WorldWideScience

Sample records for certified reference materials

  1. Certified reference materials for organic analysis

    International Nuclear Information System (INIS)

    This presentation discusses the requirements for certified reference materials (CRMs) to be used in measurements of residues of pesticides in food and environmental samples. It deals with the types of CRMs, matrix selection, sample preparation and representativeness. It also discusses CRM validity period and gives some examples of CRM preparation

  2. Development studies of captopril certified reference material

    Directory of Open Access Journals (Sweden)

    Raquel Nogueira

    2011-06-01

    Full Text Available This paper describes the studies performed with the candidate Certified Reference Material (CRM of captopril, the first CRM of an active pharmaceutical ingredient (API in Brazil, including determination of impurities (organic, inorganic and volatiles, homogeneity testing, short- and long-term stability studies, calculation of captopril content using the mass balance approach, and estimation of the associated measurement uncertainty.Este artigo descreve os estudos realizados com o candidato a Material de Referência Certificado (MRC de captopril, primeiro MRC de fármacos no Brasil, incluindo a determinação de impurezas (orgânicas, inorgânicas e voláteis, testes de homogeneidade, testes de estabilidade de curta e longa duração, cálculo do teor de captopril por balanço de massa e estimativa da incerteza de medição associada ao valor certificado.

  3. Certified reference materials of trace elements in water

    Indian Academy of Sciences (India)

    A K Agrawal

    2005-07-01

    Measurement of trace elements is playing a vital role in industries and various sectors of science and technology including semiconductors, food, health and environmental sectors. In most of the cases a small error in measurement can vitiate all the measures taken for quality control and management. Many decisions regarding the suitability of material/products are based on the analysis. To reduce or eliminate the rejection rate of the products, accurate and reliable measurements are needed which can be achieved by the use of certified reference materials (CRMs). Their use in calibration of analytical equipments and validation of test methods ensures high quality in measurements and it provides traceability to the measurement data with national/international measurement systems (SI unit) also. In the present scenario of globalization of economy, use of certified reference materials (CRMs) in measurements is essential for global acceptance of products and test reports. Their use fulfil a mandatory requirement of international quality systems (ISO 9000, ISO/IEC standard 17025) including our national accreditation body, National Accreditation Board for Testing and Calibration Laboratories (NABL), World Trade Organization (WTO) etc. International manufacturers of CRMs are meeting most of the requirement of CRMs of the country. To meet the demand of CRMs indigenously, the National Physical Laboratory, India initiated a national programme on preparation and dissemination of certified reference materials.

  4. Bias detection and certified reference materials for random measurands

    Science.gov (United States)

    Rukhin, Andrew L.

    2015-12-01

    A problem that frequently occurs in metrology is the bias checking of data obtained by a laboratory against the specified value and uncertainty estimate given in the certificate of analysis. The measurand—a property of a certified reference material (CRM)—is supposed to be random with a normal distribution whose parameters are given by the certificate specifications. The laboratory’s data from subsequent measurements of the CRM (a CRM experiment) are summarized by the sample mean value and its uncertainty which is commonly based on a repeatability standard deviation. New confidence intervals for the lab’s bias are derived. Although they may lack intuitive appeal, those obtained by using higher order asymptotic methods, compared and contrasted in this paper, are recommended.

  5. Certified reference materials and reference methods for nuclear safeguards and security.

    Science.gov (United States)

    Jakopič, R; Sturm, M; Kraiem, M; Richter, S; Aregbe, Y

    2013-11-01

    Confidence in comparability and reliability of measurement results in nuclear material and environmental sample analysis are established via certified reference materials (CRMs), reference measurements, and inter-laboratory comparisons (ILCs). Increased needs for quality control tools in proliferation resistance, environmental sample analysis, development of measurement capabilities over the years and progress in modern analytical techniques are the main reasons for the development of new reference materials and reference methods for nuclear safeguards and security. The Institute for Reference Materials and Measurements (IRMM) prepares and certifices large quantities of the so-called "large-sized dried" (LSD) spikes for accurate measurement of the uranium and plutonium content in dissolved nuclear fuel solutions by isotope dilution mass spectrometry (IDMS) and also develops particle reference materials applied for the detection of nuclear signatures in environmental samples. IRMM is currently replacing some of its exhausted stocks of CRMs with new ones whose specifications are up-to-date and tailored for the demands of modern analytical techniques. Some of the existing materials will be re-measured to improve the uncertainties associated with their certified values, and to enable laboratories to reduce their combined measurement uncertainty. Safeguards involve the quantitative verification by independent measurements so that no nuclear material is diverted from its intended peaceful use. Safeguards authorities pay particular attention to plutonium and the uranium isotope (235)U, indicating the so-called 'enrichment', in nuclear material and in environmental samples. In addition to the verification of the major ratios, n((235)U)/n((238)U) and n((240)Pu)/n((239)Pu), the minor ratios of the less abundant uranium and plutonium isotopes contain valuable information about the origin and the 'history' of material used for commercial or possibly clandestine purposes, and

  6. Development of Certified Reference Materials for Diarrhetic Shellfish Poisoning Toxins, Part 2: Shellfish Matrix Materials.

    Science.gov (United States)

    McCarron, Pearse; Reeves, Kelley L; Giddings, Sabrina D; Beach, Daniel G; Quilliam, Michael A

    2016-09-01

    Okadaic acid (OA) and its analogs, dinophysistoxins-1 (DTX1) and -2 (DTX2) are lipophilic biotoxins produced by marine algae that can accumulate in shellfish and cause the human illness known as diarrhetic shellfish poisoning (DSP). Regulatory testing of shellfish is required to protect consumers and the seafood industry. Certified reference materials (CRMs) are essential for the development, validation, and quality control of analytical methods, and thus play an important role in toxin monitoring. This paper summarizes work on research and development of shellfish tissue reference materials for OA and DTXs. Preliminary work established the appropriate conditions for production of shellfish tissue CRMs for OA and DTXs. Source materials, including naturally incurred shellfish tissue and cultured algae, were screened for their DSP toxins. This preliminary work informed planning and production of a wet mussel (Mytilus edulis) tissue homogenate matrix CRM. The homogeneity and stability of the CRM were evaluated and found to be fit-for-purpose. Extraction and LC-tandem MS methods were developed to accurately certify the concentrations of OA, DTX1, and DTX2 using a combination of standard addition and matrix-matched calibration to compensate for matrix effects in electrospray ionization. The concentration of domoic acid was also certified. Uncertainties were assigned following standards and guidelines from the International Organization for Standardization. The presence of other toxins in the CRM was also assessed and information values are reported for OA and DTX acyl esters.

  7. Development of benzene, toluene, ethylbenzene and xylenes certified gaseous reference materials

    Science.gov (United States)

    Brum, M. C.; Sobrinho, D. C. G.; Fagundes, F. A.; Oudwater, R. J.; Augusto, C. R.

    2016-07-01

    The work describes the production of certified gaseous reference materials of benzene, toluene, ethylbenzene and xylenes (BTEX) in nitrogen from the gravimetric production up to the long term stability tests followed by the certifying step. The uncertainty in the amount fractions of the compounds in these mixtures was approximately 4% (relative) for the range studied from 2 to 16 µmol/mol. Also the adsorption of the BTEX on the cylinder surface and the tubing were investigated as potential uncertainty source.

  8. Certified reference materials for food packaging specific migration tests: development, validation and modelling

    NARCIS (Netherlands)

    Stoffers, N.H.

    2005-01-01

    Keywords:certified reference materials; diffusion; food contact materials; food packaging; laurolactam; migration modelling; nylon; specific migration This thesis compiles several research topics

  9. Certified Reference Material IAEA-446 for radionuclides in Baltic Sea seaweed

    DEFF Research Database (Denmark)

    Pham, M.K.; Benmansour, M.; Carvalho, F.P.;

    2014-01-01

    A Certified Reference Material (CRM) for radionuclides in seaweed (Fucus vesiculosus) from the Baltic Sea (IAEA-446) is described and the results of the certification process are presented. The 40K, 137Cs, 234U and 239þ240Pu radionuclides were certified for this material, and information values...... for 12 other radionuclides (90Sr, 99Tc, 210Pb (210Po), 226Ra, 228Ra, 228Th, 230Th, 232Th, 235U, 238U, 239Pu and 240Pu) are presented. The CRM can be used for Quality Assurance/Quality Control of analysis of radionuclides in seaweed and other biota samples, as well as for development and validation...

  10. A mussel (Mytilus edulis) tissue certified reference material for the marine biotoxins azaspiracids

    OpenAIRE

    McCarron, Pearse; Giddings, Sabrina D.; Reeves, Kelley L.; Hess, Philipp; Michael A. Quilliam

    2015-01-01

    Azaspiracids (AZAs) are lipophilic biotoxins produced by marine algae that can contaminate shellfish and cause human illness. The European Union (EU) regulates the level of AZAs in shellfish destined for the commercial market, with liquid chromatography-mass spectrometry (LC-MS) being used as the official reference method for regulatory analysis. Certified reference materials (CRMs) are essential tools for the development, validation, and quality control of LC-MS methods. This paper describes...

  11. A certified reference material for radionuclides in the water sample from Irish Sea (IAEA-443)

    DEFF Research Database (Denmark)

    Pham, M.K.; Betti, M.; Povinec, P.P.;

    2011-01-01

    A new certified reference material (CRM) for radionuclides in sea water from the Irish sea (IAEA-443) is described and the results of the certification process are presented. Ten radionuclides (3H, 40K, 90Sr, 137Cs, 234U, 235U, 238U, 238Pu, 239+240Pu and 241Am) have been certified, and information...... values on massic activities with 95% confidence intervals are given for four radionuclides (230Th, 232Th, 239Pu and 240Pu). Results for less frequently reported radionuclides (99Tc, 228Th, 237Np and 241Pu) are also reported. The CRM can be used for quality assurance/quality control of the analysis...

  12. Development and certification of a coal fly ash certified reference material for selected polycyclic aromatic hydrocarbons.

    Science.gov (United States)

    Cao, X; Xu, X; Cui, W; Xi, Z

    2001-08-01

    The development and certification of a coal fly ash certified reference material (CRM) for polycyclic aromatic hydrocarbons (PAH) is described; this is the first natural matrix CRM for organic environmental analysis in China. The homogeneity and stability of this material have been tested by HPLC. The concentrations of several PAH were determined by use of two independent, different methods--solvent extraction-HPLC analysis with UV detection coupled with fluorescence detection (FLD) and solvent extraction, isolation with a silica column, and GC analysis with flame ionization detection (FID). Five certified values were determined: phenanthrene 7.1 +/- 2.6 microg g(-1), anthracene 2.0 +/- 0.8 microg g(-1), fluoranthene 7.4 +/- 1.9 microg g(-1), pyrene 7 +/- 2 microg g(-1), and benzo[a]pyrene 1.3 +/- 0.3 microg g(-1). Reference values for several other PAH are also suggested. PMID:11583083

  13. Evaluation of a fungal collection as certified reference material producer and as a biological resource center.

    Science.gov (United States)

    Forti, Tatiana; Souto, Aline da S S; do Nascimento, Carlos Roberto S; Nishikawa, Marilia M; Hubner, Marise T W; Sabagh, Fernanda P; Temporal, Rosane Maria; Rodrigues, Janaína M; da Silva, Manuela

    2016-01-01

    Considering the absence of standards for culture collections and more specifically for biological resource centers in the world, in addition to the absence of certified biological material in Brazil, this study aimed to evaluate a Fungal Collection from Fiocruz, as a producer of certified reference material and as Biological Resource Center (BRC). For this evaluation, a checklist based on the requirements of ABNT ISO GUIA34:2012 correlated with the ABNT NBR ISO/IEC17025:2005, was designed and applied. Complementing the implementation of the checklist, an internal audit was performed. An evaluation of this Collection as a BRC was also conducted following the requirements of the NIT-DICLA-061, the Brazilian internal standard from Inmetro, based on ABNT NBR ISO/IEC 17025:2005, ABNT ISO GUIA 34:2012 and OECD Best Practice Guidelines for BRCs. This was the first time that the NIT DICLA-061 was applied in a culture collection during an internal audit. The assessments enabled the proposal for the adequacy of this Collection to assure the implementation of the management system for their future accreditation by Inmetro as a certified reference material producer as well as its future accreditation as a Biological Resource Center according to the NIT-DICLA-061. PMID:26991280

  14. Evaluation of a fungal collection as certified reference material producer and as a biological resource center

    Directory of Open Access Journals (Sweden)

    Tatiana Forti

    2016-06-01

    Full Text Available Abstract Considering the absence of standards for culture collections and more specifically for biological resource centers in the world, in addition to the absence of certified biological material in Brazil, this study aimed to evaluate a Fungal Collection from Fiocruz, as a producer of certified reference material and as Biological Resource Center (BRC. For this evaluation, a checklist based on the requirements of ABNT ISO GUIA34:2012 correlated with the ABNT NBR ISO/IEC17025:2005, was designed and applied. Complementing the implementation of the checklist, an internal audit was performed. An evaluation of this Collection as a BRC was also conducted following the requirements of the NIT-DICLA-061, the Brazilian internal standard from Inmetro, based on ABNT NBR ISO/IEC 17025:2005, ABNT ISO GUIA 34:2012 and OECD Best Practice Guidelines for BRCs. This was the first time that the NIT DICLA-061 was applied in a culture collection during an internal audit. The assessments enabled the proposal for the adequacy of this Collection to assure the implementation of the management system for their future accreditation by Inmetro as a certified reference material producer as well as its future accreditation as a Biological Resource Center according to the NIT-DICLA-061.

  15. Certified Reference Material IAEA-446 for radionuclides in Baltic Sea seaweed

    International Nuclear Information System (INIS)

    A Certified Reference Material (CRM) for radionuclides in seaweed (Fucus vesiculosus) from the Baltic Sea (IAEA-446) is described and the results of the certification process are presented. The 40K, 137Cs, 234U and 239+240Pu radionuclides were certified for this material, and information values for 12 other radionuclides (90Sr, 99Tc, 210Pb (210Po), 226Ra, 228Ra, 228Th, 230Th, 232Th, 235U, 238U, 239Pu and 240Pu) are presented. The CRM can be used for Quality Assurance/Quality Control of analysis of radionuclides in seaweed and other biota samples, as well as for development and validation of analytical methods, and for training purposes

  16. Production of trace elements in coastal sea water certified reference material NMIA MX014.

    Science.gov (United States)

    Merrick, Jeffrey P; Saxby, David L; White, Ian E A W; Antin, Luminita; Murby, E John

    2016-06-01

    A certified reference material (CRM) for trace elements in acidified sea water, NMIA MX014, has been produced by the National Measurement Institute Australia (NMIA). The CRM consists of natural coastal sea water with 12 elements (As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se and V) fortified to levels relevant to environmental regulatory testing in Australia ranging from 0.4 to 22 μg/kg. Certified values for these 12 elements were assigned using reference methods developed at NMIA, using either isotope dilution or standard addition with ICP-MS measurement. Specialised sample preparation (coprecipitation) and ICP-MS optimisation (online dilution, collision/reaction chemistry, high mass resolution) were used to negate the effect of the high level of dissolved solids. Multiple confirmatory experiments were performed in order to verify that ICP-MS spectral interferences were eliminated and to estimate the measurement uncertainty contribution from method precision and method trueness. Extensive homogeneity and stability testing was performed and the measurement uncertainty of certified values includes contributions from between-bottle homogeneity, short-term stability, medium-term stability and long-term stability. Special attention was paid to the stability of Hg due to well-known preservation problems. Acidified sea water matrix was satisfactory for stabilising Hg at 0.4 μg/kg for at least 4 years. Relative expanded uncertainties (k = 2) for the 12 certified values were between 1 and 11 %. NMIA MX014 is intended for use as a reference material for analytical method validation and quality control for quantification of trace elements in saline water and other similar sample types. PMID:27108283

  17. Certified reference materials for radionuclides in Bikini Atoll sediment (IAEA-410) and Pacific Ocean sediment (IAEA-412)

    DEFF Research Database (Denmark)

    Pham, M. K.; van Beek, P.; Carvalho, F. P.;

    2016-01-01

    The preparation and characterization of certified reference materials (CRMs) for radionuclide content in sediments collected offshore of Bikini Atoll (IAEA-410) and in the open northwest Pacific Ocean (IAEA-412) are described and the results of the certification process are presented. The certifi...

  18. Certified reference materials of agricultural products and foods bearing radioactivity from the Fukushima nuclear accident

    International Nuclear Information System (INIS)

    Certified reference materials (CRMs) for food analysis were developed in an inter-laboratory experiment for validation of measurement of radiocesium in foodstuffs. Since 2012, five series of CRMs were developed, including for brown rice grain, soybean powder, beef flake, shiitake mushroom powder and marine fish (meat and bone parts). This paper discusses the strategy of development, including choice of CRMs developed and the preparation and certification procedures applied for CRM development. In particular, some detailed data are presented for the most popular CRMs developed: brown rice grain, soybean powder and beef flake. (author)

  19. DNA copy number concentration measured by digital and droplet digital quantitative PCR using certified reference materials

    OpenAIRE

    CORBISIER Philippe; Pinheiro, Leonardo; Mazoua, Stephane; KORTEKAAS Anna Maria; CHUNG PUI YAN JENNY; GERGANOVA TSVETELINA IVANOVA; Roebben, Gert; Emons, Hendrik; Emslie, K

    2015-01-01

    The value assignment for properties of six certified reference materials (ERM-AD623a–f), each containing a plasmid DNA solution ranging from 1 million to 10 copies per μL, by using digital PCR (dPCR) with the BioMark™ HD System (Fluidigm) has been verified by applying droplet digital PCR (ddPCR) using the QX100 system (Bio-Rad). One of the critical factors in the measurement of copy number concentrations by digital PCR is the partition volume. Therefore, we determined the average droplet volu...

  20. Preparation of homogeneous thorium oxide powders for development of certified reference materials

    International Nuclear Information System (INIS)

    In view of the growing importance of Thorium Oxide (ThO2) as a fuel in nuclear power reactors, it is essential to develop Certified Reference Materials (CRMs) for trace level assay of ThO2 in order to validate analytical methods and also to assess the performance of an individual chemical laboratory. The present paper discusses the preparation of four batches of homogeneous Thorium Oxide (ThO2) powders on kilogram levels including a batch of ThO2 and Natural UO2 mixed oxide with varying amounts of impurities and also developing them as CRMs based on round robin tests. (author)

  1. Certification of the equivalent spherical diameters of silica nanoparticles in aqueous solution - Certified Reference Material ERM®-FD304

    OpenAIRE

    FRANKS Katrin; BRAUN ADELINA; CHAROUD-GOT Jean; COUTEAU Olivier; KESTENS Vikram; LAMBERTY MARIE ANDREE; Linsinger, Thomas; Roebben, Gert

    2011-01-01

    This report describes the certification of several equivalent spherical diameters of silica nanoparticles in aqueous solution, Certified Reference Material (CRM) ERM®-FD304. The CRM has been certified by the European Commission, Joint Research Centre, Institute for Reference Materials and Measurements (IRMM), Geel, BE. ERM-FD304 consists of silica nanoparticles suspended in aqueous solution. The intended use of this CRM is t o check the performance of instruments and methods that determine...

  2. Certified Reference Material IAEA-448: Soil from Oil Field Contaminated with Technically Enhanced Radium-226

    International Nuclear Information System (INIS)

    To ensure reliable evaluation of potential radiological hazards and proper decision making related to radiation protection measures, the IAEA, through the IAEA Environment Laboratories, supports Member State laboratories in their efforts to maintain readiness and to improve the quality of analytical results. It does so by producing reference materials, by developing standardized methods for sample collection and analysis, and by conducting interlaboratory comparisons and proficiency tests as tools for external quality control of analytical results. The problem of naturally occurring radioactive material (NORM) contamination is known to be widespread, occurring in oil and gas production facilities throughout the world. It has become a subject of attention in many IAEA Member States. In response to this radiological concern, facilities in many Member States have been characterizing the nature and extent of NORM in oil and gas installations and in the surrounding environment, evaluating the potential for exposure to workers and the public, and developing methods for properly managing these relatively high massic activity residues. Within this context, the IAEA Environment Laboratories, in cooperation with the Atomic Energy Commission of Syria, an IAEA Collaborating Centre, have prepared a new certified reference material of soil contaminated with NORM, identified as IAEA-448, certified for the massic activity of 226Ra. This report presents the methodologies used for the production and certification of IAEA-448

  3. A mussel (Mytilus edulis) tissue certified reference material for the marine biotoxins azaspiracids.

    Science.gov (United States)

    McCarron, Pearse; Giddings, Sabrina D; Reeves, Kelley L; Hess, Philipp; Quilliam, Michael A

    2015-04-01

    Azaspiracids (AZAs) are lipophilic biotoxins produced by marine algae that can contaminate shellfish and cause human illness. The European Union (EU) regulates the level of AZAs in shellfish destined for the commercial market, with liquid chromatography-mass spectrometry (LC-MS) being used as the official reference method for regulatory analysis. Certified reference materials (CRMs) are essential tools for the development, validation, and quality control of LC-MS methods. This paper describes the work that went into the planning, preparation, characterization, and certification of CRM-AZA-Mus, a tissue matrix CRM, which was prepared as a wet homogenate from mussels (Mytilus edulis) naturally contaminated with AZAs. The homogeneity and stability of CRM-AZA-Mus were evaluated, and the CRM was found to be fit for purpose. Extraction and LC-MS/MS methods were developed to accurately certify the concentrations of AZA1 (1.16 mg/kg), AZA2 (0.27 mg/kg), and AZA3 (0.21 mg/kg) in the CRM. Quantitation methods based on standard addition and matrix-matched calibration were used to compensate for the matrix effects in LC-MS/MS. Other toxins present in this CRM at lower levels were also measured with information values reported for okadaic acid, dinophysistoxin-2, yessotoxin, and several spirolides.

  4. A mussel (Mytilus edulis) tissue certified reference material for the marine biotoxins azaspiracids.

    Science.gov (United States)

    McCarron, Pearse; Giddings, Sabrina D; Reeves, Kelley L; Hess, Philipp; Quilliam, Michael A

    2015-04-01

    Azaspiracids (AZAs) are lipophilic biotoxins produced by marine algae that can contaminate shellfish and cause human illness. The European Union (EU) regulates the level of AZAs in shellfish destined for the commercial market, with liquid chromatography-mass spectrometry (LC-MS) being used as the official reference method for regulatory analysis. Certified reference materials (CRMs) are essential tools for the development, validation, and quality control of LC-MS methods. This paper describes the work that went into the planning, preparation, characterization, and certification of CRM-AZA-Mus, a tissue matrix CRM, which was prepared as a wet homogenate from mussels (Mytilus edulis) naturally contaminated with AZAs. The homogeneity and stability of CRM-AZA-Mus were evaluated, and the CRM was found to be fit for purpose. Extraction and LC-MS/MS methods were developed to accurately certify the concentrations of AZA1 (1.16 mg/kg), AZA2 (0.27 mg/kg), and AZA3 (0.21 mg/kg) in the CRM. Quantitation methods based on standard addition and matrix-matched calibration were used to compensate for the matrix effects in LC-MS/MS. Other toxins present in this CRM at lower levels were also measured with information values reported for okadaic acid, dinophysistoxin-2, yessotoxin, and several spirolides. PMID:25335820

  5. Fundamental studies to develop certified reference material to calibrate spectrophotometer in the ultraviolet region

    Science.gov (United States)

    da Conceição, F. C.; Borges, P. P.; Gomes, J. F. S.

    2016-07-01

    Spectrophotometry is the technique used in a great number of laboratories around the world. Quantitative determination of a high number of inorganic, organic and biological species can be made by spectrophotometry using calibrated spectrophotometers. International standards require the use of optical filters to perform the calibration of spectrophotometers. One of the recommended materials is the crystalline potassium dichromate (K2Cr2O7), which is used to prepare solutions in specific concentrations for calibration or verification of spectrophotometers in the ultraviolet (UV) spectral regions. This paper presents the results concerning the fundamental studies for developing a certified reference material (CRM) of crystalline potassium dichromate to be used as standard of spectrophotometers in order to contribute to reliable quantitative analyses.

  6. Development of a candidate certified reference material of cypermethrin in green tea

    International Nuclear Information System (INIS)

    Highlights: ► A cypermethrin CRM in green tea was developed. ► Using two isotope dilution mass spectrometry techniques for characterization. ► Certified value of 148 μg kg−1 with expanded uncertainty of ±9.2%. ► Support quality assurance of pesticide residue analysis in tea to testing. - Abstract: This paper presents the preparation of a candidate certified reference material (CRM) of cypermethrin in green tea, GLHK-11-01a according to the requirements of ISO Guide 34 and 35. Certification of the material was performed using a newly developed isotope dilution mass spectrometry (IDMS) approach, with gas chromatography high resolution mass spectrometry (GC–HRMS) and gas chromatography–tandem mass spectrometry (GC–MS/MS). Statistical analysis (one-way ANOVA) showed excellent agreement of the analytical data sets generated from the two mass spectrometric detections. The characterization methods have also been satisfactorily applied in an Asia-Pacific Metrology Program (APMP) interlaboratory comparison study. Both the GC–HRIDMS and GC–IDMS/MS methods proved to be sufficiently reliable and accurate for certification purpose. The certified value of cypermethrin in dry mass fraction was 148 μg kg−1 and the associated expanded uncertainty was 14 μg kg−1. The uncertainty budget was evaluated from sample in homogeneity, long-term and short-term stability and variability in the characterization procedure. GLHK-11-01a is primarily developed to support the local and wider testing community on need basis in quality assurance work and in seeking accreditation.

  7. Certified reference material IAEA-418: I-129 in Mediterranean sea water

    International Nuclear Information System (INIS)

    , production of reference materials and certified reference materials, and training. More than 40 reference materials have been produced, which include a wide range of marine sample matrices and radionuclide concentrations. As part of these activities, a new interlaboratory comparison was organized to provide the participating laboratories with the possibility to test the performance of their analytical methods for 129I on a Mediterranean sea water sample. The material was designed for the analysis of low level 129I in sea water. The sample, after successful certification, has been issued as a certified reference material for 129I in sea water. Laboratories were informed that, after the completion of the exercise, an IAEA report describing the results of the interlaboratory comparison would be issued, including their identities, but that the results would remain anonymous

  8. Assessment of commutability for candidate certified reference material ERM-BB130 "chloramphenicol in pork".

    Science.gov (United States)

    Zeleny, Reinhard; Emteborg, Håkan; Schimmel, Heinz

    2010-10-01

    Chloramphenicol (CAP), an effective antibiotic against many microorganisms, is meanwhile banned in the EU for treatment of food-producing animals due to adverse health effects. The Institute for Reference Materials and Measurements (IRMM) is currently developing a certified reference material (CRM) for CAP in pork, intended for validation and method performance verifications of analytical methods. The material will be certified using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) methods and has a target CAP level around the minimum required performance limit (MRPL) of 0.3 microg/kg. To prove that the material can be applied as a quality control tool for screening methods, a commutability study was conducted, involving five commercially available enzyme-linked immunosorbent assay kits and one biosensor assay (BiaCore kit). Meat homogenates (cryo-milled wet tissue) with CAP concentrations around the MRPL and the candidate CRM (lyophilised powder) were measured by LC-MS/MS and GC-MS as well as the six screening methods. Pairwise method comparisons of results obtained for the two sample types showed that the CRM can successfully be applied as quality control (QC) sample to all six screening methods. The study suggests that ERM-BB130 is sufficiently commutable with the investigated assays and that laboratories applying one of the investigated kits therefore benefit from using ERM-BB130 to demonstrate the correctness of their results. However, differences among the assays were observed, either in the abundance of bias between screening and confirmatory LC and GC methods, the repeatability of test results, or goodness of fit between the methods. PMID:20665007

  9. Development of Certified Reference Materials for Diarrhetic Shellfish Poisoning Toxins, Part 1: Calibration Solutions.

    Science.gov (United States)

    Beach, Daniel G; Crain, Sheila; Lewis, Nancy; LeBlanc, Patricia; Hardstaff, William R; Perez, Ruth A; Giddings, Sabrina D; Martinez-Farina, Camilo F; Stefanova, Roumiana; Burton, Ian W; Kilcoyne, Jane; Melanson, Jeremy E; Quilliam, Michael A; McCarron, Pearse

    2016-09-01

    Okadaic acid (OA) and its analogs dinophysistoxins-1 (DTX1) and -2 (DTX2) are lipophilic polyethers produced by marine dinoflagellates. These toxins accumulate in shellfish and cause diarrhetic shellfish poisoning (DSP) in humans. Regulatory testing of shellfish is essential to safeguard public health and for international trade. Certified reference materials (CRMs) play a key role in analytical monitoring programs. This paper presents an overview of the interdisciplinary work that went into the planning, production, and certification of calibration-solution CRMs for OA, DTX1, and DTX2. OA and DTX1 were isolated from large-scale algal cultures and DTX2 from naturally contaminated mussels. Toxins were isolated by a combination of extraction and chromatographic steps with processes adapted to suit the source and concentration of each toxin. New 19-epi-DSP toxin analogs were identified as minor impurities. Once OA, DTX1, and DTX2 were established to be of suitable purity, solutions were prepared and dispensed into flame-sealed glass ampoules. Certification measurements were carried out using quantitative NMR spectroscopy and LC-tandem MS. Traceability of measurements was established through certified external standards of established purity. Uncertainties were assigned following standards and guidelines from the International Organization for Standardization, with components from the measurement, stability, and homogeneity studies being propagated into final combined uncertainties. PMID:27524810

  10. Development of a certified reference material for genetically modified potato with altered starch composition.

    Science.gov (United States)

    Broothaerts, Wim; Corbisier, Philippe; Emons, Hendrik; Emteborg, Håkan; Linsinger, Thomas P J; Trapmann, Stefanie

    2007-06-13

    The presence of genetically modified organisms (GMOs) in food and feed products is subject to regulation in the European Union (EU) and elsewhere. As part of the EU authorization procedure for GMOs intended for food and feed use, reference materials must be produced for the quality control of measurements to quantify the GMOs. Certified reference materials (CRMs) are available for a range of herbicide- and insect-resistant genetically modified crops such as corn, soybean, and cotton. Here the development of the first CRM for a GMO that differs from its non-GMO counterpart in a major compositional constituent, that is, starch, is described. It is shown that the modification of the starch composition of potato (Solanum tuberosum L.) tubers, together with other characteristics of the delivered materials, have important consequences for the certification strategy. Moreover, the processing and characterization of the EH92-527-1 potato material required both new and modified procedures, different from those used routinely for CRMs produced from genetically modified seeds. PMID:17508757

  11. Toward the Development of Certified Reference Materials for Effective Biodiesel Testing - Part 1: Processing, Homogeneity, and Stability

    OpenAIRE

    ULBERTH-BUCHGRABER MANUELA; POTALIVO MONICA; EMTEBORG Per; HELD Andrea

    2011-01-01

    To address the current lack of certified reference materials (CRMs) for biodiesel analysis, the Institute for Reference Materials and Measurements (IRMM), Joint Research Centre (JRC), European Commission (EC), launched a comprehensive feasibility study on the production of biodiesel CRMs for relevant specification parameters as provided in EN 14214,1 the basis for defining product specifications and measurement methods for biodiesel in the European Union (EU). Laboratories need to be able to ...

  12. Development of certified matrix reference materials for quality assurance of screening 134Cs and 137Cs in food

    International Nuclear Information System (INIS)

    A certified reference material using activated alumina powder certified for activity of 134Cs and 137Cs was developed. The results of the verification and the certification are described. The certified reference material can be used for quality assurance of screening activity measurements of 134Cs and 137Cs in food/foodstuffs. Commercially available equipments were experimentally tested using the CRM and another CRM including 40K. The results of these tests are also shown. - Highlights: • CRM of 134Cs and 137Cs using activated alumina was developed. • CRM including 134Cs, 137Cs and 40K was also developed. • Results of experimental performance test of commercial inspection equipments using CRMs were shown

  13. Determination of multielements in a typical Japanese diet certified reference material by instrumental neutron activation analysis.

    Science.gov (United States)

    Suzuki, Shogo; Okada, Yukiko; Hirai, Shoji

    2003-08-01

    Multielements in a typical Japanese diet certified reference material prepared at the National Institute for Environmental Studies (NIES) of Japan, in collaboration with the National Institute of Radiological Sciences (NIRS) of Japan were determined by instrumental neutron activation analysis (INAA). Five samples (ca. 510-1000 mg) and comparative standards were irradiated for a short time (10 s) at a thermal neutron flux of 1.5 x 10(12) n cm(-2) s(-1) (pneumatic transfer) and for a long time (6 h) at a thermal neutron flux of 3.7 x 10(12) n cm(-2) s(-1) (central thimble) in the Rikkyo University Research Reactor (TRIGA Mark-II, 100 kW). The irradiated samples were measured by conventional gama-ray spectrometry using a coaxial Ge detector, and by anti-coincidence and coincidence gamma-ray spectrometry with a coaxial Ge detector and a well-type NaI(Tl) detector. The concentrations of 38 elements were determined by these methods. PMID:12945682

  14. Development of a new sodium diclofenac certified reference material using the mass balance approach and ¹H qNMR to determine the certified property value.

    Science.gov (United States)

    Nogueira, Raquel; Garrido, Bruno C; Borges, Ricardo M; Silva, Gisele E B; Queiroz, Suzane M; Cunha, Valnei S

    2013-02-14

    Certified reference materials (CRMs) are essential tools to guarantee the metrological traceability of measurement results to the International System of Units (SI), which means the accuracy and comparability of results over time and space. In the pharmaceutical area, only a few CRMs are available and the use of (non-certified) reference materials is a much more common practice. In this paper, the studies on a new candidate CRM of sodium diclofenac based on the ISO Guides 34:2009 and 35:2005 are described. The project steps included characterization, homogeneity test, stability studies, and uncertainties estimation. In the characterization, the mass fractions of organic, inorganic, and volatile impurities were determined, and the results were cross-checked by independent reference methods or interlaboratorial study. The API mass fraction was calculated by mass balance and cross-checked by quantitative proton nuclear magnetic resonance (¹H qNMR). The paper also presents a Monte Carlo simulation to estimate the measurement uncertainty as an approach to validate the GUM results in ¹H qNMR. The homogeneity between batch units was verified, and the candidate CRM stability under transport and storage conditions was evaluated in short- and long-term stability studies. The CRM certified property value and corresponding expanded uncertainty, obtained from the combined standard uncertainty multiplied by the coverage factor (k=2), for a confidence level of 95%, was (999.76+0.10) mg g⁻¹. PMID:23220339

  15. 235Uranium isotope abundance certified reference material for gamma spectrometry EC nuclear reference material 171 certification report

    International Nuclear Information System (INIS)

    This certification report contains the information necessary for the final certification of EC nuclear reference material 171. It is also intended to inform the user of the reference material concerned on technical/scientific details which are not given in the certificate. The report describes the reference material which consists of sets of U3O8 samples with five different 235U/U abundances, filled in cylindrical aluminium cans. The can bottom serves as window for emitted gamma radiation. The report describes how the 235U/U abundances were characterized, how the other properties relevant for gamma measurements were determined and gives all connected results as well as those from the verification measurements. Appendix A represents the draft certificate. 32 refs

  16. Development of a new ferulic acid certified reference material for use in clinical chemistry and pharmaceutical analysis

    Directory of Open Access Journals (Sweden)

    Dezhi Yang

    2015-05-01

    Full Text Available This study compares the results of three certified methods, namely differential scanning calorimetry (DSC, the mass balance (MB method and coulometric titrimetry (CT, in the purity assessment of ferulic acid certified reference material (CRM. Purity and expanded uncertainty as determined by the three methods were respectively 99.81%, 0.16%; 99.79%, 0.16%; and 99.81%, 0.26% with, in all cases, a coverage factor (k of 2 (P=95%. The purity results are consistent indicating that the combination of DSC, the MB method and CT provides a confident assessment of the purity of suitable CRMs like ferulic acid.

