner examinations (Jean-Louis Greffe, Charleroi hospital of Medical University); 6 - The removal of ionic smoke detectors (Bruno Charpentier, ASN); 7 - Joint-activity and reciprocal liabilities - Organisation of labour risk prevention in case of companies joint-activity (Paulo Pinto, DGT); 8 - Consideration of gamma-graphic testing in the organization of a unit outage activities (Jean-Gabriel Leonard, EDF); 9 - Radiological risk control at a closed and independent work field (Stephane Sartelet, Areva); 10 - Incidents and accidents status and typology (Pascale Scanff, IRSN); 11 - Regional overview of radiation protection significant events (Philippe Menechal, ASN); 12 - Incident leading to a tritium contamination in and urban area - consequences and experience feedback (Laurence Fusil, CEA); 13 - Experience feedback - loss of sealing of a calibration source (Philippe Mougnard, Areva); 14 - Blocking incident of a 60Co source (Bruno Delille, Salvarem); 15 - Triggering of gantry's alarm: status of findings (Philippe Prat, Syctom); 16 - Non-medical electric devices: regulatory changes (Sophie Dagois, IRSN; Jerome Fradin, ASN); 17 - Evaluation of the dose equivalent rate in pulsed fields: method proposed by the IRSN and implementation test (Laurent Donadille, IRSN); 18

  6. Transforming public utility commissions in the new regulatory environment: Some issues and ideas for managing change

    Energy Technology Data Exchange (ETDEWEB)

    Wirick, D.W.; Davis, V.W.; Burns, R.E.; Jones, D.N.

    1996-07-01

    In the face of sweeping changes in utility markets and regulatory practices, public utility commissions are being forced to change in fundamental ways--to substantially transform themselves rather than to make only incremental changes in their operations. Managing this process of radical change is complicated by the fact that for the foreseeable future some portions of utility markets (e.g., water utilities) will function much as they have before. Some envision commissions in the future that are more externally focussed, that rely more on dispute resolution than adjudicatory proceedings, that concentrate on identifying and understanding competitive markets, that are more automated, and that are more likely to question old assumptions and definitions. This report identifies the considerations commissions might apply for identifying what mix of skills or fields of experise should compromise the technical staff. Factors are also identified which point towards a sectoral arrangement of staff and those factors which point toward a functional approach.

  7. Deliberations on nuclear safety regulatory system in a changing industrial environment

    International Nuclear Information System (INIS)

    Nuclear safety concern, which may accompany such external environmental factors as privatization and restructuring of the electric power industry, is emerging as an international issue. In order to cope with the concern about nuclear safety, it is important to feedback valuable experiences of advanced countries that restructured their electric power industries earlier and further to reflect the current safety issues, which are raised internationally, fully into the nuclear safety regulatory system. This paper is to review the safety issues that might take place in the process of increasing competition in the nuclear power industry, and further to present a basic direction and effective measures for ensuring nuclear safety in response thereto from the viewpoint of safety regulation. It includes a political direction for a regulatory body's efforts to rationalize and enforce efficiently its regulation. It proposes to ensure that regulatory specialty and regulatory cost are stably secured. Also, this paper proposes maintaining a sound nuclear safety regulatory system to monitor thoroughly the safety management activities of the industry, which might be neglected as a result of focusing on reduction of the cost for producing electric power. (author)

  8. The air quality and regional climate effects of widespread solar power generation under a changing regulatory environment

    Science.gov (United States)

    Millstein, D.; Zhai, P.; Menon, S.

    2011-12-01

    used to investigate the effects of the various solar generation scenarios given emissions projections that account for changing regulatory environment, economic and population growth, and technological change. The results will help to quantify the potential air quality benefits of promotion of solar electricity generation in regions containing high penetration of coal-fired power generation. Note current national solar incentives that are based only on solar generation capacity. Further investigation of changes to regional climate due to emission reductions of aerosols and relevant precursors will provide insight into the environmental effects that may occur if solar power generation becomes widespread.

  9. Regulatory challenges in today's changing economy - adapting SKI to the new environment

    International Nuclear Information System (INIS)

    In Sweden there are 11 operating reactors contributing to about half of electricity demands. The installed capacity is about 10 GW electricity. Challenges facing nuclear safety are economic pressure on utilities due to deregulation, ageing reactors and final disposal of nuclear waste. European integration, enlargement of the European Union and the national energy policy are other challenges. The last one is creating uncertainty for the future of nuclear power in the country. Moreover, there is an increased demand from stakeholders of an efficient, open and transparent regulatory body. A nuclear accident must not happen - nuclear waste must be taken care of safely - nuclear material must be controlled. These are the overriding driving forces behind SKI's mission. SKI is the Swedish nuclear safety regulator employing some 110 persons. In my contribution I will develop some aspects of the new safety challenges, discuss how they manifest themselves and outline SKI's regulatory strategy. SKI continues to act in order to make sure nuclear safety is not compromised through the maintenance of a strong national safety regulator with an active international program. (author)

  10. A reappraisal of transport aircraft needs 1985 - 2000: Perceptions of airline management in a changing economic, regulatory, and technological environment

    Science.gov (United States)

    Spencer, F. A.

    1982-01-01

    Views of the executives of 24 major, national, regional, and commuter airlines concerning the effect of recent regulatory, economic, and technological changes on the roles they see for their airlines, and consequent changes in their plans for acquiring aircraft for the 1985 to 2000 period were surveyed. Differing perceptions on the economic justification for new-technology jets in the context of the carriers' present and projected financial conditions are outlined. After examining the cases for new or intermediate size jets, the study discusses turboprop powered transports, including the carriers' potential interest in an advanced technology, high-speed turboprop or prop-fan. Finally, the implications of foreign competition are examined in terms of each carrier's evaluation of the quality and financial offerings, as well as possible 'Buy American' policy predisposition.

  11. The U.S. Nuclear Regulatory Commission Thermal-Hydraulic Research Program: Maintaining expertise in a changing environment

    International Nuclear Information System (INIS)

    Throughout the 1970s and early 1980s, the U.S. Nuclear Regulatory Commission's (NRC's) thermal-hydraulic research program enjoyed ample funding, sponsored extensive experimental and analytical development programs, and attracted worldwide expertise. With the completion of the major experimental programs and with the promulgation of the revised emergency core-cooling system rule, both the funding and prominence of thermal-hydraulic research at the NRC have declined in recent years. This has led justifiably to the concern by some that the program may no longer have the minimal elements needed to maintain both expertise and world-class status. The purpose of this article is to describe the NRC's current thermal-hydraulic research program and to show how this program ensures maintenance of a viable, robust research effort and retention of needed expertise and international leadership

  12. Environment, safety, and health regulatory implementation plan

    International Nuclear Information System (INIS)

    To identify, document, and maintain the Uranium Mill Tailings Remedial Action (UMTRA) Project's environment, safety, and health (ES ampersand H) regulatory requirements, the US Department of Energy (DOE) UMTRA Project Office tasked the Technical Assistance Contractor (TAC) to develop a regulatory operating envelope for the UMTRA Project. The system selected for managing the UMTRA regulatory operating envelope data bass is based on the Integrated Project Control/Regulatory Compliance System (IPC/RCS) developed by WASTREN, Inc. (WASTREN, 1993). The IPC/RCS is a tool used for identifying regulatory and institutional requirements and indexing them to hardware, personnel, and program systems on a project. The IPC/RCS will be customized for the UMTRA Project surface remedial action and groundwater restoration programs. The purpose of this plan is to establish the process for implementing and maintaining the UMTRA Project's regulatory operating envelope, which involves identifying all applicable regulatory and institutional requirements and determining compliance status. The plan describes how the Project will identify ES ampersand H regulatory requirements, analyze applicability to the UMTRA Project, and evaluate UMTRA Project compliance status

  13. The Political Economy of Regulatory Change

    DEFF Research Database (Denmark)

    Buch-Hansen, Hubert

    2012-01-01

    This article aims to explain the broader evolution of British merger control. To this end it outlines a novel critical political economy perspective on regulation and regulatory change which differs from established political economy approaches, such as the regulatory capitalism/state perspectives......, in three main ways: it places regulatory ideas at the heart of the analysis, it differentiates between different degrees of regulatory change, and it links regulatory change in delineated issue areas with changing power balances between fractions of capital and labor. The application of this...

  14. Wetlands: The changing regulatory landscape

    International Nuclear Information System (INIS)

    Protection of wetlands became a national issue in 1988 when President George Bush pledged no net loss of wetlands in the US under his open-quotes environmental presidency.close quotes As wetlands became a national issue, the job of protecting them became an obligation for many groups, including hydro-power developers. Now, when a site selected for development includes an area that may be classified as a wetland, the developer quickly discovers the importance of recognizing and protecting these natural habitats. Federal legislation severely limits development of wetland, and most states increase the restrictions with their own wetlands regulations. The difficulty of defining wetlands complicates federal and state enforcement. Land that appears to be dry may in fact be classified as a wetland. So, even if a site appears dry, potential hydro developers must confirm whether or not any jurisdictional wetlands are present. Regulated lands include much more than marshes and swamps. Further complicating the definition of wetlands, a recent court decision found that even artificially created wetlands, such as man-made ponds, may be subject to regulation. Hydro developers must be aware of current regulatory requirements before they consider development of any site that may contain wetlands. To be certain that a site is open-quotes buildableclose quotes from the standpoint of wetlands regulation, a developer must verify (with the help of state agencies) that the property does not contain any jurisdictional wetlands. If it does, the regulatory process before development becomes much more complicated. For the short term, uncertainty abounds and extreme caution is in order. Because the regulatory process has become so complex and an agreeable definition of wetlands so elusive, the trend among the Corps and collaborating agencies is to constrict nationwide permits in favor of narrowing the jurisdictional definition of wetlands

  15. Mission Risk Reduction Regulatory Change Management

    Science.gov (United States)

    Scroggins, Sharon

    2007-01-01

    NASA Headquarters Environmental Management Division supports NASA's mission to pioneer the future in space exploration, scientific discovery, and aeronautics research by integrating environmental considerations into programs and projects early-on, thereby proactively reducing NASA's exposure to institutional, programmatic and operational risk. As part of this effort, NASA established the Principal Center for Regulatory Risk Analysis and Communication (RRAC PC) as a resource for detecting, analyzing, and communicating environmental regulatory risks to the NASA stakeholder community. The RRAC PC focuses on detecting emerging environmental regulations and other operational change drivers that may pose risks to NASA programs and facilities, and effectively communicating the potential risks. For example, regulatory change may restrict how and where certain activities or operations may be conducted. Regulatory change can also directly affect the ability to use certain materials by mandating a production phase-out or restricting usage applications of certain materials. Regulatory change can result in significant adverse impacts to NASA programs and facilities due to NASA's stringent performance requirements for materials and components related to human-rated space vehicles. Even if a regulation does not directly affect NASA operations, U.S. and international regulations can pose program risks indirectly through requirements levied on manufacturers and vendors of components and materials. For example, manufacturers can change their formulations to comply with new regulatory requirements. Such changes can require time-consuming and costly requalification certification for use in human spaceflight programs. The RRAC PC has implemented a system for proactively managing regulatory change to minimize potential adverse impacts to NASA programs and facilities. This presentation highlights the process utilized by the RRACPC to communicate regulatory change and the associated

  16. Nuclear reactor decommissioning: an analysis of the regulatory environments

    International Nuclear Information System (INIS)

    In the next several decades, the electric utility industry will be faced withthe retirement of 50,000 megawatts (mW) of nuclear capacity. Responsibility for the financial and technical burdens this activity entails has been delegated to the utilities operating the reactors. However, the operators will have to perform the tasks of reactor decommissioning within the regulatory environment dictated by federal, state and local regulations. The purpose of this study was to highlight some of the current and likely trends in regulations and regulatory practices that will significantly affect the costs, technical alternatives and financing schemes encountered by the electric utilities and their customers. To identify significant trends and practices among regulatory bodies and utilities, a reviw of these factors was undertaken at various levels in the regulatory hierarchy. The technical policies were examined in reference to their treatment of allowed technical modes, restoration of the plant site including any specific recognition of the residual radioactivity levels, and planning requirements. The financial policies were examined for specification of acceptable financing arrangements, mechanisms which adjust for changes in the important parameters used to establish the fund, tax and rate-base treatments of the payments to and earnings on the fund, and whether or not escalation and/or discounting were considered in the estimates of decommissioning costs. The attitudes of regulators toward financial risk, the tax treatment of the decommissioning fund, and the time distribution of the technical mode were found to have the greatest effect on the discounted revenue requirements. Under plausible assumptions, the cost of a highly restricted environment is about seven times that of the minimum revenue requirement environment for the plants that must be decommissioned in the next three decades

  17. Responding to the changing regulatory scene

    Energy Technology Data Exchange (ETDEWEB)

    Wise, P.

    1995-12-31

    The regulatory approach of the Illinois Environmental Protection Agency (EPA) is discussed in this paper. Three areas receive emphasis: (1) the changing relations between the US EPA and the states, (2) the new emphasis on pollution prevention techniques, and (3) a new environmental amnesty project. Budgetary considerations, performance partnerships, and nonregulatory compliance assistance are briefly outlined in relation to these topics. Results of the environmental amnesty program for small business, called Clean Break, are briefly reported.

  18. Regulatory Models and the Environment: Practice, Pitfalls, and Prospects

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, K. John; Graham, Judith A.; McKone, Thomas; Whipple, Chris

    2008-06-01

    Computational models support environmental regulatory activities by providing the regulator an ability to evaluate available knowledge, assess alternative regulations, and provide a framework to assess compliance. But all models face inherent uncertainties, because human and natural systems are always more complex and heterogeneous than can be captured in a model. Here we provide a summary discussion of the activities, findings, and recommendations of the National Research Council's Committee on Regulatory Environmental Models, a committee funded by the US Environmental Protection Agency to provide guidance on the use of computational models in the regulatory process. Modeling is a difficult enterprise even outside of the potentially adversarial regulatory environment. The demands grow when the regulatory requirements for accountability, transparency, public accessibility, and technical rigor are added to the challenges. Moreover, models cannot be validated (declared true) but instead should be evaluated with regard to their suitability as tools to address a specific question. The committee concluded that these characteristics make evaluation of a regulatory model more complex than simply comparing measurement data with model results. Evaluation also must balance the need for a model to be accurate with the need for a model to be reproducible, transparent, and useful for the regulatory decision at hand. Meeting these needs requires model evaluation to be applied over the"life cycle" of a regulatory model with an approach that includes different forms of peer review, uncertainty analysis, and extrapolation methods than for non-regulatory models.

  19. The local environmental regulatory regime in China: changes in pro-environment orientation, institutional capacity, and external political support in Guangzhou

    OpenAIRE

    Maria Francesch-Huidobro; Carlos Wing-Hung Lo; Shui-Yan Tang

    2012-01-01

    In the first decade of this millennium China has demonstrated a stronger commitment to environmental protection. Yet, there remains a significant gap between environmental laws and regulations and the quality of the environment. In this paper, we propose an integrated framework for analysis that we apply to investigate the factors that account for this gap in implementation. We analyse the results of surveys conducted in 2000 and 2006 and interviews carried out in 2006 and 2007 in eleven juri...

  20. On regulatory focus and performance in organizational environments

    OpenAIRE

    Beudeker, Dagmar Annemarijn

    2015-01-01

    What motivates people, and when do they perform optimally at work? In this dissertation, a regulatory focus perspective is taken (RFT, Higgins, 1997) to provide answers to these important questions. The results of multiple studies, conducted in complex organizational environments are reported. In many of those environments, there is a clear preference for promotion oriented employees and leaders. Yet, many jobs contain both promotion and prevention tasks. The results show that the use of the ...

  1. Nuclear reactor decommissioning: an analysis of the regulatory environments

    International Nuclear Information System (INIS)

    The purpose of this study is to highlight some of the current and likely regulations that will significantly affect the costs, technical alternatives and financing schemes for reactor decommissioning encountered by electric utilities and their customers. The paper includes a general review of the decommissioning literature, as well as information on specific regulations at the federal, state, and utility levels. Available estimated costs for the decommissioning of individual reactors are also presented. Finally, classification of the specific policies into common trends and practices among the various regulatory bodies is used to examine more general regulatory environments and their potential financial implications

  2. Changes to the International Regulatory Environment

    OpenAIRE

    Mc Hugh, Martin; Mc Caffery, Fergal; Casey, Valentine

    2012-01-01

    Since 2010, two significant international regulations regarding medical device development have come into force, the amendment to the European Union (EU) Medical Device Directive (MDD) 2007/47/EC and the United States (US) Food and Drug Administration (FDA) Final rule on Medical Device Data Systems (MDDS). Adherence to these regulations is mandatory to be able to market a medical device in the respective region. The ability to understand these regulations and apply them to a development proje...

  3. The Policy and Regulatory Environment for Organic Farming in Europe

    OpenAIRE

    Lampkin, N.; Foster, C.; Padel, S.; Midmore, P.

    1999-01-01

    Organic Farming is one of the key issues in reshaping European agricultural policy. This book clarifies the policy and regulatory environment within which organic farming currently operates in all EU-15 member states and in three non-EU countries (Norway, Switzerland and the Czech Republic). European and national regulations and their implementation are reviewed. Focus is led on agri-environmental and mainstream agricultural support measures, marketing and regional development programmes, cer...

  4. Ionizing radiation sources: very diversified means, multiple applications and a changing regulatory environment. Conference proceedings; Les sources de rayonnements ionisants: des moyens tres diversifies, des applications multiples et une reglementation en evolution. Recueil des presentations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-11-15

    This document brings together the available presentations given at the conference organised by the French society of radiation protection about ionizing radiation source means, applications and regulatory environment. Twenty eight presentations (slides) are compiled in this document and deal with: 1 - Overview of sources - some quantitative data from the national inventory of ionizing radiation sources (Yann Billarand, IRSN); 2 - Overview of sources (Jerome Fradin, ASN); 3 - Regulatory framework (Sylvie Rodde, ASN); 4 - Alternatives to Iridium radiography - the case of pressure devices at the manufacturing stage (Henri Walaszek, Cetim; Bruno Kowalski, Welding Institute); 5 - Dosimetric stakes of medical scanner examinations (Jean-Louis Greffe, Charleroi hospital of Medical University); 6 - The removal of ionic smoke detectors (Bruno Charpentier, ASN); 7 - Joint-activity and reciprocal liabilities - Organisation of labour risk prevention in case of companies joint-activity (Paulo Pinto, DGT); 8 - Consideration of gamma-graphic testing in the organization of a unit outage activities (Jean-Gabriel Leonard, EDF); 9 - Radiological risk control at a closed and independent work field (Stephane Sartelet, Areva); 10 - Incidents and accidents status and typology (Pascale Scanff, IRSN); 11 - Regional overview of radiation protection significant events (Philippe Menechal, ASN); 12 - Incident leading to a tritium contamination in and urban area - consequences and experience feedback (Laurence Fusil, CEA); 13 - Experience feedback - loss of sealing of a calibration source (Philippe Mougnard, Areva); 14 - Blocking incident of a {sup 60}Co source (Bruno Delille, Salvarem); 15 - Triggering of gantry's alarm: status of findings (Philippe Prat, Syctom); 16 - Non-medical electric devices: regulatory changes (Sophie Dagois, IRSN; Jerome Fradin, ASN); 17 - Evaluation of the dose equivalent rate in pulsed fields: method proposed by the IRSN and implementation test (Laurent Donadille

  5. Deposit Insurance and Risk Shifting in a Strong Regulatory Environment

    DEFF Research Database (Denmark)

    Bartholdy, Jan; Justesen, Lene Gilje

    This study provides empirical evidence on the moral hazard implications of introducing deposit insurance into a strong regulatory environment. Denmark offers a unique setting because commercial banks and savings banks have different ownership structures, but are subject to the same set of...... regulations. The ownership structure in savings banks implies that they have no incentive to increase risk after the implementation of a deposit insurance scheme whereas commercial banks have. Also, at the time of introduction, Denmark had high capital requirements and a strict closure policy. Using a...

  6. The role of learning environment on high school chemistry students' motivation and self-regulatory processes

    Science.gov (United States)

    Judd, Jeffrey S.

    Changes to the global workforce and technological advancements require graduating high school students to be more autonomous, self-directed, and critical in their thinking. To reflect societal changes, current educational reform has focused on developing more problem-based, collaborative, and student-centered classrooms to promote effective self-regulatory learning strategies, with the goal of helping students adapt to future learning situations and become life-long learners. This study identifies key features that may characterize these "powerful learning environments", which I term "high self-regulating learning environments" for ease of discussion, and examine the environment's role on students' motivation and self-regulatory processes. Using direct observation, surveys, and formal and informal interviews, I identified perceptions, motivations, and self-regulatory strategies of 67 students in my high school chemistry classes as they completed academic tasks in both high and low self-regulating learning environments. With social cognitive theory as a theoretical framework, I then examined how students' beliefs and processes changed after they moved from low to a high self-regulating learning environment. Analyses revealed that key features such as task meaning, utility, complexity, and control appeared to play a role in promoting positive changes in students' motivation and self-regulation. As embedded cases, I also included four students identified as high self-regulating, and four students identified as low self-regulating to examine whether the key features of high and low self-regulating learning environments played a similar role in both groups. Analysis of findings indicates that key features did play a significant role in promoting positive changes in both groups, with high self-regulating students' motivation and self-regulatory strategies generally remaining higher than the low self-regulating students; this was the case in both environments. Findings

  7. Regulatory aspects of management of change - Summary and conclusions

    International Nuclear Information System (INIS)

    Nuclear licensees are increasingly required to adapt to a more challenging commercial environment as moves to de-regulate electricity markets gather pace. One of the costs that is often perceived as being amenable to control is staffing, and hence there is significant exploration of new strategies for managing staffing levels. This report presents the outputs from a Workshop convened by the Special Experts' Group in Human and Organisational Factors (SEGHOF) of the Committee for the Safety of Nuclear Installations (CSNI) and organised by the UK Nuclear Installations Inspectorate (NII). The purpose of the workshop was to facilitate the exchange of views on, and approaches towards, the regulation of organisational change. The major risks associated with organisational change were discussed, and a range of regulatory challenges was identified for detailed discussion. There was agreement that the licensee must retain the responsibility to manage its own business but that organisational issues should be subject to regulatory scrutiny if they have the potential to impact on safety. The regulator should be able to demonstrate an approach to oversight of organisational change which is valid, transparent and consistent, and should inform the licensee of its expectations in terms of information supplied, communication and timing. The workshop confirmed that there is significant agreement between regulators concerning the need for licensees to put in place arrangements to manage organisational change. There was also broad consensus on what should constitute the elements of a licensee's management of change process. Differing views were evident about the balance between regulatory scrutiny of the process, as opposed to the outcomes of change, which largely represents differing regulatory regimes and philosophies. However, it was acknowledged that the regulator must be capable of taking an early view of the adequacy of proposed changes, rather than monitoring outcomes alone

  8. Developing consensus in response to regulatory change: a survival strategy

    International Nuclear Information System (INIS)

    For several years now, the nuclear industry has implemented basic regulatory guides and pursued evolving incremental changes by de facto execution of US Nuclear Regulatory Commission codes or in anticipation of them. The purpose of this paper is to describe a consensus-building process recently employed by industry representatives to respond to changes to 10CFR55, Operator's Licenses and Conforming Amendment. This process resulted from the necessity for industry stakeholders to evaluate the impact of pending regulatory change. It also highlighted the need for more dialogue in the industry and the potential of expanding links with academic representatives. In addition, the paper reports participants; documentation of unnecessary regulatory constraint and vagueness of new terminology and requirements

  9. Changes in the Alpine environment

    Directory of Open Access Journals (Sweden)

    Philippe Schoeneich

    2009-03-01

    Full Text Available L’évolution de l’environnement alpin au XXIe siècle sera conditionnée par le changement climatique. Celui-ci pourrait conduire à des climats inconnus à ce jour dans les Alpes, avec comme conséquence une crise environnementale majeure et durable. Face à ces défis, les financements de recherche restent insuffisants pour la recherche appliquée aux milieux de montagne. Les financements nationaux privilégient souvent la recherche polaire au détriment des hautes altitudes, alors que les financements de type Interreg prennent insuffisamment en compte les besoins de recherche fondamentale, préalable nécessaire à l’élaboration de scénarios. Une évolution se dessine depuis deux ou trois ans vers des projets en réseau à l’échelle alpine. Le présent article fait le point sur les principaux enjeux qui attendent la recherche environnementale alpine et sur la capacité des programmes de recherche à répondre aux besoins. La première partie sur les changements climatiques est fondée sur les rapports récents : rapport de synthèse IPCC 2007 (IPCC 2007, rapport IPCC sur l’Europe (Alcamo et al. 2007, rapport de synthèse du programme ClimChAlp (Prudent-Richard et al., 2008. On y trouvera des bibliographies complètes et circonstanciées. La deuxième partie se base sur une analyse des appels d’offres récents ou en cours, et des projets soumis et financés.The way the Alpine environment will evolve in the 21st century depends upon climate change. This could lead to climates never before seen in the Alps, resulting in a major and lasting environmental crisis. In the face of these challenges, funding is still insufficient for specialised research on mountain environments. State funding often prioritises polar research at the expense of high altitude areas, whereas funding schemes from bodies such as Interreg do not sufficiently address the need for fundamental research, which is nevertheless a necessary first step prior to

  10. Changing Behaviors by Changing the Classroom Environment

    Science.gov (United States)

    Guardino, Caroline A.; Fullerton, Elizabeth

    2010-01-01

    This case study explores the possibility of affecting classroom behaviors by modifying the classroom environment. Although this type of research previously has been conducted in self-contained special education classrooms (Guardino, 2009), this is the first study to explore modifications in an inclusive classroom. The results of this study align…

  11. Climate change consequences for the indoor environment

    NARCIS (Netherlands)

    Ariës, M.B.C.; Bluyssen, P.M.

    2009-01-01

    Scientists warn us about climate change and its effects on the outdoor environment. These effects can have significant consequences for the indoor environment, also in the Netherlands. Climate changes will affect different aspects of the indoor environment as well as the stakeholders of that indoor

  12. Regulatory environment and its impact on the market value of investor-owned electric utilities

    Science.gov (United States)

    Vishwanathan, Raman

    While other regulated industries have one by one been exposed to competitive reform, electric power, for over eighty years, has remained a great monopoly. For all those years, the vertically integrated suppliers of electricity in the United States have been assigned exclusive territorial (consumer) franchises and have been closely regulated. This environment is in the process change because the electric power industry is currently undergoing some dramatic adjustments. Since 1992, a number of states have initiated regulatory reform and are moving to allow retail customers to choose their energy supplier. There has also been a considerable federal government role in encouraging competition in the generation and transmission of electricity. The objective of this research is to investigate the reaction of investors to the prevailing regulatory environment in the electric utility industry by analyzing the market-to-book value for investor-owned electric utilities in the United States as a gauge of investor concern or support for change. In this study, the variable of interest is the market valuation of utilities, as it captures investor confidence to changes in the regulatory environment. Initially a classic regression model is analyzed on the full sample (of the 96 investor-owned utilities for the years 1992 through 1996), providing a total number of 480 (96 firms over 5 years) observations. Later fixed- and random-effects models are analyzed for the same full-sample model specified in the previous analysis. Also, the analysis is carried forward to examine the impact of the size of the utility and its degree of reliability on nuclear power generation on market values. In the period of this study, 1992--1996, the financial security markets downgraded utilities that were still operating in a regulated environment or had a substantial percentage of their power generation from nuclear power plants. It was also found that the financial market was sensitive to the size of

  13. Technological Change and the Environment

    OpenAIRE

    Stavins, Robert; Jaffe, Adam; Newell, Richard

    2000-01-01

    Environmental policy discussions increasingly focus on issues related to technological change. This is partly because the environmental consequences of social activity are frequently affected by the rate and direction of technological change, and partly because environmental policy interventions can themselves create constraints and incentives that have significant effects on the path of technological progress. This paper, prepared as a chapter draft for the forthcoming Handbook of Environmen...

  14. Climate change, environment and allergy.

    Science.gov (United States)

    Behrendt, Heidrun; Ring, Johannes

    2012-01-01

    Climate change with global warming is a physicometeorological fact that, among other aspects, will also affect human health. Apart from cardiovascular and infectious diseases, allergies seem to be at the forefront of the sequelae of climate change. By increasing temperature and concomitant increased CO(2) concentration, plant growth is affected in various ways leading to prolonged pollination periods in the northern hemisphere, as well as to the appearance of neophytes with allergenic properties, e.g. Ambrosia artemisiifolia (ragweed), in Central Europe. Because of the effects of environmental pollutants, which do not only act as irritants to skin and mucous membranes, allergen carriers such as pollen can be altered in the atmosphere and release allergens leading to allergen-containing aerosols in the ambient air. Pollen has been shown not only to be an allergen carrier, but also to release highly active lipid mediators (pollen-associated lipid mediators), which have proinflammatory and immunomodulating effects enhancing the initiation of allergy. Through the effects of climate change in the future, plant growth may be influenced in a way that more, new and altered pollens are produced, which may affect humans. PMID:22433365

  15. MANAGEMENT AND CHANGES IN BUSINESS ENVIRONMENT

    OpenAIRE

    Zoran Jovanoviæ

    2015-01-01

    This study emphasizes the need for managers to promptly and effectively respond to changing business environment. Also, special review on limiting factors in the activities of managers and limiting their ability to anticipate and respond to the challenges of change in the business environment. This study also suggests some ways in which managers and organizations might improve own readiness and flexibility which is needed to respond promptly to business environmental changes. Different types ...

  16. Regulatory changes raise troubling questions for genomic testing

    OpenAIRE

    Evans, Barbara J; Dorschner, Michael O.; Burke, Wylie; Jarvik, Gail P.

    2014-01-01

    By 6 October 2014, many laboratories in the United States must begin honoring new individual data access rights created by recent changes to federal privacy and laboratory regulations. These access rights are more expansive than has been widely understood and pose complex challenges for genomic testing laboratories. This article analyzes regulatory texts and guidances to explore which laboratories are affected. It offers the first published analysis of which parts of the vast trove of data ge...

  17. Changing business environment: implications for farming

    OpenAIRE

    Malcolm, Bill

    2011-01-01

    The natural, technological, economic, political and social environment in which farmers farm constantly changes. History has lessons about change in agriculture and about farmers coping with change, though the future is unknowable and thus always surprising. The implication for farm operation is to prepare, do not predict.

  18. Securing classification and regulatory approval for deepwater projects: management challenges in a global environment

    Energy Technology Data Exchange (ETDEWEB)

    Feijo, Luiz P.; Burton, Gareth C. [American Bureau of Shipping (ABS), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    As the offshore industry continues to develop and move into increasingly deeper waters, technological boundaries are being pushed to new limits. Along with these advances, the design, fabrication and installation of deepwater oil and gas projects has become an increasingly global endeavor. After providing an overview of the history and role of Classification Societies, this paper reviews the challenges of securing classification and regulatory approval in a global environment. Operational, procedural and technological changes which one Classification Society; the American Bureau of Shipping, known as ABS, has implemented to address these challenges are presented. The result of the changes has been a more customized service aiming at faster and more streamlined classification approval process. (author)

  19. Bulgaria's Policy for Regulatory Reform in the European Union : Converging with Europe's Best Regulatory Environments

    OpenAIRE

    World Bank

    2007-01-01

    Bulgaria's entry into the EU Single Market raises new opportunities and new risks for the national economy. As shown in the rest of Europe, a program of regulatory reform offers an effective strategy for managing the risks of more intense competition while preparing Bulgarian companies to prosper within the largest economy in the world. Bulgaria has already made significant progress in reg...

  20. Innovative training techniques in the Canadian nuclear regulatory environment

    International Nuclear Information System (INIS)

    One of the contributors to the safety of nuclear installations is properly-trained personnel. This applies equally to the staff of a regulatory agency, as they are charged with the task of evaluating the safety of installations and operations involving radioactive materials. In 1990, the nuclear regulatory agency of Canada, the Atomic Energy Control Board, set up a Training Center to train AECB staff and to provide assistance to foreign regulatory agencies who had asked for such assistance. In setting up the Training Centre, the authors considered factors which adversely affect the efficacy of training courses. The technical content must, of course, be of sufficiently high quality, but there are other, significant factors which are independent of the content: consider a presentation in which the lecturer shows a slide which is unreadable from the back of the room. The training value of this slide is zero, even though the content may be sound. Pursuing this thought, they decided to examine the mechanics of presentations and the form of training materials, with a view to optimizing their effectiveness in training. The results of this examination were that they decided to use three technologies as the basis for production of training, support and presentation materials. This paper briefly describes these technologies and their advantages. The technologies are: desktop publishing, video and multimedia

  1. Confidential data in a competitive utility environment: A regulatory perspective

    Energy Technology Data Exchange (ETDEWEB)

    Vine, E.

    1996-08-01

    Historically, the electric utility industry has been regarded as one of the most open industries in the United States in sharing information but their reputation is being challenged by competitive energy providers, the general public, regulators, and other stakeholders. As the prospect of competition among electricity power providers has increased in recent years, many utilities have been requesting that the data they submit to their utility regulatory commissions remain confidential. Withholding utility information from the public is likely to have serious and significant policy implications with respect to: (1) consumer education, the pursuit of truth, mutual respect among parties, and social cooperation; (2) the creation of a fair market for competitive energy services; (3) the regulatory balance; (4) regional and national assessments of energy-savings opportunities; (5) research and development; and (6) evaluations of utility programs, plans, and policies. In a telephone survey of all public utility commissions (PUCs) that regulate electric and gas utilities in the U.S., we found that almost all PUCs have received requests from utility companies for data to be filed as confidential, and confidential data filings appear to have increased (both in scope and in frequency) in those states where utility restructuring is being actively discussed. The most common types of data submitted as confidential by utilities dealt with specific customer data, market data, avoided costs, and utility costs.

  2. Strategies for environmental restoration in an evolving regulatory environment

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) is faced with the immense challenge of effectively implementing a program to mitigate and manage the environmental impacts created by past and current operations at its facilities. Such a program must be developed and administered in accordance with the Comprehensive Environmental Response, Compensation and Liability Act and the Resource Conservation and Recovery Act. These regulations are extremely complex, burdening the environmental restoration process with a number of planning and public interaction requirements that must be met before remediation of a site may begin. Existing regulatory and institutional requirements for environmental restoration dictate that extensive planning, characterization and assessment activities be conducted. An important part of the process is the involvement of regulators and the public in the site characterization and assessment activities and in developing reasonable solutions for cleanup. This paper identifies the regulatory requirements and highlights implementation strategies for key aspects of the environmental restoration process for DOE. Trends in legislation and policy relevant to the DOE environmental restoration process are highlighted, with strategies identified for dealing with the evolution of the regulations while maintaining continuity in the technical activities required for cleaning up the DOE hazardous and mixed waste sites. 10 refs

  3. Changes in Cis-regulatory Elements during Morphological Evolution

    Directory of Open Access Journals (Sweden)

    Yu-Lee Paul

    2012-10-01

    Full Text Available How have animals evolved new body designs (morphological evolution? This requires explanations both for simple morphological changes, such as differences in pigmentation and hair patterns between different Drosophila populations and species, and also for more complex changes, such as differences in the forelimbs of mice and bats, and the necks of amphibians and reptiles. The genetic changes and pathways involved in these evolutionary steps require identification. Many, though not all, of these events occur by changes in cis-regulatory (enhancer elements within developmental genes. Enhancers are modular, each affecting expression in only one or a few tissues. Therefore it is possible to add, remove or alter an enhancer without producing changes in multiple tissues, and thereby avoid widespread (pleiotropic deleterious effects. Ideally, for a given step in morphological evolution it is necessary to identify (i the change in phenotype, (ii the changes in gene expression, (iii the DNA region, enhancer or otherwise, affected, (iv the mutation involved, (v the nature of the transcription or other factors that bind to this site. In practice these data are incomplete for most of the published studies upon morphological evolution. Here, the investigations are categorized according to how far these analyses have proceeded.

  4. Risk assessment: A regulatory strategy for stimulating working environment activities?

    DEFF Research Database (Denmark)

    Jensen, Per Langaa

    2001-01-01

    modify this picture by showing how attention has been focussed on physical working environment problems whilst wider psycho-social problems have been ignored. The paper claims there is no evidence from either the quantitative or the qualitative studies that workplace assessment - even though positively...

  5. Legal Research in a Changing Information Environment

    Directory of Open Access Journals (Sweden)

    T du Plessis

    2007-05-01

    Full Text Available Since the advent of the latest constitutional dispensation in South Africa, legal researchers have been presented with new opportunities for research into constitutional issues, development and the relationship between constitutional law and other fields. This article investigates how information technology applications can support the legal research process and what the benefits of technology are likely to be to legal research. Furthermore, it investigates the changes and the impact that electronic resources and the digital information environment might have on legal research. This entails a study of the unique characteristics of digital legal research and of the challenges that legal researchers face in a changing information environment.

  6. Regulatory assessment of risk to the environment: Radiation

    International Nuclear Information System (INIS)

    'Health, Safety and Environment' is a familiar catchphrase in today's government departments, universities and industry. This catchphrase is most often associated with terms such as 'risk assessment', 'risk management' and 'hazard identification'. Such grouping demonstrates the underlying assumption that 'risk(s)' to the environment can be dealt with, and are being dealt with, using the same processes as those used for evaluating health and safety risks. This equally applies when the hazard is radiation. Management of risk to the environment is often carried out within a framework of an Environmental Impact Assessment (EIA) incorporating Risk Assessment (RA) processes. Environmental Management Systems (EMS) and Risk Management Systems (RMS) also provide frameworks which incorporate RA processes. These systems are often integrated with existing quality and safety systems. The steps in these frameworks have been explained and comparisons have been drawn of how an EIA process and Environmental Management System compare with Environmental Risk Management processes. These comparisons demonstrate the common elements of each framework. The Australian Standard for Risk Management (AS/NZS 4360:1999) describes the risk management process in terms of establishing a risk context, identification, analysis, evaluation and treatment of risks. The application of risk management procedures as described in the Australian Standard for Risk Management have been discussed in relation to how they might apply to a simple case scenario of a historical landfill containing radioactive waste. (author)

  7. Climate Change: Science, Health and the Environment

    Centers for Disease Control (CDC) Podcasts

    2007-04-10

    Climate Change: Science, Health and the Environment Howard Frumkin, MD, DrPH, Director of CDC's National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, discusses the science of climate change, the potential for shifts in the natural world to affect our wellbeing, and the challenges of emerging issues in environmental health.  Created: 4/10/2007 by CDC National Center for Environmental Health.   Date Released: 4/13/2007.

  8. University Management in a Changing Environment

    Science.gov (United States)

    Doyle, Peter; Lynch, James E.

    1976-01-01

    The effects of the changing economic and social environment of universities are examined. It is suggested that the next decade will be one of increasing competition between universities and between them and the non-university sector of higher education. Universities will become more market-oriented and more responsive to consumer-students. (LBH)

  9. 77 FR 13258 - Biotechnology Regulatory Services; Changes Regarding the Solicitation of Public Comment for...

    Science.gov (United States)

    2012-03-06

    ... Animal and Plant Health Inspection Service Biotechnology Regulatory Services; Changes Regarding the.... FOR FURTHER INFORMATION CONTACT: Dr. T. Clint Nesbitt, Chief of Staff, Biotechnology Regulatory...://www.aphis.usda.gov/biotechnology/pet_proc_imp.shtml . Current Comment Process for Petitions...

  10. INTELLIGENT ADAPTIVE LEARNING IN A CHANGING ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Guillaume Valentis

    2014-09-01

    Full Text Available In order to develop ever more intelligent and autonomous systems, it is necessary to make them self-learning, since it is impossible to include in their program everything they may encounter during their life-cycle. In this research work, we aim at answering the following: if a system’s environment is modified, how could the system respond to it quickly and appropriately enough? We achieve it by using reinforcement learning to allow the system to rate its decisions, then by developing adaptive learning algorithms for gain and loss rewards. The algorithms include probabilities’ analysis providing to the system ability to adapt its knowledge through time and to respond to a changing environment. Simulations are made for a robot finding its exit in a labyrinth. Results show that reinforcement and adaptive learnings can have many useful applications by offering to a system a reliable possibility of evolution within complex environments in specific situations.

  11. Snapshots of a Changing Scholarly Communications Environment

    Directory of Open Access Journals (Sweden)

    David C. Prosser

    2004-10-01

    Full Text Available Almost two years after the formation of SPARC Europe, the LIBER pre-conference seminar in St Petersburg gave an excellent opportunity to review progress on the road to achieving the aims of SPARC Europe. The traditional models of scholarly communication are increasingly being shown to be antiquated and insufficiently flexible to adapt to the new environment. SPARC Europe calls for far reaching changes in the way we approach scholarly communications. The talks in the seminar provide snapshots of the changing environment. They highlight the activities being taken at all levels by a wide variety of stakeholders in the scholarly communications process: Small and society publishers are developing alternatives to inflexible and restrictive 'Big Deals'; funding bodies and research organisations worldwide are becoming aware of issues surrounding scholarly communication; institutional repositories are providing new communications channels; and libraries are investigating new directions and taking on new roles. This paper will expand on some of these recent developments.

  12. Snapshots of a Changing Scholarly Communications Environment

    OpenAIRE

    Prosser, David C

    2004-01-01

    Almost two years after the formation of SPARC Europe, the LIBER pre-conference seminar in St Petersburg gave an excellent opportunity to review progress on the road to achieving the aims of SPARC Europe. The traditional models of scholarly communication are increasingly being shown to be antiquated and insufficiently flexible to adapt to the new environment. SPARC Europe calls for far reaching changes in the way we approach scholarly communications. The talks in the seminar provide snapshots ...

  13. Cognitive radio: aligning the regulatory environment with the technology, a business case perspective

    NARCIS (Netherlands)

    Anker, P.D.C.; Lemstra, W.

    2012-01-01

    This paper proposes to use the perspective of the business case to deal with the alignment between the introduction of new technology and the regulatory environment. Although this perspective can be used more generally this paper deals with this perspective in the context of the alignment between th

  14. Psychosocial work environment factors and weight change

    DEFF Research Database (Denmark)

    Gram Quist, Helle; Christensen, Ulla; Christensen, Karl Bang;

    2013-01-01

    factors outside the classical work stress models as potential predictors of change in body mass index (BMI) in a population of health care workers. METHODS: A cohort study, with three years follow-up, was conducted among Danish health care workers (3982 women and 152 men). Logistic regression analyses......BACKGROUND: Lifestyle variables may serve as important intermediate factors between psychosocial work environment and health outcomes. Previous studies, focussing on work stress models have shown mixed and weak results in relation to weight change. This study aims to investigate psychosocial...... examined change in BMI (more than +/- 2 kg/m(2)) as predicted by baseline psychosocial work factors (work pace, workload, quality of leadership, influence at work, meaning of work, predictability, commitment, role clarity, and role conflicts) and five covariates (age, cohabitation, physical work demands...

  15. Hypoxia in the changing marine environment

    International Nuclear Information System (INIS)

    The predicted future of the global marine environment, as a combined result of forcing due to climate change (e.g. warming and acidification) and other anthropogenic perturbation (e.g. eutrophication), presents a challenge to the sustainability of ecosystems from tropics to high latitudes. Among the various associated phenomena of ecosystem deterioration, hypoxia can cause serious problems in coastal areas as well as oxygen minimum zones in the open ocean (Diaz and Rosenberg 2008 Science 321 926–9, Stramma et al 2008 Science 320 655–8). The negative impacts of hypoxia include changes in populations of marine organisms, such as large-scale mortality and behavioral responses, as well as variations of species distributions, biodiversity, physiological stress, and other sub-lethal effects (e.g. growth and reproduction). Social and economic activities that are related to services provided by the marine ecosystems, such as tourism and fisheries, can be negatively affected by the aesthetic outcomes as well as perceived or real impacts on seafood quality (STAP 2011 (Washington, DC: Global Environment Facility) p 88). Moreover, low oxygen concentration in marine waters can have considerable feedbacks to other compartments of the Earth system, like the emission of greenhouse gases to the atmosphere, and can affect the global biogeochemical cycles of nutrients and trace elements. It is of critical importance to prediction and adaptation strategies that the key processes of hypoxia in marine environments be precisely determined and understood (cf Zhang et al 2010 Biogeosciences 7 1–24). (synthesis and review)

  16. Hypoxia in the changing marine environment

    Science.gov (United States)

    Zhang, J.; Cowie, G.; Naqvi, S. W. A.

    2013-03-01

    The predicted future of the global marine environment, as a combined result of forcing due to climate change (e.g. warming and acidification) and other anthropogenic perturbation (e.g. eutrophication), presents a challenge to the sustainability of ecosystems from tropics to high latitudes. Among the various associated phenomena of ecosystem deterioration, hypoxia can cause serious problems in coastal areas as well as oxygen minimum zones in the open ocean (Diaz and Rosenberg 2008 Science 321 926-9, Stramma et al 2008 Science 320 655-8). The negative impacts of hypoxia include changes in populations of marine organisms, such as large-scale mortality and behavioral responses, as well as variations of species distributions, biodiversity, physiological stress, and other sub-lethal effects (e.g. growth and reproduction). Social and economic activities that are related to services provided by the marine ecosystems, such as tourism and fisheries, can be negatively affected by the aesthetic outcomes as well as perceived or real impacts on seafood quality (STAP 2011 (Washington, DC: Global Environment Facility) p 88). Moreover, low oxygen concentration in marine waters can have considerable feedbacks to other compartments of the Earth system, like the emission of greenhouse gases to the atmosphere, and can affect the global biogeochemical cycles of nutrients and trace elements. It is of critical importance to prediction and adaptation strategies that the key processes of hypoxia in marine environments be precisely determined and understood (cf Zhang et al 2010 Biogeosciences 7 1-24).

  17. The Relationship between Technological and Regulatory Change in the Communications Industry

    OpenAIRE

    Gregory L. Rosston

    2012-01-01

    Major changes in technology and in regulation led to the proliferation of and willingness to pay for new communication services The changes in technology enabled the changes in regulation, both through the ability to increase supply and quality, but because technological change opened the marketplace to new interest groups influencing regulators and regulation. At the same time, the regulatory system changed to allow and even promoting more competition. Part of the change to the regulatory sy...

  18. Adaptive robot path planning in changing environments

    Energy Technology Data Exchange (ETDEWEB)

    Chen, P.C.

    1994-08-01

    Path planning needs to be fast to facilitate real-time robot programming. Unfortunately, current planning techniques are still too slow to be effective, as they often require several minutes, if not hours of computation. To overcome this difficulty, we present an adaptive algorithm that uses past experience to speed up future performance. It is a learning algorithm suitable for incrementally-changing environments such as those encountered in manufacturing of evolving products and waste-site remediation. The algorithm allows the robot to adapt to its environment by having two experience manipulation schemes: For minor environmental change, we use an object-attached experience abstraction scheme to increase the flexibility of the learned experience; for major environmental change, we use an on-demand experience repair scheme to retain those experiences that remain valid and useful. Using this algorithm, we can effectively reduce the overall robot planning time by re-using the computation result for one task to plan a path for another.

  19. Changing emphasis at the NRC's Office of Nuclear Regulatory Research

    International Nuclear Information System (INIS)

    One of the major objectives of the Office of Research is to ensure availability of sound technical information for timely decision making in support of the NRC's safety mission. The Office of Research is changing some of its emphasis to better meet the expected needs of the NRC's regulatory offices. Long-standing programs in support of operating reactors are nearing completion. These programs include plant aging and severe accident research for currently operating plants. This meeting will also address the new challenges faced by the NRC in its review of the advanced light water and non-light water reactors. As plant aging and severe accident research programs are nearing completion, the research activities are coming to focus on the emerging technologies, for example, digital instrumentation and control systems, both as replacement equipment for operating plants and as the technology of choice and necessity for the advanced reactors. Necessity, because analog equipment is becoming obsolete. Other examples include the use of new materials in operating plants, human factors considerations in the design and operation of the advanced plants, thermal-hydraulic characteristics of the advanced reactors, and new construction techniques

  20. EFFECTS OF CORRUPTION AND REGULATORY ENVIRONMENT ON FOREIGN DIRECT INVESTMENT: A CASE STUDY OF AFRICA

    OpenAIRE

    Rahim M. Quazi

    2014-01-01

    The impact of corruption on foreign direct investment (FDI) inflows has been analyzed by many recent studies. Corruption can either reduce FDI as a grabbing hand by raising uncertainty and transaction costs or facilitate FDI as a helping hand by "greasing" the wheels of commerce in the presence of a weak regulatory environment. Using the Feasible Generalized Least Squares (FGLS) methodology on 1995- 2011 panel data from 53 African countries, this study finds that corruption facilitates FDI in...

  1. An efficient hybrid planner in changing environments

    Energy Technology Data Exchange (ETDEWEB)

    Barbehenn, M.; Hutchinson, S. [Sandia National Labs., Albuquerque, NM (United States)]|[Illinois Univ., Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology; Chen, P.C. [Sandia National Labs., Albuquerque, NM (United States)

    1993-11-01

    In this paper, we present a new hybrid motion planner than is capable of exploiting previous planning episodes when confronted with new planning problems. Our approach is applicable when several (similar) problems are successively posed for the same static environment, or when the environment changes incrementally between planning episodes. At the heart of our system lie two low-level motion planners: a fast, but incomplete planner (which we call LOCAL), and a computationally costly (possibly resolution) complete planner (which we call GLOBAL). When a new planning problem is presented to our planner, a meta-level planner (which we call MANAGER) decomposes the problem into segments that are amenable to solution by LOCAL. This decomposition is made by exploiting a task graph, in which successful planning episodes have been recorded. In cases where the decomposition fails, GLOBAL is invoked. The key to our planner`s success is a novel representation of solution trajectories, in which segments of collision-free paths are associated with the boundary of nearby obstacles.

  2. The changing regulatory climate: How will it impact citizen, industry, and government participation in environmental programs

    Energy Technology Data Exchange (ETDEWEB)

    Facca, G. [IES Utilities, Inc., Cedar Rapids, IA (United States); Arenstein, W. [Writrac Consulting, Iowa City, IA (United States)

    1997-12-31

    This paper will address the future of public and industry participation in environmental regulatory activities, including rule making, permitting, and enforcement/compliance programs. Two aspects of the current regulatory climate will be explored in detail. First, the impacts of the ISO 14000 environmental management standards on the future of auditing and compliance activities will be discussed. Second, the impacts of changes already underway as a result of the current anti-regulatory climate will be summarized. The current anti-regulatory climate has caused air quality regulators to re-think their approaches to stationary, mobile, and indirect source emission reduction programs. These changes are already having an impact on public, industry, and government participation in regulatory programs and enforcement activities. This paper will describe some possible future regulatory scenarios that may occur if these current trends and programs continue.

  3. Natural gas -- The changing competitive environment

    International Nuclear Information System (INIS)

    Owners and senior managers don't have to be reminded that the business is getting tougher. Prices aren't behaving as expected, and they are becoming more volatile. Costs are increasing. The futures market is here to stay, not to mention swaps and options. FERC Order 636 is another complicating factor. Whether you are a producer, marketer, pipeline or an LDC, the structure of the market is changing. The answer to the following questions is quite often -- no: Is your company in a position to offer your customers the services they want? Is your company comfortable using hedges? Do you always know your level of risk? Can your company easily track daily positions and P/L and thoughtfully analyze the various business lines? While not all of the above concerns stem from increased price volatility, Order 636 and complexity resulting from the use of more sophisticated risk control instruments, many of them do. There's a cultural change occurring and companies that want to be market leaders must not just ''learn to live'' with this, but install a management process that thrives in this environment. Understanding the meaning of this goal is the focus of this paper

  4. Changing environments: Coping with diversity and globalization

    International Nuclear Information System (INIS)

    nuclear industry representatives such as WANO and the OECD/NEA should develop a strategic plan to correct this issue. How regulatory authorities should be informed and/or responsible for approving significant organizational change in utilities should be considered by the IAEA and other nuclear organizations to provide consensus guidance in this area

  5. Economies of Density and Regulatory Change in the U.S. Railroad Freight Industry

    OpenAIRE

    Bitzan, John D; Keeler, Theodore E.

    2007-01-01

    Two reform acts, the Staggers Railroad Act of 1980 and the Railroad Revitalization and Regulatory Reform Act of 1976, represented big changes in U.S. policy toward railroads. An important welfare gain from these changes predicted by researchers was the efficiency gain from increased densities in rail freight traffic. However, few retrospective studies have analyzed the accuracy of these predictions. The present paper fills this gap by analyzing the effects of regulatory changes on freight tra...

  6. Receptors rather than signals change in expression in four physiological regulatory networks during evolutionary divergence in threespine stickleback.

    Science.gov (United States)

    Di Poi, Carole; Bélanger, Dominic; Amyot, Marc; Rogers, Sean; Aubin-Horth, Nadia

    2016-07-01

    The molecular mechanisms underlying behavioural evolution following colonization of novel environments are largely unknown. Molecules that interact to control equilibrium within an organism form physiological regulatory networks. It is essential to determine whether particular components of physiological regulatory networks evolve or if the network as a whole is affected in populations diverging in behavioural responses, as this may affect the nature, amplitude and number of impacted traits. We studied the regulation of four physiological regulatory networks in freshwater and marine populations of threespine stickleback raised in a common environment, which were previously characterized as showing evolutionary divergence in behaviour and stress reactivity. We measured nineteen components of these networks (ligands and receptors) using mRNA and monoamine levels in the brain, pituitary and interrenal gland, as well as hormone levels. Freshwater fish showed higher expression in the brain of adrenergic (adrb2a), serotonergic (htr2a) and dopaminergic (DRD2) receptors, but lower expression of the htr2b receptor. Freshwater fish also showed higher expression of the mc2r receptor of the glucocorticoid axis in the interrenals. Collectively, our results suggest that the inheritance of the regulation of these networks may be implicated in the evolution of behaviour and stress reactivity in association with population divergence. Our results also suggest that evolutionary change in freshwater threespine stickleback may be more associated with the expression of specific receptors rather than with global changes of all the measured constituents of the physiological regulatory networks. PMID:27146328

  7. Protection of the environment from ionising radiation in a regulatory context-an overview of the PROTECT coordinated action project

    International Nuclear Information System (INIS)

    The outcome of the PROTECT project (Protection of the Environment from Ionising Radiation in a Regulatory Context) is summarised, focusing on the protection goal and derivation of dose rates which may detrimentally affect wildlife populations. To carry out an impact assessment for radioactive substances, the estimated dose rates produced by assessment tools need to be compared with some form of criteria to judge the level of risk. To do this, appropriate protection goals need to be defined and associated predefined dose rate values, or benchmarks, derived and agreed upon. Previous approaches used to estimate dose rates at which there may be observable changes in populations or individuals are described and discussed, as are more recent derivations of screening benchmarks for use in regulatory frameworks. We have adopted guidance and procedures used for assessment and regulation of other chemical stressors to derive benchmarks. On the basis of consultation with many relevant experts, PROTECT has derived a benchmark screening dose rate, using data on largely reproductive effects to derive species sensitivity distributions, of 10 μGy h-1 which can be used to identify situations which are below regulatory concern with a high degree of confidence.

