WorldWideScience

Sample records for change precision guided

  1. Precision Machining Technology. Curriculum Guide.

    Science.gov (United States)

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This curriculum guide was developed from a Technical Committee Report prepared with the assistance of industry personnel and containing a Task List which is the basis of the guide. It presents competency-based program standards for courses in precision machining technology and is part of the Idaho Vocational Curriculum Guide Project, a cooperative…

  2. Study of the precision guided communication of digital television

    Science.gov (United States)

    Liu, Lun

    2012-04-01

    Along with the progress and development of the digital technology, there produced the transmission of the new media by medium of such as the network, mobile phones and the digital television, while among them digital TV has the superiority of other media. The appearance and development of digital TV will induce a profound change in the broadcasting and television industry chain. This paper started with discussing the transformation of digital television in profit model, mode of operation and mode of transmission to construct the precision-guided communication theory; And then analyzes the properties and marketing nature of the precision-guided communication to make the construction of the precision-guided communication marketing mode; And put forward the implementing of the precision-guided communication marketing strategies and concrete steps; At the end of the article the author summarized four conclusions.

  3. Precision guided parachute LDRD final report

    Energy Technology Data Exchange (ETDEWEB)

    Gilkey, J.C. [Sandia National Labs., Albuquerque, NM (United States). Aided Navigation and Remote Sensing Dept.

    1996-07-01

    This report summarizes the results of the Precision Guided Parachute LDRD, a two year program at Sandia National Laboratories which developed a Global Positioning System (GPS) guided parachute capable of autonomous flight and landings. A detailed computer model of a gliding parachute was developed for software only simulations. A hardware in-the-loop simulator was developed and used for flight package system integration and design validation. Initial parachute drop tests were conducted at Sandia`s Coyote Canyon Cable Facility, followed by a series of airdrops using Ross Aircraft`s Twin Otter at the Burris Ranch Drop Zone. Final flights demonstrated in-flight wind estimation and the capability to fly a commanded heading. In the past, the cost and logistical complexity of an initial navigation system ruled out actively guiding a parachute. The advent of the low-cost, light-weight Global Positioning System (GPS) has eliminated this barrier. By using GPS position and velocity measurements, a guided parachute can autonomously steer itself to a targeted point on the ground through the use of control drums attached to the control lanyards of the parachute. By actively correcting for drop point errors and wind drift, the guidance accuracy of this system should be on the order of GPS position errors. This would be a significant improvement over unguided airdrops which may have errors of a mile or more.

  4. Florida Vocational Program Guide for Basic Precision Machining, Precision Machining.

    Science.gov (United States)

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This program guide has been developed to provide information that will be useful to local school district and community college administrators, instructors, program advisory committee members, regional coordinating councils, and others charged with the responsibility of offering vocational education programs in Florida. It identifies the major…

  5. Arsenal of democracy in the face of change: Precision Guided Munitions (PGMs), their evolution and some economic considerations, Working Paper No. 4

    Energy Technology Data Exchange (ETDEWEB)

    Chester, C.V.

    1990-08-01

    A brief study was made of some of the forces driving the move to Precision Guided Munitions (PGMs), including the quest for military effectiveness, combat experience, and logistic compression. PGMs cost from a few hundred to a few thousand dollars per Kg but are tens to hundreds of times more effective than conventional munitions. A year's peacetime plateau production of each US PGM can be carried by a few C-5 aircraft. Surge quantities of PGMs are within US airlift capabilities, taking some of the risk out of off-shore procurement. The improving capability of antiaircraft PGMs and the escalating cost of combat aircraft (50 to 100-fold in constant dollars since WW II) may bring into question the economic viability of manned attack aircraft. The same may be true to a slightly lesser degree for heavy armored vehicles. 14 refs., 5 tabs.

  6. Change Agent Survival Guide

    Science.gov (United States)

    Dunbar, Folwell L.

    2011-01-01

    Consulting is a rough racket. Only a tarantula hair above IRS agents, meter maids and used car sales people, the profession is a prickly burr for slings and arrows. Throw in education, focus on dysfunctional schools and call oneself a "change agent," and this bad rap all but disappears. Unfortunately, though, consulting/coaching/mentoring in…

  7. Program Guide for Basic Precision Machining 8754000 (IN48.052300) and Precision Machining MTR0470 (IN48.050300).

    Science.gov (United States)

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This competency-based program guide provides course content information and procedures for secondary schools, postsecondary vocational schools, and community colleges in Florida that conduct programs in basic precision machining and precision machining. The first section is on legal authority, which applies to all vocational education programs in…

  8. Precision Agriculture: Changing the Face of Farming

    Science.gov (United States)

    Rickman, D.; Luvall, J.; Mask, P.; Shaw, J.; Kissel, D.; Sullivan, D.

    2003-01-01

    . Just a one percent increase in efficiency is a $2,000,000 change. We all depend on farmers, literally for the bread we eat. No other activity of man even has an impact on the land that farming has. If application of precision agriculture can nelp farmers manage their land better, we all may benefit.

  9. LandingNav: Terrain Guided Automated Precision Landing Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of the proposed effort is to provide a novel and innovative precision landing sensor (LandingNav) for Mars. LandingNav supports space exploration by...

  10. Precisely Controlled 2D Free-Floating Nanosheets of Amphiphilic Molecules through Frame-Guided Assembly.

    Science.gov (United States)

    Zhou, Chao; Zhang, Yiyang; Dong, Yuanchen; Wu, Fen; Wang, Dianming; Xin, Ling; Liu, Dongsheng

    2016-11-01

    2D assembly of amphiphilic molecules in aqueous solution is a challenging and intriguing topic as it is normally thermodynamically unfavorable. However, through frame-guided assembly strategy and using DNA origami as the frame, monodispersed and shape-defined nanosheets are prepared. As leading hydrophobic groups (LHGs) are anchored on the frames, amphiphilic molecules in aqueous solution are guided to assemble in the hydrophobic region. By adjusting the distribution of the LHGs, the size and shape of the assemblies can be controlled precisely.

  11. High precision ultrasonic guided wave technique for inspection of power transmission line

    Science.gov (United States)

    Cheng, Jun; Qiu, Jinhao; Ji, Hongli; Wang, Enrong; Takagi, Toshiyuki; Uchimoto, Tetsuya

    2017-01-01

    Due to the merits of high inspection speed and long detecting distance, Ultrasonic Guided Wave(UGW) method has been commonly applied to the on-line maintenance of power transmission line. However, the guided wave propagation in this structure is very complicated, leading to the unfavorable defect localization accuracy. Aiming at this situation, a high precision UGW technique for inspection of local surface defect in power transmission line is proposed. The technique is realized by adopting a novel segmental piezoelectric ring transducer and transducer mounting scheme, combining with the comprehensive characterization of wave propagation and circumferential defect positioning with multiple piezoelectric elements. Firstly, the propagation path of guided waves in the multi-wires of transmission line under the proposed technique condition is investigated experimentally. Next, the wave velocities are calculated by dispersion curves and experiment test respectively, and from comparing of the two results, the guided wave mode propagated in transmission line is confirmed to be F(1,1) mode. Finally, the axial and circumferential positioning of local defective wires in transmission line are both achieved, by using multiple piezoelectric elements to surround the stands and send elastic waves into every single wire. The proposed research can play a role of guiding the development of highly effective UGW method and detecting system for multi-wire transmission line.

  12. Design of a Remote-controlled and GPS-guided Autonomous Robot for Precision Farming

    Directory of Open Access Journals (Sweden)

    İlker Ünal

    2015-12-01

    Full Text Available Determining variations in fields is important for precision farming applications. Precision farming is used to determine, analyse, and manage factors such as temporal and spatial variability to obtain maximum profit, sustainability, and environmental protection. However, precision farming is excessively dependent on soil and plant test processes. Furthermore, test processes are time-consuming, laborious and expensive. These processes also cannot be performed quickly by humans. For these reasons, autonomous robots should be designed and developed for the detection of field variations and variable-rate applications. In this study, a remote-controlled and GPS-guided autonomous robot was designed and developed, which can be controlled via the 3G internet and is suitable for image-processing applications. The joystick is used to manually remotely control the robot movements in any direction or speed. Real-time video transmission to the remote computer can be accomplished with a camera placed on the vehicle. Navigation software was developed for steering the robot autonomously. In the results of the field test for the navigation software, it was found that the linear target point precision ranged from 10 to 12 cm and the distributed target point precision ranged from 15 to 17 cm.

  13. Computed Tomography Guided Hook-wire Precise Localization and Minimally Invasive Resection of Pulmonary Nodules

    Directory of Open Access Journals (Sweden)

    Tong WANG

    2015-11-01

    Full Text Available Background and objective Localization of pulmonary ground glass nodule is the technical difficulty of minimally invasive operation resection. The aim of this study is to evaluate the value of computed tomography (CT-guided Hook-wire precise localization in resection of pulmonary nodules by video-assisted thoracoscopic surgery (VATS as well as to discuss the necessity and feasibility of surgical resection of GGOs through a minimally invasive approach. Methods CT-guided Hook-wire precise localization and wedge resection was done on 25 cases with 26 pulmonary nodules by VATS from May 2013 to June 2015. The efficacy of localization was evaluated in terms of procedure time, VATS success rate, and associated complications of localization. Results All the 26 pulmonary nodules (6 solid nodules and 20 GGOs of 25 patients (10 males and 15 females were preoperatively detected and localized with Hook-wire under CT guidance. Nodule diameters ranged from 5 mm-20 mm (mean: 8 mm. The distance of lung lesions from the nearest pleural surfaces ranged within 5 mm-30 mm (mean: 14 mm. All resections of lesions guided by the Hook-wire were successfully performed by VATS (success rate: 100%. The mean procedure time for the CT-guided Hook-wire localization was 10 min (range: 5 min-10 min. The mean procedure time for VATS wedge resection was 20 min (range: 15 min-40 min. The mean hospital time was 4 d (range: 3 d-6 d. The major complication of CT-guided Hook-wire localization was mild pneumothorax in 4 patients, but no one needed chest tube drainage. Wedge resection was performed successfully in all cases. The dislocation of Hook-wire was found in only one patient during the operation, but the lesion was still successfully resected under VATS. Results of pathological examination of 16 mGGOs revealed 8 primary lung cancers and 8 nonspecific chronic inflammations. Results of pathological examination of 4 pGGOs revealed 1 primary lung cancers, 1 atypical adenomatous

  14. A review of treatment planning for precision image-guided photon beam pre-clinical animal radiation studies

    NARCIS (Netherlands)

    Verhaegen, Frank; van Hoof, Stefan; Granton, Patrick V; Trani, Daniela

    2014-01-01

    Recently, precision irradiators integrated with a high-resolution CT imaging device became available for pre-clinical studies. These research platforms offer significant advantages over older generations of animal irradiators in terms of precision and accuracy of image-guided radiation targeting. Th

  15. Precise image-guided irradiation of small animals: a flexible non-profit platform

    Science.gov (United States)

    Tillner, Falk; Thute, Prasad; Löck, Steffen; Dietrich, Antje; Fursov, Andriy; Haase, Robert; Lukas, Mathias; Rimarzig, Bernd; Sobiella, Manfred; Krause, Mechthild; Baumann, Michael; Bütof, Rebecca; Enghardt, Wolfgang

    2016-04-01

    Preclinical in vivo studies using small animals are essential to develop new therapeutic options in radiation oncology. Of particular interest are orthotopic tumour models, which better reflect the clinical situation in terms of growth patterns and microenvironmental parameters of the tumour as well as the interplay of tumours with the surrounding normal tissues. Such orthotopic models increase the technical demands and the complexity of preclinical studies as local irradiation with therapeutically relevant doses requires image-guided target localisation and accurate beam application. Moreover, advanced imaging techniques are needed for monitoring treatment outcome. We present a novel small animal image-guided radiation therapy (SAIGRT) system, which allows for precise and accurate, conformal irradiation and x-ray imaging of small animals. High accuracy is achieved by its robust construction, the precise movement of its components and a fast high-resolution flat-panel detector. Field forming and x-ray imaging is accomplished close to the animal resulting in a small penumbra and a high image quality. Feasibility for irradiating orthotopic models has been proven using lung tumour and glioblastoma models in mice. The SAIGRT system provides a flexible, non-profit academic research platform which can be adapted to specific experimental needs and therefore enables systematic preclinical trials in multicentre research networks.

  16. Spatial precision vs large scale uncertainties in climate change scenario

    Science.gov (United States)

    Dubrovsky, M.; Potuznikova, K.

    2009-04-01

    In assessing climate change impacts on various weather dependent processes, weather series representing changed climate are required as an input to the impact models (for example crop growth models). In producing these series, the weather generator (WG) is often employed: WG parameters are derived from the observed series and then modified using the climate change scenario, which defines changes in the relevant climatic characteristics. These scenarios use to be derived either from GCM or RCM simulations. An advantage of using RCMs (with respect to using GCMs) consists in higher spatial resolution of simulated processes and thereby in higher spatial precision of RCM-based climate change scenario. On the other hand, advantage of using GCM-based scenarios consists in larger number of available GCM simulations, which allows to better account for the uncertainty in larger-scale patterns of climate change. This contribution aims to contribute to the discussion on the usefulness of RCMs in developing the climate change scenarios. To show the significancy of high resolution RCM based spatial signal in changes in relevant climatic characteristics, this signal will be compared with the uncertainty in GCM-simulated larger scale patterns of change. The former RCM-based signal will be derived from the RCM simulations made for the PRUDENCE project, the latter GCM based uncertainty will be based on simulations from a larger number of GCMs. The results will be shown in terms of maps for a whole Europe. Acknowledgements: The study is supported by 6th FP EU research project CECILIA (no GOCE 037005) and GAAV grant agency (project IAA300420806 - "PRASCE").

  17. New real-time MR image-guided surgical robotic system for minimally invasive precision surgery

    Energy Technology Data Exchange (ETDEWEB)

    Hashizume, M.; Yasunaga, T.; Konishi, K. [Kyushu University, Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Fukuoka (Japan); Tanoue, K.; Ieiri, S. [Kyushu University Hospital, Department of Advanced Medicine and Innovative Technology, Fukuoka (Japan); Kishi, K. [Hitachi Ltd, Mechanical Engineering Research Laboratory, Hitachinaka-Shi, Ibaraki (Japan); Nakamoto, H. [Hitachi Medical Corporation, Application Development Office, Kashiwa-Shi, Chiba (Japan); Ikeda, D. [Mizuho Ikakogyo Co. Ltd, Tokyo (Japan); Sakuma, I. [The University of Tokyo, Graduate School of Engineering, Bunkyo-Ku, Tokyo (Japan); Fujie, M. [Waseda University, Graduate School of Science and Engineering, Shinjuku-Ku, Tokyo (Japan); Dohi, T. [The University of Tokyo, Graduate School of Information Science and Technology, Bunkyo-Ku, Tokyo (Japan)

    2008-04-15

    To investigate the usefulness of a newly developed magnetic resonance (MR) image-guided surgical robotic system for minimally invasive laparoscopic surgery. The system consists of MR image guidance [interactive scan control (ISC) imaging, three-dimensional (3-D) navigation, and preoperative planning], an MR-compatible operating table, and an MR-compatible master-slave surgical manipulator that can enter the MR gantry. Using this system, we performed in vivo experiments with MR image-guided laparoscopic puncture on three pigs. We used a mimic tumor made of agarose gel and with a diameter of approximately 2 cm. All procedures were successfully performed. The operator only advanced the probe along the guidance device of the manipulator, which was adjusted on the basis of the preoperative plan, and punctured the target while maintaining the operative field using robotic forceps. The position of the probe was monitored continuously with 3-D navigation and 2-D ISC images, as well as the MR-compatible laparoscope. The ISC image was updated every 4 s; no artifact was detected. A newly developed MR image-guided surgical robotic system is feasible for an operator to perform safe and precise minimally invasive procedures. (orig.)

  18. Image-guided precision manipulation of cells and nanoparticles in microfluidics

    Science.gov (United States)

    Cummins, Zachary

    Manipulation of single cells and particles is important to biology and nanotechnology. Our electrokinetic (EK) tweezers manipulate objects in simple microfluidic devices using gentle fluid and electric forces under vision-based feedback control. In this dissertation, I detail a user-friendly implementation of EK tweezers that allows users to select, position, and assemble cells and nanoparticles. This EK system was used to measure attachment forces between living breast cancer cells, trap single quantum dots with 45 nm accuracy, build nanophotonic circuits, and scan optical properties of nanowires. With a novel multi-layer microfluidic device, EK was also used to guide single microspheres along complex 3D trajectories. The schemes, software, and methods developed here can be used in many settings to precisely manipulate most visible objects, assemble objects into useful structures, and improve the function of lab-on-a-chip microfluidic systems.

  19. Precision-guided surgical navigation system using laser guidance and 3D autostereoscopic image overlay.

    Science.gov (United States)

    Liao, Hongen; Ishihara, Hirotaka; Tran, Huy Hoang; Masamune, Ken; Sakuma, Ichiro; Dohi, Takeyoshi

    2010-01-01

    This paper describes a precision-guided surgical navigation system for minimally invasive surgery. The system combines a laser guidance technique with a three-dimensional (3D) autostereoscopic image overlay technique. Images of surgical anatomic structures superimposed onto the patient are created by employing an animated imaging method called integral videography (IV), which can display geometrically accurate 3D autostereoscopic images and reproduce motion parallax without the need for special viewing or tracking devices. To improve the placement accuracy of surgical instruments, we integrated an image overlay system with a laser guidance system for alignment of the surgical instrument and better visualization of patient's internal structure. We fabricated a laser guidance device and mounted it on an IV image overlay device. Experimental evaluations showed that the system could guide a linear surgical instrument toward a target with an average error of 2.48 mm and standard deviation of 1.76 mm. Further improvement to the design of the laser guidance device and the patient-image registration procedure of the IV image overlay will make this system practical; its use would increase surgical accuracy and reduce invasiveness.

  20. A statistics-guided approach to precise characterization of nanowire morphology.

    Science.gov (United States)

    Wang, Fei; Hwang, Youngdeok; Qian, Peter Z G; Wang, Xudong

    2010-02-23

    Precise control of nanomaterial morphology is critical to the development of advanced nanodevices with various functionalities. In this paper, we developed an efficient and effective statistics-guided approach to accurately characterizing the lengths, diameters, orientations, and densities of nanowires. Our approach has been successfully tested on a zinc oxide nanowire sample grown by hydrothermal methods. This approach has three key components. First, we introduced a novel geometric model to recover the true lengths and orientations of nanowires from their projective scanning electron microscope images, where a statistical resampling method is used to mitigate the practical difficulty of relocating the same sets of nanowires at multiple projecting angles. Second, we developed a sequential uniform sampling method for efficiently acquiring representative samples in characterizing diameters and growing density. Third, we proposed a statistical imputation method to incorporate the uncertainty in the determination of nanowire diameters arising from nonspherical cross-section spinning. This approach enables precise characterization of several fundamental aspects of nanowire morphology, which served as an excellent example to overcome nanoscale characterization challenges by using novel statistical means. It might open new opportunities in advancing nanotechnology and might also lead to the standardization of nanocharacterization in many aspects.

  1. Precision Medicine and the Changing Landscape of Research Ethics.

    Science.gov (United States)

    Hammer, Marilyn J

    2016-03-01

    President Barack Obama announced the launch of the National Institutes of Health Precision Medicine Initiative® (PMI) in January 2015. Precision medicine includes the concept of individualized or personalized medicine at a more exact level through advances in science and technology, such as genetics and genomics sequencing. Although many disease processes will be investigated through the precision medicine lens for greater understanding and improved treatment responses, oncology research and translation to practice is leading the initiative's debut, referred to as the near-term focus.

  2. Precise Orbit Determination of Earth's Satellites for Climate Change Investigation

    Science.gov (United States)

    Vespe, Francesco

    The tremendous improvement of the gravity field models which we are achieving with the last Earth's satellite missions like, CHAMP, GRACE and GOCE devoted to its recovery could make feasibile the use of precise orbit determination (POD) of Earth satellites as a tool for sensing global changes of some key atmosphere parameters like refractivity and extinction. Such improvements indeed, coupled with the huge number of running Earth's satellites and combinations of their orbital parameters (namely the nodes) in a gravity field free fashion (hereafter GFF) can magnify the solar radiation pressure acting on medium earth orbit satellites :GPS, Etalon and, in near real future GALILEO and its smooth modulation through the Earth's atmosphere (penumbra). We would remind that The GFF technique is able to cancel out with "n" satellite orbital parameters the first n-1 even zonal harmonics of the gravity field. Previously it was demonstrated that the signal we want to detect could in principle emerge from the noise threshold but, more refined models of the atmosphere would be needed to perform a more subtle analysis. So we will re-compute the signal features of penumbra by applying more refined atmospheric models. The analysis will be performed by including in GFF Earth's satellites equipped with DORIS systems (Jason, Spot 2-3-4-5, ENVISAT etc.) other than those ranged with SLR and GPS. The introduction of DORIS tracked satellites indeed will allow to cancel higher and higher order of even zonal harmonics and will make still more favourable the signal to noise budget. The analysis will be performed over a time span of at least few tens of years just to enhance probable climate signatures.

  3. High Precision Topographic Mapping at Chang'E-3 Landing Site with Multi-Source Data

    Science.gov (United States)

    Liu, Y.; Liu, B.; Xu, B.; Liu, Z.; Di, K.; Zhou, J.

    2014-04-01

    Chang'e-3 (CE-3) is the first lander and rover of China following the success of Chang'e-1 and Chang'e-2 (CE-2) orbiters. High precision topographic mapping can provide detailed terrain information to ensure the safety of the rover as well as to support scientific investigations. In this research, multi-source data are co-registered into a uniform geographic framework for high precision topographic mapping at the CE-3 landing site. CE-2 CCD images with 7 m- and 1.5 m- resolutions are registered using selfcalibration bundle adjustment method with ground control points (GCPs) selected from LRO WAC mosaic map and LOLA DTM. The trajectory of CE-3 descent images are recovered using self-calibration free net bundle adjustment, and then the topographic data is rectified by absolute orientation with GCPs selected from the adjusted CE-2 DEM and DOM. Finally, these topographic data are integrated into the same geographic framework for unified, multi-scale, high precision mapping of the CE-3 landing site. Key technologies and the mapping products of this research have been used to support the surface operations of CE-3 mission.

  4. A high precision phase reconstruction algorithm for multi-laser guide stars adaptive optics

    Science.gov (United States)

    He, Bin; Hu, Li-Fa; Li, Da-Yu; Xu, Huan-Yu; Zhang, Xing-Yun; Wang, Shao-Xin; Wang, Yu-Kun; Yang, Cheng-Liang; Cao, Zhao-Liang; Mu, Quan-Quan; Lu, Xing-Hai; Xuan, Li

    2016-09-01

    Adaptive optics (AO) systems are widespread and considered as an essential part of any large aperture telescope for obtaining a high resolution imaging at present. To enlarge the imaging field of view (FOV), multi-laser guide stars (LGSs) are currently being investigated and used for the large aperture optical telescopes. LGS measurement is necessary and pivotal to obtain the cumulative phase distortion along a target in the multi-LGSs AO system. We propose a high precision phase reconstruction algorithm to estimate the phase for a target with an uncertain turbulence profile based on the interpolation. By comparing with the conventional average method, the proposed method reduces the root mean square (RMS) error from 130 nm to 85 nm with a 30% reduction for narrow FOV. We confirm that such phase reconstruction algorithm is validated for both narrow field AO and wide field AO. Project supported by the National Natural Science Foundation of China (Grant Nos. 11174274, 11174279, 61205021, 11204299, 61475152, and 61405194) and State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences.

  5. An image-guided precision proton radiation platform for preclinical in vivo research

    Science.gov (United States)

    Ford, E.; Emery, R.; Huff, D.; Narayanan, M.; Schwartz, J.; Cao, N.; Meyer, J.; Rengan, R.; Zeng, J.; Sandison, G.; Laramore, G.; Mayr, N.

    2017-01-01

    There are many unknowns in the radiobiology of proton beams and other particle beams. We describe the development and testing of an image-guided low-energy proton system optimized for radiobiological research applications. A 50 MeV proton beam from an existing cyclotron was modified to produce collimated beams (as small as 2 mm in diameter). Ionization chamber and radiochromic film measurements were performed and benchmarked with Monte Carlo simulations (TOPAS). The proton beam was aligned with a commercially-available CT image-guided x-ray irradiator device (SARRP, Xstrahl Inc.). To examine the alternative possibility of adapting a clinical proton therapy system, we performed Monte Carlo simulations of a range-shifted 100 MeV clinical beam. The proton beam exhibits a pristine Bragg Peak at a depth of 21 mm in water with a dose rate of 8.4 Gy min‑1 (3 mm depth). The energy of the incident beam can be modulated to lower energies while preserving the Bragg peak. The LET was: 2.0 keV µm‑1 (water surface), 16 keV µm‑1 (Bragg peak), 27 keV µm‑1 (10% peak dose). Alignment of the proton beam with the SARRP system isocenter was measured at 0.24 mm agreement. The width of the beam changes very little with depth. Monte Carlo-based calculations of dose using the CT image data set as input demonstrate in vivo use. Monte Carlo simulations of the modulated 100 MeV clinical proton beam show a significantly reduced Bragg peak. We demonstrate the feasibility of a proton beam integrated with a commercial x-ray image-guidance system for preclinical in vivo studies. To our knowledge this is the first description of an experimental image-guided proton beam for preclinical radiobiology research. It will enable in vivo investigations of radiobiological effects in proton beams.

  6. Changing the precision of preschoolers' approximate number system representations changes their symbolic math performance.

    Science.gov (United States)

    Wang, Jinjing Jenny; Odic, Darko; Halberda, Justin; Feigenson, Lisa

    2016-07-01

    From early in life, humans have access to an approximate number system (ANS) that supports an intuitive sense of numerical quantity. Previous work in both children and adults suggests that individual differences in the precision of ANS representations correlate with symbolic math performance. However, this work has been almost entirely correlational in nature. Here we tested for a causal link between ANS precision and symbolic math performance by asking whether a temporary modulation of ANS precision changes symbolic math performance. First, we replicated a recent finding that 5-year-old children make more precise ANS discriminations when starting with easier trials and gradually progressing to harder ones, compared with the reverse. Next, we show that this brief modulation of ANS precision influenced children's performance on a subsequent symbolic math task but not a vocabulary task. In a supplemental experiment, we present evidence that children who performed ANS discriminations in a random trial order showed intermediate performance on both the ANS task and the symbolic math task, compared with children who made ordered discriminations. Thus, our results point to a specific causal link from the ANS to symbolic math performance.

  7. Development and Preliminary Testing of a High Precision Long Stroke Slit Change Mechanism for the SPICE Instrument

    Science.gov (United States)

    Paciotti, Gabriel; Humphries, Martin; Rottmeier, Fabrice; Blecha, Luc

    2014-01-01

    In the frame of ESA's Solar Orbiter scientific mission, Almatech has been selected to design, develop and test the Slit Change Mechanism of the SPICE (SPectral Imaging of the Coronal Environment) instrument. In order to guaranty optical cleanliness level while fulfilling stringent positioning accuracies and repeatability requirements for slit positioning in the optical path of the instrument, a linear guiding system based on a double flexible blade arrangement has been selected. The four different slits to be used for the SPICE instrument resulted in a total stroke of 16.5 mm in this linear slit changer arrangement. The combination of long stroke and high precision positioning requirements has been identified as the main design challenge to be validated through breadboard models testing. This paper presents the development of SPICE's Slit Change Mechanism (SCM) and the two-step validation tests successfully performed on breadboard models of its flexible blade support system. The validation test results have demonstrated the full adequacy of the flexible blade guiding system implemented in SPICE's Slit Change Mechanism in a stand-alone configuration. Further breadboard test results, studying the influence of the compliant connection to the SCM linear actuator on an enhanced flexible guiding system design have shown significant enhancements in the positioning accuracy and repeatability of the selected flexible guiding system. Preliminary evaluation of the linear actuator design, including a detailed tolerance analyses, has shown the suitability of this satellite roller screw based mechanism for the actuation of the tested flexible guiding system and compliant connection. The presented development and preliminary testing of the high-precision long-stroke Slit Change Mechanism for the SPICE Instrument are considered fully successful such that future tests considering the full Slit Change Mechanism can be performed, with the gained confidence, directly on a

  8. A Social Science Guide for Communication on Climate Change

    Science.gov (United States)

    St John, C.; Marx, S.; Markowitz, E.

    2014-12-01

    Researchers from the Center for Research on Environmental Decisions (CRED) published "The Psychology of Climate Change Communication: A Guide for Scientists, Journalists, Educators, Political Aides, and the Interested Public" in 2009. This landmark guide provided climate change communicators a synthesis of the social science research that was pertinent to understanding how people think about climate change and how the practice could be improved. In the fall of 2014 this guide will be rereleased, with a new title, and in a partnership between CRED and ecoAmerica. The updated guide addresses how and why Americans respond in certain ways to climate change and explains how communicators can apply best practices to their own work. The guide, which includes research from a range of social science fields including psychology, anthropology, communications, and behavioral economics, is designed to be useful for experienced and novice communicators alike. Included in the guide are strategies to boost engagement, common mistakes to avoid, and best practices that organizations around the world have used to meaningfully engage individuals and groups on climate change. The proposed presentation will provide an overview of the main findings and tips from the 2014 climate change communication guide. It will provide a deeper look at a few of the key points that are crucial for increasing audience engagement with climate change including understanding how identity shapes climate change, how to lead with solutions, and how to bring the impacts of climate change close to home. It will highlight tips for motivating positive behavior change that will lead people down the path toward solutions. Finally, it will address the benefits and challenges associated with producing a communication guide and insight into synthesizing social science research findings into a usable format for a variety of audiences.

  9. Present status and future of high-precision image guided adaptive brachytherapy for cervix carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Poetter, Richard; Kirisits, Christian; Fidarova, Elena F.; Dimopoulos, Johannes C. A.; Berger, Daniel; Tanderup, Kari; Lindegaard, Jacob C. (Dept. of Radiotherapy Medical Univ. of Vienna, General Hospital Vienna, Wien (Austria))

    2008-08-15

    Introduction. Image guided adaptive brachytherapy (IGABT) for cervical cancer, using mainly MRI, is an evolving method, increasingly replacing the 2D approach based on conventional radiography. During the complex 4D chain of this procedure image-assistance is provided for disease assessment, provisional treatment planning ('pre-planning'), applicator placement and reconstruction, as well as for contouring, definitive treatment planning and quality control of dose delivery. With IGABT changes of topography adjacent to the applicator, caused by tumour regression, oedema, organ changes and dilation are identified. Thus, the CTV for IGABT is primarily based on the tumour volume at the time of BT and takes into account both time and spatial domains. IGABT requires systematic concepts for target, OAR, biological modelling, DVH analysis, and dose-volume-adaptation. Methods and Results. This report focuses on the advantages and uncertainties, dose-effect relations and clinical results of the IGABT procedure addressing the current status and future perspectives. Uncertainties during the 4D chain of IGABT are mainly related to target contouring, applicator reconstruction, as well as to inter-fraction, intra-fraction and inter-application variability, as caused by tumour response and organ changes. Different from EBRT where set-up uncertainties are compensated by adding a margin to the CTV, no margins to the lateral and anterior-posterior directions can be used for IGABT. Discussion. By 3D treatment planning for IGABT significant improvement of the DVH parameters is achieved compared to 2D library plans. In small tumours the benefit is primarily obtained by a decrease of dose to nearby OAR while in large tumours the use of supplementary interstitial techniques and optimization may double the target volume that can be treated at a therapeutic dose level. The clinical impact of IGABT could recently be demonstrated by the establishment of some correlations between

  10. The changing circumstance of atrial fibrillation - progress towards precision medicine.

    Science.gov (United States)

    Camm, A J; Savelieva, I; Potpara, T; Hindriks, G; Pison, L; Blömstrom-Lundqvist, C

    2016-05-01

    The prevalence of atrial fibrillation (AF) in the general population is between 1% and 2% in the developed world and is higher in men than in women. The arrhythmia occurs much more commonly in the elderly, and the estimated lifetime risk of developing AF is one in four for men and women aged 40 years and above. Projected data from multiple population-based studies in the USA and Europe predict a two- to threefold increase in the number of AF patients by 2060. The high lifetime risk of AF and increased longevity underscore the important public health burden posed by this arrhythmia worldwide. AF has multiple aetiologies and a broad variety of presentations. The primary pathologies underlying or promoting the occurrence of AF vary more than for any other cardiac arrhythmia, ranging from autonomic imbalance to organic heart disease and metabolic disorders, such as diabetes mellitus, metabolic syndrome, hyperthyroidism and kidney disease, and lifestyle factors such as smoking, alcohol consumption and participation in endurance sports. Biomarkers are increasingly being investigated and, together with clinical and genetic factors, will eventually lead to a clinically valuable detailed classification of AF which will also incorporate pathophysiological determinants and mechanisms of the arrhythmia. In turn, this will allow the development and application of precision medicine to this troublesome arrhythmia.

  11. The use of laser altimetry data in Chang'E-1 precision orbit determination

    Science.gov (United States)

    Chang, Sheng-Qi; Huang, Yong; Li, Pei-Jia; Hu, Xiao-Gong; Fan, Min

    2016-09-01

    Accurate altimetric measurement not only can be applied to the calculation of a topography model but also can be used to improve the quality of the orbit reconstruction in the form of crossovers. Altimetry data from the Chang'E-1 (CE-1) laser altimeter are analyzed in this paper. The differences between the crossover constraint equation in the form of height discrepancies and in the form of minimum distances are mainly discussed. The results demonstrate that the crossover constraint equation in the form of minimum distances improves the CE-1 orbit precision. The overlap orbit performance has increased ∼ 30% compared to the orbit using only tracking data. External assessment using the topography model also shows orbit improvement. The results will be helpful for recomputing ephemeris and improving the CE-1 topography model.

  12. The use of laser altimetry data in Chang'E-1 precision orbit determination

    Science.gov (United States)

    Chang, Sheng-Qi; Huang, Yong; Li, Pei-Jia; Hu, Xiao-Gong; Fan, Min

    2016-09-01

    Accurate altimetric measurement not only can be applied to the calculation of a topography model but also can be used to improve the quality of the orbit reconstruction in the form of crossovers. Altimetry data from the Chang'E-1 (CE-1) laser altimeter are analyzed in this paper. The differences between the crossover constraint equation in the form of height discrepancies and in the form of minimum distances are mainly discussed. The results demonstrate that the crossover constraint equation in the form of minimum distances improves the CE-1 orbit precision. The overlap orbit performance has increased ˜ 30% compared to the orbit using only tracking data. External assessment using the topography model also shows orbit improvement. The results will be helpful for recomputing ephemeris and improving the CE-1 topography model.

  13. Botanical name changes – nuisance or a quest for precision?

    Directory of Open Access Journals (Sweden)

    Bruce G. Cook

    2015-01-01

    Full Text Available To understand the need for the seemingly regular changes to plant names applied to many tropical forage species, it is necessary to be aware of the rules that govern botanical nomenclature.  The binomial naming system, first proposed in 1753, is governed by rules defined in the International Code of Nomenclature for algae, fungi and plants (ICN.  These rules have been strengthened as necessary over the years in the interest of providing practitioners with plant names that are unique for each species, and presented in an hierarchical format that shows the evolutionary relationships between plants.  This paper includes a table of name changes accepted by the USDA Germplasm Resources Information Network (GRIN for species used in tropical forage research and development over the last half century.  The need to use legitimate plant names is emphasized and suggestions are made on how practitioners might best deal with the changes.Keywords: Taxonomy, nomenclature, tropical forages.DOI: 10.17138/TGFT(334-40

  14. Portfolio Assessment: Making Connections, Guiding Change

    Science.gov (United States)

    King, Caryn M.; Patterson, Nancy G.; Stolle, Elizabeth Petroelje

    2008-01-01

    Three literacy teacher-educators chart the ways in which portfolio assessment impacted their program. They discuss the tension between the demands of national accreditation standards and faculty belief systems in more ecological approaches. They describe the processes of change that occurred programmatically and individually which continue to…

  15. DONUTS: A science frame autoguiding algorithm with sub-pixel precision, capable of guiding on defocused stars

    CERN Document Server

    McCormac, J; Skillen, I; Faedi, F; Todd, I; Watson, C A

    2013-01-01

    We present the DONUTS autoguiding algorithm, designed to fix stellar positions at the sub-pixel level for high-cadence time-series photometry, which is also capable of autoguiding on defocused stars. DONUTS was designed to calculate guide corrections from a series of science images and re-centre telescope pointing between each exposure. The algorithm has the unique ability of calculating guide corrections from under-sampled to heavily defocused point spread functions. We present the case for why such an algorithm is important for high precision photometry and give our results from off and on-sky testing. We discuss the limitations of DONUTS and the facilities where it soon will be deployed.

  16. Precision manufacture of phase-change perfluorocarbon droplets using microfluidics.

    Science.gov (United States)

    Martz, Thomas D; Sheeran, Paul S; Bardin, David; Lee, Abraham P; Dayton, Paul A

    2011-11-01

    Liquid perfluorocarbon droplets have been of interest in the medical acoustics community for use as acoustically activated particles for tissue occlusion, imaging and therapeutics. To date, methods to produce liquid perfluorocarbon droplets typically result in a polydisperse size distribution. Because the threshold of acoustic activation is a function of diameter, there would be benefit from a monodisperse population to preserve uniformity in acoustic activation parameters. Through use of a microfluidic device with flow-focusing technology, the production of droplets of perfluoropentane with a uniform size distribution is demonstrated. Stability studies indicate that these droplets are stable in storage for at least two weeks. Acoustic studies illustrate the thresholds of vaporization as a function of droplet diameter, and a logarithmic relationship is observed between acoustic pressure and vaporization threshold within the size ranges studied. Droplets of uniform size have very little variability in acoustic vaporization threshold. Results indicate that microfluidic technology can enable greater manufacturing control of phase-change perfluorocarbons for acoustic droplet vaporization applications.

  17. High-precision robotic microcontact printing (R-μCP) utilizing a vision guided selectively compliant articulated robotic arm.

    Science.gov (United States)

    McNulty, Jason D; Klann, Tyler; Sha, Jin; Salick, Max; Knight, Gavin T; Turng, Lih-Sheng; Ashton, Randolph S

    2014-06-01

    Increased realization of the spatial heterogeneity found within in vivo tissue microenvironments has prompted the desire to engineer similar complexities into in vitro culture substrates. Microcontact printing (μCP) is a versatile technique for engineering such complexities onto cell culture substrates because it permits microscale control of the relative positioning of molecules and cells over large surface areas. However, challenges associated with precisely aligning and superimposing multiple μCP steps severely limits the extent of substrate modification that can be achieved using this method. Thus, we investigated the feasibility of using a vision guided selectively compliant articulated robotic arm (SCARA) for μCP applications. SCARAs are routinely used to perform high precision, repetitive tasks in manufacturing, and even low-end models are capable of achieving microscale precision. Here, we present customization of a SCARA to execute robotic-μCP (R-μCP) onto gold-coated microscope coverslips. The system not only possesses the ability to align multiple polydimethylsiloxane (PDMS) stamps but also has the capability to do so even after the substrates have been removed, reacted to graft polymer brushes, and replaced back into the system. Plus, non-biased computerized analysis shows that the system performs such sequential patterning with <10 μm precision and accuracy, which is equivalent to the repeatability specifications of the employed SCARA model. R-μCP should facilitate the engineering of complex in vivo-like complexities onto culture substrates and their integration with microfluidic devices.

  18. Delay times of a LiDAR-guided precision sprayer control system

    Science.gov (United States)

    Accurate flow control systems in triggering sprays against detected targets are needed for precision variable-rate sprayer development. System delay times due to the laser-sensor data buffer, software operation, and hydraulic-mechanical component response were determined for a control system used fo...

  19. Differentiation and Integration: Guiding Principles for Analyzing Cognitive Change

    Science.gov (United States)

    Siegler, Robert S.; Chen, Zhe

    2008-01-01

    Differentiation and integration played large roles within classic developmental theories but have been relegated to obscurity within contemporary theories. However, they may have a useful role to play in modern theories as well, if conceptualized as guiding principles for analyzing change rather than as real-time mechanisms. In the present study,…

  20. A review of treatment planning for precision image-guided photon beam pre-clinical animal radiation studies

    Energy Technology Data Exchange (ETDEWEB)

    Verhaegen, Frank; Hoof, Stefan van; Granton, Patrick V.; Trani, Daniela [Maastricht University Medical Center (Netherlands). Dept. of Radiation Oncology (MAASTRO)

    2014-07-01

    Recently, precision irradiators integrated with a high-resolution CT imaging device became available for pre-clinical studies. These research platforms offer significant advantages over older generations of animal irradiators in terms of precision and accuracy of image-guided radiation targeting. These platforms are expected to play a significant role in defining experiments that will allow translation of research findings to the human clinical setting. In the field of radiotherapy, but also others such as neurology, the platforms create unique opportunities to explore e.g. the synergy between radiation and drugs or other agents. To fully exploit the advantages of this new technology, accurate methods are needed to plan the irradiation and to calculate the three-dimensional radiation dose distribution in the specimen. To this end, dedicated treatment planning systems are needed. In this review we will discuss specific issues for precision irradiation of small animals, we will describe the workflow of animal treatment planning, and we will examine several dose calculation algorithms (factorization, superposition-convolution, Monte Carlo simulation) used for animal irradiation with kilovolt photon beams. Issues such as dose reporting methods, photon scatter, tissue segmentation and motion will also be discussed briefly.

  1. Study on the precision of the guide control system of independent wheel

    Science.gov (United States)

    ji, Y.; Ren, L.; Li, R.; Sun, W.

    2016-09-01

    The torque ripple of permanent magnet synchronous motor vector with active control is studied in this paper. The ripple appears because of the impact of position detection and current detection, the error generated in inverter and the influence of motor ontology (magnetic chain harmonic and the cogging effect and so on). Then, the simulation dynamic model of bogie with permanent magnet synchronous motor vector control system is established with MATLAB/Simulink. The stability of bogie with steering control is studied. The relationship between the error of the motor and the precision of the control system is studied. The result shows that the existing motor does not meet the requirements of the control system.

  2. A Precision Medicine Initiative for Alzheimer's disease: the road ahead to biomarker-guided integrative disease modeling.

    Science.gov (United States)

    Hampel, H; O'Bryant, S E; Durrleman, S; Younesi, E; Rojkova, K; Escott-Price, V; Corvol, J-C; Broich, K; Dubois, B; Lista, S

    2017-04-01

    After intense scientific exploration and more than a decade of failed trials, Alzheimer's disease (AD) remains a fatal global epidemic. A traditional research and drug development paradigm continues to target heterogeneous late-stage clinically phenotyped patients with single 'magic bullet' drugs. Here, we propose that it is time for a paradigm shift towards the implementation of precision medicine (PM) for enhanced risk screening, detection, treatment, and prevention of AD. The overarching structure of how PM for AD can be achieved will be provided through the convergence of breakthrough technological advances, including big data science, systems biology, genomic sequencing, blood-based biomarkers, integrated disease modeling and P4 medicine. It is hypothesized that deconstructing AD into multiple genetic and biological subsets existing within this heterogeneous target population will provide an effective PM strategy for treating individual patients with the specific agent(s) that are likely to work best based on the specific individual biological make-up. The Alzheimer's Precision Medicine Initiative (APMI) is an international collaboration of leading interdisciplinary clinicians and scientists devoted towards the implementation of PM in Neurology, Psychiatry and Neuroscience. It is hypothesized that successful realization of PM in AD and other neurodegenerative diseases will result in breakthrough therapies, such as in oncology, with optimized safety profiles, better responder rates and treatment responses, particularly through biomarker-guided early preclinical disease-stage clinical trials.

  3. a Solution to Low Rfm Fitting Precision of Planetary Orbiter Images Caused by Exposure Time Changing

    Science.gov (United States)

    Liu, B.; Xu, B.; Di, K.; Jia, M.

    2016-06-01

    In this paper, we propose a new solution to the low RFM fitting precision caused by exposure time changing using sensor correction. First, we establish a new rigorous geometric model, with the same ephemerides, attitudes and sensor design parameters of Chang'E-2 and HRSC images, using an equal exposure time of each scan line. The original rigorous geometric model is also established. With a given height, we can establish the correspondence between the two rigorous models. Then we generate a sensor corrected image by resampling the original image using an average elevation or a digital elevation model. We found that the sensor corrected images can be used for topographic mapping which maintains almost the same precision of the original images under certain conditions. And RFM can fit rigorous geometric model of the sensor corrected image very well. Preliminary experimental results show that the RMS residual error of the RFM fitting can reach to 1/100 pixel level too. Using the proposed solution, sensors with changing exposure time can be precisely modelled by the generic RFM.

  4. SKA Engineering Change Proposal: Gridded Visibilities to Enable Precision Cosmology with Radio Weak Lensing

    CERN Document Server

    Harrison, Ian

    2015-01-01

    This document was submitted as supporting material to an Engineering Change Proposal (ECP) for the Square Kilometre Array (SKA). This ECP requests gridded visibilities as an extra imaging data product from the SKA, in order to enable bespoke analysis techniques to measure source morphologies to the accuracy necessary for precision cosmology with radio weak lensing. We also discuss the properties of an SKA weak lensing data set and potential overlaps with other cosmology science goals.

  5. Changing paradigm of cancer therapy:precision medicine by next-generation sequencing

    Institute of Scientific and Technical Information of China (English)

    Yuan Xue; William R Wilcox

    2016-01-01

    Precision medicine aims to identify the right drug, for the right patient, at the right dose, at the right time, which is particularly important in cancer therapy. Problems such as the variability of treatment response and resistance to medication have been long-standing challenges in oncology, especially for development of new medications. Solid tumors, unlike hematologic malignancies or brain tumors, are remarkably diverse in their cellular origins and developmental timing. The ability of next-generation sequencing (NGS) to analyze the comprehensive landscape of genetic alterations brings promises to diseases that have a highly complex and heterogeneous genetic composition such as cancer. Here we provide an overview of how NGS is able to facilitate precision medicine and change the paradigm of cancer therapy, especially for solid tumors, through technical advancements, molecular diagnosis, response monitoring and clinical trials.

  6. A Big Data Guide to Understanding Climate Change: The Case for Theory-Guided Data Science.

    Science.gov (United States)

    Faghmous, James H; Kumar, Vipin

    2014-09-01

    Global climate change and its impact on human life has become one of our era's greatest challenges. Despite the urgency, data science has had little impact on furthering our understanding of our planet in spite of the abundance of climate data. This is a stark contrast from other fields such as advertising or electronic commerce where big data has been a great success story. This discrepancy stems from the complex nature of climate data as well as the scientific questions climate science brings forth. This article introduces a data science audience to the challenges and opportunities to mine large climate datasets, with an emphasis on the nuanced difference between mining climate data and traditional big data approaches. We focus on data, methods, and application challenges that must be addressed in order for big data to fulfill their promise with regard to climate science applications. More importantly, we highlight research showing that solely relying on traditional big data techniques results in dubious findings, and we instead propose a theory-guided data science paradigm that uses scientific theory to constrain both the big data techniques as well as the results-interpretation process to extract accurate insight from large climate data.

  7. Age-related changes in postural control to the demands of a precision task.

    Science.gov (United States)

    Yeh, Ting-Ting; Cinelli, Michael E; Lyons, James L; Lee, Timothy D

    2015-12-01

    Optimal sensorimotor integration is needed to maintain the precision of a visuomotor postural task. Furthermore, cognitive resources have been suggested to be involved in maintaining balance, especially in older adults. This study investigated how older and younger adults differed in employing sensorimotor strategies in a dual-task situation. Older (age 65-84 years) and younger adults (age 19-30 years) performed a visually-based, postural tracking task in different body orientations (from 0° to 45°), which necessitated slightly different task goals. On some trials, participants performed a concurrent silent arithmetic task with the visuomotor tracking task. The results demonstrated that sensorimotor control declined with age. Older adults showed greater medial-lateral center of pressure variability compared to younger adults in the precision task. Younger adults displayed a trend to decrease anterior-posterior variability, but older adults exhibited an opposite trend when the body orientation changed from 0° to 45°. The addition of a dual-task situation decreased overall postural variability in both age groups. Age-related changes in postural control may degrade the flexible coordination of the sensory feedback and motor execution. This study suggested that medial-lateral stability may be more sensitive to this age-related decline and may be closely associated with postural instability and falls.

  8. The Changing World Today: Case Studies of Modernization in Japan, Kenya, and India. Teacher's Guide.

    Science.gov (United States)

    Clawson, Elmer U.; Rice, Marion J.

    This publication is a guide for teachers using "The Changing World Today," an intermediate-grade student text which examines cultural change in Japan, Kenya, and India. A major portion of the guide consists of a summary outline of the text. Discussed in the outline are descriptive characteristics, rationale, antecedent conditions,…

  9. Image-guided radiation therapy. Paradigm change in radiation therapy; Bildgestuetzte Strahlentherapie. Paradigmenwechsel in der Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Wenz, F. [Universitaetsmedizin Mannheim der Universitaet Heidelberg, Klinik fuer Strahlentherapie und Radioonkologie, Mannheim (Germany); Belka, C. [Klinikum der Ludwig-Maximilians-Universitaet, Klinik fuer Strahlentherapie und Radioonkologie, Muenchen (Germany); Reiser, M. [Klinikum der Ludwig-Maximilians-Universitaet, Institut fuer Klinische Radiologie, Muenchen (Germany); Schoenberg, S.O. [Universitaetsmedizin Mannheim der Universitaet Heidelberg, Institut fuer Klinische Radiologie und Nuklearmedizin, Mannheim (Germany)

    2012-03-15

    The introduction of image-guided radiotherapy (IGRT) has changed the workflow in radiation oncology more dramatically than any other innovation in the last decades. Imaging for treatment planning before the initiation of the radiotherapy series does not take alterations in patient anatomy and organ movement into account. The principle of IGRT is the temporal and spatial connection of imaging in the treatment position immediately before radiation treatment. The actual position and the target position are compared using cone-beam computed tomography (CT) or stereotactic ultrasound. The IGRT procedure allows a reduction of the safety margins and dose to normal tissue without an increase in risk of local recurrence. In the future the linear treatment chain in radiation oncology will be developed based on the closed-loop feedback principle. The IGRT procedure is increasingly being used especially for high precision radiotherapy, e.g. for prostate or brain tumors. (orig.) [German] Die Einfuehrung der bildgestuetzten Radiotherapie (IGRT - ''image-guided radiotherapy'') hat wie kaum eine andere Innovation die Behandlungsablaeufe in der Radioonkologie veraendert. Eine einmalige Bildgebung zur Bestrahlungsplanung vor der Behandlungsserie beruecksichtigt nicht die Aenderung der Patientengeometrie und die Organbeweglichkeit. Das Prinzip der IGRT besteht in der raeumlichen und zeitlichen Zusammenfuehrung von Bildgebung in der Bestrahlungsposition unmittelbar vor der eigentlichen Bestrahlung. Mittels Cone-beam-CT oder stereotaktischem Ultraschall wird die Ist- mit der Sollposition verglichen. Die IGRT erlaubt die Reduktion der Sicherheitssaeume und damit die Schonung des Normalgewebes, ohne das Rezidivrisiko zu erhoehen. Zukuenftig wird die lineare Behandlungskette in der Radioonkologie durch eine geschlossene, multipel rueckgekoppelte Therapieschleife ersetzt werden. Speziell bei Praezisionsbestrahlungen wie z. B. Prostata- oder Hirntumoren kommt die IGRT

  10. The Changing World Today: Cultural Change in Japan, Kenya, and India. Student Text and Student Study Guide.

    Science.gov (United States)

    Clawson, Elmer U.; Rice, Marion J.

    This student text and accompanying pupil study guide for intermediate grades examine cultural change in Japan, Kenya, and India. The unit objective is to help students examine processes of change occurring in the world today by systematically presenting cultural change concepts and illustrations in case study settings. The books provide students…

  11. Structural Integrity Evaluation of Cold Neutron Laboratory Building by Design Change of Guide Shielding Room

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Sangik; Kim, Youngki; Kim, Harkrho

    2007-06-15

    This report summarizes the results of the structural integrity evaluation for the cold neutron laboratory building by design change of guide shielding room. The design of the guide shielding room was changed by making its structure members in normal concrete (2.3 g/cc) instead of heavy concrete (3.5 g/cc) because the heavy concrete could be not supplied to meet its design specification. Therefore, it was decided that the guide shielding room is made of the normal concrete. And, the shielding performance of the normal concrete was recalculated to confirm satisfying its design specification, which is of a 9000 zone according to HANARO radiation region classification. The change makes the shielding wall thicker than existing design, and then it is caused to qualify the structural integrity evaluation of the CNLB. Finally, the structural integrity of the CNLB was re-evaluated by considering the design change of the guide shielding room.

  12. Understanding Breast Changes: A Health Guide for Women

    Science.gov (United States)

    Information on specific breast conditions and changes, including how these changes are detected, diagnosed and treated. Explains that while most breast changes are not cancer, all breast changes need to be checked by a doctor. Helps women understand the next steps after an abnormal mammogram result, and includes a list of questions to help women talk with their doctor about these issues.

  13. Survey-Guided Development: Data Based Organizational Change

    Science.gov (United States)

    1975-06-01

    Kubie has stated: Not one of these acts is in and of itself inherently abnormal. As long as it can change freely in response to changing external or...internal cues, it remains normal. It is the loss of freedom to change which marks the onset of the neurotic process ( Kubie , 1966). Organizations

  14. The Deep Change Field Guide A Personal Course to Discovering the Leader Within

    CERN Document Server

    Quinn, Robert E

    2012-01-01

    How to realize your own leadership potential Based on the bestselling book, Deep Change, The Deep Change Field Guide takes readers through the introspective journey of personal transformation. The field guide streamlines, updates, and augments the content of the original book into an interactive self-teaching course that helps readers learn how to become powerful agents of change. Learning tools include reflection questions, film assignments, and action plans that help readers think about the concepts in terms of their own situations, and identify actions to embody the concepts in their lives.