  17. DNA copy number concentration measured by digital and droplet digital quantitative PCR using certified reference materials.

    Science.gov (United States)

    Corbisier, Philippe; Pinheiro, Leonardo; Mazoua, Stéphane; Kortekaas, Anne-Marie; Chung, Pui Yan Jenny; Gerganova, Tsvetelina; Roebben, Gert; Emons, Hendrik; Emslie, Kerry

    2015-03-01

    The value assignment for properties of six certified reference materials (ERM-AD623a-f), each containing a plasmid DNA solution ranging from 1 million to 10 copies per μL, by using digital PCR (dPCR) with the BioMark™ HD System (Fluidigm) has been verified by applying droplet digital PCR (ddPCR) using the QX100 system (Bio-Rad). One of the critical factors in the measurement of copy number concentrations by digital PCR is the partition volume. Therefore, we determined the average droplet volume by optical microscopy, revealing an average droplet volume that is 8 % smaller than the droplet volume used as the defined parameter in the QuantaSoft software version 1.3.2.0 (Bio-Rad) to calculate the copy number concentration. This observation explains why copy number concentrations estimated with ddPCR and using an average droplet volume predefined in the QuantaSoft software were systematically lower than those measured by dPCR, creating a significant bias between the values obtained by these two techniques. The difference was not significant anymore when the measured droplet volume of 0.834 nL was used to estimate copy number concentrations. A new version of QuantaSoft software (version 1.6.6.0320), which has since been released with Bio-Rad's new QX200 systems and QX100 upgrades, uses a droplet volume of 0.85 nL as a defined parameter to calculate copy number concentration. PMID:25600685

  18. Development of a certified reference material: ethanol in water - a practical case

    Directory of Open Access Journals (Sweden)

    Vanderléa de Souza

    2006-01-01

    Full Text Available The present work describes the development of a certified reference material (CRM composed of solutions of ethanol in water in five different concentrations, and all stages necessary for the development of an CRM, according to the guidelines of ISO GUIDES 30, 31, 32, 33, 34 and 35. The development of this CRM has been determined by Inmetro Rule n. 006 of 2002, which requires that all breath alcohol analyzers being used in Brazil shall have their respective models approved and that the subsequent verifications shall be performed based on tests with solutions of ethanol in water. As a result, the development of this CRM significantly contributes to the reliability of measurements performed with breath alcohol analyzers, with stated measurement uncertainty. Equally important, this development provides society with a CRM that may have multiple applications, not restricted to the verification of breath alcohol analyzers.O presente trabalho descreve o desenvolvimento de um material de referência certificado (MRC referente a soluções de etanol em água em cinco concentrações diferentes, abordando todas as etapas necessárias para o desenvolvimento de um MRC, conforme prescreve as ISO GUIDE 30, 31, 32, 33, 34 e 35. O desenvolvimento deste MRC originou-se nas determinações da Portaria Inmetro n° 006 de 2002, que assegura que todos os etilômetros a serem utilizados no Brasil deverão ter os seus modelos aprovados, e as verificações realizadas a partir de ensaios com soluções de etanol em água. Após um treinamento, em fevereiro de 2003, no The Federal Institute for Material Research and Testing - BAM, que é um instituto metrológico alemão designado, a Dquim iniciou o processo de desenvolvimento deste MRC, o qual foi concluído em agosto de 2004. No Inmetro desenvolveu-se inicialmente o procedimento de preparo individual, onde as soluções do MRC são preparadas em garrafas de 0,5 L. Atualmente está se estudando, no Inmetro, o

  19. Preparation of zirconium and zirconium-base alloy certified reference materials JAERI-Z11 to -Z18

    International Nuclear Information System (INIS)

    The Second Sub-Committee on Zircaloy Analysis was organized in April, 1978, under the Committee on Analytical Chemistry on Nuclear Fuels and Reactor Materials, JAERI, for the renewal of zirconium and zirconium-base alloy certified reference materials ( CRM's). The Sub-Committee decided certified values of major constituents and impurities in eight reference materials ( JAERI -Z11 to -Z18 ) in July, 1983, based on the results obtained by cooperative analysis during 1978 to 1983. CRM's JAERI-Z11 to -Z14 are Zircaloy-2 in the form of disk, 32 mm in diameter and 20 mm in thickness, and useful primarily for fluorescent X-ray and emission spectrographic analysis. CRMs JAERI-Z15 and -Z16 are zirconium in the form of plate, 30 mm square and 2 mm in the thickness, and specially designed for the analysis of hafnium at trace levels : 2 to 40 μg/g. CRM's JAERI -Z17 and -Z18 are Zircaloy-2 and -4, respectively, in the form of chips, packed in a glass bottle of which content is 25 g and useful for the analysis of carbon in Zircaloy. This report describes mainly preparation of certified reference materials, and homogeneity test by neutron activation analysis and fluorescent X-ray spectrometry. CRMs JAERI-Z11 to -Z14 have been distributed with provisional certificate since July, 1979. (author)

  20. Development of a certified reference material for the content of nitroimidazole parent drugs and hydroxy metabolites in pork meat.

    Science.gov (United States)

    Zeleny, R; Schimmel, H; Ulberth, F; Emons, H

    2009-02-23

    Nitroimidazoles have been applied in the past to poultry and pigs to treat protozoan diseases and to combat bacterial infections, but due to adverse health effects their use in food-producing animals has meanwhile been banned in the EU. The request for a certified reference material in a representative matrix was stipulated by the responsible Community Reference Laboratory and is underpinned by the need to improve the accuracy and comparability of measurement data and to establish metrological traceability of analytical results. The Institute for Reference Materials and Measurements (IRMM) has responded to this demand by developing and producing a new certified matrix reference material, ERM-BB124. This incurred lyophilised pork meat material was certified according to ISO guides 34 and 35 for the mass fractions of six nitroimidazole compounds. Processing of the frozen muscle tissue to the final material was accomplished by application of cutting, freeze-drying, mixing and milling techniques. Homogeneity and stability measurements were performed using liquid chromatography tandem mass spectrometry. The relative standard uncertainty due to possible heterogeneity showed to be below 1.8% for all analytes. Potential degradation during transport and storage was assessed by isochronous stability studies. No significant instability was detected at a storage temperature of -20 degrees C for a shelf-life of 2 years. The certified mass fraction values were assigned upon evaluation of the data acquired in an international laboratory inter-comparison involving 12 expert laboratories using different sample preparation procedures, but exclusively LC-MS/MS methods. Relative standard uncertainty contributions for the characterisation (between-lab variation of mean values) were found to be between 1.6 and 4.8%. Certified values for five analytes were in the range of 0.7 to 6.2 microg kg(-1), with expanded relative uncertainties ranging between 7 and 14%. Dimetridazole could be

  1. Estimation of the minimum uncertainty of DNA concentration in a genetically modified maize sample candidate certified reference material.

    Science.gov (United States)

    Prokisch, J; Zeleny, R; Trapmann, S; Le Guern, L; Schimmel, H; Kramer, G N; Pauwels, J

    2001-08-01

    Homogeneity testing and the determination of minimum sample mass are an important part of the certification of reference materials. The smallest theoretically achievable uncertainty of certified concentration values is limited by the concentration distribution of analyte in the different particle size fractions of powdered biological samples. This might be of special importance if the reference material is prepared by dry mixing, a dilution technique which is used for the production of the new and third generation of genetically modified (GMO) plant certified reference materials. For the production of dry mixed PMON 810 maize reference material a computer program was developed to calculate the theoretically smallest uncertainty for a selected sample intake. This model was used to compare three differently milled maize samples, and the effect of dilution on the uncertainty of the DNA content of GMO maize was estimated as well. In the case of a 50-mg sample mass the lowest achievable standard deviation was 2% for the sample containing 0.1% GMO and the minimum deviation was less than 0.5% for the sample containing 5% GMO. PMID:11569879

  2. Certified reference materials for testing of the presence/absence of Staphylococcus aureus enterotoxin A (SEA) in cheese.

    Science.gov (United States)

    Zeleny, Reinhard; Nia, Yacine; Schimmel, Heinz; Mutel, Isabelle; Hennekinne, Jacques-Antoine; Emteborg, Håkan; Charoud-Got, Jean; Auvray, Frédéric

    2016-08-01

    Staphylococcal enterotoxins (SEs) account for a substantial number of food-poisoning outbreaks. European legislation (Commission Regulation 1441/2007) stipulates the reference procedure for SE analysis in milk and dairy products, which is based on extraction, dialysis concentration and immunochemical detection using one of two approved assays (VIDAS(®) SET2, Ridascreen(®) SET Total). However, certified reference materials (CRMs) are lacking to support laboratories in performing reliable detection of Staphylococcus aureus enterotoxin A (SEA) in relevant matrices at sub-nanogram per gram levels. The certification of a set of three reference materials (blank and two SEA-containing materials) for testing of the presence/absence of SEA in cheese is described. The reference procedure was applied in an intercomparison with 15 laboratories, and results were reported in a qualitative manner (presence or absence of SEA in the sample). No false-negative or false-positive results were obtained. The certified values were stated as diagnostic specificity (blank material) or diagnostic sensitivity (SEA-containing materials) and were 100 % in all cases. Stability studies demonstrated suitable material stability when stored cooled or frozen. An in-house study on the recovery of SEA in the cheese materials using a double-sandwich enzyme-linked immunosorbent assay (ELISA) revealed comparable recovery values of around 45 % at the two spiking levels and in both the SEA-containing CRMs as well as blank CRM freshly spiked prior to analysis. The values were also comparable over time and among different analysts. The materials provide valuable support to laboratories for method validation and method performance verification and will increase the reliability of measuring SEA in cheese. PMID:27220526

  3. A new certified reference material for benzene measurement in air on a sorbent tube: development and proficiency testing.

    Science.gov (United States)

    Caurant, A; Lalère, B; Schbath, M-C; Stumpf, C; Sutour, C; Mace, T; Quisefit, J-P; Doussin, J-F; Vaslin-Reimann, S

    2010-11-01

    A certified matrix reference material (CRM) for the measurement of benzene in ambient air has been developed at Laboratoire National de Métrologie et d'Essais. The production of these CRMs was conducted using a gravimetric method fully traceable to the International System of Units. The CRMs were prepared by sampling an accurate mass of a gaseous primary reference material of benzene, using a high-precision laminar flowmeter and a mass flow controller, with a PerkinElmer sampler filled with Carbopack™ X sorbent. The relative standard deviations obtained for the preparation of a batch of 20 tubes loaded with 500 ng of benzene were below 0.2%. Each CRM is considered independent from the others and with its own certified value and an expanded uncertainty estimated to be within 0.5%, lower than the uncertainties of benzene CRMs already available worldwide. The stability of these materials was also established up to 12 months. These CRMs were implemented during proficiency testing, to evaluate the analytical performances of seven French laboratories involved in benzene air monitoring.

  4. Determination of benzo[a]pyrene and dibenzopyrenes in a Chinese coal fly ash certified reference material.

    Science.gov (United States)

    Masala, Silvia; Bergvall, Christoffer; Westerholm, Roger

    2012-08-15

    Air pollution from coal combustion is of great concern in China because coal is the country's principal source of energy and it has been estimated that coal combustion is one of the main sources of polycyclic aromatic hydrocarbon (PAH) emissions in the nation. This study reports the concentrations of 15 PAHs including benzo[a]pyrene, dibenzo[a,l]pyrene, dibenzo[a,e]pyrene, dibenzo[a,i]pyrene and dibenzo[a,h]pyrene in a coal fly ash certified reference material (CRM) from China. To the best of our knowledge, dibenzo[a,l]pyrene, dibenzo[a,i]pyrene and dibenzo[a,h]pyrene concentrations in coal fly ash particles have not previously been reported. Benzo[a]pyrene is the only one of the studied hydrocarbons whose concentration in the coal fly ash CRM had previously been certified. The concentration of this species measured in this present work was twice the certified value. This is probably because of the exhaustive accelerated solvent extraction method employed. Consecutive extractions indicated an extraction recovery in excess of 95% for benzo[a]pyrene. For the other determined PAHs, repeat extractions indicated recoveries above 90%. PMID:22728296

  5. Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.

    Science.gov (United States)

    Kato, Megumi; Yamazaki, Taichi; Kato, Hisashi; Eyama, Sakae; Goto, Mari; Yoshioka, Mariko; Takatsu, Akiko

    2015-01-01

    To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purity certified reference materials (CRMs) for 17 proteinogenic amino acids. These CRMs are intended for use as primary reference materials to enable the traceable quantification of amino acids. The purity of the present CRMs was determined based on two traceable methods: nonaqueous acidimetric titration and nitrogen determination by the Kjeldahl method. Since neither method could distinguish compounds with similar structures, such as amino acid-related impurities, impurities were thoroughly quantified by combining several HPLC methods, and subtracted from the obtained purity of each method. The property value of each amino acid was calculated as a weighted mean of the corrected purities by the two methods. The uncertainty of the property value was obtained by combining measurement uncertainties of the two methods, a difference between the two methods, the uncertainty from the contribution of impurities, and the uncertainty derived from inhomogeneity. The uncertainty derived from instability was considered to be negligible based on stability monitoring of some CRMs. The certified value of each amino acid, property value with uncertainty, was given for both with or without enantiomeric separation.

  6. Certified reference, intercomparison, performance evaluation and emergency preparedness exercise materials for radionuclides in food

    International Nuclear Information System (INIS)

    The threat to global security from terrorist attack does not solely arise from illicit use of firearms, explosives or weapons of mass destruction. Terrorist threats will inevitably become more subtle as information and expertise is acquired by terrorist groups, and one vulnerable area is food and the food supply chain. Many laboratories, especially in countries with nuclear programmes, are involved in the routine monitoring of foodstuffs, and will be required to respond with increased food monitoring necessary for ensuring food safety and protecting public health after real (or perceived) contamination of food by either accidental or illicit means. This paper examines the needs for reference and performance testing materials that were identified at an international workshop to discuss this matter held at NIST in 2008, and further refined at a follow-up workshop in 2009. (author)

  7. Reference Materials

    Science.gov (United States)

    Merkus, Henk G.

    Reference materials for measurement of particle size and porosity may be used for calibration or qualification of instruments or for validation of operating procedures or operators. They cover a broad range of materials. On the one hand there are the certified reference materials, for which governmental institutes have certified one or more typical size or porosity values. Then, there is a large group of reference materials from commercial companies. And on the other hand there are typical products in a given line of industry, where size or porosity values come from the analysis laboratory itself or from some round-robin test in a group of industrial laboratories. Their regular application is essential for adequate quality control of particle size and porosity measurement, as required in e.g., ISO 17025 on quality management. In relation to this, some quality requirements for certification are presented.

  8. Determination of hexavalent chromium in plastic certified reference materials by X-ray absorption fine structure analysis

    Science.gov (United States)

    Ohata, Masaki; Matsubayashi, Nobuyuki

    X-ray absorption fine structure (XAFS) analysis with transmission mode was used to determine the percentages of hexavalent chromium {Cr(VI)} in total Cr in plastic certified reference materials (CRMs). Cr-K edge X-ray absorption near-edge structure (XANES) spectra were observed and the normalized pre-edge peaks of the spectrum where absorption data was summed was acquired for the determination of Cr(VI). Examination of different number of data point and range of photon energy for summed absorption of the pre-edge peak resulted in reproducible absorption data, though the measurements were carried out at different beam time and beam line. The concentrations of Cr(VI) in the plastic CRMs were also estimated from both the certified value of total Cr and the determined percentage of Cr(VI). The analytical procedure and the estimated concentrations can be useful for the determination of Cr(VI) in plastics with respect to RoHS (restriction of the use of hazardous substances in electrical and electronics equipment) directive.

  9. Determination of hexavalent chromium in plastic certified reference materials by X-ray absorption fine structure analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ohata, Masaki, E-mail: m-oohata@aist.go.jp [Inorganic Standard Section, Inorganic Analytical Chemistry Division, National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST) (Japan); Matsubayashi, Nobuyuki [Super-Spectroscopy System Research Group, Research Institute of Instrumentation Frontier (RIIF), National Institute of Advanced Industrial Science and Technology (AIST) (Japan)

    2014-03-01

    X-ray absorption fine structure (XAFS) analysis with transmission mode was used to determine the percentages of hexavalent chromium {Cr(VI)} in total Cr in plastic certified reference materials (CRMs). Cr-K edge X-ray absorption near-edge structure (XANES) spectra were observed and the normalized pre-edge peaks of the spectrum where absorption data was summed was acquired for the determination of Cr(VI). Examination of different number of data point and range of photon energy for summed absorption of the pre-edge peak resulted in reproducible absorption data, though the measurements were carried out at different beam time and beam line. The concentrations of Cr(VI) in the plastic CRMs were also estimated from both the certified value of total Cr and the determined percentage of Cr(VI). The analytical procedure and the estimated concentrations can be useful for the determination of Cr(VI) in plastics with respect to RoHS (restriction of the use of hazardous substances in electrical and electronics equipment) directive.

  10. Development of a certified reference material (NMIJ CRM 7512-a) for the determination of trace elements in milk powder.

    Science.gov (United States)

    Zhu, Yanbei; Narukawa, Tomohiro; Miyashita, Shin-ichi; Kuroiwa, Takayoshi; Inagaki, Kazumi; Chiba, Koichi; Hioki, Akiharu

    2013-01-01

    A certified reference material (CRM), NMIJ CRM 7512-a, was developed for the determination of trace elements in milk powder. At least three independent analytical methods were applied to characterize the certified value of each element; all of these analytical methods were based on microwave acid digestions and carried out using different analytical instruments. The certified value was given on a dry-mass basis, where the dry-mass correction factor was obtained by drying the sample at 65°C for 15 to 25 h. The certified values in the units of mass fractions for 13 elements were as follows: Ca, 8.65 (0.38) g kg(-1); Fe, 0.104 (0.007) g kg(-1); K, 8.41 (0.33) g kg(-1); Mg, 0.819 (0.024) g kg(-1); Na, 1.87 (0.09) g kg(-1); P, 5.62 (0.23) g kg(-1); Ba, 0.449 (0.013) mg kg(-1); Cu, 4.66 (0.23) mg kg(-1); Mn, 0.931 (0.032) mg kg(-1); Mo, 0.223 (0.012) mg kg(-1); Rb, 8.93 (0.31) mg kg(-1); Sr, 5.88 (0.20) mg kg(-1); and Zn, 41.3 (1.4) mg kg(-1), where the numbers in the parentheses are the expanded uncertainties with a coverage factor of 2. The expanded uncertainties were estimated considering the contribution of the analytical methods, the method-to-method variance, the sample homogeneity, the dry-mass correction factor, and the concentrations of the standard solutions for calibration. The concentrations of As (2.1 μg kg(-1)), Cd (0.2 μg kg(-1)), Cr (1.3 μg kg(-1)), Pb (0.3 μg kg(-1)), and Y (64 μg kg(-1)) were given as information values for the present CRM.

  11. Certified reference material for radionuclides in fish flesh sample IAEA-414 (mixed fish from the Irish Sea and North Sea)

    DEFF Research Database (Denmark)

    Pham, M.K.; Sanchez-Cabeza, J.A.; Povinec, P.P.;

    2006-01-01

    certified for this material. Information on massic activities with 95% confidence intervals is given for six other radionuclides (Sr-90, Pb-210(Po-210), Ra-226, Pu-239, Pu-240 Pu-241). Less frequently reported radionuclides (Tc-99, I-129, Th-228, Th-230 and Np-217) and information on some activity and mass...

  12. Validation of a liquid chromatographic method for determination of related substances in a candidate certified reference material of captopril

    Directory of Open Access Journals (Sweden)

    Raquel Nogueira

    2011-06-01

    Full Text Available This paper describes the validation of a reversed-phase high performance liquid chromatography method (RP-HPLC with diode array detection (DAD for determination of related substances (impurities from organic synthesis and degradation products of captopril according to the Brazilian Pharmacopeia IV. The aim of this study was to guarantee the method accuracy for quantification of related substances, an essential requisite to determine, using the mass balance approach, the captopril content in the first Brazilian certified reference material (CRM of an active pharmaceutical ingredient (API, developed by Inmetro. The captopril instability in solution is discussed and the captopril content determined by mass balance is compared to the results from titration and differential scanning calorimetry (DSC.Este artigo descreve a validação de método de cromatografia líquida de alta eficiência em fase reversa (CLAE-RP com detector de fotodiodos (DAD para determinação de substâncias relacionadas (impurezas orgânicas de síntese e produtos de degradação de captopril segundo Farmacopéia Brasileira IV ed. Este estudo teve como objetivo garantir que o método é capaz de quantificar com exatidão o teor de substâncias relacionadas, um requisito essencial para que o teor de captopril seja determinado por balanço de massa no primeiro material de referência certificado (MRC de fármacos brasileiro, o qual foi desenvolvido pelo Inmetro. A instabilidade do captopril em solução é discutida em detalhes e o teor de captopril determinado por balanço de massa é comparado com aqueles obtidos por titulação e por calorimetria exploratória diferencial (DSC.

  13. Impurity analyses of high-purity carbon monoxide gas using micro gas chromatography for development as a certified reference material.

    Science.gov (United States)

    Matsumoto, Nobuhiro; Watanabe, Takuro; Kato, Kenji

    2013-03-22

    High-purity carbon monoxide (CO) gas as a certified reference material (CRM) was analyzed using a micro gas chromatograph (micro-GC) with a micro thermal conductivity detector. The main reason to select the micro-GC was its compact size to provide a safe experimental environment. Thus, both the CO gas cylinder and the micro-GC were placed inside a draft shield with a limited small space. Peaks of several impurities were found in chromatograms of the micro-GC. The main impurities in the CO gas were helium, hydrogen, oxygen, nitrogen and carbon dioxide. It was found that helium was the impurity of the highest concentration. High-accuracy calibration gas mixtures were used to construct calibration lines for the micro-GC. The mixtures were precisely prepared by the gravimetric blending method. Calibration lines had enough linearity and accuracy for quantitative analyses of the impurities. The values of detection limit of the impurities were 0.7-4μmol/mol. The purity of the high-purity CO gas was around 99.996%, which was the value estimated from the sum of the concentrations of the impurities. PMID:23415447

  14. k0-INAA for APM samples collected in period of June 2004 - March 2005 and some marine certified reference materials

    International Nuclear Information System (INIS)

    The airborne particulate matter (APM) samples have been collected in 2004 using two types of polycarbonate membrane filter PM2.5 and PM2.5-10 at two sites of industrial (Ho Chi Mihn City) and rural (Dateh) regions in south of Vietnam. Three marine certified reference materials have been selected to establish a k0-NAA procedure for marine samples. The concentration of trace multi-element in the samples has been determined by the k0-INAA procedure using Ko-DALAT software developed in Dalat NRI. About 28 elements in 224 APM samples collected at two areas of Dateh and HCMC of Vietnam in period from June, 2004 to March, 2005 were presented in report. The statistical analysis was applied to the data set to investigate the pollution source at sampling sites. The results proved that the k0-NAA on the Dalat research reactor is a reliable and effective analytical technique for characterization of trace multi-element in APM and marine samples for air and marine environmental pollution study in Vietnam. (author)

  15. Feasibility study for the development of certified reference materials for specific migration testing. Part 1: Initial migrant concentration and specific migration

    NARCIS (Netherlands)

    Stoffers, N.H.; Störmer, A.; Bradley, E.L.; Brandsch, R.; Cooper, I.; Linssen, J.P.H.; Franz, R.

    2004-01-01

    The paper describes a project with the main objective of developing the know how to produce certified reference materials (CRMs) for specific migration testing. Certification parameters discussed are the initial concentration of the migrant in the polymer (C-P,C- 0) and the specific migration into a

  16. Preparation and certification of certified reference materials JAERI-Z21, Z22 and Z23 for analysis of zirconium and its alloys

    International Nuclear Information System (INIS)

    The Sub-Committee on Chemical Analysis of Nuclear Materials was organized in April 1987, under the Committee on Analytical Chemistry of Nuclear Fuels and Reactor Materials, JAERI, for renewal of certified reference materials of zirconium base alloys and zirconium metal. Collaborative analysis was carried out among ten participating laboratories for the certification of the JAERI CRMs Z21 to Z23. As a results of the collaborative works, the certified values for sixteen elements (Sn, Fe, Ni, Cr, Hf, Al, Si, Co, Cu, Ti, Mn, Pb, U, Cd, B and W) in the CRMs were given. In this report, preparation of raw materials, homogeneity test, chemical analysis for certification by collaborative works during April 1987 to March 1990 are described. (author)

  17. Development of SI-traceable C-peptide certified reference material NMIJ CRM 6901-a using isotope-dilution mass spectrometry-based amino acid analyses.

    Science.gov (United States)

    Kinumi, Tomoya; Goto, Mari; Eyama, Sakae; Kato, Megumi; Kasama, Takeshi; Takatsu, Akiko

    2012-07-01

    A certified reference material (CRM) is a higher-order calibration material used to enable a traceable analysis. This paper describes the development of a C-peptide CRM (NMIJ CRM 6901-a) by the National Metrology Institute of Japan using two independent methods for amino acid analysis based on isotope-dilution mass spectrometry. C-peptide is a 31-mer peptide that is utilized for the evaluation of β-cell function in the pancreas in clinical testing. This CRM is a lyophilized synthetic peptide having the human C-peptide sequence, and contains deamidated and pyroglutamylated forms of C-peptide. By adding water (1.00 ± 0.01) g into the vial containing the CRM, the C-peptide solution in 10 mM phosphate buffer saline (pH 6.6) is reconstituted. We assigned two certified values that represent the concentrations of total C-peptide (mixture of C-peptide, deamidated C-peptide, and pyroglutamylated C-peptide) and C-peptide. The certified concentration of total C-peptide was determined by two amino acid analyses using pre-column derivatization liquid chromatography-mass spectrometry and hydrophilic chromatography-mass spectrometry following acid hydrolysis. The certified concentration of C-peptide was determined by multiplying the concentration of total C-peptide by the ratio of the relative area of C-peptide to that of the total C-peptide measured by liquid chromatography. The certified value of C-peptide (80.7 ± 5.0) mg/L represents the concentration of the specific entity of C-peptide; on the other hand, the certified value of total C-peptide, (81.7 ± 5.1) mg/L can be used for analyses that does not differentiate deamidated and pyroglutamylated C-peptide from C-peptide itself, such as amino acid analyses and immunochemical assays.

  18. Certified Reference Materials for Radioactivity Measurements in Environmental Samples of Soil and Water: IAEA-444 and IAEA-445

    International Nuclear Information System (INIS)

    Reference Materials are an important requirement for any sort of quantitative chemical and radiochemical analysis. Laboratories need them for calibration and quality control throughout their analytical work. The IAEA started to produce reference materials in the early 1960's to meet the needs of the analytical laboratories in its Member States that required reference materials for quality control of their measurements. The initial efforts were focused on the preparation of environmental reference materials containing anthropogenic radionuclides for use by those laboratories employing nuclear analytical techniques. These reference materials were characterized for their radionuclide content through interlaboratory comparison involving a core group of some 10 to 20 specialist laboratories. The success of these early exercises led the IAEA to extend its activities to encompass both terrestrial and marine reference materials containing primordial radionuclides and trace elements. Within the frame of IAEA activities in production and certification of reference materials, this report describes the certification of the IAEA-444 and IAEA-445: soil and water spiked with gamma emitting radionuclides respectively. Details are given on methodologies and data evaluation

  19. Electrothermal atomic absorption spectrometric determination of vanadium in extracts of soil and sewage sludge certified reference materials after fractionation by means of the Communities Bureau of Reference modified sequential extraction procedure

    International Nuclear Information System (INIS)

    A modified three-step sequential extraction procedure proposed by the Commission of European Communities Bureau of Reference (BCR) was applied to certified reference materials of three different soil groups (rendzina, luvisol, cambisol) and sewage sludge of different composition originating from a municipal water treatment plant in order to assess potential mobility and the distribution of vanadium in the resulting fractions. Analysis of the extracts was carried out by electrothermal atomic absorption spectrometry with Zeeman background correction using transversely heated graphite atomizers. Extracts showed significant matrix interferences which were overcome by the standard addition technique. The original soil and sludge certified reference materials (CRMs) and the extraction residue from the sequential extraction were decomposed by a mixture of HNO3-HClO4-HF in an open system. The content of V determined after decomposition of the samples was in very good agreement with the certified total values. The accuracy of the sequential extraction procedure was checked by comparing the sum of the vanadium contents in the three fractions and in the extraction residue with the certified total content of V. The amounts of vanadium leached were in good correlation with the certified total contents of V in the CRMs of soils and sewage sludge. In the soils examined, vanadium was present almost entirely in the mineral lattice, while in the sewage sludge samples 9-14% was found in the oxidizable and almost 25% in the reducible fractions. The recovery ranged from 93-106% and the precision (RSD) was below 10%

  20. Feasibility study for the development of certified reference materials for specific migration testing. Part 1: initial migrant concentration and specific migration.

    Science.gov (United States)

    Stoffers, N H; Störmer, A; Bradley, E L; Brandsch, R; Cooper, I; Linssen, J P H; Franz, R

    2004-12-01

    The paper describes a project with the main objective of developing the know how to produce certified reference materials (CRMs) for specific migration testing. Certification parameters discussed are the initial concentration of the migrant in the polymer (C(P),0) and the specific migration into a food simulant under certain temperature/time conditions. Sixteen preliminary candidate CRMs were defined and produced. The most important polymers (low- and high-density polyethylene (LDPE and HDPE), polypropylene (PP), polystyrene (PS), polyethylene terephtalate (PET), plasticized polyvinyl chloride (PVC), rigid PVC, polyamides (PA)) and additives as well as monomers representing different physicochemical properties as target substances for migration were chosen. The stability and homogeneity of the migrants in the materials were tested and methods for the determination of the certification parameters were developed and validated. > From the 16 materials produced, the six most suitable CRM candidates (LDPE//Irganox 1076/Irgafos 168, LDPE//1,4-diphenyl-1,3-butadiene (DPBD), HDPE//Chimassorb 81/Uvitex OB, PP homo//Irganox 1076/Irgafos 168, HIPS, 1% mineral oil//styrene, PA 6//caprolactam) were selected. The feasibility of CRM production for the six candidate materials was demonstrated and a trial certification exercise was performed with participation of all four partner laboratories. All six materials showed suitable properties for future production as certified reference materials. PMID:15799565

  1. Determination of the carbon, hydrogen and nitrogen contents of alanine and their uncertainties using the certified reference material L-alanine (NMIJ CRM 6011-a).

    Science.gov (United States)

    Itoh, Nobuyasu; Sato, Ayako; Yamazaki, Taichi; Numata, Masahiko; Takatsu, Akiko

    2013-01-01

    The carbon, hydrogen, and nitrogen (CHN) contents of alanine and their uncertainties were estimated using a CHN analyzer and the certified reference material (CRM) L-alanine. The CHN contents and their uncertainties, as measured using the single-point calibration method, were 40.36 ± 0.20% for C, 7.86 ± 0.13% for H, and 15.66 ± 0.09% for N; the results obtained using the bracket calibration method were also comparable. The method described in this study is reasonable, convenient, and meets the general requirement of having uncertainties ≤ 0.4%.

  2. The validation of Kayzero-assisted NAA in Budapest, Rez, and Ljubljana via the analysis of three BCR certified reference materials.

    Science.gov (United States)

    De Corte, F; van Sluijs, R; Simonits, A; Kucera, J; Smodis, B; Byrne, A R; De Wispelaere, A; Bossus, D; Frána, J; Horák, Z; Jaćimović, R

    2001-05-01

    After installation and calibration of k0-assisted NAA in three Central European research institutes (AEKI-Budapest, NPI-Rez, and IJS, Ljubljana), its validation was established via the analysis of three BCR certified reference materials. The matrices of choice were: CRM 277 estuarine sediment, CRM 038 coal fly ash from pulverized coal, and CRM 101 spruce needles. For some elements, e.g. Zn, Cd, and Hg, the analyses were not only performed instrumentally (INAA), but also in the radiochemical mode (RNAA). The work was performed in the framework of a European Copernicus Project. PMID:11393234

  3. Thermal desorption GC-MS as a tool to provide PAH certified standard reference material on particulate matter quartz filters.

    Science.gov (United States)

    Grandesso, Emanuela; Pérez Ballesta, Pascual; Kowalewski, Konrad

    2013-02-15

    Reference materials for particulate matter (PM) on filter media are not available for the quantification of polycyclic aromatic hydrocarbons (PAHs) in ambient air. This is due to the difficulty of obtaining reference material that has a homogeneous distribution on a filter surface that is large enough for characterization and distribution. High volume sample filters from different locations and seasons were considered to validate the feasibility of the use of quartz filters as reference material for PAH concentrations. A rapid thermal desorption (TD) technique coupled with gas chromatography/mass spectroscopy was applied to characterise the material for the content of fifteen different PAHs. TD technique allowed for rapid and accurate analysis of small sections of filter (5mm diameter), leaving enough material for the production of twenty sub-filter cuts (42 mm diameter) that could be used for distribution and control. Stability and homogeneity tests required for material certification were performed as indicated by the ISO guide 34:2009 and ISO 35:2006. The contribution of the heterogeneous distribution of PAHs on the filter surface resulted generally lower than 10% and higher for more volatile PAHs. One year of storage at -18°C indicated no significant variation in PAH concentrations. Nevertheless, a methodology for shipping and storing of the filter material at ambient temperature in especially designed plastic envelopes, was also shown to allow for stabile concentrations within twenty days. The method accuracy was confirmed by the analysis of NIST SRM 1649a (urban dust) and PAH concentrations were validated against the reference values obtained from an inter-laboratory exercise. In the case of benzo[a]pyrene for masses quantified between 100 pg and 10 ng the TD method provided expanded uncertainties of circa 10%, while the inter-laboratory reference value uncertainties ranged between 15 and 20%. The evaluation of these results supports the use of the presented

  4. Development of C-reactive protein certified reference material NMIJ CRM 6201-b: optimization of a hydrolysis process to improve the accuracy of amino acid analysis.