  8. Regulatory Reform and Productivity Change in Indian Banking

    OpenAIRE

    Casu, Barbara; Ferrari, Alessandra; Zhao, Tianshu

    2013-01-01

    This paper examines the impact of regulatory reform on productivity growth and its components for Indian banks from 1992 to 2009. We estimate parametric and nonparametric efficiency frontiers, followed by Divisia and Malmquist indexes of total factor productivity, respectively. To account for technology heterogeneity among ownership types, we use a metafrontier approach. Results are consistent across methodologies and show sustained productivity growth, driven mainly by technological progress...

  9. Lactic acid bacteria in a changing legislative environment

    NARCIS (Netherlands)

    Feord, J.

    2002-01-01

    The benefits of using lactic acid bacteria in the food chain, both through direct consumption and production of ingredients, are increasingly recognised by the food industry and consumers alike. The regulatory environment surrounding these products is diverse, covering foods and food ingredients, pr

  10. Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.

    Science.gov (United States)

    Indjeian, Vahan B; Kingman, Garrett A; Jones, Felicity C; Guenther, Catherine A; Grimwood, Jane; Schmutz, Jeremy; Myers, Richard M; Kingsley, David M

    2016-01-14

    Changes in bone size and shape are defining features of many vertebrates. Here we use genetic crosses and comparative genomics to identify specific regulatory DNA alterations controlling skeletal evolution. Armor bone-size differences in sticklebacks map to a major effect locus overlapping BMP family member GDF6. Freshwater fish express more GDF6 due in part to a transposon insertion, and transgenic overexpression of GDF6 phenocopies evolutionary changes in armor-plate size. The human GDF6 locus also has undergone distinctive regulatory evolution, including complete loss of an enhancer that is otherwise highly conserved between chimps and other mammals. Functional tests show that the ancestral enhancer drives expression in hindlimbs but not forelimbs, in locations that have been specifically modified during the human transition to bipedalism. Both gain and loss of regulatory elements can localize BMP changes to specific anatomical locations, providing a flexible regulatory basis for evolving species-specific changes in skeletal form. PMID:26774823

  11. Operating the Advanced Test Reactor in today's economic and regulatory environment

    International Nuclear Information System (INIS)

    The Advanced Test Reactor (ATR), located at the Idaho National Engineering and Environmental Laboratory, is the US Department of Energy's largest and most versatile test reactor. Base programs at ATR are planned well into the 21st century. The ATR and support facilities along with an overview of current programs will be reviewed, but the main focus of the presentation will be on the impact that today's economic and regulatory concerns have had on the operation of this test reactor. Today's economic and regulatory concerns have demanded more work be completed at lower cost while increasing the margin of safety. By the beginning of the 1990 s, federal budgets for research generally and particularly for nuclear research had decreased dramatically. Many national needs continued to require testing in the ATR; but demanded lower cost, increased efficiency, improved performance, and an increased margin of safety. At the same time budgets were decreasing, there was an increase in regulatory compliance activity. The new standards imposed higher margins of safety. The new era of greater openness and higher safety standards complemented research demands to work safer, smarter and more efficiently. Several changes were made at the ATR to meet the demands of the sponsors and public. Such changes included some workforce reductions, securing additional program sponsors, upgrading some facilities, dismantling other facilities, and implementing new safety programs. (author)

  12. The changing environment for technological innovation in health care.

    Science.gov (United States)

    Goodman, C S; Gelijns, A C

    1996-01-01

    A distinguishing feature of American health care is its emphasis on advanced technology. Yet today's changing health care environment is overhauling the engine of technological innovation. The rate and direction of technological innovation are affected by a complex of supply- and demandside factors, including biomedical research, education, patent law, regulation, health care payment, tort law, and more. Some distinguishing features of technological innovation in health care are now at increased risk. Regulatory requirements and rising payment hurdles are especially challenging to small technology companies. Closer management of health care delivery and payment, particularly the standardization that may derive from practice guidelines and clamping down on payment for investigational technologies, curtails opportunities for innovation. Levels and distribution of biomedical research funding in government and industry are changing. Financial constraints are limiting the traditional roles of academic health centers in fostering innovation. Despite notable steps in recent years to lower regulatory barriers and speed approvals, especially for products for life-threatening conditions, the Food and Drug Administration is under great pressure from Congress, industry, and patients to do more. Technology gatekeeping is shifting from hundreds of thousands of physicians acting on behalf of their patients to fewer, yet more powerful, managed care organizations and health care networks. Beyond its direct effects on adoption, payment, and use of technologies, the extraordinary buying leverage of these large providers is cutting technology profit margins and heightening competition among technology companies. It is contributing to unprecedented restructuring of the pharmaceutical and medical device industries, leading to unprecedented alliances with generic product companies, health care providers, utilization review companies, and other agents. These industry changes are already

  13. Changing environments: Coping with diversity and globalization

    International Nuclear Information System (INIS)

    It is not surprising that the nuclear community as we know it is becoming more globalized, given that nuclear power has its roots in international cooperation. One only has to go back to the early days, when just over 50 years ago the 'Atoms for Peace' programme was first announced at a plenary meeting of the United Nations General Assembly, to realize that nuclear power really was always a global community. In the years since 1953, we have witnessed the growth of the nuclear industry, which brought with it, among other things: competition between manufacturers from different countries with different design and operating philosophies; individual national cultures and regulatory practices and unique legal systems; and different safety and industrial standards and approaches to technology transfer. Today, the stagnation, or slowdown in construction programmes for nuclear facilities in many countries, combined with the rising costs of R and D, has provided new impetus for the nuclear community to return to a more global outlook. But this new global outlook must grapple with the diversity that grew out of the competition, the individual national cultures, and the unique legal requirements, as well as with the needs of national nuclear industries with different levels of maturity and means. This session will address the new challenges for governments, regulatory authorities, operators, nuclear suppliers, and contractors in facing these and other issues

  14. Estimates of post-closure risk in regulatory decision making: environment agency issues and options

    International Nuclear Information System (INIS)

    The Environment Agency of England and Wales (the Agency) is responsible for the authorization of radioactive waste disposal under the Radioactive Substances Act 1993. British Nuclear Fuels plc (BNFL) is currently authorised to dispose of solid low-level radioactive waste at a disposal facility near the village of Drigg on the Cumbrian coast, in north-west England. In accordance with Government Policy, the Agency periodically reviews authorizations for the disposal of radioactive waste. The Agency intends to commence its next review of the Drigg authorization in 2003/4. To inform its decision making, the Agency required BNFL to submit new safety cases for the Drigg disposal facility in September 2002. These have been received from BNFL and made publicly available (via national public registers): - The Operational Environmental Safety Case considers the impacts of the facility on the environment and the public in the period whilst the site remains operational and under institutional control, which BNFL estimates might be 2150. - The Post-Closure Safety Case considers the long-term environmental impacts of the facility after 2150 and includes a Post-Closure Radiological Safety Assessment, which is a risk assessment. This paper deals with estimates of post-closure risk, it specifically excludes the operational phase and regulatory controls thereon. The paper summarises work undertaken by the Agency to consider potential regulatory actions against different levels of risk in relation to the risk target set out in the published regulatory guidance. The work was undertaken principally in preparation for review of BNFL's Drigg post-closure safety case and authorization. (authors)

  15. Mapping out the regulatory environment and its interaction with land and property markets

    International Nuclear Information System (INIS)

    The purpose of this paper is to explain how the regulatory environment created by planning and building regulations interacts with land and property markets. Since this regulatory environment operates as a form of intervention within property markets in general and the development process in particular, it is essential first to understand the nature, structure and operation of land and property markets. These are covered in the first section. The second section identifies the aims and components of the planning system and building regulations. From this basis, four broad types of policy intervention are reviewed in the third section. These cover policies that seek to shape, regulate or stimulate market activity, and those that aim to build state or market capacity to produce desired outcomes. The final section uses the private residential development process as a case study to explore the extent to which state intervention can influence producer-consumer relationships in one important market sector. The paper argues that effective intervention in land and property markets requires the creation of a broad range of policy tools and their appropriate deployment to suit particular market circumstances. (author)

  16. Mapping out the regulatory environment and its interaction with land and property markets

    International Nuclear Information System (INIS)

    The purpose of this paper is to explain how the regulatory environment created by planning and building regulations interacts with land and property markets. Since this regulatory environment operates as a form of intervention within property markets in general and the development process in particular, it is essential first to understand the nature, structure and operation of land and property markets. These are covered in the first section. The second section identifies the aims and components of the planning system and building regulations. From this basis, four broad types of policy intervention are reviewed in the third section. These cover policies that seek to shape, regulate or stimulate market activity, and those that aim to build state or market capacity to produce desired outcomes. The final section uses the private residential development process as a case study to explore the extent to which state intervention can influence producer-consumer relationships in one important market sector. The paper argues that effective intervention in land and property markets requires the creation of a broad range of policy tools and their appropriate deployment to suit particular market circumstances

  17. How changes in the environment of the nuclear community are challenging the regulators of nuclear safety

    International Nuclear Information System (INIS)

    A country introducing nuclear power in its energy strategy has a lifelong obligation. The obligation is not mainly a question of energy production. It is an obligation to maintain safety during the phase of construction, energy production and decommissioning, as well as to take care of all the waste streams from nuclear installations. In addition, a country introducing nuclear power has an obligation that nuclear sources, material and equipment is used solely for peaceful purposes. In order to protect individuals and the environment, society has decided on legal requirements for the operation of nuclear facilities and established national safety authorities to oversee that the licensees fulfil their obligation and responsibility for safety. The changing environment related to nuclear will most certainly challenge the regulator, thus influencing oversight strategies and inspection practices - change which has started already. The paper addresses some of the changes and regulatory challenges related to this changing environment. (author)

  18. Crisis, criticism, change: Regulatory reform in the wake of nuclear accidents

    International Nuclear Information System (INIS)

    Accidents are a forcing function for change in the nuclear industry. While these events can shed light on needed technical safety reforms, they can also shine a light on needed regulatory system reforms. The TEPCO Fukushima Daiichi nuclear power plant (NPP) accident in Japan is the most recent example of this phenomenon, but it is not the only one. In the wake of the three major accidents that have occurred in the nuclear power industry - Three Mile Island (TMI) in the United States; Chernobyl in Ukraine, in the former Soviet Union; and the Fukushima Daiichi NPP accident in Japan - a commission or committee of experts issued a report (or reports) with harsh criticism of the countries' regulatory system. And each of these accidents prompted changes in the respective regulatory systems. In looking at these responses, however, one must ask if this crisis, criticism, change approach is working and whether regulatory bodies around the world should instead undertake their own systematic reviews, un-prompted by crisis, to better ensure safety. This article will attempt to analyse the issue of regulatory reform in the wake of nuclear accidents by first providing a background in nuclear regulatory systems, looking to international and national legal frameworks. Next, the article will detail a cross-section of current regulatory systems around the world. Following that, the article will analyse the before and after of the regulatory systems in the United States, the Soviet Union and Japan in relation to the TMI, Chernobyl and Fukushima accidents. Finally, taking all this together, the article will address some of the international and national efforts to define exactly what makes a good regulator and provide conclusions on regulatory reform in the wake of nuclear accidents. (author)

  19. The changing environment for US pharmaceuticals.

    Science.gov (United States)

    Meyer, P R

    1994-01-01

    Health reform is currently the predominant health policy issue in the US. It carries profound implications for the pharmaceutical field, including the possibility of price controls that could stifle pharmaceutical research. While policy makers are contemplating alternative approaches to reform, the marketplace for pharmaceuticals has changed dramatically. For example, price increases have lessened, price discounting has increased, and new drugs are typically launched at prices lower than those of the leading product in the therapeutic class. These changes are driven in part by the growth of managed care. Further evidence of change in the industry is the number of job reductions announced and the decline in market valuation of pharmaceutical companies. Policy makers need to take the changed marketplace into consideration as they proceed with health reform, to avoid layering additional policy impediments on top of an increasingly harsh and unforgiving market. Such an approach could seriously compromise incentives for pharmaceutical research. PMID:10155590

  20. Hypoxia in the changing marine environment

    Digital Repository Service at National Institute of Oceanography (India)

    Zhang, J.; Cowie, G.; Naqvi, S.W.A.

    changes in populations of marine organisms, such as large-scale mortality and behavioral responses, as well as variations of species distributions, biodiversity, physiological stress, and other sub-lethal effects (e.g. growth and reproduction). Social...

  1. Counting whales in a challenging, changing environment.

    Science.gov (United States)

    Williams, R; Kelly, N; Boebel, O; Friedlaender, A S; Herr, H; Kock, K-H; Lehnert, L S; Maksym, T; Roberts, J; Scheidat, M; Siebert, U; Brierley, A S

    2014-01-01

    Estimating abundance of Antarctic minke whales is central to the International Whaling Commission's conservation and management work and understanding impacts of climate change on polar marine ecosystems. Detecting abundance trends is problematic, in part because minke whales are frequently sighted within Antarctic sea ice where navigational safety concerns prevent ships from surveying. Using icebreaker-supported helicopters, we conducted aerial surveys across a gradient of ice conditions to estimate minke whale density in the Weddell Sea. The surveys revealed substantial numbers of whales inside the sea ice. The Antarctic summer sea ice is undergoing rapid regional change in annual extent, distribution, and length of ice-covered season. These trends, along with substantial interannual variability in ice conditions, affect the proportion of whales available to be counted by traditional shipboard surveys. The strong association between whales and the dynamic, changing sea ice requires reexamination of the power to detect trends in whale abundance or predict ecosystem responses to climate change. PMID:24622821

  2. 78 FR 42991 - Self-Regulatory Organizations; the Depository Trust Company; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2013-07-18

    ...), 78 FR 33876 (June 5, 2013). II. Description DTC filed the proposed rule change to modify its Rules... COMMISSION Self-Regulatory Organizations; the Depository Trust Company; Order Approving Proposed Rule Change... Limits by Transaction July 12, 2013. I. Introduction On May 17, 2013, The Depository Trust Company...

  3. Performance of a Regulatory Agency as a Function of its Structure and Client Environment: A Simulation Study

    OpenAIRE

    Thompson, W. A.; Vertinsky, I.; D. Kira; F. W. Scharpf

    1982-01-01

    This paper examines some of the interrelationships between the formal organization of a regulatory agency and its task environment. Central to the analysis is the development of a simulation model of a regulatory agency. The model depicts the agency as an hierarchical assemblage of decision units whose overall goal is to satisfy clients without antagonizing competitive interests. The model of the agency incorporates the formal structure of authority, the communication network and the process ...

  4. Principles of assessment of abuse liability: US legal framework and regulatory environment.

    Science.gov (United States)

    Rocha, Beatriz A

    2013-09-01

    Identifying the abuse potential of drug products in the premarketing and postmarketing environment has been a critical component in the implementation of drug abuse control laws worldwide. In the US, the Controlled Substances Act of 1970 (CSA) is a comprehensive federal law enacted to prevent the abuse or diversion of substances with abuse liability or addiction potential (for present purposes, these terms are used interchangeably). Under the jurisdiction of the Drug Enforcement Administration, the law applies to the manufacture and distribution of narcotics and other drug substances with potential of abuse. The CSA classifies substances with abuse potential into schedules I-V based on the substance's risk of diversion or abuse, and thus provides a legal framework for the assessment of abuse liability of New Molecular Entities. When the Food and Drug Administration reviews the safety and efficacy of a New Drug Application it also determines whether the drug has potential for abuse, and if so, will begin the process to schedule the drug under the CSA. As the assessment of abuse potential is a critical component of a marketing application, pharmaceutical companies (sponsors) bear the responsibility of generating a comprehensive preclinical and clinical data package for regulators to review and make decisions on labeling and the corresponding postmarketing surveillance. Recent regulatory guidelines adopted in the European Union (EU) (2006), Canada (2007), and USA (2010) provide recommendations to sponsors on preclinical and clinical methodologies for the assessment of abuse potential. This paper reviews the legal framework of the assessment of abuse liability and scheduling of controlled substances in the USA and describes the current global regulatory environment and the challenges that sponsors and regulators face when assessing abuse liability of New Molecular Entities, from the early stages of development through the late stages, review, and approval. PMID

  5. Layer breeding programmes in changing production environments

    NARCIS (Netherlands)

    LEENSTRA, F.; TEN NAPEL, J.; VISSCHER, J.; VAN SAMBEEK, F.

    2016-01-01

    The housing and management of laying hens and their productivity has gone through enormous developments in the last century. Housing has changed from free-range systems, via battery cages to a variety of loose housing and different types of battery cages, and back to outdoor access systems. Altho

  6. Firms dealing with regulatory change: innovation and political influence strategies

    OpenAIRE

    Wesseling, Joeri; Farla, Jacco; Hekkert, Marko

    2014-01-01

    Firm-level strategies, particularly political strategies, are overlooked in transition studies. Therefore, we study how car manufacturers combine and change their innovation and political influence strategies in response to a technology-forcing regulation that attempts to drive transition. We use Oliver and Holzinger?s (2008) conceptual framework on the case of the zero emission vehicle mandate over the period 1990-2013. We use patent and sales data to operationalize the R&D and commercializa...

  7. The Brazilian Policy on Climate Change: Regulatory and Governance Aspects

    OpenAIRE

    Ronaldo Seroa da Motta

    2012-01-01

    Through the Copenhagen Accord and the Conference of the Parties (COP 16) in Cancun, Brazil has confirmed its national voluntary reduction targets for greenhouse gas (GHG) emissions, with reductions between 36.1 per cent and 38.9 per cent of projected emissions by 2020. These targets were defined in the National Climate Change Policy (PNMC, in Portuguese) approved by the National Congress (Law No. 12.187, dated 29 December 2009). These national targets focus on controlling deforestation, which...

  8. The Environment and Directed Technical Change

    OpenAIRE

    Acemoglu, Daron; Aghion, Philippe; Bursztyn, Leonardo; Hemous, David

    2011-01-01

    This paper introduces endogenous and directed technical change in a growth model with environmental constraints. A unique final good is produced by combining inputs from two sectors. One of these sectors uses “dirty” machines and thus creates environmental degradation. Research can be directed to improving the technology of machines in either sector. We characterize dynamic tax policies that achieve sustainable growth or maximize intertemporal welfare. We show that: (i) in the ...

  9. Counting whales in a challenging, changing environment

    OpenAIRE

    Williams, R.; Kelly, N; Boebel, O.; Friedlaender, A.; Herr, H.; Kock, K.H.; Lehnert, L. S.; Maksym, T.; Roberts, J.; Scheidat, M.; Siebert, U; A. Brierley

    2014-01-01

    Funding: Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme (proposal Nu 253407 (call reference: FP7- PEOPLE-2009-IIF). Estimating abundance of Antarctic minke whales is central to the International Whaling Commission's conservation and management work and understanding impacts of climate change on polar marine ecosystems. Detecting abundance trends is problematic, in part because minke whales are frequently sighted within Antarctic sea ice ...

  10. Changes in FDA enforcement activities following changes in federal administration: the case of regulatory letters released to pharmaceutical companies

    Directory of Open Access Journals (Sweden)

    Nguyen Diane

    2013-01-01

    administration: Clinton (122.3 ± 36.4, Bush (29.5 ± 16.2 and Obama (41.7 ± 11.1. Conclusions Most regulatory letters released by FDA headquarters were related to marketing and advertising activities of pharmaceutical companies. The number of regulatory letters was highest during the second Clinton administration, diminished during the Bush administrations, and increased again during the Obama administration. A further assessment of the impact of changes in federal administration on the enforcement activities of the FDA is required.

  11. Improving the adaptability of simulated evolutionary swarm robots in dynamically changing environments.

    Directory of Open Access Journals (Sweden)

    Yao Yao

    Full Text Available One of the important challenges in the field of evolutionary robotics is the development of systems that can adapt to a changing environment. However, the ability to adapt to unknown and fluctuating environments is not straightforward. Here, we explore the adaptive potential of simulated swarm robots that contain a genomic encoding of a bio-inspired gene regulatory network (GRN. An artificial genome is combined with a flexible agent-based system, representing the activated part of the regulatory network that transduces environmental cues into phenotypic behaviour. Using an artificial life simulation framework that mimics a dynamically changing environment, we show that separating the static from the conditionally active part of the network contributes to a better adaptive behaviour. Furthermore, in contrast with most hitherto developed ANN-based systems that need to re-optimize their complete controller network from scratch each time they are subjected to novel conditions, our system uses its genome to store GRNs whose performance was optimized under a particular environmental condition for a sufficiently long time. When subjected to a new environment, the previous condition-specific GRN might become inactivated, but remains present. This ability to store 'good behaviour' and to disconnect it from the novel rewiring that is essential under a new condition allows faster re-adaptation if any of the previously observed environmental conditions is reencountered. As we show here, applying these evolutionary-based principles leads to accelerated and improved adaptive evolution in a non-stable environment.

  12. The changing winds of atmospheric environment policy

    International Nuclear Information System (INIS)

    Highlights: ► Changes in atmosphere policies over several decades are analysed. ► Direct regulation is less effective and been complemented by other instruments. ► Policy approaches are more complex and integrated and the scale of the issues has evolved. ► The role of stakeholders has grown and the corporate sector has assumed increased responsibility. ► Governance arrangements have become more complex, multilevel and polycentric. -- Abstract: Atmospheric environmental policies have changed considerably over the last several decades. Clearly the relative importance of the various issues has changed over half a century, for example from smoke, sulphur dioxide and photochemical smog being the top priorities to greenhouse gases being the major priority. The traditional policy instrument to control emissions to the atmosphere has been command and control regulation. In many countries this was successful in reducing emissions from point sources, the first generation issues, and to a lesser extent, emissions from mobile and area sources, the second generation issues, although challenges remain in many jurisdictions. However once the simpler, easier, cheaper and obvious targets had been at least partially controlled this form of regulation became less effective. It has been complemented by other instruments including economic instruments, self-regulation, voluntarism and information instruments to address more complex issues including climate change, a third generation issue. Policy approaches to atmospheric environmental issues have become more complex. Policies that directly focus on atmospheric issues have been partially replaced by more integrated approaches that consider multimedia (water, land, etc.) and sustainability issues. Pressures from stakeholders for inclusion, greater transparency and better communication have grown and non-government stakeholders have become increasingly important participants in governance. The scale of the issues has evolved

  13. Nuclear safety regulation in a changing environment

    International Nuclear Information System (INIS)

    The process of privatization and the opening up of the energy market will enhance competition in the energy industry and bring about a far-reaching restructuring in this sector. As a result, major changes in how nuclear power plants are operated may occur, and additional challenges may arise for nuclear safety. Handling these important issues should be subject to international co-operation in the future, inter alia by the IAEA, OECD Nuclear Energy Agency and the relevant bodies of the European Union

  14. The environment and directed technical change: comment

    International Nuclear Information System (INIS)

    This paper discusses the growth model with environmental constraints recently presented in (Acemoglu et al., 2011) which focuses on the redirection of technical change by climate policies with research subsidies and a carbon tax. First, Acemoglu et al.'s model and chosen parameters yield numerical results that do not support the conclusion that ambitious climate policies can be conducted 'without sacrificing (much or any) long-run growth'. Second, they select unrealistic key parameters for carbon sinks and elasticity of substitution. We find that more realistic parameters lead to very different results. Third, the model leads to an unrealistic conclusion when used to analyse endogenous growth, suggesting specification problems. (authors)

  15. Fostering Entrepreneurship in a Changing Business Environment

    Directory of Open Access Journals (Sweden)

    Laurentiu Tachiciu

    2015-02-01

    Full Text Available Entrepreneurship is the cornerstone of a modern competitive economy. Because of the economic and social importance attributed to entrepreneurship, every country has adopted policies aiming to encourage and to support entrepreneurial attitudes and behaviors. Despite the fact that the set of public policy measures is very similar across countries and regions, the outcomes are different. The differences can be observed not only in quantitative terms (i.e. number of newly established ventures, but also in qualitative terms (i.e. proportion of innovative firms, intensity of knowledge and technological level, degree of internationalization etc.. Indeed, entrepreneurship takes different forms ranging from an alternative to employment (self-employed to creation of innovative, competitive and fast growing enterprises. It is also recognized the corporate entrepreneurship, the social entrepreneurship and even the entrepreneurship in the public sector. Different forms of entrepreneurship have a different impact in terms of general progress. Scholars have shown that context is an important factor explaining the variability of entrepreneurship outcomes, calling for a better understanding of the business environment influence on the intensity and quality of the entrepreneurial activity.

  16. Response of Sphagna to the changing environment

    Energy Technology Data Exchange (ETDEWEB)

    Vasander, H. [Helsinki Univ. (Finland). Dept. of Forest Ecology; Jauhiainen, J.; Silvola, J. [Joensuu Univ. (Finland). Dept. of Biology; Karsisto, M. [Finnish Forest Research Inst., Vantaa (Finland)

    1996-12-31

    During last decade, considerable interest has been focused to assess the influence of human activities on ecosystems. The increasing trend in the atmospheric concentration of CO{sub 2} has been predicted to continue till the next century and the amount of nitrogen deposition in the northern hemisphere has increased markedly. Substantial interest has been focused on predicting how these changes will affect on plants. Most boreal mire ecosystems are dominated by mosses of the genus Sphagnum, the litter of which constitutes the main component in the peat deposits and is an important CO{sub 2} sink via peat formation. Since virtually nothing was known about the growth response of peat mosses to elevated concentrations of CO{sub 2} and alerting changes in species composition were detected in the sensitive ombrotrophic mire vegetation under increased N deposition in central Europe, this study was established. Laboratory experiments focused on measurements of the patterns of growth, production and plant metabolism at increased CO{sub 2} and N deposition levels in peat moss species. Long term field experiments were established to study the growth response and spatial competition of two interacting Sphagnum species under the increased nitrogen deposition levels

  17. Controlling risk in a changing environment

    International Nuclear Information System (INIS)

    Competitive pressures in the electric utility industry today demand an unprecedented focus on improving efficiency and cost effectiveness. Work processes and practices that, in some cases, have been in place for years are now being examined and changed in attempts to achieve better results. When such changes are made in nuclear plant work processes, however, the resulting impact on nuclear risk is a potential concern. Two types of risk must be considered: (a) the direct impact of new processes that might inadvertently introduce new safety concerns and (b) the indirect effects on safety due to worker morale and motivation. Work processes and practices at the GPU nuclear stations at Oyster Creek and Three Mile Island (TMI) were developed and put in place in the period following the TMI-2 accident. During this period, great emphasis was placed on installing work processes that attempted to avoid errors through a multiplicity of checks and overchecks. During 1991, GPUN senior management initiated a substantial effort to achieve major improvements in efficiency and effectiveness of key work processes, while maintaining and even enhancing nuclear safety

  18. Efficiency of complex production in changing environment

    Directory of Open Access Journals (Sweden)

    Levanon Erez Y

    2009-01-01

    Full Text Available Abstract Background Cell function necessitates the assemblage of proteins into complexes, a process which requires further regulation on top of the fairly understood mechanisms used to control the transcription and translation of a single protein. However, not much is known about how protein levels are controlled to realize that regulation. Results We integrated data on the composition of yeast protein complexes and the dynamics of their protein building-blocks concentrations to show how the cell regulates protein levels to optimize complex formation. We find that proteins which are subunits of the same complex tend to have similar levels which change similarly following a change in growth conditions, and that abundant proteins undergo larger decrease in their copy number when grown in minimal media. We also study the fluctuations in protein levels and find them to be significantly smaller in large complexes, and in the least abundant subunit of each complex. We use a mathematical model of complex synthesis to explain how all these observations increase the efficiency of complex synthesis, in terms of better utilization of the available molecules and better resilience to stochastic variations. Conclusion In conclusion, these results indicate an intricate regulation at all levels of protein production for the purpose of optimizing complex formation.

  19. 17 CFR 240.19b-4 - Filings with respect to proposed rule changes by self-regulatory organizations.

    Science.gov (United States)

    2010-04-01

    ... organizations. Preliminary Note: A self-regulatory organization also must refer to Form 19b-4 (17 CFR 249.819... paragraph (e), a self-regulatory organization shall submit Form 19b-4(e) (17 CFR 249.820) to the Commission... proposed rule changes by a self-regulatory organization submitted on Form 19b-4 (17 CFR...

  20. Packaging requirements under the new regulatory changes and their effects on the shippers quality control program

    International Nuclear Information System (INIS)

    The Nuclear Regulatory Commission (NRC) has published proposed changes to their current radioactive material transportation regulations (10 CFR Part 71) for comment in the Federal Register. The Department of Transportation (DOT) has also developed changes to their Hazardous Material Regulations dealing with radioactive material. These proposed regulations should soon be published for comment, also in the Federal Register. These regulatory changes are designed to bring the US in line with the international regulations published by the International Atomic Energy Agency (IAEA). Assuming that DOT adopts essentially IAEA regulations, a significant impact of these changes falls in the area of packaging used for the shipment of Low Specific Activity (LSA) material and the new proper shipping category of Surface Contaminated Objects. Since the majority of the shipments made by nuclear power facilities fall into this category, these changes will directly effect the operations of these facilities

  1. Robotic technology applications as a compliance enhancement/facilitation tool in a post-Fukushima regulatory environment

    International Nuclear Information System (INIS)

    The subject matter of the presentation is that of robotic technology applications as a regulatory compliance enhancement/facilitation tool in a post-Fukushima regulatory environment. The term post-Fukushima regulatory environment refers to the fact that all of the upgrade measures that have been issues through the different individual and collective safety review process are considered legally binding. In this regard it should be noted that the post-Fukushima regulatory environment has been shaped by intensive comprehensive nuclear safety review through mechanisms like the EU stress-test review and the Nuclear Energy Institute (NEI) in collaboration with the US Nuclear Regulatory Commission concerning nuclear installations on US soil. Further to this it should be noted that there has been strong collaboration between nuclear energy sector relevant organizations concerning the sharing of knowledge in relation to post-Fukushima safety upgrades on a global level through international conventions channels like the convention on nuclear safety at the extra-ordinary meeting that took place in August of this year.

  2. Changing rice environment in the Philippines

    International Nuclear Information System (INIS)

    The net effects of climate change on rice yields are difficult to predict. Rising carbon dioxide levels in the atmosphere could lead to yield increases whereas atmospheric pollutants could cause yields to decline. Almost nothing is known about the concentration of ozone in the Philippines and in 2001, the authors began to monitor it in Los Banos using automated environmental monitoring system (EMS) that was installed at the IRRI. Samples of air were collected at 3 m height, 1.4 m height, and 0.1 m above the crop canopy. The samples were automatically pumped into the EMS and analyzed for SO2, NO, NOx and O3 concentrations. Hourly mean gas concentrations were recorded for 3 years (2001-2003) on a data logger. This study investigates diurnal and seasonal patterns on real-time concentrations of SO2, NO, NOx, and O3 collected at IRRI. The highest recorded ozone concentrations was 91.4 ppb at noon of 26 Aug 2002. The mean daily (24-hr) concentration of O3 was about 26 ppb. Studies in Europe have shown that such levels can reduce yields by about 20-40%. Ozone concentrations increase with high solar radiation (40 MJ/sq m) and daily maximum temperature (30 deg C). Ozone is produced in a series of reactions involving emissions from motor vehicles mainly in the form of nitrogen oxides. The ozone is related to nitrogen oxide concentration. The observed quantities of NOx in the air depend on motor vehicle emissions, moisture content, and wind direction. The SO2 levels are generally low (10 ppb). Tropospheric pollution appears to be closely linked with the local level of commuter activities

  3. Change in the family food environment is associated with positive dietary change in children

    OpenAIRE

    Hendrie Gilly; Sohonpal Gundeep; Lange Kylie; Golley Rebecca

    2013-01-01

    Abstract Background The family food environment is an important influence in the development of children’s dietary habits. Research suggests that influences of current dietary behaviour and behaviour change may differ. The aims of this paper were to: (1) investigate the association between the food environment at baseline and change in children’s saturated fat intake; and (2) to explore whether a change in the food environment was associated with a change in children’s saturated fat intake. M...

  4. Synthetic fuels and the environment: an environmental and regulatory impacts analysis

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-06-01

    Since July 1979 when DOE/EV-0044 report Environmental Analysis of Synthetic Liquid fuels was published the synthetic fuels program proposals of the Administration have undergone significant modifications. The program year for which the development goal of 1.5 million barrels per day is to be reached has been changed from 1990 to 1995. The program plan is now proposed to have two stages to ensure, among other things, better environmental protection: an initial stage emphasizing applied research and development (R and D), including environmental research, followed by a second stage that would accelerate deployment of those synthetic fuel technologies then judged most ready for rapid deployment and economic operation within the environmental protection requirements. These program changes have significantly expanded the scope of technologies to be considered in this environmental analysis and have increased the likelihood that accelerated environmental R and D efforts will be successful in solving principal environmental and worker safety concerns for most technologies prior to the initiation of the second stage of the accelerated deployment plan. Information is presented under the following section headings: summary; study description; the technologies and their environmental concerns (including, coal liquefaction and gasification, oil shale production, biomass and urban waste conversion); regulatory and institutional analyses; and environmental impacts analysis (including air and water quaility analyses, impacts of carbon dioxide and acid rain, water availability, solid and hazardous wastes, coal mining environmental impacts, transportation issues, community growth and change, and regional impacts). Additional information is presented in seventeen appendixes. (JGB)

  5. 75 FR 8769 - Self-Regulatory Organizations; BATS Exchange, Inc.; Order Approving Proposed Rule Change, as...

    Science.gov (United States)

    2010-02-25

    ... (December 30, 2009), 75 FR 1109 (``Notice''). \\5\\ In Amendment No. 1, the Exchange replaced the bracketed... Release No. 59039 (December 2, 2008), 73 FR 74770 (December 9, 2008) (SR-NYSEArca-2006-21). It is... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Order Approving Proposed Rule Change,...

  6. 78 FR 69694 - Changing Regulatory and Reimbursement Paradigms for Medical Devices in the Treatment of Obesity...

    Science.gov (United States)

    2013-11-20

    ... Gastroenterological Association (AGA) Web site: http://www.gastro.org/education-meetings/live-meetings/aga-fda... Devices in the Treatment of Obesity and Metabolic Diseases: How To Estimate and Reward True Patient... ``Changing Regulatory and Reimbursement Paradigms for Medical Devices in the Treatment of Obesity...

  7. 78 FR 36616 - Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2013-06-18

    ...\\ 17 CFR 240.19b-4. \\3\\ Securities Exchange Act Release No. 69494 (May 2, 2013), 78 FR 26823 (May 8... COMMISSION Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule Change.... On April 22, 2013, The Depository Trust Company (``DTC'') filed with the Securities and...

  8. 75 FR 69150 - Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2010-11-10

    ..., 2010), 75 FR 60158. II. Description DTC's Security Position Report (``SPR'') service provides valuable... COMMISSION Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule Change... November 4, 2010. I. Introduction On September 14, 2010, The Depository Trust Company (``DTC'') filed...

  9. 78 FR 59401 - Self-Regulatory Organizations; ICE Clear Europe Limited; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2013-09-26

    ....19b-4. \\3\\ Securities Exchange Act Release No. 34-70201 (Aug. 14, 2013), 78 FR 51248 (Aug. 20, 2013... Release No. 34-68955 (Feb. 20, 2013), 78 FR 13130 (Feb. 26, 2013) (SR-ICEEU-2012-11). In anticipation of...\\ directs the Commission to approve a proposed rule change of a self-regulatory organization if it...

  10. Working with Policy and Regulatory Factors to Implement Universal Design in the Built Environment: The Australian Experience

    OpenAIRE

    Helen Larkin; Danielle Hitch; Valerie Watchorn; Susan Ang

    2015-01-01

    Built environments that are usable by all provide opportunities for engagement in meaningful occupations. However, enabling them in day to day design processes and practice is problematic for relevant professions. The purpose of this phenomenological study was to gain greater understanding of the policy and regulatory influences that promote or hinder the uptake of universal design in built environments, to inform better future design. Focus groups or telephone interviews were undertaken with...

  11. Strategic Renewal in Regulatory Environments: How inter- and intra-organisational institutional forces influence European incumbent energy firms

    NARCIS (Netherlands)

    M. Stienstra (Marten)

    2008-01-01

    textabstractHow do incumbent firms strategically renew in regulatory environments? Assuming that regulation can both constrain and enable a firm’s strategic renewal opportunities, we investigate how and to what extent incumbent firms undertake exploitative and explorative strategic renewal actions i

  12. Development and Delivery of Coursework: The Legal/Regulatory/Policy Environment of Cyberforensics

    Directory of Open Access Journals (Sweden)

    John W. Bagby

    2006-06-01

    Full Text Available This paper describes a cyber-forensics course that integrates important public policy and legal issues as well as relevant forensic techniques. Cyber-forensics refers to the amalgam of multi-disciplinary activities involved in the identification, gathering, handling, custody, use and security of electronic files and records, involving expertise from the forensic domain, and which produces evidence useful in the proof of facts for both commercial and legal activities. The legal and regulatory environment in which electronic discovery takes place is of critical importance to cyber-forensics experts because the legal process imposes both constraints and opportunities for the effective use of evidence gathered through cyber-forensic techniques. This paper discusses different pedagogies that can be used (including project teams, research and writing assignments, student presentations, case analyses, class activities and participation and examinations, evaluation methods, problem-based learning approaches and critical thinking analysis. A survey and evaluation is provided of the growing body of applicable print and online materials that can be utilized. Target populations for such a course includes students with majors, minors or supporting elective coursework in law, information sciences, information technology, computer science, computer engineering, financial fraud, security and information assurance, forensic aspects of cyber security, privacy, and electronic commerce.

  13. RECENT CHANGES IN THE CLINICAL TRIALS REGULATORY FRAMEWORK IN INDIA; THE ROAD AHEAD FOR AYUSH SECTOR

    Directory of Open Access Journals (Sweden)

    Pradeep Dua

    2013-12-01

    Full Text Available The clinical trials in India are regulated by Schedule ‘Y’ of the Drug and Cosmetics Rules, 1945 which defines the requirements and guidelines for import and/or manufacture of new drugs for sale or for clinical trials. However, owing to the changing International regulatory scenario, increased awareness about the rights/welfare of the trial participants and recent exposure of certain unethical practices being adopted in the conduct of clinical trials in the country, an overhaul of the clinical research related regulatory framework was long overdue. It has also been reported that due to lack of appropriate regulation in clinical trials, India is losing out to Malaysia, China and Singapore. The health ministry’s proposal for a biomedical and health research bill is, therefore, a welcome step. The proposed law intends to ensure compliance with the regulatory provisions and ethical guidelines to ensure well-being of the clinical trial participants.

  14. Development of Regulatory Guide for Risk-Informed Tech. Spec. Changes

    International Nuclear Information System (INIS)

    The policy statement on nuclear safety in 1994 encourages use of probabilistic safety assessment (PSA) for integrated safety evaluation and implementation of risk-informed regulation (RIR) for improving regulatory efficiency. RIR is to use PSA results and other risk insights in regulatory decision-making on the licensing basis change. Korea Institute of Nuclear Safety (KINS) developed the implementation plan and principles of RIR in response to the policy statement. One activity under way is to use PSA in support of decisions to modify an individual plant's technical specifications (TS). TS contain the items in the following specific categories: safety limit and limiting safety system settings, limiting conditions for operation, surveillance requirements, design features, and administrative controls. Typically the proposed risk-informed change to TS involves an extension of allowed outage time (AOT) or surveillance test interval (STI). There are many applications for TS change of which review is completed or under way

  15. The Changing Information Needs of Users in Electronic Information Environments.

    Science.gov (United States)

    Kebede, Gashaw

    2002-01-01

    Focuses on the information needs of users that are changing as a results of changes in the availability of information content in electronic form. Highlights the trend and nature of the physical form in which information content is currently being made available for users' access and use in electronic information environments. (Author/LRW)

  16. Business environment change and decision making mechanism of nuclear generators

    International Nuclear Information System (INIS)

    Change magnitude of business environment for Japanese nuclear generators is significant. It is rapidly growing in the last several years. There are possibilities that the change might impact to management model of nuclear generators. In the paper, the impact to management model, especially, decision making mechanism of the generators is discussed. (author)

  17. From frequent hurricanes to the Deepwater Horizon oil spill in coastal Louisiana: the impact of regulatory change

    Directory of Open Access Journals (Sweden)

    So-Min Cheong

    2014-06-01

    Full Text Available The issue of whether adaptations to past disasters can impede adaptation to new disasters of a different type or intensity will be analyzed by examining the transition from frequent hurricanes to the Deepwater Horizon oil spill in coastal Louisiana. In particular, the effects of changed regulatory structures from the Stafford Act to the Oil Pollution Act of 1990 in response to the Deepwater Horizon oil spill are investigated. The article describes how the federal, state, and local governments adjust. In addition, it illustrates the shifting focus on the environment with the activation of the Oil Pollution Act and the Clean Water Act. It wraps up with a discussion of the uncertainty that is pervasive in the case of the oil spill derived from changed regulations and the novelty of the disaster.

  18. 78 FR 15385 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2013-03-11

    ... Exchange Act Release No. 51759 (May 27, 2005), 70 FR 32860 (June 6, 2005) (SR-Phlx-2004-91). B. Self... COMMISSION Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change To.... Self-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change...

  19. 76 FR 79734 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2011-12-22

    ... the Act. C. Self-Regulatory Organization's Statement on Comments on the Proposed Rule Change Received... COMMISSION Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change Relating to Amending the BOX Trading Rules To Reduce the PIP From One Second to 100 Milliseconds...

  20. 77 FR 51088 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2012-08-23

    .... Self-Regulatory Organization's Statement of the Terms of the Substance of the Proposed Rule Change The...-Regulatory Organization's Statement of the Purpose of, and the Statutory Basis for, the Proposed Rule Change.... See also Securities Exchange Act Release No. 18371 (December 23, 1981), 46 FR 63423 (December 31,...

  1. 75 FR 4438 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2010-01-27

    ...-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In...), 74 FR 1069 (June 4, 2009) (SR-FINRA-2009-016). BX is adopting the new FINRA rule in full and is re... amended. C. Self-Regulatory Organization's Statement on Comments on the Proposed Rule Change Received...

  2. Climate change adaptation of the built environment – an examination

    DEFF Research Database (Denmark)

    Majgaard Krarup, Jonna

    2014-01-01

    In a Danish context, climate changes are primarily manifested in an interaction between modified wind and precipitation patterns, increasing temperature and a rising sea level. The individual factors often act together and are reinforced in interaction with already known natural and cultural...... assess for example a building, and anthropogenic impacts on the environment, also the impact of the environment on installations, and on the human activities must be included in the analysis and assessments. Based on observations and investigations into climate change adaptation in DK and abroad the...... research project, Waterscape (Vandskab), focus on some of the challenges that the architectural disciplines are facing in relation to climate changes adaptation....

  3. The legal and regulatory framework relative to safety and environment in the uranium mines in Niger

    International Nuclear Information System (INIS)

    The mining sector holds an important position in Niger economy. Considerable funds have been invested for the promotion, exploration and exploitation of mineral resources since the colonial period. This has resulted in the discovery of numerous deposits among which are those of uranium. Today, uranium represents more than 3/4 of Niger export revenues. The mining sector is supervised by the Ministry of Mines and Energy. The Ministry applies the mining policy as defined by the government. It elaborates legislative and regulatory texts and sees to their implementation. Regarding uranium, mining activities have been governed since 1961 by various orientation laws and implementation decrees. However, to face up to the harmful consequences on national economy of successive drops of price and sales of its major export product, and taking into account the new international requirements relating to economy globalization and sustainable development, Niger set up a diversification strategy of its mining productions as part of which a new mining code particularly incentive has been established in 1993. The new mining code provides significant advantages to investors. These advantages insure them a great cost effectiveness of their investments in Niger and easy and less onerous respect of regulations regarding safety and protection of environment. Tremendous efforts have been, thus, provided by the IAEA, the Ministry of Mines and Energy and the uranium companies for an optimal protection of workers and the public, especially against the hazards of ionizing radiations. This will to improve the situation has resulted in the adoption of several laws and their application decrees as well as various sectorial laws designed by various Ministry departments concerned with environmental issues and risks prevention. Among these texts are the renewal of the order No 31 M/MH which has defined since 1979 the main axis of the Niger regulations as regards to radioprotection and the design of

  4. Impact of a Fragmented Regulatory Environment on Sustainable Urban Development Design Management

    Directory of Open Access Journals (Sweden)

    Kerry Anne London

    2009-12-01

    Full Text Available The building project development approval process is increasingly complex and fraught with conflict due to the rise of the sustainable urban development movement and inclusive decision making. Coupled with this, government decision-making decentralization has resulted in a fragmented and over-regulated compliance system. Problems arising from the process include wasted resources, excessive time delays, increased holding and litigation costs, inadequate planning coordination, high levels of advocacy costs and a divisive politicized approval process. In Australia, despite attempts by government and industry associations, numerous problems are still unresolved. Design managers increasingly assume a liaison role during the approval phase. There is a long tradition of planning theory literature which provides context for understanding the knowledge-power-participation relationship for this paper. This study investigated the policy, process and practice conflicts during the approval stage in achieving sustainable urban developments. Three regional local government areas within one state jurisdiction and observations from detailed structured focus group interviews involving 23 stakeholders, proposers and assessors were analysed to explore this conflictual environment. As a result of regulatory fragmentation and excessive consultation, various persuasion tactics have been developed by all stakeholders of which `reciprocity' and `authority' were identified as the most common. Two challenges for design managers were thus identified: first, the emergence of the role of a by default central informal arbitrator across conflicting planning instruments; and, second, as a navigator through a set of persuasion tactics. An inclusive knowledge-based design management framework for sustainable urban development is proposed considering Habermas' communicative planning theory, Foucaltian governance and discursive powers thesis and Cialdini's persuasion theory, as

  5. Evaluating model of frozen soil environment change under engineering actions

    Institute of Scientific and Technical Information of China (English)

    WU; Qingbai(吴青柏); ZHU; Yuanlin(朱元林); LIU; Yongzhi(刘永智)

    2002-01-01

    The change of frozen soil environment is evaluated by permafrost thermal stability, thermal thaw sensibility and surface landscape stability and the quantitatively evaluating model of frozen soil environment is proposed in this paper. The evaluating model of frozen soil environment is calculated by 28 ground temperature measurements along Qinghai-Xizang Highway. The relationships of thermal thaw sensibility and freezing and thawing processes and seasonally thawing depth, thermal stability and permafrost table temperature, mean annual ground temperature and seasonally thawing depth, and surface landscape stability and freezing and thawing hazards and their forming possibility are analyzed. The results show that thermal stability, thermal thaw sensibility and surface landscape stability can be used to evaluate and predict the change of frozen soil environment under human engineering action.

  6. Thermo-mechanical study of bare 48Y UF6 containers exposed to the regulatory fire environment

    International Nuclear Information System (INIS)

    Most of the regulatory agencies world-wide require that containers used for the transportation of natural UF6 and depleted UF6 must survive a fully-engulfing fire environment for 30 minutes as described in 10CFR71 and in TS-R-1. The primary objective of this project is to examine the thermo-mechanical performance of 48Y transportation cylinders when exposed to the regulatory hypothetical fire environment without the thermal protection that is currently used for shipments in those countries where required. Several studies have been performed in which UF6 cylinders have been analyzed to determine if the thermal protection currently used on UF6 cylinders of type 48Y is necessary for transport. However, none of them could clearly confirm neither the survival nor the failure of the 48Y cylinder when exposed to the regulatory fire environment without the additional thermal protection. A consortium of five companies that move UF6 is interested in determining if 48Y cylinders can be shipped without the thermal protection that is currently used. Sandia National Laboratories has outlined a comprehensive testing and analysis project to determine if these shipping cylinders are capable of withstanding the regulatory thermal environment without additional thermal protection. Sandia-developed coupled physics codes will be used for the analyses that are planned. A series of destructive and non-destructive tests will be performed to acquire the necessary material and behavior information to benchmark the models and to answer the question about the ability of these containers to survive the fire environment. Both the testing and the analysis phases of this project will consider the state of UF6 under thermal and pressure loads as well as the weakening of the steel container due to the thermal load. Experiments with UF6 are also planned to collect temperature- and pressure-dependent thermophysical properties of this material.

  7. Side Impact Regulatory Trends, Crash Environment and Injury Risk in the USA.

    Science.gov (United States)

    Prasad, Priya; Dalmotas, Dainius; Chouinard, Aline

    2015-11-01

    Light duty vehicles in the US are designed to meet and exceed regulatory standards, self-imposed industry agreements and safety rating tests conducted by NHTSA and IIHS. The evolution of side impact regulation in the US from 1973 to 2015 is discussed in the paper along with two key industry agreements in 2003 affecting design of restraint systems and structures for side impact protection. A combination of all the above influences shows that vehicles in the US are being designed to more demanding and comprehensive requirements than in any other region of the world. The crash environment in the US related to side impacts was defined based on data in the nationally representative crash database NASS. Crash environment factors, including the distribution of cars, light trucks and vans (LTV's), and medium-to-heavy vehicles (MHV's) in the fleet, and the frequency of their interactions with one another in side impacts, were considered. Other factors like, crash severity in terms of closing velocity between two vehicles involved in crash, gender and age of involved drivers in two-vehicle and single vehicle crashes, were also examined. Injury risks in side impacts to drivers and passengers were determined in various circumstances such as near-side, far-side, and single vehicle crashes as a function of crash severity, in terms of estimated closing speed or lateral delta-V. Also injury risks in different pairs of striking and struck cars and LTV's, were estimated. A logistic regression model for studying injury risks in two vehicle crashes was developed. The risk factors included in the model include case and striking vehicles, consisting of cars, SUV's, vans, and pickup trucks, delta-V, damage extent, occupant proximity to the impact side, age and gender of the occupant, and belt use. Results show that car occupants make up the vast majority of serious-to-fatally injured occupants. Injury rates of car occupants in two-vehicle collision are highest when the car is struck by a

  8. Regulatory changes to renewable energy support schemes: An international investment law perspective

    OpenAIRE

    Paleckaite, Gintare

    2014-01-01

    Thesist analyzes how regulatory changes related to renewable energy investment support schemes can be perceived under international investment law standards and how possible decisions of international investment law tribunals could impact investment in this sector. This research is based on case studies of two states: Spain and the Czech Republic and claims against them. These cases will assist in analyzing the effects of the amendment/revocation of renewable energy support schemes. Answers t...

  9. OTC Derivatives: Impacts of Regulatory Changes in the Non-Financial Sector

    OpenAIRE

    Gustavo Silva Araujo; Sérgio Leão

    2015-01-01

    In the aftermath of the 2007-2008 global financial crisis, a series of measures has been proposed to regulate the OTC derivatives market. The motivation is to increase the disclosure of the OTC operations aiming to decrease the probability of crisis. The main objective of this paper is to investigate how regulatory changes in the OTC derivatives market affect the non-financial sector. The Brazilian FX derivatives market provides a natural experiment for the issue: in 2011 the Brazilian govern...

  10. Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes

    OpenAIRE

    Yohko eKitagawa; Naganari eOhkura; Shimon eSakaguchi

    2013-01-01

    Regulatory T (Treg) cells constitute a distinct T cell subset, which plays a key role in immune tolerance and homeostasis. The transcription factor Foxp3 controls a substantial part of Treg cell development and function. Yet its expression alone is insufficient for conferring developmental and functional characteristics of Treg cells. There is accumulating evidence that concurrent induction of Treg-specific epigenetic changes and Foxp3 expression is crucial for lineage specification and funct...

  11. Confronting the Consequences of a Permanent Changing Environment

    Directory of Open Access Journals (Sweden)

    Raluca Ioana Vosloban

    2013-05-01

    Full Text Available Businesses and governments choose how they wish to deal with change. Whether this change is organizational, technological, political, financial etc or even individual pursuing actions as usual is likely to lead to a downward path. The authors of this paper are giving a set of tools for confronting and understanding the consequences of this era of permanent changes by building strengths and seeking opportunities within organizations (private or public and within family (including friends. The work environment and the personal life of the individual have a common point which is adaptability, coping efficiently with changes, a demanded ability of the 3rd millennium human being.

  12. Working with Policy and Regulatory Factors to Implement Universal Design in the Built Environment: The Australian Experience

    Directory of Open Access Journals (Sweden)

    Helen Larkin

    2015-07-01

    Full Text Available Built environments that are usable by all provide opportunities for engagement in meaningful occupations. However, enabling them in day to day design processes and practice is problematic for relevant professions. The purpose of this phenomenological study was to gain greater understanding of the policy and regulatory influences that promote or hinder the uptake of universal design in built environments, to inform better future design. Focus groups or telephone interviews were undertaken with 28 key building industry and disability stakeholders in Australia. Four themes were identified: the difficulties of definition; the push or pull of regulations and policy; the role of formal standards; and, shifting the focus of design thinking. The findings highlight the complexity of working within policy and regulatory contexts when implementing universal design. Occupational therapists working with colleagues from other professions must be aware of these influences, and develop the skills to work with them for successful practice.

  13. Working with Policy and Regulatory Factors to Implement Universal Design in the Built Environment: The Australian Experience.

