WorldWideScience

Sample records for challenging assembly integration

  1. Integrated magnetic transformer assembly

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to an integrated magnetics transformer assembly comprising a first magnetically permeable core forming a first substantially closed magnetic flux path and a second magnetically permeable core forming a second substantially closed magnetic flux path. A first input...... inductor winding is wound around a first predetermined segment of the first magnetically permeable core and a second input inductor winding is wound around a first predetermined segment of the second magnetically permeable core. The integrated magnetics transformer assembly further comprises a first output......-winding of the first output inductor winding and the first half-winding of the second output inductor winding are configured to produce aligned, i.e. in the same direction, magnetic fluxes through the first substantially closed magnetic flux path. The integrated magnetics transformer assembly is well- suited for use...

  2. Integral nuclear fuel element assembly

    International Nuclear Information System (INIS)

    Schluderberg, D. C.

    1985-01-01

    An integral nuclear fuel element assembly utilizes longitudinally finned fuel pins. The continuous or interrupted fins of the fuel pins are brazed to fins of juxtaposed fuel pins or directly to the juxtaposed fuel pins or both. The integrally brazed fuel assembly is designed to satisfy the thermal and hydraulic requirements of a fuel assembly lattice having moderator to fuel atom ratios required to achieve high conversion and breeding ratios

  3. The NIRspec assembly integration and test status

    Science.gov (United States)

    Wettemann, Thomas; Ehrenwinkler, Ralf; Johnson, Thomas E.; Maschmann, Marc; Mosner, Peter; te Plate, Maurice; Rödel, Andreas

    2017-11-01

    The Near-Infrared Spectrograph (NIRSpec) is one of the four instruments on the James Webb Space Telescope (JWST) scheduled for launch in 2018. NIRSpec has been manufactured and tested by an European industrial consortium led by Airbus Defence and Space and delivered to the European Space Agency (ESA) and NASA in September 2013. Since then it has successfully been integrated into the JWST Integrated Science Instrument Module (ISIM) and is currently in ISIM Cryo-Vacuum Test#2. Since however two of its most important assemblies, the Focal Plane Assembly (FPA) and the Micro-Shutter Assembly (MSA) need to be replaced by new units we will present the status of the instrument, the status of its new flight assemblies in manufacturing and testing and give an outlook on the planned exchange activities and the following instrument re-verification.

  4. Integrating succession and community assembly perspectives.

    Science.gov (United States)

    Chang, Cynthia; HilleRisLambers, Janneke

    2016-01-01

    Succession and community assembly research overlap in many respects, such as through their focus on how ecological processes like dispersal, environmental filters, and biotic interactions influence community structure. Indeed, many recent advances have been made by successional studies that draw on modern analytical techniques introduced by contemporary community assembly studies. However, community assembly studies generally lack a temporal perspective, both on how the forces structuring communities might change over time and on how historical contingency (e.g. priority effects and legacy effects) and complex transitions (e.g. threshold effects) might alter community trajectories. We believe a full understanding of the complex interacting processes that shape community dynamics across large temporal scales can best be achieved by combining concepts, tools, and study systems into an integrated conceptual framework that draws upon both succession and community assembly theory.

  5. Actinides integral measurements on FCA assemblies

    International Nuclear Information System (INIS)

    Mukaiyama, Takehiko; Okajima, Shigeaki

    1984-01-01

    Actinide integral measurements were performed on eight assemblies of FCA where neutron energy spectra were shifted systematically from soft to hard in order to evaluate and modify the nuclear cross section data of major actinides. Experimental values on actinide fission rates and sample reactivity worths are compared with the calculated values using JENDL-2 and ENDF/B-V (or IV) data sets. (author)

  6. Grand Challenges of Enterprise Integration

    Energy Technology Data Exchange (ETDEWEB)

    Brosey, W.D; Neal, R.E.; Marks, D.

    2001-04-01

    Enterprise Integration connects and combines people, processes, systems, and technologies to ensure that the right people and the right processes have the right information and the right resources at the right time. A consensus roadmap for Technologies for Enterprise Integration was created as part of an industry/government/academia partnership in the Integrated Manufacturing Technology Initiative (IMTI). Two of the grand challenges identified by the roadmapping effort will be addressed here--Customer Responsive Enterprises and Totally Connected Enterprises. Each of these challenges is briefly discussed as to the current state of industry and the future vision as developed in the roadmap.

  7. Challenges of decentralisation in Ghana: district assembly's ...

    African Journals Online (AJOL)

    The 1992 Constitution of the Republic of Ghana and the various legislations on decentralisation articulate the explicit objectives of the policy which includes responsiveness to community needs. The rationale behind Ghana's decentralisation programme and the functions of the District Assemblies (DAs) therefore provide a ...

  8. Challenges of Integrating NASA's Space Communications Networks

    Science.gov (United States)

    Reinert, Jessica; Barnes, Patrick

    2013-01-01

    The transition to new technology, innovative ideas, and resistance to change is something that every industry experiences. Recent examples of this shift are changing to using robots in the assembly line construction of automobiles or the increasing use of robotics for medical procedures. Most often this is done with cost-reduction in mind, though ease of use for the customer is also a driver. All industries experience the push to increase efficiency of their systems; National Aeronautics and Space Administration (NASA) and the commercial space industry are no different. NASA space communication services are provided by three separately designed, developed, maintained, and operated communications networks known as the Deep Space Network (DSN), Near Earth Network (NEN) and Space Network (SN). The Space Communications and Navigation (SCaN) Program is pursuing integration of these networks and has performed a variety of architecture trade studies to determine what integration options would be the most effective in achieving a unified user mission support organization, and increase the use of common operational equipment and processes. The integration of multiple, legacy organizations and existing systems has challenges ranging from technical to cultural. The existing networks are the progeny of the very first communication and tracking capabilities implemented by NASA and the Jet Propulsion Laboratory (JPL) more than 50 years ago and have been customized to the needs of their respective user mission base. The technical challenges to integrating the networks are many, though not impossible to overcome. The three distinct networks provide the same types of services, with customizable data rates, bandwidth, frequencies, and so forth. The differences across the networks have occurred in effort to satisfy their user missions' needs. Each new requirement has made the networks more unique and harder to integrate. The cultural challenges, however, have proven to be a

  9. Challenges of Integrating NASAs Space Communication Networks

    Science.gov (United States)

    Reinert, Jessica M.; Barnes, Patrick

    2013-01-01

    The transition to new technology, innovative ideas, and resistance to change is something that every industry experiences. Recent examples of this shift are changing to using robots in the assembly line construction of automobiles or the increasing use of robotics for medical procedures. Most often this is done with cost-reduction in mind, though ease of use for the customer is also a driver. All industries experience the push to increase efficiency of their systems; National Aeronautics and Space Administration (NASA) and the commercial space industry are no different. NASA space communication services are provided by three separately designed, developed, maintained, and operated communications networks known as the Deep Space Network (DSN), Near Earth Network (NEN) and Space Network (SN). The Space Communications and Navigation (SCaN) Program is pursuing integration of these networks and has performed a variety of architecture trade studies to determine what integration options would be the most effective in achieving a unified user mission support organization, and increase the use of common operational equipment and processes. The integration of multiple, legacy organizations and existing systems has challenges ranging from technical to cultural. The existing networks are the progeny of the very first communication and tracking capabilities implemented by NASA and the Jet Propulsion Laboratory (JPL) more than 50 years ago and have been customized to the needs of their respective user mission base. The technical challenges to integrating the networks are many, though not impossible to overcome. The three distinct networks provide the same types of services, with customizable data rates, bandwidth, frequencies, and so forth. The differences across the networks have occurred in effort to satisfy their user missions' needs. Each new requirement has made the networks more unique and harder to integrate. The cultural challenges, however, have proven to be a

  10. Challenges in horizontal model integration.

    Science.gov (United States)

    Kolczyk, Katrin; Conradi, Carsten

    2016-03-11

    Systems Biology has motivated dynamic models of important intracellular processes at the pathway level, for example, in signal transduction and cell cycle control. To answer important biomedical questions, however, one has to go beyond the study of isolated pathways towards the joint study of interacting signaling pathways or the joint study of signal transduction and cell cycle control. Thereby the reuse of established models is preferable, as it will generally reduce the modeling effort and increase the acceptance of the combined model in the field. Obtaining a combined model can be challenging, especially if the submodels are large and/or come from different working groups (as is generally the case, when models stored in established repositories are used). To support this task, we describe a semi-automatic workflow based on established software tools. In particular, two frequent challenges are described: identification of the overlap and subsequent (re)parameterization of the integrated model. The reparameterization step is crucial, if the goal is to obtain a model that can reproduce the data explained by the individual models. For demonstration purposes we apply our workflow to integrate two signaling pathways (EGF and NGF) from the BioModels Database.

  11. CFD Analysis for Advanced Integrated Head Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Won Ho; Kang, Tae Kyo; Cho, Yeon Ho; Kim, Hyun Min [KEPCO Engineering and Construction Co., Daejeon (Korea, Republic of)

    2016-10-15

    The Integrated Head Assembly (IHA) is permanently installed on the reactor vessel closure head during the normal plant operation and refueling operation. It consists of a number of systems and components such as the head lifting system, seismic support system, Control Element Drive Mechanism (CEDM) cooling system, cable support system, cooling shroud assemblies. With the operating experiences of the IHA, the needs for the design change to the current APR1400 IHA arouse to improve the seismic resistance and to accommodate the convenient maintenance. In this paper, the effects of the design changes were rigorously studied for the various sizes of the inlet openings to assure the proper cooling of the CEDMs. And the system pressure differentials and required flow rate for the CEDM cooling fan were analyzed regarding the various operating conditions for determining the capacity of the fan. As a part of the design process of the AIHA, the number of air inlets and baffle regions are reduced by simplifying the design of the APR1400 IHA. The design change of the baffle regions has been made such that the maximum possible space are occupied inside the IHA cooling shroud shell while avoiding the interference with CEDMs. So, only the air inlet opening was studied for the design change to supply a sufficient cooling air flow for each CEDM. The size and location of the air inlets in middle cooling shroud assembly were determined by the CFD analyses of the AIHA. And the case CFD analyses were performed depending on the ambient air temperature and fan operating conditions. The size of the air inlet openings is increased by comparison with the initial AIHA design, and it is confirmed that the cooling air flow rate for each CEDM meet the design requirement of 800 SCFM ± 10% with the increased air inlets. At the initial analysis, the fan outlet flow rate was assumed as 48.3 lbm/s, but the result revealed that the less outflow rate at the fan is enough to meet the design requirement

  12. Localized synthesis, assembly and integration of silicon nanowires

    Science.gov (United States)

    Englander, Ongi

    organization, alignment, and assembly. The integrated nanoelectrormechanical system was found to be mechanically resilient as it proved to successfully withstand a wide variety of post-processing steps, including manipulations and examinations under scanning and transmission electron microscopes and aqueous processing, although a super critical drying step is necessary to preserve the integrated system during the drying process. Electrical characterization of the system proved challenging due to low carrier concentration and possible transport issues at the nano-micro interface. Nonetheless, in a proof-of-concept demonstration, the system was functionalized and tested for a hydrogen sensing application.

  13. Genome Assembly Forensics: Metrics for Assessing Assembly Correctness (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Pop, Mihai

    2011-10-13

    University of Maryland's Mihai Pop on Genome Assembly Forensics: Metrics for Assessing Assembly Correctness at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  14. Renewable energy integration challenges and solutions

    CERN Document Server

    Hossain, Jahangir

    2014-01-01

    This book examines challenges involved in the integration of renewable energy into existing electricity grids. It provides models of power systems to show how the integration will effect conventional grids and various solutions to minimize the impacts.

  15. Apparatus for integrated fuel assembly inspection system

    International Nuclear Information System (INIS)

    Ahmed, H.J.; Burchill, S.R.

    1988-01-01

    In a fuel assembly inspection apparatus, the combination is described comprising: (a) an elongated fixture mounted in a stationary upright position; (b) upper means mounted to an upper portion of the fixture and lower means mounted adjacent to a lower portion of the fixture, the upper and lower means being disposed outwardly from a side of the fixture for supporting a nuclear fuel assembly therebetween and extending along the side of the fixture; (c) a bottom carriage having a central opening adapted to receive the fuel assembly therethrough when supported between the upper and lower means such that the bottom carriage being connected only to, and extending in cantilever fashion outwardly from, the side of the fixture for generally vertical movement along the side of the fixture and along the fuel assembly extending along the side of the fixture; (d) drive means for selectively moving the bottom carriage; and (e) means disposed on the bottom carriage for measuring the envelop, of the fuel assembly when the bottom carriage is moved to and stationed at selected axial positions along the fuel assembly

  16. Integrated Environmental Modelling: Human decisions, human challenges

    Science.gov (United States)

    Glynn, Pierre D.

    2015-01-01

    Integrated Environmental Modelling (IEM) is an invaluable tool for understanding the complex, dynamic ecosystems that house our natural resources and control our environments. Human behaviour affects the ways in which the science of IEM is assembled and used for meaningful societal applications. In particular, human biases and heuristics reflect adaptation and experiential learning to issues with frequent, sharply distinguished, feedbacks. Unfortunately, human behaviour is not adapted to the more diffusely experienced problems that IEM typically seeks to address. Twelve biases are identified that affect IEM (and science in general). These biases are supported by personal observations and by the findings of behavioural scientists. A process for critical analysis is proposed that addresses some human challenges of IEM and solicits explicit description of (1) represented processes and information, (2) unrepresented processes and information, and (3) accounting for, and cognizance of, potential human biases. Several other suggestions are also made that generally complement maintaining attitudes of watchful humility, open-mindedness, honesty and transparent accountability. These suggestions include (1) creating a new area of study in the behavioural biogeosciences, (2) using structured processes for engaging the modelling and stakeholder communities in IEM, and (3) using ‘red teams’ to increase resilience of IEM constructs and use.

  17. Heterogeneous MEMS device assembly and integration

    Science.gov (United States)

    Topart, Patrice; Picard, Francis; Ilias, Samir; Alain, Christine; Chevalier, Claude; Fisette, Bruno; Paultre, Jacques E.; Généreux, Francis; Legros, Mathieu; Lepage, Jean-François; Laverdière, Christian; Ngo Phong, Linh; Caron, Jean-Sol; Desroches, Yan

    2014-03-01

    In recent years, smart phone applications have both raised the pressure for cost and time to market reduction, and the need for high performance MEMS devices. This trend has led the MEMS community to develop multi-die packaging of different functionalities or multi-technology (i.e. wafer) approaches to fabricate and assemble devices respectively. This paper reports on the fabrication, assembly and packaging at INO of various MEMS devices using heterogeneous assembly at chip and package-level. First, the performance of a giant (e.g. about 3 mm in diameter), electrostatically actuated beam steering mirror is presented. It can be rotated about two perpendicular axes to steer an optical beam within an angular cone of up to 60° in vector scan mode with an angular resolution of 1 mrad and a response time of 300 ms. To achieve such angular performance relative to mirror size, the microassembly was performed from sub-components fabricated from 4 different wafers. To combine infrared detection with inertial sensing, an electroplated proof mass was flip-chipped onto a 256×1 pixel uncooled bolometric FPA and released using laser ablation. In addition to the microassembly technology, performance results of packaged devices are presented. Finally, to simulate a 3072×3 pixel uncooled detector for cloud and fire imaging in mid and long-wave IR, the staggered assembly of six 512×3 pixel FPAs with a less than 50 micron pixel co-registration is reported.

  18. Integration in psychotherapy: Reasons and challenges.

    Science.gov (United States)

    Fernández-Álvarez, Héctor; Consoli, Andrés J; Gómez, Beatriz

    2016-11-01

    Although integration has been formally influencing the field of psychotherapy since the 1930s, its impact gained significant momentum during the 1980s. Practical, theoretical, and scientific reasons help to explain the growing influence of integration in psychotherapy. The field of psychotherapy is characterized by many challenges which integration may change into meaningful opportunities. Nonetheless, many obstacles remain when seeking to advance integration. To appreciate the strength of integration in psychotherapy we describe an integrative, comprehensive approach to service delivery, research, and training. We then discuss the role of integration in the future of psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  19. Challenges of Aircraft Design Integration

    Science.gov (United States)

    2003-03-01

    predicted by the conceptual stick model and the full FEM of the Challenger wing without winglets . Advanced aerodynamic wing design methods To design wings...Piperni, E. Laurendeau Advanced Aerodynamics Bombardier Aerospace 400 CMte Vertu Road Dorval, Quebec, Canada, H4S 1Y9 Fassi.Kafyeke @notes.canadair.ca Tel...514) 855-7186 Abstract The design of a modern airplane brings together many disciplines: structures, aerodynamics , controls, systems, propulsion

  20. Integrated Modular Avionics: The Challenges

    Science.gov (United States)

    Charrier, O.

    2009-05-01

    The need to reduce Space, Weight, and Power (SWaP) across the embedded market leads many Systems Suppliers to run multiple applications on the same processor. The concept seems deceptively simple. However, a lack of experience using this approach, may lead to many mistakes, resulting in unacceptable system performance and unacceptable costs. The objective of this paper is to review the challenges of controlling the execution of multiple applications on the same processor in a Safety or Mission Critical context and, based on return of experiences, point out some of the common mistakes and the limit of what an operating system can control. As no-one has an unlimited budget, the ability to develop and verify such system at reasonable cost, reduced risk, and re-use of the expended effort will be emphasized.

  1. Metagenome Assembly at the DOE JGI (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Chain, Patrick

    2011-10-13

    Patrick Chain of DOE JGI at LANL, Co-Chair of the Metagenome-specific Assembly session, on Metagenome Assembly at the DOE JGIat the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  2. Structural characterisation of medically relevant protein assemblies by integrating mass spectrometry with computational modelling.

    Science.gov (United States)

    Politis, Argyris; Schmidt, Carla

    2018-03-20

    Structural mass spectrometry with its various techniques is a powerful tool for the structural elucidation of medically relevant protein assemblies. It delivers information on the composition, stoichiometries, interactions and topologies of these assemblies. Most importantly it can deal with heterogeneous mixtures and assemblies which makes it universal among the conventional structural techniques. In this review we summarise recent advances and challenges in structural mass spectrometric techniques. We describe how the combination of the different mass spectrometry-based methods with computational strategies enable structural models at molecular levels of resolution. These models hold significant potential for helping us in characterizing the function of protein assemblies related to human health and disease. In this review we summarise the techniques of structural mass spectrometry often applied when studying protein-ligand complexes. We exemplify these techniques through recent examples from literature that helped in the understanding of medically relevant protein assemblies. We further provide a detailed introduction into various computational approaches that can be integrated with these mass spectrometric techniques. Last but not least we discuss case studies that integrated mass spectrometry and computational modelling approaches and yielded models of medically important protein assembly states such as fibrils and amyloids. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

  3. Assembly and method for testing the integrity of stuffing tubes

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, E.F.

    1996-12-31

    A stuffing tube integrity checking assembly includes first and second annular seals, with each seal adapted to be positioned about a stuffing tube penetration component. An annular inflation bladder is provided, the bladder having a slot extending longitudinally there along and including a separator for sealing the slot. A first valve is in fluid communication with the bladder for introducing pressurized fluid to the space defined by the bladder when mounted about the tube. First and second releasible clamps are provided. Each clamp assembly is positioned about the bladder for securing the bladder to one of the seals for thereby establishing a fluid-tight chamber about the tube.

  4. Multispectral Thermal Imager Optical Assembly Performance and Integration of the Flight Focal Plane Assembly

    International Nuclear Information System (INIS)

    Blake, Dick; Byrd, Don; Christensen, Wynn; Henson, Tammy; Krumel, Les; Rappoport, William; Shen, Gon-Yen

    1999-01-01

    The Multispectral Thermal Imager Optical Assembly (OA) has been fabricated, assembled, successfully performance tested, and integrated into the flight payload structure with the flight Focal Plane Assembly (FPA) integrated and aligned to it. This represents a major milestone achieved towards completion of this earth observing E-O imaging sensor that is to be operated in low earth orbit. The OA consists of an off-axis three mirror anastigmatic (TMA) telescope with a 36 cm unobscured clear aperture, a wide-field-of-view (WFOV) of 1.82 along the direction of spacecraft motion and 1.38 across the direction of spacecraft motion. It also contains a comprehensive on-board radiometric calibration system. The OA is part of a multispectral pushbroom imaging sensor which employs a single mechanically cooled focal plane with 15 spectral bands covering a wavelength range from 0.45 to 10.7 m. The OA achieves near diffraction-limited performance from visible to the long-wave infrared (LWIR) wavelengths. The two major design drivers for the OA are 80% enpixeled energy in the visible bands and radiometric stability. Enpixeled energy in the visible bands also drove the alignment of the FPA detectors to the OA image plane to a requirement of less than 20 m over the entire visible detector field of view (FOV). Radiometric stability requirements mandated a cold Lyot stop for stray light rejection and thermal background reduction. The Lyot stop is part of the FPA assembly and acts as the aperture stop for the imaging system. The alignment of the Lyot stop to the OA drove the centering and to some extent the tilt alignment requirements of the FPA to the OA

  5. Photonic integrated circuits: new challenges for lithography

    Science.gov (United States)

    Bolten, Jens; Wahlbrink, Thorsten; Prinzen, Andreas; Porschatis, Caroline; Lerch, Holger; Giesecke, Anna Lena

    2016-10-01

    In this work routes towards the fabrication of photonic integrated circuits (PICs) and the challenges their fabrication poses on lithography, such as large differences in feature dimension of adjacent device features, non-Manhattan-type features, high aspect ratios and significant topographic steps as well as tight lithographic requirements with respect to critical dimension control, line edge roughness and other key figures of merit not only for very small but also for relatively large features, are highlighted. Several ways those challenges are faced in today's low-volume fabrication of PICs, including the concept multi project wafer runs and mix and match approaches, are presented and possible paths towards a real market uptake of PICs are discussed.

  6. ITER design, integration and assembly studies assisted by virtual reality

    Energy Technology Data Exchange (ETDEWEB)

    Keller, D., E-mail: delphine.keller@cea.fr [CEA, IRFM, F-13108 St-Paul-Lez-Durance (France); ITER Organization, Route de Vinon-sur-Verdon, F-13115 St-Paul-Lez-Durance (France); Doceul, L.; Ferlay, F.; Jiolat, G. [CEA, IRFM, F-13108 St-Paul-Lez-Durance (France); Cordier, J.J.; Kuehn, I.; Manfreo, B.; Reich, J. [ITER Organization, Route de Vinon-sur-Verdon, F-13115 St-Paul-Lez-Durance (France)

    2013-10-15

    Highlights: ► VR technologies applied to Fusion enable to better and faster understand integration issues. ► Problems are solved and validated on a numerical mock up. ► Integration and accessibility issues can be identified in the earliest design. ► VR technologies are very helpful for assembly and maintenance operation simulations. ► New tools for real time simulations of hands-on operations are currently under development. -- Abstract: In a project like ITER where schedule, resources and cost is continuously optimized, emphasis has to be put on developing long lead items first while keeping other designs very low in definition. Hence, at a particular stage of the project, several components have to coexist in the integrated system while handling different level of maturity. Therefore, all the difficulty consists in managing the interfaces between all these components and to minimize the risk of design changes on the most advanced components. As a future exploitant, ITER is in charge of managing these interfaces and to ensure that maintenance of especially safety important class components (SIC) is feasible. These operation and maintenance constraints have to be taken into account since the earliest design of the components itselves. In this context, CEA IRFM is taking the benefit of using its virtual reality (VR) platform and simulation tools to assist ITER Organization in improving the efficiency of the inconsistencies identification and the machine sub-system design optimization. Currently, two contracts are on-going: the first one concerns the cryostat and in-vessel components; the second one concerns the overall Tokamak (TKM) and diagnostic buildings. This paper describes how VR tools applied to fusion and especially to ITER can help design and Integration with taking into account assembly and maintenance requirements at early stage in the design of complex systems.

  7. ITER design, integration and assembly studies assisted by virtual reality

    International Nuclear Information System (INIS)

    Keller, D.; Doceul, L.; Ferlay, F.; Jiolat, G.; Cordier, J.J.; Kuehn, I.; Manfreo, B.; Reich, J.

    2013-01-01

    Highlights: ► VR technologies applied to Fusion enable to better and faster understand integration issues. ► Problems are solved and validated on a numerical mock up. ► Integration and accessibility issues can be identified in the earliest design. ► VR technologies are very helpful for assembly and maintenance operation simulations. ► New tools for real time simulations of hands-on operations are currently under development. -- Abstract: In a project like ITER where schedule, resources and cost is continuously optimized, emphasis has to be put on developing long lead items first while keeping other designs very low in definition. Hence, at a particular stage of the project, several components have to coexist in the integrated system while handling different level of maturity. Therefore, all the difficulty consists in managing the interfaces between all these components and to minimize the risk of design changes on the most advanced components. As a future exploitant, ITER is in charge of managing these interfaces and to ensure that maintenance of especially safety important class components (SIC) is feasible. These operation and maintenance constraints have to be taken into account since the earliest design of the components itselves. In this context, CEA IRFM is taking the benefit of using its virtual reality (VR) platform and simulation tools to assist ITER Organization in improving the efficiency of the inconsistencies identification and the machine sub-system design optimization. Currently, two contracts are on-going: the first one concerns the cryostat and in-vessel components; the second one concerns the overall Tokamak (TKM) and diagnostic buildings. This paper describes how VR tools applied to fusion and especially to ITER can help design and Integration with taking into account assembly and maintenance requirements at early stage in the design of complex systems

  8. The challenges of lean manufacturing implementation in kitting assembly

    Science.gov (United States)

    Fansuri, A. F. H.; Rose, A. N. M.; Nik Mohamed, N. M. Z.; Ahmad, H.

    2017-10-01

    Literature studies shows that lean manufacturing goes way back with the original founder Eli Whitney in year 1799. The main purpose of lean manufacturing is to identify and eliminate waste in production. The application of lean manufacturing can be carried out in any industrial processes with regards to the understanding of lean principles, theories and practices. Kitting is one of the important aspects in a successful production. The continuous supply of materials from store to production has to be systematic and able to achieve lean standard for it to be successful. The objective of this paper is to review the implementation of lean manufacturing in kitting assembly. Previous papers show that, the implementation of lean manufacturing in kitting assembly may be beneficial to the organization such as reduce in space occupancy, part shortages, lead time and manpower. Based on previous research, some industries may tend to change between kitting and line stocking which are due to lack of understanding when implementing kitting and causes longer lead time and materials overflow in store. With a proper understanding on what to kit, where to kit, how to kit, why to kit and who kits the material with a standardised process flow may ensure the success of kitting.

  9. Assembly and integration of geo-scientific knowledge and arguments

    International Nuclear Information System (INIS)

    Gierszewki, P.; Gautschi, A.; Nguyen, T.S.; Laaksohaju, M.; Rohlig, K.J.; Peake, T.; Peltier, R.; Pitkanen, P.; Skagius Elert, K.; Sykes, J.F.

    2007-01-01

    The purpose of this working group was to consider the assembly and integration of geo-scientific knowledge and arguments. In an introductory presentation, K. Skagius Elert presented 'Assessment of Uncertainty and Confidence in Site Descriptive Models Experience from the On-going Site Investigation Programme in Sweden'. The detailed description of concepts and procedures established at SKB for the development of a Site Descriptive Model (SDM) provided a starting point for the discussion of the working group. The SDM components and the procedures to achieve them were used as 'references' for the discussion of comparable elements in other national programmes. The observations have been placed into two broad themes: 1. How to manage the integration? 2. How to handle uncertainties? No specific prescription was identified for either of these questions; rather a range of suggestions were noted based on experience. The appropriate solution will depend on the organisation, the site, the state of the programme, and other factors. A final observation from the working group was on the handling of evolution of the site with time. This topic incorporates aspects of both site integration and uncertainty management. Specifically, the integrated site description model (SDM) noted above represents a description of the site as it presently exists. This description takes into account the site history, but does not describe its evolution. The latter involves a number of uncertainties. This time evolution of the site can be described through Scenarios. The definition of scenarios, similar to the definition of the SDM, is an integrated and multidisciplinary process in order to ensure a self-consistent description. It will involve use of common assumptions. Since it involves the future and the associated uncertainties, it can be useful to draw on expert panels to help define the key assumptions and outlines for scenarios. (authors)

  10. Challenges and solutions ensuring EUVL photomask integrity

    Science.gov (United States)

    Brux, O.; Dreß, P.; Schmalfuß, H.; Jonckheere, R.; Koolen-Hermkens, W.

    2012-06-01

    Industry roadmaps indicate that the introduction of Extreme Ultraviolet Lithography (EUVL) is on track for high volume manufacturing. Although, there has been significant progress in each of the individual subsets of the EUVL infrastructure, the absolute management of the process outside of the scanner and up to the point-of-exposure has been highlighted as critical requirement for the adoption of EUVL. Significant changes in the EUV system environment and mask architecture are driving a zero process tolerance level. Any unforeseen contamination introduced to the scanner environment from the EUV mask could cause considerable downtime and yield loss. Absolute mask integrity at the point-of-exposure must be guaranteed. EUV mask cleaning processes-of-record have been developed and introduced to the industry [1]. The issue is not longer "how to clean the mask" but, "how to keep it clean". With the introduction of EUVL, mask cleanliness extends out beyond the traditional mask cleaning tool. Complete control of contamination and/or particles during transportation, handling and storage will require a holistic approach to mask management. A new environment specifically for EUV mask integrity must be developed and fully tested for the sub 16nm half-pitch node introduction. The SUSS MaskTrack Pro (MTP) InSync was introduced as the solution for EUV mask integrity. SUSS demonstrated the fully automated handling of EUV masks into and out of a Dual Pod System [2]. Intrinsic cleanliness of each individual handling and storage step of the inner pod (EIP) and EUV mask inside the MTP InSync Tool was investigated and reported. A target specification of a PRP cleaning by measuring particles down to 150nm size. A dynamic capture rate of larger 97% at 200nm particle size based on PSLs was achieved; for EIP cleaning, a dry-cleaning technology is under investigation. During feasibility studies high particle removal efficiency (PRE) results larger 99% has been achieved for particles down

  11. Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine

    Directory of Open Access Journals (Sweden)

    Wenming Xiao

    2016-04-01

    Full Text Available Even though each of us shares more than 99% of the DNA sequences in our genome, there are millions of sequence codes or structure in small regions that differ between individuals, giving us different characteristics of appearance or responsiveness to medical treatments. Currently, genetic variants in diseased tissues, such as tumors, are uncovered by exploring the differences between the reference genome and the sequences detected in the diseased tissue. However, the public reference genome was derived with the DNA from multiple individuals. As a result of this, the reference genome is incomplete and may misrepresent the sequence variants of the general population. The more reliable solution is to compare sequences of diseased tissue with its own genome sequence derived from tissue in a normal state. As the price to sequence the human genome has dropped dramatically to around $1000, it shows a promising future of documenting the personal genome for every individual. However, de novo assembly of individual genomes at an affordable cost is still challenging. Thus, till now, only a few human genomes have been fully assembled. In this review, we introduce the history of human genome sequencing and the evolution of sequencing platforms, from Sanger sequencing to emerging “third generation sequencing” technologies. We present the currently available de novo assembly and post-assembly software packages for human genome assembly and their requirements for computational infrastructures. We recommend that a combined hybrid assembly with long and short reads would be a promising way to generate good quality human genome assemblies and specify parameters for the quality assessment of assembly outcomes. We provide a perspective view of the benefit of using personal genomes as references and suggestions for obtaining a quality personal genome. Finally, we discuss the usage of the personal genome in aiding vaccine design and development, monitoring host

  12. Evaluation of the Cow Rumen Metagenome: Assembly by Single Copy Gene Analysis and Single Cell Genome Assemblies (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Sczyrba, Alex

    2011-10-13

    DOE JGI's Alex Sczyrba on "Evaluation of the Cow Rumen Metagenome" and "Assembly by Single Copy Gene Analysis and Single Cell Genome Assemblies" at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  13. MetaVelvet: An Extension of Velvet Assembler to de novo Metagenome Assembly from Short Sequence Reads (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Sakakibara, Yasumbumi

    2011-10-13

    Keio University's Yasumbumi Sakakibara on "MetaVelvet: An Extension of Velvet Assembler to de novo Metagenome Assembly from Short Sequence Reads" at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  14. INTEGRATED APPROACH TO GENERATION OF PRECEDENCE RELATIONS AND PRECEDENCE GRAPHS FOR ASSEMBLY SEQUENCE PLANNING

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    An integrated approach to generation of precedence relations and precedence graphs for assembly sequence planning is presented, which contains more assembly flexibility. The approach involves two stages. Based on the assembly model, the components in the assembly can be divided into partially constrained components and completely constrained components in the first stage, and then geometric precedence relation for every component is generated automatically. According to the result of the first stage, the second stage determines and constructs all precedence graphs. The algorithms of these two stages proposed are verified by two assembly examples.

  15. Challenges and opportunities in understanding microbial communities with metagenome assembly (accompanied by IPython Notebook tutorial)

    Science.gov (United States)

    Howe, Adina; Chain, Patrick S. G.

    2015-01-01

    Metagenomic investigations hold great promise for informing the genetics, physiology, and ecology of environmental microorganisms. Current challenges for metagenomic analysis are related to our ability to connect the dots between sequencing reads, their population of origin, and their encoding functions. Assembly-based methods reduce dataset size by extending overlapping reads into larger contiguous sequences (contigs), providing contextual information for genetic sequences that does not rely on existing references. These methods, however, tend to be computationally intensive and are again challenged by sequencing errors as well as by genomic repeats While numerous tools have been developed based on these methodological concepts, they present confounding choices and training requirements to metagenomic investigators. To help with accessibility to assembly tools, this review also includes an IPython Notebook metagenomic assembly tutorial. This tutorial has instructions for execution any operating system using Amazon Elastic Cloud Compute and guides users through downloading, assembly, and mapping reads to contigs of a mock microbiome metagenome. Despite its challenges, metagenomic analysis has already revealed novel insights into many environments on Earth. As software, training, and data continue to emerge, metagenomic data access and its discoveries will to grow. PMID:26217314

  16. Challenges and opportunities in understanding microbial communities with metagenome assembly (accompanied by IPython Notebook tutorial

    Directory of Open Access Journals (Sweden)

    Adina eHowe

    2015-07-01

    Full Text Available Metagenomic investigations hold great promise for informing the genetics, physiology, and ecology of environmental microorganisms. Current challenges for metagenomic analysis are related to our ability to connect the dots between sequencing reads, their population of origin, and their encoding functions. Assembly-based methods reduce dataset size by extending overlapping reads into larger contiguous sequences (contigs, providing contextual information for genetic sequences that does not rely on existing references. These methods, however, tend to be computationally intensive and are again challenged by sequencing errors as well as by genomic repeats While numerous tools have been developed based on these methodological concepts, they present confounding choices and training requirements to metagenomic investigators. To help with accessibility to assembly tools, this review also includes an IPython Notebook metagenomic assembly tutorial. This tutorial has instructions for execution any operating system using Amazon Elastic Cloud Compute and guides users through downloading, assembly, and mapping reads to contigs of a mock microbiome metagenome. Despite its challenges, metagenomic analysis has already revealed novel insights into many environments on Earth. As software, training, and data continue to emerge, metagenomic data access and its discoveries will to grow.

  17. Global challenges in integrated coastal zone management

    DEFF Research Database (Denmark)

    integration of data and information in policy and management, combining expertise from nature and social science, to reach a balanced and sustainable development of the coastal zone. This important book comprises the proceedings of The International Symposium on Integrated Coastal Zone Management, which took....../mitigation to change in coastal systems Coastal governance Linking science and management Comprising a huge wealth of information, this timely and well-edited volume is essential reading for all those involved in coastal zone management around the globe. All libraries in research establishments and universities where...

  18. INTEGRATION OF SHIP HULL ASSEMBLY SEQUENCE PLANNING, SCHEDULING AND BUDGETING

    Directory of Open Access Journals (Sweden)

    Remigiusz Romuald Iwańkowicz

    2015-02-01

    Full Text Available The specificity of the yard work requires the particularly careful treatment of the issues of scheduling and budgeting in the production planning processes. The article presents the method of analysis of the assembly sequence taking into account the duration of individual activities and the demand for resources. A method of the critical path and resource budgeting were used. Modelling of the assembly was performed using the acyclic graphs. It has been shown that the assembly sequences can have very different feasible budget regions. The proposed model is applied to the assembly processes of large-scale welded structures, including the hulls of ships. The presented computational examples have a simulation character. They show the usefulness of the model and the possibility to use it in a variety of analyses.

  19. Regional Power Integration : Structural and Regulatory Challenges

    OpenAIRE

    World Bank

    2011-01-01

    The Central America Regional Electricity Market (MER) trades electricity and transmission capacity among six Central American countries: Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua and Panama. The market differs from other electricity markets worldwide because it has its own regulatory body and system operator. Economic integration of the Central American countries has followed...

  20. Challenges of knowledge integration in small and medium enterprises

    Directory of Open Access Journals (Sweden)

    Kavoos Mohannak

    2014-03-01

    Full Text Available This study attempts to develop a better understanding of the challenges of knowledge integration (KI within the innovation process in Small and Medium Enterprises (SMEs. Using several case studies, this study investigates how knowledge integration may be managed within the context of innovation in SMEs. The research places particular focus on identifying the challenges of knowledge integration in SMEs in relation to three aspects of knowledge integration activities, namely knowledge identification, knowledge acquisition, and knowledge sharing. Four distinct tasks emerged in the knowledge integration process, namely team building capability, capturing tacit knowledge, role of knowledge management (KM systems, and technological systemic integration. The paper suggests that managing knowledge integration in SMEs can be best managed by focusing on these four tasks, which in turn will lead to innovation.

  1. Curriculum integrated information literacy: a challenge

    DEFF Research Database (Denmark)

    Bønløkke, Mette; Kobow, Else; Kristensen, Anne-Kirstine Østergaard

    2012-01-01

    Information literacy is a competence needed for students and for practitioners in the nursing profession. A curriculum integrated intervention was qualitatively evaluated by focus group interviews of students, lecturers and the university librarian. Information literacy makes sense for students...... when it is linked to assignments, timed right, prepared, systematic and continuous. Support is needed to help students understand the meaning of seeking information, to focus their problem and to make them reflect on their search and its results. Feedback on materials used is also asked for...

  2. Challenges of Integrating Affordable and Sustainable Housing in Malaysia

    Science.gov (United States)

    Syed Jamaludin, S. Z. H.; Mahayuddin, S. A.; Hamid, S. H. A.

    2018-04-01

    Developing countries including Malaysia have begun to comprehend the needs for affordable and sustainable housing development. The majority of the population is still aspiring for a comfortable, safe and reasonably priced house. Households in the low-middle income range face difficulties to find housing that can satisfy their needs and budget. Unfortunately, most of the housing development programs are considering affordability rather than sustainable aspects. Furthermore, developers are more interested in profit and neglect sustainability issues. Thus, the aim of this paper is to review the challenges in integrating affordable housing and sustainable practices in Malaysia. This paper is produced based on an extensive literature review as a basis to develop strategies of integrated affordable and sustainable housing in Malaysia. The challenges are divided into four sections, namely market challenges, professional challenges, societal challenges and technological challenges. The outcomes of this paper will assist in the decision making involving housing development and in enhancing quality of life for sustainable communities.

  3. Human Resource Challenges to Integrating HIV Pre-Exposure ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    These challenges paralleled current challenges related to integration of antiretroviral therapy (ART) and ..... is not additional work but is rather another HIV ... should be added to performance contracts (terms of ... stress and burnout, difficulty adhering to time- ... Similarly, the role of ... (diploma level) nursing officers or clinical.

  4. THE BASIC PRINCIPLES OF THE INTEGRATED MANAGEMENT OF THE PROCESS OF ASSEMBLY AND THREADING

    Directory of Open Access Journals (Sweden)

    Anton Skorkin

    2017-11-01

    Full Text Available The subject matter of this article is the issues related to the integrated management of assembling operations of fastening and threading elements at all stages of their implementation. The goal is to develop the generalized structure of the data management system of the process of assembly and threading. The objectives are: to justify the principles of managing the assembly and threading process at each stage of the assembly to improve the efficiency of these operations, to study the power, accuracy and performance characteristics of the connections and to draw the conclusion that suggested the theory of assembly management is efficient. The following results are obtained. The article presents the analytical dependencies of the force indexes of threading in the course of the package and sheet assembly, including the tightening force while joining; the assembly of a multilayered package of dissimilar sheet materials was analyzed. On the basis of the theoretical analysis, the dependences of the power indices of threading during the package and sheet assembly were determined. The assembly of the package of sheet materials was investigated, including a multilayered package of dissimilar materials of a “metal-plastic” type. Conclusions. The process of assembling threaded joints with the use of management principles was used; these principles enable increasing the efficiency of the assembly process, reducing the complexity of the basic operations, and improving the quality of the joints obtained. The use adaptive control of the screwing speed on the main threading transitions is suggested for reducing the torque.  The technology of making threaded joints with given properties is developed, the main ways of increasing the efficiency of assembly and threading processes are determined on the basis of the integrated control system for the assembly process.

  5. Challenge of Effective Technology Integration into Teaching and Learning

    Science.gov (United States)

    Ramorola, M. Z.

    2013-01-01

    South African teachers are faced with challenges in integrating technology effectively into a coherent framework at school level. There seems to be little evidence of technology integration into classroom activities such as systematic planning and implementation of lessons that require learners to think critically, work collaboratively, and use…

  6. Integrating Test-Form Formatting into Automated Test Assembly

    Science.gov (United States)

    Diao, Qi; van der Linden, Wim J.

    2013-01-01

    Automated test assembly uses the methodology of mixed integer programming to select an optimal set of items from an item bank. Automated test-form generation uses the same methodology to optimally order the items and format the test form. From an optimization point of view, production of fully formatted test forms directly from the item pool using…

  7. Integrated Quality Control of Precision Assemblies using Computed Tomography

    DEFF Research Database (Denmark)

    Stolfi, Alessandro

    coor-dinate measuring machines (CMMs) when working with complex and fragile parts. This Ph.D. project at DTU Mechanical Engineering concerns the applicability of CT for quality control of precision assem-blies. Investigations to quantify the accuracy of CT measurements, reference artefacts to correct...

  8. Molecular Assemblies, Genes and Genomics Integrated Efficiently (MAGGIE)

    Energy Technology Data Exchange (ETDEWEB)

    Baliga, Nitin S

    2011-05-26

    Final report on MAGGIE. We set ambitious goals to model the functions of individual organisms and their community from molecular to systems scale. These scientific goals are driving the development of sophisticated algorithms to analyze large amounts of experimental measurements made using high throughput technologies to explain and predict how the environment influences biological function at multiple scales and how the microbial systems in turn modify the environment. By experimentally evaluating predictions made using these models we will test the degree to which our quantitative multiscale understanding wilt help to rationally steer individual microbes and their communities towards specific tasks. Towards this end we have made substantial progress towards understanding evolution of gene families, transcriptional structures, detailed structures of keystone molecular assemblies (proteins and complexes), protein interactions, biological networks, microbial interactions, and community structure. Using comparative analysis we have tracked the evolutionary history of gene functions to understand how novel functions evolve. One level up, we have used proteomics data, high-resolution genome tiling microarrays, and 5' RNA sequencing to revise genome annotations, discover new genes including ncRNAs, and map dynamically changing operon structures of five model organisms: For Desulfovibrio vulgaris Hildenborough, Pyrococcus furiosis, Sulfolobus solfataricus, Methanococcus maripaludis and Haiobacterium salinarum NROL We have developed machine learning algorithms to accurately identify protein interactions at a near-zero false positive rate from noisy data generated using tagfess complex purification, TAP purification, and analysis of membrane complexes. Combining other genome-scale datasets produced by ENIGMA (in particular, microarray data) and available from literature we have been able to achieve a true positive rate as high as 65% at almost zero false positives

  9. Westinghouse-DOE integration: Meeting the challenge

    International Nuclear Information System (INIS)

    Price, S.V.

    1992-01-01

    The Westinghouse Electric Corporation (WEC) is in a unique position to affect national environmental management policy approaching the 21st Century. Westinghouse companies are management and operating contractors (MOC,s) at several environmentally pivotal government-owned, contractor operated (GOCO) facilities within the Department of Energy's (DOE's) nuclear defense complex. One way the WEC brings its companies together is by activating teams to solve specific DOE site problems. For example, one challenging issue at DOE facilities involves the environmentally responsible, final disposal of transuranic and high-level nuclear wastes (TRUs and HLWS). To address these disposal issues, the DOE supports two Westinghouse-based task forces: The TRU Waste Acceptance Criteria Certification Committee (WACCC) and the HLW Vitrification Committee. The WACCC is developing methods to characterize an estimated 176,287 cubic meters of retrievably stored TRUs generated at DOE production sites. Once characterized, TRUs could be safely deposited in the WIPP repository. The Westinghouse HLW Vitrification Committee is dedicated to assess appropriate methods to process an estimated 380,702 cubic meters of HLWs currently stored in underground storage tanks (USTs). As planned, this processing will involve segregating, and appropriately treating, low level waste (LLW) and HLW tank constituents for eventual disposal. The first unit designed to process these nuclear wastes is the SRS Defense Waste Processing Facility (DWPF). Initiated in 1973, the DWPF project is scheduled to begin operations in 1991 or 1992. Westinghouse companies are also working together to achieve appropriate environmental site restoration at DOE sites via the GOCO Environmental Restoration Committee

  10. Cryogenic Fiber Optic Assemblies for Spaceflight Environments: Design, Manufacturing, Testing, and Integration

    Science.gov (United States)

    Thomes, W. Joe; Ott, Melanie N.; Chuska, Richard; Switzer, Robert; Onuma, Eleanya; Blair, Diana; Frese, Erich; Matyseck, Marc

    2016-01-01

    Fiber optic assemblies have been used on spaceflight missions for many years as an enabling technology for routing, transmitting, and detecting optical signals. Due to the overwhelming success of NASA in implementing fiber optic assemblies on spaceflight science-based instruments, system scientists increasingly request fibers that perform in extreme environments while still maintaining very high optical transmission, stability, and reliability. Many new applications require fiber optic assemblies that will operate down to cryogenic temperatures as low as 20 Kelvin. In order for the fiber assemblies to operate with little loss in optical throughput at these extreme temperatures requires a system level approach all the way from how the fiber assembly is manufactured to how it is held, routed, and integrated. The NASA Goddard Code 562 Photonics Group has been designing, manufacturing, testing, and integrating fiber optics for spaceflight and other high reliability applications for nearly 20 years. Design techniques and lessons learned over the years are consistently applied to developing new fiber optic assemblies that meet these demanding environments. System level trades, fiber assembly design methods, manufacturing, testing, and integration will be discussed. Specific recent examples of ground support equipment for the James Webb Space Telescope (JWST); the Ice, Cloud and Land Elevation Satellite-2 (ICESat-2); and others will be included.

  11. A participatory and integrative approach to improve productivity and ergonomics in assembly

    NARCIS (Netherlands)

    Looze, M.P. de; Rhijn, J.W. van; Deursen, J. van; Tuinzaad, G.H.; Reijneveld, C.N.

    2003-01-01

    A participatory and integrative approach was applied to improve the productivity and ergonomics of the assembly lines in two factories, producing magnetic stop valves and office furniture, respectively. Main elements of the approach are the active participation of the company and the integration of

  12. De novo assembly of Phlomis purpurea after challenging with Phytophthora cinnamomi.

    Science.gov (United States)

    Baldé, Aladje; Neves, Dina; García-Breijo, Francisco J; Pais, Maria Salomé; Cravador, Alfredo

    2017-09-06

    Phlomis plants are a source of biological active substances with potential applications in the control of phytopathogens. Phlomis purpurea (Lamiaceae) is autochthonous of southern Iberian Peninsula and Morocco and was found to be resistant to Phytophthora cinnamomi. Phlomis purpurea has revealed antagonistic effect in the rhizosphere of Quercus suber and Q. ilex against P. cinnamomi. Phlomis purpurea roots produce bioactive compounds exhibiting antitumor and anti-Phytophthora activities with potential to protect susceptible plants. Although these important capacities of P. purpurea have been demonstrated, there is no transcriptomic or genomic information available in public databases that could bring insights on the genes underlying this anti-oomycete activity. Using Illumina technology we obtained a de novo assembly of P. purpurea transcriptome and differential transcript abundance to identify putative defence related genes in challenged versus non-challenged plants. A total of 1,272,600,000 reads from 18 cDNA libraries were merged and assembled into 215,739 transcript contigs. BLASTX alignment to Nr NCBI database identified 124,386 unique annotated transcripts (57.7%) with significant hits. Functional annotation identified 83,550 out of 124,386 unique transcripts, which were mapped to 141 pathways. 39% of unigenes were assigned GO terms. Their functions cover biological processes, cellular component and molecular functions. Genes associated with response to stimuli, cellular and primary metabolic processes, catalytic and transporter functions were among those identified. Differential transcript abundance analysis using DESeq revealed significant differences among libraries depending on post-challenge times. Comparative cyto-histological studies of P. purpurea roots challenged with P. cinnamomi zoospores and controls revealed specific morphological features (exodermal strips and epi-cuticular layer), that may provide a constitutive efficient barrier against

  13. Integrating DNA strand-displacement circuitry with DNA tile self-assembly

    Science.gov (United States)

    Zhang, David Yu; Hariadi, Rizal F.; Choi, Harry M.T.; Winfree, Erik

    2013-01-01

    DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures. PMID:23756381

  14. Self-Esteem Challenges of Nursing Students: An Integrative Review

    OpenAIRE

    KEOGH, BRIAN

    2016-01-01

    Introduction: Self-esteem among nursing students is important in providing high-quality serviceto clients, yet each study in this field has described only a portion of existing relevant knowledge.Integrative review studies are the best practice for identification of existing nursing knowledge.The purpose of this study was to determine self-esteem challenges among nursing students. Methods: An integrative review was conducted in this study. The databases ProQuest, Medlineon PubMed, Science Dir...

  15. The design and analysis of integral assembly experiments for CTR neutronics

    International Nuclear Information System (INIS)

    Beynon, T.D.; Curtis, R.H.; Lambert, C.

    1978-01-01

    The use of simple-geometry integral assemblies of lithium metal or lithium compounds for the study of the neutronics of various CTR designs is considered and four recent experiments are analysed. The relatively long mean free path of neutrons in these assemblies produces significantly different design problems from those encountered in similar experiments for fission reactor design. By considering sensitivity profiles for various parameters it is suggested that experiments can be designed to be optimised for data adjustments. (author)

  16. Grand challenges for integrated USGS science—A workshop report

    Science.gov (United States)

    Jenni, Karen E.; Goldhaber, Martin B.; Betancourt, Julio L.; Baron, Jill S.; Bristol, R. Sky; Cantrill, Mary; Exter, Paul E.; Focazio, Michael J.; Haines, John W.; Hay, Lauren E.; Hsu, Leslie; Labson, Victor F.; Lafferty, Kevin D.; Ludwig, Kristin A.; Milly, Paul C. D.; Morelli, Toni L.; Morman, Suzette A.; Nassar, Nedal T.; Newman, Timothy R.; Ostroff, Andrea C.; Read, Jordan S.; Reed, Sasha C.; Shapiro, Carl D.; Smith, Richard A.; Sanford, Ward E.; Sohl, Terry L.; Stets, Edward G.; Terando, Adam J.; Tillitt, Donald E.; Tischler, Michael A.; Toccalino, Patricia L.; Wald, David J.; Waldrop, Mark P.; Wein, Anne; Weltzin, Jake F.; Zimmerman, Christian E.

    2017-06-30

    Executive SummaryThe U.S. Geological Survey (USGS) has a long history of advancing the traditional Earth science disciplines and identifying opportunities to integrate USGS science across disciplines to address complex societal problems. The USGS science strategy for 2007–2017 laid out key challenges in disciplinary and interdisciplinary arenas, culminating in a call for increased focus on a number of crosscutting science directions. Ten years on, to further the goal of integrated science and at the request of the Executive Leadership Team (ELT), a workshop with three dozen invited scientists spanning different disciplines and career stages in the Bureau convened on February 7–10, 2017, at the USGS John Wesley Powell Center for Analysis and Synthesis in Fort Collins, Colorado.The workshop focused on identifying “grand challenges” for integrated USGS science. Individual participants identified nearly 70 potential grand challenges before the workshop and through workshop discussions. After discussion, four overarching grand challenges emerged:Natural resource security,Societal risk from existing and emerging threats,Smart infrastructure development, andAnticipatory science for changing landscapes.Participants also identified a “comprehensive science challenge” that highlights the development of integrative science, data, models, and tools—all interacting in a modular framework—that can be used to address these and other future grand challenges:Earth Monitoring, Analyses, and Projections (EarthMAP)EarthMAP is our long-term vision for an integrated scientific framework that spans traditional scientific boundaries and disciplines, and integrates the full portfolio of USGS science: research, monitoring, assessment, analysis, and information delivery.The Department of Interior, and the Nation in general, have a vast array of information needs. The USGS meets these needs by having a broadly trained and agile scientific workforce. Encouraging and supporting

  17. CasEMBLR: Cas9-Facilitated Multiloci Genomic Integration of in Vivo Assembled DNA Parts in Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Jakociunas, Tadas; Rajkumar, Arun Stephen; Zhang, Jie

    2015-01-01

    , we present a method for marker-free multiloci integration of in vivo assembled DNA parts. By the use of CRISPR/Cas9-mediated one-step double-strand breaks at single, double and triple integration sites we report the successful in vivo assembly and chromosomal integration of DNA parts. We call our...

  18. SIMULTANEOUS INTEGRATION OF WATER AND ENERGY: ACHIEVEMENTS AND CHALLENGES

    Directory of Open Access Journals (Sweden)

    Junior Lorenzo Llanes

    2016-01-01

    Full Text Available Process Integration (PI is a tool that for over forty years has demonstrated its strength to provide optimal solutions to complex problems. The interaction of exchange systems of energy and water networks is a typical case of such problems. The gradual increase in the consumption of water and energy has determined the development of methodologies that take into account the simultaneous integration of these resources. This paper aims to present a literature review related to the simultaneous integration of water and energy. First, general items related to this research field are presented, emphasizing the approaches to simultaneous integration (Pinch Analysis and Mathematical Programming. Some recent cases of studies, demonstrating the strength of these tools mainly focus to sugar industry, are also presented. Finally some of the challenges to be faced by the simultaneous integration of water and energy for the diversification of the Cuban sugar industry are presented.

  19. Integrating community assembly and biodiversity to better understand ecosystem function: the Community Assembly and the Functioning of Ecosystems (CAFE) approach.

    Science.gov (United States)

    Bannar-Martin, Katherine H; Kremer, Colin T; Ernest, S K Morgan; Leibold, Mathew A; Auge, Harald; Chase, Jonathan; Declerck, Steven A J; Eisenhauer, Nico; Harpole, Stanley; Hillebrand, Helmut; Isbell, Forest; Koffel, Thomas; Larsen, Stefano; Narwani, Anita; Petermann, Jana S; Roscher, Christiane; Cabral, Juliano Sarmento; Supp, Sarah R

    2018-02-01

    The research of a generation of ecologists was catalysed by the recognition that the number and identity of species in communities influences the functioning of ecosystems. The relationship between biodiversity and ecosystem functioning (BEF) is most often examined by controlling species richness and randomising community composition. In natural systems, biodiversity changes are often part of a bigger community assembly dynamic. Therefore, focusing on community assembly and the functioning of ecosystems (CAFE), by integrating both species richness and composition through species gains, losses and changes in abundance, will better reveal how community changes affect ecosystem function. We synthesise the BEF and CAFE perspectives using an ecological application of the Price equation, which partitions the contributions of richness and composition to function. Using empirical examples, we show how the CAFE approach reveals important contributions of composition to function. These examples show how changes in species richness and composition driven by environmental perturbations can work in concert or antagonistically to influence ecosystem function. Considering how communities change in an integrative fashion, rather than focusing on one axis of community structure at a time, will improve our ability to anticipate and predict changes in ecosystem function. © 2017 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

  20. Nondestructive Assay Data Integration with the SKB-50 Assemblies - FY16 Update

    International Nuclear Information System (INIS)

    Tobin, Stephen Joseph; Fugate, Michael Lynn; Trellue, Holly Renee; DeBaere, Paul; Sjoland, Anders; Liljenfeldt, Henrik; Hu, Jianwei; Backstrom, Ulrika; Bengtsson, Martin; Burr, Tomas; Eliasson, Annika; Favalli, Andrea; Gauld, Ian; Grogan, Brandon; Jansson, Peter; Junell, Henrik; Schwalbach, Peter; Vaccaro, Stefano; Vo, Duc Ta; Wildestrand, Henrik

    2016-01-01

    A project to research the application of non-destructive assay (NDA) techniques for spent fuel assemblies is underway at the Central Interim Storage Facility for Spent Nuclear Fuel (for which the Swedish acronym is Clab) in Oskarshamn, Sweden. The research goals of this project contain both safeguards and non-safeguards interests. These nondestructive assay (NDA) technologies are designed to strengthen the technical toolkit of safeguard inspectors and others to determine the following technical goals more accurately; Verify initial enrichment, burnup, and cooling time of facility declaration for spent fuel assemblies; Detect replaced or missing pins from a given spent fuel assembly to confirm its integrity; and Estimate plutonium mass and related plutonium and uranium fissile mass parameters in spent fuel assemblies. Estimate heat content, and measure reactivity (multiplication).

  1. Integrating succession and community assembly perspectives [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Cynthia Chang

    2016-09-01

    Full Text Available Succession and community assembly research overlap in many respects, such as through their focus on how ecological processes like dispersal, environmental filters, and biotic interactions influence community structure. Indeed, many recent advances have been made by successional studies that draw on modern analytical techniques introduced by contemporary community assembly studies. However, community assembly studies generally lack a temporal perspective, both on how the forces structuring communities might change over time and on how historical contingency (e.g. priority effects and legacy effects and complex transitions (e.g. threshold effects might alter community trajectories. We believe a full understanding of the complex interacting processes that shape community dynamics across large temporal scales can best be achieved by combining concepts, tools, and study systems into an integrated conceptual framework that draws upon both succession and community assembly theory.

  2. Nondestructive Assay Data Integration with the SKB-50 Assemblies - FY16 Update

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, Stephen Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fugate, Michael Lynn [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Trellue, Holly Renee [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); DeBaere, Paul [DG Energy, Luxembourg (Germany); Sjoland, Anders [Swedish Nuclear Fuel and Waste Management Company, Stockholm (Sweden); Liljenfeldt, Henrik [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hu, Jianwei [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Backstrom, Ulrika [Swedish Nuclear Fuel and Waste Management Company, Stockholm (Sweden); Vattenfall AB, Stockholm (Sweden); Bengtsson, Martin [Swedish Nuclear Fuel and Waste Management Company, Stockholm (Sweden); Vattenfall AB, Stockholm (Sweden); Burr, Tomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); International Atomic Energy Agency, Vienna (Austria); Eliasson, Annika [Swedish Nuclear Fuel and Waste Management Company, Stockholm (Sweden); Favalli, Andrea [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gauld, Ian [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Grogan, Brandon [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jansson, Peter [Uppsala Univ. (Sweden); Junell, Henrik [Swedish Nuclear Fuel and Waste Management Company, Stockholm (Sweden); Schwalbach, Peter [DG Energy, Luxembourg (Germany); Vaccaro, Stefano [DG Energy, Luxembourg (Germany); Vo, Duc Ta [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Wildestrand, Henrik [Swedish Nuclear Fuel and Waste Management Company, Stockholm (Sweden); Vattenfall AB, Stockholm (Sweden)

    2016-10-28

    A project to research the application of non-destructive assay (NDA) techniques for spent fuel assemblies is underway at the Central Interim Storage Facility for Spent Nuclear Fuel (for which the Swedish acronym is Clab) in Oskarshamn, Sweden. The research goals of this project contain both safeguards and non-safeguards interests. These nondestructive assay (NDA) technologies are designed to strengthen the technical toolkit of safeguard inspectors and others to determine the following technical goals more accurately; Verify initial enrichment, burnup, and cooling time of facility declaration for spent fuel assemblies; Detect replaced or missing pins from a given spent fuel assembly to confirm its integrity; and Estimate plutonium mass and related plutonium and uranium fissile mass parameters in spent fuel assemblies. Estimate heat content, and measure reactivity (multiplication).

  3. Challenges and Approach for Making the Top End Optical Assembly for the 4-meter Advanced Technology Solar Telescope

    Science.gov (United States)

    Canzian, Blaise; Barentine, J.; Hull, T.

    2012-01-01

    L-3 Integrated Optical Systems (IOS) Division has been selected by the National Solar Observatory (NSO) to make the Top End Optical Assembly (TEOA) for the 4-meter Advanced Technology Solar Telescope (ATST) to operate at Haleakala, Maui. ATST will perform to a very high optical performance level in a difficult thermal environment. The TEOA, containing the 0.65-meter silicon carbide secondary mirror and support, mirror thermal management system, mirror positioning and fast tip-tilt system, field stop with thermally managed heat dump, thermally managed Lyot stop, safety interlock and control system, and support frame, operates in the "hot spot” at the prime focus of the ATST and so presents special challenges. In this paper, we will describe the L-3 IOS technical approach to meet these challenges, including subsystems for opto-mechanical positioning, rejected and stray light control, wavefront tip-tilt compensation, and thermal management. Key words: ATST, TEOA, L-3 IOS, thermal management, silicon carbide (SiC) mirrors, hexapods, solar astronomy

  4. European Socio-Economic Integration Challenges, Opportunities and Lessons Learned

    CERN Document Server

    Korres, George

    2013-01-01

    Economic integration is one of the most noteworthy issues in international economic policy at the end of the twentieth century. The recent examples of the European Union (EU) and the North American Free Trade Association (NAFTA) have raised important questions about the economic integration process and the possible establishment of economic unions in other parts of the world.  Against the backdrop of the financial crisis in Europe and prospects of increasing integration in Asia, this volume showcases research from an international array of researchers to provide a basic understanding of the current issues, problems, challenges, and opportunities for achieving integration, addressing both empirical and theoretical aspects of such topics as monetary union, social policy reform and social union, public finance and technology policy.  The chapters in Part 1 are focused primarily on economic issues, while Part 2 covers on social policy, the welfare state, and political reforms, with a particular emphasis on the ...

  5. Assembly and Multiplex Genome Integration of Metabolic Pathways in Yeast Using CasEMBLR

    DEFF Research Database (Denmark)

    Jakočiūnas, Tadas; Jensen, Emil D.; Jensen, Michael Krogh

    2018-01-01

    and marker-free integration of the carotenoid pathway from 15 exogenously supplied DNA parts into three targeted genomic loci. As a second proof-of-principle, a total of ten DNA parts were assembled and integrated in two genomic loci to construct a tyrosine production strain, and at the same time knocking......Genome integration is a vital step for implementing large biochemical pathways to build a stable microbial cell factory. Although traditional strain construction strategies are well established for the model organism Saccharomyces cerevisiae, recent advances in CRISPR/Cas9-mediated genome...... engineering allow much higher throughput and robustness in terms of strain construction. In this chapter, we describe CasEMBLR, a highly efficient and marker-free genome engineering method for one-step integration of in vivo assembled expression cassettes in multiple genomic sites simultaneously. Cas...

  6. Integrating an Academic Electronic Health Record: Challenges and Success Strategies.

    Science.gov (United States)

    Herbert, Valerie M; Connors, Helen

    2016-08-01

    Technology is increasing the complexity in the role of today's nurse. Healthcare organizations are integrating more health information technologies and relying on the electronic health record for data collection, communication, and decision making. Nursing faculty need to prepare graduates for this environment and incorporate an academic electronic health record into a nursing curriculum to meet student-program outcomes. Although the need exists for student preparation, some nursing programs are struggling with implementation, whereas others have been successful. To better understand these complexities, this project was intended to identify current challenges and success strategies of effective academic electronic health record integration into nursing curricula. Using Rogers' 1962 Diffusion of Innovation theory as a framework for technology adoption, a descriptive survey design was used to gain insights from deans and program directors of nursing schools involved with the national Health Informatics & Technology Scholars faculty development program or Cerner's Academic Education Solution Consortium, working to integrate an academic electronic health record in their respective nursing schools. The participants' experiences highlighted approaches used by these schools to integrate these technologies. Data from this project provide nursing education with effective strategies and potential challenges that should be addressed for successful academic electronic health record integration.

  7. The Modern Hearing Aid – an Extreme System Integration Challenge

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Harald Holger

    (Application Specific Integrated Circuit) to produce a competitive advantage in terms of size and features. This presentation will give a brief insight into the hearing aid market and industry and a brief view of the historic development of hearing aids. The system integration challenge will be illustrated......People with reduced hearing generally want to hide this disability and thus the size of hearing aids is constantly decreasing in the effort to make them virtually invisible. However, as for all other modern electrical devices more and more features are constantly added to hearing aids driven...

  8. Challenges and opportunities in integration of design and control

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted

    2015-01-01

    Process synthesis and design of plant operation are related topics but current industrial practice solves these problems sequentially. The implication of this sequential strategy may result in design of processing systems which are very hard to control. This paper presents a discussion on drivers...... for an integrated approach and outlines the challenges in formulation of such a multi-objective synthesis problem. This discussion is viewed in relation to some of the changing trends in the industry. Significant results have been published which in different ways seek to handle the integrated problem. Further...