    Science.gov (United States)

    Kato, Megumi; Kinumi, Tomoya; Yoshioka, Mariko; Goto, Mari; Fujii, Shin-Ichiro; Takatsu, Akiko

    2015-04-01

    To standardize C-reactive protein (CRP) assays, the National Metrology Institute of Japan (NMIJ) has developed a C-reactive protein solution certified reference material, CRM 6201-b, which is intended for use as a primary reference material to enable the SI-traceable measurement of CRP. This study describes the development process of CRM 6201-b. As a candidate material of the CRM, recombinant human CRP solution was selected because of its higher purity and homogeneity than the purified material from human serum. Gel filtration chromatography was used to examine the homogeneity and stability of the present CRM. The total protein concentration of CRP in the present CRM was determined by amino acid analysis coupled to isotope-dilution mass spectrometry (IDMS-AAA). To improve the accuracy of IDMS-AAA, we optimized the hydrolysis process by examining the effect of parameters such as the volume of protein samples taken for hydrolysis, the procedure of sample preparation prior to the hydrolysis, hydrolysis temperature, and hydrolysis time. Under optimized conditions, we conducted two independent approaches in which the following independent hydrolysis and liquid chromatography-isotope dilution mass spectrometry (LC-IDMS) were combined: one was vapor-phase acid hydrolysis (130 °C, 24 h) and hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) method, and the other was microwave-assisted liquid-phase acid hydrolysis (150 °C, 3 h) and pre-column derivatization liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The quantitative values of the two different amino acid analyses were in agreement within their uncertainties. The certified value was the weighted mean of the results of the two methods. Uncertainties from the value-assignment method, between-method variance, homogeneity, long-term stability, and short-term stability were taken into account in evaluating the uncertainty for a certified value. The certified value and the

  5. Effect of certified reference material 470 (CRM 470) on national quality assurance programs for serum proteins in Europe.

    Science.gov (United States)

    Johnson, A M; Whicher, J T

    2001-11-01

    The introduction of the international reference material for serum proteins, CRM 470, has resulted in significant reduction of the among-laboratory variance for most proteins assayed in European national quality assurance programs. In general, the CVs have decreased by 5 to 65%. However, both among- and within-manufacturer variances in many cases remain unacceptably high. In addition, concentration-dependent differences in variance and bias are present for some proteins. Although some variance will persist, reducing variance and bias to levels required for the institution of universal reference ranges will necessitate more accurate transfer of values to calibrants and controls and improved calibration curve fitting by manufacturers, as well as better quality control within laboratories.

  6. Comparative study of optimised BCR sequential extraction scheme and acid leaching of elements in the certified reference material NIST 2711

    International Nuclear Information System (INIS)

    The optimised BCR sequential extraction procedure and a 4 h 1 mol L-1 HCl partial extraction have been performed on the NIST 2711 reference material for a suite of 12 elements (Cd, Sb, Pb, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As) using magnetic sector ICP-MS. A pseudo-total aqua regia digest of NIST 2711 has also been undertaken for quality assurance purposes, and comparison of the sum of the four BCR fractions, which included an aqua regia digest on the residue, with the pseudo-total aqua regia digest has been used to assess the accuracy of the BCR partitioning approach. As a result of this work, discrepancies between previous studies about BCR partitioning of elements in NIST 2711 have been discussed and an increase in confidence about the use of BCR partitioning scheme on seven elements (Cd, Pb, Al, Mn, Fe, Cu, Zn) in this standard material has been obtained. On the other hand, BCR partitioning for Sb, Cr, Co, Ni and As has been provided for the first time. Partial extraction results are also reported for the same 12 elements analysed by the optimised BCR procedure, with the partial extraction results exhibiting a strong correlation with the sum of the three labile steps of the BCR procedure

  7. Quantitative Analysis of Plutonium Content in Particles Collected from a Certified Reference Material by Total Nuclear Reaction Energy (Q Value) Spectroscopy

    Science.gov (United States)

    Croce, M. P.; Hoover, A. S.; Rabin, M. W.; Bond, E. M.; Wolfsberg, L. E.; Schmidt, D. R.; Ullom, J. N.

    2016-08-01

    Microcalorimeters with embedded radioisotopes are an emerging category of sensor with advantages over existing methods for isotopic analysis of trace-level nuclear materials. For each nuclear decay, the energy of all decay products captured by the absorber (alpha particles, gamma rays, X-rays, electrons, daughter nuclei, etc.) is measured in one pulse. For alpha-decaying isotopes, this gives a measurement of the total nuclear reaction energy (Q value) and the spectra consist of well-separated, narrow peaks. We have demonstrated a simple mechanical alloying process to create an absorber structure consisting of a gold matrix with small inclusions of a radioactive sample. This absorber structure provides an optimized energy thermalization environment, resulting in high-resolution spectra with minimal tailing. We have applied this process to the analysis of particles collected from the surface of a plutonium metal certified reference material (CRM-126A from New Brunswick Laboratory) and demonstrated isotopic analysis by microcalorimeter Q value spectroscopy. Energy resolution from the Gaussian component of a Bortels function fit was 1.3 keV FWHM at 5244 keV. The collected particles were integrated directly into the detector absorber without any chemical processing. The ^{238}Pu/^{239}Pu and ^{240}Pu/^{239}Pu mass ratios were measured and the results confirmed against the certificate of analysis for the reference material. We also demonstrated inter-element analysis capability by measuring the ^{241}Am/^{239}Pu mass ratio.

  8. Quantitative Analysis of Plutonium Content in Particles Collected from a Certified Reference Material by Total Nuclear Reaction Energy (Q Value) Spectroscopy

    Science.gov (United States)

    Croce, M. P.; Hoover, A. S.; Rabin, M. W.; Bond, E. M.; Wolfsberg, L. E.; Schmidt, D. R.; Ullom, J. N.

    2016-03-01

    Microcalorimeters with embedded radioisotopes are an emerging category of sensor with advantages over existing methods for isotopic analysis of trace-level nuclear materials. For each nuclear decay, the energy of all decay products captured by the absorber (alpha particles, gamma rays, X-rays, electrons, daughter nuclei, etc.) is measured in one pulse. For alpha-decaying isotopes, this gives a measurement of the total nuclear reaction energy (Q value) and the spectra consist of well-separated, narrow peaks. We have demonstrated a simple mechanical alloying process to create an absorber structure consisting of a gold matrix with small inclusions of a radioactive sample. This absorber structure provides an optimized energy thermalization environment, resulting in high-resolution spectra with minimal tailing. We have applied this process to the analysis of particles collected from the surface of a plutonium metal certified reference material (CRM-126A from New Brunswick Laboratory) and demonstrated isotopic analysis by microcalorimeter Q value spectroscopy. Energy resolution from the Gaussian component of a Bortels function fit was 1.3 keV FWHM at 5244 keV. The collected particles were integrated directly into the detector absorber without any chemical processing. The ^{238} Pu/^{239} Pu and ^{240} Pu/^{239} Pu mass ratios were measured and the results confirmed against the certificate of analysis for the reference material. We also demonstrated inter-element analysis capability by measuring the ^{241} Am/^{239} Pu mass ratio.

  9. The Kjeldahl method as a primary reference procedure for total protein in certified reference materials used in clinical chemistry. I. A review of Kjeldahl methods adopted by laboratory medicine.

    Science.gov (United States)

    Chromý, Vratislav; Vinklárková, Bára; Šprongl, Luděk; Bittová, Miroslava

    2015-01-01

    We found previously that albumin-calibrated total protein in certified reference materials causes unacceptable positive bias in analysis of human sera. The simplest way to cure this defect is the use of human-based serum/plasma standards calibrated by the Kjeldahl method. Such standards, commutative with serum samples, will compensate for bias caused by lipids and bilirubin in most human sera. To find a suitable primary reference procedure for total protein in reference materials, we reviewed Kjeldahl methods adopted by laboratory medicine. We found two methods recommended for total protein in human samples: an indirect analysis based on total Kjeldahl nitrogen corrected for its nonprotein nitrogen and a direct analysis made on isolated protein precipitates. The methods found will be assessed in a subsequent article.

  10. Development of a Certified Reference Material for Lyophilized Vitamin K 1%维生素 K1冻干标准物质的研制

    Institute of Scientific and Technical Information of China (English)

    张晓光; 黄挺; 张伟; 黄亮; 全灿; 李红梅; 杨屹

    2015-01-01

    采用二甲基亚砜(DMSO)作为冻干标准物质的溶剂,以重量法准确配制维生素 K1/ DMSO 溶液,再进行分装、冷冻干燥,经定性分析、定值分析、均匀性检验、稳定性考察和不确定度评定,研制了维生素 K1冻干标准物质。以维生素 K1纯度标准物质溶液为校准品,对得到的冻干物质进行了高效液相色谱法定值分析,冻干标准物质的准确定值结果为0.96 mg/ mL,相对扩展不确定度为7%。建立的维生素 K1冻干标准物质研制方法,对于临床检验中维生素 K1的准确测定和相关疾病的正确诊断治疗以及维生素 K1长期保存具有重要意义。%Dimethyl sulfone( DMSO)is firstly applied as the solvent for a lyophilized certified reference material (CRM). Vitamin K1 / DMSO solution is prepared by gravimetry,and is sub-divided and lyophilized,the lyophilized vitamin K1 CRM is developed through qualitative analysis,quantitative analysis,homogeneity study,stability study and uncertainty evaluation. Certified value of lyophilization vitamin K1 is analyzed by high performance liquid chromatography method, using the vitamin K1 purity CRM as a calibrant. The certified value is 0. 96 mg/ mL,with the relative expanded uncertainty of 7% . The method of CRM lyophilized vitamin K1 makes great significance for the accurate determination the disease in clinical examination and the long-term preservation of vitamin K1 .

  11. Characterization and Uncertainty Assessment of a Certified Reference Material of Chloramphenicol in Methanol (GBW(E)082557).

    Science.gov (United States)

    Yang, Mengrui; Wang, Min; Zhou, Jian; Song, Yinqing; Wang, Tongtong

    2016-01-01

    Prior to preparation of CRM candidate of chloramphenicol in methanol with a concentration of 100 mg/L, two independent methods including mass balance (MB) and quantitative nuclear magnetic resonance (qNMR) were employed to precisely measure the mass fraction of pure chloramphenicol materials. The mass fraction was assigned to be 99.8% with uncertainty of 0.3%. Homogeneity testing and stability study of chloramphenicol in methanol were examined by using high performance liquid chromatography. Additionally, the uncertainties originating from the process of CRM development were comprehensively evaluated. The experimental results indicate that the property value of this CRM is homogeneous and stable at 4°C for at least six months. The new CRM (GBW(E)082557) can be applicable to calibration of instrument and assurance of accuracy and comparability of results in routine measurement. PMID:27493666

  12. Characterization and Uncertainty Assessment of a Certified Reference Material of Chloramphenicol in Methanol (GBW(E)082557)

    Science.gov (United States)

    Zhou, Jian; Song, Yinqing; Wang, Tongtong

    2016-01-01

    Prior to preparation of CRM candidate of chloramphenicol in methanol with a concentration of 100 mg/L, two independent methods including mass balance (MB) and quantitative nuclear magnetic resonance (qNMR) were employed to precisely measure the mass fraction of pure chloramphenicol materials. The mass fraction was assigned to be 99.8% with uncertainty of 0.3%. Homogeneity testing and stability study of chloramphenicol in methanol were examined by using high performance liquid chromatography. Additionally, the uncertainties originating from the process of CRM development were comprehensively evaluated. The experimental results indicate that the property value of this CRM is homogeneous and stable at 4°C for at least six months. The new CRM (GBW(E)082557) can be applicable to calibration of instrument and assurance of accuracy and comparability of results in routine measurement. PMID:27493666

  13. Characterization and Uncertainty Assessment of a Certified Reference Material of Chloramphenicol in Methanol (GBW(E)082557).

    Science.gov (United States)

    Yang, Mengrui; Wang, Min; Zhou, Jian; Song, Yinqing; Wang, Tongtong

    2016-01-01

    Prior to preparation of CRM candidate of chloramphenicol in methanol with a concentration of 100 mg/L, two independent methods including mass balance (MB) and quantitative nuclear magnetic resonance (qNMR) were employed to precisely measure the mass fraction of pure chloramphenicol materials. The mass fraction was assigned to be 99.8% with uncertainty of 0.3%. Homogeneity testing and stability study of chloramphenicol in methanol were examined by using high performance liquid chromatography. Additionally, the uncertainties originating from the process of CRM development were comprehensively evaluated. The experimental results indicate that the property value of this CRM is homogeneous and stable at 4°C for at least six months. The new CRM (GBW(E)082557) can be applicable to calibration of instrument and assurance of accuracy and comparability of results in routine measurement.

  14. A certified urea reference material (NMIJ CRM 6006-a) as a reliable calibrant for the elemental analyses of amino acids and food samples.

    Science.gov (United States)

    Itoh, Nobuyasu; Yamazaki, Taichi; Sato, Ayako; Numata, Masahiko; Takatsu, Akiko

    2014-01-01

    We examined the reliability of a certified reference material (CRM) for urea (NMIJ CRM 6006-a) as a calibrant for N, C, and H in elemental analyzers. Only the N content for this CRM is provided as an indicative value. To estimate the C and H contents of the urea CRM, we took into account the purity of the urea and the presence of other identified impurities. When we examined the use of various masses of the calibrant (0.2 to 2 mg), we unexpectedly observed low signal intensities for small masses of H and N, but these plateaued at about 2 mg. We therefore analyzed four amino acid CRMs and four food CRMs on a 2-mg scale with the urea CRM as the calibrant. For the amino acid CRMs, the differences in the analytical and theoretical contents (≤0.0026 kg/kg) were acceptable with good repeatability (≤0.0013 kg/kg in standard deviation; n = 4). For food CRMs, comparable repeatabilities to those obtained with amino acid CRMs (≤0.0025 kg/kg in standard deviation; n = 4) were obtained. The urea CRM can therefore be used as a reliable calibrant for C, H, and N in an elemental analyzer.

  15. 法医DNA标准物质STR位点等位基因分型定值研究%Certified value study for alleles on STR loci of forensic DNA reference materials

    Institute of Scientific and Technical Information of China (English)

    赵兴春; 孙敬; 印佳; 王燕; 姜伯玮; 高运华; 叶健

    2012-01-01

    为探讨法医DNA标准物质STR位点等位基因分型的定值和溯源,利用有机法提取法医DNA标准物质备选所用细胞基因组DNA,以其为模板进行STR复合扩增,制备获得等位基因分型片段并测序分析,成功获得法医DNA标准物质备选所用细胞STR位点等位基因分型的定值.对STR位点等位基因分型进行定值研究可以作为法医DNA标准物质溯源研究的有效途径之一.%In order to develop the certified value and traceability for the alleles on STR loci of forensic DNA reference materials, the genomic DNA of the cells was extracted and amplified for preparing the forensic DNA reference materials. Then the allelic DNA was prepared, sequenced and valuated. Finally the value for the alleles on STR loci of the cells was certified. The certified value for the alleles on STR loci can work as an effective approach for the traceability of forensic DNA reference materials.

  16. 冻干人尿中汞成分分析标准物质的研制%Development of the certified reference material of mercury in lyophilized human urine

    Institute of Scientific and Technical Information of China (English)

    赵玮; 张福钢; 李春伶; 杜会芳; 潘亚娟; 张敬; 闫慧芳

    2011-01-01

    Objective To develop the certified reference material of mercury in lyophilized human urine. Methods Human urine samples from normal level mercury districts were filtered, homogenized,dispensed, lyophilized and radio-sterilized. Homogeneity test, stability inspection and certification were conducted using a atom fluorescence spectrophotometric method. The physical and chemical stability of the certified reference material were assessed for 18 months. The certified values are based on analysis made by three independent laboratories. Results The certified values are as follows: low level was (35.6±2.1)μg/L,high level was (50.5±3.0) μg/l. Conclusion The certified reference material of mercury in lyophilized human urine in this research reached the national certified reference material requirements and could be used for the quality control.%目的 研制冻干人尿中汞成分分析标准物质.方法 冻干尿由正常人尿经过滤、加标、混匀、分装、冷冻干燥、辐射灭菌制备而成,使用原子荧光测定方法 对其均匀性和稳定性进行检验,由3家实验室用准确可靠的方法 确定标准值,并对尿中汞研制物的不确定度进行分析.结果 本研制物均匀性良好,-20 ℃保存可稳定18个月,2个水平的量值及不确定度分别为(35.6±2.1)和(50.5±3.0)μg/L.结论 尿中汞成分分析标准物质各项指标符合的要求,可用于实验室检测的质量控制.

  17. Development of Certified Reference Material of Wheat Powder for Analysis of Nutritional Ingredients%小麦粉营养成分分析标准物质的研制

    Institute of Scientific and Technical Information of China (English)

    蒋子刚; 应劼; 顾金炎; 张保国; 张伟萍; 陆慧

    2000-01-01

    A certified reference material of wheat powder for the analysis of twenty nutritional ingredients was prepared by means of peeling, crushing and sifting the wheat seed ″ Yang Mai No 1″, cultivated by Crop Institute of Shanghai Academy of Agricultural Science. The stabile period of the certified reference material is more than seven years after it was irradiated by 60Co γ _ ray. Its homogeneity is good according to F _ test and t _ test. The twenty nutritional ingredients include crude protein, crude starch, crude fat, total amino acid, and individual amino acid: aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, lysine, histidine and arginine. Its stability, homogeneity and uncertainty of definite values for the nutritional ingredients fit the technological requirements of certified reference material. Its qualification of GBW has been approved.%进行了小麦粉营养成分分析标准物质的研制。选用上海农业科学院作物研究所培育的“杨麦一号”小麦种子经脱壳、粉碎、过筛,用60Co γ射线照射使其贮存稳定期达7年以上;用数理统计F检验法和t检验法检验证明其均匀性良好;由9个单位共同协作定值,共定值137组, 548个数据,经统计检验,小麦粉中粗蛋白质、粗淀粉、粗脂肪、氨基酸总量、天门冬氨酸、苏氨酸、丝氨酸、谷氨酸、脯氨酸、甘氨酸、丙氨酸、缬氨酸、蛋氨酸、异亮氨酸、亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、组氨酸、精氨酸共20个营养成分定为标准值。所研制的标准物质其稳定性、均匀性及营养成分定值的不确定度均符合国家级标准物质技术指标,已被批准为国家级标准物质。

  18. The Kjeldahl method as a primary reference procedure for total protein in certified reference materials used in clinical chemistry. II. Selection of direct Kjeldahl analysis and its preliminary performance parameters.

    Science.gov (United States)

    Vinklárková, Bára; Chromý, Vratislav; Šprongl, Luděk; Bittová, Miroslava; Rikanová, Milena; Ohnútková, Ivana; Žaludová, Lenka

    2015-01-01

    To select a Kjeldahl procedure suitable for the determination of total protein in reference materials used in laboratory medicine, we reviewed in our previous article Kjeldahl methods adopted by clinical chemistry and found an indirect two-step analysis by total Kjeldahl nitrogen corrected for its nonprotein nitrogen and a direct analysis made on isolated protein precipitates. In this article, we compare both procedures on various reference materials. An indirect Kjeldahl method gave falsely lower results than a direct analysis. Preliminary performance parameters qualify the direct Kjeldahl analysis as a suitable primary reference procedure for the certification of total protein in reference laboratories.

  19. Determination of rare earth and uranium in reference biological materials certified by the method of neutron activation analysis; Determinacao de terras raras e de uranio em materiais biologicos de referencia certificados pelo metodo de analise por ativacao com neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Lais H.P.; Saiki, Mitiko, E-mail: laispaciulli@gmail.com, E-mail: mitiko@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    The objective of this study was to evaluate the precision and accuracy of the determinations of Sc, La, Ce, Nd, Sm, Eu, Tb, Yb, Lu and U in certified reference materials (CRMs). To solve the problem of interference from fission products of U in the determination of lanthanides were obtained correction factors for this interference for {sup 140}La, {sup 141}Ce, {sup 143}Ce, {sup 153}Sm and {sup 147}Nd. The experimental procedure of Neutron Activation Analysis consisted of irradiating aliquots of each of the CRMs with synthetic standards of elements under thermal neutron flux of the IEA-R1 nuclear reactor, followed by gamma-ray spectrometry using a high-resolution hyperpurity GE detector. The analyzes of CRMs indicate good accuracy and precision of results, demonstrating the feasibility of applying of established procedure in NAA of elements studied in organic vegetable matrices.

  20. Preparation of the Certified Reference Material of Potassium Permanganate Solution%高锰酸钾溶液标准物质的研制

    Institute of Scientific and Technical Information of China (English)

    梁秀丽; 张坤; 王爱萍; 李本涛; 王学琴; 姚旭霞; 刘立君

    2013-01-01

    Preparation process of potassium permanganate solution standard material was introduced. Weighing titrimetric method was used for certification. The homogeneity and stability of potassium permanganate solution standard material were examined. The results indicated that the standard material was homogeneous and the value stated was valid for a period of 6 month. The stated value of it was c( 1 / 5 KMnO4)=0.100 7 mol / kg(k=2). The standard material meets the requirements of the secondary level of standard material and it has been authorized for the state-level standard material.%介绍高猛酸钾溶液标准物质的研制过程.对研制的溶液标准物质进行了均匀性和稳定性考察.结果表明,该标准物质均匀性良好,定值稳定期为6个月.用称量滴定法定值,定值结果为c(1/5KMnO4)=0.1007 mol/kg(k=2).该标准溶液满足二级标准物质的技术要求,已被批准为国家级二级标准物质.

  1. Preparação de um material de referência certificado para controle de agrotóxicos em hortifrutigranjeiros: estudo da homogeneidade Preparation of a certified reference material for pesticide control in the cultivation of fruits and vegetables: a homogeneity study

    Directory of Open Access Journals (Sweden)

    Maria Helena Wohlers Morelli Cardoso

    2010-06-01

    Full Text Available Neste trabalho são apresentados os esforços para garantir a homogeneidade de um material de referência. Níveis residuais (mg.kg-1 de quatro agrotóxicos (γ-HCH, fenitrotiona, clorpirifós e procimidona foram adicionados à polpa de tomate com o objetivo de se preparar um material de referência certificado. As propriedades mais importantes desses materiais são a homogeneidade e a estabilidade. Antes de serem enviados a outros laboratórios, os materiais de referência precisam ter sua homogeneidade verificada. Nas etapas prévias, amostras foram avaliadas de modo a prover dados sobre o tratamento mais adequado para minimizar a variabilidade analítica do lote preparado e garantir a qualidade da amostra candidata a material de referência certificado, tão bem como a estimativa da incerteza associada à homogeneidade. A análise de variância fornece informações sobre a variabilidade do lote preparado e o grau de invariabilidade da amostra fortificada. Depois da preparação, as amostras foram expostas à radiação gama na dose de 2 kGy e submetidas a um estudo interlaboratorial para certificação. As concentrações certificadas dos agrotóxicos após caracterização foram 0,191 ± 0,047 mg.kg-1; 0,192 ± 0,068 mg.kg-1; 0,225 ± 0,076 mg.kg-1e 0,177 ± 0,051 mg.kg-1 para o γ-HCH, a fenitrotiona, clorpirifós e procimidona respectivamente.This study reports on the efforts to ensure homogeneity of certified reference materials. Residues of four pesticides (γ-HCH, fenitrothion, chlorpyrifos, and procymidone were added to tomato pulp in order to produce reference materials. The two most important properties of such materials are known to be homogeneity and stability. Before being shipped to other laboratories, reference materials must have their homogeneity certified. As part of a preliminary study, hundreds of samples were investigated in order to provide data on the most suitable treatments to minimize analytical variability and

  2. Effect of long-time X-ray irradiation on Cr and Hg in a polypropylene disk certified reference material observed during measurements by X-ray fluorescence spectrometry

    International Nuclear Information System (INIS)

    The effect of long-time X-ray irradiation on Cr and Hg in a polypropylene disk certified reference material (PP disk CRM, NMIJ CRM 8136-a) during measurements by X-ray fluorescence (XRF) spectrometry was examined in the present study. The XRF intensities of Cr (Kα), Hg (Lα) and Pb (Lα), obtained by an energy-dispersive (ED)-XRF spectrometer, showed the different intensity trends and the obtained XRF intensity ratios of Cr/Pb and Hg/Pb revealed decreasing and constant ratios, respectively, for long-time X-ray irradiation of up to 430 h. A similar decreasing trend of the Cr/Pb intensity ratio was also observed by wavelength-dispersive (WD)-XRF measurements for 120 h. Moreover, Cr, Hg and Pb in the PP disks obtained after long-time measurements by the WD-XRF spectrometer were measured by an ED-XRF spectrometer, and the loss of Cr was confirmed. From these results, Cr in the PP disk CRM, whose chemical form was an organometallic compound, was considered to be possibly lost during the XRF analysis for long-time or frequent measurements. (author)

  3. Stability evaluation and chemical characterization of different vegetable oils viewing the search for candidates for certified reference materials for bio diesel; Avaliacao da estabilidade e caracterizacao quimica de diferentes oleos vegetais visando a busca de candidatos a materiais de referencia certificado (MRC) para biodiesel

    Energy Technology Data Exchange (ETDEWEB)

    Cruz, Georgiana F. da; Fonseca, Mauricio G.; Goncalves, Lenise V.F.; Silva, Regina Celia F. da; Silva, Fernanda M.R. da; Rodrigues, Janaina M. [Instituto Nacional de Metrologia, Normalizacao e Qualidade Industrial (LABOR/INMETRO), Duque de Caxias, RJ (Brazil). Lab. de Analises Organicas; Leal, Rodrigo V.P. [Instituto Nacional de Metrologia, Normalizacao e Qualidade Industrial (LAMBOC/INMETRO), Duque de Caxias, RJ (Brazil). Lab. de Motores, Combustiveis e Lubrificantes], Email: rvleal@inmetro.gov.br; Cunha, Valnei S. [Instituto Nacional de Metrologia, Normalizacao e Qualidade Industrial (DIMCI/INMETRO), Duque de Caxias, RJ (Brazil). Diretoria de Metrologia Cientifica e Industrial

    2009-07-01

    Viewing the characterization of the various vegetable oils aiming to obtain a data bank that allows the production of certified reference materials for bio diesel of different blends, a study of chemical-physical characterization of different oils and derivative of bio diesel.

  4. The Certification of Methamphetamine Certified Reference Material and its Uncertainty Evaluation%甲基苯丙胺标准物质的定值与不确定度分析

    Institute of Scientific and Technical Information of China (English)

    张盼; 苏福海; 王海峰; 李红梅; 杨晶

    2012-01-01

    为了建立法庭科学毒品检测量值溯源体系,研制了甲基苯丙胺纯度标准物质。通过红外光谱、质谱法对甲基苯丙胺样品进行定性分析,优化并建立了高效液相色谱(HPLC)、差示扫描量热法(DSC)两种定值分析方法。采用热重分析法和电感耦合等离子体质谱法测定水分和无机离子的含量。通过均匀性与稳定性检验结果表明,甲基苯丙胺标准物质的均匀性良好,稳定性至少1年,同时对其进行了不确定度评定。研制的甲基苯丙胺标准物质的纯度为99.8%,扩展不确定度为0.2%(k=2)。%In order to establish the traceability system of detection value of drugs in forensic science,methamphetamine was prepared and certified as pure certified reference material(CRM).The structure of the material was qualitatively identified by IR and MS techniques.Then the principal component value was obtained through establishing the methods of HPLC and DSC.The contents of water and inorganic ion were determined by TGA and ICP-MS.Meanwhile,the uncertainty was evaluated.The test results of the homogeneity and stability showed that prepared methamphetamine had good uniformity and was stable at least 1 year,its purity was 99.8% and the expanded uncertainty was 0.2%(k=2).

  5. Certification of an iron metal reference material for neutron dosimetry (EC nuclear reference material 524)

    International Nuclear Information System (INIS)

    Iron metal, of > 99.996% nominal purity, in the form of 0.1 mm thick foil and of 0.5 mm diameter wire has been certified for its manganese and cobalt mass fractions. The certified value of the cobalt mass fraction (-1) is based on 39 accepted results from five laboratories using two different methods. The certified value of the manganese mass fraction (-1) is based on 41 accepted results from five laboratories using three different methods. The overall purity was also verified. The material is intended to be used as a reference material in neutron dosimetry. (authors). 8 refs., 9 tabs., 2 figs

  6. Reference materials and representative test materials: the nanotechnology case

    Energy Technology Data Exchange (ETDEWEB)

    Roebben, G., E-mail: gert.roebben@ec.europa.eu [Joint Research Centre of the European Commission, Institute for Reference Materials and Measurements (Belgium); Rasmussen, K. [Joint Research Centre of the European Commission, Institute for Health and Consumer Protection (Italy); Kestens, V.; Linsinger, T. P. J. [Joint Research Centre of the European Commission, Institute for Reference Materials and Measurements (Belgium); Rauscher, H. [Joint Research Centre of the European Commission, Institute for Health and Consumer Protection (Italy); Emons, H. [Joint Research Centre of the European Commission, Institute for Reference Materials and Measurements (Belgium); Stamm, H. [Joint Research Centre of the European Commission, Institute for Health and Consumer Protection (Italy)

    2013-03-15

    An increasing number of chemical, physical and biological tests are performed on manufactured nanomaterials for scientific and regulatory purposes. Existing test guidelines and measurement methods are not always directly applicable to or relevant for nanomaterials. Therefore, it is necessary to verify the use of the existing methods with nanomaterials, thereby identifying where modifications are needed, and where new methods need to be developed and validated. Efforts for verification, development and validation of methods as well as quality assurance of (routine) test results significantly benefit from the availability of suitable test and reference materials. This paper provides an overview of the existing types of reference materials and introduces a new class of test materials for which the term 'representative test material' is proposed. The three generic concepts of certified reference material, reference material(non-certified) and representative test material constitute a comprehensive system of benchmarks that can be used by all measurement and testing communities, regardless of their specific discipline. This paper illustrates this system with examples from the field of nanomaterials, including reference materials and representative test materials developed at the European Commission's Joint Research Centre, in particular at the Institute for Reference Materials and Measurements (IRMM), and at the Institute for Health and Consumer Protection (IHCP).

  7. New reference materials improvement of methods of measurements

    International Nuclear Information System (INIS)

    The report summarizes the development of about 120 reference materials in a variety of fields (non ferrous metals, trace element analysis, food products, biomedical analysis, physical and technical properties of solid materials). The document also provides practical advice for trace element analyses, describes the principles followed for certifying reference materials and provides recommendations for their use

  8. Certification of a nickel metal reference material for neutron dosimetry (EC Nuclear Reference Material 521)

    International Nuclear Information System (INIS)

    Nickel metal, of 99.99 % nominal purity and natural isotopic composition, in the form of 0.1 mm thick foil and 0.5 mm diameter wire has been certified for its cobalt mass fraction. The certified value of cobalt (<0.1μg.g-1) is based on 38 results obtained by neutron activation analysis, emission spectrometry with inductively coupled plasma excitation and atomic absorption spectrometry, whereas the isotopic composition of the nickel was verified by thermal ionization mass spectrometry. The material is intended to be used as a reference material in neutron metrology

  9. Reference materials and representative test materials: the nanotechnology case

    International Nuclear Information System (INIS)

    An increasing number of chemical, physical and biological tests are performed on manufactured nanomaterials for scientific and regulatory purposes. Existing test guidelines and measurement methods are not always directly applicable to or relevant for nanomaterials. Therefore, it is necessary to verify the use of the existing methods with nanomaterials, thereby identifying where modifications are needed, and where new methods need to be developed and validated. Efforts for verification, development and validation of methods as well as quality assurance of (routine) test results significantly benefit from the availability of suitable test and reference materials. This paper provides an overview of the existing types of reference materials and introduces a new class of test materials for which the term ‘representative test material’ is proposed. The three generic concepts of certified reference material, reference material(non-certified) and representative test material constitute a comprehensive system of benchmarks that can be used by all measurement and testing communities, regardless of their specific discipline. This paper illustrates this system with examples from the field of nanomaterials, including reference materials and representative test materials developed at the European Commission’s Joint Research Centre, in particular at the Institute for Reference Materials and Measurements (IRMM), and at the Institute for Health and Consumer Protection (IHCP).

  10. Preparation and certification of the human hair reference material

    International Nuclear Information System (INIS)

    The preparation of the human hair reference material and the steps taken to confirm its homogeneity and stability as well as its certification are described. Certified values for 17 elements, which are of importance for human health, and reference values for the other 13 elements are provided for this material. (author)

  11. A DANREF certified reference plastic for measurement of overall migration into the food simulant olive oil by single sided testing

    DEFF Research Database (Denmark)

    Lund, K. H.; Lillemark, L.; Petersen, Jens Højslev

    2000-01-01

    A reference material for the determination of overall migration from a plastic coextrudate into the fatty food simulant olive oil was produced and certified in an interlaboratory study. The analyses were carried out according to the ENV 1186 standard from the European Committee for Standardization...... (CEN) [1, 2, 3] with exposure of the coextrudate to olive oil for 10 days at 40 degrees C. After an initial preliminary interlaboratory study eight laboratories participated in the certification round, and two different methods were used to obtain single sided exposure of the plastic to the oil...

  12. Homogeneity studies in reference materials with Zeeman solid sampling GFAAS

    Energy Technology Data Exchange (ETDEWEB)

    Mohl, C.; Stoeppler, M.; Grobecker, K.H.

    1987-09-01

    The homogeneity of lead and cadmium in reference materials was investigated by solid sampling GFAAS. The following materials were comparatively analyzed: Standard reference materials from NBS, Washington 1567 wheat flour, 1568 rice flour and 1577a bovine liver, certified reference materials from BCR, Brussels, No 63 milk powder, No 184 bovine muscle, No 185 bovine liver, No 186 pig kidney, No 189 wholemeal flour, No 191 brown bread and a whole fish (dab) homogenate from the environmental specimen bank in the FRG. The results are remarkably different for the investigated materials.