    Science.gov (United States)

    Larkin, Helen; Hitch, Danielle; Watchorn, Valerie; Ang, Susan

    2015-07-01

    Built environments that are usable by all provide opportunities for engagement in meaningful occupations. However, enabling them in day to day design processes and practice is problematic for relevant professions. The purpose of this phenomenological study was to gain greater understanding of the policy and regulatory influences that promote or hinder the uptake of universal design in built environments, to inform better future design. Focus groups or telephone interviews were undertaken with 28 key building industry and disability stakeholders in Australia. Four themes were identified: the difficulties of definition; the push or pull of regulations and policy; the role of formal standards; and, shifting the focus of design thinking. The findings highlight the complexity of working within policy and regulatory contexts when implementing universal design. Occupational therapists working with colleagues from other professions must be aware of these influences, and develop the skills to work with them for successful practice. PMID:26184278

  14. Fronting Integrated Scientific Web Applications: Design Features and Benefits for Regulatory Environments

    Science.gov (United States)

    Integrated decision support systems for regulatory applications benefit from standardindustry practices such as code reuse, test-driven development, and modularization. Theseapproaches make meeting the federal government’s goals of transparency, efficiency, and quality assurance ...

  15. Impact of independent directors and the regulatory environment on bank merger prices: evidence from takeover activity in the 1990s

    OpenAIRE

    Elijah Brewer; Jackson, William E.; Julapa Jagtiani

    2000-01-01

    This article examines the primary motivation of the bank merger waves in the 1990s. Our investigation of the factors that determine bid premiums paid for target banks focuses on the importance of the financial characteristics of the targets, composition of their boards of directors, and the regulatory environment. ; The value of the target bank to the acquiring bank should reflect its present discounted value of future net cash flows. Thus, at a minimum, the bid price should be a combination ...

  16. Strategic Renewal in Regulatory Environments: How inter- and intra-organisational institutional forces influence European incumbent energy firms

    OpenAIRE

    Stienstra, Marten

    2008-01-01

    textabstractHow do incumbent firms strategically renew in regulatory environments? Assuming that regulation can both constrain and enable a firm’s strategic renewal opportunities, we investigate how and to what extent incumbent firms undertake exploitative and explorative strategic renewal actions in order to remain competitive. Exploitative strategic renewal involves those actions that strengthen or optimise a firm’s current resource deployments, whereas explorative strategic renewal relates...

  17. Workplace learning for information professionals in a changing information environment

    OpenAIRE

    Sacchanand, Chutima

    2000-01-01

    Changes are taking place in society, particularly in higher education. The explosionof knowledge and information technology has virtually altered the characteristics of the learning environment, paving the way for new learning experiences. This is having a dramatic impact on the library and information profession, leading to changes in the continuing education of information professionals. This paper focuses on the role that workplace learning plays in the continuing education of library and...

  18. Sugarcane ethanol: contributions to climate change mitigation and the environment

    OpenAIRE

    Zuurbier, P.J.P.; Vooren, van de, J.

    2008-01-01

    Climate change is a challenge facing human life. It will change mobility and asks for new energy solutions. Bioenergy has gained increased attention as an alternative to fossil fuels. Energy based on renewable sources may offer part of the solution. Bio ethanol based on sugar cane offers advantages to people, the environment and the economy. Not surprisingly, governments currently enact powerful incentives for the development and exploitation of bio ethanol. However, every inch we come closer...

  19. Models for supporting forest management in a changing environment

    OpenAIRE

    Fontes, L.; Bontemps, J.D.; Bugmann, H.; Oijen, van, P.H.; C. Gracia; Kramer, K.; Lindner, M.; Rötzer, T.; Skovsgaard, J. P.

    2010-01-01

    Forests are experiencing an environment that changes much faster than during the past several hundred years. In addition, the abiotic factors determining forest dynamics vary depending on its location. Forest modeling thus faces the new challenge of supporting forest management in the context of environmental change. This review focuses on three types of models that are used in forest management: empirical (EM), process-based (PBM) and hybrid models. Recent approaches may lead to the ap...

  20. Sudden transition and sudden change from open spin environments

    International Nuclear Information System (INIS)

    We investigate the necessary conditions for the existence of sudden transition or sudden change phenomenon for appropriate initial states under dephasing. As illustrative examples, we study the behaviors of quantum correlation dynamics of two noninteracting qubits in independent and common open spin environments, respectively. For the independent environments case, we find that the quantum correlation dynamics is closely related to the Loschmidt echo and the dynamics exhibits a sudden transition from classical to quantum correlation decay. It is also shown that the sudden change phenomenon may occur for the common environment case and stationary quantum discord is found at the high temperature region of the environment. Finally, we investigate the quantum criticality of the open spin environment by exploring the probability distribution of the Loschmidt echo and the scaling transformation behavior of quantum discord, respectively. - Highlights: • Sudden transition or sudden change from open spin baths are studied. • Quantum discord is related to the Loschmidt echo in independent open spin baths. • Steady quantum discord is found in a common open spin bath. • The probability distribution of the Loschmidt echo is analyzed. • The scaling transformation behavior of quantum discord is displayed

  1. Regulatory effect of paraprobiotic Lactobacillus gasseri CP2305 on gut environment and function

    Directory of Open Access Journals (Sweden)

    Tomonori Sugawara

    2016-03-01

    Full Text Available Background: Lactobacillus gasseri CP2305 (CP2305 is a strain of Lactobacillus isolated from a stool sample from a healthy adult that showed beneficial effects on health as a paraprobiotic. In a previous study, we demonstrated that CP2305-fermented heat-treated milk modified gut functions more than artificially acidified sour milk. Thus, the regulatory activity of the former beverage was attributed to the inactivated CP2305 cells. Objective: The aim of this study was to elucidate the contribution of non-viable paraprobiotic CP2305 cells to regulating human gut functions. We thus conducted a randomized, placebo-controlled, double-blinded parallel group trial. Design: The trial included 118 healthy participants with relatively low or high stool frequencies. The test beverage was prepared by adding 1×1010 washed, heat-treated, and dried CP2305 cells directly to the placebo beverage. The participants ingested a bottle of the assigned beverage daily for 3 weeks and answered daily questionnaires about defecation and quality of life. Fecal samples were collected and the fecal characteristics, microbial metabolite contents of the feces and composition of fecal microbiota were evaluated. Results: The number of evacuations and the scores for fecal odors were significantly improved in the group that consumed the CP2305-containing beverage compared with those of the group that consumed the placebo (p=0.035 and p=0.040, respectively. Regarding the fecal contents of microbial metabolites, the level of fecal p-cresol was significantly decreased in the CP2305 group relative to that of the placebo group (p=0.013. The Bifidobacterium content of the intestinal microbiota was significantly increased in the CP2305 group relative to that of the placebo group (p<0.008, whereas the content of Clostridium cluster IV was significantly decreased (p<0.003. The parasympathetic nerve activity of the autonomic nervous system became dominant and the total power of autonomic

  2. Academic Training: Climate change and challenges for the environment / POSTPONED!!!

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 20, 21, 22 June 20, 21, 22 June, from 11:00 to 12:00 – Main Auditorium, bldg. 500 Climate change and challenges for the environment C. SCHLUECHTER / Univ. Bern, CH The Academic Training is postponed.

  3. Sustainable Lifeways: Cultural Persistence in an Ever-Changing Environment

    OpenAIRE

    Monica Ramsey

    2013-01-01

    Book review of Sustainable Lifeways: Cultural Persistence in an Ever-Changing Environment. Naomi F. Miller, Katherine M. Moore, Kathleen Ryan, editors. 2011. University of Pennsylvania Press, Philadelphia. Pp. 352, 73 illustrations. $65.00 (cloth). ISBN 9787934536193.

  4. Sustainable Lifeways: Cultural Persistence in an Ever-Changing Environment

    Directory of Open Access Journals (Sweden)

    Monica Ramsey

    2013-07-01

    Full Text Available Book review of Sustainable Lifeways: Cultural Persistence in an Ever-Changing Environment. Naomi F. Miller, Katherine M. Moore, Kathleen Ryan, editors. 2011. University of Pennsylvania Press, Philadelphia. Pp. 352, 73 illustrations. $65.00 (cloth. ISBN 9787934536193.

  5. The quality of political news in a changing media environment

    NARCIS (Netherlands)

    C.A. Jacobi

    2016-01-01

    What do ongoing changes in the media environment, notably the perceived popularization of news and the shift towards individualized online media, mean for political news quality, both in terms of what it is, as well as how we measure it? This dissertation firstly argues, based on a literature review

  6. The Changing Role of Team Leadership in Multinational Project Environments

    Directory of Open Access Journals (Sweden)

    Hans Thamhain

    2012-11-01

    Full Text Available The influences of business environment and leadership style on team performance are examined in a field study of 37 technology-based projects. The findings provide insight into the changing business environment, as well as the leadership style and organizational conditions most conducive to high project performance in complex multinational project environments. One of the most striking finding is the large number of performance factors associated with the human side. Organizational conditions that satisfy personal and professional needs seem to have a strong effect on collaboration, commitment, risk management, and ultimately overall team performance. The paper provides a framework for assessing leadership effectiveness and suggests conditions favorable for building and managing high-performance project teams in complex, globally dispersed project environments.DOI:10.5585/gep.v3i2.110

  7. An ontological framework for requirement change management in distributed environment

    International Nuclear Information System (INIS)

    Global Software Development (GSD) is getting fame in the software industry gradually. However, in GSD, multiple and diverse stakeholders are involved in the development of complex software systems. GSD introduces several challenges, i.e. physical distance, time zone, culture difference, language barriers. As requirements play a significant role in any software development. The greatest challenge in GSD environment is to maintain a consistent view of the system even if the requirements change. But at the same time single change in the requirement might affect several other modules. In GSD different people use terms and have different ways of expressing the concepts for which people at remote sites are unable to get uniformity regarding the semantics of the terms. In a global environment requires effective communication and coordination. However, to overcome inconsistencies and ambiguities among the team members and to make the team members aware of the consistent view, a shared and common understanding is required. In this paper an approach beneficial to software industry has been proposed, focusing on changing requirements in a Global Software Development environment. A case study has been used for the evaluation of the proposed approach. Therefore, Requirements change management process has been improved by applying the approach of the case study. The proposed approach is beneficial to the software development organizations where frequent changes occur. It guided the software industry to provide the common understandings to all the development teams residing in remote locations. (author)

  8. Crafting the change: the role of job crafting and regulatory focus in adaptation to organizational change

    NARCIS (Netherlands)

    Petrou, P.

    2013-01-01

    Background Organizations change rapidly nowadays. However, little is known about successful ways in which employees can adapt to the new situation that arises throughout organizational change. The present dissertation addressed job crafting as a proactive employee strategy in order to deal with and

  9. Critical perspectives on changing media environments in the Global South

    DEFF Research Database (Denmark)

    Nielsen, Poul Erik

    The main aim of this article is to give a general overview and theoretically discuss how significant changes in the media landscapes in Global South countries alter existing spaces and create new spaces for political and socio-cultural exchange, thus changing the complex interrelationship between...... media and society. Knowing that media is only one of many aspects in current societal changes, the focus will be more on the interrelationship between media and society and less on other aspects like globalization, education and political reforms. At the macro level, the article will discuss how...... the changes in the media landscape continuously alter the power balance between state, civil society and market. At the meso level, these changes will be discussed in relation to the development of the different media and of a variety of new locally specific media environments, which create new spaces...

  10. China's Dilemma: Economic Growth, the Environment and Climate Change

    OpenAIRE

    Woo, Wing Thye; Song, Ligang

    2008-01-01

    China’s Dilemma—Economic Growth, the Environment and Climate Change examines the challenges China will have to confront in order to maintain rapid growth while coping with the global financial turbulence, some rising socially destabilising tensions such as income inequality, an over-exploited environment and the long-term pressures of global warming. China’s Dilemma discusses key questions that will have an impact on China’s growth path and offers some in-depth analyses as to how China co...

  11. Management of radioactive pollutants from front-end nuclear fuel cycle for clean environment - a regulatory approach

    International Nuclear Information System (INIS)

    Front end of Nuclear Fuel Cycle includes mining of low specific active material like uranium and thorium ore, milling of uranium and thorium and fabrication of nuclear fuel assemblies for Nuclear Power Plants. Diverse processes involved in the front-end nuclear fuel cycle lead to handling of wide spectrum of radionuclides. Atomic Energy Regulatory Board (AERB) is entrusted with the responsibility that discharge of the radioactive waste back into the environment does not create any undue hazard to environment and the public. Discharge limits have been prescribed by AERB for front-end fuel cycle facilities such that considering atmospheric, aquatic and terrestrial pathways; the effective dose to members of public does not exceed the yearly limit of 1 mSv. In order to comply with the regulatory limits prescribed by AERB, various treatment measures are adopted by the facilities. For release of conventional pollutants to environment, the limits are prescribed by the State Pollution Control Boards. This paper shall discuss the various treatment procedures adopted by the facilities with respect to radioactivity discharge vis-a-vis the health of the environment around the front-end nuclear fuel cycle facilities. (author)

  12. The DIII-D computing environment: characteristics and recent changes

    International Nuclear Information System (INIS)

    The DIII-D tokamak national fusion research facility along with its predecessor Doublet III has been operating for over 21 years. The DIII-D computing environment consists of: real-time systems controlling the tokamak, heating systems, and diagnostics, and systems acquiring experimental data from instrumentation; major data analysis server nodes performing short term and long term data access and data analysis; and systems providing mechanisms for remote collaboration and the dissemination of information over the world wide web. Computer systems for the facility have undergone incredible changes over the course of time as the computer industry has changed dramatically. Yet there are certain valuable characteristics of the DIII-D computing environment that have been developed over time and have been maintained to this day. Some of these characteristics include: continuous computer infrastructure improvements, distributed data and data access, computing platform integration, and remote collaborations. These characteristics are being carried forward as well as new characteristics resulting from recent changes which have included: a dedicated storage system and a hierarchical storage management system for raw shot data, various further infrastructure improvements including deployment of Fast Ethernet, the introduction of MDSplus, Load Sharing Facility (LSF) and common IDL based graphics tools, and improvements to remote collaboration capabilities. This paper will describe this computing environment, important characteristics that over the years have contributed to the success of DIII-D computing systems, and recent changes to computer systems

  13. Human emotions track changes in the acoustic environment.

    Science.gov (United States)

    Ma, Weiyi; Thompson, William Forde

    2015-11-24

    Emotional responses to biologically significant events are essential for human survival. Do human emotions lawfully track changes in the acoustic environment? Here we report that changes in acoustic attributes that are well known to interact with human emotions in speech and music also trigger systematic emotional responses when they occur in environmental sounds, including sounds of human actions, animal calls, machinery, or natural phenomena, such as wind and rain. Three changes in acoustic attributes known to signal emotional states in speech and music were imposed upon 24 environmental sounds. Evaluations of stimuli indicated that human emotions track such changes in environmental sounds just as they do for speech and music. Such changes not only influenced evaluations of the sounds themselves, they also affected the way accompanying facial expressions were interpreted emotionally. The findings illustrate that human emotions are highly attuned to changes in the acoustic environment, and reignite a discussion of Charles Darwin's hypothesis that speech and music originated from a common emotional signal system based on the imitation and modification of environmental sounds. PMID:26553987

  14. Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson.

    Science.gov (United States)

    Menendez, D; Inga, A; Jordan, J J; Resnick, M A

    2007-04-01

    The p53 master regulatory network provides for the stress-responsive direct control of a vast number of genes in humans that can be grouped into several biological categories including cell-cycle control, apoptosis and DNA repair. Similar to other sequence-specific master regulators, there is a matrix of key components, which provide for variation within the p53 master regulatory network that include p53 itself, target response element sequences (REs) that provide for p53 regulation of target genes, chromatin, accessory proteins and transcription machinery. Changes in any of these can impact the expression of individual genes, groups of genes and the eventual biological responses. The many REs represent the core of the master regulatory network. Since defects or altered expression of p53 are associated with over 50% of all cancers and greater than 90% of p53 mutations are in the sequence-specific DNA-binding domain, it is important to understand the relationship between wild-type or mutant p53 proteins and the target response elements. In the words of the legendary detective Sherlock Holmes, it is 'Elementary, my dear Mr. Watson'. PMID:17401428

  15. The core to regulatory reform

    International Nuclear Information System (INIS)

    Federal Energy Regulatory Commission (FERC) Orders 436, 500, and 636, the Clean Air Act Amendments of 1990, Public Utility Holding Company Act reform, and the 1992 Energy Policy Act all can have significant effects on an LDC's operations. Such changes in an LDC's environments must be balanced by changes within the utility, its marketplace, and its state regulatory environment. The question is where to start. For Columbia Gas Distribution Cos., based in Columbus, OH, the new operating foundation begins with each employee. Internal strength is critical in designing initiatives that meet the needs of the marketplace and are well-received by regulators. Employees must understand not only the regulatory environment in which the LDC operates, but also how their work contributes to a positive regulatory relationship. To achieve this, Columbia initiated the COntinuing Regulatory Education program, or CORE, in 1991. CORE is a regulatory-focused, information-initiative program coordinated by Columbia's Regulatory Policy, Planning, and Government Affairs Department. The CORE programs can take many forms, such as emerging issue discussions, dialogues with regulators and key parties, updates on regulatory fillings, regulatory policy meetings, and formal training classes. The speakers and discussion facilitators can range from human resource department trainers to senior officers, from regulatory department staff members to external experts, or from state commissioners to executives from other LDCs. The goals of CORE initiatives are to: Support a professional level of regulatory expertise through employee participation in well-developed regulatory programs presented by credible experts. Encourage a constructive state regulatory environment founded on communication and cooperation. CORE achieves these goals via five program levels: introductory basics, advanced learning, professional expertise, crossfunctional dialogues, and external idea exchanges

  16. Human activities and climate and environment changes: an inevitable relation

    International Nuclear Information System (INIS)

    The human interference in the environment and the consequent climate change is today a consensus. The climate change can be local, regional and global. The global climate change is mainly caused by the greenhouse gases, and consequently the climate change intervenes in the environment. The interference cycle emerges in several forms and results in several consequences. However, the Global Warming has certainly the most import global impact. The main cause of the increase in the temperature (Greenhouse Effect) is the intensive use of the fossil fuels. Thus, to minimize the climatic changes actions are necessary to reduce, to substitute and to use with more efficient the fossil fuels. Looking at the past, the old agriculturists may have released greenhouse gases since thousand years ago, thus, modifying slowly but in significant form the earth climate much before the Industrial Age. If this theory is confirmed, its consequences would be decisive for the man history in the planet. For example, in parts of the North America and Europe the current temperatures could be even four Celsius degrees smaller. This change in temperature is enough to hinder agricultural used of these regions and consequently to diminish the human development. The main focus of this work is to perform a retrospective in some of civilizations who collapse due to environmental problems and make a historical description of the human activities (agriculture and livestock) since the primordium of the man up to the Industrial Age, aiming at the man interference on the natural dynamics of the global climate and the environment. This work will show through data comparisons and inferences that the gases emissions from these activities had a significant magnitude comparatively by the emissions after the Industrial Age. It is also demonstrated that the climate and environment interference was inevitable because the human evolution was caused by these activities. Another important point of this work is to

  17. Climate change on arctic environment, ecosystem services and society (CLICHE)

    Science.gov (United States)

    Weckström, J.; Korhola, A.; Väliranta, M.; Seppä, H.; Luoto, M.; Tuittila, E.-S.; Leppäranta, M.; Kahilainen, K.; Saarinen, J.; Heikkinen, H.

    2012-04-01

    The predicted climate warming has raised many questions and concerns about its impacts on the environment and society. As a respond to the need of holistic studies comprising both of these areas, The Academy of Finland launched The Finnish Research Programme on Climate Change (FICCA 2011-2014) in spring 2010 with the main aim to focus on the interaction between the environment and society. Ultimately 11 national consortium projects were funded (total budget 12 million EUR). Here we shortly present the main objectives of the largest consortium project "Climate change on arctic environment, ecosystem services and society" (CLICHE). The CLICHE consortium comprises eight interrelated work packages (treeline, diversity, peatlands, snow, lakes, fish, tourism, and traditional livelihoods), each led by a prominent research group and a team leader. The research consortium has three main overall objectives: 1) Investigate, map and model the past, present and future climate change-induced changes in central ecosystems of the European Arctic with unprecedented precision 2) Deepen our understanding of the basic principles of ecosystem and social resilience and dynamics; identify key taxa, structures or processes that clearly indicate impending or realised global change through their loss, occurrence or behaviour, using analogues from the past (e.g. Holocene Thermal Maximum, Medieval Warm Period), experiments, observations and models 3) Develop adaptation and mitigation strategies to minimize the adverse effects of climate change on local communities, traditional livelihoods, fisheries, and tourism industry, and promote sustainable development of local community structures and enhance the quality of life of local human populations. As the project has started only recently no final results are available yet. However, the fieldwork as well as the co-operation between the research teams has thus far been very successful. Thus, the expectations for the final outcome of the project

  18. Global Environments through the Quaternary – Exploring Environmental Change

    Directory of Open Access Journals (Sweden)

    Josie Rose Mills

    2013-07-01

    Full Text Available Born from a series of volumes titled Environmental Change, first printed in 1976, this book is the second edition of a revised history of the global environment published in 2013. It is the collaborative work of David Anderson, Andrew Goudie, and Adrian Parker, all experts in the field of geography, with Parker also having a background in anthropology. Global Environments through the Quaternary provides a general scientific guide to interpreting environmental change. It is aimed at a wide audience and has a full glossary of less well known terms for added clarity. It would be a good accompaniment to a geoarchaeology course or for those interested in the history of environmental fluctuation, with its particular strengths lying in the concise and accessible presentation of scientific data. This enables it to work well as a reference guide that can be used alongside more in-depth research as it provides a key knowledge base with which to formulate personal theories.

  19. Changing the Environment Based on Empowerment as Intrinsic Motivation

    Science.gov (United States)

    Salge, Christoph; Glackin, Cornelius; Polani, Daniel

    2014-05-01

    One aspect of intelligence is the ability to restructure your own environment so that the world you live in becomes more beneficial to you. In this paper we investigate how the information-theoretic measure of agent empowerment can provide a task-independent, intrinsic motivation to restructure the world. We show how changes in embodiment and in the environment change the resulting behaviour of the agent and the artefacts left in the world. For this purpose, we introduce an approximation of the established empowerment formalism based on sparse sampling, which is simpler and significantly faster to compute for deterministic dynamics. Sparse sampling also introduces a degree of randomness into the decision making process, which turns out to beneficial for some cases. We then utilize the measure to generate agent behaviour for different agent embodiments in a Minecraft-inspired three dimensional block world. The paradigmatic results demonstrate that empowerment can be used as a suitable generic intrinsic motivation to not only generate actions in given static environments, as shown in the past, but also to modify existing environmental conditions. In doing so, the emerging strategies to modify an agent's environment turn out to be meaningful to the specific agent capabilities, i.e., de facto to its embodiment.

  20. Changing the Environment Based on Empowerment as Intrinsic Motivation

    Directory of Open Access Journals (Sweden)

    Christoph Salge

    2014-05-01

    Full Text Available One aspect of intelligence is the ability to restructure your own environment so that the world you live in becomes more beneficial to you. In this paper we investigate how the information-theoretic measure of agent empowerment can provide a task-independent, intrinsic motivation to restructure the world. We show how changes in embodiment and in the environment change the resulting behaviour of the agent and the artefacts left in the world. For this purpose, we introduce an approximation of the established empowerment formalism based on sparse sampling, which is simpler and significantly faster to compute for deterministic dynamics. Sparse sampling also introduces a degree of randomness into the decision making process, which turns out to beneficial for some cases. We then utilize the measure to generate agent behaviour for different agent embodiments in a Minecraft-inspired three dimensional block world. The paradigmatic results demonstrate that empowerment can be used as a suitable generic intrinsic motivation to not only generate actions in given static environments, as shown in the past, but also to modify existing environmental conditions. In doing so, the emerging strategies to modify an agent’s environment turn out to be meaningful to the specific agent capabilities, i.e., de facto to its embodiment.

  1. Sustainability of biomass utilisation in changing operational environment - SUBICHOE

    Energy Technology Data Exchange (ETDEWEB)

    Soimakallio, S. [VTT Technical Research Centre of Finland, Espoo (Finland)], email: sampo.soimakallio@vtt.fi

    2012-07-01

    The main objective of the project was to assist in strategic decision-making of public administration and companies, as regards the most sustainable use of biomass, by taking into account the changing operational environment. This project continued the work of the BIOVAIKU project by exploring in more details the most critical issues identified in sustainability assessment. These include the need to develop assessment methods and criteria in particular for land use and land-use change due to biomass cultivation and harvesting and indirect impacts due to resource competition.

  2. Postprandial changes in the exhalation of radon from the environment

    International Nuclear Information System (INIS)

    The exhalation of radon originally inhaled from the home environment and dissolved in body fluids and tissues has been studied serially for periods of several hours in six persons. The observation of a pronounced postprandial peak in the rate of exhalation of radon shows that the similar peak observed in the exhalation of radon produced from radium in vivo results from the flushing of a reservoir in soft tissue and not from a change in the fraction lost from bone

  3. Recreation and tourism induced changes in northern boreal environments

    OpenAIRE

    Kangas, K. (Katja)

    2009-01-01

    Abstract The popularity of nature-based tourism has increased worldwide and peripheral areas with conservational value, like protected areas, are attractive destinations. The recreational use and construction of tourism facilities can cause environmental degradation and decrease the conservational and recreational value of areas if not well planned and managed. The aim of this thesis was to improve our knowledge of recreation and tourism induced changes in northern boreal environments. Dir...

  4. The Role Of Labour Unions In A Changing World Environment

    OpenAIRE

    Jones, Peter W

    2004-01-01

    Trade unions have been important institutions of industrial society; they have helped deliver significant outcomes in terms of improved living standards, equity and justice to workers all over the world. However, at the end of the twentieth century, unions face a situation marked by the universal trend towards greater liberalization of economic and political regimes. The changing environment requires new approaches and strategies on the part of unions if they are to remain major social actors...

  5. 76 FR 65565 - Expansion of Fagatele Bay National Marine Sanctuary, Regulatory Changes, and Sanctuary Name Change

    Science.gov (United States)

    2011-10-21

    ... longline fishery in 2001; mass coral bleaching events in 1994, 2002, and 2003; and nonpoint source... period in February and March of 2009 (74 FR 5641) to identify issues and gauge interest within American... April 26, 1986 (51 FR 15878). The proposed changes would: 1. Modify the name of the sanctuary...

  6. 75 FR 53010 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NASDAQ OMX PHLX, Inc...

    Science.gov (United States)

    2010-08-30

    ... COMMISSION Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NASDAQ OMX PHLX, Inc... proposed rule change from interested persons. \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self...'' or ``Commission'') the proposed rule change as described in Items I and II below, which Items...

  7. 78 FR 1281 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2013-01-08

    ...-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change ICE Clear Europe... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In its filing... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change A...

  8. 78 FR 28680 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Withdrawal of Proposed Rule Change...

    Science.gov (United States)

    2013-05-15

    ..., 2013), 78 FR 18646 (Mar. 27, 2013). On May 7, 2013, ICC withdrew the proposed rule change (SR-ICC-2013... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Withdrawal of Proposed Rule Change... Securities Exchange Act of 1934 \\1\\ and Rule 19b-4 thereunder,\\2\\ a proposed rule change relating...

  9. 75 FR 34196 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by EDGX Exchange, Inc...

    Science.gov (United States)

    2010-06-16

    ... Organization's Statement of the Terms of Substance of the Proposed Rule Change EDGX proposes to make changes to...-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change 1... Exchange Release No. 61698 (March 12, 2010), 75 FR 13151 (March 18, 2010) (approving File Nos. 10-194...

  10. 77 FR 69525 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2012-11-19

    ... Organization's Statement of the Terms of Substance of the Proposed Rule Change The Exchange proposes to amend... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In its filing...-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change...

  11. 75 FR 34189 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by EDGA Exchange, Inc...

    Science.gov (United States)

    2010-06-16

    ... Organization's Statement of the Terms of Substance of the Proposed Rule Change EDGA proposes to make changes to...-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change 1... Exchange Release No. 61698 (March 12, 2010), 75 FR 13151 (March 18, 2010) (approving File Nos. 10-194...

  12. 76 FR 40415 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2011-07-08

    ... Organization's Statement of the Terms of Substance of the Proposed Rule Change The Exchange, pursuant to... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In its filing...-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change...

  13. 77 FR 7652 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Proposed Rule Change To Revise...

    Science.gov (United States)

    2012-02-13

    ... COMMISSION Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Proposed Rule Change To Revise... Europe Limited (``ICE Clear Europe'') filed with the Securities and Exchange Commission (``Commission... changes described below with its Clearing Members. These changes seek to improve drafting and...

  14. Changing Water Environment in the Greater Jakarta Basins

    Science.gov (United States)

    Pawitan, H.; Delinom, R.; Lubis, R. F.

    2014-12-01

    Recent rapid economic development in the greater Jakarta areas has caused not only increased water resources demands but also affects the water environment due to population increase and land use changes, that further causes land degradation, and changes in hydrologic regimes and environmental qualities. In the present study, the water environmental capacities as indicated by the changing landscapes in the greater Jakarta basins were investigated to understand the role of land use management and its impact on water resources, ecosystem and environmental services. The Ciliwung river basin where rapid population increases and progresses of the land use/cover changes occurring was selected as a representative basin, and 41 water samplings were taken at different time of Jan. 08, Apr. 08, Jul. 08, and Oct. 08 during 2009 to understand the effect of rainfall variation on water quality, and clarify the characteristics of hydrological cycle. Landuse changes of the upper basins as can be seen for the upper basin indicated the expansion of settlements during 1990 to 2004 from 4.1% to 17.6% or in acreage increased almost five times, not only converting forested area, but mostly taking place from paddy fields that contributed about 50% of the additional land for new settlements. Urbanization expanding around the greater Jakarta basins, is closely related to the increased fluctuations of river discharges in recent years, with recurrence floods quickly after heavy rainfall events. Furthermore, the study results indicated that water quality of Ciliwung river, especially the loading concentrations of nitric acid closely reflects the population densities of the watershed. These results suggest that the land use/cover changes of the greater Jakarta basins affect largely the change of water environment of the areas and resulting a deteriorated factor for water resources, ecosystems and environmental services in both of quantity and quality

  15. Environment Changes of Lampao Dam Communities in Northeast Thailand

    Directory of Open Access Journals (Sweden)

    Winyoo Sata

    2008-01-01

    Full Text Available Problem statement: The objective of this research was to study the environment change of Lampao Dam communities in Northeast Thailand, being a case study of the Sa-Adnathom community, Lamklong sub-district, Muang, Kalasin province, adjacent to the Lampao Dam. Approach: A qualitative research, it started with a review of literature and related researches. Field data were collected by way of interviews and both participant and non-participant observations, involving 15 informants including senior-villagers, who had lived in the village some 10-20 years. The research data were descriptively analyzed and presented. Results: As a result its was found that the Lampao Dam communities date back 200 years to the era of Chiangsom Kingdom. Deserted due to deadly epidemics, the area was later on repopulated by migrants from Yang Talad district, Kalasin province. A new community, called Sa-Adnathom, was born. Prior to the inception of the National Plan for Social and Economic Development in 1961, the environment of this community was complete with fertile land and natural resource abundance. People lived in harmony with nature and relied on resources from it for their livelihood, especially from Nong Waeng reservoir, Phan and Yang streams and Khoke Ngoo forest. But with the implementation of the first Plan for Social and Economic Development in 1961-1966 the Thai government started the construction of the Lampao Dam in 1963. Completed in 1968, the Dam took land from the villagers, part of which were simply flooded. This forced the village farmers to change their means of livelihood from relying on forest and rivers to production methods which by necessity involved purchase of machines and usage of chemical fertilizers. In short, a change from farming to fishing in Lampao Dam. Their values also changed from local exchanges of goods to money economy, which only led to household debts, increasing with rising degree of consumerism. Eventually people in the

  16. Speculative Fictions for Understanding Global Change Environments: Two Thought Experiments

    Directory of Open Access Journals (Sweden)

    Noel Gough

    2003-03-01

    Full Text Available The purpose of a thought experiment, as the term was used by quantum and relativity physicists in the early part of the twentieth century, was not prediction (as is the goal of classical experimental science, but more defensible representations of present ‘realities’. Speculative fictions, from Mary Shelley's Frankenstein to the Star Wars cinema saga, can be read as sociotechnical thought experiments that produce alternative representations of present circumstances and uncertainties, and anticipate and critique possible futures. In this essay I demonstrate how two examples of popular speculative fictions, Frank Herbert's Dune (1965 and Ursula Le Guin's The Telling (2000, function as thought experiments that problematise global transitions in their respective eras. I argue that critical readings of such stories can help us to anticipate, critique, and respond constructively to social and cultural changes and change environments within nation-states that constitute, and are constituted by, global change processes and their effects.

  17. Change in the family food environment is associated with positive dietary change in children

    Directory of Open Access Journals (Sweden)

    Hendrie Gilly

    2013-01-01

    Full Text Available Abstract Background The family food environment is an important influence in the development of children’s dietary habits. Research suggests that influences of current dietary behaviour and behaviour change may differ. The aims of this paper were to: (1 investigate the association between the food environment at baseline and change in children’s saturated fat intake; and (2 to explore whether a change in the food environment was associated with a change in children’s saturated fat intake. Method Secondary analysis of a 12 week cluster randomised controlled trial in 133 4-13 year old children. Families were randomly allocated to parental education regarding changing to reduced-fat dairy foods or a comparison non-dietary behaviour. The interventions were family focused. Parents received education from a dietitian in 3x30minute sessions to facilitate behaviour change. Parents completed a comprehensive questionnaire capturing three domains of the food environment – Parent knowledge and attitudes; shaping practices; and behaviours and role modelling. Children’s dietary intake was assessed via multiple 24-hour recalls at baseline and week 12. Changes in the family food environment and primary outcome (saturated fat were calculated. Hierarchical linear regression models were performed to explore the association between baseline and change in food environment constructs and change in saturated fat intake. Standardised Beta are presented (p Results After adjustments for child and family demographics, higher levels of perceived food availability (β=-0.2 at baseline was associated with greater reduction in saturated fat intake, where as higher perceived responsibility (β=0.2, restriction (β=0.3 and pressure to eat (β=0.3 were associated with lesser change in saturated fat. An increase in nutrition knowledge (β=-0.2, perceived responsibility (β=-0.3 and restriction (β=-0.3 from baseline to week 12 were associated with greater reduction in

  18. Reactors licensing: proposal of an integrated quality and environment regulatory structure for nuclear research reactors in Brazil

    International Nuclear Information System (INIS)

    A new integrated regulatory structure based on quality and integrated issues has been proposed to be implemented on the licensing process of nuclear research reactors in Brazil. The study starts with a literature review about the licensing process in several countries, all of them members of the International Atomic Energy Agency. After this phase it is performed a comparative study with the Brazilian licensing process to identify good practices (positive aspects), the gaps on it and to propose an approach of an integrated quality and environmental management system, in order to contribute with a new licensing process scheme in Brazil. The literature review considered the following research nuclear reactors: Jules-Horowitz and OSIRIS (France), Hanaro (Korea), Maples 1 and 2 (Canada), OPAL (Australia), Pallas (Holand), ETRR-2 (Egypt) and IEA-R1 (Brazil). The current nuclear research reactors licensing process in Brazil is conducted by two regulatory bodies: the Brazilian National Nuclear Energy Commission (CNEN) and the Brazilian Institute of Environment and Renewable Natural Resources (IBAMA). CNEN is responsible by nuclear issues, while IBAMA by environmental one. To support the study it was applied a questionnaire and interviews based on the current regulatory structure to four nuclear research reactors in Brazil. Nowadays, the nuclear research reactor’s licensing process, in Brazil, has six phases and the environmental licensing process has three phases. A correlation study among these phases leads to a proposal of a new quality and environmental integrated licensing structure with four harmonized phases, hence reducing potential delays in this process. (author)

  19. Persistent Robotic Tasks: Monitoring and Sweeping in Changing Environments

    CERN Document Server

    Smith, Stephen L; Rus, Daniela

    2011-01-01

    We present controllers that enable mobile robots to persistently monitor or sweep a changing environment. The changing environment is modeled as a field which grows in locations that are not within range of a robot, and decreases in locations that are within range of a robot. We assume that the robots travel on given closed paths. The speed of each robot along its path is controlled to prevent the field from growing unbounded at any location. We consider the space of speed controllers that can be parametrized by a finite set of basis functions. For a single robot, we develop a linear program that is guaranteed to compute a speed controller in this space to keep the field bounded, if such a controller exists. Another linear program is then derived whose solution is the speed controller that minimizes the maximum field value over the environment. We extend our linear program formulation to develop a multi-robot controller that keeps the field bounded. The multi-robot controller has the unique feature that it do...

  20. Leading change to create a healthy and satisfying work environment.

    Science.gov (United States)

    Sanders, Carolyn L; Krugman, Mary; Schloffman, Danielle H

    2013-01-01

    Nurse executives must take a leadership role in creating a healthy work environment for nurses and all disciplines. Engaging in partnerships and empowering clinical nurses to construct the solutions to barriers that may stand in the way of the goal of a satisfied and healthy workforce are important strategies toward success. This publication outlines many projects a 3-time Magnet-designated academic hospital has implemented, working with our shared leadership councils, to meet the standards for a healthy work environment. These initiatives, from the unit to the hospital level, included standardizing a culture change of uninterrupted meal breaks, the creation of intensive care unit Zen rooms, strategies to better manage increased patient volumes, best practices for facility design, enhancing physician-nurse relations, and a hospital wellness program. Data were benchmarked against national nurse and employee surveys to compare progress and report outcomes. Two important nursing organization structures that have contributed to the success of a healthy and satisfied nursing work environment include UEXCEL, a longstanding clinical nurse professional practice program, and the hospital's 11-year participation in the University HealthSystem Consortium/American Association of Colleges of Nursing National Post-Baccalaureate Nurse Residency Program. A highly engaged, well-educated, and committed nursing workforce, nurtured by a strong leadership team, has created a positive work environment characterized by low turnover and high retention. PMID:24022289

  1. Sustainability of Biomass Utilisation in Changing operational Environment - SUBICHOE

    Energy Technology Data Exchange (ETDEWEB)

    Soimakallio, S.; Hongisto, M.; Koponen, K. (VTT Technical Research Centre of Finland, Espoo (Finland)), e-mail: sampo.soimakallio@vtt.fi (and others)

    2011-11-15

    Sustainability is a multi-faceted and challenging target, but at the same time a crucial issue to assess when setting policies and targets for the future. The main objective of the SUBICHOE project is to assist public administration and companies in strategic decision- making in the most sustainable use of biomass, by taking into account the changing operational environment. The project aimed to assess how the sustainability criteria, in particular those set by the EC, ensure the sustainability of biofuels from short and long term perspectives. The project is carried out jointly by VTT Technical Research Centre of Finland, Finnish Environment Institute SYKE, MTT Agrifood Research Finland, Finnish Forest Research Institute (Metla) and The Government Institute for Economic Research (VATT). The work plan of the project is divided into four Work Packages. In this article, a summary of main findings of the project is presented. (orig.)

  2. Academic Training: Climate change and challenges for the environment

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2005-2006 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 14, 15, 16 November from 11:00 to 12:00 - TH Auditorium, bldg. 4 Climate change and challenges for the environment by C. Schlüchter / Institut für Geologie, Univ. Bern, CH Climate change as seen by a geologist Glaciers are an integrated part of the high altitudes and the high latitudes of our planet. They are sensitive to temperature and moisture changes and adjust their mass balances accordingly. By doing so they interact with their substratum, the geological basement and they produce characteristic imprints of their presence, their variability and their disappearance. In glacial geology and paleoglaciology such imprints of former glaciers are carefully recorded, mapped and, hopefully, dated in order to obtain amplitude and periodicity records of their changes - as forced by changing climate, as we believe. In the upcoming lectures three aspects will be discussed: the last glaciation in the Swiss Alps. A reconstruction is shown based on fieldwor...

  3. Climate change, living environment and ways of life

    International Nuclear Information System (INIS)

    The research project 'Climate Change, Living Environment and Way of Life' is focused on the social concepts of risks and of proposed policies related to global environmental problems as seen by representatives of various social groups. Drawing on the social-scientific methodology and applying its concept apparatus, the research project focuses on two central problems in the field of contemporary environmental research. Firstly, with the way in which environmental problems influence people's values and attitudes. Secondly, with the question of how people seek to act and to show solidarity towards new generations by means of environmental policies or by protecting nature within the framework of their private ways of life

  4. Constitutive versus responsive gene expression strategies for growth in changing environments.

    Directory of Open Access Journals (Sweden)

    Nico Geisel

    Full Text Available Microbes respond to changing environments by adjusting gene expression levels to the demand for the corresponding proteins. Adjusting protein levels is slow, consequently cells may reach the optimal protein level only by a time when the demand changed again. It is therefore not a priori clear whether expression "on demand" is always the optimal strategy. Indeed, many genes are constitutively expressed at intermediate levels, which represents a permanent cost but provides an immediate benefit when the protein is needed. Which are the conditions that select for a responsive or a constitutive expression strategy, what determines the optimal constitutive expression level in a changing environment, and how is the fitness of the two strategies affected by gene expression noise? Based on an established model of the lac- and gal-operon expression dynamics, we study the fitness of a constitutive and a responsive expression strategy in time-varying environments. We find that the optimal constitutive expression level differs from the average demand for the gene product and from the average optimal expression level; depending on the shape of the growth rate function, the optimal expression level either provides intermediate fitness in all environments, or maximizes fitness in only one of them. We find that constitutive expression can provide higher fitness than responsive expression even when regulatory machinery comes at no cost, and we determine the minimal response rate necessary for "expression on demand" to confer a benefit. Environmental and inter-cellular noise favor the responsive strategy while reducing fitness of the constitutive one. Our results show the interplay between the demand-frequency for a gene product, the genetic response rate, and the fitness, and address important questions on the evolution of gene regulation. Some of our predictions agree with recent yeast high throughput data, for others we propose the experiments that are needed

  5. 76 FR 38712 - Self-Regulatory Organizations; BATS Exchange, Inc.; Order Approving a Proposed Rule Change To...

    Science.gov (United States)

    2011-07-01

    ... (May 12, 2011); 76 FR 28830 (``Notice''). II. Description First, the Exchange proposes to change its... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Order Approving a Proposed Rule Change To Amend BATS Rule 11.9, Entitled ``Orders and Modifiers'' and BATS Rule 11.13, Entitled ``Order...

  6. 77 FR 829 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2012-01-06

    ... COMMISSION Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change... proposed rule change from interested persons. \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self... based on the MSCI EM Index. See Securities Exchange Act Release Nos. 44900 (October 25, 2001) 66...

  7. 75 FR 4129 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2010-01-26

    ... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In its filing...-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change 1... 27, 2009), 74 FR 106 (June 4, 2009) (SR-FINRA-2009-016). BX is adopting the new FINRA rule in...

  8. 75 FR 80553 - Self-Regulatory Organizations; NYSE Amex LLC; Order Approving a Proposed Rule Change Relating to...

    Science.gov (United States)

    2010-12-22

    ... Securities Exchange Act Release No. 63187 (October 27, 2010), 75 FR 67424 (``Notice''). II. Description of... COMMISSION Self-Regulatory Organizations; NYSE Amex LLC; Order Approving a Proposed Rule Change Relating to... rule change to: (i) Add to Rule 900.3NY(h) a definition of ``Stock/Complex Order;'' (ii) revise...

  9. 75 FR 2899 - Self-Regulatory Organizations; New York Stock Exchange LLC; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2010-01-19

    ...), 74 FR 64797 (hereinafter referred to as ``Notice''). II. Description of the Proposal The Exchange... COMMISSION Self-Regulatory Organizations; New York Stock Exchange LLC; Order Approving Proposed Rule Change...\\ and Rule 19b-4 thereunder,\\2\\ a proposed rule change ] amending its maximum fee for...

  10. 75 FR 48391 - Self-Regulatory Organizations; NASDAQ OMX PHLX, Inc.; Order Approving a Proposed Rule Change...

    Science.gov (United States)

    2010-08-10

    ... FR 38583 (``Notice''). In its proposal, Phlx proposed to establish fees for direct 10Gb circuit... COMMISSION Self-Regulatory Organizations; NASDAQ OMX PHLX, Inc.; Order Approving a Proposed Rule Change...,\\2\\ a proposed rule change to establish pricing for 10Gb direct circuit connections and...

  11. 78 FR 5518 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2013-01-25

    ... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change 1. Purpose The..., 2009), 74 FR 26750 (June 3, 2009) (SR-Phlx-2009-32) (approval order regarding current electronic... COMMISSION Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

  12. 77 FR 13668 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2012-03-07

    .... I. Self-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change 1. Purpose The...: \\4\\ See Securities Exchange Act Release No. 62776 (August 26, 2010), 75 FR 53727 (September 1,...

  13. 75 FR 48390 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Order Approving a Proposed Rule Change...

    Science.gov (United States)

    2010-08-10

    ... FR 38571 (``Notice''). In its proposal, BX proposed to establish fees for direct 10Gb circuit... COMMISSION Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Order Approving a Proposed Rule Change...,\\2\\ a proposed rule change to establish pricing for 10Gb direct circuit connections and...

  14. 75 FR 65541 - Self-Regulatory Organizations; Order Approving Proposed Rule Change by NASDAQ OMX PHLX, Inc. To...

    Science.gov (United States)

    2010-10-25

    ... Exchange Act Release No. 62799 (August 25, 2010), 75 FR 54662 (``Notice''). The Exchange proposes to amend... COMMISSION Self-Regulatory Organizations; Order Approving Proposed Rule Change by NASDAQ OMX PHLX, Inc. To...\\ a proposed rule change to expand the Exchange's $.50 Strike Price Program (``$0.50 Strike...

  15. 78 FR 11705 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2013-02-19

    ... Organization's Statement of the Terms of Substance of the Proposed Rule Change The Exchange is filing with the.... Commentary: .01-.02 No change. * * * * * II. Self-Regulatory Organization's Statement of the Purpose of, and... options trading. \\7\\ See Securities Exchange Act Release No. 49785 (May 28, 2004), 69 FR 32090 (June...

  16. 76 FR 10418 - Self-Regulatory Organizations; NASDAQ Stock Market, LLC; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2011-02-24

    ... COMMISSION Self-Regulatory Organizations; NASDAQ Stock Market, LLC; Notice of Filing of Proposed Rule Change... February 8, 2011, The NASDAQ Stock Market LLC (``NASDAQ'' or ``Exchange'') filed with the Securities and... Change The NASDAQ Stock Market LLC proposes to amend the By-Laws of its parent corporation, The...

  17. 77 FR 47138 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing of Proposed Rule Change Amending...

    Science.gov (United States)

    2012-08-07

    ... Members' Schedule of NYSE Amex Options LLC in Order To Reflect Changes to the Capital Structure of the...-regulatory organization. The Commission is publishing this notice to solicit comments on the proposed rule... Organization's Statement of the Terms of Substance of the Proposed Rule Change The Exchange proposes to...

  18. The evolutionary dynamics of integrons in changing environments.

    Science.gov (United States)

    Engelstädter, Jan; Harms, Klaus; Johnsen, Pål J

    2016-06-01

    Integrons are genetic elements that are common in bacteria and are hotspots for genome evolution. They facilitate the acquisition and reassembly of gene cassettes encoding a variety of functions, including drug resistance. Despite their importance in clinical settings, the selective forces responsible for the evolution and maintenance of integrons are poorly understood. We present a mathematical model of integron evolution within bacterial populations subject to fluctuating antibiotic exposures. Bacteria carrying a functional integrase that mediates reshuffling of cassette genes and thereby modulates gene expression patterns compete with bacteria without a functional integrase. Our results indicate that for a wide range of parameters, the functional integrase can be stably maintained in the population despite substantial fitness costs. This selective advantage arises because gene-cassette shuffling generates genetic diversity, thus enabling the population to respond rapidly to changing selective pressures. We also show that horizontal gene transfer promotes stable maintenance of the integrase and can also lead to de novo assembly of integrons. Our model generates testable predictions for integron evolution, including loss of functional integrases in stable environments and selection for intermediate gene-shuffling rates in changing environments. Our results highlight the need for experimental studies of integron population biology. PMID:26849314

  19. Improving the Assessment and Valuation of Climate Change Impacts for Policy and Regulatory Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Marten, Alex; Kopp, Robert E.; Shouse, Kate C.; Griffiths, Charles; Hodson, Elke L.; Kopits, Elizabeth; Mignone, Bryan K.; Moore, Chris; Newbold, Steve; Waldhoff, Stephanie T.; Wolverton, Ann

    2013-04-01

    The social cost of carbon (SCC) is a monetized metric for evaluating the benefits associated with marginal reductions in carbon dioxide (CO2) emissions. It represents the expected welfare loss from the future damages caused by the release of one tonne of CO2 in a given year, expressed in consumption equivalent terms. It is intended to be a comprehensive measure, taking into account changes in agricultural productivity, human health risks, loss of ecosystem services and biodiversity, and the frequency and severity of flooding and storms, among other possible impacts. Estimating the SCC requires long-term modeling of global economic activity, the climate system, and the linkages between the two through anthropogenic greenhouse gas (GHG) emissions and the effects of changing climatic conditions on economic activity and human well-being. The United States government currently uses the SCC in regulatory benefit-cost analyses to assess the welfare effects of changes in CO2 emissions. Consistent application of the SCC to federal rulemaking analyses began in 2009-2010 with the development of a set of global SCC estimates that employed three prominent integrated assessment models (IAMs) -- DICE, FUND, and PAGE. The U.S. government report identified a number of limitations associated with SCC estimates in general and its own assumptions in particular: an incomplete treatment of damages, including potential “catastrophic” impacts; uncertainty regarding the extrapolation of damage functions to high temperatures; incomplete treatment of adaptation and technological change; and the evaluation of uncertain outcomes in a risk-neutral fashion. External experts have identified other potential issues, including how best to model long-term socio-economic and emissions pathways, oversimplified physical climate and carbon cycle modeling within the IAMs, and an inconsistency between non-constant economic growth scenarios and constant discount rates. The U.S. government has committed

  20. Changes seen in the environment report from Uusimaa Regional Environment Centre

    International Nuclear Information System (INIS)

    This publication describes the environmental changes and the influencing factors occurring within the administrative regions of the Uusimaa Regional Environment Centre. The quality of the environment can be judged as satisfying in regards to both the mental and physical health of humans. Areas have a steady trend of a relatively high growth in population density, while the efficiency of land use in new settlements is low. Traffic and the travel distances are on the rise. A considerable part of the population lives in areas where the noise standards are violated, despite control measures. Waste management, water distribution and sewage networks are under continuous development. In regards to the nature, the situation in some parts is of great concern. The manifold of the nature, cultural landscapes and culturally valuable buildings and sites are threatened. The living space of flora and fauna is continuing to decrease and change. The risks caused by human activities in groundwater areas are increasing. For these reasons the implementation of protection programs is important. Emissions from point sources to the water and air have significantly decreased. Yet, the impacts of air quality deprivation can still be seen in some cities and in the vicinity of some industrial sites. The eutrophication have essentially changed the ecology and fishstocks; however, the water quality has improved in many places. Regarding the above issues, as well as some other topics, included in the report are 16 theme maps 66 pictures. However, the report states that the monitoring and reporting of the environmental quality should be improved. (orig.)

  1. Passive sampling in regulatory chemical monitoring of nonpolar organic compounds in the aquatic environment

    NARCIS (Netherlands)

    Booij, K.; Robinson, C.D.; Burgess, R.M.; Mayer, P.; Roberts, C.A.; Ahrens, L.; Allan, I.J.; Brant, J.; Jones, L.; Kraus, U.R.; Larsen, M.M.; Lepom, P.; Petersen, J.; Pröfrock, D.; Roose, P.; Schäfer, S.; Smedes, F.; Tixier, C.; Vorkamp, K.; Whitehouse, P.

    2016-01-01

    We reviewed compliance monitoring requirements in the EuropeanUnion, the United States, and the Oslo-Paris Convention for the protection of themarine environment of the North-East Atlantic, and evaluated if these are met bypassive sampling methods for nonpolar compounds. The strengths andshortcoming

  2. Passive Sampling in Regulatory Chemical Monitoring of Nonpolar Organic Compounds in the Aquatic Environment

    Science.gov (United States)

    We reviewed compliance monitoring requirements in the European Union (EU), the United States(USA), and the Oslo-Paris Convention for the protection of the marine environment of the North-East Atlantic (OSPAR), and evaluated if these are met by passive sampling methods for nonpola...

  3. The Role of Learning Environment on High School Chemistry Students' Motivation and Self-Regulatory Processes

    Science.gov (United States)

    Judd, Jeffrey S.

    2009-01-01

    Changes to the global workforce and technological advancements require graduating high school students to be more autonomous, self-directed, and critical in their thinking. To reflect societal changes, current educational reform has focused on developing more problem-based, collaborative, and student-centered classrooms to promote effective…

  4. OMV Gas and Power - Adapting to the Changing Environment

    International Nuclear Information System (INIS)

    Full text: The energy market environment is currently changing, long term growth of gas and power is expected. Key drivers for this assumption is further electrification, CO2 regulations and increased liquidity of gas and power markets. Power generation in OECD Europe drives the gas demand increase. European import dependency shapes the gas infrastructure development as Europe is the largest net gas importer, domestic production is decreasing and the link between Southeastern and Caspian supply regions will increase flexibility. OMV is adapting its business portfolio based on the changing energy map. Creation of energy hubs, new development of combining CO2 capture technologies with EOR and EGR, and strengthening E and P and Gas and Power in terms of investments will change the portfolio. On top, OMV invests in gas fired and renewable power generation assets. Conversion from gas to power enables the optimization of gas and power assets in OMV's core markets. Building up a balanced portfolio of power plants in terms of fuel and markets will create additional value to OMV and a reduction of the CO2 footprint. The flexibility of gas fired power plants and renewable assets fit well together. Overview on the status quo of OMV's power plant projects: CCPP Brazi/Romania, CCPP Samsun/Turkey, CCPP Haiming/Germany, windpower Dorobantu/Romania, Heat Recovery Plant Weitendorf/Austria. (author)

  5. An Enabling Regulatory Environment for Sustainable Investment: The Example of Trade Law

    OpenAIRE

    Bürgi, Elisabeth

    2014-01-01

    There is broad international agreement that investment flows to the agricultural sector in developing countries need to be increased. But there is also agreement that such investments need to be sustainable. For being sustainable, they must not only be beneficial to the public economy, but also to rural households and to the environment in the short and the long run. Whether sustainable investments take place, not least depends on the legal framework within which these investments are situate...