  15. Strategies for Change: A Field Guide to Social Marketing for School Health Professionals

    Science.gov (United States)

    American School Health Association (NJ3), 2004

    2004-01-01

    Strategies for Change outlines how to use social marketing strategies to influence change in the health programs in a building, district or community. Authors describe how to develop a strategy to influence district administrators, school board members, colleagues and parents. This step-by-step guide leads through the process for developing,…

  16. Secondary Agricultural Education Teachers as Agents of Change in Oklahoma and the Adoption of Precision Agriculture

    Science.gov (United States)

    Nickeson, Beth

    2013-01-01

    Research indicates that precision agricultural education (PAE) in Oklahoma affects environmental quality, water conservation, and crop yields. The purpose of this mixed methods study was to explore the nature and perceived effectiveness of PAE in Oklahoma secondary agricultural education classes. The study was framed by the diffusion of…

  17. Velocity of climate change algorithms for guiding conservation and management.

    Science.gov (United States)

    Hamann, Andreas; Roberts, David R; Barber, Quinn E; Carroll, Carlos; Nielsen, Scott E

    2015-02-01

    The velocity of climate change is an elegant analytical concept that can be used to evaluate the exposure of organisms to climate change. In essence, one divides the rate of climate change by the rate of spatial climate variability to obtain a speed at which species must migrate over the surface of the earth to maintain constant climate conditions. However, to apply the algorithm for conservation and management purposes, additional information is needed to improve realism at local scales. For example, destination information is needed to ensure that vectors describing speed and direction of required migration do not point toward a climatic cul-de-sac by pointing beyond mountain tops. Here, we present an analytical approach that conforms to standard velocity algorithms if climate equivalents are nearby. Otherwise, the algorithm extends the search for climate refugia, which can be expanded to search for multivariate climate matches. With source and destination information available, forward and backward velocities can be calculated allowing useful inferences about conservation of species (present-to-future velocities) and management of species populations (future-to-present velocities).

  18. Climatic changes: explicative guide of international agreements; Changements climatiques: guide explicatif des accords internationaux

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The following themes of the negotiation in the United Nations Convention framework, on the climatic changes and the kyoto protocol are taken into account: the observation, the information communication, the policies and the measures, the developing countries, the flexibility mechanisms, the soils utilizations and the regime evolution. For each theme the document recalls quickly how the theme is detailed in the Convention and in the Protocol, it presents then the decisions and the adopted rules and defines the agreements contain, in terms of challenges and implication in the protocol implementation. (A.L.B.)

  19. Forecasting hypoxia in the Chesapeake Bay and Gulf of Mexico: model accuracy, precision, and sensitivity to ecosystem change

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Mary Anne; Scavia, Donald, E-mail: mevans@umich.edu, E-mail: scavia@umich.edu [School of Natural Resources and Environment, University of Michigan, Ann Arbor, MI 48109 (United States)

    2011-01-15

    Increasing use of ecological models for management and policy requires robust evaluation of model precision, accuracy, and sensitivity to ecosystem change. We conducted such an evaluation of hypoxia models for the northern Gulf of Mexico and Chesapeake Bay using hindcasts of historical data, comparing several approaches to model calibration. For both systems we find that model sensitivity and precision can be optimized and model accuracy maintained within reasonable bounds by calibrating the model to relatively short, recent 3 year datasets. Model accuracy was higher for Chesapeake Bay than for the Gulf of Mexico, potentially indicating the greater importance of unmodeled processes in the latter system. Retrospective analyses demonstrate both directional and variable changes in sensitivity of hypoxia to nutrient loads.

  20. A Course Exploration: Guiding Instruction to Prepare Students as Change Agents in Educational Reform

    Directory of Open Access Journals (Sweden)

    Kathy L. Church, EdD

    2010-08-01

    Full Text Available This article explores the premise of teacher identity development through course experiences directed at inquiry and social awareness. The course exploration examines the use of various strategies used to help promote educators as change agents. Pre-service students enrolled in a one-year master’s program with teaching credential participated in a yearlong course designed to engage them in guided inquiry while making connections between theory and practice. Evaluation of the projects and student perceptions of their work suggest that guided inquiry into educational issues builds critical thinking skills and a sense of purpose, leadership, and service through shaping teacher identity.

  1. SU-E-J-03: Characterization of the Precision and Accuracy of a New, Preclinical, MRI-Guided Focused Ultrasound System for Image-Guided Interventions in Small-Bore, High-Field Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Ellens, N [Johns Hopkins University, Baltimore, Maryland (United States); Farahani, K [National Cancer Institute, Bethesda, MD (United States)

    2015-06-15

    Purpose: MRI-guided focused ultrasound (MRgFUS) has many potential and realized applications including controlled heating and localized drug delivery. The development of many of these applications requires extensive preclinical work, much of it in small animal models. The goal of this study is to characterize the spatial targeting accuracy and reproducibility of a preclinical high field MRgFUS system for thermal ablation and drug delivery applications. Methods: The RK300 (FUS Instruments, Toronto, Canada) is a motorized, 2-axis FUS positioning system suitable for small bore (72 mm), high-field MRI systems. The accuracy of the system was assessed in three ways. First, the precision of the system was assessed by sonicating regular grids of 5 mm squares on polystyrene plates and comparing the resulting focal dimples to the intended pattern, thereby assessing the reproducibility and precision of the motion control alone. Second, the targeting accuracy was assessed by imaging a polystyrene plate with randomly drilled holes and replicating the hole pattern by sonicating the observed hole locations on intact polystyrene plates and comparing the results. Third, the practicallyrealizable accuracy and precision were assessed by comparing the locations of transcranial, FUS-induced blood-brain-barrier disruption (BBBD) (observed through Gadolinium enhancement) to the intended targets in a retrospective analysis of animals sonicated for other experiments. Results: The evenly-spaced grids indicated that the precision was 0.11 +/− 0.05 mm. When image-guidance was included by targeting random locations, the accuracy was 0.5 +/− 0.2 mm. The effective accuracy in the four rodent brains assessed was 0.8 +/− 0.6 mm. In all cases, the error appeared normally distributed (p<0.05) in both orthogonal axes, though the left/right error was systematically greater than the superior/inferior error. Conclusions: The targeting accuracy of this device is sub-millimeter, suitable for many

  2. Precise automatic image coregistration tools to enable pixel-level change detection Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Automated detection of land cover changes between multitemporal images has long been a goal of the remote sensing discipline. Most research in this area has focused...

  3. Precise Automatic Image Coregistration Tools to Enable Pixel-Level Change Detection Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Automated detection of land cover changes between multitemporal images (i.e., images captured at different times) has long been a goal of the remote sensing...

  4. Applications of Optical Interferometer Techniques for Precision Measurements of Changes in Temperature, Growth and Refractive Index of Materials

    Directory of Open Access Journals (Sweden)

    Rami Reddy Bommareddi

    2014-05-01

    Full Text Available Optical metrology techniques used to measure changes in thickness; temperature and refractive index are surveyed. Optical heterodyne detection principle and its applications for precision measurements of changes in thickness and temperature are discussed. Theoretical formulations are developed to estimate crystal growth rate, surface roughness and laser cooling/heating of solids. Applications of Michelson and Mach-Zehnder interferometers to measure temperature changes in laser heating of solids are described. A Mach-Zehnder interferometer is used to measure refractive index and concentration variations of solutions in crystal growth experiments. Additionally, fluorescence lifetime sensing and fluorescence ratio method are described for temperature measurement. For all the above techniques, uncertainty calculations are included.

  5. TIME-SPACE CONCEPT FOR PRECISION MEASUREMENT

    Institute of Scientific and Technical Information of China (English)

    LIU Xiaokang; PENG Donglin; ZHU Ge; WANG Xianquan

    2008-01-01

    The transformation between time and space is discussed. To improve real-time response speed of intelligent measuring system, the concept of exchanging program execution time with more circuitry is presented working in cycle mode. Displacement measuring by magnification is achieved with period measurement by magnification. To change the condition that traditional precision measurement depends on machining precision greatly, the concept of measuring space with time and theory of time-space coordinate transformation are proposed. Guided by the idea of measuring space with time, differential frequency measurement system and time grating displacement sensor are developed based on the proposed novel methods. And high-precision measurement is achieved without high-precision manufacture, which embeds the remarkable characteristics of low cost but high precision to the devices. Experiment and test results conform the validity of the proposed time-space concept.

  6. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 - Ethics, Challenges and Endeavors of Precision Nutrition.

    Science.gov (United States)

    Kohlmeier, Martin; De Caterina, Raffaele; Ferguson, Lynnette R; Görman, Ulf; Allayee, Hooman; Prasad, Chandan; Kang, Jing X; Nicoletti, Carolina Ferreira; Martinez, J Alfredo

    2016-01-01

    Nutrigenetics considers the influence of individual genetic variation on differences in response to dietary components, nutrient requirements and predisposition to disease. Nutrigenomics involves the study of interactions between the genome and diet, including how nutrients affect the transcription and translation process plus subsequent proteomic and metabolomic changes, and also differences in response to dietary factors based on the individual genetic makeup. Personalized characteristics such as age, gender, physical activity, physiological state and social status, and special conditions such as pregnancy and risk of disease can inform dietary advice that more closely meets individual needs. Precision nutrition has a promising future in treating the individual according to their phenotype and genetic characteristics, aimed at both the treatment and prevention of disease. However, many aspects are still in progress and remain as challenges for the future of nutrition. The integration of the human genotype and microbiome needs to be better understood. Further advances in data interpretation tools are also necessary, so that information obtained through newer tests and technologies can be properly transferred to consumers. Indeed, precision nutrition will integrate genetic data with phenotypical, social, cultural and personal preferences and lifestyles matters to provide a more individual nutrition, but considering public health perspectives, where ethical, legal and policy aspects need to be defined and implemented.

  7. The bottom line on climate change : a Manitoba business guide : version 1

    Energy Technology Data Exchange (ETDEWEB)

    Swain, A.

    2006-07-15

    Climate changes may pose risks to small businesses by threatening natural resources or capital that many businesses rely on for raw material. In addition, policies on climate change may influence the market to favour less energy-intensive businesses, products and services. Public pressure may also mean that business customers will increasingly prefer climate-friendly products. This guide was created to help small and medium-sized businesses in Manitoba understand the business impacts of climate change. The guide provided resources for businesses to find beneficial and profitable solutions as well as information on how to diversify markets and products. Key benefits of responding to climate change were identified as reduced costs and higher productivity; potential new revenues such as climate-friendly technologies, products and services; enhanced brand image; improved employee morale; and reduced liability and risk. Basic information on climate change in Manitoba was provided, as well as an outline of the easiest ways to save money and reduce greenhouse gas (GHG) emissions. Climate change costs that may affect small businesses were reviewed. Recommendations for negotiating impacts to businesses were also included. A basic climate change plan was presented with a number of provincial resources. Specific resources for different types of small businesses were also provided. 3 tabs.

  8. QuantFusion: Novel Unified Methodology for Enhanced Coverage and Precision in Quantifying Global Proteomic Changes in Whole Tissues.

    Science.gov (United States)

    Gunawardena, Harsha P; O'Brien, Jonathon; Wrobel, John A; Xie, Ling; Davies, Sherri R; Li, Shunqiang; Ellis, Matthew J; Qaqish, Bahjat F; Chen, Xian

    2016-02-01

    Single quantitative platforms such as label-based or label-free quantitation (LFQ) present compromises in accuracy, precision, protein sequence coverage, and speed of quantifiable proteomic measurements. To maximize the quantitative precision and the number of quantifiable proteins or the quantifiable coverage of tissue proteomes, we have developed a unified approach, termed QuantFusion, that combines the quantitative ratios of all peptides measured by both LFQ and label-based methodologies. Here, we demonstrate the use of QuantFusion in determining the proteins differentially expressed in a pair of patient-derived tumor xenografts (PDXs) representing two major breast cancer (BC) subtypes, basal and luminal. Label-based in-spectra quantitative peptides derived from amino acid-coded tagging (AACT, also known as SILAC) of a non-malignant mammary cell line were uniformly added to each xenograft with a constant predefined ratio, from which Ratio-of-Ratio estimates were obtained for the label-free peptides paired with AACT peptides in each PDX tumor. A mixed model statistical analysis was used to determine global differential protein expression by combining complementary quantifiable peptide ratios measured by LFQ and Ratio-of-Ratios, respectively. With minimum number of replicates required for obtaining the statistically significant ratios, QuantFusion uses the distinct mechanisms to "rescue" the missing data inherent to both LFQ and label-based quantitation. Combined quantifiable peptide data from both quantitative schemes increased the overall number of peptide level measurements and protein level estimates. In our analysis of the PDX tumor proteomes, QuantFusion increased the number of distinct peptide ratios by 65%, representing differentially expressed proteins between the BC subtypes. This quantifiable coverage improvement, in turn, not only increased the number of measurable protein fold-changes by 8% but also increased the average precision of quantitative

  9. Precision manufacturing

    CERN Document Server

    Dornfeld, David

    2008-01-01

    Today there is a high demand for high-precision products. The manufacturing processes are now highly sophisticated and derive from a specialized genre called precision engineering. Precision Manufacturing provides an introduction to precision engineering and manufacturing with an emphasis on the design and performance of precision machines and machine tools, metrology, tooling elements, machine structures, sources of error, precision machining processes and precision process planning. As well as discussing the critical role precision machine design for manufacturing has had in technological developments over the last few hundred years. In addition, the influence of sustainable manufacturing requirements in precision processes is introduced. Drawing upon years of practical experience and using numerous examples and illustrative applications, David Dornfeld and Dae-Eun Lee cover precision manufacturing as it applies to: The importance of measurement and metrology in the context of Precision Manufacturing. Th...

  10. 一种用于液体静压导轨的高精密液压站设计%Design of the Ultra-precision Hydraulic Station for Hydraulic Static Pressured Guide

    Institute of Scientific and Technical Information of China (English)

    赵午云; 郭勇

    2014-01-01

    Hydraulic static pressured guide is the important function unit of precision machine tool. Hydraulic station is indispen-sable and supplementary unit for hydraulic static pressured guide in normal operation,and must provide hydraulic static pressured guide with lubricating oil of invariable pressure. An ultra-precision hydraulic station for hydraulic static pressured guide was designed. In this hydraulic station,lubricating oil was provided by precision gear pump driven by variable frequency motor,and pressure export was ensured to be steady by full-closed loop feedback control. The export pressure precision of the hydraulic station can reach ± 0.05%. Good effect is gained in the application of the hydraulic station on the hydraulic static pressured guide of ultra-precision machine tool.%液体静压导轨是精密超精密加工机床的重要功能单元,液压站是液体静压导轨正常工作的必要辅助单元。液体静压导轨要保持高的精度,液压站必须能够为静压导轨提供压力非常稳定的润滑油输入。设计一种用于液体静压导轨的高精密液压站,该液压站利用变频电机驱动精密齿轮泵供给润滑油,利用全闭环反馈调节装置控制润滑油的稳压输出。实际测量证明:该液压站的输出压力稳定精度可达±0.05%,应用于超精密机床上的液体静压导轨取得了良好的效果。

  11. COP15 for journalists: a guide to the UN climate change summit

    Energy Technology Data Exchange (ETDEWEB)

    Shanahan, Mike

    2009-11-15

    Governments gather in Denmark in December 2009 for what is perhaps the most important meeting since the end of the second world war. December is the deadline they have set themselves for agreeing on action to tackle climate change, and the COP15 conference in Copenhagen is where hopes are high that a new global deal can be struck. This briefing is a guide for journalists reporting on this event, its buildup and its aftermath. It explains key processes, major actions to be agreed and possible outcomes.

  12. From Planning to Implementation: An Examination of Changes in the Research Design, Sample Size, and Precision of Group Randomized Trials Launched by the Institute of Education Sciences

    Science.gov (United States)

    Spybrook, Jessaca; Puente, Anne Cullen; Lininger, Monica

    2013-01-01

    This article examines changes in the research design, sample size, and precision between the planning phase and implementation phase of group randomized trials (GRTs) funded by the Institute of Education Sciences. Thirty-eight GRTs funded between 2002 and 2006 were examined. Three studies revealed changes in the experimental design. Ten studies…

  13. Resilience-Based Perspectives to Guiding High-Nature-Value Farmland through Socioeconomic Change

    Directory of Open Access Journals (Sweden)

    Tobias Plieninger

    2013-12-01

    Full Text Available Global environmental challenges require approaches that integrate biodiversity conservation, food production, and livelihoods at landscape scales. We reviewed the approach of conserving biodiversity on "high-nature-value" (HNV farmland, covering 75 million ha in Europe, from a resilience perspective. Despite growing recognition in natural resource policies, many HNV farmlands have vanished, and the remaining ones are vulnerable to socioeconomic changes. Using landscape-level cases across Europe, we considered the following social-ecological system properties and components and their integration into HNV farmland management: (1 coupling of social and ecological systems, (2 key variables, (3 adaptive cycles, (4 regime shifts, (5 cascading effects, (6 ecosystem stewardship and collaboration, (7 social capital, and (8 traditional ecological knowledge. We argue that previous conservation efforts for HNV farmland have focused too much on static, isolated, and monosectoral conservation strategies, and that stimulation of resilience and adaptation is essential for guiding HNV farmland through rapid change.

  14. Indication of BOLD-specific venous flow-volume changes from precisely controlled hyperoxic vs. hypercapnic calibration.

    Science.gov (United States)

    Mark, Clarisse I; Pike, G Bruce

    2012-04-01

    Deriving cerebral metabolic rate of oxygen consumption (CMRO(2)) from blood oxygenation level-dependent (BOLD) signals involves a flow-volume parameter (α), reflecting total cerebral blood volume changes, and a calibration constant (M). Traditionally, the former is assumed a fixed value and the latter is measured under alterations in fixed inspired fractional concentrations of carbon dioxide. We recently reported on reductions in M-variability via precise control of end-tidal pressures of both hypercapnic (HC) and hyperoxic (HO) gases. In light of these findings, our aim was to apply the improved calibration alternatives to neuronal activation, making use of their distinct vasoactive natures to evaluate the α-value. Nine healthy volunteers were imaged at 3 T while simultaneously measuring BOLD and arterial spin-labeling signals during controlled, graded, HC, and HO, followed by visual (VC) and sensorimotor cortices (SMC) activation. On the basis of low M- and CMRO(2)-variability, the comparison of these calibration alternatives accurately highlighted a reduced venous flow-volume relationship (α=0.16±0.02, with α(VC)=0.12±0.04, and α(SMC)=0.20±0.02), as appropriate for BOLD modeling.

  15. 肿瘤精确放疗新进展——图像引导自适应放疗%New Advance of Precise Radiotherapy: Image-guided Adaptive Radiation Therapy

    Institute of Scientific and Technical Information of China (English)

    王锐濠; 张书旭; 林生趣

    2012-01-01

    图像引导自适应放疗(ART)是一种新型的肿瘤精确放疗技术,它是继三维适形放疗(3D-CRT)和三维调强放疗(IMRT)之后,随着图像引导放疗(IGRT)的普遍应用而发展起来的.ART可以较好地解决放疗分次间的靶区位置和形态变化问题,适用于各种部位的肿瘤.对于鼻咽癌患者和(或)体重明显下降的头颈部肿瘤患者,采用ART可使PTV的边界缩小,减少腮腺等危及器官所受剂量,降低放疗毒副反应.对于胸腹部肿瘤,ART可有效解决分次治疗间的靶区运动问题,在提高肿瘤照射剂量的同时有效降低同侧正常肺组织的受照剂量,使肺毒性降到最低.前列腺癌由于受膀胱和直肠充盈程度的影响,靶区的变形有时会比较大,采用ART可显著降低直肠副反应发生的概率,也可消除直肠扩张对治疗的影响.而对膀胱癌和宫颈癌患者进行分次治疗时,采用在线ART技术更新治疗计划,可明显减少肿瘤靶区周围危及器官的辐射剂量,保护直肠和大肠等危及器官,从而降低放射性直肠炎、放射性膀胱炎等放疗并发症的发生概率.%Image-guided adaptive radiation therapy (ART) is one of the newly techniques in the field of precise radiotherapy, which is developed with the universal application of image-guided radiotherapy (IGRT) following by the three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (MRT). ART can effectively correct for inter- and intra-fraction variation during radiation therapy and is applicable for the treatment of various anatomical parts of the tumor. For patients with nasopharyngeal carcinoma and (or) weight loss, ART can achieve significant clinical efficacy of which reduces the margin of the planning target volume (PTV), accordingly reducing radiation dose of organs at risk such as the parotid so as to minimize the radioactive toxic side effects. ART really reduces the impact of interfractional variations in patient

  16. 77 FR 52741 - Compliance Policy Guide Sec. 420.300 Changes in Compendial Specifications and New Drug...

    Science.gov (United States)

    2012-08-30

    ... Specifications and New Drug Application Supplements; Withdrawal of Guidance AGENCY: Food and Drug Administration... withdrawal of Compliance Policy Guide (CPG) Sec. 420.300 Changes in Compendial Specifications and New Drug...: Changes to an Approved NDA or Abbreviated New Drug Application, which is available on the Internet at...

  17. Preface: Monitoring and modelling to guide coastal adaptation to extreme storm events in a changing climate

    Science.gov (United States)

    Brown, J. M.; Ciavola, P.; Masselink, G.; McCall, R.; Plater, A. J.

    2016-02-01

    Storms across the globe and their associated consequences in coastal zones (flooding and erosion), combined with the long-term geomorphic evolution of our coastlines, are a threat to life and assets, both socioeconomic and environmental. In a changing climate, with a rising global sea level, potentially changing patterns in storm tracks and storminess, and rising population density and pressures on the coastal zone, the future risk of coastal storm impacts is likely to increase. Coastal managers and policy makers therefore need to make effective and timely decisions on the use of resources for the immediate and longer Research focused on "monitoring and modelling to guide coastal adaptation to extreme storm events in a changing climate" is becoming more common; its goal is to provide science-based decision support for effective adaptation to the consequences of storm impacts, both now and under future climate scenarios at the coast. The growing transfer of information between the science community and end-users is enabling leading research to have a greater impact on the socioeconomic resilience of coastal communities. This special issue covers recent research activities relating to coastal hazard mapping in response to extreme events, economic impacts of long-term change, coastal processes influencing management decisions and the development of online decision support tools.

  18. 超声定位下48例隐匿性乳腺病灶精准切除%Ultrasound-guided precise resection of 48 cases of occult breast lesions

    Institute of Scientific and Technical Information of China (English)

    赵宁; 滕长胜

    2012-01-01

    Objective To explore the clinical significance of occult breast lesions biopsy,determine the operating methods of ultrasound-guided precisie resection of occult breast lesions,improve early diagnosis rate of breast cancer.Methods Forty-eight occult breast lesions of 44 patients were reviewed by localization-needle and skin markers method under ultrasound-guided,and the lesions were removed surgically according to the fixed steps.Results It was confirmed that all the impalpable mammary masses were exactly excised without localization-needle fracture or prolapse through postoperative pathological diagnosis.Breast appearance had no change after the operation.No nipple-areola necrosis occurred.The pathology results showed 4 cases of invasive ductal carcinoma (Ⅰ stage),the incidence rate being 8.3%,and 15 cases of atypical hyperplasia,the incidence rate being 31.3%.The other types were benign disease such as adenosis,intraductal papilloma,fibroadenoma and mammary duct ectasia.Conclusions Ultrasound-guided precise resection of occult breast lesions is a safe and effective diagnosis and treatment method,which needs some surgical skills.It has positive significance in improving breast cancer early diagnosis rate,reducing medical costs and decreasing breast biopsies complications.%目的 探讨隐匿性乳腺病灶手术活检的临床意义,确定超声定位下隐匿性乳腺病灶精准切除的操作方法,提高乳腺癌的早期诊断率.方法 44例患者的48例隐匿性乳腺病灶,在超声引导下采用定位针与体表标记相结合的方法定位,按照固定的步骤进行开放手术切除.结果 通过病理诊断证实病灶全部被准确切除,未发生定位针断裂、脱出等情况,术后乳房外形均未发生变化,未发生乳头乳晕坏死的并发症.病理结果:浸润性导管癌(Ⅰ期)4例,占8.3%;乳腺非典型增生15例,占31.3%;其余为乳腺腺病、乳管内乳头状瘤、乳腺纤维腺瘤、乳腺导管扩

  19. Adapting to climate change in forest based land use systems: A guide to strategy

    Energy Technology Data Exchange (ETDEWEB)

    Secrett, C.M.

    1996-12-31

    The prospect of climate change and sea level rise as a result of greenhouse gas emissions presents a serious challenge to decision-makers concerned with ensuring sustainable development. This report provides a guide to means of reducing the potential impact of the global warming problem on the forest sector whilst ensuring that more immediate development priorities are met. The most effective response strategy will be one that simultaneously brings both immediate development and longer-term adaptive benefits. This report outlines ways of constructing an adaptive response strategy that can help achieve these ends. The approach is referred to as sustainable adaptation. A prototype methodological framework of the sustainable adaptation approach has been provided with the summary. The first priority of sustainable adaption is to base climate change responses on actions that meet basic ecological and social needs now and in the future. Solutions should necessarily include relieving current development pressures in the tropical forest sector. The key is to couple adaptive responses to climate change with sustainable development solutions to present-day forest use problems. Implementing adaptive land-use policies and management practices which are likely to minimise the adverse impacts of anticipated climate change should meet current sustainable management goals. Implementing sustainable land-use and forestry management practices should meet adaptation goals. This report presents a discussion of the fundamental issues underlying the development of a sustainable adaptation strategy and a prototype methodological framework. The findings are based on case studies conducted in Central America (Costa Rica and Nicaragua); SADCC countries in Africa (Zimbabwe, Botswana, Tanzania); and Asia (Vietnam). 450 refs

  20. Why precision?

    Energy Technology Data Exchange (ETDEWEB)

    Bluemlein, Johannes

    2012-05-15

    Precision measurements together with exact theoretical calculations have led to steady progress in fundamental physics. A brief survey is given on recent developments and current achievements in the field of perturbative precision calculations in the Standard Model of the Elementary Particles and their application in current high energy collider data analyses.

  1. Deformable Image Registration for Adaptive Radiation Therapy of Head and Neck Cancer: Accuracy and Precision in the Presence of Tumor Changes

    Energy Technology Data Exchange (ETDEWEB)

    Mencarelli, Angelo, E-mail: a.mencarelli@nki.nl [Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands); Kranen, Simon Robert van; Hamming-Vrieze, Olga; Beek, Suzanne van [Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands); Nico Rasch, Coenraad Robert [Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands); Department of Radiation Oncology, Amsterdam Medical Centre, Amsterdam (Netherlands); Herk, Marcel van; Sonke, Jan-Jakob [Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands)

    2014-11-01

    Purpose: To compare deformable image registration (DIR) accuracy and precision for normal and tumor tissues in head and neck cancer patients during the course of radiation therapy (RT). Methods and Materials: Thirteen patients with oropharyngeal tumors, who underwent submucosal implantation of small gold markers (average 6, range 4-10) around the tumor and were treated with RT were retrospectively selected. Two observers identified 15 anatomical features (landmarks) representative of normal tissues in the planning computed tomography (pCT) scan and in weekly cone beam CTs (CBCTs). Gold markers were digitally removed after semiautomatic identification in pCTs and CBCTs. Subsequently, landmarks and gold markers on pCT were propagated to CBCTs, using a b-spline-based DIR and, for comparison, rigid registration (RR). To account for observer variability, the pair-wise difference analysis of variance method was applied. DIR accuracy (systematic error) and precision (random error) for landmarks and gold markers were quantified. Time trend of the precisions for RR and DIR over the weekly CBCTs were evaluated. Results: DIR accuracies were submillimeter and similar for normal and tumor tissue. DIR precision (1 SD) on the other hand was significantly different (P<.01), with 2.2 mm vector length in normal tissue versus 3.3 mm in tumor tissue. No significant time trend in DIR precision was found for normal tissue, whereas in tumor, DIR precision was significantly (P<.009) degraded during the course of treatment by 0.21 mm/week. Conclusions: DIR for tumor registration proved to be less precise than that for normal tissues due to limited contrast and complex non-elastic tumor response. Caution should therefore be exercised when applying DIR for tumor changes in adaptive procedures.

  2. BioCore Guide: A Tool for Interpreting the Core Concepts of Vision and Change for Biology Majors.

    Science.gov (United States)

    Brownell, Sara E; Freeman, Scott; Wenderoth, Mary Pat; Crowe, Alison J

    2014-01-01

    Vision and Change in Undergraduate Biology Education outlined five core concepts intended to guide undergraduate biology education: 1) evolution; 2) structure and function; 3) information flow, exchange, and storage; 4) pathways and transformations of energy and matter; and 5) systems. We have taken these general recommendations and created a Vision and Change BioCore Guide-a set of general principles and specific statements that expand upon the core concepts, creating a framework that biology departments can use to align with the goals of Vision and Change. We used a grassroots approach to generate the BioCore Guide, beginning with faculty ideas as the basis for an iterative process that incorporated feedback from more than 240 biologists and biology educators at a diverse range of academic institutions throughout the United States. The final validation step in this process demonstrated strong national consensus, with more than 90% of respondents agreeing with the importance and scientific accuracy of the statements. It is our hope that the BioCore Guide will serve as an agent of change for biology departments as we move toward transforming undergraduate biology education.

  3. BioCore Guide: A Tool for Interpreting the Core Concepts of Vision and Change for Biology Majors

    Science.gov (United States)

    Brownell, Sara E.; Freeman, Scott; Wenderoth, Mary Pat; Crowe, Alison J.

    2014-01-01

    "Vision and Change in Undergraduate Biology Education" outlined five core concepts intended to guide undergraduate biology education: 1) evolution; 2) structure and function; 3) information flow, exchange, and storage; 4) pathways and transformations of energy and matter; and 5) systems. We have taken these general recommendations and…

  4. SU-E-P-54: Evaluation of the Accuracy and Precision of IGPS-O X-Ray Image-Guided Positioning System by Comparison with On-Board Imager Cone-Beam Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, D; Wang, W; Jiang, B; Fu, D [Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin (China)

    2015-06-15

    Purpose: The purpose of this study is to assess the positioning accuracy and precision of IGPS-O system which is a novel radiographic kilo-voltage x-ray image-guided positioning system developed for clinical IGRT applications. Methods: IGPS-O x-ray image-guided positioning system consists of two oblique sets of radiographic kilo-voltage x-ray projecting and imaging devices which were equiped on the ground and ceiling of treatment room. This system can determine the positioning error in the form of three translations and three rotations according to the registration of two X-ray images acquired online and the planning CT image. An anthropomorphic head phantom and an anthropomorphic thorax phantom were used for this study. The phantom was set up on the treatment table with correct position and various “planned” setup errors. Both IGPS-O x-ray image-guided positioning system and the commercial On-board Imager Cone-beam Computed Tomography (OBI CBCT) were used to obtain the setup errors of the phantom. Difference of the Result between the two image-guided positioning systems were computed and analyzed. Results: The setup errors measured by IGPS-O x-ray image-guided positioning system and the OBI CBCT system showed a general agreement, the means and standard errors of the discrepancies between the two systems in the left-right, anterior-posterior, superior-inferior directions were −0.13±0.09mm, 0.03±0.25mm, 0.04±0.31mm, respectively. The maximum difference was only 0.51mm in all the directions and the angular discrepancy was 0.3±0.5° between the two systems. Conclusion: The spatial and angular discrepancies between IGPS-O system and OBI CBCT for setup error correction was minimal. There is a general agreement between the two positioning system. IGPS-O x-ray image-guided positioning system can achieve as good accuracy as CBCT and can be used in the clinical IGRT applications.

  5. Performance analysis of axial flow pump on gap changing between impeller and guide vane

    Science.gov (United States)

    Wang, W. J.; Liang, Q. H.; Wang, Y.; Yang, Y.; Yin, G.; Shi, X. X.

    2013-12-01

    In order to study the influence on gap changing of the static and dynamic components in axial flow pump, the axial flow pump model (TJ04-ZL-06) that used in the eastern of south-to-north water diversion project was selected. Steady turbulence field with different gaps was simulated by standard κ-ε turbulence model and double-time stepping methods. Information on the pressure distribution and velocity distribution of impeller surfaces were obtained. Then, calculated results were compared with the test results and analyzed. The results show that the performance of pump is not sensitive with the axial gap width under design conditions and the large flow rate condition. With increasing gap width, it will be improved in low flow rate condition. The attack angle of impeller inlet in small flow rate condition become small and the flow separation phenomenon can be observed in this condition. The axial velocity distribution of impeller outlet is nonlinear and to increase the axial gap is to improve the flow pattern near the hub effectively. The trend of calculating results is identical with test. It will play a guiding role to the axial pump operation and design in south-to-north water diversion project.

  6. Intelligent Transportation Systems: Automated Guided Vehicle Systems in Changing Logistics Environments

    Science.gov (United States)

    Schulze, L.; Behling, S.; Buhrs, S.

    2008-06-01

    The usage of Automated Guided Vehicle Systems (AGVS) is growing. This has not always been the case in the past. A new record of the sells numbers is the result of inventive developments, new applications and modern thinking. One market that AGVS were not able to thoroughly conquer yet were rapidly changing logistics environments. The advantages in recurrent transportation with AGVS used to be hindered by the needs of flexibility. When nowadays managers talk about Flexible Manufacturing Systems (FMS) there is no reason not to consider AGVS. Fixed guidelines, permanent transfer stations and static routes are no necessity for most AGVS producers. Flexible Manufacturing Systems can raise profitability with AGVS. When robots start saving billions in production costs, the next step at same plants are automated materials handling systems. Today, there are hundreds of instances of computer-controlled systems designed to handle and transport materials, many of which have replaced conventional human-driven platform trucks. Reduced costs due to damages and failures, tracking and tracing as well as improved production scheduling on top of fewer personnel needs are only some of the advantages.

  7. Histological changes at an endosonography-guided biliary drainage site: A case report

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Endosonography-guided biliary drainage (ESBD) is a new method enabling internal drainage of an obstructed bile duct. However, the histological conditions associated with fistula development via the duodenum to the bile duct have not been reported. We performed ESBD 14 d preoperatively in a patient with an ampullary carcinoma and histologically confirmed changes in and around the fistula. The female patient developed no complications relevant to ESBD. Levels of serum bilirubin and hepatobiliary enzymes declined quickly, and pancreatoduodenectomy was carried out uneventfully. The resected specimen was sliced and stained with hematoxylin-eosin. Histological evaluation of the puncture site in the duodenum and bile-duct wall, and the sinus tract revealed no hematoma, bile leakage, or abscess in or around the sinus tract. Little sign of granulation, fibrosis, and inflammatory cell infiltration was observed. Although further large-scale confirmatory studies are needed, the findings here may encourage more active use of ESBD as a substitute for percutaneous transhepatic drainage in cases with failed/difficult endoscopic biliary stenting.

  8. Precision mechanics

    CERN Document Server

    Kittell, David

    1989-01-01

    David Kittell, the father of the discipline, Precision Mechanics, shares the foundation of this science with you in his highly practical and fun to read book, Precision Mechanics. Based on his highly acclaimed course by the same name, first taught at the Perkin-Elmer Technical institute in Norwalk, Connecticut, and later as a short course offered in such places as Bell Labs, SPIE, IEEE, NASA, and several national labs, you will find this book relevant and immediately useful.

  9. Making change easy: A peer-to-peer guide on transitioning to new hand hygiene products.

    Science.gov (United States)

    Amirov, Chingiz M; Candon, Heather L; Jacob, Latha

    2017-01-01

    This report summarizes our experiences planning and implementing the transition to a new commercial line of hand hygiene products and their dispensing systems in a large academic health care facility in Toronto, Canada. Our lessons learned are organized into a practical guide made available in 2 different formats: this article and an illustrated peer-to-peer guide (http://www.baycrest.org/wp-content/uploads/HCE-PROG-HH_HighQuality.pdf).

  10. Precision metrology.

    Science.gov (United States)

    Jiang, X; Whitehouse, D J

    2012-08-28

    This article is a summary of the Satellite Meeting, which followed on from the Discussion Meeting at the Royal Society on 'Ultra-precision engineering: from physics to manufacture', held at the Kavli Royal Society International Centre, Chicheley Hall, Buckinghamshire, UK. The meeting was restricted to 18 invited experts in various aspects of precision metrology from academics from the UK and Sweden, Government Institutes from the UK and Germany and global aerospace industries. It examined and identified metrology problem areas that are, or may be, limiting future developments in precision engineering and, in particular, metrology. The Satellite Meeting was intended to produce a vision that will inspire academia and industry to address the solutions of those open-ended problems identified. The discussion covered three areas, namely the function of engineering parts, their measurement and their manufacture, as well as their interactions.

  11. “Cancer 2015”: A Prospective, Population-Based Cancer Cohort—Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic

    Directory of Open Access Journals (Sweden)

    John P. Parisot

    2015-10-01

    Full Text Available “Cancer 2015” is a longitudinal and prospective cohort. It is a phased study whose aim was to pilot recruiting 1000 patients during phase 1 to establish the feasibility of providing a population-based genomics cohort. Newly diagnosed adult patients with solid cancers, with residual tumour material for molecular genomics testing, were recruited into the cohort for the collection of a dataset containing clinical, molecular pathology, health resource use and outcomes data. 1685 patients have been recruited over almost 3 years from five hospitals. Thirty-two percent are aged between 61–70 years old, with a median age of 63 years. Diagnostic tumour samples were obtained for 90% of these patients for multiple parallel sequencing. Patients identified with somatic mutations of potentially “actionable” variants represented almost 10% of those tumours sequenced, while 42% of the cohort had no mutations identified. These genomic data were annotated with information such as cancer site, stage, morphology, treatment and patient outcomes and health resource use and cost. This cohort has delivered its main objective of establishing an upscalable genomics cohort within a clinical setting and in phase 2 aims to develop a protocol for how genomics testing can be used in real-time clinical decision-making, providing evidence on the value of precision medicine to clinical practice.

  12. Quality Problems of Design Process and Machining of Precision-guided Key Components%精确制导关键件工艺设计与加工中的质量问题

    Institute of Scientific and Technical Information of China (English)

    尚蓉; 王三民; 李红星

    2012-01-01

    精密薄壁腔体零件的加工周期长,加工难度大,如果对零件有气密性要求,则加工难度更大.若成品的气密性达不到要求,就会成为废品,严重影响产品的研制进度.对产品的气密性要求是武器装备的重要参数,是保证武器装备性能的重要战术指标.针对公司某精确制导关键件精密薄壁本体的加工制作,通过采取一系列工艺措施,达到了避免螺纹孔透孔现象的重复发生、提高零件加工质量和加工效率、缩短生产周期的目的.%Precision thin-walled parts have the characters like long machining period and hard machining, if there are re-quirements for seal quality, the machining will be harder. The parts will become production rejects if the seal quality can not meet the requirements, which affects hardly researching process. It is the important parameter that seal requirement, it is also the important tactical index ensuring property of weaponry. Focus on process research on precision guiding key parts precision thin-walled bodies of a company, through a series of technics, reached the goals of forbidding tap hole through hole, improving machining quality and machining efficiency of parts, and reducing manufacturing period.

  13. Identification of submicroscopic genetic changes and precise breakpoint mapping in myelofibrosis using high resolution mate-pair sequencing.

    Science.gov (United States)

    Lasho, Terra; Johnson, Sarah H; Smith, David I; Crispino, John D; Pardanani, Animesh; Vasmatzis, George; Tefferi, Ayalew

    2013-09-01

    We used high resolution mate-pair sequencing (HRMPS) in 15 patients with primary myelofibrosis (PMF): eight with normal karyotype and seven with PMF-characteristic cytogenetic abnormalities, including der(6)t(1;6)(q21-23;p21.3) (n = 4), der(7)t(1;7)(q10;p10) (n = 2), del(20)(q11.2q13.3) (n = 3), and complex karyotype (n = 1). We describe seven novel deletions/translocations in five patients (including two with normal karyotype) whose breakpoints were PCR-validated and involved MACROD2, CACNA2D4, TET2, SGMS2, LRBA, SH3D19, INTS3, FOP (CHTOP), SCLT1, and PHF17. Deletions with breakpoints involving MACROD2 (lysine deacetylase; 20p12.1) were recurrent and found in two of the 15 study patients. A novel fusion transcript was found in one of the study patients (INTS3-CHTOP), and also in an additional non-study patient with PMF. In two patients with der(6)t(1;6)(q21-23;p21.3), we were able to map the precise translocation breakpoints, which involved KCNN3 and GUSBP2 in one case and HYDIN2 in another. This study demonstrates the utility of HRMPS in uncovering submicroscopic deletions/translocations/fusions, and precise mapping of breakpoints in those with overt cytogenetic abnormalities. The overall results confirm the genetic heterogeneity of PMF, given the low frequency of recurrent specific abnormalities, identified by this screening strategy. Currently, we are pursuing the pathogenetic relevance of some of the aforementioned findings.

  14. 3D Precision Analysis of Interactive Computer-guided Implantology%数字化导板用于牙种植的三维精度分析

    Institute of Scientific and Technical Information of China (English)

    何女; 钱江; 赵佳佳; 翁丽华; 泮海松

    2015-01-01

    Objective: The purpose of this study was to investigate the clinical value of computer-guided digital template in implantology. Methods: From 2011 July to 2012 June, twenty-four implants of five patients were selected to measure the deviation between planned implants and actual implants by pre- and post-operative CBCT images. Patients accepted the CBCT scanning before the operation. A recently developed interactive 3D CT software program was applied to use raw data (DICOM files) from the CT scan to display reformatted CT images for the inspection of the bony anatomy of the alveo-lar ridges. The CT scan data obtained from the software can be used to produce sterolithographic models for 3D visualiza-tion of planning complex implantology. All patients had the CBCT scanning again after operation to get the 3D data of the actual implants. Results:Twenty-four implants were all obtained in ideal physiological positions. The deviation of the site, the depth and the axial angle of the three-dimensional direction was (0.22±0.07) mm, (0.17±0.08) mm, and (0.65±0.19) ° respectively. Conclusion: The oral digital template can accurately transfer the preoperative design, and avoid to damage the important anatomical structure of jaw bones, and obtain the satisfactory denture restoration.%目的:评估应用以修复为导向的数字化导板进行种植牙手术后,种植体在颌骨内的实际位置与软件模拟位置的误差,探讨数字化导板的临床应用价值。方法:2011-07—2012-06期间于诸暨市人民医院口腔种植中心进行数字化导板种植牙手术者,患者术前拍摄口腔锥形束CT(CBCT),获取DICOM格式的CT数据后制作数字化种植导板,完成种植手术后再次拍摄CBCT,获取实际种植体在颌骨内的具体三维位置。选取其中5例患者24枚种植体进行术前、术后精度比较。根据手术前后2次数据,在医学牙种植设计软件中进行三维重建,比较种植体实际位置

  15. Apparent survival rates of forest birds in eastern Ecuador revisited: improvement in precision but no change in estimates.

    Directory of Open Access Journals (Sweden)

    John G Blake

    Full Text Available Knowledge of survival rates of Neotropical landbirds remains limited, with estimates of apparent survival available from relatively few sites and species. Previously, capture-mark-recapture models were used to estimate apparent survival of 31 species (30 passerines, 1 Trochilidae from eastern Ecuador based on data collected from 2001 to 2006. Here, estimates are updated with data from 2001-2012 to determine how additional years of data affect estimates; estimates for six additional species are provided. Models assuming constant survival had highest support for 19 of 31 species when based on 12 years of data compared to 27 when based on six; models incorporating effects of transients had the highest support for 12 of 31 species compared to four when based on 12 and six years, respectively. Average apparent survival based on the most highly-supported model (based on model averaging, when appropriate was 0.59 (± 0.02 SE across 30 species of passerines when based on 12 years and 0.57 (± 0.02 when based on six. Standard errors of survival estimates based on 12 years were approximately half those based on six years. Of 31 species in both data sets, estimates of apparent survival were somewhat lower for 13, somewhat higher for 17, and remained unchanged for one; confidence intervals for estimates based on six and 12 years of data overlapped for all species. Results indicate that estimates of apparent survival are comparable but more precise when based on longer-term data sets; standard error of the estimates was negatively correlated with numbers of captures (rs  = -0.72 and recaptures (rs  = -0.93, P<0.001 in both cases. Thus, reasonable estimates of apparent survival may be obtained with relatively few years of data if sample sizes are sufficient.

  16. Precision Airdrop (Largage de precision)

    Science.gov (United States)

    2005-12-01

    commenced in March 2004 at Red Lake in Kingman, Arizona. Initial flights were remote controlled, executing planned maneuvers to establish the flight...Capewell and Vertigo AGAS The Affordable Guided Airdrop System (AGAS) by Capewell Components, Inc. of South Windsor, Connecticut and Vertigo, Inc. of Lake ... Elsinore , California, is an example of a controllable, round JPADS. The AGAS is a U.S. government/contractor development effort that started in 1999

  17. From mandatory icebreaker guiding to a permission regime:changes to the new Russian legislation of the Northern Sea Route

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xia; ZOU Leilei; TU Jingfang; QIAN Zongqi; WANG Zeming; YANG Huigen

    2014-01-01

    This article focuses on two issues. The first concerns definitions of the Northern Sea Route (NSR) in old and new Russian legislation, and the second relates to Russian rules on icebreaker guiding. Based on a comprehensive comparative analysis of relevant Russian legal provisions enacted in 2013 and previous laws in this area, we offer the following conclusions. (1) Our legal analysis indicates that Russia’s view of the NSR as a historical national transportation route has not changed. However, the new law redefines the scope and coverage of the NSR, which now comprises the internal waters, territorial sea, adjacent zone, and the exclusive economic zone of the Russian Federation. In fact, the new law resolves previous ambiguity regarding extension of the NSR boundary to the high seas. (2) Based on an analysis of the new rules on icebreaker guiding, the article concludes that NSR is transitioning from a mandatory icebreaker guiding regime into a permit regime. This is particularly evident in its provision of a concrete, practical, and predictable clause on permissible or impermissible conditions relating to independent navigation. According to the new rules, it is possible for foreign ships to undertake independent navigation in the NSR. The Russian NSR policy, therefore, appears to have changed significantly, and has future potential for opening the NSR up to the international community.

  18. Automatically gated image-guided breath-hold IMRT is a fast, precise, and dosimetrically robust treatment for lung cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Simeonova-Chergou, Anna; Jahnke, Anika; Siebenlist, Kerstin; Stieler, Florian; Mai, Sabine; Boda-Heggemann, Judit; Wenz, Frederik; Lohr, Frank; Jahnke, Lennart [University Medical Center Mannheim, University of Heidelberg, Department of Radiotherapy and Oncology, Mannheim (Germany)

    2016-03-15

    delivery precision for patients with small and larger lung tumors. (orig.) [German] Die Hochdosisstrahlentherapie des Bronchialkarzinoms ist eine Herausforderung. Bis zu 2 cm kann sich der Tumor in kraniokaudaler und anteroposteriorer Richtung bewegen - abhaengig vom Atemzyklus. Die Tumorverschiebung nimmt mit der Behandlungsdauer zu, was also die Behandlungsunsicherheit vermehrt. In der vorliegenden Studie wurde untersucht, ob die automatisch gesteuerte, Cone-Beam-Computertomographie(CBCT)-kontrollierte, intensitaetsmodulierte stereotaktische Strahlentherapie (''stereotactic body radiation therapy'', SBRT) im Atemanhalt nach schneller tiefer Inspiration (''deep inspiration breath hold'', DIBH) ohne Ausgleichskoerper (''flattening filter free'', FFF) und die mit einem Ausgleichskoerper applizierte normal fraktionierte intensitaetsmodulierte DIBH-Strahlentherapie/volumenmodulierte Strahlentherapie mit Rotation des Bestrahlungsarms (''volumetric-modulated arc therapy'', VMAT) der Lunge mit ausreichender Genauigkeit innerhalb eines klinisch akzeptablen Zeitfensters angewendet werden koennen. Die Bestrahlungsplaene von 34 Patienten mit Bronchialkarzinomen wurden ausgewertet. Von diesen Patienten erhielten 17 eine computergesteuerte SBRT mit schneller DIBH und einer Dosis von 60 Gy (5 Fraktionen a 12 Gy oder 12 Fraktionen a 5 Gy) in FFF-VMAT-Technik (FFF-SBRT) jeden 2. Tag, und 17 erhielten eine konventionelle VMAT mit Ausgleichskoerper (conv-VMAT) und taeglichen Teildosen von 2 Gy (kumulative Dosis: 50-70 Gy). Fuer Plaene mit FFF-SBRT waren mehr Ueberwachungseinheiten (''monitor units'', MU) erforderlich als fuer Plaene mit con-VMAT (2956,6 ± 885,3 MU fuer 12 Gy/Fraktion bzw. 1148,7 ± 289,2 MU fuer 5 Gy/Fraktion vs. 608,4 ± 157,5 MU fuer 2 Gy/Fraktion). Die Dauer der Gesamttherapie und der Beam-on-Zeit (''Strahl ein'') waren fuer FFF-SBRT-Plaene kuerzer

  19. Can we gain precision by sampling with probabilities proportional to size in surveying recent landscape changes in the Netherlands?

    NARCIS (Netherlands)

    Brus, D.J.; Nieuwenhuizen, W.; Koomen, A.J.M.

    2006-01-01

    Seventy-two squares of 100 ha were selected by stratified random sampling with probabilities proportional to size (pps) to survey landscape changes in the period 1996-2003. The area of the plots times the urbanization pressure was used as a size measure. The central question of this study is whether

  20. Changing Africa, Topic 3. Africa South of the Sahara: A Program of Study for Secondary School Social Studies Students. Teaching and Student Guides.

    Science.gov (United States)

    Carnegie-Mellon Univ., Pittsburgh, PA. Project Africa.

    This teaching guide and student text deal with four areas of change in contemporary Africa: (1) social change and the presence of industrialization, (2) changing patterns of work from a rural to an industrial-urban economy, (3) the impact of changing patterns in education on the lives of Africans, and (4) the nature of African cities and urban…

  1. 移动导向架高精度沉桩技术在外海桥梁工程中的应用%Application of moving guide frame method for high precision pile- sinking in offshore bridge engineering

    Institute of Scientific and Technical Information of China (English)

    张连江; 孙建波; 徐波

    2015-01-01

    The method of using moving guide frame to sinking piles is achieved by developing piling guide frame and fixing it up on one side of the barge, which acts as the locating boat with specific positioning systems to pile. With the help of crane barge to hoist the steel pipe piles, in the shape of hydraulic vibratory hammer first striking and the impact hammer re-driving to construct the large diameter ultra-long steel pipe piles. Using the high precision real-time measurement system to make sure the precision of pile-sinking in plane position will be no more than 10 cm and the squareness error will be lower than 1/250. The process has the advantage that when the piling deviation is exceed standard , the steel pipe pile can be pulling and re-sinking, the positive rate can achieve 100%compared with the traditional piling ship sinking process.%移动导向架高精度沉桩技术是通过在大型定位驳船的一侧布置特制的导向架,利用大型起重船吊桩入导向架定位,再起吊液压振动锤初打与冲击锤复打的外海大直径超长钢管桩施工技术。依靠研发的高精度实时测量定位系统,确保沉桩精度满足平面位置偏差不大于10 cm,垂直度偏差不大于1/250的高精度要求。该工艺具有沉桩偏位超标时能将钢管桩拔出重新振沉的优点,较传统的打桩船沉桩工艺可做到100%的正位率。

  2. Application Of New Spatial Statistical Stream Models For Precise Downscaling Of Climate Change Effects On Temperatures In River Networks

    Science.gov (United States)

    Isaak, D.; Luce, C.; Peterson, E.

    2009-12-01

    A warming climate will bring unprecedented changes to stream and river ecosystems, with temperature considerations being of utmost importance, given that most aquatic organisms are ectothermic. Previous broad-scale assessments of climate impacts to streams have been limited by inadequate availability of stream temperature data and often relied on surrogate relationships between air temperature and elevation that are often imprecise. Mechanistic models have sometimes been used to model stream thermal responses directly, but intensive parameterization limits the spatial scope of these applications. Modeling approaches are needed that address stream temperatures directly at the larger spatial scales commensurate with most conservation and restoration planning efforts. We applied new spatial statistical models that account for network topology (i.e., flow direction and volume) to an extensive, but non-random stream temperature database (n = 780) compiled across a 13 year period (1993-2006) for a large (2,500 km) mountain river network in central Idaho. Four predictors—radiation, elevation, air temperature, and stream flow—were used in the spatial model to represent important geomorphic and climatic effects on mean summer stream temperatures. The spatial models accounted for autocorrelation among sample sites to provide improved parameter estimates and predictive accuracy (R2 = 0.93; RMSPE = 0.74○C) relative to traditional, non-spatial models (R2 = 0.68; RMSPE = 1.53○C). A small bias between observed stream temperatures and those predicted by the spatial models amounted to 0.5○C at the extremes of the observed temperature range (5○C - 20○C) and caused over- (under-) predictions for the coldest (warmest) streams. This bias could have arisen from elevational gradients associated with influxes of cold, snowmelt groundwater or alterations in valley form due to past glacial activity. Better understanding regarding the importance of these and other factors that

  3. Evaluation of volume change in rectum and bladder during application of image-guided radiotherapy for prostate carcinoma

    Science.gov (United States)

    Luna, J. A.; Rojas, J. I.

    2016-07-01

    All prostate cancer patients from Centro Médico Radioterapia Siglo XXI receive Volumetric Modulated Arc Therapy (VMAT). This therapy uses image-guided radiotherapy (IGRT) with the Cone Beam Computed Tomography (CBCT). This study compares the planned dose in the reference CT image against the delivered dose recalculate in the CBCT image. The purpose of this study is to evaluate the anatomic changes and related dosimetric effect based on weekly CBCT directly for patients with prostate cancer undergoing volumetric modulated arc therapy (VMAT) treatment. The collected data were analyzed using one-way ANOVA.

  4. Precise Sediment Yield and Riverbed Change Detected by using LiDAR DTMs before and after a Typhoon Season

    Science.gov (United States)

    Hsieh, Y.; Chan, Y.; Hu, J.; Lin, C.