  13. Development and use of reference materials and quality control materials

    International Nuclear Information System (INIS)

    Current knowledge is summarized on correct use of commercially available certified reference materials (CRMs) and reference materials (RMs). Acknowledged are also the limitations and restrictions analysts have to face if they want to apply quality control. The concept of in-house RMs or quality control materials (QCMs) is advocated to supplement the use of CRMs for quality control purposes. On hand advice on how to select, prepare, characterize and use these QCMs is given from the experts' perspective. Several scenarios are described to make this concept widely applicable to: advanced laboratories with CRMs with validated analytical techniques available, laboratories with less experience and facilities, as well as cases were labile compounds and unstable matrices are involved. Each scenario considers different approaches to overcome the lack of appropriate CRMs and advise on the preparation of QCMs, which might fit the particular purpose

  14. Preparation and characterization of the fish reference material

    International Nuclear Information System (INIS)

    The certified reference materials (CRMs) play an important role in obtaining measurement results traceable to the International System of Units, through an unbroken chain of comparisons. Thus, the demand for new certified reference materials (CRMs) increases every day in all areas of knowledge. The availability of reference materials, mainly in Brazil is still incipient, given that the demand far exceeds the available variety of these materials. The amount of certified reference materials available in the country is insufficient to meet the need of the scientific community and demands for development of new methodologies. Among the many areas in need of reference materials, we highlight the importance for the food trade balance for these products within the country. The certification of food products, intended both for export and for domestic consumption, requires analysis methods that provide precise and accurate results to ensure product quality. This paper describes the preparation and certification of a reference material in the fish matrix in mercury and methylmercury. The study brings together since the stage of material selection, preparation, development of homogeneity and stability studies and characterization. The certification was performed by means of measurements using two analytical techniques, flow injection analysis - cold vapor atomic absorption spectrometry (FIA-CV-AAS) and isotope dilution applied to mass spectrometry (IDMS), which is a primary method. In this work the standards of the ISO 30 (ABNT 30-34) and ISO Guide 35 was used as the basis for the preparation and characterization of the material. For the calculation of uncertainties was used the GUM and Eurachem guide. As a result, was produced and certified a lot of material in relation to the concentration of mercury (Hg = 0.271 ± 0.057 mg g-1) and methylmercury (MeHg = 0.245 ± 0.038 mg g-1), and informational values of lead and arsenic. (author)

  15. Nuclear measurements and reference materials

    International Nuclear Information System (INIS)

    This report summarizes the progress of the JRC programs on nuclear data, nuclear metrology, nuclear reference materials and non-nuclear reference materials. Budget restrictions and personnel difficulties were encountered during 1987. Fission properties of 235U as a function of neutron energy and of the resonances can be successfully described on the basis of a three exit channel fission model. Double differential neutron emission cross-sections were accomplished on 7Li and were started for the tritium production cross-section of 9Be. Reference materials of uranium minerals and ores were prepared. Special nuclear targets were prepared. A batch of 250 g of Pu02 was characterized in view of certification as reference material for the elemental assay of plutonium

  16. Determination of carbon-14 in environmental level, solid reference materials

    Energy Technology Data Exchange (ETDEWEB)

    Blowers, Paul, E-mail: paul.blowers@cefas.co.uk [Cefas Lowestoft Laboratory, Pakefield Road, Lowestoft, Suffolk, NR33 0HT (United Kingdom); Caborn, Jane, E-mail: jane.a.caborn@nnl.co.uk [NNL, Springfields, Salwick, Preston, Lancashire, PR4 0XJ (United Kingdom); Dell, Tony [Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, KT15 3NB (United Kingdom); Gingell, Terry [DSTL, Radiation Protection Services, Crescent Road, Alverstoke, Gosport, Hants, PO12 2DL (United Kingdom); Harms, Arvic [National Physical Laboratory, Hampton Road, Teddington, Middlesex, TW11 0LW (United Kingdom); Long, Stephanie [Radiological Protection Institute of Ireland, 3 Clonskeagh Square, Clonskeagh Road, Dublin 14, Ireland (United Kingdom); Sleep, Darren [Centre for Ecology and Hydrology, Lancaster Environment Centre, Library Avenue, Bailrigg, Lancaster, LA1 4AP (United Kingdom); Stewart, Charlie [UKAEA (Waste Management Group), Chemical Support Services, D1310/14, Dounreay, Thurso, Caithness, KW14 7TZ (United Kingdom); Walker, Jill [Radiocarbon Dating, The Old Stables, East Lockinge, Wantage, Oxon OX12 8QY (United Kingdom); Warwick, Phil E. [GAU-Radioanalytical, National Oceanography Centre Southampton, European Way, Southampton, SO14 3ZH (United Kingdom)

    2011-10-15

    An intercomparison exercise to determine the {sup 14}C activity concentrations in a range of solid, environmental level materials was conducted between laboratories in the UK. IAEA reference materials, C2, C6 and C7, and an in-house laboratory QA material were dispatched in 2006 to ten laboratories comprising of members of the Analyst Informal Working Group (AIWG) and one other invited party. The laboratories performed the determinations using a number of techniques, and using the results each one was evaluated in terms of levels of precision, sensitivity and limits of detection. The results of the study show that all techniques are capable of successfully analysing {sup 14}C in environmental level materials, however, a shortage of certified environmental reference materials exists. The suitability of the IAEA reference materials and other material for use as reference materials was also assessed.

  17. Determination of carbon-14 in environmental level, solid reference materials

    International Nuclear Information System (INIS)

    An intercomparison exercise to determine the 14C activity concentrations in a range of solid, environmental level materials was conducted between laboratories in the UK. IAEA reference materials, C2, C6 and C7, and an in-house laboratory QA material were dispatched in 2006 to ten laboratories comprising of members of the Analyst Informal Working Group (AIWG) and one other invited party. The laboratories performed the determinations using a number of techniques, and using the results each one was evaluated in terms of levels of precision, sensitivity and limits of detection. The results of the study show that all techniques are capable of successfully analysing 14C in environmental level materials, however, a shortage of certified environmental reference materials exists. The suitability of the IAEA reference materials and other material for use as reference materials was also assessed.

  18. A certified reference material for the scratch test

    OpenAIRE

    Jacobs, R.; Meneve, J.; Dyson, G.; Teer, D. G.; Jennett, N.M.; P Harris; Stebut, J. von; Comte, C.; Feuchter, P.; Cavaleiro, A; Ronkainen, H.; Holmberg, K; Beck, U.; Reiners, G.; Ingelbrecht, C. D.

    2003-01-01

    Adhesion and other mechanical behaviour of coatings is at present routinely tested in industry and research organisations using the scratch test. The test has been the subject of a European Standard prEN 1071-3:2000 established by the European Standards Committee CEN TC184 WG5. A previous European project on the development and validation of test methods for thin hard coatings--FASTE--revealed that uncertainties in the Rockwell C stylus tip shape represent a major source of error for the scra...

  19. Development of thoria certified reference materials-role of NFC

    International Nuclear Information System (INIS)

    The present paper discusses the different phases of Inter Laboratory Comparison Experiments (ILCE) program for development of thoria CRMs with a special emphasis on the role played by Control Laboratory, NFC. The preparation of ThO2 CRMs along with their importance in analysis is also explained in the paper. (author)

  20. Transuranium reference measurements and reference materials

    International Nuclear Information System (INIS)

    During the 30 years of its existence, the Central Bureau for Nuclear Measurements has been involved in numerous high-accuracy investigations of mainly nuclear properties of elements important for the nuclear fuel cycle and for application of relevant radionuclides. This paper reports that these studies were made possible by the availability of particle accelerators (150-MeV electron linear accelerator; 3.7- and 7-MV Van de Graaff accelerators) as neutron sources and the use of specialized laboratories for the preparation, characterization, and manipulation of radioactive samples. Examples of investigations with plutonium and neptunium are capture and fission cross sections of 239Pu at very low energies, spontaneous fission fragment mass and energy distributions of 242Pu at very low energies, spontaneous fission fragment mass and energy distributions of 242Pu, alpha-particle and gamma-ray spectra of 237Np, half-life of 241Pu, use of 237Np in reactor neutron dosimetry, preparation and characterization of plutonium oxide reference materials for nondestructive analysis, and demonstration of the potential of synthetic isotope mixtures for analytical control of the nuclear fuel cycle

  1. Reference Materials for Reactor Neutron Fluence Rate and Temperature Measurements

    Science.gov (United States)

    Ingelbrecht, C.

    2003-06-01

    Certified reference materials are distributed by the European Commission through the BCR® programme (over 500 CRMs) including a series of activation and fission monitor materials originally proposed by the Euratom Working Group on Reactor Dosimetry. The current range (18 CRMs) includes materials to cover the complete energy spectrum, and suitable for different irradiation times. Fission monitors are 238UO2 or 237NpO2 in the form of microspheres. Activation monitors are high purity metals (Ni, Cu, Al, Fe, Nb, Rh, or Ti), certified for interfering trace impurities, or dilute aluminium-based alloys. Reference materials newly certified are IRMM-530R A1-0.1%Au, replacing the exhausted IRMM-530 material, used as comparator for k0- standardisation, and three new Al-Co alloys (0.01, 0.1 and 1.0%Co). Others in the process of certification are A1-0.1%Ag and A1-2%Sc for thermal and epithermal fluence rate measurements and two uranium-doped glass materials intended for dosimetry by the fission-track technique. Various alloy compositions have been prepared for use as melt-wire temperature monitors with melting points ranging from 198 to 327ºC.

  2. Certification of a uranium-238 dioxide reference material for neutron dosimetry (EC nuclear reference material 501)

    International Nuclear Information System (INIS)

    Uranium-238 oxide of 99.999% isotopic and 99.98% chemical purity was transformed into dioxide spheres of nominal 0.5 and 1.0 mm diameter by gel precipitation and subsequent calcination under carbon dioxide and under argon containing 5% hydrogen at 1 125 K. The spheres were analysed by thermal ionization mass spectrometry, including isotope dilution, by gravimetry and by potentiometric titration. On the basis of these analyses, the uranium mass fraction was certified at 879.4 ± 2.8 g.kg-1, and the 235U/U - and 238U/U abundances at 10.4 ± 0.5 mg.kg-1 and 999.9896 ± 0.0005 g.kg-1, respectively. The material is intended to be used as a reference material in neutron metrology

  3. The new IAEA reference material: IAEA-434 technologically enhanced naturally occurring radioactive materials (TENORM) in phosphogypsum.

    Science.gov (United States)

    Shakhashiro, A; Sansone, U; Wershofen, H; Bollhöfer, A; Kim, C K; Kim, C S; Kis-Benedek, G; Korun, M; Moune, M; Lee, S H; Tarjan, S; Al-Masri, M S

    2011-01-01

    A reliable determination of Technologically Enhanced Naturally Occurring Radioactive Materials in phosphogypsum is necessary to comply with radiation protection and environmental regulations. In this respect, a new phosphogypsum reference material was produced and certified to assist in the validation of analytical methods and the quality assurance of produced analytical results. This paper presents the sample preparation methodology, material homogeneity assessment, characterization campaign results and assignment of property values, and associated uncertainties. The reference values and associated uncertainties for Pb-210, Ra-226, Th-230, U-234 and U-238 were established based on consensus values calculated from analytical results reported by three National Metrology Institutes and five expert laboratories.

  4. The new IAEA reference material: IAEA-434 technologically enhanced naturally occurring radioactive materials (TENORM) in phosphogypsum

    Energy Technology Data Exchange (ETDEWEB)

    Shakhashiro, A., E-mail: A.Shakhashiro@iaea.or [International Atomic Energy Agency, Agency' s Laboratories, Vienna International Center, PO Box 100, A-1400 Vienna (Austria); Sansone, U. [International Atomic Energy Agency, Agency' s Laboratories, Vienna International Center, PO Box 100, A-1400 Vienna (Austria); Wershofen, H. [Environmental Radioactivity, PTP, Braunschweig (Germany); Bollhoefer, A. [Environmental Radioactivity, Department of the Environment and Heritage, Darwin (Australia); Kim, C.K. [International Atomic Energy Agency, Agency' s Laboratories, Vienna International Center, PO Box 100, A-1400 Vienna (Austria); Kim, C.S. [Department of Environmental Radioactivity Assessment, Korea Institute of Nuclear Safety, Daejeon, Republic of Korea (Former collaborator) (Korea, Republic of); Kis-Benedek, G. [International Atomic Energy Agency, Agency' s Laboratories, Vienna International Center, PO Box 100, A-1400 Vienna (Austria); Korun, M. [Jozef Stefan Institute, Ljubljana (Slovenia); Moune, M. [LNE-LNHB, Laboratoire National Henri Becquerel, Gif-sur-Yvette Cedex (France); Lee, S.H. [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of); Tarjan, S. [Central Radiological Laboratory, Hungarian Agricultural Authority, Budapest (Hungary); Al-Masri, M.S. [Atomic Energy Commission of Syria, Damascus (Syrian Arab Republic)

    2011-01-15

    A reliable determination of Technologically Enhanced Naturally Occurring Radioactive Materials in phosphogypsum is necessary to comply with radiation protection and environmental regulations. In this respect, a new phosphogypsum reference material was produced and certified to assist in the validation of analytical methods and the quality assurance of produced analytical results. This paper presents the sample preparation methodology, material homogeneity assessment, characterization campaign results and assignment of property values, and associated uncertainties. The reference values and associated uncertainties for Pb-210, Ra-226, Th-230, U-234 and U-238 were established based on consensus values calculated from analytical results reported by three National Metrology Institutes and five expert laboratories.

  5. Certification for copper concentration in reference material for fuel anhydro ethylic alcohol; Certificacao da concentracao de cobre em material de referencia para alcool etilico anidro combustivel (AEC)

    Energy Technology Data Exchange (ETDEWEB)

    Reis, Lindomar Augusto dos; Rocha, Marcia Silva da; Mesko, Marcia Foster; Silva, Fagner Francisco da; Quaresma, Maria Cristina Baptista; Araujo, Thiago Oliveira [Instituto Nacional de Metrologia, Normalizacao e Qualidade Industrial (DIMCI/INMETRO), Duque de Caxias, RJ (Brazil). Diretoria de Metrologia Cientifica e Industrial], E-mail: lareis@inmetro.gov.br

    2009-07-01

    This work aiming to obtain the first certified reference material for fuel anhydro ethylic alcohol relative to the copper concentration, which has his maximum limit determined by the in force legislation providing traceability and reliability for the measurement results.

  6. 40 CFR 1042.910 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... reference as prescribed in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Reference materials. 1042.910 Section... Other Reference Information § 1042.910 Reference materials. Documents listed in this section have...

  7. Reference material for radionuclides in sediment IAEA-384 (Fangataufa Lagoon sediment)

    DEFF Research Database (Denmark)

    Povinec, P.P.; Pham, M.K.; Sanchez-Cabeza, J.A.;

    2007-01-01

    A reference material designed for the determination of anthropogenic and natural radionuclides in sediment, IAEA-384 (Fangataufa Lagoon sediment), is described and the results of certification are presented. The material has been certified for 8 radionuclides (K-40, Co-60, Eu-155, Th-230, U-238, ...

  8. Bisphenol A polycarbonate as a reference material

    Science.gov (United States)

    Hilado, C. J.; Cumming, H. J.; Williams, J. B.

    1977-01-01

    Test methods require reference materials to standardize and maintain quality control. Various materials have been evaluated as possible reference materials, including a sample of bisphenol A polycarbonate without additives. Screening tests for relative toxicity under various experimental conditions were performed using male mice exposed to pyrolysis effluents over a 200-800 C temperature range. It was found that the bisphenol A polycarbonate served as a suitable reference material as it is available in large quantities, and does not significantly change with time.

  9. Primary certification of reference material for electrolytic conductivity of bioethanol

    Science.gov (United States)

    da Silva, L. F.; Gomes, M. R. F.; Cassini, G. C.; Faria, A. C. V.; Fraga, I. C. S.

    2016-07-01

    Nowadays the preservation of the planet is spreading into the international scene with the use of renewable energy sources such as bioethanol. The challenge is to guarantee the quality of produced bioethanol, and the electrolytic conductivity (EC) is one of the specified parameters for this purpose. However, is necessary to demonstrate the metrological traceability of the measurement results for EC in this matrix. This study presents the certification of a reference material for EC in bioethanol by using only primary measurements. The value of primary certified reference material (CRM) is (0.77 ± 0.06) µS.cm-1, and its use will provide the metrological traceability needed for measurement results in laboratories.

  10. 40 CFR 1043.100 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air and Radiation... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Reference materials. 1043.100 Section... § 1043.100 Reference materials. Documents listed in this section have been incorporated by reference...

  11. Reference to the Safety Engineering Undergraduate Courses to Improve the Subjects and Contents of the Certified Safety Engineer Qualification and Examination System of China

    OpenAIRE

    Haibin Qiu; Shanghong Shi; Tingdi Zhao; Yiwei Qiao; Jiangshi Zhang

    2013-01-01

    The aim of this paper is to recommend that the subjects and contents of certified safety engineers use safety engineering undergraduate curriculum system for reference. Human resources play an important role in accident prevention and loss control. Education on safety engineering develops quickly in China. Moreover, the State Administration of Work Safety and the National Human Resources and Social Security Ministry have implemented a certified safety engineer qualification and examination sy...

  12. Preparation, characterization and certification of uranium isotope reference materials

    International Nuclear Information System (INIS)

    This work describes the preparation, characterization and certification of a set of uranium isotope reference materials ranging from 0.5 to 20.0 % of 235U in mass. The most important concepts of metrology in chemical measurements were applied so that the certified quantities in these materials could be directly traceable to the International System of Units (SI). As a consequence of this approach, these materials can be used in the instruments calibration, estimation of measurement uncertainty, method validation, assessment of performance of analysts, quality control routines and interlaboratory comparison programmes. The most advanced methods and techniques in mass spectrometry, that is, gas source mass spectrometry (GSMS), thermal ionisation mass spectrometry (TIMS) and inductively coupled plasma mass spectrometry (ICPMS) were investigated to identify which are the dominant components in the uncertainty and to quantify its contribution to the final value of the measurement uncertainty of the isotopic ratio. The results obtained were then compared to verify which are the methods and techniques associated to the lowest measurement uncertainty values. The isotope amount ratio n(235U)/n(238U) was certified in the materials produced to expanded uncertainties ranging from 0.02 to 0.10 % and the ratios n(234U)/n(238U) and n(236U)/n(238U), to uncertainties ranging from 0.03 to 2.20 %. These values fully comply to the requirements of the isotopic characterization of nuclear fuel as well as the analysis of environmental samples for nuclear safeguards. (author)

  13. Preparation and characterization of the fish reference material; Preparacao e caracterizacao de um material de referencia de peixe

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Joao Cristiano

    2011-07-01

    The certified reference materials (CRMs) play an important role in obtaining measurement results traceable to the International System of Units, through an unbroken chain of comparisons. Thus, the demand for new certified reference materials (CRMs) increases every day in all areas of knowledge. The availability of reference materials, mainly in Brazil is still incipient, given that the demand far exceeds the available variety of these materials. The amount of certified reference materials available in the country is insufficient to meet the need of the scientific community and demands for development of new methodologies. Among the many areas in need of reference materials, we highlight the importance for the food trade balance for these products within the country. The certification of food products, intended both for export and for domestic consumption, requires analysis methods that provide precise and accurate results to ensure product quality. This paper describes the preparation and certification of a reference material in the fish matrix in mercury and methylmercury. The study brings together since the stage of material selection, preparation, development of homogeneity and stability studies and characterization. The certification was performed by means of measurements using two analytical techniques, flow injection analysis - cold vapor atomic absorption spectrometry (FIA-CV-AAS) and isotope dilution applied to mass spectrometry (IDMS), which is a primary method. In this work the standards of the ISO 30 (ABNT 30-34) and ISO Guide 35 was used as the basis for the preparation and characterization of the material. For the calculation of uncertainties was used the GUM and Eurachem guide. As a result, was produced and certified a lot of material in relation to the concentration of mercury (Hg = 0.271 {+-} 0.057 mg g{sup -1}) and methylmercury (MeHg = 0.245 {+-} 0.038 mg g{sup -1}), and informational values of lead and arsenic. (author)

  14. Survey of reference materials. V. 2: Environmentally related reference materials for trace elements, nuclides and microcontaminants

    International Nuclear Information System (INIS)

    The present report presently contains over 250 reference materials with trace element and organic contaminant information on fuel, geological and mineral, anthropogenic disposal, soil reference and miscellaneous reference materials. Not included in the current report is information on most biological and environmental reference materials with trace element, stable isotope, radioisotope and organic contaminant information. 8 refs, tabs

  15. Speciation of dimethylarsinyl-riboside derivatives (arsenosugars) in marine reference materials by HPLC-ICP-MS

    DEFF Research Database (Denmark)

    Larsen, Erik Huusfeldt

    1995-01-01

    (cf. Table 2) were present in shellfish certified reference materials (CRMs) and in a lobster hepatopancreas CRM. The concentration of the two arsenosugars in the shellfish samples amounts to 18% of the total arsenic as compared to arsenobetaine at 9–13% and dimethylarsinate at 4–9% of the total...

  16. Elemental determinations in NBS 1633A Fly Ash Standard Reference material using INAA PGNAA

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, J.R.; Schlegel, S.C. (Missouri Univ., Columbia (USA). Research Reactor Facility)

    1985-02-01

    INAA was used for the determination of 23 elements, and prompt gamma neutron activation analysis (PGNAA) for the determination of 10 elements in U.S. National Bureau of Standards (NBS) 1633A Fly Ash Standard Reference Material. The results are in excellent agreement with the limited number of NBS certified values available.

  17. Lawrence Livermore National Laboratory Working Reference Material Production Pla

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Amy; Thronas, Denise; Marshall, Robert

    1998-11-04

    This Lawrence Livermore National Laboratory (LLNL) Working Reference Material Production Plan was written for LLNL by the Los Alamos National Laboratory to address key elements of producing seven Pu-diatomaceous earth NDA Working Reference Materials (WRMS). These WRMS contain low burnup Pu ranging in mass from 0.1 grams to 68 grams. The composite Pu mass of the seven WRMS was designed to approximate the maximum TRU allowable loading of 200 grams Pu. This document serves two purposes: first, it defines all the operations required to meet the LLNL Statement of Work quality objectives, and second, it provides a record of the production and certification of the WRMS. Guidance provided in ASTM Standard Guide C1128-89 was used to ensure that this Plan addressed all the required elements for producing and certifying Working Reference Materials. The Production Plan was written to provide a general description of the processes, steps, files, quality control, and certification measures that were taken to produce the WRMS. The Plan identifies the files where detailed procedures, data, quality control, and certification documentation and forms are retained. The Production Plan is organized into three parts: a) an initial section describing the preparation and characterization of the Pu02 and diatomaceous earth materials, b) middle sections describing the loading, encapsulation, and measurement on the encapsulated WRMS, and c) final sections describing the calculations of the Pu, Am, and alpha activity for the WRMS and the uncertainties associated with these quantities.

  18. Developing a matrix reference material for screening of transgenic rice.

    Science.gov (United States)

    Li, Jun; Wu, Yuhua; Li, Xiaofei; Wang, Yulei; Zhang, Li; Li, Yunjing; Wu, Gang

    2015-12-01

    Certified reference materials (CRMs) that are compatible with detection methods are needed to detect genetically modified organisms (GMOs). Screening is the first detection step in determining the possible presence of GMO ingredients in food or feed; however, screening has been hindered by the lack of GMO CRMs. In this study, transgenic rice materials were developed via the transformation of a construct harboring 11 commonly used screening elements. Digital PCR was utilized to identify a homozygous single-copy line termed SDrice. The qualitative detections of 11 elements in 21 transgenic materials demonstrated that the genomic DNA of the SDrice was suitable for use as a positive control in the screening of GMO ingredients. The suitability of SDrice as reference material was further checked by testing the sensitivity of 11 known conventional PCR assays, ranging from 10 to 50 copies of the SDrice genome. The standard curves that were created using SDrice DNA series as calibrators all exhibited good linearities in the relationships of the Ct values with the template copy numbers in these 11 real-time PCR assays. The LODs of the real-time PCR assays were estimated to be two to five copies of the SDrice genome. Comparisons of the SDrice with other GM rice revealed that significant differences existed in both the intercepts of the standard curves and the ΔCt values of the exogenous and reference genes for the P-35S, T-nos, HPT, T-35S, and Bar assays; the SDrice was not fit for quantification of other GM rice events. This study provided a matrix reference material (RM) that was suitable for screening GM rice, determination of sensitivity and a LOD of PCR assays, and overcame some of the drawbacks of plasmid DNA as reference material.

  19. Developing a matrix reference material for screening of transgenic rice.

    Science.gov (United States)

    Li, Jun; Wu, Yuhua; Li, Xiaofei; Wang, Yulei; Zhang, Li; Li, Yunjing; Wu, Gang

    2015-12-01

    Certified reference materials (CRMs) that are compatible with detection methods are needed to detect genetically modified organisms (GMOs). Screening is the first detection step in determining the possible presence of GMO ingredients in food or feed; however, screening has been hindered by the lack of GMO CRMs. In this study, transgenic rice materials were developed via the transformation of a construct harboring 11 commonly used screening elements. Digital PCR was utilized to identify a homozygous single-copy line termed SDrice. The qualitative detections of 11 elements in 21 transgenic materials demonstrated that the genomic DNA of the SDrice was suitable for use as a positive control in the screening of GMO ingredients. The suitability of SDrice as reference material was further checked by testing the sensitivity of 11 known conventional PCR assays, ranging from 10 to 50 copies of the SDrice genome. The standard curves that were created using SDrice DNA series as calibrators all exhibited good linearities in the relationships of the Ct values with the template copy numbers in these 11 real-time PCR assays. The LODs of the real-time PCR assays were estimated to be two to five copies of the SDrice genome. Comparisons of the SDrice with other GM rice revealed that significant differences existed in both the intercepts of the standard curves and the ΔCt values of the exogenous and reference genes for the P-35S, T-nos, HPT, T-35S, and Bar assays; the SDrice was not fit for quantification of other GM rice events. This study provided a matrix reference material (RM) that was suitable for screening GM rice, determination of sensitivity and a LOD of PCR assays, and overcame some of the drawbacks of plasmid DNA as reference material. PMID:26462921

  20. Biological reference materials from the National Institute for Environmental Studies (Japan)

    Energy Technology Data Exchange (ETDEWEB)

    Okamoto, Kensaku

    1988-12-01

    The National Institute for Environmental Studies has recently undertaken the development of two new biological reference materials, Sargasso and Rice Flour-Unpolished, for trace element analysis. The sargasso seaweed (Sargassum felvellum) reference material contains high levels of alkali, alkaline earth elements and As, together with low concentrations of heavy metals. The rice flour-unpolished reference material was prepared from unpolished rice collected from three different locations in Japan. This reference material consists of three samples, each containing different levels (low, medium, high) of Cd. This paper presents the preparation and elemental composition of NIES Sargasso and Rice Flour-Unpolished reference materials, following a brief description of each of the currently available NIES certified reference materials.

  1. Environmental reference materials methods and case studies

    DEFF Research Database (Denmark)

    Schramm-Nielsen, Karina Edith

    1998-01-01

    evaluation of certification data. The plots illustrate consistency between replicate measurements on samples from a batch of reference material, carried out in a number of laboratories according to a staggered nested design. The development of a reference material is illustrated by a series of experiments......This thesis introduces the reader to the concept of chemical environmental reference materials and their role in traceability and chemical analyses of the environment. A number of models and principles from the literature are described. Some suggestions are made as to how stability studies can...

  2. delta 15N and non-carbonate delta 13C values for two petroleum source rock reference materials and a marine sediment reference material

    Science.gov (United States)

    Dennen, Kristin O.; Johnson, Craig A.; Otter, Marshall L.; Silva, Steven R.; Wandless, Gregory A.

    2006-01-01

    Samples of United States Geological Survey (USGS) Certified Reference Materials USGS Devonian Ohio Shale (SDO-1), and USGS Eocene Green River Shale (SGR-1), and National Research Council Canada (NRCC) Certified Marine Sediment Reference Material (PACS-2), were sent for analysis to four separate analytical laboratories as blind controls for organic rich sedimentary rock samples being analyzed from the Red Dog mine area in Alaska. The samples were analyzed for stable isotopes of carbon (delta13Cncc) and nitrogen (delta15N), percent non-carbonate carbon (Wt % Cncc) and percent nitrogen (Wt % N). SDO-1, collected from the Huron Member of the Ohio Shale, near Morehead, Kentucky, and SGR-1, collected from the Mahogany zone of the Green River Formation are petroleum source rocks used as reference materials for chemical analyses of sedimentary rocks. PACS-2 is modern marine sediment collected from the Esquimalt, British Columbia harbor. The results presented in this study are, with the exceptions noted below, the first published for these reference materials. There are published information values for the elemental concentrations of 'organic' carbon (Wt % Corg measured range is 8.98 - 10.4) and nitrogen (Wt % Ntot 0.347 with SD 0.043) only for SDO-1. The suggested values presented here should be considered 'information values' as defined by the NRCC Institute for National Measurement Reference Materials and should be useful for the analysis of 13C, 15N, C and N in organic material in sedimentary rocks.

  3. Standard Reference Development of nuclear material for Tensile and Hardness Test Properties

    Energy Technology Data Exchange (ETDEWEB)

    Choo, Y. S.; Kim, D. S.; Yoo, B. O.; Ahn, S. B.; Baik, S. J.; Chun, Y. B.; Kim, K. H.; Hong, K. P.; Ryu, W. S

    2007-12-15

    Standard reference is a official approved data such a coefficient of physics, approved material properties, and etc., which should be analyzed and evaluated by scientific method to acquire official approval for accuracy and credibility of measured data and information. So it could be used broadly and continuously by various fields of nation and society. It is classified to effective standard reference, verified standard reference, and certified standard reference. There are sixteen fields in designated standard references such a physical chemistry field, material field, metal field, and the others. The standard reference of neutron irradiated nuclear structural material is classified to metal field. This report summarized the whole processes about data collection, data production, data evaluation and the suggestion of details evaluation technical standard for tensile and hardness properties, which were achieved by carry out the project 'nuclear material standard reference development' as a result.

  4. Overview of Uranium Isotopic Reference Materials at IRMM

    Science.gov (United States)

    Alonso-Munoz, A.; Richter, S.; Eykens, R.; Aregbe, Y.; Kuehn, H.; Verbruggen, A.

    2007-12-01

    For many applications in the geological sciences, in particular in geochemistry research, isotope ratio measurements play a significant role. For instance, in geochronology isotope abundances of uranium and its daughter products thorium and lead have been used since more than five decades to determine the age of various samples of geological interest. However, in order to validate mass spectrometric measurement procedures and to calibrate detector systems, suitable isotope reference materials are needed. IRMM is a well recognized provider for nuclear isotope reference materials to the nuclear industry and nuclear safeguards authorities, which can also be used for geological applications. This paper gives an overview of isotope reference materials for uranium prepared and certified at IRMM. These materials are synthetic isotope reference materials prepared based on proven methods of purifying and mixing highly enriched oxides. Firstly, a set of 10 mixtures of 233U, 235U and 238U was made in which the 235U/238U ratios were kept at 1:1 and the 233U/235U ratios varied from 1.0 to 10-6 (IRMM-072). This set is ideal for checking the linearity response of detectors used in isotope mass spectrometry. Recently, after the IRMM-072 series was exhausted, it has been replaced by the IRMM-073 and IRMM-074 series. Secondly the double spike IRMM-3636 with a 233U/236U ratio of 1:1 was prepared which allows internal mass fractionation correction for high precision 235U/238U ratio measurements. The 234U abundance of this double spike material is low enough to allow an accurate and precise correction of 234U/238U ratios, even for measurements of close to equilibrium uranium samples.

  5. Certification of B-group vitamins (b1, b2, b6, and b12) in four food reference materials

    NARCIS (Netherlands)

    Ollilainen, V.; Finglas, P.M.; Berg, H. van den; Froidmont-Görtz, I. de

    2001-01-01

    In 1989, the Community Bureau of Reference started a research program to improve the quality of vitamin analysis in food. To achieve this task, vitamin methodology was evaluated and tested by interlaboratory studies and the preparation of certified reference materials, which will be used for quality

  6. Reference material for natural radionuclides in glass designed for underground experiments

    OpenAIRE

    Povinec, P.; PHAM M. K.; Busto, J.; Cerna, C.; Degering, D.; Y. Hamajima; Holy, K.; Hult, Mikael; Jeskovsky, M.; Koehler, M; Kovacik, A.; Laubenstein, Matthias; Loaiza, P.; Mamedov, F.; Marquet, C.

    2015-01-01

    A reference material designed for the determination of natural radionuclides in solid samples (glass pellets) is described and the results of certification are presented. The material has been certified for 7 natural radionuclides (40K, 226Ra, 228Ra, 228Th, 232Th, 235U and 238U). An information value is given for 210Pb. Radon (222Rn) emanation experiments showed results comparable within participating laboratories, however, the number of data and precision was too low to carry out a certifica...

  7. 49 CFR 171.7 - Reference material.

    Science.gov (United States)

    2010-10-01

    ... A and B), V, VIII (Division 1), and IX of 1998 Edition of American Society of Mechanical Engineers... sections in which the material is referenced. Source and name of material 49 CFR reference American... Infectious Agents, 1998 173.134 American Institute of Chemical Engineers (AIChE), 3 Park Avenue New York,...

  8. Instrumental neutron activation analysis of marine sediment in-house reference material

    International Nuclear Information System (INIS)

    Reference materials play an important role in demonstrating the quality and reliability of analytical data. The advantage of using in-house reference materials is that they provide a relatively cheap option as compared to using commercially available certified reference material (CRM) and can closely resemble the laboratory routine test sample. A marine sediment sample was designed as an in-house reference material, in the framework of quality assurance and control (QA/QC) program of the Neutron Activation Analysis (NAA) Laboratory at Nuclear Malaysia. The NAA technique was solely used for the homogeneity test of the marine sediment sample. The CRM of IAEA- Soil 7 and IAEA- SL1 (Lake Sediment) were applied in the analysis as compatible matrix based reference materials for QA purposes. (Author)

  9. Certification of a meat reference material based on a collaborative study

    Directory of Open Access Journals (Sweden)

    Claudia Marcela Salazar Arzate

    2013-01-01

    Full Text Available Through a collaborative project, comparison studies were carried out to improve measurement capabilities of participating laboratories, supporting them to produce, characterize and distribute reference materials in the food sector. The project was planned in four annual stages (milk, water, meat and grains. The third stage aimed specifically to quantify and certify the nutritional content of the parameters (nitrogen, fat, sodium and potassium of a batch candidate as Certified Reference Material (CRM of canned beef. This study was conducted in collaboration between several National Metrology Institutes (NMIs and/or collaborating laboratories, which, once identified the possible causes of variability or bias in the measurements, as well as the opportunities of improvement, achieved the certification of the material beef. The CRM was distributed among the participants to cover the needs of the food industry of meat products and testing laboratories in their respective countries.

  10. Agricultural biological reference materials for analytical quality control

    Energy Technology Data Exchange (ETDEWEB)

    Ihnat, M.