  6. Passive Sampling in Regulatory Chemical Monitoring of Nonpolar Organic Compounds in the Aquatic Environment

    OpenAIRE

    Booij, Kees; Robinson, Craig D.; Burgess, Robert M.; Mayer, Philipp; Roberts, Cindy A; Ahrens, Lutz; Allan, Ian J; Brant, Jan; Jones, Lisa; Kraus, Uta R.; Larsen, Martin M.; Lepom, Peter; Petersen, Jördis; Pröfrock, Daniel; Roose, Patrick

    2016-01-01

    We reviewed compliance monitoring requirements in the European Union, the United States, and the Oslo-Paris Convention for the protection of the marine environment of the North-East Atlantic, and evaluated if these are met by passive sampling methods for nonpolar compounds. The strengths and shortcomings of passive sampling are assessed for water, sediments, and biota. Passive water sampling is a suitable technique for measuring concentrations of freely dissolved compounds. This method yields...

  7. Academic Training: Climate change and challenges for the environment / POSTPONED!!!

    CERN Multimedia

    Françoise benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 20, 21, 22 June 20, 21, 22 June, from 11:00 to 12:00 - Main Auditorium, bldg. 500 Climate change and challenges for the environment C. SCHLUECHTER / Univ. Bern, CH The seminar is postponed. ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.

  8. Sustainability of biomass utilisation in changing operational environment - SUBICHOE

    Energy Technology Data Exchange (ETDEWEB)

    Soimakallio, S.; Hongisto, M.; Koponen, K.; Sokka, L. (VTT Technical Research Centre of Finland, Espoo (Finland)), Email: sampo.soimakallio@vtt.fi; Antikainen, R.; Manninen, K. (Finnish Environment Inst. SYKE, Helsinki (Finland)); Thun, R.; Sinkko, T. (MTT Agrifood Research Finland, Jokioinen (Finland)); Pasanen, K. (Finnish Forest Research Inst., Joensuu (Finland))

    2010-10-15

    Sustaibability is a multi-faceted and challenging target, but at the same time a crucial issue to assess when setting policies and targets for the future. The main objective of the SUBICHOE project is to assist in strategic decision- making of public administration and companies, as regards the most sustainable use of biomass, by taking into account the changing operational environment. In the project the sustainability of biofuels and the criteria, in particular those set by the EC, for ensuring that set requirements can and will be fulfilled are being assessed from short and long term perspectives. The project is carried out jointly by VTT Technical Research Centre of Finland, Finnish Environment Institute SYKE, MTT Agrifood Research Finland, Finnish Forest Research Institute (Metla) and The Government Institute for Economic Research (VATT). The project started in June 2009 and it is scheduled to be finalised in June 2011. The work plan of the project is divided into four Work Packages. In this article, a summary of a critical view on the requirements and challenges related to the implementation of the RES Directive is also provided based on the main findings of the WP1. (orig.)

  9. Computer simulations of a generic truck cask in a regulatory fire using the Container Analysis Fire Environment (CAFE) code

    International Nuclear Information System (INIS)

    The Container Analysis Fire Environment (CAFE) computer code is designed to predict accurately convection and radiation heat transfer to a thermally massive object engulfed in a large pool fire. It is well suited for design and risk analyses of spent nuclear fuel transport systems. CAFE employs computational fluid dynamics and several fire and radiation models. These models must be benchmarked using experimental results. In this paper, a set of wind velocity conditions are determined which allow CAFE accurately to reproduce recent heat transfer measurements for a thick walled calorimeter in a ST-1 regulatory pool fire. CAFE is then used to predict the response of an intack (thin walled) generic legal weight truck cask. The maximum temperatures reached by internal components are within safe limits. A simple 800 deg. C, grey-radiation fire model gives maximum component temperatures that are somewhat below those predicted by CAFE. (author)

  10. An assessment of the contribution of NRC [Nuclear Regulatory Commission] regulatory growth to nuclear plant cost growth using engineering scope changes

    International Nuclear Information System (INIS)

    The purpose of this study is to determine the contribution of NRC regulations to the growth in nuclear power plant capital costs using the case study method. The two plants selected for the case studies are Florida Power and Light Company's (FP and L) St. Lucie Unit 1 (SL1) and St. Lucie Unit 2 (SL2). SL1 was constructed in the early 1970s and was granted an operating license in 1976. SL2 was constructed in the late 1970s and early 1980s, and was granted an operating license in 1983. The information bases were the amendments to the contracts between FP and L and its architect-engineer/constructor, i.e., the ''scope changes''. These were examined and analyzed for causation, i.e., NRC-initiated or utility-initiated, and all of the costs associated with scope changes of each type were aggregated to determine the contribution of each. Although the scope changes accounted for only a small fraction of the total cost growth for either plant, they were still used to determine the relative contribution of regulatory growth to cost growth. Unexpectedly, a significantly higher percentage of out-of-scope work (approximately 84%) was attributable to NRC regulatory requirements for SL1 than SL2 (approximately 47%). These results were unexpected because SL2 was constructed during a period in which regulation was considered to be particularly unstable. However, a more detailed analysis of causation indicates that a shift occurred from an ad-hoc mode of regulation in the early 1970s to a more prescriptive process in the late 1970s. Thus the number of formal NRC requirements may not be a valid measure of regulatory stability

  11. Private Higher Educational Institutions in a changing South African environment

    Directory of Open Access Journals (Sweden)

    L. Froneman

    2002-12-01

    Full Text Available One of the problems experienced by potential learners is accessibility to education facilities, especially in rural areas and for people with time constraints. The objective of this research is to investigate the role for Private Higher Educational Institutions (PHEIs in South Africa, sharing the task of providing education with government supported institutions. Although distance learning is not a panacea for all educational problems, it holds great promise for driving change in education. The research is based on questionnaires, interviews and literature. Results indicated that traditional residential education couldn't reach all people. Distance learning can relieve the situation. However, both private and public providers of higher education (residential and distance can co-exist in South Africa. Private Higher Distance Learning (PHDL contributes in lowering present levels of unemployment by providing skills, as many prospective students stay in rural areas and townships. This paper emphasizes some of the changes impacting on the future of PHDL and bringing education opportunities to masses by creating an environment of shared responsibility between government institutions and private initiatives, jointly servicing a greater part of the population.

  12. Street environment change detection from mobile laser scanning point clouds

    Science.gov (United States)

    Xiao, Wen; Vallet, Bruno; Brédif, Mathieu; Paparoditis, Nicolas

    2015-09-01

    Mobile laser scanning (MLS) has become a popular technique for road inventory, building modelling, infrastructure management, mobility assessment, etc. Meanwhile, due to the high mobility of MLS systems, it is easy to revisit interested areas. However, change detection using MLS data of street environment has seldom been studied. In this paper, an approach that combines occupancy grids and a distance-based method for change detection from MLS point clouds is proposed. Unlike conventional occupancy grids, our occupancy-based method models space based on scanning rays and local point distributions in 3D without voxelization. A local cylindrical reference frame is presented for the interpolation of occupancy between rays according to the scanning geometry. The Dempster-Shafer theory (DST) is utilized for both intra-data evidence fusion and inter-data consistency assessment. Occupancy of reference point cloud is fused at the location of target points and then the consistency is evaluated directly on the points. A point-to-triangle (PTT) distance-based method is combined to improve the occupancy-based method. Because it is robust to penetrable objects, e.g. vegetation, which cause self-conflicts when modelling occupancy. The combined method tackles irregular point density and occlusion problems, also eliminates false detections on penetrable objects.

  13. Physiological changes in women during exercise in cold environments

    Science.gov (United States)

    Murray, S. J.; Shephard, R. J.; Radomski, M. W. M.

    1986-12-01

    Both the stress of exercise and the stress of a cold environment have been shown to increase the mobilization and utilization of body fat, thereby reducing body fat stores. Much of the research has been done on either rats or male human subjects. The purpose of this research was to show the physiological changes which occur to young, relatively obese, women who exercised during five consecutive days, for 200 min per day, in each of three environmental, chamber conditions: (1) warm-warm (WW), +15‡C; (2) cold-cold (CC), -20‡C; and (3) cold-warm (CW), -20‡C ambient temperature, with +18‡C air pumped to face masks for warmed air breathing. Oxygen cost of exercise, respiratory quotients, energy intake and utilization, and body composition changes were measured before, during, and after each environmental condition. While the respiratory quotients and the skinfold measurements decreased in the colder conditions, the underwater weighing determined percentage body fat did not show the same decrement as the skinfold measures, indicating a possible translocation of body fat from the subcutaneous depots to the deep body fat depots. Body mass loss was significant (Pfat in the female, a longer cold exposure would be required to observe the fully developed BAT thermogenesis which would follow after the consequences of fat translocation which we have documented.

  14. Dynamics and life histories of northern ungulates in changing environments

    Science.gov (United States)

    Hendrichsen, D. K.

    2011-12-01

    Regional climate and local weather conditions can profoundly influence life history parameters (growth, survival, fecundity) and population dynamics in northern ungulates (Post and Stenseth 1999, Coulson et al. 2001). The influence is both direct, for example through reduced growth or survival (Aanes et al. 2000, Tyler et al. 2008), and indirect, for example through changes in resource distribution, phenology and quality, changes which subsequently influence consumer dynamics (Post et al. 2008). By comparing and contrasting data from three spatially independent populations of ungulates, I discuss how variation in local weather parameters and vegetation growth influence spatial and temporal dynamics through changes in life history parameters and/or behavioural dynamics. The data originate from long term (11-15 years) monitoring data from three populations of ungulates in one subarctic and two high Arctic sites; semi-domesticated reindeer (Rangifer tarandus tarandus) in northern Norway, Svalbard reindeer (R. t. platyrhynchus) on Spitsbergen and muskoxen (Ovibos moschatus) in Northeast Greenland. The results show that juvenile animals can be particularly vulnerable to changes in their environment, and that this is mirrored to different degrees in the spatio-temporal dynamics of the three populations. Adverse weather conditions, acting either directly or mediated through access to and quality of vegetation, experienced by young early in life, or even by their dams during pregnancy, can lead to reduced growth, lower survival and reduced reproductive performance later in life. The influence of current climatic variation, and the predictions of how local weather conditions may change over time, differs between the three sites, resulting in potentially different responses in the three populations. Aanes R, Saether BE and Øritsland NA. 2000. Fluctuations of an introduced population of Svalbard reindeer: the effects of density dependence and climatic variation. Ecography

  15. Impact of a changing environment on the built heritage

    Science.gov (United States)

    Grossi, C. M.; Brimblecombe, P.; Bonazza, A.

    2012-04-01

    Stone monuments are degraded by both climate and pollution. Deterioration by pollution was especially intense from the 1700s and until the late 20th century the dominant impact of air pollution was the sulfation of surfaces. The parallel deposition of soot caused blackening and on some surfaces dark coloured crusts. The decrease of sulfur and soot from coal combustion during the last decades of the 20th century led to cleaner air in cities, a decrease of pollution-decay rates on building stones and a public desire for cleaner buildings. Although there were decreases in SO2, it was replaced by ozone, nitrogen oxides and particles richer in organic compounds, the result of an extensive use of automobiles. Deposited organic compounds can oxidise in modern urban environments in a yellowing process. The future may reveal variation in building colour from biological growth in a changing climate. In urban atmospheres with less sulfur, biological growth is more effective. A greater rate of delivery of nitrate to building surfaces that acts as "airborne fertiliser" favours colonisation. Depending on climate, there might be different processes (e.g. greening or reddening) and patterns of colouration. Climate is also a relevant factor in the weathering of monuments. Recent research suggests the concept of Heritage Climatology in the study of climate interactions with monuments, materials and sites. These parameters concentrate on aspects and combinations of meteorological variables that relate to material damage. The Köppen-Geiger climate classification can be a good approximation for some heritage risks. For instance, the number of salt transitions shows distinct seasonality which can be related to Köppen-Geiger climate types and their change during the 21th century. The study of changing pollution and climate impacts on the built heritage needs the output of pollution emissions and climate change models, which are prone to uncertainties. The use of multiple climate models

  16. 17 CFR 249.819 - Form 19b-4, for electronic filing with respect to proposed rule changes by all self-regulatory...

    Science.gov (United States)

    2010-04-01

    ... filing with respect to proposed rule changes by all self-regulatory organizations. 249.819 Section 249..., SECURITIES EXCHANGE ACT OF 1934 Forms for Self-Regulatory Organization Rule Changes and Forms for....819 Form 19b-4, for electronic filing with respect to proposed rule changes by all...

  17. Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.

    Directory of Open Access Journals (Sweden)

    Yoichiro Shibata

    2012-06-01

    Full Text Available Understanding the molecular basis for phenotypic differences between humans and other primates remains an outstanding challenge. Mutations in non-coding regulatory DNA that alter gene expression have been hypothesized as a key driver of these phenotypic differences. This has been supported by differential gene expression analyses in general, but not by the identification of specific regulatory elements responsible for changes in transcription and phenotype. To identify the genetic source of regulatory differences, we mapped DNaseI hypersensitive (DHS sites, which mark all types of active gene regulatory elements, genome-wide in the same cell type isolated from human, chimpanzee, and macaque. Most DHS sites were conserved among all three species, as expected based on their central role in regulating transcription. However, we found evidence that several hundred DHS sites were gained or lost on the lineages leading to modern human and chimpanzee. Species-specific DHS site gains are enriched near differentially expressed genes, are positively correlated with increased transcription, show evidence of branch-specific positive selection, and overlap with active chromatin marks. Species-specific sequence differences in transcription factor motifs found within these DHS sites are linked with species-specific changes in chromatin accessibility. Together, these indicate that the regulatory elements identified here are genetic contributors to transcriptional and phenotypic differences among primate species.

  18. Regulation of Nuclear Security in the Russian Federation: Changes and Amendments to the Regulatory Framework Since 2009

    International Nuclear Information System (INIS)

    This presentation covers the measures related to regulation of nuclear security in the Russian Federation taken during the period since 2009 and activities planned for the future. Changes and amendments to the regulatory and methodological documents of federal and departmental levels are described. (author)

  19. 75 FR 22668 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2010-04-29

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To Amend BATS Rules 2.5 and 17.2 Applicable to Registration Requirements April 22, 2010. Pursuant to...\\ notice is hereby given that on April 9, 2010, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  20. 76 FR 59472 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2011-09-26

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To Amend and Restate the Amended and Restated Bylaws of BATS Global Markets, Inc. September 19, 2011... thereunder,\\2\\ notice is hereby given that on September 7, 2011, BATS Exchange, Inc. (the ``Exchange''...

  1. 76 FR 59462 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2011-09-26

    ... COMMISSION Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change To Amend and Restate the Amended and Restated Bylaws of BATS Global Markets, Inc. September 19, 2011... thereunder,\\2\\ notice is hereby given that on September 7, 2011, BATS Y-Exchange, Inc. (the ``Exchange''...

  2. 75 FR 28834 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2010-05-24

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To Amend BATS Rule 11.18, Entitled ``Trading Halts Due to Extraordinary Market Volatility'' May 19, 2010... thereunder,\\2\\ notice is hereby given that on May 18, 2010, BATS Exchange, Inc. (the ``Exchange'' or...

  3. 77 FR 15152 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change by...

    Science.gov (United States)

    2012-03-14

    ...). \\3\\ See Securities Exchange Act Release No. 58375 (August 21, 2008), 73 FR 49498 (August 21, 2008...). \\4\\ See Securities Exchange Act Release No. 62716 (August 13, 2010), 75 FR 51295 (August 19, 2010... COMMISSION Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change...

  4. 77 FR 67851 - Self-Regulatory Organizations; BOX Options Exchange LLC; Order Approving Proposed Rule Change To...

    Science.gov (United States)

    2012-11-14

    ... COMMISSION Self-Regulatory Organizations; BOX Options Exchange LLC; Order Approving Proposed Rule Change To.... 67592 (August 3, 2012), 77 FR 47681 (``Notice''). \\5\\ See Letter to Elizabeth M. Murphy, Secretary... basis. See Securities Exchange Act Release Nos. 49068 (January 13, 2004), 69 FR 2775 (January 20,...

  5. 75 FR 31488 - Self-Regulatory Organizations; New York Stock Exchange, LLC; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2010-06-03

    ... COMMISSION Self-Regulatory Organizations; New York Stock Exchange, LLC; Order Approving Proposed Rule Change...\\ 17 CFR 240.19b-4. \\3\\ See Securities Exchange Act Release No. 61914 (April 15, 2010), 75 FR 21077. II.... See Securities Exchange Act Release No. 59606 (March 19, 2009), 74 FR 13293 (March 26, 2009)...

  6. 75 FR 30078 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NASDAQ OMX PHLX, Inc...

    Science.gov (United States)

    2010-05-28

    .... I. Self-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change... Release Nos. 48013 (June 11, 2003), 68 FR 35933 (June 17, 2003) (SR-Phlx-2002-55) (approval of pilot program); 49801 (June 3, 2004), 69 FR 32652 (June 10, 2004) (SR-Phlx-2004-38); 51768 (May 31, 2005), 70...

  7. 75 FR 69491 - Self-Regulatory Organizations; Order Approving Proposed Rule Change by New York Stock Exchange...

    Science.gov (United States)

    2010-11-12

    ...). \\2\\ 17 CFR 240.19b-4. \\3\\ See Securities Exchange Act Release No. 62955 (September 20, 2010), 75 FR... operation of the NYBX. \\4\\ See Securities Exchange Act Release No. 59282 (January 22, 2009), 74 FR 5009... COMMISSION Self-Regulatory Organizations; Order Approving Proposed Rule Change by New York Stock Exchange...

  8. 75 FR 76059 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of a Proposed Rule Change To...

    Science.gov (United States)

    2010-12-07

    ...-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change The Exchange is... Act Release No. 51759 (May 27, 2005), 70 FR 32860 (June 6, 2005) (SR-Phlx-2004-91) (order approving..., 2005), 70 FR 72193 (December 1, 2005) (SR-PCX-2005-56) (order approving certain modifications to...

  9. 78 FR 68116 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2013-11-13

    ...-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In...\\ Securities Exchange Act Release No. 67347 (July 3, 2012, 77 FR 40673 (July 10, 2012) (SR-NYSE-2011-55; SR... Structure, Securities Exchange Act Release No. 61358 (January 14, 2010), 75 FR 3594 (January 21,...

  10. 78 FR 10233 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Science.gov (United States)

    2013-02-13

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating to the Listing and Trading of the SPDR Blackstone/GSO Senior Loan ETF Under NYSE Arca Equities Rule 8.600 February 7, 2013. Pursuant to...

  11. 78 FR 19766 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change...

    Science.gov (United States)

    2013-04-02

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change Relating to the Listing and Trading of the SPDR Blackstone/GSO Senior Loan ETF Under NYSE Arca Equities Rule 8.600 March 27, 2013. I....

  12. Changes in cis-regulatory elements of a key floral regulator are associated with divergence of inflorescence architectures.

    Science.gov (United States)

    Kusters, Elske; Della Pina, Serena; Castel, Rob; Souer, Erik; Koes, Ronald

    2015-08-15

    Higher plant species diverged extensively with regard to the moment (flowering time) and position (inflorescence architecture) at which flowers are formed. This seems largely caused by variation in the expression patterns of conserved genes that specify floral meristem identity (FMI), rather than changes in the encoded proteins. Here, we report a functional comparison of the promoters of homologous FMI genes from Arabidopsis, petunia, tomato and Antirrhinum. Analysis of promoter-reporter constructs in petunia and Arabidopsis, as well as complementation experiments, showed that the divergent expression of leafy (LFY) and the petunia homolog aberrant leaf and flower (ALF) results from alterations in the upstream regulatory network rather than cis-regulatory changes. The divergent expression of unusual floral organs (UFO) from Arabidopsis, and the petunia homolog double top (DOT), however, is caused by the loss or gain of cis-regulatory promoter elements, which respond to trans-acting factors that are expressed in similar patterns in both species. Introduction of pUFO:UFO causes no obvious defects in Arabidopsis, but in petunia it causes the precocious and ectopic formation of flowers. This provides an example of how a change in a cis-regulatory region can account for a change in the plant body plan. PMID:26220938

  13. 75 FR 36136 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Approving Proposed Rule Change To Amend...

    Science.gov (United States)

    2010-06-24

    ... Exchange's Bylaws to eliminate the Exchange's Audit Committee, Compensation Committee, and Regulatory.... 62032 (May 4, 2010), 75 FR 26304 (``Notice''). I. Description of the Proposed Rule Change Currently, the... Audit Committee and Compensation Committee. As more fully discussed in the Notice, the Exchange...

  14. Changing environments: Coping with diversity and globalization [Session summary

    International Nuclear Information System (INIS)

    Full text: This session explored issues and challenges arising from the globalization of the nuclear industry. There was recognition that the industry has moved towards a smaller number of vendors and nuclear safety standards needed to evolve towards more harmonized international requirements. Also, in the future, nuclear regulatory systems need to approach common, harmonized approaches to deliver consistent nuclear safety regulations. There was also recognition that to support new nuclear design concepts, and new regulatory approaches, new research and development is needed. There was also a need for R and D to be widely shared. New approaches based upon international design certification processes were proposed as a way of providing effective and efficient harmonization of regulatory standards for new reactor systems. The key issues to emerge were: (1) Globalization calls for more harmonization of regulatory requirements, where appropriate. Efforts in this direction are pursued at the regional levels, acknowledging that harmonization does not mean uniformity. The role of the IAEA safety standards in building an international nuclear safety regime has also increased. (2) The regulatory community will benefit strongly from cross-fertilization between regional and multinational efforts, and the international developments of more user friendly safety standards that take into account the feedback from different users. Consideration should also be given to mapping the coverage and identifying differences and gaps between IAEA and industrial safety standards. (3) There is a need to build on the IAEA safety standards to provide vendors, operators and regulators with international standards for design and operation of nuclear installations: - There is a need to develop a process whereby regulatory bodies can get together to assess and agree on a design so that the design can be accepted in any country; - There was disagreement as to whether design certification was an

  15. The Worldviews Network: Transformative Global Change Education in Immersive Environments

    Science.gov (United States)

    Hamilton, H.; Yu, K. C.; Gardiner, N.; McConville, D.; Connolly, R.; "Irving, Lindsay", L. S.

    2011-12-01

    Our modern age is defined by an astounding capacity to generate scientific information. From DNA to dark matter, human ingenuity and technologies create an endless stream of data about ourselves and the world of which we are a part. Yet we largely founder in transforming information into understanding, and understanding into rational action for our society as a whole. Earth and biodiversity scientists are especially frustrated by this impasse because the data they gather often point to a clash between Earth's capacity to sustain life and the decisions that humans make to garner the planet's resources. Immersive virtual environments offer an underexplored link in the translation of scientific data into public understanding, dialogue, and action. The Worldviews Network is a collaboration of scientists, artists, and educators focused on developing best practices for the use of immersive environments for science-based ecological literacy education. A central tenet of the Worldviews Network is that there are multiple ways to know and experience the world, so we are developing scientifically accurate, geographically relevant, and culturally appropriate programming to promote ecological literacy within informal science education programs across the United States. The goal of Worldviews Network is to offer transformative learning experiences, in which participants are guided on a process integrating immersive visual explorations, critical reflection and dialogue, and design-oriented approaches to action - or more simply, seeing, knowing, and doing. Our methods center on live presentations, interactive scientific visualizations, and sustainability dialogues hosted at informal science institutions. Our approach uses datasets from the life, Earth, and space sciences to illuminate the complex conditions that support life on earth and the ways in which ecological systems interact. We are leveraging scientific data from federal agencies, non-governmental organizations, and our

  16. The Change of Financial Environment and the Evolvement of Financial Goals

    OpenAIRE

    Jianhui Jian

    2009-01-01

    With the changing financial environment, financial goals are constantly changing. In the course of development of financial theory, there were numerous financial goals theories, which are mainly "profit maximization, shareholders’ wealth maximization, and stakeholders’ wealth maximization." These financial goals basically reflect the business requirements of the market environment, the adaptation to the changing financial environment, and also reflect the different preferences of the differen...

  17. Foreign capital, forest change and regulatory compliance in Congo Basin forests

    International Nuclear Information System (INIS)

    Tropical forest change is driven by demand in distant markets. Equally, investments in tropical forest landscapes by capital originating from distant emerging economies are on the rise. Understanding how forest outcomes vary by investment source is therefore becoming increasingly important. We empirically evaluate the relationship between investment source and deforestation from 2000 to 2010 in the Republic of Congo. A Congolese forestry code was implemented in 2000 to mitigate degradation of production forests by standardizing all logging in the country according to sustainable forest management (SFM) guidelines. Following the implementation of this law, the majority (73%) of Congo’s production forests were managed by European (40%) and Asian (33%) companies. European concessions had the highest rates of total and core deforestation, followed by Asian concessions, indicating that the fragmentation of intact forests in Congo is strongly associated with industrial logging fueled by foreign capital. European concession holders were also far more likely to comply with SFM policies, followed by Asian concessions, suggesting that compliance with Sustainable Forest Management policies may not mitigate degradation in tropical production forests. Further evaluation of the relationship between investment source, regulatory compliance, and outcomes in tropical countries is essential for effective conservation of tropical forest ecosystems. (paper)

  18. Photoprotection in changing times - UV filter efficacy and safety, sensitization processes and regulatory aspects.

    Science.gov (United States)

    Stiefel, C; Schwack, W

    2015-02-01

    As excessive sun exposure is tightly associated with different pathological changes of the skin, for example premature skin ageing or the development of skin cancer, an appropriate protection of the skin against UV radiation is of particular importance. Sun protection products and UV filter substances have evolved continuously in the past few decades. New developments and improved technical conditions of production have led to increasingly effective and efficient products with broadband protection ability. Accordingly, legal requirements have also changed and expanded. Although certain trends exist to harmonize the regulation of sunscreens at a global level, there are still large differences how UV absorbers are approved, which testing methods are prescribed, and which general requirements sun protection products must fulfil. Modern UV filters provide efficient protection against UVA and UVB radiation, are heat and photostable, user-friendly, cost-effective, water resistant and non-toxic. As inorganic and organic UV filters are topically applied to the skin in relatively high concentrations (up to 25%), especially the assessment of their (photo)sensitization potential is of particular importance. Accordingly, skin sensitization is a key endpoint for the legally required safety assessment of cosmetic ingredients in Europe and many other countries. This review will summarize the current regulatory status of different approved UV filters, will describe their beneficial and adverse properties and will give an overview of how the efficacy of sunscreens can be evaluated. Finally, an insight into the basic mechanism of (photo)allergic reactions and existing skin sensitization test methods will be provided. PMID:25256657

  19. NTL 11 spent fuel flask - meeting the challenge of regulatory and technological change

    International Nuclear Information System (INIS)

    By June 2005, when shipments of spent fuel for reprocessing from Germany are concluded, the NTL11 flask type will have been responsible for transporting a total of 1500 tonnes of heavy metal in the form of spent fuel. Excluding domestic transports in France and the UK, this represents 25% of the total European spent fuel transported for reprocessing since the flasks came into service in 1977. Approximately 40% of the total for the flask type will have been transported to BNFL's Sellafield facility, the remainder to Cogema at La Hague. The NTL11 flask can justifiably be described as being the workhorse of BNFL's European spent fuel transport business. The NTL11 flask started life under the ownership of Nuclear Transport Limited, an associate company of BNFL, and in recent years the original fleet of five flasks has been absorbed into the BNFL inventory. A recent build programme has seen a further four flasks added to the fleet, an expedient measure to cope with the additional transport requirements imposed by the need to meet the June 2005 deadline for the removal of contracted fuels from Germany. While there have been certain evolutionary changes affecting the package design, there have also been more significant changes in the Design Safety Case. These have sometimes been necessary to meet regulatory changes, or the challenges posed by the regulators. In other cases advantage has been taken of improvements in analytical techniques to demonstrate increased margins of operational safety. Where possible those margins have also been increased by other means, such as taking advantage of commercial trends to reduce package thermal loads. The NTL11 flask was designed around the reactor and fuel characteristics prevailing in the 1970's. Over the lifetime of the flask the responsible engineering teams have faced and met the successive challenges to develop the capability of the Package to face the changing requirements of the industry and the Transport Regulations. Both

  20. Changes in FDA enforcement activities following changes in federal administration: the case of regulatory letters released to pharmaceutical companies

    OpenAIRE

    Nguyen Diane; Seoane-Vazquez Enrique; Rodriguez-Monguio Rosa; Montagne Michael

    2013-01-01

    Abstract Background The United States (US) Food and Drug Administration (FDA) is responsible for the protection of the public health by assuring the safety, effectiveness and security of human drugs and biological products through the enforcement of the Federal Food, Drug and Cosmetic Act (FDCA) and related regulations. These enforcement activities include regulatory letters (i.e. warning letters and notice of violation) to pharmaceutical companies. A regulatory letter represents the FDA’s fi...

  1. Verification ghosts. The changing political environment of the IAEA

    International Nuclear Information System (INIS)

    Six years ago, Dr. Hans Blix wrote in the IAEA Bulletin of a 'general optimism about further arms control and verification.' At the time, world events warranted such a prognosis; the IAEA was riding a wave of momentum after its instrumental role in the roll-back of the South African nuclear weapons program and bringing Ukraine, Belarus, and Kazakhstan into the Nuclear Non Proliferation Treaty (NPT) as non-nuclear-weapon States. The NPT's indefinite extension was only two years old, and the most pressing challenges, while recognizable, were somewhat stagnant. Today, some tidings elicit similar optimism. The IAEA's increasing efforts to combat terrorism and the decision by Member States to depart from nearly 20 years of zero real growth budgetary policy are remarkable testaments to the Agency's adaptability and credibility in the face of new threats. And with the worldwide frenzy over terrorism and redoubled phobia of weapons of mass destruction (WMD), the Agency garners public attention now as never before. Emblematic of this recent upsurge in political attention, US President George W. Bush's annual State of the Union address in 2003 mentioned supporting the IAEA as a specific priority of his administration, the first mention of the Agency in that speech since President Eisenhower in 1961 lauded its creation under 'Atoms for Peace'. Such visibility portends a future with prospects for overcoming bureaucratic inertia and effecting significant changes to the Agency's benefit. But with that visibility has come an uncertainty about the IAEA's role in world affairs. Despite being able to resolve most benign problems more easily, the Agency must operate in an environment haunted by the non-proliferation analogue of Charles Dickens' triumvirate specters: the ghosts of verification challenges past, present and future -namely, the cessation of UN-mandated inspections in Iraq, the difficulties ensuring compliance in North Korea and Iran, and the need to maintain the IAEA

  2. ACCOUNTING AND FINANCIAL REPORTING IN A CHANGING ENVIRONMENT: HISTORICAL AND THEORETICAL PERSPECTIVES

    OpenAIRE

    Stanley Salvary

    2005-01-01

    Over time, a changing environment has produced changes in the types of accounting information and in the dissemination of such information (financial reporting). Certain changes in the environment do impel changes in accounting. This paper examines various theoretical issues in accounting in a historical setting and provides some insight on the manner in which the accounting profession has responded to problems.

  3. A REVIEW OF CHANGES IN RUSSIA’S REGULATORY FRAMEWORK IN AUGUST 2014

    OpenAIRE

    Irina Tolmacheva; Yulia Grunina

    2014-01-01

    The following key amendments to the Russian regulatory framework were made in August 2014. Owners of living quarters will be legally bound to noti fy the Federal Migrati on Service of Russia of other individuals residing in the living quarters in legally established cases; under the Federal Law Concerning Special Evaluation of Working Conditions, the Government of Russia will streamline its regulatory framework; educational institutions will submit their students to social-physiological testi...

  4. Negotiating structural vulnerability following regulatory changes to a provincial methadone program in Vancouver, Canada: A qualitative study.

    Science.gov (United States)

    McNeil, Ryan; Kerr, Thomas; Anderson, Solanna; Maher, Lisa; Keewatin, Chereece; Milloy, M J; Wood, Evan; Small, Will

    2015-05-01

    While regulatory frameworks governing methadone maintenance therapy (MMT) require highly regimented treatment programs that shape treatment outcomes, little research has examined the effects of regulatory changes to these programs on those receiving treatment, and located their experiences within the wider context of social-structural inequities. In British Columbia (BC), Canada, provincial regulations governing MMT have recently been modified, including: replacing the existing methadone formulation with Methadose(®) (pre-mixed and 10 times more concentrated); prohibiting pharmacy delivery of methadone; and, prohibiting pharmacies incentives for methadone dispensation. We undertook this study to examine the impacts of these changes on a structurally vulnerable population enrolled in MMT in Vancouver, BC. Qualitative interviews were conducted with 34 people enrolled in MMT and recruited from two ongoing observational prospective cohort studies comprised of drug-using individuals in the six-month period in 2014 following these regulatory changes. Interview transcripts were analysed thematically, and by drawing on the concept of 'structural vulnerability'. Findings underscore how these regulatory changes disrupted treatment engagement, producing considerable health and social harms. The introduction of Methadose(®) precipitated increased withdrawal symptoms. The discontinuation of pharmacy delivery services led to interruptions in MMT and co-dispensed HIV medications due to constraints stemming from their structural vulnerability (e.g., poverty, homelessness). Meanwhile, the loss of pharmacy incentives limited access to material supports utilized by participants to overcome barriers to MMT, while diminishing their capacity to assert some degree of agency in negotiating dispensation arrangements with pharmacies. Collectively, these changes functioned to compromise MMT engagement and increased structural vulnerability to harm, including re-initiation of injection drug

  5. 17 CFR 249.822 - Form 19b-7, for electronic filing with respect to proposed rule changes by self-regulatory...

    Science.gov (United States)

    2010-04-01

    ... filing with respect to proposed rule changes by self-regulatory organizations under Section 19(b)(7)(A... SECURITIES AND EXCHANGE COMMISSION (CONTINUED) FORMS, SECURITIES EXCHANGE ACT OF 1934 Forms for Self... proposed rule changes by self-regulatory organizations under Section 19(b)(7)(A) of the Securities...

  6. A look at the changing environment along the Indian coasts

    Digital Repository Service at National Institute of Oceanography (India)

    Desai, B.N.; Das, V

    stream_size 6 stream_content_type text/plain stream_name Natl_Symp_Environ_1992_V.pdf.txt stream_source_info Natl_Symp_Environ_1992_V.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  7. Strategic Renewal in Regulatory Environments. How inter- and intra-organisational institutional forces influence European incumbent energy firms

    Energy Technology Data Exchange (ETDEWEB)

    Stienstra, M.

    2008-11-20

    How do incumbent firms strategically renew in regulatory environments? Assuming that regulation can both constrain and enable a firm's strategic renewal opportunities, we investigate how and to what extent incumbent firms undertake exploitative and explorative strategic renewal actions in order to remain competitive. Exploitative strategic renewal involves those actions that strengthen or optimise a firm's current resource deployments, whereas explorative strategic renewal relates to actions that generate new sources of value creation for the firm. Based on old institutional theory, new institutional theory, neo-institutional theory and institutional entrepreneurship literature, a multi-level framework that combines selection and adaptation arguments has been developed and applied to investigate strategic renewal behaviour of a sample of European energy incumbents. At industry level of analysis, results show how inter-organisational institutional forces significantly impact firms' choices of exploitative and explorative strategic renewal actions through regulative, normative and cognitive forces. At organisational unit level of analysis, we find that the extent of intra-organisational regulative forces is positively related to exploitative strategic renewal actions. In addition, entrepreneurial proclivity appears to be a catalyst of both exploitative and explorative strategic renewal actions. Finally, our results provide insights how environmental selection and firm level adaptation are interrelated in the context of regulation. The extent of inter-organisational regulative forces positively moderates the relationship between intra-organisational regulative forces and exploitative strategic renewal actions.

  8. CAFE: A Computer Tool for Accurate Simulation of the Regulatory Pool Fire Environment for Type B Packages

    International Nuclear Information System (INIS)

    The Container Analysis Fire Environment computer code (CAFE) is intended to provide Type B package designers with an enhanced engulfing fire boundary condition when combined with the PATRAN/P-Thermal commercial code. Historically an engulfing fire boundary condition has been modeled as σT4 where σ is the Stefan-Boltzman constant, and T is the fire temperature. The CAFE code includes the necessary chemistry, thermal radiation, and fluid mechanics to model an engulfing fire. Effects included are the local cooling of gases that form a protective boundary layer that reduces the incoming radiant heat flux to values lower than expected from a simple σT4 model. In addition, the effect of object shape on mixing that may increase the local fire temperature is included. Both high and low temperature regions that depend upon the local availability of oxygen are also calculated. Thus the competing effects that can both increase and decrease the local values of radiant heat flux are included in a reamer that is not predictable a-priori. The CAFE package consists of a group of computer subroutines that can be linked to workstation-based thermal analysis codes in order to predict package performance during regulatory and other accident fire scenarios

  9. Strategic Renewal in Regulatory Environments. How inter- and intra-organisational institutional forces influence European incumbent energy firms

    International Nuclear Information System (INIS)

    How do incumbent firms strategically renew in regulatory environments? Assuming that regulation can both constrain and enable a firm's strategic renewal opportunities, we investigate how and to what extent incumbent firms undertake exploitative and explorative strategic renewal actions in order to remain competitive. Exploitative strategic renewal involves those actions that strengthen or optimise a firm's current resource deployments, whereas explorative strategic renewal relates to actions that generate new sources of value creation for the firm. Based on old institutional theory, new institutional theory, neo-institutional theory and institutional entrepreneurship literature, a multi-level framework that combines selection and adaptation arguments has been developed and applied to investigate strategic renewal behaviour of a sample of European energy incumbents. At industry level of analysis, results show how inter-organisational institutional forces significantly impact firms' choices of exploitative and explorative strategic renewal actions through regulative, normative and cognitive forces. At organisational unit level of analysis, we find that the extent of intra-organisational regulative forces is positively related to exploitative strategic renewal actions. In addition, entrepreneurial proclivity appears to be a catalyst of both exploitative and explorative strategic renewal actions. Finally, our results provide insights how environmental selection and firm level adaptation are interrelated in the context of regulation. The extent of inter-organisational regulative forces positively moderates the relationship between intra-organisational regulative forces and exploitative strategic renewal actions.

  10. Ecotones in a changing environment: Workshop on ecotones and global change

    Energy Technology Data Exchange (ETDEWEB)

    Risser, P.G.

    1990-02-01

    The Scientific Committee on Problems of the Environment (SCOPE) has organized an international project to synthesize and advance current theory on the influence of ecotones, or transition zones between ecosystems, on biodiversity and flows of energy, nutrients, water, and project is other materials between ecosystems. In particular, the entire project is designed to evaluate the influence of global climate change and land-use practices on biodiversity and ecological flows associated with ecotones, and will assess the feasibility of monitoring ecotones as early indicators of global change. The later stages of the project will recommend landscape management strategies for ecotones that produce desirable patterns of biodiversity and ecological flows. The result of the project--a comprehensive body of information on the theory and management of biodiversity and ecological flows associated with ecotones--will be part of the planning for research to be carried out under the International Geosphere-Biosphere Program.

  11. Changes in peripheral blood level of regulatory T cells in patients with malignant melanoma during treatment with dendritic cell vaccination and low-dose IL-2

    DEFF Research Database (Denmark)

    Bjoern, J; Brimnes, M K; Andersen, M H;

    2011-01-01

    In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-a and IL-2. The regulatory subset of CD4 T cells, characterized by CD25(high) , was prospecti......In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-a and IL-2. The regulatory subset of CD4 T cells, characterized by CD25(high) , was...

  12. Changes in peripheral blood level of regulatory T cells in patients with malignant melanoma during treatment with dendritic cell vaccination and low-dose IL-2

    DEFF Research Database (Denmark)

    Bjoern, J; Brimnes, M K; Andersen, M H;

    2011-01-01

    In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-α and IL-2. The regulatory subset of CD4 T cells, characterized by CD25(high) , was prospecti......In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-α and IL-2. The regulatory subset of CD4 T cells, characterized by CD25(high) , was...

  13. The impact of business environment changes on recent costing techniques

    Institute of Scientific and Technical Information of China (English)

    林慧涓

    2011-01-01

    1.Introduction The acceleration of globalization and the prosperity of information technology benefit business a great deal.But with the speeding up of economic development,firms are facing more and more pressure from various aspects of their business.The heated debate is on about whether traditional management accounting practices and techniques are irrelevant to the current business environment and this essay will explore the causes for using some traditional management accounting practices and techniques in the current business environment are inappropriate and put forward some contemporary management accounting techniques which is relevant to the current business environment.Thus,the essay will be divided into three sections to discuss the traditional management accounting practices and techniques and contemporary management accounting techniques in current business environment.

  14. Changes in the perceived neighborhood environment in relation to changes in physical activity: A longitudinal study from childhood into adolescence.

    Science.gov (United States)

    D'Haese, Sara; De Meester, Femke; Cardon, Greet; De Bourdeaudhuij, Ilse; Deforche, Benedicte; Van Dyck, Delfien

    2015-05-01

    The aim was to investigate how physical activity and the perceived neighborhood environment in children change when they enter adolescence. Also the relation between changes in the perceived environment and changes in children's physical activity was investigated. In total, 321 children and one of their parents filled out a physical activity questionnaire and the NEWS-Y at two time points (last grade of elementary school and 2 years later). Children also wore an activity monitor. Changes in children's physical activity were dependent on the physical activity domain. Only less than half of children's perceived neighborhood factors changed and about half of the parental perceived neighborhood factors changed. Most of these factors changed towards higher activity friendliness. Changes in the perceived environment were only limitedly related to changes in children's physical activity. PMID:25840351

  15. Designing for change: mash-up personal learning environments

    OpenAIRE

    Wild, Fridolin; Mödritscher, Felix; Sigurdarson, Steinn

    2008-01-01

    Institutions for formal education and most work places are equipped today with at least some kind of tools that bring together people and content artefacts in learning activities to support them in constructing and processing information and knowledge. For almost half a century, science and practice have been discussing models on how to bring personalisation through digital means to these environments. Learning environments and their construction as well as maintenance makes up the most cruci...

  16. Utilization of Unmanned Aerial Vehicles for Rangeland Resources Monitoring in a Changing Regulatory Environment (Invited)

    Science.gov (United States)

    Rango, A.; Vivoni, E. R.; Browning, D. M.; Anderson, C.; Laliberte, A. S.

    2013-12-01

    It is taking longer than expected to realize the immense potential of Unmanned Aerial Vehicles (UAVs)for civil applications due to the complexity of regulations being developed by the Federal Aviation Authority (FAA) that can be applied to both manned and unmanned flight in the National Airspace System (NAS). As a result, FAA has required that for all UAV flights in the NAS, an external pilot must maintain line-of-sight contact with the UAV. Properly trained observers must also be present to assist the external pilot in collision avoidance. Additionally, in order to fly in the NAS, formal approval must be requested from FAA through application for a Certificate of Authorization (COA for government applicants or a Special Airworthiness Certificate (SAC) in the experimental category for non-government applicants. Flight crews of UAVs must pass exams also required for manned airplane pilots. Although flight crews for UAVs are not required to become manned airplane pilots, UAV flight missions are much more efficient if one or two of the UAV flight crew are also manned aircraft pilots so they can serve as the UAV mission commander. Our group has performed numerous UAV flights within the Jornada Experimental Range in southern New Mexico. Two developments with Jornada UAVs can be recommended to other UAV operators that would increase flight time experience and study areas covered by UAV images. First, do not overlook the possibility of obtaining permission to fly in Restricted Military Airspace (RMA). At the Jornada, our airspace is approximately 50% NAS and 50% RMA. With experiments ongoing in both types of airspace, we can fly in both areas and continue to increase UAV flights. Second, we have developed an air- and-ground vehicle approach for long distance, continuous pilot transport that always maintains line-of-sight requirements. This allows flying several target areas on a single mission and increasing the number of acquired UAV images - over 90,000 UAV images have now been acquired at Jornada. Most of our UAV flights have taken place over rangelands or watersheds in the western U.S. These flights have been successful used for classification of vegetation cover and type, measuring gaps between vegetation patches, identifing locations of potentially erosive soil, deriving digital elevation models, and monitoring plant phenology.. These measurements can be directly compared to more costly and time-intensive traditional techniques used in rangeland health determinations. New UAVs are becoming available with increased sensor payload capacity. At Jornada we have concentrated on flying at low altitudes (~215 m) to acquire hyperspatial resolutions with digital cameras of about 5-6 cm. We also fly a six band multispectral camera with spatial resolution of ~ 13 cm. We have recently acquired a larger Bat-4 UAV to go with the Bat-3 UAV. The major improvement associated with this upgrade is an increase in sensor payload from 1.4 kg to 14 kg. We are surveying the type of sensors that we could add to best increase our information content.

  17. Approaches to Electric Utility Energy Efficiency for Low Income Customers in a Changing Regulatory Environment

    Energy Technology Data Exchange (ETDEWEB)

    Brockway, N.

    2001-05-21

    As the electric industry goes through a transformation to a more market-driven model, traditional grounds for utility energy efficiency have come under fire, undermining the existing mechanisms to fund and deliver such services. The challenge, then, is to understand why the electric industry should sustain investments in helping low-income Americans use electricity efficiently, how such investments should be made, and how these policies can become part of the new electric industry structure. This report analyzes the opportunities and barriers to leveraging electric utility energy efficiency assistance to low-income customers during the transition of the electric industry to greater competition.

  18. Approaches to Electric Utility Energy Efficiency for Low Income Customers in a Changing Regulatory Environment; TOPICAL

    International Nuclear Information System (INIS)

    As the electric industry goes through a transformation to a more market-driven model, traditional grounds for utility energy efficiency have come under fire, undermining the existing mechanisms to fund and deliver such services. The challenge, then, is to understand why the electric industry should sustain investments in helping low-income Americans use electricity efficiently, how such investments should be made, and how these policies can become part of the new electric industry structure. This report analyzes the opportunities and barriers to leveraging electric utility energy efficiency assistance to lo-w-income customers during the transition of the electric industry to greater competition

  19. Emerging Vector-borne Diseases in a Changing Environment

    OpenAIRE

    ÖZER, Nurdan

    2005-01-01

    Vector-borne infectious diseases are emerging or resurging as a result of changes in public health policy, demographic and societal changes, insecticide and drug resistance, shift in emphasis from prevention to emergency response, genetic changes in pathogens in the last two decades of the twentieth century. Climate changes also can influence the emergence and reemergence of these diseases which are malaria, dengue, yellow fever, plague, filariasis, louse-borne typhus, lyme disease, trypanoso...

  20. Fostering Entrepreneurial Investment Decision in Medical Technology Ventures in a Changing Business Environment

    Directory of Open Access Journals (Sweden)

    Sonja Bettina Keppler

    2015-02-01

    Full Text Available This paper presents the results obtained from a survey among public and private venture capitalists from countries which attract a large amount of venture capital investment: Germany, Switzerland, Austria and Israel. The objective is to investigate venture capitalists’ investment criteria for medical technology ventures in the start-up or expansion phase. Since existing research evaluated venture capitalists’ general investment criteria, the aim of this study is to provide specific results on entrepreneurial investment decisions for the medical technology sector, which constantly attracted a significant share of European venture capital. The research used semi-structured interviews with 39 venture capitalists and experts. The results show that venture capitalists prefer to invest in companies which develop products for treating and diagnosing diseases showing a high prevalence and large market volumes, such as cardiovascular, metabolic and neurological diseases, and orthopaedic disorders. The study confirms that venture capitalists use a number of industry-specific criteria highly relevant in a changing business environment. These include a high medical need for the product, availability of clinical data, stage of European Conformity approval, high probability of receiving reimbursement from health insurances, medical key opinion leaders supporting technology, management’s regulatory experience and their communication ability with doctors and key opinion leaders.

  1. Changing Public Discourse on the Environment: Danish Media Coverage of the Rio and Johannesburg UN Summits

    DEFF Research Database (Denmark)

    Petersen, Lars Kjerulf

    2008-01-01

    cases of wider public conceptions of the environment. Over a decade rhetoric about the summits and the environment changed, the agenda changed, and key environmental issues were repackaged. These changes are further interpreted in relation to ecological modernisation and discussed as a possible...

  2. Department of Energy LLW disposal; adapting to a changing environment

    International Nuclear Information System (INIS)

    The Department of Energy's philosophy is evolving to meet the challenge of providing safe and cost-effective LLW management. The DOE expects to use a system approach by obtaining consensus on performance requirements with all of the involved regulatory agencies and by applying these performance requirements to the best available site. Engineered features will be added either through the stabilization of the waste or site improvements as required to meet the performance requirements. Necessary waste stabilization will be incorporated into the waste acceptance criteria relieving the operator from making waste treatment decisions on a strict cost-effectiveness basis. The initial analysis to determine a configuration which meets minimum performance requirements will also serve as the baseline for additional analyses to meet the ALARA requirements

  3. 78 FR 29186 - Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2013-05-17

    ...\\ Release No. 34-69276 (Apr. 2, 2013), 78 FR 20999 (Apr. 8, 2013). II. Description DTC filed the Proposed...)(3)(F). \\12\\ Release No. 34-68080 (Oct. 22, 2012), 77 FR 66219 (Nov. 2, 2012). \\13\\ 17 CFR 240.17Ad... COMMISSION Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule...

  4. A recurrent regulatory change underlying altered expression and Wnt response of the stickleback armor plates gene EDA.

    Science.gov (United States)

    O'Brown, Natasha M; Summers, Brian R; Jones, Felicity C; Brady, Shannon D; Kingsley, David M

    2015-01-01

    Armor plate changes in sticklebacks are a classic example of repeated adaptive evolution. Previous studies identified ectodysplasin (EDA) gene as the major locus controlling recurrent plate loss in freshwater fish, though the causative DNA alterations were not known. Here we show that freshwater EDA alleles have cis-acting regulatory changes that reduce expression in developing plates and spines. An identical T → G base pair change is found in EDA enhancers of divergent low-plated fish. Recreation of the T → G change in a marine enhancer strongly reduces expression in posterior armor plates. Bead implantation and cell culture experiments show that Wnt signaling strongly activates the marine EDA enhancer, and the freshwater T → G change reduces Wnt responsiveness. Thus parallel evolution of low-plated sticklebacks has occurred through a shared DNA regulatory change, which reduces the sensitivity of an EDA enhancer to Wnt signaling, and alters expression in developing armor plates while preserving expression in other tissues. PMID:25629660

  5. Comparative Risk Assessment to Inform Adaptation Priorities for the Natural Environment: Observations from the First UK Climate Change Risk Assessment

    Directory of Open Access Journals (Sweden)

    Iain Brown

    2015-11-01

    Full Text Available Risk assessment can potentially provide an objective framework to synthesise and prioritise climate change risks to inform adaptation policy. However, there are significant challenges in the application of comparative risk assessment procedures to climate change, particularly for the natural environment. These challenges are evaluated with particular reference to the first statutory Climate Change Risk Assessment (CCRA and evidence review procedures used to guide policy for the UK government. More progress was achieved on risk identification, screening and prioritisation compared to risk quantification. This was due to the inherent complexity and interdependence of ecological risks and their interaction with socio-economic drivers as well as a climate change. Robust strategies to manage risk were identified as those that coordinate organisational resources to enhance ecosystem resilience, and to accommodate inevitable change, rather than to meet specific species or habitats targets. The assessment also highlighted subjective and contextual components of risk appraisal including ethical issues regarding the level of human intervention in the natural environment and the proposed outcomes of any intervention. This suggests that goals for risk assessment need to be more clearly explicated and assumptions on tolerable risk declared as a primer for further dialogue on expectations for managed outcomes. Ecosystem-based adaptation may mean that traditional habitats and species conservation goals and existing regulatory frameworks no longer provide the best guide for long-term risk management thereby challenging the viability of some existing practices.

  6. The Change of Financial Environment and the Evolvement of Financial Goals

    Directory of Open Access Journals (Sweden)

    Jianhui Jian

    2009-03-01

    Full Text Available With the changing financial environment, financial goals are constantly changing. In the course of development of financial theory, there were numerous financial goals theories, which are mainly "profit maximization, shareholders’ wealth maximization, and stakeholders’ wealth maximization." These financial goals basically reflect the business requirements of the market environment, the adaptation to the changing financial environment, and also reflect the different preferences of the different periods of property rights.

  7. Flight crew fatigue management in a more flexible regulatory environment: an overview of the New Zealand aviation industry.

    Science.gov (United States)

    Signal, T Leigh; Ratieta, Denise; Gander, Philippa H

    2008-04-01

    of more flexible regulatory options has not greatly changed fatigue management practices, although some operators have implemented innovative strategies. The findings suggest a need to raise the level of knowledge within the industry regarding the causes and consequences of fatigue and of processes for its management. This is further supported by the discrepancies between the responses of line pilots and managers, which raise doubts about the effectiveness of some strategies nominally being employed. The regulator and other relevant industry groups should consider how to move the industry toward a mature safety culture and solid knowledge base because these are fundamental to more flexible fatigue management regimes, as is adequate regulatory knowledge, support, and oversight. PMID:18484369

  8. Northern hydrology and water resources in a changing environment

    International Nuclear Information System (INIS)

    The role that climatic change may play in altering various components of the hydrologic cycle in Arctic regions is discussed. The hydrologic setting of these regions is first described, noting the importance of subsurface freezing and thawing on hydrologic pathways and the lack of incorporation of soil freezing and thawing into climate models. Major processes of interest in the relation between climate change and hydrology are the timing and magnitude of fluxes entering and leaving a basin: precipitation, evaporation and transpiration, and runoff. The active layer of the soil could be drastically increased by only a few degrees of surface warming. The natural hydrologic cycle has considerable yearly variation, tending to mask any hydrologic changes caused by climatic change. There are too many unknowns at present for an adequate prediction of the impact of climate change on the hydrologic cycle. The biggest uncertainty is how the timing and quantity of precipitation is going to change. This quantity could be altered by any major changes in vegetation, which would be closely related to the amount of warming. In hydrologic scenarios where air temperature rises 4 degree C over 50 y, under stable, high, and low precipitation conditions, there are no significant changes in hydrologic response. 24 refs., 6 figs

  9. Sugarcane ethanol: contributions to climate change mitigation and the environment

    NARCIS (Netherlands)

    Zuurbier, P.J.P.; Vooren, van de J.G.