  9. Employee health services integration: meeting the challenge. Successful program.

    Science.gov (United States)

    Lang, Y C

    1998-02-01

    1. The first step of a successful Employee Health Service integration is to have a plan supported by management. The plan must be presented to the employees prior to implementation in a "user friendly" manner. 2. Prior to computerization of employee health records, a record order system must be developed to prevent duplication and to enhance organization. 3. Consistency of services offered must be maintained. Each employee must have the opportunity to receive the same service. Complexity of services will determine the site of delivery. 4. Integration is a new and challenging development for the health care field. Flexibility and brainstorming are necessary in an attempt to meet both employee and employer needs.

  10. Barriers and Challenges in the Integrated Design Process Approcach

    DEFF Research Database (Denmark)

    Knudstrup, Mary-Ann

    2006-01-01

    ABSTRACT: In the future, it will be a huge challenge to make sustainable building design by using a more holistic and innovative approach in order to be able to decrease or reduce the use of energy for heating and cooling in new building projects. This is seen in the perspective of the Kyoto agre....... It also describes the barriers and the challenges that must be overcome when trying to cross the borders between the two fields of engineering and architecture to design sustainable architecture....... agreement for reducing the global heating. This paper will briefly present the method of the Integrated Design Process, IDP [1]. It describes the background and means for developing a new method for designing integrated architecture in an interdisciplinary approach between architecture and engineering...

  11. Challenges and options for large scale integration of wind power

    International Nuclear Information System (INIS)

    Tande, John Olav Giaever

    2006-01-01

    Challenges and options for large scale integration of wind power are examined. Immediate challenges are related to weak grids. Assessment of system stability requires numerical simulation. Models are being developed - validation is essential. Coordination of wind and hydro generation is a key for allowing more wind power capacity in areas with limited transmission corridors. For the case study grid depending on technology and control the allowed wind farm size is increased from 50 to 200 MW. The real life example from 8 January 2005 demonstrates that existing marked based mechanisms can handle large amounts of wind power. In wind integration studies it is essential to take account of the controllability of modern wind farms, the power system flexibility and the smoothing effect of geographically dispersed wind farms. Modern wind farms contribute to system adequacy - combining wind and hydro constitutes a win-win system (ml)

  12. Integration of renewables. Status and challenges in China

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, Kat

    2011-08-12

    This Working Paper gives an overview of the status and challenges of integrating an increasing share of variable renewables in China, with a focus on areas of generation, power transmission, demand-side management and policy. Some of these areas are intertwined with the nature and design of China's electricity power market and pricing mechanism, which have an impact on the effectiveness of the country's targets to accommodate larger shares of renewables.

  13. Assembly and Multiplex Genome Integration of Metabolic Pathways in Yeast Using CasEMBLR.

    Science.gov (United States)

    Jakočiūnas, Tadas; Jensen, Emil D; Jensen, Michael K; Keasling, Jay D

    2018-01-01

    Genome integration is a vital step for implementing large biochemical pathways to build a stable microbial cell factory. Although traditional strain construction strategies are well established for the model organism Saccharomyces cerevisiae, recent advances in CRISPR/Cas9-mediated genome engineering allow much higher throughput and robustness in terms of strain construction. In this chapter, we describe CasEMBLR, a highly efficient and marker-free genome engineering method for one-step integration of in vivo assembled expression cassettes in multiple genomic sites simultaneously. CasEMBLR capitalizes on the CRISPR/Cas9 technology to generate double-strand breaks in genomic loci, thus prompting native homologous recombination (HR) machinery to integrate exogenously derived homology templates. As proof-of-principle for microbial cell factory development, CasEMBLR was used for one-step assembly and marker-free integration of the carotenoid pathway from 15 exogenously supplied DNA parts into three targeted genomic loci. As a second proof-of-principle, a total of ten DNA parts were assembled and integrated in two genomic loci to construct a tyrosine production strain, and at the same time knocking out two genes. This new method complements and improves the field of genome engineering in S. cerevisiae by providing a more flexible platform for rapid and precise strain building.

  14. Integrity Evaluation of Control Rod Assembly for Sodium-Cooled Fast Reactor due to Drop Impact

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyun Seung; Yoon, Kyung Ho; Kim, Hyung Kyu; Cheon, Jin Sik; Lee, Chan Bock [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2017-03-15

    The CA (Control Assembly) of an SFR has a CRA(Control Rod Assembly) with an inner duct and control rod. During an emergency situation, the CRA falls into the duct of the CA for a rapid shut-down. The drop time and impact velocity of the CRA are important parameters with respect to the reactivity insertion time and the structural integrity of the CRA. The objective of this study was to investigate the dynamic behavior and integrity of the CRA owing to a drop impact. The impact analysis of the CRA under normal/abnormal drop conditions was carried out using the commercial FEM code LS-DYNA. Results of the drop impact analysis demonstrated that the CRA maintained structural integrity, and could be safely inserted into the flow hole of the damper under abnormal conditions.

  15. Integrity Evaluation of Control Rod Assembly for Sodium-Cooled Fast Reactor due to Drop Impact

    International Nuclear Information System (INIS)

    Lee, Hyun Seung; Yoon, Kyung Ho; Kim, Hyung Kyu; Cheon, Jin Sik; Lee, Chan Bock

    2017-01-01

    The CA (Control Assembly) of an SFR has a CRA(Control Rod Assembly) with an inner duct and control rod. During an emergency situation, the CRA falls into the duct of the CA for a rapid shut-down. The drop time and impact velocity of the CRA are important parameters with respect to the reactivity insertion time and the structural integrity of the CRA. The objective of this study was to investigate the dynamic behavior and integrity of the CRA owing to a drop impact. The impact analysis of the CRA under normal/abnormal drop conditions was carried out using the commercial FEM code LS-DYNA. Results of the drop impact analysis demonstrated that the CRA maintained structural integrity, and could be safely inserted into the flow hole of the damper under abnormal conditions.

  16. Structural integrity assessment and stress measurement of CHASNUPP-1 fuel assembly

    Directory of Open Access Journals (Sweden)

    Waseem

    2016-01-01

    Full Text Available Fuel assembly of the PWR nuclear power plant is a long and flexible structure. This study has been made in an attempt to find the structural integrity of the fuel assembly (FA of Chashma Nuclear Power Plant-1 (CHASNUPP-1 at room temperature in air. The non-linear contact and structural tensile analysis have been performed using ANSYS 13.0, in order to determine the fuel assembly (FA elongation behaviour as well as the location and values of the stress intensity and stresses developed in axial direction under applied tensile load of 9800 N or 2 g being the fuel assembly handling or lifting load [Y. Zhang et al., Fuel assembly design report, SNERDI, China, 1994]. The finite element (FE model comprises spacer grids, fuel rods, flexible contacts between the fuel rods and grid's supports system and guide thimbles with dash-pots and flow holes, in addition to the spot welds between spacer grids and guide thimbles, has been developed using Shell181, Conta174 and Targe170 elements. FA is a non-straight structure. The actual behavior of the geometry is non-linear due to its curvature or design tolerance. It has been observed that fuel assembly elongation values obtained through FE analysis and experiment [SNERDI Tech. Doc., Mechanical strength and calculation for fuel assembly, Technical Report, F3.2.1, China, 1994] under applied tensile load are comparable and show approximately linear behaviors. Therefore, it seems that the permanent elongation of fuel assembly may not occur at the specified load. Moreover, the values of stresses obtained at different locations of the fuel assembly are also comparable with the stress values of the experiment determined at the same locations through strain gauges. Since the results of both studies (analytical and experimental are comparable, therefore, validation of the FE methodology is confirmed. The stress intensity of the FE model and maximum stresses developed along the guide thimbles in axial direction are

  17. New faces of porous Prussian blue: interfacial assembly of integrated hetero-structures for sensing applications.

    Science.gov (United States)

    Kong, Biao; Selomulya, Cordelia; Zheng, Gengfeng; Zhao, Dongyuan

    2015-11-21

    Prussian blue (PB), the oldest synthetic coordination compound, is a classic and fascinating transition metal coordination material. Prussian blue is based on a three-dimensional (3-D) cubic polymeric porous network consisting of alternating ferric and ferrous ions, which provides facile assembly as well as precise interaction with active sites at functional interfaces. A fundamental understanding of the assembly mechanism of PB hetero-interfaces is essential to enable the full potential applications of PB crystals, including chemical sensing, catalysis, gas storage, drug delivery and electronic displays. Developing controlled assembly methods towards functionally integrated hetero-interfaces with adjustable sizes and morphology of PB crystals is necessary. A key point in the functional interface and device integration of PB nanocrystals is the fabrication of hetero-interfaces in a well-defined and oriented fashion on given substrates. This review will bring together these key aspects of the hetero-interfaces of PB nanocrystals, ranging from structure and properties, interfacial assembly strategies, to integrated hetero-structures for diverse sensing.

  18. Component design challenges for the ground-based SP-100 nuclear assembly test

    International Nuclear Information System (INIS)

    Markley, R.A.; Disney, R.K.; Brown, G.B.

    1989-01-01

    The SP-100 ground engineering system (GES) program involves a ground test of the nuclear subsystems to demonstrate their design. The GES nuclear assembly test (NAT) will be performed in a simulated space environment within a vessel maintained at ultrahigh vacuum. The NAT employs a radiation shielding system that is comprised of both prototypical and nonprototypical shield subsystems to attenuate the reactor radiation leakage and also nonprototypical heat transport subsystems to remove the heat generated by the reactor. The reactor is cooled by liquid lithium, which will operate at temperatures prototypical of the flight system. In designing the components for these systems, a number of design challenges were encountered in meeting the operational requirements of the simulated space environment (and where necessary, prototypical requirements) while also accommodating the restrictions of a ground-based test facility with its limited available space. This paper presents a discussion of the design challenges associated with the radiation shield subsystem components and key components of the heat transport systems

  19. Compliant heterogeneous assemblies of micro-VCSELs as a new materials platform for integrated optoelectronics

    Science.gov (United States)

    Kang, Dongseok; Lee, Sung-Min; Kwong, Anthony; Yoon, Jongseung

    2015-03-01

    Despite many unique advantages, vertical cavity surface emitting lasers (VCSELs) have been available mostly on rigid, planar wafers over restricted areas, thereby limiting their usage for applications that can benefit from large-scale, programmable assemblies, hybrid integration with dissimilar materials and devices, or mechanically flexible constructions. Here, materials design and fabrication strategies that address these limitations of conventional VCSELs are presented. Specialized design of epitaxial materials and etching processes, together with printing-based deterministic assemblies and substrate thermal engineering, enabled defect-free release of microscale VCSELs and their device- and circuit-level implementation on non-native, flexible substrates with performance comparable to devices on the growth substrate.

  20. Self-Esteem Challenges of Nursing Students: An Integrative Review

    Directory of Open Access Journals (Sweden)

    Leila Valizadeh

    2016-06-01

    Full Text Available Introduction: Self-esteem among nursing students is important in providing high-quality serviceto clients, yet each study in this field has described only a portion of existing relevant knowledge.Integrative review studies are the best practice for identification of existing nursing knowledge.The purpose of this study was to determine self-esteem challenges among nursing students. Methods: An integrative review was conducted in this study. The databases ProQuest, Medlineon PubMed, Science Direct, Google Scholar and Iran Medix were used for the review. The articleswere retrieved in three steps, including searching by search terms, reviewing the proceedingsbased on inclusion criteria and final retrieval and assessment of the available full texts. We used alist of keywords, including nursing, self-esteem and challenges and mixed them with "AND" and"OR" as a search strategy. Papers were included and eligible if they were associated with problemsrelated to nursing students’ self-esteem. Those studies that focused only on the self-esteem ofregistered nurses or patients were excluded. Search results were limited to the years 1960-2014. Results: Our findings showed three major challenges, including challenges associated withinconsistency in determining the level of students’ self-esteem, self-esteem associated challengesin professionalism of students, and the psychosocial challenges pertaining to the consequences oflow self-esteem. Conclusion: The findings suggest there is a need for more qualitative research to explore thefactors that contribute to self-esteem in nursing students with a particular focus on the factorsthat increase or decrease self-esteem. In addition, strategies to maintain and increase self-esteemneed to be designed, implemented and evaluated.

  1. Integrated Radiation Transport and Nuclear Fuel Performance for Assembly-Level Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Clarno, Kevin T [ORNL; Hamilton, Steven P [ORNL; Philip, Bobby [ORNL; Berrill, Mark A [ORNL; Sampath, Rahul S [ORNL; Allu, Srikanth [ORNL; Pugmire, Dave [ORNL; Dilts, Gary [Los Alamos National Laboratory (LANL); Banfield, James E [ORNL

    2012-02-01

    The Advanced Multi-Physics (AMP) Nuclear Fuel Performance code (AMPFuel) is focused on predicting the temperature and strain within a nuclear fuel assembly to evaluate the performance and safety of existing and advanced nuclear fuel bundles within existing and advanced nuclear reactors. AMPFuel was extended to include an integrated nuclear fuel assembly capability for (one-way) coupled radiation transport and nuclear fuel assembly thermo-mechanics. This capability is the initial step toward incorporating an improved predictive nuclear fuel assembly modeling capability to accurately account for source-terms and boundary conditions of traditional (single-pin) nuclear fuel performance simulation, such as the neutron flux distribution, coolant conditions, and assembly mechanical stresses. A novel scheme is introduced for transferring the power distribution from the Scale/Denovo (Denovo) radiation transport code (structured, Cartesian mesh with smeared materials within each cell) to AMPFuel (unstructured, hexagonal mesh with a single material within each cell), allowing the use of a relatively coarse spatial mesh (10 million elements) for the radiation transport and a fine spatial mesh (3.3 billion elements) for thermo-mechanics with very little loss of accuracy. In addition, a new nuclear fuel-specific preconditioner was developed to account for the high aspect ratio of each fuel pin (12 feet axially, but 1 4 inches in diameter) with many individual fuel regions (pellets). With this novel capability, AMPFuel was used to model an entire 17 17 pressurized water reactor fuel assembly with many of the features resolved in three dimensions (for thermo-mechanics and/or neutronics), including the fuel, gap, and cladding of each of the 264 fuel pins; the 25 guide tubes; the top and bottom structural regions; and the upper and lower (neutron) reflector regions. The final, full assembly calculation was executed on Jaguar using 40,000 cores in under 10 hours to model over 162

  2. Characterization of the Caliban and Prospero Critical Assemblies Neutron Spectra for Integral Measurements Experiments

    Science.gov (United States)

    Casoli, P.; Authier, N.; Jacquet, X.; Cartier, J.

    2014-04-01

    Caliban and Prospero are two highly enriched uranium metallic core reactors operated on the CEA Center of Valduc. These critical assemblies are suitable for integral experiments, such as fission yields measurements or perturbation measurements, which have been carried out recently on the Caliban reactor. Different unfolding methods, based on activation foils and fission chambers measurements, are used to characterize the reactor spectra and especially the Caliban spectrum, which is very close to a pure fission spectrum.

  3. Integral measurements on Caliban and Prospero assemblies for nuclear data validation

    International Nuclear Information System (INIS)

    Casoli, P.; Authier, N.; Richard, B.; Ducauze-Philippe, M.; Cartier, J.

    2011-01-01

    How can the quality of nuclear data libraries be checked? Performing reference experiments also called benchmarks allows the testing of evaluated data. During these experiments, integral values such as reaction rates or neutron effective multiplication coefficients are measured. In this paper, the principles of benchmark construction are explained and illustrated with several works performed on the CALIBAN et PROSPERO critical assemblies operated by the Valduc center: benchmarks for dosimetry, activation reactions studies, neutron noise measurements. (authors)

  4. Integration of Self-Assembled Microvascular Networks with Microfabricated PEG-Based Hydrogels.

    Science.gov (United States)

    Cuchiara, Michael P; Gould, Daniel J; McHale, Melissa K; Dickinson, Mary E; West, Jennifer L

    2012-11-07

    Despite tremendous efforts, tissue engineered constructs are restricted to thin, simple tissues sustained only by diffusion. The most significant barrier in tissue engineering is insufficient vascularization to deliver nutrients and metabolites during development in vitro and to facilitate rapid vascular integration in vivo. Tissue engineered constructs can be greatly improved by developing perfusable microvascular networks in vitro in order to provide transport that mimics native vascular organization and function. Here a microfluidic hydrogel is integrated with a self-assembling pro-vasculogenic co-culture in a strategy to perfuse microvascular networks in vitro. This approach allows for control over microvascular network self-assembly and employs an anastomotic interface for integration of self-assembled micro-vascular networks with fabricated microchannels. As a result, transport within the system shifts from simple diffusion to vessel supported convective transport and extra-vessel diffusion, thus improving overall mass transport properties. This work impacts the development of perfusable prevascularized tissues in vitro and ultimately tissue engineering applications in vivo.

  5. Challenges of Integrated Water Resources Management in Indonesia

    Directory of Open Access Journals (Sweden)

    Mohamad Ali Fulazzaky

    2014-07-01

    Full Text Available The increased demands for water and land in Indonesia as a consequence of the population growth and economic development has reportedly have been accelerated from the year to year. The spatial and temporal variability of human induced hydrological changes in a river basin could affect quality and quantity of water. The challenge is that integrated water resources management (IWRM should cope with complex issues of water in order to maximize the resultant economic and social welfare in an equitable manner, without compromising the sustainability of vital ecosystems. Even though the government of Indonesia has adopted new paradigm for water resources management by the enactment of Law No. 7/2004 on water resources, the implementation of IWRM may face the technical and managerial challenges. This paper briefly reviews the implementation of IWRM and related principles and provides an overview of potential water-related issues and progress towards implementation of IWRM in Indonesia. The availability of water and a broader range of water-related issues are identified. The recommended actions for improving the future IWRM are suggested. Challenges to improve the capacity buildings of IWRM related to enabling environment, institutional frameworks and management instruments are verified to contribute to the future directions for efficient problem-solving ability.

  6. The challenge of integrating evidence-based design.

    Science.gov (United States)

    Martin, Caren S

    2009-01-01

    This paper discusses the integration of evidence-based design (EBD) into the design process as an innovation, illuminates the significance and progress of the diffusion of this innovation, and identifies EBD advocates and the consequences of meeting the EBD challenge. A free tool for engaging in EBD is explored. Healthcare designers are leading the EBD charge, because their clients depend on it. But not all designers engage in EBD, because it may be beyond the resources of a firm or outside its culture. However, as with other meaningful design innovations, designers who do not practice EBD could fall by the wayside. EBD is a product of the diffusion of the innovation of evidence-based medicine. The academy (i.e., the collective of institutions of higher education), design organizations, design communities, and the media all contribute to the diffusion of EBD. However, the quantity, quality, and understandability of evidence continue to challenge its broad adoption. InformeDesign®, a free, Internet-based tool, presents information to designers in a concise, understandable way. Firms must invest in EBD incrementally as a value-added component of design to meet current and future challenges. It is important for designers to realize that engaging in EBD is not a rejection of creativity, but a means by which to elevate their design solutions. ©2009 VENDOME GROUP, LLC

  7. Integrative self-assembly of functional hybrid nanoconstructs by inorganic wrapping of single biomolecules, biomolecule arrays and organic supramolecular assemblies.

    Science.gov (United States)

    Patil, Avinash J; Li, Mei; Mann, Stephen

    2013-08-21

    Synthesis of functional hybrid nanoscale objects has been a core focus of the rapidly progressing field of nanomaterials science. In particular, there has been significant interest in the integration of evolutionally optimized biological systems such as proteins, DNA, virus particles and cells with functional inorganic building blocks to construct mesoscopic architectures and nanostructured materials. However, in many cases the fragile nature of the biomolecules seriously constrains their potential applications. As a consequence, there is an on-going quest for the development of novel strategies to modulate the thermal and chemical stabilities, and performance of biomolecules under adverse conditions. This feature article highlights new methods of "inorganic molecular wrapping" of single or multiple protein molecules, individual double-stranded DNA helices, lipid bilayer vesicles and self-assembled organic dye superstructures using inorganic building blocks to produce bio-inorganic nanoconstructs with core-shell type structures. We show that spatial isolation of the functional biological nanostructures as "armour-plated" enzyme molecules or polynucleotide strands not only maintains their intact structure and biochemical properties, but also enables the fabrication of novel hybrid nanomaterials for potential applications in diverse areas of bionanotechnology.

  8. Integrative self-assembly of functional hybrid nanoconstructs by inorganic wrapping of single biomolecules, biomolecule arrays and organic supramolecular assemblies

    Science.gov (United States)

    Patil, Avinash J.; Li, Mei; Mann, Stephen

    2013-07-01

    Synthesis of functional hybrid nanoscale objects has been a core focus of the rapidly progressing field of nanomaterials science. In particular, there has been significant interest in the integration of evolutionally optimized biological systems such as proteins, DNA, virus particles and cells with functional inorganic building blocks to construct mesoscopic architectures and nanostructured materials. However, in many cases the fragile nature of the biomolecules seriously constrains their potential applications. As a consequence, there is an on-going quest for the development of novel strategies to modulate the thermal and chemical stabilities, and performance of biomolecules under adverse conditions. This feature article highlights new methods of ``inorganic molecular wrapping'' of single or multiple protein molecules, individual double-stranded DNA helices, lipid bilayer vesicles and self-assembled organic dye superstructures using inorganic building blocks to produce bio-inorganic nanoconstructs with core-shell type structures. We show that spatial isolation of the functional biological nanostructures as ``armour-plated'' enzyme molecules or polynucleotide strands not only maintains their intact structure and biochemical properties, but also enables the fabrication of novel hybrid nanomaterials for potential applications in diverse areas of bionanotechnology.

  9. Integrated groundwater management: An overview of concepts and challenges

    Science.gov (United States)

    Jakeman, Anthony J.; Barreteau, Olivier; Hunt, Randall J.; Rinaudo, Jean-Daniel; Ross, Andrew; Jakeman, Anthony J.; Barreteau, Olivier; Hunt, Randall J.; Rinaudo, Jean-Daniel; Ross, Andrew

    2016-01-01

    Managing water is a grand challenge problem and has become one of humanity’s foremost priorities. Surface water resources are typically societally managed and relatively well understood; groundwater resources, however, are often hidden and more difficult to conceptualize. Replenishment rates of groundwater cannot match past and current rates of depletion in many parts of the world. In addition, declining quality of the remaining groundwater commonly cannot support all agricultural, industrial and urban demands and ecosystem functioning, especially in the developed world. In the developing world, it can fail to even meet essential human needs. The issue is: how do we manage this crucial resource in an acceptable way, one that considers the sustainability of the resource for future generations and the socioeconomic and environmental impacts? In many cases this means restoring aquifers of concern to some sustainable equilibrium over a negotiated period of time, and seeking opportunities for better managing groundwater conjunctively with surface water and other resource uses. However, there are many, often-interrelated, dimensions to managing groundwater effectively. Effective groundwater management is underpinned by sound science (biophysical and social) that actively engages the wider community and relevant stakeholders in the decision making process. Generally, an integrated approach will mean “thinking beyond the aquifer”, a view which considers the wider context of surface water links, catchment management and cross-sectoral issues with economics, energy, climate, agriculture and the environment. The aim of the book is to document for the first time the dimensions and requirements of sound integrated groundwater management (IGM). The primary focus is on groundwater management within its system, but integrates linkages beyond the aquifer. The book provides an encompassing synthesis for researchers, practitioners and water resource managers on the concepts and

  10. Optimization of Two-Level Disassembly/Remanufacturing/Assembly System with an Integrated Maintenance Strategy

    Directory of Open Access Journals (Sweden)

    Zouhour Guiras

    2018-04-01

    Full Text Available With an increase of environmental pressure on economic activities, reverse flow is increasingly important. It seeks to save resources, eliminate waste, and improve productivity. This paper investigates the optimization of the disassembly, remanufacturing and assembly system, taking into account assembly-disassembly system degradation. An analytical model is developed to consider disassembly, remanufacturing of used/end-of-life product and assembly of the finished product. The finished product is composed of remanufactured and new components. A maintenance policy is sequentially integrated to reduce the system unavailability. The aim of this study is to help decision-makers, under certain conditions, choose the most cost-effective process for them to satisfy the customer as well as to adapt to the potential risk that can perturb the disassembly-assembly system. A heuristic is developed to determine the optimal ordered date of the used end-of-life product as well as the optimum release dates of new external components. The results reveal that considering some remanufacturing and purchase components costs, the proposed model is more economical in comparison with a model without remanufactured parts. Numerical results are provided to illustrate the impact of the variation of the ordering cost and quality of the used end-of-life product on the system profitability. Finally, the risk due to system repair periods is discussed, which has an impact on managerial decision-making.

  11. Sequential induction of three recombination directionality factors directs assembly of tripartite integrative and conjugative elements.

    Directory of Open Access Journals (Sweden)

    Timothy L Haskett

    2018-03-01

    Full Text Available Tripartite integrative and conjugative elements (ICE3 are a novel form of ICE that exist as three separate DNA regions integrated within the genomes of Mesorhizobium spp. Prior to conjugative transfer the three ICE3 regions of M. ciceri WSM1271 ICEMcSym1271 combine and excise to form a single circular element. This assembly requires three coordinated recombination events involving three site-specific recombinases IntS, IntG and IntM. Here, we demonstrate that three excisionases-or recombination directionality factors-RdfS, RdfG and RdfM are required for ICE3 excision. Transcriptome sequencing revealed that expression of ICE3 transfer and conjugation genes was induced by quorum sensing. Quorum sensing activated expression of rdfS, and in turn RdfS stimulated transcription of both rdfG and rdfM. Therefore, RdfS acts as a "master controller" of ICE3 assembly and excision. The dependence of all three excisive reactions on RdfS ensures that ICE3 excision occurs via a stepwise sequence of recombination events that avoids splitting the chromosome into a non-viable configuration. These discoveries expose a surprisingly simple control system guiding molecular assembly of these novel and complex mobile genetic elements and highlight the diverse and critical functions of excisionase proteins in control of horizontal gene transfer.

  12. Sequential induction of three recombination directionality factors directs assembly of tripartite integrative and conjugative elements.

    Science.gov (United States)

    Haskett, Timothy L; Terpolilli, Jason J; Ramachandran, Vinoy K; Verdonk, Callum J; Poole, Phillip S; O'Hara, Graham W; Ramsay, Joshua P

    2018-03-01

    Tripartite integrative and conjugative elements (ICE3) are a novel form of ICE that exist as three separate DNA regions integrated within the genomes of Mesorhizobium spp. Prior to conjugative transfer the three ICE3 regions of M. ciceri WSM1271 ICEMcSym1271 combine and excise to form a single circular element. This assembly requires three coordinated recombination events involving three site-specific recombinases IntS, IntG and IntM. Here, we demonstrate that three excisionases-or recombination directionality factors-RdfS, RdfG and RdfM are required for ICE3 excision. Transcriptome sequencing revealed that expression of ICE3 transfer and conjugation genes was induced by quorum sensing. Quorum sensing activated expression of rdfS, and in turn RdfS stimulated transcription of both rdfG and rdfM. Therefore, RdfS acts as a "master controller" of ICE3 assembly and excision. The dependence of all three excisive reactions on RdfS ensures that ICE3 excision occurs via a stepwise sequence of recombination events that avoids splitting the chromosome into a non-viable configuration. These discoveries expose a surprisingly simple control system guiding molecular assembly of these novel and complex mobile genetic elements and highlight the diverse and critical functions of excisionase proteins in control of horizontal gene transfer.

  13. Integrated deterministic and probabilistic safety assessment: Concepts, challenges, research directions

    International Nuclear Information System (INIS)

    Zio, Enrico

    2014-01-01

    Highlights: • IDPSA contributes to robust risk-informed decision making in nuclear safety. • IDPSA considers time-dependent interactions among component failures and system process. • Also, IDPSA considers time-dependent interactions among control and operator actions. • Computational efficiency by advanced Monte Carlo and meta-modelling simulations. • Efficient post-processing of IDPSA output by clustering and data mining. - Abstract: Integrated deterministic and probabilistic safety assessment (IDPSA) is conceived as a way to analyze the evolution of accident scenarios in complex dynamic systems, like nuclear, aerospace and process ones, accounting for the mutual interactions between the failure and recovery of system components, the evolving physical processes, the control and operator actions, the software and firmware. In spite of the potential offered by IDPSA, several challenges need to be effectively addressed for its development and practical deployment. In this paper, we give an overview of these and discuss the related implications in terms of research perspectives

  14. Integrated deterministic and probabilistic safety assessment: Concepts, challenges, research directions

    Energy Technology Data Exchange (ETDEWEB)

    Zio, Enrico, E-mail: enrico.zio@ecp.fr [Ecole Centrale Paris and Supelec, Chair on System Science and the Energetic Challenge, European Foundation for New Energy – Electricite de France (EDF), Grande Voie des Vignes, 92295 Chatenay-Malabry Cedex (France); Dipartimento di Energia, Politecnico di Milano, Via Ponzio 34/3, 20133 Milano (Italy)

    2014-12-15

    Highlights: • IDPSA contributes to robust risk-informed decision making in nuclear safety. • IDPSA considers time-dependent interactions among component failures and system process. • Also, IDPSA considers time-dependent interactions among control and operator actions. • Computational efficiency by advanced Monte Carlo and meta-modelling simulations. • Efficient post-processing of IDPSA output by clustering and data mining. - Abstract: Integrated deterministic and probabilistic safety assessment (IDPSA) is conceived as a way to analyze the evolution of accident scenarios in complex dynamic systems, like nuclear, aerospace and process ones, accounting for the mutual interactions between the failure and recovery of system components, the evolving physical processes, the control and operator actions, the software and firmware. In spite of the potential offered by IDPSA, several challenges need to be effectively addressed for its development and practical deployment. In this paper, we give an overview of these and discuss the related implications in terms of research perspectives.

  15. Assembly and Integration Process of the First High Density Detector Array for the Atacama Cosmology Telescope

    Science.gov (United States)

    Li, Yaqiong; Choi, Steve; Ho, Shuay-Pwu; Crowley, Kevin T.; Salatino, Maria; Simon, Sara M.; Staggs, Suzanne T.; Nati, Federico; Wollack, Edward J.

    2016-01-01

    The Advanced ACTPol (AdvACT) upgrade on the Atacama Cosmology Telescope (ACT) consists of multichroicTransition Edge Sensor (TES) detector arrays to measure the Cosmic Microwave Background (CMB) polarization anisotropies in multiple frequency bands. The first AdvACT detector array, sensitive to both 150 and 230 GHz, is fabricated on a 150 mm diameter wafer and read out with a completely different scheme compared to ACTPol. Approximately 2000 TES bolometers are packed into the wafer leading to both a much denser detector density and readout circuitry. The demonstration of the assembly and integration of the AdvACT arrays is important for the next generation CMB experiments, which will continue to increase the pixel number and density. We present the detailed assembly process of the first AdvACT detector array.

  16. Investigation of properties of novel silicon pixel assemblies employing thin n-in-p sensors and 3D-integration

    International Nuclear Information System (INIS)

    Weigell, Philipp

    2013-01-01

    Until the end of the 2020 decade the LHC programme will be defining the high energy frontier of particle physics. During this time, three upgrade steps of the accelerator are currently planned to further increase the luminosity and energy reach. In the course of these upgrades the specifications of several parts of the current LHC detectors will be exceeded. Especially, the innermost tracking detectors are challenged by the increasing track densities and the radiation damage. This thesis focuses on the implications for the ATLAS experiment. Here, around 2021/2, after having collected an integrated luminosity of around 300 fb -1 , the silicon and gas detector components of the inner tracker will reach the end of their lifetime and will need to be replaced to ensure sufficient performance for continued running - especially if the luminosity is raised to about 5 x 10 35 cm -2 s -1 as currently planned. An all silicon inner detector is foreseen to be installed. This upgrade demands cost effective pixel assemblies with a minimal material budget, a larger active area fraction as compared to the current detectors, and a higher granularity. Furthermore, the assemblies must be able to withstand received fluences up to 2 . 10 16 n eq /cm 2 . A new pixel assembly concept answering the challenges posed by the high instantaneous luminosities is investigated in this thesis. It employs five novel technologies, namely n-in-p pixel sensors, thin pixel sensors, slim edges with or without implanted sensor sides, and 3D-integration incorporating a new interconnection technology, named Solid Liquid InterDiffusion (SLID) as well as Inter-Chip-Vias (ICVs). n-in-p sensors are cost-effective, since they only need patterned processing on one side. Their performance before and after irradiation is investigated and compared to results obtained with currently used n-in-n sensors. Reducing the thickness of the sensors lowers the amount of multiple scattering within the tracking system and leads

  17. Investigation of properties of novel silicon pixel assemblies employing thin n-in-p sensors and 3D-integration

    Energy Technology Data Exchange (ETDEWEB)

    Weigell, Philipp

    2013-01-15

    Until the end of the 2020 decade the LHC programme will be defining the high energy frontier of particle physics. During this time, three upgrade steps of the accelerator are currently planned to further increase the luminosity and energy reach. In the course of these upgrades the specifications of several parts of the current LHC detectors will be exceeded. Especially, the innermost tracking detectors are challenged by the increasing track densities and the radiation damage. This thesis focuses on the implications for the ATLAS experiment. Here, around 2021/2, after having collected an integrated luminosity of around 300 fb{sup -1}, the silicon and gas detector components of the inner tracker will reach the end of their lifetime and will need to be replaced to ensure sufficient performance for continued running - especially if the luminosity is raised to about 5 x 10{sup 35} cm{sup -2}s{sup -1} as currently planned. An all silicon inner detector is foreseen to be installed. This upgrade demands cost effective pixel assemblies with a minimal material budget, a larger active area fraction as compared to the current detectors, and a higher granularity. Furthermore, the assemblies must be able to withstand received fluences up to 2 . 10{sup 16} n{sub eq}/cm{sup 2}. A new pixel assembly concept answering the challenges posed by the high instantaneous luminosities is investigated in this thesis. It employs five novel technologies, namely n-in-p pixel sensors, thin pixel sensors, slim edges with or without implanted sensor sides, and 3D-integration incorporating a new interconnection technology, named Solid Liquid InterDiffusion (SLID) as well as Inter-Chip-Vias (ICVs). n-in-p sensors are cost-effective, since they only need patterned processing on one side. Their performance before and after irradiation is investigated and compared to results obtained with currently used n-in-n sensors. Reducing the thickness of the sensors lowers the amount of multiple scattering

  18. Design of an integral missile shield in integrated head assembly for pressurized water reactor at commercial nuclear plants

    International Nuclear Information System (INIS)

    Baliga, Ravi; Watts, Tom Neal; Kamath, Harish

    2015-01-01

    In ICONE22, the authors presented the Integrated Head Assembly (IHA) design concept implemented at Callaway Nuclear Power Plant in Missouri, USA. The IHA concept is implemented to reduce the outage duration and the associated radiation exposure to the workers by reducing critical path time during Plant Refueling Outage. One of the head area components in the IHA is a steel missile shield designed to protect the Control Rod Drive Mechanism (CRDM) assembly from damaging other safety-related components in the vicinity in the Containment. Per Federally implemented General Design Criteria for commercial nuclear plants in the USA, the design of Nuclear Steam Supply System (NSSS) must provide protection from the damages caused by a postulated event of CRDM housing units and their associated parts disengaging from the reactor vessel assembly. This event is considered as a Loss of Coolant Accident (LOCA) and assumes that once the CRDM housing unit and their associated parts disengage from the reactor vessel internals assembly, they travel upward by the water jet with the following sequence of events: Per Reference 1, the drive shaft and control rod cluster are forced out of the reactor core by the differential pressure across the drive shaft with the assumption that the drive shaft and control rod cluster, latched together, are fully inserted when the accident occurs. After the travel, the rod cluster control spider will impact the lower side of the upper support plate inside the reactor vessel fracturing the flexure arms in the joint freeing the drive shaft from the control rod cluster. The control rod cluster is stopped by the upper support plate and will remain below the upper support plate during this accident. However, the drive shaft will continue to accelerate in the upward direction until it is stopped by a safety feature in the IHA. The integral missile shield as a safety feature in the IHA is designed to stop the CRDM drive shaft from moving further up in the

  19. Challenges and opportunities for integrating lake ecosystem modelling approaches

    Science.gov (United States)

    Mooij, Wolf M.; Trolle, Dennis; Jeppesen, Erik; Arhonditsis, George; Belolipetsky, Pavel V.; Chitamwebwa, Deonatus B.R.; Degermendzhy, Andrey G.; DeAngelis, Donald L.; Domis, Lisette N. De Senerpont; Downing, Andrea S.; Elliott, J. Alex; Ruberto, Carlos Ruberto; Gaedke, Ursula; Genova, Svetlana N.; Gulati, Ramesh D.; Hakanson, Lars; Hamilton, David P.; Hipsey, Matthew R.; Hoen, Jochem 't; Hulsmann, Stephan; Los, F. Hans; Makler-Pick, Vardit; Petzoldt, Thomas; Prokopkin, Igor G.; Rinke, Karsten; Schep, Sebastiaan A.; Tominaga, Koji; Van Dam, Anne A.; Van Nes, Egbert H.; Wells, Scott A.; Janse, Jan H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and trait-based models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative

  20. Challenges in graphene integration for high-frequency electronics

    Science.gov (United States)

    Giannazzo, F.; Fisichella, G.; Greco, G.; Roccaforte, F.

    2016-06-01

    This paper provides an overview of the state-of-the-art research on graphene (Gr) for high-frequency (RF) devices. After discussing current limitations of lateral Gr RF transistors, novel vertical devices concepts such as the Gr Base Hot Electron Transistor (GBHET) will be introduced and the main challenges in Gr integration within these architectures will be discussed. In particular, a GBHET device based on Gr/AlGaN/GaN heterostructure will be considered. An approach to the fabrication of this heterostructure by transfer of CVD grown Gr on copper to the AlGaN surface will be presented. The morphological and electrical properties of this system have been investigated at nanoscale by atomic force microscopy (AFM) and conductive atomic force microscopy (CAFM). In particular, local current-voltage measurements by the CAFM probe revealed the formation of a Schottky contact with low barrier height (˜0.41 eV) and excellent lateral uniformity between Gr and AlGaN. Basing on the electrical parameters extracted from this characterization, the theoretical performances of a GBHET formed by a metal/Al2O3/Gr/AlGaN/GaN stack have been evaluated.

  1. Raman laser spectrometer optical head: qualification model assembly and integration verification

    Science.gov (United States)

    Ramos, G.; Sanz-Palomino, M.; Moral, A. G.; Canora, C. P.; Belenguer, T.; Canchal, R.; Prieto, J. A. R.; Santiago, A.; Gordillo, C.; Escribano, D.; Lopez-Reyes, G.; Rull, F.

    2017-08-01

    Raman Laser Spectrometer (RLS) is the Pasteur Payload instrument of the ExoMars mission, within the ESA's Aurora Exploration Programme, that will perform for the first time in an out planetary mission Raman spectroscopy. RLS is composed by SPU (Spectrometer Unit), iOH (Internal Optical Head), and ICEU (Instrument Control and Excitation Unit). iOH focuses the excitation laser on the samples (excitation path), and collects the Raman emission from the sample (collection path, composed on collimation system and filtering system). Its original design presented a high laser trace reaching to the detector, and although a certain level of laser trace was required for calibration purposes, the high level degrades the Signal to Noise Ratio confounding some Raman peaks. So, after the bread board campaign, some light design modifications were implemented in order to fix the desired amount of laser trace, and after the fabrication and the commitment of the commercial elements, the assembly and integration verification process was carried out. A brief description of the iOH design update for the engineering and qualification model (iOH EQM) as well as the assembly process are briefly described in this papers. In addition, the integration verification and the first functional tests, carried out with the RLS calibration target (CT), results are reported on.

  2. Titanium dioxide nanowire sensor array integration on CMOS platform using deterministic assembly.

    Science.gov (United States)

    Gall, Oren Z; Zhong, Xiahua; Schulman, Daniel S; Kang, Myungkoo; Razavieh, Ali; Mayer, Theresa S

    2017-06-30

    Nanosensor arrays have recently received significant attention due to their utility in a wide range of applications, including gas sensing, fuel cells, internet of things, and portable health monitoring systems. Less attention has been given to the production of sensor platforms in the μW range for ultra-low power applications. Here, we discuss how to scale the nanosensor energy demand by developing a process for integration of nanowire sensing arrays on a monolithic CMOS chip. This work demonstrates an off-chip nanowire fabrication method; subsequently nanowires link to a fused SiO 2 substrate using electric-field assisted directed assembly. The nanowire resistances shown in this work have the highest resistance uniformity reported to date of 18%, which enables a practical roadmap towards the coupling of nanosensors to CMOS circuits and signal processing systems. The article also presents the utility of optimizing annealing conditions of the off-chip metal-oxides prior to CMOS integration to avoid limitations of thermal budget and process incompatibility. In the context of the platform demonstrated here, directed assembly is a powerful tool that can realize highly uniform, cross-reactive arrays of different types of metal-oxide nanosensors suited for gas discrimination and signal processing systems.

  3. Integration of micro nano and bio technologies with layer-by-layer self-assembly

    Science.gov (United States)

    Kommireddy, Dinesh Shankar

    In the past decade, layer-by-layer (LbL) nanoassembly has been used as a tool for immobilization and surface modification of materials with applications in biology and physical sciences. Often, in such applications, LbL assembly is integrated with various techniques to form functional surface coatings and immobilized matrices. In this work, integration of LbL with microfabrication and microfluidics, and tissue engineering are explored. In an effort to integrate microfabrication with LbL nanoassembly, microchannels were fabricated using soft-lithography and the surface of these channels was used for the immobilization of materials using LbL and laminar flow patterning. Synthesis of poly(dimethyldiallyl ammonium chloride)/poly(styrene sulfonate) and poly(dimethyldiallyl ammonium chloride)/bovine serum albumin microstrips is demonstrated with the laminar flow microfluidic reactor. Resulting micropatterns are 8-10 mum wide, separated with few micron gaps. The width of these microstrips as well as their position in the microchannel is controlled by varying the flow rate, time of interaction and concentration of the individual components, which is verified by numerical simulation. Spatially resolved pH sensitivity was observed by modifying the surface of the channel with a pH sensitive dye. In order to investigate the integration of LbL assembly with tissue engineering, glass substrates were coated with nanoparticle/polyelectrolyte layers, and two different cell types were used to test the applicability of these coatings for the surface modification of medical implants. Titanium dioxide (TiO 2), silicon dioxide, halloysite and montmorillonite nanoparticles were assembled with oppositely charged polyelectrolytes. In-vitro cytotoxicity tests of the nanoparticle substrates on human dermal firbroblasts (HDFs) showed that the nanoparticle surfaces do not have toxic effects on the cells. HDFs retained their phenotype on the nanoparticle coatings, by synthesizing type

  4. Comparison of Normalized and Unnormalized Single Cell and Population Assemblies (MICW - Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Hugenholtz, Phil

    2011-10-12

    University of Queensland's Phil Hugenholtz on "Comparison of Normalized and Unnormalized Single Cell and Population Assemblies" at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  5. Regional Economic Integration in Africa: Challenges and Prospects ...

    African Journals Online (AJOL)

    Africa has witnessed various efforts of economic integration at the continental and regional levels. While the idea of regional integration is as old as the Organization of African Unity now renamed as African Union, recent summits have reaffirmed Africa's commitment toward boosting intra-Africa trade and integration. With the ...

  6. Structural integrity of rod cluster control assembly of Chashma Nuclear Power Plant -1

    International Nuclear Information System (INIS)

    Siddiqui, A.; Zafar, F.; Murtaza, G.

    2008-01-01

    This study has been made in an attempt to verify the structural integrity of Rod Cluster Control Assembly (RCCA) of Chashma Nuclear Power Plant-1(CHASNUPP-1) using ANSYS computer code. The CHASNUPP-1 (PWR type, 300 MWe capacity, unit 1) was built by China at Chashma (District Mianwali), Pakistan. The plant is successfully operating since 2000. The rod cluster control assemblies (RCCA) are used to control fast reactivity changes in PWR type reactors during the normal operation and accident conditions. To fulfill this function the RCCA is stepped upwards or downwards by control rod drive mechanism (CRDM). The stepping action produces a large amount of acceleration. The load produced during stepping is normally considered as limiting one. In this work we have considered the experimental results of a test conducted in China. The test was performed to measure the acceleration produced in upward and downward stepping by CRDM on RCCA, at room temperatures, both in air and static water. The test results showed acceleration (g, m/s 2 ) values, 10.8 - 51.0 and 46.4 - 78.0, in air and static water environments, respectively. Making the analysis on conservative side we selected the highest value of acceleration, 78 g, for our study. To ensure the structural strength, a finite element model of CHASNUPP-1 RCCA has been developed simulating the loading conditions prevailing during reactor operation. This model has been analyzed using the Finite Element Code. The Maximum Stress intensity obtained through this analysis, 186 MPa, is less than the yield stress of RCCA material (∼SS 321), 205 MPa, thus fulfills its structural integrity criteria. (authors)

  7. Engineering within the assembly, verification, and integration (AIV) process in ALMA

    Science.gov (United States)

    Lopez, Bernhard; McMullin, Joseph P.; Whyborn, Nicholas D.; Duvall, Eugene

    2010-07-01

    The Atacama Large Millimeter/submillimeter Array (ALMA) is a joint project between astronomical organizations in Europe, North America, and East Asia, in collaboration with the Republic of Chile. ALMA will consist of at least 54 twelve-meter antennas and 12 seven-meter antennas operating as an interferometer in the millimeter and sub-millimeter wavelength range. It will be located at an altitude above 5000m in the Chilean Atacama desert. As part of the ALMA construction phase the Assembly, Verification and Integration (AIV) team receives antennas and instrumentation from Integrated Product Teams (IPTs), verifies that the sub-systems perform as expected, performs the assembly and integration of the scientific instrumentation and verifies that functional and performance requirements are met. This paper aims to describe those aspects related to the AIV Engineering team, its role within the 4-station AIV process, the different phases the group underwent, lessons learned and potential space for improvement. AIV Engineering initially focused on the preparation of the necessary site infrastructure for AIV activities, on the purchase of tools and equipment and on the first ALMA system installations. With the first antennas arriving on site the team started to gather experience with AIV Station 1 beacon holography measurements for the assessment of the overall antenna surface quality, and with optical pointing to confirm the antenna pointing and tracking capabilities. With the arrival of the first receiver AIV Station 2 was developed which focuses on the installation of electrical and cryogenic systems and incrementally establishes the full connectivity of the antenna as an observing platform. Further antenna deliveries then allowed to refine the related procedures, develop staff expertise and to transition towards a more routine production process. Stations 3 and 4 deal with verification of the antenna with integrated electronics by the AIV Science Team and is not covered

  8. Investigation of Properties of Novel Silicon Pixel Assemblies Employing Thin n-in-p Sensors and 3D-Integration

    CERN Document Server

    Weigell, Philipp

    Until the end of the 2020 decade the LHC programme will be defining the high energy frontier of particle physics. During this time, three upgrade steps of the accelerator are currently planned to further increase the luminosity and energy reach. In the course of these upgrades the specifications of several parts of the current LHC detectors will be exceeded. Especially, the innermost tracking detectors are challenged by the increasing track densities and the radiation damage. This thesis focuses on the implications for the ATLAS experiment. Here, around 2021/2, after having collected an integrated luminosity of around 300/fb¹ , the silicon and gas detector components of the inner tracker will reach the end of their lifetime and will need to be replaced to ensure sufficient performance for continued running|especially if the luminosity is raised to about 5x10^35/(cm²s¹ ) as currently planned. An all silicon inner detector is foreseen to be installed. This upgrade demands cost-effective pixel assemblies with...

  9. From NGS assembly challenges to instability of fungal mitochondrial genomes: A case study in genome complexity.

    Science.gov (United States)

    Misas, Elizabeth; Muñoz, José Fernando; Gallo, Juan Esteban; McEwen, Juan Guillermo; Clay, Oliver Keatinge

    2016-04-01

    The presence of repetitive or non-unique DNA persisting over sizable regions of a eukaryotic genome can hinder the genome's successful de novo assembly from short reads: ambiguities in assigning genome locations to the non-unique subsequences can result in premature termination of contigs and thus overfragmented assemblies. Fungal mitochondrial (mtDNA) genomes are compact (typically less than 100 kb), yet often contain short non-unique sequences that can be shown to impede their successful de novo assembly in silico. Such repeats can also confuse processes in the cell in vivo. A well-studied example is ectopic (out-of-register, illegitimate) recombination associated with repeat pairs, which can lead to deletion of functionally important genes that are located between the repeats. Repeats that remain conserved over micro- or macroevolutionary timescales despite such risks may indicate functionally or structurally (e.g., for replication) important regions. This principle could form the basis of a mining strategy for accelerating discovery of function in genome sequences. We present here our screening of a sample of 11 fully sequenced fungal mitochondrial genomes by observing where exact k-mer repeats occurred several times; initial analyses motivated us to focus on 17-mers occurring more than three times. Based on the diverse repeats we observe, we propose that such screening may serve as an efficient expedient for gaining a rapid but representative first insight into the repeat landscapes of sparsely characterized mitochondrial chromosomes. Our matching of the flagged repeats to previously reported regions of interest supports the idea that systems of persisting, non-trivial repeats in genomes can often highlight features meriting further attention. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. W(h)ither the Oracle? Cognitive biases and other human challenges of integrated environmental modeling

    Science.gov (United States)

    Glynn, Pierre D.; Ames, D.P.; Quinn, N. W. T.; Rizzoli, A.E.

    2014-01-01

    Integrated environmental modeling (IEM) can organize and increase our knowledge of the complex, dynamic ecosystems that house our natural resources and control the quality of our environments. Human behavior, however, must be taken into account. Human biases/heuristics reflect adaptation over our evolutionary past to frequently experienced situations that affected our survival and that provided sharply distinguished feedbacks at the level of the individual. Unfortunately, human behavior is not adapted to the more diffusely experienced, less frequently encountered, problems and issues that IEM typically seeks to address in the simulation of natural resources and environments. While seeking inspiration from the prophetic traditions of the Oracle of Delphi, several human biases are identified that may affect how the science base of IEM is assembled, and how IEM results are interpreted and used. These biases are supported by personal observations, and by the findings of behavioral scientists. A process for critical analysis is proposed that solicits explicit accounting and cognizance of potential human biases. A number of suggestions are made to address the human challenges of IEM, in addition to maintaining attitudes of watchful humility, open-mindedness, honesty, and transparent accountability. These include creating a new area of study in the behavioral biogeosciences, using structured processes for engaging the modeling and stakeholder community in IEM, and using “red teams” to increase resilience of IEM constructs and use.

  11. Integrating Social Science and Ecosystem Management: A National Challenge

    Science.gov (United States)

    Cordell; H. Ken; Linda Caldwell

    1995-01-01

    These proceedings contain the contributed papers and panel presentations, as well as a paper presented at the National Workshop, of the Conference on Integrating Social Sciences and Ecosystem Management, which was held at Unicoi Lodge and Conference Center, Helen, GA, December 12-14, 1995. The overall purpose of this Conference was to improve understanding, integration...

  12. Integrative research on environmental and landscape change: PhD students' motivations and challenges.

    Science.gov (United States)

    Tress, Bärbel; Tress, Gunther; Fry, Gary

    2009-07-01

    The growing demand for integrative (interdisciplinary or transdisciplinary) approaches in the field of environmental and landscape change has increased the number of PhD students working in this area. Yet, the motivations to join integrative projects and the challenges for PhD students have so far not been investigated. The aims of this paper were to identify the understanding of PhD students with regard to integrative research, their motivations to join integrative projects, their expectations in terms of integration and results, and to reveal the challenges they face in integrative projects. We collected data by a questionnaire survey of 104 PhD students attending five PhD Master Classes held from 2003 to 2006. We used manual content analysis to analyse the free-text answers. The results revealed that students lack a differentiated understanding of integrative approaches. The main motivations to join integrative projects were the dissertation subject, the practical relevance of the project, the intellectual stimulation of working with different disciplines, and the belief that integrative research is more innovative. Expectations in terms of integration were high. Core challenges for integration included intellectual and external challenges such as lack of knowledge of other disciplines, knowledge transfer, reaching depth, supervision, lack of exchange with other students and time demands. To improve the situation for PhD students, we suggest improving knowledge on integrative approaches, balancing practical applicability with theoretical advancement, providing formal introductions to other fields of research, and enhancing institutional support for integrative PhD projects.

  13. The challenge of integrating large scale wind power

    Energy Technology Data Exchange (ETDEWEB)

    Kryszak, B.

    2007-07-01

    The support of renewable energy sources is one of the key issues in current energy policies. The paper presents aspects of the integration of wind power in the electric power system from the perspective of a Transmission System Operator (TSO). Technical, operational and market aspects related to the integration of more than 8000 MW of installed wind power into the Transmission Network of Vattenfall Europe Transmission are discussed, and experiences with the transmission of wind power, wind power prediction, balancing of wind power, power production behaviour and fluctuations are reported. Moreover, issues for wind power integration on a European level will be discussed with the background of a wind power study. (auth)

  14. An Integrated Picture of Star Formation, Metallicity Evolution, and Galactic Stellar Mass Assembly

    Science.gov (United States)

    Cowie, L. L.; Barger, A. J.

    2008-10-01

    We present an integrated study of star formation and galactic stellar mass assembly from z = 0.05 to 1.5 and galactic metallicity evolution from z = 0.05 to 0.9 using a very large and highly spectroscopically complete sample selected by rest-frame NIR bolometric flux in the GOODS-N. We assume a Salpeter IMF and fit Bruzual & Charlot models to compute the galactic stellar masses and extinctions. We determine the expected formed stellar mass density growth rates produced by star formation and compare them with the growth rates measured from the formed stellar mass functions by mass interval. We show that the growth rates match if the IMF is slightly increased from the Salpeter IMF at intermediate masses (~10 M⊙). We investigate the evolution of galaxy color, spectral type, and morphology with mass and redshift and the evolution of mass with environment. We find that applying extinction corrections is critical when analyzing galaxy colors; e.g., nearly all of the galaxies in the green valley are 24 μm sources, but after correcting for extinction, the bulk of the 24 μm sources lie in the blue cloud. We find an evolution of the metallicity-mass relation corresponding to a decrease of 0.21 +/- 0.03 dex between the local value and the value at z = 0.77 in the 1010-1011 M⊙ range. We use the metallicity evolution to estimate the gas mass of the galaxies, which we compare with the galactic stellar mass assembly and star formation histories. Overall, our measurements are consistent with a galaxy evolution process dominated by episodic bursts of star formation and where star formation in the most massive galaxies (gtrsim1011 M⊙) ceases at z Technology, the University of California, and NASA and was made possible by the generous financial support of the W. M. Keck Foundation.

  15. Challenges of Eurasian integration after the Ukrainian Crisis

    Directory of Open Access Journals (Sweden)

    A. Skriba

    2014-05-01

    Full Text Available The regional situation in Eastern Europe changed significantly by the end of the first decade of the 21st century. Competitionbetween Russia and the European Union increased during the 2000s, while at the same time both actors were changing their approach to the six states of the former USSR that lie between Russia and the EU – Azerbaijan, Armenia, Belarus, Georgia, Moldova and Ukraine. In order to widen and deepen their influence on those territories and to reduce uncertainty about their regional politics, Moscow and Brussels developed their own integration projects and demanded those post-Soviet states define their position in the EU-Russia competition. Russian and European scholars, when trying to analyze the future of the Post-Soviet Six states, mostly examine the attractiveness of the two integration projects. While important, such an approach is insufficient, as it ignores the individual internal environments. To assess the prospects for Russia’s Eurasian Economic Union and the EU’s Eastern Partnership, however, one must look inside the six states, which are so important for both Moscow and Brussels. This article explores the aspects of the European and Eurasian integration projects that may be attractive to the six states. Within this framework, it considers what and how elements of those states’ internal environment might influence their choice by examining and comparing both integration projects. It proposes focusing directly on the countries that are currently facing the dilemma of integration and are expected to choose. Despite a number of internal factors influencing the states’ integration behaviour, research has shown that in such circumstances, a choice (whether it is made cannot be considered final, given the individual internal environments of the Six. Their further integration will require additional mechanisms of stimulation, which will need to be developed by the centres of integration — namely, Moscow and

  16. Photonic hybrid assembly through flexible waveguides

    NARCIS (Netherlands)

    Wörhoff, K.; Prak, A.; Postma, F.; Leinse, A.; Wu, K.; Peters, T. J.; Tichem, M.; Amaning-Appiah, B.; Renukappa, V.; Vollrath, G.; Balcells-Ventura, J.; Uhlig, P.; Seyfried, M.; Rose, D.; Santos, R.; Leijtens, X.J.M.; Flintham, B.; Wale, M.; Robbins, D.

    2016-01-01

    Fully automated, high precision, cost-effective assembly technology for photonic packages remains one of the main challenges in photonic component manufacturing. Next to the cost aspect the most demanding assembly task for multiport photonic integrated circuits (PICs) is the high-precision (±0.1 μm)

  17. Photonic hybrid assembly through flexible waveguides

    NARCIS (Netherlands)

    Wörhoff, Kerstin; Prak, Albert; postma, F; Leinse, A; Wu, K.; Peters, T.J.; Tichem, M.; Amaning-Appiah, B.; Renukappa, V.; Vollrath, G.; Balcells-Ventura, J.; Uhlig, P.; Seyfried, M.; Rose, D.; Santos, Raquel; Leijtens, XJM; Flintham, B.; Wale, M.; Robbins, D.; Vivien, Laurent; Pavesi, Lorenzo; Pelli, Stefano

    2016-01-01

    Fully automated, high precision, cost-effective assembly technology for photonic packages remains one of the main challenges in photonic component manufacturing. Next to the cost aspect the most demanding assembly task for multiport photonic integrated circuits (PICs) is the high-precision (±0.1

  18. Challenges of Integrating Unmanned Aerial Vehicles In Civil Application

    International Nuclear Information System (INIS)

    Eid, B M; Albatsh, F; Faris, W F; Chebil, J

    2013-01-01

    Unmanned Aerial Vehicle (UAV) has evolved rapidly over the past decade. There have been an increased number of studies aiming at improving UAV and in its use for different civil applications. This paper highlights the fundamentals of UAV system and examines the challenges related with the major components such as motors, drives, power systems, communication systems and image processing tools and equipment

  19. An integrated approach for determining plutonium mass in spent fuel assemblies with nondestructive assay

    International Nuclear Information System (INIS)

    Swinhoe, Martyn T.; Tobin, Stephen J.; Fensin, Mike L.; Menlove, Howard O.

    2009-01-01

    be part of a system that cost-effectively meets the burnup credit needs of a repository. Behind each of these reasons is a regulatory structure with MC and A requirements. In the case of the IAEA, the accountable quantity is elemental plutonium. The material in spent fuel (fissile isotopes, fission products, etc.) emits signatures that provide information about the content and history of the fuel. A variety of nondestructive assay (NDA) techniques are available to quantify these signatures. The effort presented in this paper is investigation of the capabilities of 12 NDA techniques. For these 12, none is conceptually capable of independently determining the Pu content in a spent fuel assembly while at the same time being able to detect the diversion of a significant quantity of rods. For this reason the authors are investigating the capability of 12 NDA techniques with the end goal of integrating a few techniques together into a system that is capable of measuring Pu mass in an assembly. The work described here is the beginning of what is anticipated to be a five year effort: (1) two years of modeling to select the best technologies, (2) one year fabricating instruments and (3) two years measuring spent fuel. This paper describes the first two years of this work. In order to cost effectively and robustly model the performance of the 12 NDA techniques, an 'assembly library' was created. The library contains the following: (a) A diverse range of PWR spent fuel assemblies (burnup, enrichment, cooling time) similar to that which exists in spent pools today and in the future. (b) Diversion scenarios that capture a range of possible rod removal options. (c) The spatial and isotopic detail needed to accurately quantify the capability of all the NDA techniques so as to enable integration. It is our intention to make this library available to other researchers in the field for inter-comparison purposes. The performance of each instrument will be quantified for the full

  20. European water law in transition: the challenge of integration

    NARCIS (Netherlands)

    Rijswick, H.F.M.W. van

    2005-01-01

    European and domestic national water law have witnessed a number of developments, which can be described as the development from a national territorial approach towards a transnational integrated approach. Initially, Dutch water law for example, sought to offer protection against flooding. More

  1. The Challenges Of Integrating Population Issues Into Development ...

    African Journals Online (AJOL)

    Population dynamic is one of the prime factors for social, economic and technological change worldwide. As population size and composition change in an area, people have to adjust leading to innumerable alterations in the way society operates. The integration of population issues into development planning is crucial.

  2. Challenges of Integrated Pest Management in Sub-Saharan Africa

    NARCIS (Netherlands)

    Huis, van A.

    2009-01-01

    a response to the negative side effects of chemical control in the developed world, Integrated Pest Management (IPM) developed with an emphasis on reducing the role of pesticides. Later the role of natural enemies was recognized as being the cornerstone for sustainable pest management strategies.

  3. Challenges of communicating integrated water resource management in Zimbabwe

    NARCIS (Netherlands)

    Marimbe, S.; Manzungu, E.

    2003-01-01

    With the promulgation of the 1998 Water Act the Government of Zimbabwe took a decisive step to reform the country's water sector, to bring it in line with contemporary socio-political realities obtaining in the country, and in tune with the philosophy of integrated water resources management.

  4. Integration trends in monolithic power ICs: Application and technology challenges

    NARCIS (Netherlands)

    Rose, M.; Bergveld, H.J.

    2016-01-01

    This paper highlights the general trend towards further monolithic integration in power applications by enabling power management and interfacing solutions in advanced CMOS nodes. The need to combine high-density digital circuits, power-management circuits, and robust interfaces in a single

  5. High School Engineering and Technology Education Integration through Design Challenges

    Science.gov (United States)

    Mentzer, Nathan

    2011-01-01

    This study contextualized the use of the engineering design process by providing descriptions of how each element in a design process was integrated in an eleventh grade industry and engineering systems course. The guiding research question for this inquiry was: How do students engage in the engineering design process in a course where technology…

  6. Modelling nutritional mutualisms: challenges and opportunities for data integration.

    Science.gov (United States)

    Clark, Teresa J; Friel, Colleen A; Grman, Emily; Shachar-Hill, Yair; Friesen, Maren L

    2017-09-01

    Nutritional mutualisms are ancient, widespread, and profoundly influential in biological communities and ecosystems. Although much is known about these interactions, comprehensive answers to fundamental questions, such as how resource availability and structured interactions influence mutualism persistence, are still lacking. Mathematical modelling of nutritional mutualisms has great potential to facilitate the search for comprehensive answers to these and other fundamental questions by connecting the physiological and genomic underpinnings of mutualisms with ecological and evolutionary processes. In particular, when integrated with empirical data, models enable understanding of underlying mechanisms and generalisation of principles beyond the particulars of a given system. Here, we demonstrate how mathematical models can be integrated with data to address questions of mutualism persistence at four biological scales: cell, individual, population, and community. We highlight select studies where data has been or could be integrated with models to either inform model structure or test model predictions. We also point out opportunities to increase model rigour through tighter integration with data, and describe areas in which data is urgently needed. We focus on plant-microbe systems, for which a wealth of empirical data is available, but the principles and approaches can be generally applied to any nutritional mutualism. © 2017 John Wiley & Sons Ltd/CNRS.

  7. Regional Economic Integration and the Governance Challenge in ...

    African Journals Online (AJOL)

    There exists a growing consensus among scholars and observers that critical issues on governance and development in Africa, which have remained unresolved, continue to pose obstacles to Africa's economic integration efforts. Although the continent has witnessed different stages in the evolution of regional economic ...

  8. Challenges of implementing an Integrated Disease Surveillance and ...

    African Journals Online (AJOL)

    Tanzania adopted an Integrated Disease Surveillance and Response (IDSR) strategy in 1998 in order to strengthen its infectious disease surveillance system. During that time, the country had 5 separate surveillance systems to monitor infectious disease trends and disease control programmes. The systems included the ...

  9. The Challenge of Assessing Professional Competence in Work Integrated Learning

    Science.gov (United States)

    McNamara, Judith

    2013-01-01

    A fundamental aspect of work integrated learning (WIL) is the development of professional competence, the ability of students to perform in the workplace. Alignment theory therefore suggests that the assessment of WIL should include an assessment of students' demonstration of professional competence in the workplace. The assessment of professional…

  10. An integrated drug prescription and distribution system: challenges and opportunities.

    Science.gov (United States)

    Lanssiers, R; Everaert, E; De Win, M; Van De Velde, R; De Clercq, H

    2002-01-01

    Using the hospital's drug prescription and distribution system as a guide, benefits and drawbacks of a medical activity management system that is tightly integrated with the supply chain management of a hospital will be discussed from the point of view of various participating healthcare actors.

  11. Self-assembly as a design tool for the integration of photonic structures into excitonic solar cells

    KAUST Repository

    Guldin, S.