    2009-12-01

    Sediment yield and riverbed change from watersheds greatly influence the conservation of water and soil, the planning of hydraulic engineering, and the river habitat, etc. At present, sediment yield calculation often used empirical or theoretical formula as well as data collected at hydrological stations, and rarely had the actual measured value through high-resolution topography. The Lanyang river is one of main rivers in Taiwan and often suffers the influence of typhoon during summer. In 2008, there are four significant typhoon events influencing this area, including the Kalmaegi, Fung-wong, Sinlaku, and Jangmi typhoons. This study of topographic variations surveyed the terrain of the Lanyang River before and after the 2008 typhoon season using airborne LiDAR technique. The variations of the terrain on the riverbed may be regarded as the sediment yield of the bed load transported during the typhoon season. This research used high-resolution terrain models to compute sediment yield of the bed load, and further discussed sediment yield volume in the watershed during the typhoon season. In the Lanyang river we discovered that the upstream and midstream channels had significant characteristics of erosion and transportation during the typhoon season. The sediment on the riverbed reduced approximately 2.3 million cubic meters; and the erosion rate of the bed load sediments were estimated about 3.4 mm during the 2008 typhoon season. The results indicate that considerable sediment yield and transportation in the Lanyang river during only a single typhoon season in which cumulated rain falls are high. Further analysis of the collected data in the Lanyang river are needed to better understand the typhoon influence and apply the results to the prevention of the common flash flooding hazards.

  5. Research Institute for Autonomous Precision Guided Systems

    Science.gov (United States)

    2007-03-08

    Kruzik Charles University, Prague Mechanics of materials Adam Nadel George Washington Univ Robotics Tony Okafor Case Western University Robotics Carlos...University, Prague Mechanics of materials Adam Nadel George Washington Univ Robotics Tony Okafor Case Western University Robotics Carlos Oliveira UF...Assistant, University of Florida Nadel, Adams Graduate Research Assistant, George Washington University Okafor , Anthony Graduate Research Assistant

  6. Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites - thermographic analysis on bovine ribs

    Directory of Open Access Journals (Sweden)

    Marković Aleksa

    2016-01-01

    Full Text Available Background/Aim. During drilling implant sites, mechanical energy is converted into thermal one resulting in transient rise in temperature of surrounding bone. The temperature of 47°C exeeding one minute impairs osseointegration, compromises mechanical properties of the local bone and could cause early implant failure. This in vitro study aimed to assess the effect of surgical drill guide and temperature of irrigans on thermal changes of the local bone during drilling implant sites, and to test the influence of irrigans temperature on the temperature of surgical drill guide. Methods. A total of 48 specimens obtained from bovine ribs were randomly allocated to four experimental conditions according to the 2 x 2 factorial design: drill guide (with or without and saline (at 25°C or 5°C. Real-time infrared thermography was used as a method for temperature measurement. The primary outcome was bone temperature change during drilling implant sites measured at 3 osteotomy depths, whereas the second one was change in the temperature of the drill guide. Data were analyzed by Brunner and Langer nonparametric analysis and Wilcoxon test. Results. The effect of drill guide on the changes of bone temperature was significant at the entrance of osteotomy, whereas the effect of saline temperature was significant at all osteotomy levels (p 0.05. Guided surgery and irrigation with saline at 25°C were associated with the highest bone temperature increase. Increase in drill guide temperature was significantly higher when saline at 25°C was used (p < 0.001. Conclusion. Guided implant site preparation generates higher temperature of the local bone than conventional drilling, not exceeding the threshold for thermal bone necrosis. Although saline at room temperature provides sufficient heat control during drilling, cooled saline is more effective regardless the use of surgical drill guide.

  7. Incorporation of prior knowledge for region of change imaging from sparse scan data in image-guided surgery

    Science.gov (United States)

    Lee, J.; Stayman, J. W.; Otake, Y.; Schafer, S.; Zbijewski, W.; Khanna, A. J.; Prince, J. L.; Siewerdsen, J. H.

    2012-02-01

    This paper proposes to utilize a patient-specific prior to augment intraoperative sparse-scan data to accurately reconstruct the aspects of the region that have changed by a surgical procedure in image-guided surgeries. When anatomical changes are introduced by a surgical procedure, only a sparse set of x-ray images are acquired, and the prior volume is registered to these data. Since all the information of the patient anatomy except for the surgical change is already known from the prior volume, we highlight only the change by creating difference images between the new scan and digitally reconstructed radiographs (DRR) computed from the registered prior volume. The region of change (RoC) is reconstructed from these sparse difference images by a penalized likelihood (PL) reconstruction method regularized by a compressed sensing penalty. When the surgical changes are local and relatively small, the RoC reconstruction involves only a small volume size and a small number of projections, allowing much faster computation and lower radiation dose than is needed to reconstruct the entire surgical volume. The reconstructed RoC merges with the prior volume to visualize an updated surgical field. We apply this novel approach to sacroplasty phantom data obtained from a conebeam CT (CBCT) test bench and vertebroplasty data with a fresh cadaver acquired from a C-arm CBCT system with a flat-panel detector (FPD).

  8. Changes in the Precision of a Study from Planning Phase to Implementation Phase: Evidence from the First Wave of Group Randomized Trials Launched by the Institute of Education Sciences

    Science.gov (United States)

    Spybrook, Jessaca; Lininger, Monica; Cullen, Anne

    2011-01-01

    The purpose of this study is to extend the work of Spybrook and Raudenbush (2009) and examine how the research designs and sample sizes changed from the planning phase to the implementation phase in the first wave of studies funded by IES. The authors examine the impact of the changes in terms of the changes in the precision of the study from the…

  9. 精确制导武器天基路径规划平台概念研究%Conceptual Study of Space-based Attacking Path Planning Platform for Precision Guided Weapon

    Institute of Scientific and Technical Information of China (English)

    李恩奇; 李桢; 果琳丽; 梁鲁

    2015-01-01

    美国提出了C4KISR的作战概念,将K ( Kill,杀伤、摧毁能力)嵌入C4ISR系统(一体化指挥、控制、通信、计算机、情报、监视和侦察的信息系统, Command, Control, Communication, Computer, Information, Spy, Reconnais-sance)之中,将传统的C4ISR系统与杀伤紧密结合起来,实现侦察/监视———决策———杀伤———打击评估过程的一体化,形成同步、连续、动态、有机统一的C4KISR过程,产生新的作战能力。为了实现C4KISR,在武器精确打击的基础上更应该重视武器在发射之后的可控性。例如使用2枚巡航导弹打击敌指挥所,在第一枚命中目标后,需要确定第二枚导弹飞行轨迹、打击方式和打击位置,即实现巡航导弹“人在回路”的可控攻击模式。此时应为巡航导弹提供战场态势感知、打击效果评估、武器攻击路径时时规划等保障支持,天基平台无疑是这种保障支持的最佳选择。本文从现有文献到的精确制导武器用天需求出发,提出了建立精确制导武器攻击路径规划天基平台的概念。该平台主要由战场侦察、打击效果评估、精确制导武器通讯链路和武器任务规划四大系统组成。最后初步分析了可承担攻击路径规划天基平台任务的飞行器类型和各自优缺点,给出需进一步解决的关键技术。%C4KISR is a new concept put forward on the basis of C4ISR for meeting the current operation requirements of the American Army,constituted a integrated System for reconnaissance decision damage and assessment. For the realization of C4KISR, more attention need be payed to the controllability of precision guided weapon. Supposing 2 cruise missiles at-tacking a command post, after the first missile hitting the target, the flight trajectory, attack mode and attack position should be ascertained for the second one, which would achieve a attack mode with man in the loop. Space-based platform is the best choice

  10. Computed Tomography Number Changes Observed During Computed Tomography–Guided Radiation Therapy for Head and Neck Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Mei [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu (China); Yang, Cungeng; Chen, Xiaojian; Xu, Shouping; Moraru, Ion [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Lang, Jinyi [Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu (China); Schultz, Christopher [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Li, X. Allen, E-mail: ali@mcw.edu [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States)

    2015-04-01

    Purpose: To investigate CT number (CTN) changes in gross tumor volume (GTV) and organ at risk (OAR) according to daily diagnostic-quality CT acquired during CT-guided intensity modulated radiation therapy for head and neck cancer (HNC) patients. Methods and Materials: Computed tomography scans acquired using a CT-on-rails during daily CT-guided intensity modulated radiation therapy for 15 patients with stage II to IVa squamous cell carcinoma of the head and neck were analyzed. The GTV, parotid glands, spinal cord, and nonspecified tissue were generated on each selected daily CT. The changes in CTN distributions and the mean and mode values were collected. Pearson analysis was used to assess the correlation between the CTN change, organ volume reduction, and delivered radiation dose. Results: Volume and CTN changes for GTV and parotid glands can be observed during radiation therapy delivery for HNC. The mean (±SD) CTNs in GTV and ipsi- and contralateral parotid glands were reduced by 6 ± 10, 8 ± 7, and 11 ± 10 Hounsfield units, respectively, for all patients studied. The mean CTN changes in both spinal cord and nonspecified tissue were almost invisible (<2 Hounsfield units). For 2 patients studied, the absolute mean CTN changes in GTV and parotid glands were strongly correlated with the dose delivered (P<.001 and P<.05, respectively). For the correlation between CTN reductions and delivered isodose bins for parotid glands, the Pearson coefficient varied from −0.98 (P<.001) in regions with low-dose bins to 0.96 (P<.001) in high-dose bins and were patient specific. Conclusions: The CTN can be reduced in tumor and parotid glands during the course of radiation therapy for HNC. There was a fair correlation between CTN reduction and radiation doses for a subset of patients, whereas the correlation between CTN reductions and volume reductions in GTV and parotid glands were weak. More studies are needed to understand the mechanism for the radiation-induced CTN changes.

  11. Computed Tomography Guided Hook-wire Precise Localization and Minimally Invasive Resection of Pulmonary Nodules%CT引导下Hook-w ire精确定位并微创切除肺结节

    Institute of Scientific and Technical Information of China (English)

    王通; 马少华; 闫天生; 宋金涛; 王可毅; 贺未; 白洁

    2015-01-01

    ,积极微创手术治疗是非常必要的。%Background and objective Localization of pulmonary ground glass nodule is the technical diffculty of minimally invasive operation resection. hTe aim of this study is to evaluate the value of computed tomography (CT)-guided Hook-wire precise localization in resection of pulmonary nodules by video-assisted thoracoscopic surgery (VATS) as well as to discuss the necessity and feasibility of surgical resection of GGOs through a minimally invasive approach.Methods CT-guided Hook-wire precise localization and wedge resection was done on 25 cases with 26 pulmonary nodules by VATS from May 2013 to June 2015. hTe effcacy of localization was evaluated in terms of procedure time, VATS success rate, and associated complications of localization.Results All the 26 pulmonary nodules (6 solid nodules and 20 GGOs ) of 25 patients (10 males and 15 females) were preoperatively detected and localized with Hook-wire under CT guidance. Nodule diameters ranged from 5 mm-20 mm (mean: 8 mm). hTe distance of lung lesions from the nearest pleural surfaces ranged within 5 mm-30 mm (mean: 14 mm). All resections of lesions guided by the Hook-wire were successfully performed by VATS (success rate: 100%). hTe mean procedure time for the CT-guided Hook-wire localization was 10 min (range: 5 min-10 min). hTe mean procedure time for VATS wedge resection was 20 min (range: 15 min-40 min). hTe mean hospital time was 4 d (range: 3 d-6 d). hTe major complication of CT-guided Hook-wire localization was mild pneumothorax in 4 patients, but no one needed chest tube drain-age. Wedge resection was performed successfully in all cases. hTe dislocation of Hook-wire was found in only one patient dur-ing the operation, but the lesion was still successfully resected under VATS. Results of pathological examination of 16 mGGOs revealed 8 primary lung cancers and 8 nonspeciifc chronic inlfammations. Results of pathological examination of 4 pGGOs re-vealed 1 primary lung cancers, 1 atypical

  12. Are Modic changes related to outcomes in lumbar disc herniation patients treated with imaging-guided lumbar nerve root blocks?

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Cynthia K., E-mail: cynthia.peterson@balgrist.ch [Department of Radiology, Orthopaedic University Hospital Balgrist, University of Zürich (Switzerland); Pfirrmann, Christian W.A. [Department of Radiology, Orthopaedic University Hospital Balgrist, University of Zürich (Switzerland); Hodler, Jürg [Department of Radiology, University Hospital, University of Zürich (Switzerland)

    2014-10-15

    Objective: To compare outcomes after imaging-guided transforaminal lumbar nerve root blocks in MRI confirmed symptomatic disc herniation patients with and without Modic changes (MC). Methods: Consecutive adult patients with MRI confirmed symptomatic lumbar disc herniations and an imaging-guided lumbar nerve root block injection who returned an outcomes questionnaire are included. Numerical rating scale (NRS) pain data was collected prior to injection and 20–30 min after injection. NRS and overall improvement were assessed using the patient's global impression of change (PGIC) scale at 1 day, 1 week and 1 month post injection. The proportion of patients with and without MC on MRI as well as Modic I and Modic II was calculated. These groups were compared for clinically relevant ‘improvement’ using the Chi-squared test. Baseline and follow-up NRS scores were compared for the groups using the unpaired t-test. Results: 346 patients are included with MC present in 57%. A higher percentage of patients without MC reported ‘improvement’ and a higher percentage of patients with MC reported ‘worsening’ but this did not reach statistical significance. The numerical scores on the PGIC and NRS scales showed that patients with MC had significantly higher pain and worse overall improvement scores at 1 month (p = 0.048 and p = 0.03) and a significantly lower 1 month NRS change score (p = 0.04). Conclusions: Patients with MRI confirmed symptomatic lumbar disc herniations and MC report significantly lower levels of pain reduction after a lumbar nerve root block compared to patients without MC.

  13. Limited proteolysis and peptide mapping for comparability of biopharmaceuticals: An evaluation of repeatability, intra-assay precision and capability to detect structural change.

    Science.gov (United States)

    Perrin, Camille; Burkitt, Will; Perraud, Xavier; O'Hara, John; Jone, Carl

    2016-05-10

    The use of limited proteolysis followed by peptide mapping for the comparability of the higher-order structure of biopharmaceuticals was investigated. In this approach the proteolysis is performed under non-reducing and non-denaturing conditions, and the resulting peptide map is determined by the samples primary and higher order structures. This allows comparability of biopharmaceuticals to be made in terms of their higher order structure, using a method that is relatively simple to implement. The digestion of a monoclonal antibody under non-denaturing conditions was analyzed using peptide mapping, circular dichroism (CD) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). This allowed an optimal digestion time to be chosen. This method was then assessed for its ability to detect structural change using a monoclonal antibody, which had been subjected to a range of stresses; deglycosylation, mild denaturation and a batch that had failed specifications due to in-process reduction. The repeatability and inter-assay precision were assessed. It was demonstrated that the limited proteolysis peptide maps of the three stressed samples were significantly different to control samples and that the differences observed were consistent between the occasions when the assays were run. A combination of limited proteolysis and CD or SDS-PAGE analysis was shown to enhance the capacity of these techniques to detect structural change, which otherwise would not have been observed.

  14. Upending the social ecological model to guide health promotion efforts toward policy and environmental change.

    Science.gov (United States)

    Golden, Shelley D; McLeroy, Kenneth R; Green, Lawrence W; Earp, Jo Anne L; Lieberman, Lisa D

    2015-04-01

    Efforts to change policies and the environments in which people live, work, and play have gained increasing attention over the past several decades. Yet health promotion frameworks that illustrate the complex processes that produce health-enhancing structural changes are limited. Building on the experiences of health educators, community activists, and community-based researchers described in this supplement and elsewhere, as well as several political, social, and behavioral science theories, we propose a new framework to organize our thinking about producing policy, environmental, and other structural changes. We build on the social ecological model, a framework widely employed in public health research and practice, by turning it inside out, placing health-related and other social policies and environments at the center, and conceptualizing the ways in which individuals, their social networks, and organized groups produce a community context that fosters healthy policy and environmental development. We conclude by describing how health promotion practitioners and researchers can foster structural change by (1) conveying the health and social relevance of policy and environmental change initiatives, (2) building partnerships to support them, and (3) promoting more equitable distributions of the resources necessary for people to meet their daily needs, control their lives, and freely participate in the public sphere.

  15. 76 FR 59382 - Notice of Proposed Change to Section IV of the Virginia State Technical Guide

    Science.gov (United States)

    2011-09-26

    ...: 315, Herbaceous Weed Control, 338, Prescribed Burning, 340, Cover Crop, 342, Critical Area Planting... plan and install conservation practices. DATES: Comments will be received for a 30-day period... in Virginia will receive comments relative to the proposed changes. Following that period,...

  16. A Course Exploration: Guiding Instruction to Prepare Students as Change Agents in Educational Reform

    Science.gov (United States)

    Church, Kathy L.

    2010-01-01

    This article explores the premise of teacher identity development through course experiences directed at inquiry and social awareness. The course exploration examines the use of various strategies used to help promote educators as change agents. Pre-service students enrolled in a one-year master's program with teaching credential participated in a…

  17. Shared Governance in Times of Change: A Practical Guide for Universities and Colleges

    Science.gov (United States)

    Bahls, Steven S.

    2014-01-01

    Today's challenging higher education environment demands a new way of making decisions. Changing business models and methodologies for delivering academic programs present new opportunities (as well as risks) and call for innovative responses. This publication aims to "reboot" dialogues among boards, presidents, and faculties. It creates…

  18. Opening science the evolving guide on how the Internet is changing research, collaboration and scholarly publishing

    CERN Document Server

    Friesike, Sascha

    2014-01-01

    Modern information and communication technologies, together with a cultural upheaval within the research community, have profoundly changed research in nearly every aspect. Ranging from sharing and discussing ideas in social networks for scientists to new collaborative environments and novel publication formats, knowledge creation and dissemination as we know it is experiencing a vigorous shift towards increased transparency, collaboration and accessibility. Many assume that research workflows will change more in the next 20 years than they have in the last 200. This book provides researchers, decision makers, and other scientific stakeholders with a snapshot of the basics, the tools, and the underlying visions that drive the current scientific (r)evolution, often called ‘Open Science.’

  19. Resilience-based perspectives to guiding high-nature-value farmland through socioeconomic change

    DEFF Research Database (Denmark)

    Plieninger, Tobias; Bieling, Claudia

    2013-01-01

    Global environmental challenges require approaches that integrate biodiversity conservation, food production, and livelihoods at landscape scales. We reviewed the approach of conserving biodiversity on "high-nature-value" (HNV) farmland, covering 75 million ha in Europe, from a resilience...... perspective. Despite growing recognition in natural resource policies, many HNV farmlands have vanished, and the remaining ones are vulnerable to socioeconomic changes. Using landscapelevel cases across Europe, we considered the following social-ecological system properties and components...

  20. A Saliency Guided Semi-Supervised Building Change Detection Method for High Resolution Remote Sensing Images.

    Science.gov (United States)

    Hou, Bin; Wang, Yunhong; Liu, Qingjie

    2016-08-27

    Characterizations of up to date information of the Earth's surface are an important application providing insights to urban planning, resources monitoring and environmental studies. A large number of change detection (CD) methods have been developed to solve them by utilizing remote sensing (RS) images. The advent of high resolution (HR) remote sensing images further provides challenges to traditional CD methods and opportunities to object-based CD methods. While several kinds of geospatial objects are recognized, this manuscript mainly focuses on buildings. Specifically, we propose a novel automatic approach combining pixel-based strategies with object-based ones for detecting building changes with HR remote sensing images. A multiresolution contextual morphological transformation called extended morphological attribute profiles (EMAPs) allows the extraction of geometrical features related to the structures within the scene at different scales. Pixel-based post-classification is executed on EMAPs using hierarchical fuzzy clustering. Subsequently, the hierarchical fuzzy frequency vector histograms are formed based on the image-objects acquired by simple linear iterative clustering (SLIC) segmentation. Then, saliency and morphological building index (MBI) extracted on difference images are used to generate a pseudo training set. Ultimately, object-based semi-supervised classification is implemented on this training set by applying random forest (RF). Most of the important changes are detected by the proposed method in our experiments. This study was checked for effectiveness using visual evaluation and numerical evaluation.

  1. Volume-of-change cone-beam CT for image-guided surgery

    Science.gov (United States)

    Lee, Junghoon; Webster Stayman, J.; Otake, Yoshito; Schafer, Sebastian; Zbijewski, Wojciech; Khanna, A. Jay; Prince, Jerry L.; Siewerdsen, Jeffrey H.

    2012-08-01

    C-arm cone-beam CT (CBCT) can provide intraoperative 3D imaging capability for surgical guidance, but workflow and radiation dose are the significant barriers to broad utilization. One main reason is that each 3D image acquisition requires a complete scan with a full radiation dose to present a completely new 3D image every time. In this paper, we propose to utilize patient-specific CT or CBCT as prior knowledge to accurately reconstruct the aspects of the region that have changed by the surgical procedure from only a sparse set of x-rays. The proposed methods consist of a 3D-2D registration between the prior volume and a sparse set of intraoperative x-rays, creating digitally reconstructed radiographs (DRRs) from the registered prior volume, computing difference images by subtracting DRRs from the intraoperative x-rays, a penalized likelihood reconstruction of the volume of change (VOC) from the difference images, and finally a fusion of VOC reconstruction with the prior volume to visualize the entire surgical field. When the surgical changes are local and relatively small, the VOC reconstruction involves only a small volume size and a small number of projections, allowing less computation and lower radiation dose than is needed to reconstruct the entire surgical field. We applied this approach to sacroplasty phantom data obtained from a CBCT test bench and vertebroplasty data with a fresh cadaver acquired from a C-arm CBCT system with a flat-panel detector. The VOCs were reconstructed from a varying number of images (10-66 images) and compared to the CBCT ground truth using four different metrics (mean squared error, correlation coefficient, structural similarity index and perceptual difference model). The results show promising reconstruction quality with structural similarity to the ground truth close to 1 even when only 15-20 images were used, allowing dose reduction by the factor of 10-20.

  2. Guide to the Changes between the 2009 and 2012 International Energy Conservation Code

    Energy Technology Data Exchange (ETDEWEB)

    Mapes, Terry S.; Conover, David R.

    2012-05-31

    The International Code Council (ICC) published the 2012 International Energy Conservation Code{reg_sign} (IECC) in early 2012. The 2012 IECC is based on revisions, additions, and deletions to the 2009 IECC that were considered during the ICC code development process conducted in 2011. Solid vertical lines, arrows, or asterisks printed in the 2012 IECC indicate where revisions, deletions, or relocations of text respectively were made to 2009 IECC. Although these marginal markings indicate where changes have been made to the code, they do not provide any further guidance, leaving the reader to consult and compare the 2009 and 2012 IECC for more detail.

  3. Use of an Innovative Personality-Mindset Profiling Tool to Guide Culture-Change Strategies among Different Healthcare Worker Groups.

    Directory of Open Access Journals (Sweden)

    M Lindsay Grayson

    Full Text Available Important culture-change initiatives (e.g. improving hand hygiene compliance are frequently associated with variable uptake among different healthcare worker (HCW categories. Inherent personality differences between these groups may explain change uptake and help improve future intervention design.We used an innovative personality-profiling tool (ColourGrid® to assess personality differences among standard HCW categories at five large Australian hospitals using two data sources (HCW participant surveys [PS] and generic institution-wide human resource [HR] data to: a compare the relative accuracy of these two sources; b identify differences between HCW groups and c use the observed profiles to guide design strategies to improve uptake of three clinically-important initiatives (improved hand hygiene, antimicrobial stewardship and isolation procedure adherence.Results from 34,243 HCWs (HR data and 1045 survey participants (PS data suggest that HCWs were different from the general population, displaying more individualism, lower power distance, less uncertainty avoidance and greater cynicism about advertising messages. HR and PS data were highly concordant in identifying differences between the three key HCW categories (doctors, nursing/allied-health, support services and predicting appropriate implementation strategies. Among doctors, the data suggest that key messaging should differ between full-time vs part-time (visiting senior medical officers (SMO, VMO and junior hospital medical officers (HMO, with SMO messaging focused on evidence-based compliance, VMO initiatives emphasising structured mandatory controls and prestige loss for non-adherence, and for HMOs focusing on leadership opportunity and future career risk for non-adherence.Compared to current standardised approaches, targeted interventions based on personality differences between HCW categories should result in improved infection control-related culture-change uptake. Personality

  4. EDITORIAL: Precision proteins Precision proteins

    Science.gov (United States)

    Demming, Anna

    2010-06-01

    Since the birth of modern day medicine, during the times of Hippocrates in ancient Greece, the profession has developed from the rudimentary classification of disease into a rigorous science with an inspiring capability to treat and cure. Scientific methodology has distilled clinical diagnostic tools from the early arts of prognosis, which used to rely as much on revelation and prophecy, as intuition and judgement [1]. Over the past decade, research into the interactions between proteins and nanosystems has provided some ingenious and apt techniques for delving into the intricacies of anatomical systems. In vivo biosensing has emerged as a vibrant field of research, as much of medical diagnosis relies on the detection of substances or an imbalance in the chemicals in the body. The inherent properties of nanoscale structures, such as cantilevers, make them well suited to biosensing applications that demand the detection of molecules at very low concentrations. Measurable deflections in cantilevers functionalised with antibodies provide quantitative indicators of the presence of specific antigens when the two react. Such developments have roused mounting interest in the interactions of proteins with nanostructures, such as carbon nanotubes [3], which have demonstrated great potential as generic biomarkers. Plasmonic properties are also being exploited in sensing applications, such as the molecular sentinel recently devised by researchers in the US. The device uses the plasmonic properties of a silver nanoparticle linked to a Raman labelled hairpin DNA probe to signal changes in the probe geometry resulting from interactions with substances in the environment. Success stories so far include the detection of two specific genes associated with breast cancer [4]. A greater understanding of how RNA interference regulates gene expression has highlighted the potential of using this natural process as another agent for combating disease in personalized medicine. However, the

  5. Game playbooks: tools to guide multidisciplinary teams in developing videogame-based behavior change interventions.

    Science.gov (United States)

    Duncan, Lindsay R; Hieftje, Kimberly D; Culyba, Sabrina; Fiellin, Lynn E

    2014-03-01

    As mobile technologies and videogaming platforms are becoming increasingly prevalent in the realm of health and healthcare, so are the opportunities to use these resources to conduct behavioral interventions. The creation and empirical testing of game style interventions, however, is challenged by the requisite collaboration of multidisciplinary teams, including researchers and game developers who have different cultures, terminologies, and standards of evidence. Thus, traditional intervention development tools such as logic models and intervention manuals may need to be augmented by creating what we have termed "Game Playbooks" which are intervention guidebooks that are created by, understood by, and acceptable to all members of the multidisciplinary game development team. The purpose of this paper is to describe the importance and content of a Game Playbook created to aide in the development of a videogame intervention designed specifically for health behavior change in young teens as well as the process for creating such a tool. We draw on the experience of our research and game design team to describe the critical components of the Game Playbook and the necessity of creating such a tool.

  6. Acculturation of Greek Americans: Change and continuity in cognitive schemas guiding intimate relationships.

    Science.gov (United States)

    Koutrelakos, James

    2004-04-01

    The study compares Greek Americans to Greeks and to third-generation white Americans in their endorsement of two cognitive schemas guiding intimate relationships. Greek Americans were more rejecting of low self-disclosure in intimate relationships than were Greeks but did not differ from them on how strongly they advocated sacrificing the self for one's partner. By contrast, Greek Americans did not differ from Americans in their rejection of low self-disclosure and more strongly endorsed self-sacrifice in intimate relationships than did Americans. These findings were interpreted as indicating that Greek Americans have acculturated to a more individualistic orientation in terms of self-disclosure while maintaining a collectivistic orientation regarding self-sacrifice in intimate relationships. Respondents' age, cultural group, and whether they were college students or professionals interacted with how strongly individuals rejected low self-disclosure and showed that age and status differences were more pronounced between rather than within the three cultural groups. It revealed that the initial finding, showing that Greeks and Americans differed, was based on the scores of students; professionals, with one exception, did not differ in their disagreement with low self-disclosure, regardless of their age and cultural group. The exception was the older Greek American professional subgroup, whose stronger disagreement with low self-disclosure may be an overreaction to the acculturation process. Age and status differences were not significant in the American group, while there was a pattern in Greece for professionals to reject low self-disclosure more strongly than did students. Women were more rejecting of both low self-disclosure and self-sacrifice in intimate relationships than were men. Older women most strongly disagreed with the self-sacrifice principle and older men adhered to it more strongly with increasing age. Cette étude compare des Américains grecs à des

  7. Design and Evaluation of a Digital Module with Guided Peer Feedback for Student Learning Biotechnology and Molecular Life Sciences, Attitudinal Change, and Satisfaction

    Science.gov (United States)

    Noroozi, Omid; Mulder, Martin

    2017-01-01

    This study aims to investigate the impacts of a digital learning module with guided peer feedback on students' domain-specific knowledge gain and their attitudinal change in the field of biotechnology and molecular life sciences. The extent to which the use of this module is appreciated by students is studied as well. A pre-test, post-test design…

  8. Recent Changes in UC Admissions Policies. Parent/Student Guide = Unos cambios recientes en los reglamentos de ingreso de la universidad de California. Guia de padres/estudiantes.

    Science.gov (United States)

    EdSource, Inc., Palo Alto, CA.

    This parent/student guide describes recent changes in admissions policies at the University of California (UC). Traditionally, UC admitted the top 12.5% of high school graduating seniors, but beginning in 2001, the top 4% of students in the graduating class of every high school are eligible if they have completed 11 specific "a-f"…

  9. Understanding groundwater - students' pre-conceptions and conceptual change by means of a theory-guided multimedia learning program

    Science.gov (United States)

    Unterbruner, Ulrike; Hilberg, Sylke; Schiffl, Iris

    2016-06-01

    Education on the subject of groundwater is crucial for sustainability. Nevertheless, international studies with students across different age groups have shown that the basic hydrogeological concept of groundwater defined as water within porous and permeable rocks is not an established everyday notion. Drawing from international research, a multimedia learning program Zwischen Regenwolke und Wasserhahn (between the rain cloud and the tap) was developed, which incorporates specific insights from the fields of conceptual change research, multimedia research, and the model of educational reconstruction. The effectiveness of the learning program was ascertained by means of two studies with Austrian seventh grade pupils as well as teacher-training students from the fields of biology and geography in order to ascertain the effectiveness of the learning program. Using a quasi-experimental research design, the participants' conceptions and knowledge of groundwater were determined in a pre- and post-test. The pupils and students greatly benefitted from working through the learning software independently. Their knowledge of groundwater increased significantly compared to the control group and there was a highly significant increase in the number of scientifically correct notions of groundwater. The acceptance of the program was also generally very high. The results indicate that theory-guided multimedia learning programs can play an important role in the transfer of research results to classroom settings, especially in science education.

  10. Guide to Behavior Change

    Science.gov (United States)

    ... long-term challenge. Weight can affect a person's self-esteem. Excess weight is highly visible and evokes some ... Skip footer links and go to content Twitter Facebook YouTube Google+ SITE INDEX | ACCESSIBILITY | PRIVACY STATEMENT | FOIA | ...

  11. MP users guide

    CERN Document Server

    Brent, Richard P

    2010-01-01

    MP is a package of ANSI Standard Fortran (ANS X3.9-1966) subroutines for performing multiple-precision floating-point arithmetic and evaluating elementary and special functions. The subroutines are machine independent and the precision is arbitrary, subject to storage limitations. The User's Guide describes the routines and their calling sequences, example and test programs, use of the Augment precompiler, and gives installation instructions for the package.

  12. Precise U-Pb dating of Cenozoic tropical reef carbonates: Linking the evolution of Cenozoic Caribbean reef carbonates to climatic and environmental changes.

    Science.gov (United States)

    Silva-Tamayo, J. C.; Ducea, M.; Cardona, A.; Montes, C.; Rincon, D.; Machado, A.; Flores, A.; Sial, A.; Pardo, A.; Niño, H.; Ramirez, V.; Jaramillo, C.; Zapata, P.; Barrios, L.; Rosero, S.; Bayona, G.; Zapata, V.

    2012-04-01

    rapid anthropogenic CO2 release to the atmosphere on reef areas. Here we report precise U-Pb ages of several Cenozoic Caribbean-tropical reef carbonate successions along the SE Circum-Caribbean Region from which major temporal variations in the reef carbonate factories, structure and ecology are related to major climate/environmental changes. Calcareous algae are the principal calcifying reef builders along the SE Circum-Caribbean during the Paleocene-middle Oligocene interval, a period of predominant high atmospheric pCO2 and OA. Calcareous algae persisted as the main calcifying reef builders until the late Oligocene when atmospheric pCO2 levels dropped, allowing the onset of global icehouse conditions and the appearance of corals as the main calcifying reef builders along the SE Circum-Caribbean. Coral reefs would have dominated until the middle Miocene, when a new period of calcareous algae reefs occurred along the Caribbean, coinciding with the Miocene thermal optimum in mid-latitude areas (i.e. the Mediterranean). Coral reef carbonates dominated since the Pliocene. From the data presented here we suggest that calcareous algae dominated were the main calcifying reef builders during periods of warm temperatures and pronounced environmental change in the tropical seas (i.e. OA). Corals would have conversely dominated as main calcifying reef builders during periods of optimal tropical climatic/environmental conditions. Comparisons between this geologic conditions and data for the period 1984-2006 in the Caribbean11 suggest that the transition from corals towards calcareous algae is repeating again. 1.Zachos et al., Science Mag. 292 (2001) 2.Zachos et al., Science Mag. 308 (2005) 3.Haug et al., Geology 29 (2001) 4.Jain and Collins, Marine Micropaleo. 62 (2007) 5.Merinco et al., Nature 452 (2008) 6.O'Dea et al., Proc. Nat. Acad. Sci. 104 (2007) 7.Jhonson et al., Palaios 24(2009) 8.Pagani et al., Nature 460 (2007) 9.Cohen et al., Journ. Geolog. Society 164 (2009) 10

  13. Corneal changes following collagen cross linking and simultaneous topography guided photoablation with collagen cross linking for keratoconus

    Directory of Open Access Journals (Sweden)

    Prema Padmanabhan

    2014-01-01

    Full Text Available Purpose: To compare the outcome of Collagen cross-linking (CXL with that following topography-guided customized ablation treatment (T-CAT with simultaneous CXL in eyes with progressive keratoconus. Materials and Methods: This was a prospective, non-randomized single centre study of 66 eyes with progressive keratoconus. Of these, 40 eyes underwent CXL and 26 eyes underwent T-CAT + CXL. The refractive, topographic, tomographic and aberrometric changes measured at baseline, 1, 3 and 6 months post-operatively were compared between both groups. Results: After a mean follow-up of 7.7 ± 1.3 months, the mean retinoscopic cylinder decreased by 1.02 ± 3.16 D in the CXL group ( P = 0.1 and 2.87 ± 3.22 D in the T-CAT + CXL group ( P = 0.04. The Best corrected visual acuity increased by 2 lines or more in 10% of eyes in the CXL group and in 23.3% of eyes in the T-CAT + CXL group. The mean steepest-K reduced by 0.40 ± 3.71 D ( P = 0.77 in the CXL group and by 2.91 ± 2.01D ( P = 0.03 in the T-CAT + CXL group. The sag factor and surface asymmetry index showed no significant change in the CXL group but reduced by 3.59 ± 5.94 D ( P = 0.01 and 0.72 ± 1.18 ( P = 0.02 respectively in the T-CAT + CXL group. There was a significant increase in the highest posterior corneal elevation in both groups (9.57 ± 14.93 μ in the CXL group and 7.85 ± 9.25 μ in the T-CAT + CXL group, P ≤ 0.001 for both. There was significantly greater reduction of mean coma ( P < 0.001 and mean higher-order aberrations ( P = 0.01 following T-CAT + CXL compared to CXL. Conclusions: CAT + CXL is an effective approach to confer biomechanical stability and to improve the corneal contour in eyes with keratoconus and results in better refractive, topographic and aberrometric outcomes than CXL alone.

  14. Precision performance lamp technology

    Science.gov (United States)

    Bell, Dean A.; Kiesa, James E.; Dean, Raymond A.

    1997-09-01

    A principal function of a lamp is to produce light output with designated spectra, intensity, and/or geometric radiation patterns. The function of a precision performance lamp is to go beyond these parameters and into the precision repeatability of performance. All lamps are not equal. There are a variety of incandescent lamps, from the vacuum incandescent indictor lamp to the precision lamp of a blood analyzer. In the past the definition of a precision lamp was described in terms of wattage, light center length (LCL), filament position, and/or spot alignment. This paper presents a new view of precision lamps through the discussion of a new segment of lamp design, which we term precision performance lamps. The definition of precision performance lamps will include (must include) the factors of a precision lamp. But what makes a precision lamp a precision performance lamp is the manner in which the design factors of amperage, mscp (mean spherical candlepower), efficacy (lumens/watt), life, not considered individually but rather considered collectively. There is a statistical bias in a precision performance lamp for each of these factors; taken individually and as a whole. When properly considered the results can be dramatic to the system design engineer, system production manage and the system end-user. It can be shown that for the lamp user, the use of precision performance lamps can translate to: (1) ease of system design, (2) simplification of electronics, (3) superior signal to noise ratios, (4) higher manufacturing yields, (5) lower system costs, (6) better product performance. The factors mentioned above are described along with their interdependent relationships. It is statistically shown how the benefits listed above are achievable. Examples are provided to illustrate how proper attention to precision performance lamp characteristics actually aid in system product design and manufacturing to build and market more, market acceptable product products in the

  15. Precision Clock Evaluation Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Tests and evaluates high-precision atomic clocks for spacecraft, ground, and mobile applications. Supports performance evaluation, environmental testing,...

  16. Trees as huge flowers and flowers as oversized floral guides: the role of floral color change and retention of old flowers in Tibouchina pulchra

    Directory of Open Access Journals (Sweden)

    Vinícius Lourenço Garcia Brito

    2015-05-01

    Full Text Available Floral color changes and retention of old flowers are frequently combined phenomena restricted to the floral guide or single flowers in few-flowered inflorescences. They are thought to increase the attractiveness over long distances and to direct nearby pollinators towards the rewarding flowers. In Tibouchina pulchra, a massively flowering tree, the whole flower changes its color during anthesis. On the first day, the flowers are white and on the next three days, they change to pink. This creates a new large-scale color pattern in which the white pre-changed flowers contrast against the pink post-changed ones over the entire tree. We describe the spectral characteristics of floral colors of T. pulchra and test bumblebees´ response to this color pattern when viewed at different angles (simulating long and short distances. The results indicated the role of different color components in bumblebee attraction and the possible scenario in which this flower color pattern has evolved. We tested bumblebees´ preference for simulated trees with 75% pink and 25% white flowers resembling the color patterns of T. pulchra, and trees with green leaves and pink flowers (control in long-distance approach. We also compared an artificial setting with three pink flowers and one white flower (T. pulchra model against four pink flowers with white floral guides (control in short-distance approach. Bumblebees spontaneously preferred the simulated T. pulchra patterns in both approaches despite similar rewards. Moreover, in short distances, pollinator visits to peripheral, non-rewarding flowers occurred only half as frequently in the simulated T. pulchra when compared to the control. Thefore, this exceptional floral color change and the retention of old flowers in T. pulchra favors the attraction of pollinators over long distances in a deception process while it honestly directs them towards the rewarding flowers at short distances possibly exploring their innate color

  17. Promotion Guide – A guide for career reviews

    CERN Multimedia

    Staff Association

    2017-01-01

    On 8 February, the Standing Concertation Committee (SCC) approved the Promotion Guide, subtitled “A guide for career reviews”. The English version is already published on the HR website. This Promotion Guide is not very different from the Career Path Guide which it replaces following the implementation of the new career structure with benchmark jobs and grades. Structure The guide is composed of three parts: Section I – Introduction revisits the reference documents: the Staff Rules and Regulations (S&R) and the Administrative Circular No. 26 (AC 26). In the Staff Rules and Regulations, the term promotion is defined as a change of grade1 and in Administrative Circular No. 26, the Promotion Guide is referenced under paragraph 452. The objective of the Promotion Guide is laid out in Section I: “The Promotion Guide defines the criteria to be used as a reference for career reviews with a view to a potential promotion”. However, this guide do...

  18. How will global warming affect my world? A simplified guide to the IPCC's 'Climate Change 2001. Impacts, Adaptation and Vulnerability'

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-11-15

    Global warming is already changing the world around us in ways that researchers can measure and quantify. Such changes will become more and more evident with each passing decade. Although cutting greenhouse gas emissions in order to minimize future climate change must be our top priority, we must also prepare to respond to impacts that our past emissions now make inevitable. People everywhere need to understand how climate change is going to affect them and what they can do to cope. Fortunately, the Working Group II of the WMO/UNEP Intergovernmental Panel on Climate Change (IPCC) has assessed what researchers have learned about expected impacts and how to adapt to them. Its findings are presented in a comprehensive publication entitled 'Climate Change 2001: Impacts, Adaptation and Vulnerability', which is part of the IPCC's Third Assessment Report. This Report also includes volumes on the causes of climate change and on options for limiting greenhouse emissions. This simplified guide presents the highly technical findings of Working Group II in everyday language. It is not an official document and has been neither approved nor accepted by the IPCC. Instead, it seeks to make the hundreds of pages of detailed text contained in the volume on 'Impacts, Adaptation and Vulnerability' more accessible to a broader audience. I encourage readers seeking further information to refer to the original publications and the IPCC's web site.

  19. The Scheme and the Preliminary Test of Object-Oriented Simultaneous 3D Geometric and Physical Change Detection Using GIS-guided Knowledge

    Directory of Open Access Journals (Sweden)

    Chang LI

    2013-07-01

    Full Text Available Current methods of remotely sensed image change detection almost assume that the DEM of the surface objects do not change. However, for the geological disasters areas (such as: landslides, mudslides and avalanches, etc., this assumption does not hold. And the traditional approach is being challenged. Thus, a new theory for change detection needs to be extended from two-dimensional (2D to three-dimensional (3D urgently. This paper aims to present an innovative scheme for change detection method, object-oriented simultaneous three-dimensional geometric and physical change detection (OOS3DGPCD using GIS-guided knowledge. This aim will be reached by realizing the following specific objectives: a to develop a set of automatic multi-feature matching and registration methods; b to propose an approach for simultaneous detecting 3D geometric and physical attributes changes based on the object-oriented strategy; c to develop a quality control method for OOS3DGPCD; d to implement the newly proposed OOS3DGPCD method by designing algorithms and developing a prototype system. For aerial remotely sensed images of YingXiu, Wenchuan, preliminary experimental results of 3D change detection are shown so as to verify our approach.

  20. Precision Teaching: An Introduction.

    Science.gov (United States)

    West, Richard P.; And Others

    1990-01-01

    Precision teaching is introduced as a method of helping students develop fluency or automaticity in the performance of academic skills. Precision teaching involves being aware of the relationship between teaching and learning, measuring student performance regularly and frequently, and analyzing the measurements to develop instructional and…

  1. Precision Teaching: By Teachers for Children.

    Science.gov (United States)

    Lindsley, Ogden R.

    1990-01-01

    The founding policies of precision teaching are discussed: monitor frequency daily, use self-recording, use standard charts to display major changes, and accept that the child knows best how he or she learns. Contributions of teachers that have furthered the development of precision teaching are documented. (JDD)

  2. Precision constraints on extra fermion generations.

    Science.gov (United States)

    Erler, Jens; Langacker, Paul

    2010-07-16

    There has been recent renewed interest in the possibility of additional fermion generations. At the same time there have been significant changes in the relevant electroweak precision constraints, in particular, in the interpretation of several of the low energy experiments. We summarize the various motivations for extra families and analyze them in view of the latest electroweak precision data.

  3. Climate Change in the Social Studies Classroom: A "Why" and "How To" Guide Using the C3 Framework

    Science.gov (United States)

    Kumler, Lori M.; Vosburg-Bluem, Bethany

    2014-01-01

    Weather phenomena across the United States have provided heightened attention to climate change in headlines such as "Heavy Rain and Floods: The 'New Normal' with Climate Change?" ("Christian Science Monitor," Aug. 14, 2014); "Delay Action on Climate Change by 10 Years and Costs Rocket 40%"…

  4. Assessing the beginning to end-of-mission sensitivity change of the PREcision MOnitor Sensor total solar irradiance radiometer (PREMOS/PICARD)

    Science.gov (United States)

    Ball, William T.; Schmutz, Werner; Fehlmann, André; Finsterle, Wolfgang; Walter, Benjamin

    2016-08-01

    The switching of the total solar irradiance (TSI) backup radiometer (PREMOS-B) to a primary role for 2 weeks at the end of the PICARD mission provides a unique opportunity to test the fundamental hypothesis of radiometer experiments in space, which is that the sensitivity change of instruments due to the space environment is identical for the same instrument type as a function of solar-exposure time of the instruments. We verify this hypothesis for the PREMOS TSI radiometers within the PREMOS experiment on the PICARD mission. We confirm that the sensitivity change of the backup instrument, PREMOS-B, is similar to that of the identically-constructed primary radiometer, PREMOS-A. The extended exposure of the backup instrument at the end of the mission allows for the assessment, with an uncertainty estimate, of the sensitivity change of the primary radiometer from the beginning of the PICARD mission compared to the end, and of the degradation of the backup over the mission. We correct six sets of PREMOS-B observations connecting October 2011 with February 2014, using six ratios from simultaneous PREMOS-A and PREMOS-B exposures during the first days of PREMOS-A operation in 2010. These ratios are then used, without indirect estimates or assumptions, to evaluate the stability of SORCE/TIM and SOHO/VIRGO TSI measurements, which have both operated for more than a decade and now show different trends over the time span of the PICARD mission, namely from 2010 to 2014. We find that by February 2014 relative to October 2011 PREMOS-B supports the SORCE/TIM TSI time evolution, which in May 2014 relative to October 2011 is ~0.11 W m-2, or ~84 ppm, higher than SOHO/VIRGO. Such a divergence between SORCE/TIM and SOHO/VIRGO over this period is a significant fraction of the estimated decline of 0.2 W m-2 between the solar minima of 1996 and 2008, and questions the reliability of that estimated trend. Extrapolating the uncertainty indicated by the disagreement of SORCE/TIM and PREMOS

  5. Assessing the beginning to end-of-mission sensitivity change of the PREcision MOnitor Sensor total solar irradiance radiometer (PREMOS/PICARD

    Directory of Open Access Journals (Sweden)

    Ball William T.

    2016-01-01

    Full Text Available The switching of the total solar irradiance (TSI backup radiometer (PREMOS-B to a primary role for 2 weeks at the end of the PICARD mission provides a unique opportunity to test the fundamental hypothesis of radiometer experiments in space, which is that the sensitivity change of instruments due to the space environment is identical for the same instrument type as a function of solar-exposure time of the instruments. We verify this hypothesis for the PREMOS TSI radiometers within the PREMOS experiment on the PICARD mission. We confirm that the sensitivity change of the backup instrument, PREMOS-B, is similar to that of the identically-constructed primary radiometer, PREMOS-A. The extended exposure of the backup instrument at the end of the mission allows for the assessment, with an uncertainty estimate, of the sensitivity change of the primary radiometer from the beginning of the PICARD mission compared to the end, and of the degradation of the backup over the mission. We correct six sets of PREMOS-B observations connecting October 2011 with February 2014, using six ratios from simultaneous PREMOS-A and PREMOS-B exposures during the first days of PREMOS-A operation in 2010. These ratios are then used, without indirect estimates or assumptions, to evaluate the stability of SORCE/TIM and SOHO/VIRGO TSI measurements, which have both operated for more than a decade and now show different trends over the time span of the PICARD mission, namely from 2010 to 2014. We find that by February 2014 relative to October 2011 PREMOS-B supports the SORCE/TIM TSI time evolution, which in May 2014 relative to October 2011 is ~0.11 W m−2, or ~84 ppm, higher than SOHO/VIRGO. Such a divergence between SORCE/TIM and SOHO/VIRGO over this period is a significant fraction of the estimated decline of 0.2 W m−2 between the solar minima of 1996 and 2008, and questions the reliability of that estimated trend. Extrapolating the uncertainty indicated by the

  6. Precision volume measurement system.

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erin E.; Shugard, Andrew D.

    2004-11-01

    A new precision volume measurement system based on a Kansas City Plant (KCP) design was built to support the volume measurement needs of the Gas Transfer Systems (GTS) department at Sandia National Labs (SNL) in California. An engineering study was undertaken to verify or refute KCP's claims of 0.5% accuracy. The study assesses the accuracy and precision of the system. The system uses the ideal gas law and precise pressure measurements (of low-pressure helium) in a temperature and computer controlled environment to ratio a known volume to an unknown volume.

  7. New concepts and materials for the manufacturing of MR-compatible guide wires.

    Science.gov (United States)

    Brecher, Christian; Emonts, Michael; Brack, Alexander; Wasiak, Christian; Schütte, Adrian; Krämer, Nils; Bruhn, Robin

    2014-04-01

    This paper shows the development of a new magnetic resonance imaging (MRI)-compatible guide wire made from fiber-reinforced plastics. The basic material of the developed guide wire is manufactured using a specially developed micro-pullwinding technology, which allows the adjustment of tensile, bending, and torsional stiffness independent from each other. Additionally, the micro-pullwinding technology provides the possibility to vary the stiffness along the length of the guide wire in a continuous process. With the possibilities of this technology, the mechanical properties of the guide wire were precisely adjusted for the intended usage in MRI-guided interventions. The performance of the guide wire regarding the mechanical properties was investigated. It could be shown, that the mechanical properties could be changed independently from each other by varying the process parameters. Especially, the torsional stiffness could be significantly improved with only a minor influence on bending and tensile properties. The precise influence of the variation of the winding angle on the mechanical and geometrical properties has to be further investigated. The usability of the guide wire as well as its visibility in MRI was investigated by radiologists. With the micro-pullwinding technology, a continuous manufacturing technique for highly stressable, MRI-safe profiles is available and can be the trigger for a new class of medical devices.

  8. Precision Measurement in Biology

    Science.gov (United States)

    Quake, Stephen

    Is biology a quantitative science like physics? I will discuss the role of precision measurement in both physics and biology, and argue that in fact both fields can be tied together by the use and consequences of precision measurement. The elementary quanta of biology are twofold: the macromolecule and the cell. Cells are the fundamental unit of life, and macromolecules are the fundamental elements of the cell. I will describe how precision measurements have been used to explore the basic properties of these quanta, and more generally how the quest for higher precision almost inevitably leads to the development of new technologies, which in turn catalyze further scientific discovery. In the 21st century, there are no remaining experimental barriers to biology becoming a truly quantitative and mathematical science.

  9. Laser precision microfabrication

    CERN Document Server

    Sugioka, Koji; Pique, Alberto

    2010-01-01

    Miniaturization and high precision are rapidly becoming a requirement for many industrial processes and products. As a result, there is greater interest in the use of laser microfabrication technology to achieve these goals. This book composed of 16 chapters covers all the topics of laser precision processing from fundamental aspects to industrial applications to both inorganic and biological materials. It reviews the sate of the art of research and technological development in the area of laser processing.

  10. Precision oncology: origins, optimism, and potential.

    Science.gov (United States)

    Prasad, Vinay; Fojo, Tito; Brada, Michael

    2016-02-01

    Imatinib, the first and arguably the best targeted therapy, became the springboard for developing drugs aimed at molecular targets deemed crucial to tumours. As this development unfolded, a revolution in the speed and cost of genetic sequencing occurred. The result--an armamentarium of drugs and an array of molecular targets--set the stage for precision oncology, a hypothesis that cancer treatment could be markedly improved if therapies were guided by a tumour's genomic alterations. Drawing lessons from the biological basis of cancer and recent empirical investigations, we take a more measured view of precision oncology's promise. Ultimately, the promise is not our concern, but the threshold at which we declare success. We review reports of precision oncology alongside those of precision diagnostics and novel radiotherapy approaches. Although confirmatory evidence is scarce, these interventions have been widely endorsed. We conclude that the current path will probably not be successful or, at a minimum, will have to undergo substantive adjustments before it can be successful. For the sake of patients with cancer, we hope one form of precision oncology will deliver on its promise. However, until confirmatory studies are completed, precision oncology remains unproven, and as such, a hypothesis in need of rigorous testing.

  11. A field guide to real-time culture change: just "rolling out" a training program won't cut it.

    Science.gov (United States)

    Kusy, Mitchell; Holloway, Elizabeth L

    2014-01-01

    Presented as a representative case of how to handle the disruptive behaviors of professionals in healthcare, this article describes the strategies of a systems approach with a five-phase model for culture change. The "large-scale, real-time" culture change process, based on our own evidence-based research on toxic behaviors and the research of others, has been demonstrated to be more effective than one-on-one feedback to change these behaviors. The real-time approach has been applied to other organizational situations--strategy formulation, change management, or service improvement--with more sustainable effects than simply training alone. This article will help your organization with four outcomes: understanding the rationale for a five-phase model for cultural change, describing the advantages of a real-time versus nonreal-time approach to change, identifying the how-to's for application within a systems approach, and articulating a clear evaluation process to sustain successful organizational culture change.

  12. Behavioral analysis of signals that guide learned changes in the amplitude and dynamics of the vestibulo-ocular reflex

    Science.gov (United States)

    Raymond, J. L.; Lisberger, S. G.

    1996-01-01

    We characterized the dependence of motor learning in the monkey vestibulo-ocular reflex (VOR) on the duration, frequency, and relative timing of the visual and vestibular stimuli used to induce learning. The amplitude of the VOR was decreased or increased through training with paired head and visual stimulus motion in the same or opposite directions, respectively. For training stimuli that consisted of simultaneous pulses of head and target velocity 80-1000 msec in duration, brief stimuli caused small changes in the amplitude of the VOR, whereas long stimuli caused larger changes in amplitude as well as changes in the dynamics of the reflex. When the relative timing of the visual and vestibular stimuli was varied, brief image motion paired with the beginning of a longer vestibular stimulus caused changes in the amplitude of the reflex alone, but the same image motion paired with a later time in the vestibular stimulus caused changes in the dynamics as well as the amplitude of the VOR. For training stimuli that consisted of sinusoidal head and visual stimulus motion, low-frequency training stimuli induced frequency-selective changes in the VOR, as reported previously, whereas high-frequency training stimuli induced changes in the amplitude of the VOR that were more similar across test frequency. The results suggest that there are at least two distinguishable components of motor learning in the VOR. One component is induced by short-duration or high-frequency stimuli and involves changes in only the amplitude of the reflex. A second component is induced by long-duration or low-frequency stimuli and involves changes in the amplitude and dynamics of the VOR.

  13. Una Nueva IDEA: Una Guia para Padres acerca de los Cambios en la Ley de Educacion Especial para Ninos con Incapacidades (A New IDEA: A Parent's Guide to the Changes in Social Education Law for Children with Disabilities).