    1986-01-01

    Cooperative work is under way at Agriculture Canada, US Department of Agriculture, and US National Bureau of Standards in an attempt to fill some of the gaps in the world repertoire of reference materials and to provide much needed control materials for laboratories' day to day operations. This undertaking involves the preparation and characterization of a number of agricultural and food materials for data quality control for inorganic constituents. Parameters considered in the development of these materials were material selection based on importance in commerce and analysis; techniques of preparation, processing, and packaging; physical and chemical characterization; homogeneity testing and quantitation (certification). A large number of agricultural/food products have been selected to represent a wide range of not only levels of sought-for constituents (elements) but also a wide range of matrix components such as protein, carbohydrate, dietary fiber, fat, and ash. Elements whose concentrations are being certified cover some two dozen major, minor, and trace elements of nutritional, toxicological, and environmental significance.

  11. Report of the research co-ordination meeting on reference materials for microanalytical nuclear techniques

    International Nuclear Information System (INIS)

    Many microanalytical procedure require specific natural-matrix reference materials containing very low levels of trace elements and having a high degree of homogeneity. This proposed CRP will specifically address the question of quality control materials for these techniques. The participants of the meeting discussed the requirements for certified reference materials to by used in microanalysis with particular emphasis on the homogeneity issues. This publication contains summary of the discussions along with conclusions and recommendations made by the participants. The publication also contains 13 individual presentations delivered by the participants. Each of the individual papers has been provided with an abstract and indexed separately

  12. Development of solid radium-226 reference materials

    International Nuclear Information System (INIS)

    Radium-226 reference materials having a matrix similar to soil or tailings samples are not available in sufficient quantity for use by remedial-action contractors to calibrate their laboratory gamma-ray spectrometers. Such reference materials are needed to provide uniform standardization among measurements made by remedial-action contractors. A task, therefore, was undertaken to prepare about 200 pounds each of three different concentrations of radium-226 reference materials by diluting tailings with high-purity silica. Target values for radium-226 content were 50, 15, and 5 pCi/g. The radium-226 content of the reference materials was measured by C.W. Sill of EG and G Idaho, Inc., Idaho Falls, using a high- resolution alpha spectrometry technique standardized with National Bureau of Standards (NBS) standard 4961. A summary of this technique is provided in Appendix A of this report. An independent measurement of the radium-226 content was conducted by Bendix Field Engineering Corporation (Bendix), Grand Junction, Colorado, using a high-resolution Ge(Li) detector, which was calibrated using the New Brunswick Laboratory (NBL) 100-A Series standards. The Ge(Li) detector has also been used to determine the radium-226 content in the calibration models at the Grand Junction facility; these models are used by remedial-action contractors for calibration of borehole logging gamma-ray probes. 8 references, 12 tables

  13. Analysis of soil reference materials for vanadium(+5) species by electrothermal atomic absorption spectrometry

    International Nuclear Information System (INIS)

    Solid Certified Reference Materials (CRMs) with known vanadium(+5) content are currently not commercially available. Because of this, vanadium species have been determined in solid CRMs of soil, viz. CRM023-50, CRM024-50, CRM049-50, SQC001 and SQC0012. These CRMs are certified with only total vanadium content. Vanadium(+5) was extracted from soil reference materials with 0.1 M Na2CO3. The quantification of V(+5) was carried out by electrothermal atomic absorption spectrometry (ET-AAS). The concentration of V(+5) in the analyzed CRMs was found to be ranging between 3.60 and 86.0 μg g-1. It was also found that SQC001 contains approximately 88% of vanadium as V(+5) species. Statistical evaluation of the results of the two methods by paired t-test was in good agreement at 95% level of confidence.

  14. Neutron activation analysis of reference materials

    International Nuclear Information System (INIS)

    The importance is pointed out of neutron activation analysis in the preparation of reference materials, and studies are reported conducted recently by UJV. Instrumental neutron activation analysis has been used in testing homogeneity and in determining 28 elements in newly prepared reference standards of coal fly ash designated ENO, EOP and ECH. For accuracy testing, the same method was used in the analysis of NBS SRM-1633a Trace Elements in Coal Fly Ash and IAEA CRM Soil-5 and RM Soil-7. Radiochemical neutron activation analysis was used in determining Cd, Cu, Mn, Mo, and Zn in biological materials NBS SRM-1577 Bovine Liver, Bowen's Kale and in IAEA RM Milk Powder A-11 and Animal Muscle H-4. In all instances very good precision and accuracy of neutron activation analysis results were shown. (author)

  15. AQCS intercomparison runs, reference materials 1991

    International Nuclear Information System (INIS)

    The purpose of the Analytical Quality Control Services programme provided by the IAEA is to assist laboratories engaged in the analysis of nuclear, environmental, biological, and materials of marine origin for radionuclide, major, minor and trace elements, as well as stable isotopes using atomic and nuclear analytical techniques, to check the quality of their work. The determination of accuracy requires special procedures such as analysis to be carried out by as many different and independent methods, analysts and techniques as possible, control analysis with reference materials and participation in interlaboratory comparison studies. This document gives details of the specimens and samples which the IAEA intends to distribute in 1991. Tabs

  16. Certification of uranium hexafluoride reference materials for isotopic composition

    International Nuclear Information System (INIS)

    The IRMM-019 to IRMM-029 series of uranium hexafluoride materials is certified for the isotopic composition. After conversion into uranyl nitrate solution, certification and homogeneity measurements were performed by thermal ionization mass spectrometry. Analyses were performed by Modified Total Evaporation and for some materials the major isotope amount ratio n(235U)/n(238U) was measured using a n(233U)/n(236U) double spike. Measurements were confirmed by UF6 gas source mass spectrometry. Major isotope amount ratios were certified with relative expanded uncertainties (k = 2) of 0.015-0.030 % and the minor isotope amount ratios n(234U)/n(238U) and n(236U)/n(238U) were certified with relative expanded uncertainties of 0.02-3 %. (author)

  17. Preparation and characterization of a Perna perna (Linnaeus, 1758) mussel reference material

    International Nuclear Information System (INIS)

    The use of certified reference materials in chemical analysis is an important requirement in quality assurance systems, as it allows the validation of analytical methods and the realization of the metrological traceability of results. Then, it is possible to obtain valid and comparable results not only in space, but also in time. In this study, all the steps for the preparation of a national mussel reference material were attained, from the collection of the bulk material to processing steps such as freeze-drying, grinding, bottling and sterilization. Internationally accepted principles were applied for the homogeneity and stability assessment of the material, using instrumental neutron activation analysis and atomic absorption spectrometry as analytical techniques. By means of a collaborative program with participation of Brazilian and foreign laboratories, the chemical characterization of the material was performed. Element content in the mass percentage to mg kg-1 range was determined for 47 elements and some radionuclides, naturally present in the material. With the application of suitable statistical treatment to the data, it was considered that the content of 11 of those elements may be certified: As, Ca, Cl, Co, K, Mg, Mn, Na, Se, Th and Zn. This study may be considered an important step in the national metrological development, as it shows that the production and characterization of biological reference materials, mussel in particular, is feasible in Brazil, as a tool for quality assurance of environmental and nutritional studies performed in the country. (author)

  18. Reference material systems: a sourcebook for material assessment

    Energy Technology Data Exchange (ETDEWEB)

    Bhagat, N. (ed.)

    1976-12-01

    A reference set of data related to material systems and a framework for carrying out the material technologies assessment are presented. While the bulk of renewables have been considered in this report, the nonrenewable materials dealt with here include structural materials only, such as steel, aluminum, cement and concrete, and bricks. The complete data set is supposed to include material flows, energy requirements, capital and labor inputs, and environmental effects for each process that a resource must go through to become a useful material for an end use. Although effort has been made to obtain as much information as possible, considerable gaps in data, apparent throughout this report, could not be avoided. A new material technology can be evaluated by substituting that technology for appropriate elements of the reference materials system and calculating the net change in material resource, energy, capital and labor requirements, and environmental impacts. This combination of information thus serves as a means of evaluating the potential benefits to be gained by research in various material technologies.

  19. Feasibility Study for the Development of Plutonium Reference Materials for Age Dating in Nuclear Forensics

    International Nuclear Information System (INIS)

    Isotopic reference materials certified for the age of nuclear material (uranium, plutonium) are needed in the fields of nuclear forensics and environmental measurements. Therefore a feasibility study for the development of plutonium reference materials for age dating has been started recently at the Institute for Reference Materials and Measurements (EC-JRC-IRMM). The ''age'' of the material is defined as the time that has passed since the last chemical separation of the mother and daughter isotopes (e.g. 241Pu and 241Am). Assuming that the separation has been complete and all the daughter isotopes have been removed from the original material during this last separation, the age of the material can be determined by measuring the ratio of daughter and mother radio-nuclides, e.g. 241Am/241Pu. At a given time after the last separation and depending on the half lives of the radio-nuclides involved, a certain amount of the daughter radionuclide(s) will be present. For the determination of the unknown age of a material different ''clocks'' can be used; ''clocks'' are pairs of mother and daughter radio-nuclides, such as 241Am/241Pu, 238Pu/234U, 239Pu/235U, 240Pu/236U, and possibly 242Pu/238U. For the age estimation of a real sample, such as material seized in nuclear forensics investigations or dust samples in environmental measurements, it is advisable to use more than one clock in order to ensure the reliability of the results and to exclude the possibility that the sample under question is a mixture of two or more materials. Consequently, a future reference material certified for separation date should ideally be certified for more than one ''clock'' or several reference materials for different ''clocks'' should be developed. The first step of this study is to verify the known separation dates of different plutonium materials of different ages and isotopic compositions by measuring the mother (238Pu, 239Pu, 240Pu, 241Pu, 242Pu) and daughter (234U, 235U, 236U, 238U and

  20. Future needs and requirements for AMS {sup 14}C standards and reference materials

    Energy Technology Data Exchange (ETDEWEB)

    Scott, E. Marian E-mail: marian@stats.gla.ac.uk; Boaretto, Elisabetta; Bryant, Charlotte; Cook, Gordon T.; Gulliksen, Steinar; Harkness, Doug D.; Heinemeier, Jan; McGee, Edward; Naysmith, Philip; Possnert, Goran; Plicht, Hans van der; Strydonck, Mark van

    2004-08-01

    {sup 14}C measurement uses a number of standards and reference materials with different properties. Historically the absolute calibration of {sup 14}C measurement was tied to 1890 wood, through the 'primary' standard of NBS-OxI (produced by the National Bureau of Standards, now NIST - National Institute of Standards and technology) subsequently replaced by NBS-OxII. These are both internationally calibrated and certified materials, whose {sup 14}C activities are known absolutely. A second tier of materials, often called secondary standards or reference materials, and including internationally recognised materials such as ANU-sucrose (now also IAEA-C6), Chinese - sucrose and the IAEA C1-C6 series, augmented by additional oxalic acid samples are also used routinely. The activity of these materials has been estimated from large numbers of measurements made by many laboratories. Recently, further natural materials from the Third and Fourth International Radiocarbon Inter-comparisons (TIRI and FIRI) have been added to this list. The activities of these standards and reference materials span both the applied {sup 14}C age range and the chemical composition range of typical samples, but this is not achieved uniformly and there is a continuing need for reference materials for laboratory quality control and measurement-traceability purposes. In this paper, we review the development of {sup 14}C standards and reference materials and consider the future requirements for such materials within the {sup 14}C AMS community.

  1. Reference material manufacture and certification for the AVNG

    Energy Technology Data Exchange (ETDEWEB)

    Hauck, Danielle K [Los Alamos National Laboratory; Thron, Jonathan [Los Alamos National Laboratory; MacArthur, Duncan W. [Los Alamos National Laboratory; Livke, Alexander [RFNC - VNIIEF; Bulatov, M [RFNC-VNIIEF; Kondratov, Sergey [RFNC-VNIIEF; Leplyavkina, M [RFNC-VNIIEF; Razinkov, Sergey [RFNC-VNIIEF; Sivachev, D [RFNC-VNIIEF; Tsybryaev, S [RFNC-VNIIEF; V' yushin, A [RFNC-VNIIEF

    2010-07-09

    Testing and demonstration of any radiation measurement system requires the use of appropriate radioactive sources. An attribute measurement system (A VNG) was developed and fabricated at the Russian Federal Nuclear Center, VNIIEF, Russia, under contract with LANL, USA. The A VNG detects neutron and gamma radiation signatures and compares the data analysis results with the specified threshold values for three unclassified attributes; plutonium is present or absent, plutonium mass is greater than or less than the specified threshold value and plutonium isotopic ratio 240Pu to 239Pu) is greater than or less then the threshold value. A set of reference materials (RMs) was specially manufactured for the A VNG with masses and isotopic ratios above and below the selected thresholds. The set of RMs was certified in compliance with the Russian metrological requirements. The RMs were used to debug and test the A VNG and to demonstrate the A VNG operation to an American delegation in June 2009. In this presentation, we will describe the various steps in the manufacture and certification of these RM sources.

  2. Reference material manufacture and certification for the AVNG

    Energy Technology Data Exchange (ETDEWEB)

    Hauck, Danielle K [Los Alamos National Laboratory; Mac Arthur, Duncan [Los Alamos National Laboratory; Thron, Jonathan L [Los Alamos National Laboratory; Livke, Alexander [VNIIEF; Kondratov, Sergey [VNIIEF; Razinkov, Sergey [VNIIEF

    2010-01-01

    Testing and demonstration of any radiation measurement system requires the use of appropriate radioactive sources. The AVNG implementation that we describe is an attribute measurement system built by RFNC - VNIIEF in Sarov, Russia. The AVNG detects neutron and gamma radiation signatures and displays the three unclassified attributes of 'plutonium presence,' 'plutonium mass > 2 kg,' and 'plutonium isotopic ratio ({sup 240}Pu to {sup 239}Pu) < 0.1.' The AVNG was tested using a number of reference material (RM) sources with masses and isotopic ratios above and below these thresholds. The AVNG was demonstrated in June 2009 using several of these sources in addition to detector calibration sources. Since the AVNG was designed to measure multi-kg plutonium sources, the RM was manufactured specifically for use with this system. In addition, the RM was used to test the thresholds in the AVNG, so the size and composition of each RM was certified prior to use. In this presentation, we will describe the various steps in the manufacture and certification of these RM sources.

  3. Reference material manufacture and certification for the AVNG

    International Nuclear Information System (INIS)

    Testing and demonstration of any radiation measurement system requires the use of appropriate radioactive sources. An attribute measurement system (A VNG) was developed and fabricated at the Russian Federal Nuclear Center, VNIIEF, Russia, under contract with LANL, USA. The A VNG detects neutron and gamma radiation signatures and compares the data analysis results with the specified threshold values for three unclassified attributes; plutonium is present or absent, plutonium mass is greater than or less than the specified threshold value and plutonium isotopic ratio 240Pu to 239Pu) is greater than or less then the threshold value. A set of reference materials (RMs) was specially manufactured for the A VNG with masses and isotopic ratios above and below the selected thresholds. The set of RMs was certified in compliance with the Russian metrological requirements. The RMs were used to debug and test the A VNG and to demonstrate the A VNG operation to an American delegation in June 2009. In this presentation, we will describe the various steps in the manufacture and certification of these RM sources.

  4. Flouescence reference materials used for optical and biophotonic applications

    Science.gov (United States)

    Engel, A.; Otterman, C.; Klahn, J.; Enseling, D.; Korb, T.; Resch-Genger, U.; Hoffmann, K.; Schweizer, S.; Selling, J.; Kynast, U.; Koberling, F.; Rupertus, V.

    2007-07-01

    Fluorescence techniques are known for their high sensitivity and are widely used as analytical tools and detection methods for product and process control, material sciences, environmental and bio-technical analysis, molecular genetics, cell biology, medical diagnostics, and drug screening. According to DIN/ISO 17025 certified standards are used for fluorescence diagnostics having the drawback of giving relative values for fluorescence intensities only. Therefore reference materials for a quantitative characterization have to be related directly to the materials under investigation. In order to evaluate these figures it is necessary to calculate absolute numbers like absorption/excitation cross sections and quantum yield. This can be done for different types of dopands in different materials like glass, glass ceramics, crystals or nano crystalline material embedded in polymer matrices. Based on the optical spectroscopy data we will discuss options for characteristic doped glasses and glass ceramics with respect to scattering and absorption regime. It has shown recently for YAG:Ce glass ceramics that for a proper determination of the quantum efficiency in these highly scattering media a reference material with similar scattering and fluorescent properties is required. This may be performed using the emission decay measurement diagnostics, where the decay time is below 100 ns. In this paper we present first results of these aspects using well performing LUMOGEN RED organic pigments for a comparison of mainly transparent glass with glass ceramics doped with various amounts of dopands e.g. ions of raw earth elements and transition metals. The LUMOGEN red is embedded in silica and polyurethane matrices. Characterisations on wavelength accuracy and lifetime for different environmental conditions (temperature, UV irradiation) have been performed. Moreover intensity patterns and results for homogeneity, isotropy, photo and thermal stability will be discussed. In a next

  5. Certification of the uranium hexafluoride reference materials for isotopic composition

    OpenAIRE

    MIALLE SÉBASTIEN; Richter, Stephan; HENNESSY Carmel; TRUYENS Jan; Jakobsson, Ulf; Aregbe, Yetunde

    2014-01-01

    The IRMM-019 to IRMM-029 series of uranium hexafluoride materials is certified for the isotopic composition. After conversion into uranyl nitrate solution, certification and homogeneity measurements were performed by Thermal Ionization Mass Spectrometry. Analyses were performed by Modified Total Evaporation and for some materials the major isotope amount ratio n(235U)/n(238U) was measured using a n(233U)/n(236U) double spike. Measurements were confirmed by UF6 Gas Source Mass Spectrometry. Ma...

  6. Reference material for natural radionuclides in glass designed for underground experiments

    International Nuclear Information System (INIS)

    A reference material designed for the determination of natural radionuclides in solid samples (glass pellets) is described and the results of certification are presented. The material has been certified for 7 natural radionuclides (40K, 226Ra, 228Ra, 228Th, 232Th, 235U and 238U). An information value is given for 210Pb. Radon (222Rn) emanation experiments showed results comparable within participating laboratories, however, the number of data and precision was too low to carry out a certification process. The reference material may be used for quality management of analytical laboratories engaged in the high-sensitive analysis of radionuclides in the construction materials of detectors placed in ultra low background underground laboratories. (author)

  7. Reference material for natural radionuclides in glass designed for underground experiments

    CERN Document Server

    Povinec, P P; Busto, J; Cerna, C; Degering, D; Hamajima, Y; Holy, K; Hult, M; Jeskovsky, M; Koehler, M; Kovacik, A; Laubenstein, M; Loaiza, P; Mamedov, F; Marquet, C; Mott, J; Mullerova, M; Perrot, F; Piquemal, F; Reyss, J -L; Saakyan, R; Simgen, H; Soule, B; Stanicek, J; Sykora, I; Stekl, I

    2015-01-01

    A reference material designed for the determination of natural radionuclides in solid samples (glass pellets) is described and the results of certification are presented. The material has been certified for 7 natural radionuclides (40K, 226Ra, 228Ra, 228Th, 232Th, 235U and 238U). An information value is given for 210Pb. Radon (222Rn) emanation experiments showed results comparable within participating laboratories, however, the number of data and precision was too low to carry out a certification process. The reference material may be used for quality management of analytical laboratories engaged in the high-sensitive analysis of radionuclides in the construction materials of detectors placed in ultra low background underground laboratories.

  8. Candidate coffee reference material for element content: production and certification schemes adopted at CENA/USP

    Energy Technology Data Exchange (ETDEWEB)

    Tagliaferro, Fabio Sileno; Fernandes, Elisabete A. de Nadai; Bacchi, Marcio Arruda; Franca, Elvis Joacir de [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil). Lab. de Radioisotopos], e-mail: fabiotag@cena.usp.br, e-mail: lis@cena.usp.br, e-mail: mabacchi@cena.usp.br, e-mail: ejfranca@cena.usp.br; Bode, Peter; Bacchi, Marcio Arruda; Franca, Elvis Joacir de [Delft University of Technology, Delft (Netherlands). Interfaculty Reactor Inst.], e-mail: P.Bode@iri.tudelft.nl

    2003-07-01

    Certified reference materials (CRMs) play a fundamental role in analytical chemistry establishing the traceability of measurement results and assuring accuracy and reliability. In spite of the huge importance of measurements in the food sector, Brazil does not produce CRMs to supply the demand. Consequently the acquisition of CRMs depends on imports at high costs. The coffee sector needs CRMs, however there is no material that represents the coffee composition. Since 1998, the Laboratorio de Radioisotopos (LRi) of CENA/USP has been involved in analysis of coffee. During this period, knowledge has been accumulated about several aspects of coffee, such as system of cultivation, elemental composition, homogeneity of the material, possible contaminants and physical properties of beans. Concomitantly, LRi has concentrated efforts in the field of metrology in chemistry, and now all this expertise is being used as the basis for the production of a coffee certified reference material (CRM) for inorganic element content. The scheme developed for the preparation and certification of coffee RM relies on the ISO Guides 34 and 35. The approaches for selection, collection and preparation of the material, moisture determination method, homogeneity testing, certification and long-term stability testing are discussed and a time frame for the expected accomplishments is provided. (author)

  9. Proposals for the use of reference materials and for the development of in-house quality control materials for food analysis

    International Nuclear Information System (INIS)

    A summary is presented of factors to be considered in the development of food-based in-house quality control materials to augment available Reference Materials and for frequent, concerted data quality control. Some guidelines are offered regarding approaches to the many considerations required for such an endeavour. Preliminary draft recommendations containing a sequence of steps has been compiled as a starting proposal for a food quality control material development scheme, for a range of natural matrices and measurands. In addition, information on the selection and utilization of Certified Reference Materials and procedures for performance interpretation and corrective action is provided. (author)

  10. Anorganic fluorescence reference materials for decay time of fluorescence emission

    Science.gov (United States)

    Engel, A.; Ottermann, C.; Klahn, J.; Korb, T.; Resch-Genger, U.; Hoffmann, K.; Kynast, U.; Rupertus, V.

    2008-02-01

    Fluorescence techniques are known for their high sensitivity and are widely used as analytical tools, detection methods and imaging applications for product and process control, material sciences, environmental and bio-technical analysis, molecular genetics, cell biology, medical diagnostics, and drug screening. According to DIN/ISO 17025 certified standards are used for steady state fluorescence diagnostics, a method having the drawback of giving relative values for fluorescence intensities only. Therefore reference materials for a quantitative characterization have to be related directly to the materials under investigation. In order to evaluate these figures it is necessary to calculate absolute numbers such as absorption/excitation cross sections and quantum yield. This has been done for different types of dopands in different materials such as glass, glass ceramics, crystals or nano crystalline material embedded in polymer matrices. Samples doped with several fluophores of different emission wavelengths and decay times are required for fluorescent multiplexing applications. Decay times shorter than 100 ns are of special interest. In addition, a proper knowledge is necessary of quantum efficiency in highly scattering media. Recently, quantum efficiency in YAG:Ce glass ceramics has been successfully investigated. Glass and glass ceramics doped with threefold charged rare earth elements are available. However, these samples have the disadvantage of emission decay times much longer than 1 microsecond, due to the excitation and emission of their optical forbidden electronic transitions. Therefore first attempts have been made to produce decay-time standards based on organic and inorganic fluophores. Stable LUMOGEN RED pigments and YAG:Ce phosphors are diluted simultaneously in silicone matrices using a wide range of concentrations between 0.0001 and 2 wt%. Organic LUMOGEN RED has decay times in the lower nanosecond range with a slight dependency on concentration

  11. 用于早前寒武纪岩石Ar-Ar法定年的K-Ar法年龄国家二级标准物质——ZMT04白云母的定值结果%The certified results of ZMT04 muscovite reference material utilized for 40Ar/39Ar isotopic geochronological research on Early precambrian rocks in China.

    Institute of Scientific and Technical Information of China (English)

    桑海清; 王非; 龚俊峰; 周晶

    2013-01-01

    desirable for any relatively old sample.In that occasion,if the neutron flux monitor is much younger than the unknown age sample,the 40 Ar/39Ar ratio in standard may become very small,approaching a smaller limit value (≈3).Therefore,it is quite necessary to prepare an old age standard for the flux monitor of the 40 Ar-39 Ar method,especially for isotopic geochronological research on Early Precambrian rocks and meteorites.ZMT04 muscovite as K-Ar age geostandard of China,were separated from a pegmatite dike which occurs at Tianpishan area,in the southwest of Zhuozi County,Inner Mongolia of China.The pegmatite consists of muscovite,quartz and minor zircon,sphere etc.About 1080g of pure ZMT04 muscovite was obtained at the (10 × 1 × 0.02)mm fraction.The purity is about 100%.Following mixing,the ZMT04 muscovite was divided into 14 jars about 77g each.Each jar sample was further subdivided into14 aliquots about 5.51g each (total 196 aliquots).One aliquot (prefixed C) was retained for control analysis of K and 40Ar*,the other 13 aliquot of the same jar remain to be used fo interlabortory work.40Ar-39 Ar age spectrum of ZMT04 muscovite indicats that the muscovite has remained undisturbed since its crystallisation.The plateau age age is 1823 ± 15Ma.Thirteen stepwise hating Ar isotopic data of the muscovite give a 40Ar/39Ar isochron age of 1824 ± 15Ma and the initial 40Ar/36Ar ration of 288 ± 16,and the MSWD in the 40Ar/36Ar-39Ar/36Ar isochron diagram is 2.10.This age may represent the crystallization time of the muscovite in the pegmatite dike.The homogeneity tests and the certification analyses of 40Ar* and K in ZMT04 muscovite were performed according to the rules from the International Standard Organization (ISO) Guid 35 (1985) and primary referenc material technique of China (1994).During the homogeneity tests the analyses of K and 40Ar* in 77-600 hornblende,Hb3gr hornblende and BSP-1 hornblend were done and the results are almost coincident with their mean value

  12. An outline of reference materials for analysis techniques in China

    International Nuclear Information System (INIS)

    This paper provides background information on the development in the field of reference materials in China. The major considerations in development of reference materials include homogeneity, stability, handling procedures and certification. Further it discusses the plans for development in the near future specific natural-matrix reference materials containing low levels of trace elements and having high degree of homogeneity

  13. Report of the 2nd research co-ordination meeting on reference materials for microanalytical nuclear techniques

    International Nuclear Information System (INIS)

    Many microanalytical procedure require specific natural-matrix reference materials containing very low levels of trace elements and having a high degree of homogeneity. This proposed CRP will specifically address the question of quality control materials for these techniques. The participants of the meeting discussed the requirements for certified reference materials to by used in microanalysis with particular emphasis on the homogeneity issues. This publication contains summary of the discussions along with conclusions and recommendations made by the participants. The publication also contains ten individual presentations delivered by the participants. Each of the individual papers has been provided with an abstract and indexed separately

  14. Preparation and certification of the Polish reference material Virginia Tobacco Leaves (CTA-VTL-2) for inorganic trace analysis including microanalysis

    Energy Technology Data Exchange (ETDEWEB)

    Dybczynski, R.; Polkowska-Motrenko, H.; Samczynski, Z.; Szopa, Z.

    1997-12-31

    A new Polish certified reference material Virginia Tobacco Leaves (CTA-VTL-2) for inorganic trace analysis including microanalysis has been prepared. Certification of the candidate reference material was based on the world-wide interlaboratory comparison in which 60 laboratories from 18 countries, participated using various analytical methods and techniques. Data evaluation performed by means of the new multifunctional software package -SSQC. Recommended values were assigned for 33 and `information` values for 10 elements, respectively. The validity of `certified` values was confirmed for several elements using `very accurate` methods developed in this Laboratory. (author). 47 refs, 28 figs, 12 tabs.

  15. Material control system simulator program reference manual

    Energy Technology Data Exchange (ETDEWEB)

    Hollstien, R.B.

    1978-01-24

    A description is presented of a Material Control System Simulator (MCSS) program for determination of material accounting uncertainty and system response to particular adversary action sequences that constitute plausible material diversion attempts. The program is intended for use in situations where randomness, uncertainty, or interaction of adversary actions and material control system components make it difficult to assess safeguards effectiveness against particular material diversion attempts. Although MCSS may be used independently in the design or analysis of material handling and processing systems, it has been tailored toward the determination of material accountability and the response of material control systems to adversary action sequences.

  16. 40 CFR 90.7 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA Air and Radiation... 19103. Document number and name 40 CFR part 90 reference ASTM D86-93: Standard Test Method for...., Warrendale, PA 15096-0001. Document number and name 40 CFR part 90 reference SAE J1930 September...

  17. Element content and particle size characterization of a mussel candidate reference material

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, Edson G.; Vasconcellos, Marina B.A., E-mail: emoreira@ipen.b, E-mail: mbvascon@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro do Reator de Pesquisas; Santos, Rafaela G. dos; Martinelli, Jose R., E-mail: jroberto@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Ciencias e Tecnologia de Materiais

    2011-07-01

    The use of certified reference materials is an important tool in the quality assurance of analytical measurements. To assure reliability on recently prepared powder reference materials, not only the characterization of the property values of interest and their corresponding uncertainties, but also physical properties such as the particle size distribution must be well evaluated. Narrow particle size distributions are preferable than larger ones; as different size particles may have different analyte content. Due to this fact, the segregation of the coarse and the fine particles in a bottle may lead to inhomogeneity of the reference material, which should be avoided. In this study the element content as well as the particle size distribution of a mussel candidate reference material produced at IPEN-CNEN/SP was investigated. Instrumental Neutron Activation Analysis was applied to the determination of 15 elements in seven fractions of the material with different particle size distributions. Subsamples of the materials were irradiated simultaneously with elemental standards at the IEA-R1 research nuclear reactor and the induced gamma ray energies were measured in a hyperpure germanium detector. Three vials of the candidate reference material and three coarser fractions, collected during the preparation, were analyzed by Laser Diffraction Particle Analysis to determine the particle size distribution. Differences on element content were detected for fractions with different particle size distribution, indicating the importance of particle size control for biological reference materials. From the particle size analysis, Gaussian particle size distribution was observed for the candidate reference material with mean particle size {mu} = 94.6 {+-} 0.8 {mu}m. (author)

  18. 40 CFR 1065.1010 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... Federal Register approved the incorporation by reference as prescribed in 5 U.S.C. 552(a) and 1 CFR part... of the International System of Units (SI), Barry N. Taylor, Physics Laboratory 1065.20,...

  19. 40 CFR 89.6 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at US EPA, OAR, 1200 Pennsylvania Ave... 19428-2959. Document number and name 40 CFR part 89 reference ASTM D86-97: “Standard Test Method for... Commonwealth Dr., Warrendale, PA 15096-0001. Document number and name 40 CFR part 89 reference SAE J244 June...

  20. Development of Reference Materials for Thermal-Diffusivity Measurements by the Flash Method

    Science.gov (United States)

    Akoshima, M.; Abe, H.; Baba, T.

    2015-12-01

    The thermal conductivity of solid materials used for thermal simulations and thermal designs can be obtained as the product of thermal diffusivity, specific heat capacity, and bulk density in many cases. The thermal diffusivity is usually measured by the flash method, and the specific heat capacity is usually measured by differential scanning calorimetry. In order to obtain reliable thermal conductivities for strict thermal design, it is necessary to measure the thermal diffusivity using the flash method, a well-validated apparatus. Reference materials are an effective means for validation of most practical measurement apparatus. For the flash method, isotropic graphite was selected as a candidate reference material. A batch of isotropic graphite samples was prepared and characterized in detail in order to be a certified reference material for thermal-diffusivity measurement. The detailed characterization ensures the traceability of the measurement results to the international system of units (SI). A convenient reference material for thermal conductivity was also obtained by using the known thermal-diffusivity measurements, specific heat capacity, and density of the material.

  1. Prompt gamma activation analysis of boron in reference materials using diffracted polychromatic neutron beam

    International Nuclear Information System (INIS)

    Boron concentrations were analyzed for standard reference materials by prompt gamma activation analysis (PGAA). The measurements were performed at the SNU-KAERI PGAA facility installed at Hanaro, the research reactor of Korea Atomic Energy Research Institute (KAERI). The facility uses a diffracted polychromatic beam with a neutron flux of 7.9 x 107 n/cm2 s. Elemental sensitivity for boron was calibrated from the prompt gamma-ray spectra of boric acid samples containing 2-45 μg boron. The sensitivity of 2131 cps/mg-B was obtained from the linearity of the boron peak count rate versus the boron mass. The detection limit for boron was estimated to be 67 ng from an empty sample bag spectrum for a counting time of 10,000 s. The measured boron concentrations for standard reference materials showed good consistency with the certified or information values

  2. Prompt gamma activation analysis of boron in reference materials using diffracted polychromatic neutron beam

    Science.gov (United States)

    Byun, S. H.; Sun, G. M.; Choi, H. D.

    2004-01-01

    Boron concentrations were analyzed for standard reference materials by prompt gamma activation analysis (PGAA). The measurements were performed at the SNU-KAERI PGAA facility installed at Hanaro, the research reactor of Korea Atomic Energy Research Institute (KAERI). The facility uses a diffracted polychromatic beam with a neutron flux of 7.9 × 10 7 n/cm 2 s. Elemental sensitivity for boron was calibrated from the prompt gamma-ray spectra of boric acid samples containing 2-45 μg boron. The sensitivity of 2131 cps/mg-B was obtained from the linearity of the boron peak count rate versus the boron mass. The detection limit for boron was estimated to be 67 ng from an empty sample bag spectrum for a counting time of 10,000 s. The measured boron concentrations for standard reference materials showed good consistency with the certified or information values.

  3. Multielement analysis of environmental reference materials by instrumental neutron activation analysis

    International Nuclear Information System (INIS)

    Concentrations of trace elements in environmental reference materials prepared by the National Institute for Environmental Studies, Japan (NIES) and by the National Institute of Standards and Technology, USA (NIST) were determined by instrumental neutron activation analysis (INAA). NIES CRM No. 5 Human Hair, No. 6 Mussel, No. 7 Tea Leaves, No. 8 Vehicle Exhaust Particulates, No. 9 Sargasso and No. 10 Rice Flour-unpolished samples (ca. 150 - 1200 mg) and NIST SRM 1632a Bituminous Coal, SRM 1635 Sub-bituminous Coal and SRM 1633a Coal Fly Ash samples (ca. 10 - 150 mg) were irradiated at the Musashi Institute of Technology Research Reactor (MITRR). Concentrations of 28 - 52 elements in these NIES and NIST environmental reference materials were determined by two irradiation methods and four γ-ray counting methods. The determined values were in good agreement with the NIES and NIST certified values. (author)

  4. Caracterização detalhada de material de referência certificado de carvão brasileiro

    OpenAIRE

    Vera L. V. Fallavena; Cristiane S. de Abreu; Taísi D. Inácio; Marçal Pires; Carla M. N. Azevedo; Iolanda D. Fernandes; Lizete S. Ferret; M. Rosa Martinez Tarazona

    2013-01-01

    The use and characterization of the first Certified Reference Material (CRM) of Brazilian coal for analytical quality control are presented. All results were determined within the limits of repeatability and reproducibility allowed under the standards. Notable among the characterization parameters was the mineral matter content (45.39%) obtained by an alternative procedure showing a low relative error (-2.1%) compared to the standard technique (low ashing temperature). The possible expanded a...