    2011-09-20

    One way to successfully enhance light harvesting of excitonic solar cells is the integration of optical elements that increase the photon path length in the light absorbing layer. Device architectures which incorporate structural order in form of one- or three-dimensional refractive index lattices can lead to the localization of light in specific parts of the spectrum, while retaining the cell\\'s transparency in others. Herein, we present two routes for the integration of photonic crystals (PCs) into dye-sensitized solar cells (DSCs). In both cases, the self-assembly of soft matter plays a key role in the fabrication process of the TiO2 electrode. One approach relies on a combination of colloidal self-assembly and the self-assembly of block copolymers, resulting in a double layer dye-sensitized solar cell with increased light absorption from the 3D PC element. An alternative route is based on the fact that the refractive index of the mesoporous layer can be finely tuned by the interplay between block copolymer self-assembly and hydrolytic TiO2 sol-gel chemistry. Alternating deposition of high and low refractive index layers enables the integration of a 1D PC into a DSC.

  12. DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.

    Directory of Open Access Journals (Sweden)

    Katherine S Lawrence

    2015-04-01

    Full Text Available Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division. The DNA damage response (DDR, which monitors DNA integrity, and the spindle assembly checkpoint (SAC, which responds to defects in spindle attachment/tension during metaphase of mitosis and meiosis, are critical for preventing genome instability. Here we show that the DDR and SAC function together throughout the cell cycle to ensure genome integrity in C. elegans germ cells. Metaphase defects result in enrichment of SAC and DDR components to chromatin, and both SAC and DDR are required for metaphase delays. During persistent metaphase arrest following establishment of bi-oriented chromosomes, stability of the metaphase plate is compromised in the absence of DDR kinases ATR or CHK1 or SAC components, MAD1/MAD2, suggesting SAC functions in metaphase beyond its interactions with APC activator CDC20. In response to DNA damage, MAD2 and the histone variant CENPA become enriched at the nuclear periphery in a DDR-dependent manner. Further, depletion of either MAD1 or CENPA results in loss of peripherally associated damaged DNA. In contrast to a SAC-insensitive CDC20 mutant, germ cells deficient for SAC or CENPA cannot efficiently repair DNA damage, suggesting that SAC mediates DNA repair through CENPA interactions with the nuclear periphery. We also show that replication perturbations result in relocalization of MAD1/MAD2 in human cells, suggesting that the role of SAC in DNA repair is conserved.

  13. IRaPPA: information retrieval based integration of biophysical models for protein assembly selection.

    Science.gov (United States)

    Moal, Iain H; Barradas-Bautista, Didier; Jiménez-García, Brian; Torchala, Mieczyslaw; van der Velde, Arjan; Vreven, Thom; Weng, Zhiping; Bates, Paul A; Fernández-Recio, Juan

    2017-06-15

    In order to function, proteins frequently bind to one another and form 3D assemblies. Knowledge of the atomic details of these structures helps our understanding of how proteins work together, how mutations can lead to disease, and facilitates the designing of drugs which prevent or mimic the interaction. Atomic modeling of protein-protein interactions requires the selection of near-native structures from a set of docked poses based on their calculable properties. By considering this as an information retrieval problem, we have adapted methods developed for Internet search ranking and electoral voting into IRaPPA, a pipeline integrating biophysical properties. The approach enhances the identification of near-native structures when applied to four docking methods, resulting in a near-native appearing in the top 10 solutions for up to 50% of complexes benchmarked, and up to 70% in the top 100. IRaPPA has been implemented in the SwarmDock server ( http://bmm.crick.ac.uk/∼SwarmDock/ ), pyDock server ( http://life.bsc.es/pid/pydockrescoring/ ) and ZDOCK server ( http://zdock.umassmed.edu/ ), with code available on request. moal@ebi.ac.uk. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  14. The Focal Plane Assembly for the Athena X-Ray Integral Field Unit Instrument

    Science.gov (United States)

    Jackson, B. D.; Van Weers, H.; van der Kuur, J.; den Hartog, R.; Akamatsu, H.; Argan, A.; Bandler, S. R.; Barbera, M.; Barret, D.; Bruijn, M. P.; hide

    2016-01-01

    This paper summarizes a preliminary design concept for the focal plane assembly of the X-ray Integral Field Unit on the Athena spacecraft, an imaging microcalorimeter that will enable high spectral resolution imaging and point-source spectroscopy. The instrument's sensor array will be a 3840-pixel transition edge sensor (TES) microcalorimeter array, with a frequency domain multiplexed SQUID readout system allowing this large-format sensor array to be operated within the thermal constraints of the instrument's cryogenic system. A second TES detector will be operated in close proximity to the sensor array to detect cosmic rays and secondary particles passing through the sensor array for off-line coincidence detection to identify and reject events caused by the in-orbit high-energy particle background. The detectors, operating at 55 mK, or less, will be thermally isolated from the instrument cryostat's 2 K stage, while shielding and filtering within the FPA will allow the instrument's sensitive sensor array to be operated in the expected environment during both on-ground testing and in-flight operation, including stray light from the cryostat environment, low-energy photons entering through the X-ray aperture, low-frequency magnetic fields, and high-frequency electric fields.

  15. THE INTEGRATED REPORTING FRAMEWORK: BETWEEN CHALLENGE AND INNOVATION

    Directory of Open Access Journals (Sweden)

    Tudor OPRIȘOR

    2014-06-01

    Full Text Available Integrated Reporting has lately shown a great amount of interest for the business community, as it can offer a greater information value to all types of users. Thus, creating a proper framework for this type of reporting has been a top priority for the regulating bodies, with significant input from other interested parties. This paper aims to analyze the comments submitted to the Consultation Draft and to determine which questions gained more focus. Moreover, through this paper, we intend to reveal which types of respondents were more interested in discussing the Framework and to split them into several groups of interest. Finally, the main goal of the paper is to provide an overview on the discussions leading to the Framework’s final form and to determine how the comment letters can provide further perspectives on the implementation of Integrated Reporting.

  16. Tailoring the Variational Implicit Solvent Method for New Challenges: Biomolecular Recognition and Assembly

    Directory of Open Access Journals (Sweden)

    Clarisse Gravina Ricci

    2018-02-01

    Full Text Available Predicting solvation free energies and describing the complex water behavior that plays an important role in essentially all biological processes is a major challenge from the computational standpoint. While an atomistic, explicit description of the solvent can turn out to be too expensive in large biomolecular systems, most implicit solvent methods fail to capture “dewetting” effects and heterogeneous hydration by relying on a pre-established (i.e., guessed solvation interface. Here we focus on the Variational Implicit Solvent Method, an implicit solvent method that adds water “plasticity” back to the picture by formulating the solvation free energy as a functional of all possible solvation interfaces. We survey VISM's applications to the problem of molecular recognition and report some of the most recent efforts to tailor VISM for more challenging scenarios, with the ultimate goal of including thermal fluctuations into the framework. The advances reported herein pave the way to make VISM a uniquely successful approach to characterize complex solvation properties in the recognition and binding of large-scale biomolecular complexes.

  17. Tailoring the Variational Implicit Solvent Method for New Challenges: Biomolecular Recognition and Assembly

    Science.gov (United States)

    Ricci, Clarisse Gravina; Li, Bo; Cheng, Li-Tien; Dzubiella, Joachim; McCammon, J. Andrew

    2018-01-01

    Predicting solvation free energies and describing the complex water behavior that plays an important role in essentially all biological processes is a major challenge from the computational standpoint. While an atomistic, explicit description of the solvent can turn out to be too expensive in large biomolecular systems, most implicit solvent methods fail to capture “dewetting” effects and heterogeneous hydration by relying on a pre-established (i.e., guessed) solvation interface. Here we focus on the Variational Implicit Solvent Method, an implicit solvent method that adds water “plasticity” back to the picture by formulating the solvation free energy as a functional of all possible solvation interfaces. We survey VISM's applications to the problem of molecular recognition and report some of the most recent efforts to tailor VISM for more challenging scenarios, with the ultimate goal of including thermal fluctuations into the framework. The advances reported herein pave the way to make VISM a uniquely successful approach to characterize complex solvation properties in the recognition and binding of large-scale biomolecular complexes. PMID:29484300

  18. Producing software by integration: challenges and research directions (keynote)

    OpenAIRE

    Inverardi , Paola; Autili , Marco; Di Ruscio , Davide; Pelliccione , Patrizio; Tivoli , Massimo

    2013-01-01

    International audience; Software is increasingly produced according to a certain goal and by integrating existing software produced by third-parties, typically black-box, and often provided without a machine readable documentation. This implies that development processes of the next future have to explicitly deal with an inherent incompleteness of information about existing software, notably on its behaviour. Therefore, on one side a software producer will less and less know the precise behav...

  19. Integrating patient satisfaction into performance measurement to meet improvement challenges.

    Science.gov (United States)

    Smith, J E; Fisher, D L; Endorf-Olson, J J

    2000-05-01

    A Value Compass has been proposed to guide health care data collection. The "compass corners" represent the four types of data needed to meet health care customer expectations: appropriate clinical outcomes, improved functional status, patient satisfaction, and appropriate costs. Collection of all four types of data is necessary to select processes in need of improvement, guide improvement teams, and monitor the success of improvement efforts. INTEGRATED DATA AT BRYANLGH: BryanLGH Medical Center in Lincoln, Nebraska, has adopted multiple performance measurement systems to collect clinical outcome, financial, and patient satisfaction data into integrated databases. Data integration allows quality professionals at BryanLGH to identify quality issues from multiple perspectives and track the interrelated effects of improvement efforts. A CASE EXAMPLE: Data from the fourth quarter of 1997 indicated the need to improve processes related to cesarean section (C-section) deliveries. An interdisciplinary team was formed, which focused on educating nurses, physicians, and the community about labor support measures. Physicians were given their own rates of C-section deliveries. The C-section rate decreased from 27% to 19%, but per-case cost increased. PickerPLUS+ results indicated that BryanLGH obstetric patients reported fewer problems with receiving information than the Picker norm, but they reported more problems with the involvement of family members and friends. The data collected so far have indicated a decrease in the C-section rate and a need to continue to work on cost and psychosocial issues. A complete analysis of results was facilitated by integrated performance management systems. Successes have been easily tracked over time, and the need for further work on related processes has been clearly identified.

  20. Canadian insights: The challenges of an integrated environmental assessment framework

    International Nuclear Information System (INIS)

    McCaig, Karen

    2005-01-01

    The paper draws results from a review of literature to examine the strengths and weaknesses of the integrated environmental assessment framework in Canada with respect to the inclusion of health impact assessment. Insights include the legislative nature, rigid structure and priority for the natural environment that may restrict progress and the pool of government agencies that need to be convinced of the benefits of health impact assessment that may provide a strong structure for compliance in the long term

  1. Promoting better integration of health information systems: best practices and challenges

    NARCIS (Netherlands)

    Michelsen, K.; Brand, H.; Achterberg, P.; Wilkinson, J.

    2015-01-01

    Health Evidence Network Synthesis Report [Promoting better integration of health information systems: best practices and challenges K Michelsen, H Brand, P Achterberg, J Wilkinson - 2015 ... Authors Kai Michelsen Department of International Health, Maastricht University Maastricht,

  2. MUSE: Challenges to integrate the Multi-Disciplinary field of BB access in one project

    NARCIS (Netherlands)

    Fatome, J.; Pitois, S.; Kamagate, A.; Maillotte, H.; Massoubre., D.; González-Herráez, G.-H.; Smedt, A. de; Brink, R. van den

    2006-01-01

    The present paper discusses the managerial challenges of the MUSE integrated project on multi service broadband access. It addresses different aspects such as matrix organisation, project office, consensus process, standardisation, dissemination, and quality control.

  3. "Excuse me, where's the registration desk?" Report on Integrating Systems for the Robot Challenge AAAI 2002

    National Research Council Canada - National Science Library

    Perzanowski, Dennis; Schultz, Alan C; Adams, William; Bugajska, Magda; Abramson, M; MacMahon, M; Atrash, A; Coblenz, M

    2002-01-01

    ...., and the Naval Research Laboratory -- collaborated and integrated their various robotic systems and interfaces to attempt The Robot Challenge held at the AAAI 2002 annual conference in Edmonton, Alberta...

  4. Becoming Earth Independent: Human-Automation-Robotics Integration Challenges for Future Space Exploration

    Science.gov (United States)

    Marquez, Jessica J.

    2016-01-01

    Future exploration missions will require NASA to integrate more automation and robotics in order to accomplish mission objectives. This presentation will describe on the future challenges facing the human operator (astronaut, ground controllers) as we increase the amount of automation and robotics in spaceflight operations. It will describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. This presentation will outline future human-automation-robotic integration challenges.

  5. Challenges of communicating integrated water resource management in Zimbabwe

    Science.gov (United States)

    Marimbe, Simbiso; Manzungu, Emmanuel

    With the promulgation of the 1998 Water Act the Government of Zimbabwe took a decisive step to reform the country’s water sector, to bring it in line with contemporary socio-political realities obtaining in the country, and in tune with the philosophy of integrated water resources management. Researchers have reported a lack of awareness of the reforms, particularly among the black communities, who were considered not just as one of the target of the reforms, but the beneficiaries. This paper analyses why this has been the case. The paper makes a case for differentiating communication from information dissemination. Information refers to a set of data packaged for delivery to a receiver while communication involves a dialogue. This paper critiques communication strategies used to communicate water reforms in Zimbabwe, applying recent developments in communication theories. The argument in the paper is that there was a failure to communicate although there was some success in dissemination information about the reforms. If the situation is to be reversed then methods that involve audience analysis may have to be used. Such methods tend to be expensive and time consuming--however, there is no substitute to this if integrated water resources management is to be institutionalised among the various stakeholders.

  6. The BuzzFeed Marketing Challenge: An Integrative Social Media Experience

    Science.gov (United States)

    Cowley, Scott W.

    2017-01-01

    This article presents the BuzzFeed Marketing Challenge, which helps students gain integrative real-world marketing experience by selecting a target market, then creating, publishing, and promoting an article for the target market on entertainment publisher BuzzFeed.com. The challenge is for students to effectively use marketing strategy and…

  7. A participatory and integrative approach to increase productivity and comfort in assembly

    NARCIS (Netherlands)

    Looze, M.P. de; Rhijn, G. van; Tuinzaad, B.; Deursen, J. van

    2000-01-01

    Manufacturers of manually assembled products are more and more forced to improve the flow of assembly orders together with a more efficient employment, in order to meet increasing demands on short delivery times, high product variety, good quality and low manufacturing costs. At the same time, the

  8. Catalan Nationalism and Challenges to the Territorial Integrity of Spain

    Directory of Open Access Journals (Sweden)

    G. I. Volkova

    2016-01-01

    Full Text Available At the beginning of the 21st century Spain faced a number of challenges, primarily the growth of separatist sentiments in the regions fraught with the danger of its fragmentation on ethno-national basis. In the context of increased ethno-national mobilization of “small peoples” in Spain one of its most economically developed regions – Catalonia – envisages a rise of the regional identity. Against the backdrop of economic problems generated by the crisis of 2008-2014 the autonomous communities of Spain, including Catalonia, came across the rise of socio-political problems, particularly the growing distance between the society and the central administrative bodies formed in democratic conditions, as well as the two-party administrative system.

  9. The upgrade of integrity analysis module and the mechanical behavior evaluation for the assembly duct

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byoung Oon; Lee, Dong Uk; Kim, Young Il [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-05-01

    The high neutron fluxes and operating temperatures associated with KALIMER are inducing the important radiation damage phenomena, which can cause significant dimensional changes in the core components of the reactor.The thermo-mechanical analysis of the assembly ducts for KALIMER are mainly performed to evaluate the following items.1) change of reactivity. 2) force at pads on core assemblies. 3) withdrawal force at refueling. 4) loading and refueling deviation of assembly ducts. 5) bowing modes for control assembly. In this report, the model for the evaluation of reactivity change as well as the refueling model and the withdrawl force model are upgraded. And the reactivity change is considered as the most important parameter among the above items. Therefore, the sensitivity analyses mainly associated with reactivity change are carried out. As the results, the pad gap between the assembly ducts preliminary driven for keeping the (-) reactivity change. 9 refs., 24 figs., 2 tabs. (Author)

  10. Challenges and promises of integrating knowledge engineering and qualitative methods

    Science.gov (United States)

    Lundberg, C. Gustav; Holm, Gunilla

    Our goal is to expose some of the close ties that exist between knowledge engineering (KE) and qualitative methodology (QM). Many key concepts of qualitative research, for example meaning, commonsense, understanding, and everyday life, overlap with central research concerns in artificial intelligence. These shared interests constitute a largely unexplored avenue for interdisciplinary cooperation. We compare and take some steps toward integrating two historically diverse methodologies by exploring the commonalities of KE and QM both from a substantive and a methodological/technical perspective. In the second part of this essay, we address knowledge acquisition problems and procedures. Knowledge acquisition within KE has been based primarily on cognitive psychology/science foundations, whereas knowledge acquisition within QM has a broader foundation in phenomenology, symbolic interactionism, and ethnomethodology. Our discussion and examples are interdisciplinary in nature. We do not suggest that there is a clash between the KE and QM frameworks, but rather that the lack of communication potentially may limit each framework's future development.

  11. Well integrity in heavy oil wells : challenges and solutions

    Energy Technology Data Exchange (ETDEWEB)

    Taoutaou, S.; Osman, T.M.; Mjthab, M. [Schlumberger (Syrian Arab Republic); Succar, N. [Oudeh Petroleum, Damascus (Syrian Arab Republic)

    2010-07-01

    The Oudeh Petroleum Company (OPC) has used cyclic steam (the Huff and Puff technique) since 2006 to produce heavy oil from its OPC field that has an estimated 79.49 to 95.39 million cubic meters of oil contained in the Jurassic and Triassic reservoirs of the Butmah and Kurachine formations in Syria. Accumulations of oil and gas are present in the main Oudeh structure at depths between 1300 and 2250 meters. The Huff and Puff technique involves 3 phases. In the first phase which lasts about 1 month, steam is injected at 348 degrees C and 17.MPa to melt the wax condensate in the formation in order to decrease heavy oil viscosity. Phase 2 involves 3 soaking days. In phase 3, which lasts 2 to 3 months, the production rate is doubled compared to wells without steam. The cycle is then resumed once the pressure drops. The temperature cycling can compromise the well integrity through loss of hydraulic isolation in the cement sheath and thereby reduce hydrocarbon recovery. This paper described how the OPC has managed to achieved complete well integrity using an advanced cement system in more than 200 wells exposed to steam injection temperatures up to 348 degrees C and the associated high induced thermal stresses. The methodology for risk analysis of the cement sheath failure under steam stimulation was described along with the selection criteria for the advanced cement system to withstand temperature cycling. Two case histories involving a 50 well database were presented. 5 refs., 2 tabs., 13 figs.

  12. Integrative Mixed Methods Data Analytic Strategies in Research on School Success in Challenging Circumstances

    Science.gov (United States)

    Jang, Eunice E.; McDougall, Douglas E.; Pollon, Dawn; Herbert, Monique; Russell, Pia

    2008-01-01

    There are both conceptual and practical challenges in dealing with data from mixed methods research studies. There is a need for discussion about various integrative strategies for mixed methods data analyses. This article illustrates integrative analytic strategies for a mixed methods study focusing on improving urban schools facing challenging…

  13. Integrating Ethics into International Business Teaching: Challenges and Methodologies in the Greater China Context

    Science.gov (United States)

    Whitla, Paul

    2011-01-01

    This paper examines the process of integrating ethics into the teaching of international business within the Greater China region. An example of how ethics is integrated into a required undergraduate international business course at a Hong Kong based university is presented. The contextual challenges of developing a course for use in the Greater…

  14. e-Care integration: To meet the demographic challenge.

    Science.gov (United States)

    Manning, Bryan R M; McKeon Stosuy, Mary

    2006-01-01

    Current multi-agency models of care will be wholly unsustainable when faced with the forecast doubling of over 65s in the developed and developing nations to around 40% of their populations of the next decades. The resulting imbalance between demand and skilled resources is beginning to force radical change towards a fully "joined up" cross-disciplinary, cross-agency service that spans the wide spectrum of medical and social care. This paper offers a basis for a radically revised model that combines end-to-end service processes optimization; the use of integrated assistive technology systems to help the elderly maintain an independent lifestyle; personal risk reduction through medical and status monitoring; extended care-watch and service co-ordination. It then develops an IPTV based approach to provide the necessary infrastructure to underpin provision of these facilities both at home and in the community. These substantial benefits are reviewed and weighed against the inherent loss of privacy that can result from the pervasive computing aspects of the care watch approach, together with the trust building and change management aspects that are inevitably involved in the rationalisation process.

  15. Nurses' hospital orientation and future research challenges: an integrative review.

    Science.gov (United States)

    Peltokoski, J; Vehviläinen-Julkunen, K; Miettinen, M

    2016-03-01

    This study aimed to describe the research on registered nurses' orientation processes in specialized hospital settings in order to illustrate directions for future research. The complex healthcare environment and the impact of nursing shortage and turnover make the hospital orientation process imperative. There is a growing recognition regarding research interests to meet the needs for evidence-based, effective and economically sound hospital orientation strategies. An integrative literature review was performed on publications from the period 2000 to 2013 included in the CINAHL and PubMed databases. English-language studies were included. Themes guiding the analysis were definition of the hospital orientation process, research topics, data collection and instruments and research evidence. Narrative synthesis was used. Eleven papers met the inclusion criteria. The conceptualization of orientation process reflected the complexity of the phenomenon. Less attention has been paid to designs to establish correlations or relationships between selected variables and hospital orientation process. The outcomes of hospital orientation programmes were limited primarily to retention and job satisfaction. The research evidence therefore cannot be evaluated as strong. The lack of an evidence-based approach makes it difficult to develop a comprehensive orientation process. Further research should explore interventions that will enhance the quality of hospital orientation practices to improve nurses' retention and job satisfaction. To provide a comprehensive hospital orientation process, hospital administrators have to put in place human resource development strategies along with practice implications and research efforts. Comprehensive hospital orientation benefits and outcomes should be visible to policy makers. © 2016 International Council of Nurses.

  16. Single Cell and Metagenomic Assemblies: Biology Drives Technical Choices and Goals (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Stepanauskas, Ramunas

    2011-10-13

    DOE JGI's Tanja Woyke, chair of the Single Cells and Metagenomes session, delivers an introduction, followed by Bigelow Laboratory's Ramunas Stepanauskas on "Single Cell and Metagenomic Assemblies: Biology Drives Technical Choices and Goals" at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  17. DOE JGI Quality Metrics; Approaches to Scaling and Improving Metagenome Assembly (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, Alex; Brown, C. Titus

    2011-10-13

    DOE JGI's Alex Copeland on "DOE JGI Quality Metrics" and Michigan State University's C. Titus Brown on "Approaches to Scaling and Improving Metagenome Assembly" at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  18. Comprehensive profiling of retroviral integration sites using target enrichment methods from historical koala samples without an assembled reference genome

    Directory of Open Access Journals (Sweden)

    Pin Cui

    2016-03-01

    Full Text Available Background. Retroviral integration into the host germline results in permanent viral colonization of vertebrate genomes. The koala retrovirus (KoRV is currently invading the germline of the koala (Phascolarctos cinereus and provides a unique opportunity for studying retroviral endogenization. Previous analysis of KoRV integration patterns in modern koalas demonstrate that they share integration sites primarily if they are related, indicating that the process is currently driven by vertical transmission rather than infection. However, due to methodological challenges, KoRV integrations have not been comprehensively characterized. Results. To overcome these challenges, we applied and compared three target enrichment techniques coupled with next generation sequencing (NGS and a newly customized sequence-clustering based computational pipeline to determine the integration sites for 10 museum Queensland and New South Wales (NSW koala samples collected between the 1870s and late 1980s. A secondary aim of this study sought to identify common integration sites across modern and historical specimens by comparing our dataset to previously published studies. Several million sequences were processed, and the KoRV integration sites in each koala were characterized. Conclusions. Although the three enrichment methods each exhibited bias in integration site retrieval, a combination of two methods, Primer Extension Capture and hybridization capture is recommended for future studies on historical samples. Moreover, identification of integration sites shows that the proportion of integration sites shared between any two koalas is quite small.

  19. Deterministic nanoparticle assemblies: from substrate to solution

    International Nuclear Information System (INIS)

    Barcelo, Steven J; Gibson, Gary A; Yamakawa, Mineo; Li, Zhiyong; Kim, Ansoon; Norris, Kate J

    2014-01-01

    The deterministic assembly of metallic nanoparticles is an exciting field with many potential benefits. Many promising techniques have been developed, but challenges remain, particularly for the assembly of larger nanoparticles which often have more interesting plasmonic properties. Here we present a scalable process combining the strengths of top down and bottom up fabrication to generate deterministic 2D assemblies of metallic nanoparticles and demonstrate their stable transfer to solution. Scanning electron and high-resolution transmission electron microscopy studies of these assemblies suggested the formation of nanobridges between touching nanoparticles that hold them together so as to maintain the integrity of the assembly throughout the transfer process. The application of these nanoparticle assemblies as solution-based surface-enhanced Raman scattering (SERS) materials is demonstrated by trapping analyte molecules in the nanoparticle gaps during assembly, yielding uniformly high enhancement factors at all stages of the fabrication process. (paper)

  20. Integrating Photovoltaic Systems in Power System: Power Quality Impacts and Optimal Planning Challenges

    Directory of Open Access Journals (Sweden)

    Aida Fazliana Abdul Kadir

    2014-01-01

    Full Text Available This paper is an overview of some of the main issues in photovoltaic based distributed generation (PVDG. A discussion of the harmonic distortion produced by PVDG units is presented. The maximum permissible penetration level of PVDG in distribution system is also considered. The general procedures of optimal planning for PVDG placement and sizing are also explained in this paper. The result of this review shows that there are different challenges for integrating PVDG in the power systems. One of these challenges is integrated system reliability whereas the amount of power produced by renewable energy source is consistent. Thus, the high penetration of PVDG into grid can decrease the reliability of the power system network. On the other hand, power quality is considered one of the challenges of PVDG whereas the high penetration of PVDGs can lead to more harmonic propagation into the power system network. In addition to that, voltage fluctuation of the integrated PVDG and reverse power flow are two important challenges to this technology. Finally, protection of power system with integrated PVDG is one of the most critical challenges to this technology as the current protection schemes are designed for unidirectional not bidirectional power flow pattern.

  1. Digital Libraries: The Challenge of Integrating Instagram with a Taxonomy for Content Management

    OpenAIRE

    Simona Ibba; Filippo Eros Pani

    2016-01-01

    Interoperability and social implication are two current challenges in the digital library (DL) context. To resolve the problem of interoperability, our work aims to find a relationship between the main metadata schemas. In particular, we want to formalize knowledge through the creation of a metadata taxonomy built with the analysis and the integration of existing schemas associated with DLs. We developed a method to integrate and combine Instagram metadata and hashtags. The final result is a ...

  2. Challenges and Opportunities in the Integration of HIS : Case Study from Zanzibar

    OpenAIRE

    Nyella, Edwin

    2007-01-01

    This thesis presents an in-depth theoretically underpinned empirical analysis of the challenges to integrate the fragmented health information systems within the Zanzibar health care system. The research is situated in the broader topic of health sector reforms, which advocate and implement a number of healthcare organizational changes in which decentralization and integration of the disparate health information systems is one of them. The study sought to meet three objectives: 1) to under...

  3. A Pedagogical Framework for Technology Integration in ESL Classrooms: The Promises and Challenges of Integration

    Science.gov (United States)

    Yang, Sha; Walker, Victoria

    2015-01-01

    Technologies have the potential to support language teaching and learning, but English as a Second Language (ESL) teachers in the United States (U.S.) either sparingly use technologies for instruction or use them at low level. Although previous research has indicated some promises and challenges faced by U.S. ESL teachers with integrating…

  4. An integrated framework for design, management and operation of reconfigurable assembly systems

    NARCIS (Netherlands)

    Manzini, Massimo; Unglert, Johannes Markus; Gyulai, Dávid; Colledani, Marcello; Jauregui Becker, Juan Manuel; Monostori, László; Urgo, Marcello

    2017-01-01

    Manufacturing has to cope with the continuously increasing variety of products, change of volumes and shortening product life cycles. These trends also affect the automotive sector: the frequent introduction of new models, materials and assembly technologies put the suppliers of make-to-order parts

  5. Integrative Governance of Environmental Water in Australia's Murray-Darling Basin: Evolving Challenges and Emerging Pathways.

    Science.gov (United States)

    Bischoff-Mattson, Zachary; Lynch, Amanda H

    2017-07-01

    Integration, a widely promoted response to the multi-scale complexities of social-environmental sustainability, is diversely and sometimes poorly conceptualized. In this paper we explore integrative governance, which we define as an iterative and contextual process for negotiating and advancing the common interest. We ground this definition in a discussion of institutional factors conditioning integrative governance of environmental water in Australia's Murray-Darling Basin. The Murray-Darling Basin is an iconic system of social-ecological complexity, evocative of large-scale conservation challenges in other developed arid river basins. Our critical assessment of integrative governance practices in that context emerges through analysis of interviews with policy participants and documents pertaining to environmental water management in the tri-state area of southwestern New South Wales, northwestern Victoria, and the South Australian Riverland. We identify four linked challenges: (i) decision support for developing socially robust environmental water management goals, (ii) resource constraints on adaptive practice, (iii) inter-state differences in participatory decision-making and devolution of authority, and (iv) representative inclusion in decision-making. Our appraisal demonstrates these as pivotal challenges for integrative governance in the common interest. We conclude by offering a perspective on the potential for supporting integrative governance through the bridging capacity of Australia's Commonwealth Environmental Water Holder.

  6. Integrating complex functions: coordination of nuclear pore complex assembly and membrane expansion of the nuclear envelope requires a family of integral membrane proteins.

    Science.gov (United States)

    Schneiter, Roger; Cole, Charles N

    2010-01-01

    The nuclear envelope harbors numerous large proteinaceous channels, the nuclear pore complexes (NPCs), through which macromolecular exchange between the cytosol and the nucleoplasm occurs. This double-membrane nuclear envelope is continuous with the endoplasmic reticulum and thus functionally connected to such diverse processes as vesicular transport, protein maturation and lipid synthesis. Recent results obtained from studies in Saccharomyces cerevisiae indicate that assembly of the nuclear pore complex is functionally dependent upon maintenance of lipid homeostasis of the ER membrane. Previous work from one of our laboratories has revealed that an integral membrane protein Apq12 is important for the assembly of functional nuclear pores. Cells lacking APQ12 are viable but cannot grow at low temperatures, have aberrant NPCs and a defect in mRNA export. Remarkably, these defects in NPC assembly can be overcome by supplementing cells with a membrane fluidizing agent, benzyl alcohol, suggesting that Apq12 impacts the flexibility of the nuclear membrane, possibly by adjusting its lipid composition when cells are shifted to a reduced temperature. Our new study now expands these findings and reveals that an essential membrane protein, Brr6, shares at least partially overlapping functions with Apq12 and is also required for assembly of functional NPCs. A third nuclear envelope membrane protein, Brl1, is related to Brr6, and is also required for NPC assembly. Because maintenance of membrane homeostasis is essential for cellular survival, the fact that these three proteins are conserved in fungi that undergo closed mitoses, but are not found in metazoans or plants, may indicate that their functions are performed by proteins unrelated at the primary sequence level to Brr6, Brl1 and Apq12 in cells that disassemble their nuclear envelopes during mitosis.

  7. Tipping Points and Balancing Acts: Grand Challenges and Synergistic Opportunities of Integrating Research and Education, Science and Solutions

    Science.gov (United States)

    McCaffrey, M. S.; Stroeve, J. C.

    2011-12-01

    The "Grand Challenges" to address Global Change identified by the International Council for Science (ICSU) and its partners through the Earth System Sustainability Initiative-improving forecasting, enhancing and integrating observation systems, confining and minimizing global environmental change, responding effectively to change, as well as innovating and evaluating these efforts-require an integrative approach that engages and inspires society in general and young people in particular. What are some of the effective strategies-and stumbling blocks-in being able to make Earth System science and related sustainability efforts relevant and practical to non-technical audiences? Recent climate education projects have pioneered new strategies toward linking and infusing research with education, science with solutions. For example, the Climate Literacy and Energy Awareness Network (CLEAN), a National Science Digital Library Pathway funded by NSF, has approached this integral approach by "closing the loop" between climate and energy topics, identifying and annotating high quality online resources relating to the carbon cycle and related topics. The Inspiring Climate Education Excellence (ICEE) project, funded by NASA, offers professional development for teachers that infuses climate science with solutions as an emerging "best practice" while being sensitive to the emotional, psychological and political aspects of avoiding "gloom and doom" on one hand or advocating for particular policy solutions on another. Other examples includes NASA's climate website (http://climate.nasa.gov ), which serves as a robust, engaging portal for climate research and data, especially for educators. The recent PBS series Earth: The Operators' Manual and related book and website are other recent example of how climate science research, education and solutions can be incorporated in a way that is appealing and informative. The Alliance for Climate Education (ACE) has given assemblies in

  8. Burnable absorber-integrated Guide Thimble (BigT) - 1. Design concepts and neutronic characterization on the fuel assembly benchmarks

    International Nuclear Information System (INIS)

    Yahya, Mohd-Syukri; Yu, Hwanyeal; Kim, Yonghee

    2016-01-01

    This paper presents the conceptual designs of a new burnable absorber (BA) for the pressurized water reactor (PWR), which is named 'Burnable absorber-integrated Guide Thimble' (BigT). The BigT integrates BA materials into standard guide thimble in a PWR fuel assembly. Neutronic sensitivities and practical design considerations of the BigT concept are points of highlight in the first half of the paper. Specifically, the BigT concepts are characterized in view of its BA material and spatial self-shielding variations. In addition, the BigT replaceability requirement, bottom-end design specifications and thermal-hydraulic considerations are also deliberated. Meanwhile, much of the second half of the paper is devoted to demonstrate practical viability of the BigT absorbers via comparative evaluations against the conventional BA technologies in representative 17x17 and 16x16 fuel assembly lattices. For the 17x17 lattice evaluations, all three BigT variants are benchmarked against Westinghouse's existing BA technologies, while in the 16x16 assembly analyses, the BigT designs are compared against traditional integral gadolinia-urania rod design. All analyses clearly show that the BigT absorbers perform as well as the commercial BA technologies in terms of reactivity and power peaking management. In addition, it has been shown that sufficiently high control rod worth can be obtained with the BigT absorbers in place. All neutronic simulations were completed using the Monte Carlo Serpent code with ENDF/B-VII.0 library. (author)

  9. ASEAN: perspectives on economic integration: ASEAN capital market integration: issues and challenges

    OpenAIRE

    Datuk Ranjit Ajit Singh

    2009-01-01

    I am grateful for the assistance of Kaleon Leong and Chong Wui Jean in the preparation of this paper. The paper draws on the work of the ASEAN Integration plan and other related papers for which the author gratefully acknowledges. The views expressed in the paper do not necessarily reflect the views of the Securities Commission.

  10. Integrating and Analyzing Psychosocial and Stage Theories To Challenge the Development of the Injured Collegiate Athlete.

    Science.gov (United States)

    Harris, Laura L.

    2003-01-01

    Integrated a psychosocial developmental theory (the Kubler-Ross Stage Theory) and a psychological stage theory (the Ross Stage Theory) and a psychological stage theory (the Chickering and Reisser psychosocial and developmental theory) for challenging injured collegiate student-athletes' personal development. A search of online databases from…

  11. Integrated simulation challenges with the DeepWind floating vertical axis wind turbine concept

    DEFF Research Database (Denmark)

    Verelst, David; Aagaard Madsen, Helge; Borg, Michael

    2015-01-01

    This paper presents the experiences and challenges with concurrently carrying out numerical model development, integrated simulations and design of a novel floating vertical axis wind turbine, the DeepWind concept. The floating VAWT modelling capabilities of the aero-hydro-elastic HAWC2 simulation...

  12. Organic Coasts? Regulatory Challenges of Certifying Integrated Shrimp-Mangrove Production Systems in Vietnam

    Science.gov (United States)

    Ha, Tran Thi Thu; Bush, Simon R.; Mol, Arthur P. J.; van Dijk, Han

    2012-01-01

    The Vietnamese government aims to expand the scale of Naturland certified organic production in integrated shrimp-mangrove farming systems across the coast of Ca Mau province by 2015. In doing so the division between public and private regulation has become blurred. We analyze the government's goal by examining the regulatory challenges of using…

  13. Moving NASA Beyond Low Earth Orbit: Future Human-Automation-Robotic Integration Challenges

    Science.gov (United States)

    Marquez, Jessica

    2016-01-01

    This presentation will provide an overview of current human spaceflight operations. It will also describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. Additionally, there are many implications regarding advanced automation and robotics, and this presentation will outline future human-automation-robotic integration challenges.

  14. Challenges Implementing Work-Integrated Learning in Human Resource Management University Courses

    Science.gov (United States)

    Rook, Laura

    2017-01-01

    The examination of work-integrated learning (WIL) programs in the undergraduate Human Resource Management (HRM) curriculum is an area under-represented in the Australian literature. This paper identifies the challenges faced in implementing WIL into the HRM undergraduate curriculum. Qualitative semi-structured interviews were conducted with 38…

  15. Integrating Quantitative and Qualitative Data in Mixed Methods Research--Challenges and Benefits

    Science.gov (United States)

    Almalki, Sami

    2016-01-01

    This paper is concerned with investigating the integration of quantitative and qualitative data in mixed methods research and whether, in spite of its challenges, it can be of positive benefit to many investigative studies. The paper introduces the topic, defines the terms with which this subject deals and undertakes a literature review to outline…

  16. Ceramic Integration Technologies for Advanced Energy Systems: Critical Needs, Technical Challenges, and Opportunities

    Science.gov (United States)

    Singh, Mrityunjay

    2010-01-01

    Advanced ceramic integration technologies dramatically impact the energy landscape due to wide scale application of ceramics in all aspects of alternative energy production, storage, distribution, conservation, and efficiency. Examples include fuel cells, thermoelectrics, photovoltaics, gas turbine propulsion systems, distribution and transmission systems based on superconductors, nuclear power generation and waste disposal. Ceramic integration technologies play a key role in fabrication and manufacturing of large and complex shaped parts with multifunctional properties. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various needs, challenges, and opportunities in design, fabrication, and testing of integrated similar (ceramic ceramic) and dissimilar (ceramic metal) material www.nasa.gov 45 ceramic-ceramic-systems have been discussed. Experimental results for bonding and integration of SiC based Micro-Electro-Mechanical-Systems (MEMS) LDI fuel injector and advanced ceramics and composites for gas turbine applications are presented.

  17. Monocular Camera/IMU/GNSS Integration for Ground Vehicle Navigation in Challenging GNSS Environments

    Directory of Open Access Journals (Sweden)

    Dennis Akos

    2012-03-01

    Full Text Available Low-cost MEMS-based IMUs, video cameras and portable GNSS devices are commercially available for automotive applications and some manufacturers have already integrated such facilities into their vehicle systems. GNSS provides positioning, navigation and timing solutions to users worldwide. However, signal attenuation, reflections or blockages may give rise to positioning difficulties. As opposed to GNSS, a generic IMU, which is independent of electromagnetic wave reception, can calculate a high-bandwidth navigation solution, however the output from a self-contained IMU accumulates errors over time. In addition, video cameras also possess great potential as alternate sensors in the navigation community, particularly in challenging GNSS environments and are becoming more common as options in vehicles. Aiming at taking advantage of these existing onboard technologies for ground vehicle navigation in challenging environments, this paper develops an integrated camera/IMU/GNSS system based on the extended Kalman filter (EKF. Our proposed integration architecture is examined using a live dataset collected in an operational traffic environment. The experimental results demonstrate that the proposed integrated system provides accurate estimations and potentially outperforms the tightly coupled GNSS/IMU integration in challenging environments with sparse GNSS observations.

  18. Monocular camera/IMU/GNSS integration for ground vehicle navigation in challenging GNSS environments.

    Science.gov (United States)

    Chu, Tianxing; Guo, Ningyan; Backén, Staffan; Akos, Dennis

    2012-01-01

    Low-cost MEMS-based IMUs, video cameras and portable GNSS devices are commercially available for automotive applications and some manufacturers have already integrated such facilities into their vehicle systems. GNSS provides positioning, navigation and timing solutions to users worldwide. However, signal attenuation, reflections or blockages may give rise to positioning difficulties. As opposed to GNSS, a generic IMU, which is independent of electromagnetic wave reception, can calculate a high-bandwidth navigation solution, however the output from a self-contained IMU accumulates errors over time. In addition, video cameras also possess great potential as alternate sensors in the navigation community, particularly in challenging GNSS environments and are becoming more common as options in vehicles. Aiming at taking advantage of these existing onboard technologies for ground vehicle navigation in challenging environments, this paper develops an integrated camera/IMU/GNSS system based on the extended Kalman filter (EKF). Our proposed integration architecture is examined using a live dataset collected in an operational traffic environment. The experimental results demonstrate that the proposed integrated system provides accurate estimations and potentially outperforms the tightly coupled GNSS/IMU integration in challenging environments with sparse GNSS observations.

  19. Monocular Camera/IMU/GNSS Integration for Ground Vehicle Navigation in Challenging GNSS Environments

    Science.gov (United States)

    Chu, Tianxing; Guo, Ningyan; Backén, Staffan; Akos, Dennis

    2012-01-01

    Low-cost MEMS-based IMUs, video cameras and portable GNSS devices are commercially available for automotive applications and some manufacturers have already integrated such facilities into their vehicle systems. GNSS provides positioning, navigation and timing solutions to users worldwide. However, signal attenuation, reflections or blockages may give rise to positioning difficulties. As opposed to GNSS, a generic IMU, which is independent of electromagnetic wave reception, can calculate a high-bandwidth navigation solution, however the output from a self-contained IMU accumulates errors over time. In addition, video cameras also possess great potential as alternate sensors in the navigation community, particularly in challenging GNSS environments and are becoming more common as options in vehicles. Aiming at taking advantage of these existing onboard technologies for ground vehicle navigation in challenging environments, this paper develops an integrated camera/IMU/GNSS system based on the extended Kalman filter (EKF). Our proposed integration architecture is examined using a live dataset collected in an operational traffic environment. The experimental results demonstrate that the proposed integrated system provides accurate estimations and potentially outperforms the tightly coupled GNSS/IMU integration in challenging environments with sparse GNSS observations. PMID:22736999

  20. Integration of scholastic curriculum in computergames – impossible or a design challenge?

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel

    The present paper argues that integration of scholastic knowledge in computer games is a design challenge and one that will only work if you preserve the computer game as a game. This is important cause if you don’t adhere to or understand the dynamics of computer games you run the risk of destro......The present paper argues that integration of scholastic knowledge in computer games is a design challenge and one that will only work if you preserve the computer game as a game. This is important cause if you don’t adhere to or understand the dynamics of computer games you run the risk...... of destroying your own goal. In order to integrate the scholastic curriculum in computer games for a learning purpose it is and can not be stressed enough important to preserve the action-outcome circle inside the game world. Stated in simpler terms this means that users of learning games must see...

  1. Heterogeneous Electronics – Wafer Level Integration, Packaging, and Assembly Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility integrates active electronics with microelectromechanical (MEMS) devices at the miniature system scale. It obviates current size-, weight-, and power...

  2. Digital gene expression analysis based on integrated de novo transcriptome assembly of sweet potato [Ipomoea batatas (L. Lam].

    Directory of Open Access Journals (Sweden)

    Xiang Tao

    Full Text Available BACKGROUND: Sweet potato (Ipomoea batatas L. [Lam.] ranks among the top six most important food crops in the world. It is widely grown throughout the world with high and stable yield, strong adaptability, rich nutrient content, and multiple uses. However, little is known about the molecular biology of this important non-model organism due to lack of genomic resources. Hence, studies based on high-throughput sequencing technologies are needed to get a comprehensive and integrated genomic resource and better understanding of gene expression patterns in different tissues and at various developmental stages. METHODOLOGY/PRINCIPAL FINDINGS: Illumina paired-end (PE RNA-Sequencing was performed, and generated 48.7 million of 75 bp PE reads. These reads were de novo assembled into 128,052 transcripts (≥ 100 bp, which correspond to 41.1 million base pairs, by using a combined assembly strategy. Transcripts were annotated by Blast2GO and 51,763 transcripts got BLASTX hits, in which 39,677 transcripts have GO terms and 14,117 have ECs that are associated with 147 KEGG pathways. Furthermore, transcriptome differences of seven tissues were analyzed by using Illumina digital gene expression (DGE tag profiling and numerous differentially and specifically expressed transcripts were identified. Moreover, the expression characteristics of genes involved in viral genomes, starch metabolism and potential stress tolerance and insect resistance were also identified. CONCLUSIONS/SIGNIFICANCE: The combined de novo transcriptome assembly strategy can be applied to other organisms whose reference genomes are not available. The data provided here represent the most comprehensive and integrated genomic resources for cloning and identifying genes of interest in sweet potato. Characterization of sweet potato transcriptome provides an effective tool for better understanding the molecular mechanisms of cellular processes including development of leaves and storage roots

  3. Temporal integration of consecutive tones into synthetic vowels demonstrates perceptual assembly in audition

    NARCIS (Netherlands)

    Saija, Jefta D.; Andringa, Tjeerd C.; Başkent, Deniz; Akyürek, Elkan G.

    Temporal integration is the perceptual process combining sensory stimulation over time into longer percepts that can span over 10 times the duration of a minimally detectable stimulus. Particularly in the auditory domain, such "long-term" temporal integration has been characterized as a relatively

  4. Cyber-Security Challenges with SMEs in Developing Economies: Issues of Confidentiality, Integrity & Availability (CIA)

    DEFF Research Database (Denmark)

    Yeboah-Boateng, Ezer Osei

    The essence of this study is first to highlight the cyber-security challenges confronting SMEs in developing economies, and to model a framework for safeguarding their assets, to ensure continuous optimal business operations, and to participate and compete securely in the ubiquitous cyber......, to develop customer-centric strategies. While connectivity is indispensable for achieving business success, being connected also implies being exposed to a myriad of cyber-security challenges, such as vulnerabilities of confidentiality, integrity and availability (CIA). As vulnerabilities are exploited...... cognitive map (FCM) approach is also used to show the implications of vulnerabilities amongst SMEs asset disposal policies....

  5. Au–Sn bonding material for the assembly of power integrated circuit module

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Z.X.; Li, C.C. [Department of Materials Science & Engineering, National Taiwan University, Taipei, Taiwan (China); Liao, L.L.; Liu, C.K. [Electronic and Optoelectronics Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan (China); Kao, C.R., E-mail: crkao@ntu.edu.tw [Department of Materials Science & Engineering, National Taiwan University, Taipei, Taiwan (China)

    2016-06-25

    Insulated gate bipolar transistor (IGBT) chips are the key components in high-temperature power electronic modules, which have to efficiently convert electricity between direct and alternating current. In this study, the eutectic Au–Sn (20 wt.% Sn) is successfully used to assemble IGBT chips and direct-bond-copper substrates by using solid liquid interdiffusion (SLID) bonding. During subsequent isothermal aging at 150, 200, and 240 °C, the microstructure evolution and growth kinetics of intermetallic compounds are investigated. Excellent thermal stability and mechanical strength are observed. It is concluded that the eutectic Au–Sn solder is ideal to assemble high-temperature IGBT by using the SLID process. - Highlights: • Au–20Sn serves as a promising bonding material for IGBT operating at T < 519 °C. • The Au–20Sn reacted with Ni to form (Ni,Au){sub 3}Sn{sub 2}/(Au{sub 5}Sn + AuSn)/(Ni,Au){sub 3}Sn{sub 2}. • Once the AuSn was nearly exhausted, the whole joint could withstand higher temperatures. • A cost-effective way for long-term operations at high temperature.

  6. Development of High Throughput Salt Separation System with Integrated Liquid Salt Separation - Salt Distillation Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Sangwoon; Park, K. M.; Kim, J. G.; Jeong, J. H.; Lee, S. J.; Park, S. B.; Kim, S. S.

    2013-01-15

    The capacity of a salt distiller should be sufficiently large to reach the throughput of uranium electro-refining process. In this study, an assembly composing a liquid separation sieve and a distillation crucible was developed for the sequential operation of a liquid salt separation and a vacuum distillation in the same tower. The feasibility of the sequential salt separation was examined by the rotation test of the sieve-crucible assembly and sequential operation of a liquid salt separation and a vacuum distillation. The adhered salt in the uranium deposits was removed successfully. The salt content in the deposits was below 0.1 wt% after the sequential operation of the liquid salt separation - salt distillation. From the results of this study, it could be concluded that efficient salt separation can be realized by the sequential operation of liquid salt separation and vacuum distillation in one distillation tower since the operation procedures are simplified and no extra operation of cooling and reheating is necessary.

  7. Strategies for Integrated Analysis of Genetic, Epigenetic, and Gene Expression Variation in Cancer: Addressing the Challenges

    DEFF Research Database (Denmark)

    Thingholm, Louise Bruun; Andersen, Lars; Makalic, Enes

    2016-01-01

    to integration strategies used for analyzing genetic risk factors for cancer. We critically examine the ability of these strategies to handle the complexity of the human genome and also accommodate information about the biological and functional interactions between the elements that have been measured......The development and progression of cancer, a collection of diseases with complex genetic architectures, is facilitated by the interplay of multiple etiological factors. This complexity challenges the traditional single-platform study design and calls for an integrated approach to data analysis...

  8. Administrative Challenges to the Integration of Oral Health With Primary Care

    Science.gov (United States)

    Maxey, Hannah L.; Randolph, Courtney; Gano, Laura; Kochhar, Komal

    2017-01-01

    Inadequate access to preventive oral health services contributes to oral health disparities and is a major public health concern in the United States. Federally Qualified Health Centers play a critical role in improving access to care for populations affected by oral health disparities but face a number of administrative challenges associated with implementation of oral health integration models. We conducted a SWOT (strengths, weaknesses, opportunities, and threats) analysis with health care executives to identify strengths, weaknesses, opportunities, and threats of successful oral health integration in Federally Qualified Health Centers. Four themes were identified: (1) culture of health care organizations; (2) operations and administration; (3) finance; and (4) workforce. PMID:27218701

  9. Integration of Environmental Issues in a Physics Course: 'Physics by Inquiry' High School Teachers' Integration Models and Challenges

    Science.gov (United States)

    Kimori, David Abiya

    As we approach the second quarter of the twenty-first century, one may predict that the environment will be among the dominant themes in the political and educational discourse. Over the past three decades, particular perspectives regarding the environment have begun to emerge: (i) realization by human beings that we not only live on earth and use its resources at an increasingly high rate but we also actually belong to the earth and the total ecology of all living systems, (ii) there are strong interactions among different components of the large and complex systems that make up our environment, and (iii) the rising human population and its impact on the environment is a great concern (Hughes & Mason, 2014). Studies have revealed that although the students do not have a deep understanding of environmental issues and lack environmental awareness and attitudes necessary for protecting the environment, they have great concern for the environment (Chapman & Sharma, 2001; Fien, Yencken, & Sykes, 2002). However, addressing environmental issues in the classroom and other disciplines has never been an easy job for teachers (Pennock & Bardwell, 1994; Edelson, 2007). Using multiple case studies, this study investigated how three purposefully selected physics teachers teaching a 'Physics by Inquiry' course integrated environmental topics and issues in their classroom. Particularly this study looked at what integration models and practices the three physics teachers employed in integrating environmental topics and issues in their classroom and what challenges the teachers faced while integrating environmental topics in their classrooms. Data collection methods including field notes taken from observations, teachers' interviews and a collection of artifacts and documents were used. The data were coded analyzed and organized into codes and categories guided by Fogarty (1991) models of curriculum integration and Ham and Sewing (1988) four categories of barriers to environmental

  10. Performance Improvement of Receivers Based on Ultra-Tight Integration in GNSS-Challenged Environments

    Directory of Open Access Journals (Sweden)

    Feng Qin

    2013-12-01

    Full Text Available Ultra-tight integration was first proposed by Abbott in 2003 with the purpose of integrating a global navigation satellite system (GNSS and an inertial navigation system (INS. This technology can improve the tracking performances of a receiver by reconfiguring the tracking loops in GNSS-challenged environments. In this paper, the models of all error sources known to date in the phase lock loops (PLLs of a standard receiver and an ultra-tightly integrated GNSS/INS receiver are built, respectively. Based on these models, the tracking performances of the two receivers are compared to verify the improvement due to the ultra-tight integration. Meanwhile, the PLL error distributions of the two receivers are also depicted to analyze the error changes of the tracking loops. These results show that the tracking error is significantly reduced in the ultra-tightly integrated GNSS/INS receiver since the receiver’s dynamics are estimated and compensated by an INS. Moreover, the mathematical relationship between the tracking performances of the ultra-tightly integrated GNSS/INS receiver and the quality of the selected inertial measurement unit (IMU is derived from the error models and proved by the error comparisons of four ultra-tightly integrated GNSS/INS receivers aided by different grade IMUs.

  11. A self-assembling peptide RADA16-I integrated with spider fibroin uncrystalline motifs

    Directory of Open Access Journals (Sweden)

    Sun L

    2012-02-01

    Full Text Available Lijuan Sun1,2, Xiaojun Zhao1,31West China Hospital Laboratory of Nanomedicine and Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu 610041, Sichuan, China; 2Dept of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China; 3Center for Biomedical Engineering NE47-378, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USAAbstract: Mechanical strength of nanofiber scaffolds formed by the self-assembling peptide RADA16-I or its derivatives is not very good and limits their application. To address this problem, we inserted spidroin uncrystalline motifs, which confer incomparable elasticity and hydrophobicity to spider silk GGAGGS or GPGGY, into the C-terminus of RADA16-I to newly design two peptides: R3 (n-RADARADARADARADA-GGAGGS-c and R4 (n-RADARADARADARADA-GPGGY-c, and then observed the effect of these motifs on biophysical properties of the peptide. Atomic force microscopy, transmitting electron microscopy, and circular dichroism spectroscopy confirm that R3 and R4 display ß-sheet structure and self-assemble into long nanofibers. Compared with R3, the ß-sheet structure and nanofibers formed by R4 are more stable; they change to random coil and unordered aggregation at higher temperature. Rheology measurements indicate that novel peptides form hydrogel when induced by DMEM, and the storage modulus of R3 and R4 hydrogel is 0.5 times and 3 times higher than that of RADA16-I, respectively. Furthermore, R4 hydrogel remarkably promotes growth of liver cell L02 and liver cancer cell SMCC7721 compared with 2D culture, determined by MTT assay. Novel peptides still have potential as hydrophobic drug carriers; they can stabilize pyrene microcrystals in aqueous solution and deliver this into a lipophilic environment, identified by fluorescence emission spectra. Altogether, the spider fibroin motif GPGGY most effectively enhances mechanical

  12. Integrated sulphur management : gas, oil sands, reclamation and the challenges of fluctuating demand

    International Nuclear Information System (INIS)

    Pineau, R.

    2009-01-01

    International Commodities Export Corporation is a privately held company that provides fully integrated service offerings to add maximum value in designing, building, owning, and operating sulphur assets. The company also offers in-house, engineering, procurement and project management, as well as supply management, transportation and distribution services. It also has expertise in marine transportation. This presentation discussed integrated sulphur management, with particular focus on gas, oil sands, reclamation and the challenges of fluctuating demand. The presentation provided an overview of the sulphur market and oil sands sulphur. Key considerations for oil sands producers were also presented. The challenges of fluctuating demand include price and volume considerations; logistics; geography and distance to market; export/offshore versus domestic/United States; seasonal considerations; and an inelastic sulphur market. The presentation concluded with a status update of ICEC's initiative and the advantages of Prince Rupert, an economically viable export infrastructure to producers without onsite forming facilities. figs

  13. High-speed logic integrated circuits with solution-processed self-assembled carbon nanotubes.

    Science.gov (United States)

    Han, Shu-Jen; Tang, Jianshi; Kumar, Bharat; Falk, Abram; Farmer, Damon; Tulevski, George; Jenkins, Keith; Afzali, Ali; Oida, Satoshi; Ott, John; Hannon, James; Haensch, Wilfried

    2017-09-01

    As conventional monolithic silicon technology struggles to meet the requirements for the 7-nm technology node, there has been tremendous progress in demonstrating the scalability of carbon nanotube field-effect transistors down to the size that satisfies the 3-nm node and beyond. However, to date, circuits built with carbon nanotubes have overlooked key aspects of a practical logic technology and have stalled at simple functionality demonstrations. Here, we report high-performance complementary carbon nanotube ring oscillators using fully manufacturable processes, with a stage switching frequency of 2.82 GHz. The circuit was built on solution-processed, self-assembled carbon nanotube arrays with over 99.9% semiconducting purity, and the complementary feature was achieved by employing two different work function electrodes.

  14. High-speed logic integrated circuits with solution-processed self-assembled carbon nanotubes

    Science.gov (United States)

    Han, Shu-Jen; Tang, Jianshi; Kumar, Bharat; Falk, Abram; Farmer, Damon; Tulevski, George; Jenkins, Keith; Afzali, Ali; Oida, Satoshi; Ott, John; Hannon, James; Haensch, Wilfried

    2017-09-01

    As conventional monolithic silicon technology struggles to meet the requirements for the 7-nm technology node, there has been tremendous progress in demonstrating the scalability of carbon nanotube field-effect transistors down to the size that satisfies the 3-nm node and beyond. However, to date, circuits built with carbon nanotubes have overlooked key aspects of a practical logic technology and have stalled at simple functionality demonstrations. Here, we report high-performance complementary carbon nanotube ring oscillators using fully manufacturable processes, with a stage switching frequency of 2.82 GHz. The circuit was built on solution-processed, self-assembled carbon nanotube arrays with over 99.9% semiconducting purity, and the complementary feature was achieved by employing two different work function electrodes.

  15. THE CHALLENGES FOR MARKETING DISTANCE EDUCATION IN ONLINE ENVIRONMENT An Integrated Approach

    OpenAIRE

    Reweved by Natalija LEPKOVA

    2009-01-01

    THE CHALLENGES FOR MARKETING DISTANCE EDUCATION IN ONLINEENVIRONMENT An Integrated ApproachEdited by Prof. Dr. Ugur DEMIRAY,Assist. Prof. Dr. N. Serdar SEVER,Print ISBN 978-975-06-0596-3, Electronic ISBN 978-975-98590-6-0,732pp. 2009, Anadolu University, Eskisehir-Turkey(Available from http://www.midasebook.com)Reviewed by Associate Professor, Natalija LEPKOVADoctor of technological sciencesDepartment of Construction Economicsand Property ManagementVilnius Gediminas Technical University,LITHU...

  16. An ergonomics action research demonstration: integrating human factors into assembly design processes.

    Science.gov (United States)

    Village, J; Greig, M; Salustri, F; Zolfaghari, S; Neumann, W P

    2014-01-01

    In action research (AR), the researcher participates 'in' the actions in an organisation, while simultaneously reflecting 'on' the actions to promote learning for both the organisation and the researchers. This paper demonstrates a longitudinal AR collaboration with an electronics manufacturing firm where the goal was to improve the organisation's ability to integrate human factors (HF) proactively into their design processes. During the three-year collaboration, all meetings, workshops, interviews and reflections were digitally recorded and qualitatively analysed to inform new 'actions'. By the end of the collaboration, HF tools with targets and sign-off by the HF specialist were integrated into several stages of the design process, and engineers were held accountable for meeting the HF targets. We conclude that the AR approach combined with targeting multiple initiatives at different stages of the design process helped the organisation find ways to integrate HF into their processes in a sustainable way. Researchers acted as a catalyst to help integrate HF into the engineering design process in a sustainable way. This paper demonstrates how an AR approach can help achieve HF integration, the benefits of using a reflective stance and one method for reporting an AR study.

  17. Challenges in Incorporating Climate Change Adaptation into Integrated Water Resources Management

    Science.gov (United States)

    Kirshen, P. H.; Cardwell, H.; Kartez, J.; Merrill, S.

    2011-12-01

    Over the last few decades, integrated water resources management (IWRM), under various names, has become the accepted philosophy for water management in the USA. While much is still to be learned about how to actually carry it out, implementation is slowly moving forward - spurred by both legislation and the demands of stakeholders. New challenges to IWRM have arisen because of climate change. Climate change has placed increased demands on the creativities of planners and engineers because they now must design systems that will function over decades of hydrologic uncertainties that dwarf any previous hydrologic or other uncertainties. Climate and socio-economic monitoring systems must also now be established to determine when the future climate has changed sufficiently to warrant undertaking adaptation. The requirements for taking some actions now and preserving options for future actions as well as the increased risk of social inequities in climate change impacts and adaptation are challenging experts in stakeholder participation. To meet these challenges, an integrated methodology is essential that builds upon scenario analysis, risk assessment, statistical decision theory, participatory planning, and consensus building. This integration will create cross-disciplinary boundaries for these disciplines to overcome.

  18. A Qualitative Study Exploring Moral Distress Among Pediatric Resuscitation Team Clinicians: Challenges to Professional Integrity.

    Science.gov (United States)

    Thomas, Tessy A; Thammasitboon, Satid; Balmer, Dorene F; Roy, Kevin; McCullough, Laurence B

    2016-07-01

    Our study objectives were to explore moral distress among pediatric team clinicians within the context of resuscitation experiences, and determine whether there were any distinctively ethical perspectives on moral distress that could be conceptualized as challenges to professional integrity, rather than to previously described psychological responses of clinicians. Descriptive, exploratory qualitative study. A large tertiary pediatric academic hospital in Houston, TX. Twenty-five PICU resuscitation team clinicians were interviewed from December 2012 to April 2013. None. All clinicians reported experiencing moral distress during certain resuscitations. Twenty-one of 25 clinicians reflected and acknowledged that their sense of professional integrity had been challenged during those resuscitation events. Four main components of resuscitation experience that induced moral distress were identified: 1) experiences where there was lack of understanding of the big picture; 2) experiences where there was suboptimal team leadership; 3) experiences where there was variable meanings to the word "resuscitation"; and 4) experiences were there was uncertainty of role responsibility. The perception of moral distress exists among pediatric clinicians during resuscitations and could be conceptualized as challenges to professional integrity. This ethical framework offers an alternative approach to understanding and investigating the complex layers of moral distress.

  19. Developing 21st century skills in chemistry classrooms: Opportunities and challenges of STEAM integration

    Science.gov (United States)

    Hadinugrahaningsih, Tritiyatma; Rahmawati, Yuli; Ridwan, Achmad

    2017-08-01

    The paper portrays the first year of two-year study in integration Science, Technology, Engineering, Art, and Mathematics (STEAM) in chemistry learning. The research focused on developing 21st-century skills of chemistry students in secondary schools. The 21st-century skills as a set of abilities that students need to develop in facing the future challenge which involves learning, literacy, and life skills. The study was conducted in two secondary schools both public and private school in topics of hydrocarbon, petroleum, solubility, and acid base in year 10 and 11. The qualitative methodology was applied to explore the students' learning experiences and understanding the research context. Data was collected through observation, interview, reflective journal, and 21st-century rubric. The STEAM approach was integrated through modification of project-based learning model. The students had opportunities to develop their own projects by integrating chemistry and STEAM principles to their project. The results show that students have developed their critical and creative thinking, problem-solving skills, collaboration and argumentation skills, leadership and responsibility, information and literacy skills. The researchers faced the challenges of integrating STEAM within the chemistry curricula, empowering students, and managing the teaching and time resources. Students have started to challenge their critical and creative thinking within the existing learning environments. Integrating STEAM into chemistry learning has developed students' 21st-century skills in those three areas. Teachers also learned to develop their competencies for being facilitators and agents of change, in addition to skills development in dealing with students' differences.

  20. Incorporating "motivation" into the functional analysis of challenging behavior: on the interactive and integrative potential of the motivating operation.

    Science.gov (United States)

    Langthorne, Paul; McGill, Peter; O'Reilly, Mark

    2007-07-01

    Sensitivity theory attempts to account for the variability often observed in challenging behavior by recourse to the "aberrant motivation" of people with intellectual and developmental disabilities. In this article, we suggest that a functional analysis based on environmental (challenging environments) and biological (challenging needs) motivating operations provides a more parsimonious and empirically grounded account of challenging behavior than that proposed by sensitivity theory. It is argued that the concept of the motivating operation provides a means of integrating diverse strands of research without the undue inference of mentalistic constructs. An integrated model of challenging behavior is proposed, one that remains compatible with the central tenets of functional analysis.

  1. Characteristics of an integrated cathode assembly for the electrolytic reduction of uranium oxide in a LiCl-Li2O molten salt

    International Nuclear Information System (INIS)

    Sung Bin Park; Byung Heung Park; Sang Mun Jeong; Jin Mok Hur; Chung Seok Seo; Seong Won Park; Seung-Hoon Choi

    2006-01-01

    Electrochemical behavior of the reduction of uranium oxide was studied in a LiCl-Li 2 O molten salt system with an integrated cathode assembly. The mechanism for the electrolytic reduction of uranium oxide was studied through cyclic voltammetry. By means of a chronopotentiometry, the effects of the thickness of the uranium oxide, the thickness of the MgO membrane and the material of the conductor of an integrated cathode assembly on the overpotential of the cathode were investigated. From the voltamograms, the reduction potential of the uranium oxide and Li 2 O was obtained and the two mechanisms of the electrolytic reduction were considered with regard to the applied cathode potential. From the chronopotentiograms, the exchange current, the transfer coefficient and the maximum allowable current based on the Tafel behavior were obtained with regard to the thickness of the uranium oxide, and of the MgO membrane and the material of the conductor of an integrated cathode assembly. (author)

  2. Integration Science and Technology of Silicon-Based Ceramics and Composites:Technical Challenges and Opportunities

    Science.gov (United States)

    Singh, M.