    Science.gov (United States)

    Seltzer, Tammy

    This guide for parents, in Spanish, explains the changes in the federal special education law resulting from the 1997 amendments to the Individuals with Disabilities Education Act (IDEA). Changes related to the parent's role in decisions about the child's education and in how schools can discipline special education students are highlighted. A…

  14. Estimating sparse precision matrices

    Science.gov (United States)

    Padmanabhan, Nikhil; White, Martin; Zhou, Harrison H.; O'Connell, Ross

    2016-08-01

    We apply a method recently introduced to the statistical literature to directly estimate the precision matrix from an ensemble of samples drawn from a corresponding Gaussian distribution. Motivated by the observation that cosmological precision matrices are often approximately sparse, the method allows one to exploit this sparsity of the precision matrix to more quickly converge to an asymptotic 1/sqrt{N_sim} rate while simultaneously providing an error model for all of the terms. Such an estimate can be used as the starting point for further regularization efforts which can improve upon the 1/sqrt{N_sim} limit above, and incorporating such additional steps is straightforward within this framework. We demonstrate the technique with toy models and with an example motivated by large-scale structure two-point analysis, showing significant improvements in the rate of convergence. For the large-scale structure example, we find errors on the precision matrix which are factors of 5 smaller than for the sample precision matrix for thousands of simulations or, alternatively, convergence to the same error level with more than an order of magnitude fewer simulations.

  15. Precision Muonium Spectroscopy

    CERN Document Server

    Jungmann, Klaus P

    2016-01-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 $\\mu$s. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In particular groun dstate hyperfine structure transitions can be measured by microwave spectroscopy to deliver the muon magnetic moment. The frequency of the 1s-2s transition in the hydrogen-like atom can be determined with laser spectroscopy to obtain the muon mass. With such measurements fundamental physical interactions, in particular Quantum Electrodynamics, can also be tested at highest precision. The results are important input parameters for experiments on the muon magnetic anomaly. The simplicity of the atom enables further precise experiments, such as a search for muonium-antimuonium conversion for testing charged lepton number conservation and searches for possible antigravity of muons and dark matter.

  16. Precision Muonium Spectroscopy

    Science.gov (United States)

    Jungmann, Klaus P.

    2016-09-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 µs. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In particular ground state hyperfine structure transitions can be measured by microwave spectroscopy to deliver the muon magnetic moment. The frequency of the 1s-2s transition in the hydrogen-like atom can be determined with laser spectroscopy to obtain the muon mass. With such measurements fundamental physical interactions, in particular quantum electrodynamics, can also be tested at highest precision. The results are important input parameters for experiments on the muon magnetic anomaly. The simplicity of the atom enables further precise experiments, such as a search for muonium-antimuonium conversion for testing charged lepton number conservation and searches for possible antigravity of muons and dark matter.

  17. Precision genome editing

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Bennett, Eric P; Schjoldager, Katrine Ter-Borch Gram

    2014-01-01

    Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not been applied with wide success in the field...... of glycobiology, primarily due to their low efficiencies, with resultant failure to impose substantial phenotypic consequences upon the final glycosylation products. Here, we review novel nuclease-based precision genome editing techniques enabling efficient and stable gene editing, including gene disruption...... by introducing single or double-stranded breaks at a defined genomic sequence. We here compare and contrast the different techniques and summarize their current applications, highlighting cases from the field of glycobiology as well as pointing to future opportunities. The emerging potential of precision gene...

  18. Precision Experiments at LEP

    CERN Document Server

    de Boer, Wim

    2015-01-01

    The Large Electron Positron Collider (LEP) established the Standard Model (SM) of particle physics with unprecedented precision, including all its radiative corrections. These led to predictions for the masses of the top quark and Higgs boson, which were beautifully confirmed later on. After these precision measurements the Nobel Prize in Physics was awarded in 1999 jointly to 't Hooft and Veltman "for elucidating the quantum structure of electroweak interactions in physics". Another hallmark of the LEP results were the precise measurements of the gauge coupling constants, which excluded unification of the forces within the SM, but allowed unification within the supersymmetric extension of the SM. This increased the interest in Supersymmetry (SUSY) and Grand Unified Theories, especially since the SM has no candidate for the elusive dark matter, while Supersymmetry provides an excellent candidate for dark matter. In addition, Supersymmetry removes the quadratic divergencies of the SM and {\\it predicts} the Hig...

  19. Improving Precision of Types

    DEFF Research Database (Denmark)

    Winther, Johnni

    Types in programming languages provide a powerful tool for the programmer to document the code so that a large aspect of the intent can not only be presented to fellow programmers but also be checked automatically by compilers. The precision with which types model the behavior of programs...... is crucial to the quality of these automated checks, and in this thesis we present three different improvements to the precision of types in three different aspects of the Java programming language. First we show how to extend the type system in Java with a new type which enables the detection of unintended...... mixing of unrelated types. Secondly, we present an improvement of the type checking algorithm in Java which enables the compiler to detect and ease the use of a common programming idiom called guarded casts. Thirdly, we present an improvement of the precision with which classes generated by a parser...

  20. Modeling GHG Emissions and Carbon Changes in Agricultural and Forest Systems to Guide Mitigation and Adaptation: Synthesis and Future Needs

    Science.gov (United States)

    Agricultural production systems and land use change for agriculture and forestry are important sources of anthropogenic greenhouse gas (GHG) emissions. Recent commitments by the European Union, the United States, and China to reduce GHG emissions highlight the need to improve estimates of current em...

  1. Guiding Age 10-11 Students to Notice the Salient Features of Physical Change Models in Chemistry Digital Learning Objects

    Science.gov (United States)

    Gustafson, Brenda; Mahaffy, Peter; Martin, Brian

    2015-01-01

    This paper focuses on one Grade 5 class (9 females; 9 males) who worked in student-pairs to view five digital learning object (DLO) lessons created by the authors and meant to introduce students to the nature of models, the particle nature of matter, and physical change. Specifically, the paper focuses on whether DLO design elements could assist…

  2. Precision electron polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Chudakov, Eugene A. [JLAB

    2013-11-01

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. M{\\o}ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at ~300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100\\%-polarized electron target for M{\\o}ller polarimetry.

  3. Precision machine design

    CERN Document Server

    Slocum, Alexander H

    1992-01-01

    This book is a comprehensive engineering exploration of all the aspects of precision machine design - both component and system design considerations for precision machines. It addresses both theoretical analysis and practical implementation providing many real-world design case studies as well as numerous examples of existing components and their characteristics. Fast becoming a classic, this book includes examples of analysis techniques, along with the philosophy of the solution method. It explores the physics of errors in machines and how such knowledge can be used to build an error budget for a machine, how error budgets can be used to design more accurate machines.

  4. Accelerated molecular dynamics and protein conformational change: a theoretical and practical guide using a membrane embedded model neurotransmitter transporter.

    Science.gov (United States)

    Gedeon, Patrick C; Thomas, James R; Madura, Jeffry D

    2015-01-01

    Molecular dynamics simulation provides a powerful and accurate method to model protein conformational change, yet timescale limitations often prevent direct assessment of the kinetic properties of interest. A large number of molecular dynamic steps are necessary for rare events to occur, which allow a system to overcome energy barriers and conformationally transition from one potential energy minimum to another. For many proteins, the energy landscape is further complicated by a multitude of potential energy wells, each separated by high free-energy barriers and each potentially representative of a functionally important protein conformation. To overcome these obstacles, accelerated molecular dynamics utilizes a robust bias potential function to simulate the transition between different potential energy minima. This straightforward approach more efficiently samples conformational space in comparison to classical molecular dynamics simulation, does not require advanced knowledge of the potential energy landscape and converges to the proper canonical distribution. Here, we review the theory behind accelerated molecular dynamics and discuss the approach in the context of modeling protein conformational change. As a practical example, we provide a detailed, step-by-step explanation of how to perform an accelerated molecular dynamics simulation using a model neurotransmitter transporter embedded in a lipid cell membrane. Changes in protein conformation of relevance to the substrate transport cycle are then examined using principle component analysis.

  5. Positioning of Lunar High-Precision Control Points on Chang'E-1/2 Original Images%月面高精度控制点在嫦娥一号和嫦娥二号原始影像上的定位

    Institute of Scientific and Technical Information of China (English)

    夏金超; 任鑫; 刘建军; 牟伶俐; 李春来

    2012-01-01

    Global lunar mapping is one of the four basic objectives of Chang'E program on the first phase. A unified lunar control network is needed for high-precision mapping of the lunar surface. The positioning of high-precision control points on lunar surface images is of crucial importance for the set-up of lunar control network. The authors reviewed the existing lunar control networks, listed the high-precision control points with coordinate and accuracy, and located the most accurate five control points-laser ranging retro reflectors on Chang'E-1 and Chang'E-2 level-02 images. The processing fully utilized the common features between the LRO and Chang'E images, as well as the relative geometry among craters around lunar modules. With the geometric positioning and image correction method, location of these control points on image achieved an accuracy of about one pixel. The positioning of high-precision control points on Chang'E images can provide absolute position reference for the establishment of China's lunar control network.%全月制图是嫦娥一期工程4个基本目标之一.实现高精度月面制图需要建立一个统一的月面控制网,高精度控制点在嫦娥影像上的定位对于月面控制网的建立有着至关重要的意义.分析了现有月面控制网的基本情况及高精度月面控制点位置与精度,确定了落月舱及精度最高的5个棱镜控制点在嫦娥一号和嫦娥二号月球02级原始影像上的位置.定位过程充分利用落月舱在LRO和嫦娥影像上的共同特征,及落月舱局部区域月面环形坑的相对位置关系.通过几何定位与影像纠正的方法确定了控制点的图上位置,达到了约1个像素的定位精度.

  6. Ultra Precision Machining

    Science.gov (United States)

    1990-05-20

    Sieder , Tate], [Baur, Isermann], [Kays, London, 1984]. We have addressed the question of controolling the temperature of oil used in a precision...Stanford, CA, USA. Sidman, M.D., 1986, Adaptive Control of a Flexible Structure, Ph.D. Thesis, Stanford University, Stanford, CA, USA. Sieder , E.N

  7. Teaching with Precision.

    Science.gov (United States)

    Raybould, Ted; Solity, Jonathan

    1982-01-01

    Use of precision teaching principles with learning problem students involves five steps: specifying performance, recording daily behavior, charting daily behavior, recording the teaching approach, and analyzing data. The approach has been successfully implemented through consultation of school psychologists in Walsall, England. (CL)

  8. Precision Muonium Spectroscopy

    NARCIS (Netherlands)

    Jungmann, Klaus P.

    2016-01-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 $\\mu$s. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In p

  9. Role of Imaging in the Era of Precision Medicine.

    Science.gov (United States)

    Giardino, Angela; Gupta, Supriya; Olson, Emmi; Sepulveda, Karla; Lenchik, Leon; Ivanidze, Jana; Rakow-Penner, Rebecca; Patel, Midhir J; Subramaniam, Rathan M; Ganeshan, Dhakshinamoorthy

    2017-01-25

    Precision medicine is an emerging approach for treating medical disorders, which takes into account individual variability in genetic and environmental factors. Preventive or therapeutic interventions can then be directed to those who will benefit most from targeted interventions, thereby maximizing benefits and minimizing costs and complications. Precision medicine is gaining increasing recognition by clinicians, healthcare systems, pharmaceutical companies, patients, and the government. Imaging plays a critical role in precision medicine including screening, early diagnosis, guiding treatment, evaluating response to therapy, and assessing likelihood of disease recurrence. The Association of University Radiologists Radiology Research Alliance Precision Imaging Task Force convened to explore the current and future role of imaging in the era of precision medicine and summarized its finding in this article. We review the increasingly important role of imaging in various oncological and non-oncological disorders. We also highlight the challenges for radiology in the era of precision medicine.

  10. High Precision Measurements Using High Frequency Signals

    CERN Document Server

    Jin, Aohan; Sakurai, Atsunori; Liu, Liang; Edman, Fredrik; Öwall, Viktor; Pullerits, Tonu; Karki, Khadga J

    2014-01-01

    Generalized lock-in amplifiers use digital cavities with Q-factors as high as 5X10^8. In this letter, we show that generalized lock-in amplifiers can be used to analyze microwave (giga-hertz) signals with a precision of few tens of hertz. We propose that the physical changes in the medium of propagation can be measured precisely by the ultra-high precision measurement of the signal. We provide evidence to our proposition by verifying the Newton's law of cooling by measuring the effect of change in temperature on the phase and amplitude of the signals propagating through two calibrated cables. The technique could be used to precisely measure different physical properties of the propagation medium, for example length, resistance, etc. Real time implementation of the technique can open up new methodologies of in-situ virtual metrology in material design.

  11. Guided labworks

    DEFF Research Database (Denmark)

    Jacobsen, Lærke Bang

    For the last 40 years physics education research has shown poor learning outcomes of guided labs. Still this is found to be a very used teaching method in the upper secodary schools. This study explains the teacher's choice of guided labs throught the concept of redesign as obstacle dislodgement...

  12. Precision Constraints on Extra Fermion Generations

    CERN Document Server

    Erler, Jens

    2010-01-01

    In the recent past there has been renewed interest in the possibility of additional fermion generations. At the same time there have been significant changes in the relevant electroweak (EW) precision constraints, in particular in the interpretation of several of the low energy experiments. We summarize the various motivations for the increased activity regarding extra families and analyze them in view of the latest EW precision data.

  13. Precise nuclear physics for the sun

    Energy Technology Data Exchange (ETDEWEB)

    Bemmerer, Daniel

    2012-07-01

    For many centuries, the study of the Sun has been an important testbed for understanding stars that are further away. One of the first astronomical observations Galileo Galilei made in 1612 with the newly invented telescope concerned the sunspots, and in 1814, Joseph von Fraunhofer employed his new spectroscope to discover the absorption lines in the solar spectrum that are now named after him. Even though more refined and new modes of observation are now available than in the days of Galileo and Fraunhofer, the study of the Sun is still high on the agenda of contemporary science, due to three guiding interests. The first is connected to the ages-old human striving to understand the structure of the larger world surrounding us. Modern telescopes, some of them even based outside the Earth's atmosphere in space, have succeeded in observing astronomical objects that are billions of light-years away. However, for practical reasons precision data that are important for understanding stars can still only be gained from the Sun. In a sense, the observations of far-away astronomical objects thus call for a more precise study of the closeby, of the Sun, for their interpretation. The second interest stems from the human desire to understand the essence of the world, in particular the elementary particles of which it consists. Large accelerators have been constructed to produce and collide these particles. However, man-made machines can never be as luminous as the Sun when it comes to producing particles. Solar neutrinos have thus served not only as an astronomical tool to understand the Sun's inner workings, but their behavior on the way from the Sun to the Earth is also being studied with the aim to understand their nature and interactions. The third interest is strictly connected to life on Earth. A multitude of research has shown that even relatively slight changes in the Earth's climate may strongly affect the living conditions in a number of densely

  14. The new approach to the investigation of the roughness changes of the non-uniform materials irradiated with UV light and imaged by means of atomic force microscopy supported with precise repetitive scanning area positioning

    Science.gov (United States)

    Sikora, Andrzej

    2017-03-01

    In this paper, a new approach to the observation of the roughness changes due to the UV light exposition is presented. The advantages of the shown method is based on the utilization of repeatable precise positioning of the sample in order to perform the imaging using atomic force microscopy, which enables continuous observation of the surface’s deterioration at specific areas during every inspection step. As the degradation of the material due to a radiation is a process, the measurements are performed repeatedly after a specific dose of the energy is applied to the surface. In the presented research, three samples: two polyethylene and one polycarbonate, revealing various levels of the homogeneity were used. For each sample seven spots have been chosen and then at each ageing step they are imaged in order to provide reliable information about the roughness changes. It is shown that using this novel approach one can obtain superior degradation detection sensitivity. Additionally, it is possible to verify the impact of the morphological and material non-homogeneities on the investigation results, due to the dispersion of the roughness determination at various areas of a certain sample.

  15. Precision Chemical Abundance Measurements

    DEFF Research Database (Denmark)

    Yong, David; Grundahl, Frank; Meléndez, Jorge;

    2012-01-01

    This talk covers preliminary work in which we apply a strictly differential line-by-line chemical abundance analysis to high quality UVES spectra of the globular cluster NGC 6752. We achieve extremely high precision in the measurement of relative abundance ratios. Our results indicate that the ob......This talk covers preliminary work in which we apply a strictly differential line-by-line chemical abundance analysis to high quality UVES spectra of the globular cluster NGC 6752. We achieve extremely high precision in the measurement of relative abundance ratios. Our results indicate...... that the observed abundance dispersion exceeds the measurement uncertainties and that many pairs of elements show significant correlations when plotting [X1/H] vs. [X2/H]. Our tentative conclusions are that either NGC 6752 is not chemically homogeneous at the ~=0.03 dex level or the abundance variations...

  16. Precision Muon Physics

    CERN Document Server

    Gorringe, T P

    2015-01-01

    The muon is playing a unique role in sub-atomic physics. Studies of muon decay both determine the overall strength and establish the chiral structure of weak interactions, as well as setting extraordinary limits on charged-lepton-flavor-violating processes. Measurements of the muon's anomalous magnetic moment offer singular sensitivity to the completeness of the standard model and the predictions of many speculative theories. Spectroscopy of muonium and muonic atoms gives unmatched determinations of fundamental quantities including the magnetic moment ratio $\\mu_\\mu / \\mu_p$, lepton mass ratio $m_{\\mu} / m_e$, and proton charge radius $r_p$. Also, muon capture experiments are exploring elusive features of weak interactions involving nucleons and nuclei. We will review the experimental landscape of contemporary high-precision and high-sensitivity experiments with muons. One focus is the novel methods and ingenious techniques that achieve such precision and sensitivity in recent, present, and planned experiment...

  17. A passion for precision

    CERN Document Server

    CERN. Geneva

    2006-01-01

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs  as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.Organiser(s): L. Alvarez-Gaume / PH-THNote: * Tea & coffee will be served at 16:00.

  18. Precision laser aiming system

    Science.gov (United States)

    Ahrens, Brandon R.; Todd, Steven N.

    2009-04-28

    A precision laser aiming system comprises a disrupter tool, a reflector, and a laser fixture. The disrupter tool, the reflector and the laser fixture are configurable for iterative alignment and aiming toward an explosive device threat. The invention enables a disrupter to be quickly and accurately set up, aligned, and aimed in order to render safe or to disrupt a target from a standoff position.

  19. Precision disablement aiming system

    Energy Technology Data Exchange (ETDEWEB)

    Monda, Mark J.; Hobart, Clinton G.; Gladwell, Thomas Scott

    2016-02-16

    A disrupter to a target may be precisely aimed by positioning a radiation source to direct radiation towards the target, and a detector is positioned to detect radiation that passes through the target. An aiming device is positioned between the radiation source and the target, wherein a mechanical feature of the aiming device is superimposed on the target in a captured radiographic image. The location of the aiming device in the radiographic image is used to aim a disrupter towards the target.

  20. Time for change: a roadmap to guide the implementation of the World Anti-Doping Code 2015.

    Science.gov (United States)

    Dvorak, Jiri; Baume, Norbert; Botré, Francesco; Broséus, Julian; Budgett, Richard; Frey, Walter O; Geyer, Hans; Harcourt, Peter Rex; Ho, Dave; Howman, David; Isola, Victor; Lundby, Carsten; Marclay, François; Peytavin, Annie; Pipe, Andrew; Pitsiladis, Yannis P; Reichel, Christian; Robinson, Neil; Rodchenkov, Grigory; Saugy, Martial; Sayegh, Souheil; Segura, Jordi; Thevis, Mario; Vernec, Alan; Viret, Marjolaine; Vouillamoz, Marc; Zorzoli, Mario

    2014-05-01

    A medical and scientific multidisciplinary consensus meeting was held from 29 to 30 November 2013 on Anti-Doping in Sport at the Home of FIFA in Zurich, Switzerland, to create a roadmap for the implementation of the 2015 World Anti-Doping Code. The consensus statement and accompanying papers set out the priorities for the antidoping community in research, science and medicine. The participants achieved consensus on a strategy for the implementation of the 2015 World Anti-Doping Code. Key components of this strategy include: (1) sport-specific risk assessment, (2) prevalence measurement, (3) sport-specific test distribution plans, (4) storage and reanalysis, (5) analytical challenges, (6) forensic intelligence, (7) psychological approach to optimise the most deterrent effect, (8) the Athlete Biological Passport (ABP) and confounding factors, (9) data management system (Anti-Doping Administration & Management System (ADAMS), (10) education, (11) research needs and necessary advances, (12) inadvertent doping and (13) management and ethics: biological data. True implementation of the 2015 World Anti-Doping Code will depend largely on the ability to align thinking around these core concepts and strategies. FIFA, jointly with all other engaged International Federations of sports (Ifs), the International Olympic Committee (IOC) and World Anti-Doping Agency (WADA), are ideally placed to lead transformational change with the unwavering support of the wider antidoping community. The outcome of the consensus meeting was the creation of the ad hoc Working Group charged with the responsibility of moving this agenda forward.

  1. The Moral and Ethical Implications of Precision-Guided Munitions

    Science.gov (United States)

    2007-03-01

    state was secured permanently on the world political stage. Grotius was to jurisprudence and the just-war tradition as Francis Bacon and Rene ... Descartes were to philosophy and Galileo Galilei and Sir Isaac Newton were to applied science. Grotius’ interpretation of the just-war tra- dition as it

  2. Soil processes as a guiding principle in precision agriculture

    NARCIS (Netherlands)

    Alphen, van J.

    2002-01-01

    The fact that conventional agricultural practices have many detrimental effects is widely acknowledged (Rabbinge, 1997). To mitigate these effects, Dutch policy makers have implemented environmental laws that are essentially based on characteristic indicators for groundwater quality. This has result

  3. Local collectivities and climatic change. Are you ready? A guide for the adaptation devoted to the local collectivities; Collectivites locales et changement climatique. Etes-vous pret? Un guide pour l'adaptation a l'attention des collectivites locales

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Facing the climatic change effects, it is necessary to develop a national but also regional adaptation policy to the global warming. This guide aims to give, to the local managers, information on the global warming and bring possible adaptation measures. The sectors of planning, buildings, transports, public health, environment and public information are discussed. (A.L.B.)

  4. HBR guides

    CERN Document Server

    Duarte, Nancy; Dillon, Karen

    2015-01-01

    Master your most pressing professional challenges with this seven-volume set that collects the smartest best practices from leading experts all in one place. "HBR Guide to Better Business Writing" and "HBR Guide to Persuasive Presentations" help you perfect your communication skills; "HBR Guide to Managing Up and Across" and "HBR Guide to Office Politics" show you how to build the best professional relationships; "HBR Guide to Finance Basics for Managers" is the one book you'll ever need to teach you about the numbers; "HBR Guide to Project Management" addresses tough questions such as how to manage stakeholder expectations and how to manage uncertainty in a complex project; and "HBR Guide to Getting the Right Work Done" goes beyond basic productivity tips to teach you how to prioritize and focus on your work. This specially priced set of the most popular books in the series makes a perfect gift for aspiring leaders looking for trusted advice. Arm yourself with the advice you need to succeed on the job, from ...

  5. Lasers the power and precision of light

    CERN Document Server

    Diels, Jean-Claude

    2011-01-01

    ""Lasers"" are active ingredients of our modern life, but they are inconspicuous as they often go unnoticed. This intuitive introductory guide will tell you all you want to know about laser technologies in very diverse fields from nuclear and particle physics to medicine, astronomy and ultra-precise metrology. The book is coherently focused on fundamentals, and is aimed to stimulate intuition about present and future applications, while unveiling the halo of myths around lasers. Written by reputable laser experts who think that science should be entertaining, this useful reference relies on si

  6. Closure The Definitive Guide

    CERN Document Server

    Bolin, Michael

    2010-01-01

    If you're ready to use Closure to build rich web applications with JavaScript, this hands-on guide has precisely what you need to learn this suite of tools in depth. Closure makes it easy for experienced JavaScript developers to write and maintain large and complex codebases -- as Google has demonstrated by using Closure with Gmail, Google Docs, and Google Maps. Author and Closure contributor Michael Bolin has included numerous code examples and best practices, as well as valuable information not available publicly until now. You'll learn all about Closure's Library, Compiler, Templates, tes

  7. Motor cortical function and the precision grip.

    Science.gov (United States)

    Geevasinga, Nimeshan; Menon, Parvathi; Kiernan, Matthew C; Vucic, Steve

    2014-12-01

    While task-dependent changes in motor cortical outputs have been previously reported, the issue of whether such changes are specific for complex hand tasks remains unresolved. The aim of the present study was to determine whether cortical inhibitory tone and cortical output were greater during precision grip and power grip. Motor cortex excitability was undertaken by using the transcranial magnetic stimulation threshold tracking technique in 15 healthy subjects. The motor-evoked potential (MEP) responses were recorded over the abductor pollicis brevis (APB), with the hand in the following positions: (1) rest, (2) precision grip and (3) power grip. The MEP amplitude (MEP amplitude REST 23.6 ± 3.3%; MEP amplitude PRECISION GRIP 35.2 ± 5.6%; MEP amplitude POWER GRIP 19.6 ± 3.4%, F = 2.4, P < 0.001) and stimulus-response gradient (SLOPEREST 0.06 ± 0.01; SLOPEPRCISION GRIP 0.15 ± 0.04; SLOPE POWER GRIP 0.07 ± 0.01, P < 0.05) were significantly increased during precision grip. Short interval intracortical inhibition (SICI) was significantly reduced during the precision grip (SICI REST 15.0 ± 2.3%; SICI PRECISION GRIP 9.7 ± 1.5%, SICI POWER GRIP 15.9 ± 2.7%, F = 2.6, P < 0.05). The present study suggests that changes in motor cortex excitability are specific for precision grip, with functional coupling of descending corticospinal pathways controlling thumb and finger movements potentially forming the basis of these cortical changes.

  8. Ultra-precision bearings

    CERN Document Server

    Wardle, F

    2015-01-01

    Ultra-precision bearings can achieve extreme accuracy of rotation, making them ideal for use in numerous applications across a variety of fields, including hard disk drives, roundness measuring machines and optical scanners. Ultraprecision Bearings provides a detailed review of the different types of bearing and their properties, as well as an analysis of the factors that influence motion error, stiffness and damping. Following an introduction to basic principles of motion error, each chapter of the book is then devoted to the basic principles and properties of a specific type of bearin

  9. Precision Electroweak Measurements

    CERN Document Server

    Przysiezniak, H

    2000-01-01

    This talk describes some of the precision electroweak measurements from around the world, namely those related to the Z and W bosons, the top quark mass, sin2 theta_ W at NuTeV, and three other fundamental measurements: alpha-1 m2_ Z, (g-2)_mu at the E821 BNL experiment as well as the atomic parity violation (APV) measurement for the Cesium atom. These and other measurements are set in the context of the Standard Model (SM) and of the electroweak fit predictions. Future prospects for forthcoming experiments are briefly discussed.

  10. Colostomy Guide

    Science.gov (United States)

    ... Side Effects Managing Cancer-related Side Effects Ostomies Colostomy Guide Colostomy surgery is done for many different diseases and problems. Some colostomies are done because of cancer; others are not. ...

  11. Mechanics and Physics of Precise Vacuum Mechanisms

    CERN Document Server

    Deulin, E. A; Panfilov, Yu V; Nevshupa, R. A

    2010-01-01

    In this book the Russian expertise in the field of the design of precise vacuum mechanics is summarized. A wide range of physical applications of mechanism design in electronic, optical-electronic, chemical, and aerospace industries is presented in a comprehensible way. Topics treated include the method of microparticles flow regulation and its determination in vacuum equipment and mechanisms of electronics; precise mechanisms of nanoscale precision based on magnetic and electric rheology; precise harmonic rotary and not-coaxial nut-screw linear motion vacuum feedthroughs with technical parameters considered the best in the world; elastically deformed vacuum motion feedthroughs without friction couples usage; the computer system of vacuum mechanisms failure predicting. This English edition incorporates a number of features which should improve its usefulness as a textbook without changing the basic organization or the general philosophy of presentation of the subject matter of the original Russian work. Exper...

  12. Precision and Accuracy Parameters in Structured Light 3-D Scanning

    DEFF Research Database (Denmark)

    Eiríksson, Eyþór Rúnar; Wilm, Jakob; Pedersen, David Bue

    2016-01-01

    Structured light systems are popular in part because they can be constructed from off-the-shelf low cost components. In this paper we quantitatively show how common design parameters affect precision and accuracy in such systems, supplying a much needed guide for practitioners. Our quantitative m...

  13. Engineering analyses of large precision cathode strip chambers for GEM

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, J.A.; Belser, F.C.; Pratuch, S.M.; Wuest, C.R. [Lawrence Livermore National Lab., CA (United States); Mitselmakher, G. [Superconducting Super Collider Lab., Dallas, TX (United States); Gordeev, A. [Institute of Theoretical and Experimental Physics, Moscow (Russian Federation); Johnson, C.V. [Lawrence Livermore National Lab., CA (United States)]|[Superconducting Super Collider Lab., Dallas, TX (United States); Polychronakos, V.A. [Brookhaven National Lab., Upton, NY (United States); Golutvin, I.A. [Joint Institute for Nuclear Research, Dubna (Russian Federation)

    1993-10-21

    Structural analyses of large precision cathode strip chambers performed up to the date of this publication are documented. Mechanical property data for typical chamber materials are included. This information, originally intended to be an appendix to the {open_quotes}CSC Structural Design Bible,{close_quotes} is presented as a guide for future designers of large chambers.

  14. Precision Medicine in Cancer Treatment

    Science.gov (United States)

    Precision medicine helps doctors select cancer treatments that are most likely to help patients based on a genetic understanding of their disease. Learn about the promise of precision medicine and the role it plays in cancer treatment.

  15. Mathematics for modern precision engineering.

    Science.gov (United States)

    Scott, Paul J; Forbes, Alistair B

    2012-08-28

    The aim of precision engineering is the accurate control of geometry. For this reason, mathematics has a long association with precision engineering: from the calculation and correction of angular scales used in surveying and astronomical instrumentation to statistical averaging techniques used to increase precision. This study illustrates the enabling role the mathematical sciences are playing in precision engineering: modelling physical processes, instruments and complex geometries, statistical characterization of metrology systems and error compensation.

  16. Experimental Precision and Variety Comparison Precision in Regional Crop Trials

    Institute of Scientific and Technical Information of China (English)

    KONG Fan-ling; ZHANG Qun-yuan; GE Zhi-nan; YANG Fu-xin; ZHANG De-gui; LIU Wen-xin

    2002-01-01

    According to the basic concepts of precision and the principles of analysis of variance (ANOVA), precision types for experiments and variety comparison in regional crop trials (RCT) were studied and developed; expected variety comparison precision (EVCP) and realized variety comparison precision (RVCP) and the corresponding statistical indexes of them were proposed. It was explained that experimental precision (EP) and variety comparison precision (VCP) are two kinds of precision of RCT; EP includes error precision and variety mean precision, which can be measured respectively by the coefficient of variation of single observation's error (CVe) and the coefficient of variation of variety mean's error (CVY); VCP includes EVCP and RVCP, which can be measured respectively by the detectable least relative difference (DLRD) and the relative least significant distance (RLSD); EP is an important factor of VCP but not identical to it; RVCP is the realization of EVCP. Besides error, experimental design and GE interaction and ANOVA model affect VCP. Several application examples for these precision indexes were presented, and the precision of regional cotton trials in the Yellow River Valley and the Changjiang Valley were investigated through the historical data of RCTs from 1980 to 1999.

  17. Simple guide to Skype

    CERN Document Server

    Winter, Rick

    2013-01-01

    Simple Guides give you Just the Facts Get up to speed with Skypefast! Simple Guides: get you started quickly. No extra clutter, no extra reading. Learn how to set up Skype, as well as how to add and set up all your friends, family, and other contacts. Find out about all the features of Skype, how to change views, set your status and conduct video and audio only calls. Learn about all the different things you can do to contact your friends and family on Skype for free, and start having fun!

  18. Pneumatic conveying design guide

    CERN Document Server

    Mills, David

    1990-01-01

    Pneumatic Conveying Design Guide is a guide for the design of pneumatic conveying systems and includes detailed data and information on the conveying characteristics of a number of materials with a wide range of properties. This book includes logic diagrams for design procedures and scaling parameters for the conveying line configuration. It also explains how to improve the performance of pneumatic conveyors by optimizing, uprating, and extending the system or adapting it for a change of material. This book consists of 15 chapters divided into three sections and opens with an overview of the s

  19. Windows Vista Administrator's Pocket Guide

    CERN Document Server

    Stanek, William R

    2007-01-01

    Portable and precise, this pocket-sized guide delivers immediate answers for the day-to-day administration of Windows Vista. Zero in on core support and maintenance tasks using quick-reference tables, instructions, and lists. You'll get the precise information you need to solve problems and get the job done-whether you're at your desk or in the field! Get fast facts to: Install and configure Windows Vista-and optimize the user workspaceMaintain operating system components, hardware devices, and driversCreate user and group accounts-and control rights and permissionsAdminister group policy se

  20. On the precision of noise correlation interferometry

    CERN Document Server

    Weaver, Richard L; Larose, Eric; Campillo, Michel

    2011-01-01

    Long duration noisy-looking waveforms such as those obtained in randomly multiply scattering and reverberant media are complex; they resist direct interpretation. Nevertheless, such waveforms are sensitive to small changes in the source of the waves or in the medium in which they propagate. Monitoring such waveforms, whether obtained directly or obtained indirectly by noise correlation, is emerging as a technique for detecting changes in media. Interpretation of changes is in principle problematic; it is not always clear whether a change is due to sources or to the medium. Of particular interest is the detection of small changes in propagation speeds. An expression is derived here for the apparent, but illusory, waveform dilation due to a change of source. The expression permits changes in waveforms due to changes in wavespeed to be distinguished with high precision from changes due to other reasons. The theory is successfully compared with analysis of a laboratory ultrasonic data set and a seismic data set f...

  1. Single mode, extreme precision Doppler spectrographs

    CERN Document Server

    Schwab, Christian; Betters, Christopher H; Bland-Hawthorn, Joss; Mahadevan, Suvrath

    2012-01-01

    The 'holy grail' of exoplanet research today is the detection of an earth-like planet: a rocky planet in the habitable zone around a main-sequence star. Extremely precise Doppler spectroscopy is an indispensable tool to find and characterize earth-like planets; however, to find these planets around solar-type stars, we need nearly one order of magnitude better radial velocity (RV) precision than the best current spectrographs provide. Recent developments in astrophotonics (Bland-Hawthorn & Horton 2006, Bland-Hawthorn et al. 2010) and adaptive optics (AO) enable single mode fiber (SMF) fed, high resolution spectrographs, which can realize the next step in precision. SMF feeds have intrinsic advantages over multimode fiber or slit coupled spectrographs: The intensity distribution at the fiber exit is extremely stable, and as a result the line spread function of a well-designed spectrograph is fully decoupled from input coupling conditions, like guiding or seeing variations (Ihle et al. 2010). Modal noise, a...

  2. Arrival Metering Precision Study

    Science.gov (United States)

    Prevot, Thomas; Mercer, Joey; Homola, Jeffrey; Hunt, Sarah; Gomez, Ashley; Bienert, Nancy; Omar, Faisal; Kraut, Joshua; Brasil, Connie; Wu, Minghong, G.

    2015-01-01

    This paper describes the background, method and results of the Arrival Metering Precision Study (AMPS) conducted in the Airspace Operations Laboratory at NASA Ames Research Center in May 2014. The simulation study measured delivery accuracy, flight efficiency, controller workload, and acceptability of time-based metering operations to a meter fix at the terminal area boundary for different resolution levels of metering delay times displayed to the air traffic controllers and different levels of airspeed information made available to the Time-Based Flow Management (TBFM) system computing the delay. The results show that the resolution of the delay countdown timer (DCT) on the controllers display has a significant impact on the delivery accuracy at the meter fix. Using the 10 seconds rounded and 1 minute rounded DCT resolutions resulted in more accurate delivery than 1 minute truncated and were preferred by the controllers. Using the speeds the controllers entered into the fourth line of the data tag to update the delay computation in TBFM in high and low altitude sectors increased air traffic control efficiency and reduced fuel burn for arriving aircraft during time based metering.

  3. Manufacturing Precise, Lightweight Paraboloidal Mirrors

    Science.gov (United States)

    Hermann, Frederick Thomas

    2006-01-01

    A process for fabricating a precise, diffraction- limited, ultra-lightweight, composite- material (matrix/fiber) paraboloidal telescope mirror has been devised. Unlike the traditional process of fabrication of heavier glass-based mirrors, this process involves a minimum of manual steps and subjective judgment. Instead, this process involves objectively controllable, repeatable steps; hence, this process is better suited for mass production. Other processes that have been investigated for fabrication of precise composite-material lightweight mirrors have resulted in print-through of fiber patterns onto reflecting surfaces, and have not provided adequate structural support for maintenance of stable, diffraction-limited surface figures. In contrast, this process does not result in print-through of the fiber pattern onto the reflecting surface and does provide a lightweight, rigid structure capable of maintaining a diffraction-limited surface figure in the face of changing temperature, humidity, and air pressure. The process consists mainly of the following steps: 1. A precise glass mandrel is fabricated by conventional optical grinding and polishing. 2. The mandrel is coated with a release agent and covered with layers of a carbon- fiber composite material. 3. The outer surface of the outer layer of the carbon-fiber composite material is coated with a surfactant chosen to provide for the proper flow of an epoxy resin to be applied subsequently. 4. The mandrel as thus covered is mounted on a temperature-controlled spin table. 5. The table is heated to a suitable temperature and spun at a suitable speed as the epoxy resin is poured onto the coated carbon-fiber composite material. 6. The surface figure of the optic is monitored and adjusted by use of traditional Ronchi, Focault, and interferometric optical measurement techniques while the speed of rotation and the temperature are adjusted to obtain the desired figure. The proper selection of surfactant, speed or rotation

  4. Alarm management a comprehensive guide

    CERN Document Server

    Hollifield, Bill R

    2011-01-01

    In this second edition, Alarm Management: A Comprehensive Guide, various problems of alarm systems are covered with precise guidance on how they come about and how to effectively correct them. It is written by individuals with vast experience in the different plants, processes, and environments requiring effective alarm management. The second edition is filled with good examples and explanations of procedures, with practical lists and tips on how one should proceed. It is based on hundreds of successful projects.

  5. Ultrasonic precision optical grinding technology

    Science.gov (United States)

    Cahill, Michael J.; Bechtold, Michael J.; Fess, Edward; Wolfs, Frank L.; Bechtold, Rob

    2015-10-01

    As optical geometries become more precise and complex and a wider range of materials are used, the processes used for manufacturing become more critical. As the preparatory stage for polishing, this is especially true for grinding. Slow processing speeds, accelerated tool wear, and poor surface quality are often detriments in manufacturing glass and hard ceramics. The quality of the ground surface greatly influences the polishing process and the resulting finished product. Through extensive research and development, OptiPro Systems has introduced an ultrasonic assisted grinding technology, OptiSonic, which has numerous advantages over traditional grinding processes. OptiSonic utilizes a custom tool holder designed to produce oscillations in line with the rotating spindle. A newly developed software package called IntelliSonic is integral to this platform. IntelliSonic automatically characterizes the tool and continuously optimizes the output frequency for optimal cutting while in contact with the part. This helps maintain a highly consistent process under changing load conditions for a more accurate surface. Utilizing a wide variety of instruments, test have proven to show a reduction in tool wear and increase in surface quality while allowing processing speeds to be increased. OptiSonic has proven to be an enabling technology to overcome the difficulties seen in grinding of glass and hard optical ceramics. OptiSonic has demonstrated numerous advantages over the standard CNC grinding process. Advantages are evident in reduced tool wear, better surface quality, and reduced cycle times due to increased feed rates. These benefits can be seen over numerous applications within the precision optics industry.

  6. Engineering, Trade, and Technical Cluster. Task Analyses. Drafting and Design Technology, Precision Machining Technology, Electronics Technology.

    Science.gov (United States)

    Henrico County Public Schools, Glen Allen, VA. Virginia Vocational Curriculum and Resource Center.

    Developed in Virginia, this publication contains task analysis guides to support selected tech prep programs that prepare students for careers in the engineering, trade, and technical cluster. Three occupations are profiled: drafting and design technology, precision machining technology, and electronics technology. Each guide contains the…

  7. [Precision nutrition in the era of precision medicine].

    Science.gov (United States)

    Chen, P Z; Wang, H

    2016-12-06

    Precision medicine has been increasingly incorporated into clinical practice and is enabling a new era for disease prevention and treatment. As an important constituent of precision medicine, precision nutrition has also been drawing more attention during physical examinations. The main aim of precision nutrition is to provide safe and efficient intervention methods for disease treatment and management, through fully considering the genetics, lifestyle (dietary, exercise and lifestyle choices), metabolic status, gut microbiota and physiological status (nutrient level and disease status) of individuals. Three major components should be considered in precision nutrition, including individual criteria for sufficient nutritional status, biomarker monitoring or techniques for nutrient detection and the applicable therapeutic or intervention methods. It was suggested that, in clinical practice, many inherited and chronic metabolic diseases might be prevented or managed through precision nutritional intervention. For generally healthy populations, because lifestyles, dietary factors, genetic factors and environmental exposures vary among individuals, precision nutrition is warranted to improve their physical activity and reduce disease risks. In summary, research and practice is leading toward precision nutrition becoming an integral constituent of clinical nutrition and disease prevention in the era of precision medicine.

  8. Precise Truss Assembly Using Commodity Parts and Low Precision Welding

    Science.gov (United States)

    Komendera, Erik; Reishus, Dustin; Dorsey, John T.; Doggett, W. R.; Correll, Nikolaus

    2014-01-01

    Hardware and software design and system integration for an intelligent precision jigging robot (IPJR), which allows high precision assembly using commodity parts and low-precision bonding, is described. Preliminary 2D experiments that are motivated by the problem of assembling space telescope optical benches and very large manipulators on orbit using inexpensive, stock hardware and low-precision welding are also described. An IPJR is a robot that acts as the precise "jigging", holding parts of a local structure assembly site in place, while an external low precision assembly agent cuts and welds members. The prototype presented in this paper allows an assembly agent (for this prototype, a human using only low precision tools), to assemble a 2D truss made of wooden dowels to a precision on the order of millimeters over a span on the order of meters. The analysis of the assembly error and the results of building a square structure and a ring structure are discussed. Options for future work, to extend the IPJR paradigm to building in 3D structures at micron precision are also summarized.

  9. Mold design with simulation for chalcogenide glass precision molding

    Science.gov (United States)

    Zhang, Yunlong; Wang, Zhibin; Li, Junqi; Zhang, Feng; Su, Ying; Wang, Zhongqiang

    2016-10-01

    Compare with the manufacturing of the traditional infrared material, such as signal crystal germanium, zinc sulfide, zinc selenide etc, chalcogenide infrared glass is suitable for precision molding for the low soften temperature to have large mass industry production. So the researches of precision glass molding are necessary, especially for the fast development of infrared product. The mold design is one of the key technologies of precision glass molding. In this paper, the mold processing of a sample chalcogenide glass from the technical drawing, mold design, molding to the lens are introduced. From the result of the precision molding, the technology of finite element simulation is a useful way to guiding the mold design. The molded lens by using mold process fit the design requirement.

  10. Cost and Precision of Brownian Clocks

    CERN Document Server

    Barato, Andre C

    2016-01-01

    Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle thus regulating some oscillatory behaviour in a living system. Typically, such a cycle requires free energy often provided by ATP hydrolysis. We investigate the relation between the precision of such a clock and its thermodynamic costs. For clocks driven by a constant thermodynamic force, a given precision requires a minimal cost that diverges as the uncertainty of the clock vanishes. In marked contrast, we show that a clock driven by a periodic variation of an external protocol can achieve arbitrary precision at arbitrarily low cost. This result constitutes a fundamental difference between processes driven by a fixed thermodynamic force and those driven periodically. As a main technical tool, we map a periodically driven system with a deterministic protocol to one subject to an external protocol that changes in stochastic time intervals, which simplifies calculations significantly. In th...

  11. Single Mode, Extreme Precision Doppler Spectrographs

    Science.gov (United States)

    Schwab, Christian; Leon-Saval, Sergio G.; Betters, Christopher H.; Bland-Hawthorn, Joss; Mahadevan, Suvrath

    2014-04-01

    The `holy grail' of exoplanet research today is the detection of an earth-like planet: a rocky planet in the habitable zone around a main-sequence star. Extremely precise Doppler spectroscopy is an indispensable tool to find and characterize earth-like planets; however, to find these planets around solar-type stars, we need nearly one order of magnitude better radial velocity (RV) precision than the best current spectrographs provide. Recent developments in astrophotonics (Bland-Hawthorn & Horton 2006, Bland-Hawthorn et al. 2010) and adaptive optics (AO) enable single mode fiber (SMF) fed, high resolution spectrographs, which can realize the next step in precision. SMF feeds have intrinsic advantages over multimode fiber or slit coupled spectrographs: The intensity distribution at the fiber exit is extremely stable, and as a result the line spread function of a well-designed spectrograph is fully decoupled from input coupling conditions, like guiding or seeing variations (Ihle et al. 2010). Modal noise, a limiting factor in current multimode fiber fed instruments (Baudrand & Walker 2001), can be eliminated by proper design, and the diffraction limited input to the spectrograph allows for very compact instrument designs, which provide excellent optomechanical stability. A SMF is the ideal interface for new, very precise wavelength calibrators, like laser frequency combs (Steinmetz et al. 2008, Osterman et al. 2012), or SMF based Fabry-Perot Etalons (Halverson et al. 2013). At near infrared wavelengths, these technologies are ready to be implemented in on-sky instruments, or already in use. We discuss a novel concept for such a spectrograph.

  12. Changes in the design, fabrication and setting of guide tube support pins in alloy X750; Evolution de la conception, de la fabrication et du montage des broches de fixation des tubes guides de grappes en alliage X750

    Energy Technology Data Exchange (ETDEWEB)

    Benhamou, C.; Chambrin, J.L. [FRAMATOME ANP, 92 - Paris-La-Defence (France); Todeschini, P. [Electricite de France (EDF/RD/MMC), 77 - Moret sur Loing (France); Champredonde, J. [Electricite de France (EDF/SQR/DMT), 91 - Evry (France); Lemaire, E. [Electricite de France (EDF/CAPE), 93 - Saint-Denis (France)

    2004-07-01

    As a consequence of a problem of stress corrosion cracking (SCC) encountered on guide tube support pins (GTSP) of first generation (1982) and of second generation (1987), EDF and Framatome decided in mars 1988 to launch an important program involving a complete overhaul of the design, the material used, the fabrication and the setting in reactor of GTSP. This program has led to the implementation in 900 MWe and 1300 MWe PWR of a new tube guide support pin called NG89. This implementation began in 1989, now 15 years later, 40% of the operating GTSP in 900 MWe and 1300 MWe PWR are of NG89 type, the oldest ones cumulate 105000 hours in service without negative feedback experience. The main features of the NG89 is: - to be made from an alloy X-750 containing boron (from 25 to 45 ppm) - to have a SCC threshold set at 720 MPa - to be machined from metal bars completely treated, - to have a rolling of the fillets, and - to undergo a shot blasting on the zones of the surface the most acted upon. (A.C.)

  13. Woman Precision Parachuting World Champion

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    1. Twenty-four-year-old Sheng Jun won three gold medals at the 22nd World Parachuting Championships. one for women’s group total score title. one for women’s group precision landing title and the other for women’s individual precision landing title. She also created the women’s individual precision landing record of the World Championships by scoring 0.00 ten times.

  14. Precision Adjustable Liquid Regulator (ALR)

    Science.gov (United States)

    Meinhold, R.; Parker, M.

    2004-10-01

    A passive mechanical regulator has been developed for the control of fuel or oxidizer flow to a 450N class bipropellant engine for use on commercial and interplanetary spacecraft. There are several potential benefits to the propulsion system, depending on mission requirements and spacecraft design. This system design enables more precise control of main engine mixture ratio and inlet pressure, and simplifies the pressurization system by transferring the function of main engine flow rate control from the pressurization/propellant tank assemblies, to a single component, the ALR. This design can also reduce the thermal control requirements on the propellant tanks, avoid costly Qualification testing of biprop engines for missions with more stringent requirements, and reduce the overall propulsion system mass and power usage. In order to realize these benefits, the ALR must meet stringent design requirements. The main advantage of this regulator over other units available in the market is that it can regulate about its nominal set point to within +/-0.85%, and change its regulation set point in flight +/-4% about that nominal point. The set point change is handled actively via a stepper motor driven actuator, which converts rotary into linear motion to affect the spring preload acting on the regulator. Once adjusted to a particular set point, the actuator remains in its final position unpowered, and the regulator passively maintains outlet pressure. The very precise outlet regulation pressure is possible due to new technology developed by Moog, Inc. which reduces typical regulator mechanical hysteresis to near zero. The ALR requirements specified an outlet pressure set point range from 225 to 255 psi, and equivalent water flow rates required were in the 0.17 lb/sec range. The regulation output pressure is maintained at +/-2 psi about the set point from a P (delta or differential pressure) of 20 to over 100 psid. Maximum upstream system pressure was specified at 320 psi

  15. The Research on Tool Change Precision of Knife Library and Automatic Tool Changer%基于加权数据融合的刀库及ATC系统可靠性评测研究∗

    Institute of Scientific and Technical Information of China (English)

    张跃明; 黄文杰; 牟宏明; 杨宇

    2015-01-01

    刀库及ATC(自动换刀装置)的可靠性优劣存在多种制约因素,为真实描述其可靠性状态,开发了刀库及ATC可靠性检测系统。系统可以对刀库的换刀精度、换刀时间、油压、油温、电机温度、故障等运行信息进行智能检测和数据采集。综合考虑刀库的功能性和可靠性,并依据使用者和研究者的意见,确定了各制约因素的比重,进而构造系统可靠性评测模型。编写了基于MFC的评测软件,进行数据融合与分析评价,最终给使用者或研究者一个直观的刀库可靠性评分。该方法易于理解,弥补了刀库及ATC可靠性评测的不足。%There are many restricting factors about the reliability of knife library and ATC ( automatic tool changer) , to describe the status of reliability, testing system of knife library and ATC reliability is devel-oped. The system can detect intelligently, and record the data of precision, tool change time, oil pressure, oil temperature, motor temperature, breakdown, etc. comprehensive Considering the functionality and relia-bility of the knife library, and according to the users and the researchers' opinion, the proportion of the vari-ous constraints is determined, and the reliability evaluation model was established. The evaluation software is wrote based on the MFC, data integration, analysis and evaluation is carried out, and a performance score of knife library is gave to the user or the researchers finally . This method is easy to understand and make up for the deficiency of the knife library and the manipulator reliability evaluation.

  16. Centroid precision and orientation precision of planar localization microscopy.

    Science.gov (United States)

    McGray, C; Copeland, C R; Stavis, S M; Geist, J

    2016-09-01

    The concept of localization precision, which is essential to localization microscopy, is formally extended from optical point sources to microscopic rigid bodies. Measurement functions are presented to calculate the planar pose and motion of microscopic rigid bodies from localization microscopy data. Physical lower bounds on the associated uncertainties - termed centroid precision and orientation precision - are derived analytically in terms of the characteristics of the optical measurement system and validated numerically by Monte Carlo simulations. The practical utility of these expressions is demonstrated experimentally by an analysis of the motion of a microelectromechanical goniometer indicated by a sparse constellation of fluorescent nanoparticles. Centroid precision and orientation precision, as developed here, are useful concepts due to the generality of the expressions and the widespread interest in localization microscopy for super-resolution imaging and particle tracking.

  17. Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design.

    Science.gov (United States)

    Farboud, Behnom; Meyer, Barbara J

    2015-04-01

    Success with genome editing by the RNA-programmed nuclease Cas9 has been limited by the inability to predict effective guide RNAs and DNA target sites. Not all guide RNAs have been successful, and even those that were, varied widely in their efficacy. Here we describe and validate a strategy for Caenorhabditis elegans that reliably achieved a high frequency of genome editing for all targets tested in vivo. The key innovation was to design guide RNAs with a GG motif at the 3' end of their target-specific sequences. All guides designed using this simple principle induced a high frequency of targeted mutagenesis via nonhomologous end joining (NHEJ) and a high frequency of precise DNA integration from exogenous DNA templates via homology-directed repair (HDR). Related guide RNAs having the GG motif shifted by only three nucleotides showed severely reduced or no genome editing. We also combined the 3' GG guide improvement with a co-CRISPR/co-conversion approach. For this co-conversion scheme, animals were only screened for genome editing at designated targets if they exhibited a dominant phenotype caused by Cas9-dependent editing of an unrelated target. Combining the two strategies further enhanced the ease of mutant recovery, thereby providing a powerful means to obtain desired genetic changes in an otherwise unaltered genome.

  18. Micro-precise spatiotemporal delivery system embedded in 3D printing for complex tissue regeneration.

    Science.gov (United States)

    Tarafder, Solaiman; Koch, Alia; Jun, Yena; Chou, Conrad; Awadallah, Mary R; Lee, Chang H

    2016-04-25

    Three dimensional (3D) printing has emerged as an efficient tool for tissue engineering and regenerative medicine, given its advantages for constructing custom-designed scaffolds with tunable microstructure/physical properties. Here we developed a micro-precise spatiotemporal delivery system embedded in 3D printed scaffolds. PLGA microspheres (μS) were encapsulated with growth factors (GFs) and then embedded inside PCL microfibers that constitute custom-designed 3D scaffolds. Given the substantial difference in the melting points between PLGA and PCL and their low heat conductivity, μS were able to maintain its original structure while protecting GF's bioactivities. Micro-precise spatial control of multiple GFs was achieved by interchanging dispensing cartridges during a single printing process. Spatially controlled delivery of GFs, with a prolonged release, guided formation of multi-tissue interfaces from bone marrow derived mesenchymal stem/progenitor cells (MSCs). To investigate efficacy of the micro-precise delivery system embedded in 3D printed scaffold, temporomandibular joint (TMJ) disc scaffolds were fabricated with micro-precise spatiotemporal delivery of CTGF and TGFβ3, mimicking native-like multiphase fibrocartilage. In vitro, TMJ disc scaffolds spatially embedded with CTGF/TGFβ3-μS resulted in formation of multiphase fibrocartilaginous tissues from MSCs. In vivo, TMJ disc perforation was performed in rabbits, followed by implantation of CTGF/TGFβ3-μS-embedded scaffolds. After 4 wks, CTGF/TGFβ3-μS embedded scaffolds significantly improved healing of the perforated TMJ disc as compared to the degenerated TMJ disc in the control group with scaffold embedded with empty μS. In addition, CTGF/TGFβ3-μS embedded scaffolds significantly prevented arthritic changes on TMJ condyles. In conclusion, our micro-precise spatiotemporal delivery system embedded in 3D printing may serve as an efficient tool to regenerate complex and inhomogeneous tissues.