    2008-01-01

    Climate change is a challenge facing human life. It will change mobility and asks for new energy solutions. Bioenergy has gained increased attention as an alternative to fossil fuels. Energy based on renewable sources may offer part of the solution. Bio ethanol based on sugar cane offers advantages

  10. Current and new developments in transport and regulatory issues concerning radioisotopes: managing change for minimum business impact

    Science.gov (United States)

    Bennett, Neil; Coppell, David; Rogers, David; Schrader, John

    2004-09-01

    Changes in the regulatory framework governing the Radiation Processing Industry have the potential to make a real business impact on day-to-day profitability. Many areas of the Radiation Processing Industry are affected by changes in the regulatory framework within which these areas are managed. When planning for such changes the transportation element in the shipment of sealed cobalt radiation sources is an area that is often neglected by some parts of the distribution chain. A balance must be struck between the cobalt supplier and the facility operator/customer that rests upon how much the customer needs to know about the intricacies of cobalt shipment. The objective of this paper is to highlight areas of possible business impact and reassure the users of sealed radiation sources that the global suppliers of these products are used to negotiating local variations in regulations governing the physical transportation of radiation sources, changes in regulations governing the design, manufacture and use of transportation containers and changes in the availability of commercial shippers and shipping routes. The major suppliers of industrial quantities of cobalt-60 are well placed to lead their customers through this complex process as a matter of routine.

  11. Current and new developments in transport and regulatory issues concerning radioisotopes: managing change for minimum business impact

    International Nuclear Information System (INIS)

    Changes in the regulatory framework governing the Radiation Processing Industry have the potential to make a real business impact on day-to-day profitability. Many areas of the Radiation Processing Industry are affected by changes in the regulatory framework within which these areas are managed. When planning for such changes the transportation element in the shipment of sealed cobalt radiation sources is an area that is often neglected by some parts of the distribution chain. A balance must be struck between the cobalt supplier and the facility operator/customer that rests upon how much the customer needs to know about the intricacies of cobalt shipment. The objective of this paper is to highlight areas of possible business impact and reassure the users of sealed radiation sources that the global suppliers of these products are used to negotiating local variations in regulations governing the physical transportation of radiation sources, changes in regulations governing the design, manufacture and use of transportation containers and changes in the availability of commercial shippers and shipping routes. The major suppliers of industrial quantities of cobalt-60 are well placed to lead their customers through this complex process as a matter of routine

  12. Changing the regulation for regulating the change: Innovation-driven regulatory developments for smart grids, smart metering and e-mobility in Italy

    International Nuclear Information System (INIS)

    For a long time considered as technologically mature, electric systems are now facing a period of rapid evolution, inspired by climate change concerns. Several studies show that current regulation of natural monopolies does not offer sufficient incentives for network operators (and network users) to participate in this process. Taking Italy as a case study, this paper analyses how energy regulation can change to support the current transformation. We describe the recent regulatory interventions in the domain of smart grids, smart metering and electromobility, with a specific emphasis on the provisions aimed at fostering innovation—an issue that until recently has received almost no attention in the literature nor in the practice of regulation. The progress we observe is considerable in all new areas of concern, and, above all, in the regulator's commitment to provide the right incentives for investments in demonstration projects: the acquisition of experience is regarded as essential to move to more sophisticated regulatory instruments. Finally, regulation is also increasingly concerned with network users, both traditional and new, with the objective to stimulate more active behaviours. - Highlights: ► Regulatory changes in Italy: smart grids, smart metering and electromobility. ► Identification of indicators for regulating innovative investments. ► Demonstration projects for smart grids and EV recharging infrastructures. ► Proposal of an output-based regulation for smart grids. ► Time of Use pricing for residential and small commercial consumers

  13. Simulation of machine interference in randomly changing environments

    Directory of Open Access Journals (Sweden)

    Sztrik J.

    2002-01-01

    Full Text Available The simulation tool lcpSim can be used to investigate special level crossing problems of queuing systems of type HYPOk / HYPOr / 1 // n embedded in different Markovian environments (recently referred to as Markov modulated ones. Our observed system consists of n heterogeneous machines (requests and a server that 'repairs' the broken machines according to the most commonly used service disciplines, such as FIFO, LIFO, PPS, HOL, Preemptive Priorities (Resume, Repeat, Transfer, Polling, Nearest. We specify a maximum number of stopped machines for an operating system and our aim is to give the main steady-state performance measures of the system, such as, server utilization, machine utilization, mean waiting times, mean response times, the probability of an operating system and the mean operating time of the system. These values can be calculated by lcpSim level crossing problem Simulation package for different random environment types and service disciplines.

  14. Flexibility in animal signals facilitates adaptation to rapidly changing environments.

    Directory of Open Access Journals (Sweden)

    Darren S Proppe

    Full Text Available Charles Darwin posited that secondary sexual characteristics result from competition to attract mates. In male songbirds, specialized vocalizations represent secondary sexual characteristics of particular importance because females prefer songs at specific frequencies, amplitudes, and duration. For birds living in human-dominated landscapes, historic selection for song characteristics that convey fitness may compete with novel selective pressures from anthropogenic noise. Here we show that black-capped chickadees (Poecile atricapillus use shorter, higher-frequency songs when traffic noise is high, and longer, lower-frequency songs when noise abates. We suggest that chickadees balance opposing selective pressures by use low-frequency songs to preserve vocal characteristics of dominance that repel competitors and attract females, and high frequency songs to increase song transmission when their environment is noisy. The remarkable vocal flexibility exhibited by chickadees may be one reason that they thrive in urban environments, and such flexibility may also support subsequent genetic adaptation to an increasingly urbanized world.

  15. Organizing corruption controls after a scandal: Regaining legitimacy in complex and changing institutional environments

    OpenAIRE

    Schembera, Stefan; Scherer, Andreas

    2014-01-01

    We study the corruption control strategies at three Multinational companies (MNC) before, during, and after the disclosure of corruption scandals and the initiation of legal procedures. In particular, we want to explore why some MNCs after a corruption scandal exceed regulatory expectations, choose proactive strategies, and influence their environment as institutional entrepreneurs that define best practices and new industry standards. Other companies, by contrast, act in a more incremental a...

  16. Climate change, adaptation and the environment in central Vietnam

    DEFF Research Database (Denmark)

    Bruun, Ole; Casse, Thorkil

    2013-01-01

    There is an urgent need for integrated approaches, such as the building of environmental management into climate change responses, addressing the total impact of livelihood stresses in social vulnerability perspectives, and ensuring that overall adaptation policies adequately address social justice...

  17. Uncertainty and learning in a strategic environment. Global climate change

    International Nuclear Information System (INIS)

    Global climate change is rife with uncertainties. Yet, we can expect to resolve much of this uncertainty in the next 100 years or so. Therefore, current actions should reflect the value of flexibility. Nevertheless, most models of climate change, particularly game-theoretic models, abstract from uncertainty. A model of the impacts of uncertainty and learning in a non-cooperative game shows that the level of correlation of damages across countries is crucial for determining optimal policy

  18. How Changes in the Federal Register Can Help Improve Regulatory Accountability

    OpenAIRE

    Hahn, Robert W.

    1998-01-01

    See Hahn for a more recent analysis published in the Administrative Law Review. Congress has recently become more receptive to using economic analysis in regulatory decisionmaking. To improve regulation, an important first step is to provide useful information that is accessible to the public and other interested parties. The government is an essential source of that information for many federal regulations. Within the government, a central repository of information on regulation is the Feder...

  19. Public institutions and private transactions : the legal and regulatory environment for business private transactions in Brazil and Chile

    OpenAIRE

    Stone, Andrew; Levy, Brian; Paredes, Ricardo

    1992-01-01

    Drawing on the new institutional economics, the authors examine the impact on businesses of Brazil's relatively complex, nontransparent legal and regulatory institutions and compare their costs with those of Chile's institutions, which are relatively simple. They examine four basic areas where legal and regulatory institutions could create critical obstacles to efficiency in the garment industries of Sao Paulo and Santiago: (a) the start-up of a new business (entry); (b) the regulation of bus...

  20. Effect of climatic change on surface environments in the typical region of Horqin Sandy Land

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The town of Agura,a typical region in Horqin Sandy Land,was selected as the study area in this paper.Using 12 remote sensing images and climatic data from the past 20 years,the effects of climate change on surface environments were analyzed.The impact indices of climatic factors,along with their corresponding ranks,were used to characterize the responses of different types of surface environments to climate change.Results show that in the past 20 years,the surface environments of the study area have been deteriorating.Furthermore,there is a positive relationship between the changes in surface environments and those in climatic factors.Various climatic factors influence surface environments in different ways and at different levels.The most sensitive factor is relative humidity,followed by precipitation and evaporation.Overall,moisture is the key factor that affects the changes in surface environments of arid and semi-arid areas.

  1. The Networked University: The Structure, Culture, and Policy of Universities in a Changing Environment

    Science.gov (United States)

    de Wit, Kurt

    2010-01-01

    The universities in Europe are finding themselves in a turbulent environment. They are exposed to global and European developments. This article links changes in the structure, culture, and policy of universities to these developments and changes in the broader-than-national environment. The central question is, in short: what is globalisation…

  2. Amphibian immune defenses against chytridiomycosis: impacts of changing environments.

    Science.gov (United States)

    Rollins-Smith, Louise A; Ramsey, Jeremy P; Pask, James D; Reinert, Laura K; Woodhams, Douglas C

    2011-10-01

    Eco-immunology is the field of study that attempts to understand the functions of the immune system in the context of the host's environment. Amphibians are currently suffering devastating declines and extinctions in nearly all parts of the world due to the emerging infectious disease chytridiomycosis caused by the chytrid fungus, Batrachochytrium dendrobatidis. Because chytridiomycosis is a skin infection and remains confined to the skin, immune defenses of the skin are critical for survival. Skin defenses include secreted antimicrobial peptides and immunoglobulins as well as antifungal metabolites produced by symbiotic skin bacteria. Low temperatures, toxic chemicals, and stress inhibit the immune system and may impair natural defenses against B. dendrobatidis. Tadpoles' mouth parts can be infected by B. dendrobatidis. Damage to the mouth parts can impair growth, and the affected tadpoles maintain the pathogen in the environment even when adults have dispersed. Newly metamorphosing frogs appear to be especially vulnerable to infection and to the lethal effects of this pathogen because the immune system undergoes a dramatic reorganization at metamorphosis, and postmetamorphic defenses are not yet mature. Here we review our current understanding of amphibian immune defenses against B. dendrobatidis and the ability of the pathogen to resist those defenses. We also briefly review what is known about the impacts of temperature, environmental chemicals, and stress on the host-pathogen interactions and suggest future directions for research. PMID:21816807

  3. Sino-Japanese Teamwork Probes Environment Changes on Tibetan Plateau

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ With the support of a CAS project on Holocene environmental changes and their influences on the ecosystem of the Tibetan Plateau, a research group headed by Prof. Zhu Liping from the CAS Institute of Tibetan Plateau Research and their Japanese collaborators carried out a field survey in Puma Yumco area on the Tibetan Plateau from September 8 to 20.

  4. Communicating Climate Change to Visitors of Informal Science Environments

    Science.gov (United States)

    Koepfler, Jes A.; Heimlich, Joe E.; Yocco, Victor S.

    2010-01-01

    This article reports findings on visitors' preferences for content presentation of a future global warming and climate change exhibit. The study was conducted with two groups: one from the Marian Koshland Science Museum of the National Academy of Sciences in Washington, DC, and the other at the Center of Science and Industry in Columbus, Ohio. The…

  5. Changing heartbeat perception to induce anxiety in virtual environments.

    Science.gov (United States)

    Chittaro, Luca

    2012-01-01

    In this paper, we first propose a general technique to induce anxiety in virtual environments (VEs) which exploits auditory heartbeat perception and biofeedback. Then, we consider a VE that reproduces a real-world anxiety-inducing experience (being suddenly surrounded by smoke during a fire evacuation of a building), and we describe an experiment that contrasts 3 conditions: (i) an augmentation of the VE with a bar that indicates when the user's avatar gets hurt, (ii) an augmentation of the VE with the typical audio visual stimuli which are employed in violent videogames when the user's avatar gets hurt, (iii) introduction of the proposed biofeedback technique in the previous condition. We carry out an electrodermal analysis showing that the introduction of the proposed technique produces much higher physiological arousal in terms of skin conductance level (SCL) than the other two conditions. Subjective measures of users' state anxiety are consistent with the recorded physiological reactions. PMID:22954850

  6. Within-woman change in regulatory T cells from pregnancy to the postpartum period

    OpenAIRE

    Wegienka, Ganesa; Havstad, Suzanne; Bobbitt, Kevin R.; Woodcroft, Kimberley J.; Zoratti, Edward M.; Ownby, Dennis R.; Johnson, Christine Cole

    2010-01-01

    Regulatory T cells (Treg cells) are an important area of investigation in human health and disease. In this study, the trajectory of percentage of Treg cells (defined as CD4+CD25+Foxp3+CD127− lymphocytes) was measured in the blood of 208 women during pregnancy and up to 3 additional times in the postpartum period (1, 6 and 12 months postpartum). Whether the trajectory was affected by gravidity, parity, neonatal sex, pet exposure, maternal atopic and asthma status, smoking, maternal race or ot...

  7. Evolutionary neural network learning algorithms for changing environments

    OpenAIRE

    Rocha, Miguel; Cortez, Paulo; Neves, José

    2004-01-01

    Classical Machine Learning methods are usually developed to work in static data sets. Yet, real world data typically changes over time and there is the need to develop novel adaptive learning algorithms. In this work, a number of algorithms, combining Neural Network learning models and Evolutionary Computation optimization techniques, are compared, being held several simulations based on artificial and real world problems. The results favor the combination of evolution and lifetime learning a...

  8. Coastal sedimentary environments and sea-level changes

    OpenAIRE

    Dabrio, C.J.

    2000-01-01

    A detailed knowledge of the 3-D arrangement and lateral facies relationships of the stacking patterns in coastal deposits is essential to approach many geological problems such as precise tracing of sea level changes, particularly during small scale fluctuations. These are useful data regarding the geodynamic evolution of basin margins and yield profit in oil exploration. Sediment supply, wave-and tidal processes, coastal morphology, and accommodation space generated by eustasy and t...

  9. Leveraging Environment and Climate Change Initiatives for Corporate Excellence

    OpenAIRE

    Venkatachalam ANBUMOZHI; Kimura, Mari; Isono, Kumiko

    2011-01-01

    As an integral part of sustainable development, the impacts from climate change, including increasing water stress, more extreme weather events, the potential for high levels of migration and the disruption of international markets are critical challenges for all Asian countries. With rapid economic growth and modernization, the countries in the region are increasing production and consumption, calling for critical adaption measures. With the Asian countries and the energy sector exceedingly ...

  10. Hydrologic predictions in a changing environment: behavioral modeling

    Directory of Open Access Journals (Sweden)

    B. Schaefli

    2010-10-01

    Full Text Available Most hydrological models are valid at most only in a few places and cannot be reasonably transferred to other places or to far distant time periods. Transfer in space is difficult because the models are conditioned on past observations at particular places to define parameter values and unobservable processes that are needed to fully characterize the structure and functioning of the landscape. Transfer in time has to deal with the likely temporal changes to both parameters and processes under future changed conditions. This remains an important obstacle to addressing some of the most urgent prediction questions in hydrology, such as prediction in ungauged basins and prediction under global change. In this paper, we propose a new approach to catchment hydrological modeling, based on universal principles that do not change in time and that remain valid across many places. The key to this framework, which we call behavioral modeling, is to assume that these universal and time-invariant organizing principles can be used to identify the most appropriate model structure (including parameter values and responses for a given ecosystem at a given moment in time. The organizing principles may be derived from fundamental physical or biological laws, or from empirical laws that have been demonstrated to be time-invariant and to hold at many places and scales. Much fundamental research remains to be undertaken to help discover these organizing principles on the basis of exploration of observed patterns of landscape structure and hydrological behavior and their interpretation as legacy effects of past co-evolution of climate, soils, topography, vegetation and humans. Our hope is that the new behavioral modeling framework will be a step forward towards a new vision for hydrology where models are capable of more confidently predicting the behavior of catchments beyond what has been observed or experienced before.

  11. Adaptive wetland management in an uncertain and changing arid environment

    OpenAIRE

    Rebekah Downard; Joanna Endter-Wada; Kettenring, Karin M.

    2014-01-01

    Wetlands in the arid western United States provide rare and critical migratory bird habitat and constitute a critical nexus within larger social-ecological systems (SES) where multiple changing land-use and water-use patterns meet. The Bear River Migratory Bird Refuge in Utah, USA, presents a case study of the ways that wetland managers have created adaptive management strategies that are responsive to the social and hydrological conditions of the agriculture-dominated SES within which they a...

  12. INIST : Tracking Grey Literature in a Changing Environment

    OpenAIRE

    Schöpfel, Joachim; GreyNet, Grey Literature Network Service

    2000-01-01

    The Institute of Scientific & Technical Information (INIST, www.inist.fr), founded in '88 and part of the French National Center for Scientific Research (CNRS, www.cnrs.fr), is a major public database producer (Pascal, Francis) and document supply center. Since 1998, INIST has engaged in a collective reflection on its databases, services and acquisition policy to face up with electronic document and rapidly changing needs. Our approach to "non-conventional literature" (reports, theses, confer...

  13. Mining and the environment: driving forces for change

    International Nuclear Information System (INIS)

    Public perceptions of the mining industry and its environmental, economic and socio-cultural impacts are of basic importance with regard to the development of regulations and of company strategies. Identifying those public attitudes (expressed either formally or informally) that will become widespread forces for change can be difficult, as can choosing the correct response. There is a need for the industry as a whole to define generally applicable social and environmental principles. (author)

  14. Greenhouse gases: Changing the nature of our environment

    International Nuclear Information System (INIS)

    Emissions of carbon dioxide and other agriculturally, industrially, and energy-related gases are altering the composition of the atmosphere in a manner that will enhance the trapping of infrared radiation and lend to increasing global average temperatures. Analysis of the historical climate record is under way to identify evidence that the changes in atmospheric concentration to data have already initiated the model-predicted warming. Observations suggest that the global average temperature has risen ∼0.5 ± 0.2 degree C over the past 150 yr, which is, depending on how account is taken of the ocean heat lag and of natural variability, roughly consistent with the lower half of the model-estimated range. The most recent model estimates are, however, in the upper half of this range, suggesting a factor of 2 disagreement and prompting intensive studies of the role of clouds in influencing climate change. What is certain is that the atmospheric composition is changing and that climate will respond, almost certainly by a few-degrees warming if emissions continue unabated. Reducing the uncertainties and refining estimates of impacts to the point where energy and other policies may be affected, however, poses a significant research challenge

  15. Changing Environments by Changing Individuals: The Emergent Effects of Psychological Intervention.

    Science.gov (United States)

    Powers, Joseph T; Cook, Jonathan E; Purdie-Vaughns, Valerie; Garcia, Julio; Apfel, Nancy; Cohen, Geoffrey L

    2016-02-01

    The two studies reported here tested whether a classroom-based psychological intervention that benefited a few African American 7th graders could trigger emergent ecological effects that benefited their entire classrooms. Multilevel analyses were conducted on data that previously documented the benefits of values affirmations on African American students' grades. The density of African American students who received the intervention in each classroom (i.e., treatment density) was used as an independent predictor of grades. Within a classroom, the greater the density of African American students who participated in the intervention exercise, the higher the grades of all classmates on average, regardless of their race or whether they participated in the intervention exercise. Benefits of treatment density were most pronounced among students with a history of poor performance. Results suggest that the benefits of psychological intervention do not end with the individual. Changed individuals can improve their social environments, and such improvements can benefit others regardless of whether they participated in the intervention. These findings have implications for understanding the emergence of ecological consequences from psychological processes. PMID:26671909

  16. A Comment on the environment and directed technical change

    Energy Technology Data Exchange (ETDEWEB)

    Greaker, Mads; Heggedal, Tom-Reiel

    2012-07-01

    The major claim in Acemoglu, Aghion, Bursztyn and Hemous (2012) (AABH) is that subsidies for research and development of clean technologies are more important than carbon taxes when dealing with climate change. However, they – unconventionally – assume that a patent only lasts for one period. In this note we introduce long-lived patents into the AABH model. This makes the role of a research subsidy for clean technologies in AABH far less crucial and reestablishes the role of the carbon tax. This is good news as it is far easier to tax emissions than to pick the right technologies to subsidize.(Author)

  17. Climate change and the cultural environment: Recognized impacts challenges in Finland

    OpenAIRE

    BerghÀll, Jonna; Pesu, Minna

    2008-01-01

    Climate change impacts the cultural heritage of Finland. Adaptation and mitigation measures are posing challenges along with the consequences of climate change. Cultural landscapes, the built cultural environment and the archaeological heritage all will be affected. The impacts of climate change that Finland will face and the challenges posed by them for the care of the cultural environment also apply to the Boreal Zone of Northern Europe in more general terms. This report charts the chall...

  18. Developing Frameworks for Studies on Sedimentary Fluxes and Budgets in Changing Cold Environments

    OpenAIRE

    Beylich A. Achim; Lamoureux F. Scott; Decaulne Armelle

    2011-01-01

    Geomorphic processes that are responsible for the transfer of sediments and landform change are highly dependent on climate and vegetation cover. It is anticipated that climate change will have a major impact on the behaviour of Earth surface systems and that the most profound changes will occur in high-latitude and high-altitude cold environments. Collection, comparison and evaluation of data from a range of different high-latitude and high-altitude cold environments are required to permit g...

  19. Breeding blueberries for a changing global environment: a review

    Directory of Open Access Journals (Sweden)

    Gustavo A. Lobos

    2015-09-01

    Full Text Available Today, blueberries are recognized worldwide as one of the foremost health foods, becoming one of the crops with the highest productive and commercial projections. Over the last hundred years, the geographical area where highbush blueberries are grown has extended dramatically into hotter and drier environments. The expansion of highbush blueberry growing into warmer regions will be challenged in the future by increases in average global temperature and extreme fluctuations in temperature and rainfall patterns. Considerable genetic variability exists within the blueberry gene pool that breeders can use to meet these challenges, but traditional selection techniques can be slow and inefficient and the precise adaptations of genotypes often remain hidden. Marker assisted breeding (MAB and phenomics could aid greatly in identifying those individuals carrying adventitious traits, increasing selection efficiency and shortening the rate of cultivar release. While phenomics have begun to be used in the breeding of grain crops in the last 10 years, their use in fruit breeding programs it is almost non-existent.

  20. Transhumance Farming in Swiss Mountains: Adaptation to a Changing Environment

    Directory of Open Access Journals (Sweden)

    Christine Jurt

    2015-02-01

    Full Text Available Families living on transhumance farms (Stufenbetriebe in the Swiss Alps may move with their cattle up to 12 times a year between as many as 4 altitudinal levels. Transhumance farms have come under increasing political pressure to improve their economic performance, which has been hampered by a number of factors, such as rising infrastructure costs for meeting animal welfare regulations at multiple farm locations, lack of access roads, and restrictions on the creation of new transhumance farms. Little is known about transhumant farming practices and the role they play in mountain regions. In this exploratory anthropological study, we interviewed 39 transhumance farm family members in 7 Swiss cantons about their history, present situation, and visions of the future. A special focus was the risk perceptions upon which decisions and management strategies are based. The semistructured interviews were analyzed according to principles of content analysis and risk network analysis, with a focus on social, cultural, economic, and political risks as well as natural hazards. The results show that many transhumance farms are undergoing a process of adaptation to a changing social, political, economic, environmental, and cultural context. Transhumance farming has allowed individuals to survive as mountain farmers despite often difficult conditions. This study offers important insights into the risk perceptions and strategies of adaptation to ongoing changes developed by the families on these farms.

  1. Plant adaptation to dynamically changing environment: the shade avoidance response.

    Science.gov (United States)

    Ruberti, I; Sessa, G; Ciolfi, A; Possenti, M; Carabelli, M; Morelli, G

    2012-01-01

    The success of competitive interactions between plants determines the chance of survival of individuals and eventually of whole plant species. Shade-tolerant plants have adapted their photosynthesis to function optimally under low-light conditions. These plants are therefore capable of long-term survival under a canopy shade. In contrast, shade-avoiding plants adapt their growth to perceive maximum sunlight and therefore rapidly dominate gaps in a canopy. Daylight contains roughly equal proportions of red and far-red light, but within vegetation that ratio is lowered as a result of red absorption by photosynthetic pigments. This light quality change is perceived through the phytochrome system as an unambiguous signal of the proximity of neighbors resulting in a suite of developmental responses (termed the shade avoidance response) that, when successful, result in the overgrowth of those neighbors. Shoot elongation induced by low red/far-red light may confer high relative fitness in natural dense communities. However, since elongation is often achieved at the expense of leaf and root growth, shade avoidance may lead to reduction in crop plant productivity. Over the past decade, major progresses have been achieved in the understanding of the molecular basis of shade avoidance. However, uncovering the mechanisms underpinning plant response and adaptation to changes in the ratio of red to far-red light is key to design new strategies to precise modulate shade avoidance in time and space without impairing the overall crop ability to compete for light. PMID:21888962

  2. On the world's ice ages and changing environments

    International Nuclear Information System (INIS)

    All known ice ages during the earth's history are reviewed. The oldest glaciation occurred around 2.3 billion years ago, followed by a series of large glaciations 950-650, 450-430 and 310-270 million years ago. Continental drift played a major role in these long-term climatic changes. The present Quaternary ice age actually began 17 million years ago, when a large ice mass grew over Antarctica. A detailed account is given of the climatic fluctuations during the Quaternary period (over 2.5 million years). Different stratigraphic records, and the relationship of climatic variations to orbital forcing are discussed. Large environmental changes took place in the course of the climate oscillations. Large ice sheets waxed and waned, global sea-levels fluctuated, forests disappeared from many regions during cold times and advanced during favourable times. The ice masses depressed the earth's crust markedly, and this then rose rapidly when the ice melted. The extent of glacial erosion is also discussed. Finally the postglacial climatic history of the earth is described and the consequences of the possible greenhouse effect are considered.(orig.)

  3. Changes in macrophage function modulated by the lipid environment.

    Science.gov (United States)

    Williams, Michael R; Cauvi, David M; Rivera, Isabel; Hawisher, Dennis; De Maio, Antonio

    2016-04-01

    Macrophages (Mφs) play a critical role in the defense against pathogens, orchestrating the inflammatory response during injury and maintaining tissue homeostasis. During these processes, macrophages encounter a variety of environmental conditions that are likely to change their gene expression pattern, which modulates their function. In this study, we found that murine Mφs displayed two different subpopulations characterized by differences in morphologies, expression of surface markers and phagocytic capacity under non-stimulated conditions. These two subpopulations could be recapitulated by changes in the culture conditions. Thus, Mφs grown in suspension in the presence of serum were highly phagocytic, whereas subtraction of serum resulted in rapid attachment and reduced phagocytic activity. The difference in phagocytosis between these subpopulations was correlated with the expression levels of FcγR. These two cell subpopulations also differed in their responses to LPS and the expression of surface markers, including CD14, CD86, scavenger receptor A1, TLR4 and low-density lipoprotein receptor. Moreover, we found that the lipid/cholesterol content in the culture medium mediated the differences between these two cell subpopulations. Thus, we described a mechanism that modulates Mφ function depending on the exposure to lipids within their surrounding microenvironment. PMID:26951856

  4. Adaptive wetland management in an uncertain and changing arid environment

    Directory of Open Access Journals (Sweden)

    Rebekah Downard

    2014-06-01

    Full Text Available Wetlands in the arid western United States provide rare and critical migratory bird habitat and constitute a critical nexus within larger social-ecological systems (SES where multiple changing land-use and water-use patterns meet. The Bear River Migratory Bird Refuge in Utah, USA, presents a case study of the ways that wetland managers have created adaptive management strategies that are responsive to the social and hydrological conditions of the agriculture-dominated SES within which they are located. Managers have acquired water rights and constructed infrastructure while cultivating collaborative relationships with other water users to increase the adaptive capacity of the region and decrease conflict. Historically, water management involved diversion and impoundment of water within wetland units timed around patterns of agricultural water needs. In the last 20 years, managers have learned from flood and drought events and developed a long-term adaptive management plan that specifies alternative management actions managers can choose each year based on habitat needs and projected water supply. Each alternative includes habitat goals and target wetland water depth. However, wetland management adapted to agricultural return-flow availability may prove insufficient as population growth and climate change alter patterns of land and water use. Future management will likely depend more on negotiation, collaboration, and learning from social developments within the SES than strictly focusing on water management within refuge boundaries. To face this problem, managers have worked to be included in negotiations with regional water users, a strategy that may prove instructive for other wetland managers in agriculture-dominated watersheds.

  5. Changes of CD8+CD28- T regulatory cells in rat model of colitis induced by 2,4-dinitrofluorobenzene

    Institute of Scientific and Technical Information of China (English)

    Wen-Bin Xiao; Yu-Lan Liu

    2003-01-01

    AIM: To determine the changes of CD8+ T subsets especially CD8+CD28- T regulatory cells in rat model of experimental colitis induced by 2,4-dinitrofiuorobenzene (DNFB).METHODS: The rat model of experimental colitis was induced by enema with DNFB. Ten days later, colonic intraepithelial and splenic lymphocytes were isolated from colitis animals (n=16) and controls (n=8). The proportion of CD8+ T cells, CD8+CD28+ T cells and CD8+CD28- T regulatory cells were determined by flow cytometry.RESULTS: The model of experimental colitis was successfully established by DNFB that was demonstrated by bloody diarrhea, weight loss and colonic histopathology. The proportion of CD8+ T cells in either splenic or colonic intraepithelial lymphocytes was not significantly different between colitis animals and controls (spleen: 34.6±7.24 % vs33.5±9.41%,colon: 14.0±8.93 % vs 18.0±4.06 %, P>0.05). But CD8+CD28-T regulatory cells from colitis animals were significantly more than those from controls (spleen: 11.3±2.26 % vs5.64±1.01%,colon: 6.50±5.37 % vs 1.07±0.65 %, P<0.05). In contrast,CD8+CD28+ T cells from colitis animals were less than those from controls (spleen: 23.3±6.14 % vs27.8±9.70 %, P=0.06;colon: 7.52±4.18 % vs 16.9±4.07 %, P<0.05). The proportion of CD8+CD28- T regulatory cells in splenic and colonintraepithelial CD8+ T cells from colitis animals was higher than that from controls (spleen: 33.3±5.49 % vs 18.4±7.26 %,colon: 46.0±14.3 % vs6.10±3.72 %, P<0.005).CONCLUSION: Experimental colitis of rats can be induced by DNFB with simplicity and good reproducibility. The proportion of CD8+CD28- T regulatory cells in rats with experimental colitis is increased, which may be associated with the pathogenesis of colitis.

  6. Drought early warning and risk management in a changing environment

    Science.gov (United States)

    Pulwarty, R. S.

    2011-12-01

    Drought has long been recognized as falling into the category of incremental but long-term and cumulative environmental changes, also termed slow-onset or creeping events. These event types would include: air and water quality decline, desertification processes, deforestation and forest fragmentation, loss of biodiversity and habitats, and nitrogen overloading, among others. Climate scientists continue to struggle with recognizing the onset of drought and scientists and policy makers continue to debate the basis (i.e., criteria) for declaring an end to a drought. Risk-based management approaches to drought planning at the national and regional levels have been recommended repeatedly over the years but their prototyping, testing and operational implementation have been limited. This presentation will outline two avenues for disaster risk reduction in the context of drought (1) integrated early warning information systems, and (2) linking disaster risk reduction to climate change adaptation strategies. Adaptation involves not only using operational facilities and infrastructure to cope with the immediate problems but also leaving slack or reserve for coping with multiple stress problems that produce extreme impacts and surprise. Increasing the 'anticipatability' of an event, involves both monitoring of key indicators from appropriate baseline data, and observing early warning signs that assumptions in risk management plans are failing and critical transitions are occurring. Illustrative cases will be drawn from the IPCC Special Report on Managing the Risks of Extreme Events and Disasters (2011), the UN Global Assessment of Disaster Risk Reduction (2011) and implementation activities in which the author has been engaged. Most drought early warning systems have tended to focus on the development and use of physical system indicators and forecasts of trends and thresholds. We show that successful early warning systems that meet expectations of risk management also have

  7. Strengthening CERN and particle physics in a changing global environment

    CERN Multimedia

    2016-01-01

    As we welcome Romania as our 22nd Member State in late July, now is a good time to reflect on the geographical enlargement process that was initiated in 2010.   Let me begin by setting the context. CERN operates in an increasingly complex and globalised world. Political and economic developments in the European neighbourhood and well beyond can have an impact on our work – directly or indirectly, in the short term or in a much longer perspective. We need to anticipate that change as far as we can, while also being agile enough to meet the challenges that we do not expect. The UK’s EU referendum on 23 June is a case in point. Because CERN is an organisation founded to facilitate cooperation across borders, Brexit is an uncomfortable truth to many of us. It is, nevertheless, the outcome of the political processes of one of our founding Member States, and is something we must respect. Whatever direction the UK now takes, we will be working with the country’s particle ph...

  8. Physiological changes, sleep, and morning mood in an isolated environment

    Science.gov (United States)

    Kraft, Norbert O.; Inoue, Natsuhiko; Mizuno, Koh; Ohshima, Hiroshi; Murai, Tadashi; Sekiguchi, Chiharu; Orasanu, J. M. (Principal Investigator)

    2002-01-01

    BACKGROUND: Previous isolation studies have shown increased 24-h urine volumes and body weight gains in subjects. This project examined those and other physiological variables in relationship to sleep motor activity, subjective sleep quality, mood, and complaints during confinement. METHODS: Six male and two female subjects lived for 7 d in the National Space Development Agency of Japan's isolation chamber, which simulates the interior of the Japanese Experiment Module. Each 24-h period included 6 h of sleep, 3 meals, and 20 min of exercise. Each morning, subjects completed Sleep Sensation and Complaint Index questionnaires. Catecholamine and creatinine excretion, urine volume, and body weight were measured on the 2 d before and 2 d after confinement, and sleep motor activity was measured during confinement. RESULTS: Confinement produced no significant change in body weight, urine volume, or questionnaire results. In contrast, epinephrine, norepinephrine, and sleep motor activity exhibited significant differences during confinement (p subjects working under time-stress. High sympathetic activity (as indicated by norepinephrine) may have interfered with sleep.

  9. Physiological changes, sleep, and morning mood in an isolated environment

    Science.gov (United States)

    Kraft, Norbert O.; Inoue, Natsuhiko; Mizuno, Koh; Ohshima, Hiroshi; Murai, Tadashi; Sekiguchi, Chiharu; Orasanu, J. M. (Principal Investigator)

    2002-01-01

    BACKGROUND: Previous isolation studies have shown increased 24-h urine volumes and body weight gains in subjects. This project examined those and other physiological variables in relationship to sleep motor activity, subjective sleep quality, mood, and complaints during confinement. METHODS: Six male and two female subjects lived for 7 d in the National Space Development Agency of Japan's isolation chamber, which simulates the interior of the Japanese Experiment Module. Each 24-h period included 6 h of sleep, 3 meals, and 20 min of exercise. Each morning, subjects completed Sleep Sensation and Complaint Index questionnaires. Catecholamine and creatinine excretion, urine volume, and body weight were measured on the 2 d before and 2 d after confinement, and sleep motor activity was measured during confinement. RESULTS: Confinement produced no significant change in body weight, urine volume, or questionnaire results. In contrast, epinephrine, norepinephrine, and sleep motor activity exhibited significant differences during confinement (p sleep motor activity. CONCLUSION: The 24-h epinephrine values were slightly higher than normal throughout the experiment, but lower than for subjects working under time-stress. High sympathetic activity (as indicated by norepinephrine) may have interfered with sleep.

  10. Respiratory changes due to extreme cold in the Arctic environment

    Science.gov (United States)

    Bandopadhyay, P.; Selvamurthy, W.

    1993-03-01

    Effects of acute exposure and acclimatisation to cold stress on respiratory functions were investigated in healthy tropical Indian men ( n=10). Initial baseline recordings were carried out at Delhi and thereafter serially thrice at the arctic region and once on return to Delhi. For comparison the respiratory functions were also evaluated on Russian migrants (RM; n=7) and Russian natives (RN; n=6). The respiratory functions were evaluated using standard methodology on a Vitalograph: In Indians, there was an initial decrease in lung vital capacity (VC), forced vital capacity (FVC), forced expiratory volume 1st s (FEV1), peak expiratory flow rate (PEFR) and maximum voluntary ventilation (MVV) on acute exposure to cold stress, followed by gradual recovery during acclimatisation for 4 weeks and a further significant improvement after 9 weeks of stay at the arctic region. On return to India all the parameters reached near baseline values except for MVV which remained slightly elevated. RM and RN showed similar respiratory functions at the beginning of acute cold exposure at the arctic zone. RN showed an improvement after 10 weeks of stay whereas RM did not show much change. The respiratory responses during acute cold exposure are similar to those of initial altitude responses.

  11. Physiological changes, sleep, and morning mood in an isolated environment

    Science.gov (United States)

    Kraft, Norbert O.; Inoue, Natsuhiko; Mizuno, Koh; Ohshima, Hiroshi; Murai, Tadashi; Sekiguchi, Chiharu; Orasanu, J. M. (Principal Investigator)

    2002-01-01

    BACKGROUND: Previous isolation studies have shown increased 24-h urine volumes and body weight gains in subjects. This project examined those and other physiological variables in relationship to sleep motor activity, subjective sleep quality, mood, and complaints during confinement. METHODS: Six male and two female subjects lived for 7 d in the National Space Development Agency of Japan's isolation chamber, which simulates the interior of the Japanese Experiment Module. Each 24-h period included 6 h of sleep, 3 meals, and 20 min of exercise. Each morning, subjects completed Sleep Sensation and Complaint Index questionnaires. Catecholamine and creatinine excretion, urine volume, and body weight were measured on the 2 d before and 2 d after confinement, and sleep motor activity was measured during confinement. RESULTS: Confinement produced no significant change in body weight, urine volume, or questionnaire results. In contrast, epinephrine, norepinephrine, and sleep motor activity exhibited significant differences during confinement (p < 0.05). Higher nocturnal norepinephrine excretion correlated with higher sleep motor activity. CONCLUSION: The 24-h epinephrine values were slightly higher than normal throughout the experiment, but lower than for subjects working under time-stress. High sympathetic activity (as indicated by norepinephrine) may have interfered with sleep.

  12. Statistical modelling of masked gene regulatory pathway changes across microarray studies of interferon gamma activated macrophages

    OpenAIRE

    Forster, Thorsten

    2014-01-01

    Interferon gamma (IFN-γ) regulation of macrophages plays an essential role in innate immunity and pathogenicity of viral infections by directing large and small genome-wide changes in the transcriptional program of macrophages. Smaller changes at the transcriptional level are difficult to detect but can have profound biological effects, motivating the hypothesis of this thesis that responses of macrophages to immune activation by IFN-γ include small quantitative changes that are m...

  13. Ages of celiac disease: From changing environment to improved diagnostics

    Institute of Scientific and Technical Information of China (English)

    Alberto Tommasini; Tarcisio Not; Alessandro Ventura

    2011-01-01

    From the time of Gee's landmark writings, the recent history of celiac disease (CD) can be divided into manyages, each driven by a diagnostic advance and a deeperknowledge of disease pathogenesis. At the same time,these advances were paralleled by the identification of new clinical patterns associated with CD and by a continuous redefinition of the prevalence of the diseasein population. In the beginning, CD was considered a chronic indigestion, even if the causative food was notknown; later, the disease was proven to depend on anintolerance to wheat gliadin, leading to typical mucosalchanges in the gut and to a malabsorption syndrome. This knowledge led to curing the disease with a gluten-free diet. After the identification of antibodies to gluten(AGA) in the serum of patients and the identification of gluten-specific lymphocytes in the mucosa, CD was described as an immune disorder, resembling a chronic "gluten infection". The use of serological testing for AGA allowed identification of the higher prevalence of this disorder, revealing atypical patterns of presenta-tion. More recently, the characterization of autoantibod-ies to endomysium and to transglutaminase shifted the attention to a complex autoimmune pathogenesis and to the increased risk of developing autoimmune disor-ders in untreated CD. New diagnostic assays, based on molecular technologies, will introduce new changes, with the promise of better defining the spectrum of gluten reactivity and the real burden of gluten related-disorders in the population. Herein, we describe the different periods of CD experience, and further devel-opments for the next celiac age will be proposed.

  14. Instructional change in academic departments: An analysis from the persepctive of two environment-focused change strategies

    Science.gov (United States)

    Quardokus, Kathleen M.

    Numerous reports demand changes in college and university teaching practices. This is especially true for science, technology, engineering and mathematics (STEM) disciplines. STEM stakeholders are concerned about student retention within STEM majors, as well as the lack of sufficient graduates with the knowledge to advance these fields. A common conclusion of these reports is that teaching practices must change. Although these calls for change have occurred for decades, STEM fields have yet to experience widespread change. Thus, there is a need for more effective change strategies. Recently, researchers have suggested that effective change strategies should focus on changing the environments of academic departments. This is in contrast to most commonly-used change strategies that focus on individual instructors. Environmentfocused change strategies have two main varieties: those that have a goal of implementing prescribed outcomes, and those that expect the outcomes to emerge from the change process. Yet, little is known about how to enact environment-focused change strategies. The goal of this research is to provide guidance for change agents and researchers by analyzing a large-scale change initiative from the perspective of two environment-focused change strategies: Kotter's eight-stage leadership process (prescribed) and complexity leadership theory (emergent). This analysis was guided by two research questions. 1. Within the context of a higher education change initiative, how is the change process described from the perspectives of two distinct leadership theories? 2. How do these descriptions frame problems and solutions associated with change? Each change strategy identified different activities as contributing to change as well as different missed opportunities. For example, when the change vision was not communicated effectively, the eight-stage leadership process indicated that the involvement of the department chair was needed, while complexity

  15. 77 FR 3531 - Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule Change...

    Science.gov (United States)

    2012-01-24

    ... proposed rule change in Section II below. II. Description The rule change will enhance the risk management... To Enhance Risk Management Controls Associated With the Receiver Authorized Delivery Function January... enhance the risk management controls associated with the RAD function to reduce Participant...

  16. Regulatory Implications of Structural Changes in Tyr201 of the Oxygen Sensor Protein FixL.

    Science.gov (United States)

    Yamawaki, Takeo; Ishikawa, Haruto; Mizuno, Misao; Nakamura, Hiro; Shiro, Yoshitsugu; Mizutani, Yasuhisa

    2016-07-26

    FixL is a heme-based oxygen-sensing histidine kinase that induces the expression of nitrogen fixation genes under hypoxic conditions. Oxygen dissociation from heme iron in the sensor domain of FixL initiates protein conformational changes that are transmitted to the histidine kinase domain, activating autophosphorylation activity. Conversely, oxygen binding inhibits FixL kinase activity. It is essential to elucidate the changes that occur in the protein structure upon this oxygen dissociation for understanding of the allosteric transduction mechanism. We measured ultraviolet resonance Raman spectra of FixL and its mutants for deoxy, oxy, and carbonmonoxy forms to examine the changes in protein structure upon oxygen dissociation. The observed spectral changes indicated that Tyr201 and its neighboring residues undergo structural changes upon oxygen dissociation. Kinase assays showed that substitution of Tyr201 significantly decreased the inhibition of kinase activity upon oxygen binding. These data mean that weakening of the hydrogen bond of Tyr201 that is induced by oxygen dissociation is essential for inhibition of kinase activity. We also observed spectral changes in Tyr residues in the kinase domain upon oxygen dissociation from FixL, which is the first observation of oxygen-dependent structural changes in the kinase domain of FixL. The observed structural changes support the allosteric transduction pathway of FixL which we proposed previously [ Yano, S., Ishikawa, H., Mizuno, M., Nakamura, H., Shiro, Y., and Mizutani, Y. ( 2013 ) J. Phys. Chem. B 117 , 15786 - 15791 ]. PMID:27367650

  17. Climate Change and China as a Global Emerging Regulatory Sea Power in the Arctic Ocean

    DEFF Research Database (Denmark)

    Cassotta Pertoldi-Bianchi, Sandra; Hossain, Kamrul; Ren, Jingzheng;

    2015-01-01

    on the Law of the Sea (UNCLOS) and the Arctic Council (AC) are taken into consideration under climate change effects, to assess how global legal frameworks and institutions can deal with China’s strategy in the Arctic Ocean. China’s is moving away from its role as “humble power” to one of “informal......The impact of climate change in the Arctic Ocean such as ice melting and ice retreat facilitates natural resources extraction. Arctic fossil fuel becomes the drivers of geopolitical changes in the Arctic Ocean. Climate change facilitates natural resource extractions and increases competition...... imperialistic” resulting in substantial impact on the Arctic and Antartic dynamism. Due to ice-melting, an easy access to natural resources, China’s Arctic strategy in the Arctic Ocean has reinforced its military martitime strategy and has profoundly changed its maritime military doctrine shifting from regional...

  18. Enzymatic changes in myosin regulatory proteins may explain vasoplegia in terminally ill patients with sepsis

    Science.gov (United States)

    Zheng, Wentao; Kou, Yong; Gao, Feng-lan; Ouyang, Xiu-he

    2016-01-01

    The current study was conducted with the hypothesis that failure of maintenance of the vascular tone may be central to failure of the peripheral circulation and spiralling down of blood pressure in sepsis. Namely, we examined the balance between expression of myosin light chain (MLC) phosphatase and kinase, enzymes that regulate MLCs dephosphorylation and phosphorylation with a direct effect on pharmacomechanical coupling for smooth muscle relaxation and contraction respectively. Mechanical recordings and enzyme immunoassays of vascular smooth muscle lysates were used as the major methods to examine arterial biopsy samples from terminally ill sepsis patients. The results of the present study provide evidence that genomic alteration of expression of key regulatory proteins in vascular smooth muscles may be responsible for the relentless downhill course in sepsis. Down-regulation of myosin light chain kinase (MLCK) and up-regulation of MLCK may explain the loss of tone and failure to mount contractile response in vivo during circulation. The mechanical studies demonstrated the inability of the arteries to develop tone when stimulated by phenylephrine in vitro. The results of our study provide indirect hint that control of inflammation is a major therapeutic approach in sepsis, and may facilitate to ameliorate the progressive cardiovascular collapse. PMID:26772992

  19. Landscape changes in the environment due to military actions and their epidemic risks

    OpenAIRE

    Krushelnitsky, A. D.; Ogorodniychuk, I. V.; Ivanko, O. M.

    2016-01-01

    The article considers  the influence of the military-ecological and man-caused-anthropogenic factors on the environment state and natural processes. Epidemic risks and consequences resulted from landscapic changes of the environment which arise as a result of war and destruction of ecosystems are described.

  20. Landscape changes in the environment due to military actions and their epidemic risks

    OpenAIRE

    Krushelnitsky A.D.; Ogorodniychuk I.V.; Ivanko O.M.

    2016-01-01

    The article considers the influence of the military-ecological and man-caused-anthropogenic factors on the environment state and natural processes. Epidemic risks and consequences resulted from landscapic changes of the environment which arise as a result of war and destruction of ecosystems are described.

  1. Landscape changes in the environment due to military actions and their epidemic risks

    Directory of Open Access Journals (Sweden)

    Krushelnitsky A.D.

    2016-05-01

    Full Text Available The article considers the influence of the military-ecological and man-caused-anthropogenic factors on the environment state and natural processes. Epidemic risks and consequences resulted from landscapic changes of the environment which arise as a result of war and destruction of ecosystems are described.

  2. Adaptation, plasticity, and extinction in a changing environment: towards a predictive theory.

    Directory of Open Access Journals (Sweden)

    Luis-Miguel Chevin

    Full Text Available Many species are experiencing sustained environmental change mainly due to human activities. The unusual rate and extent of anthropogenic alterations of the environment may exceed the capacity of developmental, genetic, and demographic mechanisms that populations have evolved to deal with environmental change. To begin to understand the limits to population persistence, we present a simple evolutionary model for the critical rate of environmental change beyond which a population must decline and go extinct. We use this model to highlight the major determinants of extinction risk in a changing environment, and identify research needs for improved predictions based on projected changes in environmental variables. Two key parameters relating the environment to population biology have not yet received sufficient attention. Phenotypic plasticity, the direct influence of environment on the development of individual phenotypes, is increasingly considered an important component of phenotypic change in the wild and should be incorporated in models of population persistence. Environmental sensitivity of selection, the change in the optimum phenotype with the environment, still crucially needs empirical assessment. We use environmental tolerance curves and other examples of ecological and evolutionary responses to climate change to illustrate how these mechanistic approaches can be developed for predictive purposes.

  3. Changing the diet of a nation: Population/regulatory strategies for a developed economy.

    Science.gov (United States)

    Nestle, M

    2000-09-01

    The principal nutritional problems of developed economies are related to the excessive and unbalanced intake of energy and nutrients. During the 20th century, as economies improved and food production became more efficient, conditions related to undernutrition were replaced by epidemics of coronary heart disease, certain cancers and other chronic conditions related to food overconsumption. In developed countries such as the United States, obesity became the predominant public health nutrition problem. To prevent obesity, people must consume less energy and be more active, but the food supplies of developed economies offer their populations amounts of energy that greatly exceed physiological need. Food overproduction causes competition in the food industry, limits its expansion, and leads food producers to invest heavily in marketing. To increase sales, food companies must encourage people to consume more of their products, substitute their products for others or develop new markets. Such efforts create an environment in which food is readily available at all times and readily overconsumed. Marketing expenditures for any single food product greatly exceed the total amounts available to governments for national campaigns to prevent chronic diseases. Existing government policies often support this environment through price supports and other means. To reverse obesity and its health consequences, governments need to consider ways to address the food environment through policies in education, agriculture, school meals, pricing, taxation and other means, as well as to develop mechanisms to fund new programme initiatives. PMID:24398276

  4. Climate change – health impacts due to changes in the indoor environment; research need

    OpenAIRE

    Crump, Derrick

    2012-01-01

    People in industrialised countries spend approximately 80% of their time indoors and the young and the elderly and people in poor health are likely to spend considerably more time indoors, particularly at home. Therefore all aspects of health that are related to environmental conditions can be impacted by the quality of the indoor environment. The indoor environment should provide shelter from the extremes of the outdoors and maintain a comfortable indoor climate, particular...

  5. Optimisation of product change process and demand-supply chain in high tech environment

    OpenAIRE

    D. Yang

    2011-01-01

    Abstract Information and communications technology (ICT) companies face challenges in an unpredictable business environment, where demand-supply forecasting is not accurate enough. How to optimally manage product change process and demand-supply chain in this type of environment? Companies face pressures to simultaneously be efficient, responsive and innovative, i.e. to minimise costs, and shorten order delivery and product change periods. This thesis included three action research c...

  6. RISK ENVIRONMENT AS SOCIAL REALITY CHANGE FACTOR: THE PROBLEM OF SOCIAL REGULATION

    OpenAIRE

    ZUBOK YU. A.; CHUPROV V.I.

    2015-01-01

    The article explains the theoretical concept of modern environment study transformation based on risk approach. The risks occurring in the environment are conceptualized as the environmental and the activity phenomenon appearing during the transition from certainty to uncertainty and vice versa. The dialectical relationship of uncertainty and non-linearity is argued in changing social reality of modern risk society. The problems of risk social regulation in a changing reality.Reflecting in th...

  7. Latest Achievements on Climate Change and Forest Interactions in a Polluted Environment

    OpenAIRE

    2014-01-01

    The COST Action FP0903 “Climate Change and Forest Mitigation and Adaptation in a Polluted Environment (MAFor)” involved 29 countries and created a platform for information exchange with experts from different fields, with the following main objectives: 1) to increase understanding of the state and potential of forest mitigation and adaptation to climate change in a polluted environment and 2) to reconcile process-oriented research, long-term monitoring and applied modelling at comprehensive f...

  8. Changes in built environment and in vernacular architecture through globalization: Case of Battalgazi inTurkiye

    OpenAIRE

    Yildirim, Mucahit; Korkmaz, Mahir

    2012-01-01

    Housing and its architectural characteristics physically change in step with changes in culture, social demographics, behavior and environmental structures. These physical changes influence the environment and housing because of contemporary life-styles and behaviors. The cultural identity which has been created in a long period of time is going to be lost rapidly. Cultural changes also include migration. The migration from rural areas to the downtowns causes variety in traditions and the arc...