    2013-01-01

    Ceramic integration technologies enable hierarchical design and manufacturing of intricate ceramic and composite parts starting with geometrically simpler units that are subsequently joined to themselves and/or to metals to create components with progressively higher levels of complexity and functionality. However, for the development of robust and reliable integrated systems with optimum performance for high temperature applications, detailed understanding of various thermochemical and thermomechanical factors is critical. Different technical approaches are required for the integration of ceramic to ceramic and ceramic to metal systems. Active metal brazing, in particular, is a simple and cost-effective method to integrate ceramic to metallic components. Active braze alloys usually contain a reactive filler metal (e.g., Ti, Cr, V, Hf etc) that promotes wettability and spreading by inducing chemical reactions with the ceramics and composites. In this presentation, various examples of brazing of silicon nitride to themselves and to metallic systems are presented. Other examples of joining of ceramic composites (C/SiC and SiC/SiC) using ceramic interlayers and the resulting microstructures are also presented. Thermomechanical characterization of joints is presented for both types of systems. In addition, various challenges and opportunities in design, fabrication, and testing of integrated similar (ceramic-ceramic) and dissimilar (ceramic-metal) material systems will be discussed. Potential opportunities and need for the development of innovative design philosophies, approaches, and integrated system testing under simulated application conditions will also be presented.

  3. Early Child Development and Nutrition: A Review of the Benefits and Challenges of Implementing Integrated Interventions.

    Science.gov (United States)

    Hurley, Kristen M; Yousafzai, Aisha K; Lopez-Boo, Florencia

    2016-03-01

    Poor nutrition (substandard diet quantity and/or quality resulting in under- or overnutrition) and the lack of early learning opportunities contribute to the loss of developmental potential and life-long health and economic disparities among millions of children aged early child development (ECD) or nutrition have been linked to positive child development and/or nutritional status, and recommendations currently advocate for the development and testing of integrated interventions. We reviewed the theoretical and practical benefits and challenges of implementing integrated nutrition and ECD interventions along with the evidence for best practice and benefit-cost and concluded that the strong theoretical rationale for integration is more nuanced than the questions that the published empirical evidence have addressed. For example, further research is needed to 1) answer questions related to how integrated messaging influences caregiver characteristics such as well-being, knowledge, and behavior and how these influence early child nutrition and development outcomes; 2) understand population and nutritional contexts in which integrated interventions are beneficial; and 3) explore how varying implementation processes influence the efficacy, uptake, and cost-benefit of integrated nutrition and ECD interventions. © 2016 American Society for Nutrition.

  4. New Sustainable Model of Biorefineries: Biofactories and Challenges of Integrating Bio- and Solar Refineries.

    Science.gov (United States)

    Abate, Salvatore; Lanzafame, Paola; Perathoner, Siglinda; Centi, Gabriele

    2015-09-07

    The new scenario for sustainable (low-carbon) chemical and energy production drives the development of new biorefinery concepts (indicated as biofactories) with chemical production at the core, but flexible and small-scale production. An important element is also the integration of solar energy and CO2 use within biobased production. This concept paper, after shortly introducing the motivation and recent trends in this area, particularly at the industrial scale, and some of the possible models (olefin and intermediate/high-added-value chemicals production), discusses the opportunities and needs for research to address the challenge of integrating bio- and solar refineries. Aspects discussed regard the use of microalgae and CO2 valorization in biorefineries/biofactories by chemo- or biocatalysis, including possibilities for their synergetic cooperation and symbiosis, as well as integration within the agroenergy value chain. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Environmental performance and financial report integrity: challenges for the mining sector in Indonesia

    Science.gov (United States)

    Mayangsari, S.

    2018-01-01

    This study investigates the influence of environmental performance on the financial report integrity. The statistics used were primary data from interviews with senior members of the mining sector regarding environmental issues, as well as secondary data using Financial Report 2016. The samples were listed mining companies with semester data. Questionnaires were used to measure their perceptions of the challenges concerning climate change faced by the mining sector. The results of this research show that regulatory interventions will be critical to environmental issues. This study employed KLD as a proxy for environmental performance, correlated with other variables regarding the integrity of disclosure. The outcome indicates that environmental issues will increase the integrity of financial reports.

  6. Integrating climate change adaptation in energy planning and decision-making - Key challenges and opportunities

    DEFF Research Database (Denmark)

    Olhoff, Anne; Olsen, Karen Holm

    2011-01-01

    management framework is used as the basis for identifying key challenges and opportunities to enhance the integration of climate change adaptation in energy planning and decision-making. Given its importance for raising awareness and for stimulating action by planners and decision-makers, emphasis is placed......Energy systems are significantly vulnerable to current climate variability and extreme events. As climate change becomes more pronounced, the risks and vulnerabilities will be exacerbated. To date, energy sector adaptation issues have received very limited attention. In this paper, a climate risk...... barriers to integration of climate risks and adaptive responses in energy planning and decision making. Both detailed assessments of the costs and benefits of integrating adaptation measures and rougher ‘order of magnitude’ estimates would enhance awareness raising and momentum for action....

  7. The Detector Control System of the ATLAS SemiCondutor Tracker during Macro-Assembly and Integration

    CERN Document Server

    Abdesselam, A; Basiladze, S; Bates, R L; Bell, P; Bingefors, N; Böhm, J; Brenner, R; Chamizo-Llatas, M; Clark, A; Codispoti, G; Colijn, A P; D'Auria, S; Dorholt, O; Doherty, F; Ferrari, P; Ferrère, D; Górnicki, E; Koperny, S; Lefèvre, R; Lindquist, L-E; Malecki, P; Mikulec, B; Mohn, B; Pater, J; Pernegger, H; Phillips, P; Robichaud-Véronneau, A; Robinson, D; Roe, S; Sandaker, H; Sfyrla, A; Stanecka, E; Stastny, J; Viehhauser, G; Vossebeld, J; Wells, P

    2008-01-01

    The ATLAS SemiConductor Tracker (SCT) is one of the largest existing semiconductor detectors. It is situated between the Pixel detector and the Transition Radiation Tracker at one of the four interaction points of the Large Hadron Collider (LHC). During 2006-2007 the detector was lowered into the ATLAS cavern and installed in its final position. For the assembly, integration and commissioning phase, a complete Detector Control System (DCS) was developed to ensure the safe operation of the tracker. This included control of the individual powering of the silicon modules, a bi-phase cooling system and various types of sensors monitoring the SCT environment and the surrounding test enclosure. The DCS software architecture, performance and operational experience will be presented in the view of a validation of the DCS for the final SCT installation and operation phase.

  8. Integration and disintegration processes of ethnic communities in a globalized world: challenges and trends

    Directory of Open Access Journals (Sweden)

    A. A. Paronikian

    2016-06-01

    Full Text Available The article examines the challenges and trends in integration and disintegration processes of ethnic communities in the world of globalization. Established that ethnic disintegration is inevitable consequence of ethnic integration, and its intensity depends on what method is carried Integration: voluntary or forced. What is important is the fact that in the era of globalization integration and disintegration processes of ethnic communities that are inherent in the very essence of ethnicity, greatly amplified. It was found that entering to the cultural field of ethnic communities of other ethnic entities, penalized sustainable ethnic balance, contributes to the phenomenon of «rejection of other» causes of ethnic conflict and the consequent threat of disintegration of ethnic communities. Disintegration often leads to weakening of the linkages and interactions between components of the integrated system in a multi-ethnic society. However, the author concludes that the process of disintegration cannot be regarded as unambiguously negative because, on the one hand, it contributes to the weakening and decline; and sometimes division of multi-ethnic countries, but on the other hand - it contributes to the birth of the new and revival of the old nation-states, which is particularly important in conditions of transformation of the global community towards the post-industrial and information epoch in the future. In general, the integration and disintegration change each other depending on global processes and their transformations. Therefore, in the era of globalization’s challenges it is important is the effective management of these processes to prevent adverse effects.

  9. Helping To Integrate The Visually Challenged Into Mainstream Society Through A Low-Cost Braille Device

    Directory of Open Access Journals (Sweden)

    Desirée Jordan

    2013-06-01

    Full Text Available The visually challenged are often alienated from mainstream society because of their disabilities. This problem is even more pronounced in developing countries which often do not have the resources necessary to integrate this people group into their communities or even help them to become independent. It should therefore be the aim of governments in developing countries to provide this vulnerable people group with access to assistive technologies at a low cost. This paper describes an ongoing project that aims to provide low-cost assistive technologies to the visually challenged in Barbados. As a part of this project a study was conducted on a sample of visually challenged members of the Barbados Association for the Blind and Deaf to determine their ICT skills, knowledge of Braille and their use of assistive technologies. An analysis of the results prompted the design and creation of a low-cost Braille device prototype. The cost of this prototype was about one-half that of a commercially available device and can be used without a screen reader. This device should help create equal opportunities for the visually challenged in Barbados and other developing countries. It should also allow the visually challenged to become more independent.

  10. Reframing the challenges to integrated care: a complex-adaptive systems perspective

    Directory of Open Access Journals (Sweden)

    Peter Tsasis

    2012-09-01

    Full Text Available Introduction: Despite over two decades of international experience and research on health systems integration, integrated care has not developed widely. We hypothesized that part of the problem may lie in how we conceptualize the integration process and the complex systems within which integrated care is enacted. This study aims to contribute to discourse regarding the relevance and utility of a complex-adaptive systems (CAS perspective on integrated care.Methods: In the Canadian province of Ontario, government mandated the development of fourteen Local Health Integration Networks in 2006. Against the backdrop of these efforts to integrate care, we collected focus group data from a diverse sample of healthcare professionals in the Greater Toronto Area using convenience and snowball sampling. A semi-structured interview guide was used to elicit participant views and experiences of health systems integration. We use a CAS framework to describe and analyze the data, and to assess the theoretical fit of a CAS perspective with the dominant themes in participant responses.Results: Our findings indicate that integration is challenged by system complexity, weak ties and poor alignment among professionals and organizations, a lack of funding incentives to support collaborative work, and a bureaucratic environment based on a command and control approach to management. Using a CAS framework, we identified several characteristics of CAS in our data, including diverse, interdependent and semi-autonomous actors; embedded co-evolutionary systems; emergent behaviours and non-linearity; and self-organizing capacity. Discussion and Conclusion: One possible explanation for the lack of systems change towards integration is that we have failed to treat the healthcare system as complex-adaptive. The data suggest that future integration initiatives must be anchored in a CAS perspective, and focus on building the system's capacity to self-organize. We conclude that

  11. Reframing the challenges to integrated care: a complex-adaptive systems perspective

    Directory of Open Access Journals (Sweden)

    Peter Tsasis

    2012-09-01

    Full Text Available Introduction: Despite over two decades of international experience and research on health systems integration, integrated care has not developed widely. We hypothesized that part of the problem may lie in how we conceptualize the integration process and the complex systems within which integrated care is enacted. This study aims to contribute to discourse regarding the relevance and utility of a complex-adaptive systems (CAS perspective on integrated care. Methods: In the Canadian province of Ontario, government mandated the development of fourteen Local Health Integration Networks in 2006. Against the backdrop of these efforts to integrate care, we collected focus group data from a diverse sample of healthcare professionals in the Greater Toronto Area using convenience and snowball sampling. A semi-structured interview guide was used to elicit participant views and experiences of health systems integration. We use a CAS framework to describe and analyze the data, and to assess the theoretical fit of a CAS perspective with the dominant themes in participant responses. Results: Our findings indicate that integration is challenged by system complexity, weak ties and poor alignment among professionals and organizations, a lack of funding incentives to support collaborative work, and a bureaucratic environment based on a command and control approach to management. Using a CAS framework, we identified several characteristics of CAS in our data, including diverse, interdependent and semi-autonomous actors; embedded co-evolutionary systems; emergent behaviours and non-linearity; and self-organizing capacity.  Discussion and Conclusion: One possible explanation for the lack of systems change towards integration is that we have failed to treat the healthcare system as complex-adaptive. The data suggest that future integration initiatives must be anchored in a CAS perspective, and focus on building the system's capacity to self-organize. We conclude that

  12. Lessons learned and new challenges for integrated assessment under the National Environmental Policy Act

    Energy Technology Data Exchange (ETDEWEB)

    Carnes, S.A.; Reed, R.M.

    1995-12-31

    One of the first government-sponsored demands for integrated assessment to support decision making in the United States is embodied in the National Environmental Policy Act of 1969 (NEPA). Over the past 25 years, Oak Ridge National Laboratory (ORNL) has supported federal agencies` in evaluating health and environmental impacts as required by NEPA. Many of ORNL`s efforts have focused on complex, programmatic assessments that break new ground and require and integrate expertise from a wide range of technical disciplines. Examples of ORNL projects that illustrate the use of integrated assessment approaches include environmental documentation for: (1) the Department of the Army`s Chemical Stockpile Disposal Program, (2) the Federal Energy Regulatory Commission`s licensing activities related to the Owens River Basin in eastern California and along a 500-mile reach of the upper Ohio River, and (3) the Nuclear Regulatory Commission`s decision regarding restart of the undamaged reactor (Unit 1) at Three Mile Island. Our discussion of these examples illustrates successful integrated assessment approaches and identifies new challenges facing integrated assessment activities.

  13. Reverse osmosis integrity monitoring in water reuse: The challenge to verify virus removal - A review.

    Science.gov (United States)

    Pype, Marie-Laure; Lawrence, Michael G; Keller, Jurg; Gernjak, Wolfgang

    2016-07-01

    A reverse osmosis (RO) process is often included in the treatment train to produce high quality reuse water from treated effluent for potable purposes because of its high removal efficiency for salinity and many inorganic and organic contaminants, and importantly, it also provides an excellent barrier for pathogens. In order to ensure the continued protection of public health from pathogen contamination, monitoring RO process integrity is necessary. Due to their small sizes, viruses are the most difficult class of pathogens to be removed in physical separation processes and therefore often considered the most challenging pathogen to monitor. To-date, there is a gap between the current log credit assigned to this process (determined by integrity testing approved by regulators) and its actual log removal capability as proven in a variety of laboratory and pilot studies. Hence, there is a challenge to establish a methodology that more closely links to the theoretical performance. In this review, after introducing the notion of risk management in water reuse, we provide an overview of existing and potentially new RO integrity monitoring techniques, highlight their strengths and drawbacks, and debate their applicability to full-scale treatment plants, which open to future research opportunities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Integrating Environmental and Human Health Databases in the Great Lakes Basin: Themes, Challenges and Future Directions

    Directory of Open Access Journals (Sweden)

    Kate L. Bassil

    2015-03-01

    Full Text Available Many government, academic and research institutions collect environmental data that are relevant to understanding the relationship between environmental exposures and human health. Integrating these data with health outcome data presents new challenges that are important to consider to improve our effective use of environmental health information. Our objective was to identify the common themes related to the integration of environmental and health data, and suggest ways to address the challenges and make progress toward more effective use of data already collected, to further our understanding of environmental health associations in the Great Lakes region. Environmental and human health databases were identified and reviewed using literature searches and a series of one-on-one and group expert consultations. Databases identified were predominantly environmental stressors databases, with fewer found for health outcomes and human exposure. Nine themes or factors that impact integration were identified: data availability, accessibility, harmonization, stakeholder collaboration, policy and strategic alignment, resource adequacy, environmental health indicators, and data exchange networks. The use and cost effectiveness of data currently collected could be improved by strategic changes to data collection and access systems to provide better opportunities to identify and study environmental exposures that may impact human health.

  15. Integrating precision cancer medicine into healthcare—policy, practice, and research challenges

    Directory of Open Access Journals (Sweden)

    Gabrielle Bertier

    2016-10-01

    Full Text Available Abstract Precision medicine (PM can be defined as a predictive, preventive, personalized, and participatory healthcare service delivery model. Recent developments in molecular biology and information technology make PM a reality today through the use of massive amounts of genetic, ‘omics’, clinical, environmental, and lifestyle data. With cancer being one of the most prominent public health threats in developed countries, both the research community and governments have been investing significant time, money, and efforts in precision cancer medicine (PCM. Although PCM research is extremely promising, a number of hurdles still remain on the road to an optimal integration of standardized and evidence-based use of PCM in healthcare systems. Indeed, PCM raises a number of technical, organizational, ethical, legal, social, and economic challenges that have to be taken into account in the development of an appropriate health policy framework. Here, we highlight some of the more salient issues regarding the standards needed for integration of PCM into healthcare systems, and we identify fields where more research is needed before policy can be implemented. Key challenges include, but are not limited to, the creation of new standards for the collection, analysis, and sharing of samples and data from cancer patients, and the creation of new clinical trial designs with renewed endpoints. We believe that these issues need to be addressed as a matter of priority by public health policymakers in the coming years for a better integration of PCM into healthcare.

  16. Simulating power integration in Latin America to assess challenges, opportunities, and threats

    International Nuclear Information System (INIS)

    Ochoa, Camila; Dyner, Isaac; Franco, Carlos J.

    2013-01-01

    Integration of electricity markets started to spread under the world-wide trend to economic liberalization. While some regions are managing better than others, lessons, both political and technical, highlight challenges ahead that need to be overcome. Since the early 2000s, Panama, Colombia, Ecuador, and Peru have decided to integrate their electricity markets, eventually creating an enormous Latin American electricity exchange, ranging from Mexico to Chile. This poses opportunities and threats to the region as it involves cooperation, trust, and the will to overcome difficulties that may arise. In this direction, we developed a system dynamics model, linked to an iterative algorithm, to assess the likely effects of integration on both system expansion and security of supply. The model helps us understand the logic of the long-term system behavior under different policies, assuming Market Coupling as the dispatch mechanism. Based on theoretical grounds and after analyzing simulation results under different scenarios, we conclude that the integration of electricity markets may render important opportunities regarding security of supply and efficiency; and consequently energy might be supplied at lower prices, using “cleaner” technologies. However, benefits largely depend on policy, regulation, and technical issues. - Highlights: • We model the likely long-term dynamics of regional integration in Latin America. • The approach includes a dispatch algorithm linked to a system dynamics model. • The model simulates the evolution of installed capacity and prices. • We conclude: electricity integration may provide security of supply and efficiency. • Benefits of integration largely depend on policy, regulation, and technical issues

  17. European radiographers' challenges from mammography education and clinical practice - an integrative review.

    Science.gov (United States)

    Metsälä, Eija; Richli Meystre, Nicole; Pires Jorge, José; Henner, Anja; Kukkes, Tiina; Sá Dos Reis, Cláudia

    2017-06-01

    This study aims to identify European radiographers' challenges in clinical performance in mammography and the main areas of mammography that require more and better training. An extensive search was performed to identify relevant studies focused on clinical practice, education and training in mammography published between January 2010 and December 2015 in the English language. The data were analysed by using deductive thematic analysis. A total of 27 full text articles were read, evaluating their quality. Sixteen articles out of 27 were finally selected for this integrative review. The main challenges of radiographers' mammography education/training can be divided into three groups: training needs, challenges related to radiographers, and challenges related to the organization of education. The most common challenges of clinical performance in mammography among European radiographers involved technical performance, the quality of practices, and patient-centeredness. The introduction of harmonized mammography guidelines across Europe may serve as an evidence-based tool to be implemented in practice and education. However, the variability in human and material resources as well as the different cultural contexts should be considered during this process. • Radiographers' awareness of their professional identity and enhancing multiprofessional cooperation in mammography. • Radiographers' responsibilities regarding image quality (IQ) and optimal breast imaging performance. • Patient-centred mammography services focusing on the psychosocial needs of the patient. • Challenges: positioning, QC-testing, IQ-assessment, optimization of breast compression, communication, teamwork, and patient-centred care. • Introduction of evidence-based guidelines in Europe to harmonize mammography practice and education.

  18. Ultra-Portable Smartphone Controlled Integrated Digital Microfluidic System in a 3D-Printed Modular Assembly

    Directory of Open Access Journals (Sweden)

    Mohamed Yafia

    2015-09-01

    Full Text Available Portable sensors and biomedical devices are influenced by the recent advances in microfluidics technologies, compact fabrication techniques, improved detection limits and enhanced analysis capabilities. This paper reports the development of an integrated ultraportable, low-cost, and modular digital microfluidic (DMF system and its successful integration with a smartphone used as a high-level controller and post processing station. Low power and cost effective electronic circuits are designed to generate the high voltages required for DMF operations in both open and closed configurations (from 100 to 800 V. The smartphone in turn commands a microcontroller that manipulate the voltage signals required for droplet actuation in the DMF chip and communicates wirelessly with the microcontroller via Bluetooth module. Moreover, the smartphone acts as a detection and image analysis station with an attached microscopic lens. The holder assembly is fabricated using three-dimensional (3D printing technology to facilitate rapid prototyping. The holder features a modular design that enables convenient attachment/detachment of a variety of DMF chips to/from an electrical busbar. The electrical circuits, controller and communication system are designed to minimize the power consumption in order to run the device on small lithium ion batteries. Successful controlled DMF operations and a basic colorimetric assay using the smartphone are demonstrated.

  19. INTEGRATION CHALLENGES OF UNIVERSITY AND INFORMATION MANAGEMENT SYSTEM (UIMS TO MOODLE

    Directory of Open Access Journals (Sweden)

    Jyldyzbek J. Jakshylykov

    2016-06-01

    Full Text Available Introduction: in 2006 an International Ataturk Ala-Too University (IAAU began to adopt internationally recognised Bologna system, which was initiated by the Ministry of Science and Education of Kyrgyz Republic because of problems of managerial and educational problems at universities in Kyrgyzstan. Consequently, IAAU had to improve its information and grading system and created University Information and Manage¬ment System (UIMS, which was developed by the university professional team including the author. At the same time, the university began to apply a Moodle software, which delivers open source management system programs, in order to appropriately manage teaching proc esses and manage courses online. Materials and Methods: the methodological basis of the research are descriptive method, analysis, and comparison. Results: however, the IAAU faced some challenged issues in the application of the two innovation, which was the integration challenges of those Moodle and UIMS. Hence, the main purpose of this study is to demonstrate benefits of Moodle and UIMS linking challenges. at first, this paper informs Moodle functions, features, advantages and disadvantages in a shortly manner and UIMS management features and primary functions, which included six fundamentally crucial processes with some graphical representations. In addition, the analysis and methodologies of two systems through identifying advantages and disadvantages for the possible integ ration. Discussion and Conclusions: at the end, some challenged issues were identified from analysis results, also Moodle and UIMS benefits were demonstrated in the International Ataturk Ala-Too University.

  20. The Integration of Energy Efficiency, Renewable Energy, DemandResponse and Climate Change: Challenges and Opportunities for Evaluatorsand Planners

    Energy Technology Data Exchange (ETDEWEB)

    Vine, Edward

    2007-05-29

    This paper explores the feasibility of integrating energyefficiency program evaluation with the emerging need for the evaluationof programs from different "energy cultures" (demand response, renewableenergy, and climate change). The paper reviews key features andinformation needs of the energy cultures and critically reviews theopportunities and challenges associated with integrating these withenergy efficiency program evaluation. There is a need to integrate thedifferent policy arenas where energy efficiency, demand response, andclimate change programs are developed, and there are positive signs thatthis integration is starting to occur.

  1. Challenges faced by international nurses when migrating: an integrative literature review.

    Science.gov (United States)

    Pung, L-X; Goh, Y-S

    2017-03-01

    Results from this literature review were used to identify the challenges faced by international nurses in their host countries following migration. The increasing strain of nursing shortages in the healthcare system has led to the recruitment of international nurses among many countries. However, following migration, international nurses are faced with challenges that may result in poor integration with their host countries. Using Cooper's five stages for integrative research reviews, a literature search was conducted across seven databases using a PRISMA search strategy. Additional manual searches were also conducted on the end-references of the retrieved articles. The authors then independently reviewed the selected articles using the Joanna Briggs Institute appraisal form to extract and generate the themes for the review. Twenty-four articles were selected for the review. The themes generated included: (i) difficulty orientating; (ii) a longing for what is missing; (iii) professional development and devaluing; (iv) communication barriers; (v) discrimination and marginalization; (vi) personal and professional differences; and (vii) a meaningful support system. By identifying the challenges faced by international nurses, interventions that ensure equal treatment (e.g. multifaceted transition programmes and culturally sensitive 'buddy' systems) can be implemented to help international nurses adapt to their new environments. Adequate communication can be achieved by encouraging international nurses to speak English and learn the colloquial language and non-verbal behaviours used by native nurses. With good integration international nurses may be able to reach their full career potential as professional nurses in their host countries. The adaptation process is a dynamic process that requires effort from both international and native nurses. Thus, any strategies that are developed and implemented must be multifaceted. © 2016 International Council of Nurses.

  2. Self-assembly as a design tool for the integration of photonic structures into excitonic solar cells

    KAUST Repository

    Guldin, S.; Docampo, P.; Hü ttner, S.; Kohn, P.; Stefik, M.; Snaith, H. J.; Wiesner, U.; Steiner, U.

    2011-01-01

    ) into dye-sensitized solar cells (DSCs). In both cases, the self-assembly of soft matter plays a key role in the fabrication process of the TiO2 electrode. One approach relies on a combination of colloidal self-assembly and the self-assembly of block

  3. Integrating chemical and biological status assessment: Assembling lines of evidence for the evaluation of river ecosystem risk

    International Nuclear Information System (INIS)

    Munoz Gracia, Isabel; Sabater, Sergi

    2014-01-01

    This paper describes various approaches to evaluating ecological risk in rivers affected by multiple chemical stressors, with emphasis on biofilm and invertebrate community responses. Metrics should be considered as different lines of evidence that, when weighted, form an advanced weight of evidence approach to establishing the environmental risk on a basin scale. Combination of field surveys to obtain observational data of communities, in situ experiments, toxicological sediment tests and a good chemical description of the medium (water and sediment) helps give an integrative view of the chemical and biological state of a river ecosystem. The greater and more distinct the variables used, the greater is our ability to identify the effects of major stressors impairing communities. Weight of evidence is an integrative methodology for tackling the challenge of determining causal relations and applying this knowledge in the decision-making processes of river management.

  4. Smart integrated microsystems: the energy efficiency challenge (Conference Presentation) (Plenary Presentation)

    Science.gov (United States)

    Benini, Luca

    2017-06-01

    The "internet of everything" envisions trillions of connected objects loaded with high-bandwidth sensors requiring massive amounts of local signal processing, fusion, pattern extraction and classification. From the computational viewpoint, the challenge is formidable and can be addressed only by pushing computing fabrics toward massive parallelism and brain-like energy efficiency levels. CMOS technology can still take us a long way toward this goal, but technology scaling is losing steam. Energy efficiency improvement will increasingly hinge on architecture, circuits, design techniques such as heterogeneous 3D integration, mixed-signal preprocessing, event-based approximate computing and non-Von-Neumann architectures for scalable acceleration.

  5. Article Commentary: Integral Healthcare: The Benefits and Challenges of Integrating Complementary and Alternative Medicine with a Conventional Healthcare Practice

    Directory of Open Access Journals (Sweden)

    Christina L. Ross PhD

    2009-01-01

    Full Text Available Today's medicine is in the midst of an undeniable crisis. Calls to reform healthcare are in the forefront of economic and political discussions worldwide. Economic pressures reduce the amount of time physicians can spend with patients contributing to burnout among medical staff and endangering the patient iatrogenically. Politicians are getting involved as the public is calling for more affordable healthcare. A new paradigm must be embraced in order to address all aspects of this dilemma. It is clear that science and technology have resulted in vastly improved understanding, diagnosis, and treatment of disease, but the emphasis on science and technology to the exclusion of other elements of healing has also served to limit the development of a model that humanizes healthcare. The healing of a patient must include more than the biology and chemistry of their physical body; by necessity, it must include the mental, emotional and spiritual aspects. Because of these challenges, the development of an integral healthcare system that is rooted in appropriate regulation and supported by rigorous scientific evidence is the direction that many models of integrative healthcare are moving towards in the 21st century.

  6. Digital Libraries: The Challenge of Integrating Instagram with a Taxonomy for Content Management

    Directory of Open Access Journals (Sweden)

    Simona Ibba

    2016-05-01

    Full Text Available Interoperability and social implication are two current challenges in the digital library (DL context. To resolve the problem of interoperability, our work aims to find a relationship between the main metadata schemas. In particular, we want to formalize knowledge through the creation of a metadata taxonomy built with the analysis and the integration of existing schemas associated with DLs. We developed a method to integrate and combine Instagram metadata and hashtags. The final result is a taxonomy, which provides innovative metadata with respect to the classification of resources, as images of Instagram and the user-generated content, that play a primary role in the context of modern DLs. The possibility of Instagram to localize the photos inserted by users allows us to interpret the most relevant and interesting informative content for a specific user type and in a specific location and to improve access, visibility and searching of library content.

  7. Ultrafast-laser-inscribed 3D integrated photonics: challenges and emerging applications

    Directory of Open Access Journals (Sweden)

    Gross S.

    2015-11-01

    Full Text Available Since the discovery that tightly focused femtosecond laser pulses can induce a highly localised and permanent refractive index modification in a large number of transparent dielectrics, the technique of ultrafast laser inscription has received great attention from a wide range of applications. In particular, the capability to create three-dimensional optical waveguide circuits has opened up new opportunities for integrated photonics that would not have been possible with traditional planar fabrication techniques because it enables full access to the many degrees of freedom in a photon. This paper reviews the basic techniques and technological challenges of 3D integrated photonics fabricated using ultrafast laser inscription as well as reviews the most recent progress in the fields of astrophotonics, optical communication, quantum photonics, emulation of quantum systems, optofluidics and sensing.

  8. Target Assembly Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Target Assembly Facility integrates new armor concepts into actual armored vehicles. Featuring the capability ofmachining and cutting radioactive materials, it...

  9. Challenges and Opportunities for Integrating Social Science Perspectives into Climate and Global Change Assessments

    Science.gov (United States)

    Larson, E. K.; Li, J.; Zycherman, A.

    2017-12-01

    Integration of social science into climate and global change assessments is fundamental for improving understanding of the drivers, impacts and vulnerability of climate change, and the social, cultural and behavioral challenges related to climate change responses. This requires disciplinary and interdisciplinary knowledge as well as integrational and translational tools for linking this knowledge with the natural and physical sciences. The USGCRP's Social Science Coordinating Committee (SSCC) is tasked with this challenge and is working to integrate relevant social, economic and behavioral knowledge into processes like sustained assessments. This presentation will discuss outcomes from a recent SSCC workshop, "Social Science Perspectives on Climate Change" and their applications to sustained assessments. The workshop brought academic social scientists from four disciplines - anthropology, sociology, geography and archaeology - together with federal scientists and program managers to discuss three major research areas relevant to the USGCRP and climate assessments: (1) innovative tools, methods, and analyses to clarify the interactions of human and natural systems under climate change, (2) understanding of factors contributing to differences in social vulnerability between and within communities under climate change, and (3) social science perspectives on drivers of global climate change. These disciplines, collectively, emphasize the need to consider socio-cultural, political, economic, geographic, and historic factors, and their dynamic interactions, to understand climate change drivers, social vulnerability, and mitigation and adaptation responses. They also highlight the importance of mixed quantitative and qualitative methods to explain impacts, vulnerability, and responses at different time and spatial scales. This presentation will focus on major contributions of the social sciences to climate and global change research. We will discuss future directions for

  10. Bringing Wellness to Schools: Opportunities and Challenges to Mental Health Integration in School Health Centers

    Science.gov (United States)

    Lai, Karen; Guo, Sisi; Ijadi-Maghsoodi, Roya; Puffer, Maryjane; Kataoka, Sheryl H.

    2016-01-01

    Objective School-based health centers (SBHCs) reduce mental health access-to-care barriers and improve educational outcomes for youth. This qualitative study evaluates the innovations and challenges of a unique network of SBHCs in a large, urban school district, as they attempt to integrate health, mental health, and educational services. Methods The 43 participants sampled included mental health providers, primary care providers, and care coordinators at 14 SBHCs. Semi-structured interviews with each participant were audio-recorded and transcribed. Themes were identified and coded using Atlas.ti 5.1, and collapsed into three domains: Operations, Partnership, and Engagement. Results Interviews revealed provider models ranging from single agencies offering both health and mental health services to co-located services. Sites with the Health Agency providing at least some mental health services reported more mental health screenings. Many sites utilized SBHC coordinators and coordination team meetings to facilitate relationships between schools and Health Agency and Community Mental Health Clinic providers. Partnership challenges included confidentiality policies and staff turnover. Participants also highlighted student and parent engagement, through culturally sensitive services, peer health advocates, and “drop-in” lunches. Conclusions Staffing and operational models are critical in the success of health-mental health-education integration. Among the provider models observed, the combined health and mental health provider model offered the most integrated services. Despite barriers, providers and schools have begun to implement novel solutions for operational problems and family engagement in mental health services. Implications for future SBHCs as an integrated model are described. PMID:27417895

  11. Analysis of metabolomic data: tools, current strategies and future challenges for omics data integration.

    Science.gov (United States)

    Cambiaghi, Alice; Ferrario, Manuela; Masseroli, Marco

    2017-05-01

    Metabolomics is a rapidly growing field consisting of the analysis of a large number of metabolites at a system scale. The two major goals of metabolomics are the identification of the metabolites characterizing each organism state and the measurement of their dynamics under different situations (e.g. pathological conditions, environmental factors). Knowledge about metabolites is crucial for the understanding of most cellular phenomena, but this information alone is not sufficient to gain a comprehensive view of all the biological processes involved. Integrated approaches combining metabolomics with transcriptomics and proteomics are thus required to obtain much deeper insights than any of these techniques alone. Although this information is available, multilevel integration of different 'omics' data is still a challenge. The handling, processing, analysis and integration of these data require specialized mathematical, statistical and bioinformatics tools, and several technical problems hampering a rapid progress in the field exist. Here, we review four main tools for number of users or provided features (MetaCoreTM, MetaboAnalyst, InCroMAP and 3Omics) out of the several available for metabolomic data analysis and integration with other 'omics' data, highlighting their strong and weak aspects; a number of related issues affecting data analysis and integration are also identified and discussed. Overall, we provide an objective description of how some of the main currently available software packages work, which may help the experimental practitioner in the choice of a robust pipeline for metabolomic data analysis and integration. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  12. Barriers and challenges in integration of anthroposophic medicine in supportive breast cancer care.

    Science.gov (United States)

    Ben-Arye, Eran; Schiff, Elad; Levy, Moti; Raz, Orit Gressel; Barak, Yael; Bar-Sela, Gil

    2013-01-01

    In the last decade, more and more oncology centers are challenged with complementary medicine (CM) integration within supportive breast cancer care. Quality of life (QOL) improvement and attenuation of oncology treatment side effects are the core objectives of integrative CM programs in cancer care. Yet, limited research is available on the use of specific CM modalities in an integrative setting and on cancer patients' compliance with CM consultation. Studies are especially warranted to view the clinical application of researched CM modalities, such as anthroposophic medicine (AM), a unique CM modality oriented to cancer supportive care. Our objective was to characterize consultation patterns provided by physicians trained in CM following oncology health-care practitioners' referral of patients receiving chemotherapy. We aimed to identify characteristics of patients who consulted with AM and to explore patients' compliance to AM treatment. Of the 341 patients consulted with integrative physicians, 138 were diagnosed with breast cancer. Following integrative physician consultation, 56 patients were advised about AM treatment and 285 about other CM modalities. Logistic multivariate regression model found that, compared with patients receiving non-anthroposophic CM, the AM group had significantly greater rates of previous CM use [EXP(B) = 3.25, 95% C.I. 1.64-6.29, p = 0.001] and higher rates of cancer recurrence at baseline (p = 0.038). Most AM users (71.4%) used a single AM modality, such as mistletoe (viscum album) injections, oral AM supplements, or music therapy. Compliance with AM modalities following physician recommendation ranged from 44% to 71% of patients. We conclude that AM treatment provided within the integrative oncology setting is feasible based on compliance assessment. Other studies are warranted to explore the effectiveness of AM in improving patients' QOL during chemotherapy.

  13. Integration of community health workers into health systems in developing countries: Opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Collins Otieno Asweto

    2016-02-01

    Full Text Available Background: Developing countries have the potential to reach vulnerable and underserved populations marginalized by the country’s health care systems by way of community health workers (CHWs. It is imperative that health care systems focus on improving access to quality continuous primary care through the use of CHWs while paying attention to the factors that impact on CHWs and their effectiveness. Objective: To explore the possible opportunities and challenges of integrating CHWs into the health care systems of developing countries. Methods: Six databases were examined for quantitative, qualitative, and mixed-methods studies that included the integration of CHWs, their motivation and supervision, and CHW policy making and implementation in developing countries. Thirty-three studies met the inclusion criteria and were double read to extract data relevant to the context of CHW programs. Thematic coding was conducted and evidence on the main categories of contextual factors influencing integration of CHWs into the health system was synthesized. Results: CHWs are an effective and appropriate element of a health care team and can assist in addressing health disparities and social determinants of health. Important facilitators of integration of CHWs into health care teams are support from other health workers and inclusion of CHWs in case management meetings. Sustainable integration of CHWs into the health care system requires the formulation and implementation of polices that support their work, as well as financial and nonfinancial incentives, motivation, collaborative and supportive supervision, and a manageable workload. Conclusions: For sustainable integration of CHWs into health care systems, high-performing health systems with sound governance, adequate financing, well-organized service delivery, and adequate supplies and equipment are essential. Similarly, competent communities could contribute to better CHW performance through sound

  14. Towards an integrated approach to emergency management: interdisciplinary challenges for research and practice

    Directory of Open Access Journals (Sweden)

    Christian Webersik

    2015-10-01

    Full Text Available This article presents an interdisciplinary vision for large-scale integrated emergency management that has been inspired by the transition from platform centric to inte-grated operations in the oil and gas fields, which uses remote emergency control centres collaborating virtually with local responders. The article discusses some of the most salient research challenges for integrated emergency management, including the role of mobile technology, human-centred sensing, citizen participation and social media, and the socio-cultural determinants of disaster management. The purpose of this article is to frame an integrated emergency management approach that adopts a multi-disciplinary approach, including human computer interaction, information systems, computer science, development studies and organization science employing different methodologies.Most importantly, we need to better understand the socio-cultural determinants of how people prepare to, respond and perceive disasters, in order to evaluate whether and what kind of information and communication technology (ICT support is appropriate. There is need for more research as to why in some regions local people ignore official orders to evacuate, and rather follow the advice of local leaders, elders or religious leaders. In other instances, disasters are seen as 'acts of God' thus shaping disaster preparedness and response.

  15. Development of Geometry Optimization Methodology with In-house CFD code, and Challenge in Applying to Fuel Assembly

    International Nuclear Information System (INIS)

    Jeong, J. H.; Lee, K. L.

    2016-01-01

    The wire spacer has important roles to avoid collisions between adjacent rods, to mitigate a vortex induced vibration, and to enhance convective heat transfer by wire spacer induced secondary flow. Many experimental and numerical works has been conducted to understand the thermal-hydraulics of the wire-wrapped fuel bundles. There has been enormous growth in computing capability. Recently, a huge increase of computer power allows to three-dimensional simulation of thermal-hydraulics of wire-wrapped fuel bundles. In this study, the geometry optimization methodology with RANS based in-house CFD (Computational Fluid Dynamics) code has been successfully developed in air condition. In order to apply the developed methodology to fuel assembly, GGI (General Grid Interface) function is developed for in-house CFD code. Furthermore, three-dimensional flow fields calculated with in-house CFD code are compared with those calculated with general purpose commercial CFD solver, CFX. The geometry optimization methodology with RANS based in-house CFD code has been successfully developed in air condition. In order to apply the developed methodology to fuel assembly, GGI function is developed for in-house CFD code as same as CFX. Even though both analyses are conducted with same computational meshes, numerical error due to GGI function locally occurred in only CFX solver around rod surface and boundary region between inner fluid region and outer fluid region.

  16. Electron transfer dynamics across self-assembled N-(2-mercaptoethyl) octadecanamide/mycolic acid layers: impedimetric insights into the structural integrity and interaction with anti-mycolic acid antibodies

    CSIR Research Space (South Africa)

    Ozoemena, KI

    2010-01-01

    Full Text Available The integrity and properties of mycolic acid (MA) antigens integrated into a self-assembled monolayer (SAM) of N-(2-mercaptoethyl)octadecanamide, (MEODA), on a gold electrode have been interrogated using cyclic voltammetry (CV) and electrochemical...

  17. The integration of renewable energy in the French electricity system: what challenges for optimization?

    International Nuclear Information System (INIS)

    Mathieu, Mathilde; Ruedinger, Andreas; Pescia, Dimitri

    2016-01-01

    Based on research reports and dialogue through expert seminars organized by IDDRI and Agora Energiewende in 2015, this Working Paper proposes a synthesis of the main challenges for the integration of renewable energies using an analysis of the electricity system and its potential for optimization over different time frames: the potential evolution of electricity systems at the regional and national levels in France between now and 2030; an analysis of the needs and options for flexibility services beyond production systems; the potential for optimization of instruments to encourage short-term integration in line with changes in regulation regarding RES support schemes. Achieving the targets for renewable energy development (RES-E) in France (40% share of the electricity consumption) and in Europe (approximately 50%) by 2030 poses new integration challenges. The successful transformation of the electricity system based on a significant renewable component requires a systemic approach which takes into account: the evolution of demand and supply (for electricity and all energy), the interactions and competition between flexibility options for system stabilization (interconnections, active demand-side management, storage), the development of relevant infrastructure and articulation between the technical system and market design. A forward-looking analysis of electricity systems helps to assess this increase in flexibility requirements while identifying several optimization options to facilitate RES integration, starting with regional coordination. France already has a flexible electricity system, thanks notably to its hydro potential. Even so, its evolution towards 40% RES by 2030 calls for some strategic choices. On the one hand, drawing up a long-term trajectory for the evolution of electricity demand - in terms of volume as well as the nature of needs addressed - seems essential to bring coherence to the evolution of the technology portfolio and to increase the

  18. Toward allotetraploid cotton genome assembly: integration of a high-density molecular genetic linkage map with DNA sequence information

    Science.gov (United States)

    2012-01-01

    Background Cotton is the world’s most important natural textile fiber and a significant oilseed crop. Decoding cotton genomes will provide the ultimate reference and resource for research and utilization of the species. Integration of high-density genetic maps with genomic sequence information will largely accelerate the process of whole-genome assembly in cotton. Results In this paper, we update a high-density interspecific genetic linkage map of allotetraploid cultivated cotton. An additional 1,167 marker loci have been added to our previously published map of 2,247 loci. Three new marker types, InDel (insertion-deletion) and SNP (single nucleotide polymorphism) developed from gene information, and REMAP (retrotransposon-microsatellite amplified polymorphism), were used to increase map density. The updated map consists of 3,414 loci in 26 linkage groups covering 3,667.62 cM with an average inter-locus distance of 1.08 cM. Furthermore, genome-wide sequence analysis was finished using 3,324 informative sequence-based markers and publicly-available Gossypium DNA sequence information. A total of 413,113 EST and 195 BAC sequences were physically anchored and clustered by 3,324 sequence-based markers. Of these, 14,243 ESTs and 188 BACs from different species of Gossypium were clustered and specifically anchored to the high-density genetic map. A total of 2,748 candidate unigenes from 2,111 ESTs clusters and 63 BACs were mined for functional annotation and classification. The 337 ESTs/genes related to fiber quality traits were integrated with 132 previously reported cotton fiber quality quantitative trait loci, which demonstrated the important roles in fiber quality of these genes. Higher-level sequence conservation between different cotton species and between the A- and D-subgenomes in tetraploid cotton was found, indicating a common evolutionary origin for orthologous and paralogous loci in Gossypium. Conclusion This study will serve as a valuable genomic resource

  19. Integrating Mercury Science and Policy in the Marine Context: Challenges and Opportunities

    Science.gov (United States)

    Lambert, Kathleen F.; Evers, David C.; Warner, Kimberly A.; King, Susannah L.; Selin, Noelle E.

    2014-01-01

    Mercury is a global pollutant and presents policy challenges at local, regional, and global scales. Mercury poses risks to the health of people, fish, and wildlife exposed to elevated levels of mercury, most commonly from the consumption of methylmercury in marine and estuarine fish. The patchwork of current mercury abatement efforts limits the effectiveness of national and multi-national policies. This paper provides an overview of the major policy challenges and opportunities related to mercury in coastal and marine environments, and highlights science and policy linkages of the past several decades. The U.S. policy examples explored here point to the need for a full life cycle approach to mercury policy with a focus on source reduction and increased attention to: (1) the transboundary movement of mercury in air, water, and biota; (2) the coordination of policy efforts across multiple environmental media; (3) the cross-cutting issues related to pollutant interactions, mitigation of legacy sources, and adaptation to elevated mercury via improved communication efforts; and (4) the integration of recent research on human and ecological health effects into benefits analyses for regulatory purposes. Stronger science and policy integration will benefit national and international efforts to prevent, control, and minimize exposure to methylmercury. PMID:22901766

  20. Overcoming communication challenges in integrative supportive cancer care: The integrative physician, the psycho-oncologist, and the patient.

    Science.gov (United States)

    Ben-Arye, Eran; Shavit, Efrat; Wiental, Haya; Schiff, Elad; Agour, Olga; Samuels, Noah

    2016-12-01

    Complementary/integrative medicine (CIM) services are increasingly being integrated into conventional supportive cancer care, presenting a number of challenges to communication between healthcare professionals (HCPs). The purpose of the present study was to explore the impact of the communication between integrative physicians (IPs) trained in CIM and social workers (SWs) working as psycho-oncologists in the same oncology setting. We examine whether IP-SW communication correlates with the number of patient-SW sessions, as provided within the oncology department. SW-IP communication, defined as a summary of the IP consultation sent to the patient's SW, was compared to SW-patient communication, defined as the number of psycho-oncology treatment sessions. Of 344 patients referred by their oncology HCP for IP consultation, 91 were referred by an SW and 253 by an oncologist or nurse. IP-to-SW summaries were provided for 150 patients referred by a non-SW HCP (43.6%), and for 91 of SW-referred patients (26.5%). In all, 32 patients referred to the IP had no psycho-oncology interaction with an SW; 58 only one meeting; and 254 with ≥2 interactions, with 119 having >6 sessions. SW-patient interactions were greater with higher rates of IP-SW communication, for both patients referred by an SW (79.1%) and those referred by a non-SW HCP (77.3%) when compared to patients for whom no summary was provided (64.1%; p= 0.02). A greater level of IP-SW communication, measured by the provision of an IP summary to the patient's SW, was found to correlate with a higher rate of SW-patient interactions. The use of a structured two-way referral-summary between IPs and SWs has the potential to advance the SW-patient psycho-oncology interaction, within an integrative supportive cancer care setting. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Integrating adaptive management and ecosystem services concepts to improve natural resource management: Challenges and opportunities

    Science.gov (United States)

    Epanchin-Niell, Rebecca S.; Boyd, James W.; Macauley, Molly K.; Scarlett, Lynn; Shapiro, Carl D.; Williams, Byron K.

    2018-05-07

    resource systems, both must confront the analytical challenges of systems modeling—in terms of complexity, dynamics, and uncertainty.Given this affinity, the integration of ecosystem services analysis and adaptive management poses few conceptual hurdles. In this report, we synthesize discussions from two workshops that considered ways in which adaptive management approaches and ecosystem service concepts may be complementary, such that integrating them into a common framework may lead to improved natural resource management outcomes. Although the literature on adaptive management and ecosystem services is vast and growing, the report focuses specifically on the integration of these two concepts rather than aiming to provide new definitions or an indepth review or primer of the concepts individually.Key issues considered include the bidirectional links between adaptive decision making and ecosystem services, as well as the potential benefits and inevitable challenges arising in the development and use of an integrated framework. Specifically, the workshops addressed the following questions:How can application of ecosystem service analysis within an adaptive decision process improve the outcomes of management and advance understanding of ecosystem service identification, production, and valuation?How can these concepts be integrated in concept and practice?What are the constraints and challenges to integrating adaptive management and ecosystem services?And, should the integration of these concepts be moved forward to wider application—and if so, how?

  2. Electrostatic Self-Assembly Enabling Integrated Bulk and Interfacial Sodium Storage in 3D Titania-Graphene Hybrid

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Gui-Liang [Chemical; Xiao, Lisong [Center; Sheng, Tian [Collaborative; Liu, Jianzhao [Chemical; Hu, Yi-Xin [Chemical; Department; Ma, Tianyuan [Chemical; Amine, Rachid [Materials; Xie, Yingying [Chemical; Zhang, Xiaoyi [X-ray Science; Liu, Yuzi [Nanoscience; Ren, Yang [X-ray Science; Sun, Cheng-Jun [X-ray Science; Heald, Steve M. [X-ray Science; Kovacevic, Jasmina [Center; Sehlleier, Yee Hwa [Center; Schulz, Christof [Center; Mattis, Wenjuan Liu [Microvast Power Solutions, 12603; Sun, Shi-Gang [Collaborative; Wiggers, Hartmut [Center; Chen, Zonghai [Chemical; Amine, Khalil [Chemical

    2017-12-15

    Room temperature sodium-ion batteries have attracted increased attention for energy storage due to the natural abundance of sodium. However, it remains a huge challenge to develop versatile electrode materials with favorable properties, which requires smart structure design and good mechanistic understanding. Herein, we reported a general and scalable approach to synthesize 3D titania-graphene hybrid via electrostatic-interaction-induced self-assembly. Synchrotron X-ray probe, transmission electron microscopy and computational modeling revealed that the strong interaction between Titania and graphene through comparably strong van-der-Waals forces not only facilitates bulk Na+ intercalation but also enhances the interfacial sodium storage. As a result, the titania-graphene hybrid exhibits exceptional long-term cycle stability up to 5000 cycles, and ultrahigh rate capability up to 20 C for sodium storage. Furthermore, density function theory calculation indicated that the interfacial Li+, K+, Mg2+ and Al3+ storage can be enhanced as well. The proposed general strategy opens up new avenues to create versatile materials for advanced battery systems.

  3. Electrostatic Self-Assembly Enabling Integrated Bulk and Interfacial Sodium Storage in 3D Titania-Graphene Hybrid.

    Science.gov (United States)

    Xu, Gui-Liang; Xiao, Lisong; Sheng, Tian; Liu, Jianzhao; Hu, Yi-Xin; Ma, Tianyuan; Amine, Rachid; Xie, Yingying; Zhang, Xiaoyi; Liu, Yuzi; Ren, Yang; Sun, Cheng-Jun; Heald, Steve M; Kovacevic, Jasmina; Sehlleier, Yee Hwa; Schulz, Christof; Mattis, Wenjuan Liu; Sun, Shi-Gang; Wiggers, Hartmut; Chen, Zonghai; Amine, Khalil

    2018-01-10

    Room-temperature sodium-ion batteries have attracted increased attention for energy storage due to the natural abundance of sodium. However, it remains a huge challenge to develop versatile electrode materials with favorable properties, which requires smart structure design and good mechanistic understanding. Herein, we reported a general and scalable approach to synthesize three-dimensional (3D) titania-graphene hybrid via electrostatic-interaction-induced self-assembly. Synchrotron X-ray probe, transmission electron microscopy, and computational modeling revealed that the strong interaction between titania and graphene through comparably strong van der Waals forces not only facilitates bulk Na + intercalation but also enhances the interfacial sodium storage. As a result, the titania-graphene hybrid exhibits exceptional long-term cycle stability up to 5000 cycles, and ultrahigh rate capability up to 20 C for sodium storage. Furthermore, density function theory calculation indicated that the interfacial Li + , K + , Mg 2+, and Al 3+ storage can be enhanced as well. The proposed general strategy opens up new avenues to create versatile materials for advanced battery systems.

  4. Implementation of the Integrated Management of Childhood Illnesses strategy: challenges and recommendations in Botswana.

    Science.gov (United States)

    Mupara, Lucia U; Lubbe, Johanna C

    2016-01-01

    Under-five mortality has been a major public health challenge from time immemorial. In response to this challenge, the World Health Organization and the United Nations Children's Fund developed the Integrated Management of Childhood Illnesses (IMCI) strategy and presented it to the whole world as a key approach to reduce child morbidity and mortality. Botswana started to implement the IMCI strategy in 1998. Reductions in the under-five mortality rate (U5MR) have been documented, although the reduction is not on par with the expected Millennium Development Goal 4 predictions. A quantitative study was done to identify the problems IMCI implementers face when tending children under 5 years in the Gaborone Health District of Botswana. The study population was made up of all the IMCI-trained and registered nurses, and systematic sampling was used to randomly select study participants. Questionnaires were used to collect data. The study findings indicated challenges related to low training coverage, health systems, and the unique features of the IMCI strategy. The comprehensive implementation of the IMCI strategy has the potential to significantly influence the U5MR in Botswana.

  5. Implementation of the Integrated Management of Childhood Illnesses strategy: challenges and recommendations in Botswana

    Directory of Open Access Journals (Sweden)

    Lucia U. Mupara

    2016-02-01

    Full Text Available Background: Under-five mortality has been a major public health challenge from time immemorial. In response to this challenge, the World Health Organization and the United Nations Children's Fund developed the Integrated Management of Childhood Illnesses (IMCI strategy and presented it to the whole world as a key approach to reduce child morbidity and mortality. Botswana started to implement the IMCI strategy in 1998. Reductions in the under-five mortality rate (U5MR have been documented, although the reduction is not on par with the expected Millennium Development Goal 4 predictions. Design: A quantitative study was done to identify the problems IMCI implementers face when tending children under 5 years in the Gaborone Health District of Botswana. The study population was made up of all the IMCI-trained and registered nurses, and systematic sampling was used to randomly select study participants. Questionnaires were used to collect data. Results: The study findings indicated challenges related to low training coverage, health systems, and the unique features of the IMCI strategy. Conclusions: The comprehensive implementation of the IMCI strategy has the potential to significantly influence the U5MR in Botswana.

  6. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.

    Science.gov (United States)

    van Os, Jim; Rutten, Bart P; Myin-Germeys, Inez; Delespaul, Philippe; Viechtbauer, Wolfgang; van Zelst, Catherine; Bruggeman, Richard; Reininghaus, Ulrich; Morgan, Craig; Murray, Robin M; Di Forti, Marta; McGuire, Philip; Valmaggia, Lucia R; Kempton, Matthew J; Gayer-Anderson, Charlotte; Hubbard, Kathryn; Beards, Stephanie; Stilo, Simona A; Onyejiaka, Adanna; Bourque, Francois; Modinos, Gemma; Tognin, Stefania; Calem, Maria; O'Donovan, Michael C; Owen, Michael J; Holmans, Peter; Williams, Nigel; Craddock, Nicholas; Richards, Alexander; Humphreys, Isla; Meyer-Lindenberg, Andreas; Leweke, F Markus; Tost, Heike; Akdeniz, Ceren; Rohleder, Cathrin; Bumb, J Malte; Schwarz, Emanuel; Alptekin, Köksal; Üçok, Alp; Saka, Meram Can; Atbaşoğlu, E Cem; Gülöksüz, Sinan; Gumus-Akay, Guvem; Cihan, Burçin; Karadağ, Hasan; Soygür, Haldan; Cankurtaran, Eylem Şahin; Ulusoy, Semra; Akdede, Berna; Binbay, Tolga; Ayer, Ahmet; Noyan, Handan; Karadayı, Gülşah; Akturan, Elçin; Ulaş, Halis; Arango, Celso; Parellada, Mara; Bernardo, Miguel; Sanjuán, Julio; Bobes, Julio; Arrojo, Manuel; Santos, Jose Luis; Cuadrado, Pedro; Rodríguez Solano, José Juan; Carracedo, Angel; García Bernardo, Enrique; Roldán, Laura; López, Gonzalo; Cabrera, Bibiana; Cruz, Sabrina; Díaz Mesa, Eva Ma; Pouso, María; Jiménez, Estela; Sánchez, Teresa; Rapado, Marta; González, Emiliano; Martínez, Covadonga; Sánchez, Emilio; Olmeda, Ma Soledad; de Haan, Lieuwe; Velthorst, Eva; van der Gaag, Mark; Selten, Jean-Paul; van Dam, Daniella; van der Ven, Elsje; van der Meer, Floor; Messchaert, Elles; Kraan, Tamar; Burger, Nadine; Leboyer, Marion; Szoke, Andrei; Schürhoff, Franck; Llorca, Pierre-Michel; Jamain, Stéphane; Tortelli, Andrea; Frijda, Flora; Vilain, Jeanne; Galliot, Anne-Marie; Baudin, Grégoire; Ferchiou, Aziz; Richard, Jean-Romain; Bulzacka, Ewa; Charpeaud, Thomas; Tronche, Anne-Marie; De Hert, Marc; van Winkel, Ruud; Decoster, Jeroen; Derom, Catherine; Thiery, Evert; Stefanis, Nikos C; Sachs, Gabriele; Aschauer, Harald; Lasser, Iris; Winklbaur, Bernadette; Schlögelhofer, Monika; Riecher-Rössler, Anita; Borgwardt, Stefan; Walter, Anna; Harrisberger, Fabienne; Smieskova, Renata; Rapp, Charlotte; Ittig, Sarah; Soguel-dit-Piquard, Fabienne; Studerus, Erich; Klosterkötter, Joachim; Ruhrmann, Stephan; Paruch, Julia; Julkowski, Dominika; Hilboll, Desiree; Sham, Pak C; Cherny, Stacey S; Chen, Eric Y H; Campbell, Desmond D; Li, Miaoxin; Romeo-Casabona, Carlos María; Emaldi Cirión, Aitziber; Urruela Mora, Asier; Jones, Peter; Kirkbride, James; Cannon, Mary; Rujescu, Dan; Tarricone, Ilaria; Berardi, Domenico; Bonora, Elena; Seri, Marco; Marcacci, Thomas; Chiri, Luigi; Chierzi, Federico; Storbini, Viviana; Braca, Mauro; Minenna, Maria Gabriella; Donegani, Ivonne; Fioritti, Angelo; La Barbera, Daniele; La Cascia, Caterina Erika; Mulè, Alice; Sideli, Lucia; Sartorio, Rachele; Ferraro, Laura; Tripoli, Giada; Seminerio, Fabio; Marinaro, Anna Maria; McGorry, Patrick; Nelson, Barnaby; Amminger, G Paul; Pantelis, Christos; Menezes, Paulo R; Del-Ben, Cristina M; Gallo Tenan, Silvia H; Shuhama, Rosana; Ruggeri, Mirella; Tosato, Sarah; Lasalvia, Antonio; Bonetto, Chiara; Ira, Elisa; Nordentoft, Merete; Krebs, Marie-Odile; Barrantes-Vidal, Neus; Cristóbal, Paula; Kwapil, Thomas R; Brietzke, Elisa; Bressan, Rodrigo A; Gadelha, Ary; Maric, Nadja P; Andric, Sanja; Mihaljevic, Marina; Mirjanic, Tijana

    2014-07-01

    Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  7. Challenges in process integration of catalytic DC plasma synthesis of vertically aligned carbon nanofibres

    International Nuclear Information System (INIS)

    Melechko, Anatoli V; Pearce, Ryan C; Hensley, Dale K; Simpson, Michael L; McKnight, Timothy E

    2011-01-01

    The ability to synthesize free-standing, individual carbon nanofibres (CNFs) aligned perpendicularly to a substrate has enabled fabrication of a large array of devices with nanoscale functional elements, including electron field emission sources, electrochemical probes, neural interface arrays, scanning probes, gene delivery arrays and many others. This was made possible by development of a catalytic plasma process, with DC bias directing the alignment of nanofibres. Successful implementation of prototypical devices has uncovered numerous challenges in the integration of this synthesis process as one of the steps in device fabrication. This paper is dedicated to these engineering and fundamental difficulties that hinder further device development. Relatively high temperature for catalytic synthesis, electrical conductivity of the substrate to maintain DC discharge and other difficulties place restrictions on substrate material. Balancing non-catalytic carbon film deposition and substrate etching, non-uniformity of plasma due to growth of the high aspect ratio structures, plasma instabilities and other factors lead to challenges in controlling the plasma. Ultimately, controlling the atomistic processes at the catalyst nanoparticle (NP) and the behaviour of the NP is the central challenge of plasma nanosynthesis of vertically aligned CNFs.

  8. Challenges in integrating the concept of ecosystem services and values in landscape planning, management and decision making

    NARCIS (Netherlands)

    Groot, de R.S.; Alkemade, J.R.M.; Braat, L.; Hein, L.G.; Willemen, L.L.J.M.

    2010-01-01

    Despite the growing body of literature on ecosystem services, still many challenges remain to structurally integrate ecosystem services in landscape planning, management and design. This paper therefore aims to provide an overview of the challenges involved in applying ecosystem service assessment

  9. Political Leadership and Challenges of National Integration and Development in Nigeria: The Way Forward

    Directory of Open Access Journals (Sweden)

    Akinbi Joseph Olukayode

    2015-04-01

    Full Text Available Concrete and genuine national integration and development have been elusive in Nigeria, which has been a thing of serious concern to scholars. The study interrogates why true integration and meaningful development have been elusive in the country? This constitutes the key problem of the study. The historical method of research and analysis was employed in the study as the paper under discussion covers the past, the present and likely implications on the future of the country. The major findings in the paper revealed various factors or challenges as been responsible for this abysmal state of affairsand which Nigerian political leaders have been battling with. The paper examines some of these challenges which among others include: the elusiveness of a national leader, corruption and mismanagement of material and human resources, lack of proper accountability on the part of Nigerian political leaders, the crushing economic depression which manifested in high cost of living, poverty, mass unemployment and dissatisfaction among the citizenry, problems of democratic consolidation, the Niger Delta environmental crisis, religious crisis and the recent Boko Haram scourge which had proved intractable for Nigerian government. The implication of the totality of all these factors has the effect of partly contributing to Nigeria perambulating at the same spot or even dancing backward rather than progressing, thereby making stability, true nation building, national integration and development elusive to the Nigerian nation. Recommendations proffered towards curbing the problems in the paper include: the need to learn from history, the need for improved electioneering culture, declaration of assets by political leaders to enhance accountability, respect for the secularity of Nigeria, creation of jobs and putting in place of people oriented programmes and the need for re-orientation of both leaders and followers in Nigeria.

  10. Study of the Electrolytic Reduction of Uranium Oxide in LiCl-Li2O Molten Salts with an Integrated Cathode Assembly

    International Nuclear Information System (INIS)

    Park, Sung Bin; Seo, Chung Seok; Kang, Dae Seung; Kwon, Seon Gil; Park, Seong Won

    2005-01-01

    The electrolytic reduction of uranium oxide in a LiCl-Li 2 O molten salt system has been studied in a 10 g U 3 O 3 /batch-scale experimental apparatus with an integrated cathode assembly at 650 .deg. C. The integrated cathode assembly consists of an electric conductor, the uranium oxide to be reduced and the membrane for loading the uranium oxide. From the cyclic voltammograms for the LiCl-3 wt% Li 3 O system and the U 3 O 3 -LiCl-3 wt% Li 2 O system according to the materials of the membrane in the cathode assembly, the mechanisms of the predominant reduction reactions in the electrolytic reactor cell were to be understood; direct and indirect electrolytic reduction of uranium oxide. Direct and indirect electrolytic reductions have been performed with the integrated cathode assembly. Using the 325-mesh stainless steel screen the uranium oxide failed to be reduced to uranium metal by a direct and indirect electrolytic reduction because of a low current efficiency and with the porous magnesia membrane the uranium oxide was reduced successfully to uranium metal by an indirect electrolytic reduction because of a high current efficiency.

  11. Meeting CCS communication challenges head-on: Integrating communications, planning, risk assessment, and project management

    Science.gov (United States)

    Greenberg, S.; Gauvreau, L.; Hnottavange-Telleen, K.; Finley, R.; Marsteller, S.

    2011-01-01

    The Midwest Geological Sequestration Consortium, Schlumberger Carbon Services, and Archer Daniels Midland has implemented a comprehensive communications plan at the Illinois Basin - Decatur Project (IBDP), a one million metric tonne Carbon Capture and Storage project in Decatur, IL, USA funded by the U.S. Department of Energy's National Energy Technology Laboratory. The IBDP Communication Plan includes consortium information, funding and disclaimer citations, description of target audiences, media communications guidelines, paper and presentations guidelines, site visit information, crisis communication, on-site photography regulations, and other components. The creation, development, and implementation processes for the IBDP Communication Plan (the Plan) are shared in this paper. New communications challenges, such as how to address add-on research requests, data sharing and management, scope increase, and contract agreements have arisen since the Plan was completed in January 2009, resulting in development of new policies and procedures by project management. Integrating communications planning, risk assessment, and project management ensured that consistent, factual information was developed and incorporated into project planning, and constitutes the basis of public communications. Successful integration has allowed the IBDP to benefit from early identification and mitigation of the potential project risks, which allows more time to effectively deal with unknown and unidentified risks that may arise. Project risks and risks associated with public perception can be managed through careful planning and integration of communication strategies into project management and risk mitigation. ?? 2011 Published by Elsevier Ltd.