  5. Experience with certifying borated stainless steel as a shipping cask basket material

    Energy Technology Data Exchange (ETDEWEB)

    Abbott, D.G. (EG and G Idaho, Inc., Idaho Falls, ID (USA)); Nickell, R.E. (Applied Science and Technology, Inc., Poway, CA (USA))

    1990-01-01

    The original cask designs for a cask demonstration project featured fuel baskets constructed of borated stainless steel (bss) as a structural material. The project is intended to demonstrate casks that can be used for both shipping and storing spent nuclear fuel assemblies. The baskets were intended to maintain the fuel assemblies in a subcritical array for both normal and accident conditions. The Nuclear Regulatory Commission, however, judged bss to be unacceptable as a structural material. The cask designs were subsequently modified. The knowledge gained during this cask demonstration project may be applicable to development of bss as a basket material in future cask design. 6 refs., 2 figs., 2 tabs.

  6. Experience with certifying borated stainless steel as a shipping cask basket material

    Energy Technology Data Exchange (ETDEWEB)

    Abbott, D.G. [Idaho National Engineering Lab., Idaho Falls, ID (United States); Nickell, R.E. [Applied Science and Technology, Poway, CA (United States)

    1990-10-01

    This paper discusses the original cask designs for a cask demonstration project that has featured fuel baskets constructed of borated stainless steel (bss) as a structural material. The project is intended to demonstrate casks that can be used for both shipping and storing spent nuclear fuel assemblies. The baskets were intended to maintain the fuel assemblies in a subcritical array for both normal and accident conditions. The Nuclear Regulatory Commission, judged bss to be unacceptable as a structural material. The cask designs were subsequently modified. The knowledge gained during this cask demonstration project may be applicable to development of bss as a basket material in future cask design.

  7. Corrosion reference for geothermal downhole materials selection

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, P.F. II, Smith, C.C.; Keeney, R.C.; Kirk, D.K.; Conover, M.F.

    1983-03-01

    Geothermal downhole conditions that may affect the performance and reliability of selected materials and components used in the drilling, completion, logging, and production of geothermal wells are reviewed. The results of specific research and development efforts aimed at improvement of materials and components for downhole contact with the hostile physicochemical conditions of the geothermal reservoir are discussed. Materials and components covered are tubular goods, stainless steels and non-ferrous metals for high-temperature downhole service, cements for high-temperature geothermal wells, high-temperature elastomers, drilling and completion tools, logging tools, and downhole pumps. (MHR)

  8. Testing the homogeneity of candidate reference materials by solid sampling - AAS and INAA

    International Nuclear Information System (INIS)

    The necessity to quantify a natural material's homogeneity with respect to its elemental distribution prior to chemical analysis of a given aliquot is emphasised. Available instruments and methods to obtain the relevant information are described. Additionally the calculation of element specific, relative homogeneity factors, HE, and of a minimum sample mass M5% to achieve 5% precision on a 95% confidence level is given. Especially, in the production and certification of Certified Reference Materials (CRMs) this characteristic information should be determined in order to provide the user with additional inherent properties of the CRM to enable more economical use of the expensive material and to evaluate further systematic bias of the applied analytical technique. (author)

  9. Analysis of FDA in-house food reference materials with anticoincidence INAA

    International Nuclear Information System (INIS)

    In-house reference material (IRM) cocoa powder (CCP) has been in use at US Food and Drug Administration laboratories for about 15 years. A single lot of commercial material was originally characterized for 32 elements by several laboratories and five techniques. A unique approach for basis weight determination based upon ambient relative humidity was developed for CCP, eliminating the need for dry weight determinations. The CCP Reference Sheet is updated by incorporating new results approximately every 5 years. The last update occurred in 2006. As part of an effort to revalidate and update values for CCP, anticoincidence instrumental neutron activation analysis (INAA) was used to determine mass fractions for 16 of the originally characterized elements, as well as to provide information on 16 other elements. Results were in very good agreement with 2006 Reference Sheet values. A new candidate IRM, fresh-frozen swordfish (FFSF) powder, was produced by adding inorganic As, Cd, Cr, Hg, Pb, Sb, and Se to liquid nitrogen-frozen commercial swordfish filets which were then homogenized. Portions of FFSF were analyzed by INAA to provide mass fraction and homogeneity information for As, Cd, Cr, Hg, Sb, and Se as well as for eight other elements occurring naturally in the material. Non-homogeneities were ≤2.5 % for As, Br, Cd, and Cs, and ≤1.8 % for Cr, Hg, Rb, Sb, and Se. Certified reference materials DORM-3 Fish Protein powder and fresh-frozen SRM 1947 Lake Michigan Fish Tissue were analyzed as controls. (author)

  10. Survey of currently available reference materials for use in connection with the determination of trace elements in biological and environmental materials

    International Nuclear Information System (INIS)

    This report focuses on analytical reference materials which have been developed for use in connection with the determination of toxic and essential trace elements in biomedical and health-related environmental samples. Data are reported on 60 biological and 40 environmental (non-biological) reference materials from 11 suppliers. Certified concentration values (or their equivalents) and non-certified concentration values (or information values) are presented in various tables which are intended to help the user select a reference material that matches as closely as possible (i.e. with respect to matrix type and concentration of the element of interest) the ''real'' samples that are to be analysed. These tables have been generated from a database characterized by the following parameters: total number of reference materials=100; total number of elements recorded=69; total number of concentration values recorded=1771. Also included in the report is information (where available) on the cost of each material, the unit weight or volume supplied, and the minimum weight of material recommended for analysis. (author)

  11. 40 CFR 86.1 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ....C. 552(a) and 1 CFR part 51. To enforce any edition other than that specified in this section, a... Chromatography, 1994 SAE Handbook—SAE International Cooperative Engineering Program, Volume 1: Materials, Fuels....094-8, 86.096-8. (iii) SAE J1850, July 1995, Class B Data Communication Network Interface,...

  12. Standard and reference materials for marine science, revised edition, 1993

    OpenAIRE

    IOC for UNESCO

    1993-01-01

    This is the third edition of the catalog of reference materials suited for use in marine science, originally compiled in 1986 for NOAA, IOC and UNEP. The catalog lists close to 2,000 reference materials from sixteen producers and contains information about their proper use, sources, availability, and analyte concentrations. Indices are included for elements, isotopes, and organic compounds, as are cross references to CAS registry numbers, alternate names, and chemical structures of selected o...

  13. [Review of normal spectral emissivity standard reference materials].

    Science.gov (United States)

    Yu, Kun; Liu, Yu-Fang; Zhao, Yue-Jin

    2012-11-01

    In order to improve the accuracy of spectral emissivity measurement, standard reference materials of spectral emissivity as the dissemination of quantity in spectral emissivity measurement are used for the calibration of spectral emissivity measurement apparatus. In the present paper, firstly the standard reference materials data proposed by the American National Institute of Standards and Technology are introduced, and some underlying standard reference materials suggested by some metering departments in Europe are analyzed in detail For the standard reference material Armco iron and SiC proposed by some researchers, the advantages and disadvantages were explored. Finally, the characteristics of standard reference materials are summarized, and the future development of spectral emissivity measurement standard is prospected.

  14. [Review of normal spectral emissivity standard reference materials].

    Science.gov (United States)

    Yu, Kun; Liu, Yu-Fang; Zhao, Yue-Jin

    2012-11-01

    In order to improve the accuracy of spectral emissivity measurement, standard reference materials of spectral emissivity as the dissemination of quantity in spectral emissivity measurement are used for the calibration of spectral emissivity measurement apparatus. In the present paper, firstly the standard reference materials data proposed by the American National Institute of Standards and Technology are introduced, and some underlying standard reference materials suggested by some metering departments in Europe are analyzed in detail For the standard reference material Armco iron and SiC proposed by some researchers, the advantages and disadvantages were explored. Finally, the characteristics of standard reference materials are summarized, and the future development of spectral emissivity measurement standard is prospected. PMID:23387148

  15. Phosphated minerals to be used as radioactive reference materials; Minerais fosfatados para serem utilizados como materiais de referencia radioativos

    Energy Technology Data Exchange (ETDEWEB)

    Braganca, M.J.C.S.; Tauhata, L. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Lab. Nacional de Metrologia das Radiacoes Ionizantes (LNMRI); Clain, A.F. [Universidade Severino Sombra, Vassouras, RJ (Brazil); Moreira, I. [Pontificia Univ. Catolica do Rio de Janeiro (PUC/Rio), RJ (Brazil). Dept. de Quimica

    2003-07-01

    The production and the supplying of certified reference materials, or deliberated contaminated materials containing natural radionuclides for laboratories which analyses environmental samples are fundamentals for the correct measurements of their radioactive levels. This analysis quality represents a important step for the safeguards of the population health, and quality control of the imported and exported products, such as minerals, agricultural and raw materials. The phosphate rocks, containing significant concentrations of thorium, and used as raw material and fertilizers justified a study for better characterization and distinction to be used cas certified reference radioactive materials. Therefore, samples from the two carboanalytical-alkaline chimneys (Araxa and Catalao), and one from metasedimentar origin (Patos de Minas), distant 100 km from each other, were collected and chemical and cholecystographic characterized by optical emission, X-ray diffraction and fluorescence. The element concentrations were determined by neutron activation analysis, ICP-MS and ICP-AES. The results, after multivariate statistical analysis and study of correlations among elements, have shown geochemical similarities of the phosphates from Araxa and Catalao, and differences from Patos de Minas, despite of the geographic proximity. The concentration of thorium between 200 and 500 (mg/g) allows to use such minerals as reference materials.

  16. Caracterização detalhada de material de referência certificado de carvão brasileiro

    Directory of Open Access Journals (Sweden)

    Vera L. V. Fallavena

    2013-01-01

    Full Text Available The use and characterization of the first Certified Reference Material (CRM of Brazilian coal for analytical quality control are presented. All results were determined within the limits of repeatability and reproducibility allowed under the standards. Notable among the characterization parameters was the mineral matter content (45.39% obtained by an alternative procedure showing a low relative error (-2.1% compared to the standard technique (low ashing temperature. The possible expanded application of this CRM application in national laboratories, beyond the certificated and reference parameters, has advantages such as lower cost and easy availability, but round robin tests must be performed.

  17. Implementation of Certified EHR, Patient Portal, and "Direct" Messaging Technology in a Radiology Environment Enhances Communication of Radiology Results to Both Referring Physicians and Patients.

    Science.gov (United States)

    Reicher, Joshua Jay; Reicher, Murray Aaron

    2016-06-01

    Since 2009, the Federal government distributed over $29 billion to providers who were adopting compliant electronic health record (EHR) technology. With a focus on radiology, we explore how EHR technology impacts interoperability with referring clinicians' EHRs and patient engagement. We also discuss the high-level details of contributing supporting frameworks, specifically Direct messaging and health information service provider (HISP) technology. We characterized Direct messaging, a secure e-mail-like protocol built to allow exchange of encrypted health information online, and the new supporting HISP infrastructure. Statistics related to both the testing and active use of this framework were obtained from DirectTrust.org, an organization whose framework supports Direct messaging use by healthcare organizations. To evaluate patient engagement, we obtained usage data from a radiology-centric patient portal between 2014 and 2015, which in some cases included access to radiology reports. Statistics from 2013 to 2015 showed a rise in issued secure Direct addresses from 8724 to 752,496; a rise in the number of participating healthcare organizations from 667 to 39,751; and a rise in the secure messages sent from 122,842 to 27,316,438. Regarding patient engagement, an average of 234,679 patients per month were provided portal access, with 86,400 patients per month given access to radiology reports. Availability of radiology reports online was strongly associated with increased system usage, with a likelihood ratio of 2.63. The use of certified EHR technology and Direct messaging in the practice of radiology allows for the communication of patient information and radiology results with referring clinicians and increases patient use of patient portal technology, supporting bidirectional radiologist-patient communication. PMID:26588906

  18. Preparation and certification of hijiki reference material, NMIJ CRM 7405-a, from the edible marine algae hijiki (Hizikia fusiforme).

    Science.gov (United States)

    Narukawa, Tomohiro; Inagaki, Kazumi; Zhu, Yanbei; Kuroiwa, Takayoshi; Narushima, Izumi; Chiba, Koichi; Hioki, Akiharu

    2012-02-01

    A certified reference material, NMIJ CRM 7405-a, for the determination of trace elements and As(V) in algae was developed from the edible marine hijiki (Hizikia fusiforme) and certified by the National Metrology Institute of Japan (NMIJ), the National Institute of Advanced Industrial Science and Technology (AIST). Hijiki was collected from the Pacific coast in the Kanto area of Japan, and was washed, dried, powdered, and homogenized. The hijiki powder was placed in 400 bottles (ca. 20 g each). The concentrations of 18 trace elements and As(V) were determined by two to four independent analytical techniques, including (ID)ICP-(HR)MS, ICP-OES, GFAAS, and HPLC-ICP-MS using calibration solutions prepared from the elemental standard solution of Japan calibration service system (JCSS) and the NMIJ CRM As(V) solution, and whose concentrations are certified and SI traceable. The uncertainties of all the measurements and preparation procedures were evaluated. The values of 18 trace elements and As(V) in the CRM were certified with uncertainty (k = 2).

  19. Standard guide for preparation of working reference materials for use in analysis of nuclear fuel cycle materials

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2001-01-01

    1.1 This guide covers the preparation and characterization of working reference materials (WRM) that are produced by a laboratory for its own use in the analysis of nuclear materials. Guidance is provided for establishing traceability of WRMs to certified reference materials by a defined characterization process. The guidance provided is generic; it is not specific for a given material. 1.2 The information provided by this guide is found in the following sections: Section Planning 6 Preparation 7 Packaging and Storage 8 Characterization 9 Statistical Analysis 10 Documentation 11 1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  20. Selective arsenic speciation analysis of human urine reference materials using gradient elution ion-exchange HPLC-ICP-MS

    DEFF Research Database (Denmark)

    Sloth, Jens Jørgen; Larsen, Erik Huusfeldt; Julshamn, K.

    2004-01-01

    Arsenic speciation analysis was performed in two human urine certified reference materials (NIES No. 18 and NIST SRM2670a) and three human urine control materials (Seronorm, Medisafe and Lyphocheck). The samples were diluted 1 + 3 prior to analysis by gradient elution anion or cation exchange high...... and dimethylarsinoylethanol, were determined in the urines. Additionally, several unknown arsenicals were detected. This is the first time that dimethylarsinoylacetic acid and trimethylarsoniopropionate have been reported in human urine. The sums of the species concentrations determined by the chromatographic approaches were...

  1. The development of the first set of Brazilian reference materials for the petroleum sector; O desenvolvimento dos primeiros materiais de referencia nacionais para o setor de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Zucchini, Ricardo R. [Instituto de Pesquisas Tecnologicas (IPT), Sao Paulo, SP (Brazil). Agrupamento de Materiais de Referencia

    2004-07-01

    The petroleum sector uses a number of standardized tests to characterize raw materials and products. The development of in-company programs for assurance of measurement quality, the increasing need to demonstrate proficiency by means of certification schemes or by widely accepted metrological practices, have been promoting a more intensive use of certified reference materials, in calibration as well as in validation of measurement methods and also in order to show the qualification of the laboratories. In this paper it is presented the preparation, performed by IPT's Reference Materials Group, of the first set of reference materials specially developed considering the needs of the petroleum community. Briefly, are presented the identification of the demands from the users, selection of matrices, homogeneity tests and stability studies, and the certification of the new reference materials, which are four diesel fuel oils with certified sulfur contents and one material with flash point certified by TAG and Pensky-Martens methods. It is presented a summary of the certification process, performed by means of a combined effort of several professionals that are now working at laboratories of research institutions, refineries and other industries, universities, fuel monitoring facilities and in National Petroleum Agency. (author)

  2. 硅铝铁标准物质的研制%Development of reference materials of silicon-aluminium-iron

    Institute of Scientific and Technical Information of China (English)

    李凤超; 周振华; 周晨旭

    2011-01-01

    On the basis of the needs of reference materials of silicon-aluminum-iron in our country, two reference materials of silicon-aluminum-iron were prepared According to the requirements of technical standard of silicon-aluminum-iron alloy, the silicon-aluminum-iron alloy with different content and without air hole or impurities on surface was selected as raw materials. After removing outer skin and inclusions and serting, the samples were prepared in to block samples with diameter of 40-50 mm. Then, they were grinded to particles with size smaller than 2 mm by jaw crusher. After fully mixing, the samples were repeatedly grinded with sample preparation machine. All the samples were made to pass through 0.125 mm (120 grid) screen. The u-niformity and stability tests of prepared reference materials were performed. The results showed that the prepared reference material had good uniformity and stability. The characterisation analysis of three elements including silicon, aluminum and iron in reference material was performed by several laboratories. The analytical data were tested by Grubbs method, Cochran's theorem and Shapiro-wilks method. The results showed that the normality test values of prepared reference material were all higher than the value of 95 % confidence probability. The certified values exhibited normal distribution or approximately normal distribution.

  3. The development and evaluation of reference materials for food microbiology.

    NARCIS (Netherlands)

    in 't Veld, P.H.

    1998-01-01

    Since 1986 the National Institute of Public Health and the Environment (RIVM) has worked on the development and evaluation of microbiological reference materials (RMs) with support from the European Communities Bureau of Reference (BCR), now called Standards Measurement and Testing (SM&T). The RMs a

  4. Uranium Isotopic Ratio Measurements of U3O8 Reference Materials by Atom Probe Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Fahey, Albert J.; Perea, Daniel E.; Bartrand, Jonah AG; Arey, Bruce W.; Thevuthasan, Suntharampillai

    2016-01-01

    We report results of measurements of isotopic ratios obtained with atom probe tomography on U3O8 reference materials certified for their isotopic abundances of uranium. The results show good agreement with the certified values. High backgrounds due to tails from adjacent peaks complicate the measurement of the integrated peak areas as well as the fact that only oxides of uranium appear in the spectrum, the most intense of which is doubly charged. In addition, lack of knowledge of other instrumental parameters, such as the dead time, may bias the results. Isotopic ratio measurements can be performed at the nanometer-scale with the expectation of sensible results. The abundance sensitivity and mass resolving power of the mass spectrometer are not sufficient to compete with magnetic-sector instruments but are not far from measurements made by ToF-SIMS of other isotopic systems. The agreement of the major isotope ratios is more than sufficient to distinguish most anthropogenic compositions from natural.

  5. Development of botanical and fish oil standard reference materials for fatty acids.

    Science.gov (United States)

    Schantz, Michele M; Sander, Lane C; Sharpless, Katherine E; Wise, Stephen A; Yen, James H; NguyenPho, Agnes; Betz, Joseph M

    2013-05-01

    As part of a collaboration with the National Institutes of Health's Office of Dietary Supplements and the Food and Drug Administration's Center for Drug Evaluation and Research, the National Institute of Standards and Technology has developed Standard Reference Material (SRM) 3274 Botanical Oils Containing Omega-3 and Omega-6 Fatty Acids and SRM 3275 Omega-3 and Omega-6 Fatty Acids in Fish Oil. SRM 3274 consists of one ampoule of each of four seed oils (3274-1 Borage (Borago officinalis), 3274-2 Evening Primrose (Oenothera biennis), 3274-3 Flax (Linium usitatissimum), and 3274-4 Perilla (Perilla frutescens)), and SRM 3275 consists of two ampoules of each of three fish oils (3275-1 a concentrate high in docosahexaenoic acid, 3275-2 an anchovy oil high in docosahexaenoic acid and eicosapentaenoic acid, and 3275-3 a concentrate containing 60% long-chain omega-3 fatty acids). Each oil has certified and reference mass fraction values for up to 20 fatty acids. The fatty acid mass fraction values are based on results from analyses using gas chromatography with flame ionization detection (GC-FID) and mass spectrometry (GC/MS). These SRMs will complement other reference materials currently available with mass fractions for similar analytes and are part of a series of SRMs being developed for dietary supplements. PMID:23371533

  6. Evaluation of a reference material for glycated haemoglobin

    NARCIS (Netherlands)

    Weykamp, CW; Penders, TJ; Muskiet, FAJ; vanderSlik, W

    1996-01-01

    The use of lyophilized blood as a reference material for glycated haemoglobin was investigated with respect to IFCC criteria for calibrators and control materials. Ninety-two laboratories, using 11 methods, detected no changes in glycated haemoglobin content when the lyophilizate was stored for one

  7. The preparation and certification of ten uranium reference materials

    International Nuclear Information System (INIS)

    This report describes the procedures involved in the preparation, analysis and certification of ten 'UREM' uranium-bearing materials for use as international reference materials. Recommended values for total U3O8 are assigned to all of the ten materials. Twenty-two laboratories from seven countries contributed a total of approximately 300 analytical results for each material. The analytical methods used were X-ray-fluorescence spectrometry, colorimetry, fluorimetry, neutron-activation analysis, and emission spectroscopy using an inductively coupled plasma source. Approximately 300 kg of each reference material was prepared, primarily for use by the South African uranium industry. However, a limited amount of each material is available for overseas laboratories

  8. A new basaltic glass microanalytical reference material for multiple techniques

    Science.gov (United States)

    Wilson, Steve; Koenig, Alan; Lowers, Heather

    2012-01-01

    The U.S. Geological Survey (USGS) has been producing reference materials since the 1950s. Over 50 materials have been developed to cover bulk rock, sediment, and soils for the geological community. These materials are used globally in geochemistry, environmental, and analytical laboratories that perform bulk chemistry and/or microanalysis for instrument calibration and quality assurance testing. To answer the growing demand for higher spatial resolution and sensitivity, there is a need to create a new generation of microanalytical reference materials suitable for a variety of techniques, such as scanning electron microscopy/X-ray spectrometry (SEM/EDS), electron probe microanalysis (EPMA), laser ablation inductively coupled mass spectrometry (LA-ICP-MS), and secondary ion mass spectrometry (SIMS). As such, the microanalytical reference material (MRM) needs to be stable under the beam, be homogeneous at scales of better than 10–25 micrometers for the major to ultra-trace element level, and contain all of the analytes (elements or isotopes) of interest. Previous development of basaltic glasses intended for LA-ICP-MS has resulted in a synthetic basaltic matrix series of glasses (USGS GS-series) and a natural basalt series of glasses (BCR-1G, BHVO-2G, and NKT-1G). These materials have been useful for the LA-ICP-MS community but were not originally intended for use by the electron or ion beam community. A material developed from start to finish with intended use in multiple microanalytical instruments would be useful for inter-laboratory and inter-instrument platform comparisons. This article summarizes the experiments undertaken to produce a basalt glass reference material suitable for distribution as a multiple-technique round robin material. The goal of the analytical work presented here is to demonstrate that the elemental homogeneity of the new glass is acceptable for its use as a reference material. Because the round robin exercise is still underway, only

  9. Report of the consultants meeting on proper use of reference and control materials

    International Nuclear Information System (INIS)

    Quality control in analytical laboratories as a basis of a complete quality system needs still to be developed in many Member States. To support the dissemination of information in this field a consultants meeting on 'Proper Use of Reference and Quality Control Materials' was held at the IAEA Headquarters, Vienna, from 13 to 17 August 2001. The experts convened with the objective to prepare a TECDOC to advise analytical laboratories in Member States on the correct use of Certified Reference Materials (CRMs) for Quality Control purposes and give practical recommendations to expand this concept to in-house Quality Control Materials (QCMs). In view of the existing literature in this field an urgent need for a practical guidebook for the preparation and application of cost effective and matrix matching QCMs was identified and the experts tried to fill this gap from their relevant experience. One and a half days of lecturing was followed by intensive discussion and brain storming to create a list of key words, which were structured in a logical order to provide a frame for the projected document. Responsibilities were assigned and deadlines fixed for the submission of the full text. (author)

  10. The characterization of uranium and plutonium reference materials by the (100-X) route; basic principle and applications

    International Nuclear Information System (INIS)

    Uranium and plutonium reference materials are produced to calibrate reagents used in titrimetric methods or to check instrumental techniques like electrochemical methods. For this purpose, the most commonly prepared reference materials are high-purity uranium metal pieces and uranium dioxide pellets, respectively plutonium metal pieces and plutonium dioxide powders. Two different routes can be followed to certify the element content: a direct or an indirect route. With the direct route the main element is assayed using appropriate redox titration methods. The overall uncertainty on the main element is limited by both the precision of the titration methods used and the uncertainty of the reference materials. The indirect route is applicable only for high purity base material. It requires the measurement of the sum of impurities (X) in the material and the substraction of this sum from hundred per cent (100-X). Since the (100-X) route requires the measurement of a large number of elements, a variety of analytical methods has to be used, and a contribution by different specialized laboratories is requested. The uncertainty of the total of impurities is calculated from the respective uncertainties of the determination of each specific element. If the total of impurities is sufficiently small and even if it is determined with a rather large uncertainty, the (100-X) route leads nevertheless to a low uncertainty on the main element content. The application of the (100-X) route is illustrated for the case of uranium dioxide pellets certified as an European Community Nuclear Reference Material. The (100-X) route is recommended as a very accurate one for high purity material characterization and certification purposes

  11. Reference materials--a main element in a coherent reference measurement system.

    Science.gov (United States)

    Dybkaer, R

    1991-04-01

    The analytical reliability of any measurement procedure requires a specifically designed, coherent reference measurement system, including interrelated measurement procedures and measurement standards such as reference materials. The latter may be characterized by three sets of characteristics. The general characteristics comprise origin, mode of production, physical state and phase, homogeneity, physical form, container, additives, storage conditions, stability, and dangerous properties. The specific characteristics describe molecular composition, analyte, purity, matrix, quantity of interest (including scale), assigned value, and uncertainty of measurement. The additional characteristics concern the way in which values for other characteristics were obtained, the hierarchical position of the material, certificate, instructions for use, and intended function. The problem areas of reference materials comprise definition of the appropriate analyte, purification, matrix, assignment of values, and nomenclature. The present ambiguous terminology is presented and a systematic structure of descriptive names is proposed (tab. 1). PMID:1868129

  12. Determination of cadmium, lead and zinc in a candidate reference materials using isotope dilution mass spectrometry

    International Nuclear Information System (INIS)

    The growing demands placed on analytical laboratories to ensure the reliability of their results, due to the introduction of systems of quality and to the increasing use of metrology in chemical measurements has led most laboratories to validate their methodologies and to control them statistically. One of the techniques used most often for these purposes is based on the use of reference materials. The proper use of these materials means that laboratory results may be traced to the International System of Units, analytical methodologies can be validated, instruments calibrated and chemical measurements harmonized. One of the biggest challenges in developing reference materials is that of certifying their properties, a process that has been defined as assigning a concentration value that is as close as possible to the true value together with its uncertainty. Organizations that produce reference materials use several options for their certification process, and among these is the use of a primary method. Among the primary methods recognized by the International Office of Weights and Measures is the Isotope Dilution Mass Spectrometry technique. The Chilean Nuclear Energy Commission, through its Reference Materials Program, has prepared a reference material of clam tissue, which has been chemically defined by different analytical methodologies applied in different national and international laboratories. This work describes the methodology developed with the CIEMAT for determining the elements lead, cadmium and zinc in the clam tissue reference material using the primary technique of Isotope Dilution Mass Spectrometry. The calculation is described for obtaining the spike amounts to be added to the sample and the procedure is explained for carrying out the isotopic exchange. The isotopic relationships 204Pb/205Pb, 111Cd/114Cd and 66Zn/67Zn were determined in an atomic emission spectrometer with a plasma source with the following characteristics: plasma ionization

  13. SPOTS project and development of a standard and reference material

    Science.gov (United States)

    Burguete, R.; Patterson, E.

    2010-06-01

    The ‘Standardization Project for Optical Techniques of Strain measurement’ (SPOTS) was focused on the development of reference materials for calibrating optical systems for static strain measurement and standardized tests for evaluating the capabilities of such systems. The reference material consists of a beam in four-point bending within a monolithic frame that ensures reproducibility of the boundary and loading conditions. A procedure for the use of the reference material has been developed and leads to the evaluation of measurement uncertainties that allow the construction of confidence limits for the data obtained with the calibrated optical system. The design and methodology have been developed into a proposed draft standard which is being endorsed by VAMAS (Versailles Agreement on Materials And Standards) for review by ISO (International Standards Organisation). An overview of philosophy underpinning the proposed draft standard is presented and serves as an introduction to the reference material and standardized test and their use in providing higher confidence in optical measurements of strain.

  14. Determination of arsenic in food and dietary supplement standard reference materials by neutron activation analysis

    International Nuclear Information System (INIS)

    Arsenic was measured in food and dietary supplement standard reference materials by neutron activation analysis for the purpose of assigning certified or reference As mass fractions and to assess material homogeneity. Instrumental neutron activation analysis was used to value assign As in candidate SRM 3532 Calcium Dietary Supplement and candidate SRM 3262 Hypericum perforatum (St. John's Wort) Aerial Parts down to about 100 μg/kg. Values were also determined for two additional candidate St. John's Wort SRMs with As mass fractions 24Na and 82Br limited the reproducibility of the method below 100 μg/kg. For measurement of lower As mass fractions, a radiochemical neutron activation analysis method with extraction of As3+ into diethyl-dithiocarbamate in chloroform and detection limits down to 0.1 μg/kg. As was used to value-assign As mass fractions for SRM 3280 Multivitamin/Multielement Tablets and for candidate SRM 3233 Fortified Breakfast Cereal, and at <10 μg/kg in candidate SRM 1845a Whole Egg Powder. (author)

  15. Determination of copper, molybdenum and selenium in biological reference materials by inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    In a contribution to the elemental characterization of 10 new reference materials, Bovine Muscle Powder (136), Corn Starch (162), Hard Red Spring Wheat Flour (165), Soft Winter Wheat Flour (166), Whole Milk Powder (183), Wheat Gluten (184), Corn Bran (186). Durum Wheat Flour (187), Whole Egg Powder (188) and Microcrystalline Cellulose (189), the total concentrations of Cu, Mo and Se were determined by the application of an analytical method based on isotope dilution inductively coupled plasma mass spectrometry. Cu and Mo contents were quantified by measurement of 65Cu/63Cu and 97Mo/100Mo isotopic ratios following spiking with 65Cu and 97Mo and digestion with nitric acid. Selenium was separated as hydrogen selenide from the matrix using sodium borohydride after spiking with 82Se and acid digestion-dry ashing and quantified by measurement of the 82Se/78Se isotopic ratio. Comparison of these results with those from a variety of other methods and assessment of the procedures using certified reference materials indicated that the determinations of Cu, Mo and Se were performed without analytical bias. (orig.)

  16. Production and characterization of a bovine liver candidate reference material

    Science.gov (United States)

    Bianchi, S. R.; Peixoto, A. M. J.; Souza, G. B.; Tullio, R. R.; Nogueira, A. R. A.

    2016-07-01

    The preparation of a bovine liver candidate reference material and the steps are taken to confirm its homogeneity, long and short term stabilities, and consensus values are described. Details of the sample preparation and the final collaborative exercise are presented. The material elemental composition was characterized by 17 elements (As, Ca, Cd, Co, Cu, Fe, K, Mg, Mo, Mn, Na, P, Pb, Se, Sr, V, and Zn) of nutritional and toxicological significance.

  17. MICROCRM: Feasibility certification studies of microbiological reference materials

    NARCIS (Netherlands)

    Mooijman KA; Nagelkerke NJD; Demarquilly C; Lemdani M; Stewardson D; Fouweather T; Lightfoot N; Simonart T; MGB

    2004-01-01

    In 2002 feasibility certification studies were carried out on three different types of microbiological reference materials for eight different ISO and EN standard methods, related to EU water legislation (Drinking-water Directive and Bathing-water Directive). These studies were performed as part of

  18. Effects of Extraction Solvents on the Extraction Efficiencies of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans, and Polychlorinated Biphenyls in Reference Materials

    OpenAIRE

    KIGUCHI, Osamu; Kobayashi, Takashi; SAITOH, Katsumi

    2006-01-01

    This study investigated the extraction efficiency of a couple of different extraction solvents for Certified Reference Materials of soil and sediment that include Polychlorinated Dibenzo-p-dioxins and Dibenzofurans and Coplanar Polychlorinated Biphenyls using Soxhlet and Pressurized Liquid extraction (PLE). n-Hexane, toluene, acetone, acetone/n-hexane and acetone/toluene (1:1, v/v) as solvents were examined. Unsatisfactory results for Soxhlet extraction were obtained using n-hexane alone. For...

  19. Recommended reference materials for realization of physicochemical properties density

    CERN Document Server

    Herington, E F G

    1976-01-01

    This book first presents the nomenclature and units used in the determination of densities of liquids and solids, followed by a general description of the apparatus and the methods used in the measurement of density, with particular reference to the pycnometric, hydrostatic weighing, magnetic float, and temperature flotation methods. The use of water as a density reference material is then explained, focusing on the isotopic composition of Standard Mean Ocean Water (SMOW) and the absolute density of SMOW as a function of temperature. Problems due to the effect of pressure and dissolved gases o

  20. Developing Potential New Reference Materials for Light Isotopes in Foodstuffs

    Science.gov (United States)

    Frew, Russell; Van Hale, Robert; Clarke, Dianne; Abrahim, Aiman; Resch, Christian; Mayr, Leopold; Cannavan, Andrew; Gröning, Manfred

    2013-04-01

    Measurements of subtle variations in stable isotope ratios provide the means for verifying food integrity in numerous ways. Adulterants usually have different isotopic composition so their presence in a food is readily detectable. Stable isotope measurements can also be used to determine the region of production of the food. In most cases the ability of stable isotope measurements to verify, or otherwise reject, the authenticity of the food is greatly enhanced by comparison of a result to a reference database. The more high-quality data in the database, the more statistical power is afforded by the comparison. A serious weakness at present is the lack of reference materials in food matrices available to the community. Thus researchers have to rely on in-house standards for calibration and quality assurance. The result is that there are numerous datasets published that may be internally consistent but it is exceedingly difficult to combine these datasets into a cohesive database. This is particularly important for measurements of the hydrogen isotopes. Here we present a survey of the stable isotope (^2H, ^13C and ^15N) composition of 12 Reference Materials from the International Atomic Energy Agency catalogue. All but one of these materials are plant matter and have been developed as reference materials for other applications such as radionuclide or trace element measurements. Thus they have been verified as suitable materials in terms of stability and homogeneity for those tests. The purpose of this work is to ascertain if they are similarly suitable as stable isotope reference materials. The results from our survey show that there is a wide range in elemental and isotopic composition among these materials. For example, the ^15N values range from-13.5‰ to +18.6‰ and the nitrogen elemental composition range is from 0.7% to 9.7%. The ^13C values range from -20‰ to -40‰ and the carbon elemental composition ranges from 15% to 47%. We are now in the process of

  1. New Filler Material for Reference Free Part Encapsulation Fixture

    Institute of Scientific and Technical Information of China (English)

    LI Bei-zhi; YANG Jian-guo; ZHOU Hu

    2002-01-01

    Reference free part encapsulation (RFPE) is a nontraditional universal fixturing technique. In this paper,new filler material-a lower melting point alloy for RFPE technique is introduced. Based on experiment, the shrinlkage and expansion rate, the effect of filler on workpiece drift and the effect of filler thickness on cutting distortion are studied. The alloy has a good mechanical and physical performance and the need of RFPE fixturing can be perfectly satisfied. The result shows that if the formula and process parameters of filler material are properly selected, it can obviously improve the quality of the workpiece, enhance the machining efficiency and reduce the manufacturing cost.