  19. Atomic physics precise measurements and ultracold matter

    CERN Document Server

    Inguscio, Massimo

    2013-01-01

    Atomic Physics provides an expert guide to two spectacular new landscapes in physics: precision measurements, which have been revolutionized by the advent of the optical frequency comb, and atomic physics, which has been revolutionized by laser cooling. These advances are not incremental but transformative: they have generated a consilience between atomic and many-body physics, precipitated an explosion of scientific and technological applications, opened new areas of research, and attracted a brilliant generation of younger scientists. The research is advancing so rapidly, the barrage of applications is so dazzling, that students can be bewildered. For both students and experienced scientists, this book provides an invaluable description of basic principles, experimental methods, and scientific applications.

  20. Geometrical precision of 3DP casting form for founding gears

    Directory of Open Access Journals (Sweden)

    T. Markowski

    2010-01-01

    Full Text Available The article presents analysis of geometrical precision of casting form made by means of 3DP method. Three dimentional printing is a universal method of rapid prototyping which can be used to make tools – castings forms as a Rapid Tooling method. By means of this method in direct incremental process a casting form of spur gear was created. Precision of creating the form by 3DP method depends on different factors. Technological factors depending on machine operator include: the thickness of the layer and placing the model in working space. The precision of creating the model also depends on preparing the printer for work: the condition and calibration of printing heads, the condition of the printing unit slide guides and preparing the working space. Three dimentional printer Z510 Spectrum was prepared for work in a way assuring the greatest precision of created models. Technological parameters responsible for precision were set on maximum values. The aim of the research was defining the precision of casting form generated by 3DP Rapid Prototyping Method. The research was made by means of coordinate measuring machine Wenzel LH87. The measuring machine software was used to compare the outcome of the measurement to nominal model 3D-CAD. The problem of tool precision of casting forms generated by Rapid Tooling is rarely considered in literature covering rapid prototyping and casting technologies. That is why the research presented in this article isan original work in the technological and practical aspect.

  1. Note: High precision measurements using high frequency gigahertz signals

    Science.gov (United States)

    Jin, Aohan; Fu, Siyuan; Sakurai, Atsunori; Liu, Liang; Edman, Fredrik; Pullerits, Tõnu; Öwall, Viktor; Karki, Khadga Jung

    2014-12-01

    Generalized lock-in amplifiers use digital cavities with Q-factors as high as 5 × 108 to measure signals with very high precision. In this Note, we show that generalized lock-in amplifiers can be used to analyze microwave (giga-hertz) signals with a precision of few tens of hertz. We propose that the physical changes in the medium of propagation can be measured precisely by the ultra-high precision measurement of the signal. We provide evidence to our proposition by verifying the Newton's law of cooling by measuring the effect of change in temperature on the phase and amplitude of the signals propagating through two calibrated cables. The technique could be used to precisely measure different physical properties of the propagation medium, for example, the change in length, resistance, etc. Real time implementation of the technique can open up new methodologies of in situ virtual metrology in material design.

  2. Precision Teaching: Discoveries and Effects.

    Science.gov (United States)

    Lindsley, Ogden R.

    1992-01-01

    This paper defines precision teaching; describes its monitoring methods by displaying a standard celeration chart and explaining charting conventions; points out precision teaching's roots in laboratory free-operant conditioning; discusses its learning tactics and performance principles; and describes its effectiveness in producing learning gains.…

  3. More Questions on Precision Teaching.

    Science.gov (United States)

    Raybould, E. C.; Solity, J. E.

    1988-01-01

    Precision teaching can accelerate basic skills progress of special needs children. Issues discussed include using probes as performance tests, charting daily progress, using the charted data to modify teaching methods, determining appropriate age levels, assessing the number of students to be precision taught, and carefully allocating time. (JDD)

  4. Precision frequency measurements with interferometric weak values

    CERN Document Server

    Starling, David J; Jordan, Andrew N; Howell, John C; 10.1103/PhysRevA.82.063822

    2011-01-01

    We demonstrate an experiment which utilizes a Sagnac interferometer to measure a change in optical frequency of 129 kHz per root Hz with only 2 mW of continuous wave, single mode input power. We describe the measurement of a weak value and show how even higher frequency sensitivities may be obtained over a bandwidth of several nanometers. This technique has many possible applications, such as precision relative frequency measurements and laser locking without the use of atomic lines.

  5. A computational intelligence approach to the Mars Precision Landing problem

    Science.gov (United States)

    Birge, Brian Kent, III

    Various proposed Mars missions, such as the Mars Sample Return Mission (MRSR) and the Mars Smart Lander (MSL), require precise re-entry terminal position and velocity states. This is to achieve mission objectives including rendezvous with a previous landed mission, or reaching a particular geographic landmark. The current state of the art footprint is in the magnitude of kilometers. For this research a Mars Precision Landing is achieved with a landed footprint of no more than 100 meters, for a set of initial entry conditions representing worst guess dispersions. Obstacles to reducing the landed footprint include trajectory dispersions due to initial atmospheric entry conditions (entry angle, parachute deployment height, etc.), environment (wind, atmospheric density, etc.), parachute deployment dynamics, unavoidable injection error (propagated error from launch on), etc. Weather and atmospheric models have been developed. Three descent scenarios have been examined. First, terminal re-entry is achieved via a ballistic parachute with concurrent thrusting events while on the parachute, followed by a gravity turn. Second, terminal re-entry is achieved via a ballistic parachute followed by gravity turn to hover and then thrust vector to desired location. Third, a guided parafoil approach followed by vectored thrusting to reach terminal velocity is examined. The guided parafoil is determined to be the best architecture. The purpose of this study is to examine the feasibility of using a computational intelligence strategy to facilitate precision planetary re-entry, specifically to take an approach that is somewhat more intuitive and less rigid, and see where it leads. The test problems used for all research are variations on proposed Mars landing mission scenarios developed by NASA. A relatively recent method of evolutionary computation is Particle Swarm Optimization (PSO), which can be considered to be in the same general class as Genetic Algorithms. An improvement over

  6. Precision optical navigation guidance system

    Science.gov (United States)

    Starodubov, D.; McCormick, K.; Nolan, P.; Johnson, D.; Dellosa, M.; Volfson, L.; Fallahpour, A.; Willner, A.

    2016-05-01

    We present the new precision optical navigation guidance system approach that provides continuous, high quality range and bearing data to fixed wing aircraft during landing approach to an aircraft carrier. The system uses infrared optical communications to measure range between ship and aircraft with accuracy and precision better than 1 meter at ranges more than 7.5 km. The innovative receiver design measures bearing from aircraft to ship with accuracy and precision better than 0.5 mRad. The system provides real-time range and bearing updates to multiple aircraft at rates up to several kHz, and duplex data transmission between ship and aircraft.

  7. Modification of guide wire for 22-gauge safe guide.

    Science.gov (United States)

    Suzuki, T; Nishiyama, J; Hasegawa, J; Ito, K; Takiguchi, M; Takahashi, M; Oda, M

    2001-07-01

    accidental puncture of the common carotid artery, which occurred in 1.7% of both groups. No problems with the guide wire were noted in either group. The use of our modified guide wire decreased the incidence of kinking and locking of the guide wire when passing it through the side port. In addition, no guide wire kinking at the puncture site occurred when introducing the dilator. Issues associated with the original J-type guide wire were resolved by 1) changing the guide wire tip to a gentler angle, and 2) fortifying the guide wire by altering its composition.

  8. Accuracy and precision of an IGRT solution.

    Science.gov (United States)

    Webster, Gareth J; Rowbottom, Carl G; Mackay, Ranald I

    2009-01-01

    Image-guided radiotherapy (IGRT) can potentially improve the accuracy of delivery of radiotherapy treatments by providing high-quality images of patient anatomy in the treatment position that can be incorporated into the treatment setup. The achievable accuracy and precision of delivery of highly complex head-and-neck intensity modulated radiotherapy (IMRT) plans with an IGRT technique using an Elekta Synergy linear accelerator and the Pinnacle Treatment Planning System (TPS) was investigated. Four head-and-neck IMRT plans were delivered to a semi-anthropomorphic head-and-neck phantom and the dose distribution was measured simultaneously by up to 20 microMOSFET (metal oxide semiconductor field-effect transmitter) detectors. A volumetric kilovoltage (kV) x-ray image was then acquired in the treatment position, fused with the phantom scan within the TPS using Syntegra software, and used to recalculate the dose with the precise delivery isocenter at the actual position of each detector within the phantom. Three repeat measurements were made over a period of 2 months to reduce the effect of random errors in measurement or delivery. To ensure that the noise remained below 1.5% (1 SD), minimum doses of 85 cGy were delivered to each detector. The average measured dose was systematically 1.4% lower than predicted and was consistent between repeats. Over the 4 delivered plans, 10/76 measurements showed a systematic error > 3% (3/76 > 5%), for which several potential sources of error were investigated. The error was ultimately attributable to measurements made in beam penumbrae, where submillimeter positional errors result in large discrepancies in dose. The implementation of an image-guided technique improves the accuracy of dose verification, particularly within high-dose gradients. The achievable accuracy of complex IMRT dose delivery incorporating image-guidance is within +/- 3% in dose over the range of sample points. For some points in high-dose gradients

  9. Principles of Precision Spectrophotometry: An Advanced Undergraduate Experiment

    Science.gov (United States)

    Billmeyer, Fred W., Jr.

    1974-01-01

    Describes an experiment designed to familiarize students with the operation of a precision spectrophotometer, the effects of changes in operating variables, and the characteristics of such components as sources and detectors. (SLH)

  10. Precision engineering: an evolutionary perspective.

    Science.gov (United States)

    Evans, Chris J

    2012-08-28

    Precision engineering is a relatively new name for a technology with roots going back over a thousand years; those roots span astronomy, metrology, fundamental standards, manufacturing and money-making (literally). Throughout that history, precision engineers have created links across disparate disciplines to generate innovative responses to society's needs and wants. This review combines historical and technological perspectives to illuminate precision engineering's current character and directions. It first provides us a working definition of precision engineering and then reviews the subject's roots. Examples will be given showing the contributions of the technology to society, while simultaneously showing the creative tension between the technological convergence that spurs new directions and the vertical disintegration that optimizes manufacturing economics.

  11. Mobile Robotic Teams Applied to Precision Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    M.D. McKay; M.O. Anderson; N.S. Flann (Utah State University); R.A. Kinoshita; R.W. Gunderson; W.D. Willis (INEEL)

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University�s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in real-time. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  12. Mobile Robotic Teams Applied to Precision Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Matthew Oley; Kinoshita, Robert Arthur; Mckay, Mark D; Willis, Walter David; Gunderson, R.W.; Flann, N.S.

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University’s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in realtime. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  13. 基于CFX的导叶与叶片间距对泵装置性能改变的研究%Study on Guide Vane and Blade Pitch S on Pump Device Performance Change by CFX

    Institute of Scientific and Technical Information of China (English)

    孟庆峰; 陈松山; 何钟宁; 李慈祥

    2013-01-01

    The parallel space S of axial flow pump guide vane inlet side and the outlet side of impeller blade changes on the pump device performance was calculated by numerical simulation method based on CFX. On the mass conservation theorem and momentum conservation theorem , the Navier - Stoke equation and the standard k - ε turbulence model were applicated, Through the three - dimensional turbulent flow numerical simulation on the whole flow passage of axial flow pump, The guide vane outlet velocity field and pressure field were solved. The relationship of the flow, head, power and efficiency were analysised in three cases as S =9mm,S = 12mm,S = 15mm,The parallel space S of axial flow pump guide vane inlet side and the outlet side of impeller blade changes on the pump device performance was studied.%基于CFX采用数值模拟方法计算轴流泵导叶进口边与叶轮叶片出口边的平行间距S的变化对泵装置性能的影响.在质量守恒定理和动量守恒定理的基础上,应用Navier-Stoke方程和标准k-ε湍流模型,通过对轴流泵全流道三维湍流数值模拟,求解了导叶出口处的速度场和压力场.分析了S =9mm,S=12mm,S=15mm3种情况下,流量、扬程、功率和效率的关系,研究了轴流泵导叶进口边与叶轮叶片出口边的平行间距的变化对泵装置性能的影响.

  14. US-guided preoperative hook-wire localization of nonpalpable breast lesions

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Tae Beom; Lee, Sang Kwon; Kim, Hye Jung; Ryeom, Hun Kyu; Kim, Tae Hun; Kim, Yong Ju; Kang, Duk Sik; Lee, Young Ha; Park, Ho Yong [Kyungpook National University College of Medicine, Taegu (Korea, Republic of)

    2000-12-15

    To evaluate the feasibility and efficacy of US-guided preoperative wire localization of nonpalpable breast lesions. US-guided preoperative wire localization was performed upon 45 nonpalpable breast lesions including 14 nonpalpable masses, 11 nonpalpable masses with microcalcifications, 11 ductal lesions, 9 with microcalcifications. No local anesthesia was performed during the localization procedure. Under the US-guidance, the needle with the hook-wire was inserted into the lesion until the hook of the wire reached 1 cm beyond the posterior margin of the lesion. Precise wire positioning was confirmed by mammography. Specimen radiography or specimen ultrasonography was performed in all cases. US-guided preoperative wire localization was successfully achieved in all cases. The time required for US-guided wire localization was less than five minutes. All lesions were successfully removed by surgical excision. Successful removal was confirmed by specimen radiography or specimen ultrasonography, gross findings of the specimen and consistency between radiographic and pathologic findings. The histologic diagnosis of 45 lesions were 7 ductal carcinoma in situ, 8 invasive ductal carcinoma, 6 fibroadenoma, 8 intraductal papilloma, 2 atypical ductal hyperplasia, and 14 fibrocystic changes. No complications were occurred during and after the procedure. US-guided preoperative wire localization for excisional biopsy is simple, safe, and accurate method in the histologic diagnosis of nonpalpable breast lesions detectable with ultrasonography.

  15. Kinematic precision of gear trains

    Science.gov (United States)

    Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

    1982-01-01

    Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory.

  16. Kinematic precision of gear trains

    Science.gov (United States)

    Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

    1983-01-01

    Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory. Previously announced in STAR as N82-32733

  17. The magic road to precision

    CERN Document Server

    Safronova, M S; Safronova, U I; Clark, Charles W

    2015-01-01

    We predict a sequence of magic-zero wavelengths for the Sr excited $5s5p~ ^3P_0$ state, and provide a general roadmap for extracting transition matrix elements using precise frequency measurements. We demonstrate that such measurements can serve as a best global benchmark of the spectroscopic accuracy that is required for the development of high-precision predictive methods. These magic-zero wavelengths are also needed for state-selective atom manipulation for implementation of quantum logic operations. We also identify five magic wavelengths of the $5s^2\\ ^1S_0 - 5s5p\\ ^3P_0$ Sr clock transition between 350 nm and 500 nm which can also serve as precision benchmarks.

  18. Precise Orbit Determination for ALOS

    Science.gov (United States)

    Nakamura, Ryo; Nakamura, Shinichi; Kudo, Nobuo; Katagiri, Seiji

    2007-01-01

    The Advanced Land Observing Satellite (ALOS) has been developed to contribute to the fields of mapping, precise regional land coverage observation, disaster monitoring, and resource surveying. Because the mounted sensors need high geometrical accuracy, precise orbit determination for ALOS is essential for satisfying the mission objectives. So ALOS mounts a GPS receiver and a Laser Reflector (LR) for Satellite Laser Ranging (SLR). This paper deals with the precise orbit determination experiments for ALOS using Global and High Accuracy Trajectory determination System (GUTS) and the evaluation of the orbit determination accuracy by SLR data. The results show that, even though the GPS receiver loses lock of GPS signals more frequently than expected, GPS-based orbit is consistent with SLR-based orbit. And considering the 1 sigma error, orbit determination accuracy of a few decimeters (peak-to-peak) was achieved.

  19. Retrofit Best Practices Guide

    Energy Technology Data Exchange (ETDEWEB)

    Stovall, T.K.

    2004-01-13

    Few people add siding or change their windows just to reduce their energy bills. But whatever your reasons for retrofitting your home, this will be an important opportunity to improve your home's energy efficiency. Not only will this reduce your utility bills, it will also improve your comfort level and improve our environment. Retrofitting your house is a big deal, and you shouldn't underestimate the effort that will be required to plan the job properly. The energy conservation rewards can be great, but there are also pitfalls that you'll want to avoid. That's what this Best Practices Guide is all about. We can't cover all the issues in these few pages, but we'll tell you some things you need to know if you're changing your siding or windows, and tell you where to learn more about other changes you may want to make to your house. What exactly is a ''best practice''? To put this guide together, we've tested products, talked to contractors and manufacturers, and reviewed the results from a large number of house retrofits. Of course, ''best'' will vary according to the situation. That's why you must start with a careful examination of your house and its existing condition.

  20. RTF Pocket Guide

    CERN Document Server

    Burke, Sean

    2008-01-01

    Rich Text Format, or RTF, is the internal markup language used by Microsoft Word and understood by dozens of other word processors. RTF is a universal file format that pervades practically every desktop. Because RTF is text, it's much easier to generate and process than binary .doc files. Any programmer working with word processing documents needs to learn enough RTF to get around, whether it's to format text for Word (or almost any other word processor), to make global changes to an existing document, or to convert Word files to (or from) another format. RTF Pocket Guide is a concise and e

  1. Investigation on the use of artificial neural networks to overcome the effects of environmental and operational changes on guided waves monitoring

    Science.gov (United States)

    El Mountassir, M.; Yaacoubi, S.; Dahmene, F.

    2015-07-01

    Intelligent feature extraction and advanced signal processing techniques are necessary for a better interpretation of ultrasonic guided waves signals either in structural health monitoring (SHM) or in nondestructive testing (NDT). Such signals are characterized by at least multi-modal and dispersive components. In addition, in SHM, these signals are closely vulnerable to environmental and operational conditions (EOCs), and can be severely affected. In this paper we investigate the use of Artificial Neural Network (ANN) to overcome these effects and to provide a reliable damage detection method with a minimal of false indications. An experimental case of study (full scale pipe) is presented. Damages sizes have been increased and their shapes modified in different steps. Various parameters such as the number of inputs and the number of hidden neurons were studied to find the optimal configuration of the neural network.

  2. Precision agriculture and food security.

    Science.gov (United States)

    Gebbers, Robin; Adamchuk, Viacheslav I

    2010-02-12

    Precision agriculture comprises a set of technologies that combines sensors, information systems, enhanced machinery, and informed management to optimize production by accounting for variability and uncertainties within agricultural systems. Adapting production inputs site-specifically within a field and individually for each animal allows better use of resources to maintain the quality of the environment while improving the sustainability of the food supply. Precision agriculture provides a means to monitor the food production chain and manage both the quantity and quality of agricultural produce.

  3. Sensing technologies for precision irrigation

    CERN Document Server

    Ćulibrk, Dubravko; Minic, Vladan; Alonso Fernandez, Marta; Alvarez Osuna, Javier; Crnojevic, Vladimir

    2014-01-01

    This brief provides an overview of state-of-the-art sensing technologies relevant to the problem of precision irrigation, an emerging field within the domain of precision agriculture. Applications of wireless sensor networks, satellite data and geographic information systems in the domain are covered. This brief presents the basic concepts of the technologies and emphasizes the practical aspects that enable the implementation of intelligent irrigation systems. The authors target a broad audience interested in this theme and organize the content in five chapters, each concerned with a specific technology needed to address the problem of optimal crop irrigation. Professionals and researchers will find the text a thorough survey with practical applications.

  4. Introduction to precise numerical methods

    CERN Document Server

    Aberth, Oliver

    2007-01-01

    Precise numerical analysis may be defined as the study of computer methods for solving mathematical problems either exactly or to prescribed accuracy. This book explains how precise numerical analysis is constructed. The book also provides exercises which illustrate points from the text and references for the methods presented. All disc-based content for this title is now available on the Web. · Clearer, simpler descriptions and explanations ofthe various numerical methods· Two new types of numerical problems; accurately solving partial differential equations with the included software and computing line integrals in the complex plane.

  5. Precision protection through indirect correlations

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Yao, E-mail: 616969274@qq.com

    2016-04-15

    The dynamics of the quantum Fisher information of the parameters of the initial atomic state is studied, in the framework of open quantum systems, for a pair of static two-level atoms coupled to a bath of fluctuating vacuum scalar fields. Our results show that the correlations between the two atoms as well as the precision limit in quantum metrology are determined by the separation between the two atoms. Remarkably, when the separation between the two atoms approaches zero, the quantum Fisher information, thus the precision limit of the estimation of the parameters of the initial atomic state will be survived from the vacuum fluctuations after long time evolution.

  6. ELECTROWEAK PHYSICS AND PRECISION STUDIES.

    Energy Technology Data Exchange (ETDEWEB)

    MARCIANO, W.

    2005-10-24

    The utility of precision electroweak measurements for predicting the Standard Model Higgs mass via quantum loop effects is discussed. Current values of m{sub W}, sin{sup 2} {theta}{sub W}(m{sub Z}){sub {ovr MS}} and m{sub t} imply a relatively light Higgs which is below the direct experimental bound but possibly consistent with Supersymmetry expectations. The existence of Supersymmetry is further suggested by a 2{sigma} discrepancy between experiment and theory for the muon anomalous magnetic moment. Constraints from precision studies on other types of ''New Physics'' are also briefly described.

  7. Microbiopsy/precision cutting devices

    Science.gov (United States)

    Krulevitch, Peter A.; Lee, Abraham P.; Northrup, M. Allen; Benett, William J.

    1999-01-01

    Devices for performing tissue biopsy on a small scale (microbiopsy). By reducing the size of the biopsy tool and removing only a small amount of tissue or other material in a minimally invasive manner, the risks, costs, injury and patient discomfort associated with traditional biopsy procedures can be reduced. By using micromachining and precision machining capabilities, it is possible to fabricate small biopsy/cutting devices from silicon. These devices can be used in one of four ways 1) intravascularly, 2) extravascularly, 3) by vessel puncture, and 4) externally. Additionally, the devices may be used in precision surgical cutting.

  8. Magnetic resonance-guided focused ultrasound: a new technology for clinical neurosciences.

    Science.gov (United States)

    Jolesz, Ferenc A; McDannold, Nathan J

    2014-02-01

    Transcranial MRI-guided focused ultrasound (TcMRgFUS) is an old idea but a new technology that may change the entire clinical field of the neurosciences. TcMRgFUS has no cumulative effect, and it is applicable for repeatable treatments, controlled by real-time dosimetry, and capable of immediate tissue destruction. Most importantly, it has extremely accurate targeting and constant monitoring. It is potentially more precise than proton beam therapy and definitely more cost effective. Neuro-oncology may be the most promising area of future TcMRgFUS applications.

  9. Prospects for High-Precision Pulsar Timing

    CERN Document Server

    Liu, K; Kramer, M; Stappers, B W; van Straten, W; Cordes, J M

    2011-01-01

    Timing pulses of pulsars has proved to be a most powerful technique useful to a host of research areas in astronomy and physics. Importantly, the precision of this timing is not only affected by radiometer noise, but also by intrinsic pulse shape changes, interstellar medium (ISM) evolution, instrumental distortions, etc. In this paper we review the known causes of pulse shape variations and assess their effect on the precision and accuracy of a single measurement of pulse arrival time with current instrumentation. Throughout this analysis we use the brightest and most precisely timed millisecond pulsar (MSP), PSR J0437-4715, as a case study, and develop a set of diagnostic tools to evaluate profile stability in timing observations. We conclude that most causes of distortion can be either corrected by state-of-the-art techniques or taken into account in the estimation of time-of-arrival (TOA) uncertainties. The advent of a new generation of radio telescopes (e.g. the Square Kilometre Array, SKA), and their in...

  10. Future challenges for precision QCD

    CERN Document Server

    2016-01-01

    Precision measurements at Run II of the LHC continue to demand smaller theoretical uncertainties. In this meeting we aim to bring together experts in the field to discuss current issues in the theoretical models. Topics of particular interest are Higgs and Top quark physics, new techniques for infrared subtraction and loop integrals as well as fixed order and parton shower matching beyond NLO.

  11. Precision Teaching ... and All That!

    Science.gov (United States)

    Raybould, E. C.; Solity, J. E.

    1988-01-01

    Two proponents of the precision teaching approach to teaching the handicapped discuss such principles as: the problem of partial application of the method; relationship to behaviorism; relationship to experiential learning; and the importance of fluency in task performance, mastery learning, and recordkeeping. (DB)

  12. Precision Cleaning - Path to Premier

    Science.gov (United States)

    Mackler, Scott E.

    2008-01-01

    ITT Space Systems Division s new Precision Cleaning facility provides critical cleaning and packaging of aerospace flight hardware and optical payloads to meet customer performance requirements. The Precision Cleaning Path to Premier Project was a 2007 capital project and is a key element in the approved Premier Resource Management - Integrated Supply Chain Footprint Optimization Project. Formerly precision cleaning was located offsite in a leased building. A new facility equipped with modern precision cleaning equipment including advanced process analytical technology and improved capabilities was designed and built after outsourcing solutions were investigated and found lacking in ability to meet quality specifications and schedule needs. SSD cleans parts that can range in size from a single threaded fastener all the way up to large composite structures. Materials that can be processed include optics, composites, metals and various high performance coatings. We are required to provide verification to our customers that we have met their particulate and molecular cleanliness requirements and we have that analytical capability in this new facility. The new facility footprint is approximately half the size of the former leased operation and provides double the amount of throughput. Process improvements and new cleaning equipment are projected to increase 1st pass yield from 78% to 98% avoiding $300K+/yr in rework costs. Cost avoidance of $350K/yr will result from elimination of rent, IT services, transportation, and decreased utility costs. Savings due to reduced staff expected to net $4-500K/yr.

  13. Precise laser refractometry of liquids

    NARCIS (Netherlands)

    Gonchukov, S.; Vakurov, M.; Yermachenko, V.

    2006-01-01

    The results of development of two versions of the intracavity laser refractometry in reflection (ILRR) are reviewed in this paper. The ILRR method is based on the use of the properties of two-mode lasers with broken cavity and allows the precise refractive investigations of turbid media to be fulfil

  14. Family Day Care Zoning. Local Officials Guide.

    Science.gov (United States)

    Cohen, Abby; And Others

    This guide discusses city planning issues related to family day care zoning. The guide is divided into five sections. The first section discusses child care as a planning issue and focuses on changes in working patterns of families and in residential neighborhoods. The second section describes components of the child care delivery system, which…

  15. AMERICAN STANDARD GUIDE FOR SCHOOL LIGHTING.

    Science.gov (United States)

    Illuminating Engineering Society, New York, NY.

    THIS IS A GUIDE FOR SCHOOL LIGHTING, DESIGNED FOR EDUCATORS AS WELL AS ARCHITECTS. IT MAKES USE OF RECENT RESEARCH, NOTABLY THE BLACKWELL REPORT ON EVALUATION OF VISUAL TASKS. THE GUIDE BEGINS WITH AN OVERVIEW OF CHANGING GOALS AND NEEDS OF SCHOOL LIGHTING, AND A TABULATION OF COMMON CLASSROOM VISUAL TASKS THAT REQUIRE VARIATIONS IN LIGHTING.…

  16. Jacksonville History Curriculum Guide. Grade 3.

    Science.gov (United States)

    Davis, Elisabeth Fern; And Others

    A part of the Social Studies program for third graders in Duval County Public Schools (Jacksonville, Florida) is represented in this curriculum guide. The guide focuses on Jacksonville's history and emphasizes the relationship between people and their environment at various times in history and changes occurring in those relationships. The central…

  17. Precision frequency measurements with interferometric weak values

    Science.gov (United States)

    Starling, David J.; Dixon, P. Ben; Jordan, Andrew N.; Howell, John C.

    2010-12-01

    We demonstrate an experiment which utilizes a Sagnac interferometer to measure a change in optical frequency of 129 ± 7 kHz/Hz with only 2 mW of continuous-wave, single-mode input power. We describe the measurement of a weak value and show how even higher-frequency sensitivities may be obtained over a bandwidth of several nanometers. This technique has many possible applications, such as precision relative frequency measurements and laser locking without the use of atomic lines.

  18. ARPREC: An arbitrary precision computation package

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Yozo, Hida; Li, Xiaoye S.; Thompson, Brandon

    2002-09-01

    This paper describes a new software package for performing arithmetic with an arbitrarily high level of numeric precision. It is based on the earlier MPFUN package, enhanced with special IEEE floating-point numerical techniques and several new functions. This package is written in C++ code for high performance and broad portability and includes both C++ and Fortran-90 translation modules, so that conventional C++ and Fortran-90 programs can utilize the package with only very minor changes. This paper includes a survey of some of the interesting applications of this package and its predecessors.

  19. Using chaos to improve measurement precision

    Institute of Scientific and Technical Information of China (English)

    何斌; 杨灿军; 周银生; 陈鹰

    2002-01-01

    If the measuring signals wore input to the chaotic dynamic system as initial parameters, the system outputs might be in steady state, periodic state or chaos state. If the chaotic dynamic system outputs controlled in the periodic states, the periodic numbers would be changed most with the signals. Our novel method is to add chaotic dynamic vibration to the measurement or sensor system. The sensor sensitivity and precision of a measurement system would be improved with this method. Chaotic dynamics measurement algorithms are given and their sensitivity to parameters are analyzed in this paper. The effects of noises on the system are discussed,

  20. Using chaos to improve measurement precision

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    If the measuring signals were input to the chaotic dynamic system as initial parameters, the system outputs might be in steady state, periodic state or chaos state. If the chaotic dynamic system outputs controlled in the periodic states, the periodic numbers would be changed most with the signals. Our novel method is to add chaotic dynamic vibration to the measurement or sensor system.The sensor sensitivity and precision of a measurement system would be improved with this method. Chaotic dynamics measurement algorithms are given and their sensitivity to parameters are analyzed in this paper. The effects of noises on the system are discussed.

  1. Nanomedicines for image-guided cancer therapy (Conference Presentation)

    Science.gov (United States)

    Zheng, Jinzi

    2016-09-01

    Imaging technologies are being increasingly employed to guide the delivery of cancer therapies with the intent to increase their performance and efficacy. To date, many patients have benefited from image-guided treatments through prolonged survival and improvements in quality of life. Advances in nanomedicine have enabled the development of multifunctional imaging agents that can further increase the performance of image-guided cancer therapy. Specifically, this talk will focus on examples that demonstrate the benefits and application of nanomedicine in the context of image-guide surgery, personalized drug delivery, tracking of cell therapies and high precision radiotherapy delivery.

  2. 76 FR 35024 - Precision Dynamics Corporation San Fernando, CA; Precision Dynamics Corporation, Also Known as...

    Science.gov (United States)

    2011-06-15

    ... Employment and Training Administration Precision Dynamics Corporation San Fernando, CA; Precision Dynamics... for Worker Adjustment Assistance on January 28, 2011, applicable to workers of Precision Dynamics... the subject firm. The Valencia, California location of Precision Dynamics Corporation, also known...

  3. High precision modeling at the 10^{-20} level

    CERN Document Server

    Andres, M; Costea, A; Hackmann, E; Herrmann, S; Lämmerzahl, C; Nesemann, L; Rievers, B; Stephan, E P

    2011-01-01

    The requirements for accurate numerical simulation are increasing constantly. Modern high precision physics experiments now exceed the achievable numerical accuracy of standard commercial and scientific simulation tools. One example are optical resonators for which changes in the optical length are now commonly measured to 10^{-15} precision. The achievable measurement accuracy for resonators and cavities is directly influenced by changes in the distances between the optical components. If deformations in the range of 10^{-15} occur, those effects cannot be modeled and analysed any more with standard methods based on double precision data types. New experimental approaches point out that the achievable experimental accuracies may improve down to the level of 10^{-17} in the near future. For the development and improvement of high precision resonators and the analysis of experimental data, new methods have to be developed which enable the needed level of simulation accuracy. Therefore we plan the development o...

  4. New librarianship field guide

    CERN Document Server

    Lankes, R David

    2016-01-01

    This book offers a guide for librarians who see their profession as a chance to make a positive difference in their communities -- librarians who recognize that it is no longer enough to stand behind a desk waiting to serve. R. David Lankes, author of "The Atlas of New Librarianship," reminds librarians of their mission: to improve society by facilitating knowledge creation in their communities. In this book, he provides tools, arguments, resources, and ideas for fulfilling this mission. Librarians will be prepared to become radical positive change agents in their communities, and other readers will learn to understand libraries in a new way. The librarians of Ferguson, Missouri, famously became positive change agents in August 2014 when they opened library doors when schools were closed because of civil unrest after the shooting of an unarmed teen by police. Working with other local organizations, they provided children and their parents a space for learning, lunch, and peace. But other libraries serve othe...

  5. Cardiac output method comparison studies: the relation of the precision of agreement and the precision of method.

    Science.gov (United States)

    Hapfelmeier, Alexander; Cecconi, Maurizio; Saugel, Bernd

    2016-04-01

    Cardiac output (CO) plays a crucial role in the hemodynamic management of critically ill patients treated in the intensive care unit and in surgical patients undergoing major surgery. In the field of cardiovascular dynamics, innovative techniques for CO determination are increasingly available. Therefore, the number of studies comparing these techniques with a reference, such as pulmonary artery thermodilution, is rapidly growing. There are mainly two outcomes of such method comparison studies: (1) the accuracy of agreement and (2) the precision of agreement. The precision of agreement depends on the precision of each method, i.e., the precision that the studied and the reference technique are able to achieve. We call this "precision of method". A decomposition of variance shows that method agreement does not only depend on the precision of method but also on another important source of variability, i.e., the method's general variability about the true values. Ignorance of that fact leads to falsified conclusions about the precision of method of the studied technique. In CO studies, serial measurements are frequently confused with repeated measurements. But as the actual CO of a subject changes from assessment to assessment, there is no real repetition of a measurement. This situation equals a scenario in which single measurements are given for multiple true values per subject. In such a case it is not possible to assess the precision of method.

  6. NEW PRECISION PIEZOELECTRIC STEP ACTUATOR

    Institute of Scientific and Technical Information of China (English)

    LIU Jianfang; YANG Zhigang; FAN Zunqiang; CHENG Guangming

    2006-01-01

    A new precision piezoelectric actuator is proposed to improve its drive capabilities. The actuator is based on the piezoelectric technology. It adopts the principle of bionics and works with a new method of stator initiative anchoring/loosen and a distortion structure of double-side thin flexible hinge. It solves the problem of anchoring/loosen, frequency, journey, resolution and velocity. The experiment shows that the new linear piezoelectric actuator works with high frequency (100 Hz), high speed (502 μm/s), large travel (>10 mm), high resolution (0.05 μm) and high load (100 N). This kind of new piezoelectric actuator will be applied for large travel and high resolution driving device, optics engineering, precision positioning and some micromanipulation field.

  7. A simple guide to Skype

    CERN Document Server

    Winter, Rick

    2012-01-01

    Readers will hit the ground running with this concise guide to Skype. The book explains basics such as how to set up an account and how to add friends, family, and other contacts. It also discusses some of the program's more advanced features, such as how to change views, set a particular status, and conduct video and audio-only calls. Readers learn how to parlay the benefits of this free service to stay in touch with personal and business contacts with this easy guide.

  8. Numerical precision and data structures

    Science.gov (United States)

    Schenk, W.

    1978-01-01

    Technical proposals and recommendations for revising FORTRAN were studied and categorized. In the area of numerical precision, the proposals basically agree on a set of necessary parameters, although a wide range of nomenclature and specific function names are used. Environmental parameters identified include the following: (1) base of floating point representation, (2) largest positive real number, exponent and integer, (3) largest negative real number, exponent and integer, (4) number of significant digits, and (5) exponent bias.

  9. Precise Quantification of Nanoparticle Internalization

    OpenAIRE

    Gottstein, Claudia; Wu, Guohui; Wong, Benjamin J.; Zasadzinski, Joseph Anthony

    2013-01-01

    Nanoparticles have opened new exciting avenues for both diagnostic and therapeutic applications in human disease, and targeted nanoparticles are increasingly used as specific drug delivery vehicles. The precise quantification of nanoparticle internalization is of importance to measure the impact of physical and chemical properties on the uptake of nanoparticles into target cells or into cells responsible for rapid clearance. Internalization of nanoparticles has been measured...

  10. Precision photometry for planetary transits

    CERN Document Server

    Pont, F; Pont, Frederic; Moutou, Claire

    2007-01-01

    We review the state of the art in follow-up photometry for planetary transit searches. Three topics are discussed: (1) Photometric monitoring of planets discovered by radial velocity to detect possible transits (2) Follow-up photometry of candidates from photometric transit searches to weed out eclipsing binaries and false positives (3) High-precision lightcurves of known transiting planets to increase the accuracy on the planet parameters.

  11. Fit to Electroweak Precision Data

    CERN Document Server

    Erler, J

    2006-01-01

    A brief review of electroweak precision data from LEP, SLC, the Tevatron, and low energies is presented. The global fit to all data including the most recent results on the masses of the top quark and the W boson reinforces the preference for a relatively light Higgs boson. I will also give an outlook on future developments at the Tevatron Run II, CEBAF, the LHC, and the ILC.

  12. Environment-assisted precision measurement

    DEFF Research Database (Denmark)

    Goldstein, G.; Cappellaro, P.; Maze, J. R.

    2011-01-01

    We describe a method to enhance the sensitivity of precision measurements that takes advantage of the environment of a quantum sensor to amplify the response of the sensor to weak external perturbations. An individual qubit is used to sense the dynamics of surrounding ancillary qubits, which are ...... achieves nearly Heisenberg-limited precision measurement, using a novel class of entangled states. We discuss specific applications to improve clock sensitivity using trapped ions and magnetic sensing based on electronic spins in diamond......We describe a method to enhance the sensitivity of precision measurements that takes advantage of the environment of a quantum sensor to amplify the response of the sensor to weak external perturbations. An individual qubit is used to sense the dynamics of surrounding ancillary qubits, which...... are in turn affected by the external field to be measured. The resulting sensitivity enhancement is determined by the number of ancillas that are coupled strongly to the sensor qubit; it does not depend on the exact values of the coupling strengths and is resilient to many forms of decoherence. The method...

  13. Global Social Media Directory: A Resource Guide

    Energy Technology Data Exchange (ETDEWEB)

    Noonan, Christine F.; Piatt, Andrew W.

    2014-10-23

    The Global Social Media Directory is a resource guide providing information on social networking services around the globe. This information changes rapidly, therefore, this document will be updated on a regular basis and as funding permits.

  14. The precision problem in conservation and restoration

    Science.gov (United States)

    Hiers, J. Kevin; Jackson, Stephen T.; Hobbs, Richard J.; Bernhardt, Emily S.; Valentine, Leonie E.

    2016-01-01

    Within the varied contexts of environmental policy, conservation of imperilled species populations, and restoration of damaged habitats, an emphasis on idealized optimal conditions has led to increasingly specific targets for management. Overly-precise conservation targets can reduce habitat variability at multiple scales, with unintended consequences for future ecological resilience. We describe this dilemma in the context of endangered species management, stream restoration, and climate-change adaptation. Inappropriate application of conservation targets can be expensive, with marginal conservation benefit. Reduced habitat variability can limit options for managers trying to balance competing objectives with limited resources. Conservation policies should embrace habitat variability, expand decision-space appropriately, and support adaptation to local circumstances to increase ecological resilience in a rapidly changing world.

  15. Guiding Principles for Building Fit-For-Purpose Land Administration Systems in Developing Countries: Capacity Development, Change Management and Project Delivery

    DEFF Research Database (Denmark)

    McLaren, Robin; Enemark, Stig; Lemmen, Christiaan

    2016-01-01

    Most developing countries are struggling to find remedies for their many land problems that are often causing land conflicts, reducing economic development and preventing countries reaching their true potential. Existing investments in land administration have been built on legacy approaches and ...... and issues associated with implementing FFP land administration, including change management, capacity development and project delivery....... and have not delivered the required pervasive changes and improvements at scale. Solutions have not helped the poor and disadvantaged that have no security of tenure. In fact the beneficiaries have often been the elite and organizations involved in land grabbing. It is time to rethink the approaches. New...

  16. Modulation of alpha power at encoding and retrieval tracks the precision of visual short-term memory.

    Science.gov (United States)

    Poliakov, E; Stokes, M G; Woolrich, M W; Mantini, D; Astle, D E

    2014-12-01

    Our ability to hold information in mind is strictly limited. We sought to understand the relationship between oscillatory brain activity and the allocation of resources within visual short-term memory (VSTM). Participants attempted to remember target arrows embedded among distracters and used a continuous method of responding to report their memory for a cued target item. Trial-to-trial variability in the absolute circular accuracy with which participants could report the target was predicted by event-related alpha synchronization during initial processing of the memoranda and by alpha desynchronization during the retrieval of those items from VSTM. Using a model-based approach, we were also able to explore further which parameters of VSTM-guided behavior were most influenced by alpha band changes. Alpha synchronization during item processing enhanced the precision with which an item could be retained without affecting the likelihood of an item being represented per se (as indexed by the guessing rate). Importantly, our data outline a neural mechanism that mirrors the precision with which items are retained; the greater the alpha power enhancement during encoding, the greater the precision with which that item can be retained.

  17. Rolling out Efavirenz for HIV Precision Medicine in Africa

    DEFF Research Database (Denmark)

    Masimirembwa, Collen; Dandara, Collet; Leutscher, Peter Derek Christian

    2016-01-01

    adverse events (AEs). If EFV use is not monitored, a huge burden of neuropsychiatric AEs and elevated risk of drug resistance due to nonadherence are likely to follow. A monumental EFV-based ART regimen rollout program, through the UNAIDS 90-90-90 and option B plus programs/approaches, is planned, which...... AEs due to EFV therapy, incorporation of pharmacogenetics testing for CYP2B6 to assist in EFV dosing, and measurement of plasma EFV concentration, as a three-pronged rational therapeutic drug monitoring strategy to guide EFV treatment toward precision medicine....

  18. Methods for Precise Submesh Allocation

    Directory of Open Access Journals (Sweden)

    Craig Morgenstern

    1994-01-01

    Full Text Available In this article we describe and compare several recently proposed algorithms for precise submesh allocation in a two-dimensional mesh connected system. The methods surveyed include various frame sliding strategies, the maximum boundary value heuristic, and interval set scan techniques. In addition, a new enhancement to the interval set scan method is described. This enhancement results in an algorithm that has better allocation and run-time performance under a FCFS scheduling policy than any of the other proposed methods. We present results drawn from an extensive simulation study to illustrate the relative efficiency of the various methods.

  19. Improving Precision of Generated ASTs

    DEFF Research Database (Denmark)

    Winther, Johnni

    The parser-generator is an essential tool in grammarware and its output, the parse tree in form of the concrete or abstract syntax tree, often forms the basis for the whole structure of the grammarware application. Several tools for Java encode the parse tree in a class hierarchy generated to mod...... the parsed documents closely within the Java type system. We present two algorithms used in the generation of such classes which improve the precision with which the parsed input is modeled and show that these improvements greatly ease the use of the generated classes....

  20. The Many Faces of Precision

    Directory of Open Access Journals (Sweden)

    Andy eClark

    2013-05-01

    Full Text Available An appreciation of the many roles of ‘precision-weighting’ (upping the gain on select populations of prediction error units opens the door to better accounts of planning and ‘offline simulation’, makes suggestive contact with large bodies of work on embodied and situated cognition, and offers new perspectives on the ‘active brain’. Combined with the complex affordances of language and culture, and operating against the essential backdrop of a variety of more biologically basic ploys and stratagems, the result is a maximally context-sensitive, restless, constantly self-reconfiguring architecture.

  1. Rapid whole genome sequencing and precision neonatology.

    Science.gov (United States)

    Petrikin, Joshua E; Willig, Laurel K; Smith, Laurie D; Kingsmore, Stephen F

    2015-12-01

    Traditionally, genetic testing has been too slow or perceived to be impractical to initial management of the critically ill neonate. Technological advances have led to the ability to sequence and interpret the entire genome of a neonate in as little as 26 h. As the cost and speed of testing decreases, the utility of whole genome sequencing (WGS) of neonates for acute and latent genetic illness increases. Analyzing the entire genome allows for concomitant evaluation of the currently identified 5588 single gene diseases. When applied to a select population of ill infants in a level IV neonatal intensive care unit, WGS yielded a diagnosis of a causative genetic disease in 57% of patients. These diagnoses may lead to clinical management changes ranging from transition to palliative care for uniformly lethal conditions for alteration or initiation of medical or surgical therapy to improve outcomes in others. Thus, institution of 2-day WGS at time of acute presentation opens the possibility of early implementation of precision medicine. This implementation may create opportunities for early interventional, frequently novel or off-label therapies that may alter disease trajectory in infants with what would otherwise be fatal disease. Widespread deployment of rapid WGS and precision medicine will raise ethical issues pertaining to interpretation of variants of unknown significance, discovery of incidental findings related to adult onset conditions and carrier status, and implementation of medical therapies for which little is known in terms of risks and benefits. Despite these challenges, precision neonatology has significant potential both to decrease infant mortality related to genetic diseases with onset in newborns and to facilitate parental decision making regarding transition to palliative care.

  2. Tube Feeding Troubleshooting Guide

    Science.gov (United States)

    Tube Feeding Troubleshoot ing Guide This guide is a tool to assist you, and should not replace your doctor’s ... everyone. table of contents Going Home with Tube Feedings....................................................2 Nausea and ... ...

  3. Electromagnetic ultrasonic guided waves

    CERN Document Server

    Huang, Songling; Li, Weibin; Wang, Qing

    2016-01-01

    This book introduces the fundamental theory of electromagnetic ultrasonic guided waves, together with its applications. It includes the dispersion characteristics and matching theory of guided waves; the mechanism of production and theoretical model of electromagnetic ultrasonic guided waves; the effect mechanism between guided waves and defects; the simulation method for the entire process of electromagnetic ultrasonic guided wave propagation; electromagnetic ultrasonic thickness measurement; pipeline axial guided wave defect detection; and electromagnetic ultrasonic guided wave detection of gas pipeline cracks. This theory and findings on applications draw on the author’s intensive research over the past eight years. The book can be used for nondestructive testing technology and as an engineering reference work. The specific implementation of the electromagnetic ultrasonic guided wave system presented here will also be of value for other nondestructive test developers.

  4. Kid's Guide to Fever

    Science.gov (United States)

    ... in the Operating Room? A Kid's Guide to Fever KidsHealth > For Kids > A Kid's Guide to Fever ... some lighter-weight pajamas. previous continue Fighting a Fever For almost all kids, fevers aren't a ...

  5. 3D-printed guiding templates for improved osteosarcoma resection

    Science.gov (United States)

    Ma, Limin; Zhou, Ye; Zhu, Ye; Lin, Zefeng; Wang, Yingjun; Zhang, Yu; Xia, Hong; Mao, Chuanbin

    2016-03-01

    Osteosarcoma resection is challenging due to the variable location of tumors and their proximity with surrounding tissues. It also carries a high risk of postoperative complications. To overcome the challenge in precise osteosarcoma resection, computer-aided design (CAD) was used to design patient-specific guiding templates for osteosarcoma resection on the basis of the computer tomography (CT) scan and magnetic resonance imaging (MRI) of the osteosarcoma of human patients. Then 3D printing technique was used to fabricate the guiding templates. The guiding templates were used to guide the osteosarcoma surgery, leading to more precise resection of the tumorous bone and the implantation of the bone implants, less blood loss, shorter operation time and reduced radiation exposure during the operation. Follow-up studies show that the patients recovered well to reach a mean Musculoskeletal Tumor Society score of 27.125.

  6. Unprotected Left Main Disease and Percutaneous Intervention: A Prototype for Precision Medicine.

    Science.gov (United States)

    Chatterjee, Arka; Hillegass, William B

    2017-01-01

    The SYNTAX Score based on angiographic findings is an actionable risk prediction model helping guide treatment for significant unprotected left main disease. Adding the clinical factor based EuroSCORE to SYNTAX improves outcome prediction for percutaneous coronary intervention of unprotected left main disease. Prediction models are an increasingly useful tool permitting cardiologists to optimize patient outcomes through "personalized" or precision medicine.

  7. Precision Metrology Using Weak Measurements

    Science.gov (United States)

    Zhang, Lijian; Datta, Animesh; Walmsley, Ian A.

    2015-05-01

    Weak values and measurements have been proposed as a means to achieve dramatic enhancements in metrology based on the greatly increased range of possible measurement outcomes. Unfortunately, the very large values of measurement outcomes occur with highly suppressed probabilities. This raises three vital questions in weak-measurement-based metrology. Namely, (Q1) Does postselection enhance the measurement precision? (Q2) Does weak measurement offer better precision than strong measurement? (Q3) Is it possible to beat the standard quantum limit or to achieve the Heisenberg limit with weak measurement using only classical resources? We analyze these questions for two prototypical, and generic, measurement protocols and show that while the answers to the first two questions are negative for both protocols, the answer to the last is affirmative for measurements with phase-space interactions, and negative for configuration space interactions. Our results, particularly the ability of weak measurements to perform at par with strong measurements in some cases, are instructive for the design of weak-measurement-based protocols for quantum metrology.

  8. Helium 3 neutron precision polarimetry

    Science.gov (United States)

    Menard, Christopher

    2009-10-01

    Measuring neutron polarization to a high degree of precision is critical for the next generation of neutron decay correlation experiments. Polarized neutrons are also used in experiments to probe the hadronic weak interaction which contributes a small portion (˜10-7) of the force between nucleons. Using a beam of cold neutrons at Los Alamos Neutron Science Center (LANSCE), we polarized neutrons and measured their absolute polarization to ˜0.1%. Neutrons were polarized by passing them through a ^3He spin filter, relying on the maximally spin dependent 3He neutron absorption cross section. The neutron polarization can be determined by measuring the wavelength-dependent neutron transmission through the ^3He cell. An independent measurement of the neutron polarization was also obtained by passing the polarized beam through an RF spin flipper and a second polarized ^3He cell, used as an analyzer. To measure the efficiency of the spin flipper, the same measurements were made after reversing the ^3He polarization in the polarizer by using NMR techniques (adiabatic fast passage). We will show the consistency of these two measurements and the resulting precision of neutron polarimetry using these techniques.

  9. Precision metrology using weak measurements.

    Science.gov (United States)

    Zhang, Lijian; Datta, Animesh; Walmsley, Ian A

    2015-05-29

    Weak values and measurements have been proposed as a means to achieve dramatic enhancements in metrology based on the greatly increased range of possible measurement outcomes. Unfortunately, the very large values of measurement outcomes occur with highly suppressed probabilities. This raises three vital questions in weak-measurement-based metrology. Namely, (Q1) Does postselection enhance the measurement precision? (Q2) Does weak measurement offer better precision than strong measurement? (Q3) Is it possible to beat the standard quantum limit or to achieve the Heisenberg limit with weak measurement using only classical resources? We analyze these questions for two prototypical, and generic, measurement protocols and show that while the answers to the first two questions are negative for both protocols, the answer to the last is affirmative for measurements with phase-space interactions, and negative for configuration space interactions. Our results, particularly the ability of weak measurements to perform at par with strong measurements in some cases, are instructive for the design of weak-measurement-based protocols for quantum metrology.

  10. Precision luminosity measurements at LHCb

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Brown, Henry; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Geraci, Angelo; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Moggi, Niccolò; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Pessina, Gianluigi; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilschut, Hans; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-01-01

    Measuring cross-sections at the LHC requires the luminosity to be determined accurately at each centre-of-mass energy $\\sqrt{s}$. In this paper results are reported from the luminosity calibrations carried out at the LHC interaction point 8 with the LHCb detector for $\\sqrt{s}$ = 2.76, 7 and 8 TeV (proton-proton collisions) and for $\\sqrt{s_{NN}}$ = 5 TeV (proton-lead collisions). Both the "van der Meer scan" and "beam-gas imaging" luminosity calibration methods were employed. It is observed that the beam density profile cannot always be described by a function that is factorizable in the two transverse coordinates. The introduction of a two-dimensional description of the beams improves significantly the consistency of the results. For proton-proton interactions at $\\sqrt{s}$ = 8 TeV a relative precision of the luminosity calibration of 1.47% is obtained using van der Meer scans and 1.43% using beam-gas imaging, resulting in a combined precision of 1.12%. Applying the calibration to the full data set determin...

  11. DESIGN OF FARMLAND GIS FOR PRECISION AGRICULTURE

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Precision Agriculture, also known as Precision Farming, or Prescription Farming, is a modern agriculture technology system, which brings " precision" into agriculture system. All concepts of Precision Agriculture are established on the collection and management of variable cropland information. As the tool of collecting, managing and analyzing spatial data, GIS is the key technology of integrated Precision Agriculture system. This article puts forward the concept of Farmland GIS and designs Farmland GIS into five modules, and specifies the functions of the each module, which builds the foundation for practical development of the software. The study and development of Farmland GIS will propel the spreading of Precision Agriculture technology in China.

  12. Evaluating the effectiveness of guided versus non-guided interpretation in the Kruger National Park, South Africa

    Directory of Open Access Journals (Sweden)

    Mark Roberts

    2014-06-01

    Full Text Available In the face of growing pressure placed on the natural environment, the study on which this article is based considered the effectiveness of interpretive provision in mitigating the harmful effects of tourism on the environment. The aim of this research was to determine whether guided or non-guided interpretation is most effective in reaching the stated goals of interpretation. The four key goals of interpretation, namely visitor satisfaction, knowledge gain, attitude change and modification of behaviour intent, were used in the assessment of the relative effectiveness of guided and non-guided interpretation in the Kruger National Park, South Africa. Through comparing responses to questionnaires from post-visit samples and observing both guided and non-guided interpretation, the research found that guided interpretation was only marginally more effective in reaching the four key goals of interpretation than the non-guided interpretive media. Guided interpretation was found to be more effective in terms of visitor satisfaction, whilst guided and non-guided interpretation had only marginal differences in effectiveness in relation to knowledge gain, attitude change and intent to modify behaviour.Conservation implications: The necessity of implementing an appropriate interpretation programme within protected areas cannot be overemphasised. The interpretation programme should be designed to include elements of both guided and non-guided interpretation in order to achieve a predetermined goal. The effectiveness of the programme should be evaluated periodically and amended where appropriate.