  12. Challenges and opportunities for more integrated regional food security policy in the Caribbean Community

    Directory of Open Access Journals (Sweden)

    Kristen Lowitt

    2016-01-01

    Full Text Available The Caribbean Community (CARICOM has recognized regional integration as an important development strategy for addressing the unique vulnerabilities of its member small island developing states (SIDS. Food security in the Caribbean is a fundamental social and ecological challenge in which the dynamics of regional integration are increasingly playing out. CARICOM members have subsequently identified a number of shared food security problems and have endorsed regional goals and approaches to address them; however, progress towards solutions has been slow. Recognizing that evidence-based studies on the potential factors limiting sustained progress are lacking, we undertook a comparative policy analysis to understand better the various approaches and framings of food security at national and regional levels with a view to assessing coherence. We identify considerable divergence in how regional and local policy institutions frame and approach food security problems in CARICOM and then identify ways through which the policy integration objectives for enhanced regional food security might be progressed, with a particular focus on social learning.

  13. Strategies for integrated analysis of genetic, epigenetic and gene expression variation in cancer: addressing the challenges

    Directory of Open Access Journals (Sweden)

    Louise Bruun Thingholm

    2016-02-01

    Full Text Available The development and progression of cancer, a collection of diseases with complex genetic architectures, is facilitated by the interplay of multiple etiological factors. This complexity challenges the traditional single-platform study design and calls for an integrated approach to data analysis. However, integration of heterogeneous measurements of biological variation is a non-trivial exercise due to the diversity of the human genome and the variety of output data formats and genome coverage obtained from the commonly used molecular platforms. This review article will provide an introduction to integration strategies used for analyzing genetic risk factors for cancer. We critically examine the ability of these strategies to handle the complexity of the human genome and also accommodate information about the biological and functional interactions between the elements that have been measured – making the assessment of disease risk against a composite genomic factor possible. The focus of this review is to provide an overview and introduction to the main strategies and to discuss where there is a need for further development.

  14. Integrated Payment And Delivery Models Offer Opportunities And Challenges For Residential Care Facilities.

    Science.gov (United States)

    Grabowski, David C; Caudry, Daryl J; Dean, Katie M; Stevenson, David G

    2015-10-01

    Under health care reform, new financing and delivery models are being piloted to integrate health and long-term care services for older adults. Programs using these models generally have not included residential care facilities. Instead, most of them have focused on long-term care recipients in the community or the nursing home. Our analyses indicate that individuals living in residential care facilities have similarly high rates of chronic illness and Medicare utilization when compared with matched individuals in the community and nursing home, and rates of functional dependency that fall between those of their counterparts in the other two settings. These results suggest that the residential care facility population could benefit greatly from models that coordinated health and long-term care services. However, few providers have invested in the infrastructure needed to support integrated delivery models. Challenges to greater care integration include the private-pay basis for residential care facility services, which precludes shared savings from reduced Medicare costs, and residents' preference for living in a home-like, noninstitutional environment. Project HOPE—The People-to-People Health Foundation, Inc.

  15. The Challenge of Integrating Renewable Generation in the Alberta Electricity Market

    Directory of Open Access Journals (Sweden)

    G. Kent Fellows

    2016-09-01

    Full Text Available Renewable electric generation is forecast to enjoy an increasing share of total capacity and supply regimes in the future. Alberta is no exception to this trend, having initiated policy incentives in response to calls for increasing the fraction of wind and solar energy available to the province over the next decade.1 This call is coming from various sectors including advocacy groups, the provincial government and some utilities. The University of Calgary’s School of Public Policy convened a roundtable discussion on Sept. 15, 2015. Given the wide-ranging aspects of increased renewables integration (for example the policy options, economic forces and engineering/technical issues the topic demands attention from a wide range of experts and stakeholders. To that end, we endeavoured to group expert panellists and representatives of utilities, public agencies, academe and consumer groups to consider the planning necessary to integrate new renewable capacity into the existing and future grid system in the province and its potential impact. The purpose of the roundtable was to facilitate and foster a knowledge exchange between interested and knowledgeable parties while also aggregating this knowledge into a more complete picture of the challenges and potential strategies associated with increased renewables integration in the Alberta electricity grid.

  16. Fuel cell integral bundle assembly including ceramic open end seal and vertical and horizontal thermal expansion control

    Science.gov (United States)

    Zafred, Paolo R [Murrysville, PA; Gillett, James E [Greensburg, PA

    2012-04-24

    A plurality of integral bundle assemblies contain a top portion with an inlet fuel plenum and a bottom portion containing a base support, the base supports a dense, ceramic air exhaust manifold having four supporting legs, the manifold is below and connects to air feed tubes located in a recuperator zone, the air feed tubes passing into the center of inverted, tubular, elongated, hollow electrically connected solid oxide fuel cells having an open end above a combustion zone into which the air feed tubes pass and a closed end near the inlet fuel plenum, where the open end of the fuel cells rest upon and within a separate combination ceramic seal and bundle support contained in a ceramic support casting, where at least one flexible cushion ceramic band seal located between the recuperator and fuel cells protects and controls horizontal thermal expansion, and where the fuel cells operate in the fuel cell mode and where the base support and bottom ceramic air exhaust manifolds carry from 85% to all of the weight of the generator.

  17. Interfaces and Integration of Medical Image Analysis Frameworks: Challenges and Opportunities.

    Science.gov (United States)

    Covington, Kelsie; McCreedy, Evan S; Chen, Min; Carass, Aaron; Aucoin, Nicole; Landman, Bennett A

    2010-05-25

    Clinical research with medical imaging typically involves large-scale data analysis with interdependent software toolsets tied together in a processing workflow. Numerous, complementary platforms are available, but these are not readily compatible in terms of workflows or data formats. Both image scientists and clinical investigators could benefit from using the framework which is a most natural fit to the specific problem at hand, but pragmatic choices often dictate that a compromise platform is used for collaboration. Manual merging of platforms through carefully tuned scripts has been effective, but exceptionally time consuming and is not feasible for large-scale integration efforts. Hence, the benefits of innovation are constrained by platform dependence. Removing this constraint via integration of algorithms from one framework into another is the focus of this work. We propose and demonstrate a light-weight interface system to expose parameters across platforms and provide seamless integration. In this initial effort, we focus on four platforms Medical Image Analysis and Visualization (MIPAV), Java Image Science Toolkit (JIST), command line tools, and 3D Slicer. We explore three case studies: (1) providing a system for MIPAV to expose internal algorithms and utilize these algorithms within JIST, (2) exposing JIST modules through self-documenting command line interface for inclusion in scripting environments, and (3) detecting and using JIST modules in 3D Slicer. We review the challenges and opportunities for light-weight software integration both within development language (e.g., Java in MIPAV and JIST) and across languages (e.g., C/C++ in 3D Slicer and shell in command line tools).

  18. 300 Area Integrated Field-Scale Subsurface Research Challenge (IFRC) Field Site Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Freshley, Mark D.

    2008-12-31

    Pacific Northwest National Laboratory (PNNL) has established the 300 Area Integrated Field-Scale Subsurface Research Challenge (300 Area IFRC) on the Hanford Site in southeastern Washington State for the U.S. Department of Energy’s (DOE) Office of Biological and Environmental Research (BER) within the Office of Science. The project is funded by the Environmental Remediation Sciences Division (ERSD). The purpose of the project is to conduct research at the 300 IFRC to investigate multi-scale mass transfer processes associated with a subsurface uranium plume impacting both the vadose zone and groundwater. The management approach for the 300 Area IFRC requires that a Field Site Management Plan be developed. This is an update of the plan to reflect the installation of the well network and other changes.

  19. Integrating Pharmacoproteomics into Early-Phase Clinical Development: State-of-the-Art, Challenges, and Recommendations

    Directory of Open Access Journals (Sweden)

    Savita Nandal

    2017-02-01

    Full Text Available Pharmacoproteomics is the study of disease-modifying and toxicity parameters associated with therapeutic drug administration, using analysis of quantitative and temporal changes to specific, predetermined, and select proteins, or to the proteome as a whole. Pharmacoproteomics is a rapidly evolving field, with progress in analytic technologies enabling processing of complex interactions of large number of unique proteins and effective use in clinical trials. Nevertheless, our analysis of clinicaltrials.gov and PubMed shows that the application of proteomics in early-phase clinical development is minimal and limited to few therapeutic areas, with oncology predominating. We review the history, technologies, current usage, challenges, and potential for future use, and conclude with recommendations for integration of pharmacoproteomic in early-phase drug development.

  20. Ethical Challenges when Interviewing Close Relatives Together – An Integrative Review

    DEFF Research Database (Denmark)

    Voltelen, Barbara; Konradsen, Hanne; Østergaard, Birte

    and search terms. Results In total 17 articles were located, 9 containing relevant information about dyadic interviewing, only dealing subtly with questions of ethics. Another 8 articles addressed both dyadic interviewing and ethical considerations. Findings were divided into three different themes......Background and purpose Interviewing two interrelated persons (or more) simultaneously might pose different ethical considerations than interviewing just one person. Such ethical considerations, however, remain largely undescribed in literature, challenging the researcher who wishes to conduct them....... The purpose of this study is to describe the special ethical perspectives concerning joint interviews with interrelated persons. Method An integrative review was performed. A search was conducted in Pub Med, Cinahl, Philosophers Index and Academic Search from 1980 -2014. Data corpus from the 17 articles...

  1. Nursing education challenges and solutions in Sub Saharan Africa: an integrative review.

    Science.gov (United States)

    Bvumbwe, Thokozani; Mtshali, Ntombifikile

    2018-01-01

    The Lancet Commission and the Global Health Workforce Alliance reported that professional education has generally not kept up the pace of health care challenges. Sub Saharan Africa needs an effective and efficient nursing education system to build an adequate, competent and relevant nursing workforce necessary for the achievement of Sustainable Development Goals. The Plan of Action for Scaling up Quality Nursing and Midwifery Education and Practice for the African Region 2012 - 2022 provided a framework for scale up of nurses and midwives. This integrative review examined literature on nursing education challenges and solutions in Sub Saharan Africa to inform development of a model for improving the quality, quantity and relevance of nursing education at local level. A search of PubMed, Medline on EBCSOhost and Google Scholar was conducted using key words: nursing education, challenges, solutions and/ or Africa. Published works from 2012 to 2016 were reviewed to explore reports about challenges and solution in nursing education in Sub Saharan Africa. Full texts of relevant studies were retrieved after reading the tittles and abstracts. Critical appraisal was undertaken and the findings of the relevant studies were analysed using thematic analysis. Twenty articles and five grey sources were included. Findings of the review generally supports World Health Organisation framework for transformative and scale up of health professions education. Six themes emerged; curriculum reforms, profession regulation, transformative teaching strategies, collaboration and partnership, capacity building and infrastructure and resources. Challenges and solutions in nursing education are common within countries. The review shows that massive investment by development partners is resulting in positive development of nursing education in Sub Saharan Africa. However, strategic leadership, networking and partnership to share expertise and best practices are critical. Sub Saharan Africa

  2. State of the Art and Challenges for Offshore Integrated Multi-Trophic Aquaculture (IMTA

    Directory of Open Access Journals (Sweden)

    Bela H. Buck

    2018-05-01

    Full Text Available By moving away from coastal waters and hence reducing pressure on nearshore ecosystems, offshore aquaculture can be seen as a possible step towards the large-scale expansion of marine food production. Integrated multi-trophic aquaculture (IMTA in nearshore water bodies has received increasing attention and could therefore play a role in the transfer of aquaculture operations to offshore areas. IMTA holds scope for multi-use of offshore areas and can bring environmental benefits from making use of waste products and transforming these into valuable co-products. Furthermore, they may act as alternative marine production systems and provide scope for alternative income options for coastal communities, e.g., by acting as nodes for farm operation and maintenance requirements. This paper summarizes the current state of knowledge on the implications of the exposed nature of offshore and open ocean sites on the biological, technological and socio-economic performance of IMTA. Of particular interest is improving knowledge about resource flows between integrated species in hydrodynamic challenging conditions that characterize offshore waters.

  3. Integrated health messaging for multiple neglected zoonoses: Approaches, challenges and opportunities in Morocco.

    Science.gov (United States)

    Ducrotoy, M J; Yahyaoui Azami, H; El Berbri, I; Bouslikhane, M; Fassi Fihri, O; Boué, F; Petavy, A F; Dakkak, A; Welburn, S; Bardosh, K L

    2015-12-01

    Integrating the control of multiple neglected zoonoses at the community-level holds great potential, but critical data is missing to inform the design and implementation of different interventions. In this paper we present an evaluation of an integrated health messaging intervention, using powerpoint presentations, for five bacterial (brucellosis and bovine tuberculosis) and dog-associated (rabies, cystic echinococcosis and leishmaniasis) zoonotic diseases in Sidi Kacem Province, northwest Morocco. Conducted by veterinary and epidemiology students between 2013 and 2014, this followed a process-based approach that encouraged sequential adaptation of images, key messages, and delivery strategies using auto-evaluation and end-user feedback. We describe the challenges and opportunities of this approach, reflecting on who was targeted, how education was conducted, and what tools and approaches were used. Our results showed that: (1) replacing words with local pictures and using "hands-on" activities improved receptivity; (2) information "overload" easily occurred when disease transmission pathways did not overlap; (3) access and receptivity at schools was greater than at the community-level; and (4) piggy-backing on high-priority diseases like rabies offered an important avenue to increase knowledge of other zoonoses. We conclude by discussing the merits of incorporating our validated education approach into the school curriculum in order to influence long-term behaviour change. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Binaural integration: a challenge to overcome for children with hearing loss.

    Science.gov (United States)

    Gordon, Karen A; Cushing, Sharon L; Easwar, Vijayalakshmi; Polonenko, Melissa J; Papsin, Blake C

    2017-12-01

    Access to bilateral hearing can be provided to children with hearing loss by fitting appropriate hearing devices to each affected ear. It is not clear, however, that bilateral input is properly integrated through hearing devices to promote binaural hearing. In the present review, we examine evidence indicating that abnormal binaural hearing continues to be a challenge for children with hearing loss despite early access to bilateral input. Behavioral responses and electrophysiological data in children, combined with data from developing animal models, reveal that deafness in early life disrupts binaural hearing and that present hearing devices are unable to reverse these changes and/or promote expected development. Possible limitations of hearing devices include mismatches in binaural place, level, and timing of stimulation. Such mismatches could be common in children with hearing loss. One potential solution is to modify present device fitting beyond providing audibility to each ear by implementing binaural fitting targets. Efforts to better integrate bilateral input could improve spatial hearing in children with hearing loss.

  5. Security challenges in integration of a PHR-S into a standards based national EHR.

    Science.gov (United States)

    Mense, Alexander; Hoheiser Pförtner, Franz; Sauermann, Stefan

    2014-01-01

    Health related data provided by patients themselves is expected to play a major role in future healthcare. Data from personal health devices, vaccination records, health diaries or observations of daily living, for instance, is stored in personal health records (PHR) which are maintained by personal health record systems (PHR-S). Combining this information with medical records provided by healthcare providers in electronic health records (EHR) is one of the next steps towards "personal care". Austria currently sets up a nationwide EHR system that incorporates all healthcare providers and is technically based on international standards (IHE, HL7, OASIS, ...). Looking at the expected potential of merging PHR and EHR data it is worth to analyse integration approaches. Although knowing that an integration requires the coordination of processes, information models and technical architectures, this paper specifically focuses on security issues by evaluating general security requirements for a PHR-S (based on HL7 PHR-S FM), comparing them with the information security specifications for the Austrian's national EHR (based on ISO/IES 27000 series) and identifying the main challenges as well as possible approaches.

  6. Gene expression patterns regulating embryogenesis based on the integrated de novo transcriptome assembly of the Japanese flounder.

    Science.gov (United States)

    Fu, Yuanshuai; Jia, Liang; Shi, Zhiyi; Zhang, Junling; Li, Wenjuan

    2017-06-01

    The Japanese flounder (Paralichthys olivaceus) is one of the most important commercial and biological marine fishes. However, the molecular biology involved during embryogenesis and early development of the Japanese flounder remains largely unknown due to a lack of genomic resources. A comprehensive and integrated transcriptome is necessary to study the molecular mechanisms of early development and to allow for the detailed characterization of gene expression patterns during embryogenesis; this approach is critical to understanding the processes that occur prior to mesectoderm formation during early embryonic development. In this study, more than 117.8 million 100bp PE reads were generated from pooled RNA extracted from unfertilized eggs to 41dph (days post-hatching) embryos and were sequenced using Illumina pair-end sequencing technology. In total, 121,513 transcripts (≥200bp) were obtained using de novo assembly. A sequence similarity search indicated that 52,338 transcripts show significant similarity to 22,462 known proteins from the NCBI non-redundant database and the Swiss-Prot protein database and were annotated using Blast2GO. GO terms were assigned to 44,627 transcripts with 12,006 functional terms, and 10,024 transcripts were assigned to 133 KEGG pathways. Furthermore, gene expression differences between the unfertilized egg and the gastrula embryo were analysed using Illumina RNA-Seq with single-read sequencing technology, and 24,837 differentially and specifically expressed transcripts were identified and included 5,286 annotated transcripts and 19,569 non-annotated transcripts. All of the expressed transcripts in the unfertilized egg and gastrula embryo were further classified as maternal, zygotic, or maternal-zygotic transcripts, which may help us to understand the roles of these transcripts during the embryonic development of the Japanese flounder. Thus, the results will contribute to an improved understanding of the gene expression patterns and

  7. Potentials and challenges of integration for complex metal oxides in CMOS devices and beyond

    International Nuclear Information System (INIS)

    Kim, Y; Pham, C; Chang, J P

    2015-01-01

    This review focuses on recent accomplishments on complex metal oxide based multifunctional materials and the potential they hold in advancing integrated circuits. It begins with metal oxide based high-κ materials to highlight the success of their integration since 45 nm complementary metal–oxide–semiconductor (CMOS) devices. By simultaneously offering a higher dielectric constant for improved capacitance as well as providing a thicker physical layer to prevent the quantum mechanical tunnelling of electrons, high-κ materials have enabled the continued down-scaling of CMOS based devices. The most recent technology driver has been the demand to lower device power consumption, which requires the design and synthesis of novel materials, such as complex metal oxides that exhibit remarkable tunability in their ferromagnetic, ferroelectric and multiferroic properties. These properties make them suitable for a wide variety of applications such as magnetoelectric random access memory, radio frequency band pass filters, antennae and magnetic sensors. Single-phase multiferroics, while rare, offer unique functionalities which have motivated much scientific and technological research to ascertain the origins of their multiferroicity and their applicability to potential devices. However, due to the weak magnetoelectric coupling for single-phase multiferroics, engineered multiferroic composites based on magnetostrictive ferromagnets interfacing piezoelectrics or ferroelectrics have shown enhanced multiferroic behaviour from effective strain coupling at the interface. In addition, nanostructuring of the ferroic phases has demonstrated further improvement in the coupling effect. Therefore, single-phase and engineered composite multiferroics consisting of complex metal oxides are reviewed in terms of magnetoelectric coupling effects and voltage controlled ferromagnetic properties, followed by a review on the integration challenges that need to be overcome to realize the

  8. A general design strategy for block copolymer directed self-assembly patterning of integrated circuits contact holes using an alphabet approach.

    Science.gov (United States)

    Yi, He; Bao, Xin-Yu; Tiberio, Richard; Wong, H-S Philip

    2015-02-11

    Directed self-assembly (DSA) is a promising lithography candidate for technology nodes beyond 14 nm. Researchers have shown contact hole patterning for random logic circuits using DSA with small physical templates. This paper introduces an alphabet approach that uses a minimal set of small physical templates to pattern all contacts configurations on integrated circuits. We illustrate, through experiments, a general and scalable template design strategy that links the DSA material properties to the technology node requirements.

  9. Integral measurements on Caliban and Prospero assemblies for nuclear data validation; Mesures integrales sur les assemblages Caliban et Prospero pour la validation des donnees nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Casoli, P.; Authier, N.; Richard, B. [CEA Valduc, 21 - Is-sur-Tille (France); Ducauze-Philippe, M.; Cartier, J. [CEA Bruyeres-le-Chatel, 91 (France)

    2011-07-15

    How can the quality of nuclear data libraries be checked? Performing reference experiments also called benchmarks allows the testing of evaluated data. During these experiments, integral values such as reaction rates or neutron effective multiplication coefficients are measured. In this paper, the principles of benchmark construction are explained and illustrated with several works performed on the CALIBAN et PROSPERO critical assemblies operated by the Valduc center: benchmarks for dosimetry, activation reactions studies, neutron noise measurements. (authors)

  10. Electronic alarm device for radioactivity detector associated with a direct current amplifier or with a integration-based counting assembly

    International Nuclear Information System (INIS)

    Desmaretz, Marc; Ferlicot, Rene

    1964-04-01

    The authors report the study of a device aimed at triggering sound and light alarms when a radiation detector associated with a direct current amplifier or with a counting assembly detects a radiation intensity greater than one or two previously defined thresholds. This device can be used at any time for a detection assembly which is not continuously monitored. It has been designed to be adapted to the CEA standard electronics currently used in installations and on which the alarm function had not been initially foreseen. The assembly comprises an additional safety device for the control of any untimely shutdown of the detection chain [fr

  11. Integration of leprosy services into the General Health Service in Sri Lanka: overcoming challenges to implementation in a remote district.

    Science.gov (United States)

    Wijesinghe, Thushanthi S; Wijesinghe, Pushpa Ranjan

    2013-01-01

    Sri Lanka took a policy decision to integrate leprosy services into the general health services (GHS) in 1999. This paper aims to summarize the emergence of new, specific challenges and how they were overcome during the integration of leprosy services to the GHS in a remote, leprosy endemic district in Sri Lanka. In this article, the regional epidemiologist as the team leader describes the principles used for transition to an effective integrated model of leprosy services from a centralized leprosy control model in the district. In addition, rationale for integration is viewed from the epidemiological and operational perspectives. National and district leprosy epidemiological data from secondary sources are also reviewed for corroborating the effectiveness of integration. Challenges surfaced were mainly related to the transfer of ownership of the programme, selection of appropriate service providing institutions easily accessible to clients, sustainability of leprosy services at the GHS, ensuring participation of all stakeholders in capacity building programmes and co-ordination of patient care in the absence of a dermatologist in the district. An empowered district team leader with specified roles and responsibilities, his sound technical and managerial know how and ability to translate 'team work' concept to practice were found to be essential for successful implementation of integration. Decision-making powers at the district level and flexibility to introduce new, area-specific changes to the centrally prepared core activities of integration were also vital to overcome locally surfaced challenges.

  12. The challenges of integrating multiple safeguards systems in a large nuclear facility

    International Nuclear Information System (INIS)

    Lavietes, A.; Liguori, C.; Pickrell, M.; Plenteda, R.; Sweet, M.

    2009-01-01

    Full-text: Implementing safeguards in a cost-effective manner in large nuclear facilities such as fuel conditioning, fuel reprocessing, and fuel fabrication plants requires the extensive use of instrumentation that is operated in unattended mode. The collected data is then periodically reviewed by the inspectors either on-site at a central location in the facility or remotely in the IAEA offices. A wide variety of instruments are deployed in large facilities, including video surveillance cameras, electronic sealing devices, non-destructive assay systems based on gamma ray and neutron detection, load cells for mass measurement, ID-readers, and other process-specific monitors. The challenge to integrate these different measurement instruments into an efficient, reliable, and secure system requires implementing standardization at various levels throughout the design process. This standardization includes the data generator behaviour and interface, networking solutions, and data security approaches. This standardization will provide a wide range of savings, including reduced training for inspectors and technicians, reduced periodic technical maintenance, reduced spare parts inventory, increased system robustness, and more predictive system behaviour. The development of standard building blocks will reduce the number of data generators required and allow implementation of simplified architectures that do not require local collection computers but rather utilize transmission of the acquired data directly to a central server via Ethernet connectivity. This approach will result in fewer system components and therefore reduced maintenance efforts and improved reliability. This paper discusses in detail the challenges and the subsequent solutions in the various areas that the IAEA Department of Safeguards has committed to pursue as the best sustainable way of maintaining the ability to implement reliable safeguards systems. (author)

  13. Arctic System Science: Meeting Earth System and Social Impact Challenges through Integrative Approaches and Synthesis

    Science.gov (United States)

    Vorosmarty, C. J.; Hinzman, L. D.; Rawlins, M. A.; Serreze, M. C.; Francis, J. A.; Liljedahl, A. K.; McDonald, K. C.; Piasecki, M.; Rich, R. H.; Holland, M. M.

    2017-12-01

    The Arctic is an integral part of the Earth system where multiple interactions unite its natural and human elements. Recent observations show the Arctic to be experiencing rapid and amplified signatures of global climate change. At the same time, the Arctic system's response to this broader forcing has itself become a central research topic, given its potential role as a critical throttle on future planetary dynamics. Changes are already impacting life systems and economic prosperity and continued change is expected to bear major implications far outside the region. We also have entered an era when environmental management, traditionally local in scope, must confront regional, whole biome, and pan-Arctic biogeophysical challenges. While challenges may appear to operate in isolation, they emerge within the context of an evolving, integrated Arctic system defined by interactions among natural and social sub-systems. Clearly, new efforts aimed at community planning, industrial development, and infrastructure construction must consider this multiplicity of interacting processes. We recently organized an "Arctic System Synthesis Workshop Series" supported by the Arctic Systems Science Program of NSF and devoted to exploring approaches capable of uncovering the systems-level behavior in both the natural and social sciences domains. The series featured two topical meetings. The first identified the sources responsible for extreme climate events in the Arctic. The second focused on multiple "currencies" within the system (i.e., water, energy, carbon, nutrients) and how they interact to produce systems-level behaviors. More than 40 experts participated, drawn from the ranks of Arctic natural and social sciences. We report here on the workshop series consensus report, which identifies a broad array of topics. Principal among these are a consideration of why study the Arctic as a system, as well as an articulation of the major systems-level approaches to support basic as well

  14. Towards integrated water resources management in Colombia: challenges and opportunities for spatial environmental planning

    Science.gov (United States)

    Salazar, Sergio; Hernández, Sebastián

    2015-04-01

    actions to a water culture and water use conflict management. With the premise that "access to information and research are crucial for the integrated water resources management", different planning tools have been implemented in several case studies, considering several hydro-climatic, bio-geographic and socio-cultural contexts. It was supported with a transdisciplinary approach (integrated visions from disciplines such as hydrology, biology, ecology, pedology, geomorphology, geology, economy and social sciences among others) with a key protagonist: the technical and scientific capacity available in the country. From this practical experiences at different spatial scales, we have identified a battery of key challenges: i) extend the spatial and temporal coverage of hydrometeorological and water quality monitoring networks at regional scale; ii) expand the knowledge base of aquatic and transition ecosystem as well as the environmental baseline from regional to local scales; iii) researches about the state of subterranean water resources and their interactions with lotic and lentic systems; iv) move towards the establishment of decision support systems that integrate policy objectives at different scales; v) strengthening technical and scientific capacity of the country expanding academic and research public offer; vi) unifying technical criteria and standards environment management policy; vii) institutional architecture redesign. If there is a political and socio-economical consensus about the urgency to move towards the key aspect summarized here, Colombian people will be giving the definitive step towards integrated water resources management as a cornerstone of spatial environmental planning and water governance. Disclaimer: The views and opinions expressed in this abstract are those of the authors and do not necessarily reflect the official position of the Colombian Ministry of Environment and Sustainable Development or any agency of the Colombian government.

  15. Longitudinal Omics Modelling and Integration in Clinical Metabonomics Research: challenges in childhood metabolic health research

    Directory of Open Access Journals (Sweden)

    Peter eSperisen

    2015-08-01

    Full Text Available Systems biology is an important approach for deciphering the complex processes in health maintenance and the etiology of metabolic diseases. Such integrative methodologies will help better understand the molecular mechanisms involved in growth and development throughout childhood, and consequently will result in new insights about metabolic and nutritional requirements of infants, children and adults. To achieve this, a better understanding of the physiological processes at anthropometric, cellular and molecular level for any given individual is needed. In this respect, novel omics technologies in combination with sophisticated data modelling techniques are key. Due to the highly complex network of influential factors determining individual trajectories, it becomes imperative to develop proper tools and solutions that will comprehensively model biological information related to growth and maturation of our body functions. The aim of this review and perspective is to evaluate, succinctly, promising data analysis approaches to enable data integration for clinical research, with an emphasis on the longitudinal component. Approaches based on empirical and mechanistic modelling of omics data are essential to leverage findings from high dimensional omics datasets and enable biological interpretation and clinical translation. On the one hand, empirical methods, which provide quantitative descriptions of patterns in the data, are mostly used for exploring and mining datasets. On the other hand, mechanistic models are based on an understanding of the behavior of a system’s components and condense information about the known functions, allowing robust and reliable analyses to be performed by bioinformatics pipelines and similar tools. Herein, we will illustrate current examples, challenges and perspectives in the applications of empirical and mechanistic modelling in the context of childhood metabolic health research.

  16. [Social and organizational innovation to tackle the challenge of integrated care of the chronically ill].

    Science.gov (United States)

    Nuño-Solinís, Roberto

    2014-01-01

    The increase in life expectancy, coupled with other factors, has led to an increase in the prevalence of chronic diseases and multiple morbidity. This has led to the need to develop new health and social care models, which will allow managing these efficiently and in a sustainable manner. In particular, there seems to be consensus on the need to move towards integrated, patient-centered, and more proactive care. Thus, in recent years, chronic care models have been developed at international, national and regional level, as well as introducing strategies to tackle the challenge of chronic illness. However, the implementation of actions facilitating the change towards this new model of care does not seem to be an easy task. This paper presents some of the strategic lines and initiatives carried out by the Department of Health of the Basque Government. These actions can be described within a social and organizational innovation framework, as a means for effective implementation of interventions and strategies that shape the model required for the improved care of chronic illnesses within a universal and tax-funded health system. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  17. Integration of treatment innovation planning and implementation: strategic process models and organizational challenges.

    Science.gov (United States)

    Lehman, Wayne E K; Simpson, D Dwayne; Knight, Danica K; Flynn, Patrick M

    2011-06-01

    Sustained and effective use of evidence-based practices in substance abuse treatment services faces both clinical and contextual challenges. Implementation approaches are reviewed that rely on variations of plan-do-study-act (PDSA) cycles, but most emphasize conceptual identification of core components for system change strategies. A two-phase procedural approach is therefore presented based on the integration of Texas Christian University (TCU) models and related resources for improving treatment process and program change. Phase 1 focuses on the dynamics of clinical services, including stages of client recovery (cross-linked with targeted assessments and interventions), as the foundations for identifying and planning appropriate innovations to improve efficiency and effectiveness. Phase 2 shifts to the operational and organizational dynamics involved in implementing and sustaining innovations (including the stages of training, adoption, implementation, and practice). A comprehensive system of TCU assessments and interventions for client and program-level needs and functioning are summarized as well, with descriptions and guidelines for applications in practical settings. (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  18. Conceptual and methodological challenges to integrating SEA and cumulative effects assessment

    International Nuclear Information System (INIS)

    Gunn, Jill; Noble, Bram F.

    2011-01-01

    The constraints to assessing and managing cumulative environmental effects in the context of project-based environmental assessment are well documented, and the potential benefits of a more strategic approach to cumulative effects assessment (CEA) are well argued; however, such benefits have yet to be clearly demonstrated in practice. While it is widely assumed that cumulative effects are best addressed in a strategic context, there has been little investigation as to whether CEA and strategic environmental assessment (SEA) are a 'good fit' - conceptually or methodologically. This paper identifies a number of conceptual and methodological challenges to the integration of CEA and SEA. Based on results of interviews with international experts and practitioners, this paper demonstrates that: definitions and conceptualizations of CEA are typically weak in practice; approaches to effects aggregation vary widely; a systems perspective lacks in both SEA and CEA; the multifarious nature of SEA complicates CEA; tiering arrangements between SEA and project-based assessment are limited to non-existing; and the relationship of SEA to regional planning remains unclear.

  19. What Challenges and Benefits Can Non-Formal Law and Language Integrated Learning Bring to University Students?

    Science.gov (United States)

    Atabekova, Atabekova; Gorbatenko, Rimma; Belousov, Aleksandr; Grebnev, Ruslan; Sheremetieva, Olga

    2016-01-01

    The paper explores the ways in which non-formal content and language integrated learning within university studies can affect students' academic progress. The research has included theoretical and empirical studies. The article focuses on the observation of students' learning process, draws attention to challenges and benefits students experienced…

  20. On understanding of external and internal integration in supply chains : Challenges and evaluation

    OpenAIRE

    HULTHÉN, HANA

    2016-01-01

    Benefits of implementing Supply Chain Integration (SCI) are acknowledged in existing integration literature. Integration extending beyond functional silos and firm boundaries is expected to provide value for customers in terms of higher quality, improved service level, and reduced costs. In addition, internal integration allows business functions to align around a single company goal. This type of integration promotes value creation while decreasing redundancies and costs. Yet, regardless of ...

  1. Challenges to Science and Technology Development Policy in the European Integration Policy

    Directory of Open Access Journals (Sweden)

    Valeriy Novytsky

    2004-10-01

    Full Text Available This article focuses on presentday aspects of Ukraine’s science and technology development policy in light of international phenomena and integration reali ties observed across the European continent. The author examines unique traits and practical challenges charac terizing an expansion of Ukraine — EU scientific and technological cooperation with the aim of improving the efficiency of Ukraine’s national economy and optimizing its international dimension. Special attention is paid to problems of adapting Ukraine’s technological policy to European standards, and relevant specific proposals are formulated. The article maintains that today’s advances in informa tion technology and the openness of national economies as a systemdeterminant factor of models of international cooperation broaden the scope of information technolo gies. Since telecommunications and other hitech sectors are vibrantly evolving not only in highly industrialized states but also in East European and other emerging mar ket economies, a key challenge for Ukraine appears to be lending better efficiency and productivity to its na tional policy of introducing information technologies into its socioeconomic sphere. The article provides insight into the international ex perience of the creation of technoparks and demonstrates the necessity of applying such innovation techniques of economic development to Ukraine.

  2. Current status of the post boiling transition research in Japan. Integrity evaluation of nuclear fuel assemblies after boiling transition and development of rewetting correlations

    International Nuclear Information System (INIS)

    Hara, Takashi; Mizokami, Shinya; Kudo, Yoshiro; Komura, Seiichi; Nagata, Yoshifumi; Morooka, Shinichi

    2003-01-01

    Development of rewetting correlation formula was the key to predict fuel-cladding temperature after Boiling Transition (BT). Japanese BWR utilities and vendors performed some tests of rewetting and made two rewetting correlation formulas. The effect on fuel integrity after BT depends on temperature of fuel rod and time of dryout. Main cause of losing fuel integrity during BWR's Anticipated Operational Occurrences (AOO) after BT is embrittlement of the claddings due to oxidation. Ballooning of fuel rod is excepted because its pressure boundary isn't broken. In Japan, the Standards Committee of Atomic Energy Society of Japan (AESJ) is making post BT standard. This standard provides guidelines based on the latest knowledge to judge fuel integrity in case of BT and the validity of reusing the fuel assembly that experienced BT in BWRs. (author)

  3. Bridging the Chasm: Challenges, Opportunities, and Resources for Integrating a Dissemination and Implementation Science Curriculum into Medical Education.

    Science.gov (United States)

    Ginossar, Tamar; Heckman, Carolyn J; Cragun, Deborah; Quintiliani, Lisa M; Proctor, Enola K; Chambers, David A; Skolarus, Ted; Brownson, Ross C

    2018-01-01

    Physicians are charged with implementing evidence-based medicine, yet few are trained in the science of Dissemination and Implementation (D&I). In view of the potential of evidence-based training in D&I to help close the gap between research and practice, the goal of this review is to examine the importance of D&I training in medical education, describe challenges to implementing such training, and provide strategies and resources for building D&I capacity. We conducted (1) a systematic review to identify US-based D&I training efforts and (2) a critical review of additional literature to inform our evaluation of the challenges and opportunities of integrating D&I training in medical education. Out of 269 unique articles reviewed, 11 described US-based D&I training. Although vibrant and diverse training opportunities exist, their capacity is limited, and they are not designed to meet physicians' needs. Synthesis of relevant literature using a critical review approach identified challenges inherent to changing medical education, as well as challenges related to D&I science. Finally, selected strategies and resources are available for facilitating incorporation of D&I training into medical education and overcoming existing challenges. Integrating D&I training in the medical education curriculum, and particularly in residency and fellowship training, holds promise for bridging the chasm between scientific discoveries and improved patient care and outcomes. However, unique challenges should be addressed, including the need for greater evidence.

  4. Probabilistic reasoning for assembly-based 3D modeling

    KAUST Repository

    Chaudhuri, Siddhartha; Kalogerakis, Evangelos; Guibas, Leonidas; Koltun, Vladlen

    2011-01-01

    Assembly-based modeling is a promising approach to broadening the accessibility of 3D modeling. In assembly-based modeling, new models are assembled from shape components extracted from a database. A key challenge in assembly-based modeling

  5. Microbial Challenge Testing of Single Liquid Cathode Feed Water Electrolysis Cells for the International Space Station (ISS) Oxygen Generator Assembly (OGA)

    Science.gov (United States)

    Roy, Robert J.; Wilson, Mark E.; Diderich, Greg S.; Steele, John W.

    2011-01-01

    The International Space Station (ISS) Oxygen Generator Assembly (OGA) operational performance may be adversely impacted by microbiological growth and biofilm formation over the electrolysis cell membranes. Biofilms could hinder the transport of water from the bulk fluid stream to the membranes and increase the cell concentration overpotential resulting in higher cell voltages and a shorter cell life. A microbial challenge test was performed on duplicate single liquid-cathode feed water electrolysis cells to evaluate operational performance with increasing levels of a mixture of five bacteria isolated from ISS and Space Shuttle potable water systems. Baseline performance of the single water electrolysis cells was determined for approximately one month with deionized water. Monthly performance was also determined following each inoculation of the feed tank with 100, 1000, 10,000 and 100,000 cells/ml of the mixed suspension of test bacteria. Water samples from the feed tank and recirculating water loops for each cell were periodically analyzed for enumeration and speciation of bacteria and total organic carbon. While initially a concern, this test program has demonstrated that the performance of the electrolysis cell is not adversely impacted by feed water containing the five species of bacteria tested at a concentration measured as high as 1,000,000 colony forming units (CFU)/ml. This paper presents the methodologies used in the conduct of this test program along with the performance test results at each level of bacteria concentration.

  6. Challenges in the Structure Determination of Self-Assembled Metallacages: What Do Cage Cavities Contain, Internal Vapor Bubbles or Solvent and/or Counterions?

    Science.gov (United States)

    Givelet, Cecile C; Dron, Paul I; Wen, Jin; Magnera, Thomas F; Zamadar, Matibur; Čépe, Klára; Fujiwara, Hiroki; Shi, Yue; Tuchband, Michael R; Clark, Noel; Zbořil, Radek; Michl, Josef

    2016-05-25

    Proving the structures of charged metallacages obtained by metal ion coordination-driven solution self-assembly is challenging, and the common use of routine NMR spectroscopy and mass spectrometry is unreliable. Carefully determined diffusion coefficients from diffusion-ordered proton magnetic resonance (DOSY NMR) for six cages of widely differing sizes lead us to propose a structural reassignment of two molecular cages from a previously favored trimer to a pentamer or hexamer, and another from a trimer to a much higher oligomer, possibly an intriguing tetradecamer. In the former case, strong support for the reassignment to a larger cage is provided by an observation of a slow reversible transformation of the initially formed cage into a smaller but spectrally very similar one upon dilution. In the latter case, freeze-fracture transmission electron micrographs demonstrate that at least some of the solutions are colloidal, and high-resolution electron transmission and atomic force microscopy images are compatible with a tetradecamer but not a trimer. Comparison of solute partial molar volumes deduced from measurement of solution density with volumes anticipated from molecular models argues strongly against the presence of large voids (solvent vapor bubbles) in cages dissolved in nitromethane. The presence of bubbles was previously proposed in an attempt to account for the bilinear nature of the Eyring plot of the rate constant for pyridine ligand edge exchange reaction in one of the cages and for the unusual activation parameters in the high-temperature regime. An alternative interpretation is proposed now.

  7. Magnetic self-assembly of small parts

    Science.gov (United States)

    Shetye, Sheetal B.

    Modern society's propensity for miniaturized end-user products is compelling electronic manufacturers to assemble and package different micro-scale, multi-technology components in more efficient and cost-effective manners. As the size of the components gets smaller, issues such as part sticking and alignment precision create challenges that slow the throughput of conventional robotic pick-n-place systems. As an alternative, various self-assembly approaches have been proposed to manipulate micro to millimeter scale components in a parallel fashion without human or robotic intervention. In this dissertation, magnetic self-assembly (MSA) is demonstrated as a highly efficient, completely parallel process for assembly of millimeter scale components. MSA is achieved by integrating permanent micromagnets onto component bonding surfaces using wafer-level microfabrication processes. Embedded bonded powder methods are used for fabrication of the magnets. The magnets are then magnetized using pulse magnetization methods, and the wafers are then singulated to form individual components. When the components are randomly mixed together, self-assembly occurs when the intermagnetic forces overcome the mixing forces. Analytical and finite element methods (FEM) are used to study the force interactions between the micromagnets. The multifunctional aspects of MSA are presented through demonstration of part-to-part and part-to-substrate assembly of 1 mm x 1mm x 0.5 mm silicon components. Part-to-part assembly is demonstrated by batch assembly of free-floating parts in a liquid environment with the assembly yield of different magnetic patterns varying from 88% to 90% in 20 s. Part-to-substrate assembly is demonstrated by assembling an ordered array onto a fixed substrate in a dry environment with the assembly yield varying from 86% to 99%. In both cases, diverse magnetic shapes/patterns are used to control the alignment and angular orientation of the components. A mathematical model is

  8. Integration of ICT in Curriculum: Expected Achievements and Challenges. Integration of ICT in Curriculum--The Pakistani Perspective

    Science.gov (United States)

    Tanveer, Asma

    2010-01-01

    In this age of information and technology, educational institutions not just impart knowledge to individuals, but strive to change them into lifelong learners. ICT challenges the traditional method of teaching and learning through its potential as a source of knowledge. Like other developing countries of the world, a computer revolution has taken…

  9. Integrated Testing of a Carbon Dioxide Removal Assembly and a Temperature-Swing Adsorption Compressor for Closed-Loop Air Revitalization

    Science.gov (United States)

    Knox, J. C.; Mulloth, Lila; Frederick, Kenneth; Affleck, Dave

    2003-01-01

    Accumulation and subsequent compression of carbon dioxide that is removed from space cabin are two important processes involved in a closed-loop air revitalization scheme of the International Space Station (ISS). The carbon dioxide removal assembly (CDRA) of ISS currently operates in an open loop mode without a compressor. This paper describes the integrated test results of a flight-like CDRA and a temperature-swing adsorption compressor (TSAC) for carbon dioxide removal and compression. The paper provides details of the TSAC operation at various CO2 loadings and corresponding performance of CDRA.

  10. Integral test of International Reactor Dosimetry and Fusion File with Li{sub 2}O assembly and DT neutron source at JAEA/FNS

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Satoshi, E-mail: sato.satoshi92@jaea.go.jp [Japan Atomic Energy Agency, Tokai-mura, Naka-gun, Ibaraki-ken (Japan); Kwon, Saerom; Ohta, Masayuki [Japan Atomic Energy Agency, Tokai-mura, Naka-gun, Ibaraki-ken (Japan); Ochiai, Kentaro [Japan Atomic Energy Agency, Rokkasho-mura, Kamikita-gun, Aomori-ken (Japan); Konno, Chikara [Japan Atomic Energy Agency, Tokai-mura, Naka-gun, Ibaraki-ken (Japan)

    2016-11-01

    In order to validate a new library of dosimetry cross section data, International Reactor Dosimetry and Fusion File release 1.0 (IRDFF 1.0), not only for DT neutrons but also for neutrons with energy of less than 14 MeV, we perform an integral test with a Li{sub 2}O rectangular assembly of 60.7 cm in thickness and a DT neutron source at JAEA/FNS. We place a lot of activation foils at depths of 10.1 cm and 30.4 cm for measurements of dosimetry reaction rates in small space along the central axis in the assembly, measure decay gamma-rays from the activation foils with high-purity Ge detectors after the DT neutron irradiation by the foil activation technique, and deduce a variety of dosimetry reaction rates. We calculate the reaction rates by using a Monte Carlo code MCNP5-1.40 and the nuclear data library ENDF/B-VII.1 with the IRDFF-v.1.05 as the response functions for the dosimetry reactions. The calculation results generally show good agreements with the measured ones, and it can be confirmed that most of the data in IRDFF-v.1.05 are valid for the neutron field in the Li{sub 2}O assembly with the DT neutrons.

  11. Chinese mitten crab (Eriocheir sinensis) iron-sulphur cluster assembly protein 2 (EsIscA2) is differentially regulated after immune and oxidative stress challenges.

    Science.gov (United States)

    Zhang, Peng; Liu, Yu; Wang, Min; Dong, Miren; Liu, Zhaoqun; Jia, Zhihao; Wang, Weilin; Zhang, Anguo; Wang, Lingling; Song, Linsheng

    2018-07-01

    Iron-sulphur clusters (ISCs), one of the oldest and most versatile cofactors of proteins, are involved in catalysis reactions, electron transport reactions, regulation processes as well as sensing of ambient conditions. Iron-sulphur cluster assembly protein (IscA) is a scaffold protein member of ISC formation system, which plays a significant role in the assembly and maturation process of ISC proteins. In the present study, the cDNA sequence of iron-sulphur cluster assembly protein 2 (designated as EsIscA2) was cloned from Eriocheir sinensis. The open reading frame (ORF) of EsIscA2 was of 507 bp, encoding a peptide of 168 amino acids with a typically conserved Fe-S domain. A tetrameric form was predicated by the SWISS-MODEL prediction algorithm, and three conserved cysteine residues (Cys-93, Cys-158, Cys-160) from each IscA monomer were predicted to form a 'cysteine pocket'. The deduced amino acid sequence of EsIscA2 shared over 50% similarity with that of other IscAs. EsIscA2 was clustered with IscA2 proteins from invertebrates and vertebrates, indicating that the protein was highly conservative in the evolution. rEsIscA2 exhibited a high iron binding affinity in the concentration ranging from 2 to 200 μM. EsIscA2 transcripts were detected in all the tested tissues including gonad, hemocytes, gill, muscle, heart, hepatopancreas and eyestalk, and EsIscA2 protein was detected in the mitochondria of hemocytes. The highest mRNA expression level of EsIscA2 was detected in muscle and hepatopancreas, which was about 34.66-fold (p < 0.05) and 27.07-fold (p < 0.05) of that in hemocytes, respectively. After Aeromonas hydrophila and lipopolysaccharide (LPS) stimulations, the mRNA expression of EsIscA2 in hemocytes was down-regulated and reached the lowest level at 24 h (0.31-fold, p < 0.05) and 48 h (0.29-fold, p < 0.05) compared to control group, respectively. And the expression of EsIscA2 mRNA in hepatopancreas was repressed from 6 h to 48 h post

  12. Integration of mate pair sequences to improve shotgun assemblies of flow-sorted chromosome arms of hexaploid wheat

    Czech Academy of Sciences Publication Activity Database

    Belova, T.; Zhan, B.J.; Wright, J.; Caccamo, M.; Asp, T.; Šimková, Hana; Kent, M.; Bendixen, C.; Panitz, F.; Lien, S.; Doležel, Jaroslav; Olsen, O.A.; Sandve, S.R.

    2013-01-01

    Roč. 14, APR 4 2013 (2013) ISSN 1471-2164 R&D Projects: GA ČR(CZ) GAP501/12/2554 Grant - others:GA MŠk(CZ) ED0007/01/01 Program:ED Institutional research plan: CEZ:AV0Z50380511 Keywords : Scaffold * Assembly * Wheat Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.041, year: 2013

  13. An Integrated Recovery-oriented Model (IRM) for mental health services: evolution and challenges.

    Science.gov (United States)

    Frost, Barry G; Tirupati, Srinivasan; Johnston, Suzanne; Turrell, Megan; Lewin, Terry J; Sly, Ketrina A; Conrad, Agatha M

    2017-01-17

    Over past decades, improvements in longer-term clinical and personal outcomes for individuals experiencing serious mental illness (SMI) have been moderate, although recovery has clearly been shown to be possible. Recovery experiences are inherently personal, and recovery can be complex and non-linear; however, there are a broad range of potential recovery contexts and contributors, both non-professional and professional. Ongoing refinement of recovery-oriented models for mental health (MH) services needs to be fostered. This descriptive paper outlines a service-wide Integrated Recovery-oriented Model (IRM) for MH services, designed to enhance personally valued health, wellbeing and social inclusion outcomes by increasing access to evidenced-based psychosocial interventions (EBIs) within a service context that supports recovery as both a process and an outcome. Evolution of the IRM is characterised as a series of five broad challenges, which draw together: relevant recovery perspectives; overall service delivery frameworks; psychiatric and psychosocial rehabilitation approaches and literature; our own clinical and service delivery experience; and implementation, evaluation and review strategies. The model revolves around the person's changing recovery needs, focusing on underlying processes and the service frameworks to support and reinforce hope as a primary catalyst for symptomatic and functional recovery. Within the IRM, clinical rehabilitation (CR) practices, processes and partnerships facilitate access to psychosocial EBIs to promote hope, recovery, self-agency and social inclusion. Core IRM components are detailed (remediation of functioning; collaborative restoration of skills and competencies; and active community reconnection), together with associated phases, processes, evaluation strategies, and an illustrative IRM scenario. The achievement of these goals requires ongoing collaboration with community organisations. Improved outcomes are achievable for

  14. Rocket Assembly and Checkout Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Integrates, tests, and calibrates scientific instruments flown on sounding rocket payloads. The scientific instruments are assembled on an optical bench;...

  15. An Introspection for the Field of IS Integration Challenges in M&A

    DEFF Research Database (Denmark)

    Toppenberg, Gustav; Henningsson, Stefan

    2013-01-01

    The last decade has seen a rise in research on the topic of challenges associated with information systems (IS) in corporate mergers and acquisitions (M&As). Although this proliferation of research has the potential to significantly improve our understanding of IS challenges in M&A activity, absent...

  16. Assembly tool design

    International Nuclear Information System (INIS)

    Kanamori, Naokazu; Nakahira, Masataka; Ohkawa, Yoshinao; Tada, Eisuke; Seki, Masahiro

    1996-06-01

    The reactor core of the International Thermonuclear Experimental Reactor (ITER) is assembled with a number of large and asymmetric components within a tight tolerance in order to assure the structural integrity for various loads and to provide the tritium confinement. In addition, the assembly procedure should be compatible with remote operation since the core structures will be activated by 14-MeV neutrons once it starts operation and thus personal access will be prohibited. Accordingly, the assembly procedure and tool design are quite essential and should be designed from the beginning to facilitate remote operation. According to the ITER Design Task Agreement, the Japan Atomic Energy Research Institute (JAERI) has performed design study to develop the assembly procedures and associated tool design for the ITER tokamak assembly. This report describes outlines of the assembly tools and the remaining issues obtained in this design study. (author)

  17. Challenges in transformation of the "traditional block rotation" medical student clinical education into a longitudinal integrated clerkship model.

    Science.gov (United States)

    Heddle, William; Roberton, Gayle; Mahoney, Sarah; Walters, Lucie; Strasser, Sarah; Worley, Paul

    2014-01-01

    Longitudinal integrated clerkships (LIC) in the first major clinical year in medical student training have been demonstrated to be at least equivalent to and in some areas superior to the "traditional block rotation" (TBR). Flinders University School of Medicine is starting a pilot changing the traditional teaching at the major Academic Medical Centre from TBR to LIC (50% of students in other locations in the medical school already have a partial or full LIC programme). This paper summarises the expected challenges presented at the "Rendez-Vous" Conference in October 2012: (a) creating urgency, (b) training to be a clinician rather than imparting knowledge, (c) resistance to change. We discuss the unexpected challenges that have evolved since then: (a) difficulty finalising the precise schedule, (b) underestimating time requirements, (c) managing the change process inclusively. Transformation of a "block rotation" to "LIC" medical student education in a tertiary academic teaching hospital has many challenges, many of which can be anticipated, but some are unexpected.

  18. Integrative structure modeling with the Integrative Modeling Platform.

    Science.gov (United States)

    Webb, Benjamin; Viswanath, Shruthi; Bonomi, Massimiliano; Pellarin, Riccardo; Greenberg, Charles H; Saltzberg, Daniel; Sali, Andrej

    2018-01-01

    Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use. © 2017 The Protein Society.

  19. A Needs Analysis for Technology Integration Plan: Challenges and Needs of Teachers

    Science.gov (United States)

    Vatanartiran, Sinem; Karadeniz, Sirin

    2015-01-01

    Lack of technology leadership and technology integration plans are important obstacles for using technology effectively in schools. We carried out a large-scale study to be able to design a technology integration plan for one of the pilot provinces that Fatih Project was initiated. The purpose of this research is to examine the perceived…

  20. Meeting the Challenge of Preparing Social Workers for Integrated Health Practice: Evidence from Two MSW Cohorts

    Science.gov (United States)

    Rishel, Carrie W.; Hartnett, Helen P.

    2017-01-01

    Changes in health care policy have led to an expansion of integrated care models that rely on collaboration among interprofessional health teams. Recent federal funding has encouraged the development of innovative training models to prepare social workers for integrated health practice. This article presents evidence from the first two MSW cohorts…

  1. Driven by Beliefs: Understanding Challenges Physical Science Teachers Face When Integrating Engineering and Physics

    Science.gov (United States)

    Dare, Emily A.; Ellis, Joshua A.; Roehrig, Gillian H.

    2014-01-01

    It is difficult to ignore the increased use of technological innovations in today's world, which has led to various calls for the integration of engineering into K-12 science standards. The need to understand how engineering is currently being brought to science classrooms is apparent and necessary in order to address these calls for integration.…

  2. Integrating Information Services in an Academic Setting: The Organizational and Technical Challenge.

    Science.gov (United States)

    Branin, Joseph J.; And Others

    1993-01-01

    Describes a project to integrate the support and delivery of information services to faculty and staff at the University of Minnesota from the planning phase to implementation of a new organizational entity. Topics addressed include technical and organizational integration, control and delivery of services, and networking and organizational fit.…

  3. Imagined Communities, Contested Watersheds: Challenges to Integrated Water Resources Management in Agricultural Areas

    Science.gov (United States)

    Ferreyra, Cecilia; de Loe, Rob C.; Kreutzwiser, Reid D.

    2008-01-01

    Integrated water resources management is one of the major bottom-up alternatives that emerged during the 1980s in North America as part of the trend towards more holistic and participatory styles of environmental governance. It aims to protect surface and groundwater resources by focusing on the integrated and collaborative management of land and…

  4. Challenge problem and milestones for : Nuclear Energy Advanced Modeling and Simulation (NEAMS) waste Integrated Performance and Safety Codes (IPSC).

    Energy Technology Data Exchange (ETDEWEB)

    Freeze, Geoffrey A.; Wang, Yifeng; Howard, Robert; McNeish, Jerry A.; Schultz, Peter Andrew; Arguello, Jose Guadalupe, Jr.

    2010-09-01

    This report describes the specification of a challenge problem and associated challenge milestones for the Waste Integrated Performance and Safety Codes (IPSC) supporting the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The NEAMS challenge problems are designed to demonstrate proof of concept and progress towards IPSC goals. The goal of the Waste IPSC is to develop an integrated suite of modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with robust verification, validation, and software quality requirements. To demonstrate proof of concept and progress towards these goals and requirements, a Waste IPSC challenge problem is specified that includes coupled thermal-hydrologic-chemical-mechanical (THCM) processes that describe (1) the degradation of a borosilicate glass waste form and the corresponding mobilization of radionuclides (i.e., the processes that produce the radionuclide source term), (2) the associated near-field physical and chemical environment for waste emplacement within a salt formation, and (3) radionuclide transport in the near field (i.e., through the engineered components - waste form, waste package, and backfill - and the immediately adjacent salt). The initial details of a set of challenge milestones that collectively comprise the full challenge problem are also specified.

  5. Challenge problem and milestones for: Nuclear Energy Advanced Modeling and Simulation (NEAMS) waste Integrated Performance and Safety Codes (IPSC)

    International Nuclear Information System (INIS)

    Freeze, Geoffrey A.; Wang, Yifeng; Howard, Robert; McNeish, Jerry A.; Schultz, Peter Andrew; Arguello, Jose Guadalupe Jr.

    2010-01-01

    This report describes the specification of a challenge problem and associated challenge milestones for the Waste Integrated Performance and Safety Codes (IPSC) supporting the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The NEAMS challenge problems are designed to demonstrate proof of concept and progress towards IPSC goals. The goal of the Waste IPSC is to develop an integrated suite of modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with robust verification, validation, and software quality requirements. To demonstrate proof of concept and progress towards these goals and requirements, a Waste IPSC challenge problem is specified that includes coupled thermal-hydrologic-chemical-mechanical (THCM) processes that describe (1) the degradation of a borosilicate glass waste form and the corresponding mobilization of radionuclides (i.e., the processes that produce the radionuclide source term), (2) the associated near-field physical and chemical environment for waste emplacement within a salt formation, and (3) radionuclide transport in the near field (i.e., through the engineered components - waste form, waste package, and backfill - and the immediately adjacent salt). The initial details of a set of challenge milestones that collectively comprise the full challenge problem are also specified.

  6. Fuel assembly

    International Nuclear Information System (INIS)

    Nomata, Terumitsu.

    1993-01-01

    Among fuel pellets to be loaded to fuel cans of a fuel assembly, fuel pellets having a small thermal power are charged in a region from the end of each of spacers up to about 50mm on the upstream of coolants that flow vertically at the periphery of fuel rods. Coolants at the periphery of fuel rods are heated by the heat generation, to result in voids. However, since cooling effect on the upstream of the spacers is low due to influences of the spacers. Further, since the fuel pellets disposed in the upstream region have small thermal power, a void coefficient is not increased. Even if a thermal power exceeding cooling performance should be generated, there is no worry of causing burnout in the upstream region. Even if burnout should be caused, safety margin and reliability relative to burnout are improved, to increase an allowable thermal power, thereby enabling to improve integrity and reliability of fuel rods and fuel assemblies. (N.H.)

  7. Early Child Development and Nutrition: A Review of the Benefits and Challenges of Implementing Integrated Interventions1234

    Science.gov (United States)

    Hurley, Kristen M; Yousafzai, Aisha K; Lopez-Boo, Florencia

    2016-01-01

    Poor nutrition (substandard diet quantity and/or quality resulting in under- or overnutrition) and the lack of early learning opportunities contribute to the loss of developmental potential and life-long health and economic disparities among millions of children aged child development (ECD) or nutrition have been linked to positive child development and/or nutritional status, and recommendations currently advocate for the development and testing of integrated interventions. We reviewed the theoretical and practical benefits and challenges of implementing integrated nutrition and ECD interventions along with the evidence for best practice and benefit-cost and concluded that the strong theoretical rationale for integration is more nuanced than the questions that the published empirical evidence have addressed. For example, further research is needed to 1) answer questions related to how integrated messaging influences caregiver characteristics such as well-being, knowledge, and behavior and how these influence early child nutrition and development outcomes; 2) understand population and nutritional contexts in which integrated interventions are beneficial; and 3) explore how varying implementation processes influence the efficacy, uptake, and cost-benefit of integrated nutrition and ECD interventions. PMID:26980819

  8. Fuel assembly

    International Nuclear Information System (INIS)

    Ueda, Makoto.

    1991-01-01

    In a fuel assembly in which spectral shift type moderator guide members are arranged, the moderator guide member has a flow channel resistance member, that provides flow resistance against the moderators, in the upstream of a moderator flowing channel, by which the ratio of removing coolants is set greater at the upstream than downstream. With such a constitution, the void distribution increasing upward in the channel box except for the portion of the moderator guide member is moderated by the increase of the area of the void region that expands downward in the guide member. Accordingly, the axial power distribution is flattened throughout the operation cycle and excess distortion is eliminated to improve the fuel integrity. (T.M.)

  9. Ultra-Portable Smartphone Controlled Integrated Digital Microfluidic System in a 3D-Printed Modular Assembly

    OpenAIRE

    Yafia, Mohamed; Ahmadi, Ali; Hoorfar, Mina; Najjaran, Homayoun

    2015-01-01

    Portable sensors and biomedical devices are influenced by the recent advances in microfluidics technologies, compact fabrication techniques, improved detection limits and enhanced analysis capabilities. This paper reports the development of an integrated ultraportable, low-cost, and modular digital microfluidic (DMF) system and its successful integration with a smartphone used as a high-level controller and post processing station. Low power and cost effective electronic circuits are designed...

  10. Economic testing of large integrated switching circuits - a challenge to the test engineer

    International Nuclear Information System (INIS)

    Kreinberg, W.

    1978-01-01

    With reference to large integrated switching circuits, one can use an incoming standard programme test or the customer's switching circuits. The author describes the development of suitable, extensive and economical test programmes. (orig.) [de

  11. Integration and Testing Challenges of Small Satellite Missions: Experiences from the Space Technology 5 Project

    Science.gov (United States)

    Sauerwein, Timothy A.; Gostomski, Tom

    2007-01-01

    The Space Technology 5(ST5) payload was successfully carried into orbit on an OSC Pegasus XL launch vehicle, which was carried aloft and dropped from the OSC Lockheed L-1011 from Vandenberg Air Force Base March 22,2006, at 9:03 am Eastern time, 6:03 am Pacific time. In order to reach the completion of the development and successful launch of ST 5, the systems integration and test(I&T) team determined that a different approach was required to meet the project requirements rather than the standard I&T approach used for single, room-sized satellites. The ST5 payload, part of NASA's New Millennium Program headquartered at JPL, consisted of three micro satellites (approximately 30 kg each) and the Pegasus Support Structure (PSS), the system that connected the spacecrafts to the launch vehicle and deployed the spacecrafts into orbit from the Pegasus XL launch vehicle. ST5 was a technology demonstration payload, intended to test six (6) new technologies for potential use for future space flights along with demonstrating the ability of small satellites to perform quality science. The main technology was a science grade magnetometer designed to take measurements of the earth's magnetic field. The three spacecraft were designed, integrated, and tested at NASA Goddard Space Flight Center with integration and environmental testing occurring in the Bldg. 7-1 0-15-29. The three spacecraft were integrated and tested by the same I&T team. The I&T Manager determined that there was insufficient time in the schedule to perform the three I&T spacecraft activities in series used standard approaches. The solution was for spacecraft #1 to undergo integration and test first, followed by spacecraft #2 and #3 simultaneously. This simultaneous integration was successful for several reasons. Each spacecraft had a Lead Test Conductor who planned and coordinated their spacecraft through its integration and test activities. One team of engineers and technicians executed the integration of all

  12. Integration and Testing Challenges of Small, Multiple Satellite Missions: Experiences from the Space Technology 5 Project

    Science.gov (United States)

    Sauerwein, Timothy A.; Gostomski, Thomas

    2008-01-01

    The ST5 technology demonstration mission led by GSFC of NASA's New Millennium Program managed by JPL consisted of three micro satellites (approximately 30 kg each) deployed into orbit from the Pegasus XL launch vehicle. In order to meet the launch date schedule of ST5, a different approach was required rather than the standard I&T approach used for single, room-sized satellites. The three spacecraft were designed, integrated, and tested at NASA Goddard Space Flight Center. It was determined that there was insufficient time in the schedule to perform three spacecraft I&T activities in series using standard approaches. The solution was for spacecraft #1 to undergo integration and test first, followed by spacecraft #2 and #3 simultaneously. This simultaneous integration was successful for several reasons. Each spacecraft had a Lead Test Conductor who planned and coordinated their spacecraft through its integration and test activities. One team of engineers and technicians executed the integration of all three spacecraft, learning and gaining knowledge and efficiency as spacecraft #1 integration and testing progressed. They became acutely familiar with the hardware, operation and processes for I&T, thus had the experience and knowledge to safely execute I&T for spacecraft #2 and #3. The integration team was extremely versatile; each member could perform many different activities or work any spacecraft, when needed. ST5 was successfully integrated, tested and shipped to the launch site per the I&T schedule that was planned three years previously. The I&T campaign was completed with ST5's successful launch on March 22, 2006.

  13. End-user challenges to security digitalisation and integration: a retail perspective

    OpenAIRE

    Lahtinen, Markus

    2008-01-01

    With the assumed digitalisation happening on the end-user side, progressive systems integrators stress the importance of changing the business concept from being installers to being service and solution providers. However, less is known about the details of this process on the end-user side. Based on an online survey of loss prevention managers it can be stated that security digitalisation and further business integration of security is a top agreement among the respondents. Integ...

  14. A pluralist challenge to "integrative medicine": Feyerabend and Popper on the cognitive value of alternative medicine.