  2. Certification of a uranium dioxide reference material for chemical analyses

    International Nuclear Information System (INIS)

    This report, issued by the Central Bureau for Nuclear Measurements (CBNM), describes the characterization of a uranium dioxide reference material with accurately determined uranium mass fraction for chemical analyses. The preparation, conditioning, homogeneity tests and the analyses performed on this material are described in Annex 1. The evaluation of the individual impurity results, total of impurities and uranium mass fraction are given in Annex 2. Information on a direct determination of uranium by titration is given in Annex 3. The uranium mass fraction (881.34+-0.13) g.kg-1 calculated in Annex 2 is given on the certificate

  3. Development of a Thin Film Magnetic Moment Reference Material.

    Science.gov (United States)

    Pappas, D P; Halloran, S T; Owings, R R; da Silva, F C S

    2008-01-01

    In this paper we present the development of a magnetic moment reference material for low moment magnetic samples. We first conducted an inter-laboratory comparison to determine the most useful sample dimensions and magnetic properties for common instruments such as vibrating sample magnetometers (VSM), SQUIDs, and alternating gradient field magnetometers. The samples were fabricated and then measured using a vibrating sample magnetometer. Their magnetic moments were calibrated by tracing back to the NIST YIG sphere, SRM 2853. PMID:27096108

  4. Characterization of the NIST seaweed Standard Reference Material

    DEFF Research Database (Denmark)

    Outola, I.; Filliben, J.; Inn, K.g.W.;

    2006-01-01

    method was found to be the most representative technique. The certified values were provided for 13 radionuclides and information values were given for 15 more radionuclides. Results for the natural decay series showed disequilibrium in both the uranium and thorium series. (c) 2006 Elsevier Ltd. All...

  5. Development and characterisation of a new line width reference material

    Science.gov (United States)

    Dai, Gaoliang; Zhu, Fan; Heidelmann, Markus; Fritz, Georg; Bayer, Thomas; Kalt, Samuel; Fluegge, Jens

    2015-11-01

    A new critical dimension (CD, often synonymously used for line width) reference material with improved vertical parallel sidewalls (IVPSs) has been developed and characterised. The sample has a size of 6 mm  ×  6 mm, consisting of 4 groups of 5  ×  5 feature patterns. Each feature pattern has a group of five reference line features with a nominal CD of 50 nm, 70 nm, 90 nm, 110 nm and 130 nm, respectively. Each feature pattern includes a pair of triangular alignment marks, applicable for precisely identifying the target measurement position, e.g. for comparison or calibration between different tools. The geometry of line features has been investigated thoroughly using a high-resolution transmission electron microscope and a CD atomic force microscope (CD-AFM). Their results indicate the high quality of the line features: the top corner radius of  strategy for the non-destructive calibration of the developed sample is introduced, which enables the application of the reference material in practice.

  6. Preparation and quality control of materials used in the reference buffer material

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, D.A.; Hnatiw, D.S.J.; Kohle, C.L.

    1992-09-15

    This document summarizes the methodologies developed for preparing the reference buffer material (RBM) for use in laboratory-scale and field-scale experiments. Two commercially available concrete mixers have been successfully used to repeatedly produce homogeneous bulk buffer and backfill materials. The components, blending procedures, quality control sampling requirements, and mixing checklists used in the production of the reference buffer material are presented. Use of these directions will ensure that consistent batching of sealing materials is achieved and operator-induced variability is minimized.

  7. Reference materials for nondestructive assay of special nuclear material. Volume 1. Uranium oxide plus graphite powder

    International Nuclear Information System (INIS)

    This manual describes the fabrication of reference materials for use in gamma-ray-based nondestructive assay of low-density uranium-bearing samples. The sample containers are 2-l bottles. The reference materials consist of small amounts of UO2 spread throughout a graphite matrix. The 235U content ranges from 0 to 100 g. The manual also describes the far-field assay procedure used with low-resolution detectors

  8. Characterization of Ricin and R. communis Agglutinin Reference Materials.

    Science.gov (United States)

    Worbs, Sylvia; Skiba, Martin; Söderström, Martin; Rapinoja, Marja-Leena; Zeleny, Reinhard; Russmann, Heiko; Schimmel, Heinz; Vanninen, Paula; Fredriksson, Sten-Åke; Dorner, Brigitte G

    2015-11-26

    Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential biological warfare agent. While different technologies for ricin analysis have been established, hardly any universally agreed-upon "gold standards" are available. Expert laboratories currently use differently purified in-house materials, making any comparison of accuracy and sensitivity of different methods nearly impossible. Technically challenging is the discrimination of ricin from R. communis agglutinin (RCA120), a less toxic but highly homologous protein also contained in R. communis. Here, we established both highly pure ricin and RCA120 reference materials which were extensively characterized by gel electrophoresis, liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI MS/MS), and matrix-assisted laser desorption ionization-time of flight approaches as well as immunological and functional techniques. Purity reached >97% for ricin and >99% for RCA120. Different isoforms of ricin and RCA120 were identified unambiguously and distinguished by LC-ESI MS/MS. In terms of function, a real-time cytotoxicity assay showed that ricin is approximately 300-fold more toxic than RCA120. The highly pure ricin and RCA120 reference materials were used to conduct an international proficiency test.

  9. Characterization of Ricin and R. communis Agglutinin Reference Materials

    Directory of Open Access Journals (Sweden)

    Sylvia Worbs

    2015-11-01

    Full Text Available Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential biological warfare agent. While different technologies for ricin analysis have been established, hardly any universally agreed-upon “gold standards” are available. Expert laboratories currently use differently purified in-house materials, making any comparison of accuracy and sensitivity of different methods nearly impossible. Technically challenging is the discrimination of ricin from R. communis agglutinin (RCA120, a less toxic but highly homologous protein also contained in R. communis. Here, we established both highly pure ricin and RCA120 reference materials which were extensively characterized by gel electrophoresis, liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI MS/MS, and matrix-assisted laser desorption ionization–time of flight approaches as well as immunological and functional techniques. Purity reached >97% for ricin and >99% for RCA120. Different isoforms of ricin and RCA120 were identified unambiguously and distinguished by LC-ESI MS/MS. In terms of function, a real-time cytotoxicity assay showed that ricin is approximately 300-fold more toxic than RCA120. The highly pure ricin and RCA120 reference materials were used to conduct an international proficiency test.

  10. Characterization of Ricin and R. communis Agglutinin Reference Materials.

    Science.gov (United States)

    Worbs, Sylvia; Skiba, Martin; Söderström, Martin; Rapinoja, Marja-Leena; Zeleny, Reinhard; Russmann, Heiko; Schimmel, Heinz; Vanninen, Paula; Fredriksson, Sten-Åke; Dorner, Brigitte G

    2015-12-01

    Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential biological warfare agent. While different technologies for ricin analysis have been established, hardly any universally agreed-upon "gold standards" are available. Expert laboratories currently use differently purified in-house materials, making any comparison of accuracy and sensitivity of different methods nearly impossible. Technically challenging is the discrimination of ricin from R. communis agglutinin (RCA120), a less toxic but highly homologous protein also contained in R. communis. Here, we established both highly pure ricin and RCA120 reference materials which were extensively characterized by gel electrophoresis, liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI MS/MS), and matrix-assisted laser desorption ionization-time of flight approaches as well as immunological and functional techniques. Purity reached >97% for ricin and >99% for RCA120. Different isoforms of ricin and RCA120 were identified unambiguously and distinguished by LC-ESI MS/MS. In terms of function, a real-time cytotoxicity assay showed that ricin is approximately 300-fold more toxic than RCA120. The highly pure ricin and RCA120 reference materials were used to conduct an international proficiency test. PMID:26703723

  11. Collaborative analysis for certification of zirconium and zirconium base alloy reference materials JAERI-Z11 to Z16

    International Nuclear Information System (INIS)

    The second Sub-Committee on Zircaloy Analysis was organized in April 1978, under the Committee on Analytical Chemistry on Nuclear Fuels and Reactor Materials, JAERI, for the renewal of zirconium and zirconium base alloy certified reference materials (CRMs). The Sub-Committee carried out collaborative analysis among 13 participating laboratories for the certification of the CRMs, JAERI-Z11 to Z18, after development, improvement and evaluation of analytical methods during the period of May 1978 to June 1982. As the result of the collaborative analysis, the certified value was given for 18 elements (Sn, Fe, Ni, Cr, B, Cd, U, Cu, Co, Mn, Pb, Al, Ti, Si, Mo, W, Hf, C) in the CRMs. The first part of this report includes general discussion, the second part principles of certification, the third part development and verification of analytical methods, and the fourth part evaluation of analytical results on 17 elements. Preparation of Z11 to Z18, and certification for carbon in JAERI-Z17 and Z18 were reported separately in JAERI-M 83-241 and M 83-035, respectively. (author)

  12. Multielement analysis of human hair reference material by instrumental neutron activation analysis

    International Nuclear Information System (INIS)

    A Human Hair (NIES No. 5) as an environmental reference material prepared by the National Institute for Environmental Studies of Japan (NIES) was analyzed by an instrumental neutron activation method. The human hair samples (ca. 200∼500 mg) were irradiated for 2 min or 5 h at Musashi Institute of Technology Research Reactor. The activated samples were measured by four gamma-ray spectrometories, namely a spectrometry using a coaxial Ge detector, anticoincidence and coincidence counting spectrometries using a coaxial Ge detector, and a well-type NaI (Tl) detector, and a low energy photon spectrometry (LEPS) using a planer Ge detector, to determine as many trace elements as possible with high sensitivity. Concentrations of 43 elements (Na, Mg, Al, Si, S, Cl, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br, Rb, Sr, Ag, Cd, Sn, Sb, I, Cs, Ba, La, Ce, Nd, Sm, Eu, Tb, Yb, Hf, Ta, Au, Hg, Th, U) were determined by these measurements. The analyzed values of many elements except Sr were in good agreement with NIES certified values determined by nine different analytical methods. (author)

  13. The preparation of uranium-doped glass reference materials for environmental measurements

    Science.gov (United States)

    Raptis, K.; Ingelbrecht, C.; Wellum, R.; Alonso, A.; De Bolle, W.; Perrin, R.

    2002-03-01

    Seven different uranium glass powders containing 5 mass% uranium with 235U abundances from natural to highly enriched have been prepared for the IRMM support programme to the International Atomic Energy Agency (IAEA) and for the IRMM external NUSIMEP quality control programme (Nuclear Signatures Interlaboratory Measurement Evaluation Programme). The particles will be primarily used, blended with (inactive) matrix glass powder in various ratios to simulate environmental samples containing "hot" particles in order to assess the performance of various separation and measurement techniques. High-purity borosilicate glass was prepared by blending of powders, melting and grinding by ball milling and jet milling to a powder of about 12 μm. A quantity of this glass was then blended with U 3O 8, melted and milled to powder. Laser diffraction measurements were made to ensure that the particle size distribution of the uranium glass matched that of the matrix glass in order to ensure homogeneous blending. The final yield was 30-40 g of each uranium glass and 1 kg of matrix glass. The glasses have been certified as reference materials for isotope abundances of uranium.

  14. Reference Material IAEA 434: Naturally Occurring Radionuclides in Phosphogypsum

    International Nuclear Information System (INIS)

    Phosphogypsum is generated as a by-product of the phosphoric acid based fertilizer industry. The discharge of phosphogypsum on earth surface deposits is a potential source of enhanced natural radiation and heavy metals, and the resulting environmental impact should be considered carefully to ensure safety and compliance with environmental regulations. In addition, phosphogypsum can be used to make several building materials and it is used in agriculture as a conditioner to maintain soil productivity in areas where soils are poor and erode easily. A reliable determination of naturally occurring radionuclides in phosphogypsum is necessary to comply with the radiation protection and environmental regulations. The IAEA-434 will assist laboratories in the IAEA Member States in validating their analytical methods for the determination of naturally occurring radionuclides in phosphogypsum and to control the quality of the produced analytical results. Reference values for the massic activities and associated standard uncertainties were established for: Pb-210, Ra-226, Th-230, U-234 and U-238. During sample production and certification, the requirements for reference material production and certification as stated in ISO guides 34 and 35 were taken into account. This report summarizes the preparation and certification process

  15. Electrodynamics in Arbitrary Reference Frames and in Arbitrary Material Media

    International Nuclear Information System (INIS)

    Full text: The investigation of electromagnetic phenomena in material media still belongs to the most difficult tasks of electrodynamics. Complexity and variability of material media practically exclude effective applications of methods and computational techniques elaborated in the framework of standard microscopic electrodynamics with classical vacuum as a ground state. In order to obtain satisfactorily exact descriptions of electromagnetic properties of complex material media one is enforced to use methods and approximations which are difficult to control. Moreover, they usually break covariance properties and the results obtained are valid in one reference frame which choice remains subjective and model dependent. Some time ago we have proposed a reformulation of Maxwell electrodynamics which opens new ways in study of electromagnetic processes in material media. The formalism gets rid of assumptions characteristic for vacuum electrodynamics only and it avoids the usage of constitutive relations as primary relations put on quantities needed for a complete description of an electromagnetic system. Fundamental properties of all electromagnetic quantities are their uniquely defined transformation rules and their analysis allows to determine the possible relations between them. Within such a scheme it is possible to introduce constitutive relations which do not have analogies in macroscopic classical electrodynamics. They may be used in description of microscopic electromagnetic processes in a different way than it is done in the framework of quantum electrodynamics. (author)

  16. Development and characterisation of a new line width reference material

    International Nuclear Information System (INIS)

    A new critical dimension (CD, often synonymously used for line width) reference material with improved vertical parallel sidewalls (IVPSs) has been developed and characterised. The sample has a size of 6 mm  ×  6 mm, consisting of 4 groups of 5  ×  5 feature patterns. Each feature pattern has a group of five reference line features with a nominal CD of 50 nm, 70 nm, 90 nm, 110 nm and 130 nm, respectively. Each feature pattern includes a pair of triangular alignment marks, applicable for precisely identifying the target measurement position, e.g. for comparison or calibration between different tools. The geometry of line features has been investigated thoroughly using a high-resolution transmission electron microscope and a CD atomic force microscope (CD-AFM). Their results indicate the high quality of the line features: the top corner radius of  <7 nm, vertical sidewall (slope mostly within 90°  ±  0.5°) and very small line width variation (LWR down to 0.36 nm). The application of the developed sample for calibrating the scaling factor and effective tip geometry of the CD-AFM are demonstrated. The scaling factor of the CD-AFM is calibrated to be 0.9988, coinciding well with the theoretical value 1 as the tool was calibrated to a traceable metrological atomic force microscope. The effective width of a CDR120-EBD tip is calibrated as 128.32 nm. Finally, a strategy for the non-destructive calibration of the developed sample is introduced, which enables the application of the reference material in practice. (paper)

  17. Characterization of national food agency shrimp and plaice reference materials for trace elements and arsenic species by atomic and mass spectrometric techniques

    DEFF Research Database (Denmark)

    Larsen, Erik Huusfeldt; Pedersen, Gitte Alsing; McLaren, J. W.

    1997-01-01

    The National Food Agency (NFA) of Denmark has produced and characterized NFA Plaice and NFA Shrimp reference materials (RMs) for the control of the accuracy of trace element and arsenic species determinations in similar seafood samples, The physical preparation of the materials included dissection...... mass spectrometry (MS/MS) for qualitative verification, Based on a rigorous statistical analysis of the analytical data using the DANREF software, it was decided to assign certified values for mercury, cadmium and arsenic in the NFA Shrimp, and mercury, selenium and arsenic in the NFA Plaice...

  18. Scalar material reference systems and loop quantum gravity

    Science.gov (United States)

    Giesel, K.; Thiemann, T.

    2015-07-01

    In the past, the possibility to employ (scalar) material reference systems in order to describe classical and quantum gravity directly in terms of gauge invariant (Dirac) observables has been emphasized frequently. This idea has been picked up more recently in loop quantum gravity with the aim to perform a reduced phase space quantization of the theory, thus possibly avoiding problems with the (Dirac) operator constraint quantization method for a constrained system. In this work, we review the models that have been studied on the classical and/or the quantum level and parametrize the space of theories considered so far. We then describe the quantum theory of a model that, to the best of our knowledge, has only been considered classically so far. This model could arguably be called the optimal one in this class of models considered as it displays the simplest possible true Hamiltonian, while at the same time reducing all constraints of general relativity.

  19. Production of Working Reference Materials for the Capability Evaluation Project

    Energy Technology Data Exchange (ETDEWEB)

    Phillip D. Noll, Jr.; Robert S. Marshall

    1999-03-01

    Nondestructive waste assay (NDA) methods are employed to determine the mass and activity of waste-entrained radionuclides as part of the National TRU (Trans-Uranic) Waste Characterization Program. In support of this program the Idaho National Engineering and Environmental Laboratory Mixed Waste Focus Area developed a plan to acquire capability/performance data on systems proposed for NDA purposes. The Capability Evaluation Project (CEP) was designed to evaluate the NDA systems of commercial contractors by subjecting all participants to identical tests involving 55 gallon drum surrogates containing known quantities and distributions of radioactive materials in the form of sealed-source standards, referred to as working reference materials (WRMs). Although numerous Pu WRMs already exist, the CEP WRM set allows for the evaluation of the capability and performance of systems with respect to waste types/configurations which contain increased amounts of {sup 241}Am relative to weapons grade Pu, waste that is dominantly {sup 241}Am, as well as wastes containing various proportions of depleted uranium. The CEP WRMs consist of a special mixture of PuO{sub 2}/AmO{sub 2} (IAP) and diatomaceous earth (DE) or depleted uranium (DU) oxide and DE and were fabricated at Los Alamos National Laboratory. The IAP WRMS are contained inside a pair of welded inner and outer stainless steel containers. The DU WRMs are singly contained within a stainless steel container equivalent to the outer container of the IAP standards. This report gives a general overview and discussion relating to the production and certification of the CEP WRMs.

  20. Polish reference material: soya bean flour (INCT-SBF-4) for inorganic trace analysis - preparation and certification

    International Nuclear Information System (INIS)

    Preparation, examination and certification of the new matrix reference material of biological origin: Soya Bean Flour (INCT-SBF-4) is described. The material was prepared from soya bean grown in India, not genetically modified. After milling, the material was sieved through the 150 mm nylon sieves and stored in a polyethylene (PE) bag. Approximately 50 kg of sieved soya bean flour was collected. Examination by optical microscopy revealed that Martin's diameter of over 90% of particles was below 50 mm. The whole lot of soya bean flour was then homogenized by mixing for 20 hours in a 110 dm3 PE drum rotated in three directions. Preliminary homogeneity testing by X-ray fluorescence (XRF) method and final checking of homogeneity by neutron activation analysis (NAA) after distribution of the material into containers revealed, that it is sufficiently homogeneous at least for a sample size ≥ 100 mg. In order to assure the long-term stability, all containers with INCT-SBF-4 were sterilized by electron beam radiation. Long-term stability was checked by analyzing concentrations of selected elements in the material stored in the air-conditioned room at 20 oC. Short-term stability was examined by the determination of concentrations of the selected elements in the bottle stored in the CO2 incubator at 37 oC. The material was certified on the basis of a worldwide interlaboratory comparison, in which 92 laboratories from 19 countries participated providing 1107 laboratory averages (4873 individual determinations) for 58 elements. A method of data evaluation leading to assignment of certified values was the same as that used previously in the Laboratory of the Department of Analytical Chemistry, Institute of Nuclear Chemistry and Technology. The results for a few elements were obtained by definitive methods developed in the Laboratory and used to support the certification process. Analytical uncertainties and stability uncertainties were quantified to arrive at combined

  1. Traceability and quality requirements for reference materials. The context for trace element speciation

    International Nuclear Information System (INIS)

    of methylmercury (IAEA-085 and IAEA- 086, Human Hair, IAEA-140/TM, Fucus and IAEA-142, Mussel Homogenate), RMs for trace element speciation represent a new type of RMs for the IAEA. RMs for trace element speciation belong to the group of matrix RMs. The simplest and possibly best definition of a matrix RM is that it is a 'natural' substance more representative of laboratory samples that has been chemically characterised for one or more elements, constituents, etc. with quantified uncertainty. 'Natural' materials are more complex, chemically, compositionally and structurally, than primary reference standards, which are often pure substances. On the other hand, the chemical characterisation of 'natural' materials usually has a greater level of uncertainty and is less straightforward in terms of traceability. It is also true to say that the majority of matrix RMs, available, including the RMs produced by the IAEA, have been certified through laboratory intercomparison or measurement programmes

  2. Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test.

    Science.gov (United States)

    Weisemann, Jasmin; Krez, Nadja; Fiebig, Uwe; Worbs, Sylvia; Skiba, Martin; Endermann, Tanja; Dorner, Martin B; Bergström, Tomas; Muñoz, Amalia; Zegers, Ingrid; Müller, Christian; Jenkinson, Stephen P; Avondet, Marc-Andre; Delbrassinne, Laurence; Denayer, Sarah; Zeleny, Reinhard; Schimmel, Heinz; Åstot, Crister; Dorner, Brigitte G; Rummel, Andreas

    2015-12-01

    The detection and identification of botulinum neurotoxins (BoNT) is complex due to the existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert laboratories currently use different technical approaches to detect, identify and quantify BoNT, but due to the lack of (certified) reference materials, analytical results can hardly be compared. In this study, the six BoNT/A1-F1 prototypes were successfully produced by recombinant techniques, facilitating handling, as well as improving purity, yield, reproducibility and biosafety. All six BoNTs were quantitatively nicked into active di-chain toxins linked by a disulfide bridge. The materials were thoroughly characterized with respect to purity, identity, protein concentration, catalytic and biological activities. For BoNT/A₁, B₁ and E₁, serotypes pathogenic to humans, the catalytic activity and the precise protein concentration were determined by Endopep-mass spectrometry and validated amino acid analysis, respectively. In addition, BoNT/A₁, B₁, E₁ and F₁ were successfully detected by immunological assays, unambiguously identified by mass spectrometric-based methods, and their specific activities were assigned by the mouse LD50 bioassay. The potencies of all six BoNT/A1-F1 were quantified by the ex vivo mouse phrenic nerve hemidiaphragm assay, allowing a direct comparison. In conclusion, highly pure recombinant BoNT reference materials were produced, thoroughly characterized and employed as spiking material in a worldwide BoNT proficiency test organized by the EQuATox consortium. PMID:26703728

  3. Development of two fine particulate matter standard reference materials (<4 μm and <10 μm) for the determination of organic and inorganic constituents.

    Science.gov (United States)

    Schantz, Michele M; Cleveland, Danielle; Heckert, N Alan; Kucklick, John R; Leigh, Stefan D; Long, Stephen E; Lynch, Jennifer M; Murphy, Karen E; Olfaz, Rabia; Pintar, Adam L; Porter, Barbara J; Rabb, Savelas A; Vander Pol, Stacy S; Wise, Stephen A; Zeisler, Rolf

    2016-06-01

    Two new Standard Reference Materials (SRMs), SRM 2786 Fine Particulate Matter (Particulate Matter (particulate matter (PM). These materials have been characterized for the mass fractions of selected polycyclic aromatic hydrocarbons (PAHs), nitrated PAHs, brominated diphenyl ether (BDE) congeners, hexabromocyclododecane (HBCD) isomers, sugars, polychlorinated dibenzo-p-dioxin (PCDD) and dibenzofuran (PCDF) congeners, and inorganic constituents, as well as particle-size characteristics. These materials are the first Certified Reference Materials available to support measurements of both organic and inorganic constituents in fine PM. In addition, values for PAHs are available for RM 8785 Air Particulate Matter on Filter Media. As such, these SRMs will be useful as quality control samples for ensuring compatibility of results among PM monitoring studies and will fill a void to assess the accuracy of analytical methods used in these studies. Graphical Abstract Removal of PM from filter for the preparation of SRM 2786 Fine Particulate Matter.

  4. Quantitative micro x-ray fluorescence analyses without reference standard material; Referenzprobenfreie quantitative Mikro-Roentgenfluoreszenzanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, Timo

    2009-07-15

    X-ray fluorescence analysis (XRF) is a standard method for non-destructive investigations. Due to the development of polycapillary optics and SDDdetectors requiring no cooling with liquid nitrogen, XRF becomes a suitable method for a large number of applications, e. g. for the analysis of objects in arts and archaeology. Spectrometers developed for those purposes allow investigations outside of laboratories und provide excitation areas with diameters of 10-70 {mu}m. In most applications, quantification of XRF data is realized by the usage of standard reference materials. Due to absorption processes in the samples the accuracy of the results depends strongly on the similarity of the sample and the reference standard. In cases where no suitable references are available, quantification can be done based on the ''fundamental parameter (fp) method''. This quantification procedure is based on a set of equations describing the fluorescence production and detection mathematical. The cross sections for the interaction of x-rays with matter can be taken from different databases. During an iteration process the element concentrations can be determined. Quantitative XRF based on fundamental parameters requires an accurate knowledge of the excitation spectrum. In case of a conventional setup this spectrum is given by the X-ray tube spectrum and can be calculated. The use of polycapillary optics in micro-XRF spectrometers changes the spectral distribution of the excitation radiation. For this reason it is necessary to access the transmission function of the used optic. The aim of this work is to find a procedure to describe this function for routine quantification based on fundamental parameters. Most of the measurements have been carried out using a commercial spectrometer developed for applications in arts and archaeology. On the one hand the parameters of the lens, used in the spectrometer, have been investigated by different experimental characterization

  5. Preparation, characterization and certification of uranium isotope reference materials; Preparacao, Caracterizacao e certificacao de materiais de referencia isotopicos de uranio

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira Junior, Olivio Pereira de

    2006-07-01

    This work describes the preparation, characterization and certification of a set of uranium isotope reference materials ranging from 0.5 to 20.0 % of {sup 235}U in mass. The most important concepts of metrology in chemical measurements were applied so that the certified quantities in these materials could be directly traceable to the International System of Units (SI). As a consequence of this approach, these materials can be used in the instruments calibration, estimation of measurement uncertainty, method validation, assessment of performance of analysts, quality control routines and interlaboratory comparison programmes. The most advanced methods and techniques in mass spectrometry, that is, gas source mass spectrometry (GSMS), thermal ionisation mass spectrometry (TIMS) and inductively coupled plasma mass spectrometry (ICPMS) were investigated to identify which are the dominant components in the uncertainty and to quantify its contribution to the final value of the measurement uncertainty of the isotopic ratio. The results obtained were then compared to verify which are the methods and techniques associated to the lowest measurement uncertainty values. The isotope amount ratio n({sup 235}U)/n({sup 238}U) was certified in the materials produced to expanded uncertainties ranging from 0.02 to 0.10 % and the ratios n({sup 234}U)/n({sup 238}U) and n({sup 236}U)/n({sup 238}U), to uncertainties ranging from 0.03 to 2.20 %. These values fully comply to the requirements of the isotopic characterization of nuclear fuel as well as the analysis of environmental samples for nuclear safeguards. (author)

  6. Certified Schools - SEVIS

    Data.gov (United States)

    Department of Homeland Security — Certified schools must provide specific information regarding the school, the nature and requirements of the educational program, location and contact information,...

  7. Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds.

    Science.gov (United States)

    Schantz, Michele M; Benner, Bruce A; Heckert, N Alan; Sander, Lane C; Sharpless, Katherine E; Vander Pol, Stacy S; Vasquez, Y; Villegas, M; Wise, Stephen A; Alwis, K Udeni; Blount, Benjamin C; Calafat, Antonia M; Li, Zheng; Silva, Manori J; Ye, Xiaoyun; Gaudreau, Éric; Patterson, Donald G; Sjödin, Andreas

    2015-04-01

    Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers' Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers' Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants.

  8. LA-ICP-MS of magnetite: Methods and reference materials

    Science.gov (United States)

    Nadoll, P.; Koenig, A.E.

    2011-01-01

    Magnetite (Fe3O4) is a common accessory mineral in many geologic settings. Its variable geochemistry makes it a powerful petrogenetic indicator. Electron microprobe (EMPA) analyses are commonly used to examine major and minor element contents in magnetite. Laser ablation ICP-MS (LA-ICP-MS) is applicable to trace element analyses of magnetite but has not been widely employed to examine compositional variations. We tested the applicability of the NIST SRM 610, the USGS GSE-1G, and the NIST SRM 2782 reference materials (RMs) as external standards and developed a reliable method for LA-ICP-MS analysis of magnetite. LA-ICP-MS analyses were carried out on well characterized magnetite samples with a 193 nm, Excimer, ArF LA system. Although matrix-matched RMs are sometimes important for calibration and normalization of LA-ICP-MS data, we demonstrate that glass RMs can produce accurate results for LA-ICP-MS analyses of magnetite. Cross-comparison between the NIST SRM 610 and USGS GSE-1G indicates good agreement for magnetite minor and trace element data calibrated with either of these RMs. Many elements show a sufficiently good match between the LA-ICP-MS and the EMPA data; for example, Ti and V show a close to linear relationship with correlation coefficients, R2 of 0.79 and 0.85 respectively. ?? 2011 The Royal Society of Chemistry.

  9. Metallurgical and chemical characterization of copper alloy reference materials within laser ablation inductively coupled plasma mass spectrometry: Method development for minimally-invasive analysis of ancient bronze objects

    Energy Technology Data Exchange (ETDEWEB)

    Walaszek, Damian, E-mail: damian.walaszek@empa.ch [Laboratory for Analytical Chemistry, Swiss Federal Laboratories for Materials Science and Technology, Überlandstrasse 129, CH-8600 Dübendorf (Switzerland); University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw (Poland); Senn, Marianne [Laboratory for Analytical Chemistry, Swiss Federal Laboratories for Materials Science and Technology, Überlandstrasse 129, CH-8600 Dübendorf (Switzerland); Faller, Markus [Laboratory for Jointing Technology and Corrosion, Swiss Federal Laboratories for Materials Science and Technology, Überlandstrasse 129, CH-8600 Dübendorf (Switzerland); Philippe, Laetitia [Laboratory for Mechanics of Materials and Nanostructures, Swiss Federal Laboratories for Materials Science and Technology, Feuerwerkstrasse 39, CH-3602 Thun (Switzerland); Wagner, Barbara; Bulska, Ewa [University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw (Poland); Ulrich, Andrea [Laboratory for Analytical Chemistry, Swiss Federal Laboratories for Materials Science and Technology, Überlandstrasse 129, CH-8600 Dübendorf (Switzerland)

    2013-01-01

    The chemical composition of ancient metal objects provides important information for manufacturing studies and authenticity verification of ancient copper or bronze artifacts. Non- or minimal-destructive analytical methods are preferred to mitigate visible damage. Laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) enables the determination of major elements as well as impurities down to lower ppm-levels, however, accuracy and precision of analysis strongly depend on the homogeneity of reference materials used for calibration. Moreover, appropriate analytical procedures are required e.g. in terms of ablation strategies (scan mode, spot size, etc.). This study reviews available copper alloy (certified) reference materials — (C)RMs from different sources and contributes new metallurgical data on homogeneity and spatial elemental distribution. Investigations of the standards were performed by optical and scanning electron microscopy with X-ray spectrometry (SEM-EDX) for the following copper alloy and bronze (certified) reference materials: NIST 454, BAM 374, BAM 211, BAM 227, BAM 374, BAM 378, BAS 50.01-2, BAS 50.03-4, and BAS 50.04-4. Additionally, the influence of inhomogeneities on different ablation and calibration strategies is evaluated to define an optimum analytical strategy in terms of line scan versus single spot ablation, variation of spot size, selection of the most appropriate RMs or minimum number of calibration reference materials. - Highlights: ► New metallographic data for copper alloy reference materials are provided. ► Influence of RMs homogeneity on quality of LA-ICPMS analysis was evaluated. ► Ablation and calibration strategies were critically discussed. ► An LA-ICPMS method is proposed for analyzing most typical ancient copper alloys.

  10. Reference Materials in LIS Instruction: A Delphi Study

    Science.gov (United States)

    Rabina, Debbie

    2013-01-01

    This paper presents the results of a Delphi study conducted over a two-month period in 2011. The purpose of the study was to identify reference sources that should be covered in basic reference courses taught in LIS programs in the United States. The Delphi method was selected for its appropriateness in soliciting expert opinions and assessing the…

  11. 40 CFR 600.011-93 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at the U.S. Environmental Protection.... Document number and name 40 CFR part 600 reference ASTM E 29-67 (Reapproved 1973) Standard Recommended... the U.S. and Canada), or at http://www.sae.org. Document No. and name 40 CFR part 600 reference...

  12. Certified Subterm Criterion and Certified Usable Rules

    OpenAIRE

    Sternagel, Christian; Thiemann, René

    2010-01-01

    In this paper we present our formalization of two important termination techniques for term rewrite systems: the subterm criterion and the reduction pair processor in combination with usable rules. For both techniques we developed executable check functions in the theorem prover Isabelle/HOL which can certify the correct application of these techniques in some given termination proof. As there are several variants of usable rules we designed our check function in such a way ...

  13. ENERGY STAR Certified Boilers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Boilers that are effective as of October 1,...

  14. FDA Certified Mammography Facilities

    Science.gov (United States)

    ... Products Radiation-Emitting Products Home Radiation-Emitting Products Mammography Quality Standards Act and Program Consumer Information (MQSA) ... it Email Print This list of FDA Certified Mammography Facilities is updated weekly. If you click on ...

  15. ENERGY STAR Certified Furnaces

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 4.0 ENERGY STAR Program Requirements for Furnaces that are effective as of February 1,...

  16. ENERGY STAR Certified Computers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 6.1 ENERGY STAR Program Requirements for Computers that are effective as of June 2,...