  13. Precision and reproducibility in AMS radiocarbon measurements.

    Energy Technology Data Exchange (ETDEWEB)

    Hotchkis, M.A.; Fink, D.; Hua, Q.; Jacobsen, G.E.; Lawson, E. M.; Smith, A.M.; Tuniz, C. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1996-12-31

    Accelerator Mass Spectrometry (AMS) is a technique by which rare radioisotopes such as {sup 14}C can be measured at environmental levels with high efficiency. Instead of detecting radioactivity, which is very weak for long-lived environmental radioisotopes, atoms are counted directly. The sample is placed in an ion source, from which a negative ion beam of the atoms of interest is extracted, mass analysed, and injected into a tandem accelerator. After stripping to positive charge states in the accelerator HV terminal, the ions are further accelerated, analysed with magnetic and electrostatic devices and counted in a detector. An isotopic ratio is derived from the number of radioisotope atoms counted in a given time and the beam current of a stable isotope of the same element, measured after the accelerator. For radiocarbon, {sup 14}C/{sup 13}C ratios are usually measured, and the ratio of an unknown sample is compared to that of a standard. The achievable precision for such ratio measurements is limited primarily by {sup 14}C counting statistics and also by a variety of factors related to accelerator and ion source stability. At the ANTARES AMS facility at Lucas Heights Research Laboratories we are currently able to measure {sup 14}C with 0.5% precision. In the two years since becoming operational, more than 1000 {sup 14}C samples have been measured. Recent improvements in precision for {sup 14}C have been achieved with the commissioning of a 59 sample ion source. The measurement system, from sample changing to data acquisition, is under common computer control. These developments have allowed a new regime of automated multi-sample processing which has impacted both on the system throughput and the measurement precision. We have developed data evaluation methods at ANTARES which cross-check the self-consistency of the statistical analysis of our data. Rigorous data evaluation is invaluable in assessing the true reproducibility of the measurement system and aids in

  14. Ultrasound-Guided Breast Biopsy

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound-Guided Breast Biopsy An ultrasound-guided breast biopsy ... limitations of Ultrasound-Guided Breast Biopsy? What is Ultrasound-Guided Breast Biopsy? Lumps or abnormalities in the ...

  15. Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study

    Directory of Open Access Journals (Sweden)

    Jan Fox

    2016-04-01

    Full Text Available We performed voxel-guided morphometry (VGM investigating the mechanisms of brain atrophy in multiple sclerosis (MS related to focal lesions. VGM maps detect regional brain changes when comparing 2 time points on high resolution T1-weighted (T1w magnetic resonace imaging (MRI. Two T1w MR datasets from 92 relapsing-remitting MS patients obtained 12 months apart were analysed with VGM. New lesions and volume changes of focal MS lesions as well as in the surrounding tissue were identified by visual inspection on colour coded VGM maps. Lesions were dichotomized in active and inactive lesions. Active lesions, defined by either new lesions (NL (volume increase > 5% in VGM, chronic enlarging lesions (CEL (pre-existent T1w lesions with volume increase > 5%, or chronic shrinking lesions (CSL (pre-existent T1w lesions with volume reduction > 5% in VGM, were accompanied by tissue shrinkage in surrounding and/or functionally related regions. Volume loss within the corpus callosum was highly correlated with the number of lesions in its close proximity. Volume loss in the lateral geniculate nucleus was correlated with lesions along the optic radiation. VGM analysis provides strong evidence that all active lesion types (NL, CEL, and CSL contribute to brain volume reduction in the vicinity of lesions and/or in anatomically and functionally related areas of the brain.

  16. Pulsating White Dwarf Stars and Precision Asteroseismology

    CERN Document Server

    Winget, D E

    2008-01-01

    Galactic history is written in the white dwarf stars. Their surface properties hint at interiors composed of matter under extreme conditions. In the forty years since their discovery, pulsating white dwarf stars have moved from side-show curiosities to center stage as important tools for unraveling the deep mysteries of the Universe. Innovative observational techniques and theoretical modeling tools have breathed life into precision asteroseismology. We are just learning to use this powerful tool, confronting theoretical models with observed frequencies and their time rate-of-change. With this tool, we calibrate white dwarf cosmochronology; we explore equations of state; we measure stellar masses, rotation rates, and nuclear reaction rates; we explore the physics of interior crystallization; we study the structure of the progenitors of Type Ia supernovae, and we test models of dark matter. The white dwarf pulsations are at once the heartbeat of galactic history and a window into unexplored and exotic physics.

  17. Pulsating White Dwarf Stars and Precision Asteroseismology

    Science.gov (United States)

    Winget, D. E.; Kepler, S. O.

    2008-09-01

    Galactic history is written in the white dwarf stars. Their surface properties hint at interiors composed of matter under extreme conditions. In the forty years since their discovery, pulsating white dwarf stars have moved from side-show curiosities to center stage as important tools for unraveling the deep mysteries of the Universe. Innovative observational techniques and theoretical modeling tools have breathed life into precision asteroseismology. We are just learning to use this powerful tool, confronting theoretical models with observed frequencies and their time rate-of-change. With this tool, we calibrate white dwarf cosmochronology; we explore equations of state; we measure stellar masses, rotation rates, and nuclear reaction rates; we explore the physics of interior crystallization; we study the structure of the progenitors of Type Ia supernovae, and we test models of dark matter. The white dwarf pulsations are at once the heartbeat of galactic history and a window into unexplored and exotic physics.

  18. Precision Electrospray Thruster Assembly (PETA) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — New low cost, low volume, low power, rugged electrospray thrusters will be ideal as actuators for precision thrusting, if provided with precision high voltage power...

  19. Design, calibration and testing of precise magnetometers

    DEFF Research Database (Denmark)

    Primdahl, Fritz; Merayo, José M.G.; Brauer, Peter;

    2003-01-01

    The requirements for precise global mapping of the Earth's vector magnetic field from a LEO satellite are discussed.......The requirements for precise global mapping of the Earth's vector magnetic field from a LEO satellite are discussed....

  20. Role of telecommunications in precision agriculture

    Science.gov (United States)

    Precision agriculture has been made possible by the confluence of several technologies: geographic positioning systems, geographic information systems, image analysis software, low-cost microcomputer-based variable rate controller/recorders, and precision tractor guidance systems. While these techn...

  1. Inflationary Perturbations and Precision Cosmology

    CERN Document Server

    Habib, S; Heitmann, K; Jungman, G; Habib, Salman; Heinen, Andreas; Heitmann, Katrin; Jungman, Gerard

    2005-01-01

    Inflationary cosmology provides a natural mechanism for the generation of primordial perturbations which seed the formation of observed cosmic structure and lead to specific signals of anisotropy in the cosmic microwave background radiation. In order to test the broad inflationary paradigm as well as particular models against precision observations, it is crucial to be able to make accurate predictions for the power spectrum of both scalar and tensor fluctuations. We present detailed calculations of these quantities utilizing direct numerical approaches as well as error-controlled uniform approximations, comparing with the (uncontrolled) traditional slow-roll approach. A simple extension of the leading-order uniform approximation yields results for the power spectra amplitudes, the spectral indices, and the running of spectral indices, with accuracy of the order of 0.1% - approximately the same level at which the transfer functions are known. Several representative examples are used to demonstrate these resul...

  2. Precision moisture generation and measurement.

    Energy Technology Data Exchange (ETDEWEB)

    Thornberg, Steven Michael; White, Michael I.; Irwin, Adriane Nadine

    2010-03-01

    In many industrial processes, gaseous moisture is undesirable as it can lead to metal corrosion, polymer degradation, and other materials aging processes. However, generating and measuring precise moisture concentrations is challenging due to the need to cover a broad concentration range (parts-per-billion to percent) and the affinity of moisture to a wide range surfaces and materials. This document will discuss the techniques employed by the Mass Spectrometry Laboratory of the Materials Reliability Department at Sandia National Laboratories to generate and measure known gaseous moisture concentrations. This document highlights the use of a chilled mirror and primary standard humidity generator for the characterization of aluminum oxide moisture sensors. The data presented shows an excellent correlation in frost point measured between the two instruments, and thus provides an accurate and reliable platform for characterizing moisture sensors and performing other moisture related experiments.

  3. Precision QCD measurements at HERA

    Directory of Open Access Journals (Sweden)

    Pirumov Hayk

    2014-01-01

    Full Text Available A review of recent experimental results on perturbative QCD from the HERA experiments H1 and ZEUS is presented. All inclusive deep inelastic cross sections measured by the H1 and ZEUS collaborations in neutral and charged current unpolarised ep scattering are combined. They span six orders of magnitude in negative four-momentum-transfer squared, Q2, and in Bjorken x. This data set is used as the sole input to NLO and NNLO QCD analyses to determine new sets of parton distributions, HERAPDF2.0, with small experimental uncertainties and an estimate of model and parametrisation uncertainties. Also shown are new results on inclusive jet, dijet and trijet differential cross sections measured in neutral current deep inelastic scattering. The precision jet data is used to extract the strong coupling αs at NLO with small experimental errors.

  4. Precision cosmology and the landscape

    Energy Technology Data Exchange (ETDEWEB)

    Bousso, Raphael; Bousso, Raphael

    2006-10-01

    After reviewing the cosmological constant problem -- why is Lambda not huge? -- I outline the two basic approaches that had emerged by the late 1980s, and note that each made a clear prediction. Precision cosmological experiments now indicate that the cosmological constant is nonzero. This result strongly favors the environmental approach, in which vacuum energy can vary discretely among widely separated regions in the universe. The need to explain this variation from first principles constitutes an observational constraint on fundamental theory. I review arguments that string theory satisfies this constraint, as it contains a dense discretuum of metastable vacua. The enormous landscape of vacua calls for novel, statistical methods of deriving predictions, and it prompts us to reexamine our description of spacetime on the largest scales. I discuss the effects of cosmological dynamics, and I speculate that weighting vacua by their entropy production may allow for prior-free predictions that do not resort to explicitly anthropic arguments.

  5. GPS Precision Timing at CERN

    CERN Document Server

    Beetham, C G

    1999-01-01

    For the past decade, the Global Positioning System (GPS) has been used to provide precise time, frequency and position co-ordinates world-wide. Recently, equipment has become available specialising in providing extremely accurate timing information, referenced to Universal Time Co-ordinates (UTC). This feature has been used at CERN to provide time of day information for systems that have been installed in the Proton Synchrotron (PS), Super Proton Synchrotron (SPS) and the Large Electron Positron (LEP) machines. The different systems are described as well as the planned developments, particularly with respect to optical transmission and the Inter-Range Instrumentation Group IRIG-B standard, for future use in the Large Hadron Collider (LHC).

  6. The Leadership Assignment: Creating Change.

    Science.gov (United States)

    Calabrese, Raymond L.

    This book provides change-motivated leaders with an understanding of the change process and the tools to drive change. Eight change principles guide change agents in creating and sustaining change: prepare to lead change; knowledge is power; create empowering mental models; overcome resistance to change; lead change; accelerate the change process;…

  7. SharePoint User's Guide

    CERN Document Server

    Corporation, Infusion Development

    2009-01-01

    This straightforward guide shows SharePoint users how to create and use web sites for sharing and collaboration. Learn to use the document and picture libraries for adding and editing content, add discussion boards and surveys, receive alerts when documents and information have been added or changed, and enhance security. Designed to help you find answers quickly, the book shows how to make the most of SharePoint for productivity and collaboration.

  8. Precision Assembly of Systems on Surfaces (PASS)

    Science.gov (United States)

    2015-02-06

    Precision Assembly of Systems on Surfaces ( PASS ) This program was directed at generating functionalized surfaces and assemblies for electronic and...journals: Number of Papers published in non peer-reviewed journals: Final Report: Precision Assembly of Systems on Surfaces ( PASS ) Report Title This...PRECISION ASSEMBLY OF SYSTEMS ON SURFACES ( PASS ) PI: Timothy M. Swager Massachusetts Institute of Technology Final Report: DARPA, Defense

  9. 21 CFR 872.3165 - Precision attachment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Precision attachment. 872.3165 Section 872.3165...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3165 Precision attachment. (a) Identification. A precision attachment or preformed bar is a device made of austenitic alloys or alloys containing 75...

  10. EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide.

    Science.gov (United States)

    Seror, Raphaèle; Bowman, Simon J; Brito-Zeron, Pilar; Theander, Elke; Bootsma, Hendrika; Tzioufas, Athanasios; Gottenberg, Jacques-Eric; Ramos-Casals, Manel; Dörner, Thomas; Ravaud, Philippe; Vitali, Claudio; Mariette, Xavier; Asmussen, Karsten; Jacobsen, Soren; Bartoloni, Elena; Gerli, Roberto; Bijlsma, Johannes Wj; Kruize, Aike A; Bombardieri, Stefano; Bookman, Arthur; Kallenberg, Cees; Meiners, Petra; Brun, Johan G; Jonsson, Roland; Caporali, Roberto; Carsons, Steven; De Vita, Salvatore; Del Papa, Nicoletta; Devauchelle, Valerie; Saraux, Alain; Fauchais, Anne-Laure; Sibilia, Jean; Hachulla, Eric; Illei, Gabor; Isenberg, David; Jones, Adrian; Manoussakis, Menelaos; Mandl, Thomas; Jacobsson, Lennart; Demoulins, Frederic; Montecucco, Carlomaurizio; Ng, Wan-Fai; Nishiyama, Sumusu; Omdal, Roald; Parke, Ann; Praprotnik, Sonja; Tomsic, Matjia; Price, Elizabeth; Scofield, Hal; L Sivils, Kathy; Smolen, Josef; Laqué, Roser Solans; Steinfeld, Serge; Sutcliffe, Nurhan; Sumida, Takayuki; Valesini, Guido; Valim, Valeria; Vivino, Frederick B; Vollenweider, Cristina

    2015-01-01

    The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS. With the growing use of the ESSDAI, some domains appear to be more challenging to rate than others. The ESSDAI is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure, even a primary outcome measure, in current randomised clinical trials. Therefore, ensuring an accurate and reproducible rating of each domain, by providing a more detailed definition of each domain, has emerged as an urgent need. The purpose of the present article is to provide a user guide for the ESSDAI. This guide provides definitions and precisions on the rating of each domain. It also includes some minor improvement of the score to integrate advance in knowledge of disease manifestations. This user guide may help clinicians to use the ESSDAI, and increase the reliability of rating and consequently of the ability to detect true changes over time. This better appraisal of ESSDAI items, along with the recent definition of disease activity levels and minimal clinically important change, will improve the assessment of patients with primary SS and facilitate the demonstration of effectiveness of treatment for patients with primary SS.

  11. CT-guided ozone/steroid therapy for the treatment of degenerative spinal disease - effect of age, gender, disc pathology and multi-segmental changes

    Energy Technology Data Exchange (ETDEWEB)

    Oder, Bernhard; Loewe, Maria; Reisegger, Michael; Thurnher, Siegfried A. [Hospital Brothers of St. John of God, Department of Radiology and Nuclear Medicine, Vienna (Austria); Lang, Wilfried [Hospital Brothers of St. John of God, Department of Neurology, Vienna (Austria); Ilias, Wilfried [Hospital Brothers of St. John of God, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Vienna (Austria)

    2008-09-15

    Oxygen-ozone nucleolysis (ONL) is a new, minimally invasive procedure for the treatment of discogenic low back pain with or without radicular symptoms. The aim of the present study was to determine associations between the morphology of the basic disease, patient-specific factors and the outcome of the treatment. Six hundred and twelve patients not responding to conservative therapy were divided into five groups (disc bulging, disc herniation, postoperative patients, osteochondrosis, others) and subjected to nucleolysis with ozone and to periradicular infiltration with steroids and local anaesthesia. The success of treatment was assessed by means of a visual analog pain scale (VAS) and the Oswestry Disability Index (ODI). A significant reduction in the VAS was registered after 2 and 6 months (from 8.6 to 5.4 and 6.0; p<0.001) in all patient groups; an excellent therapy response (VAS below 3.0) was achieved by about a third of the patients. A significant improvement in ODI was registered in all patients (46 to 31; p<0.001), most pronounced in the herniation group (25.5, p=0.015). Patients below 50 years had significantly better values in the VAS and ODI score 6 months after treatment. Final VAS and ODI scores for patients with a single diseased segment were 4.2 and 28.0, in two affected segments 6.5 and 32 and in three segments 6.7 and 38.5 (p<0.001 and p=0.051). ONL with periradicular steroid therapy might exert a functional and sustained analgesic effect in patients with degenerative changes in the lumbar spine not responding to conservative therapy and was most effective below 50 years with disc herniation in one segment. (orig.)

  12. Dosimetric and volumetric changes in the rectum and bladder in patients receiving CBCT-guided prostate IMRT: analysis based on daily CBCT dose calculation.

    Science.gov (United States)

    Pearson, David; Gill, Sukhdeep K; Campbell, Nina; Reddy, Krishna

    2016-11-08

    Delivered dose can be calculated by transferring the planned treatment beams onto the daily CBCT. Bladder and rectum volumetric doses were calculated and cor-related to the daily bladder and rectum fullness. Patients for this study underwent hypofractionated prostate IMRT to 70 Gy in 28 fractions. Daily CBCT was utilized for image guidance. A clinically acceptable plan was created using a CTV-to-PTV uniform margin of 5 mm. Image fusion was performed to transfer the bladder and rectum contours onto each CBCT. Contours were then edited to match the anatomy of each CBCT. Using the daily treatment isocenter, the planned beams were transferred onto the CBCT and daily and cumulative DVHs calculated. For the results a total of 168 daily CBCTs were evaluated. The bladder was found to be smaller for 74.7% of the 168 daily CBCTs accessed in this study. This reduction in volume correlated to an increase in the cumulative bladder V70 Gy from 9.47% on the planning CT to 10.99% during treatment. V70Gy for the rectum was 7.27% on the planning CT, when all six patients were averaged, and increased to 11.56% on the average of all daily treatment CBCTs. Increases in volumetric rectum dose correlated with increases in rectal volume. For one patient, the rectum and blad-der absolute V70 Gy, averaged over the course of treatment, increased by 295% and 61%, respectively. Larger variations in the daily bladder and rectal volume were observed and these correlated to large deviations from the volumetric dose received by these structures. In summary, bladder and rectum volume changes during treatment have an effect on the cumulative dose received by these organs. It was observed that the volumetric dose received by the bladder decreases as the volume of the bladder increases. The inverse was true for the rectum.

  13. Next generation sequencing in cancer: opportunities and challenges for precision cancer medicine.

    Science.gov (United States)

    Paolillo, Carmela; Londin, Eric; Fortina, Paolo

    2016-01-01

    Over the past decade, testing the genes of patients and their specific cancer types has become standardized practice in medical oncology since somatic mutations, changes in gene expression and epigenetic modifications are all hallmarks of cancer. However, while cancer genetic assessment has been limited to single biomarkers to guide the use of therapies, improvements in nucleic acid sequencing technologies and implementation of different genome analysis tools have enabled clinicians to detect these genomic alterations and identify functional and disease-associated genomic variants. Next-generation sequencing (NGS) technologies have provided clues about therapeutic targets and genomic markers for novel clinical applications when standard therapy has failed. While Sanger sequencing, an accurate and sensitive approach, allows for the identification of potential novel variants, it is however limited by the single amplicon being interrogated. Similarly, quantitative and qualitative profiling of gene expression changes also represents a challenge for the cancer field. Both RT-PCR and microarrays are efficient approaches, but are limited to the genes present on the array or being assayed. This leaves vast swaths of the transcriptome, including non-coding RNAs and other features, unexplored. With the advent of the ability to collect and analyze genomic sequence data in a timely fashion and at an ever-decreasing cost, many of these limitations have been overcome and are being incorporated into cancer research and diagnostics giving patients and clinicians new hope for targeted and personalized treatment. Below we highlight the various applications of next-generation sequencing in precision cancer medicine.

  14. Optimal synthesis of tunable elastic wave-guides

    DEFF Research Database (Denmark)

    Evgrafov, Anton; Rupp, Cory J.; Dunn, Martin L.

    2008-01-01

    Topology optimization, or control in the coefficients of partial differential equations, has been successfully utilized for designing wave-guides with precisely tailored functionalities. For many applications it would be desirable to have the possibility of drastically altering the wave......-guiding properties of a device “on the fly,” in a controllable manner as an influence of some external input. This would enable wave-guides with highly non-linear input–output mappings, such as for example controllable wave switches. In this paper, we propose using finite elastic pre-straining for the purpose...

  15. Precision velocimetry planet hunting with PARAS: current performance and lessons to inform future extreme precision radial velocity instruments

    Science.gov (United States)

    Roy, Arpita; Chakraborty, Abhijit; Mahadevan, Suvrath; Chaturvedi, Priyanka; Prasad, Neelam J. S. S. V.; Shah, Vishal; Pathan, F. M.; Anandarao, B. G.

    2016-08-01

    The PRL Advanced Radial-velocity Abu-sky Search (PARAS) instrument is a fiber-fed stabilized high-resolution cross-dispersed echelle spectrograph, located on the 1.2 m telescope in Mt. Abu India. Designed for exoplanet detection, PARAS is capable of single-shot spectral coverage of 3800 - 9600 Å, and currently achieving radial velocity (RV) precisions approaching 1 m s-1 over several months using simultaneous ThAr calibration. As such, it is one of the few dedicated stabilized fiber-fed spectrographs on small (1-2 m) telescopes that are able to fill an important niche in RV follow-up and stellar characterization. The success of ground-based RV surveys is motivating the push into extreme precisions, with goals of 10 cm s-1 in the optical and <1 m s-1 in the near-infrared (NIR). Lessons from existing instruments like PARAS are invaluable in informing hardware design, providing pipeline prototypes, and guiding scientific surveys. Here we present our current precision estimates of PARAS based on observations of bright RV standard stars, and describe the evolution of the data reduction and RV analysis pipeline as instrument characterization progresses and we gather longer baselines of data. Secondly, we discuss how our experience with PARAS is a critical component in the development of future cutting edge instruments like (1) the Habitable Zone Planet Finder (HPF), a near-infrared spectrograph optimized to look for planets around M dwarfs, scheduled to be commissioned on the Hobby Eberly Telescope in 2017, and (2) the NEID optical spectrograph, designed in response to the NN-EXPLORE call for an extreme precision Doppler spectrometer (EPDS) for the WIYN telescope. In anticipation of instruments like TESS and GAIA, the ground-based RV support system is being reinforced. We emphasize that instruments like PARAS will play an intrinsic role in providing both complementary follow-up and battlefront experience for these next generation of precision velocimeters.

  16. Addressing Climate Change Adaptation in Regional Transportation Plans in California: A Guide and Online Visualization Tool for Planners to Incorporate Risks of Climate Change Impacts in Policy and Decision-Making

    Science.gov (United States)

    Tao, W.; Tucker, K.; DeFlorio, J.

    2012-12-01

    The reality of a changing climate means that transportation and planning agencies need to understand the potential effects of changes in storm activity, sea levels, temperature, and precipitation patterns; and develop strategies to ensure the continuing robustness and resilience of transportation infrastructure and services. This is a relatively new challenge for California's regional planning agencies - adding yet one more consideration to an already complex and multifaceted planning process. In that light, the California Department of Transportation (Caltrans) is developing a strategy framework using a module-based process that planning agencies can undertake to incorporating the risks of climate change impacts into their decision-making and long-range transportation plans. The module-based approach was developed using a best practices survey of existing work nationally, along with a set of structured interviews with metropolitan planning organizations (MPOs) and regional transportation planning agencies (RTPAs) within California. Findings led to the development of a process, as well as a package of foundational geospatial layers (i.e. the Statewide Transportation Asset Geodatabase - STAG), primarily comprising state and Federal transportation assets. These assets are intersected with a set of geospatial layers for the climate stressors of relevance in the state which are placed in the same reference layers as the STAG; thus providing a full set of GIS layers that can be a starting point for MPOs/RTPAs that want to follow the step-by-step module-based approach in its entirety. The fast-paced changes in science and climate change knowledge requires a flexible platform to display continuously evolving information. To this end, the development of the modules are accompanied by a set of geospatial analysis disseminated using an online web portal. In this way, the information can be relayed to MPO/RTPAs in a easy-to-use fashion that can help them follow the modules

  17. GreyGuide Forum and Repository

    OpenAIRE

    Biagioni, Stefania; Farace, Dominic

    2014-01-01

    We present the GreyGuide: an online forum and repository of good practice in the field of grey literature. The launch of the GreyGuide Repository took place in December 2013 at the Fifteenth International Conference on Grey Literature. Since then, the acquisition of both proposed and published good practices are underway. The GreyGuide as an online forum is currently in a developmental stage and is influenced by the changes that have taken place in GreyNet's new infrastructure commencing in J...

  18. FAST User Guide

    Science.gov (United States)

    Walatka, Pamela P.; Clucas, Jean; McCabe, R. Kevin; Plessel, Todd; Potter, R.; Cooper, D. M. (Technical Monitor)

    1994-01-01

    The Flow Analysis Software Toolkit, FAST, is a software environment for visualizing data. FAST is a collection of separate programs (modules) that run simultaneously and allow the user to examine the results of numerical and experimental simulations. The user can load data files, perform calculations on the data, visualize the results of these calculations, construct scenes of 3D graphical objects, and plot, animate and record the scenes. Computational Fluid Dynamics (CFD) visualization is the primary intended use of FAST, but FAST can also assist in the analysis of other types of data. FAST combines the capabilities of such programs as PLOT3D, RIP, SURF, and GAS into one environment with modules that share data. Sharing data between modules eliminates the drudgery of transferring data between programs. All the modules in the FAST environment have a consistent, highly interactive graphical user interface. Most commands are entered by pointing and'clicking. The modular construction of FAST makes it flexible and extensible. The environment can be custom configured and new modules can be developed and added as needed. The following modules have been developed for FAST: VIEWER, FILE IO, CALCULATOR, SURFER, TOPOLOGY, PLOTTER, TITLER, TRACER, ARCGRAPH, GQ, SURFERU, SHOTET, and ISOLEVU. A utility is also included to make the inclusion of user defined modules in the FAST environment easy. The VIEWER module is the central control for the FAST environment. From VIEWER, the user can-change object attributes, interactively position objects in three-dimensional space, define and save scenes, create animations, spawn new FAST modules, add additional view windows, and save and execute command scripts. The FAST User Guide uses text and FAST MAPS (graphical representations of the entire user interface) to guide the user through the use of FAST. Chapters include: Maps, Overview, Tips, Getting Started Tutorial, a separate chapter for each module, file formats, and system

  19. Precision is in their nature

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    There are more than 100 of them in the LHC ring and they have a total of about 400 degrees of freedom. Each one has 4 motors and the newest ones have their own beam-monitoring pickups. Their jaws constrain the relativistic, high-energy particles to a very small transverse area and protect the machine aperture. We are speaking about the LHC collimators, those ultra-precise instruments that leave escaping unstable particles no chance.   The internal structure of a new LHC collimator featuring (see red arrow) one of the beam position monitor's pickups. Designed at CERN but mostly produced by very specialised manufacturers in Europe, the LHC collimators are among the most complex elements of the accelerator. Their job is to control and safely dispose of the halo particles that are produced by unavoidable beam losses from the circulating beam core. “The LHC collimation system has been designed to ensure that beam losses in superconducting magnets remain below quench limits in al...

  20. Precise quantification of nanoparticle internalization.

    Science.gov (United States)

    Gottstein, Claudia; Wu, Guohui; Wong, Benjamin J; Zasadzinski, Joseph Anthony

    2013-06-25

    Nanoparticles have opened new exciting avenues for both diagnostic and therapeutic applications in human disease, and targeted nanoparticles are increasingly used as specific drug delivery vehicles. The precise quantification of nanoparticle internalization is of importance to measure the impact of physical and chemical properties on the uptake of nanoparticles into target cells or into cells responsible for rapid clearance. Internalization of nanoparticles has been measured by various techniques, but comparability of data between different laboratories is impeded by lack of a generally accepted standardized assay. Furthermore, the distinction between associated and internalized particles has been a challenge for many years, although this distinction is critical for most research questions. Previously used methods to verify intracellular location are typically not quantitative and do not lend themselves to high-throughput analysis. Here, we developed a mathematical model which integrates the data from high-throughput flow cytometry measurements with data from quantitative confocal microscopy. The generic method described here will be a useful tool in biomedical nanotechnology studies. The method was then applied to measure the impact of surface coatings of vesosomes on their internalization by cells of the reticuloendothelial system (RES). RES cells are responsible for rapid clearance of nanoparticles, and the resulting fast blood clearance is one of the major challenges in biomedical applications of nanoparticles. Coating of vesosomes with long chain polyethylene glycol showed a trend for lower internalization by RES cells.

  1. Studying antimatter with laser precision

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    The next generation of antihydrogen trapping devices, ALPHA-2, is moving into CERN’s Antiproton Decelerator (AD) hall. This brand-new experiment will allow the ALPHA collaboration to conduct studies of antimatter with greater precision. ALPHA spokesperson Jeffrey Hangst was recently awarded a grant by the Carlsberg Foundation, which will be used to purchase equipment for the new experiment.   A 3-D view of the new magnet (in blue) and cryostat. The red lines show the paths of laser beams. LHC-type current leads for the superconducting magnets are visible on the top-right of the image. The ALPHA collaboration has been working to trap and study antihydrogen since 2006. Using antiprotons provided by CERN’s Antiproton Decelerator (AD), ALPHA was the first experiment to trap antihydrogen and to hold it long enough to study its properties. “The new ALPHA-2 experiment will use integrated lasers to probe the trapped antihydrogen,” explains Jeffrey Hangst, ALP...

  2. The Age of Precision Cosmology

    Science.gov (United States)

    Chuss, David T.

    2012-01-01

    In the past two decades, our understanding of the evolution and fate of the universe has increased dramatically. This "Age of Precision Cosmology" has been ushered in by measurements that have both elucidated the details of the Big Bang cosmology and set the direction for future lines of inquiry. Our universe appears to consist of 5% baryonic matter; 23% of the universe's energy content is dark matter which is responsible for the observed structure in the universe; and 72% of the energy density is so-called "dark energy" that is currently accelerating the expansion of the universe. In addition, our universe has been measured to be geometrically flat to 1 %. These observations and related details of the Big Bang paradigm have hinted that the universe underwent an epoch of accelerated expansion known as Uinflation" early in its history. In this talk, I will review the highlights of modern cosmology, focusing on the contributions made by measurements of the cosmic microwave background, the faint afterglow of the Big Bang. I will also describe new instruments designed to measure the polarization of the cosmic microwave background in order to search for evidence of cosmic inflation.

  3. Business Architecture A Practical Guide

    CERN Document Server

    Whelan, Jonathan

    2012-01-01

    Organizations today exist in an environment of unprecedented change. They do so against a backdrop of a global, competitive marketplace, the fast-paced enablement of technology, amplified regulation and accelerating organizational complexity. Many organizations are addressing change in a sub-optimal way and they are operating without a clear view of where their operational risks lie. It is these dynamics that are leading organizations to recognise and embrace Business Architecture.With these challenges in mind, this book provides a practical guide on how to employ Business Architecture and how

  4. Relativistic Guiding Center Equations

    Energy Technology Data Exchange (ETDEWEB)

    White, R. B. [PPPL; Gobbin, M. [Euratom-ENEA Association

    2014-10-01

    In toroidal fusion devices it is relatively easy that electrons achieve relativistic velocities, so to simulate runaway electrons and other high energy phenomena a nonrelativistic guiding center formalism is not sufficient. Relativistic guiding center equations including flute mode time dependent field perturbations are derived. The same variables as used in a previous nonrelativistic guiding center code are adopted, so that a straightforward modifications of those equations can produce a relativistic version.

  5. Joomla! 3 beginner's guide

    CERN Document Server

    Tiggeler, Eric

    2014-01-01

    An easy to use, step-by-step guide to creating professional, mobile-friendly websites with the free Joomla CMS. The Joomla! 3 Beginner's Guide Second Edition is the ultimate guide for web developers who wish to build upon their skills and knowledge on creating websites. Even if you're new to this subject, you won't have any difficulty understanding the clear and friendly instructions and explanations. No prior knowledge of HTML and CSS is required.

  6. Sensor Characteristics Reference Guide

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-04-01

    The purpose of the guide is to inform building owners and operators of the current status, capabilities, and limitations of sensor technologies. It is hoped that this guide will aid in the design and procurement process and result in successful implementation of building sensor and control systems. DOE will also use this guide to identify research priorities, develop future specifications for potential market adoption, and provide market clarity through unbiased information.

  7. CISSP study guide

    CERN Document Server

    Conrad, Eric; Feldman, Joshua; Riggins, Kevin

    2011-01-01

    "The Eleventh Hour CISSP Study Guide" is keyed to the latest CISSP exam. This book is streamlined to include only core certification information and is presented for ease of last-minute studying. Main objectives of the exam are covered concisely with key concepts highlighted. This is the only guide you need for last-minute studying. This title answers the toughest questions and highlights core topics. This title can be paired with any other study guide so you are completely prepared.

  8. XML Style Guide

    Science.gov (United States)

    2015-07-01

    TELEMETRY GROUP DOCUMENT 125-15 XML STYLE GUIDE DISTRIBUTION A: APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED...OMB control number. 1. REPORT DATE 01 JUL 2015 2. REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE XML Style Guide 5a. CONTRACT...standard was prepared by the Data Multiplex Committee of the Telemetry Group, Range Commanders Council. The XML Style Guide defines rules and guidelines

  9. Precision velocimetry planet hunting with PARAS: Current performance and lessons to inform future extreme precision radial velocity instruments

    CERN Document Server

    Roy, Arpita; Mahadevan, Suvrath; Chaturvedi, Priyanka; Prasad, Neelam J S S V; Shah, Vishal; Pathan, F M; Anandarao, B G

    2016-01-01

    PARAS is a fiber-fed stabilized high-resolution cross-dispersed echelle spectrograph, located on the 1.2 m telescope in Mt. Abu India. Designed for exoplanet detection, PARAS is capable of single-shot spectral coverage of 3800 - 9600 A, and currently achieving radial velocity (RV) precisions approaching ~1 m/s over several months using simultaneous ThAr calibration. As such, it is one of the few dedicated stabilized fiber-fed spectrographs on small (1-2 m) telescopes that are able to fill an important niche in RV follow-up and stellar characterization. The success of ground-based RV surveys is motivating the push into extreme precisions, with goals of ~10 cm/s in the optical and <1 m/s in the near-infrared (NIR). Lessons from existing instruments like PARAS are invaluable in informing hardware design, providing pipeline prototypes, and guiding scientific surveys. Here we present our current precision estimates of PARAS based on observations of bright RV standard stars, and describe the evolution of the dat...

  10. Linear Atom Guides: Guiding Rydberg Atoms and Progress Toward an Atom Laser

    Science.gov (United States)

    Traxler, Mallory A.

    are also studied. Design and construction of a new linear magnetic atom guide is detailed. This guide beta has many improvements over the original guide alpha: a Zeeman slower, magnetic injection, a physical shutter, and surface adsorption evaporative cooling are some of the main changes. Testing of this new system is underway. It is hoped that the improvements to guide beta will yield an atom density sufficient to reach degeneracy, thereby forming a continuous BEC at the end of the guide. The BEC, which will be continuously replenished by the atoms within the guide, will be outcoupled to form a continuous atom laser.

  11. Workplace Ergonomics Reference Guide

    Science.gov (United States)

    Workplace Ergonomics Reference Guide 2 nd Edition A Publication of the Computer/Electronic Accommodations Program Real Solutions for Real ... Table of Contents.................................................................................................................................. ... Checklist ........................................................................................................................... 3 Ergonomic ...

  12. Precision laser automatic tracking system.

    Science.gov (United States)

    Lucy, R F; Peters, C J; McGann, E J; Lang, K T

    1966-04-01

    A precision laser tracker has been constructed and tested that is capable of tracking a low-acceleration target to an accuracy of about 25 microrad root mean square. In tracking high-acceleration targets, the error is directly proportional to the angular acceleration. For an angular acceleration of 0.6 rad/sec(2), the measured tracking error was about 0.1 mrad. The basic components in this tracker, similar in configuration to a heliostat, are a laser and an image dissector, which are mounted on a stationary frame, and a servocontrolled tracking mirror. The daytime sensitivity of this system is approximately 3 x 10(-10) W/m(2); the ultimate nighttime sensitivity is approximately 3 x 10(-14) W/m(2). Experimental tests were performed to evaluate both dynamic characteristics of this system and the system sensitivity. Dynamic performance of the system was obtained, using a small rocket covered with retroreflective material launched at an acceleration of about 13 g at a point 204 m from the tracker. The daytime sensitivity of the system was checked, using an efficient retroreflector mounted on a light aircraft. This aircraft was tracked out to a maximum range of 15 km, which checked the daytime sensitivity of the system measured by other means. The system also has been used to track passively stars and the Echo I satellite. Also, the system tracked passively a +7.5 magnitude star, and the signal-to-noise ratio in this experiment indicates that it should be possible to track a + 12.5 magnitude star.

  13. Image-guided neurosurgery--state of the art and outlook.

    Science.gov (United States)

    Samii, M; Brinker, T; Samii, A

    1999-09-03

    The surgical possibilities of image guided neurosurgery are presented and critically reviewed. Image guided neurosurgery may enable neurosurgeons to work more precisely than before, and thus reduce mortality and morbidity. However, before the technology achieves widespread acceptance, technical standards must be developed, the intraoperative localisation technology improved, and clinical indications and the cost/benefit ratio clarified. Nevertheless, image guided neurosurgery appears to herald an exciting future in which virtual reality and robotic surgery will emerge as modern techniques.

  14. Motion and gravity effects in the precision of quantum clocks

    CERN Document Server

    Lindkvist, Joel; Johansson, Göran; Fuentes, Ivette

    2014-01-01

    We show that motion and gravity affect the precision of quantum clocks. We consider a localised quantum field as a fundamental model of a quantum clock moving in spacetime and show that its state is modified due to changes in acceleration. By computing the quantum Fisher information we determine how relativistic motion modifies the ultimate bound in the precision of the measurement of time. While in the absence of motion the squeezed vacuum is the ideal state for time estimation, we find that it is highly sensitive to the motion-induced degradation of the quantum Fisher information. We show that coherent states are generally more resilient to this degradation and that in the case of very low initial number of photons, the optimal precision can be even increased by motion. These results can be tested with current technology by using superconducting resonators with tunable boundary conditions.

  15. What Should Guide Reality Construction?

    DEFF Research Database (Denmark)

    Ravn, Ib

    1991-01-01

    The constructivist movement in the social sciences (Berger & Luckmann, Gergen) argues that social institutions are the constructions of a community of human agents. This implies that people possess the power to radically change those institutions. This raises what may be called the values problem...... in constructivism, which, in its simplest form, is put in the title of the present chapter: What should guide reality construction? What principles or values should guide our construction of economic institutions, foreign policies, roles for the sexes, schooling, care for the sick? This values problem......-constructing the reality of her hosts. This acknowledgement implies responsibility and, hence, a personal set of values. If the values problem is central in constructivism as a general outlook on the world, it is even more so in the practice of constructivist research, since the values aspect has been actively suppressed...

  16. Designing for Change: Guide to Adaptive Buildings

    NARCIS (Netherlands)

    De Ridder, E.

    2012-01-01

    This "designers' manual" is made during the TIDO-course AR0531 Smart & Bioclimatic Design. The reinterpretation of the word 'building' as primarily a verb, and by so a continuous process, can lead to new dynamic designs, not having the problem of waste or demolition. This manual aims to emphasize t

  17. Abbreviated guide pneumatic conveying design guide

    CERN Document Server

    Mills, David

    1990-01-01

    Abbreviated Guide: Pneumatic Conveying Design Guide describes the selection, design, and specification of conventional pneumatic conveying systems. The design procedure uses previous test data on the materials to be conveyed. The book also discusses system economics, operating costs, the choice of appropriate components or systems, system control, and system flexibility. The design system involves the type of conveying system for installation, the pipeline parameters, and also the plant components. System selection covers the properties of the material to be conveyed, plant layout, material pr

  18. Study on noise of precision panel saw

    Institute of Scientific and Technical Information of China (English)

    HUWan-yi; QIYing-jie; ZHANGZhao-hao; QIXiao-jie

    2003-01-01

    According to ZBJ65015-89 standard about noise level testing method of woodworking toot, the noise testing for MJg0# and MJCl125 precision panel saws was conducted by using model ND2 precision soundqevel apparatus and double frequency wave filter. The testing results showed that the unloaded running noise source of precision panel saw was mainly from main saw blade and its aeromechanic noise was the largest. The rotating speed was determined as an important factor to impact dynamic characters of precision panel saw as the unloaded running noise increased along with speed increasing. For reducing noise of precision panel saw, the first important way is to reduce the aeromechanic noise produced by main saw blade rotating at high speed; based on assuring the processing precision, choosing tow speed is a better way to drop dawn noise; from the view of design, the diameter of clamping lid is better of half of outer diameter of main saw blade.

  19. [Progress in precision medicine: a scientific perspective].

    Science.gov (United States)

    Wang, B; Li, L M

    2017-01-10

    Precision medicine is a new strategy for disease prevention and treatment by taking into account differences in genetics, environment and lifestyles among individuals and making precise diseases classification and diagnosis, which can provide patients with personalized, targeted prevention and treatment. Large-scale population cohort studies are fundamental for precision medicine research, and could produce best evidence for precision medicine practices. Current criticisms on precision medicine mainly focus on the very small proportion of benefited patients, the neglect of social determinants for health, and the possible waste of limited medical resources. In spite of this, precision medicine is still a most hopeful research area, and would become a health care practice model in the future.

  20. Modeling and control of precision actuators

    CERN Document Server

    Kiong, Tan Kok

    2013-01-01

    IntroductionGrowing Interest in Precise ActuatorsTypes of Precise ActuatorsApplications of Precise ActuatorsNonlinear Dynamics and ModelingHysteresisCreepFrictionForce RipplesIdentification and Compensation of Preisach Hysteresis in Piezoelectric ActuatorsSVD-Based Identification and Compensation of Preisach HysteresisHigh-Bandwidth Identification and Compensation of Hysteretic Dynamics in Piezoelectric ActuatorsConcluding RemarksIdentification and Compensation of Frict

  1. Alveolar bone measurement precision for phosphor-plate images

    Science.gov (United States)

    HILDEBOLT, CHARLES F.; COUTURE, REX; GARCIA, NATHALIA M.; DIXON, DEBRA; SHANNON, WILLIAM DOUGLAS; LANGENWALTER, ERIC; CIVITELLI, ROBERTO

    2009-01-01

    Objectives To demonstrate methods for determining measurement precision and to determine the precision of alveolar-bone measurements made with a vacuum-coupled, positioning device and phosphor-plate images. Study design Subjects were rigidly attached to the x-ray tube by means of a vacuum coupling device and custom, cross-arch, bite plates. Original and repeat radiographs (taken within minutes of each other) were obtained of the mandibular posterior teeth of 51 subjects, and cementoenamel-junction-alveolar-crest (CEJ-AC) distances were measured on both sets of images. In addition, x-ray-transmission (radiodensity) and alveolar-crest-height differences were determined by subtracting one image from the other. Image subtractions and measurements were performed twice. Based on duplicate measurements, the root-mean-square standard deviation (precision) and least-significant change (LSC) were calculated. LSC is the magnitude of change in a measurement needed to indicate that a true biological change has occurred. Results The LSCs were 4% for x-ray transmission, 0.49 mm for CEJ-AC distance, and 0.06 mm for crest-height 0.06 mm. Conclusion The LSCs for our CEJ-AC and x-ray transmission measurements are similar to what has been reported. The LSC for alveolar-crest height (determined with image subtraction) was less than 0.1 mm. Compared with findings from previous studies, this represents a highly precise measurement of alveolar crest height. The methods demonstrated for calculating LSC can be used by investigators to determine how large changes in radiographic measurements need to be before the changes can be considered (with 95% confidence) true biological changes and not noise (that is, equipment/observer error). PMID:19716499

  2. Analysis of Precision of Activation Analysis Method

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Nørgaard, K.

    1973-01-01

    The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T......, which is shown to be approximated by a χ2 distribution. Application of this test to the results of determinations of manganese in human serum by a method of established precision, led to the detection of airborne pollution of the serum during the sampling process. The subsequent improvement in sampling...... conditions was shown to give not only increased precision, but also improved accuracy of the results....

  3. Precision injection molding of freeform optics

    Science.gov (United States)

    Fang, Fengzhou; Zhang, Nan; Zhang, Xiaodong

    2016-08-01

    Precision injection molding is the most efficient mass production technology for manufacturing plastic optics. Applications of plastic optics in field of imaging, illumination, and concentration demonstrate a variety of complex surface forms, developing from conventional plano and spherical surfaces to aspheric and freeform surfaces. It requires high optical quality with high form accuracy and lower residual stresses, which challenges both optical tool inserts machining and precision injection molding process. The present paper reviews recent progress in mold tool machining and precision injection molding, with more emphasis on precision injection molding. The challenges and future development trend are also discussed.

  4. Precision Higgs boson measurement at CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)718111

    2016-01-01

    The design of the next generation collider in high energy physics will primarily focus on the possibility to achieve high precision of the measurements of interest. The necessary precision limits are set, in the first place, by the measurement of the Higgs boson but also by measurements that are sensitive to signs of New Physics. The Compact Linear Collider (CLIC) is an attractive option for a future multi-TeV linear electron-positron collider, with the potential to cover a rich physics program with high precision. In this lecture the CLIC accelerator, detector and backgrounds will be presented with emphesis on the capabilities of CLIC for precision Higgs physics.

  5. BONES, TEACHER'S GUIDE.

    Science.gov (United States)

    Elementary Science Study, Newton, MA.

    THIS GUIDE WAS DEVELOPED FOR USE WITH THE ELEMENTARY SCIENCE STUDY UNIT ON "BONES.""BONES" HAS BEEN TAUGHT IN THE FOURTH GRADE AND REQUIRES FROM 10 TO 25 LESSONS, DEPENDING ON THE NUMBER OF ACTIVITIES USED. THE GUIDE DOES NOT PROVIDE DETAILED INSTRUCTION FOR CONDUCTING CLASSES, BUT RATHER SOME POSSIBLE ACTIVITIES, AND LEAVES THE DAY-TO-DAY…

  6. Radiologic Technology Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This guide presents the standard curriculum for technical institutes in Georgia. The curriculum addresses the minimum competencies for a radiologic technology program. The guide contains four major sections. The General Information section contains an introduction giving an overview and defining purpose and objectives; a program description,…

  7. Irrigation Systems. Student's Guide.

    Science.gov (United States)

    Amarillo Coll., TX.

    This guide is intended for use by individuals preparing for a career in commercial and residential irrigation. The materials included are geared toward students who have had some experience in the irrigation business; they are intended to be presented in 10 six-hour sessions. The first two sections deal with using this guide and preparing for the…

  8. Irrigation Systems. Instructor's Guide.

    Science.gov (United States)

    Amarillo Coll., TX.

    This guide is intended for use by licensed irrigators who wish to teach others how to design and install residential and commercial irrigation systems. The materials included in the guide have been developed under the assumption that the instructors who use it have little or no formal training as teachers. The first section presents detailed…

  9. Instructional Guide for Cosmetology.

    Science.gov (United States)

    Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Education.

    Intended as a tool for cosmetology teachers in Virginia public and private schools, the document is an instructional guide which offers 12 units of study, arranged in a three year course. Materials covered help prepare students for licensure in the State of Virginia and the guide is designed to cover the 1,500 hours required to be spent in the…

  10. Measurement Practice Guide

    Science.gov (United States)

    College and Career Readiness and Success Center, 2014

    2014-01-01

    This discussion guide is part of a larger practice guide designed to help state education agencies (SEAs) define measurement goals, select college and career readiness measures and indicators designed to support those goals, and use the data gathered with those measures and indicators to make informed decisions about college and career readiness…

  11. Nutrition Guide for Toddlers

    Science.gov (United States)

    ... Old Feeding Your 1- to 2-Year-Old Nutrition Guide for Toddlers KidsHealth > For Parents > Nutrition Guide ... español Guía de nutrición para sus hijos pequeños Nutrition Through Variety Growth slows somewhat during the toddler ...

  12. The Higgs hunter's guide

    CERN Document Server

    Gunion, John F; Haber, Howard E; Kane, Gordon L

    1989-01-01

    The Higgs Hunter's Guide is a definitive and comprehensive guide to the physics of Higgs bosons. In particular, it discusses the extended Higgs sectors required by those recent theoretical approaches that go beyond the Standard Model, including supersymmetry and superstring-inspired models.

  13. JBoss ESB Beginner's Guide

    CERN Document Server

    DiMaggio, Len; Magesh, Kumar

    2012-01-01

    Part of Packt's Beginner's Guide series, each chapter contains practical examples with step-by-step instructions and plenty of screenshots to guide you through the implementation of JBoss ESB. This book is intended for Java programmers although you don't need previous experience with middleware such as application servers or ESBs.

  14. Guided Learning at Work.

    Science.gov (United States)

    Billett, Stephen

    2000-01-01

    Guided learning (questioning, diagrams/analogies, modeling, coaching) was studied through critical incident interviews in five workplaces. Participation in everyday work activities was the most effective contributor to workplace learning. Organizational readiness and the efficacy of guided learning in resolving novel tasks were also important. (SK)

  15. Medical Assisting Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This guide presents the standard curriculum for technical institutes in Georgia. The curriculum addresses the minimum competencies for a medical assisting program. The program guide is designed to relate primarily to the development of those skills needed by individuals in the medical assisting field, such as medical law and ethics, typing,…

  16. Marketing Education Curriculum Guide.

    Science.gov (United States)

    Michigan State Univ., East Lansing. Coll. of Agriculture and Natural Resources Education Inst.

    This curriculum guide is intended to provide a common core of competencies from which to design an effective secondary marketing education program. Introductory materials include a definition of marketing education, objectives, outline of instructional content, and questions and answers regarding the curriculum guide. These practical materials are…

  17. concrete5 Beginner's Guide

    CERN Document Server

    Laubacher, Remo

    2011-01-01

    This book is part of Packt's Beginner's Guide series. You will be guided through the set up of a Concrete5 site with step-by-step practical examples. This book is ideal for developers who would like to build their first site with Concrete5. Some k

  18. Precise resection of symptomatic occipital lobe epilepsy guided by functional neuronavigation combined with intra-operative magnetic resonance imaging%功能神经导航和术中核磁共振引导下症状性枕叶癫痫的精准外科治疗

    Institute of Scientific and Technical Information of China (English)

    刘智良; 戴宜武; 丁虎; 游宇; 刘建明; 孟繁鑫; 徐如祥

    2014-01-01

    Objective To evaluate the clinical effect of functional neuronavigation combined with intra-operative magnetic resonance imaging (iMRI) in resection of symptomatic occipital lobe epilepsy.Methods Sixteen patients with symptomatic occipital lobe epilepsy,admitted to our hospital from January 2011 to April 2012,were involved in present study.All patients underwent surgical operation assisted by functional neuronavigation.Before the operation,MRI scanning,imaging fusing,scope of lesion excision describing,and operative approach designing were performed successively.Three-D reconstructed navigation plan was integrated into neuronavigation system and used by combining with functional neuronavigation under microscope during the surgical procedure.And,the iMRI was performed in five of them; the operative plan of the residuary lesion was redesigned accordingly.After the operation,the regular clinical and iconography follow-up were in progress.Results The functional neuronavigation was successfully completed.The lesions,posterior central gyrus and pyramidal tracts were projected into operation microscope.The lesions were precisely excised,and the posterior central gyrus and pyramidal tracts were protected effectively.The last iMRI indicated that the range of resection was coincided with the pro-operative plan.During the follow-up of 12-24 months,11 patients were found to be completely seizure-free or with only aura (Engel I),and 5 patients had only rare seizure (Engel Ⅱ,fewer than three seizures per year).Nine patients appeared visual field defect without hemiparalysis or hemianesthesia.Conclusion Functional neuronavigation combined with iMRI is a safe and reliable technique for perfect resection of symptomatic occipital lobe epilepsy and reduction of normal brain functions by precisely locating lesions and important functional structures.%目的 评估功能神经导航和术中核磁共振(MRI)引导对症状性枕叶癫痫切除术的协助效果. 方法 回顾性分

  19. The use of circumferentially varying stagger guide vanes in an axial flow pump or compressor

    Science.gov (United States)

    Horlock, J. H.

    1990-04-01

    An actuator disk analysis is given of the flow through a guide vane and rotor combination. It is shown that changes in total pressure across the rotor are, in general, related to circumferential variations in guide vane outlet angle. In particular, known variations in inlet total pressure may be eliminated by suitable circumferential changes in guide vane stagger.

  20. 75 FR 5351 - Proposed Revisions to Accounting Guide for LSC Recipients

    Science.gov (United States)

    2010-02-02

    ...) other changes to clarify existing provisions. The proposed revisions to the Accounting Guide for LSC... Proposed Revisions to Accounting Guide for LSC Recipients AGENCY: Legal Services Corporation. ACTION... Accounting Guide for LSC Recipients to reflect changes that have occurred since the last publication of...

  1. TU-H-202-03: Spatial Distributions of Radiation Induced Pulmonary Changes Can Be Modeled and Utilized for Image-Guided Planning and Therapy to Improve Pulmonary Function Preservation and Hence the Therapeutic Ratio for Lung Cancer.

    Science.gov (United States)

    Bayouth, J

    2016-06-01

    CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images. CT ventilation imaging provides functional images that are higher resolution, faster and cheaper to perform than the clinical standard, SPECT. Indeed the number of CT ventilation abstracts presented at the AAPM meeting has been doubling every two years. With the world's-first clinical trial of CT ventilation functional image-guided radiation therapy now underway, the first dedicated scientific symposium will educate and stimulate AAPM members from both radiology and radiation oncology. This symposium will compare the foundations of CT ventilation imaging with competing MRI, PET and SPECT ventilation imaging methods, and details the first clinical trial of CT ventilation imaging for functional avoidance in lung cancer radiation therapy. The spatial-temporal nature of pulmonary ventilation, response maps to radiation and the design of predictive models will be presented. Validation efforts and challenges will also be discussed, from clinical outcome correlations in single time point and longitudinal studies, to cross-modality image comparisons in the first multi-institutional CT ventilation imaging challenge. The panel will discuss the future role of CT ventilation imaging, and what level of physiologic validation is needed for applications in radiation oncology and beyond.