  9. COST EFFECTIVE REGULATORY APPROACHES TO ENHANCE DOMESTIC OIL & GAS PRODUCTION AND ENSURE THE PROTECTION OF THE ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    Ben Grunewald; Paul Jehn; Tom Gillespie; Ben Binder

    2004-12-21

    The Environmental Information Management Suite/Risk Based Data Management System (EIMS/RBDMS) and Cost Effective Regulatory Approach (CERA) programs continue to be successful. All oil and gas state regulatory programs participate in these efforts. Significant accomplishments include: streamline regulatory approaches, enhancing environmental protection, and making oil and gas data available via the Internet. Oil and gas companies worldwide now have access to data on state web sites. This reduces the cost of exploration and enables companies to develop properties in areas that would have been cost prohibited for exploration. Early in project, GWPC and State Oil and Gas agencies developed the EIMS and CERA strategic plan to prioritize long term development and implementation. The planning process identifies electronic commerce and coal bed methane as high priorities. The group has involved strategic partners in industry and government to develop a common data exchange process. Technical assistance to Alaska continues to improve their program management capabilities. New initiatives in Alaska include the development of an electronic permit tracking system. This system allows managers to expedite the permitting process. Nationwide, the RBDMS system is largely completed with 22 states and one Indian Nation now using this nationally accepted data management system. Additional remaining tasks include routine maintenance and the installation of the program upon request for the remaining oil and gas states. The GWPC in working with the BLM and MMS to develop an XML schema to facilitate electronic permitting and reporting (Appendix A, B, and C). This is a significant effort and, in years to come, will increase access to federal lands by reducing regulatory barriers. The new initiatives are coal bed methane and e-commerce. The e-commerce program will provide industry and BLM/MMS access to the millions of data points housed in the RBDMS system. E-commerce will streamline

  10. Changes in phosphorylation pattern of regulatory proteins after X-irradiation of mouse embryos during 2-cell stage

    International Nuclear Information System (INIS)

    Phosphoproteins are the major key molecules responsible for the regulation of the complex network of cellular responses to external signals. Especially the signal transduction pathways and the control of the cell cycle are regulated by phosphorylated enzymes and substrate molecules. Studies have identified the phosphorylation of tyrosine residues to be one of the crucial mechanisms mediating the proliferation and differentiation of cells. The aim of our study was to analyze the patterns of phosphoproteins of murine preimplantation embryos after irradiation with various doses (3-6 Gy). We tried to find out if there are changes in phosphorylation patterns at the transition from the four-cell stage to the eight-cell stage which are a result of a dose dependent radiation effect. Investigations were made to prove which influence X-irradiation has on regulatory mechanisms during the third cell cycle. We tried to characterize proteins with an altered phosphorylation pattern to find out if these proteins could be regulatory elements involved in the cell cycle control. (author)

  11. Changes in Translational Efficiency is a Dominant Regulatory Mechanism in the Environmental Response of Bacteria

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Ronald C.; Webb-Robertson, Bobbie-Jo M.; Markillie, Lye Meng; Serres, Margrethe H.; Linggi, Bryan E.; Aldrich, Joshua T.; Hill, Eric A.; Romine, Margaret F.; Lipton, Mary S.; Wiley, H. S.

    2013-09-23

    To understand how cell physiological state affects mRNA translation, we used Shewanella oneidensis MR-1 grown under steady state conditions at either aerobic or suboxic conditions. Using a combination of quantitative proteomics and RNA-Seq, we generated high-confidence data on >1000 mRNA and protein pairs. By using a steady state model, we found that differences in protein-mRNA ratios were primarily caused by differences in the translational efficiency of specific genes. When oxygen levels were lowered, 28% of the proteins showed at least a 2-fold change in expression. Altered transcription levels appeared responsible for 26% of the protein changes, altered translational efficiency appeared responsible for 46% and a combination of both were responsible for the remaining 28%. Changes in translational efficiency were significantly correlated with the codon usage pattern of the genes and measurable tRNA pools changed in response to altered O2 levels. Our results suggest that changes in the translational efficiency of proteins, in part caused by altered tRNA pools, is a major determinant of regulated protein expression in bacteria.

  12. 78 FR 8640 - Self-Regulatory Organizations; BATS Exchange, Inc.; Order Approving Proposed Rule Change To...

    Science.gov (United States)

    2013-02-06

    .... 65619 (October 25, 2011), 76 FR 67238 (October 31, 2011) (order approving proposed rule change by BATS...\\ \\7\\ See Notice supra note 3, at 76 FR 75460. \\8\\ BATS Rule 11.23(a)(23) defines ``Volume Based Tie....\\23\\ \\22\\ See Notice supra note 3, at 77 FR at 75460. BATS Rule 11.23(a)(22) defines a RHO order as...

  13. Regulatory mechanism of radiation-induced cancer cell death by the change of cell cycle

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Soo Jin; Jeong, Min Ho; Jang, Ji Yeon [College of Medicine, Donga Univ., Pusan (Korea, Republic of)

    2003-09-01

    cycle regulatory activites. In this study, we present a unique and reproducible model in which for investigating the mechanisms of various, radiation-induced, cancer cell death patterns. Further evaluation by using this model will provide a potent target for a new strategy of radiotherapy.

  14. Environment

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2016-01-01

    The term environment refers to the internal and external context in which organizations operate. For some scholars, environment is defined as an arrangement of political, economic, social and cultural factors existing in a given context that have an impact on organizational processes and structures....... For others, environment is a generic term describing a large variety of stakeholders and how these interact and act upon organizations. Organizations and their environment are mutually interdependent and organizational communications are highly affected by the environment. This entry examines the...... origin and development of organization-environment interdependence, the nature of the concept of environment and its relevance for communication scholarships and activities....

  15. Plio-Pleistocene climate change and geographic heterogeneity in plant diversity-environment relationships

    DEFF Research Database (Denmark)

    Svenning, J.-C.; Normand, Signe; Skov, Flemming

    2009-01-01

    Plio-Pleistocene climate change may have induced geographic heterogeneity in plant species richness-environment relationships in Europe due to greater in situ species survival and speciation rates in southern Europe. We formulate distinct hypotheses on how Plio-Pleistocene climate change may have...... for the contrasting findings for the two richness-environment relationships. In conclusion, we find support for the idea that Plio-Pleistocene climate change may sometimes affect current species richness-environment relationships via its effects on regional species pools. However, further studies integrating...... analyses showed that plant species richness generally increased with topographic heterogeneity (ln-transformed altitudinal range) and actual evapotranspiration (AET). We also found evidence for strong geographic heterogeneity in the species richness-environment relationship, with a greater increase...

  16. Future monitoring and research needs for forest ecosystems in a changing environment: an introduction

    OpenAIRE

    Schaub M

    2009-01-01

    In order to identify future monitoring and research needs, a COST Strategic workshop on the role of "Forest ecosystems in a changing environment" assembled nearly 180 scientists from 30 countries in Istanbul on 11-13 March 2008. The workshop specifically tackled the fields of climate change and forests, ozone, atmospheric deposition and critical loads, biodiversity, as well as quality assurance in forest monitoring.

  17. Climate change impacts on wheat production in a Mediterranean environment in Western Australia

    NARCIS (Netherlands)

    Ludwig, F.; Asseng, S.

    2006-01-01

    The environment in which crops will be grown in the future will change. CO2 concentrations [CO2] and temperatures (T) will probably increase and a decline of winter rainfall is predicted for south-west Australia. To be able to adapt crop systems to a changing climate it is important to know how diff

  18. Learning Is Change: Creating an Environment for Sustainable Organizational Change in Continuing and Higher Education

    Science.gov (United States)

    Schultz, Christie

    2014-01-01

    This article explores the ways in which learning itself is a form of organizational change and, as such, supports organizational readiness for change. The study considers a continuing education unit within a major Canadian university that managed to transform its decentralized and independent student records and administration system (student…

  19. Change: Threat or opportunity for human progress? V. 5. Ecological change: Environment, development and poverty linkages

    International Nuclear Information System (INIS)

    This volume consists of 18 articles that examine the changing ecological balance of the world and its effect on human prosperity. The problems caused by global warning, climate change and environmental degradation will have serious effects in both the short and the long term. Two of the 18 articles fall within INIS scope: these have been indexed separately. Tabs

  20. Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements

    OpenAIRE

    Dhiman, Vineet K; Attwood, Kristopher; Campbell, Moray J.; Smiraglia, Dominic J

    2015-01-01

    DNA methylation is an epigenetic modification that contributes to stable gene silencing by interfering with the ability of transcriptional regulators to bind to DNA. Recent findings have revealed that hormone stimulation of certain nuclear receptors induces rapid, dynamic changes in DNA methylation patterns alongside transcriptional responses at a subset of target loci, over time. However, the ability of androgen receptor (AR) to dynamically regulate gene transcription is relatively under-stu...

  1. Dynamics of evolutionary rescue in changing environments and the emergence of antibiotic resistance.

    Science.gov (United States)

    Wu, Yue; Saddler, Clare A; Valckenborgh, Frank; Tanaka, Mark M

    2014-01-01

    Populations can go extinct when their environments deteriorate, but evolutionary rescue occurs when a shrinking population adapts to the new environmental conditions. The emergence of resistance from a drug sensitive bacterial population under treatment can be regarded as an instance of evolutionary rescue. Understanding evolutionary rescue in a particular context such as drug resistance requires knowledge of how the environment changes and how selection coefficients change as a result. In this study, we propose a model for evolutionary rescue under three different scenarios of environmental change: abrupt change, periodic fluctuation and gradual decay. The model makes use of the notion of reaction norms to describe fitness values that depend on both genotype and environmental state. We find that although drug sensitive bacterial populations may be large, allowing them to generate resistant mutants frequently, a harsh abrupt change due to the drug usually drives them extinct. Evolutionary rescue occurs far more frequently under the milder forms of environmental change we investigated. Rescue is favoured when the absolute fitnesses of individuals remain sufficiently high over the range of environment qualities experienced by the population. The minimum environment quality, which is inversely related to drug dose in the antibiotic context, is thus an important factor. Interestingly, in the periodic fluctuation model, the inter-dose period is less influential in promoting rescue through resistance unless the minimum environment quality is in a particular range. We also investigated fitness trade-offs across environments including the case of a resistant allele not subject to any trade-off (a "superbug"). This fitness trade-off affects the probability of rescue in decaying environments, but surprisingly has only a weak effect in the periodic fluctuation scenario. Finally, we use the model to show how niche construction, whereby organisms are the source of environmental

  2. Vulnerability of the Barents Sea environment to climate changes: a review of the current assessments

    Energy Technology Data Exchange (ETDEWEB)

    Gelfan, A.; Danilov-Danilyan, V.

    2009-07-15

    Authors' conclusion: Climate change is not considered to be just 'one more stress' on the ecosystem, but rather it will create complex and dynamic changes in the environment that may alter the level of its vulnerability. Cumulative effects can be defined as changes to the environment that are caused by an action in combination with other past, present and future human actions (Environment Canada 2003). The magnitude and effects of multiple stresses can be equal to the sum of the individual effects (additive effects) or they may strengthen or weaken each other (positive or negative feedbacks). To understand complex interactions within the system atmosphere-land surface-ocean at regional scales and to assess influence of the environmental changes on the ecological conditions, sophisticated models should be developed allowing to account for regional peculiarities of these systems. Development of such models is considered as one of the main challenge of the Earth system science. (author)

  3. New Change Detection Techniques to monitor land cover dynamics in mine environment

    Science.gov (United States)

    Pathak, S.

    2014-11-01

    Land use and land cover are dynamic and is an important component in understanding the interactions of the human activities with the environment and thus it is necessary to simulate environmental changes. Land use/cover (LU/LC) change detection is very essential for better understanding of landuse dynamic during a known period of time for sustainable management. Mining is one of the most dynamic processes with direct as well as indirect impact on the environment. Hence, mine area provides ideal situation for evaluating the chronological changes in land-use patterns. Digital change detection of satellite data at different time interval helps in analyzing the changes in the spatial extent of mine along with the associated activities. In present study, various algorithms Iteratively Re-weighted Multivariate Alteration Detection (MAD) on raw data where class wise comparison becomes a difficult proposition and object based segmentation and change detection as post classification comparison were assessed.

  4. Learning and assessment credibility: The design of examination strategies in a changing learning environment

    OpenAIRE

    Michael Diprose

    2013-01-01

    Learning environments for higher education have changed considerably in the last 20 years, especially since the advent of the internet. In addition to the change in learning technologies has come an increasing politicisation of higher education and in the UK a change from being virtually free in the 1980s to one where annual costs (Sheffield Press Release, 2012) can now be in excess of £9000 p.a. Since there are various routes to attaining higher education and commercialisation and competitio...

  5. Climate Change and Our Environment: The Effect on Respiratory and Allergic Disease

    OpenAIRE

    Barnes, Charles S.; Alexis, Neil E; Bernstein, Jonathan A.; John R. Cohn; Demain, Jeffrey G.; Horner, Elliott; Levetin, Estelle; Nel, Andre; Phipatanakul, Wanda

    2013-01-01

    Climate change is a constant and ongoing process. It is postulated that human activities have reached a point at which we are producing global climate change. This article provides suggestions to help the allergist/environmental physician integrate recommendations about improvements in outdoor and indoor air quality and the likely response to predicted alterations in the earth’s environment into their patient’s treatment plan. Many changes that affect respiratory disease are anticipated. Exam...

  6. Complexity in Organizations and Environment - Adaptive Changes and Adaptive Decision-Making

    OpenAIRE

    Robert Fabac

    2010-01-01

    The features of complexity are ever more present in modern organizations and in environments in which they operate, trying to survive and be as competitive as possible.) In the processes of, the so-called emergence, the formal organizational structure, designed purposefully and with a plan, is going through a change due to complexity and the need for adaptation. As a result, there is a variety of new informal groups. At the same time, the intended structural changes and business process chang...

  7. Confronting Regulatory Cost and Quality Expectations. An Exploration of Technical Change in Minimum Efficiency Performance Standards

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Margaret [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Stanford Univ., CA (United States); Spurlock, C. Anna [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yang, Hung-Chia [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-09-21

    The dual purpose of this project was to contribute to basic knowledge about the interaction between regulation and innovation and to inform the cost and benefit expectations related to technical change which are embedded in the rulemaking process of an important area of national regulation. The area of regulation focused on here is minimum efficiency performance standards (MEPS) for appliances and other energy-using products. Relevant both to U.S. climate policy and energy policy for buildings, MEPS remove certain product models from the market that do not meet specified efficiency thresholds.

  8. Regulatory Changes of N-Acetylgalactosamine Terminal Sugar in Early Mouse Embryonic Paraxial Mesenchyme

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Miri

    2012-01-01

    Full Text Available Objective: The development of vertebrae is a complex phenomenon that is correlated with distinct morphological and biochemical alterations in the paraxial mesenchyme and glycoconjugates. The purpose of this study is to investigate the glycosylation pattern in paraxial mesenchyme-forming vertebrae by using the lectin histochemical technique.Materials and Methods: In this descriptive-analytic study, B4G fixed paraffin sections of 9 to 15 day Balb/c mouse embryos were processed for histochemical studies using seven different HRP-labelled lectins: Glycin max (SBA, Maclura pomifera (MPA, Wistaria floribunda (WFA, Vicia villosa (VVA which all of them are specific for N-acetylgalactosamine (GalNAc, Ulex europius (UEA1, binds to α-L-fucose, wheat germ agglutinin (WGA, binds to sialic acid, and Griffonia simplicifolia (GSA1-B4, binds to galactose terminal sugars. The sections were observed separately by three examiners who were blinded to the lectins. Grading was done according to the intensity of the tested lectins’ reactions with the specimen, from negative (- to severe (+++. Data was analysed with SPSS software (version 11.5 and the non-parametric Kruskal Wallis test; p<0.05 was considered significant.Results: Our findings showed that among the tested lectins, only GalNAc residue sensitive lectins showed regulated changes in paraxial mesenchyme. Reactions of WFA and MPA lectins with paraxial mesenchyme were severe on GD9. Reactions of WFA continued to GD15 constantly, while MPA reactions continued strongly to GD12, significantly decreased thereafter (p<0.001, and then disappeared. VVA and SBA bindings initiated weakly on GD10 and continued to GD12 without changing. These reactions increased significantly (p<0.001 thereafter, became severe to GD14, and later disappeared. The other tested lectins did not reveal regulated changes.Conclusion: According to these findings it can be concluded that only the GalNAc terminal sugar showed temporally regulated

  9. A systematic policy approach to changing the food system and physical activity environments to prevent obesity.

    Science.gov (United States)

    Sacks, Gary; Swinburn, Boyd A; Lawrence, Mark A

    2008-01-01

    As obesity prevention becomes an increasing health priority in many countries, including Australia and New Zealand, the challenge that governments are now facing is how to adopt a systematic policy approach to increase healthy eating and regular physical activity. This article sets out a structure for systematically identifying areas for obesity prevention policy action across the food system and full range of physical activity environments. Areas amenable to policy intervention can be systematically identified by considering policy opportunities for each level of governance (local, state, national, international and organisational) in each sector of the food system (primary production, food processing, distribution, marketing, retail, catering and food service) and each sector that influences physical activity environments (infrastructure and planning, education, employment, transport, sport and recreation). Analysis grids are used to illustrate, in a structured fashion, the broad array of areas amenable to legal and regulatory intervention across all levels of governance and all relevant sectors. In the Australian context, potential regulatory policy intervention areas are widespread throughout the food system, e.g., land-use zoning (primary production within local government), food safety (food processing within state government), food labelling (retail within national government). Policy areas for influencing physical activity are predominantly local and state government responsibilities including, for example, walking and cycling environments (infrastructure and planning sector) and physical activity education in schools (education sector). The analysis structure presented in this article provides a tool to systematically identify policy gaps, barriers and opportunities for obesity prevention, as part of the process of developing and implementing a comprehensive obesity prevention strategy. It also serves to highlight the need for a coordinated approach to

  10. Dynamic changes of the Th17/Tc17 and regulatory T cell populations interfere in the experimental autoimmune diabetes pathogenesis.

    Science.gov (United States)

    Yaochite, Juliana Navarro Ueda; Caliari-Oliveira, Carolina; Davanso, Mariana Rodrigues; Carlos, Daniela; Malmegrim, Kelen Cristina Ribeiro; Cardoso, Cristina Ribeiro de Barros; Ramalho, Leandra Naira Zambelli; Palma, Patricia Vianna Bonini; da Silva, João Santana; Cunha, Fernando Queiróz; Covas, Dimas Tadeu; Voltarelli, Júlio César

    2013-03-01

    A balance between proinflammatory (Th17 and Tc17) and anti-inflammatory (regulatory T cells) subsets of T cells is essential to maintain immunological tolerance and prevent the onset of several autoimmune diseases, including type 1 diabetes. However, the kinetics of these subsets and disease severity during the streptozotocin (STZ)-induced diabetes course has not been determined. Thus, susceptible C57BL/6 mice were administrated with multiple low doses of STZ and we evaluated the frequency/absolute number of these T cell subsets in the pancreatic lymph nodes (PLNs) and spleen and Th1, Th17, Treg cytokine production in the pancreatic tissue. At different time points of the disease progression (6, 11, 18 and 25 days after the last STZ administration), the histopathological alterations were also evaluated by H&E and immunohistochemistry staining. During the initial phase of diabetes development (day 6), we noted increased numbers of CD4(+) and CD8(+) T cells in spleen and PLNs. At the same time, the frequencies of Th17 and Tc17 cells in PLNs were also enhanced. In addition, the early augment of interferon gamma (IFN-γ), tumoral necrosis factor (TNF-α), IL-6 and IL-17 levels in pancreatic tissue correlated with pancreatic islet inflammation and mild β-cell damage. Notably, the absolute number of Treg cells increased in PLNs during over time when compared to control group. Interestingly, increased IL-10 levels were associated with control of the inflammatory process during the late phase of the type 1 diabetes (day 25). In agreement, mice lacking the expression of IL-17 receptor (Il17r) showed impairment in STZ-induced diabetes progression, reduced peri-insulitis and beta cells preservation when compared with wild-type mice. Our findings suggest that dynamic changes of pathogenic Th17/Tc17 and regulatory T cell subsets numbers is associated with early strong inflammation in the pancreatic islets followed by late regulatory profile during the experimental STZ

  11. Impact of recent DOT regulatory changes (HM-169A) on D ampersand D packaging and transportation

    International Nuclear Information System (INIS)

    On Thursday, September 28, 1995, the U.S. Department of Transportation (DOT) issued docket HM-169A, open-quotes Hazardous Materials Transportation Regulations; Compatibility with Regulations of the International Atomic Energy Agency.close quotes In the words of the DOT, open-quotes This final rule amends the Hazardous Materials Regulations pertaining to the transportation of radioactive materials to harmonize them with those of the International Atomic Energy Agency (IAEA) and, thus most of the nuclear nations of the world.close quotes This docket introduces several significant changes that will dramatically affect the packaging and transport of radioactive materials, especially the categories of waste/materials generated as a result of the extensive decontamination and decommissioning (D ampersand D) programs under way throughout the U.S. Department of Energy and the nuclear industry as a whole, and the upcoming decommissioning of the nuclear power plants

  12. Market redesign and regulatory change : how companies doing business in Alberta's power markets will be affected

    International Nuclear Information System (INIS)

    The Power Pool of Alberta (PPA) began its operations in 1996 based on a model with a single price set based on day ahead offers/bids and real time dispatch. The Electric Utilities Act was amended in 1998 and direct sales were permitted in 1999. The Power Purchase Arrangement Auction was implemented in 2000. Significant events took place in 2001, including: (1) retail competition, (2) PPAs began operations, (3) restrictions on direct sales were removed, (4) forward exchange operation, and (5) ancillary services market. In 2002, the Market Achievement Plan II was implemented and government industry structure was reviewed. There are several considerations regarding market redesign, such as day ahead market, capacity market, congestion management, and Northwest Regional Transmission Organization (RTO West). The role of the International Standard Organization (ISO) was discussed, with reference to the Independent System Operator, Independent Market Operator, and Transmission and Market Planner. Redesign must involve all participants and include informed, phased in changes

  13. Climate Change and China as a Global Emerging Regulatory Sea Power in the Arctic Ocean: Is China a Threat for Arctic Ocean Security?

    OpenAIRE

    Cassotta, Sandra; Hossain, Kamrul; Ren, Jingzheng; Goodsite, Michael Evan

    2015-01-01

    The impact of climate change in the Arctic Ocean such as ice melting and ice retreat facilitatesnatural resources extraction. Arctic fossil fuel becomes the drivers of geopolitical changes in theArctic Ocean. Climate change facilitates natural resource extractions and increases competitionbetween states and can result in tensions, even military ones. This article investigates through apolitical and legal analysis the role of China as an emerging regulatory sea power in the ArcticOcean given i...

  14. Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice.

    Science.gov (United States)

    An, Jee Hyun; Ohn, Jung Hun; Song, Jung Ah; Yang, Jae-Yeon; Park, Hyojung; Choi, Hyung Jin; Kim, Sang Wan; Kim, Seong Yeon; Park, Woog-Yang; Shin, Chan Soo

    2014-03-01

    Growing evidence shows the possibility of a role of microRNAs (miRNA) in regulating bone mass. We investigated the change of miRNAs and mRNA expression profiles in bone tissue in an ovariectomized mice model and evaluated the regulatory mechanism of bone mass mediated by miRNAs in an estrogen-deficiency state. Eight-week-old female C3H/HeJ mice underwent ovariectomy (OVX) or sham operation (Sham-op), and their femur and tibia were harvested to extract total bone RNAs after 4 weeks for microarray analysis. Eight miRNAs (miR-127, -133a, -133a*, -133b, -136, -206, -378, -378*) were identified to be upregulated after OVX, whereas one miRNA (miR-204) was downregulated. Concomitant analysis of mRNA microarray revealed that 658 genes were differentially expressed between OVX and Sham-op mice. Target prediction of differentially expressed miRNAs identified potential targets, and integrative analysis using the mRNA microarray results showed that PPARγ and CREB pathways are activated in skeletal tissues after ovariectomy. Among the potential candidates of miRNA, we further studied the role of miR-127 in vitro, which exhibited the greatest changes after OVX. We also studied the effects of miR-136, which has not been studied in the context of bone mass regulation. Transfection of miR-127 inhibitor has enhanced osteoblastic differentiation in UAMS-32 cells as measured by alkaline phosphatase activities and mRNA expression of osteoblast-specific genes, whereas miR-136 precursor has inhibited osteoblastic differentiation. Furthermore, transfection of both miR-127 and miR-136 inhibitors enhanced the osteocyte-like morphological changes and survival in MLO-Y4 cells, whereas precursors of miR-127 and -136 have aggravated dexamethasone-induced cell death. Both of the precursors enhanced osteoclastic differentiation in bone marrow macrophages, indicating that both miR-127 and -136 are negatively regulating bone mass. Taken together, these results suggest a novel insight into the

  15. Adaptive management of irrigated rice in the changing environments of the Sahel

    OpenAIRE

    De, Vries

    2011-01-01

    Key words: Alternate wetting and drying, Climate change adaptation, Crop growth simulation models, Genotype × environment interaction, N use efficiency,  Oryza sativa L., Phenology, Sahelian irrigation schemes, Sowing date, Spikelet sterility, Temperature increase, Water productivity, Weed control. In the vulnerable environment of the Sahel with its erratic rainfall pattern, irrigated rice production is of major importance. To aid Sahelian rice farmers to sustain irrigated rice pro...

  16. The future of marketing: an appropriate response to the environment changes

    OpenAIRE

    Victor DANCIU

    2013-01-01

    The future landscape of the business worldwide will have the marketing evolutions as a driver. These evolutions will be the response to the changes of business and marketing environment. The paper aims to analyze both the key trends that are shaping the macro environment, markets and consumers and their impact on the marketing at business level. First, these issues are presented as they result of both theoretical and applied various researches performed by numerous international and national ...

  17. Molecular dynamics simulations of conformation changes of HIV-1 regulatory protein on graphene

    Science.gov (United States)

    Zhao, Daohui; Li, Libo; He, Daohang; Zhou, Jian

    2016-07-01

    The fragment of viral protein R (Vpr), Vpr13-33, plays an important role in regulating nuclear importing of HIV genes through channel formation in which it adopts a leucine-zipper-like alpha-helical conformation. A recent experimental study reported that helical Vpr13-33 would transform to β-sheet or random coil structures and aggregate on the surface of graphene or graphene oxide through hydrophobic interactions. Due to experimental limitations, however, there is still a considerable lack of understanding on the adsorption dynamics at the early stage of the conformational transition at water-graphene interface and the underlying driving force at molecular level. In this study, atomistic molecular dynamics simulations were used to explore the conformation transition phenomena. Vpr13-33 kept α-helical structure in solution, but changed to β-sheet structure when strongly adsorbed onto graphene. Preferential adsorption of Vpr13-33 on graphene is dominated by hydrophobic interactions. The cluster analysis identified the most significant populated conformation and the early stage of structure conversion from α-helical to β-sheet was found, but the full β-sheet propagation was not observed. Free energy landscape analysis further complemented the transformation analysis of peptide conformations. These findings are consistent with experimental results, and give a molecular level interpretation for the reduced cytotoxicity of Vpr13-33 to some extent upon graphene exposure. Meanwhile, this study provides some significant insights into the detailed mechanism of graphene-induced protein conformation transition.

  18. Latest Achievements on Climate Change and Forest Interactions in a Polluted Environment

    DEFF Research Database (Denmark)

    Carriero, Giulia; Tuovinen, Juha-Pekka; Clarke, Nicholas;

    2014-01-01

    The COST Action FP0903 “Climate Change and Forest Mitigation and Adaptation in a Polluted Environment (MAFor)” involved 29 countries and created a platform for information exchange with experts from different fields, with the following main objectives: 1) to increase understanding of the state...... and potential of forest mitigation and adaptation to climate change in a polluted environment and 2) to reconcile process-oriented research, long-term monitoring and applied modelling at comprehensive forest research sites. In particular, MAFor translated the existing European knowledge on climate and air...... the information from European forest research/monitoring networks; the development of a new concept of forest sites for research and monitoring (Supersites); the identification of the main knowledge gaps; and the definition of priorities for forest adaptation to climate change in a polluted environment...

  19. Effects of Self-Regulatory Status and Practice Type on Student Performance in the Mobile Learning Environment

    Science.gov (United States)

    Tutty, Jeremy Ian

    2013-01-01

    The next generation of computer-based learning environments has arrived. This generation of technology is characterized by mobile and portable devices such as smartphones and tablet computers with wireless broadband access. With these devices comes the promise of extending the online learning revolution. The purpose of this study was to…

  20. Complex Genotype by Environment interactions and changing genetic architectures across thermal environments in the Australian field cricket, Teleogryllus oceanicus

    Directory of Open Access Journals (Sweden)

    Dowling Damian K

    2011-07-01

    Full Text Available Abstract Background Biologists studying adaptation under sexual selection have spent considerable effort assessing the relative importance of two groups of models, which hinge on the idea that females gain indirect benefits via mate discrimination. These are the good genes and genetic compatibility models. Quantitative genetic studies have advanced our understanding of these models by enabling assessment of whether the genetic architectures underlying focal phenotypes are congruent with either model. In this context, good genes models require underlying additive genetic variance, while compatibility models require non-additive variance. Currently, we know very little about how the expression of genotypes comprised of distinct parental haplotypes, or how levels and types of genetic variance underlying key phenotypes, change across environments. Such knowledge is important, however, because genotype-environment interactions can have major implications on the potential for evolutionary responses to selection. Results We used a full diallel breeding design to screen for complex genotype-environment interactions, and genetic architectures underlying key morphological traits, across two thermal environments (the lab standard 27°C, and the cooler 23°C in the Australian field cricket, Teleogryllus oceanicus. In males, complex three-way interactions between sire and dam parental haplotypes and the rearing environment accounted for up to 23 per cent of the scaled phenotypic variance in the traits we measured (body mass, pronotum width and testes mass, and each trait harboured significant additive genetic variance in the standard temperature (27°C only. In females, these three-way interactions were less important, with interactions between the paternal haplotype and rearing environment accounting for about ten per cent of the phenotypic variance (in body mass, pronotum width and ovary mass. Of the female traits measured, only ovary mass for crickets

  1. Total Environment of Change: Impacts of Climate Change and Social Transitions on Subsistence Fisheries in Northwest Alaska

    Directory of Open Access Journals (Sweden)

    Courtney Carothers

    2012-03-01

    Full Text Available Arctic ecosystems are undergoing rapid changes as a result of global climate change, with significant implications for the livelihoods of Arctic peoples. In this paper, based on ethnographic research conducted with the Iñupiaq communities of Noatak and Selawik in northwestern Alaska, we detail prominent environmental changes observed over the past twenty to thirty years and their impacts on subsistence-based lifestyles. However, we suggest that it is ultimately insufficient to try to understand how Arctic communities are experiencing and responding to climate change in isolation from other stressors. During interviews and participant observation documenting local observations of climatic and related environmental shifts and impacts to subsistence fishing practices, we find the inseparability of environmental, social, economic, cultural, and political realms for community residents. Many of our informants, who live in a mixed economy based on various forms of income and widespread subsistence harvesting of fish and game, perceive and experience climate change as embedded among numerous other factors affecting subsistence patterns and practices. Changing lifestyles, decreasing interest by younger generations in pursuing subsistence livelihoods, and economic challenges are greatly affecting contemporary subsistence patterns and practices in rural Alaska. Observations of climate change are perceived, experienced, and articulated to researchers through a broader lens of these linked lifestyle and cultural shifts. Therefore, we argue that to properly assess and understand the impacts of climate change on the subsistence practices in Arctic communities, we must also consider the total environment of change that is dramatically shaping the relationship between people, communities, and their surrounding environments.

  2. The Role of Aerosol in Climate Change,the Environment,and Human Health

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Aerosol is an important component of the atmosphere,and its source,composition,distribution,and effects are highly complicated.Governments and scientists have given much attention to aerosol problems,and it has become a hot topic due to the important role it plays in climate change and the Earth's environment.In this paper,1) the importance of aerosol in climate change,the atmospheric environment,and human health is summarized;2) the recent serious problems of aerosol pollution and the shortage of current aerosol research in China are pointed out;and 3) the necessity to enhance aerosol research in China is emphasized.

  3. Description of Multimedia Environment Pollutant Assessment System (MEPAS) version 3.2 modification for the Nuclear Regulatory Commission

    International Nuclear Information System (INIS)

    The Multimedia Environmental Pollutant Assessment System (MEPAS) is a software tool developed by Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy (DOE) to allow DOE to conduct human health risk analyses nation-wide. This report describes modifications to the MEPAS to meet the requirements of the U.S. Nuclear Regulatory Commission (NRC) staff in their analyses of Site Decommissioning Management Plan sites. In general, these modifications provide the MEPAS, Version 3.2, with the capability of calculating and reporting annual dose/risk information. Modifications were made to the exposure pathway and health impact modules and the water and atmospheric transport modules. Several example cases used to test the MEPAS, Version 3.2, are also presented. The MEPAS, Version 3.2, also contains a new source-term release component that includes models for estimating contaminant loss from three different types of source zones (contaminated aquifer, contaminated pond/surface impoundment, and contaminated vadose zone) due to decay/degradation, leaching, wind suspension, water erosion, overland flow, and/or volatilization. When multiple loss routes are assumed to occur simultaneously, the models account for their interaction and calculate an appropriate pollutant mass budget to each loss route over time

  4. ARPANSA's regulatory role in the protection of the environment from ionising radiation. Licensing the remediation of abandoned uranium mine workings in Kakadu National Park

    International Nuclear Information System (INIS)

    ARPANSA was established by the Australian Radiation Protection and Nuclear Safety Act 1998 to perform a number of specific functions including the licensing of those activities involving radioactive material that are undertaken by Commonwealth entities. This paper describes the role of the regulator in the rehabilitation of an area of Kakadu National Park, which has been licensed as a Prescribed Radiation Facility. When making a decision on whether to issue a licence, the CEO of ARPANSA is obliged by the ARPANS Act to consider, inter alia, whether it has been established that the proposed conduct can be carried on without undue risk to the health and safety of people, and to the environment. However, when licensing the remediation of environmental and radiological consequences of mining activities special difficulties may arise in determining the regulatory approach to be adopted with regard to an intervention of this nature. One specific example is the limited internationally accepted objective radiological criteria on which to base regulation of any remediation. In the particular case of an intervention in Kakadu National Park, the multiplicity of interest groups directly or indirectly involved in management of the affairs of this world heritage listed area adds an extra element to the regulatory equation. (author)

  5. Future monitoring and research needs for forest ecosystems in a changing environment: an introduction

    Directory of Open Access Journals (Sweden)

    Schaub M

    2009-01-01

    Full Text Available In order to identify future monitoring and research needs, a COST Strategic workshop on the role of "Forest ecosystems in a changing environment" assembled nearly 180 scientists from 30 countries in Istanbul on 11-13 March 2008. The workshop specifically tackled the fields of climate change and forests, ozone, atmospheric deposition and critical loads, biodiversity, as well as quality assurance in forest monitoring.

  6. Foreign direct investment in a changing political environment : Finnish investment decisions in South Korea

    OpenAIRE

    Korhonen, Kristiina

    2005-01-01

    This dissertation contributes to an understanding of foreign direct investment (FDI) in a changing political environment. The theoretical framework of the study is positioned to the geography of enterprise approach, but it has been contributed with theories from the fields of strategic management, international business, and political economy. The research problem of the study asks how transnational corporations (TNCs) perceive and react to the change in the host country’s political environme...

  7. Changing the learning environment to promote deep learning approaches in first year accounting students

    OpenAIRE

    Hall, Matthew; Ramsay, Alan; Raven, John

    2004-01-01

    Developing deep approaches to learning is claimed to enhance students' engagement with their subject material and result in improved analytical and conceptual thinking skills. Numerous calls have been made for accounting educators to adopt strategies that produce such results. This paper reports on changes to the learning environment centring on the introduction of group learning activities that were designed to improve the quality of students' learning outcomes. The impact of changes in the ...

  8. Footprints of air pollution and changing environment on the sustainability of built infrastructure

    OpenAIRE

    Kumar, P.; Imam, B

    2013-01-01

    Abstract Over 150 research articles relating three multi-disciplinary topics (air pollution, climate change and civil engineering structures) are reviewed to examine the footprints of air pollution and changing environment on the sustainability of building and transport structures (referred as built infrastructure). The aim of this review is to synthesize the existing knowledge on this topic, highlight recent advances in our understanding and discuss research priorities. The article begins wi...

  9. Deregulation of the Swedish Audit Industry and Changes in the Competitive Environment : Conflict, Imitation, and Innovativeness

    OpenAIRE

    Sebhatu, Abiel

    2011-01-01

    This thesis investigates the deregulation of the audit industry in Sweden, the changing competitive environment and innovativeness, a research gap that has not yet been bridged. This paper raises the question of how the innovativeness of firms within the audit industry have changed after deregulation. The ambition of this research is to have both theoretical and practical knowledge contribution. The theoretical framework constructed for this research is rooted in the literature review of thre...

  10. RECOMMENDATIONS FOR THE DISTRIBUTION STRATEGY IN CHANGING MARKET ENVIRONMENT : Case: Belgian Brewery Van Honsebrouck in Russia

    OpenAIRE

    Louckx, Yulia

    2014-01-01

    The efficient distribution strategy formulation becomes vital to the success and survival of any organization, especially when it is involved in international trade. Today’s world is particularly challenging due to rapidly changing market conditions. Therefore, in order to able to compete, satisfy customers, and meet the needs of other stakeholders profitably, it is crucial for any company to make profound market environment analyses, react to changes in the market and adjust strategies accor...

  11. Regulatory conformational changes of the ɛ subunit in single FRET-labeled F0F1-ATP synthase

    Science.gov (United States)

    Duncan, Thomas M.; Düser, Monika G.; Heitkamp, Thomas; McMillan, Duncan G. G.; Börsch, Michael

    2014-02-01

    Subunit ɛ is an intrinsic regulator of the bacterial FoF1-ATP synthase, the ubiquitous membrane-embedded enzyme that utilizes a proton motive force in most organisms to synthesize adenosine triphosphate (ATP). The C-terminal domain of ɛ can extend into the central cavity formed by the α and β subunits, as revealed by the recent X-ray structure of the F1 portion of the Escherichia coli enzyme. This insertion blocks the rotation of the central γ subunit and, thereby, prevents wasteful ATP hydrolysis. Here we aim to develop an experimental system that can reveal conditions under which ɛ inhibits the holoenzyme FoF1-ATP synthase in vitro. Labeling the C-terminal domain of ɛ and the γ subunit specifically with two different fluorophores for single-molecule Förster resonance energy transfer (smFRET) allowed monitoring of the conformation of ɛ in the reconstituted enzyme in real time. New mutants were made for future three-color smFRET experiments to unravel the details of regulatory conformational changes in ɛ.

  12. Generic framework for meso-scale assessment of climate change hazards in coastal environments

    DEFF Research Database (Denmark)

    Appelquist, Lars Rosendahl

    2013-01-01

    This paper presents a generic framework for assessing inherent climate change hazards in coastal environments through a combined coastal classification and hazard evaluation system. The framework is developed to be used at scales relevant for regional and national planning and aims to cover all...... coastal environments worldwide through a specially designed coastal classification system containing 113 generic coastal types. The framework provides information on the degree to which key climate change hazards are inherent in a particular coastal environment, and covers the hazards of ecosystem...... computing requirements, allowing for application in developing country settings. It is presented as a graphical tool—the Coastal Hazard Wheel—to ease its application for planning purposes....

  13. Effects of Conceptual Change Text Based Instruction on Ecology, Attitudes toward Biology and Environment

    Science.gov (United States)

    Çetin, Gülcan; Ertepinar, Hamide; Geban, Ömer

    2015-01-01

    The purpose of this study is to investigate the effects of the conceptual change text based instruction on ninth grade students' understanding of ecological concepts, and attitudes toward biology and environment. Participants were 82 ninth grade students in a public high school in the Northwestern Turkey. A treatment was employed over a…

  14. Nursing Workload and the Changing Health Care Environment: A Review of the Literature

    Science.gov (United States)

    Neill, Denise

    2011-01-01

    Changes in the health care environment have impacted nursing workload, quality of care, and patient safety. Traditional nursing workload measures do not guarantee efficiency, nor do they adequately capture the complexity of nursing workload. Review of the literature indicates nurses perceive the quality of their work has diminished. Research has…

  15. The path: sustainable development in conjunction with meeting the demands of a changing environment.

    OpenAIRE

    Jaular, Irene; Murua, Yolanda

    2014-01-01

    In the context of severe economic recession, the Library is compelled to adapt to this changing environment, in order to meet the requirements and demands of users with very specific needs. Taking the pillars of sustainable development as a reference point, and extrapolating them to our domain, we establish the next main goals

  16. Environment for Innovation: Exploring Associations with Individual Disposition toward Change, Organizational Conflict, Justice and Trust

    Science.gov (United States)

    Weinert, Daniel James

    2013-01-01

    The environment in higher education and healthcare is rapidly changing. Adaptation through innovation is critical for organizations responsible for the education of healthcare providers. This study examined the climate for innovation at chiropractic colleges and health sciences universities offering a doctor of chiropractic program. The…

  17. Climate Change Education: Quantitatively Assessing the Impact of a Botanical Garden as an Informal Learning Environment

    Science.gov (United States)

    Sellmann, Daniela; Bogner, Franz X.

    2013-01-01

    Although informal learning environments have been studied extensively, ours is one of the first studies to quantitatively assess the impact of learning in botanical gardens on students' cognitive achievement. We observed a group of 10th graders participating in a one-day educational intervention on climate change implemented in a botanical…

  18. Effect of Air Velocity on Thermal Comfort under Thermal Environment Ramp Changing

    Institute of Scientific and Technical Information of China (English)

    嵇赟喆; 涂光备; 孙琳

    2004-01-01

    Set points of the indoor air temperature and relative humidity in short-term staying location were studied. In this condition, the thermal reaction of human body varied with the ramp changes of the environmental thermal parameters.The change rules of about 60 subjects'thermal reaction to the ramp change of environment were surveyed, and the effect of air movement on the thermal reaction during transient condition was considered by using a questionnaire. With the experimental results and research findings under stable condition, a way to set environmental parameters of short-time staying location was recommended.

  19. THE IMPORTANCE OF MANAGEMENT AND LEADERSHIP IN A CHANGING BUSINESS ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Roxana Mironescu

    2014-01-01

    Full Text Available Change is a factor of impact on managerial functions especially upon those related to the coordination and training of the human resources. Change management is a broad spectrum of means, referring to different types of change , however, it is generally used in the processing management and in the strategic management, in the information management , including the electronic one. The analysis of changes inside the organization is very important , these changes allow the organizations to be more adaptable and innovative. However, some changes may suddenly occur and will independently act of the managers’will. If we are talking about the human change, then we should mention that the importance of this dimension of the organizational change is essential. The way people relate to change can be affected by the position they occupy inside the organization and the attitudes they adopt facing the change influence the role that they assume with the greatest ease in the change processes. Leadership and the organizational culture are in a tight relationship. Manager evaluates its business, in addition to a number of work processes and products, and the cultural environment too, so conducive, in his view, that it should activate and record the organizational and work performance.

  20. Agreement Maintenance Based on Schema and Ontology Change in P2P Environment

    CERN Document Server

    Banowosari, L Y; Mutiara, A B

    2010-01-01

    This paper is concern about developing a semantic agreement maintenance method based on semantic distance by calculating the change of local schema or ontology. This approach is important in dynamic and autonomous environment, in which the current approach assumed that agreement or mapping in static environment. The contribution of this research is to develop a framework based on semantic agreement maintenance approach for P2P environment. This framework based on two level hybrid P2P model architecture, which consist of two peer type: (1) super peer that use to register and manage the other peers, and (2) simple peer, as a simple peer, it exports and shares its contents with others. This research develop a model to maintain the semantic agreement in P2P environment, so the current approach which does not have the mechanism to know the change, since it assumed that ontology and local schema are in the static condition, and it is different in dynamic condition. The main issues are how to calculate the change of...

  1. Climate Change Potential Impacts on the Built Environment and Possible Adaptation Strategies

    Science.gov (United States)

    Quattrochi, Dale A.

    2014-01-01

    The built environment consists of components that exist at a range of scales from small (e.g., houses, shopping malls) to large (e.g., transportation networks) to highly modified landscapes such as cities. Thus, the impacts of climate change on the built environment may have a multitude of effects on humans and the land. The impact of climate change may be exacerbated by the interaction of different events that singly may be minor, but together may have a synergistic set of impacts that are significant. Also, mechanisms may exist wherein the built environment, particularly in the form of cities, may affect weather and the climate on local and regional scales. Hence, a city may be able to cope with prolonged heat waves, but if this is combined with severe drought, the overall result could be significant or even catastrophic, as accelerating demand for energy to cooling taxes water supplies needed both for energy supply and municipal water needs. This presentation surveys potential climate change impacts on the built environment from the perspective of the National Climate Assessment, and explores adaptation measures that can be employed to mitigate these impacts.

  2. [Changing economic environment of hospitals: management challenges of the 1990s].

    Science.gov (United States)

    Rotstein, Z; Noy, S; Goldman, B; Shani, M

    1990-12-16

    The modern hospital is an organization which is influenced by the external environment in which it functions. A major relevant area is the economic environment. In recent years the western world has been facing the challenge of rising costs of health care and an increase in their proportion to the gross national product of most countries. Consequently, hospitals as major providers of health care are under pressure from governments and health insurance companies to cut costs and to "produce" more efficiently. Since hospitals worldwide are finding it hard and painful to function in the new environment in which attitudes to hospitals are changing, a potential managerial-economic crisis may be the next phase. How can the hospital adapt to these changes? First, by adopting managerial attitudes and the tools of the business sector. These include: the strategic planning process, hospital operative autonomy, creating medical-economic responsibility centers as departments, cost-accounting for medical procedures, and case-mix budgeting. Management information systems are necessary during the transition. The hospital information system should include functions at the operative level, such as outpatient visits, and admissions and discharges of patients; and also clinical, diagnostic and laboratory procedures related to the patient case-mix. The second level is a management information system which includes salaries of personnel, case-mix budgeting with variance analysis, prices of procedures and epidemiological data. The authors believe that only the managerial approach combining medical and economic disciplines can meet the challenges of the changing modern economic environment. PMID:2074075

  3. Climate Change and Regulation in International and Regional Level, Especially the Built Environment

    Directory of Open Access Journals (Sweden)

    Putnoki Zsuzsanna

    2015-12-01

    Full Text Available The article starts with a brief insight into the history of climate change, with a scope on the international and legal aspects of ever-changing regulations. The regional level is in the article is The European Union, as the only regional economic integration organization under the Kyoto Protocol. It deals with the United Nation’s international agreements like UNFCCC its Kyoto’s Protocol and the Post-Kyoto era. It also analyses the EU’s system in the climate change law with correspondence the international rules. Comparison between international and regional legislation in the climate change is used as a tool of analysis. Finally an insight is given into a special field in the climate change, the build environment, reflecting on the related United Nation’s recommendation and the EU’s regulation.

  4. Changes in the acoustic environment alter the foraging and sheltering behaviour of the cichlid Amititlania nigrofasciata.

    Science.gov (United States)

    McLaughlin, Kirsty Elizabeth; Kunc, Hansjoerg P

    2015-07-01

    Anthropogenic noise can affect behaviour across a wide range of species in both terrestrial and aquatic environments. However, behaviours might not be affected in isolation. Therefore, a more holistic approach investigating how environmental stressors, such as noise pollution, affect different behaviours in concert is necessary. Using tank-based noise exposure experiments, we tested how changes in the acoustic environment affect the behaviour of the cichlid Amatitlania nigrofasciata. We found that exposure to anthropogenic noise affected a couple of behaviours: an increase in sheltering was accompanied by a decrease in foraging. Our results highlight the multiple negative effects of an environmental stressor on an individual's behaviour. PMID:25937344

  5. 76 FR 82011 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2011-12-29

    ..., 2011), 76 FR 55148 (September 6, 2011). By establishing this new class of market participant, the.... Thus, the Exchange may, in its discretion, take the following non- regulatory actions: (i) Revoke...

  6. Climate change and our environment: the effect on respiratory and allergic disease.

    Science.gov (United States)

    Barne, Charles; Alexis, Neil E; Bernstein, Jonathan A; Cohn, John R; Demain, Jeffrey G; Horner, Elliot; Levetin, Estelle; Nei, Andre; Phipatanakul, Wanda

    2013-03-01

    Climate change is a constant and ongoing process. It is postulated that human activities have reached a point at which we are producing global climate change. It provides suggestions to help the allergist/environmental physician integrate recommendations about improvements in outdoor and indoor air quality and the likely response to predicted alterations in the earth's environment into his or her patient's treatment plan. It incorporates references retrieved from Pub Med searches for topics, including:climate change, global warming, global climate change, greenhouse gasses, air pollution, particulates, black carbon, soot and sea level, as well as references contributed by the individual authors. Many changes that affect respiratory disease are anticipated.Examples of responses to climate change include energy reduction retrofits in homes that could potentially affect exposure to allergens and irritants, more hot sunny days that increase ozone-related difficulties, and rises in sea level or altered rainfall patterns that increase exposure to damp indoor environments.Climate changes can also affect ecosystems, manifested as the appearance of stinging and biting arthropods in new areas.Higher ambient carbon dioxide concentrations, warmer temperatures, and changes in floristic zones could potentially increase exposure to ragweed and other outdoor allergens,whereas green practices such as composting can increase allergen and irritant exposure. Finally, increased energy costs may resultin urban crowding and human source pollution, leading to changes in patterns of infectious respiratory illnesses. Improved governmental controls on airborne pollutants could lead to cleaner air and reduced respiratory diseases but will meet strong opposition because of their effect on business productivity. The allergy community must therefore adapt, as physician and research scientists always have, by anticipating the needs of patients and by adopting practices and research methods to

  7. Scientific and Regulatory Policy Committee (SRPC) paper: validation of digital pathology systems in the regulated nonclinical environment.

    Science.gov (United States)

    Long, Richard E; Smith, Adam; Machotka, Sam V; Chlipala, Elizabeth; Cann, Jennifer; Knight, Brian; Kawano, Yoshihiro; Ellin, Jesus; Lowe, Amanda

    2013-01-01

    Digital Pathology Systems (DPS) are dynamic, image-based computer systems that enable the acquisition, management, and interpretation of pathology information generated from digitized glass slides. This article provides a roadmap for (1) qualification of a whole slide scanner (WSS) during a validation project, (2) validation of software required to generate the whole slide image (WSI), and (3) an introduction to visual digital image evaluation and image analysis. It describes a validation approach that can be utilized when validating a DPS. It is not the intent of this article to provide guidance on when validation of DPS is required. Rather, the article focuses on technical aspects of validation of the WSS system (WSS, IT infrastructure, and associated software) portion of a DPS and covers the processes of setting up the WSS for scanning a glass slide through saving a WSI on a server. Validation of a computerized system, such as a DPS, for use in a regulated nonclinical environment is governed by Code of Federal Regulations (CFR) Title 21 part 11: Electronic Records; Electronic Signature and predicate rules associated with Good Laboratory Practices documents including 21 CFR part 58. Similar regulation and predicate rules apply in the European Union and Japan. PMID:22723045

  8. Nanotribological and Nanomechanical Properties Changes of Tooth After Bleaching and Remineralization in Wet Environment

    Science.gov (United States)

    Yu, Dandan; Gao, Shanshan; Min, Jie; Zhang, Qianqian; Gao, Shuai; Yu, Haiyang

    2015-12-01

    Teeth bleaching cases had increased with people's desire for oral aesthetic; however, bleached teeth would still undertake chewing actions and remineralizing process in saliva. Nanotribological and nanomechanical properties are proper displays for dental performance of bleached teeth. The purpose of the research was to reveal the effect of bleaching and remineralization on the nanotribological and nanomechanical properties of teeth in wet environment. The specimens were divided into four groups according to the bleaching products used: 12 % hydrogen peroxide (HP) (12HP group); 15 % carbamide peroxide (CP) (15CP group); 35 % CP (35CP group); and artificial saliva (control group). The nanotribological and nanomechanical property changes of tooth enamel after bleaching and remineralization were evaluated respectively by nanoscratch and nanoindentation tests in wet environment, imitating the wet oral environment. The morphology changes were evaluated by statistical parametric mapping (SPM) and scanning electron microscopy (SEM). After bleaching, 12HP group and 15CP group showed increased scratch depth with more pile ups on the scratch edges, decreased nanohardness, and corroded surface appearance. While the 35CP group showed an increase in nanoscratch depth, no change in nanohardness and surface appearance was observed. The control group showed no change in these measurements. After remineralization, the three bleaching groups showed decreased nanoscratch depth and no change of nanohardness compared with the bleached teeth. And the control group showed no changes in nanotribological and nanomechanical properties. The nanotribological and nanomechanical properties of the 12HP group and 15CP group were affected by bleaching, but the nanotribological properties recovered partly and the nanomechanical properties got no change after 1 week of remineralization. As for the 35CP group, the nanotribological properties were influenced and the nanomechanical properties were not

  9. Feature Optimization for Long-Range Visual Homing in Changing Environments

    Directory of Open Access Journals (Sweden)

    Qidan Zhu

    2014-02-01

    Full Text Available This paper introduces a feature optimization method for robot long-range feature-based visual homing in changing environments. To cope with the changing environmental appearance, the optimization procedure is introduced to distinguish the most relevant features for feature-based visual homing, including the spatial distribution, selection and updating. In the previous research on feature-based visual homing, less effort has been spent on the way to improve the feature distribution to get uniformly distributed features, which are closely related to homing performance. This paper presents a modified feature extraction algorithm to decrease the influence of anisotropic feature distribution. In addition, the feature selection and updating mechanisms, which have hardly drawn any attention in the domain of feature-based visual homing, are crucial in improving homing accuracy and in maintaining the representation of changing environments. To verify the feasibility of the proposal, several comprehensive evaluations are conducted. The results indicate that the feature optimization method can find optimal feature sets for feature-based visual homing, and adapt the appearance representation to the changing environments as well.

  10. Strategic Environmental Assessment Framework for Landscape-Based, Temporal Analysis of Wetland Change in Urban Environments

    Science.gov (United States)

    Sizo, Anton; Noble, Bram F.; Bell, Scott

    2016-03-01

    This paper presents and demonstrates a spatial framework for the application of strategic environmental assessment (SEA) in the context of change analysis for urban wetland environments. The proposed framework is focused on two key stages of the SEA process: scoping and environmental baseline assessment. These stages are arguably the most information-intense phases of SEA and have a significant effect on the quality of the SEA results. The study aims to meet the needs for proactive frameworks to assess and protect wetland habitat and services more efficiently, toward the goal of advancing more intelligent urban planning and development design. The proposed framework, adopting geographic information system and remote sensing tools and applications, supports the temporal evaluation of wetland change and sustainability assessment based on landscape indicator analysis. The framework was applied to a rapidly developing urban environment in the City of Saskatoon, Saskatchewan, Canada, analyzing wetland change and land-use pressures from 1985 to 2011. The SEA spatial scale was rescaled from administrative urban planning units to an ecologically meaningful area. Landscape change assessed was based on a suite of indicators that were subsequently rolled up into a single, multi-dimensional, and easy to understand and communicate index to examine the implications of land-use change for wetland sustainability. The results show that despite the recent extremely wet period in the Canadian prairie region, land-use change contributed to increasing threats to wetland sustainability.