    Science.gov (United States)

    Kidd, Ian James

    2013-09-01

    This paper is a critique of 'integrative medicine' as an ideal of medical progress on the grounds that it fails to realise the cognitive value of alternative medicine. After a brief account of the cognitive value of alternative medicine, I outline the form of 'integrative medicine' defended by the late Stephen Straus, former director of the US National Centre for Complementary and Alternative Medicine. Straus' account is then considered in the light of Zuzana Parusnikova's recent criticism of 'integrative medicine' and her distinction between 'cognitive' and 'opportunistic' engagement with alternative medicine. Parusnikova warns that the medical establishment is guilty of 'dogmatism' and proposes that one can usefully invoke Karl Popper's 'critical rationalism' as an antidote. Using the example of Straus, I argue that an appeal to Popper is insufficient, on the grounds that 'integrative medicine' can class as a form of cognitively-productive, critical engagement. I suggest that Parusnikova's appeal to Popper should be augmented with Paul Feyerabend's emphasis upon the role of 'radical alternatives' in maximising criticism. 'Integrative medicine' fails to maximise criticism because it 'translates' alternative medicine into the theories and terminology of allopathic medicine and so erodes its capacity to provide cognitively-valuable 'radical alternatives'. These claims are then illustrated with a discussion of 'traditional' and 'medical' acupuncture. I conclude that 'integrative medicine' fails to exploit the cognitive value of alternative medicine and so should be rejected as an ideal of medical progress. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. A challenge of regional integration: the Southern Argentinian pipeline enlargement; Desafio de integracao regional: ampliacao do gasoduto Sul-Argentino

    Energy Technology Data Exchange (ETDEWEB)

    Sardi, Oscar; Sosa, Damian [Transportadora de Gas del Sur S.A., Buenos Aires (Argentina); Duarte Filho, Arno [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2005-07-01

    The enlargement of the pipelines of Southern Argentina comprised the construction of around 500 km of 30' and 36' loops in the first semester of 2005 and presented many peculiarities. It has been the first enlargement of the argentinian pipeline system since the country's default statement, in 2001, and it has been financed and built by a bi national Brazilian-Argentinian consortium. It has also been the first time that a governmental trusteeship has been used in such an enterprise in Argentina to guarantee the necessary funds. The increasing demand of natural gas to industries and power generation plants brought about by Argentina's recent growth has stated the sense of urgency: the construction must be on duty in June 2005, ready to increase de flow of gas to the Provincia de Buenos Aires and Great Buenos Aires regions. This has represented also a technical challenge, due to the small time to built the loops, the geographical distribution of the construction, which extends from Patagonia to the Great Buenos Aires region and the meteorological conditions of the period of the construction. The article describes the negotiations done to assemble the construction's financial and managerial frameworks, the building and the solutions found to face the challenge and to meet the deadline. (author)

  16. Self-assembled monolayer of designed and synthesized triazinedithiolsilane molecule as interfacial adhesion enhancer for integrated circuit

    Directory of Open Access Journals (Sweden)

    Wang Fang

    2011-01-01

    Full Text Available Abstract Self-assembled monolayer (SAM with tunable surface chemistry and smooth surface provides an approach to adhesion improvement and suppressing deleterious chemical interactions. Here, we demonstrate the SAM comprising of designed and synthesized 6-(3-triethoxysilylpropylamino-1,3,5-triazine-2,4-dithiol molecule, which can enhance interfacial adhesion to inhibit copper diffusion used in device metallization. The formation of the triazinedithiolsilane SAM is confirmed by X-ray photoelectron spectroscopy. The adhesion strength between SAM-coated substrate and electroless deposition copper film was up to 13.8 MPa. The design strategy of triazinedithiolsilane molecule is expected to open up the possibilities for replacing traditional organosilane to be applied in microelectronic industry.

  17. Challenges of the Banking Integration Process in the Case of the New EU Member States

    Directory of Open Access Journals (Sweden)

    Dan Chirlean

    2011-04-01

    Full Text Available The creation of the single European market represents a 50 years long process which aimsat developing the most advanced economy in the world. In order to achieve this, political actions mustbe accompanied by economical and juridical changes in order to stimulate and foster the creation ofthe single European market. A key component of this process is represented by the integration of thefinancial sector. While several component of it have registered major transformations andachievements in the integration process, one of the least integrated parts is represented by theEuropean banking sector. Most of the European economies are funded directly through the bankingsector, thus the integration of this sector represents a major benchmarks in the European integrationprocess. This problem becomes more complex in the context of the European Union enlargement to27 member states. Thus, the aim of this paper is to underline the progresses achieved by the bankingsectors of the European Union new member states from Central and Eastern Europe in theirintegration process. In order to achieve this we will use an empirical analysis based on the Law of OnePrice, which will underline the progress made by the banking sectors of the panel countries: Poland,Czech Republic, Slovenia, Slovakia, Romania and Bulgaria. The results of the research will providean overview of the main achievements registered by these countries, while also underling hownational particularities of these sectors affect their integration.

  18. Meeting the Challenge of IS Curriculum Modernization: A Guide to Overhaul, Integration, and Continuous Improvement

    Science.gov (United States)

    McGann, Sean T.; Frost, Raymond D.; Matta, Vic; Huang, Wayne

    2007-01-01

    Information Systems (IS) departments are facing challenging times as enrollments decline and the field evolves, thus necessitating large-scale curriculum changes. Our experience shows that many IS departments are in such a predicament as they have not evolved content quickly enough to keep it relevant, they do a poor job coordinating curriculum…

  19. Fuels planning: science synthesis and integration; social issues fact sheet 11: Challenges to collaboration

    Science.gov (United States)

    Christine Esposito

    2006-01-01

    Bringing the right people into a collaborative process can be difficult. Potential collaborators must all feel they have something to gain to justify investing resources, sharing knowledge, and perhaps compromising on goals and actions. This fact sheet discusses some of the common challenges that individuals, communities, and institutions face in collaboration.

  20. THE CHALLENGES FOR MARKETING DISTANCE EDUCATION IN ONLINE ENVIRONMENT An Integrated Approach

    Directory of Open Access Journals (Sweden)

    Reweved by Natalija LEPKOVA

    2009-10-01

    Full Text Available Distance education, or distance learning, is a field ofeducation that focuses on the pedagogy and andragogy,technology, and instructional systems design that aim todeliver education to students who are not physically "on site".According to the U.S. Department of Agriculture, ―is a processto create and provide access to learning when the source ofinformation and the learners are separated by time anddistance, or both.‖ In other words, distance learning is theprocess of creating an educational experience of equalqualitative value for the learner to best suit their needsoutside the classroom. Rather than attending courses inperson, teachers and students may communicate at times oftheir own choosing by exchanging printed or electronic media,or through technology that allows them to communicate inreal time and through other online ways.The purpose of marketing is to understand trends in the field and customer needs in aglobal marketplace. In this case the customers are students and they could be called as a ―kings‖ of the market. This is a challenge with online learning because the field is in a constant state of development. Marketing online education programs is becoming more of a necessity as global competition increases. To be on time and in a right place-this is the target of distance learning marketing. 37 authors wrote 22 chapters from different 17 universities in 6 countries.This book is divided into six sections, each dealing with a different aspect of marketing for distance learning programs: strategic framework of marketing for open and distance learning programs; advertising, promotion, intellectual property issues and collaborativedistance education; marketing in global context; marketing of language teaching via distance and online programs; three specific case studies from Turkey; lessons learned and literature review.Strategic Framework of Marketing For Open And Distance Learning ProgramsIn the first chapter

  1. Rocky milieu: Challenges of effective integration of clinical risk management into hospitals in Iran

    Science.gov (United States)

    Farokhzadian, Jamileh; Nayeri, Nahid Dehghan; Borhani, Fariba

    2015-01-01

    Healthcare risks and clinical risks have been recognized as a major challenge in healthcare. Clinical risks can never be eliminated and can have serious adverse effects on patient safety. Thus, a clinical risk management (CRM) system has been introduced in the healthcare system to improve quality services. The aim of this study was to explore nurses’ experiences related to the challenges of implementing CRM in the organizational context. This qualitative study was based on the conventional content analysis of the Lundman and Graneheim approach, and it consisted of 22 interview sessions with 20 nurses. The purposive sampling method was used to choose the participants from three hospitals affiliated with the Kerman University of Medical Sciences. We used semi-structured interviews and review of relevant documents to collect data. The analysis of the data led to the emergence of “rocky milieu” as the main theme, and it consisted of three categories that, along with their subcategories, explain the challenges of implementing CRM. The three categories and their subcategories were (1) organizational culture and leadership challenges (decision and performance of leadership and cultural resistance to change), (2) limitation of resources (financial, human, and physical and equipment resources), and (3) variations and complexities in working conditions (the emotional, psychological, and social atmosphere and the heaviness of workload). Attempts have been made to establish CRM through clinical governance and accreditation, but organizational challenges have created a rocky milieu for implementing CRM. However, from an organizational context concerning the suitability of healthcare in Iran, there are obvious needs to move toward quality improvement and safe practices through the effective implementation of CRM. PMID:25968444

  2. [Challenges of an integrative and personalised health care for health economics and the insurance system].

    Science.gov (United States)

    Schoch, Goentje-Gesine; Würdemann, E

    2014-11-01

    "Stratifying medicine" is a topic of increasing importance in the public health system. There are several questions related to "stratifying medicine". This paper reconsiders definitions, opportunities and risks related to "stratifying medicine" as well as the main challenges of "stratifying medicine" from the perspective of a public health insurance. The application of the term and the definition are important points to discuss. Terms such as "stratified medicine", "personalised medicine" or "individualised medicine" are used. The Techniker Krankenkasse prefers "stratifying medicine", because it usually means a medicine that tailors therapy to specific groups of patients by biomarkers. OPPORTUNITIES AND RISKS: "Stratifying medicine" is associated with various hopes, e. g., the avoidance of ineffective therapies and early detection of diseases. But "stratifying medicine" also carries risks, such as an increase in the number of cases by treatment of disease risks, a duty for health and the weakening of the criteria of evidence-based medicine. The complexity of "stratifying medicine" is a big challenge for all involved parties in the health system. A lot of interrelations are still not completely understood. So the statutory health insurance faces the challenge of making innovative therapy concepts accessible in a timely manner to all insured on the one hand but on the other hand also to protect the community from harmful therapies. Information and advice to patients related to "stratifying medicine" is of particular importance. The equitable distribution of fees for diagnosis and counselling presents a particular challenge. The solidarity principle of public health insurance may be challenged by social and ethical issues of "stratifying medicine". "Stratifying medicine" offers great potential to improve medical care. However, false hopes must be avoided. Providers and payers should measure chances and risks of "stratifying medicine" together for the welfare of the

  3. Rocky milieu: Challenges of effective integration of clinical risk management into hospitals in Iran

    Directory of Open Access Journals (Sweden)

    Jamileh Farokhzadian

    2015-05-01

    Full Text Available Healthcare risks and clinical risks have been recognized as a major challenge in healthcare. Clinical risks can never be eliminated and can have serious adverse effects on patient safety. Thus, a clinical risk management (CRM system has been introduced in the healthcare system to improve quality services. The aim of this study was to explore nurses’ experiences related to the challenges of implementing CRM in the organizational context. This qualitative study was based on the conventional content analysis of the Lundman and Graneheim approach, and it consisted of 22 interview sessions with 20 nurses. The purposive sampling method was used to choose the participants from three hospitals affiliated with the Kerman University of Medical Sciences. We used semi-structured interviews and review of relevant documents to collect data. The analysis of the data led to the emergence of “rocky milieu” as the main theme, and it consisted of three categories that, along with their subcategories, explain the challenges of implementing CRM. The three categories and their subcategories were (1 organizational culture and leadership challenges (decision and performance of leadership and cultural resistance to change, (2 limitation of resources (financial, human, and physical and equipment resources, and (3 variations and complexities in working conditions (the emotional, psychological, and social atmosphere and the heaviness of workload. Attempts have been made to establish CRM through clinical governance and accreditation, but organizational challenges have created a rocky milieu for implementing CRM. However, from an organizational context concerning the suitability of healthcare in Iran, there are obvious needs to move toward quality improvement and safe practices through the effective implementation of CRM.

  4. Bringing Wellness to Schools: Opportunities for and Challenges to Mental Health Integration in School-Based Health Centers.

    Science.gov (United States)

    Lai, Karen; Guo, Sisi; Ijadi-Maghsoodi, Roya; Puffer, Maryjane; Kataoka, Sheryl H

    2016-12-01

    School-based health centers (SBHCs) reduce access barriers to mental health care and improve educational outcomes for youths. This qualitative study evaluated the innovations and challenges of a unique network of SBHCs in a large, urban school district as the centers attempted to integrate health, mental health, and educational services. The 43 participants sampled included mental health providers, primary care providers, and care coordinators at 14 SBHCs. Semistructured interviews with each participant were audio recorded and transcribed. Themes were identified and coded by using Atlas.ti 5.1 and collapsed into three domains: operations, partnership, and engagement. Interviews revealed provider models ranging from single agencies offering both primary care and mental health services to colocated services. Sites where the health agency provided at least some mental health services reported more mental health screenings. Many sites used SBHC wellness coordinators and coordination team meetings to facilitate relationships between schools and health agency and community mental health clinic providers. Partnership challenges included confidentiality policies and staff turnover. Participants also highlighted student and parent engagement through culturally sensitive services, peer health advocates, and "drop-in" lunches. Staffing and operational models are critical in the success of integrating primary care, mental health care, and education. Among the provider models observed, the combined primary care and mental health provider model offered the most integrated services. Despite barriers, providers and schools have begun to implement novel solutions to operational problems and family engagement in mental health services.

  5. Fuel Assembly Damping Summary

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kanghee; Kang, Heungseok; Oh, Dongseok; Yoon, Kyungho; Kim, Hyungkyu; Kim, Jaeyong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    This paper summary the fuel assembly damping data in air/in still water/under flow, released from foreign fuel vendors, compared our data with the published data. Some technical issues in fuel assembly damping measurement testing are also briefly discussed. Understanding of each fuel assembly damping mechanisms according to the surrounding medium and flow velocity can support the fuel design improvement in fuel assembly dynamics and structural integrity aspect. Because the upgraded requirements of the newly-developed advanced reactor system will demands to minimize fuel design margin in integrity evaluation, reduction in conservatism of fuel assembly damping can contribute to alleviate the fuel design margin for sure. Damping is an energy dissipation mechanism in a vibrating mechanical structure and prevents a resonant structure from having infinite vibration amplitudes. The sources of fuel assembly damping are various from support friction to flow contribution, and it can be increased by the viscosity or drag of surrounding fluid medium or the average velocity of water flowing. Fuel licensing requires fuel design evaluation in transient or accidental condition. Dynamic response analysis of fuel assembly is to show fuel integrity and requires information on assembly-wise damping in dry condition and under wet or water flowing condition. However, damping measurement test for the full-scale fuel assembly prototype is not easy to carry out because of the scale (fuel prototype, test facility), unsteadiness of test data (scattering, random sampling and processing), instrumentation under water flowing (water-proof response measurement), and noise. LWR fuel technology division in KAERI is preparing the infra structure for damping measurement test of full-scale fuel assembly, to support fuel industries and related research activities. Here is a preliminary summary of fuel assembly damping, published in the literature. Some technical issues in fuel assembly damping

  6. Integrating Multiple Types of Data for Signaling Research: Challenges and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Wiley, H. S.

    2011-02-15

    New technologies promise to provide unprecedented amounts of information that can provide a foundation for creating predictive models of cell signaling pathways. To be useful, however, this information must be integrated into a coherent framework. In addition, the sheer volume of data gathered from the new technologies requires computational approaches for its analysis. Unfortunately, there are many barriers to data integration and analysis, mostly because of a lack of adequate data standards and their inconsistent use by scientists. However, solving the fundamental issues of data sharing will enable the investigation of entirely new areas of cell signaling research.

  7. Architecturing hierarchical function layers on self-assembled viral templates as 3D nano-array electrodes for integrated Li-ion microbatteries.

    Science.gov (United States)

    Liu, Yihang; Zhang, Wei; Zhu, Yujie; Luo, Yanting; Xu, Yunhua; Brown, Adam; Culver, James N; Lundgren, Cynthia A; Xu, Kang; Wang, Yuan; Wang, Chunsheng

    2013-01-09

    This work enables an elegant bottom-up solution to engineer 3D microbattery arrays as integral power sources for microelectronics. Thus, multilayers of functional materials were hierarchically architectured over tobacco mosaic virus (TMV) templates that were genetically modified to self-assemble in a vertical manner on current-collectors, so that optimum power and energy densities accompanied with excellent cycle-life could be achieved on a minimum footprint. The resultant microbattery based on self-aligned LiFePO(4) nanoforests of shell-core-shell structure, with precise arrangement of various auxiliary material layers including a central nanometric metal core as direct electronic pathway to current collector, delivers excellent energy density and stable cycling stability only rivaled by the best Li-ion batteries of conventional configurations, while providing rate performance per foot-print and on-site manufacturability unavailable from the latter. This approach could open a new avenue for microelectromechanical systems (MEMS) applications, which would significantly benefit from the concept that electrochemically active components be directly engineered and fabricated as an integral part of the integrated circuit (IC).

  8. Possibilities and Challenges of ICT Integration in the Bangladesh Education System

    Science.gov (United States)

    Mou, Shahrina

    2016-01-01

    Over the past few decades, information and communications technology (ICT) has been used in changing the traditional education system. It has helped to improve the quality of education and the overall teaching-learning process. Unfortunately, many teachers still do not use ICT effectively; or, even if they use ICT, it is not integrated into their…

  9. Automation Challenges of the 80's: What to Do until Your Integrated Library System Arrives.

    Science.gov (United States)

    Allan, Ferne C.; Shields, Joyce M.

    1986-01-01

    A medium-sized aerospace library has developed interim solutions to automation needs by using software and equipment that were available in-house in preparation for an expected integrated library system. Automated processes include authors' file of items authored by employees, journal routing (including routing slips), statistics, journal…

  10. Productive Employment in Romania: A Major Challenge to the Integration into the European Union

    Directory of Open Access Journals (Sweden)

    Emilia Herman

    2016-05-01

    Full Text Available It is widely accepted that productive employment represents an essential element of inclusive economic growth, and it can be a driving force in reducing gaps between countries (especially experienced by productivity and income in order for these to integrate into the European Union. The aim of the article is to highlight the process of integration from the perspective of productive employment and its main determinants, in Romania, in the period following accession to the EU and integration into the European economic structures, the 2007-2014 period respectively. The results of this paper highlight a low level of productive employment in Romania determined mainly by low labour productivity, low wages, high vulnerable employment, high and inefficient employment in agriculture and a low level of employment in knowledge-intensive activities. The existence of large gaps, in terms of productive employment and economic development, between Romania and the developed EU countries, as well as the existence of the highest in-work poverty risk in EU emphasizes the need to accelerate productivity growth, which requires a real structural transformation, a shift from low-productivity sectors to high-productivity sectors. However, it is very important that poor workers should significantly benefit from the gains in labour productivity. The findings of this study can be useful for policy makers in order to support the improvement of productive employment so that productive employment contributes efficiently to the real integration of Romania into the EU.

  11. Istanbul : the challenges of integrated water resources management in Europa’s megacity

    NARCIS (Netherlands)

    van Leeuwen, Kees; Sjerps, Rosa

    Effective integrated water resources management (IWRM) and developments impacting on water resources are recognized as key components of environmentally sustainable development. Istanbul (Turkey) is a very large metropolitan city with a population of approximately 14 million. Istanbul is one of the

  12. International Student Carbon Footprint Challenge--Social Media as a Content and Language Integrated Learning Environment

    Science.gov (United States)

    Fauville, Géraldine; Lantz-Andersson, Annika; Säljö, Roger

    2012-01-01

    Environmental education (EE) is now clearly specified in educational standards in many parts of the world, and at the same time the view of language learning is moving towards a content and language integrated learning (CLIL) strategy, to make English lessons more relevant and attractive for students (Eurydice, 2006). In this respect,…

  13. Defining the demands and meeting the challenges of integrated bird conservation

    Science.gov (United States)

    Charles K. Baxter

    2005-01-01

    Understanding the demands of integration bird conservation begins with a critical assessment of the North American Bird Conservation Initiative's (NABCI) goal."Regionally-based, biologically-driven, landscape oriented partnerships delivering the full spectrum of bird conservation across the entirety of North America."

  14. Integrating Traditional Bullying and Cyberbullying: Challenges of Definition and Measurement in Adolescents -- A Review

    Science.gov (United States)

    Thomas, Hannah J.; Connor, Jason P.; Scott, James G.

    2015-01-01

    The need for an integrated approach to studying bullying behaviors, both traditional and cyber, in adolescents is increasingly evident. The definitional criteria of bullying are well established in the traditional bullying literature and include (i) intention, (ii) repetition, and (iii) power imbalance. There is emerging evidence that these same…

  15. Issues and Challenges Identified in the Development of a Broad Multidisciplinary Work Integrated Learning Package

    Science.gov (United States)

    Sutherland, Karen; Symmons, Mark

    2013-01-01

    Work integrated learning (WIL) units can be discipline specific and constructed for majors or degrees with a strong vocational orientation. This paper describes an undergraduate unit with its genesis in a public relations internship. The original unit enjoyed strong support from industry partners and was instrumental in many graduates securing…

  16. The Integration of Nanotechnology and Biology for Cell Engineering: Promises and Challenges

    OpenAIRE

    Krishnan, Uma Maheswari; Sethuraman, Swaminathan

    2013-01-01

    Introduction: Successful tissue engineering strategies leading to the regeneration of a tissue depend on many factors, starting from the choice of appropriate scaffold material, tailoring the surface functionalities and topography, providing the correct amount of chemical and mechanical stimuli at the appropriate time points, and ensuring the uniform and precise localization of cells. Further challenges arise when more than one cell type has to be employed for the effective regeneration of an...

  17. Integrated nutrient management, soil fertility, and sustainable agriculture: Current issues and future challenges

    OpenAIRE

    Goletti, F.; Gruhn, P.; Yudelman, M.

    2000-01-01

    Metadata only record The challenge for agriculture over the coming decades will be to meet the world's increasing demand for food in a sustainable way. Declining soil fertility and mismanagement of plant nutrients have made this task more difficult. In their 2020 Vision discussion paper, Peter Gruhn, Francesco Goletti, and Montague Yudelman point out that as long as agriculture remains a soil-based industry, major increases in productivity are unlikely to be attained without ensuring that ...

  18. An Integrative, Multilevel, and Transdisciplinary Research Approach to Challenges of Work, Family, and Health

    Science.gov (United States)

    Bray, Jeremy W.; Kelly, Erin L.; Hammer, Leslie B.; Almeida, David M.; Dearing, James W.; King, Rosalind B.; Buxton, Orfeu M.

    2013-01-01

    Recognizing a need for rigorous, experimental research to support the efforts of workplaces and policymakers in improving the health and wellbeing of employees and their families, the National Institutes of Health and the Centers for Disease Control and Prevention formed the Work, Family & Health Network (WFHN). The WFHN is implementing an innovative multisite study with a rigorous experimental design (adaptive randomization, control groups), comprehensive multilevel measures, a novel and theoretically based intervention targeting the psychosocial work environment, and translational activities. This paper describes challenges and benefits of designing a multilevel and transdisciplinary research network that includes an effectiveness study to assess intervention effects on employees, families, and managers; a daily diary study to examine effects on family functioning and daily stress; a process study to understand intervention implementation; and translational research to understand and inform diffusion of innovation. Challenges were both conceptual and logistical, spanning all aspects of study design and implementation. In dealing with these challenges, however, the WFHN developed innovative, transdisciplinary, multi-method approaches to conducting workplace research that will benefit both the research and business communities. PMID:24618878

  19. Assembling large, complex environmental metagenomes

    Energy Technology Data Exchange (ETDEWEB)

    Howe, A. C. [Michigan State Univ., East Lansing, MI (United States). Microbiology and Molecular Genetics, Plant Soil and Microbial Sciences; Jansson, J. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Sciences Division; Malfatti, S. A. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Tringe, S. G. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Tiedje, J. M. [Michigan State Univ., East Lansing, MI (United States). Microbiology and Molecular Genetics, Plant Soil and Microbial Sciences; Brown, C. T. [Michigan State Univ., East Lansing, MI (United States). Microbiology and Molecular Genetics, Computer Science and Engineering

    2012-12-28

    The large volumes of sequencing data required to sample complex environments deeply pose new challenges to sequence analysis approaches. De novo metagenomic assembly effectively reduces the total amount of data to be analyzed but requires significant computational resources. We apply two pre-assembly filtering approaches, digital normalization and partitioning, to make large metagenome assemblies more computationaly tractable. Using a human gut mock community dataset, we demonstrate that these methods result in assemblies nearly identical to assemblies from unprocessed data. We then assemble two large soil metagenomes from matched Iowa corn and native prairie soils. The predicted functional content and phylogenetic origin of the assembled contigs indicate significant taxonomic differences despite similar function. The assembly strategies presented are generic and can be extended to any metagenome; full source code is freely available under a BSD license.

  20. The Challenges of Integrating NASA's Human, Budget, and Data Capital within the Constellation Program's Exploration Launch Projects Office

    Science.gov (United States)

    Kidd, Luanne; Morris, Kenneth B.; Self, Tim

    2006-01-01

    The U.S. Vision for Space Exploration directs NASA to retire the Space Shuttle in 2010 and replace it with safe, reliable, and cost-effective space transportation systems for crew and cargo travel to the Moon, Mars, and beyond. Such emerging space transportation initiatives face massive organizational challenges, including building and nurturing an experienced, dedicated team with the right skills for the required tasks; allocating and tracking the fiscal capital invested in achieving technical progress against an integrated master schedule; and turning generated data into usehl knowledge that equips the team to design and develop superior products for customers and stakeholders. This paper discusses how NASA's Exploration Launch Projects Office, which is responsible for delivering these new launch vehicles, integrates these resources to create an engineering business environment that promotes mission success.

  1. TPX assembly plan

    International Nuclear Information System (INIS)

    Knutson, D.

    1993-01-01

    The TPX machine will be assembled in the TFTR Test Cell at the Plasma Physics Laboratory, utilizing the existing TFTR machine foundation. Preparation of the area for assembly will begin after completion of the decontamination and decommissioning phase on TFTR and certification that the radiation levels remaining, if any, are consistent with the types of operations planned. Assembly operations begin with the arrival of the first components, and conclude, approximately 24 months later, with the successful completion of the integrated systems tests and the achievement of a first plasma

  2. Investigating the role of viral integral membrane proteins in promoting the assembly of nepovirus and comovirus replication factories

    Directory of Open Access Journals (Sweden)

    Helene eSanfacon

    2013-01-01

    Full Text Available Formation of plant virus membrane-associated replication factories requires the association of viral replication proteins and viral RNA with intracellular membranes, the recruitment of host factors and the modification of membranes to form novel structures that house the replication complex. Many viruses encode integral membrane proteins that act as anchors for the replication complex. These hydrophobic proteins contain trans-membrane domains and/or amphipathic helices that associate with the membrane and modify its structure. The comovirus Co-Pro and NTP-binding (NTB, putative helicase proteins and the cognate nepovirus X2 and NTB proteins are among the best characterized plant virus integral membrane replication proteins and are functionally related to the picornavirus 2B, 2C and 3A membrane proteins. The identification of membrane-association domains and analysis of the membrane topology of these proteins is discussed. The evidence suggesting that these proteins have the ability to induce membrane proliferation, alter the structure and integrity of intracellular membranes and modulate the induction of symptoms in infected plants is also reviewed. Finally, areas of research that need further investigation are highlighted.

  3. Toho Gas accepts the challenge of operational reform creation of an integrated OA environment

    International Nuclear Information System (INIS)

    Kato, Hisaatsu; Ito, Mari; Goto, Akihito

    1997-01-01

    Toho Gas Co., Ltd. is Japan's third largest city gas supplier. In response to changes in the industrial environment, the company began the Integrated OA Project in 1994 promoting use of information technology while reforming its systems and culture. We made a proposal to distribute one personal computer connected to a company-wide network to each office worker. In addition, we attached importance to the creation of a database, which can integrate all information systems with a flexible structure and also play a central role in end user computing. A data model for the entire company has been already made and implemented into some operational systems and data-warehouses. Furthermore, to reform our business we are offering incremental goals, including the first step such as achieving a paper less working environment with a little effort. This methodology has achieved a great success. In the near future, we will expand the infrastructure with mobile computers and implementation of a database. (au)

  4. Integrating knowledge across domains to advance the science of health behavior: overcoming challenges and facilitating success.

    Science.gov (United States)

    Klein, William M P; Grenen, Emily G; O'Connell, Mary; Blanch-Hartigan, Danielle; Chou, Wen-Ying Sylvia; Hall, Kara L; Taber, Jennifer M; Vogel, Amanda L

    2017-03-01

    Health behaviors often co-occur and have common determinants at multiple levels (e.g., individual, relational, environmental). Nevertheless, research programs often examine single health behaviors without a systematic attempt to integrate knowledge across behaviors. This paper highlights the significant potential of cross-cutting behavioral research to advance our understanding of the mechanisms and causal factors that shape health behaviors. It also offers suggestions for how researchers could develop more effective interventions. We highlight barriers to such an integrative science along with potential steps that can be taken to address these barriers. With a more nuanced understanding of health behavior, redundancies in research can be minimized, and a stronger evidence base for the development of health behavior interventions can be realized.

  5. The application of "integrated marketing communications" to social marketing and health communication: organizational challenges and implications.

    Science.gov (United States)

    Nowak, G; Cole, G; Kirby, S; Freimuth, V; Caywood, C

    1998-01-01

    Influencing consumer behavior is a difficult and often resource-intensive undertaking, with success usually requiring identifying, describing, and understanding target audiences; solid product and/or service positioning relative to competitors; and significant media and communication resources. Integrated marketing communication (IMC) is a new way of organizing and managing persuasive communication tools and functions which involves realigning communications to consider the flow of information from an organization from the viewpoint of end consumers. Although the application of IMC to social marketing remains relatively unexplored, the IMC literature and recent efforts by the US Centers for Disease Prevention and Control suggest that integrated communication approaches have much to offer social marketing and health communication efforts. IMC, IMC and social marketing, and implications of IMC for public and private sector social marketing programs are discussed.

  6. Integration of Plant Metabolomics Data with Metabolic Networks: Progresses and Challenges.

    Science.gov (United States)

    Töpfer, Nadine; Seaver, Samuel M D; Aharoni, Asaph

    2018-01-01

    In the last decade, plant genome-scale modeling has developed rapidly and modeling efforts have advanced from representing metabolic behavior of plant heterotrophic cell suspensions to studying the complex interplay of cell types, tissues, and organs. A crucial driving force for such developments is the availability and integration of "omics" data (e.g., transcriptomics, proteomics, and metabolomics) which enable the reconstruction, extraction, and application of context-specific metabolic networks. In this chapter, we demonstrate a workflow to integrate gas chromatography coupled to mass spectrometry (GC-MS)-based metabolomics data of tomato fruit pericarp (flesh) tissue, at five developmental stages, with a genome-scale reconstruction of tomato metabolism. This method allows for the extraction of context-specific networks reflecting changing activities of metabolic pathways throughout fruit development and maturation.

  7. Integrated ecological-economic fisheries models - evaluation, review and challenges for implementation

    DEFF Research Database (Denmark)

    Nielsen, J. Rasmus; Thunberg, Eric; Holland, Daniel S.

    2018-01-01

    and comparative evaluation of 35 IESFM´s applied to marine fisheries and marine ecosystem resources to identify the characteristics that determine their usefulness, effectiveness and implementation. The focus is on fully integrated models that allow for feedbacks between ecological and human processes though......Marine ecosystems evolve under many interconnected and area-specific pressures. In order to fulfill society's intensifying and diversifying needs whilst ensuring ecologically sustainable development, more effective marine spatial planning and broader-scope management of marine resources...... is necessary. Integrated ecological–socioeconomic fisheries models (IESFM) of marine systems are nee¬ded to evaluate impacts and sustainability of potential management actions and understand, and anti¬ci¬pate ecological, economic, and social dynamics at a range of scales from local to national and regional...

  8. Experiences in applying Bayesian integrative models in interdisciplinary modeling: the computational and human challenges

    DEFF Research Database (Denmark)

    Kuikka, Sakari; Haapasaari, Päivi Elisabet; Helle, Inari

    2011-01-01

    We review the experience obtained in using integrative Bayesian models in interdisciplinary analysis focusing on sustainable use of marine resources and environmental management tasks. We have applied Bayesian models to both fisheries and environmental risk analysis problems. Bayesian belief...... be time consuming and research projects can be difficult to manage due to unpredictable technical problems related to parameter estimation. Biology, sociology and environmental economics have their own scientific traditions. Bayesian models are becoming traditional tools in fisheries biology, where...

  9. On challenges and opportunities of designing integrated IT platforms for supporting knowledge works in organizations

    OpenAIRE

    Laha, Arijit

    2009-01-01

    Designing and implementing comprehensive IT-based support environments for KM in organizations is fraught with many problems. Solving them requires intimate knowledge about the information usage in knowledge works and the scopes of technology intervention. In this paper, the Task-oriented Organizational Knowledge Management or TOKM, a design theory for building integrated IT platforms for supporting organizational KM, is proposed. TOKM brings together two apparently mutually exclusive practic...

  10. Integrated Payment and Delivery Models Offer Opportunities and Challenges for Residential Care Facilities

    OpenAIRE

    Grabowski, David C.; Caudry, Daryl J.; Dean, Katie M.; Stevenson, David G.

    2015-01-01

    Under health care reform, a series of new financing and delivery models are being piloted to integrate health and long-term care services for older adults. To date, these programs have not encompassed residential care facilities, with most programs focusing on long-term care recipients in the community or the nursing home. Our analyses indicate that individuals living in residential care facilities have similarly high rates of chronic illness and Medicare utilization when compared with simila...

  11. CO2 supply from an integrated network : the opportunities and challenges

    International Nuclear Information System (INIS)

    Heath, M.

    2006-01-01

    Strategies for using carbon dioxide (CO 2 ) from an integrated network were discussed. The oil and gas industry is currently considering carbon capture and storage (CCS) scenarios for Alberta. Integrated scenarios are aimed at providing business solution for CO 2 currently being produced in the province as well as optimizing the amounts of CO 2 that can be stored in geologic sinks. The scenarios hope to transform CCS into a value-added market capable of providing optimal returns to stakeholders along the CO 2 supply chain through the creation of an infrastructure designed to transport CO 2 in sufficient volumes. The storage of CO 2 in geologic sinks is expected to remove optimal amounts of anthropogenic CO 2 from larger stationary point sources. Interest in an integrated CO 2 market in Alberta has arisen from both economic and environmental concerns. The most effective CO 2 sources are fertilizer, gas processing, and hydrogen plants. Petrochemical facilities also produce high purity CO 2 . CO 2 capture approaches include post- and pre-combustion capture technologies as well as oxyfuel conversion. It was concluded that the cost of capturing CO 2 depends on concentration and purity levels obtained at the point of capture. Major CO 2 sources in the Western Canadian Sedimentary Basin (WCSB) were provided. tabs., figs

  12. Towards adaptive and integrated management paradigms to meet the challenges of water governance.

    Science.gov (United States)

    Halbe, J; Pahl-Wostl, C; Sendzimir, J; Adamowski, J

    2013-01-01

    Integrated Water Resource Management (IWRM) aims at finding practical and sustainable solutions to water resource issues. Research and practice have shown that innovative methods and tools are not sufficient to implement IWRM - the concept needs to also be integrated in prevailing management paradigms and institutions. Water governance science addresses this human dimension by focusing on the analysis of regulatory processes that influence the behavior of actors in water management systems. This paper proposes a new methodology for the integrated analysis of water resources management and governance systems in order to elicit and analyze case-specific management paradigms. It builds on the Management and Transition Framework (MTF) that allows for the examination of structures and processes underlying water management and governance. The new methodology presented in this paper combines participatory modeling and analysis of the governance system by using the MTF to investigate case-specific management paradigms. The linking of participatory modeling and research on complex management and governance systems allows for the transfer of knowledge between scientific, policy, engineering and local communities. In this way, the proposed methodology facilitates assessment and implementation of transformation processes towards IWRM that require also the adoption of adaptive management principles. A case study on flood management in the Tisza River Basin in Hungary is provided to illustrate the application of the proposed methodology.

  13. Bacteriophage Assembly

    Directory of Open Access Journals (Sweden)

    Anastasia A. Aksyuk

    2011-02-01

    Full Text Available Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of assembly precursors. The sequence and molecular mechanisms of phage assembly have been elucidated by a variety of methods. Differences and similarities of assembly processes in several different groups of bacteriophages are discussed in this review. The general principles of phage assembly are applicable to many macromolecular complexes.

  14. Fuel assemblies

    International Nuclear Information System (INIS)

    Nakatsuka, Masafumi.

    1979-01-01

    Purpose: To prevent scattering of gaseous fission products released from fuel assemblies stored in an fbr type reactor. Constitution; A cap provided with means capable of storing gas is adapted to amount to the assembly handling head, for example, by way of threading in a storage rack of spent fuel assemblies consisting of a bottom plate, a top plate and an assembly support mechanism. By previously eliminating the gas inside of the assembly and the cap in the storage rack, gaseous fission products upon loading, if released from fuel rods during storage, are stored in the cap and do not scatter in the storage rack. (Horiuchi, T.)

  15. Sequence assembly

    DEFF Research Database (Denmark)

    Scheibye-Alsing, Karsten; Hoffmann, S.; Frankel, Annett Maria

    2009-01-01

    Despite the rapidly increasing number of sequenced and re-sequenced genomes, many issues regarding the computational assembly of large-scale sequencing data have remain unresolved. Computational assembly is crucial in large genome projects as well for the evolving high-throughput technologies and...... in genomic DNA, highly expressed genes and alternative transcripts in EST sequences. We summarize existing comparisons of different assemblers and provide a detailed descriptions and directions for download of assembly programs at: http://genome.ku.dk/resources/assembly/methods.html....

  16. The challenges of teaching geographical information systems integrated into the management of environment and natural resources

    International Nuclear Information System (INIS)

    Escobar, John; Betancur, Teresita; Palacio, Carlos

    2008-01-01

    The Geographic Information Systems, GIS, have the potential to become tools and methodologies for the solution of practical problems that involve complex spatial analyses, like the associated with natural resources and environmental management areas. The university, with its postgraduate programs, can help with the social adaptation processes for this new technology and can contribute to achieve the success sooner and with more effectiveness. To do so, three main challenges must be reached in the users of this technology: first, a spatial thinking second, skills to design and to make use of this instrument as supporting in environmental and natural resources analyses and finally, the identification of strategies to use this technology in projects and corporative surroundings. The Antioquia University in its Engineering Faculty (at first, in agreement with the Education Faculty)developed a Specialization in Environment and Geoinformatic. In this, the curriculum is worked in three moments (one for each challenge): first, a moment to building a common language and to adopting conceptual and technical instruments? second, a moment to put together instruments and methods and finally, a moment to make the practical application of the environmental management supported in the geo information spatial systems. This article gives account of this institutional experience.

  17. Integrating nurse researchers in clinical practice – a challenging, but necessary task for nurse leaders

    DEFF Research Database (Denmark)

    Hølge-Hazelton, Bibi; Kjerholt, Mette; Berthelsen, Connie Bøttcher

    2016-01-01

    nursing, including integrating nurse researchers in ANP positions. Methods A collective case study including three ANPs took place at a large regional hospital in Denmark. The cases were first analysed by focusing on the generic features, functions and skills of ANPs, and second by focusing...... on the approaches to evidence-based practice seen in the cases. Results Regardless of same position, formal level of research expertise and overall responsibility, different approaches related to each ANPs professional profile, interest, academic ambitions and personality were seen. Conclusion Nurse leaders must...

  18. SHARP's systems engineering challenge: rectifying integrated product team requirements with performance issues in an evolutionary spiral development acquisition

    Science.gov (United States)

    Kuehl, C. Stephen

    2003-08-01

    Completing its final development and early deployment on the Navy's multi-role aircraft, the F/A-18 E/F Super Hornet, the SHAred Reconnaissance Pod (SHARP) provides the war fighter with the latest digital tactical reconnaissance (TAC Recce) Electro-Optical/Infrared (EO/IR) sensor system. The SHARP program is an evolutionary acquisition that used a spiral development process across a prototype development phase tightly coupled into overlapping Engineering and Manufacturing Development (EMD) and Low Rate Initial Production (LRIP) phases. Under a tight budget environment with a highly compressed schedule, SHARP challenged traditional acquisition strategies and systems engineering (SE) processes. Adopting tailored state-of-the-art systems engineering process models allowd the SHARP program to overcome the technical knowledge transition challenges imposed by a compressed program schedule. The program's original goal was the deployment of digital TAC Recce mission capabilities to the fleet customer by summer of 2003. Hardware and software integration technical challenges resulted from requirements definition and analysis activities performed across a government-industry led Integrated Product Team (IPT) involving Navy engineering and test sites, Boeing, and RTSC-EPS (with its subcontracted hardware and government furnished equipment vendors). Requirements development from a bottoms-up approach was adopted using an electronic requirements capture environment to clarify and establish the SHARP EMD product baseline specifications as relevant technical data became available. Applying Earned-Value Management (EVM) against an Integrated Master Schedule (IMS) resulted in efficiently managing SE task assignments and product deliveries in a dynamically evolving customer requirements environment. Application of Six Sigma improvement methodologies resulted in the uncovering of root causes of errors in wiring interconnectivity drawings, pod manufacturing processes, and avionics

  19. Integrated effect of supramolecular self-assembled sandwich-like melamine cyanurate/MoS{sub 2} hybrid sheets on reducing fire hazards of polyamide 6 composites

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Xiaming [State Key Laboratory of Fire Science, University of Science and Technology of China, Anhui 230026 (China); Suzhou Key Laboratory of Urban Public Safety, Suzhou Institute for Advanced Study, University of Science and Technology of China, Suzhou, Jiangsu 215123 (China); Wang, Xin, E-mail: wxcmx@ustc.edu.cn [State Key Laboratory of Fire Science, University of Science and Technology of China, Anhui 230026 (China); Cai, Wei; Hong, Ningning [State Key Laboratory of Fire Science, University of Science and Technology of China, Anhui 230026 (China); Hu, Yuan, E-mail: yuanhu@ustc.edu.cn [State Key Laboratory of Fire Science, University of Science and Technology of China, Anhui 230026 (China); Suzhou Key Laboratory of Urban Public Safety, Suzhou Institute for Advanced Study, University of Science and Technology of China, Suzhou, Jiangsu 215123 (China); Liew, Kim Meow [Suzhou Key Laboratory of Urban Public Safety, Suzhou Institute for Advanced Study, University of Science and Technology of China, Suzhou, Jiangsu 215123 (China); Department of Architectural and Civil Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon (Hong Kong)

    2016-12-15

    A novel strategy of using supramolecular self-assembly for preparing sandwich-like melamine cyanurate/MoS{sub 2} sheets as the hybrid flame retardants for polyamide 6 (PA6) is reported for the first time. The introduction of MoS{sub 2} sheets function not only as a template to induce the formation of two-dimensional melamine cyanurate capping layers but also as a synergist to generate integrated flame-retarding effect of hybrid sheets, as well as a high-performance smoke suppressor to reduce fire hazards of PA6 materials. Once incorporating this well-designed structures (4 wt%) into PA6 matrix, there resulted in a remarkable drop (40%) in the peak heat release rate and a 25% reduction in total heat release. Moreover, the smoke production and pyrolysis gaseous products were efficiently suppressed by the addition of sandwich-like hybrid sheets. The integrated functions consisting of inherent flame retarding effect, physical barrier performance and catalytic activity are believed to the crucial guarantee for the reduced fire hazards of PA6 nanocomposites. Furthermore, this novel strategy with facile and scalable features may provide reference for developing various kinds of MoS{sub 2} based hybrid sheets for diverse applications.

  20. Integrating psychology with interpersonal communication skills in undergraduate nursing education: addressing the challenges.

    Science.gov (United States)

    McCarthy, Bridie; Trace, Anna; O'Donovan, Moira

    2014-05-01

    The inclusion of the social, behavioural and bio-sciences is acknowledged as essential to the development of the art and science of nursing. Nonetheless, the literature highlights on-going debate about the content and delivery of these subject areas in undergraduate nursing education. The bio-sciences and social sciences in particular have received much attention but more recently the inclusion of psychology in nursing curricula is gaining momentum. Studies conducted on nursing students' views of these supporting sciences have also highlighted problems with their understanding, relevance and application to nursing practice. Although broad guidelines are given as to what should be included, no detail is given as to how much detail or at what level these subjects should be taught. Subsequently, approved institutions are responsible for their own course content. This has resulted in inconsistent and varied approaches to integrating the sciences in undergraduate nursing curricula. Following a recent review of the undergraduate nursing curriculum in one university in the Republic of Ireland a decision was made to combine the teaching, learning and assessment of Applied Psychology with Interpersonal Communication skills. This paper will describe the developmental process and evaluation of the integrated module. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. China’s Foreign Direct Investments:Challenges of Due Diligence and Organizational Integration

    Institute of Scientific and Technical Information of China (English)

    ABDOL; S.SOOFI

    2015-01-01

    This paper critically reviews Chinese companies’ foreign direct investment practices of recent years. Using case studies involving overseas Greenfield as well as merger and acquisition(M&A;) of Chinese enterprises, we aim to draw lessons from these experiences. However, because of increasing importance of outbound acquisitions by Chinese companies, this paper focuses on Chinese M&A; activities. After presenting the theoretical discussions of post-acquisition organizational integration, this paper identifies factors that have contributed to less than expected performances of Chinese foreign investments. Three main factors are identified as the plausible causes of the less than satisfactory outcomes: inadequate due diligence, not considering political and country risks, and cultural differences. In all cases, inexperience of Chinese enterprises in foreign direct investment, either in Greenfield form or M&A;, has attributed to the problems. Therefore, summing the experiences of the Chinese enterprises that have foreign direct investment is essential for those Chinese investors that intend to invest overseas. Conduct of meaningful, in-depth due diligence before serious negotiations for investment or acquisition, inclusion of risk premium for political risk in cash flow analysis, and early post-merger integration planning are essential for avoidances of bitter outcomes many Chinese investors experienced overseas.

  2. Towards strategic stakeholder management? Integrating perspectives on sustainability challenges such as corporate responses to climate change

    International Nuclear Information System (INIS)

    Kolk, A.; Pinkse, J.

    2007-01-01

    The strategic management of corporate sustainability tends to be approached from one theoretical perspective in academic research and publications in mainstream journals simultaneously. In corporate practice, however, a sustainability issue has different dimensions that cannot be captured if only one such lens is taken. The purpose of this article is to develop a more integrated perspective, embedded in a stakeholder view. This paper uses climate change as an example to illustrate how institutional, resource-based, supply chain and stakeholder views are all important to characterize and understand corporate strategic responses to one issue. This is subsequently linked to the climate strategies and related capabilities of companies, reckoning with societal and competitive contexts. Findings - What a corporate climate strategy looks like depends on the type of stakeholders that a company manages more proactively, which is in turn determined by the extent to which these stakeholders control critical resources. While empirical literature usually adopts a particular theoretical perspective, this article has attempted to develop a more integrative approach on corporate responses to climate change

  3. SMQIE: Challenges associated with a low frequency charge integrator and encoder for the CDF II Calorimeter

    International Nuclear Information System (INIS)

    J. Hoff, G. Drake, A. Byon-Wagner, G. Foster and M. Lindgren

    1999-01-01

    The SMQIE is the newest member of the QIE family of integrated circuits. It has been developed specifically for the Shower Max Detector upgrade of the CDF Plug and Central Calorimeters at Fermilab. Like its predecessors, it converts charges over a wide dynamic range with a variable resolution. Unlike its predecessors it contains its own Flash, trigger delay pipeline and buffer area. Furthermore, it operates both at a lower frequency and with only a simple 5-volt power supply. The simultaneous requirements of low frequency and reduced voltage force the front end into a low current, high impedance regime. Specialized circuitry is necessary to prevent charge slopped-over into subsequent time slices. The considerable amount of digital circuitry monolithic with the analog front end makes for a noisy substrate. Specialized circuitry and layout techniques are necessary to keep this chip from being noise-limited. The final design is a two-channel single-ended Charge Integrator and Encoder (QIE) that operates at a frequency of 7.6MHz with a least significant bit resolution of 15 fC in its lowest range

  4. Integrated challenge test: a new approach evaluating quantitative risk assessment of Listeria in ready to eat foods

    Directory of Open Access Journals (Sweden)

    Paolo Matteini

    2012-02-01

    Full Text Available The study was aimed to predict the maximum concentration of Listeria monocytogenes during the shelf life in chicken liver paté. The prediction has been performed using the integrated challenge test: a test based on the interaction between indigenous lactic flora and L. monocytogenes and their growth parameters. Two different approaches were investigated: the former is based on the time difference between the onset of the L. monocytogenes and the lactic flora stationary phases, while the latter is based on the lactic flora concentration capable to induct the stationary phase of L. monocytogenes. Three different strains of L. monocytogenes, isolated from meat products, were used to perform three challenge tests. Triplicate samples from three different batches of liver paté were inoculated with a single-strain inoculum of 1.8 Log CFU/g. Samples were then stored at 4°C, 8°C and 12°C. Lactobacillus spp. (ISO 15214:1998 and L. monocytogenes (UNI EN ISO 11290-02:2005 plate counts were performed daily on each sample until the stationary phase was reached by both populations. The challenge test results were input in the Combase software to determine the growth parameters, later used for the calculation method. Predictive data were then statically assessed against the results of two additional challenge tests using triplicate samples from two different batches, the same strains and the same single-strain inoculum. Samples from the first batch were stored for 5 days at 4°C + 5 days at 8°C + 5 days at 12°C; samples from the second batch were stored for 3 days at 4°C + 3 days at 8°C + 4 days at 12°C. The results obtained showed that both approaches provided results very close to the reality. Therefore the Integrated challenge test is useful to determine the maximum concentration of L. monocytogenes, by simply knowing the concentration of the concerned microbial populations at a given time.

  5. Family members facilitating community re-integration and return to productivity following traumatic brain injury - motivations, roles and challenges.

    Science.gov (United States)

    Gagnon, Alicia; Lin, Jenny; Stergiou-Kita, Mary

    2016-01-01

    This study explores the experiences of family members in supporting community re-integration and return to productive occupations of the traumatic brain injury (TBI) survivor in order to: (i) describe family members' supportive roles, (ii) determine challenges family members experience in supporting the TBI survivor; and (iii) identify supports that family members require to maintain and enhance their roles. This qualitative descriptive study involved 14 interviews with immediate family members of TBI survivors. Data was analyzed using thematic analysis. Family members expressed strong motivation and engaged in six key roles to support TBI survivors: researcher, case manager, advocate, coach, activities of daily living (ADL)/instrumental ADLs and emotional supporter. Personal and family stressors and challenges navigating the health care system were perceived as challenges in meeting demands of their supportive roles. Stigma also presented a barrier to successful community and vocational re-integration. Subsequently, family members desired more education related to the functional implications of TBI, to be connected to health care and community resources, and sought a greater family-centred care approach. Family members require on-going counseling and community supports to prevent burnout and allow for their continued engagement in their supportive roles. Further education on how to navigate the health care system, access community programs and rights to workplace accommodation is also warranted. Family members are strongly motivated to support survivors' return to productive occupation following a traumatic brain injury, but require counseling and community support to enable their on-going engagement and prevent burnout. Family members can be further empowered through the implementation of family-centred care. Family members requested further education on the long-term functional implications of TBI, how to navigate the health care system, how to access community

  6. Towards an integral analysis of stereotypes: Challenging the standard guarantee of impartiality

    Directory of Open Access Journals (Sweden)

    Laura Clérico

    2018-05-01

    Full Text Available The use of stereotypes to the detriment of the discriminated group should imply questioning the standard guarantee of judicial impartiality. Even taking the analysis of stereotypes seriously, the depth of its consequences has not been sufficiently taken into account in the constitutional and human rights argumentation because it has not challenged with all intensity the standard way in which the guarantee of impartiality is conceived and applied in legal practice and even by the regional court for the protection of human rights. I will defend two central theses: (1 the use of stereotypes necessarily impacts on the analysis of the guarantee of impartiality and (2 impartiality must get rid of the presumption of impartiality.

  7. GLOBALIZATION AND INTEGRATION INTO THE ECONOMIC AND MONETARY UNION-CHALLENGES FOR BANKS OPERATING IN ROMANIA

    Directory of Open Access Journals (Sweden)

    CORALIA EMILIA POPA

    2012-01-01

    Full Text Available This paper aims to present recent evolution, but also the consequences of globalization of the banking sector, considering different approaches of this phenomenon. Over time, the banking field has undergone important changes in both the applicable law of this area, and through the technologies used in satisfying the customers’ needs. The development of international markets has led to new opportunities and challenges for banks that transformed the domestic financial market into an arena where only the best survive and grow. On these grounds and in strict relation to positive and negative effects of globalization, we can speak of a constant evolution of its most important subsystems - the financial subsystems of the global economy. In this paper special importance is given to the banking field, the article presenting arguments through which this complex phenomenon called globalization may have important consequences on financial supervision and regulation.

  8. Striking a Better Integration of Work and Life: Challenges and Solutions.

    Science.gov (United States)

    Cheesborough, Jennifer E; Gray, Sylvia S; Bajaj, Anureet K

    2017-02-01

    Plastic surgeons are a diverse group but share a drive for excellence and dedication to their patients and the advancement of the specialty. Long hours at work and the need to be on call have limited the time that many have to spend on activities outside of the workplace. Reconciliation of the demands of surgery and private life can at times seem impossible. A failure to achieve balance between work and home life is associated with reduced job and life satisfaction, impaired mental health, family conflict, and ultimately burnout. Although the obstacles are many and varied, the authors have attempted to identify the challenges and propose solutions. The authors focus on women in plastic surgery in this article, but acknowledge that these issues are not unique to women or plastic surgery.

  9. Integration in power control systems. The answer to increasing challenges in grid operation; Integration in der Netzleittechnik. Die Antwort auf die zunehmende Aufgabenvielfalt im Netzbetrieb

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Matthias [IDS GmbH, Ettlingen (Germany)

    2011-07-01

    Today, grid operators are faced with increasingly complex tasks that go well beyond the actual scope of grid control. On the one hand, these challenges arise from the permanently increasing number of decentralized power supplies in the m.v. and l.v. network and their automation, and, on the other hand, from grid expansion which has created new supply areas. Frequently, the information required for the different tasks is not available in the control system, or can only be obtained with considerable effort from other IT solutions (e.g. GIS or ERP). Therefore, it is important to provide all the required data from a variety of different systems in a user-friedly and compatible form. The following paper outlines an integrative solution for the networking of different IT systems, for increased efficiency in network operation. (orig.)

  10. Developing support schemes for electric renewable energy in France: how to reconcile integration and deployment challenges?

    International Nuclear Information System (INIS)

    Mathieu, Mathilde; Ruedinger, Andreas

    2016-01-01

    The reform for a greater integration of support schemes in the electricity market is not a marginal development, and should allow for a transition period for market actors to adapt. Lessons from the experience of neighboring countries will be valuable, especially in view of greater regional harmonization in the future. Better integration of solutions for reducing demand and greater system flexibility would also be advisable going forward. Finally, it is also essential to evaluate the impact of the reform on the risk of electricity market concentration and a reduced diversity of actors; as well as of the potential increase in barriers to entry which could hinder the emergence of collaborative or citizen projects, as these are crucial for improving project acceptance and sharing RES costs. Through stronger exposure to market signals, market premia can assist the technical and economic integration of renewable energy (RES). The resultant advantages in terms of improvements in forecasting and marketing tools, negative price management and support for more valuable technologies and practices in the system closely depends, however, on the precise calibration of the mechanisms involved. To address this, it seems essential to learn from the experiences of neighboring countries and to plan an adequate transition period for all actors to adapt to the change in regulation. The rise in transaction costs and risk premia can lead to additional costs under the new mechanisms. Direct costs, which are linked to the marketing of electricity and to rules aimed at curtailing negative prices, remain limited. However, a cost-benefit analysis must consider the impact of changes in regulation on risk perception and the cost of capital for financing projects - a determinant factor in the economic viability of the project. This further implies a need to consider complementary measures aimed at reducing the financial risks to limit production costs and incremental costs for society. The push

  11. Electronic patient information systems and care pathways: the organisational challenges of implementation and integration.

    Science.gov (United States)

    Dent, Mike; Tutt, Dylan

    2014-09-01

    Our interest here is with the 'marriage' of e-patient information systems with care pathways in order to deliver integrated care. We report on the development and implementation of four such pathways within two National Health Service primary care trusts in England: (a) frail elderly care, (b) stroke care, (c) diabetic retinopathy screening and (d) intermediate care. The pathways were selected because each represents a different type of information and data 'couplings', in terms of task interdependency with some pathways/systems reflecting more complex coordinating patterns than others. Our aim here is identify and explain how health professionals and information specialists in two organisational National Health Service primary care trusts organisationally construct and use such systems and, in particular, the implications this has for issues of professional and managerial control and autonomy. The article is informed by an institutionalist analysis. © The Author(s) 2013.

  12. Biomedical text mining for research rigor and integrity: tasks, challenges, directions.

    Science.gov (United States)

    Kilicoglu, Halil

    2017-06-13

    An estimated quarter of a trillion US dollars is invested in the biomedical research enterprise annually. There is growing alarm that a significant portion of this investment is wasted because of problems in reproducibility of research findings and in the rigor and integrity of research conduct and reporting. Recent years have seen a flurry of activities focusing on standardization and guideline development to enhance the reproducibility and rigor of biomedical research. Research activity is primarily communicated via textual artifacts, ranging from grant applications to journal publications. These artifacts can be both the source and the manifestation of practices leading to research waste. For example, an article may describe a poorly designed experiment, or the authors may reach conclusions not supported by the evidence presented. In this article, we pose the question of whether biomedical text mining techniques can assist the stakeholders in the biomedical research enterprise in doing their part toward enhancing research integrity and rigor. In particular, we identify four key areas in which text mining techniques can make a significant contribution: plagiarism/fraud detection, ensuring adherence to reporting guidelines, managing information overload and accurate citation/enhanced bibliometrics. We review the existing methods and tools for specific tasks, if they exist, or discuss relevant research that can provide guidance for future work. With the exponential increase in biomedical research output and the ability of text mining approaches to perform automatic tasks at large scale, we propose that such approaches can support tools that promote responsible research practices, providing significant benefits for the biomedical research enterprise. Published by Oxford University Press 2017. This work is written by a US Government employee and is in the public domain in the US.

  13. Integrating Postsecondary Education Interventions to Help Low-Income Students Succeed. Testimony of Alexander Mayer, Deputy Director, Postsecondary Education, MDRC, Before the California State Assembly Higher Education Committee and the Budget Subcommittee on Education Finance

    Science.gov (United States)

    Mayer, Alexander

    2018-01-01

    This document presents the testimony of MDRC's Alex Mayer, the Deputy Director for Postsecondary Education at MDRC. The three points that Alex Mayer emphasizes in this testimony before the California State Assembly Higher Education Committee and the Budget Subcommittee on Education Finance on integrating postsecondary education interventions to…

  14. Nuclear Power Plant Life Management - Challenges and Proposal for a Unified Model Integrating Safety and Economics

    International Nuclear Information System (INIS)

    Contri, Paolo; Elsing, Bernhard

    2011-01-01

    In recent years many electric utilities and nuclear power plants adopted policies for improved coordination of both safety and non-safety programs, called plant life management (PLIM), also in view on plant life extension programs, but mainly for an optimisation of operating costs. The implementation of PLIM programs has followed many different approaches, being intrinsically dependent on the national regulatory framework and technical traditions. In Countries with some experience, the PLIM program proved very convenient, especially when coupled with Maintenance, Surveillance an Inspection (MS and I) optimization: average savings are reported in the range of 20-30% of total (maintenance) costs. A unified European model for PLIM was developed at the JRC-Institute for Energy with the support of a network of stakeholders (SENUF), and validated at some EU nuclear plants. This paper provides a summary of the model features, the result of its validation at some plants and summarises the perceived scientific/technological challenges on which JRC proposes to focus, based upon its competencies and skills, having in mind both the European and world-wide context and its potential evolution. (author)

  15. Electric energy restructuring in the European Union: Integration, subsidiarity and the challenge of harmonization

    International Nuclear Information System (INIS)

    Serralles, Roberto J.

    2006-01-01

    In 1996, the European Union (EU) instituted Directive 96/92/EC that aims to establish a competitive, secure and transparent EU-wide internal electric energy market. The process of electricity market restructuring in the EU is being guided primarily by the principle of subsidiarity. As an organizational concept, the principle of subsidiarity allows Member States to establish their own implementation strategies and methods as a means of achieving the EU-mandated goal of electric energy restructuring. Historically, the structure of the electric energy industry in place among the Member States exhibited widely disparate organizational and functional characteristics with regard to ownership, control and regulation. Under these varied and contrasting political and economic conditions, the goal of a EU-wide harmonized electric energy market becomes very challenging. In this paper, I describe the policy mechanisms and the market conditions mandated by the EU directive aimed at liberalizing the electric energy market. I then assess the role of political culture, historical resource endowment and geographical conditions in the utility restructuring strategies of some key Member States and its effects on the overall goals of a harmonized internal electric energy market. Finally, I argue that European electric energy restructuring must be understood within the context of the political and economic milieu that spawned the individual Member States' electric energy industry

  16. Electric energy restructuring in the European Union: integration, subsidiarity and the challenge of harmonization

    International Nuclear Information System (INIS)

    Serralles, R.J.

    2006-01-01

    In 1996, the European Union (EU) instituted Directive 96/92/EC that aims to establish a competitive, secure and transparent EU-wide internal electric energy market. The process of electricity market restructuring in the EU is being guided primarily by the principle of subsidiarity. As an organizational concept, the principle of subsidiarity allows Member States to establish their own implementation strategies and methods as a means of achieving the EU-mandated goal of electric energy restructuring. Historically, the structure of the electric energy industry in place among the Member States exhibited widely disparate organizational and functional characteristics with regard to ownership, control and regulation. Under these varied and contrasting political and economic conditions, the goal of a EU-wide harmonized electric energy market becomes very challenging. In this paper, I describe the policy mechanisms and the market conditions mandated by the EU directive aimed at liberalizing the electric energy market. I then assess the role of political culture, historical resource endowment and geographical conditions in the utility restructuring strategies of some key Member States and its effects on the overall goals of a harmonized internal electric energy market. Finally, I argue that European electric energy restructuring must be understood within the context of the political and economic milieu that spawned the individual Member States' electric energy industry. (author)

  17. Challenges in Wireless System Integration as Enablers for Indoor Context Aware Environments

    Directory of Open Access Journals (Sweden)

    Peio López-Iturri

    2017-07-01

    Full Text Available The advent of fully interactive environments within Smart Cities and Smart Regions requires the use of multiple wireless systems. In the case of user-device interaction, which finds multiple applications such as Ambient Assisted Living, Intelligent Transportation Systems or Smart Grids, among others, large amount of transceivers are employed in order to achieve anytime, anyplace and any device connectivity. The resulting combination of heterogeneous wireless network exhibits fundamental limitations derived from Coverage/Capacity relations, as a function of required Quality of Service parameters, required bit rate, energy restrictions and adaptive modulation and coding schemes. In this context, inherent transceiver density poses challenges in overall system operation, given by multiple node operation which increases overall interference levels. In this work, a deterministic based analysis applied to variable density wireless sensor network operation within complex indoor scenarios is presented, as a function of topological node distribution. The extensive analysis derives interference characterizations, both for conventional transceivers as well as wearables, which provide relevant information in terms of individual node configuration as well as complete network layout.

  18. Artificial Post mining lakes - a challenge for the integration in natural hydrography and river basin management

    Science.gov (United States)

    Fleischhammel, Petra; Schoenheinz, Dagmar; Grünewald, Uwe

    2010-05-01

    In terms of the European Water Framework Directive (WFD), post mining lakes are artificial water bodies (AWB). The sustainable integration of post mining lakes in the groundwater and surface water landscape and their consideration in river basin management plans have to be linked with various (geo)hydrological, hydro(geo)chemical, technological and socioeconomic issues. The Lower Lusatian lignite mining district in eastern Germany is part of the major river basins of river Elbe and river Oder. Regionally, the mining area is situated in the sub-basins of river Spree and Schwarze Elster. After the cessation of mining activities and thereby of the artificially created groundwater drawdown in numerous mining pits, a large number of post mining lakes are evolving as consequence of natural groundwater table recovery. The lakes' designated uses vary from water reservoirs to landscape, recreation or fish farming lakes. Groundwater raise is not only substantial for the lake filling, but also for the area rehabilitation and a largely self regulated water balance in post mining landscapes. Since the groundwater flow through soil and dump sites being affected by the former mining activities, groundwater experiences various changes in its hydrochemical properties as e.g. mineralization and acidification. Consequently, downstream located groundwater fed running and standing water bodies will be affected too. Respective the European Water Framework Directive, artificial post mining lakes are not allowed to cause significant adverse impacts on the good ecological status/potential of downstream groundwater and surface water bodies. The high sulphate concentrations of groundwater fed mining lakes which reach partly more than 1,000 mg/l are e.g. damaging concrete constructures in downstream water bodies thereby representing threats for hydraulic facilities and drinking water supply. Due to small amounts of nutrients, the lakes are characterised by oligo¬trophic to slightly

  19. Nanoparticle assemblies and superstructures

    National Research Council Canada - National Science Library

    Kotov, Nicholas A

    2006-01-01

    ... building blocks of larger and more complex systems. Therefore, the present challenge of nanoscale science is to shift from making certain building blocks to organizing them in one-, two-, and three-dimensional structures. Such assemblies and superstructures are the next logical step in the development of nanoscience and nanotechnology. In this re...