  2. Radiation oncology in the era of precision medicine

    DEFF Research Database (Denmark)

    Baumann, Michael; Krause, Mechthild; Overgaard, Jens

    2016-01-01

    Technological advances and clinical research over the past few decades have given radiation oncologists the capability to personalize treatments for accurate delivery of radiation dose based on clinical parameters and anatomical information. Eradication of gross and microscopic tumours with prese...... image guidance and particle therapy, and novel biological concepts for personalized treatment, including biomarker-guided prescription, combined treatment modalities and adaptation of treatment during its course.......Technological advances and clinical research over the past few decades have given radiation oncologists the capability to personalize treatments for accurate delivery of radiation dose based on clinical parameters and anatomical information. Eradication of gross and microscopic tumours...... with preservation of health-related quality of life can be achieved in many patients. Two major strategies, acting synergistically, will enable further widening of the therapeutic window of radiation oncology in the era of precision medicine: technology-driven improvement of treatment conformity, including advanced...

  3. Adaptive Human Control Gains During Precision Grip

    Directory of Open Access Journals (Sweden)

    Erik D. Engeberg

    2013-03-01

    Full Text Available Eight human test subjects attempted to track a desired position trajectory with an instrumented manipulandum (MN. The test subjects used the MN with three different levels of stiffness. A transfer function was developed to represent the human application of a precision grip from the data when the test subjects initially displaced the MN so as to learn the position mapping from the MN onto the display. Another transfer function was formed from the data of the remainder of the experiments, after significant displacement of the MN occurred. Both of these transfer functions accurately modelled the system dynamics for a portion of the experiments, but neither was accurate for the duration of the experiments because the human grip dynamics changed while learning the position mapping. Thus, an adaptive system model was developed to describe the learning process of the human test subjects as they displaced the MN in order to gain knowledge of the position mapping. The adaptive system model was subsequently validated following comparison with the human test subject data. An examination of the average absolute error between the position predicted by the adaptive model and the actual experimental data yielded an overall average error of 0.34mm for all three levels of stiffness.

  4. Precise genome editing by homologous recombination.

    Science.gov (United States)

    Hoshijima, K; Jurynec, M J; Grunwald, D J

    2016-01-01

    Simple and efficient methods are presented for creating precise modifications of the zebrafish genome. Edited alleles are generated by homologous recombination between the host genome and double-stranded DNA (dsDNA) donor molecules, stimulated by the induction of double-strand breaks at targeted loci in the host genome. Because several kilobase-long tracts of sequence can be exchanged, multiple genome modifications can be generated simultaneously at a single locus. Methods are described for creating: (1) alleles with simple sequence changes or in-frame additions, (2) knockin/knockout alleles that express a reporter protein from an endogenous locus, and (3) conditional alleles in which exons are flanked by recombinogenic loxP sites. Significantly, our approach to genome editing allows the incorporation of a linked reporter gene into the donor sequences so that successfully edited alleles can be identified by virtue of expression of the reporter. Factors affecting the efficiency of genome editing are discussed, including the finding that dsDNA products of I-SceI meganuclease enzyme digestion are particularly effective as donor molecules for gene-editing events. Reagents and procedures are described for accomplishing efficient genome editing in the zebrafish.

  5. Design of the Mechanical Parts for the Neutron Guide System at HANARO

    Science.gov (United States)

    Shin, J. W.; Cho, Y. G.; Cho, S. J.; Ryu, J. S.

    2008-03-01

    The research reactor HANARO (High-flux Advanced Neutron Application ReactOr) in Korea will be equipped with a neutron guide system, in order to transport cold neutrons from the neutron source to the neutron scattering instruments in the neutron guide hall near the reactor building. The neutron guide system of HANARO consists of the in-pile plug assembly with in-pile guides, the primary shutter with in-shutter guides, the neutron guides in the guide shielding room with dedicated secondary shutters, and the neutron guides connected to the instruments in the neutron guide hall. Functions of the in-pile plug assembly are to shield the reactor environment from nuclear radiation and to support the neutron guides and maintain them precisely oriented. The primary shutter is a mechanical structure to be installed just after the in-pile plug assembly, which stops neutron flux on demand. This paper describes the design of the in-pile assembly and the primary shutter for the neutron guide system at HANARO. The design of the guide shielding assembly for the primary shutter and the neutron guides is also presented.

  6. Ultra-precision processes for optics manufacturing

    Science.gov (United States)

    Martin, William R.

    1991-12-01

    The Optics MODIL (Manufacturing Operations Development and Integration Laboratory) is developing advanced manufacturing technologies for fabrication of ultra precision optical components, aiming for a ten-fold improvement in precision and a shortening of the scheduled lead time. Current work focuses on diamond single point turning, ductile grinding, ion milling, and in/on process metrology.

  7. Usefulness of Models in Precision Nutrient Management

    DEFF Research Database (Denmark)

    Plauborg, Finn; Manevski, Kiril; Zhenjiang, Zhou

    and mineral composition. Mapping of crop status and the spatial-temporal variability within fields with red-infrared reflection are used to support decision on split fertilisation and more precise dosing. The interpretation and use of these various data in precise nutrient management is not straightforward...

  8. High precision laser forming for micro actuation

    NARCIS (Netherlands)

    Folkersma, Ger K.G.P.; Römer, G.R.B.E.; Brouwer, D.M.; Huis in 't Veld, A.J.; Nakata, Yoshiki; Xu, Xianfan; Roth, Stephan; Neuenschwander, Beat

    2014-01-01

    For assembly of micro-devices, such as photonic devices, the precision alignment of components is often critical for their performance. Laser forming, also known as laser-adjusting, can be used to create an integrated microactuator to align the components with sub-micron precision after bonding. In

  9. Guided image filtering.

    Science.gov (United States)

    He, Kaiming; Sun, Jian; Tang, Xiaoou

    2013-06-01

    In this paper, we propose a novel explicit image filter called guided filter. Derived from a local linear model, the guided filter computes the filtering output by considering the content of a guidance image, which can be the input image itself or another different image. The guided filter can be used as an edge-preserving smoothing operator like the popular bilateral filter [1], but it has better behaviors near edges. The guided filter is also a more generic concept beyond smoothing: It can transfer the structures of the guidance image to the filtering output, enabling new filtering applications like dehazing and guided feathering. Moreover, the guided filter naturally has a fast and nonapproximate linear time algorithm, regardless of the kernel size and the intensity range. Currently, it is one of the fastest edge-preserving filters. Experiments show that the guided filter is both effective and efficient in a great variety of computer vision and computer graphics applications, including edge-aware smoothing, detail enhancement, HDR compression, image matting/feathering, dehazing, joint upsampling, etc.

  10. Special techniques in ultra-precision machining

    Science.gov (United States)

    Li, Li; Min, Xu; Chen, Dong; Wang, JunHua

    2007-12-01

    As the development of ultra-precision machining, the SPDT (single point diamond turning) was applied for the manufacture of a variety of optical components for its high precision , versatility and lower manufacturing cost. Whereas, the improvement of ultra-precision machining is not only related to the most topnotch equipments in the world but also closely linked to the special techniques in the ultra-precision Machining. Therefore, the industrialization and marketization of the ultra-precision machining will not be realized without these special techniques. This paper introduces the principle, trait and application of some important special techniques which can match the SPDT efficaciously, they are FTS, STS, SSS, ACT, VQ, LADT and UADT techniques.

  11. Precision Measurement Physics and Its Methodology

    Institute of Scientific and Technical Information of China (English)

    Chao-hui YE; Jia-ming LI; Jun LUO

    2009-01-01

    @@ Precision Measurement Physics deals with the frontier problems in science, and plays a multi-disciplinary and fundamental role in strongly advancing the sciences. It is well known that an improvement of measuring precision in physics by an order of magnitude often implies a new or unknown effect to be explored, consequently even a new physical law to be established. There is no doubt that the development of modern physics is so closely related to precision measurements. During the past few decades, the methodologies and physics of precision measurements have achieved tremendous breakthroughs, and therefore have extended our understanding of the physics world.In addition, some technologies developed in this process have been applied in our daily life. Also, we can expect Precision Measurement Physics to make more significant progress toward verifying the basic laws of physics, and to find more practical applications in the future.

  12. Precision surveying the principles and geomatics practice

    CERN Document Server

    Ogundare, John Olusegun

    2016-01-01

    A comprehensive overview of high precision surveying, including recent developments in geomatics and their applications This book covers advanced precision surveying techniques, their proper use in engineering and geoscience projects, and their importance in the detailed analysis and evaluation of surveying projects. The early chapters review the fundamentals of precision surveying: the types of surveys; survey observations; standards and specifications; and accuracy assessments for angle, distance and position difference measurement systems. The book also covers network design and 3-D coordinating systems before discussing specialized topics such as structural and ground deformation monitoring techniques and analysis, mining surveys, tunneling surveys, and alignment surveys. Precision Surveying: The Principles and Geomatics Practice: * Covers structural and ground deformation monitoring analysis, advanced techniques in mining and tunneling surveys, and high precision alignment of engineering structures *...

  13. Guidebook for territories' support in the analysis of their socio-economical vulnerability to climate change; Guide d'accompagnement des territoires pour l'analyse de leur vulnerabilite socio-economique au changement climatique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The work of the inter-ministerial group 'Impacts of Climate Change, Adaptation and Associated Costs for France', which met between March 2007 and October 2009, led to a sector-based assessment of all climate change related impacts and of associated adaptation measures. The aim was to obtain quantified elements that could underpin public policy decision-making and especially development of the National Adaptation Plan. While the sectoral analyses focused on quantifying the costs of adaptation, the approach of the 'Territories' group, co-steered by the Datar (regional development delegation) and Ademe (agency for energy management and environment), addressed the subject of interactions between players and activities, both spatial (sharing of resources between different uses, etc.) and temporal (transition from one situation to another, etc.) and the corresponding means for adjustment. It was in this context that the SOeS proposed a methodology for diagnosis of the socio-economic vulnerability of a given sub-national territory in the face of climate change. This document provides a broad-brush outline of the accompanying guidelines developed by Sogreah Consultants SAS for use by local players. A three step approach is followed to draw up the vulnerability profile of a territory: 1 - characterising the territory by the identification of the priority activities and physical features; 2 - using the analysis tools to produce a matrix of indices of vulnerability to climate change per hazard; 3 - drawing up an initial vulnerability profile by bringing together the information from the matrix and that from feedback, either by activity or group of activities, or by environment, depending on aims. The profile leads to identification of the important issues as well as allowing identification of potential impacts to be studied in more depth. Guidelines were tested in three pilot territories facing different climate change issues: Wateringues, in the Nord

  14. Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions.

    Science.gov (United States)

    Lo, Te-Wen; Pickle, Catherine S; Lin, Steven; Ralston, Edward J; Gurling, Mark; Schartner, Caitlin M; Bian, Qian; Doudna, Jennifer A; Meyer, Barbara J

    2013-10-01

    Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their complexity. DSBs can trigger either error-prone repair pathways that induce random mutations at the break sites or precise homology-directed repair pathways that generate specific insertions or deletions guided by exogenously supplied DNA. Prior editing strategies using site-specific nucleases to modify the Caenorhabditis elegans genome achieved only the heritable disruption of endogenous loci through random mutagenesis by error-prone repair. Here we report highly effective strategies using TALE nucleases and RNA-guided CRISPR/Cas9 nucleases to induce error-prone repair and homology-directed repair to create heritable, precise insertion, deletion, or substitution of specific DNA sequences at targeted endogenous loci. Our robust strategies are effective across nematode species diverged by 300 million years, including necromenic nematodes (Pristionchus pacificus), male/female species (Caenorhabditis species 9), and hermaphroditic species (C. elegans). Thus, genome-editing tools now exist to transform nonmodel nematode species into genetically tractable model organisms. We demonstrate the utility of our broadly applicable genome-editing strategies by creating reagents generally useful to the nematode community and reagents specifically designed to explore the mechanism and evolution of X chromosome dosage compensation. By developing an efficient pipeline involving germline injection of nuclease mRNAs and single-stranded DNA templates, we engineered precise, heritable nucleotide changes both close to and far from DSBs to gain or lose genetic function, to tag proteins made from endogenous genes, and to excise entire loci through targeted FLP-FRT recombination.

  15. 2014 Australasian sky guide

    CERN Document Server

    Lomb, Nick

    2013-01-01

    Compact, easy to use and reliable, this popular guide contains everything you need to know about the southern night sky with monthly astronomy maps, viewing tips and highlights, and details of all the year's exciting celestial events. Wherever you are in Australia or New Zealand, easy calculations allow you to estimate local rise and set times for the Sun, Moon and planets. The 2014 Australasian Sky Guide also provides information on the solar system, updated with the latest findings from space probes. Published annually since 1991, the Sky Guide continues to be a favourite with photographers,

  16. CCNA Wireless Study Guide

    CERN Document Server

    Lammle, Todd

    2010-01-01

    A complete guide to the CCNA Wireless exam by leading networking authority Todd Lammle. The CCNA Wireless certification is the most respected entry-level certification in this rapidly growing field. Todd Lammle is the undisputed authority on networking, and this book focuses exclusively on the skills covered in this Cisco certification exam. The CCNA Wireless Study Guide joins the popular Sybex study guide family and helps network administrators advance their careers with a highly desirable certification.: The CCNA Wireless certification is the most respected entry-level wireless certification

  17. Robotic System for Precision Assembly of NIF Ignition Targets

    Energy Technology Data Exchange (ETDEWEB)

    Montesanti, R C; Seugling, R M; Klingmann, J L; Dzenitis, E G; Alger, E T; Miller, G L; Kent, R A; Castro, C; Reynolds, J L; Carrillo, M A

    2008-08-27

    This paper provides an overview of the design and testing of a robotic system developed for assembling the inertial confinement fusion ignition targets (depicted in Figures 1 and 2) that will be fielded on the National Ignition Facility (NIF) laser [1]. The system, referred to as the Final Assembly Machine and shown in Figure 3, consists of six groups of stacked axes that allow manipulating millimeter-sized components with submicron precision, integrated with an optical coordinate measuring machine (OCMM) that provides in-situ metrology. Nineteen motorized axes and ten manual axes are used to control the position and orientation of five objects that are predominantly assembled together in a cubic centimeter work zone. An operator-in-the-loop provides top-level control of the system, making it more similar to a surgical robot than to a programmed computer-controlled machine tool. The operator is provided visual feedback by the vision system of the OCMM, and tactile feedback by force and torque sensors embedded in the tooling that holds the major components being assembled. The vision system is augmented with auxiliary mirrors providing multiple viewing directions, and is used to guide the approach and alignment of the components, and to measure the relative position and orientation of the components. The force and torque sensors are used to guide the final approach, alignment, and mating of the components that are designed to slip-fit together, and to monitor that mating while adhesively bonding those components and attaching the target base.

  18. Persuading consumers to form precise search engine queries.

    Science.gov (United States)

    Leroy, Gondy

    2009-11-14

    Today's search engines provide a single textbox for searching. This input method has not changed in decades and, as a result, consumer search behaviour has not changed either: few and imprecise keywords are used. Especially with health information, where incorrect information may lead to unwise decisions, it would be beneficial if consumers could search more precisely. We evaluated a new user interface that supports more precise searching by using query diagrams. In a controlled user study, using paper-based prototypes, we compared searching with a Google interface with drawing new or modifying template diagrams. We evaluated consumer willingness and ability to use diagrams and the impact on query formulation. Users had no trouble understanding the new search method. Moreover, they used more keywords and relationships between keywords with search diagrams. In comparison to drawing their own diagrams, modifying existing templates led to more searches being conducted and higher creativity in searching.

  19. Biobanking shifts to “precision medicine”

    OpenAIRE

    2014-01-01

    Aikaterini Ntai,1 Simona Baronchelli,2 Tatiana Pellegrino,1 Pasquale De Blasio,1 Ida Biunno2,3 1Integrated Systems Engineering, Milan, Italy; 2Institute for Genetic and Biomedical Research, National Research Council, Milan, Italy; 3IRCCS Multimedica, Milan, Italy Abstract: The shape of the global health care system is changing rapidly to an approach that is much more patient-centered and focused on “precision medicine.” This is especially due to the development of large-s...

  20. Advanced structural design for precision radial velocity instruments

    Science.gov (United States)

    Baldwin, Dan; Szentgyorgyi, Andrew; Barnes, Stuart; Bean, Jacob; Ben-Ami, Sagi; Brennan, Patricia; Budynkiewicz, Jamie; Chun, Moo-Young; Conroy, Charlie; Crane, Jeffrey D.; Epps, Harland; Evans, Ian; Evans, Janet; Foster, Jeff; Frebel, Anna; Gauron, Thomas; Guzman, Dani; Hare, Tyson; Jang, Bi-Ho; Jang, Jeong-Gyun; Jordan, Andres; Kim, Jihun; Kim, Kang-Min; Mendes de Oliveira, Claudia; Lopez-Morales, Mercedes; McCracken, Kenneth; McMuldroch, Stuart; Miller, Joseph; Mueller, Mark; Oh, Jae Sok; Ordway, Mark; Park, Byeong-Gon; Park, Chan; Park, Sung-Joon; Paxson, Charles; Phillips, David; Plummer, David; Podgorski, William; Seifahrt, Andreas; Stark, Daniel; Steiner, Joao; Uomoto, Alan; Walsworth, Ronald; Yu, Young-Sam

    2016-07-01

    The GMT-Consortium Large Earth Finder (G-CLEF) is an echelle spectrograph with precision radial velocity (PRV) capability that will be a first light instrument for the Giant Magellan Telescope (GMT). G-CLEF has a PRV precision goal of 40 cm/sec (10 cm/s for multiple measurements) to enable detection of Earth-like exoplanets in the habitable zones of sun-like stars1. This precision is a primary driver of G-CLEF's structural design. Extreme stability is necessary to minimize image motions at the CCD detectors. Minute changes in temperature, pressure, and acceleration environments cause structural deformations, inducing image motions which degrade PRV precision. The instrument's structural design will ensure that the PRV goal is achieved under the environments G-CLEF will be subjected to as installed on the GMT azimuth platform, including: Millikelvin (0.001 °K) thermal soaks and gradients 10 millibar changes in ambient pressure Changes in acceleration due to instrument tip/tilt and telescope slewing Carbon fiber/cyanate composite was selected for the optical bench structure in order to meet performance goals. Low coefficient of thermal expansion (CTE) and high stiffness-to-weight are key features of the composite optical bench design. Manufacturability and serviceability of the instrument are also drivers of the design. In this paper, we discuss analyses leading to technical choices made to minimize G-CLEF's sensitivity to changing environments. Finite element analysis (FEA) and image motion sensitivity studies were conducted to determine PRV performance under operational environments. We discuss the design of the optical bench structure to optimize stiffness-to-weight and minimize deformations due to inertial and pressure effects. We also discuss quasi-kinematic mounting of optical elements and assemblies, and optimization of these to ensure minimal image motion under thermal, pressure, and inertial loads expected during PRV observations.

  1. Atomically precise gold nanocrystal molecules with surface plasmon resonance.

    Science.gov (United States)

    Qian, Huifeng; Zhu, Yan; Jin, Rongchao

    2012-01-17

    Since Faraday's pioneering work on gold colloids, tremendous scientific research on plasmonic gold nanoparticles has been carried out, but no atomically precise Au nanocrystals have been achieved. This work reports the first example of gold nanocrystal molecules. Mass spectrometry analysis has determined its formula to be Au(333)(SR)(79) (R = CH(2)CH(2)Ph). This magic sized nanocrystal molecule exhibits fcc-crystallinity and surface plasmon resonance at approximately 520 nm, hence, a metallic nanomolecule. Simulations have revealed that atomic shell closing largely contributes to the particular robustness of Au(333)(SR)(79), albeit the number of free electrons (i.e., 333 - 79 = 254) is also consistent with electron shell closing based on calculations using a confined free electron model. Guided by the atomic shell closing growth mode, we have also found the next larger size of extraordinarily stability to be Au(~530)(SR)(~100) after a size-focusing selection--which selects the robust size available in the starting polydisperse nanoparticles. This work clearly demonstrates that atomically precise nanocrystal molecules are achievable and that the factor of atomic shell closing contributes to their extraordinary stability compared to other sizes. Overall, this work opens up new opportunities for investigating many fundamental issues of nanocrystals, such as the formation of metallic state, and will have potential impact on condensed matter physics, nanochemistry, and catalysis as well.

  2. The Too-Much-Precision Effect.

    Science.gov (United States)

    Loschelder, David D; Friese, Malte; Schaerer, Michael; Galinsky, Adam D

    2016-12-01

    Past research has suggested a fundamental principle of price precision: The more precise an opening price, the more it anchors counteroffers. The present research challenges this principle by demonstrating a too-much-precision effect. Five experiments (involving 1,320 experts and amateurs in real-estate, jewelry, car, and human-resources negotiations) showed that increasing the precision of an opening offer had positive linear effects for amateurs but inverted-U-shaped effects for experts. Anchor precision backfired because experts saw too much precision as reflecting a lack of competence. This negative effect held unless first movers gave rationales that boosted experts' perception of their competence. Statistical mediation and experimental moderation established the critical role of competence attributions. This research disentangles competing theoretical accounts (attribution of competence vs. scale granularity) and qualifies two putative truisms: that anchors affect experts and amateurs equally, and that more precise prices are linearly more potent anchors. The results refine current theoretical understanding of anchoring and have significant implications for everyday life.

  3. [Precision Nursing: Individual-Based Knowledge Translation].

    Science.gov (United States)

    Chiang, Li-Chi; Yeh, Mei-Ling; Su, Sui-Lung

    2016-12-01

    U.S. President Obama announced a new era of precision medicine in the Precision Medicine Initiative (PMI). This initiative aims to accelerate the progress of personalized medicine in light of individual requirements for prevention and treatment in order to improve the state of individual and public health. The recent and dramatic development of large-scale biologic databases (such as the human genome sequence), powerful methods for characterizing patients (such as genomics, microbiome, diverse biomarkers, and even pharmacogenomics), and computational tools for analyzing big data are maximizing the potential benefits of precision medicine. Nursing science should follow and keep pace with this trend in order to develop empirical knowledge and expertise in the area of personalized nursing care. Nursing scientists must encourage, examine, and put into practice innovative research on precision nursing in order to provide evidence-based guidance to clinical practice. The applications in personalized precision nursing care include: explanations of personalized information such as the results of genetic testing; patient advocacy and support; anticipation of results and treatment; ongoing chronic monitoring; and support for shared decision-making throughout the disease trajectory. Further, attention must focus on the family and the ethical implications of taking a personalized approach to care. Nurses will need to embrace the paradigm shift to precision nursing and work collaboratively across disciplines to provide the optimal personalized care to patients. If realized, the full potential of precision nursing will provide the best chance for good health for all.

  4. Toward precision medicine in Alzheimer's disease.

    Science.gov (United States)

    Reitz, Christiane

    2016-03-01

    In Western societies, Alzheimer's disease (AD) is the most common form of dementia and the sixth leading cause of death. In recent years, the concept of precision medicine, an approach for disease prevention and treatment that is personalized to an individual's specific pattern of genetic variability, environment and lifestyle factors, has emerged. While for some diseases, in particular select cancers and a few monogenetic disorders such as cystic fibrosis, significant advances in precision medicine have been made over the past years, for most other diseases precision medicine is only in its beginning. To advance the application of precision medicine to a wider spectrum of disorders, governments around the world are starting to launch Precision Medicine Initiatives, major efforts to generate the extensive scientific knowledge needed to integrate the model of precision medicine into every day clinical practice. In this article we summarize the state of precision medicine in AD, review major obstacles in its development, and discuss its benefits in this highly prevalent, clinically and pathologically complex disease.

  5. NASA Guided Dropsonde Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Exquadrum, Inc. proposes to demonstrate the feasibility of an innovative approach to providing NASA with a Guided Dropsonde (NGD). NASA's desire to use existing...

  6. EERE Peer Review Guide

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-01-18

    The primary purpose of this guide is to provide managers and staff guidance in establishing formal in-progress peer review that provides intellectually fair expert evaluation of EERE RD3 and supporting business administration programs, both retrospective and prospective.

  7. Kenai Wilderness Management Guide

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Kenai Wilderness Management Guide is a description, interpretation, and synthesis of Congressional legislation, Department of the Interior regulation, and Fish...

  8. Guide to Insulating Sheathing

    Energy Technology Data Exchange (ETDEWEB)

    None

    2007-10-11

    This guide examines new methods of enclosure designs that provide high thermal performance and long-term durability but also take opportunities to reduce material use, simplify or integrate systems and details, and potentially reduce overall initial costs of construction.

  9. Ultrasound guided supraclavicular block.

    LENUS (Irish Health Repository)

    Hanumanthaiah, Deepak

    2013-09-01

    Ultrasound guided regional anaesthesia is becoming increasingly popular. The supraclavicular block has been transformed by ultrasound guidance into a potentially safe superficial block. We reviewed the techniques of performing supraclavicular block with special focus on ultrasound guidance.

  10. Urban Agriculture Guide

    NARCIS (Netherlands)

    Visser, A.J.; Jansma, J.E.; Dekking, A.J.G.; Klieverik, M.J.M.

    2007-01-01

    The Urban Agriculture Guide describes the experiences, learning moments, tips and tricks of those involved in the initiatives of urban agriculture and an indication is provided of what is required to develop urban agriculture further in the Netherlands

  11. Liferay Beginner's Guide

    CERN Document Server

    Chen, Robert; Bhatt, Samir

    2011-01-01

    Part of Packt's Beginner's Guide series, each chapter follows the creation of a fictional neighbourhood site to demonstrate an aspect of Liferay portal with practical examples, screenshots, and step-by-step instructions. All you need in order to benefit from the Liferay Beginner's Guide is programming experience. No prior knowledge of Liferay is required, although experienced Liferay portal programmers who need to get up to speed with its latest features will also find this book useful.

  12. Security guide for subcontractors

    Energy Technology Data Exchange (ETDEWEB)

    Adams, R.C.

    1991-01-01

    This security guide of the Department of Energy covers contractor and subcontractor access to DOE and Mound facilities. The topics of the security guide include responsibilities, physical barriers, personnel identification system, personnel and vehicular access controls, classified document control, protecting classified matter in use, storing classified matter repository combinations, violations, security education clearance terminations, security infractions, classified information nondisclosure agreement, personnel security clearances, visitor control, travel to communist-controlled or sensitive countries, shipment security, and surreptitious listening devices.

  13. Hand deburring guide

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, L.K.

    1979-07-01

    Appropriate hand deburring techniques have always been difficult to define because of the infinite variety of part shapes, sizes, materials, and burr conditions. This guide, however, has been prepared to assist those responsible for hand deburring. The purpose of the guide is to define Bendix Kansas City burr specifications and inspection practices; to define the results of practical tests on hand deburring; to define some typical in-house practices; and to define the in-house tools available for this work.

  14. VOLTTRON: User Guide

    Energy Technology Data Exchange (ETDEWEB)

    Lutes, Robert G.; Katipamula, Srinivas; Akyol, Bora A.; Tenney, Nathan D.; Haack, Jereme N.; Monson, Kyle E.; Carpenter, Brandon J.

    2014-04-24

    This document is a user guide for the deployment of the Transactional Network platform and agent/application development within the VOLTTRON. The intent of this user guide is to provide a description of the functionality of the Transactional Network Platform. This document describes how to deploy the platform, including installation, use, guidance, and limitations. It also describes how additional features can be added to enhance its current functionality.

  15. Railo 3 Beginner's Guide

    CERN Document Server

    Drew, Mark

    2011-01-01

    Part of Packt's Beginner's Guide series, this book uses practical examples and screenshots to steadily guide the reader through setting up and using Railo. If you want to develop your own dynamic web applications using CFML, then this book is for you. No prior experience with Railo or CFML is required, although you will be expected to have some web application development experience and knowledge of HTML.

  16. Wind Energy Teachers Guide

    Energy Technology Data Exchange (ETDEWEB)

    anon.

    2003-01-01

    This guide, created by the American Wind Association, with support from the U.S. Department of Energy, is a learning tool about wind energy targeted toward grades K-12. The guide provides teacher information, ideas for sparking children's and students' interest, suggestions for activities to undertake in and outside the classroom, and research tools for both teachers and students. Also included is an additional resources section.

  17. Guide for a typewriter

    Science.gov (United States)

    Dubois, R. D.; Pinson, G. T. (Inventor)

    1976-01-01

    The invention relates to accessories for typewriters, and more particularly to an improved guide for use in aligning a sheet of paper preparatory to an application of typed indicia to selected spaces. The device includes an aligning plate pivotally mounted on a line guide having formed therein a plurality of aligned apertures. The plate is so positioned that an aperture is positioned immediately above a target area for a type slug so that a slug will imprint a character in selected spaces.

  18. Visual explorer facilitator's guide

    CERN Document Server

    Palus, Charles J

    2010-01-01

    Grounded in research and practice, the Visual Explorer™ Facilitator's Guide provides a method for supporting collaborative, creative conversations about complex issues through the power of images. The guide is available as a component in the Visual Explorer Facilitator's Letter-sized Set, Visual Explorer Facilitator's Post card-sized Set, Visual Explorer Playing Card-sized Set, and is also available as a stand-alone title for purchase to assist multiple tool users in an organization.

  19. Precision requirements do not affect the allocation of visual working memory capacity.

    Science.gov (United States)

    He, Xu; Zhang, Weiwei; Li, Cuihong; Guo, Chunyan

    2015-03-30

    There has been a debate about whether allocation of visual working memory (VWM) capacity was flexible. One of the key points about this issue is whether complexity has an effect on the capacity, and one of the critical features of complex objects is higher requirements on the encoding precision than simple objects. Thus we investigated the influence of precision requirements on the allocation of VWM capacity resources, by comparing VWM capacity under different levels of sample-test similarity in a change-detection task. If the VWM capacity is limited by a fixed number of items, then the capacity should not be affected by precision requirements; however, if the capacity is allocated flexibly, then precision requirements should influence the capacity. Cowan's K and amplitude of contralateral delay activity (CDA) were used as behavioral and neurophysiological measures of VWM capacity, respectively. Cowan's K for high-precision discrimination was calculated on the basis of the accuracy of a small number of large-change trials inserted into high-precision blocks. This approach avoided the confounder of different test-phase difficulties between the low- and high-precision conditions and controlled for errors during the test phase. The results showed no effect of precision requirements on VWM capacity. However, analysis of the late positive component (LPC) amplitude indicated that higher precision requirements indeed caused more top-down control over VWM retention. These results support the hypothesis that VWM is limited by a fixed number of items.

  20. Positioning Precision Analysis of GNSS Multi-frequency Carrier Phase Combinations

    Institute of Scientific and Technical Information of China (English)

    WU Yue; PAN Yong; FAN Yimin; WANG Xiaojun

    2007-01-01

    GPS positioning precision is affected by various error sources, and traditional combinations of GPS carrier phase observations have their own limitations such as the wide-lane, the narrow-lane and the ionospheric-free combinations. To obtain the optimal positioning precision, a new linear combination method is addressed through the variance-covariance (VCV)of the GPS multi-frequency carrier phase combination equations, and the impact of the positioning precision is analyzed with the changing of the observation errors deduced by the law of error propagation. For the high precision positioning with only one carrier phase combination, the optimal combination method is deduced and further validated by an example of a baseline resolution with 60 km length. The result indicates that this method is the simplest, and the positioning precision is the best. Therefore, it is useful for long baseline quick positioning for different precision requirements in various distances.

  1. Precision measurement for particle physics and cosmology

    Science.gov (United States)

    Graham, Peter

    2017-01-01

    Axions and other light particles are strongly motivated. For example, the axion is the crucial element in the recently proposed solution to the hierarchy problem using dynamical relaxation in the early universe. However, such particles are challenging to search for experimentally. Precision measurement technologies such as atom interferometry, nuclear magnetic resonance, high precision magnetometry, and torsion balances allow novel, highly sensitive experiments for direct detection of such light dark matter and of gravitational waves. Thus precision measurement technologies open new avenues for probing the origin and composition of the universe.

  2. Precision gauge unification in the MSSM

    Energy Technology Data Exchange (ETDEWEB)

    Raby, Stuart, E-mail: raby@pacific.mps.ohio-state.ed [Department of Physics, Ohio State University, 191 W. Woodruff Ave, Columbus, OH 43210 (United States); Ratz, Michael, E-mail: mratz@ph.tum.d [Physik-Department T30, Technische Universitaet Muenchen, James-Franck-Strasse, 85748 Garching (Germany); Schmidt-Hoberg, Kai, E-mail: kai.schmidt-hoberg@ph.tum.d [Physik-Department T30, Technische Universitaet Muenchen, James-Franck-Strasse, 85748 Garching (Germany)

    2010-04-19

    We discuss the issue of precision gauge unification in the MSSM. We find that a comparably light gluino, as it emerges in certain patterns of soft supersymmetry breaking, can be a key ingredient for ensuring precision gauge unification without relying on the presence of extra particles around the scale of grand unification. In particular, the so-called mirage pattern for gaugino masses can naturally lead to precision gauge unification. There is also an interesting correlation with reduced fine-tuning, due to rather light gluinos.

  3. Precision spectroscopy of the helium atom

    Institute of Scientific and Technical Information of China (English)

    Shui-ming HU; Zheng-Tian LU; Zong-Chao YAN

    2009-01-01

    Persistent efforts in both theory and experiment have yielded increasingly precise understanding of the helium atom. Because of its simplicity, the helium atom has long been a testing ground for relativistic and quantum electrodynamic effects in few-body atomic systems theoretically and experimentally.Comparison between theory and experiment of the helium spectroscopy in ls2p3pJ can potentially extract a very precise value of the fine structure constant a. The helium atom can also be used to explore exotic nuclear structures. In this paper, we provide a brief review of the recent advances in precision calculations and measurements of the helium atom.

  4. Mixed-Precision Spectral Deferred Correction: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Grout, Ray W. S.

    2015-09-02

    Convergence of spectral deferred correction (SDC), where low-order time integration methods are used to construct higher-order methods through iterative refinement, can be accelerated in terms of computational effort by using mixed-precision methods. Using ideas from multi-level SDC (in turn based on FAS multigrid ideas), some of the SDC correction sweeps can use function values computed in reduced precision without adversely impacting the accuracy of the final solution. This is particularly beneficial for the performance of combustion solvers such as S3D [6] which require double precision accuracy but are performance limited by the cost of data motion.

  5. The forthcoming era of precision medicine.

    Science.gov (United States)

    Gamulin, Stjepan

    2016-11-01

    The aim of this essay is to present the definition and principles of personalized or precision medicine, the perspective and barriers to its development and clinical application. The implementation of precision medicine in health care requires the coordinated efforts of all health care stakeholders (the biomedical community, government, regulatory bodies, patients' groups). Particularly, translational research with the integration of genomic and comprehensive data from all levels of the organism ("big data"), development of bioinformatics platforms enabling network analysis of disease etiopathogenesis, development of a legislative framework for handling personal data, and new paradigms of medical education are necessary for successful application of the concept of precision medicine in health care.

  6. Precision medicine in patients with allergic diseases

    DEFF Research Database (Denmark)

    Muraro, Antonella; Lemanske, Robert F; Hellings, Peter W

    2016-01-01

    of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction...... their translation into pathway-specific diagnostic tests. Wide consensus between academia, governmental regulators, and industry for further development and application of precision medicine in management of allergic diseases is of utmost importance. Improved knowledge of disease pathogenesis together with defining...... validated and qualified biomarkers are key approaches to precision medicine....

  7. Workshop on Precision Measurements of alphas

    CERN Document Server

    Bethke, S; Kluth, S; Schieck, J; Stewart, I W; Aoki, S; Beneke, M; Blumlein, J; Brambilla, N; Brodsky, S; Descotes-Genon, S; Erler, J; Forte, S; Gehrmann, T; Golterman, M; Hashimoto, S; Kronfeld, A; Kuhn, J; Lepage, P; Martin, A; Mateu, V; Menke, S; Nomura, Y; Pahl, C; Petriello, F; Pich, A; Rabbertz, K; Salam, G; Schulz, H; Sommer, R; Steinhauser, M; Webber, B; Yuan, CP; Zanderighi, G

    2011-01-01

    These are the proceedings of the "Workshop on Precision Measurements of alphas" held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of alphas(mZ) in the MS-bar scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, tau-decays, electroweak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.

  8. Control system design guide

    Energy Technology Data Exchange (ETDEWEB)

    Sellers, David; Friedman, Hannah; Haasl, Tudi; Bourassa, Norman; Piette, Mary Ann

    2003-05-01

    The ''Control System Design Guide'' (Design Guide) provides methods and recommendations for the control system design process and control point selection and installation. Control systems are often the most problematic system in a building. A good design process that takes into account maintenance, operation, and commissioning can lead to a smoothly operating and efficient building. To this end, the Design Guide provides a toolbox of templates for improving control system design and specification. HVAC designers are the primary audience for the Design Guide. The control design process it presents will help produce well-designed control systems that achieve efficient and robust operation. The spreadsheet examples for control valve schedules, damper schedules, and points lists can streamline the use of the control system design concepts set forth in the Design Guide by providing convenient starting points from which designers can build. Although each reader brings their own unique questions to the text, the Design Guide contains information that designers, commissioning providers, operators, and owners will find useful.

  9. Iterative guided image fusion

    Directory of Open Access Journals (Sweden)

    Alexander Toet

    2016-08-01

    Full Text Available We propose a multi-scale image fusion scheme based on guided filtering. Guided filtering can effectively reduce noise while preserving detail boundaries. When applied in an iterative mode, guided filtering selectively eliminates small scale details while restoring larger scale edges. The proposed multi-scale image fusion scheme achieves spatial consistency by using guided filtering both at the decomposition and at the recombination stage of the multi-scale fusion process. First, size-selective iterative guided filtering is applied to decompose the source images into approximation and residual layers at multiple spatial scales. Then, frequency-tuned filtering is used to compute saliency maps at successive spatial scales. Next, at each spatial scale binary weighting maps are obtained as the pixelwise maximum of corresponding source saliency maps. Guided filtering of the binary weighting maps with their corresponding source images as guidance images serves to reduce noise and to restore spatial consistency. The final fused image is obtained as the weighted recombination of the individual residual layers and the mean of the approximation layers at the coarsest spatial scale. Application to multiband visual (intensified and thermal infrared imagery demonstrates that the proposed method obtains state-of-the-art performance for the fusion of multispectral nightvision images. The method has a simple implementation and is computationally efficient.

  10. Precision mechatronics based on high-precision measuring and positioning systems and machines

    Science.gov (United States)

    Jäger, Gerd; Manske, Eberhard; Hausotte, Tino; Mastylo, Rostyslav; Dorozhovets, Natalja; Hofmann, Norbert

    2007-06-01

    Precision mechatronics is defined in the paper as the science and engineering of a new generation of high precision systems and machines. Nanomeasuring and nanopositioning engineering represents important fields of precision mechatronics. The nanometrology is described as the today's limit of the precision engineering. The problem, how to design nanopositioning machines with uncertainties as small as possible will be discussed. The integration of several optical and tactile nanoprobes makes the 3D-nanopositioning machine suitable for various tasks, such as long range scanning probe microscopy, mask and wafer inspection, nanotribology, nanoindentation, free form surface measurement as well as measurement of microoptics, precision molds, microgears, ring gauges and small holes.

  11. VOCABULARY GUIDE OF COGNATE WORDS IN SPANISH AND ENGLISH.

    Science.gov (United States)

    KRIPPNER, STANLEY

    A VOCABULARY GUIDE OF COGNATE WORDS IN ENGLISH AND SPANISH IS PRESENTED. THE VALUE OF THE GUIDE RESTS ON THE ASSUMPTIONS THAT THE LEARNING OF SIMILAR WORDS IN BOTH LANGUAGES COULD CHANGE SPANISH-SPEAKING AMERICAN PUPILS' NEGATIVE ATTITUDE ABOUT ENGLISH AS WELL AS INCREASE THEIR VOCABULARY. WORDS IN THE "VELAZQUEZ SPANISH AND ENGLISH DICTIONARY" OF…

  12. DEVELOPMENT OF VISUALLY GUIDED BEHAVIOR REQUIRES ORIENTED CONTOURS

    NARCIS (Netherlands)

    BRENNER, E; CORNELISSEN, FW

    1992-01-01

    Kittens do not learn to use visual information to guide their behaviour if they are deprived of the optic flow that accompanies their own movements. We show that the optic flow that is required for developing visually guided behaviour is derived from changes in contour orientations, rather than from

  13. Development of In-pile Plug Assembly and Primary Shutter for Cold Neutron Guide System

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jin Won; Cho, Yeong Garp; Ryu, Jeong Soo; Lee, Jung Hee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-12-15

    The HANARO, a 30 MW multi-purpose research reactor in Korea, will be equipped with a neutron guide system, in order to transport cold neutrons from the neutron source to the neutron scattering instruments in the neutron guide hall near the reactor building. The neutron guide system of HANARO consists of the in-pile plug assembly with in-pile guides, the primary shutter with in-shutter guides, the neutron guides in the guide shielding room with dedicated secondary shutters, and the neutron guides connected to the instruments in the neutron guide hall. The functions of the in-pile plug assembly are to shield the reactor environment from a nuclear radiation and to support the neutron guides and maintain them precisely oriented. The primary shutter is a mechanical device to be installed just after the in-pile plug assembly, which stops neutron flux on demand. This report describes the mechanical design, fabrication, and installation procedure of the in-pile plug assembly and the primary shutter for the neutron guide system at HANARO. A special tool and procedure for a replacement of in-pile plug and guide cassette is also presented with the interface condition in the reactor hall.

  14. Ultrasound- and MRI-Guided Prostate Biopsy

    Science.gov (United States)

    ... Resources Professions Site Index A-Z Ultrasound- and MRI-Guided Prostate Biopsy Ultrasound- and MRI-guided prostate ... MRI-guided Prostate Biopsy? What is Ultrasound- and MRI-guided Prostate Biopsy? Ultrasound- and MRI-guided prostate ...

  15. 1997~2016年国际蹦床规则变化规律性导向特征研究%The study of the international trampoline rules change regularity guide features in 1997~2016

    Institute of Scientific and Technical Information of China (English)

    何茂贵; 韩华; 徐刚

    2015-01-01

    采用文献资料、专家访谈、分析归纳、数理统计法等方法,对1997~2016年五个奥运周期国际蹦床评分规则的变化规律性导向特征进行了分析与研究,结果发现:把握高、难、准、美蹦床运动发展的总方向,突出项目特点而不断引导运动员掌握不同类型的多种动作,坚持敦促运动员努力提高成套动作的完成难度和质量,持续鼓励运动员进行创新并顺应蹦床运动技术的时代发展而不断完善评分规则,使其不断地对蹦床运动的发展起到积极的促进、规范和导向作用,是主导当今世界蹦床评分规则修订变化的主要规律性特征;未来大赛第一套动作的发展将与第二套动作趋同,而相关的系列要求与新规定,还将会为迎合其方向的发展内容而修订。%By using the methods of literature,expert interviews,analysis induction and mathematical analysis,this paper studies the oriented features for the regularity of changes of international trampoline grading rules in the five Olympic periods during 1997 to 2016. The results show that grasping the general direction of high,difficult,quasi and beautiful for the trampoline development,in order to highlight the project features and continuing to guide the athletes to grasp various actions of different types, adhering to urge athletes trying to enhance the difficulty and quality to finish complete set movement,continuing to encourage athletes to innovation and adapting to the era development of trampoline technology and continuous improvement of score rules in order to make it play a positive,standards and guidance role for the development of trampoline sports.

  16. Modernising the CERN Admin e-guide

    CERN Multimedia

    DG-RPC-PA (section des processus administratifs)

    2014-01-01

    In just a few years, the CERN Admin e-guide has become the essential guide for CERN's administrative procedures, intended not just for administrative services but for all members of the personnel of CERN. The guide is edited by the Administrative Process Section (DG-RPC-PA) and allows users to look up administrative procedures and forms relating to the application of the Staff Rules and Regulations easily in both French and English. Site visit statistics show that 5000 people on average consult the Admin e-guide each month. The most consulted procedures are those relating to green licence plates, taxes, Swiss and French cards and leave. The site has just been moved over to Drupal, which will make it easier to update the information provided and will improve content management. This system change meant migrating 220 procedures and more than 500 frequently asked questions. The structure has been revised for clarity, but the principles that made the guide so successful have not changed, namely the e...

  17. Courseware Review: Vernier Software: Precision Timer II.

    Science.gov (United States)

    Park, John C.

    1988-01-01

    Reviews "Vernier Software: Precision Timer II" for high school through college mechanics. Introduces 14 different modes including pulse time, pendulum timer, bouncer timer, gate timer, collision timers, and stroke calibration. Provides two typical displays and ratings of the software. (YP)

  18. Precise subtyping for synchronous multiparty sessions

    Directory of Open Access Journals (Sweden)

    Mariangiola Dezani-Ciancaglini

    2016-02-01

    Full Text Available The notion of subtyping has gained an important role both in theoretical and applicative domains: in lambda and concurrent calculi as well as in programming languages. The soundness and the completeness, together referred to as the preciseness of subtyping, can be considered from two different points of view: operational and denotational. The former preciseness has been recently developed with respect to type safety, i.e. the safe replacement of a term of a smaller type when a term of a bigger type is expected. The latter preciseness is based on the denotation of a type which is a mathematical object that describes the meaning of the type in accordance with the denotations of other expressions from the language. The result of this paper is the operational and denotational preciseness of the subtyping for a synchronous multiparty session calculus. The novelty of this paper is the introduction of characteristic global types to prove the operational completeness.

  19. Prospects for Precision Neutrino Cross Section Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Deborah A. [Fermilab

    2016-01-28

    The need for precision cross section measurements is more urgent now than ever before, given the central role neutrino oscillation measurements play in the field of particle physics. The definition of precision is something worth considering, however. In order to build the best model for an oscillation experiment, cross section measurements should span a broad range of energies, neutrino interaction channels, and target nuclei. Precision might better be defined not in the final uncertainty associated with any one measurement but rather with the breadth of measurements that are available to constrain models. Current experience shows that models are better constrained by 10 measurements across different processes and energies with 10% uncertainties than by one measurement of one process on one nucleus with a 1% uncertainty. This article describes the current status of and future prospects for the field of precision cross section measurements considering the metric of how many processes, energies, and nuclei have been studied.

  20. Precision Munition Electro-Sciences Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility allows the characterization of the electro-magnetic environment produced by a precision weapon in free flight. It can measure the radiofrequency (RF)...

  1. Family Day Care Zoning Advocacy Guide.

    Science.gov (United States)

    Stevenson, Carol; And Others

    Designed to help family day care providers and the agencies that support them reform local zoning laws that make it difficult or impossible to legally care for children in their homes, this guide outlines the process of obtaining a use permit, changing local laws, and strategizing for the passage of state legislation that preempts local laws. A…

  2. GUIDE TO CLEANER TECHNOLOGIES: ORGANIC COATING REPLACEMENTS

    Science.gov (United States)

    This guide describes available and emerging cleaner technologies that can be used to reduce emissions and wastes from paint and coatings applications. Environmental concerns and increasing costs of organic chemicals and metals are leading to changes in the formulation of organic ...

  3. Social Marketing. A Guide. First Draft.

    Science.gov (United States)

    Rosenau, Fred S.

    This introductory guide to nonprofit social marketing provides marketing techniques and guidelines in seven chapters. Topics covered include a general discussion of social marketing, with several definitions; market research, including factors to be considered in planning a marketing strategy, forces for and against educational changes, cluster…

  4. A path to precision in the ICU.

    Science.gov (United States)

    Maslove, David M; Lamontagne, Francois; Marshall, John C; Heyland, Daren K

    2017-04-03

    Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justifications for the adoption of a precision approach to research and practice. Inherently protean diseases states such as sepsis and acute respiratory distress syndrome have manifestations that are physiologically and anatomically diffuse, and that fluctuate over short periods of time. This leads to considerable heterogeneity among patients, and conditions in which a "one size fits all" approach to therapy can lead to widely divergent results. Current ICU therapy can thus be seen as imprecise, with the potential to realize substantial gains from the adoption of precision medicine approaches. A number of challenges still face the development and adoption of precision critical care, a transition that may occur incrementally rather than wholesale. This article describes a few concrete approaches to addressing these challenges.First, novel clinical trial designs, including registry randomized controlled trials and platform trials, suggest ways in which conventional trials can be adapted to better accommodate the physiologic heterogeneity of critical illness. Second, beyond the "omics" technologies already synonymous with precision medicine, the data-rich environment of the ICU can generate complex physiologic signatures that could fuel precision-minded research and practice. Third, the role of computing infrastructure and modern informatics methods will be central to the pursuit of precision medicine in the ICU, necessitating close collaboration with data scientists. As work toward precision critical care continues, small proof-of-concept studies may prove useful in highlighting the potential of this approach.

  5. Electroweak Precision Data and New Gauge Bosons

    CERN Document Server

    Erler, Jens

    2009-01-01

    I review constraints on the Standard Model (SM) Higgs boson from high energy electroweak (EW) precision data. The same data set also strongly limits various mixing effects of hypothetical extra neutral gauge bosons (Z') with the ordinary Z. I also discuss low energy precision measurements which are sensitive to other aspects of Z' physics, such as the direct exchange amplitude and the flavor or CP violating sectors.

  6. Precision Medicine, Diabetes, and the U.S. Food and Drug Administration.

    Science.gov (United States)

    Meyer, Robert J

    2016-11-01

    The U.S. Food and Drug Administration (FDA) has long sought to achieve the broader use of personalized medicine, which is better targeting of FDA-approved therapies through incorporating precise knowledge of a patient's underlying condition to therapies optimally chosen to match those needs. While some strides have been made in precision medicine-particularly in oncology and rare genetic diseases-most of the standard general medicine indications have yet to realize the benefits of precision-guided therapies. This includes those for diabetes mellitus (DM), both type 1 and type 2. Although the scientific and regulatory considerations needed to move to a more "precise" future of DM prevention and treatment differ between the two disease subsets, scientific advances in both must occur before the FDA can incorporate precision medicine into its oversight of DM drug development and approval. This article provides an overview of the regulatory expectations and challenges in realizing a future where the therapeutics for DM are informed by precise knowledge of a patient's genetics and specific phenotype.

  7. Precision validation of MIPAS-Envisat products

    Directory of Open Access Journals (Sweden)

    C. Piccolo

    2007-01-01

    Full Text Available This paper discusses the variation and validation of the precision, or estimated random error, associated with the ESA Level 2 products from the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS. This quantity represents the propagation of the radiometric noise from the spectra through the retrieval process into the Level 2 profile values. The noise itself varies with time, steadily rising between ice decontamination events, but the Level 2 precision has a greater variation due to the atmospheric temperature which controls the total radiance received. Hence, for all species, the precision varies latitudinally/seasonally with temperature, with a small superimposed temporal structure determined by the degree of ice contamination on the detectors. The precision validation involves comparing two MIPAS retrievals at the intersections of ascending/descending orbits. For 5 days per month of full resolution MIPAS operation, the standard deviation of the matching profile pairs is computed and compared with the precision given in the MIPAS Level 2 data, except for NO2 since it has a large diurnal variation between ascending/descending intersections. Even taking into account the propagation of the pressure-temperature retrieval errors into the VMR retrieval, the standard deviation of the matching pairs is usually a factor 1–2 larger than the precision. This is thought to be due to effects such as horizontal inhomogeneity of the atmosphere and instability of the retrieval.

  8. The Paradox of Abstraction: Precision Versus Concreteness.

    Science.gov (United States)

    Iliev, Rumen; Axelrod, Robert

    2016-11-22

    We introduce a novel measure of abstractness based on the amount of information of a concept computed from its position in a semantic taxonomy. We refer to this measure as precision. We propose two alternative ways to measure precision, one based on the path length from a concept to the root of the taxonomic tree, and another one based on the number of direct and indirect descendants. Since more information implies greater processing load, we hypothesize that nouns higher in precision will have a processing disadvantage in a lexical decision task. We contrast precision to concreteness, a common measure of abstractness based on the proportion of sensory-based information associated with a concept. Since concreteness facilitates cognitive processing, we predict that while both concreteness and precision are measures of abstractness, they will have opposite effects on performance. In two studies we found empirical support for our hypothesis. Precision and concreteness had opposite effects on latency and accuracy in a lexical decision task, and these opposite effects were observable while controlling for word length, word frequency, affective content and semantic diversity. Our results support the view that concepts organization includes amodal semantic structures which are independent of sensory information. They also suggest that we should distinguish between sensory-based and amount-of-information-based abstractness.

  9. Precision diabetes: learning from monogenic diabetes.

    Science.gov (United States)

    Hattersley, Andrew T; Patel, Kashyap A

    2017-05-01

    The precision medicine approach of tailoring treatment to the individual characteristics of each patient or subgroup has been a great success in monogenic diabetes subtypes, MODY and neonatal diabetes. This review examines what has led to the success of a precision medicine approach in monogenic diabetes (precision diabetes) and outlines possible implications for type 2 diabetes. For monogenic diabetes, the molecular genetics can define discrete aetiological subtypes that have profound implications on diabetes treatment and can predict future development of associated clinical features, allowing early preventative or supportive treatment. In contrast, type 2 diabetes has overlapping polygenic susceptibility and underlying aetiologies, making it difficult to define discrete clinical subtypes with a dramatic implication for treatment. The implementation of precision medicine in neonatal diabetes was simple and rapid as it was based on single clinical criteria (diagnosed precision diabetes approach in type 2 diabetes will require simple, quick, easily accessible stratification that is based on a combination of routine clinical data, rather than relying on newer technologies. Analysing existing clinical data from routine clinical practice and trials may provide early success for precision medicine in type 2 diabetes.