  11. The StrongWomen Change Clubs: Engaging Residents to Catalyze Positive Change in Food and Physical Activity Environments

    Directory of Open Access Journals (Sweden)

    Rebecca A. Seguin

    2014-01-01

    Full Text Available Introduction. The epidemic of obesity is a multifaceted public health issue. Positive policy and environmental changes are needed to support healthier eating and increased physical activity. Methods. StrongWomen Change Clubs (SWCCs were developed through an academic-community research partnership between researchers at Cornell University and Tufts University and community partners (cooperative extension educators in rural towns in seven U.S. states. Extension educators served as the local leader and each recruited 10–15 residents to undertake a project to improve some aspect of the nutrition or physical activity environment. Most residents had limited (or no experience in civic engagement. At 6 and 12 months after implementation, the research team conducted key informant interviews with SWCC leaders to capture their perceptions of program process, benchmark achievement, and self-efficacy. Results. At 12 months, each SWCC had accomplished one benchmark; the majority had completed three or more benchmarks. They described common processes for achieving benchmarks such as building relationships and leveraging stakeholder partnerships. Barriers to benchmark achievement included busy schedules and resistance to and slow pace of change. Conclusion. Findings suggest that community change initiatives that involve stakeholders, build upon existing activities and organizational resources, and establish feasible timelines and goals can successfully catalyze environmental change.

  12. Climate change: Its possible impact on the environment and the people of northern regions

    International Nuclear Information System (INIS)

    A detailed overview is presented of the possible impacts of climate change on the Arctic environment, ecosystems, and human activities. The extent of global climate change is examined through the use of historical and paleoclimatologic records of temperature and stratospheric ozone. The effects of precipitation distribution and airborne particulates on climate change are also outlined. Changes in the Arctic are then examined, with an explanation of why global change in the Arctic is likely to be exaggerated. Likely scenarios of Arctic climate change involve milder winter temperatures, wetter and cloudier summers, more stormy weather and snowfall, greater variability in regional weather patterns, and dramatic changes in the extent of sea ice. Biological responses of wetland, northern forest, tundra, Arctic desert, below-ground, and marine ecosystems are assessed. Features of northern and Arctic ecosystems that may be particularly vulnerable to climate change are noted. Finally, the impacts of climate change on traditional activities and lifestyles, resource management and harvesting, agriculture, forestry, mining and fossil-fuel development, offshore operations, and human infrastructures are summarized. 5 figs

  13. Impact of climate change on the domestic indoor environment and associated health risks in the UK.

    Science.gov (United States)

    Vardoulakis, Sotiris; Dimitroulopoulou, Chrysanthi; Thornes, John; Lai, Ka-Man; Taylor, Jonathon; Myers, Isabella; Heaviside, Clare; Mavrogianni, Anna; Shrubsole, Clive; Chalabi, Zaid; Davies, Michael; Wilkinson, Paul

    2015-12-01

    There is growing evidence that projected climate change has the potential to significantly affect public health. In the UK, much of this impact is likely to arise by amplifying existing risks related to heat exposure, flooding, and chemical and biological contamination in buildings. Identifying the health effects of climate change on the indoor environment, and risks and opportunities related to climate change adaptation and mitigation, can help protect public health. We explored a range of health risks in the domestic indoor environment related to climate change, as well as the potential health benefits and unintended harmful effects of climate change mitigation and adaptation policies in the UK housing sector. We reviewed relevant scientific literature, focusing on housing-related health effects in the UK likely to arise through either direct or indirect mechanisms of climate change or mitigation and adaptation measures in the built environment. We considered the following categories of effect: (i) indoor temperatures, (ii) indoor air quality, (iii) indoor allergens and infections, and (iv) flood damage and water contamination. Climate change may exacerbate health risks and inequalities across these categories and in a variety of ways, if adequate adaptation measures are not taken. Certain changes to the indoor environment can affect indoor air quality or promote the growth and propagation of pathogenic organisms. Measures aimed at reducing greenhouse gas emissions have the potential for ancillary public health benefits including reductions in health burdens related heat and cold, indoor exposure to air pollution derived from outdoor sources, and mould growth. However, increasing airtightness of dwellings in pursuit of energy efficiency could also have negative effects by increasing concentrations of pollutants (such as PM2.5, CO and radon) derived from indoor or ground sources, and biological contamination. These effects can largely be ameliorated by mechanical

  14. Flocking for swarm systems with fixed topology in a changing environment

    Institute of Scientific and Technical Information of China (English)

    Zonggang LI; Yingmin JIA

    2008-01-01

    This paper is mainly devoted to the flocking of a class of swarm with fixed topology in a changing environment.Firstly,the controller for each agent is proposed by employing the error terms between the state of the agent and the average state of its neighbors.Secondly,a sufficient condition for the swarm to achieve flocking is presented under assumptions that the gradient of the environment is bounded and the initial position graph is connected.Thirdly,as the environment is a plane,it is further proved that the velocity of each agent finally converges to the velocity of the swarm center although not one agent knows where the center of the group is.Finally,numerical examples are included to illustrate the obtained results.

  15. The change in body stressed to relaxed body through breathing, visualization and a protective environment together

    Directory of Open Access Journals (Sweden)

    Evelyn I. Rodríguez Morrill

    2009-11-01

    Full Text Available This work shows several ways to meet and relax the body through personal knowledge and techniques encounter with nature. Modern life and fast, the constant pressure from childhood to adulthood, in the modes of interaction between individuals and groups, they lead to construction of bodies that reflect emotional anatomy visible loss of balance, contractures, inflammation, multiple imbalances by lack of knowledge and awareness especially being in the world fully, the person has moved away from its ecological relationship with itself and the environment. Methods are shown to positively change a condition of constant stress and chronic discomfort, a learned condition of physical and psychological wellbeing, with a series of movements, recovering the body through exercise, to tend to personal balance, obtaining a positive relationship with the environment and the people attended. The proposal starts promoting new habits that can be saved in consciousness. Partly, mainly of breath, alignment with the music and the environment and personal and group work

  16. Environment

    Czech Academy of Sciences Publication Activity Database

    Tošovská, Eva

    Prague: Charles University in Prague, Center for Economic Research and Graduate Education , 2006 - (Zemčík, P.; Žigić, K.), s. 62-66 ISBN 80-7343-110-6 Institutional research plan: CEZ:AV0Z70850503 Keywords : environment * Czech Republic Subject RIV: AH - Economics http://www.cerge-ei.cz/publications/books/

  17. Facilitation among plants in alpine environments in the face of climate change.

    Science.gov (United States)

    Anthelme, Fabien; Cavieres, Lohengrin A; Dangles, Olivier

    2014-01-01

    While there is a large consensus that plant-plant interactions are a crucial component of the response of plant communities to the effects of climate change, available data remain scarce, particularly in alpine systems. This represents an important obstacle to making consistent predictions about the future of plant communities. Here, we review current knowledge on the effects of climate change on facilitation among alpine plant communities and propose directions for future research. In established alpine communities, while warming seemingly generates a net facilitation release, earlier snowmelt may increase facilitation. Some nurse plants are able to buffer microenvironmental changes in the long term and may ensure the persistence of other alpine plants through local migration events. For communities migrating to higher elevations, facilitation should play an important role in their reorganization because of the harsher environmental conditions. In particular, the absence of efficient nurse plants might slow down upward migration, possibly generating chains of extinction. Facilitation-climate change relationships are expected to shift along latitudinal gradients because (1) the magnitude of warming is predicted to vary along these gradients, and (2) alpine environments are significantly different at low vs. high latitudes. Data on these expected patterns are preliminary and thus need to be tested with further studies on facilitation among plants in alpine environments that have thus far not been considered. From a methodological standpoint, future studies will benefit from the spatial representation of the microclimatic environment of plants to predict their response to climate change. Moreover, the acquisition of long-term data on the dynamics of plant-plant interactions, either through permanent plots or chronosequences of glacial recession, may represent powerful approaches to clarify the relationship between plant interactions and climate change. PMID:25161660

  18. Late Oligocene sedimentary environments and provenance abrupt change event in the northern South China Sea

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A significant change in composition was recorded in late Oligocene sediments from the northern South China Sea.This abrupt event coincided with the seafloor spreading axis jump across the Oligocene/Miocene boundary,leading to sedimentation breaks and slumps as well as obvious changes in sediment geochemical composition,and representing the greatest tectonic activity in the South China Sea region since the Oligocene.Through this tectonic event,the sedimentary environment in the Baiyun sag area transformed from a continental shelf in the late Oligocene to a continental slope since the early Miocene,the provenance of the sediments changed from neighboring areas to the hinterland of the South China block,and the sea level rose since the early Miocene in the area.Therefore,this abrupt change event has a profound influence on the evolution of petroleum offshore in the northern South China Sea.

  19. Recruitment in a changing environment: the 2000s North Sea herring recruitment failure

    DEFF Research Database (Denmark)

    Payne, Mark; Hatfield, E.M.C.; Dickey-Collas, M.;

    2009-01-01

    likely alleviate the problem. This illustrates again that recruitment is influenced by more than just spawning-stock biomass, and that changes in other factors can be of equal, or even greater, importance. In such dynamically changing environments, recent management success does not necessarily guarantee......Environmentally induced change appears to be impacting the recruitment of North Sea herring (Clupea harengus). Despite simultaneously having a large adult population, historically low exploitation, and Marine Stewardship Council accreditation (implying sustainability), there have been an...... unprecedented 6 sequential years of poor juvenile production (recruitment). Analysis suggests that the poor recruitment arises during the larval overwintering phase, with recent survival rates greatly reduced. Contemporary warming of the North Sea has caused significant changes in the plankton community, and a...

  20. Climate change damage functions in LCA – (1) from global warming potential to natural environment damages

    DEFF Research Database (Denmark)

    Callesen, Ingeborg; Hauschild, Michael Zwicky; Bagger Jørgensen, Rikke;

    Energy use often is the most significant contributor to the impact category ‘global warming’ in life cycle impact assessment. However, the potential global warming effects on the climate at regional level and consequential effects on the natural environment are not thoroughly described within LCA...... methodology. The current scientific understanding of the extent of climate change impacts is limited due to the immense complexity of the multi-factorial environmental changes and unknown adaptive capacities at process, species and ecosystem level. In the presentation we argue that the global warming impacts...

  1. Climate change enhances the mobilisation of naturally occurring metals in high altitude environments.

    Science.gov (United States)

    Zaharescu, Dragos G; Hooda, Peter S; Burghelea, Carmen I; Polyakov, Viktor; Palanca-Soler, Antonio

    2016-08-01

    Manmade climate change has expressed a plethora of complex effects on Earth's biogeochemical compartments. Climate change may also affect the mobilisation of natural metal sources, with potential ecological consequences beyond mountains' geographical limits; however, this question has remained largely unexplored. We investigated this by analysing a number of key climatic factors in relationship with trace metal accumulation in the sediment core of a Pyrenean lake. The sediment metal contents showed increasing accumulation trend over time, and their levels varied in step with recent climate change. The findings further revealed that a rise in the elevation of freezing level, a general increase in the frequency of drier periods, changes in the frequency of winter freezing days and a reducing snow cover since the early 1980s, together are responsible for the observed variability and augmented accumulation of trace metals. Our results provide clear evidence of increased mobilisation of natural metal sources - an overlooked effect of climate change on the environment. With further alterations in climate equilibrium predicted over the ensuing decades, it is likely that mountain catchments in metamorphic areas may become significant sources of trace metals, with potentially harmful consequences for the wider environment. PMID:27093125

  2. 3. Neural changes in different gravity and ecophysiological environments - A survey

    Science.gov (United States)

    Slenzka, K.

    Neural changes or neuronal plasticity occur after and during different stimulations and inputs in general. Gravity is one major input to the brain transferred from the vestibular system. However, often also direct effects of gravity on the cellular level are discussed. Our group was investigating the influence of different gravity environments on a large variety of neuronal enzymes in the developing fish brain. Long-term space travel or bases on Moon and Mars will have to deal not only with neural changes based on the different gravity environment, but also with potential negative or even toxic changes in the respective life support system. Our goal is now to identify reported enzyme activity changes in the brain based for example on potential toxic drugs or endocrine disruptors in combination with gravity induced changes. In this paper a survey will be undertaken discussing recent results obtained in ecotoxicology, gravitational biology combined with new data from our group regarding potential differences in brain glucose-6-phosphate dehydrogenase of medaka and zebrafish.

  3. Book Review: Late Cenozoic Climate Change in Asia: Loess, Monsoon and Monsoon-arid Environment Evolution

    Science.gov (United States)

    Clemens, Steven C.

    2015-01-01

    Loess-Paleosol deposits drape >500,000 km2 of eastern China, spanning environments from the humid, monsoon-influenced regions near the coast to the arid, westerlies-dominated regions inland. Sections, up to hundreds of meters thick, are exposed in deeply incised river valleys and can be accessed as well by drilling. Combined, the high sedimentation rates and extensive geographic coverage make these sections unique among global terrestrial sediment archives. The Chinese loess-paleosol sequences, and the arid interior regions to the northwest, record diverse aspects of geologic and environmental change ranging from the tectonic evolution of the Tibetan Plateau (106 year time scale) through glacial-interglacial scale changes in global ice volume and greenhouse gasses (105 year time scale) on down through the orbital (104 years) to millennial and centennial scale events (103-102 year) relevant to the underpinnings of human interactions with changing environmental pressures. 'Late Cenozoic Climate Chang in Asia: Loess, Monsoon and Monsoon-arid Environment Evolution' is a timely contribution that synthesizes findings derived from the extensive work in these areas, places the findings in the broader context of global climate change and helps to define avenues for future research.

  4. A Governing Framework for Climate Change Adaptation in the Built Environment

    Directory of Open Access Journals (Sweden)

    Daniel A. Mazmanian

    2013-12-01

    Full Text Available Developing an approach to governing adaptation to climate change is severely hampered by the dictatorship of the present when the needs of future generations are inadequately represented in current policy making. We posit this problem as a function of the attributes of adaptation policy making, including deep uncertainty and nonstationarity, where past observations are not reliable predictors of future outcomes. Our research links organizational decision-making attributes with adaptation decision making and identifies cases in which adaptation actions cause spillovers, free riding, and distributional impacts. We develop a governing framework for adaptation that we believe will enable policy, planning, and major long-term development decisions to be made appropriately at all levels of government in the face of the deep uncertainty and nonstationarity caused by climate change. Our framework requires that approval of projects with an expected life span of 30 years or more in the built environment include minimum building standards that integrate forecasted climate change impacts from the Intergovernmental Panel on Climate Change (IPCC intermediate scenario. The intermediate IPCC scenario must be downscaled to include local or regional temperature, water availability, sea level rise, susceptibility to forest fires, and human habitation impacts to minimize climate-change risks to the built environment. The minimum standard is systematically updated every six years to facilitate learning by formal and informal organizations. As a minimum standard, the governance framework allows jurisdictions to take stronger actions to increase their climate resilience and thus maintain system flexibility.

  5. The Changing Farming Environment in Tanzania: The Case of Selected Villages in Kilimanjaro

    OpenAIRE

    Bee, Faustine K; NGAILO, Legnard N.; Yoshida, Masao

    1997-01-01

    This study examines the changing farming environment among the small-holder farmers in Tanzania under the ongoing world-wide economic reform measures. Various economic reform measures being implemented have far-reaching effects on farming behaviour. Small farmers have increasingly done away with the production of the traditional export crops and instead have shifted to the product of quick-selling crops such as vegetables and paddy. It was observed that most farmers are facing serious economi...

  6. Metal release from contaminated estuarine sediment under pH changes in the marine environment

    OpenAIRE

    Martin-Torre, C; PAYAN, C; Verbinnen, B; Coz, A.; Ruiz, G.; Vandecasteele, C; Viguri, R

    2015-01-01

    The contaminant release from estuarine sediment due to pH changes was investigated using a modified CEN/TS 14429 pH-dependence leaching test. The test is performed in the range of pH values of 0–14 using deionised water and seawater as leaching solutions. The experimental conditions mimic different circumstances of the marine environment due to the global acidification, carbon dioxide (CO2) leakages from carbon capture and sequestration technologies, and accidental chemical spills in seawater...

  7. Changes in Marine Environments and Responses of Ecosystem Dynamics in the East Asian Pacific

    Science.gov (United States)

    Ogawa, Hiroshi; Saito, Hiroaki; Ju, Se-Jong

    2014-02-01

    At an international symposium on the marine systems of the Pacific region of East Asia, scientists concluded that changes in the ocean environment are having a significant effect on biogeochemical cycles and ecosystems and, consequently, on humans and the food supply. The meeting, the 6th China-Japan-Korea (CJK) Integrated Marine Biogeochemistry and Ecosystem Research symposium, was held in Japan at the University of Tokyo.

  8. Property changes induced by the space environment in polymeric materials on LDEF

    Energy Technology Data Exchange (ETDEWEB)

    Whitaker, A.F.; Finckenor, M.M.; Kamenetzky, R.R. (NASA, Marshall Space Flight Center, Huntsville, AL (United States))

    1992-01-01

    Property changes that occurred in four groups of polymer-based materials in the Long Duration Exposure Facility (LDEF) due to exposure to the outer space environment for 5.8 yrs are examined. Evaluations of contamination and mass loss are presented along with optical, thermal, and electrical analyses and mechanical property evaluations for TFE Teflon, the fluorinated material Halar, the silicone-based material RTV 511, and PEEK resin. 5 refs.

  9. Property changes induced by the space environment in polymeric materials on LDEF

    International Nuclear Information System (INIS)

    Property changes that occurred in four groups of polymer-based materials in the Long Duration Exposure Facility (LDEF) due to exposure to the outer space environment for 5.8 yrs are examined. Evaluations of contamination and mass loss are presented along with optical, thermal, and electrical analyses and mechanical property evaluations for TFE Teflon, the fluorinated material Halar, the silicone-based material RTV 511, and PEEK resin. 5 refs

  10. Property changes induced by the space environment in polymeric materials on LDEF

    Science.gov (United States)

    Whitaker, Ann F.; Finckenor, Miria M.; Kamenetzky, Rachel R.

    1992-01-01

    Property changes that occurred in four groups of polymer-based materials in the Long Duration Exposure Facility (LDEF) due to exposure to the outer space environment for 5.8 yrs are examined. Evaluations of contamination and mass loss are presented along with optical, thermal, and electrical analyses and mechanical property evaluations for TFE Teflon, the fluorinated material Halar, the silicone-based material RTV 511, and PEEK resin.

  11. The development and change study of cost accounting in the IT environment

    Institute of Scientific and Technical Information of China (English)

    Zilian Li; Qiumei Hu

    2015-01-01

    Relative to costs of computerized accounting, the cost accounting information further to get rid of the shackles of artificial accounting, reflecting a pure information management thinking, which contains a richer content, and traditional cost accounting theory a profound impact on the system. Clear understanding of the environment in the IT development process cost accounting will help us actively to promote cost accounting change, innovation and development.

  12. Managing Price Risk in a Changing Policy Environment: The Case of the EU Dairy Industry

    OpenAIRE

    O'Connor, Declan; Keane, Michael; Barnes, Edel

    2008-01-01

    The EU dairy industry faces an unprecedented level of change. The anticipated removal of milk quotas and the move to a less restricted global trade environment will provide the industry with both opportunities and challenges. The primary challenge will be the need for the industry to deal with more volatile prices. Active management of the risks associated with these more volatile prices will help to place the industry in a more competitive position. However this will require the industry and...

  13. Complexity in organizations and environment - adaptive changes and adaptive decision-making

    Directory of Open Access Journals (Sweden)

    Robert Fabac

    2010-07-01

    Full Text Available The features of complexity are ever more present in modern organizations and in environments in which they operate, trying to survive and be as competitive as possible. In the processes of, the so-called emergence, the formal organizational structure, designed purposefully and with a plan, is going through a change due to complexity and the need for adaptation. As a result, there is a variety of new informal groups. At the same time, the intended structural changes and business process changes occur because of the perception that the leadership and senior organizational management have of the strategic situation. Managers in modern organizations often use business intelligence (BI systems when making important business decisions. These systems offer support to the decision-making by gathering and processing relevant data and information about the company performance, but also about the data on conditions in close and remote environment. A modern company is characterized by the complex adaptive system, but the environment in which it operates together with other business subjects (agents is also complex. Consequently, the requirements for appropriate or optimal decisions and successfully completed activities are hard to meet. Given that expected future events and circumstances often occur in nonlinear mechanisms, the decisions made by following the models of traditional predicting and planning are not satisfactory. This calls for new approaches to decision making and acting.

  14. Population-environment drivers of H5N1 avian influenza molecular change in Vietnam.

    Science.gov (United States)

    Carrel, Margaret A; Emch, Michael; Nguyen, Tung; Todd Jobe, R; Wan, Xiu-Feng

    2012-09-01

    This study identifies population and environment drivers of genetic change in H5N1 avian influenza viruses (AIV) in Vietnam using a landscape genetics approach. While prior work has examined how combinations of local-level environmental variables influence H5N1 occurrence, this research expands the analysis to the complex genetic characteristics of H5N1 viruses. A dataset of 125 highly pathogenic H5N1 AIV isolated in Vietnam from 2003 to 2007 is used to explore which population and environment variables are correlated with increased genetic change among viruses. Results from non-parametric multidimensional scaling and regression analyses indicate that variables relating to both the environmental and social ecology of humans and birds in Vietnam interact to affect the genetic character of viruses. These findings suggest that it is a combination of suitable environments for species mixing, the presence of high numbers of potential hosts, and in particular the temporal characteristics of viral occurrence, that drive genetic change among H5N1 AIV in Vietnam. PMID:22652510

  15. How External Environment and Internal Organization contribute in Commitment to Change? (Study at organizational change in state owned organizations in Indonesia)

    OpenAIRE

    Wustari Mangundjaya; Budi Soetjipto

    2014-01-01

    The success of organizational change was influenced by many factors, and some of them are the conditions of external environments and internal organization. This study is trying to identify the role and contribution of employee’s perception about external environment and internal organization in relations with commitment to change. The study was conducted at financial state owned organizations with 539 respondents, using Organizational Trust and Organizational Task Environment as data collect...

  16. Remedial action plan for the inactive uranium processing site at Naturita, Colorado. DOE responses to comments from U.S. Nuclear Regulatory Commission and Colorado Department of Public Health and Environment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-16

    This report contains responses by the US Department of Energy to comments from the US Nuclear Regulatory Commission and the Colorado Department of Public Health and Environment on the Naturita remedial action plan. This was done in an attempt to clarify information. The site is an inactive uranium processing site at Naturita, Colorado.

  17. Remedial action plan for the inactive uranium processing site at Naturita, Colorado. DOE responses to comments from U.S. Nuclear Regulatory Commission and Colorado Department of Public Health and Environment

    International Nuclear Information System (INIS)

    This report contains responses by the US Department of Energy to comments from the US Nuclear Regulatory Commission and the Colorado Department of Public Health and Environment on the Naturita remedial action plan. This was done in an attempt to clarify information. The site is an inactive uranium processing site at Naturita, Colorado

  18. Serial Changes of CD4+CD25+FoxP3+ Regulatory T Cell in Canine Model of Sepsis Induced by Endotoxin

    OpenAIRE

    YU, Dohyeon; Kim, Junhwan; Park, Chul; Park, Jinho

    2014-01-01

    ABSTRACT Regulatory T cells (Tregs) suppress the immune system and maintain the homeostasis of the immune system in healthy dogs. In septic patients, the percentage of circulating Tregs is increasing, which may cause the sepsis-induced immunosuppression. This study was performed to investigate the changes of the percentage of Tregs in total lymphocytes of the peripheral blood in the experimental canine endotoxemia model. The animals injected with a high dose lipopolysaccharide (LPS) induced s...

  19. Dynamic changes in CD45RA−Foxp3high regulatory T-cells in chronic hepatitis C patients during antiviral therapy

    OpenAIRE

    Zhiqin Li; Yu Ping; Zujiang Yu; Meng Wang; Dongli Yue; Zhen Zhang; Jianbin Li; Bin Zhang,; Xuezhong Shi; Yi Zhang

    2016-01-01

    Objectives: CD4+Foxp3+ regulatory T-cells (Treg) are known to accumulate under certain pathological conditions. This study was conducted to evaluate the characteristics of and dynamic changes in Treg cells in chronic hepatitis C (CHC) patients during antiviral therapy. Methods: One hundred and forty-five subjects were enrolled in this study, including 105 CHC patients and 40 healthy donors. The phenotypes and functions of Treg cells were analyzed by flow cytometry. Results: A significan...

  20. Changing tides: Adaptive monitoring, assessment, and management of pharmaceutical hazards in the environment through time.

    Science.gov (United States)

    Gaw, Sally; Brooks, Bryan W

    2016-04-01

    Pharmaceuticals are ubiquitous contaminants in aquatic ecosystems. Adaptive monitoring, assessment, and management programs will be required to reduce the environmental hazards of pharmaceuticals of concern. Potentially underappreciated factors that drive the environmental dose of pharmaceuticals include regulatory approvals, marketing campaigns, pharmaceutical subsidies and reimbursement schemes, and societal acceptance. Sales data for 5 common antidepressants (duloxetine [Cymbalta], escitalopram [Lexapro], venlafaxine [Effexor], bupropion [Wellbutrin], and sertraline [Zoloft]) in the United States from 2004 to 2008 were modeled to explore how environmental hazards in aquatic ecosystems changed after patents were obtained or expired. Therapeutic hazard ratios for Effexor and Lexapro did not exceed 1; however, the therapeutic hazard ratio for Zoloft declined whereas the therapeutic hazard ratio for Cymbalta increased as a function of patent protection and sale patterns. These changes in therapeutic hazard ratios highlight the importance of considering current and future drivers of pharmaceutical use when prioritizing pharmaceuticals for water quality monitoring programs. When urban systems receiving discharges of environmental contaminants are examined, water quality efforts should identify, prioritize, and select target analytes presently in commerce for effluent monitoring and surveillance. PMID:26412644

  1. Expert views on societal responses to different applications of nanotechnology: a comparative analysis of experts in countries with different economic and regulatory environments

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Nidhi, E-mail: guptanidhi12@gmail.com; Fischer, Arnout R. H., E-mail: arnout.fischer@wur.nl [Wageningen University, Marketing and Consumer Behaviour Group (Netherlands); George, Saji, E-mail: saji_george@nyp.gov.sg [Nanyang Polytechnic, Centre for Sustainable Nanotechnology, School of Chemical and Life Sciences (Singapore); Frewer, Lynn J., E-mail: lynn.frewer@newcastle.ac.uk [Newcastle University, School of Agriculture, Food and Rural Development (United Kingdom)

    2013-08-15

    The introduction of different applications of nanotechnology will be informed by expert views regarding which (types of) application will be most societally acceptable. Previous research in Northern Europe has indicated that experts believe that various factors will be influential, predominant among these being public perceptions of benefit, need and consumer concern about contact with nanomaterials. These factors are thought by experts to differentiate societal acceptance and rejection of nanotechnology applications. This research utilises a larger sample of experts (N = 67) drawn from Northern America, Europe, Australasia, India and Singapore to examine differences in expert opinion regarding societal acceptance of different applications of nanotechnology within different technological environments, consumer cultures and regulatory regimes. Perceived risk and consumer concerns regarding contact with nano-particles are thought by all experts to drive rejection, and perceived benefits to influence acceptance, independent of country. Encapsulation and delivery of nutrients in food was thought to be the most likely to raise societal concerns, while targeted drug delivery was thought most likely to be accepted. Lack of differentiation between countries suggests that expert views regarding social acceptance may be homogenous, independent of local contextual factors.

  2. Expert views on societal responses to different applications of nanotechnology: a comparative analysis of experts in countries with different economic and regulatory environments

    International Nuclear Information System (INIS)

    The introduction of different applications of nanotechnology will be informed by expert views regarding which (types of) application will be most societally acceptable. Previous research in Northern Europe has indicated that experts believe that various factors will be influential, predominant among these being public perceptions of benefit, need and consumer concern about contact with nanomaterials. These factors are thought by experts to differentiate societal acceptance and rejection of nanotechnology applications. This research utilises a larger sample of experts (N = 67) drawn from Northern America, Europe, Australasia, India and Singapore to examine differences in expert opinion regarding societal acceptance of different applications of nanotechnology within different technological environments, consumer cultures and regulatory regimes. Perceived risk and consumer concerns regarding contact with nano-particles are thought by all experts to drive rejection, and perceived benefits to influence acceptance, independent of country. Encapsulation and delivery of nutrients in food was thought to be the most likely to raise societal concerns, while targeted drug delivery was thought most likely to be accepted. Lack of differentiation between countries suggests that expert views regarding social acceptance may be homogenous, independent of local contextual factors

  3. EU-China Cooperation In the Field of Energy, Environment and Climate Change

    Directory of Open Access Journals (Sweden)

    Pietro De Matteis

    2010-11-01

    Full Text Available The evolution of the energy market and the intrinsic worldwide scope of environmental threats, such as climate change, are two elements that have pushed the world towards shared approaches to global governance via bilateral institutions and international regimes. This article, with the aid of an institutionalist approach, presents the current status of the EU-China relationship, which is characterised by high institutionalisation, and it underlines how their bilateral cooperation has progressively focused on energy and climate change-related issues. In particular, the article sheds some light on the linkages between energy, environment and climate change and how these have created the basis for the upgrade of the EU-China bilateral relationship to its current level. To do so, it underlines some of the tools, the main frameworks and some of the key outcomes of their bilateral cooperation in these fields.

  4. Adaptation measures for climate change and the urban heat island in Japan's built environment

    International Nuclear Information System (INIS)

    Climate change scenarios are discussed for Japan with clear implications drawn for the built environment in terms of increased temperatures of 4-5oC, rising sea levels and subterranean water tables. Research on the impacts and adaptation measures for global warming in Japan is reviewed. One of the most significant impacts of climate change in Japan will exacerbate the existing heat island phenomenon in cities by absorbing increased solar radiation. This will lead to further increases in temperatures in an urban microclimate with negative implications for energy and water consumption, human health and discomfort, and local ecosystems. The current urban heat island phenomenon and its impacts are described. The relationships between climate change and urban heat island impacts are discussed. Potential adaptation measures to those impacts are also discussed and proposed. (author)

  5. Making decisions in an ever-changing environment - A research agenda

    Directory of Open Access Journals (Sweden)

    Bela Pataki

    2013-04-01

    Full Text Available Simon recognized the limitations of the classical normative decision theory and established descriptive theory. His concept of bounded rationality and administrative behavior was a big step ahead, but the world has changed dramatically since then. Multiple, continuous changes have become normal, which brings up new problems on the decision maker’s and on the organization’s level as well. It became usual that the decision maker is not able to define preferences for lack of knowledge and have to learn or delegate much more frequently than before. In the same time the organization should be more resilient or nimble in this ever-changing environment. The authors outline a research agenda on both levels: some about the continuous learning and frequent delegating, and some about the HRM and IT-management issues of organizational nimbleness.

  6. Footprints of air pollution and changing environment on the sustainability of built infrastructure.

    Science.gov (United States)

    Kumar, Prashant; Imam, Boulent

    2013-02-01

    Over 150 research articles relating three multi-disciplinary topics (air pollution, climate change and civil engineering structures) are reviewed to examine the footprints of air pollution and changing environment on the sustainability of building and transport structures (referred as built infrastructure). The aim of this review is to synthesize the existing knowledge on this topic, highlight recent advances in our understanding and discuss research priorities. The article begins with the background information on sources and emission trends of global warming (CO(2), CH(4), N(2)O, CFCs, SF(6)) and corrosive (SO(2), O(3), NO(X)) gases and their role in deterioration of building materials (e.g. steel, stone, concrete, brick and wood) exposed in outdoor environments. Further section covers the impacts of climate- and pollution-derived chemical pathways, generally represented by dose-response functions (DRFs), and changing environmental conditions on built infrastructure. The article concludes with the discussions on the topic areas covered and research challenges. A comprehensive inventory of DRFs is compiled. The case study carried out for analysing the inter-comparability of various DRFs on four different materials (carbon steel, limestone, zinc and copper) produced comparable results. Results of another case study revealed that future projected changes in temperature and/or relatively humidity are expected to have a modest effect on the material deterioration rate whereas changes in precipitation were found to show a more dominant impact. Evidences suggest that both changing and extreme environmental conditions are expected to affect the integrity of built infrastructure both in terms of direct structural damage and indirect losses of transport network functionality. Unlike stone and metals, substantially limited information is available on the deterioration of brick, concrete and wooden structures. Further research is warranted to develop more robust and

  7. The Working Environment and Changing Role of Corporate Librarians in Taiwan

    Directory of Open Access Journals (Sweden)

    Hsueh-hua Chen

    2003-06-01

    Full Text Available Influenced by the concept of “Knowledge Economics”, knowledge management (KM is getting a lot of attention in the field of business administration recently. Corporate centers are mostly affected by KM either in their working environment or in the role of their daily operation in the field of Library and Information Science. In the United States, the Special Library Association (SLA conducted numerous studies about the working environment and the changing role of corporate librarians in the past ten years. Due to the differences in politics, economics, and culture between Taiwan and the western countries, the organizational structure and corporate culture of the enterprise will not be exactly the same. Therefore, local studies on similar topics are needed. The purpose of this study is to explore the influence of the KM on the working environment and the changing roles of the corporate librarians in Taiwan based on the result of National Science Council Research Project executed by the authors.[Article content in Chinese

  8. 76 FR 61422 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing of Proposed Rule Change Amending...

    Science.gov (United States)

    2011-10-04

    ... designed to restore investor confidence by reducing the potential for excessive market volatility. Among... FR 31647 (June 1, 2011). The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues... trading at specified levels in order to promote stability and investor confidence during a period...

  9. 76 FR 9843 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change...

    Science.gov (United States)

    2011-02-22

    ... CFR 240.19b-4. \\3\\ See Securities Exchange Act Release No. 63636 (January 3, 2011), 76 FR 1477... sales and marketing materials, and certain regulatory compliance matters. The Distributor will not open... Leveraged Fund will purchase a sufficient number of Long Index Futures Contracts targeting a long...

  10. 76 FR 79741 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Science.gov (United States)

    2011-12-22

    ... interest rates, inflation rates, exchange rates, monetary and fiscal policies, trade and current account... dividends, interest and net short-term capital gains in excess of any net long- term capital losses) and (ii...\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of Substance of...

  11. 78 FR 13387 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing of Proposed Rule Change...

    Science.gov (United States)

    2013-02-27

    ... Book. \\4\\ See Securities Exchange Act Release Nos. 59638 (March 27, 2009), 74 FR 15020 (April 2, 2009... period before responding to exposed orders so as to minimize market risk. BOX believes that even reducing... necessary or appropriate in furtherance of the purposes of the Act. C. Self-Regulatory...

  12. 75 FR 38576 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NYSE Arca, Inc. To...

    Science.gov (United States)

    2010-07-02

    ... of the votes cast in the same uncontested election, then the independent directors who received a.... 61947 (April 20, 2010), 75 FR 22169 (April 27, 2010) (SR-NYSE-2010-18). II. Self-Regulatory Organization...\\ \\15\\ See Securities Exchange Act Release No. 61947 (April 20, 2010), 75 FR 22169 (April 27, 2010)...

  13. 75 FR 76050 - Notice of the Nuclear Regulatory Commission Consent to Indirect Change of Control and Issuance of...

    Science.gov (United States)

    2010-12-07

    ..., Decommissioning and Uranium Recovery Licensing Directorate, Division of Waste Management and Environmental... Federal Register on September 20, 2010 (75 FR 57300) with a deadline for submitting a request for hearing... Nuclear Regulatory Commission. Keith I. McConnell, Deputy Director, Decommissioning and Uranium...

  14. 77 FR 74528 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Amending...

    Science.gov (United States)

    2012-12-14

    ... Exchange notes that some institutional investors have raised concerns that by not executing against larger... legitimate trading interest entered on behalf of institutional investors. B. Self-Regulatory Organization's... investors. While the Exchange continues to believe that the purpose of the PL Select Order not to...

  15. 76 FR 28826 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change by...

    Science.gov (United States)

    2011-05-18

    ... Act Release No. 34-54714 at 4 (November 6, 2006), 71 FR 66352 (November 14, 2006). B. Self-Regulatory... (``IOC'') \\6\\ offer to sell 100 shares at $10.11 is entered into the BATS Book, such order will be... incoming order was not an IOC, and thus, was eligible for posting, then the offer would be posted to...

  16. 76 FR 28830 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change by...

    Science.gov (United States)

    2011-05-18

    ... Act Release No. 34-54714 at 4 (November 6, 2006), 71 FR 66352 (November 14, 2006). B. Self-Regulatory... (``IOC'') \\6\\ offer to sell 100 shares at $10.11 is entered into the BATS Book, such order will be... incoming order was not an IOC, and thus, was eligible for posting, then the offer would be posted to...

  17. 77 FR 36307 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Amending...

    Science.gov (United States)

    2012-06-18

    ... Corporate Governance Code that would be added, given that Holdco was formed under and subject to the laws of...-72), 77 FR 3297. NYSE Arca explained the reasons for incorporating the Proposed Amendments in Holdco... corporate governance and regulatory obligations that are addressed by means of ownership and...

  18. 77 FR 36324 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing of Proposed Rule Change Amending...

    Science.gov (United States)

    2012-06-18

    ... independence standards and criteria in the Dutch Corporate Governance Code that would be added, given that...-51; SR-NYSEAmex-2011-78; SR-NYSEArca-2011-72), 77 FR 3297. NYSE MKT explained the reasons for... subsidiaries, it is subject to various corporate governance and regulatory obligations that are addressed...

  19. 76 FR 21085 - Self-Regulatory Organizations; NASDAQ Stock Market, LLC; Order Approving Proposed Rule Change To...

    Science.gov (United States)

    2011-04-14

    ... NASDAQ in its filing, the other Boards of Directors of the regulatory subsidiaries of NASDAQ OMX have... Act Release No. 63925 (February 17, 2011), 76 FR 10418 (February 24, 2011) (``Notice''). II... limited liability company.\\4\\ \\4\\ See Securities Exchange Act Release No. 62783 (August 27, 2010), 75...

  20. Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

    NARCIS (Netherlands)

    Morikawa, Hiromasa; Ohkura, Naganari; Vandenbon, Alexis; Itoh, Masayoshi; Nagao-Sato, Sayaka; Kawaji, Hideya; Lassmann, Timo; Carninci, Piero; Hayashizaki, Yoshihide; Forrest, Alistair R R; Standley, Daron M; Date, Hiroshi; Sakaguchi, Shimon; Clevers, Hans

    2014-01-01

    Naturally occurring regulatory T (Treg) cells, which specifically express the transcription factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-tolerance and homeostasis. By transcriptional start site cluster analysis, we assessed here how genome-wide patterns of DNA

  1. 75 FR 26304 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NYSE Arca, Inc...

    Science.gov (United States)

    2010-05-11

    ... governance committee.\\6\\ \\3\\ See Securities Exchange Act Release No. 53382 (February 27, 2006), 71 FR 11251... Audit Committee, Compensation Committee, and Regulatory Oversight Committee May 4, 2010. Pursuant to... eliminate its audit committee (the ``NYSE Arca Audit Committee''), its compensation committee (the......

  2. Climate Change Impacts on the Built Environment in the United States and Implications for Sustainability

    Science.gov (United States)

    Quattrochi, Dale A.

    2012-01-01

    As an integral part of the National Climate Assessment (NCA), technical assessment reports for 13 regions in the U.S. that describe the scientific rationale to support climate change impacts within the purview of these regions, and provide adaptation or mitigation measures in response to these impacts. These technical assessments focus on climate change impacts on sectors that are important environmental, biophysical, and social and economic aspects of sustainability within the U.S.: Climate change science, Ecosystems and biodiversity, Water resources, Human health, Energy supply and use, Water/energy/land use, Transportation, Urban/infrastructure/vulnerability, Agriculture, Impacts of climate change on tribal/indigenous and native lands and resources, Forestry, Land use/land cover change, Rural communities development, and Impacts on biogeochemical cycles, with implications for ecosystems and biodiversity. There is a critical and timely need for the development of mitigation and adaptation strategies in response to climate change by the policy and decision making communities, to insure resiliency and sustainability of the built environment in the future.

  3. Pancreatic B-cell behaviour after changing the natural environment of sand rats (Psammomys obesus.

    Science.gov (United States)

    Hahn, H J; Jutzi, E; Köhler, E; Schäfer, H

    1976-01-01

    On the basis of the blood glucose increase during the capitivity sand rats born in the desert were classified as normals, protodiabetics and diabetics, indicating a different adaptation to the new environment within a definite period. Isolated islets of animals, which did not develop a hyperglycemia, enhanced their insulin content during the adaptation period. The absolute insulin secretion rates in response to 16.5 mM glucose were rather similar between the three investigated groups and not modified by the insulin as well as glucagon content of pancreatic islets. But, since islets of hyperglycemic sand rats could not increase the insulin content, a significantly enhanced fractional secretion (as % of the content) could be observed. The results let us assume that the B-cell reaction during the adaptation period can be modified by further factors additionally to the changed environment. PMID:795642

  4. The future of marketing: an appropriate response to the environment changes

    Directory of Open Access Journals (Sweden)

    Victor DANCIU

    2013-05-01

    Full Text Available The future landscape of the business worldwide will have the marketing evolutions as a driver. These evolutions will be the response to the changes of business and marketing environment.The paper aims to analyze both the key trends that are shaping the macro environment, markets and consumers and their impact on the marketing at business level. First, these issues are presented as they result of both theoretical and applied various researches performed by numerous international and national organizations, universities, consulting and global companies, scholars and authors. These researches are read from the author’s scientific point of view, on the other hand, and some own considerations are revealed. They could be found mainly in the systematic approach by using the marketing paradigm and practices around the world, in order to keep successful the organizations. These organizations should give the proper skillful response to each of main futures challenges of marketing.

  5. Integrated assessment and changes of ecological environment in the Daning River Watershed

    Institute of Scientific and Technical Information of China (English)

    LIU Ruimin; SHEN Zhenyao

    2007-01-01

    Based on Remote Sensing (RS),Geographical Information Systems (GIS),and the Spatial Principal Component Analysis (SPCA) method,the integrated assessment and changes in the ecological environment of Daning River Watershed are studied in this paper.The watershed is located in the Three Gorge Area in China.The result of the integrated assessment showed that level 9 had the biggest proportion in the year 1990,which was about 40%.In the year 2000,however,there were no levels with a proportion significantly bigger than the others.By comparing the assessment results in 1990 and 2000,it is discovered that the ecological environment in Daning River Watershed in 1990 was better than that in 2000.

  6. Robust online belief space planning in changing environments: Application to physical mobile robots

    KAUST Repository

    Agha-mohammadi, Ali-akbar

    2014-05-01

    © 2014 IEEE. Motion planning in belief space (under motion and sensing uncertainty) is a challenging problem due to the computational intractability of its exact solution. The Feedback-based Information RoadMap (FIRM) framework made an important theoretical step toward enabling roadmap-based planning in belief space and provided a computationally tractable version of belief space planning. However, there are still challenges in applying belief space planners to physical systems, such as the discrepancy between computational models and real physical models. In this paper, we propose a dynamic replanning scheme in belief space to address such challenges. Moreover, we present techniques to cope with changes in the environment (e.g., changes in the obstacle map), as well as unforeseen large deviations in the robot\\'s location (e.g., the kidnapped robot problem). We then utilize these techniques to implement the first online replanning scheme in belief space on a physical mobile robot that is robust to changes in the environment and large disturbances. This method demonstrates that belief space planning is a practical tool for robot motion planning.

  7. Joint imaging and change detection for robust exploitation in interrupted SAR environments

    Science.gov (United States)

    Ash, Joshua N.

    2013-05-01

    Modern radar systems equipped with agile-beam technology support multiple modes of operation, including, for example, tracking, automated target recognition (ATR), and synthetic aperture radar imaging (SAR). In a multimode operating environment, the services compete for radar resources and leave gaps in the coherent collection aperture devoted to SAR imaging. Such gapped collections, referred to as interrupted SAR, typically result in significant image distortion and can substantially degrade subsequent exploitation tasks, such as change detection. In this work we present a new form of exploitation that jointly performs imaging and coherent change detection in interrupted environments. We adopt a Bayesian approach that inherently accommodates different interrupt patterns and compensates for missing data via exploitation of 1) a partially coherent model for reference-pass to mission-pass pixel transitions, and 2) the a priori notion that changes between passes are generally sparse and spatially clustered. We employ approximate message passing for computationally efficient Bayesian inference and demonstrate performance on measured and synthetic SAR data. The results demonstrate near optimal (ungapped) performance with pulse loss rates up to ˜ 50% and highlight orders of magnitude reduction in false alarm rates compared to traditional methods.

  8. The Analysis of Moonborne Cross Track Synthetic Aperture Radar Interferometry for Global Environment Change Monitoring

    International Nuclear Information System (INIS)

    Faced to the earth observation requirement of large scale global environment change, a SAR (Synthetic Aperture Radar) antenna system is proposed to set on Moon's surface for interferometry in this paper. With several advantages superior to low earth obit SAR, such as high space resolution, large range swath and short revisit interval, the moonborne SAR could be a potential data resource of global changes monitoring and environment change research. Due to the high stability and ease of maintenance, the novel system is competent for offering a long and continuous time series of remote sensing imagery. The Moonborne SAR system performance is discussed at the beginning. Then, the peculiarity of interferometry is analyzed in both repeat pass and single pass cases. The chief distinguishing feature which is worth to research the potentiality of repeat pass interferometry is that the revisit interval is reduced to one day in most cases, and in worst case one month. Decorrelation deriving from geometry variety is discussed in detail. It turns out that the feasibility of moonborne SAR repeat pass interferometry depends on the declination of Moon. The severity of shift effects in radar echoes increased as Moon approaches to the equatorial plane. Moreover, referring to the single pass interferometry, two antennas are assumed to set on different latitude of Moon. There is enough space on Moon to form a long baseline, which is highly related to the interferogram precision

  9. Changing the environment to improve population health: a framework for considering exposure in natural experimental studies.

    Science.gov (United States)

    Humphreys, David K; Panter, Jenna; Sahlqvist, Shannon; Goodman, Anna; Ogilvie, David

    2016-09-01

    There is renewed optimism regarding the use of natural experimental studies to generate evidence as to the effectiveness of population health interventions. Natural experimental studies capitalise on environmental and policy events that alter exposure to certain social, economic or environmental factors that influence health. Natural experimental studies can be useful for examining the impact of changes to 'upstream' determinants, which may not be amenable to controlled experiments. However, while natural experiments provide opportunities to generate evidence, they often present certain conceptual and methodological obstacles. Population health interventions that alter the physical or social environment are usually administered broadly across populations and communities. The breadth of these interventions means that variation in exposure, uptake and impact may be complex. Yet many evaluations of natural experiments focus narrowly on identifying suitable 'exposed' and 'unexposed' populations for comparison. In this paper, we discuss conceptual and analytical issues relating to defining and measuring exposure to interventions in this context, including how recent advances in technology may enable researchers to better understand the nature of population exposure to changes in the built environment. We argue that when it is unclear whether populations are exposed to an intervention, it may be advantageous to supplement traditional impact assessments with observational approaches that investigate differing levels of exposure. We suggest that an improved understanding of changes in exposure will assist the investigation of the impact of complex natural experiments in population health. PMID:27056683

  10. ECO-ENVIRONMENT CHANGE AND SOIL EROSION PROCESS IN THE RECLAIMED FORESTLAND OF THE LOESS PLATEAU

    Institute of Scientific and Technical Information of China (English)

    ZHA Xiao-chun; TANG Ke-li

    2003-01-01

    Serious soil erosion has made the eco-environment fragile in the Loess Plateau. Based on the 10-year da-ta observed from 1989 to 1998 in the Ziwuling Survey Station in loess hilly region, the eco-environment change and soil erosion process in reclaimed forestland were studied in this paper. The results showed that the intensity of man-made soil erosion caused by forestland reclamation was 1000 times more than that of the natural erosion. From the analysis of soil physical and mechanical properties, in the 10th year after forestland was reclaimed, the clay content and physical clay content decreased 2.74 percentage point and 3.01 percentage point respectively, the >0.25mm water-stable aggregate content decreased 31.59 percentage point, the soil bulk density increased and soil shear strength de-creased, all of which were easier to cause soil erosion. The correlation analysis showed that >0.25mm waterstable ag-gregate content was the key factor affecting soil erosion, and the secondary factors were soil coarse grain and soil shear strength. The relation between the >0.25mm waterstable aggregate content, the soil sheer strength and the soil erosion intensity were analyzed, which showed that the first year and the seventh erosion year were the turn years of the soil erosion intensity after the forestland was reclaimed, revealed that the change ofeco-environment was the main cause to accelerate soil erosion, and the worse environment caused soil erosion to be serious rapidly.

  11. Potential Climate Change Impacts on the Built Environment in the United States and Implications for Sustainability

    Science.gov (United States)

    Quattrochi, D.

    2012-12-01

    The built environment consists of components that have been made by humans at a range of scales from small (e.g., houses, shopping malls) to large (e.g., transportation networks) to highly modified landscapes such as cities. The impacts of climate change on the built environment, therefore, may have a multitude of effects on humans and the land. The impact of climate change may be exacerbated by the interaction of different events that singly may be minor, but together may have a synergistic set of impacts that are significant. Also, there may be feedback mechanisms wherein the built environment, particularly in the form of cities, may affect weather and the climate on local and regional scales. Besides having a host of such interactions, the impacts of climate change on urban areas will likely have thresholds, below which effects are incidental or of mild consequence, but beyond which the effects quickly become major. Hence, a city may be able to cope with prolonged heat waves, but if this is combined with severe drought, the overall result could be significant or even catastrophic, as accelerating demand for energy to cooling taxes water supplies needed both for energy supply and municipal water needs. Moreover, urban areas may be affected by changes in daily and seasonal high or low temperatures or precipitation, which may have a much more prolonged impact than the direct effect of these events. Thus, the cumulative impacts of multiple events may be more severe than those of any single event. Primary hazards include sea level rise and coastal storms, heat waves, intense precipitation, drought, extreme wind events, urban heat islands, and secondary air pollutants, and cold air events including frozen precipitation. Indicators need to be developed to provide a consistent, objective, and transparent overview of major variations in climate impacts, vulnerabilities, adaptation, and mitigation activities. Overall, indicators of climate change on the built environment

  12. Beijing eco-environment information platform and land use/cover change service construction

    Science.gov (United States)

    Zhao, Chunjiang; Wang, Yuansheng; Wang, Jihua; Feng, Zhongke; Hu, Xiaoyan; Zhou, Weiru

    2009-06-01

    The application of eco-environment information management and the Land Use and Cover Change (LUCC) models in system construction and data processing has formed a comparative matured system, but coupling using of them in the information service system construction of eco-environment has not been thoroughly investigated. At present, the management decision-making of the eco-environment urgently needs a kind of integrated, efficient and practical technology to achieve intensive management. Because the eco-environment resources characterized by the broad distribution and the complex structure, the 3S (GPS, GIS and RS) and other key technologies must be relied on to achieve the targets of "automatic, efficient, informational and precise". In this paper, an information platform was designed systematically according to the needs of dynamic monitoring and information management for ecoenvironment using J2EE technology, WebGIS technology integrated with traditional MIS/OA seamlessly, by means of spatial database, 3S integration technology, three-dimensional virtual simulation, computer network technology, etc. A database of urban infrastructure was established, and the LUCC model service technology was embedded into the platform for its significance on the eco-environment. This system can automatically analyze and classify different dates of RS image data with the ability to dynamically export the LUCC maps, and to synchronously update the information resources and network database. Results show that this system enhances the awareness as well as ability of analyzing and forecasting the dynamic process of LUCC so as to provide a macro decision-making basis for the relevant departments.

  13. Changes in body fluids of the cocooning fossorial frog Cyclorana australis in a seasonally dry environment.

    Science.gov (United States)

    Reynolds, Stephen J; Christian, Keith A; Tracy, Christopher R; Hutley, Lindsay B

    2011-11-01

    We investigated changes in the lymph (equivalent to plasma) and urine of the cocooning frog Cyclorana australis during the dry season in monsoonal northern Australia. Frogs in moist soil for two days were fully hydrated (lymph 220 mOsm kg(-1), urine 49 mOsm kg(-1)). From five weeks onwards the soil was dry (matric potential soil, osmolality increase in C. australis was not severe. Aestivation in a cocoon facilitates survival in shallow burrows, but such a strategy may only be effective in environments with seasonally reliable rainfall. PMID:21777688

  14. Comparative assessment of health environment and climate change from coal and nuclear energy-chain

    International Nuclear Information System (INIS)

    This paper describes the health, environment impact and climate change from coal and nuclear energy-chain in China. The health impact from nuclear energy-chain is less than 3-4 Orders from coal energy chain. The radiological impact from nuclear energy chain is also less than 1-2 orders. the release airborne effluents from coal energy chain have become main sources of air pollution. The development of nuclear energy is one of the real way to decrease pollution, of cause, it is important to increase the efficiency of energy conversion and to decrease the release effluents

  15. Capacity building in complex environments: seeking meaningful methodology for social change

    OpenAIRE

    Ortiz, Alfredo

    2013-01-01

    This dissertation explores ways in which “capacity-building” might contribute to processes of social change in complex environments. This exploration emerged as part of a personal journey as a capacity-building practitioner to help make sense out of my prior work experience. In my experience, I learned first-hand how many of the “capacity” challenges that my colleagues and I were trying to address in different organizations were complex, “messy” and uncertain. At the same time, many of the ca...