  20. Biosynthesis: Reprogramming assembly lines

    Science.gov (United States)

    Menon, Binuraj R. K.; Jenner, Matthew

    2018-03-01

    Rational engineering of biosynthetic assembly lines for production of new compounds is an attractive prospect, yet it presents many challenges. Learning from biology, some of the rules for expanding the chemical diversity of non-ribosomal peptides have been uncovered in two recent studies.

  1. Challenges of commissioning and contracting for integrated care in the National Health Service (NHS) in England.

    Science.gov (United States)

    Addicott, Rachael

    2016-01-01

    For many years there has been a separation between purchasing and provision of services in the English National Health Service (NHS). Many studies report that this commissioning function has been weak: purchasers have had little impact or power in negotiations with large acute providers, and have had limited strategic control over the delivery of care. Nevertheless, commissioning has become increasingly embedded in the NHS structure since the arrival of Clinical Commissioning Groups (CCGs) in 2012. Recently, some of these CCGs have focused on how they can contract and commission in different ways to stimulate greater collaboration across providers. This paper examines experiences of commissioning and contracting for integrated care in the English NHS, based on a series of national-level interviews and case studies of five health economies that are implementing novel contracting models. The cases illustrated here demonstrate early experiments to drive innovation through contracting in the NHS that have largely relied on the vision of individual teams or leaders, in combination with external legal, procurement and actuarial support. It is unlikely that this approach will be sustainable or replicable across the country or internationally, despite the best intentions of commissioners. Designing and operating novel contractual approaches will require considerable determination, alongside advanced skills in procurement, contract management and commissioning. The cost of developing new contractual approaches is high, and as the process is difficult and resource-intensive, it is likely that dedicated teams or programs will be required to drive significant improvement.

  2. GEOREFERENCING IN GNSS-CHALLENGED ENVIRONMENT: INTEGRATING UWB AND IMU TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    C. K. Toth

    2017-05-01

    Full Text Available Acquiring geospatial data in GNSS compromised environments remains a problem in mapping and positioning in general. Urban canyons, heavily vegetated areas, indoor environments represent different levels of GNSS signal availability from weak to no signal reception. Even outdoors, with multiple GNSS systems, with an ever-increasing number of satellites, there are many situations with limited or no access to GNSS signals. Independent navigation sensors, such as IMU can provide high-data rate information but their initial accuracy degrades quickly, as the measurement data drift over time unless positioning fixes are provided from another source. At The Ohio State University’s Satellite Positioning and Inertial Navigation (SPIN Laboratory, as one feasible solution, Ultra- Wideband (UWB radio units are used to aid positioning and navigating in GNSS compromised environments, including indoor and outdoor scenarios. Here we report about experiences obtained with georeferencing a pushcart based sensor system under canopied areas. The positioning system is based on UWB and IMU sensor integration, and provides sensor platform orientation for an electromagnetic inference (EMI sensor. Performance evaluation results are provided for various test scenarios, confirming acceptable results for applications where high accuracy is not required.

  3. AppEEARS: A Simple Tool that Eases Complex Data Integration and Visualization Challenges for Users

    Science.gov (United States)

    Maiersperger, T.

    2017-12-01

    The Application for Extracting and Exploring Analysis-Ready Samples (AppEEARS) offers a simple and efficient way to perform discovery, processing, visualization, and acquisition across large quantities and varieties of Earth science data. AppEEARS brings significant value to a very broad array of user communities by 1) significantly reducing data volumes, at-archive, based on user-defined space-time-variable subsets, 2) promoting interoperability across a wide variety of datasets via format and coordinate reference system harmonization, 3) increasing the velocity of both data analysis and insight by providing analysis-ready data packages and by allowing interactive visual exploration of those packages, and 4) ensuring veracity by making data quality measures more apparent and usable and by providing standards-based metadata and processing provenance. Development and operation of AppEEARS is led by the National Aeronautics and Space Administration (NASA) Land Processes Distributed Active Archive Center (LP DAAC). The LP DAAC also partners with several other archives to extend the capability across a larger federation of geospatial data providers. Over one hundred datasets are currently available, covering a diversity of variables including land cover, population, elevation, vegetation indices, and land surface temperature. Many hundreds of users have already used this new web-based capability to make the complex tasks of data integration and visualization much simpler and more efficient.

  4. Quantitative Evaluation of Performance in Interventional Neuroradiology: An Integrated Curriculum Featuring Theoretical and Practical Challenges.

    Directory of Open Access Journals (Sweden)

    Marielle Ernst

    Full Text Available We sought to develop a standardized curriculum capable of assessing key competencies in Interventional Neuroradiology by the use of models and simulators in an objective, quantitative, and efficient way. In this evaluation we analyzed the associations between the practical experience, theoretical knowledge, and the skills lab performance of interventionalists.We evaluated the endovascular skills of 26 participants of the Advanced Course in Endovascular Interventional Neuroradiology of the European Society of Neuroradiology with a set of three tasks (aneurysm coiling and thrombectomy in a virtual simulator and placement of an intra-aneurysmal flow disruptor in a flow model. Practical experience was assessed by a survey. Participants completed a written and oral examination to evaluate theoretical knowledge. Bivariate and multivariate analyses were performed.In multivariate analysis knowledge of materials and techniques in Interventional Neuroradiology was moderately associated with skills in aneurysm coiling and thrombectomy. Experience in mechanical thrombectomy was moderately associated with thrombectomy skills, while age was negatively associated with thrombectomy skills. We found no significant association between age, sex, or work experience and skills in aneurysm coiling.Our study gives an example of how an integrated curriculum for reasonable and cost-effective assessment of key competences of an interventional neuroradiologist could look. In addition to traditional assessment of theoretical knowledge practical skills are measured by the use of endovascular simulators yielding objective, quantitative, and constructive data for the evaluation of the current performance status of participants as well as the evolution of their technical competency over time.

  5. Organizational factors, planning capacity, and integration challenges constrain provincial planning processes for nutrition in decentralizing Vietnam.

    Science.gov (United States)

    Lapping, Karin; Frongillo, Edward A; Nguyen, Phuong H; Coates, Jennifer; Webb, Patrick; Menon, Purnima

    2014-09-01

    Translating national policies and guidelines into effective action at the subnational level (e.g., province or region) is a prerequisite for ensuring an impact on nutrition. In several countries, including Vietnam, the focus of this paper, this process is affected by the quality of the decentralized process of planning and action. This study examined how provincial planning processes for nutrition occurred in Vietnam during 2009 and 2010. Key goals were to understand variability in processes across provinces, identify factors that influenced the process, and assess the usefulness of the process for individuals involved in planning and action. A qualitative case-study methodology was used. Data were drawn from interviews with 51 government officials in eight provinces. The study found little variability in the planning process among these eight provinces, probably due to a planning process that was predominantly a fiscal exercise within the confines of a largely centralized structure. Respondents were almost unanimous about the main barriers: a top-down approach to planning, limited human capacity for effective planning at subnational levels, and difficulty in integrating actions from multiple sectors. Provincial-level actors were deeply dissatisfied with the nature of their role in the process. Despite the rhetoric to the contrary, too much power is probably still retained at the central level. A strategic multiyear approach is needed to strengthen the provincial planning process and address many of the key barriers identified in this study.

  6. School Integration Program in Chile: gaps and challenges for the implementation of an inclusive education program

    Directory of Open Access Journals (Sweden)

    Mauro Tamayo Rozas

    2018-06-01

    Full Text Available Constructing inclusive societies, leaving no one behind, it is an ethical obligation. Developing inclusive educational programs allows ensuring equal opportunities in one of the most critical stages of development. The aim of this study is to describe the implementation of the School Integration Program (SIP in its different dimensions and in different zones of Chile. A descriptive and cross-sectional study of the perception of SIP Coordinators was performed in public and subsidized schools at the country through a web-based survey. A simple random convenience sampling of schools was performed, obtaining 1742 answers from educational establishments with SIP. Higher level of implementation of the program was identified in areas related to interdisciplinary work and comprehensive training, curricular and institutional aspects. On the other hand, deficiencies were identified in the implementation of accessibility, development of reasonable adjustments and participation of the educational community. Likewise, there are differences between the zones of Chile, with the North zone having the least progress. Although there are results in the work team and institutional development, the development of objective conditions and participation is still a pending task in the implementation of the SIP.

  7. Biomedical Applications of Self-Assembling Peptides

    NARCIS (Netherlands)

    Radmalekshahi, Mazda; Lempsink, Ludwijn; Amidi, Maryam; Hennink, Wim E.; Mastrobattista, Enrico

    2016-01-01

    Self-assembling peptides have gained increasing attention as versatile molecules to generate diverse supramolecular structures with tunable functionality. Because of the possibility to integrate a wide range of functional domains into self-assembling peptides including cell attachment sequences,

  8. Coupled Data Assimilation for Integrated Earth System Analysis and Prediction: Goals, Challenges, and Recommendations

    Science.gov (United States)

    Penny, Stephen G.; Akella, Santha; Buehner, Mark; Chevallier, Matthieu; Counillon, Francois; Draper, Clara; Frolov, Sergey; Fujii, Yosuke; Karspeck, Alicia; Kumar, Arun

    2017-01-01

    The purpose of this report is to identify fundamental issues for coupled data assimilation (CDA), such as gaps in science and limitations in forecasting systems, in order to provide guidance to the World Meteorological Organization (WMO) on how to facilitate more rapid progress internationally. Coupled Earth system modeling provides the opportunity to extend skillful atmospheric forecasts beyond the traditional two-week barrier by extracting skill from low-frequency state components such as the land, ocean, and sea ice. More generally, coupled models are needed to support seamless prediction systems that span timescales from weather, subseasonal to seasonal (S2S), multiyear, and decadal. Therefore, initialization methods are needed for coupled Earth system models, either applied to each individual component (called Weakly Coupled Data Assimilation - WCDA) or applied the coupled Earth system model as a whole (called Strongly Coupled Data Assimilation - SCDA). Using CDA, in which model forecasts and potentially the state estimation are performed jointly, each model domain benefits from observations in other domains either directly using error covariance information known at the time of the analysis (SCDA), or indirectly through flux interactions at the model boundaries (WCDA). Because the non-atmospheric domains are generally under-observed compared to the atmosphere, CDA provides a significant advantage over single-domain analyses. Next, we provide a synopsis of goals, challenges, and recommendations to advance CDA: Goals: (a) Extend predictive skill beyond the current capability of NWP (e.g. as demonstrated by improving forecast skill scores), (b) produce physically consistent initial conditions for coupled numerical prediction systems and reanalyses (including consistent fluxes at the domain interfaces), (c) make best use of existing observations by allowing observations from each domain to influence and improve the full earth system analysis, (d) develop a robust

  9. CHALLENGES AND OPPORTUNITIES--INTEGRATED LIFE-CYCLE OPTIMIZATION INITIATIVES FOR THE HANFORD RIVER PROTECTION PROJECT--WASTE TREATMENT PLANT

    International Nuclear Information System (INIS)

    Auclair, K. D.

    2002-01-01

    This paper describes the ongoing integrated life-cycle optimization efforts to achieve both design flexibility and design stability for activities associated with the Waste Treatment Plant at Hanford. Design flexibility is required to support the Department of Energy Office of River Protection Balance of Mission objectives, and design stability to meet the Waste Treatment Plant construction and commissioning requirements in order to produce first glass in 2007. The Waste Treatment Plant is a large complex project that is driven by both technology and contractual requirements. It is also part of a larger overall mission, as a component of the River Protection Project, which is driven by programmatic requirements and regulatory, legal, and fiscal constraints. These issues are further complicated by the fact that both of the major contractors involved have a different contract type with DOE, and neither has a contract with the other. This combination of technical and programmatic drivers, constraints, and requirements will continue to provide challenges and opportunities for improvement and optimization. The Bechtel National, Inc. team is under contract to engineer, procure, construct, commission and test the Waste Treatment Plant on or ahead of schedule, at or under cost, and with a throughput capacity equal to or better than specified. The Department of Energy is tasked with the long term mission of waste retrieval, treatment, and disposal. While each mission is a compliment and inextricably linked to one another, they are also at opposite ends of the spectrum, in terms of expectations of one another. These mission requirements, that are seemingly in opposition to one another, pose the single largest challenge and opportunity for optimization: one of balance. While it is recognized that design maturation and optimization are the normal responsibility of any engineering firm responsible for any given project, the aspects of integrating requirements and the management

  10. Autism, an extreme challenge to integrative medicine. Part 2: medical management.

    Science.gov (United States)

    Kidd, Parris M

    2002-12-01

    Autism and allied autistic spectrum disorders (ASD) present myriad behavioral, clinical, and biochemical abnormalities. Parental participation, advanced testing protocols, and eclectic treatment strategies have driven progress toward cure. Behavioral modification and structured education are beneficial but insufficient. Dietary restrictions, including removal of milk and other casein dairy products, wheat and other gluten sources, sugar, chocolate, preservatives, and food coloring are beneficial and prerequisite to benefit from other interventions. Individualized IgG or IgE testing can identify other troublesome foods but not non-immune mediated food sensitivities. Gastrointestinal improvement rests on controlling Candida and other parasites, and using probiotic bacteria and nutrients to correct dysbiosis and decrease gut permeability. Detoxification of mercury and other heavy metals by DMSA/DMPS chelation can have marked benefit. Documented sulfoxidation-sulfation inadequacies call for sulfur-sulfhydryl repletion and other liver p450 support. Many nutrient supplements are beneficial and well tolerated, including dimethylglycine (DMG) and a combination of pyridoxine (vitamin B6) and magnesium, both of which benefit roughly half of ASD cases. Vitamins A, B3, C, and folic acid; the minerals calcium and zinc; cod liver oil; and digestive enzymes, all offer benefit. Secretin, a triggering factor for digestion, is presently under investigation. Immune therapies (pentoxifyllin, intravenous immunoglobulin, transfer factor, and colostrum) benefit selected cases. Long-chain omega-3 fatty acids offer great promise. Current pharmaceuticals fail to benefit the primary symptoms and can have marked adverse effects. Individualized, in-depth clinical and laboratory assessments and integrative parent-physician-scientist cooperation are the keys to successful ASD management.

  11. Integration of Plant Defense Traits with Biological Control of Arthropod Pests: Challenges and Opportunities.

    Science.gov (United States)

    Peterson, Julie A; Ode, Paul J; Oliveira-Hofman, Camila; Harwood, James D

    2016-01-01

    Crop plants exhibit a wide diversity of defensive traits and strategies to protect themselves from damage by herbivorous pests and disease. These defensive traits may be naturally occurring or artificially selected through crop breeding, including introduction via genetic engineering. While these traits can have obvious and direct impacts on herbivorous pests, many have profound effects on higher trophic levels, including the natural enemies of herbivores. Multi-trophic effects of host plant resistance have the potential to influence, both positively and negatively, biological control. Plant defense traits can influence both the numerical and functional responses of natural enemies; these interactions can be semiochemically, plant toxin-, plant nutrient-, and/or physically mediated. Case studies involving predators, parasitoids, and pathogens of crop pests will be presented and discussed. These diverse groups of natural enemies may respond differently to crop plant traits based on their own unique biology and the ecological niches they fill. Genetically modified crop plants that have been engineered to express transgenic products affecting herbivorous pests are an additional consideration. For the most part, transgenic plant incorporated protectant (PIP) traits are compatible with biological control due to their selective toxicity to targeted pests and relatively low non-target impacts, although transgenic crops may have indirect effects on higher trophic levels and arthropod communities mediated by lower host or prey number and/or quality. Host plant resistance and biological control are two of the key pillars of integrated pest management; their potential interactions, whether they are synergistic, complementary, or disruptive, are key in understanding and achieving sustainable and effective pest management.

  12. Integration of plant defense traits with biological control of arthropod pests: challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Julie A Peterson

    2016-11-01

    Full Text Available Crop plants exhibit a wide diversity of defensive traits and strategies to protect themselves from damage by herbivorous pests and disease. These defensive traits may be naturally occurring or artificially selected through crop breeding, including introduction via genetic engineering. While these traits can have obvious and direct impacts on herbivorous pests, many have profound effects on higher trophic levels, including the natural enemies of herbivores. Multi-trophic effects of host plant resistance have the potential to influence, both positively and negatively, biological control. Plant defense traits can influence both the numerical and functional responses of natural enemies; these interactions can be semiochemically-, plant toxin-, plant nutrient-, and/or physically-mediated. Case studies involving predators, parasitoids, and pathogens of crop pests will be presented and discussed. These diverse groups of natural enemies may respond differently to crop plant traits based on their own unique biology and the ecological niches they fill. Genetically modified crop plants that have been engineered to express transgenic products affecting herbivorous pests are an additional consideration. For the most part, transgenic plant incorporated protectant (PIP traits are compatible with biological control due to their selective toxicity to targeted pests and relatively low non-target impacts, although transgenic crops may have indirect effects on higher trophic levels and arthropod communities mediated by lower host or prey number and/or quality. Host plant resistance and biological control are two of the key pillars of integrated pest management; their potential interactions, whether they are synergistic, complementary, or disruptive, are key in understanding and achieving sustainable and effective pest management.

  13. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.

    Science.gov (United States)

    Nikonorova, Inna A; Al-Baghdadi, Rana J T; Mirek, Emily T; Wang, Yongping; Goudie, Michael P; Wetstein, Berish B; Dixon, Joseph L; Hine, Christopher; Mitchell, James R; Adams, Christopher M; Wek, Ronald C; Anthony, Tracy G

    2017-04-21

    Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but the mechanism is unknown. Asparaginase activates the integrated stress response (ISR) via sensing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2. The goal of this work was to discern the impact of obesity, alone versus alongside genetic disruption of the ISR, on mechanisms of liver protection during chronic asparaginase exposure in mice. Following diet-induced obesity, biochemical analysis of livers revealed that asparaginase provoked hepatic steatosis that coincided with activation of another eIF2 kinase PKR-like endoplasmic reticulum kinase (PERK), a major ISR transducer to ER stress. Genetic loss of Gcn2 intensified hepatic PERK activation to asparaginase, yet surprisingly, mRNA levels of key ISR gene targets such as Atf5 and Trib3 failed to increase. Instead, mechanistic target of rapamycin complex 1 (mTORC1) signal transduction was unleashed, and this coincided with liver dysfunction reflected by a failure to maintain hydrogen sulfide production or apolipoprotein B100 (ApoB100) expression. In contrast, obese mice lacking hepatic activating transcription factor 4 ( Atf4 ) showed an exaggerated ISR and greater loss of endogenous hydrogen sulfide but normal inhibition of mTORC1 and maintenance of ApoB100 during asparaginase exposure. In both genetic mouse models, expression and phosphorylation of Sestrin2, an ATF4 gene target, was increased by asparaginase, suggesting mTORC1 inhibition during asparaginase exposure is not driven via eIF2-ATF4-Sestrin2. In conclusion, obesity promotes a maladaptive ISR during asparaginase exposure. GCN2 functions to repress mTORC1 activity and maintain ApoB100 protein levels independently of Atf4 expression, whereas hydrogen sulfide production is promoted via GCN2-ATF4 pathway. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. Policy challenges facing integrated community case management in Sub-Saharan Africa.

    Science.gov (United States)

    Bennett, Sara; George, Asha; Rodriguez, Daniela; Shearer, Jessica; Diallo, Brahima; Konate, Mamadou; Dalglish, Sarah; Juma, Pamela; Namakhoma, Ireen; Banda, Hastings; Chilundo, Baltazar; Mariano, Alda; Cliff, Julie

    2014-07-01

    To report an in-depth analysis of policy change for integrated community case management of childhood illness (iCCM) in six sub-Saharan African countries. We analysed how iCCM policies developed and the barriers and facilitators to policy change. Qualitative retrospective case studies drawing from document reviews, semi-structured interviews and in-country validation workshops were conducted in Burkina Faso, Kenya, Malawi, Mali, Mozambique and Niger. These countries were selected to maximise variation in iCCM policy status, community health worker (CHW) models and different African regions. Country iCCM policies evolved in an ad hoc fashion, but were substantially influenced by the history of primary health care and the nature of CHW programmes. Technical officers within Ministries of Health led iCCM policy change with support from international donors, but neither communities nor political leadership was mobilised. Concerns about achieving the Millennium Development Goals, together with recognition of the shortcomings of existing child health programmes, led to the adoption of iCCM policies. Availability of external financing played a critical role in facilitating policy change. iCCM policy change has been promoted by international agencies, but national governments have struggled to align iCCM with country health systems. Greater investment is needed in tailoring global policy initiatives to match country needs. High-level, political ownership of iCCM policies could facilitate policy change, as could clearer strategies for ensuring the long-term sustainability of such policies. © 2014 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

  15. Drilling Specifications: Well Installations in the 300 Area to Support PNNL's Integrated Field-Scale Subsurface Research Challenge (IFC) Project

    International Nuclear Information System (INIS)

    Bjornstad, Bruce N.; Vermeul, Vince R.

    2008-01-01

    Part of the 300 Area Integrated Field-Scale Subsurface Research Challenge (IFC) will be installation of a network of high density borings and wells to monitor migration of fluids and contaminants (uranium), both in groundwater and vadose zone, away from an surface infiltration plot (Figure A-1). The infiltration plot will be located over an area of suspected contamination at the former 300 Area South Process Pond (SPP). The SPP is located in the southeastern portion of the Hanford Site, within the 300-FF-5 Operable Unit. Pacific Northwest National Laboratory (PNNL) with the support of FH shall stake the well locations prior to the start of drilling. Final locations will be based on accessibility and will avoid any surface or underground structures or hazards as well as surface contamination

  16. Formulating the American Geophysical Union's Scientific Integrity and Professional Ethics Policy: Challenges and lessons learned: Chapter 8

    Science.gov (United States)

    Gundersen, Linda C.; Townsend, Randy

    2017-01-01

    Creating an ethics policy for a large, diverse geosciences organization is a challenge, especially in the midst of the current contentious dialogue in the media related to such issues as climate change, sustaining natural resources, and responding to natural hazards. In 2011, the American Geophysical Union (AGU) took on this challenge, creating an Ethics Task Force to update their ethics policies to better support their new Strategic Plan and respond to the changing scientific research environment. Dialogue with AGU members and others during the course of creating the new policy unveiled some of the following issues to be addressed. Scientific results and individual scientists are coming under intense political and public scrutiny, with the efficacy of the science being questioned. In some cases, scientists are asked to take sides and/or provide opinions on issues beyond their research, impacting their objectivity. Pressure related to competition for funding and the need to publish high quality and quantities of papers has led to recent high profile plagiarism, data fabrication, and conflict of interest cases. The complexities of a continuously advancing digital environment for conducting, reviewing, and publishing science has raised concerns over the ease of plagiarism, fabrication, falsification, inappropriate peer review, and the need for better accessibility of data and methods. Finally, students and scientists need consistent education and encouragement on the importance of ethics and integrity in scientific research. The new AGU Scientific Integrity and Ethics Policy tries to address these issues and provides an inspirational code of conduct to encourage a responsible, positive, open, and honest scientific research environment.

  17. Gene expression prediction by soft integration and the elastic net-best performance of the DREAM3 gene expression challenge.

    Directory of Open Access Journals (Sweden)

    Mika Gustafsson

    Full Text Available BACKGROUND: To predict gene expressions is an important endeavour within computational systems biology. It can both be a way to explore how drugs affect the system, as well as providing a framework for finding which genes are interrelated in a certain process. A practical problem, however, is how to assess and discriminate among the various algorithms which have been developed for this purpose. Therefore, the DREAM project invited the year 2008 to a challenge for predicting gene expression values, and here we present the algorithm with best performance. METHODOLOGY/PRINCIPAL FINDINGS: We develop an algorithm by exploring various regression schemes with different model selection procedures. It turns out that the most effective scheme is based on least squares, with a penalty term of a recently developed form called the "elastic net". Key components in the algorithm are the integration of expression data from other experimental conditions than those presented for the challenge and the utilization of transcription factor binding data for guiding the inference process towards known interactions. Of importance is also a cross-validation procedure where each form of external data is used only to the extent it increases the expected performance. CONCLUSIONS/SIGNIFICANCE: Our algorithm proves both the possibility to extract information from large-scale expression data concerning prediction of gene levels, as well as the benefits of integrating different data sources for improving the inference. We believe the former is an important message to those still hesitating on the possibilities for computational approaches, while the latter is part of an important way forward for the future development of the field of computational systems biology.

  18. Integrated study of Mediterranean deep canyons: Novel results and future challenges

    Science.gov (United States)

    Canals, M.; Company, J. B.; Martín, D.; Sànchez-Vidal, A.; Ramírez-Llodrà, E.

    2013-11-01

    intermediate and deep-water masses, and the associated fluxes of matter and energy are a main driver of deep-sea ecosystems; (iv) deep-sea organisms are highly sensitive to the arrival of external inputs, starting from the lowest food web levels and propagating upwards as time passes, which also relies upon the biology, nutritional needs and life expectancy of each individual species; and (v) innovative knowledge gained through such multidisciplinary research is of the utmost significance for an improved management of deep-sea living resources, such as the highly priced red shrimp Aristeus antennatus, for which a pilot management plan largely based in the findings described here and in related articles has been recently published (BOE, 2013). The researchers involved in such challenging endeavour have learnt tremendously from the results obtained so far and from each other, but are fully aware that there are still many unsolved questions. That is why this introductory article also includes “Future challenges” both in the title and as an individual section at the end, to express that there is still a long way to go.

  19. Electric Field Guided Assembly of One-Dimensional Nanostructures for High Performance Sensors

    Directory of Open Access Journals (Sweden)

    Wing Kam Liu

    2012-05-01

    Full Text Available Various nanowire or nanotube-based devices have been demonstrated to fulfill the anticipated future demands on sensors. To fabricate such devices, electric field-based methods have demonstrated a great potential to integrate one-dimensional nanostructures into various forms. This review paper discusses theoretical and experimental aspects of the working principles, the assembled structures, and the unique functions associated with electric field-based assembly. The challenges and opportunities of the assembly methods are addressed in conjunction with future directions toward high performance sensors.

  20. Renewable energy-driven desalination technologies: A comprehensive review on challenges and potential applications of integrated systems

    KAUST Repository

    Ghaffour, Noreddine

    2015-01-01

    Despite the tremendous improvements in conventional desalination technologies, its wide use is still limited due primarily to high energy requirements which are currently met with expensive fossil fuels. The use of alternative energy sources is essential to meet the growing demand for water desalination. In the last few decades a lot of effort has being directed in the use of different renewable energy (RE) sources to run desalination processes. However, the expansion of these efforts towards larger scale plants is hampered by several techno-economic challenges. Several medium-scale RE-driven desalination plants have been installed worldwide. Nevertheless, most of these plants are connected to the electrical grid to assure a continuous energy supply for stable operation. Furthermore, RE is mostly used to produce electric power which can be used to run desalination systems. This review paper focuses on an integrated approach in using RE-driven with an emphasis on solar and geothermal desalination technologies. Innovative and sustainable desalination processes which are suitable for integrated RE systems are presented. An assessment of the benefits of these technologies and their limitations are also discussed.

  1. A review on the geoenvironmental and geoecological integrated technology for environmental remediation in Vietnam: approaches, contributions, challenges and perspectives

    Science.gov (United States)

    Trong Nhuan, Mai; Hoang Ha, Nguyen Thi; Hoai, Ta Thi; Dang Quy, Tran

    2017-06-01

    Geoenvironmental and geoecological integrated technology (GGIT) is a cost-effective and environment-friendly technology that encompasses the applications of earth science principles and functions of geological environment and ecosystems to assimilate and minimize the spread of pollutants, to enhance the sorption capacity and environmental remediation. On the basis of the integrated approaches such as system, anthropogenic activities - ecosystem - environment interaction, effectiveness and feasibility, GGIT has provided significant applications in Vietnam such as waste containment and remediation and environmental protection. The results of a pilot scale using iron mine drainage sludge and common reed (Phragmites australis) for wastewater treatment in a Pb-Zn mine in northern Vietnam indicated the effective and potential application of GGIT. However, GGIT has many challenges in limited funding conditions, constraints in the initial development of GGIT, incomplete transfer to users, and quantitative assessment of pollutant cleanup by natural environments and ecosystems. Environmental pollution quote, impacts to exposed organisms, increasing demands for application of low-cost technologies, the availability of potential sorbents, indigenous plants, and ecosystems for environmental remediation, and collaboration will promote development, contribution, and implementation of GGIT applications in Vietnam.

  2. Challenges in integrative approaches to modelling the marine ecosystems of the North Atlantic: Physics to fish and coasts to ocean

    Science.gov (United States)

    Holt, Jason; Icarus Allen, J.; Anderson, Thomas R.; Brewin, Robert; Butenschön, Momme; Harle, James; Huse, Geir; Lehodey, Patrick; Lindemann, Christian; Memery, Laurent; Salihoglu, Baris; Senina, Inna; Yool, Andrew

    2014-12-01

    It has long been recognised that there are strong interactions and feedbacks between climate, upper ocean biogeochemistry and marine food webs, and also that food web structure and phytoplankton community distribution are important determinants of variability in carbon production and export from the euphotic zone. Numerical models provide a vital tool to explore these interactions, given their capability to investigate multiple connected components of the system and the sensitivity to multiple drivers, including potential future conditions. A major driver for ecosystem model development is the demand for quantitative tools to support ecosystem-based management initiatives. The purpose of this paper is to review approaches to the modelling of marine ecosystems with a focus on the North Atlantic Ocean and its adjacent shelf seas, and to highlight the challenges they face and suggest ways forward. We consider the state of the art in simulating oceans and shelf sea physics, planktonic and higher trophic level ecosystems, and look towards building an integrative approach with these existing tools. We note how the different approaches have evolved historically and that many of the previous obstacles to harmonisation may no longer be present. We illustrate this with examples from the on-going and planned modelling effort in the Integrative Modelling Work Package of the EURO-BASIN programme.

  3. Independent Peer Review of Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) Structural Analysis

    Science.gov (United States)

    Raju, Ivatury S.; Larsen, Curtis E.; Pellicciotti, Joseph W.

    2010-01-01

    Glenn Research Center Chief Engineer's Office requested an independent review of the structural analysis and modeling of the Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) to be conducted by the NASA Engineering and Safety Center (NESC). At this time, the IGA had completed its critical design review (CDR). The assessment was to be a peer review of the NEi-NASTRAN1 model of the APS Antenna, and not a peer review of the design and the analysis that had been completed by the GRC team for CDR. Thus, only a limited amount of information was provided on the structural analysis. However, the NESC team had difficulty separating analysis concerns from modeling issues. The team studied the NASTRAN model, but did not fully investigate how the model was used by the CoNNeCT Project and how the Project was interpreting the results. The team's findings, observations, and NESC recommendations are contained in this report.

  4. Integrated electrochemical gluconic acid biosensor based on self-assembled monolayer-modified gold electrodes. Application to the analysis of gluconic acid in musts and wines.

    Science.gov (United States)

    Campuzano, S; Gamella, M; Serra, B; Reviejo, A J; Pingarrón, J M

    2007-03-21

    An integrated amperometric gluconic acid biosensor constructed using a gold electrode (AuE) modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA) on which gluconate dehydrogenase (GADH, 0.84 U) and the mediator tetrathiafulvalene (TTF, 1.5 micromol) were coimmobilized by covering the electrode surface with a dialysis membrane is reported. The working conditions selected were Eapp=+0.15 V and 25+/-1 degrees C. The useful lifetime of one single TTF-GADH-MPA-AuE was surprisingly long. After 53 days of continuous use, the biosensor exhibited 86% of the original sensitivity. A linear calibration plot was obtained for gluconic acid over the 6.0x10(-7) to 2.0x10(-5) M concentration range, with a limit of detection of 1.9x10(-7) M. The effect of potential interferents (glucose, fructose, galactose, arabinose, and tartaric, citric, malic, ascorbic, gallic, and caffeic acids) on the biosensor response was evaluated. The behavior of the biosensor in a flow-injection system in connection with amperometric detection was tested. The analytical usefulness of the biosensor was evaluated by determining gluconic acid in wine and must samples, and the results obtained were validated by comparison with those provided by using a commercial enzyme test kit.

  5. Self-Assembly of Chip-Size Components with Cavity Structures: High-Precision Alignment and Direct Bonding without Thermal Compression for Hetero Integration

    Directory of Open Access Journals (Sweden)

    Mitsumasa Koyanagi

    2011-02-01

    Full Text Available New surface mounting and packaging technologies, using self-assembly with chips having cavity structures, were investigated for three-dimensional (3D and hetero integration of complementary metal-oxide semiconductors (CMOS and microelectromechanical systems (MEMS. By the surface tension of small droplets of 0.5 wt% hydrogen fluoride (HF aqueous solution, the cavity chips, with a side length of 3 mm, were precisely aligned to hydrophilic bonding regions on the surface of plateaus formed on Si substrates. The plateaus have micro-channels to readily evaporate and fully remove the liquid from the cavities. The average alignment accuracy of the chips with a 1 mm square cavity was found to be 0.4 mm. The alignment accuracy depends, not only on the area of the bonding regions on the substrates and the length of chip periphery without the widths of channels in the plateaus, but also the area wetted by the liquid on the bonding regions. The precisely aligned chips were then directly bonded to the substrates at room temperature without thermal compression, resulting in a high shear bonding strength of more than 10 MPa.

  6. NATpipe: an integrative pipeline for systematical discovery of natural antisense transcripts (NATs) and phase-distributed nat-siRNAs from de novo assembled transcriptomes

    Science.gov (United States)

    Yu, Dongliang; Meng, Yijun; Zuo, Ziwei; Xue, Jie; Wang, Huizhong

    2016-01-01

    Nat-siRNAs (small interfering RNAs originated from natural antisense transcripts) are a class of functional small RNA (sRNA) species discovered in both plants and animals. These siRNAs are highly enriched within the annealed regions of the NAT (natural antisense transcript) pairs. To date, great research efforts have been taken for systematical identification of the NATs in various organisms. However, developing a freely available and easy-to-use program for NAT prediction is strongly demanded by researchers. Here, we proposed an integrative pipeline named NATpipe for systematical discovery of NATs from de novo assembled transcriptomes. By utilizing sRNA sequencing data, the pipeline also allowed users to search for phase-distributed nat-siRNAs within the perfectly annealed regions of the NAT pairs. Additionally, more reliable nat-siRNA loci could be identified based on degradome sequencing data. A case study on the non-model plant Dendrobium officinale was performed to illustrate the utility of NATpipe. Finally, we hope that NATpipe would be a useful tool for NAT prediction, nat-siRNA discovery, and related functional studies. NATpipe is available at www.bioinfolab.cn/NATpipe/NATpipe.zip. PMID:26858106

  7. Human exposure to chemical mixtures: Challenges for the integration of toxicology with epidemiology data in risk assessment.

    Science.gov (United States)

    Hernández, Antonio F; Tsatsakis, Aristidis M

    2017-05-01

    Little is known about the potential adverse effects from longterm exposure to complex mixtures at low doses, close to health-based reference values. Traditional chemical-specific risk assessment based on animal testing may be insufficient and the lack of toxicological studies on chemical mixtures remains a major regulatory challenge. Hence, new methodologies on cumulative risk assessment are being developed but still present major limitations. Evaluation of chemical mixture effects requires an integrated and systematic approach and close collaboration across different scientific fields, particularly toxicology, epidemiology, exposure science, risk assessment and statistics for a proper integration of data from all these disciplines. Well designed and conducted epidemiological studies can take advantage of this new paradigm and can provide insight to support the correlation between humans low-dose exposures and diseases, thus avoiding the uncertainty associated with extrapolation across species. In this regard, human epidemiology studies may play a significant role in the new vision of toxicity testing. However, this type of information has not been fully considered in risk assessment, mainly due to the inherent limitations of epidemiologic studies. An integrated approach of in vivo, in vitro and in silico data, together with systematic reviews or meta-analysis of high quality epidemiological studies will improve the robustness of risk assessment of chemical mixtures and will provide a stronger basis for regulatory decisions. The ultimate goal is that experimental and mechanistic data can lend support and biological plausibility to the human epidemiological observations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. The Challenges of Integrating NASA's Human, Budget, and Data Capital within the Constellation Program's Exploration Launch Projects Office

    Science.gov (United States)

    Kidd, Luanne; Morris, Kenneth B.; Self, Timothy A.

    2007-01-01

    The U.S. Vision for Space Exploration directs NASA to retire the Space Shuttle in 2010 and replace it with safe, reliable, and cost-effective space transportation systems for crew and cargo travel to the Moon, Mars, and beyond. Such emerging space transportation initiatives face massive organizational challenges, including building and nurturing an experienced, dedicated team with the right skills for the required tasks; allocating and tracking the fiscal capital invested in achieving technical progress against an integrated master schedule; and turning generated data into useful knowledge that equips the team to design and develop superior products for customers and stakeholders. It has been more than 30 years since the Space Shuttle was designed; therefore, the current aerospace workforce has limited experience with developing new designs for human-rated spaceflight hardware. To accomplish these activities, NASA is using a wide range of state-of-the-art information technology tools that connect its diverse, decentralized teams and provide timely, accurate information for decision makers. In addition, business professionals are assisting technical managers with planning, tracking, and forecasting resource use against an integrated master schedule that horizontally and vertically interlinks hardware elements and milestone events. Furthermore, NASA is employing a wide variety of strategies to ensure that it has the motivated and qualified staff it needs for the tasks ahead. This paper discusses how NASA's Exploration Launch Projects Office, which is responsible for delivering these new launch vehicles, integrates its resources to create an engineering business environment that promotes mission success, which is defined by replacing the Space Shuttle by 2014 and returning to the Moon by 2020.

  9. Implementation challenges for designing integrated in vitro testing strategies (ITS) aiming at reducing and replacing animal experimentation.

    Science.gov (United States)

    De Wever, Bart; Fuchs, Horst W; Gaca, Marianna; Krul, Cyrille; Mikulowski, Stan; Poth, Albrecht; Roggen, Erwin L; Vilà, Maya R

    2012-04-01

    At the IVTIP (in vitro testing industrial platform) meeting of November 26th 2009 entitled 'Toxicology in the 21st century ('21C')--working our way towards a visionary reality' all delegates endorsed the emerging concept of the '21C' vision as the way forward to enable a thorough, reliable and systematic approach to future toxicity testing without the use of animals. One of the emerging concepts focused on integrating a defined number of tests modelling in vivo-relevant and well-characterised toxicity pathways representing mechanistic endpoints. At this meeting the importance of Integrated Testing Strategies (ITS) as tools towards reduction and eventually replacement of the animals currently used for hazard identification and risk assessment was recognised. A follow-up IVTIP Spring 2010 meeting entitled 'Integrated In Vitro Testing Strategies (ITS)--Implementation Challenges' was organised to address pending questions about ITS. This report is not a review of the ITS literature, but a summary of the discussions triggered by presented examples on how to develop and implement ITS. Contrasts between pharmaceutical and chemical industry, as well as a list of general but practical aspects to be considered while developing an ITS emerged from the discussions. In addition, current recommendations on the validation of ITS were discussed. In conclusion, the outcome of this workshop improved the understanding of the participants of some important factors that may impact the design of an ITS in function of its purpose (e.g., screening, or early decision making versus regulatory), the context in which they need to be applied (e.g., ICH guidelines, REACH) and the status and quality of the available tools. A set of recommendations of best practices was established and the importance of the applicability of the individual tests as well as the testing strategy itself was highlighted. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Next-generation transcriptome assembly

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Jeffrey A.; Wang, Zhong

    2011-09-01

    Transcriptomics studies often rely on partial reference transcriptomes that fail to capture the full catalog of transcripts and their variations. Recent advances in sequencing technologies and assembly algorithms have facilitated the reconstruction of the entire transcriptome by deep RNA sequencing (RNA-seq), even without a reference genome. However, transcriptome assembly from billions of RNA-seq reads, which are often very short, poses a significant informatics challenge. This Review summarizes the recent developments in transcriptome assembly approaches - reference-based, de novo and combined strategies-along with some perspectives on transcriptome assembly in the near future.

  11. Using Conventional Hydropower to Help Alleviate Variable Resource Grid Integration Challenges in the Western U.S

    Science.gov (United States)

    Veselka, T. D.; Poch, L.

    2011-12-01

    Integrating high penetration levels of wind and solar energy resources into the power grid is a formidable challenge in virtually all interconnected systems due to the fact that supply and demand must remain in balance at all times. Since large scale electricity storage is currently not economically viable, generation must exactly match electricity demand plus energy losses in the system as time unfolds. Therefore, as generation from variable resources such as wind and solar fluctuate, production from generating resources that are easier to control and dispatch need to compensate for these fluctuations while at the same time respond to both instantaneous change in load and follow daily load profiles. The grid in the Western U.S. is not exempt to grid integration challenges associated with variable resources. However, one advantage that the power system in the Western U.S. has over many other regional power systems is that its footprint contains an abundance of hydropower resources. Hydropower plants, especially those that have reservoir water storage, can physically change electricity production levels very quickly both via a dispatcher and through automatic generation control. Since hydropower response time is typically much faster than other dispatchable resources such as steam or gas turbines, it is well suited to alleviate variable resource grid integration issues. However, despite an abundance of hydropower resources and the current low penetration of variable resources in the Western U.S., problems have already surfaced. This spring in the Pacific Northwest, wetter than normal hydropower conditions in combination with transmission constraints resulted in controversial wind resource shedding. This action was taken since water spilling would have increased dissolved oxygen levels downstream of dams thereby significantly degrading fish habitats. The extent to which hydropower resources will be able to contribute toward a stable and reliable Western grid is

  12. Fuel assembly reconstitution

    International Nuclear Information System (INIS)

    Morgado, Mario M.; Oliveira, Monica G.N.; Ferreira Junior, Decio B.M.; Santos, Barbara O. dos; Santos, Jorge E. dos

    2009-01-01

    Fuel failures have been happened in Nuclear Power Plants worldwide, without lost of integrity and safety, mainly for the public, environment and power plants workers. The most common causes of these events are corrosion (CRUD), fretting and pellet cladding interaction. These failures are identified by increasing the activity of fission products, verified by chemical analyses of reactor coolant. Through these analyses, during the fourth operation cycle of Angra 2 Nuclear Power Plant, was possible to observe fuel failure indication. This indication was confirmed in the end of the cycle during the unloading of reactor core through leakage tests of fuel assembly, using the equipment called 'In Mast Sipping' and 'Box Sipping'. After confirmed, the fuel assembly reconstitution was scheduled, and happened in April, 2007, where was identified the cause and the fuel rod failure, which was substitute by dummy rods (zircaloy). The cause was fretting by 'debris'. The actions to avoid and prevent fuel assemblies failures are important. The goals of this work are to describe the methodology of fuel assembly reconstitution using the FARE (Fuel Assembly Reconstitution Equipment) system, to describe the results of this task in economic and security factors of the company and show how the fuel assembly failures are identified during operation and during the outage. (author)

  13. Integration of In-Flight and Post-Flight Water Monitoring Resources in Addressing the U.S. Water Processor Assembly Total Organic Carbon (TOC) Anomaly

    Science.gov (United States)

    Straub, John E., II; McCly, J. Torin

    2011-01-01

    Beginning in June of 2010, the total organic carbon (TOC) concentration in the U.S. Water Processor Assembly (WPA) product water started to increase. A surprisingly consistent upward TOC trend was observed through weekly ISS total organic carbon analyzer (TOCA) monitoring. As TOC is a general organic compound indicator, return of water archive samples was needed to make better-informed crew health decisions on the specific compounds of concern and to aid in WPA troubleshooting. TOCA-measured TOC was more than halfway to the health-based screening limit of 3,000 g/L before archive samples were returned. Archive samples were returned on 22 Soyuz in September 2010 and on ULF5 in November of 2010. The samples were subjected to extensive analysis. Although TOC was confirmed to be elevated, somewhat surprisingly, none of the typical target compounds were detected at high levels. After some solid detective work, it was confirmed that the TOC was associated with a compound known as dimethylsilanediol (DMSD). DMSD is believed to be a breakdown product of siloxanes which are thought to be ubiquitous in the ISS atmosphere. A toxicological limit was set for DMSD and a forward plan was developed for conducting operations in the context of understanding the composition of the TOC measured in flight. This required careful consideration of existing ISS flight rules, coordination with ISS stakeholders, and development of a novel approach for the blending of inflight TOCA data with archive results to protect crew health. Among other challenges, team members had to determine how to utilize TOCA readings when making decisions about crew consumption of WPA water. This involved balancing very real concerns associated with the assumption that TOC would continue to be comprised of only DMSD. Demonstrated teamwork, multidisciplinary awareness, and innovative problem-solving were required to respond effectively to this anomaly.

  14. Human Assisted Assembly Processes

    Energy Technology Data Exchange (ETDEWEB)

    CALTON,TERRI L.; PETERS,RALPH R.

    2000-01-01

    Automatic assembly sequencing and visualization tools are valuable in determining the best assembly sequences, but without Human Factors and Figure Models (HFFMs) it is difficult to evaluate or visualize human interaction. In industry, accelerating technological advances and shorter market windows have forced companies to turn to an agile manufacturing paradigm. This trend has promoted computerized automation of product design and manufacturing processes, such as automated assembly planning. However, all automated assembly planning software tools assume that the individual components fly into their assembled configuration and generate what appear to be a perfectly valid operations, but in reality the operations cannot physically be carried out by a human. Similarly, human figure modeling algorithms may indicate that assembly operations are not feasible and consequently force design modifications; however, if they had the capability to quickly generate alternative assembly sequences, they might have identified a feasible solution. To solve this problem HFFMs must be integrated with automated assembly planning to allow engineers to verify that assembly operations are possible and to see ways to make the designs even better. Factories will very likely put humans and robots together in cooperative environments to meet the demands for customized products, for purposes including robotic and automated assembly. For robots to work harmoniously within an integrated environment with humans the robots must have cooperative operational skills. For example, in a human only environment, humans may tolerate collisions with one another if they did not cause much pain. This level of tolerance may or may not apply to robot-human environments. Humans expect that robots will be able to operate and navigate in their environments without collisions or interference. The ability to accomplish this is linked to the sensing capabilities available. Current work in the field of cooperative

  15. Integrated cancer therapy combined radiotherapy and immunotherapy. The challenge of using Gc protein-derived macrophage activating factor (GcMAF) as a key molecule

    International Nuclear Information System (INIS)

    Uto, Yoshihiro; Hori, Hitoshi

    2013-01-01

    Radiation oncologists know the conflict between radiotherapy and immunotherapy, but now challenged trails of the integrative cancer therapies combined radiation therapy and various immunoreaction/immune therapies begin. We therefore review the recent results of basic research and clinical trial of the integrated cancer therapies which combined radiotherapy and various immune therapies/immunoreaction, and the challenged studies of combined use of radiotherapy and our developed cancer immunotherapy using serum GcMAF which is human serum containing Gc protein-derived macrophage activating factor (GcMAF). (author)

  16. Technical challenges for electric power industries due to grid-integrated electric vehicles in low voltage distributions: A review

    International Nuclear Information System (INIS)

    Haidar, Ahmed M.A.; Muttaqi, Kashem M.; Sutanto, Danny

    2014-01-01

    Highlights: • Grid-Integrated Vehicles (GIVs) as mobile storage systems are briefly discussed. • Comparative analysis on electric vehicles (EVs) and charging systems are provided. • It is necessary to coordinate the GIVs to minimize its impacts on power grid. • A proper load model of EVs that predicts the realistic system behavior is required. • Offering a dual tariff by grid utilities is needed as a way to reduce peak load. - Abstract: Grid-Integrated Vehicles (GIVs) are promising technologies for future Smart Grid (SG) and offer the potential to reduce the environmental impact of vehicles. The large scale deployment of GIVs without proper control of the time to charge the vehicles can result in unexpected challenges. This can lead to a disruptive impact on the current power distribution systems and in particular its substantial impacts in building power energy systems. Therefore, a proper model that predicts the realistic system behavior is required to analysis the true effects of introducing GIVs in the power grid. This paper presents a review of existing studies on GIV systems, their modeling techniques and their effects on power grids. Following a brief overview of the common types of electric vehicles (EVs) with their charging systems, a review of their impact on the low voltage distribution systems will be analyzed. The comprehensive review presented in this paper reveals that the impact of GIVs on power distribution systems can be quantified using the aspects of EVs, such as vehicle penetration, charging time, charging characteristics, driving patterns, transportation network. GIV studies are expected to be more popular in future years with the development of EV technologies and the government support to electricity utilities. Thereby, these factors will reduce the cost of energy to charge EV and enhance the practical implications of GIVs

  17. The Evolution of Integrated Assessment and Emerging Challenges in the Assessment of Human and Natural System Interactions

    Science.gov (United States)

    Clarke, L.

    2017-12-01

    Integrated assessment (IA) modeling and research has a long history, spanning over 30 years since its inception and addressing a wide range of contemporary issues along the way. Over the last decade, IA modeling and research has emerged as one of the primary analytical methods for understanding the complex interactions between human and natural systems, from the interactions between energy, water, and land/food systems to the interplay between health, climate, and air pollution. IA modeling and research is particularly well-suited for the analysis of these interactions because it is a discipline that strives to integrate representations of multiple systems into consistent computational platforms or frameworks. In doing so, it explicitly confronts the many tradeoffs that are frequently necessary to manage complexity and computational cost while still representing the most important interactions and overall, coupled system behavior. This talk explores the history of IA modeling and research as a means to better understand its role in the assessment of contemporary issues at the confluence of human and natural systems. It traces the evolution of IA modeling and research from initial exploration of long-term emissions pathways, to the role of technology in the global evolution of the energy system, to the key linkages between land and energy systems and, more recently, the linkages with water, air pollution, and other key systems and issues. It discusses the advances in modeling that have emerged over this evolution and the biggest challenges that still present themselves as we strive to better understand the most important interactions between human and natural systems and the implications of these interactions for human welfare and decision making.

  18. Engineering challenges of BioNEMS: the integration of microfluidics, micro- and nanodevices, models and external control for systems biology.

    Science.gov (United States)

    Wikswo, J P; Prokop, A; Baudenbacher, F; Cliffel, D; Csukas, B; Velkovsky, M

    2006-08-01

    Systems biology, i.e. quantitative, postgenomic, postproteomic, dynamic, multiscale physiology, addresses in an integrative, quantitative manner the shockwave of genetic and proteomic information using computer models that may eventually have 10(6) dynamic variables with non-linear interactions. Historically, single biological measurements are made over minutes, suggesting the challenge of specifying 10(6) model parameters. Except for fluorescence and micro-electrode recordings, most cellular measurements have inadequate bandwidth to discern the time course of critical intracellular biochemical events. Micro-array expression profiles of thousands of genes cannot determine quantitative dynamic cellular signalling and metabolic variables. Major gaps must be bridged between the computational vision and experimental reality. The analysis of cellular signalling dynamics and control requires, first, micro- and nano-instruments that measure simultaneously multiple extracellular and intracellular variables with sufficient bandwidth; secondly, the ability to open existing internal control and signalling loops; thirdly, external BioMEMS micro-actuators that provide high bandwidth feedback and externally addressable intracellular nano-actuators; and, fourthly, real-time, closed-loop, single-cell control algorithms. The unravelling of the nested and coupled nature of cellular control loops requires simultaneous recording of multiple single-cell signatures. Externally controlled nano-actuators, needed to effect changes in the biochemical, mechanical and electrical environment both outside and inside the cell, will provide a major impetus for nanoscience.

  19. Phase Preference by Active, Acetate-Utilizing Bacteria at the Rifle, CO Integrated Field Research Challenge Site

    Energy Technology Data Exchange (ETDEWEB)

    Kerkhof, L.; Williams, K.H.; Long, P.E.; McGuinness, L.

    2011-02-21

    Previous experiments at the Rifle, Colorado Integrated Field Research Challenge (IFRC) site demonstrated that field-scale addition of acetate to groundwater reduced the ambient soluble uranium concentration. In this report, sediment samples collected before and after acetate field addition were used to assess the active microbes via {sup 13}C acetate stable isotope probing on 3 phases [coarse sand, fines (8-approximately 150 {micro}m), groundwater (0.2-8 {micro}m)] over a 24-day time frame. TRFLP results generally indicated a stronger signal in {sup 13}C-DNA in the 'fines' fraction compared to the sand and groundwater. Before the field-scale acetate addition, a Geobacter-like group primarily synthesized {sup 13}C-DNA in the groundwater phase, an alpha Proteobacterium primarily grew on the fines/sands, and an Acinetobacter sp. and Decholoromonas-like OTU utilized much of the {sup 13}C acetate in both groundwater and particle-associated phases. At the termination of the field-scale acetate addition, the Geobacter-like species was active on the solid phases rather than the groundwater, while the other bacterial groups had very reduced newly synthesized DNA signal. These findings will help to delineate the acetate utilization patterns of bacteria in the field and can lead to improved methods for stimulating distinct microbial populations in situ.

  20. Liaison based assembly design

    Energy Technology Data Exchange (ETDEWEB)

    Ames, A.; Kholwadwala, D.; Wilson, R.H.

    1996-12-01

    Liaison Based Assembly Design extends the current information infrastructure to support design in terms of kinematic relationships between parts, or liaisons. These liaisons capture information regarding contact, degrees-of-freedom constraints and containment relationships between parts in an assembly. The project involved defining a useful collection of liaison representations, investigating their properties, and providing for maximum use of the data in downstream applications. We tested our ideas by implementing a prototype system involving extensions to Pro/Engineer and the Archimedes assembly planner. With an expanded product model, the design system is more able to capture design intent. When a product update is attempted, increased knowledge availability improves our ability to understand the effect of design changes. Manufacturing and analysis disciplines benefit from having liaison information available, so less time is wasted arguing over incomplete design specifications and our enterprise can be more completely integrated.

  1. From self-organization to self-assembly: a new materialism?

    Science.gov (United States)

    Vincent, Bernadette Bensaude

    2016-09-01

    While self-organization has been an integral part of academic discussions about the distinctive features of living organisms, at least since Immanuel Kant's Critique of Judgement, the term 'self-assembly' has only been used for a few decades as it became a hot research topic with the emergence of nanotechnology. Could it be considered as an attempt at reducing vital organization to a sort of assembly line of molecules? Considering the context of research on self-assembly I argue that the shift of attention from self-organization to self-assembly does not really challenge the boundary between chemistry and biology. Self-assembly was first and foremost investigated in an engineering context as a strategy for manufacturing without human intervention and did not raise new perspectives on the emergence of vital organization itself. However self-assembly implies metaphysical assumptions that this paper tries to disentangle. It first describes the emergence of self-assembly as a research field in the context of materials science and nanotechnology. The second section outlines the metaphysical implications and will emphasize a sharp contrast between the ontology underlying two practices of self-assembly developed under the umbrella of synthetic biology. And unexpectedly, we shall see that chemists are less on the reductionist side than most synthetic biologists. Finally, the third section ventures some reflections on the kind of design involved in self-assembly practices.

  2. Rehabilitation-specific challenges and advantages in the integration of migrant physicians in Germany: a multiperspective qualitative interview study in rehabilitative settings.

    Science.gov (United States)

    Jansen, E; Hänel, P; Klingler, C

    2018-07-01

    In Germany, rehabilitative healthcare institutions increasingly rely on migrant physicians to meet their staffing needs. Yet until now, research on the integration of migrant physicians has focussed entirely on the acute care setting. This study is the first to address the specific advantages and challenges to integration in the field of rehabilitative medicine where a high number of migrant physicians work. From the experiences of migrant physicians and their colleagues, we provide actionable suggestions to counteract potential sources of conflict and thereby improve the integration of migrant physicians in the German workforce. We conducted a qualitative interview study. We conducted 23 interviews with a total of 26 participants occupying a variety of roles in two different rehabilitation centres (maximum variation sampling). Interviews were recorded, transcribed verbatim and parsed through thematic analysis. Our research revealed advantages and challenges to integration in three distinct areas: rehabilitative care institutions, competencies of migrant professionals and interpersonal relations. The first set of issues hinges on the work processes within rehabilitative hospitals, professional prospects there and the location of the institutions themselves. Second, migrant physicians may encounter difficulties because of limited linguistic skills and country-specific knowledge. And finally, aspects of their interactions with care teams and patients may constitute barriers to integration. Some of the factors influencing the integration of migrant physicians are the same in both rehabilitative and acute medicine, but the rehabilitative setting presents distinct advantages and challenges that are worthy of study in their own right. We outline several measures which could help overcome challenges to the integration of migrant physicians, including those associated with professional relationships. Further research is needed to develop concrete support programmes

  3. Fuel assembly

    International Nuclear Information System (INIS)

    Abe, Hideaki; Sakai, Takao; Ishida, Tomio; Yokota, Norikatsu.

    1992-01-01

    The lower ends of a plurality of plate-like shape memory alloys are secured at the periphery of the upper inside of the handling head of a fuel assembly. As the shape memory alloy, a Cu-Zn alloy, a Ti-Pd alloy or a Fe-Ni alloy is used. When high temperature coolants flow out to the handling head, the shape memory alloy deforms by warping to the outer side more greatly toward the upper portion thereof with the temperature increase of the coolants. As the result, the shape of the flow channel of the coolants is changed so as to enlarge at the exit of the upper end of the fuel assembly. Then, the pressure loss of the coolants in the fuel assembly is decreased by the enlargement. Accordingly, the flow rate of the coolants in the fuel assembly is increased to lower the temperature of the coolants. Further, high temperature coolants and low temperature coolants are mixed sufficiently just above the fuel assembly. This can suppress the temperature fluctuation of the mixed coolants in the upper portion of the reactor core, thereby enabling to decrease a fatigue and failures of the structural components in the upper portion of the reactor core. (I.N.)

  4. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  5. Impact analysis of spent fuel jacket assemblies

    International Nuclear Information System (INIS)

    Aramayo, G.A.

    1994-01-01

    As part of the analyses performed in support of the reracking of the High Flux Isotope Reactor pool, it became necessary to prove the structural integrity of the spent fuel jacket assemblies subjected to gravity drop that result from postulated accidents associated with the handling of these assemblies while submerged in the pool. The spent fuel jacket assemblies are an integral part of the reracking project, and serve to house fuel assemblies. The structure integrity of the jacket assemblies from loads that result from impact from a height of 10 feet onto specified targets has been performed analytically using the computer program LS-DYNA3D. Nine attitudes of the assembly at the time of impact have been considered. Results of the analyses show that there is no failure of the assemblies as a result of the impact scenarios considered

  6. Fuel assembly

    International Nuclear Information System (INIS)

    Nakatsuka, Masafumi; Matsuzuka, Ryuji.

    1976-01-01

    Object: To provide a fuel assembly which can decrease pressure loss of coolant to uniform temperature. Structure: A sectional area of a flow passage in the vicinity of an inner peripheral surface of a wrapper tube is limited over the entire length to prevent the temperature of a fuel element in the outermost peripheral portion from being excessively decreased to thereby flatten temperature distribution. To this end, a plurality of pincture-frame-like sheet metals constituting a spacer for supporting a fuel assembly, which has a plurality of fuel elements planted lengthwise and in given spaced relation within the wrapper tube, is disposed in longitudinal grooves and in stacked fashion to form a substantially honeycomb-like space in cross section. The fuel elements are inserted and supported in the space to form a fuel assembly. (Kamimura, M.)

  7. Fuel assemblies

    International Nuclear Information System (INIS)

    Nagano, Mamoru; Yoshioka, Ritsuo

    1983-01-01

    Purpose: To effectively utilize nuclear fuels by increasing the reactivity of a fuel assembly and reduce the concentration at the central region thereof upon completion of the burning. Constitution: A fuel assembly is bisected into a central region and a peripheral region by disposing an inner channel box within a channel box. The flow rate of coolants passing through the central region is made greater than that in the peripheral region. The concentration of uranium 235 of the fuel rods in the central region is made higher. In such a structure, since the moderating effect in the central region is improved, the reactivity of the fuel assembly is increased and the uranium concentration in the central region upon completion of the burning can be reduced, fuel economy and effective utilization of uranium can be attained. (Kamimura, M.)

  8. On the Path to SunShot. Emerging Issues and Challenges in Integrating Solar with the Distribution System

    Energy Technology Data Exchange (ETDEWEB)

    Palmintier, Bryan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Broderick, Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mather, Barry [National Renewable Energy Lab. (NREL), Golden, CO (United States); Coddington, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baker, Kyri [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ding, Fei [National Renewable Energy Lab. (NREL), Golden, CO (United States); Reno, Matthew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lave, Matthew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bharatkumar, Ashwini [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2016-05-01

    This report analyzes distribution-integration challenges, solutions, and research needs in the context of distributed generation from PV (DGPV) deployment to date and the much higher levels of deployment expected with achievement of the U.S. Department of Energy's SunShot targets. Recent analyses have improved estimates of the DGPV hosting capacities of distribution systems. This report uses these results to statistically estimate the minimum DGPV hosting capacity for the contiguous United States using traditional inverters of approximately 170 GW without distribution system modifications. This hosting capacity roughly doubles if advanced inverters are used to manage local voltage and additional minor, low-cost changes could further increase these levels substantially. Key to achieving these deployment levels at minimum cost is siting DGPV based on local hosting capacities, suggesting opportunities for regulatory, incentive, and interconnection innovation. Already, pre-computed hosting capacity is beginning to expedite DGPV interconnection requests and installations in select regions; however, realizing SunShot-scale deployment will require further improvements to DGPV interconnection processes, standards and codes, and compensation mechanisms so they embrace the contributions of DGPV to system-wide operations. SunShot-scale DGPV deployment will also require unprecedented coordination of the distribution and transmission systems. This includes harnessing DGPV's ability to relieve congestion and reduce system losses by generating closer to loads; minimizing system operating costs and reserve deployments through improved DGPV visibility; developing communication and control architectures that incorporate DGPV into system operations; providing frequency response, transient stability, and synthesized inertia with DGPV in the event of large-scale system disturbances; and potentially managing reactive power requirements due to large-scale deployment of advanced

  9. Phase Preference by Active, Acetate-Utilizing Bacteria at the Rifle, CO Integrated Field Research Challenge Site

    International Nuclear Information System (INIS)

    Kerkhoff, Lee; Williams, Kenneth H.; Long, Philip E.; McGuinness, L.

    2011-01-01

    Uranium contaminated groundwaters are a legacy concern for the U.S. Department of Energy. Previous experiments at the Rifle, Colorado Integrated Field Challenge (IFC) site have demonstrated that field-scale addition of acetate to groundwater reduces the ambient soluable uranium concentration, sequestering the radionuclide as uraninite. However, questions remain regarding which microorganism(s) are consuming this acetate and if active groundwater microorganisms are different from active particle-associated bacteria. In this report, 13-C acetate was used to assess the active microbes that synthesize DNA on 3 size fractions (coarse sand, fines (8-approximately 150 micron), groundwater (0.2-8 micron)) over a 24 -day time frame. Results indicated a stronger signal from 13-C acetate associated with the 'fines' fraction compared with smaller amounts of 13-C uptake on the sand fraction and groundwater samples during the SIP incubations. TRFLP analysis of this 13-C-labeled DNA, indicated 31+ 9 OTU's with 6 peaks dominating the active profiles (166, 187, 210, 212, and 277 bp peaks using MnlI). Cloning/sequencing of the amplification products indicated a Geobacter-like group (187, 210, 212 bp) primarily synthesized DNA from acetate in the groundwater phase, an alpha Proteobacterium (166 bp) primarily grew on the fines/sands, and an Acinetobacter sp. (277 bp) utilized much of the 13C acetate in both groundwater and particle-associated phases. These findings will help to delineate the acetate utilization patterns of bacteria during field-scale acetate addition and can lead to improved methods for stimulating distinct microbial populations in situ.

  10. Postural Stability of Patients with Schizophrenia during Challenging Sensory Conditions: Implication of Sensory Integration for Postural Control.

    Directory of Open Access Journals (Sweden)

    Ya-Ling Teng

    Full Text Available Postural dysfunctions are prevalent in patients with schizophrenia and affect their daily life and ability to work. In addition, sensory functions and sensory integration that are crucial for postural control are also compromised. This study intended to examine how patients with schizophrenia coordinate multiple sensory systems to maintain postural stability in dynamic sensory conditions. Twenty-nine patients with schizophrenia and 32 control subjects were recruited. Postural stability of the participants was examined in six sensory conditions of different level of congruency of multiple sensory information, which was based on combinations of correct, removed, or conflicting sensory inputs from visual, somatosensory, and vestibular systems. The excursion of the center of pressure was measured by posturography. Equilibrium scores were derived to indicate the range of anterior-posterior (AP postural sway, and sensory ratios were calculated to explore ability to use sensory information to maintain balance. The overall AP postural sway was significantly larger for patients with schizophrenia compared to the controls [patients (69.62±8.99; controls (76.53±7.47; t1,59 = -3.28, p<0.001]. The results of mixed-model ANOVAs showed a significant interaction between the group and sensory conditions [F5,295 = 5.55, p<0.001]. Further analysis indicated that AP postural sway was significantly larger for patients compared to the controls in conditions containing unreliable somatosensory information either with visual deprivation or with conflicting visual information. Sensory ratios were not significantly different between groups, although small and non-significant difference in inefficiency to utilize vestibular information was also noted. No significant correlations were found between postural stability and clinical characteristics. To sum up, patients with schizophrenia showed increased postural sway and a higher rate of falls during challenging sensory

  11. Challenges and Solutions for the Integration of Structural and Hydrogeological Understanding of Fracture Systems - Insights from the Olkiluoto Site, Finland

    Science.gov (United States)

    Hartley, L. J.; Aaltonen, I.; Baxter, S. J.; Cottrell, M.; Fox, A. L.; Hoek, J.; Koskinen, L.; Mattila, J.; Mosley, K.; Selroos, J. O.; Suikkanen, J.; Vanhanarkaus, O.; Williams, T. R. N.