  10. Toward precision medicine in Parkinson's disease.

    Science.gov (United States)

    Bu, Lu-Lu; Yang, Ke; Xiong, Wei-Xi; Liu, Feng-Tao; Anderson, Boyd; Wang, Ye; Wang, Jian

    2016-01-01

    Precision medicine refers to an innovative approach selected for disease prevention and health promotion according to the individual characteristics of each patient. The goal of precision medicine is to formulate prevention and treatment strategies based on each individual with novel physiological and pathological insights into a certain disease. A multidimensional data-driven approach is about to upgrade "precision medicine" to a higher level of greater individualization in healthcare, a shift towards the treatment of individual patients rather than treating a certain disease including Parkinson's disease (PD). As one of the most common neurodegenerative diseases, PD is a lifelong chronic disease with clinical and pathophysiologic complexity, currently it is treatable but neither preventable nor curable. At its advanced stage, PD is associated with devastating chronic complications including both motor dysfunction and non-motor symptoms which impose an immense burden on the life quality of patients. Advances in computational approaches provide opportunity to establish the patient's personalized disease data at the multidimensional levels, which finally meeting the need for the current concept of precision medicine via achieving the minimal side effects and maximal benefits individually. Hence, in this review, we focus on highlighting the perspectives of precision medicine in PD based on multi-dimensional information about OMICS, molecular imaging, deep brain stimulation (DBS) and wearable sensors. Precision medicine in PD is expected to integrate the best evidence-based knowledge to individualize optimal management in future health care for those with PD.

  11. Platform Precision Autopilot Overview and Mission Performance

    Science.gov (United States)

    Strovers, Brian K.; Lee, James A.

    2009-01-01

    The Platform Precision Autopilot is an instrument landing system-interfaced autopilot system, developed to enable an aircraft to repeatedly fly nearly the same trajectory hours, days, or weeks later. The Platform Precision Autopilot uses a novel design to interface with a NASA Gulfstream III jet by imitating the output of an instrument landing system approach. This technique minimizes, as much as possible, modifications to the baseline Gulfstream III jet and retains the safety features of the aircraft autopilot. The Platform Precision Autopilot requirement is to fly within a 5-m (16.4-ft) radius tube for distances to 200 km (108 nmi) in the presence of light turbulence for at least 90 percent of the time. This capability allows precise repeat-pass interferometry for the Unmanned Aerial Vehicle Synthetic Aperture Radar program, whose primary objective is to develop a miniaturized, polarimetric, L-band synthetic aperture radar. Precise navigation is achieved using an accurate differential global positioning system developed by the Jet Propulsion Laboratory. Flight-testing has demonstrated the ability of the Platform Precision Autopilot to control the aircraft within the specified tolerance greater than 90 percent of the time in the presence of aircraft system noise and nonlinearities, constant pilot throttle adjustments, and light turbulence.

  12. Comparison of the precision of three commonly used GPS models

    Directory of Open Access Journals (Sweden)

    E Chavoshi

    2016-04-01

    Full Text Available Introduction: Development of science in various fields has caused change in the methods to determine geographical location. Precision farming involves new technology that provides the opportunity for farmers to change in factors such as nutrients, soil moisture available to plants, soil physical and chemical characteristics and other factors with the spatial resolution of less than a centimeter to several meters to monitor and evaluate. GPS receivers based on precision farming operations specified accuracies are used in the following areas: 1 monitoring of crop and soil sampling (less than one meter accuracy 2 use of fertilizer, pesticide and seed work (less than half a meter accuracy 3 Transplantation and row cultivation (precision of less than 4 cm (Perez et al., 2011. In one application of GPS in agriculture, route guidance precision farming tractors in the fields was designed to reduce the transmission error that deviate from the path specified in the range of 50 to 300 mm driver informed and improved way to display (Perez et al., 2011. In another study, the system automatically guidance, based on RTK-GPS technology, precision tillage operations was used between and within the rows very close to the drip irrigation pipe and without damage to their crops at a distance of 50 mm (Abidine et al., 2004. In another study, to compare the accuracy and precision of the receivers, 5 different models of Trimble Mark GPS devices from 15 stations were mapped, the results indicated that minimum error was related to Geo XT model with an accuracy of 91 cm and maximum error was related to Pharos model with an accuracy of 5.62 m (Kindra et al., 2006. Due to the increasing use of GPS receivers in agriculture as well as the lack of trust on the real accuracy and precision of receivers, this study aimed to compare the positioning accuracy and precision of three commonly used GPS receivers models used to specify receivers with the lowest error for precision

  13. Planning, Development, and Change in Bristol Bay: A High School Curriculum. Teacher Guide and Student Text. Unit V: Oil and Gas Development. Unit VI: Minerals and Mining. Unit VII: State Land Disposal. Revised

    Science.gov (United States)

    Lipka, Jerry; Willer, Cristy

    Written with the broad goal of involving high school students in Bristol Bay, Alaska, in the planning and design of their region's future, this combined teacher guide and student text contains the final three units of a seven-unit curriculum. Unit V looks at oil development in the Bering Sea, covering topics such as Alaska's dependence on oil,…

  14. Proposed design for high precision refractive index sensor using integrated planar lightwave circuit

    Science.gov (United States)

    Maru, Koichi; Fujii, Yusaku; Zhang, Shulian; Hou, Wenmei

    2009-07-01

    A high precision and compact refractive index sensor is proposed. The combination of coarse measurement utilizing the change of the angle of refraction and fine measurement utilizing the phase change is newly proposed to measure absolute refractive index precisely. The proposed method does not need expensive optical measurement equipment such as an optical spectrum analyzer. The integrated planar lightwave circuit (PLC) technology enables us to obtain a compact sensor that is preferable for the practical use. The principle, design, and some configurations for precise refractive index measurement are described.

  15. Application of precise altimetry to the study of precise leveling of the sea surface, the Earth's gravity field, and the rotation of the Earth

    Science.gov (United States)

    Segawa, J.; Ganeko, Y.; Sasaki, M.; Mori, T.; Ooe, M.; Nakagawa, I.; Ishii, H.; Hagiwara, Y.

    1991-01-01

    Our program includes five research items: (1) determination of a precision geoid and gravity anomaly field; (2) precise leveling and detection of tidal changes of the sea surface and study of the role of the tide in the global energy exchange; (3) oceanic effect on the Earth's rotation and polar motion; (4) geological and geophysical interpretation of the altimetry gravity field; and (5) evaluation of the effectiveness of local tracking of TOPEX/POSEIDON by use of a laser tracker.

  16. Ultrasound-guided interventions of the foot and ankle.

    Science.gov (United States)

    Yablon, Corrie M

    2013-02-01

    Ultrasound (US) provides excellent delineation of tendons and ligaments in the foot and ankle and provides real-time visualization of a needle during interventions, yielding greater accuracy and efficacy than the traditional blind approach using anatomical landmarks. For this reason, US is rapidly gaining acceptance as the preferred modality for guiding interventions in the foot and ankle where the anatomy is complex, neurovascular structures should be identified, and precise technique is demanded. In the foot and ankle, US is especially useful to guide tendon sheath, bursal, and Achilles paratenon injections, Morton neuroma injections, plantar fascial injections, and joint aspirations and injections.

  17. Cytoplasmic dynein binding, run length, and velocity are guided by long-range electrostatic interactions.

    Science.gov (United States)

    Li, Lin; Alper, Joshua; Alexov, Emil

    2016-08-17

    Dyneins are important molecular motors involved in many essential biological processes, including cargo transport along microtubules, mitosis, and in cilia. Dynein motility involves the coupling of microtubule binding and unbinding to a change in the configuration of the linker domain induced by ATP hydrolysis, which occur some 25 nm apart. This leaves the accuracy of dynein stepping relatively inaccurate and susceptible to thermal noise. Using multi-scale modeling with a computational focusing technique, we demonstrate that the microtubule forms an electrostatic funnel that guides the dynein's microtubule binding domain (MTBD) as it finally docks to the precise, keyed binding location on the microtubule. Furthermore, we demonstrate that electrostatic component of the MTBD's binding free energy is linearly correlated with the velocity and run length of dynein, and we use this linearity to predict the effect of mutating each glutamic and aspartic acid located in MTBD domain to alanine. Lastly, we show that the binding of dynein to the microtubule is associated with conformational changes involving several helices, and we localize flexible hinge points within the stalk helices. Taken all together, we demonstrate that long range electrostatic interactions bring a level of precision to an otherwise noisy dynein stepping process.

  18. Precision Analysis of Three Dimension Free Curves Nanofabrication

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Three dimension free curves find wide applications in engineering. There is no problem to express them exactly mathematically, but th e reportage has not been done on the investigation of precision analysis of thre e-dimension free curves nanofabrication. Nanofabrication Precision includes the geometrical precision and the precision of driving system (below simply cal led the system precision). This paper submits the precision analysis method of c urve normal vector to analyze geometrical precision. ...

  19. Mac OS X Snow Leopard pocket guide

    CERN Document Server

    Seiblod, Chris

    2009-01-01

    Whether you're new to the Mac or a longtime user, this handy book is the quickest way to get up to speed on Snow Leopard. Packed with concise information in an easy-to-read format, Mac OS X Snow Leopard Pocket Guide covers what you need to know and is an ideal resource for problem-solving on the fly. This book goes right to the heart of Snow Leopard, with details on system preferences, built-in applications, and utilities. You'll also find configuration tips, keyboard shortcuts, guides for troubleshooting, lots of step-by-step instructions, and more. Learn about new features and changes s

  20. Principles and techniques for designing precision machines

    Energy Technology Data Exchange (ETDEWEB)

    Hale, L C

    1999-02-01

    This thesis is written to advance the reader's knowledge of precision-engineering principles and their application to designing machines that achieve both sufficient precision and minimum cost. It provides the concepts and tools necessary for the engineer to create new precision machine designs. Four case studies demonstrate the principles and showcase approaches and solutions to specific problems that generally have wider applications. These come from projects at the Lawrence Livermore National Laboratory in which the author participated: the Large Optics Diamond Turning Machine, Accuracy Enhancement of High- Productivity Machine Tools, the National Ignition Facility, and Extreme Ultraviolet Lithography. Although broad in scope, the topics go into sufficient depth to be useful to practicing precision engineers and often fulfill more academic ambitions. The thesis begins with a chapter that presents significant principles and fundamental knowledge from the Precision Engineering literature. Following this is a chapter that presents engineering design techniques that are general and not specific to precision machines. All subsequent chapters cover specific aspects of precision machine design. The first of these is Structural Design, guidelines and analysis techniques for achieving independently stiff machine structures. The next chapter addresses dynamic stiffness by presenting several techniques for Deterministic Damping, damping designs that can be analyzed and optimized with predictive results. Several chapters present a main thrust of the thesis, Exact-Constraint Design. A main contribution is a generalized modeling approach developed through the course of creating several unique designs. The final chapter is the primary case study of the thesis, the Conceptual Design of a Horizontal Machining Center.

  1. Accuracy and precision in the calculation of phenology metrics

    DEFF Research Database (Denmark)

    Ferreira, Ana Sofia; Visser, Andre; MacKenzie, Brian;

    2014-01-01

    Phytoplankton phenology (the timing of seasonal events) is a commonly used indicator for evaluating responses of marine ecosystems to climate change. However, phenological metrics are vulnerable to observation-(bloom amplitude, missing data, and observational noise) and analysis-related (temporal...... resolution, preprocessing technique, and phenology metric) processes. Here we consider the impact of these processes on the robustness of four phenology metrics (timing of maximum, 5% above median, maximum growth rate, and 15% of cumulative distribution). We apply a simulation-testing approach, where...... a phenology metric is first determined from a noise- and gap-free time series, and again once it has been modified. We show that precision is a greater concern than accuracy for many of these metrics, an important point that has been hereto overlooked in the literature. The variability in precision between...

  2. Development and modulation of intrinsic membrane properties control the temporal precision of auditory brain stem neurons.

    Science.gov (United States)

    Franzen, Delwen L; Gleiss, Sarah A; Berger, Christina; Kümpfbeck, Franziska S; Ammer, Julian J; Felmy, Felix

    2015-01-15

    Passive and active membrane properties determine the voltage responses of neurons. Within the auditory brain stem, refinements in these intrinsic properties during late postnatal development usually generate short integration times and precise action-potential generation. This developmentally acquired temporal precision is crucial for auditory signal processing. How the interactions of these intrinsic properties develop in concert to enable auditory neurons to transfer information with high temporal precision has not yet been elucidated in detail. Here, we show how the developmental interaction of intrinsic membrane parameters generates high firing precision. We performed in vitro recordings from neurons of postnatal days 9-28 in the ventral nucleus of the lateral lemniscus of Mongolian gerbils, an auditory brain stem structure that converts excitatory to inhibitory information with high temporal precision. During this developmental period, the input resistance and capacitance decrease, and action potentials acquire faster kinetics and enhanced precision. Depending on the stimulation time course, the input resistance and capacitance contribute differentially to action-potential thresholds. The decrease in input resistance, however, is sufficient to explain the enhanced action-potential precision. Alterations in passive membrane properties also interact with a developmental change in potassium currents to generate the emergence of the mature firing pattern, characteristic of coincidence-detector neurons. Cholinergic receptor-mediated depolarizations further modulate this intrinsic excitability profile by eliciting changes in the threshold and firing pattern, irrespective of the developmental stage. Thus our findings reveal how intrinsic membrane properties interact developmentally to promote temporally precise information processing.

  3. Precision-guided vehicle for transport and installation of LHC cryomagnets

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    LHC quadrupoles and dipoles are heavier, longer and more fragile than the magnets used in CERN s former LEP collider. Therefore, an innovative solution for their transport and installation in the tunnel has been developed. It consists of convoys of two tractors, a trailer and unloading equipment. The convoys feature infrared optical guidance, which offsets the minimal clearance inside the tunnel, and are designed to minimize vibration of the magnets during transport. Operations will be monitored by a technician, who will take over the controls to unload and install the magnets. The first such convoy is now undergoing testing in the tunnel. The people who have contributed to the new transport system are pictured here at Point 4 in the LHC tunnel where tests on the first convoy are being conducted. The optical guidance system uses the white lines on the floor (Photos 01 and 03) to steer the vehicle in the tunnel. The prototype quadrupole magnet used in the tests is visible in Photos 02 and 04.

  4. Precision Guided Munitions: Constructing a Bomb More Potent Than the A-Bomb

    Science.gov (United States)

    2002-06-01

    military advantage is hardly unique to the American experience. Technology has shaped warfare in important ways since Herodotus first historicized armed...as today, likely took for granted the then-current state of the art, without feeling compelled to historicize it. However, even a cursory review of

  5. Guidance, Control and Positioning of Future Precision Guided Stand-off Weapons Systems

    Science.gov (United States)

    1986-06-01

    ngcessairsment lieu entre deux missiles adjacents. Les missiles i et i+1 entrent en collision si l𔄀cart relatif &. passe par le domajne & entre deux recal ... airbag manufacturers. The resulting ejection concept incorporates a dual airbag system in which individual submunitions are grouped into subpacks...consisting of submunitions, an airbag and foam dunnage. These subpacks are arranged around one or more primary airbags which are used to eject the subpacks

  6. Precision Engagement at the Strategic Level of War: Guiding Promise or Wishful Thinking?

    Science.gov (United States)

    2001-04-01

    short-term predictability to achieve longer term outcomes. Alvin Saperstein, writing in American Scientist , suggested that such control might be...New Millennium Conference, Alexandria, Va., 8 February 2001. 22 Alvin M. Saperstein, —War and Chaos,“ American Scientist 83, no. 6 (November...Decade of Transformation.“ Armed Forces Journal International, March 2001, 68. Saperstein, Alvin M. —War and Chaos.“ American Scientist 83, no

  7. Rehabilitation of a dentate mandible requiring a full arch rehabilitation. Immediate loading of a fixed complete denture on 8 implants placed with a bone-supported surgical computer-planned guide: a case report.

    Science.gov (United States)

    Amorfini, Leonardo; Storelli, Stefano; Romeo, Eugenio

    2011-03-01

    The use of technologies that merge computerized tomography X-ray imaging and 3-dimensional (3D) planning software allow the surgeon to digitally elaborate on the computer the position, length, and diameter of every implant to be placed. Following this approach, the placement is guided in a 3D digital model, and the implants are placed in the final position avoiding eventual anatomic structures. In this case report, the patient's remaining mandibular teeth were extracted, and the patient received 8 implants with the help of a computer surgical guide. The case was planned using SimPlant and a bone-supported guide. Because of the high precision of the planning, it was possible to realize a provisional rehabilitation before the actual surgery. The planning allows placement of parallel implants to optimize the prosthetic procedure and outcome. An immediate provisional implant was fixed with a flow composite on the temporary abutments and then refined in the dental laboratory. The patient received the provisional rehabilitation the same day of the surgery. After 6 weeks of healing, the final impression was taken and the prosthesis was finalized with a computer-aided design/computer-aided manufacturing titanium full-arch screwed framework with composite veneering. A 6-month follow-up showed good integration of the prostheses and success of all 8 implants. The use of surgical computer-guided planning changes the surgeon's approach: whereas before the use of conventional guides permitted a certain degree of offset from what was planned, the use of computer guides allows the implant to be inserted in a far more precise way. It is obvious that careful planning is the key factor to avoid implant misplacement.

  8. Google Pocket Guide

    CERN Document Server

    Calishain, Tara; Adams, DJ

    2003-01-01

    Beneath its deceptively simple search form, Google is a remarkably powerful and flexible search engine that indexes billions of web pages, handling more than 150 million searches a day. You know that what you're looking for must be in there somewhere, but how do you make Google work for you? Crafted from our best-selling Google Hacks title, the Google Pocket Guide provides exactly the information you need to make your searches faster and more effective, right from the start. The Google Pocket Guide unleashes the power behind that blinking cursor by delivering: A thorough but concise tour o

  9. Cassandra the definitive guide

    CERN Document Server

    Hewitt, Eben

    2011-01-01

    What could you do with data if scalability wasn't a problem? With this hands-on guide, you'll learn how Apache Cassandra handles hundreds of terabytes of data while remaining highly available across multiple data centers -- capabilities that have attracted Facebook, Twitter, and other data-intensive companies. Cassandra: The Definitive Guide provides the technical details and practical examples you need to assess this database management system and put it to work in a production environment. Author Eben Hewitt demonstrates the advantages of Cassandra's nonrelational design, and pays special

  10. Seismic Safety Guide

    Energy Technology Data Exchange (ETDEWEB)

    Eagling, D.G. (ed.)

    1983-09-01

    This guide provides managers with practical guidelines for administering a comprehensive earthquake safety program. The Guide is comprehensive with respect to earthquakes in that it covers the most important aspects of natural hazards, site planning, evaluation and rehabilitation of existing buildings, design of new facilities, operational safety, emergency planning, special considerations related to shielding blocks, non-structural elements, lifelines, fire protection and emergency facilities. Management of risk and liabilities is also covered. Nuclear facilities per se are not dealt with specifically. The principles covered also apply generally to nuclear facilities but the design and construction of such structures are subject to special regulations and legal controls.

  11. Guide to software export

    CERN Document Server

    Philips, Roger A

    2014-01-01

    An ideal reference source for CEOs, marketing and sales managers, sales consultants, and students of international marketing, Guide to Software Export provides a step-by-step approach to initiating or expanding international software sales. It teaches you how to examine critically your candidate product for exportability; how to find distributors, agents, and resellers abroad; how to identify the best distribution structure for export; and much, much more!Not content with providing just the guidelines for setting up, expanding, and managing your international sales channels, Guide to Software

  12. Raspberry Pi user guide

    CERN Document Server

    Halfacree, Gareth

    2012-01-01

    Make the most out of the world’s first truly compact computer It's the size of a credit card, it can be charged like a smartphone, it runs on open-source Linux, and it holds the promise of bringing programming and playing to millions at low cost. And now you can learn how to use this amazing computer from its co-creator, Eben Upton, in Raspberry Pi User Guide. Cowritten with Gareth Halfacree, this guide gets you up and running on Raspberry Pi, whether you're an educator, hacker, hobbyist, or kid. Learn how to connect your Pi to other hardware, install software, write basic programs, an

  13. 2013 Australasian sky guide

    CERN Document Server

    Lomb, Nick

    2012-01-01

    Compact, easy to use and reliable, this popular guide contains everything you need to know about the southern night sky with monthly star maps, diagrams and details of all the year's exciting celestial events. Wherever you are in Australia or New Zealand, easy calculations allow you to determine when the Sun, Moon and planets will rise and set throughout the year. Also included is information on the latest astronomical findings from space probes and telescopes around the world. The Sky guide has been published annually by the Powerhouse Museum, Sydney, since 1991. It is recommended for photogr

  14. Jenkins The Definitive Guide

    CERN Document Server

    Smart, John

    2011-01-01

    Streamline software development with Jenkins, the popular Java-based open source tool that has revolutionized the way teams think about Continuous Integration (CI). This complete guide shows you how to automate your build, integration, release, and deployment processes with Jenkins-and demonstrates how CI can save you time, money, and many headaches. Ideal for developers, software architects, and project managers, Jenkins: The Definitive Guide is both a CI tutorial and a comprehensive Jenkins reference. Through its wealth of best practices and real-world tips, you'll discover how easy it is

  15. Raspberry Pi user guide

    CERN Document Server

    Upton, Eben

    2013-01-01

    The essential guide to getting started with the Raspberry Pi ® The Raspberry Pi has been a success beyond the dream of its creators. Their goal, to encourage a new generation of computer programmers who understand how computers work, is well under way. Raspberry Pi User Guide 2e is the newest edition of the runaway bestseller written by the Pi's co-creator, Eben Upton, and tech writer Gareth Halfacree. It contains everything you need to know to get the Pi up and running, including how to: Connect a keyboard, mouse, monitor and other peripheralsInstall software and configure your Raspberry

  16. Synthetic guide star generation

    Science.gov (United States)

    Payne, Stephen A [Castro Valley, CA; Page, Ralph H [Castro Valley, CA; Ebbers, Christopher A [Livermore, CA; Beach, Raymond J [Livermore, CA

    2008-06-10

    A system for assisting in observing a celestial object and providing synthetic guide star generation. A lasing system provides radiation at a frequency at or near 938 nm and radiation at a frequency at or near 1583 nm. The lasing system includes a fiber laser operating between 880 nm and 960 nm and a fiber laser operating between 1524 nm and 1650 nm. A frequency-conversion system mixes the radiation and generates light at a frequency at or near 589 nm. A system directs the light at a frequency at or near 589 nm toward the celestial object and provides synthetic guide star generation.

  17. Outdoor lighting guide

    CERN Document Server

    2013-01-01

    As concern grows over environmental issues and light pollution, this book satisfies a need for a straightforward and accessible guide to the use, design and installation of outdoor lighting.This all-inclusive guide to exterior lighting from the Institution of Lighting Engineers, recognized as the pre-eminent professional source in the UK for authoritative guidance on exterior lighting, provides a comprehensive source of information and advice on all forms of exterior lighting, from floodlighting, buildings and road lighting to elaborate Christmas decorations. Useful to practitioners

  18. Joomla! 25 Beginner's Guide

    CERN Document Server

    Tiggeler, Eric

    2012-01-01

    Written with a fast-paced but friendly and engaging approach, this Packt Beginner's guide is designed to be placed alongside the computer as your guide and mentor. Step-by-step tutorials are bolstered by explanations of the reasoning behind what you are doing. You will quickly pick up the necessary skills, tips, and tricks for building a successful Joomla! website. This book is written for beginners to website design. By the end of the book you will have built a complete custom content managed website, and be ready to build any kind of website.

  19. The OSIRIS user guide

    CERN Document Server

    Telling, M T F

    2003-01-01

    This user guide contains all the information necessary to perform a successful neutron scattering experiment on the OSIRIS spectrometer at ISIS, RAL, UK. Since OSIRIS is a continually evolving and improving instrument some information contained within this manual may become redundant. However, the basic instrument operating procedures should remain essentially unchanged. While updated manuals will be produced when appropriate, the most comprehensive source of information concerning OSIRIS is the Instrument Scientist/Local Contact. It would be appreciated, however, if this user guide were the first point of call should problems arise

  20. CFEngine 3 Beginner's Guide

    CERN Document Server

    Rajneesh

    2011-01-01

    Part of Packt's Beginner's Guide series, this book guides you through setting up Cfengine to maximizing its potential. This book focuses on getting you through all the major learning points in a smooth, logical order. You'll also learn how to avoid some common pitfalls. If you are a System Administrator or Configuration manager with a growing infrastructure and if you are looking for a dependable tool to manage your infrastructure, then this book is for you. If your infrastructure is already big with hundreds and thousands of nodes and you are looking for a secure, versatile and stable configu

  1. Adobe Edge Quickstart Guide

    CERN Document Server

    Labrecque, Joseph

    2012-01-01

    Adobe Edge Quickstart Guide is a practical guide on creating engaging content for the Web with Adobe's newest HTML5 tool. By taking a chapter-by-chapter look at each major aspect of Adobe Edge, the book lets you digest the available features in small, easily understandable chunks, allowing you to start using Adobe Edge for your web design needs immediately. If you are interested in creating engaging motion and interactive compositions using web standards with professional tooling, then this book is for you. Those with a background in Flash Professional wanting to get started quickly with Adobe

  2. Toward Precision Healthcare: Context and Mathematical Challenges

    Science.gov (United States)

    Colijn, Caroline; Jones, Nick; Johnston, Iain G.; Yaliraki, Sophia; Barahona, Mauricio

    2017-01-01

    Precision medicine refers to the idea of delivering the right treatment to the right patient at the right time, usually with a focus on a data-centered approach to this task. In this perspective piece, we use the term “precision healthcare” to describe the development of precision approaches that bridge from the individual to the population, taking advantage of individual-level data, but also taking the social context into account. These problems give rise to a broad spectrum of technical, scientific, policy, ethical and social challenges, and new mathematical techniques will be required to meet them. To ensure that the science underpinning “precision” is robust, interpretable and well-suited to meet the policy, ethical and social questions that such approaches raise, the mathematical methods for data analysis should be transparent, robust, and able to adapt to errors and uncertainties. In particular, precision methodologies should capture the complexity of data, yet produce tractable descriptions at the relevant resolution while preserving intelligibility and traceability, so that they can be used by practitioners to aid decision-making. Through several case studies in this domain of precision healthcare, we argue that this vision requires the development of new mathematical frameworks, both in modeling and in data analysis and interpretation.

  3. Research on tracking precision of the heliostat

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Wenfeng [Himin Solar Energy Group Co., Ltd, Dezhou (China); CAS, Beijing (China). Inst. of Electrical Engineering; Wang, Zhifeng [CAS, Beijing (China). Inst. of Electrical Engineering

    2008-07-01

    The tracking precision and manufacture cost of the heliostats is obviously crucial to the system efficiency and its investment scale in a tower power plant. An open loop control system according to astronomic formula of high precision was proposed in this paper. The astronomical formulae to calculate the solar zenith and azimuth angles with uncertainties of {+-}0.005 mrad (milli-radian). This System was built in 2005 at De Zhou China. The structure of this control system is 'PC-PLC-PLC'. Taking account of the inevitable error occurred during the heliostat's installation, a mathematic model was established in this paper. The tracking control precision of this system is 0.17 mrad. Total error stack-ups for tracking and beam quality in calm winds is about 3 mrad. Drive systems with large gear ratios were designed to give sufficiently rapid movement in high wind condition with sufficient precision to meet the focusing requirement which minimizing motor power and manufacturing costs. After the analysis on the gear down ratio of the drive system in a heliostat unit, it came to the conclusion that having one inverter connected to two common motors with time-sharing control can not only meet the tracking precision requirement but achieve low cost. (orig.)

  4. Stability precision dynamic testing system on artillery

    Science.gov (United States)

    Wang, Chunyan; Li, Bo

    2014-12-01

    Dynamic feature of Weapon equipments is one of important performance index for evaluating the performance of the whole weapon system. The construction of target range in our country in fire control dynamic testing is relatively backward; therefore, it has greatly influenced the evaluation on the fire control system. In order to solve this problem, it's urgent to develop a new testing instrument so as to adjust to the armament research process and promote weapon system working more efficiently and thereby meeting the needs of modernization in national defense. This paper proposes a new measure which is used to test the stability precision of the fire control system, and it is installed on the moving base. Using the method, we develop a testing system which can test the stability precision of the fire control system and achieve a high precision results after testing. The innovation of the system is we can receive the image not only by CCD, but our eyes. It also adopts digital image-forming and image processing technique for real-time measurement and storing of the target information; it simultaneously adopts the method adjusting the platform and the corresponding fixture mounted on a sample to measure the stable precision and the precision of corner of stabilizator. In this paper, we make a description on the construction of the system and the idea of the designing of the optical system. Finally, we introduce the actual application of the system and testing results.

  5. Apparatus for precision micromachining with lasers

    Science.gov (United States)

    Chang, J.J.; Dragon, E.P.; Warner, B.E.

    1998-04-28

    A new material processing apparatus using a short-pulsed, high-repetition-rate visible laser for precision micromachining utilizes a near diffraction limited laser, a high-speed precision two-axis tilt-mirror for steering the laser beam, an optical system for either focusing or imaging the laser beam on the part, and a part holder that may consist of a cover plate and a back plate. The system is generally useful for precision drilling, cutting, milling and polishing of metals and ceramics, and has broad application in manufacturing precision components. Precision machining has been demonstrated through percussion drilling and trepanning using this system. With a 30 W copper vapor laser running at multi-kHz pulse repetition frequency, straight parallel holes with size varying from 500 microns to less than 25 microns and with aspect ratios up to 1:40 have been consistently drilled with good surface finish on a variety of metals. Micromilling and microdrilling on ceramics using a 250 W copper vapor laser have also been demonstrated with good results. Materialographic sections of machined parts show little (submicron scale) recast layer and heat affected zone. 1 fig.

  6. Transportation and packaging resource guide

    Energy Technology Data Exchange (ETDEWEB)

    Arendt, J.W.; Gove, R.M.; Welch, M.J.

    1994-12-01

    The purpose of this resource guide is to provide a convenient reference document of information that may be useful to the U.S. Department of Energy (DOE) and DOE contractor personnel involved in packaging and transportation activities. An attempt has been made to present the terminology of DOE community usage as it currently exists. DOE`s mission is changing with emphasis on environmental cleanup. The terminology or nomenclature that has resulted from this expanded mission is included for the packaging and transportation user for reference purposes. Older terms still in use during the transition have been maintained. The Packaging and Transportation Resource Guide consists of four sections: Sect. 1, Introduction; Sect. 2, Abbreviations and Acronyms; Sect. 3, Definitions; and Sect. 4, References for packaging and transportation of hazardous materials and related activities, and Appendices A and B. Information has been collected from DOE Orders and DOE documents; U.S Department of Transportation (DOT), U.S. Environmental Protection Agency (EPA), and U.S. Nuclear Regulatory Commission (NRC) regulations; and International Atomic Energy Agency (IAEA) standards and other international documents. The definitions included in this guide may not always be a regulatory definition but are the more common DOE usage. In addition, the definitions vary among regulatory agencies. It is, therefore, suggested that if a definition is to be used in a regulatory or a legal compliance issue, the definition should be verified with the appropriate regulation. To assist in locating definitions in the regulations, a listing of all definition sections in the regulations are included in Appendix B. In many instances, the appropriate regulatory reference is indicated in the right-hand margin.

  7. Sensors Based on Spectroscopy of Guided Waves

    Science.gov (United States)

    Homola, Jiří

    The last two decades have witnessed remarkable progress in the develpment of affinity biosensors and their applications in areas such as environmental protection, biotechnology, medical diagnostics, drug screening, food safety, and security. An affinity biosensor consists of a transducer and a biological recognition element which is able to interact with a selected analyte. Various optical methods have been exploited in biosensors including fluorescence spectroscopy, interferometry (reflectometric white light interferometry, modal interferometry in optical waveguide structures), and spectroscopy of guided modes of optical waveguides. Optical biosensors based on spectroscopy of guided modes of optical waveguides - grating coupler, resonant mirror, and surface plasmon resonance (SPR) - rely on the measurement of binding-induced refractive index changes and thus are label-free technologies. This paper reviews fundamentals of optical sensors based on spectroscopy of guided modes of optical waveguides and their applications.

  8. The guided autobiography method: a learning experience.

    Science.gov (United States)

    Thornton, James E

    2008-01-01

    This article discusses the proposition that learning is an unexplored feature of the guided autobiography method and its developmental exchange. Learning, conceptualized and explored as the embedded and embodied processes, is essential in narrative activities of the guided autobiography method leading to psychosocial development and growth in dynamic, temporary social groups. The article is organized in four sections and summary. The first section provides a brief overview of the guided autobiography method describing the interplay of learning and experiencing in temporary social groups. The second section offers a limited review on learning and experiencing as processes that are essential for development, growth, and change. The third section reviews the small group activities and the emergence of the "developmental exchange" in the guided autobiography method. Two theoretical constructs provide a conceptual foundation for the developmental exchange: a counterpart theory of aging as development and collaborative-situated group learning theory. The summary recaps the main ideas and issues that shape the guided autobiography method as learning and social experience using the theme, "Where to go from here."

  9. High-Precision Computation and Mathematical Physics

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2008-11-03

    At the present time, IEEE 64-bit floating-point arithmetic is sufficiently accurate for most scientific applications. However, for a rapidly growing body of important scientific computing applications, a higher level of numeric precision is required. Such calculations are facilitated by high-precision software packages that include high-level language translation modules to minimize the conversion effort. This paper presents a survey of recent applications of these techniques and provides some analysis of their numerical requirements. These applications include supernova simulations, climate modeling, planetary orbit calculations, Coulomb n-body atomic systems, scattering amplitudes of quarks, gluons and bosons, nonlinear oscillator theory, Ising theory, quantum field theory and experimental mathematics. We conclude that high-precision arithmetic facilities are now an indispensable component of a modern large-scale scientific computing environment.

  10. Precision spectroscopy of trapped radium ions

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J.E. van den; Giri, G.S.; Hoek, D.J. van der; Hoekman, S.M.; Hoekstra, S.; Jungmann, K.; Kruithof, W.L.; Nunez-Portela, M.; Onderwater, C.J.G.; Prinsen, E.B.; Sahoo, B.K.; Santra, B.; Sohani, M.; Shidling, P.D.; Timmermans, R.G.E.; Versolato, O.O.; Wansbeek, L.W.; Willmann, L.; Wilschut, H.W. [Kernfysisch Versneller Instituut, University of Groningen (Netherlands)

    2011-07-01

    Radium ion is an ideal candidate for high precision experiments. Atomic Parity Violation (APV) can be measured in a single trapped and laser cooled Ra{sup +}, enabling a precise measurement of the electroweak mixing angle in the Standard Model of particle physics at the lowest possible momentum transfer. Ultra-narrow transitions in this system can also be exploited to realize a high stability frequency standard. As an important step towards such high precision experiments, excited-state laser spectroscopy is being performed with trapped short-lived {sup 209-214}Ra{sup +} ions. The results on hyperfine structure, isotope shift and lifetime provide benchmark for the required atomic theory. The experimental set up to perform laser cooling of the trapped radium ions and trapping of a single radium ion is under way.

  11. Precision Optics Optimization for GMp Experiment

    Science.gov (United States)

    Wang, Yang; Allada, Kalyan; Averett, Todd; Christy, Eric; Gu, Chao; Huang, Min; Wojtsekhowski, Bogdan; GMp Collaboration

    2015-04-01

    The GMp experiment aims to improve the precision on the elastic e-p cross section measurement to 2%; up to a factor of 5 better than previous measurements, with four-momentum transfer up to 14 GeV2 using the High Resolution Spectrometers (HRS) of Hall A at Jefferson Lab. These measurements will be an important benchmark for many other cross section measurements in hadron physics. To reach this goal, it is necessary to improve the precision of many instrument systems. Knowledge of the magnetic optics of HRS is critically important for precision reconstruction of the momentum and coordinates of the scattered particles at the interaction vertex. In this talk, an improved optimization method for optics will be presented in detail and the results of a study based on recent commissioning data in 2014 will be discussed.

  12. Iterative Precise Conductivity Measurement with IDEs.

    Science.gov (United States)

    Hubálek, Jaromír

    2015-05-22

    The paper presents a new approach in the field of precise electrolytic conductivity measurements with planar thin- and thick-film electrodes. This novel measuring method was developed for measurement with comb-like electrodes called interdigitated electrodes (IDEs). Correction characteristics over a wide range of specific conductivities were determined from an interface impedance characterization of the thick-film IDEs. The local maximum of the capacitive part of the interface impedance is used for corrections to get linear responses. The measuring frequency was determined at a wide range of measured conductivity. An iteration mode of measurements was suggested to precisely measure the conductivity at the right frequency in order to achieve a highly accurate response. The method takes precise conductivity measurements in concentration ranges from 10(-6) to 1 M without electrode cell replacement.

  13. Large precision muon detector for ATLAS

    CERN Document Server

    Zhou Bing

    2002-01-01

    The ATLAS muon spectrometer is designed to exploit the full physics discovery potential at the Large Hadron Collider in a stand-alone mode. The precision muon detector is made of monitored drift tubes with tracking precision better than 50 mum to measure the muon track sagitta in the toroidal magnetic field. A world-wide intensive construction work of the ATLAS muon detector is under way. We report the precision muon detector mass production experience, including the R&D results on the long tube operation stability and the impact on the momentum resolution due to wire sag. The quality control data in mass production are presented. Cosmic ray test results show that the MDT chambers have tracking efficiency close to 100% and single wire resolution is better than 80 mum.

  14. Large precision muon detector for ATLAS

    CERN Document Server

    Zhou Bing

    2002-01-01

    The ATLAS muon spectrometer is designed to exploit the full physics discovery potential at the Large Hadron Collider in a stand-alone mode. The precision muon detector is made of monitored drift tubes with tracking precision better than 50 mu m to measure the muon track sagitta in the toroidal magnetic field. A world-wide intensive construction work of the ATLAS muon detector is under way. We report the precision muon detector mass production experience, including the R and D results on the long tube operation stability and the impact on the momentum resolution due to wire sag. The quality control data in mass production are presented. Cosmic ray test results show that the MDT chambers have tracking efficiency close to 100% and single wire resolution is better than 80 mu m.

  15. Novel precision piezoelectric step rotary actuator

    Institute of Scientific and Technical Information of China (English)

    LIU Jianfang; YANG Zhigang; ZHAO Hongwei; CHENG Guangming

    2007-01-01

    A novel piezoelectric (PZT) precision step rotary actuator was developed on the basis of PZT technology.It adopts the principle of bionics and works with an inside anchoring/loosening of the stator and a distortion structure of the uniformly distributed thin flexible hinge to solve problems such as ineffective anchoring/loosening,low step rotary frequency,small travel,poor resolution,low speed and unsteady output.The developed actuator is characterized by high frequency (30 Hz),high speed (380 μrad/s),large travel (>270°),high resolution (1 μrad/step),and work stability.It greatly improves the ability to drive the existing PZT step rotary actuator.The new actuator can be applied in the field of micromanipulation and precision engineering,including precision driving and positioning and optics engineering.

  16. Des Guides Joanne au Guide Vert Michelin : points, lignes, surfaces

    Directory of Open Access Journals (Sweden)

    Marie-Vic Ozouf-Marignier

    2011-06-01

    Full Text Available Cet article étudie la perception de l’espace dans les guides touristiques de la fin du XIXe siècle à nos jours. Il compare trois collections de guides français : les Guides Joanne, les Guides Bleus Hachette et les Guides Verts Michelin. Nous avons identifié trois moments majeurs. Dans une première période, le voyage en chemin de fer détermine une représentation linéaire de l’espace agrémentée de quelques coups d’œil à l’intérieur du paysage à l’endroit des stations. Dans une seconde période, le déplacement en voiture permet à une appréhension régionale de se développer. L’école française de géographie influence alors l’écriture des introductions de guide. Les rédacteurs introduisent de plus en plus de cartes dans ces ouvrages. L’unité régionale devient sensible, notamment du point de vue naturaliste. Toutefois, la recherche des curiosités, musées églises, châteaux et ruines se maintient également. De nos jours, l’autoroute, le train à grande vitesse et l’industrie touristique ont changé les pratiques et représentations de l’espace. Les touristes semblent apprécier le fait de collectionner les sites de visite et de faire des circuits à thème.This article deals with tourist perception of the space from the end of the nineteenth century to our days. It compares three collections of French tourist guides: Guides Joanne, blue guides Hachette and Guides Verts Michelin. Three main periods can be distinguished. First, railway travel determines linear representation of the landscape, with a few glances on the countryside at the stations. In a second period, the car mobility makes possible a surrounding vision of regions. French school of geography influences the prefaces of the guides. Editors introduce more and more maps inside the guides. Regional cohesion becomes perceptible, especially from a naturalistic point of view. Interesting sights, museums, churches, castles and ruins remain

  17. PRECISION ELECTROWEAK MEASUREMENTS AND THE HIGGS MASS.

    Energy Technology Data Exchange (ETDEWEB)

    MARCIANO, W.J.

    2004-08-02

    The utility of precision electroweak measurements for predicting the Standard Model Higgs mass via quantum loop effects is discussed. Current constraints from m{sub w} and sin{sup 2} {theta}{sub w} (m{sub z}){sub {ovr MS}} imply a relatively light Higgs {approx}< 154 GeV which is consistent with Supersymmetry expectations. The existence of Supersymmetry is further suggested by a discrepancy between experiment and theory for the muon anomalous magnetic moment. Constraints from precision studies on other types of ''New Physics'' are also briefly described.

  18. High-speed precision motion control

    CERN Document Server

    Yamaguchi, Takashi; Pang, Chee Khiang

    2011-01-01

    Written for researchers and postgraduate students in Control Engineering, as well as professionals in the Hard Disk Drive industry, this book discusses high-precision and fast servo controls in Hard Disk Drives (HDDs). The editors present a number of control algorithms that enable fast seeking and high precision positioning, and propose problems from commercial products, making the book valuable to researchers in HDDs. Each chapter is self contained, and progresses from concept to technique, present application examples that can be used within automotive, aerospace, aeronautical, and manufactu

  19. High precision detector robot arm system

    Science.gov (United States)

    Shu, Deming; Chu, Yong

    2017-01-31

    A method and high precision robot arm system are provided, for example, for X-ray nanodiffraction with an X-ray nanoprobe. The robot arm system includes duo-vertical-stages and a kinematic linkage system. A two-dimensional (2D) vertical plane ultra-precision robot arm supporting an X-ray detector provides positioning and manipulating of the X-ray detector. A vertical support for the 2D vertical plane robot arm includes spaced apart rails respectively engaging a first bearing structure and a second bearing structure carried by the 2D vertical plane robot arm.

  20. Micropropulsion Systems for Precision Controlled Space Flight

    DEFF Research Database (Denmark)

    Larsen, Jack

    . This project is thus concentrating on developing a method by which an entire, ecient, control system compensating for the disturbances from the space environment and thereby enabling precision formation flight can be realized. The space environment is initially studied and the knowledge gained is used...... of the disturbance forces and their influence on a precision controlled spacecraft, is used to deduce the requirements for a micropropulsion system compensating for these. Following this an LTCC based resistojet microthruster is developed and fabricated, utilizing water as fuel. Towards the end of the project...

  1. Toward precision measurements in solar neutrinos

    CERN Document Server

    De Holanda, P C; Smirnov, A Yu; Liao, Wei

    2004-01-01

    Solar neutrino physics enters the stage of precision measurements. In this connection we present the precise analytic description of the neutrino conversion in the context of the LMA MSW solution of the solar neutrino problem. Using the adiabatic perturbation theory we find an analytic formula for the survival probability which takes into account the non-adiabatic corrections and the regeneration effect inside the Earth. The probability is averaged over the neutrino production region. We find that the non-adiabatic corrections are of the order $10^{-9}-10^{-7}$. Using the formula for the Earth regeneration effect we discuss features of the zenith angle dependence of the $\

  2. Precision measurement of oscillation parameters with reactors

    OpenAIRE

    2003-01-01

    We review the potential of long and intermediate baseline reactor neutrino experiments in measuring the mass and mixing parameters. The KamLAND experiment can measure the solar mass squared difference very precisely. However it is not at the ideal baseline for measuring the solar neutrino mixing angle. If low-LMA is confirmed by the next results from KamLAND, a reactor experiment with a baseline of 70 km should be ideal to measure precisely the solar neutrino mixing angle. If on the contrary ...

  3. Electroweak precision data and gravitino dark matter

    Indian Academy of Sciences (India)

    S Heinemeyer

    2007-11-01

    Electroweak precision measurements can provide indirect information about the possible scale of supersymmetry already at the present level of accuracy. We review present day sensitivities of precision data in mSUGRA-type models with the gravitino as the lightest supersymmetric particle (LSP). The 2 fit is based on , sin2 eff, ( - 2) BR( → ) and the lightest MSSM Higgs boson mass, ℎ. We find indications for relatively light soft supersymmetry-breaking masses, offering good prospects for the LHC and the ILC, and in some cases also for the Tevatron.

  4. Precision medicine: what's all the fuss about?

    Science.gov (United States)

    Barker, Richard

    2016-01-01

    Precision medicine is now recognized globally as a major new era in medicine. It is being driven by advances in genomics and other 'omics' but also by the desire on the part of both health systems and governments to offer more targeted and cost-effective care. However, it faces a number of challenges, from the economics of developing more expensive companion diagnostics to the need to educate patients and the public on the advantages for them. New models of both R&D and care delivery are needed to capture the scientific, clinical and economic benefits of precision medicine.

  5. Repeated High-Precision Gravity and GPS Measurement Techniques

    Science.gov (United States)

    Gettings, P.; Harris, R. N.; Allis, R.; Chapman, D. S.

    2003-12-01

    Repeated high-precision gravity and GPS measurements are becoming a common tool for tracking changes in subsurface reservoirs. Despite this, there is little literature which discusses measurement techniques and the expected errors. Our research has focused on improving measurement techniques to be applied to ground water and geothermal steam reservoirs, including quantifying the minimum error levels with modern equipment. We applied these methods in two studies: ground water monitoring of the southern Salt Lake valley, Utah, USA, and steam monitoring of The Geysers geothermal field, California, USA. Gravity measurements using modern relative high-precision meters, such as Scintrex CG-3Ms or L&R E series, can now be routinely made to an accuracy of 5 μ Gal. Such accuracy requires the use of time series analysis at each station, and non-linear instrument drift functions. Modern computerized meters are capable of internally storing a time series of measurements for each station; older meters can often be fitted to log such data to a field computer. This time series, typically of 10-15 minute duration in our work, can then be analyzed in several ways to produce stable estimates of the gravity reading. In particular, our research has emphasized using a weighted arithmetic average (for long occupations), or a Thiele extrapolation scheme (for shorter station occupations). Instrument drift is removed through a superposition of a linear long-term drift function, and an empirical staircase function formed from differences between repeated station occupations. To achieve high-accuracy GPS measurements while maximizing the number of field stations in a survey, rapid-static measurements are necessary. We have tested the effect of occupation time and processing schemes on the absolute accuracy of the resulting GPS position. Using a post-processing differential method with a fixed (but not necessarily continuous) base station within 15 km, positioning error of <4 cm vertical is

  6. Electrical Distribution Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This program guide contains the standard electrical distribution curriculum for technical institutes in Georgia. The curriculum encompasses the minimum competencies required for entry-level workers in the electrical distribution field, and in job skills such as construction, maintenance, and repair of overhead and underground electrical…

  7. Environmental Horticulture Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This program guide contains the standard environmental horticulture curriculum for technical institutes in Georgia. The curriculum encompasses the minimum competencies required for entry-level workers in the environmental horticulture field. The general information section contains the following: purpose and objectives; program description,…

  8. Material Writer's Guide.

    Science.gov (United States)

    Byrd, Patricia, Ed.

    This guide is a collection of essays on the writing of English-as-a-Second-Language (ESL) textbooks and other instructional materials. Articles include: "Writing and Publishing Textbooks (Patricia Byrd); "The Craft of Materials Writing" (Fraida Dubin); "Considering Culture: Guidelines for ESL/EFL Textbook Writers" (Gayle Nelson); "Issues in the…

  9. Cosmetology. Secondary Curriculum Guide.

    Science.gov (United States)

    Moye, Michael D.; And Others

    This curriculum guide is designed to offer guidelines along with supporting resources and teaching ideas from which the local secondary instructor can extract a cosmetology curriculum that meets local needs. Following an outline of the philosophy and goals underlying state and local vocational education programs in Georgia, the purpose and…

  10. CERN honours its guides

    CERN Multimedia

    2004-01-01

    At the end of January, CERN's guides were rewarded for their devotion to the Laboratory. They have a passion for their work, know CERN inside-out and for 40 years have shown people of all ages and nationalities, from all walks of life, around the Laboratory. Who are they? Why, the CERN guides, of course. On 27 January, ten of CERN's 180 guides received special honours for their impressive number of guided tours in 2003. Presenting the awards in the Microcosm hall, CERN's Director-General Robert Aymar congratulated the winners on the key role they play with respect to the general public. "CERN would be nothing without you who show them its activities," he stressed. CERN's Director-General Robert Aymar congratulates Alberto Ribon for his tally of over 40 visits in the course of 2003.One of the prizes was the book «The Particle Odyssey». Here the book's co-author Christine Sutton dedicates it for Sijin Qian. Tzanko Spassoff (PH) and retired staff members Klaus Batzner and Antonio Francano wo...

  11. Sensor Characteristics Reference Guide

    Energy Technology Data Exchange (ETDEWEB)

    Cree, Johnathan V.; Dansu, A.; Fuhr, P.; Lanzisera, Steven M.; McIntyre, T.; Muehleisen, Ralph T.; Starke, M.; Banerjee, Pranab; Kuruganti, T.; Castello, C.

    2013-04-01

    The Buildings Technologies Office (BTO), within the U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), is initiating a new program in Sensor and Controls. The vision of this program is: • Buildings operating automatically and continuously at peak energy efficiency over their lifetimes and interoperating effectively with the electric power grid. • Buildings that are self-configuring, self-commissioning, self-learning, self-diagnosing, self-healing, and self-transacting to enable continuous peak performance. • Lower overall building operating costs and higher asset valuation. The overarching goal is to capture 30% energy savings by enhanced management of energy consuming assets and systems through development of cost-effective sensors and controls. One step in achieving this vision is the publication of this Sensor Characteristics Reference Guide. The purpose of the guide is to inform building owners and operators of the current status, capabilities, and limitations of sensor technologies. It is hoped that this guide will aid in the design and procurement process and result in successful implementation of building sensor and control systems. DOE will also use this guide to identify research priorities, develop future specifications for potential market adoption, and provide market clarity through unbiased information

  12. Drush User's Guide

    CERN Document Server

    Requena, Juan Pablo Novillo

    2012-01-01

    A practical guide full of examples and step-by-step instructions to start using Drush right from chapter 1. Drupal developers or themers who understand Drupal administration's basic concepts. Drush can make building any kind of website quicker and easier, no matter if it is a development environment, beta, a simple blog or a complex system.

  13. Ozone Layer Educator's Guide.

    Science.gov (United States)

    Environmental Protection Agency, Washington, DC.

    This guide has been developed through a collaborative effort involving the U.S. Environmental Protection Agency (EPA), the National Oceanic and Atmospheric Administration (NOAA), and the National Aeronautics and Space Administration (NASA). It is part of an ongoing commitment to ensure that the results of scientific research on ozone depletion are…

  14. Automated Accounting. Instructor Guide.

    Science.gov (United States)

    Moses, Duane R.

    This curriculum guide was developed to assist business instructors using Dac Easy Accounting College Edition Version 2.0 software in their accounting programs. The module consists of four units containing assignment sheets and job sheets designed to enable students to master competencies identified in the area of automated accounting. The first…

  15. Destination: Paraguay. Study Guide.

    Science.gov (United States)

    Rhoades, Roxanne

    This guide offers a closer look at Paraguay as a landlocked republic in the heart of South America. The activities emphasize the interaction between the people and their land and pertain to three academic levels. Activities for grades 3-5 include: (1) "Packing for Paraguay"; (2) "Where in the World Are We Going and How in the World Will We Get…

  16. Follow the guide!

    CERN Multimedia

    2003-01-01

    For once it was the turn of the CERN guides to be shown around. A special tour had been organised for their annual outing on 24 June 2003, the aim of which was to go behind the scenes at research centres similar to CERN and discover the secrets of their public communications activities. The first stop was the European Synchrotron Radiation Facility (ESRF) in Grenoble, where the twenty or so CERN guides were welcomed by Dominique Cornujeols, head of communication at ESRF, who explained the Facility's history and purpose and how it operates before they were taken on a tour of the actual installations. CERN guides are welcomed to the ESRF (European Synchrotron Radiation Facility).The second visit of this trip to the Grenoble region was to the centre for science, technology and industry (CCSTI). "The people in charge at CCSTI showed us their day-to-day work in science and technology workshops", explains Stephan Petit, one of the guides. These workshops allow the public to discuss fundamental issues relating to a ...

  17. Architectural Guide of Jordan

    DEFF Research Database (Denmark)

    Hilberth, Thomas Roger

    2016-01-01

    Architectural and cultural guidebook for Jordan that also includes a view on the Syrian refugee situation, especially in the large UNHCR camp of Zaatari. The guide book is a preparatory study for a field trip our master studio undertook to the Hashemite Kingdom of Jordan in Fall 2016....

  18. Steroids. A Resource Guide.

    Science.gov (United States)

    New York State Education Dept., Albany. Bureau of School Health Education and Services.

    This guide provides information on steroid use as well as prevention and intervention strategies. It is intended to serve as a supplement to drug abuse education and prevention programs in elementary and secondary schools and as the basis for local curriculum development and instructional activities. The following topics are covered: (1) history…

  19. Welding. Student Learning Guide.

    Science.gov (United States)

    Palm Beach County Board of Public Instruction, West Palm Beach, FL.

    This student learning guide contains 30 modules for completing a course in welding. It is designed especially for use in secondary schools in Palm Beach County, Florida. Each module covers one task, and consists of a purpose, performance objective, enabling objectives, learning activities keyed to resources, information sheets, student self-check…

  20. Field Guide to Radiometry

    CERN Document Server

    Grant, Barbara

    2011-01-01

    Written from a systems engineering perspective, this SPIE Field Guide covers topics in optical radiation propagation, material properties, sources, detectors, system components, measurement, calibration, and photometry. The book's organization and extensive collection of diagrams, tables, and graphs will enable the reader to efficiently identify and apply relevant information to radiometric problems arising amid the demands of today's fast-paced technical environment.