  16. Welfare Mix and Hybridity. Flexible Adjustments to Changed Environments. Introduction to the Special Issue

    DEFF Research Database (Denmark)

    Henriksen, Lars Skov; Smith, Steven Rathgeb; Zimmer, Annette

    2015-01-01

    Present day welfare societies rely on a complex mix of different providers ranging from the state, markets, family, and non-profit organizations to unions, grassroots organizations, and informal networks. At the same time changing welfare discourses have opened up space for new partnerships...... organizations and organizational fields adjust to a new environment that is increasingly dominated by the logic of the market, and how in particular nonprofit organizations, as hybrids by definition, are able to cope with new demands, funding structures, and control mechanisms....

  17. Investigating Artificial Immune Systems For Job Shop Rescheduling In Changing Environments

    CERN Document Server

    Uwe, Aickelin; Aniza, Din

    2008-01-01

    Artificial immune system can be used to generate schedules in changing environments and it has been proven to be more robust than schedules developed using a genetic algorithm. Good schedules can be produced especially when the number of the antigens is increased. However, an increase in the range of the antigens had somehow affected the fitness of the immune system. In this research, we are trying to improve the result of the system by rescheduling the same problem using the same method while at the same time maintaining the robustness of the schedules.

  18. Mitochondrial Plasticity With Exercise Training and Extreme Environments

    DEFF Research Database (Denmark)

    Boushel, Robert; Lundby, Carsten; Qvortrup, Klaus;

    2014-01-01

    Mitochondria form a reticulum in skeletal muscle. Exercise training stimulates mitochondrial biogenesis, yet an emerging hypothesis is that training also induces qualitative regulatory changes. Substrate oxidation, oxygen affinity and biochemical coupling efficiency may be differentially regulated...... with training and exposure to extreme environments. Threshold training doses inducing mitochondrial up-regulation remain to be elucidated considering fitness level. SUMMARY: Muscle mitochondrial are responsive to training and environment, yet thresholds for volume vs. regulatory changes and their...

  19. A life-history perspective on the demographic drivers of structured population dynamics in changing environments.

    Science.gov (United States)

    Koons, David N; Iles, David T; Schaub, Michael; Caswell, Hal

    2016-09-01

    Current understanding of life-history evolution and how demographic parameters contribute to population dynamics across species is largely based on assumptions of either constant environments or stationary environmental variation. Meanwhile, species are faced with non-stationary environmental conditions (changing mean, variance, or both) created by climate and landscape change. To close the gap between contemporary reality and demographic theory, we develop a set of transient life table response experiments (LTREs) for decomposing realised population growth rates into contributions from specific vital rates and components of population structure. Using transient LTREs in a theoretical framework, we reveal that established concepts in population biology will require revision because of reliance on approaches that do not address the influence of unstable population structure on population growth and mean fitness. Going forward, transient LTREs will enhance understanding of demography and improve the explanatory power of models used to understand ecological and evolutionary dynamics. PMID:27401966

  20. Crowded, cell-like environment induces shape changes in aspherical protein

    Science.gov (United States)

    Cheung, Margaret

    2009-03-01

    How the crowded environment inside cells affects the structures of proteins with aspherical shapes is a vital question because many proteins and protein--protein complexes in vivo adopt anisotropic shapes. Here we address this question by combining computational and experimental studies of a football-shaped protein (i.e. Borrelia burgdorferi VlsE) under crowded, cell-like conditions. The results show that macromolecular crowding affects protein-folding dynamics as well as overall protein shape. In crowded milieus, distinct conformational changes in VlsE are accompanied by secondary structure alterations that lead to exposure of a hidden antigenic region. Our work demonstrates the malleability of ``native'' proteins and implies that crowding-induced shape changes may be important for protein function and malfunction in vivo.

  1. Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments.

    Science.gov (United States)

    Inoue, S; Frank, V; Hörning, M; Kaufmann, S; Yoshikawa, H Y; Madsen, J P; Lewis, A L; Armes, S P; Tanaka, M

    2015-12-01

    With the aid of stimulus-responsive hydrogel substrates composed of ABA triblock copolymer micelles, we monitored the morphological dynamics of myoblast (C2C12) cells in response to an abrupt change in the substrate elasticity by live cell imaging. The remodeling of actin cytoskeletons could be monitored by means of transient transfection with LifeAct-GFP. Dynamic changes in the orientational order of actin filaments were characterized by an order parameter, which enables one to generalize the mechanically induced actin cytoskeletons as a break of symmetry. The critical role that acto-myosin complexes play in the morphological transition was verified by the treatment of cells with myosin II inhibitor (blebbistatin) and the fluorescence localization of focal adhesion contacts. Such dynamically tunable hydrogels can be utilized as in vitro cellular micro-environments that can exert time-dependent stimuli to mechanically regulate target cells. PMID:26347909

  2. Teenager at the life crossroads: socialization, analysis of the factors of developmental environment change

    Directory of Open Access Journals (Sweden)

    K.D. Hlomov

    2014-08-01

    Full Text Available Compared with their forerunners, the modern teenagers experience adolescence and solve age problems in different way, and face other social risks. The representations of situations of social and psychological adjustment and maladjustment also differ in some aspects. The article discusses the factors which influence the adolescence in modern conditions: spread of the Internet, lack of public demand for a certain desired life trajectory of a growing teenager, high social tension and uncertainty, changes in the structure and essence of the family concept; blurred teenagers identity in the context of variety of identification options. These factors affect the development of the resources available to teenagers and their use of them, which social risks they are exposed to, and what forms of deviant behavior they show. Such changes in the social environment of adolescent development and, as a consequence, in the experiencing adolescence, allow to check and revise the existing representations of the teen age problems

  3. Physician perspectives on colorectal cancer surveillance care in a changing environment.

    Science.gov (United States)

    Zapka, Jane; Sterba, Katherine R; LaPelle, Nancy; Armeson, Kent; Burshell, Dana R; Ford, Marvella E

    2015-06-01

    The purpose of this formative qualitatively driven mixed-methods study was to refine a measurement tool for use in interventions to improve colorectal cancer (CRC) surveillance care. We employed key informant interviews to explore the attitudes, practices, and preferences of four physician specialties. A national survey, literature review, and expert consultation also informed survey development. Cognitive pretesting obtained participant feedback to improve the survey's face and content validity and reliability. Results showed that additional domains were needed to reflect contemporary interdisciplinary trends in survivorship care, evolving practice changes and current health policy. Observed dissonance in specialists' perspectives poses challenges for the development of interventions and psychometrically sound measurement. Implications for future research include need for a flexible care model with enhanced communication and role definitions among clinical specialists, improvements in surveillance at multilevels (patients, providers, and systems), and measurement tools that focus on multispecialty involvement and the changing practice and policy environment. PMID:25878188

  4. Mapping of Danish Law Related to Companies' Impact on Environment and Climate Change

    DEFF Research Database (Denmark)

    Buhmann, Karin; Østergaard, Kim; Feldthusen, Rasmus Kristian;

    2); reporting and auditing (section 3); liability and enforcement (section 4), general observations including taxation, remuneration as a climate change incentive, and marketing law (section 5); parent-subsidiary issues, including monitoring, control and duties of the company organs (section 6......This overview of Danish law related to companies’ conduct and impact on environment and climate change has been undertaken under the ‘Sustainable Companies’ project hosted at the Department of Private Law at the University of Oslo. The ‘mapping’ of national law – including in particular company law...... – in various countries forms a major part of the empirical studies undertaken under that project. The ‘mapping’ of Danish law has been undertaken according to a general structure applied by all studies under the project, and the selection of issues described in here must be understood on that background...

  5. Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

    OpenAIRE

    Vandenbon, Alexis; Standley, Daron M; Date, Hiroshi; Forrest, Alistair R.R.; Kawaji, Hideya; Rehli, Michael; Baillie, J. Kenneth; de Hoon, Michiel J.L.; Haberle, Vanja; Lassmann, Timo; Kulakovskiy, Ivan V; Lizio, Marina; Itoh, Masayoshi; Andersson, Robin; Mungall, Christopher J

    2014-01-01

    Naturally occurring regulatory T (Treg) cells, which specifically express the transcription factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-tolerance and homeostasis. By transcriptional start site cluster analysis, we assessed here how genome-wide patterns of DNA methylation or Foxp3 binding sites were associated with Treg-specific gene expression. We found that Treg-specific DNA hypomethylated regions were closely associated with Treg up-regulated transcr...

  6. Is average chain length of plant lipids a potential proxy for vegetation, environment and climate changes?

    Science.gov (United States)

    Wang, M.; Zhang, W.; Hou, J.

    2015-04-01

    Average chain length (ACL) of leaf wax components preserved in lacustrine sediments and soil profiles has been widely adopted as a proxy indicator for past changes in vegetation, environment and climate during the late Quaternary. The fundamental assumption is that woody plants produce leaf waxes with shorter ACL values than non-woody plants. However, there is a lack of systematic survey of modern plants to justify the assumption. Here, we investigated various types of plants at two lakes, Blood Pond in the northeastern USA and Lake Ranwu on the southeastern Tibetan Plateau, and found that the ACL values were not significantly different between woody and non-woody plants. We also compiled the ACL values of modern plants in the literatures and performed a meta-analysis to determine whether a significant difference exists between woody and non-woody plants at single sites. The results showed that the ACL values of plants at 19 out of 26 sites did not show a significant difference between the two major types of plants. This suggests that extreme caution should be taken in using ACL as proxy for past changes in vegetation, environment and climate.

  7. Is average chain length of plant lipids a potential proxy for vegetation, environment and climate changes?

    Directory of Open Access Journals (Sweden)

    M. Wang

    2015-04-01

    Full Text Available Average chain length (ACL of leaf wax components preserved in lacustrine sediments and soil profiles has been widely adopted as a proxy indicator for past changes in vegetation, environment and climate during the late Quaternary. The fundamental assumption is that woody plants produce leaf waxes with shorter ACL values than non-woody plants. However, there is a lack of systematic survey of modern plants to justify the assumption. Here, we investigated various types of plants at two lakes, Blood Pond in the northeastern USA and Lake Ranwu on the southeastern Tibetan Plateau, and found that the ACL values were not significantly different between woody and non-woody plants. We also compiled the ACL values of modern plants in the literatures and performed a meta-analysis to determine whether a significant difference exists between woody and non-woody plants at single sites. The results showed that the ACL values of plants at 19 out of 26 sites did not show a significant difference between the two major types of plants. This suggests that extreme caution should be taken in using ACL as proxy for past changes in vegetation, environment and climate.

  8. Change of water environment in the inner bay in consideration of heat balance

    International Nuclear Information System (INIS)

    The study on the effect of warm water discharged from large capacity thermal and nuclear power stations on the local climate around the power stations is necessary for promoting the development of power resources in harmony with natural environment. In this study, Mikawa Bay was selected as the object of research, and the simulation analysis of water temperature was carried out by the water column model, based on the result of analysis of the local weather and sea observation data. Thus, the amount of heat exchange between the atmosphere and sea water in natural sea area was grasped, and how the change in the amount of heat exchange when the thermal load due to warm water discharge was imposed is ranked in natural sea environment was examined. The variation of surface water temperature in Mikawa Bay tended to be large in summer and small in winter. It was clarified that the factor controlling the water temperature in the bay was the variation of climatic factors. In the sea area where the effect of open sea water was relatively small, the variation of water temperature was able to be expressed by the water column model. The change in the amount of heat exchange in the range of warm water diffusion with 2 deg C temperature rise was determined. (Kato, I.)

  9. Staged cost optimization of urban storm drainage systems based on hydraulic performance in a changing environment

    Directory of Open Access Journals (Sweden)

    M. Maharjan

    2009-04-01

    Full Text Available Urban flooding causes large economic losses, property damage and loss of lives. The impact of environmental changes, mainly urbanization and climatic change, leads to increased runoff and peak flows which the drainage system must be able to cope with to reduce potential damage and inconvenience. Allowing for detention storage to compliment the conveyance capacity of the drainage system network is one of the approaches to reduce urban floods. Contemporary practice is to design systems against stationary environmental forcings – including design rainfall, landuse, etc. Due to the rapid change in the climate- and the urban environment, this approach is no longer appropriate, and explicit consideration of gradual changes during the life-time of the drainage system is warranted. In this paper, a staged cost optimization tool based on the hydraulic performance of the drainage system is presented. A one dimensional hydraulic model is used for hydraulic evaluation of the network together with a genetic algorithm based optimization tool to determine optimal intervention timings and responses over the analysis period. The model was applied in a case study area in the city of Porto Alegre, Brazil. It was concluded that considerable financial savings and/or additional level of flood-safety can be achieved by approaching the design problem as a staged plan rather than one-off scheme.

  10. Staged cost optimization of urban storm drainage systems based on hydraulic performance in a changing environment

    Directory of Open Access Journals (Sweden)

    M. Maharjan

    2008-06-01

    Full Text Available Urban flooding causes large economic losses, property damage and loss of lives. The impact of environmental changes mainly, the urbanization and the climatic change leads to increased runoff and increased peak flows which the drainage system must be able to cope with to overcome possible damage and inconveniences caused by the induced flooding. Allowing for detention storage to compliment the capacity of the drainage system network is one of the approaches to reduce urban floods. The traditional practice was to design systems against stationary environmental forcings – including design rainfall, landuse, etc. Due to the rapid change in climate-environment, this approach is no longer economically viable and safe, and explicit consideration of changes that gradually take place during the life-time of the drainage system is warranted. In this paper, a staged cost optimization tool based on the hydraulic performance of the drainage system is presented. A one dimensional hydraulic model is used for hydraulic evaluation of the network together with a genetic algorithm based optimization tool to determine optimal intervention timings and amounts throughout the lifespan of the drainage network. The model was applied in a case study area in the city of Porto Alegre, Brazil. It was concluded that considerable financial savings and/or additional level of flood-safety can be achieved by approaching the design problem as a staged plan rather than one-off scheme.

  11. Risk evolution: how can changes in the built environment influence the potential loss of natural hazards?

    Science.gov (United States)

    Schwendtner, B.; Papathoma-Köhle, M.; Glade, T.

    2013-09-01

    Alpine areas often suffer significant loss and damage due to a range of natural processes such as landslides, debris flows, snow avalanches or floods. Sealing of the soil surface, settling in endangered areas and enhanced human intervention in the natural settings, as well as socio-economic changes, increase the risk and susceptibility of built environments to natural hazards and the costs of the consequences in a spatio-temporal context. The present study examines the loss estimation of a particular debris flow event for different points in time. The event occurred in August 1987, affected the municipality Martell in South Tyrol, Italy, and resulted in a total cost of € 25 million. The approach presented in this paper focuses on the changes of the land use and settlement expansion in the area since 1954 and attempts to assess the monetary impact of a similar event, which could have happened before (1954, 1985) or following the actual event (1992, 1999, 2006). The method applied is based on the use of a vulnerability curve which was developed for the specific area, based on the documentation of the damage of the 1987 event. Based on this curve, a loss estimation was carried out in order to visualise the risk evolution in a period of 52 yr (1954 to 2006). The results show a significant increase in the extent of the built environment (number, size and value of buildings) which consequently reflect an increase of the potential overall loss through the years. The method can be used in order to assess the potential loss for future scenarios based on different spatial patterns of the built environment.

  12. Regulatory activities

    International Nuclear Information System (INIS)

    This publication, compiled in 8 chapters, presents the regulatory system developed by the Nuclear Regulatory Authority (NRA) of the Argentine Republic. The following activities and developed topics in this document describe: the evolution of the nuclear regulatory activity in Argentina; the Argentine regulatory system; the nuclear regulatory laws and standards; the inspection and safeguards of nuclear facilities; the emergency systems; the environmental systems; the environmental monitoring; the analysis laboratories on physical and biological dosimetry, prenatal irradiation, internal irradiation, radiation measurements, detection techniques on nuclear testing, medical program on radiation protection; the institutional relations with national and international organization; the training courses and meeting; the technical information

  13. Proceedings of the workshop cum nineteenth national symposium on environment: climate change and its impact

    International Nuclear Information System (INIS)

    Climate change is now recognized as the major environmental problem facing the mankind. The impacts are being felt in the form of melting ice caps in the Polar Regions and increased variability in temperature, rainfall and storms in virtually all regions. In addition to global impacts pollution in India can also be attributed to rapid industrialization, energy production, urbanization and increase in the number of motorized vehicles. Similarly, untreated water from urban settlements and industrial activities, run off from agricultural lands carrying chemicals are primarily responsible for the deterioration of water quality and contamination of lakes, rivers and groundwater aquifers. Other environmental issues such as loss of biodiversity, land degradation and hazardous waste disposal are also a cause of concern. The continuous deterioration of environment is the result of unsustainable patterns of production and consumption processes. Actions to mitigate climate change are only possible with strong policies and technology development and appropriate pollution control measures need to be adopted to mitigate the pollutants in order to achieve a clean environment. Control of air pollution should include promotion of cleaner technologies, strengthening emission standards and monitoring systems. Water pollution control should include technological intervention to enhance effective treatment of wastewater. The discussions of the symposium covered the topics like: Climate change and mitigation strategies, air, water and soil pollution, monitoring and modeling of pollutants and their transport, aerosol characterization and health effects, environmental radioactivity including NORM, speciation studies of toxic pollutants, remote sensing - GIS studies, ecology, environmental awareness and education, bioremediation, waste management and other related areas. Papers relevant to INIS are indexed separately

  14. Structural changes of the regulatory proteins bound to the thin filaments in skeletal muscle contraction by X-ray fiber diffraction

    International Nuclear Information System (INIS)

    In order to clarify the structural changes related to the regulation mechanism in skeletal muscle contraction, the intensity changes of thin filament-based reflections were investigated by X-ray fiber diffraction. The time course and extent of intensity changes of the first to third order troponin (TN)-associated meridional reflections with a basic repeat of 38.4 nm were different for each of these reflections. The intensity of the first and second thin filament layer lines changed in a reciprocal manner both during initial activation and during the force generation process. The axial spacings of the TN-meridional reflections decreased by ∼0.1% upon activation relative to the relaxing state and increased by ∼0.24% in the force generation state, in line with that of the 2.7-nm reflection. Ca2+-binding to TN triggered the shortening and a change in the helical symmetry of the thin filaments. Modeling of the structural changes using the intensities of the thin filament-based reflections suggested that the conformation of the globular core domain of TN altered upon activation, undergoing additional conformational changes at the tension plateau. The tail domain of TN moved together with tropomyosin during contraction. The results indicate that the structural changes of regulatory proteins bound to the actin filaments occur in two steps, the first in response to the Ca2+-binding and the second induced by actomyosin interaction

  15. Learning and assessment credibility: The design of examination strategies in a changing learning environment

    Directory of Open Access Journals (Sweden)

    Michael Diprose

    2013-03-01

    Full Text Available Learning environments for higher education have changed considerably in the last 20 years, especially since the advent of the internet. In addition to the change in learning technologies has come an increasing politicisation of higher education and in the UK a change from being virtually free in the 1980s to one where annual costs (Sheffield Press Release, 2012 can now be in excess of £9000 p.a. Since there are various routes to attaining higher education and commercialisation and competition are being introduced, the output of the systems, i.e. a student’s learning, is a factor which needs very careful attention and a moderating system is required, external to the educational providers, to ensure even quality. This should test a candidate’s learning, not the educational process. Academic skills are one measure of a candidate, but other qualities are often sought by employers, such as flexibility and breadth of learning to ensure that a company is able to respond to new market challenges and opportunities. Traditional examinations do not always test such skills. It is suggested in this paper, that in order to accommodate the wide variety of routes to education, some candidates might register only for examinations at a university and not the course itself. In addition some ways of obtaining more information about a candidate’s abilities are suggested.

  16. Adaptation and evolution in marine environments. Vol. 2. The impacts of global change on biodiversity

    Energy Technology Data Exchange (ETDEWEB)

    Verde, Cinzia; Di Prisco, Guido (eds.) [CNR, Napoli (Italy). Inst. of Protein Biochemistry

    2013-02-01

    Offers a regionally focussed approach. Describes research on adaptive evolution. State-of-the-art content. The second volume of ''Adaptation and Evolution in Marine Environments - The Impacts of Global Change on Biodiversity'' from the series ''From Pole to Pole'' integrates the marine biology contribution of the first tome to the IPY 2007-2009, presenting overviews of organisms (from bacteria and ciliates to higher vertebrates) thriving on polar continental shelves, slopes and deep sea. The speed and extent of warming in the Arctic and in regions of Antarctica (the Peninsula, at the present) are greater than elsewhere. Changes impact several parameters, in particular the extent of sea ice; organisms, ecosystems and communities that became finely adapted to increasing cold in the course of millions of years are now becoming vulnerable, and biodiversity is threatened. Investigating evolutionary adaptations helps to foresee the impact of changes in temperate areas, highlighting the invaluable contribution of polar marine research to present and future outcomes of the IPY in the Earth system scenario.

  17. Spatiotemporal dynamics of giant panda habitat: Implications for panda conservation under a changing environment

    Science.gov (United States)

    Tuan Mu, Mao-Ning

    Under the current rapidly changing environment, effective and efficient actions for biodiversity conservation rely on detailed knowledge on the spatiotemporal dynamics of species distribution and habitat. However, inadequate spatiotemporal information on species habitat has compromised conservation effectiveness, even for one of the most endangered species on Earth, the giant panda (Ailuropoda melanoleuca). To address this information gap, the objectives of this dissertation were to: (1) develop an approach for remotely detecting the distribution of understory bamboo, the panda's staple food, across large geographic regions; (2) develop a modeling approach for monitoring panda habitat changes across space and time; (3) evaluate the effects of current conservation efforts on short-term panda habitat changes; and (4) assess the potential impacts of climate change on long-term panda habitat dynamics. Using two dominant bamboo species in Wolong Nature Reserve, China, I showed that an integration of species distribution modeling with land surface phenology obtained from high temporal resolution remotely sensed data is a promising approach for providing detailed information on understory bamboo distribution across large geographic regions. Derived from time series data acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS), eleven land surface phenology metrics successfully captured the phenological characteristics of vegetation caused by understory bamboo. In addition, a species distribution model (SDM) built using the maximum entropy modeling approach (Maxent) accurately captured the distribution of understory bamboo species across the reserve based on their phenological characteristics. I further demonstrated the usefulness of the phenology-based model for not only characterizing panda habitat across space, but also monitoring its dynamics over time. By quantitatively examining the effects of different predictor variables portraying land surface

  18. Providing more informative projections of climate change impact on plant distribution in a mountain environment

    Science.gov (United States)

    Randin, C.; Engler, R.; Pearman, P.; Vittoz, P.; Guisan, A.

    2007-12-01

    Due to their conic shape and the reduction of area with increasing elevation, mountain ecosystems were early identified as potentially very sensitive to global warming. Moreover, mountain systems may experience unprecedented rates of warming during the next century, two or three times higher than that records of the 20th century. In this context, species distribution models (SDM) have become important tools for rapid assessment of the impact of accelerated land use and climate change on the distribution plant species. In this study, we developed and tested new predictor variables for species distribution models (SDM), specific to current and future geographic projections of plant species in a mountain system, using the Western Swiss Alps as model region. Since meso- and micro-topography are relevant to explain geographic patterns of plant species in mountain environments, we assessed the effect of scale on predictor variables and geographic projections of SDM. We also developed a methodological framework of space-for-time evaluation to test the robustness of SDM when projected in a future changing climate. Finally, we used a cellular automaton to run dynamic simulations of plant migration under climate change in a mountain landscape, including realistic distance of seed dispersal. Results of future projections for the 21st century were also discussed in perspective of vegetation changes monitored during the 20th century. Overall, we showed in this study that, based on the most severe A1 climate change scenario and realistic dispersal simulations of plant dispersal, species extinctions in the Western Swiss Alps could affect nearly one third (28.5%) of the 284 species modeled by 2100. With the less severe B1 scenario, only 4.6% of species are predicted to become extinct. However, even with B1, 54% (153 species) may still loose more than 80% of their initial surface. Results of monitoring of past vegetation changes suggested that plant species can react quickly to the

  19. Research on countermeasures to global environment change in the field of urban planning

    Energy Technology Data Exchange (ETDEWEB)

    Kawanaka, Takashi [Building Research Inst., Tsukuba-shi, Ibaraki (Japan)

    1993-12-31

    There are a lot of research themes in the field of urban planning and related fields as mitigation of global environment change. Main theme is reduction method of CO{sub 2} gas emission as a countermeasure against global warming. Some groups research on estimation of CO{sub 2} emission caused by construction activities both in building engineering and civil engineering and also on evaluation of countermeasures. They investigate reduction of CO{sub 2} emission by fossil fuel combustion and by building materials (cement, steel and so on) production process. But we cannot use data fitted to a spatial scale of urban planning. Many researches are focused on nation wide analysis. We, BRI, make a study of {open_quotes}Research on CO{sub 2} Emission in Urban Development and the Control Technologies{close_quotes} as will be seen later at 2. (2). There are two ways of research to reduce CO{sub 2} emission caused by daily activities to urban planning field. One is research on positive utilizing of natural environment in urban areas without depending to energy consuming artificial facilities. There is a research on mitigation of heat island phenomenon for instance. The other ways are research on improvement of energy consumption effect and on reusing of wasted energy In energy consuming type urban space for instance. There s a research on promoting District Heating and Cooling (DHC) and cogeneration.

  20. Genetic and demographic parameters determining population persistence after a discrete change in the environment.

    Science.gov (United States)

    Boulding, E G; Hay, T

    2001-03-01

    Field studies suggest that populations often go extinct following discrete changes in the environment. However, populations may avoid extinction by rapidly adapting to their altered environment. We used a stochastic finite-locus model to estimate the distance the optimal value of a quantitative trait could shift in a single step Delta theta(c) without causing more than 5% of the replicate populations to go extinct. We found that evolution increased the magnitude of Delta theta(c) by at least two phenotypic standard deviations and that such evolution could take place within 5--10 generations. Indeed (Delta theta(c))(2) increased approximately linearly with the logarithm of the initial population size and the rate of this increase was much greater when heritability was high or when stabilizing selection was weak. (Delta theta(c))(2) also increased approximately linearly with the logarithm of per capita fecundity. To our surprise there was no 'demographic rescue' effect from migration; a population augmented with migrants from a neighbouring population where environmental conditions were unchanged was always more likely to go extinct. The addition of mutation, more loci, density-dependence, or environmental stochasticity had only small effects on the outcome. We were able to compare our results for closed populations with density-independent population growth to those from an analytical model and found good agreement so long as the proportion of the offspring surviving selection in the initial generations was at least 1%. PMID:11488968

  1. Exploring the use of knowledge management practices in an academic library in a changing information environment

    Directory of Open Access Journals (Sweden)

    Judith Mavodza

    2011-01-01

    Full Text Available Some academic libraries have significantly developed and are applying some knowledge management (KM principles and practices in the provision of library services. KM has been implemented in commercial and business environments towards achieving operational advantages. Its principles and tools can help libraries to improve performance and fulfil their mandate. By using a case study approach, the objective of this research was to find out how knowledge is identified, captured, shared and retained in order to enhance performance and improve the quality of service in the Metropolitan College of New York (MCNY library. A web-based questionnaire, some institutional documents, observation and face-toface interviews were used to collect data. Data was analysed both quantitatively and qualitatively. The findings indicate that the MCNY library practices are not deliberately informed by KM principles, but are amenable to KM principles. It is recommended that KM, with its potential to turn individual knowledge into organisational knowledge, should be used in positioning the MCNY library in a changing information environment.

  2. Minor Allele Frequency Changes the Nature of Genotype by Environment Interactions.

    Science.gov (United States)

    Verhulst, Brad; Neale, Michael C

    2016-09-01

    In the classical twin study, phenotypic variation is often partitioned into additive genetic (A), common (C) and specific environment (E) components. From genetical theory, the outcome of genotype by environment interaction is expected to inflate A when the interacting factor is shared (i.e., C) between the members of a twin pair. We show that estimates of both A and C can be inflated. When the shared interacting factor changes the size of the difference between homozygotes' means, the expected sibling or DZ twin correlation is .5 if and only if the minor allele frequency (MAF) is .5; otherwise the expected DZ correlation is greater than this value, consistent (and confounded) with some additional effect of C. This result is considered in the light of the distribution of minor allele frequencies for polygenic traits. Also discussed is whether such interactions take place at the locus level or affect an aggregated biological structure or system. Interactions with structures or endophenotypes that result from the aggregated effects of many loci will generally emerge as part of the A estimate. PMID:27105628

  3. Whose environment?: the end of nature, climate change and the process of post-politicization

    Directory of Open Access Journals (Sweden)

    Erik Swyngedouw

    2011-12-01

    Full Text Available The paper explores how the elevation of the environmental question, in particular the problem of climate change, to a global and consensually established public concern is both a marker of and constituent force in the production of de-politicization. The paper has four parts. First, I problematize the question of Nature and the environment. Second, the case of climate change policy is presented as cause célèbre of de-politicization. The third part relates this argument to the views of political theorists who argue that the political constitution of western democracies is increasingly marked by the consolidation of post-political and post-democratic arrangements. Fourth, I discuss the climate change consensus in light of the post-political thesis. I conclude that the matter of the environment and climate change in particular, needs to be displaced onto the terrain of the properly political.Este artigo explora como a eminência da questão ambiental, particularmente da problemática das mudanças climáticas, para uma preocupação pública global e consensualmente vigente é ao mesmo tempo um marco e uma força constituinte na produção da despolitização. Este artigo tem quatro partes. Primeiro, eu problematizo a questão da natureza e do meio ambiente. Segundo, o caso das políticas de mudanças climáticas é apresentado como cause célèbre da despolitização. A terceira parte relaciona este argumento com as visões de teóricos políticos que argumentam que a constituição política das democracias ocidentais é, cada vez mais, marcada pela consolidação de arranjos pós-politicos e pós-democráticos. Na quarta parte eu discuto o consenso das mudanças climáticas à luz da tese pós-política. Eu concluo que a questão do meio ambiente e, particularmente, das mudanças climáticas precisam ser deslocadas para o terreno do propriamente político.

  4. Evolution of evolvability in gene regulatory networks.

    Directory of Open Access Journals (Sweden)

    Anton Crombach

    Full Text Available Gene regulatory networks are perhaps the most important organizational level in the cell where signals from the cell state and the outside environment are integrated in terms of activation and inhibition of genes. For the last decade, the study of such networks has been fueled by large-scale experiments and renewed attention from the theoretical field. Different models have been proposed to, for instance, investigate expression dynamics, explain the network topology we observe in bacteria and yeast, and for the analysis of evolvability and robustness of such networks. Yet how these gene regulatory networks evolve and become evolvable remains an open question. An individual-oriented evolutionary model is used to shed light on this matter. Each individual has a genome from which its gene regulatory network is derived. Mutations, such as gene duplications and deletions, alter the genome, while the resulting network determines the gene expression pattern and hence fitness. With this protocol we let a population of individuals evolve under Darwinian selection in an environment that changes through time. Our work demonstrates that long-term evolution of complex gene regulatory networks in a changing environment can lead to a striking increase in the efficiency of generating beneficial mutations. We show that the population evolves towards genotype-phenotype mappings that allow for an orchestrated network-wide change in the gene expression pattern, requiring only a few specific gene indels. The genes involved are hubs of the networks, or directly influencing the hubs. Moreover, throughout the evolutionary trajectory the networks maintain their mutational robustness. In other words, evolution in an alternating environment leads to a network that is sensitive to a small class of beneficial mutations, while the majority of mutations remain neutral: an example of evolution of evolvability.

  5. 14. Internal symposium on secular change of structural materials for nuclear energy. Secular change mechanism in light water reactor environment

    International Nuclear Information System (INIS)

    At this symposium, lectures were given on the embrittlement by neutron irradiation of LWR pressure vessel steel, the effect that neutron irradiation exerts to austenitic stainless steel becoming sensitive, the mechanism of the occurrence and development of stress corrosion cracking in the water environment of LWRs, the effect that the water environment of LWRs exerts to fatigue life, and the environment-promoted cracking in LWR environment and its forecast. Thereafter, panel discussion was held by the lecturers. In this book, the summaries of the lectures are collected. (K.I.)

  6. Climate change and its impact on public health – A review of the global environment

    Directory of Open Access Journals (Sweden)

    Stephen Ambu

    2012-07-01

    Full Text Available Climate change is a product of human actions.The extreme events such as flash floods, droughts,heat waves, earthquakes, volcano eruptions andtsunamis seen in the world today are the result ofindiscriminate human intrusion into the environment.Vulnerable countries and populations are the mostaffected by these climatic events. This places a burdenon the resources of these countries. The Kyoto Protocolis a milestone in environmental management and theimpetus created by it must be maintained by carryingout the much needed research into appropriatemitigating measures that will alleviate the climatechange impact globally. A paradigm shift is needed inaddressing the associated risks on human health to assesssocioeconomic determinants and the related impactson disease burden. Some wealthy nations emphasizeeconomic benefits and downplay sustainability goals,health and equality. However the rising cost of energyis beginning to influence their outlook towards thisissue. The implications on economics, human healthand wellbeing are implicit. In order to strike a balancebetween disadvantaged and privileged nations, manyinternational agencies are spearheading various researchagenda to improve adaptation programmes on effectsof changing climatic conditions on health. Malaysiatoo has such programmes initiated under its 5-yeardevelopment plans.

  7. Belowground carbon allocation dynamics in changing environments: insights from in situ pulse labeling studies

    Science.gov (United States)

    Bahn, M.

    2012-12-01

    Belowground carbon (C) allocation is a key process in ecosystems: it plays an important role for plant C storage, fuels root metabolism and provides substrates for soil microorganisms, with strong implications for microbial community composition and activity and thus soil organic matter turnover. Belowground C allocation has been well studied in young plants and mesocosms, and as long-term patterns in ecosystems. Much less is known on the short-term dynamics of C allocation in mature plants and ecosystems, which reflect more closely the actual processes underlying observed C allocation patterns and the mechanisms determining responses to changing environmental conditions. C allocation dynamics can best be analyzed with isotopic pulse labeling experiments, which permit a tracing of recently photo-assimilated C to carbohydrate pools, microbial communities and respiratory fluxes. This overview talk will highlight the potential and limitations of in situ isotopic tracer experiments for assessing belowground C allocation dynamics in changing environments, summarize some major recent findings and point towards emerging research questions.

  8. Ecological environment changes in Daya Bay, China, from 1982 to 2004

    Energy Technology Data Exchange (ETDEWEB)

    Wang Youshao [Key Laboratory of Tropical Marine Environmental Dynamics, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301 (China)], E-mail: yswang@scsio.ac.cn; Lou Zhiping; Sun Cuici [Key Laboratory of Tropical Marine Environmental Dynamics, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301 (China); Sun Song [Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071 (China)

    2008-11-15

    Data collected from 12 marine monitoring stations in Daya Bay from 1982 to 2004 reveal a substantial change in the ecological environment of this region. The average N/P ratio increased from 1.377 in 1985 to 49.09 in 2004. Algal species changed from 159 species of 46 genera in 1982 to 126 species of 44 genera in 2004. Major zooplankton species went from 46 species in 1983 to 36 species in 2004. The annual mean biomass of benthic animals was recorded at 123.10 g m{sup -2} in 1982 and 126.68 g m{sup -2} in 2004. Mean biomass and species of benthic animals near nuclear power plants ranged from 317.9 g m{sup -2} in 1991 to 45.24 g m{sup -2} in 2004 and from 250 species in 1991 to 177 species in 2004. A total of 12-19 species of hermatypic corals and 13 species of mangrove plants were observed in Daya Bay from 1984 to 2002.

  9. Physical and Biological Impacts of Changing Land-Uses and the Environment

    Science.gov (United States)

    English, W. R.; Pike, J. W.; Jolley, L. W.; Goddard, M. A.; Biondi, M. J.; Hur, J. M.; Powell, B. A.; Morse, J. C.

    2005-05-01

    A goal of the Changing Land Use and the Environment (CLUE) project is to characterize surface water quality impacted by land-use change in the Saluda and Reedy River watersheds of South Carolina. The CLUE project focuses on impacts common to urban development including 1. sedimentation from construction sites, 2. alteration of discharge and channel morphology due to increased impervious surfaces, 3. macroinvertebrate community response to sedimentation and habitat alteration, and 4. microbial contamination. We found that mean streambed particle size was reduced in developing areas. Stream cross-sectional areas enlarged in catchments with high percentages of impervious surfaces. Sedimentation and altered discharge resulted in the benthic macroinvertebrate community showing a general reduction in biotic integrity values and reductions in Plecoptera taxa richness. Fecal coliform levels were higher for both surface water and bottom sediments in and below urbanized areas during base flows. Levels of fecal coliform in samples collected during storm flows were significantly higher than in base flows, and were correlated with high sediment loads.

  10. Changes of the soil environment affected by fly ash dumping site of the electric power plant

    Science.gov (United States)

    Weber, Jerzy; Gwizdz, Marta; Jamroz, Elzbieta; Debicka, Magdalena; Kocowicz, Andrzej

    2014-05-01

    In this study the effect of fly ash dumping site of the electric power plant on the surrounding soil environment was investigated. The fly ash dumping site collect wastes form brown coal combustion of Belchatow electric power station, central Poland. The dumping site is surrounding by forest, where pine trees overgrow Podzols derived from loose quartz sands. The soil profiles under study were located at a distance of 50, 100, 400 and 500 m from the dumping site, while control profiles were located 8 km away from the landfill. In all horizons of soil profiles the mpain hysico-chemical and chemical properties were determined. The humic substances were extracted from ectohumus horizons by Shnitzer's method, purified using XAD resin and freeze-dried. The fulvic acids were passed through a cation exchange column and freeze-dried. Optical density, elemental composition and atomic ratios were determined in the humic and fulvic acids. Organic carbon by KMnO4 oxidation was also determined in the organic soil horizons. The fly ash from the landfill characterized by high salinity and strong alkaline reaction (pH=10), which contributed significantly to the changes of the pH values in soils horizons. The alkalization of soils adjacent to the landfill was found, which manifested in increasing of pH values in the upper soil horizons. The impact of the landfill was also noted in the changes of the soil morphology of Podzols analysed. As a result of the alkalization, Bhs horizons have been converted into a Bs horizons. Leaching of low molecular humus fraction - typical for podzolization - has been minimized as a result of pH changes caused by the impact of the landfill, and originally occurring humic substances in the Bhs horizon (present in the control profiles) have been probably transported out of the soil profile and then into the groundwater.

  11. 77 FR 73500 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Science.gov (United States)

    2012-12-10

    ...-adjusted market capitalization weighted index containing equity securities of 500 industrial, information... when the equity market is rallying rapidly. The options in the Underlying Index will be traded on... than the Reference Index in most market environments, with the exception of when the equity market...

  12. 78 FR 69167 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To...

    Science.gov (United States)

    2013-11-18

    ..., 2013), 78 FR 60357 (Oct. 1, 2013) (SR-ICC-2013-07). II. Description of the Proposed Rule Change ICC... 12, 2013. I. Introduction On September 17, 2013, ICE Clear Credit LLC (``ICC'') filed with the Securities and Exchange Commission (``Commission'') the proposed rule change SR-ICC-2013-07 pursuant...

  13. 78 FR 48732 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Changes to...

    Science.gov (United States)

    2013-08-09

    ... Organization's Statement of the Terms of the Substance of the Proposed Rule Change The Exchange proposes... Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change 1. Purpose In... Exchange Act Release Nos. 67004 (May 17, 2012), 77 FR 30581 (May 23, 2012) (SR-Phlx-2012-64)...

  14. 77 FR 77129 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing of Proposed Rule Change With...

    Science.gov (United States)

    2012-12-31

    ... the Board's compositional requirements, they will continue to ensure a diversity of representation... change also makes several other changes to provisions pertaining to the Board's compositional... the Company or any other individual having a relationship which, in the opinion of the Company's...

  15. Sediment lithostratigraphy and past changes in sedimentary environment in isolated lakes in Satakunta region

    International Nuclear Information System (INIS)

    The purpose of the present study was to investigate lacustrine sediment sections in lakes isolated from the Baltic Sea basin and appearing in Satakunta region. One of the aims was to characterize their sediment composition and structures (sediment lithostratigraphy) and to describe their past and present sedimentary environment. Altogether, 8 lakes were selected for the study based on their variable appearance and catchment environmental conditions, i.e. properties such as lake shape, size, and morphometry, as well as altitude and geology of the drainage basin. The primary research methods applied included use of ground penetrating radar, sediment coring and physical sedimentological applications. Sediment erosion, transportation and deposition (re-deposition) are significant but often slowly-appearing processes in lacustrine environment, such as the one presently studied. The rate of erosion and sediment yield depend primarily on water depth in different parts of a lake, wind and current action, and hydrological (palaeohydrological) changes. All the presently studied sediment sections were characterized by erosion and redeposition horizons. However, this is not surprising considering their isolation history from the Baltic Sea basin and current rather shallow nature. All presently studied lakes contained 2-8 meters thick section of post-glacial sediments. Being rather shallow and filled with sediments, these lakes were considered to be prone to erosion by wind and wave actions as well as sediment re-deposition. Some of the presently studied sediment sections were characterized by 10 to 50 cm thick (sandy) erosion horizons in their type-stratigraphies. However, sections were not discovered to contain massive discontinuity surfaces that would indicate fault-type sediment structures during the past 8000 years. Neither did the ground penetrating radar data show significant faults. (orig.)

  16. Population dynamics in the presence of quasispecies effects and changing environments

    Science.gov (United States)

    Forster, Robert Burke

    2006-12-01

    This thesis explores how natural selection acts on organisms such as viruses that have either highly error-prone reproduction or face variable environmental conditions or both. By modeling population dynamics under these conditions, we gain a better understanding of the selective forces at work, both in our simulations and hopefully also in real organisms. With an understanding of the important factors in natural selection we can forecast not only the immediate fate of an existing population but also in what directions such a population might evolve in the future. We demonstrate that the concept of a quasispecies is relevant to evolution in a neutral fitness landscape. Motivated by RNA viruses such as HIV, we use RNA secondary structure as our model system and find that quasispecies effects arise both rapidly and in realistically small populations. We discover that the evolutionary effects of neutral drift, punctuated equilibrium and the selection for mutational robustness extend to the concept of a quasispecies. In our study of periodic environments, we consider the tradeoffs faced by quasispecies in adapting to environmental change. We develop an analytical model to predict whether evolution favors short-term or long-term adaptation and validate our model through simulation. Our results bear directly on the population dynamics of viruses such as West Nile that alternate between two host species. More generally, we discover that a selective pressure exists under these conditions to fuse or split genes with complementary environmental functions. Lastly, we study the general effects of frequency-dependent selection on two strains competing in a periodic environment. Under very general assumptions, we prove that stable coexistence rather than extinction is the likely outcome. The population dynamics of this system may be as simple as stable equilibrium or as complex as deterministic chaos.

  17. A changing gastric environment leads to adaptation of lipopolysaccharide variants in Helicobacter pylori populations during colonization.

    Directory of Open Access Journals (Sweden)

    Anna Skoglund

    Full Text Available The human gastric pathogen Helicobacter pylori colonizes the stomachs of half of the human population, and causes development of peptic ulcer disease and gastric adenocarcinoma. H. pylori-associated chronic atrophic gastritis (ChAG with loss of the acid-producing parietal cells, is correlated with an increased risk for development of gastric adenocarcinoma. The majority of H. pylori isolates produce lipopolysaccharides (LPS decorated with human-related Lewis epitopes, which have been shown to phase-vary in response to different environmental conditions. We have characterized the adaptations of H. pylori LPS and Lewis antigen expression to varying gastric conditions; in H. pylori isolates from mice with low or high gastric pH, respectively; in 482 clinical isolates from healthy individuals and from individuals with ChAG obtained at two time points with a four-year interval between endoscopies; and finally in isolates grown at different pH in vitro. Here we show that the gastric environment can contribute to a switch in Lewis phenotype in the two experimental mouse models. The clinical isolates from different human individuals showed that intra-individual isolates varied in Lewis antigen expression although the LPS diversity was relatively stable within each individual over time. Moreover, the isolates demonstrated considerable diversity in the levels of glycosylation and in the sizes of fucosylated O-antigen chains both within and between individuals. Thus our data suggest that different LPS variants exist in the colonizing H. pylori population, which can adapt to changes in the gastric environment and provide a means to regulate the inflammatory response of the host during disease progression.

  18. Response of marine copepods to a changing tropical environment: winners, losers and implications

    Science.gov (United States)

    Chew, Li Lee

    2016-01-01

    tenuiremis was likely an introduced species. There was no significant loss in species richness of copepods despite the dramatic changes in community structure. Discussion. Sea warming and other human-induced effects such as eutrophication, acidification and coastal habitat degradation are likely the main factors that have altered copepod community structure. The large-bodied estuarine and coastal calanoid copepods are surmised to be vulnerable to eutrophication and hypoxia, while both resilient and opportunistic species are largely unaffected by, or adaptable to, degraded coastal environments and observed sea surface temperature (SST) rise. It is forecasted that SST rise with unmitigated anthropogenic impacts will further reduce large-bodied copepod species the favoured food for fish larvae with dire consequences for coastal fish production. PMID:27257540

  19. Response of marine copepods to a changing tropical environment: winners, losers and implications.

    Science.gov (United States)

    Chew, Li Lee; Chong, Ving Ching

    2016-01-01

    tenuiremis was likely an introduced species. There was no significant loss in species richness of copepods despite the dramatic changes in community structure. Discussion. Sea warming and other human-induced effects such as eutrophication, acidification and coastal habitat degradation are likely the main factors that have altered copepod community structure. The large-bodied estuarine and coastal calanoid copepods are surmised to be vulnerable to eutrophication and hypoxia, while both resilient and opportunistic species are largely unaffected by, or adaptable to, degraded coastal environments and observed sea surface temperature (SST) rise. It is forecasted that SST rise with unmitigated anthropogenic impacts will further reduce large-bodied copepod species the favoured food for fish larvae with dire consequences for coastal fish production. PMID:27257540

  20. Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

    Science.gov (United States)

    Morikawa, Hiromasa; Ohkura, Naganari; Vandenbon, Alexis; Itoh, Masayoshi; Nagao-Sato, Sayaka; Kawaji, Hideya; Lassmann, Timo; Carninci, Piero; Hayashizaki, Yoshihide; Forrest, Alistair R. R.; Standley, Daron M.; Date, Hiroshi; Sakaguchi, Shimon; Forrest, Alistair R.R.; Kawaji, Hideya; Rehli, Michael; Baillie, J. Kenneth; de Hoon, Michiel J.L.; Haberle, Vanja; Lassmann, Timo; Kulakovskiy, Ivan V.; Lizio, Marina; Itoh, Masayoshi; Andersson, Robin; Mungall, Christopher J.; Meehan, Terrence F.; Schmeier, Sebastian; Bertin, Nicolas; Jørgensen, Mette; Dimont, Emmanuel; Arner, Erik; Schmidl, Christian; Schaefer, Ulf; Medvedeva, Yulia A.; Plessy, Charles; Vitezic, Morana; Severin, Jessica; Semple, Colin A.; Ishizu, Yuri; Francescatto, Margherita; Alam, Intikhab; Albanese, Davide; Altschuler, Gabriel M.; Archer, John A.C.; Arner, Peter; Babina, Magda; Baker, Sarah; Balwierz, Piotr J.; Beckhouse, Anthony G.; Pradhan-Bhatt, Swati; Blake, Judith A.; Blumenthal, Antje; Bodega, Beatrice; Bonetti, Alessandro; Briggs, James; Brombacher, Frank; Burroughs, A. Maxwell; Califano, Andrea; Cannistraci, Carlo V.; Carbajo, Daniel; Chen, Yun; Chierici, Marco; Ciani, Yari; Clevers, Hans C.; Dalla, Emiliano; Davis, Carrie A.; Deplancke, Bart; Detmar, Michael; Diehl, Alexander D.; Dohi, Taeko; Drabløs, Finn; Edge, Albert S.B.; Edinger, Matthias; Ekwall, Karl; Endoh, Mitsuhiro; Enomoto, Hideki; Fagiolini, Michela; Fairbairn, Lynsey; Fang, Hai; Farach-Carson, Mary C.; Faulkner, Geoffrey J.; Favorov, Alexander V.; Fisher, Malcolm E.; Frith, Martin C.; Fujita, Rie; Fukuda, Shiro; Furlanello, Cesare; Furuno, Masaaki; Furusawa, Jun-ichi; Geijtenbeek, Teunis B.; Gibson, Andrew; Gingeras, Thomas; Goldowitz, Daniel; Gough, Julian; Guhl, Sven; Guler, Reto; Gustincich, Stefano; Ha, Thomas J.; Hamaguchi, Masahide; Hara, Mitsuko; Harbers, Matthias; Harshbarger, Jayson; Hasegawa, Akira; Hasegawa, Yuki; Hashimoto, Takehiro; Herlyn, Meenhard; Hitchens, Kelly J.; Sui, Shannan J. Ho; Hofmann, Oliver M.; Hoof, Ilka; Hori, Fumi; Huminiecki, Lukasz; Iida, Kei; Ikawa, Tomokatsu; Jankovic, Boris R.; Jia, Hui; Joshi, Anagha; Jurman, Giuseppe; Kaczkowski, Bogumil; Kai, Chieko; Kaida, Kaoru; Kaiho, Ai; Kajiyama, Kazuhiro; Kanamori-Katayama, Mutsumi; Kasianov, Artem S.; Kasukawa, Takeya; Katayama, Shintaro; Kato, Sachi; Kawaguchi, Shuji; Kawamoto, Hiroshi; Kawamura, Yuki I.; Kawashima, Tsugumi; Kempfle, Judith S.; Kenna, Tony J.; Kere, Juha; Khachigian, Levon M.; Kitamura, Toshio; Klinken, S. Peter; Knox, Alan J.; Kojima, Miki; Kojima, Soichi; Kondo, Naoto; Koseki, Haruhiko; Koyasu, Shigeo; Krampitz, Sarah; Kubosaki, Atsutaka; Kwon, Andrew T.; Laros, Jeroen F.J.; Lee, Weonju; Lennartsson, Andreas; Li, Kang; Lilje, Berit; Lipovich, Leonard; Mackay-sim, Alan; Manabe, Ri-ichiroh; Mar, Jessica C.; Marchand, Benoit; Mathelier, Anthony; Mejhert, Niklas; Meynert, Alison; Mizuno, Yosuke; Morais, David A. de Lima; Morikawa, Hiromasa; Morimoto, Mitsuru; Moro, Kazuyo; Motakis, Efthymios; Motohashi, Hozumi; Mummery, Christine L.; Murata, Mitsuyoshi; Nagao-Sato, Sayaka; Nakachi, Yutaka; Nakahara, Fumio; Nakamura, Toshiyuki; Nakamura, Yukio; Nakazato, Kenichi; van Nimwegen, Erik; Ninomiya, Noriko; Nishiyori, Hiromi; Noma, Shohei; Nozaki, Tadasuke; Ogishima, Soichi; Ohkura, Naganari; Ohmiya, Hiroko; Ohno, Hiroshi; Ohshima, Mitsuhiro; Okada-Hatakeyama, Mariko; Okazaki, Yasushi; Orlando, Valerio; Ovchinnikov, Dmitry A.; Pain, Arnab; Passier, Robert; Patrikakis, Margaret; Persson, Helena; Piazza, Silvano; Prendergast, James G.D.; Rackham, Owen J.L.; Ramilowski, Jordan A.; Rashid, Mamoon; Ravasi, Timothy; Rizzu, Patrizia; Roncador, Marco; Roy, Sugata; Rye, Morten B.; Saijyo, Eri; Sajantila, Antti; Saka, Akiko; Sakaguchi, Shimon; Sakai, Mizuho; Sato, Hiroki; Satoh, Hironori; Savvi, Suzana; Saxena, Alka; Schneider, Claudio; Schultes, Erik A.; Schulze-Tanzil, Gundula G.; Schwegmann, Anita; Sengstag, Thierry; Sheng, Guojun; Shimoji, Hisashi; Shimoni, Yishai; Shin, Jay W.; Simon, Christophe; Sugiyama, Daisuke; Sugiyama, Takaaki; Suzuki, Masanori; Swoboda, Rolf K.; 't Hoen, Peter A.C.; Tagami, Michihira; Takahashi, Naoko; Takai, Jun; Tanaka, Hiroshi; Tatsukawa, Hideki; Tatum, Zuotian; Thompson, Mark; Toyoda, Hiroo; Toyoda, Tetsuro; Valen, Eivind; van de Wetering, Marc; van den Berg, Linda M.; Verardo, Roberto; Vijayan, Dipti; Vorontsov, Ilya E.; Wasserman, Wyeth W.; Watanabe, Shoko; Wells, Christine A.; Winteringham, Louise N.; Wolvetang, Ernst; Wood, Emily J.; Yamaguchi, Yoko; Yamamoto, Masayuki; Yoneda, Misako; Yonekura, Yohei; Yoshida, Shigehiro; Zabierowski, Suzan E.; Zhang, Peter G.; Zhao, Xiaobei; Zucchelli, Silvia; Summers, Kim M.; Suzuki, Harukazu; Daub, Carsten O.; Kawai, Jun; Heutink, Peter; Hide, Winston; Freeman, Tom C.; Lenhard, Boris; Bajic, Vladimir B.; Taylor, Martin S.; Makeev, Vsevolod J.; Sandelin, Albin; Hume, David A.; Carninci, Piero; Hayashizaki, Yoshihide

    2014-01-01

    Naturally occurring regulatory T (Treg) cells, which specifically express the transcription factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-tolerance and homeostasis. By transcriptional start site cluster analysis, we assessed here how genome-wide patterns of DNA methylation or Foxp3 binding sites were associated with Treg-specific gene expression. We found that Treg-specific DNA hypomethylated regions were closely associated with Treg up-regulated transcriptional start site clusters, whereas Foxp3 binding regions had no significant correlation with either up- or down-regulated clusters in nonactivated Treg cells. However, in activated Treg cells, Foxp3 binding regions showed a strong correlation with down-regulated clusters. In accordance with these findings, the above two features of activation-dependent gene regulation in Treg cells tend to occur at different locations in the genome. The results collectively indicate that Treg-specific DNA hypomethylation is instrumental in gene up-regulation in steady state Treg cells, whereas Foxp3 down-regulates the expression of its target genes in activated Treg cells. Thus, the two events seem to play distinct but complementary roles in Treg-specific gene expression. PMID:24706905