    2017-12-01

    A field site at Olkiluoto in SW Finland has undergone extensive investigations as a location for a deep geological repository for spent nuclear fuel, which is expected to become operational in the early 2020s. Characterisation data comes from 58 deep cored drillholes, a wide variety of geophysical investigations, many outcrops, kilometres of underground mapping and testing in the ONKALO research facility, and groundwater pressure monitoring and sampling in both deep and shallow holes. A primary focus is on the properties of natural fractures and brittle fault zones in the low permeability crystalline rocks at Olkiluoto; an understanding of the flow and transport processes in these features are an essential part of assessing long-term safety of the repository. This presentation will illustrate how different types of source data and cross-disciplinary interpretations are integrated to develop conceptual and numerical models of the fracture system. A model of the brittle fault zones developed from geological and geophysical data provides the hydrostructural backbone controlling the most intense fracturing and dynamic conduits for fluids. Models of ductile deformation and lithology form a tectonic framework for the description of fracture heterogeneity in the background rock, revealing correlations between the intensity and orientation of fractures with geological and spatial properties. The sizes of brittle features are found to be best defined on two scales relating to individual fractures and zones. Inferred fracture-specific from flow logging are correlated with fracture geometric and mechanical properties along with in situ stress measurements to create a hydromechanical description of fracture hydraulic properties. The insights and understandings gained from these efforts help define a discrete fracture network (DFN) model for the Olkiluoto site, with hydrogeological characteristics consistent with monitoring data of hydraulic heads and their disturbances to

  12. [Integrity].

    Science.gov (United States)

    Gómez Rodríguez, Rafael Ángel

    2014-01-01

    To say that someone possesses integrity is to claim that that person is almost predictable about responses to specific situations, that he or she can prudentially judge and to act correctly. There is a closed interrelationship between integrity and autonomy, and the autonomy rests on the deeper moral claim of all humans to integrity of the person. Integrity has two senses of significance for medical ethic: one sense refers to the integrity of the person in the bodily, psychosocial and intellectual elements; and in the second sense, the integrity is the virtue. Another facet of integrity of the person is la integrity of values we cherish and espouse. The physician must be a person of integrity if the integrity of the patient is to be safeguarded. The autonomy has reduced the violations in the past, but the character and virtues of the physician are the ultimate safeguard of autonomy of patient. A field very important in medicine is the scientific research. It is the character of the investigator that determines the moral quality of research. The problem arises when legitimate self-interests are replaced by selfish, particularly when human subjects are involved. The final safeguard of moral quality of research is the character and conscience of the investigator. Teaching must be relevant in the scientific field, but the most effective way to teach virtue ethics is through the example of the a respected scientist.

  13. Valve assembly

    International Nuclear Information System (INIS)

    Sandling, M.

    1981-01-01

    An improved valve assembly, used for controlling the flow of radioactive slurry, is described. Radioactive contamination of the air during removal or replacement of the valve is prevented by sucking air from the atmosphere through a portion of the structure above the valve housing. (U.K.)

  14. Fuel assembly

    International Nuclear Information System (INIS)

    Gjertsen, R.K.; Bassler, E.A.; Huckestein, E.A.; Salton, R.B.; Tower, S.N.

    1988-01-01

    A fuel assembly adapted for use with a pressurized water nuclear reactor having capabilities for fluid moderator spectral shift control is described comprising: parallel arranged elongated nuclear fuel elements; means for providing for axial support of the fuel elements and for arranging the fuel elements in a spaced array; thimbles interspersed among the fuel elements adapted for insertion of a rod control cluster therewithin; means for structurally joining the fuel elements and the guide thimbles; fluid moderator control means for providing a volume of low neutron absorbing fluid within the fuel assembly and for removing a substantially equivalent volume of reactor coolant water therefrom, a first flow manifold at one end of the fuel assembly sealingly connected to a first end of the moderator control tubes whereby the first ends are commonly flow connected; and a second flow manifold, having an inlet passage and an outlet passage therein, sealingly connected to a second end of the moderator control tubes at a second end of the fuel assembly

  15. Dealing with the challenge of building a Biochemistry Program in an integrated Medical curriculum. The need for new didactics, new focal interests, and new connections to other disciplines

    Directory of Open Access Journals (Sweden)

    Miguel A. R. B. Castanho

    2017-07-01

    Full Text Available Teaching in Health Sciences is rapidly evolving. Medical schools, for instance, are increasingly opting for integrated curricula. Biochemistry no longer is considered a discipline by itself; instead, Biochemistry is a part of a wider universe of knowledge integrated in modulus. These modulus often relate to physiological human body systems or the concept of Organic and Functional Systems. In either case, the bridging between Biochemistry, Histology, Anatomy, Physiology, and Pharmacology is largely explored. This bridging is a challenge in Biochemistry teaching. A second challenge adds to this: the way new generations of students perceive communication is much different than the way knowledge is communicated in classrooms. Modern forms of information exchange are multimedia, fast and interactive; lectures are traditionally descriptive, use classical expositive didactics and highlight detailed disciplinary matters. How to cope with the new challenges in the Biochemistry classroom will be addressed. A new biochemistry textbook, totally conceived for a Biochemistry Program in an integrated curriculum in health sciences at present will be taken as example. The choice of core contents, illustrative examples and the approach to teaching were carefully addressed in light of the new challenges identified above.

  16. The Challenge of Integrating OHS into Industrial Project Risk Management: Proposal of a Methodological Approach to Guide Future Research (Case of Mining Projects in Quebec, Canada

    Directory of Open Access Journals (Sweden)

    Adel Badri

    2015-06-01

    Full Text Available Although risk management tools are put to good use in many industrial sectors, some large projects have been met with numerous problems due to failure to take occupational health and safety (OHS into consideration. In spite of the high level of risk and uncertainty associated with many industrial projects, the number of studies of methods for managing all known risks systematically remains small. Under effervescent economic conditions, industries must meet several challenges associated with frequent project start-ups. In highly complex and uncertain environments, rigorous management of risk remains indispensable for avoiding threats to the success of projects. Many businesses seek continually to create and improve integrated approaches to risk management. This article puts into perspective the complexity of the challenge of integrating OHS into industrial project risk management. A conceptual and methodological approach is proposed to guide future research focused on meeting this challenge. The approach is based on applying multi-disciplinary research modes to a complex industrial context in order to identify all scenarios likely to contain threats to humans or the environment. A case study is used to illustrate the potential of the proposed approach for application and its contribution to meeting the challenge of taking OHS into consideration. On-site researchers were able to develop a new approach that helped two mining companies in Quebec (Canada to achieve successful integration of OHS into expansion projects.

  17. Fuel assembly

    International Nuclear Information System (INIS)

    Yokota, Tokunobu.

    1990-01-01

    A fuel assembly used in a FBR type nuclear reactor comprises a plurality of fuel rods and a moderator guide member (water rod). A moderator exit opening/closing mechanism is formed at the upper portion of the moderator guide member for opening and closing a moderator exit. In the initial fuel charging operation cycle to the reactor, the moderator exit is closed by the moderator exit opening/closing mechanism. Then, voids are accumulated at the inner upper portion of the moderator guide member to harden spectrum and a great amount of plutonium is generated and accumulated in the fuel assembly. Further, in the fuel re-charging operation cycle, the moderator guide member is used having the moderator exit opened. In this case, voids are discharged from the moderator guide member to decrease the ratio, and the plutonium accumulated in the initial charging operation cycle is burnt. In this way, the fuel economy can be improved. (I.N.)

  18. Fuel assemblies

    International Nuclear Information System (INIS)

    Echigoya, Hironori; Nomata, Terumitsu.

    1983-01-01

    Purpose: To render the axial distribution relatively flat. Constitution: First nuclear element comprises a fuel can made of zircalloy i.e., the metal with less neutron absorption, which is filled with a plurality of UO 2 pellets and sealed by using a lower end plug, a plenum spring and an upper end plug by means of welding. Second fuel element is formed by substituting a part of the UO 2 pellets with a water tube which is sealed with water and has a space for allowing the heat expansion. The nuclear fuel assembly is constituted by using the first and second fuel elements together. In such a structure, since water reflects neutrons and decrease their leakage to increase the temperature, reactivity is added at the upper portion of the fuel assembly to thereby flatten the axial power distribution. Accordingly, stable operation is possible only by means of deep control rods while requiring no shallow control rods. (Sekiya, K.)

  19. Fuel assembly

    International Nuclear Information System (INIS)

    Kawai, Mitsuo.

    1988-01-01

    Purpose: To reduce the corrosion rate and suppress the increase of radioactive corrosion products in reactor water of nuclear fuel assemblies for use in BWR type reactors having spacer springs made of nickel based deposition reinforced type alloys. Constitution: Spacer rings made of nickel based deposition reinforced type alloy are incorporated and used as fuel assemblies after applying treatment of dipping and maintaining at high temperature water followed by heating in steams. Since this can remove the nickel leaching into reactor water at the initial stage, Co-58 as the radioactive corrosion products in the reactor water can be reduced, and the operation at in-service inspection or repairement can be facilitated to improve the working efficiency of the nuclear power plant. The dipping time is desirably more than 10 hours and more desirably more than 30 hours. (Horiuchi, T. )

  20. Fuel assembly

    International Nuclear Information System (INIS)

    Watanabe, Shoichi; Hirano, Yasushi.

    1998-01-01

    A one-half or more of entire fuel rods in a fuel assembly comprises MOX fuel rods containing less than 1wt% of burnable poisons, and at least a portion of the burnable poisons comprises gadolinium. Then, surplus reactivity at an initial stage of operation cycle is controlled to eliminate burnable poisons remained unburnt at a final stage, as well as increase thermal reactivity. In addition, the content of fission plutonium is determined to greater than the content of uranium 235, and fuel rods at corner portions are made not to incorporate burnable poisons. Fuel rods not containing burnable poisons are disposed at positions in adjacent with fuel rods facing to a water rod at one or two directions. Local power at radial center of the fuel assembly is increased to flatten the distortion of radial power distribution. (N.H.)

  1. The Challenges of Promoting Literacy Integration within a Play-Based Learning Kindergarten Program: Teacher Perspectives and Implementation

    Science.gov (United States)

    Pyle, Angela; Poliszczuk, Daniel; Danniels, Erica

    2018-01-01

    Kindergarten teachers face the challenge of balancing traditional developmental programming and contemporary academic standards. In classrooms following a play-based learning framework, academic content such as literacy is to be taught within children's play. However, educators have reported conceptual and practical challenges with integrating…

  2. General Assembly

    CERN Multimedia

    Staff Association

    2016-01-01

    5th April, 2016 – Ordinary General Assembly of the Staff Association! In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Tuesday, April 5th 2016 from 11:00 to 12:00 in BE Auditorium, Meyrin (6-2-024). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its financial management, and an opportunity to express one’s opinion, including taking part in the votes. Other points are listed on the agenda, as proposed by the Staff Council. Who can vote? Only “ordinary” members (MPE) of the SA can vote. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give his/her opinion? The Ordinary General Asse...

  3. Fuel assembly

    International Nuclear Information System (INIS)

    Ueda, Sei; Ando, Ryohei; Mitsutake, Toru.

    1995-01-01

    The present invention concerns a fuel assembly suitable to a BWR-type reactor and improved especially with the nuclear characteristic, heat performance, hydraulic performance, dismantling or assembling performance and economical property. A part of poison rods are formed as a large-diameter/multi-region poison rods having a larger diameter than a fuel rod. A large number of fuel rods are disposed surrounding a large diameter water rod and a group of the large-diameter/multi-region poison rods in adjacent with the water rod. The large-diameter water rod has a burnable poison at the tube wall portion. At least a portion of the large-diameter poison rods has a coolant circulation portion allowing coolants to circulate therethrough. Since the large-diameter poison rods are disposed at a position of high neutron fluxes, a large neutron multiplication factor suppression effect can be provided, thereby enabling to reduce the number of burnable poison rods relative to fuels. As a result, power peaking in the fuel assembly is moderated and a greater amount of plutonium can be loaded. In addition the flow of cooling water which tends to gather around the large diameter water rod can be controlled to improve cooling performance of fuels. (N.H.)

  4. Administrative Challenges to the Integration of Oral Health With Primary Care: A SWOT Analysis of Health Care Executives at Federally Qualified Health Centers.

    Science.gov (United States)

    Norwood, Connor W; Maxey, Hannah L; Randolph, Courtney; Gano, Laura; Kochhar, Komal

    Inadequate access to preventive oral health services contributes to oral health disparities and is a major public health concern in the United States. Federally Qualified Health Centers play a critical role in improving access to care for populations affected by oral health disparities but face a number of administrative challenges associated with implementation of oral health integration models. We conducted a SWOT (strengths, weaknesses, opportunities, and threats) analysis with health care executives to identify strengths, weaknesses, opportunities, and threats of successful oral health integration in Federally Qualified Health Centers. Four themes were identified: (1) culture of health care organizations; (2) operations and administration; (3) finance; and (4) workforce.

  5. Probing integration strength of colloidal spheres self-assembled from TiO2 nanocrystals by in-situ TEM indentation

    NARCIS (Netherlands)

    Chen, C.Q.; Pei, Y.T.; De Hosson, J.Th.M.; Luysberg, M.; Tillmann, K.; Weirich, T.

    2008-01-01

    Small building blocks such as molecules and nanoparticles, with controlled size, shape, and properties, have been recently utilized as artificial building blocks to assemble two- or three-dimensional structures via “bottom up” processes. Unlike the well known ionic, metallic, or covalent bonds

  6. Introducing perennial biomass crops into agricultural landscapes to address water quality challenges and provide other environmental services: Integrating perennial bioenergy crops into agricultural landscapes

    Energy Technology Data Exchange (ETDEWEB)

    Cacho, J. F. [Environmental Science Division, Argonne National Laboratory, Lemont IL USA; Negri, M. C. [Environmental Science Division, Argonne National Laboratory, Lemont IL USA; Zumpf, C. R. [Environmental Science Division, Argonne National Laboratory, Lemont IL USA; Campbell, P. [Environmental Science Division, Argonne National Laboratory, Lemont IL USA

    2017-11-29

    The world is faced with a difficult multiple challenge of meeting nutritional, energy, and other basic needs, under a limited land and water budget, of between 9 and 10 billion people in the next three decades, mitigating impacts of climate change, and making agricultural production resilient. More productivity is expected from agricultural lands, but intensification of production could further impact the integrity of our finite surface water and groundwater resources. Integrating perennial bioenergy crops in agricultural lands could provide biomass for biofuel and potential improvements on the sustainability of commodity crop production. This article provides an overview of ways in which research has shown that perennial bioenergy grasses and short rotation woody crops can be incorporated into agricultural production systems with reduced indirect land use change, while increasing water quality benefits. Current challenges and opportunities as well as future directions are also highlighted.

  7. Storage method for spent fuel assembly

    International Nuclear Information System (INIS)

    Tajiri, Hiroshi.

    1992-01-01

    In the present invention, spent fuel assemblies are arranged at a dense pitch in a storage rack by suppressing the reactivity of the assemblies, to increase storage capacity for the spent fuel assemblies. That is, neutron absorbers are filled in the cladding tube of an absorbing rod, and the diameter thereof is substantially equal with that of a fuel rod. A great amount of the absorbing rods are arranged at the outer circumference of the fuel assembly. Then, they are fixed integrally to the fuel assembly and stored in a storage rack. In this case, the storage rack may be constituted only with angle materials which are inexpensive and installed simply. With such a constitution, in the fuel assembly having absorbing rods wound therearound, neutrons are absorbed by absorbing rods and the reactivity is lowered. Accordingly, the assembly arrangement pitch in the storage rack can be made dense. As a result, the storage capacity for the assemblies is increased. (I.S.)

  8. SCT Barrel Assembly Complete

    CERN Multimedia

    L. Batchelor

    As reported in the April 2005 issue of the ATLAS eNews, the first of the four Semiconductor Tracker (SCT) barrels, complete with modules and services, arrived safely at CERN in January of 2005. In the months since January, the other three completed barrels arrived as well, and integration of the four barrels into the entire barrel assembly commenced at CERN, in the SR1 building on the ATLAS experimental site, in July. Assembly was completed on schedule in September, with the addition of the innermost layer to the 4-barrel assembly. Work is now underway to seal the barrel thermal enclosure. This is necessary in order to enclose the silicon tracker in a nitrogen atmosphere and provide it with faraday-cage protection, and is a delicate and complicated task: 352 silicon module powertapes, 352 readout-fibre bundles, and over 400 Detector Control System sensors must be carefully sealed into the thermal enclosure bulkhead. The team is currently verifying the integrity of the low mass cooling system, which must be d...

  9. Baseline integrated behavioural and biological assessment among most at-risk populations in six high-prevalence states of India: design and implementation challenges.

    Science.gov (United States)

    Saidel, Tobi; Adhikary, Rajatashuvra; Mainkar, Mandar; Dale, Jayesh; Loo, Virginia; Rahman, Motiur; Ramesh, Banadakoppa M; Paranjape, Ramesh S

    2008-12-01

    This paper presents key methodological approaches and challenges in implementing and analysing the first round of the integrated biobehavioural assessment of most-at-risk populations, conducted in conjunction with evaluation of Avahan, the India AIDS initiative. The survey collected data on HIV risk behaviours, sexually transmitted infections and HIV prevalence in 29 districts in six high-prevalence states of India. Groups included female sex workers and clients, men who have sex with men, injecting drug users and truck drivers. Strategies for overcoming some challenges of the large-scale surveys among vulnerable populations, including sampling hidden populations, involvement of the communities targeted by the survey, laboratory and quality control in remote, non-clinic field settings, and data analysis and data use are presented. Satisfying the need for protocols, guidelines and tools that allowed for sufficient standardization, while being tailored enough to fit diverse local situations on such a large scale, with so many implementing partners, emerged as a major management challenge. A major lesson from the first round is the vital importance of investing upfront time in tailoring the sampling methods, data collection instruments, and analysis plan to match measurement objectives. Despite the challenges, the integrated biobehavioural assessment was a huge achievement, and was largely successful in providing previously unavailable information about the HIV situation among populations that are critical to the curtailment of HIV spread in India. Lessons from the first round will be used to evolve the second round into an exercise with increased evaluative capability for Avahan.

  10. Fuel assembly

    International Nuclear Information System (INIS)

    Fujibayashi, Toru.

    1970-01-01

    Herein disclosed is a fuel assembly in which a fuel rod bundle is easily detachable by rotating a fuel rod fastener rotatably mounted to the upper surface of an upper tie-plate supporting a fuel bundle therebelow. A locking portion at the leading end of each fuel rod protrudes through the upper tie-plate and is engaged with or separated from the tie-plate by the rotation of the fastener. The removal of a desired fuel rod can therefore be remotely accomplished without the necessity of handling pawls, locking washers and nuts. (Owens, K.J.)

  11. Assembling consumption

    DEFF Research Database (Denmark)

    Assembling Consumption marks a definitive step in the institutionalisation of qualitative business research. By gathering leading scholars and educators who study markets, marketing and consumption through the lenses of philosophy, sociology and anthropology, this book clarifies and applies...... the investigative tools offered by assemblage theory, actor-network theory and non-representational theory. Clear theoretical explanation and methodological innovation, alongside empirical applications of these emerging frameworks will offer readers new and refreshing perspectives on consumer culture and market...... societies. This is an essential reading for both seasoned scholars and advanced students of markets, economies and social forms of consumption....

  12. Fuel assembly

    International Nuclear Information System (INIS)

    Kurihara, Kunitoshi; Azekura, Kazuo.

    1992-01-01

    In a reactor core of a heavy water moderated light water cooled pressure tube type reactor, no sufficient effects have been obtained for the transfer width to a negative side of void reactivity change in a region of a great void coefficient. Then, a moderation region divided into upper and lower two regions is disposed at the central portion of a fuel assembly. Coolants flown into the lower region can be discharged to the cooling region from an opening disposed at the upper end portion of the lower region. Light water flows from the lower region of the moderator region to the cooling region of the reactor core upper portion, to lower the void coefficient. As a result, the reactivity performance at low void coefficient, i.e., a void reaction rate is transferred to the negative side. Thus, this flattens the power distribution in the fuel assembly, increases the thermal margin and enables rapid operaiton and control of the reactor core, as well as contributes to the increase of fuel burnup ratio and reduction of the fuel cycle cost. (N.H.)

  13. Fuel assembly

    International Nuclear Information System (INIS)

    Chaki, Masao; Nishida, Koji; Karasawa, Hidetoshi; Kanazawa, Toru; Orii, Akihito; Nagayoshi, Takuji; Kashiwai, Shin-ichi; Masuhara, Yasuhiro

    1998-01-01

    The present invention concerns a fuel assembly, for a BWR type nuclear reactor, comprising fuel rods in 9 x 9 matrix. The inner width of the channel box is about 132mm and the length of the fuel rods which are not short fuel rods is about 4m. Two water rods having a circular cross section are arranged on a diagonal line in a portion of 3 x 3 matrix at the center of the fuel assembly, and two fuel rods are disposed at vacant spaces, and the number of fuel rods is 74. Eight fuel rods are determined as short fuel rods among 74 fuel rods. Assuming the fuel inventory in the short fuel rod as X(kg), and the fuel inventory in the fuel rods other than the short fuel rods as Y(kg), X and Y satisfy the relation: X + Y ≥ 173m, Y ≤ - 9.7X + 292, Y ≤ - 0.3X + 203 and X > 0. Then, even when the short fuel rods are used, the fuel inventory is increased and fuel economy can be improved. (I.N.)

  14. Fuel assembly

    International Nuclear Information System (INIS)

    Fushimi, Atsushi; Shimada, Hidemitsu; Aoyama, Motoo; Nakajima, Junjiro

    1998-01-01

    In a fuel assembly for an n x n lattice-like BWR type reactor, n is determined to 9 or greater, and the enrichment degree of plutonium is determined to 4.4% by weight or less. Alternatively, n is determined to 10 or greater, and the enrichment degree of plutonium is determined to 5.2% by weight or less. An average take-out burnup degree is determined to 39GWd/t or less, and the matrix is determined to 9 x 9 or more, or the average take-out burnup degree is determined to 51GWd/t, and the matrix is determined to 10 x 10 or more and the increase of the margin of the maximum power density obtained thereby is utilized for the compensation of the increase of distortion of power distribution due to decrease of the kinds of plutonium enrichment degree, thereby enabling to reduce the kind of the enrichment degree of MOX fuel rods to one. As a result, the manufacturing step for fuel pellets can be simplified to reduce the manufacturing cost for MOX fuel assemblies. (N.H.)

  15. General Assembly

    CERN Multimedia

    Staff Association

    2015-01-01

    Mardi 5 mai à 11 h 00 Salle 13-2-005 Conformément aux statuts de l’Association du personnel, une Assemblée générale ordinaire est organisée une fois par année (article IV.2.1). Projet d’ordre du jour : 1- Adoption de l’ordre du jour. 2- Approbation du procès-verbal de l’Assemblée générale ordinaire du 22 mai 2014. 3- Présentation et approbation du rapport d’activités 2014. 4- Présentation et approbation du rapport financier 2014. 5- Présentation et approbation du rapport des vérificateurs aux comptes pour 2014. 6- Programme 2015. 7- Présentation et approbation du projet de budget 2015 et taux de cotisation pour 2015. 8- Pas de modifications aux Statuts de l'Association du personnel proposée. 9- Élections des membres de la Commission é...

  16. General Assembly

    CERN Multimedia

    Staff Association

    2017-01-01

    Conformément aux statuts de l’Association du personnel, une Assemblée générale ordinaire est organisée une fois par année (article IV.2.1). Projet d’ordre du jour : Adoption de l’ordre du jour. Approbation du procès-verbal de l’Assemblée générale ordinaire du 5 avril 2016. Présentation et approbation du rapport d’activités 2016. Présentation et approbation du rapport financier 2016. Présentation et approbation du rapport des vérificateurs aux comptes pour 2016. Programme de travail 2017. Présentation et approbation du projet de budget 2017 Approbation du taux de cotisation pour 2018. Modifications aux Statuts de l'Association du personnel proposées. Élections des membres de la Commission électorale. Élections des vérifica...

  17. General Assembly

    CERN Multimedia

    Staff Association

    2016-01-01

    Mardi 5 avril à 11 h 00 BE Auditorium Meyrin (6-2-024) Conformément aux statuts de l’Association du personnel, une Assemblée générale ordinaire est organisée une fois par année (article IV.2.1). Projet d’ordre du jour : Adoption de l’ordre du jour. Approbation du procès-verbal de l’Assemblée générale ordinaire du 5 mai 2015. Présentation et approbation du rapport d’activités 2015. Présentation et approbation du rapport financier 2015. Présentation et approbation du rapport des vérificateurs aux comptes pour 2015. Programme de travail 2016. Présentation et approbation du projet de budget 2016 Approbation du taux de cotisation pour 2017. Modifications aux Statuts de l'Association du personnel proposée. Élections des membres de la Commissio...

  18. General assembly

    CERN Multimedia

    Staff Association

    2015-01-01

    Mardi 5 mai à 11 h 00 Salle 13-2-005 Conformément aux statuts de l’Association du personnel, une Assemblée générale ordinaire est organisée une fois par année (article IV.2.1). Projet d’ordre du jour : Adoption de l’ordre du jour. Approbation du procès-verbal de l’Assemblée générale ordinaire du 22 mai 2014. Présentation et approbation du rapport d’activités 2014. Présentation et approbation du rapport financier 2014. Présentation et approbation du rapport des vérificateurs aux comptes pour 2014. Programme 2015. Présentation et approbation du projet de budget 2015 et taux de cotisation pour 2015. Pas de modifications aux Statuts de l'Association du personnel proposée. Élections des membres de la Commission électorale. &am...

  19. Evaluation of a combined drug-delivery system for proteins assembled with polymeric nanoparticles and porous microspheres; characterization and protein integrity studies.

    Science.gov (United States)

    Alcalá-Alcalá, Sergio; Benítez-Cardoza, Claudia G; Lima-Muñoz, Enrique J; Piñón-Segundo, Elizabeth; Quintanar-Guerrero, David

    2015-07-15

    This work presents an evaluation of the adsorption/infiltration process in relation to the loading of a model protein, α-amylase, into an assembled biodegradable polymeric system, free of organic solvents and made up of poly(D,L-lactide-co-glycolide) acid (PLGA). Systems were assembled in a friendly aqueous medium by adsorbing and infiltrating polymeric nanoparticles into porous microspheres. These assembled systems are able to load therapeutic amounts of the drug through adsorption of the protein onto the large surface area characteristic of polymeric nanoparticles. The subsequent infiltration of nanoparticles adsorbed with the protein into porous microspheres enabled the controlled release of the protein as a function of the amount of infiltrated nanoparticles, since the surface area available on the porous structure is saturated at different levels, thus modifying the protein release rate. Findings were confirmed by both the BET technique (N2 isotherms) and in vitro release studies. During the adsorption process, the pH of the medium plays an important role by creating an environment that favors adsorption between the surfaces of the micro- and nano-structures and the protein. Finally, assays of α-amylase activity using 2-chloro-4-nitrophenyl-α-D-maltotrioside (CNP-G3) as the substrate and the circular dichroism technique confirmed that when this new approach was used no conformational changes were observed in the protein after release. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Tuskegee University experience challenges conventional wisdom: is integrative bioethics practice the new ethics for the public's health?

    Science.gov (United States)

    Sodeke, Stephen Olufemi

    2012-11-01

    The Tuskegee University National Center for Bioethics in Research and Health Care was established in 1999 in partial response to the Presidential Apology for the United States Public Health Service's Study of Untreated Syphilis in the Negro Male conducted in Macon County, Alabama, from 1932 to 1972. The Center's mission of promoting equity and justice in health and health care for African Americans and other underserved populations employs an integrative bioethics approach informed by moral vision. Etymological and historical analyses are used to delineate the meaning and evolution of bioethics and to provide a basis for Tuskegee's integrative bioethics niche. Unlike mainstream bioethics, integrative bioethics practice is holistic in orientation, and more robust for understanding the epistemic realities of minority life, health disparities, and population health. The conclusion is that integrative bioethics is relevant to the survival of all people, not just a privileged few; it could be the new ethics for the public's health.

  1. Renewable energy-driven desalination technologies: A comprehensive review on challenges and potential applications of integrated systems

    KAUST Repository

    Ghaffour, NorEddine; Bundschuh, Jochen; Mahmoudi, Hacè ne; Goosen, Mattheus F A

    2015-01-01

    desalination technologies. Innovative and sustainable desalination processes which are suitable for integrated RE systems are presented. An assessment of the benefits of these technologies and their limitations are also discussed.

  2. Cultural Integration and Cross–Cultural Management Challenges in the Central European Countries:Lithuania and Poland

    OpenAIRE

    GREBLIKAITĖ, JOLITA; SROKA, WŁODZIMIERZ; DAUGĖLIENĖ, RASA; KUROWSKA–PYSZ, JOANNA

    2017-01-01

    The article focused on disclosing the situation of cultural integration in Lithuania and Poland leading to the different issues of cross–cultural management in labour market and companies activity. As the main research method, a critical analysis of scientific literature on cultural integration and cross–cultural management applied in the companies as well as secondary research data and legal documents are analysed focusing on both countries – Lithuania and Poland. Practical examples' analysi...

  3. Achieving development goals for HIV, tuberculosis and malaria in sub-Saharan Africa through integrated antenatal care: barriers and challenges.

    Science.gov (United States)

    Fowkes, Freya J I; Draper, Bridget L; Hellard, Margaret; Stoové, Mark

    2016-12-12

    The global health community is currently transitioning from the Millennium Development Goals (MDGs) to the Sustainable Development Goals (SDGs). Unfortunately, progress towards maternal, newborn and infant health MDGs has lagged significantly behind other key health goals, demanding a renewed global effort in this key health area. The World Health Organization and other institutions heralded integrated antenatal care (ANC) as the best way to address the inter-related health issues of HIV, tuberculosis (TB) and malaria in the high risk groups of pregnant women and infants; integrated ANC services also offer a mechanism to address slow progress towards improved maternal health. There is remarkably limited evidence on best practice approaches of program implementation, acceptability and effectiveness for integrated ANC models targeting multiple diseases. Here, we discuss current integrated ANC global guidelines and the limited literature describing integrated ANC implementation and evidence for their role in addressing HIV, malaria and TB during pregnancy in sub-Saharan Africa. We highlight the paucity of data on the effectiveness of integrated ANC models and identify significant structural barriers in the health system (funding, infrastructure, distribution, human resources), the adoption system (limited buy-in from implementers, leadership, governance) and, in the broader context, patient-centred barriers (fear, stigma, personal burdens) and barriers in funding structures. We highlight recommendations for action and discuss avenues for the global health community to develop systems to integrate multiple disease programs into ANC models of care that better address these three priority infectious diseases. With the current transition to the SDGs and concerns regarding the failure to meet maternal health MDGs, the global health community, researchers, implementers and funding bodies must work together to ensure the establishment of quality operational and

  4. Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast

    International Nuclear Information System (INIS)

    Kim, Kyoung-Dong; Chung, Woo-Hyun; Kim, Hyo-Jin; Lee, Kyung-Chang; Roe, Jung-Hye

    2010-01-01

    Mitochondrial monothiol glutaredoxins that bind Fe-S cluster are known to participate in Fe-S cluster assembly. However, their precise role has not been well understood. Among three monothiol glutaredoxins (Grx3, 4, and 5) in Schizosaccharomyces pombe only Grx5 resides in mitochondria. The Δgrx5 mutant requires cysteine on minimal media, and does not grow on non-fermentable carbon source such as glycerol. We found that the mutant is low in the activity of Fe-S enzymes in mitochondria as well as in the cytoplasm. Screening of multi-copy suppressor of growth defects of the mutant identified isa1 + gene encoding a putative A-type Fe-S scaffold, in addition to mas5 + and hsc1 + genes encoding putative chaperones for Fe-S assembly process. Examination of other scaffold and chaperone genes revealed that isa2 + , but not isu1 + and ssc1 + , complemented the growth phenotype of Δgrx5 mutant as isa1 + did, partly through restoration of Fe-S enzyme activities. The mutant also showed a significant decrease in the amount of mitochondrial DNA. We demonstrated that Grx5 interacts in vivo with Isa1 and Isa2 proteins in mitochondria by observing bimolecular fluorescence complementation. These results indicate that Grx5 plays a central role in Fe-S assembly process through interaction with A-type Fe-S scaffold proteins Isa1 and Isa2, each of which is an essential protein in S. pombe, and supports mitochondrial genome integrity as well as Fe-S assembly.

  5. Overcoming challenges integrating patient-generated data into the clinical EHR: lessons from the CONtrolling Disease Using Inexpensive IT--Hypertension in Diabetes (CONDUIT-HID) Project.

    Science.gov (United States)

    Marquard, Jenna L; Garber, Lawrence; Saver, Barry; Amster, Brian; Kelleher, Michael; Preusse, Peggy

    2013-10-01

    The CONDUIT-HID intervention integrates patients' electronic blood pressure measurements directly into the clinical EHR using Microsoft HealthVault as an intermediary data store. The goal of this paper is to describe generalizable categories of patient and technical challenges encountered in the development and implementation of this inexpensive, commercial off-the-shelf consumer health informatics intervention, examples of challenges within each category, and how the example challenges were resolved prior to conducting an RCT of the intervention. The research team logged all challenges and mediation strategies during the technical development of the intervention, conducted home visits to observe patients using the intervention, and conducted telephone calls with patients to understand challenges they encountered. We then used these data to iteratively refine the intervention. The research team identified a variety of generalizable categories of challenges associated with patients uploading data from their homes, patients uploading data from clinics because they did not have or were not comfortable using home computers, and patients establishing the connection between HealthVault and the clinical EHR. Specific challenges within these categories arose because: (1) the research team had little control over the device and application design, (2) multiple vendors needed to coordinate their actions and design changes, (3) the intervention use cases were not anticipated by the device and application designers, (4) PHI accessed on clinic computers needed to be kept secure, (5) the research team wanted the data in the clinical EHR to be valid and reliable, (6) patients needed the ability to share only the data they wanted, and (7) the development of some EHR functionalities were new to the organization. While these challenges were varied and complex, the research team was able to successfully resolve each one prior to the start of the RCT. By identifying these

  6. Modelling reversible execution of robotic assembly

    DEFF Research Database (Denmark)

    Laursen, Johan Sund; Ellekilde, Lars Peter; Schultz, Ulrik Pagh

    2018-01-01

    Programming robotic assembly for industrial small-batch production is challenging; hence, it is vital to increase robustness and reduce development effort in order to achieve flexible robotic automation. A human who has made an assembly error will often simply undo the process until the error is ...

  7. Fuel assembly

    International Nuclear Information System (INIS)

    Ueda, Makoto; Ogiya, Shunsuke.

    1989-01-01

    For improving the economy of a BWR type reactor by making the operation cycle longer, the fuel enrichment degree has to be increased further. However, this makes the subcriticality shallower in the upper portion of the reactor core, to bring about a possibility that the reactor shutdown becomes impossible. In the present invention, a portion of fuel rod is constituted as partial length fuel rods (P-fuel rods) in which the entire stack length in the effective portion is made shorter by reducing the concentration of fissionable materials in the axial portion. A plurality of moderator rods are disposed at least on one diagonal line of a fuel assembly and P-fuel rods are arranged at a position put between the moderator rods. This makes it possible to reactor shutdown and makes the axial power distribution satisfactory even if the fuel enrichment degree is increased. (T.M.)

  8. Fuel assembly

    International Nuclear Information System (INIS)

    Bando, Masaru.

    1993-01-01

    As neutron irradiation progresses on a fuel assembly of an FBR type reactor, a strong force is exerted to cause ruptures if the arrangement of fuel elements is not displaced, whereas the fuel elements may be brought into direct contact with each other not by way of spacers to cause burning damages if the arrangement is displaced. In the present invention, the circumference of fuel elements arranged in a normal triangle lattice is surrounded by a wrapper tube having a hexagonal cross section, wire spacers are wound therearound, and deformable spacers are distributed to optional positions for fuel elements in the wrapper tube. Interaction between the fuel elements caused by irradiation is effectively absorbed, thereby enabling to delay the occurrence of the rupture and burning damages of the elements. (N.H.)

  9. Fuel assembly

    International Nuclear Information System (INIS)

    Wataumi, Kazutoshi; Tajiri, Hiroshi.

    1992-01-01

    In a fuel assembly of a BWR type reactor, a pellet to be loaded comprises an external layer of fissile materials containing burnable poisons and an internal layer of fissile materials not containing burnable poison. For example, there is provided a dual type pellet comprising an external layer made of UO 2 incorporated with Gd 2 O 3 at a predetermined concentration as the burnable poisons and an internal layer made of UO 2 not containing Gd 2 O 3 . The amount of the burnable poisons required for predetermined places is controlled by the thickness of the ring of the external layer. This can dissipate an unnecessary poisoning effect at the final stage of the combustion cycle. Further, since only one or a few kinds of powder mixture of the burnable poisons and the fissile materials is necessary, production and product control can be facilitated. (I.N.)

  10. Fuel assembly

    International Nuclear Information System (INIS)

    Ishibashi, Yoko; Aoyama, Motoo; Oyama, Jun-ichi.

    1995-01-01

    Burnable poison-incorporating fuel rods of a first group are disposed in a region in adjacent with a water rod having a large diameter (neutron moderator rod) disposed to the central portion of a fuel assembly. Burnable poison-incorporating fuel rods of a second group are disposed to a region other than peripheral zone in adjacent with a channel box and corners positioned at an inner zone, in adjacent with the channel box. The average concentration of burnable poisons of the burnable poison-incorporating fuel rods of the first group is made greater than that of the second group. With such a constitution, when the burnable poisons of the first group are burnt out, the burnable poisons of the second group are also burnt out at the same time. Accordingly, an amount of burnable poisons left unburnt at the final stage of the operation cycle is reduced, to improve the reactivity. This can improve the economical property. (I.N.)

  11. Fuel assemblies

    International Nuclear Information System (INIS)

    Yoshioka, Ritsuo.

    1983-01-01

    Purpose: To improve the operation performance of a BWR type reactor by improving the distribution of the uranium enrichment and the incorporation amount of burnable poisons in fuel assemblies. Constitution: The average enrichment of uranium 235 is increased in the upper portion as compared with that in the lower portion, while the incorporation amount of burnable poisons is increased in an upper portion as compared with that in the lower portion. The difference in the incorporation amount of the burnable poisons between the upper and lower portions is attained by charging two kinds of fuel rods; the ones incorporated with the burnable poisons over the entire length and the others incorporated with the burnable poisons only in the upper portions. (Seki, T.)

  12. An overview of the challenges in designing, integrating, and delivering BARD: a public chemical biology resource and query portal across multiple organizations, locations, and disciplines

    Science.gov (United States)

    de Souza, Andrea; Bittker, Joshua; Lahr, David; Brudz, Steve; Chatwin, Simon; Oprea, Tudor I.; Waller, Anna; Yang, Jeremy; Southall, Noel; Guha, Rajarshi; Schurer, Stephan; Vempati, Uma; Southern, Mark R.; Dawson, Eric S.; Clemons, Paul A.; Chung, Thomas D.Y.

    2015-01-01

    Recent industry-academic partnerships involve collaboration across disciplines, locations, and organizations using publicly funded “open-access” and proprietary commercial data sources. These require effective integration of chemical and biological information from diverse data sources, presenting key informatics, personnel, and organizational challenges. BARD (BioAssay Research Database) was conceived to address these challenges and to serve as a community-wide resource and intuitive web portal for public-sector chemical biology data. Its initial focus is to enable scientists to more effectively use the NIH Roadmap Molecular Libraries Program (MLP) data generated from 3-year pilot and 6-year production phases of the Molecular Libraries Probe Production Centers Network (MLPCN), currently in its final year. BARD evolves the current data standards through structured assay and result annotations that leverage the BioAssay Ontology (BAO) and other industry-standard ontologies, and a core hierarchy of assay definition terms and data standards defined specifically for small-molecule assay data. We have initially focused on migrating the highest-value MLP data into BARD and bringing it up to this new standard. We review the technical and organizational challenges overcome by the inter-disciplinary BARD team, veterans of public and private sector data-integration projects, collaborating to describe (functional specifications), design (technical specifications), and implement this next-generation software solution. PMID:24441647

  13. An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines.

    Science.gov (United States)

    de Souza, Andrea; Bittker, Joshua A; Lahr, David L; Brudz, Steve; Chatwin, Simon; Oprea, Tudor I; Waller, Anna; Yang, Jeremy J; Southall, Noel; Guha, Rajarshi; Schürer, Stephan C; Vempati, Uma D; Southern, Mark R; Dawson, Eric S; Clemons, Paul A; Chung, Thomas D Y

    2014-06-01

    Recent industry-academic partnerships involve collaboration among disciplines, locations, and organizations using publicly funded "open-access" and proprietary commercial data sources. These require the effective integration of chemical and biological information from diverse data sources, which presents key informatics, personnel, and organizational challenges. The BioAssay Research Database (BARD) was conceived to address these challenges and serve as a community-wide resource and intuitive web portal for public-sector chemical-biology data. Its initial focus is to enable scientists to more effectively use the National Institutes of Health Roadmap Molecular Libraries Program (MLP) data generated from the 3-year pilot and 6-year production phases of the Molecular Libraries Probe Production Centers Network (MLPCN), which is currently in its final year. BARD evolves the current data standards through structured assay and result annotations that leverage BioAssay Ontology and other industry-standard ontologies, and a core hierarchy of assay definition terms and data standards defined specifically for small-molecule assay data. We initially focused on migrating the highest-value MLP data into BARD and bringing it up to this new standard. We review the technical and organizational challenges overcome by the interdisciplinary BARD team, veterans of public- and private-sector data-integration projects, who are collaborating to describe (functional specifications), design (technical specifications), and implement this next-generation software solution. © 2014 Society for Laboratory Automation and Screening.

  14. Information and Communication Technology Integration into Teaching and Learning: Opportunities and Challenges for Commerce Educators in South Africa

    Science.gov (United States)

    Assan, Thomas; Thomas, Raju

    2012-01-01

    The study examined the opportunities available and challenges experienced by Commerce subjects' educators using ICT. Quantitative and qualitative descriptive research was used. Six high schools were purposely selected for the study because they are all equipped with computer laboratories. A purposive sample consisted of 138 school-based commerce…

  15. Metagenomics, metaMicrobesOnline and Kbase Data Integration (MICW - Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    Energy Technology Data Exchange (ETDEWEB)

    Dehal, Paramvir

    2011-10-12

    Berkeley Lab's Paramvir Dehal on "Managing and Storing large Datasets in MicrobesOnline, metaMicrobesOnline and the DOE Knowledgebase" at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.

  16. Exploring Challenges and Opportunities of Coproduction: USDA Climate Hub Efforts to Integrate Coproduction with Applied Research and Decision Support Tool Development in the Northwest

    Science.gov (United States)

    Roesch-McNally, G.; Prendeville, H. R.

    2017-12-01

    A lack of coproduction, the joint production of new technologies or knowledge among technical experts and other groups, is arguably one of the reasons why much scientific information and resulting decision support systems are not very usable. Increasingly, public agencies and academic institutions are emphasizing the importance of coproduction of scientific knowledge and decision support systems in order to facilitate greater engagement between the scientific community and key stakeholder groups. Coproduction has been embraced as a way for the scientific community to develop actionable scientific information that will assist end users in solving real-world problems. Increasing the level of engagement and stakeholder buy-in to the scientific process is increasingly necessary, particularly in the context of growing politicization of science and the scientific process. Coproduction can be an effective way to build trust and can build-on and integrate local and traditional knowledge. Employing coproduction strategies may enable the development of more relevant and useful information and decision support tools that address stakeholder challenges at relevant scales. The USDA Northwest Climate Hub has increasingly sought ways to integrate coproduction in the development of both applied research projects and the development of decision support systems. Integrating coproduction, however, within existing institutions is not always simple, given that coproduction is often more focused on process than products and products are, for better or worse, often the primary focus of applied research and tool development projects. The USDA Northwest Climate Hub sought to integrate coproduction into our FY2017 call for proposal process. As a result we have a set of proposals and fledgling projects that fall along the engagement continuum (see Figure 1- attached). We will share the challenges and opportunities that emerged from this purposeful integration of coproduction into the work

  17. Handling apparatus for a nuclear reactor fuel assembly

    International Nuclear Information System (INIS)

    Shallenberger, J.M.; Hornak, L.P.; Desmarchais, W.E.

    1978-01-01

    An apparatus is disclosed for handling radioactive fuel assembly during transfer operations. The radioactive fuel assembly is drawn up into a shielding sleeve which substantially reduces the level of radioactivity immediately surrounding the sleeve thereby permitting direct access by operating personnel. The lifting assembly which draws the fuel assembly up within the shielding sleeve is mounted to and forms an integral part of the handling apparatus. The shielding sleeve accompanies the fuel assembly during all of the transfer operations

  18. AutoAssemblyD: a graphical user interface system for several genome assemblers.

    Science.gov (United States)

    Veras, Adonney Allan de Oliveira; de Sá, Pablo Henrique Caracciolo Gomes; Azevedo, Vasco; Silva, Artur; Ramos, Rommel Thiago Jucá

    2013-01-01

    Next-generation sequencing technologies have increased the amount of biological data generated. Thus, bioinformatics has become important because new methods and algorithms are necessary to manipulate and process such data. However, certain challenges have emerged, such as genome assembly using short reads and high-throughput platforms. In this context, several algorithms have been developed, such as Velvet, Abyss, Euler-SR, Mira, Edna, Maq, SHRiMP, Newbler, ALLPATHS, Bowtie and BWA. However, most such assemblers do not have a graphical interface, which makes their use difficult for users without computing experience given the complexity of the assembler syntax. Thus, to make the operation of such assemblers accessible to users without a computing background, we developed AutoAssemblyD, which is a graphical tool for genome assembly submission and remote management by multiple assemblers through XML templates. AssemblyD is freely available at https://sourceforge.net/projects/autoassemblyd. It requires Sun jdk 6 or higher.

  19. Photon Upconversion and Molecular Solar Energy Storage by Maximizing the Potential of Molecular Self-Assembly.

    Science.gov (United States)

    Kimizuka, Nobuo; Yanai, Nobuhiro; Morikawa, Masa-Aki

    2016-11-29

    The self-assembly of functional molecules into ordered molecular assemblies and the fulfillment of potentials unique to their nanotomesoscopic structures have been one of the central challenges in chemistry. This Feature Article provides an overview of recent progress in the field of molecular self-assembly with the focus on the triplet-triplet annihilation-based photon upconversion (TTA-UC) and supramolecular storage of photon energy. On the basis of the integration of molecular self-assembly and photon energy harvesting, triplet energy migration-based TTA-UC has been achieved in varied molecular systems. Interestingly, some molecular self-assemblies dispersed in solution or organogels revealed oxygen barrier properties, which allowed TTA-UC even under aerated conditions. The elements of molecular self-assembly were also introduced to the field of molecular solar thermal fuel, where reversible photoliquefaction of ionic crystals to ionic liquids was found to double the molecular storage capacity with the simultaneous pursuit of switching ionic conductivity. A future prospect in terms of innovating molecular self-assembly toward molecular systems chemistry is also discussed.

  20. Fostering Creativity in the Classroom through Animated Storytelling - Challenges and Potentials for Arts-integration in 21st. Century Learning

    DEFF Research Database (Denmark)

    Gjedde, Lisa

    2016-01-01

    educators aware of the importance of integrating digital creativity in the teaching of the curriculum. However, in order to facilitate the integration of arts-based learning into the curriculum - not only as a subject but as a pathway to learning - new tools, competencies and mindsets are needed. This paper...... as a creative pathway to learning in primary education.......Creativity has been termed one of the most important skills of the 21st. Century classroom. While a traditional approach to education has not had a big emphasis on creativity in most subjects, the emerging learner-centered paradigm, as well as learners’ everday use of media, is making many...

  1. Robotically Assembled Aerospace Structures: Digital Material Assembly using a Gantry-Type Assembler

    Science.gov (United States)

    Trinh, Greenfield; Copplestone, Grace; O'Connor, Molly; Hu, Steven; Nowak, Sebastian; Cheung, Kenneth; Jenett, Benjamin; Cellucci, Daniel

    2017-01-01

    This paper evaluates the development of automated assembly techniques for discrete lattice structures using a multi-axis gantry type CNC machine. These lattices are made of discrete components called "digital materials." We present the development of a specialized end effector that works in conjunction with the CNC machine to assemble these lattices. With this configuration we are able to place voxels at a rate of 1.5 per minute. The scalability of digital material structures due to the incremental modular assembly is one of its key traits and an important metric of interest. We investigate the build times of a 5x5 beam structure on the scale of 1 meter (325 parts), 10 meters (3,250 parts), and 30 meters (9,750 parts). Utilizing the current configuration with a single end effector, performing serial assembly with a globally fixed feed station at the edge of the build volume, the build time increases according to a scaling law of n4, where n is the build scale. Build times can be reduced significantly by integrating feed systems into the gantry itself, resulting in a scaling law of n3. A completely serial assembly process will encounter time limitations as build scale increases. Automated assembly for digital materials can assemble high performance structures from discrete parts, and techniques such as built in feed systems, parallelization, and optimization of the fastening process will yield much higher throughput.

  2. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    , while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions...... of equality in the three societies. Finally, it shows that family relations play a central role in immigrants’ and refugees’ establishment of a new life in the receiving societies, even though the welfare society takes on many of the social and economic functions of the family....

  3. Challenges in the Integration of Multimedia by History Teachers in the North West Province of South Africa

    Science.gov (United States)

    Bester, Susanna Jacoba

    2016-01-01

    Today's learners are born into a multimedia world and feel quite comfortable in an electronic learning environment. The high-quality sound, realistic colour images, graphics, narrations, real-time recordings and full motion videos from multimedia, which are integrated in History lessons, are what the learners of today want and need in their…

  4. Social Media Integration into State-Operated Fusion Centers and Local Law Enforcement: Potential Uses and Challenges

    Science.gov (United States)

    2010-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited SOCIAL MEDIA...DATE December 2010 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Social Media Integration into State-Operated Fusion...technologies, particularly social media, within fusion centers and local law enforcement entities could enable a more expedient exchange of information among

  5. Generational, Cultural, and Linguistic Integration for Literacy Learning and Teaching in Uganda: Pedagogical Possibilities, Challenges, and Lessons from One NGO

    Science.gov (United States)

    Ngaka, Willy; Graham, Ross; Masaazi, Fred Masagazi; Anyandru, Elly Moses

    2016-01-01

    This qualitative case study focuses on a volunteer-led local NGO in Uganda to examine how integrating generations, cultures, and languages is enhancing literacy learning to help ethnically and linguistically diverse rural communities survive in the prevailing globally competitive neoliberal environment. Immersing the study in the social practices…

  6. Provider Experiences with Prison Care and Aftercare for Women with Co-occurring Mental Health and Substance Use Disorders: Treatment, Resource, and Systems Integration Challenges.

    Science.gov (United States)

    Johnson, Jennifer E; Schonbrun, Yael Chatav; Peabody, Marlanea E; Shefner, Ruth T; Fernandes, Karen M; Rosen, Rochelle K; Zlotnick, Caron

    2015-10-01

    Incarcerated women with co-occurring mental health and substance use disorders (COD) face complex psychosocial challenges at community reentry. This study used qualitative methods to evaluate the perspectives of 14 prison and aftercare providers about service delivery challenges and treatment needs of reentering women with COD. Providers viewed the needs of women prisoners with COD as distinct from those of women with substance use alone and from men with COD. Providers described optimal aftercare for women with COD as including contact with the same provider before and after release, access to services within 24-72 hours after release, assistance with managing multiple social service agencies, assistance with relationship issues, and long-term follow-up. Providers also described larger service system and societal issues, including systems integration and ways in which a lack of prison and community aftercare resources impacted quality of care and reentry outcomes. Practice and policy implications are provided.

  7. Provider Experiences with Prison Care and Aftercare for Women with Co-occurring Mental Health and Substance Use Disorders: Treatment, Resource, and Systems Integration Challenges

    Science.gov (United States)

    Johnson, Jennifer E.; Schonbrun, Yael Chatav; Peabody, Marlanea E.; Shefner, Ruth T.; Fernandes, Karen M.; Rosen, Rochelle K.; Zlotnick, Caron

    2014-01-01

    Incarcerated women with co-occurring mental health and substance use disorders (COD) face complex psychosocial challenges at community reentry. This study used qualitative methods to evaluate the perspectives of 14 prison and aftercare providers about service delivery challenges and treatment needs of reentering women with COD. Providers viewed the needs of women prisoners with COD as distinct from those of women with substance use alone and from men with COD. Providers described optimal aftercare for women with COD as including contact with the same provider before and after release, access to services within 24–72 hours after release, assistance with managing multiple social service agencies, assistance with relationship issues, and long-term follow-up. Providers also described larger service system and societal issues, including systems integration and ways in which a lack of prison and community aftercare resources impacted quality of care and reentry outcomes. Practice and policy implications are provided. PMID:24595815

  8. Health system challenges to integration of mental health delivery in primary care in Kenya- perspectives of primary care health workers

    OpenAIRE

    Jenkins, Rachel; Othieno, Caleb; Okeyo, Stephen; Aruwa, Julyan; Kingora, James; Jenkins, Ben

    2013-01-01

    Background Health system weaknesses in Africa are broadly well known, constraining progress on reducing the burden of both communicable and non-communicable disease (Afr Health Monitor, Special issue, 2011, 14-24), and the key challenges in leadership, governance, health workforce, medical products, vaccines and technologies, information, finance and service delivery have been well described (Int Arch Med, 2008, 1:27). This paper uses focus group methodology to explore health worker perspecti...

  9. Genome Sequence Databases (Overview): Sequencing and Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Lapidus, Alla L.

    2009-01-01

    From the date its role in heredity was discovered, DNA has been generating interest among scientists from different fields of knowledge: physicists have studied the three dimensional structure of the DNA molecule, biologists tried to decode the secrets of life hidden within these long molecules, and technologists invent and improve methods of DNA analysis. The analysis of the nucleotide sequence of DNA occupies a special place among the methods developed. Thanks to the variety of sequencing technologies available, the process of decoding the sequence of genomic DNA (or whole genome sequencing) has become robust and inexpensive. Meanwhile the assembly of whole genome sequences remains a challenging task. In addition to the need to assemble millions of DNA fragments of different length (from 35 bp (Solexa) to 800 bp (Sanger)), great interest in analysis of microbial communities (metagenomes) of different complexities raises new problems and pushes some new requirements for sequence assembly tools to the forefront. The genome assembly process can be divided into two steps: draft assembly and assembly improvement (finishing). Despite the fact that automatically performed assembly (or draft assembly) is capable of covering up to 98% of the genome, in most cases, it still contains incorrectly assembled reads. The error rate of the consensus sequence produced at this stage is about 1/2000 bp. A finished genome represents the genome assembly of much higher accuracy (with no gaps or incorrectly assembled areas) and quality ({approx}1 error/10,000 bp), validated through a number of computer and laboratory experiments.

  10. 49 CFR 570.10 - Wheel assemblies.

    Science.gov (United States)

    2010-10-01

    ... bead through one full wheel revolution and note runout in excess of one-eighth of an inch. (c) Mounting... 49 Transportation 6 2010-10-01 2010-10-01 false Wheel assemblies. 570.10 Section 570.10... Pounds or Less § 570.10 Wheel assemblies. (a) Wheel integrity. A tire rim, wheel disc, or spider shall...

  11. Classification of assembly techniques for micro products

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Tosello, Guido; Gegeckaite, Asta

    2005-01-01

    of components and level of integration are made. This paper describes a systematic characterization of micro assembly methods. This methodology offers the opportunity of a cross comparison among different techniques to gain a choosing principle of the favourable micro assembly technology in a specific case...

  12. Fuel assembly

    International Nuclear Information System (INIS)

    Hirukawa, Koji; Sakurada, Koichi.

    1992-01-01

    In a fuel assembly for a BWR type reactor, water rods or water crosses are disposed between fuel rods, and a value with a spring is disposed at the top of the coolant flow channel thereof, which opens a discharge port when pressure is increased to greater than a predetermined value. Further, a control element for the amount of coolant flow rate is inserted retractable to a control element guide tube formed at the lower portion of the water rod or the water cross. When the amount of control elements inserted to the control element guide tube is small and the inflown coolant flow rate is great, the void coefficient at the inside of the water rod is less than 5%. On the other hand, when the control elements are inserted, the flow resistance is increased, so that the void coefficient in the water rod is greater than 80%. When the pressure in the water rod is increased, the valve with the spring is raised to escape water or steams. Then, since the variation range of the change of the void coefficient can be controlled reliably by the amount of the control elements inserted, and nuclear fuel materials can be utilized effectively. (N.H.)

  13. Fuel assembly

    International Nuclear Information System (INIS)

    Hiraiwa, Koji; Ueda, Makoto

    1989-01-01

    In a fuel assembly used for a light water cooled reactor such as a BWR type reactor, a water rod is divided axially into an upper outer tube and a lower outer tube by means of a plug disposed from the lower end of a water rod to a position 1/4 - 1/2 of the entire length for the water rod. Inlet apertures and exit apertures for moderators are respectively perforated for the divided outer tube and upper and lower portions. Further, an upper inner tube with less neutron irradiation growing amount than the outer tube is perforated on the plug in the outer tube, while a lower inner tube with greater neutron irradiation growing amount than the outer tube is suspended from the lower surface of the plug in the outer tube. Then, the opening area for the exit apertures disposed to the upper outer tube and the lower outer tube is controlled depending on the difference of the neutron irradiation growing amount between the upper inner tube and the upper outer tube, and the difference of the neutron irradiation growing amount between the lower inner tube and the lower outer tube. This enables effective spectral shift operation and improve the fuel economy. (T.M.)

  14. Fuel assembly

    International Nuclear Information System (INIS)

    Yamazaki, Hajime.

    1995-01-01

    In a fuel assembly having fuel rods of different length, fuel pellets of mixed oxides of uranium and plutonium are loaded to a short fuel rod. The volume ratio of a pellet-loaded portion to a plenum portion of the short fuel rod is made greater than the volume ratio of a fuel rod to which uranium fuel pellets are loaded. In addition, the volume of the plenum portion of the short fuel rod is set greater depending on the plutonium content in the loaded fuel pellets. MOX fuel pellets are loaded on the short fuel rods having a greater degree of freedom relevant to the setting for the volume of the plenum portion compared with that of a long rod fuel, and the volume of the plenum portion is ensured greater depending on the plutonium content. Even if a large amount of FP gas and He gas are discharged from the MOX fuels compared with that from the uranium fuels, the internal pressure of the MOX fuel rod during operation is maintained substantially identical with that of the uranium fuel rod, so that a risk of generating excess stresses applied to the fuel cladding tubes and rupture of fuels are greatly reduced. (N.H.)

  15. Fuel assembly

    International Nuclear Information System (INIS)

    Nakajima, Akiyoshi; Bessho, Yasunori; Aoyama, Motoo; Koyama, Jun-ichi; Hirakawa, Hiromasa; Yamashita, Jun-ichi; Hayashi, Tatsuo

    1998-01-01

    In a fuel assembly of a BWR type reactor in which a water rod of a large diameter is disposed at the central portion, the cross sectional area perpendicular to the axial direction comprises a region a of a fuel rod group facing to a wide gap water region to which a control rod is inserted, a region b of a fuel rod group disposed on the side of the wide gap water region other than the region a, a region d of a fuel rod group facing to a narrow gap water region and a region c of a fuel rod group disposed on the side of the narrow gap water region other than the region d. When comparing an amount of fission products contained in the four regions relative to that in the entire regions and average enrichment degrees of fuel rods for the four regions, the relative amount and the average enrichment degree of the fuel rod group of the region a is minimized, and the relative amount and the average enrichment degree of the fuel rod group in the region b is maximized. Then, reactor shut down margin during cold operation can be improved while flattening the power in the cross section perpendicular to the axial direction. (N.H.)

  16. Trends and challenges toward integration of traditional medicine in formal health-care system: Historical perspectives and appraisal of education curricula in Sub-Sahara Africa

    Science.gov (United States)

    Innocent, Ester

    2016-01-01

    The population residing Sub-Sahara Africa (SSA) continues to suffer from communicable health problems such as HIV/AIDS, malaria, tuberculosis, and various neglected tropical as well as non-communicable diseases. The disease burden is aggravated by shortage of medical personnel and medical supplies such as medical devices and minimal access to essential medicine. For long time, human beings through observation and practical experiences learned to use different plant species that led to the emergence of traditional medicine (TM) systems. The ancient Pharaonic Egyptian TM system is one of the oldest documented forms of TM practice in Africa and the pioneer of world’s medical science. However, the medical practices diffused very fast to other continents being accelerated by advancement of technologies while leaving Africa lagging behind in the integration of the practice in formal health-care system. Challenging issues that drag back integration is the development of education curricula for training TM experts as the way of disseminating the traditional medical knowledge and practices imbedded in African culture. The few African countries such as Ghana managed to integrate TM products in the National Essential Medicine List while South Africa, Sierra Leone, and Tanzania have TM products being sold over the counters due to the availability of education training programs facilitated by research. This paper analyses the contribution of TM practice and products in modern medicine and gives recommendations that Africa should take in the integration process to safeguard the SSA population from disease burdens. PMID:27366358

  17. Trends and challenges toward integration of traditional medicine in formal health-care system: Historical perspectives and appraisal of education curricula in Sub-Sahara Africa.

    Science.gov (United States)

    Innocent, Ester

    2016-01-01

    The population residing Sub-Sahara Africa (SSA) continues to suffer from communicable health problems such as HIV/AIDS, malaria, tuberculosis, and various neglected tropical as well as non-communicable diseases. The disease burden is aggravated by shortage of medical personnel and medical supplies such as medical devices and minimal access to essential medicine. For long time, human beings through observation and practical experiences learned to use different plant species that led to the emergence of traditional medicine (TM) systems. The ancient Pharaonic Egyptian TM system is one of the oldest documented forms of TM practice in Africa and the pioneer of world's medical science. However, the medical practices diffused very fast to other continents being accelerated by advancement of technologies while leaving Africa lagging behind in the integration of the practice in formal health-care system. Challenging issues that drag back integration is the development of education curricula for training TM experts as the way of disseminating the traditional medical knowledge and practices imbedded in African culture. The few African countries such as Ghana managed to integrate TM products in the National Essential Medicine List while South Africa, Sierra Leone, and Tanzania have TM products being sold over the counters due to the availability of education training programs facilitated by research. This paper analyses the contribution of TM practice and products in modern medicine and gives recommendations that Africa should take in the integration process to safeguard the SSA population from disease burdens.

  18. The integrated disease surveillance and response system in northern Ghana: challenges to the core and support functions

    OpenAIRE

    Adokiya, Martin Nyaaba; Awoonor-Williams, John K.; Beiersmann, Claudia; Müller, Olaf

    2015-01-01

    Background: The integrated disease surveillance and response (IDSR) strategy was adopted in Ghana over a decade ago, yet gaps still remain in its proper functioning. The objective of this study was to assess the core and support functions of the IDSR system at the periphery level of the health system in northern Ghana. Methods: A qualitative study has been conducted among 18 key informants in two districts of Upper East Region. The respondents were from 9 health facilities considered repres...

  19. The challenges to gender integration in the career fire services: a comparative case study of men in nursing

    Science.gov (United States)

    2017-03-01

    pdf. 191 David F. Burrelli, Women in the Armed Forces (CRS Report No. 92008) ( Washington , DC: Congressional Research Service, 1998), 1, https...IB92008) Washington , DC: Congressional Research Service, 1998. https://www.hsdl.org/?view&did=718051. Carreiras, Helena. Gender and the Military: Women ...GENDER INTEGRATION IN THE CAREER FIRE SERVICES: A COMPARATIVE CASE STUDY OF MEN IN NURSING by Anna L. Schermerhorn-Collins March 2017

  20. A study of integrated cathode assembly for electrolytic reduction of uranium oxide in LiCl-Li2O molten salt

    International Nuclear Information System (INIS)

    Park, Sung Bin; Seo, Jung Seok; Kang, Dae Seung; Kwon, Sun Kil; Park, Seong Won

    2004-01-01

    Interest of electrolytic reduction of uranium oxide is increasing in treatment of spent metal fuels. Argonne National Laboratory (ANL) has reported the experimental results of electrochemical reduction of uranium oxide fuel in bench-scale apparatus with cyclic voltammetry, and has designed high-capacity reduction (HCR) cells and conducted three kg-scale UO 2 reduction runs. From the cyclic voltammograms, the mechanism of electrolytic reduction of metal oxides is analyzed. The uranium oxide in LiCl-Li 2 O is converted to uranium metal according to the two mechanism; direct and indirect electrolytic reduction. In this study, cyclic voltammograms for LiCl-3wt% Li 2 O system and U 3 O 8 -LiCl-3wt% Li 2 O system using the 325-mesh stainless steel screen in cathode assembly have been obtained. Direct electrolytic reduction of uranium oxide in LiCl-3wt% Li 2 O molten salt has been conducted