  17. Blood plasma reference material: a global resource for proteomic research.

    Science.gov (United States)

    Malm, Johan; Danmyr, Pia; Nilsson, Rolf; Appelqvist, Roger; Végvári, Akos; Marko-Varga, György

    2013-07-01

    There is an ever-increasing awareness and interest within the clinical research field, creating a large demand for blood fraction samples as well as other clinical samples. The translational research area is another field that is demanding for blood samples, used widely in proteomics, genomics, as well as metabolomics. Blood samples are globally the most common biological samples that are used in a broad variety of applications in life science. We hereby introduce a new reference blood plasma standard (heparin) that is aimed as a global resource for the proteomics community. We have developed these reference plasma standards by defining the Control group as those with C-reactive protein levels 30 mg/L. In these references we have used both newborn children 1-2 weeks, as well as youngsters 15-30 years, and middle aged 30-50 years, and elderly patients at the ages of 65+. In total, there were 80 patients in each group in the reference plasma pools. We provide data on the developments and characteristics of the reference blood plasma standards, as well as what is used by the team members at the respective laboratories. The standards have been evaluated by pilot sample processing in biobanking operations and are currently a resource that allows the Proteomic society to perform quantitative proteomic studies. By the use of high quality reference plasma samples, global initiatives, such as the Chromosome Human Proteome Project (C-HPP), will benefit as one scientific program when the entire human proteome is mapped and linked to human diseases. The plasma reference standards are a global resource and can be accessed upon request. PMID:23701512

  18. Acquisition of improved reference values for cesium, iodine, strontium, thorium, and uranium in selected NIST reference materials.

    Science.gov (United States)

    Parr, R M; Kawamura, H; Iyengar, G V

    1999-01-01

    As part of a study on the ingestion and organ content of some trace elements of importance in radiological protection, additional work has been undertaken to acquire improved reference values for cesium, iodine, strontium, thorium, and uranium in four selected reference materials provided by the US National Institute of Standards and Technology. The materials are SRM-1548 Total Diet, SRM-1548a Typical Diet, SRM-1486 Bone Meal, and RM-8414 Bovine Muscle. A coordinated study was undertaken with the help of seven selected laboratories in five countries. Instrumental and radiochemical neutron activation analysis and inductively coupled plasma-mass spectrometry were the analytical main techniques used. PMID:10676473

  19. 10 CFR 431.443 - Materials incorporated by reference.

    Science.gov (United States)

    2010-01-01

    ... this section for incorporation by reference in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Any... Test Methods for Single- and Three-Phase Small Motors, IBR approved for § 431.444. (2) (c) IEEE...-1331, 1-800-678-IEEE (4333), or go to http://www.ieee.org/web/publications/home/index.html. (1)...

  20. 9 CFR 77.1 - Material incorporated by reference.

    Science.gov (United States)

    2010-01-01

    ... been approved for incorporation by reference into the Code of Federal Regulations by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. (a) The procedures... 1141, USDA South Building, 14th Street and Independence Avenue, SW., Washington, DC; or (3) May...

  1. A new series of uranium isotope reference materials for investigating the linearity of secondary electron multipliers in isotope mass spectrometry

    Science.gov (United States)

    Richter, S.; Alonso, A.; Aregbe, Y.; Eykens, R.; Kehoe, F.; Kühn, He; Kivel, N.; Verbruggen, A.; Wellum, R.; Taylor, P. D. P.

    2009-04-01

    A new series of gravimetrically prepared uranium isotope reference materials, the so-called IRMM-074 series, with the n(235U)/n(238U) isotope ratio held constant at unity and the n(233U)/n(238U) isotope ratios varying from 1.0 to 10-6 has been prepared and certified. This series is suited for calibration of secondary electron multipliers used widely in isotope mass spectrometry, in particular for techniques such as thermal ionization mass spectrometry (TIMS), inductively coupled plasma mass spectrometry (ICPMS), accelerator mass spectrometry (AMS) and resonance ionization mass spectrometry (RIMS). The new IRMM-074 was prepared as a replacement for the already exhausted IRMM-072 predecessor series. Uranium materials with high isotopic enrichments of 233U, 235U and 238U were purified using identical methods involving separation on anion and cation column followed by a precipitation as peroxide. The oxides were calcined to convert them to U3O8 simultaneously, in an oven installed in a glove-box that provided a controlled low-humidity environment. The oxides of 235U and 238U were weighed and mixed with a mole ratio n(235U)/n(238U) = 1.0 and then dissolved. The 233U oxide was dissolved to form a separate solution with the same concentration and 6rom this primary solution three dilutions were made by weighing. A weighed amount of the n(235U)/n(238U) solution and weighed amounts of the 233U solutions were mixed in various proportions in order to achieve n(233U)/n(238U) isotope ratios varying from 1.0 to 10-6. The methods for the preparation, the mixing and the mixing calculations are described. The expanded uncertainties (coverage factor k = 2) of the certified isotope ratios for the IRMM-074 series are 0.015% for the n(235U)/n(238U) ratio and 0.025% for the n(233U)/n(238U) ratios, which constitutes an improvement compared to those of the predecessor IRMM-072 series. In addition, recent observations regarding the linearity response of secondary electron multipliers (SEMs

  2. Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test

    Directory of Open Access Journals (Sweden)

    Jasmin Weisemann

    2015-11-01

    Full Text Available The detection and identification of botulinum neurotoxins (BoNT is complex due to the existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert laboratories currently use different technical approaches to detect, identify and quantify BoNT, but due to the lack of (certified reference materials, analytical results can hardly be compared. In this study, the six BoNT/A1–F1 prototypes were successfully produced by recombinant techniques, facilitating handling, as well as improving purity, yield, reproducibility and biosafety. All six BoNTs were quantitatively nicked into active di-chain toxins linked by a disulfide bridge. The materials were thoroughly characterized with respect to purity, identity, protein concentration, catalytic and biological activities. For BoNT/A1, B1 and E1, serotypes pathogenic to humans, the catalytic activity and the precise protein concentration were determined by Endopep-mass spectrometry and validated amino acid analysis, respectively. In addition, BoNT/A1, B1, E1 and F1 were successfully detected by immunological assays, unambiguously identified by mass spectrometric-based methods, and their specific activities were assigned by the mouse LD50 bioassay. The potencies of all six BoNT/A1–F1 were quantified by the ex vivo mouse phrenic nerve hemidiaphragm assay, allowing a direct comparison. In conclusion, highly pure recombinant BoNT reference materials were produced, thoroughly characterized and employed as spiking material in a worldwide BoNT proficiency test organized by the EQuATox consortium.

  3. USGS Reference Materials Program: Serving the Needs of the Global Analytical Community

    Science.gov (United States)

    Wolf, Ruth E.; Wilson, Stephen A.

    2007-01-01

    Every year in the United States, millions of measurements are made on the chemical composition of items that affect us on a daily basis. The accuracy of these measurements is routinely determined by the analysis of appropriate reference materials. In the field of earth science, reference materials are particularly important because they help us develop a better understanding of the processes that have shaped, and continue to shape the world around us. USGS reference materials are distributed internationally to organizations involved in geochemical and environmental analysis, instrumentation and methods development, and industrial research and quality assurance. Reference materials are widely used in the development and validation of geochemical models used by the USGS.

  4. Household Hazardous Materials and Their Labels: A Reference for Teachers.

    Science.gov (United States)

    Dean, Lillian F.

    Household hazardous materials are products or wastes which are toxic, corrosive, reactive, and/or ignitable. Although common products such as pesticides, oils, gasoline, solvents, cleaners, and polishes are hazardous, students and adults are not always aware of potential dangers. This sourcebook contains definitions and examples of household…

  5. 10 CFR 431.95 - Materials incorporated by reference.

    Science.gov (United States)

    2010-01-01

    ... INDUSTRIAL EQUIPMENT Commercial Air Conditioners and Heat Pumps Test Procedures § 431.95 Materials... published in 1998, “Water-source heat pumps—Testing and rating for performance—Part 1: Water-to-air and...) published in 2004, “Standard for Packaged Terminal Air-Conditioners and Heat Pumps,” IBR approved for §...

  6. The preparation of biological reference materials for QUASIMEME

    NARCIS (Netherlands)

    Kotterman, M.J.J.

    2011-01-01

    Biological materials, consisting of three different batches of mussels; from Den Helder harbour (POPs, TBT), Irish mussels (metals) and Wadden Sea mussels, fortified with highly contaminated mussels from Belgium (POPs), and of one batch of turbot liver (metals) have been prepared for use in QUASIMEM

  7. Alternative buffer material. Status of the ongoing laboratory investigation of reference materials and test package 1

    Energy Technology Data Exchange (ETDEWEB)

    Svensson, Daniel [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Dueck, Ann; Nilsson, Ulf; Olsson, Siv; Sanden, Torbjoern [Clay Technology AB, Lund (Sweden); Lydmark, Sara; Jaegerwall, Sara; Pedersen, Karsten [Microbial Analytics Sweden AB, Moelnlycke (Sweden); Hansen, Staffan [LTH Lund Univ., Lund (Sweden)

    2011-07-15

    Bentonite clay is part of the Swedish KBS-3 design of final repositories for high level radioactive waste. Wyoming bentonite with the commercial name MX-80 (American Colloid Co) has long been the reference for buffer material in the KBS-3 concept. Extending the knowledge base of alternative buffer materials will make it possible to optimize regarding safety, availability and cost. For this reason the field experiment Alternative Buffer Material (ABM) was started at Aespoe Hard Rock Laboratory during 2006. The experiment includes three medium-scale test packages, each consisting of a central steel tube with heaters, and a buffer of compacted clay. Eleven different clays were chosen for the buffers to examine effects of smectite content, interlayer cations and overall iron content. Also bentonite pellets with and without additional quartz are being tested. The buffer in package 1 had been subjected to wetting by formation water and heating for more than two years (at 130 deg C for {approx} 1 year) when it was retrieved and analyzed. The main purposes of the project were to characterise the clays with respect to hydro-mechanical properties, mineralogy and chemical composition and to identify any differences in behaviour or long term stability. The diversity of clays and the heater of steel also make the experiment suitable for studies of iron-bentonite interactions. This report concerns the work accomplished up to now and is not to be treated as any final report of the project.

  8. 16O thin film reference materials for nuclear reaction analysis

    International Nuclear Information System (INIS)

    Full text: Thin film Ta2O5 samples were distributed to CRP participants for use in the round-robin exercise. This appendix describes how these samples were prepared and characterized. Preparation was made using anodic oxidation of tantalum using an electrolyte solution of 4% ammonium citrate prepared with water of natural 16O isotopic composition. A constant anodising current of 4 mA/cm2 was maintained until the desired electrolysis v voltage was reached, then stopped immediately. The areal density of 16O in these thin Ta2O5 films was determined by NRA using the method described elsewhere and comparing the data with that from a primary anodic Ta2O5 standard kindly made available to us by Dr C. Ortega of GPS, Paris. The 16O(d,p1)14N reaction at 850 keV was used with the protons detected with a 300 mm2 silicon detector located at an angle of 150 deg. A 12 μm MylarTM foil covered the detector. Detector count rates were kept sufficiently low so that deadtime corrections are negligible. There are various sources of uncertainty which when compounded, produce the final uncertainty in the 16O areal density of the thin film samples. The major sources of uncertainty are: 1. The primary reference standard is estimated to have an absolute value that is within ± 3% of the true value. 2. There is a small low energy tail on the p1 peak in the NRA spectrum, most likely due to oxygen dissolved in the bulk tantalum. The counts in this tailing are less than 2% of the gross counts recorded in the spectrum peak, and similar in magnitude from sample to sample. We assign a systematic error of 0.5% to the background correction for all samples. There is negligible change in the total sample uncertainty when this systematic error is added in quadrature to the uncertainty of the primary reference standard. 3. The reproducibility of peak areas from several measurements was better than 1%. This indicates that sample homogeneity and current integration were both sufficiently good that their

  9. Alpha damage in non-reference waste form matrix materials

    International Nuclear Information System (INIS)

    Although bitumen is the matrix material currently used for European α-bearing intermediate level waste streams, polymer and polymer-modified cement matrices could have advantages over bitumen for such wastes. Two organic matrix systems have been studied - an epoxide resin, and an epoxide modified cement. Alpha irradiations were carried out by incorporating 241Am at approx. 0.9 Ci/l. Comparisons have been made with unirradiated material and with materials which had been γ-irradiated to the same dose as the α-irradiated samples. Measurements were made of dimensional changes, mechanical properties and the leaching behaviour of 241Am and 137Cs. A limited amount of swelling (< 3%) was observed in α-irradiated epoxide resin; none was observed in the epoxide modified cement. Gamma irradiation to 300 kGy has no significant effect on the mechanical properties of either system. However, alpha irradiation to the same dose produced significant changes in flexural strength, an increase for the polymer and a decrease for the polymer-cement. Leaching in these systems was found to be a diffusion-controlled process; alpha irradiation to approx. 250 kGy has little effect on the leaching behaviour of either system. (author)

  10. Standard reference materials: srm 768: temperature reference standard for use below 0. 5 k

    Energy Technology Data Exchange (ETDEWEB)

    Stolen, R.J. Jr; Dove, R.B.

    1979-04-01

    Cryogenic temperature scales are now available (viz., the newly created EPT-76) which are quite accurate and which extend deep into the cryogenic region (as low as 0.5 K). It is the region below 0.5 K where no formal scale exists which is of concern here. By developing a compact device which provides five reference temperatures from 0.015 K to 0.21 K, the authors hope to provide a lingua franca by which experimental results of different laboratories involving the parameter temperature may be meaningfully compared. Such a device, designated SRM 768, is now available and consists of a self-contained assembly of coils and five samples which can be used to provide in situ temperature calibration. Simple room temperature electronics readily permit the observation of the five narrow and highly reproducible superconducting phase transitions. These phase transitions have been assigned temperature values by means of fundamental thermometers used at the National Bureau of Standards. Provided that care is exercised in reducing the magnetic field acting upon the device, the user can confidently expect to achieve a temperature reproducibility and traceability to the NBS temperature scale of plus or minus 0.3 mK.

  11. 238U/235U determinations of some commonly used reference materials and U-bearing accessory minerals (Invited)

    Science.gov (United States)

    Condon, D.; Noble, S.; McLean, N.; Bowring, S. A.

    2009-12-01

    We have determined 238U/235U ratios for a suite of commonly used natural (CRM 112a, SRM 950a, HU-1) and synthetic (IRMM 184 and CRM U500) uranium reference materials in addition to several U-bearing accessory phases (zircon and monazite) by thermal ionisation mass-spectrometry (TIMS) using the IRMM 3636 233U-236U double spike to accurately correct for mass fractionation. The 238U/235U values for the natural uranium reference materials differ, by up to 0.1%, from the widely used ‘consensus’ value (137.88) with all having 238U/235U values less than 137.88. Similarly, initial 238U/235U data from zircon and monazite yield 238U/235U values that are lower than the ‘consensus’ value. The data obtained from U-bearing minerals is used to assess how the uncertainty in the 238U/235U ratio contributes to the systematic discordance observed in 238U/206Pb and 235U/207Pb dates (Mattinson, 2000; Schoene et al., 2006) which has traditionally been wholly attributed to error in the U decay constants. The 238U/235U determinations made on the synthetic reference materials yield results that are considerably more precise and accurate than the certified values (0.02% vs. 0.1% for CRM U500). The calibration of isotopic tracers used for U-daughter geochronology that are partially based upon these reference materials, and the resultant age determinations, will benefit from increased accuracy and precision. Mattinson, J.M., 2000. Revising the “gold standard”—the uranium decay constants of Jaffey et al., 1971. Eos Trans. AGU, Spring Meet. Suppl., Abstract V61A-02. Schoene B., Crowley J.L., Condon D.C., Schmitz M.D., Bowring S.A., 2006, Reassessing the uranium decay constants for geochronology using ID-TIMS U-Pb data. Geochimica et Cosmochimica Acta 70: 426-445

  12. [Latin American regional reference materials for porcine heparin and bovine heparin].

    Science.gov (United States)

    Albertengo, M E; Cinto, R O; Araldi, H T; Vernengo, M J

    1990-02-01

    In agreement with the Regional Programme of Reference Materials of the Panamerican Health Organization the Instituto Nacional de Farmacología y Bromatología of Buenos Aires designed a study for the calibration of a Reference Material for Heparin, porcine, mucosal and a Reference Material for Heparin, bovine, mucosal. The assay methods used in this study were those described in the United States Pharmacopeia XXI Ed and British Pharmacopoeia 1980, Addendum 1983. The overall combined potency estimates of both heparin in preparations relative to 4th Int.St. was 1633.83 UI/ampoule (95% confidence limits 1609.70-1657.96 UI/ampoule) for porcine heparin and 1332.31 UI/ampoule (95% confidence limits, 1302.31-1361.77 UI/ampoule) for bovine heparin. The assigned unitage was 1630 UI/ampoule for the porcine Reference Material and 1330 UI/ampoule for the bovine Reference Material.

  13. Development of reference materials for SNF NDA systems

    Energy Technology Data Exchange (ETDEWEB)

    Klann, R. T.

    2000-02-29

    The Department of Energy has over 200 different fuel types which will be placed in a geologic repository for ultimate disposal. At the present time, DOE EM is responsible for assuring safe existing conditions, achieving interim storage, and preparing for final disposition. Each task is governed by regulations which dictate a certain degree of knowledge regarding the contents and condition of the fuel. This knowledge and other associated characteristics are referred to as data needs. It is the stance of DOE EM, that personnel and economic resources are not available to obtain the necessary data to characterize such individual fuel type for final disposal documentation purposes. In addition, it is beyond the need of DOE to do so. This report describes the effort to classify the 200+ fuel types into a subset of fuel types for the purpose of non-destructive analysis (NDA) measurement system development and demonstration testing in support of the DOE National Spent Nuclear Fuel (NSNFP) Program. The fuel types have been grouped into 37 groups based on fuel composition, fuel form, assembly size, enrichment, and other characteristics which affect NDA measurements (e.g., neutron poisons).

  14. Evolutionary design of bone scaffolds with reference to material selection.

    Science.gov (United States)

    Heljak, M K; Swięszkowski, W; Lam, C X F; Hutmacher, D W; Kurzydłowski, K J

    2012-01-01

    The favourable scaffold for bone tissue engineering should have desired characteristic features, such as adequate mechanical strength and three-dimensional open porosity, which guarantee a suitable environment for tissue regeneration. In fact, the design of such complex structures like bone scaffolds is a challenge for investigators. One of the aims is to achieve the best possible mechanical strength-degradation rate ratio. In this paper we attempt to use numerical modelling to evaluate material properties for designing bone tissue engineering scaffold fabricated via the fused deposition modelling technique. For our studies the standard genetic algorithm was used, which is an efficient method of discrete optimization. For the fused deposition modelling scaffold, each individual strut is scrutinized for its role in the architecture and structural support it provides for the scaffold, and its contribution to the overall scaffold was studied. The goal of the study was to create a numerical tool that could help to acquire the desired behaviour of tissue engineered scaffolds and our results showed that this could be achieved efficiently by using different materials for individual struts. To represent a great number of ways in which scaffold mechanical function loss could proceed, the exemplary set of different desirable scaffold stiffness loss function was chosen.

  15. Critical Evaluation of an Intercalibration Project Focused on the Definition of New Multi-Element Soil Reference Materials (AMS-MO1 and AMS-ML1

    Directory of Open Access Journals (Sweden)

    Livia Vittori Antisari

    2014-12-01

    Full Text Available Soils are complex matrices and their geochemical investigation necessarily needs reliable Certified Reference Materials (CRMs, i.e. standards, to support analytical precision and accuracy. In particular, the definition of soil multi-element CRMs is particularly complex and involves an inter-laboratory program that employs numerous analytical techniques. In this study, we present the results of the inter-calibration experiment focused on the certification of two new soil standards named AMS-ML1 and AMS-MO1. The two soils developed on sandstone and serpentinite parent materials, respectively. The experiment involved numerous laboratories and focused on the evaluation of soil physicochemical parameters and geochemical analyses of major and trace elements by X-ray fluorescence (XRF and Inductive Coupled Plasma techniques (ICP-OES and ICP-MS. The data was statistically elaborated. Three levels of repeatability and accuracy in function of the different analytical methods and instrumentation equipment was observed. The statistical evaluation of the results obtained by ICP-OES on Aqua Regia extracts (i.e., Lilliefors test for normally, Grubbs test for outliers, Cochran test for outliers in variances and ANOVA allowed to computed some certified values for the two proposed soil standards. This preliminary study will represent the first step of a more thorough intercalibration ring-test involving a higher number of laboratories, in order to propose the investigated matrices as CRMs.

  16. Reference material IAEA 413: Major, minor and trace elements in algae

    International Nuclear Information System (INIS)

    Reference materials are a basic requirement for any sort of quantitative chemical and radiochemical analysis. Laboratories need them for calibration and quality control throughout their analytical work. The IAEA started to produce reference materials in the early 1960s to meet the needs of the analytical laboratories in its Member States that required reference materials for quality control of their measurements. The initial efforts were focused on the preparation of environmental reference materials containing anthropogenic radionuclides for use by those laboratories employing nuclear analytical techniques. These reference materials were characterized for their radionuclide content through interlaboratory comparison involving a core group of some 10 to 20 specialist laboratories. The success of these early exercises led the IAEA to extend its activities to encompass both terrestrial and marine reference materials containing primordial radionuclides and trace elements. Today, the IAEA has more than 90 reference materials and maintains a customer base of about 5000 members from more than 85 Member States. Within the frame of IAEA activities in production and certification of RM, this report describes the certification of the IAEA 413: Major, minor and trace elements in algae. Details are given on methodologies and data evaluation

  17. Reference materials for nondestructive assay of special nuclear material. Volume 2. Thin metal foils of highly enriched uranium

    International Nuclear Information System (INIS)

    This report describes the fabrication of reference materials for use in gamma-ray-based nondestructive assay of small high-density uranium samples. The sample containers are small Petri dishes. The reference materials consist of thin circular discs of highly enriched uranium metal foil. The 235U content ranges from 0.2 to 10 g. The report also describes the assay procedure used with low-resolution detectors

  18. Embrapa's experience in the production and development of agriculture reference materials

    Science.gov (United States)

    Nogueira, A. R. A.; Souza, G. B.; Bossu, C. M.; Bianchi, S. R.; Verhalen, T. R.; Silva, P. T.; Peixoto, A. A. J.; Silva, C. S.

    2016-07-01

    The main challenge of Embrapa is to develop a model of genuine Brazilian tropical agriculture and livestock. To get this task, the quality of laboratories results is mandatory, increasing the demand for reference materials. Projects were proposed to produce reference materials to support the national agriculture laboratories and consolidate a network able to perform reliable and reproducible analytical testing laboratory within the internationally standards required. Reference materials were produced and available to interested laboratories and collaborative tests were conducted to obtain consensus values. The results and statistical evaluations were performed with the use of software developed by Embrapa Pecuaria Sudeste.

  19. Certified Rule Labeling

    OpenAIRE

    Nagele, Julian; Zankl, Harald

    2015-01-01

    The rule labeling heuristic aims to establish confluence of (left-)linear term rewrite systems via decreasing diagrams. We present a formalization of a confluence criterion based on the interplay of relative termination and the rule labeling in the theorem prover Isabelle. Moreover, we report on the integration of this result into the certifier CeTA, facilitating the checking of confluence certificates based on decreasing diagrams for the first time. The power of the method is illustrated by ...

  20. Development of an orange juice in-house reference material and its application to guarantee the quality of vitamin C determination in fruits, juices and fruit pulps.

    Science.gov (United States)

    Valente, A; Sanches-Silva, A; Albuquerque, T G; Costa, H S

    2014-07-01

    Reference materials are useful for the quality control of analytical procedures and to evaluate the performance of laboratories. There are few and expensive certified reference materials commercially available for vitamin C or ascorbic acid analysis in food matrices. In this study, the preparation and the suitability assessment of an orange juice in-house reference material (RM) for vitamin C analysis in fruits, juices and in fruit pulps is described. This RM was used for the development and full validation of an HPLC method. The results showed excellent linearity (r(2)=0.9995), good accuracy (96.6-97.3%) and precision, as relative standard deviation, ranged from 0.70% to 3.67%. The in-house RM was homogenous and stable at storage conditions (-80°C) during 12 months. According to our results, this in-house RM is an excellent tool to use in quality control and method verification purposes for vitamin C analysis of fruits, juices and fruit pulps matrices. Furthermore, a stabilization solution with perchloric and metaphosphoric acids was developed which prevents degradation of ascorbic acid for a period of 12 months at -80°C. PMID:24518317

  1. Development of an orange juice in-house reference material and its application to guarantee the quality of vitamin C determination in fruits, juices and fruit pulps.

    Science.gov (United States)

    Valente, A; Sanches-Silva, A; Albuquerque, T G; Costa, H S

    2014-07-01

    Reference materials are useful for the quality control of analytical procedures and to evaluate the performance of laboratories. There are few and expensive certified reference materials commercially available for vitamin C or ascorbic acid analysis in food matrices. In this study, the preparation and the suitability assessment of an orange juice in-house reference material (RM) for vitamin C analysis in fruits, juices and in fruit pulps is described. This RM was used for the development and full validation of an HPLC method. The results showed excellent linearity (r(2)=0.9995), good accuracy (96.6-97.3%) and precision, as relative standard deviation, ranged from 0.70% to 3.67%. The in-house RM was homogenous and stable at storage conditions (-80°C) during 12 months. According to our results, this in-house RM is an excellent tool to use in quality control and method verification purposes for vitamin C analysis of fruits, juices and fruit pulps matrices. Furthermore, a stabilization solution with perchloric and metaphosphoric acids was developed which prevents degradation of ascorbic acid for a period of 12 months at -80°C.

  2. Determination and Certification of Multielements in 6 Biological Reference Materials by NAA

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Food safety has been a problem of global concern. The insufficient availability of certificated reference materials (CRM) used for food analysis has resulted in a lack of internal quality control in food

  3. Normalization Methods and Selection Strategies for Reference Materials in Stable Isotope Analyes. Review

    International Nuclear Information System (INIS)

    Stable isotope ratio mass spectrometers are highly precise, but not accurate instruments. Therefore, results have to be normalized to one of the isotope scales (e.g., VSMOW, VPDB) based on well calibrated reference materials. The selection of reference materials, numbers of replicates, δ-values of these reference materials and normalization technique have been identified as crucial in determining the uncertainty associated with the final results. The most common normalization techniques and reference materials have been tested using both Monte Carlo simulations and laboratory experiments to investigate aspects of error propagation during the normalization of isotope data. The range of observed differences justifies the need to employ the same sets of standards worldwide for each element and each stable isotope analytical technique. (author)

  4. REFERENCE MATERIALS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Potala PalaceConstruction of the Potala Palace began in the mid-7th century for the Tubo King Songtsan Gambo to greet his Han wife, Princess Wencheng. It comprised 999 rooms then, plus one built atop the Red Hill, which, said to have 1,000 rooms, was later destroyed by thunderbolts and wars. What we see today is a structure built during the 17th century.In the mid-17th century, the White House was added to the Potala Palace, which spread along the Red Hill in Lhasa.The palace is a structure of clay, wood and stone. The palace was the residence of the Dalai Lama of various generations. Beginning with the period of the 5th Dalai Lama, major religious and political ceremonies were held there.The palace covers a total area of 360,000 square meters, with major building rising 117 meters high in 13 floors, and extends some 360 meters from east to west.From 1989 to 1994, the State earmarked some 55 million Yuan and large quantities of gold and silver to repair the palace.In December 1994, the palace found its w

  5. Evaluation of Botanical Reference Materials for the Determination of Vanadium in Biological Samples

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Damsgaard, Else

    1982-01-01

    Three botanical reference materials prepared by the National Bureau of Standards have been studied by neutron activation analysis to evaluate their suitability with respect to the determination of vanadium in biological samples. Various decomposition methods were applied in connection with chemic....... A reference value of 1.15 mg/kg of this material is recommended, based on results from 3 different methods. All three materials are preferable to SRM 1571 Orchard Leaves, while Bowen's Kale remains the material of choice because of its lower concentration....

  6. Neutron activation analysis of new botanical reference materials. Pt. 2. Evaluation of Czechoslovak green algae, lucerne, wheat and rye bread flour

    Energy Technology Data Exchange (ETDEWEB)

    Kucera, J.; Soukal, L. (Nuclear Research Inst., Rez (Czechoslovakia))

    1993-01-01

    The certified, information, and other values of elemental contents were compared with results of neutron activation analysis (NAA) for the new Czechoslovak botanical reference materials (RMs) Green Algae 12-02-02, Lucerne 12-02-03, Wheat Bread Fluor 12-02-04, and Rye Bread Flour 12-02-05. These were prepared by the Institute of Radioecology and Applied Nuclear Techniques (IRANT), Kosice, and statistically evaluated after interlaboratory comparisons. For the majority of elements, a very good agreement was found between the IRANT values and the results of NAA. In several cases, however, significant differences were detected; possible analytical reasons for the differences and the suitability of a purely statistical evaluation of intercomparison results without analytical considerations for RM certification are discussed. (orig.).

  7. 36 CFR 1254.64 - Will NARA certify copies?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Will NARA certify copies... Materials General Information § 1254.64 Will NARA certify copies? Yes, the responsible director of a unit... copies of documents as true copies for a fee. The fee is found at § 1258.12(a). Rules Relating to...

  8. 78 FR 58567 - Criteria to Certify Coal Mine Rescue Teams

    Science.gov (United States)

    2013-09-24

    ... Safety and Health Administration Criteria to Certify Coal Mine Rescue Teams AGENCY: Mine Safety and... mine rescue team training. MSHA prescribes training materials through the issuance of instruction guides. Existing standards for coal mine rescue teams include criteria for mine operators to certify...

  9. Biological and environmental reference materials for trace elements, nuclides and organic microcontaminants

    International Nuclear Information System (INIS)

    This report has been produced from a database on analytical reference materials of biological and environmental origin, which is maintained at the International Atomic Energy Agency. It is an updated version of an earlier report, published in 1985, which focussed mainly on reference materials for trace elements. In the present version of the report, reference materials for trace elements still constitute the major part of the data; however, information is also now included on a number of other selected analytes of relevance to IAEA programmes, i.e. radionuclides, stable isotopes and organic microcontaminants. The database presently contains 2,694 analyte values for 117 analytes in 116 biological and 77 environmental (non-biological) reference materials produced by 20 different suppliers. Additional information on the cost of the material, the unit size supplied, (weight or volume), and the minimum weight of material recommended for analysis is also provided (if available to the authors). It is expected that this report will help analysts to select the reference material that matches as closely as possible, with respect to matrix type and concentrations of the analytes of interest, the ''real'' samples that are to be analysed. Refs, 12 tabs

  10. Standard and reference materials for marine science. Third edition. Technical memo

    International Nuclear Information System (INIS)

    The third edition of the catalog of reference materials suited for use in marine science, originally compiled in 1986 for NOAA, IOC, and UNEP. The catalog lists close to 2,000 reference materials from sixteen producers and contains information about their proper use, sources, availability, and analyte concentrations. Indices are included for elements, isotopes, and organic compounds, as are cross references to CAS registry numbers, alternate names, and chemical structures of selected organic compounds. The catalog is being published independently by both NOAA and IOC/UNEP and is available from NOAA/NOS/ORCA in electronic form

  11. DGNB certified Healthcare Centres

    DEFF Research Database (Denmark)

    Brunsgaard, Camilla; Larsen, Tine Steen

    2015-01-01

    for sustainability and wants a certification. This research investigates the decision‐making and design process (DMaDP) behind four DGNB certified Healthcare Centres (HCC) in Northern Jutland in Denmark. In general, knowledge about the DMaDP is important. However it is important to know what part DGNB plays...... a dialog about DGNB and energy concept is important even before anyone start sketching. Experiences with the different approaches will be further outlined in the paper.Future research has the intention to collect further knowledge about DGNB and DMaDP in practise. This project was limited to Healthcare...

  12. Quantitative analysis of trace elements in environmental powders with laser ablation inductively coupled mass spectrometry using non-sample-corresponding reference materials for signal evaluation

    Science.gov (United States)

    Bauer, Gerald; Limbeck, Andreas

    2015-11-01

    Laser ablation inductively coupled plasma-mass spectrometry (LA-ICP-MS) is an attractive alternative to traditional procedures for the analysis of environmental samples (i.e., conventional liquid measurement after sample digestion). However, for accurate quantification, certified reference materials (CRM) are necessary which match the composition of the sample and include all elements of interest at the required concentration levels. The limited availability of appropriate CRMs hampers therefore substantial application. In this work, an LA-ICP-MS procedure allowing for accurate determination of trace element contents in powdered environmental samples is presented. For LA-ICP-MS analysis, the samples are mixed with an internal standard (silver oxide) and a binder (sodium tetra borate) and subsequently pressed to pellets. Quantification is accomplished using a calibration function determined using CRMs with varying matrix composition and analyte content, pre-treated and measured in the same way as the samples. With this approach, matrix-induced ablation differences resulting from varying physical/chemical properties of the individual CRMs could be compensated. Furthermore, ICP-related matrix-effects could be minimized using collision/reaction cell technology. Applicability of the procedure has been demonstrated by assessment of Cd, Cu, Ni, and Zn in four different environmental CRMs (NIST SRM1648a (urban particulate matter), NIST SRM2709 (San Joaquin Soil), BCR144 (sewage sludge), and BCR723 (road dust)). Signal evaluation was performed by alternative use of three CRMs for calculation of the calibration function whereas the remaining fourth CRM acted as unknown sample, resulting in a good agreement between measured and certified values for all elements and reference materials.

  13. Certificate of Analysis, Standard Reference Material® 1849, Infant/Adult Nutritional Formula

    Science.gov (United States)

    Standard Reference material (SRM) 1849 is intended primarily for validation of methods for determining proximates, fatty acids, vitamins, elements and nucleotides in infant and adult nutritional formulas and similar materials. This SRM can also be used for quality assurance when assigning values to ...

  14. A study of production of radioactive environmental reference materials used for proficiency testing program in Taiwan

    International Nuclear Information System (INIS)

    To realise radioactive environmental reference materials in Taiwan, seven environmental materials of soil, water, vegetation, meat, airborne particles (filter paper), milk and mushroom samples that are frequently encountered were used to establish the preparation of the reference materials. These seven environmental materials were collected, checked for freedom from radioactivity and prepared according to their properties. The preparation was carried out by using activity about 10–100 times that of the minimum detectable activity (MDA) in routine measurements in the radioactive standard used to spike the inactive material and this standard is traceable to national ionising radioactivity standards (TAF, 2004). To demonstrate sample traceability to the added standard, each sample was carefully measured and its uncertainty evaluated. Based on the recommendations of ISO Guide 35 for evaluation of reference materials and with the above assessment and verification procedures, the uncertainties (k=1) of the spike activity used in making reference materials were: 60Co≤4.6%, 134Cs≤4.7%, 137Cs≤5.0%, total β≤0.6% and 3H≤1.3%. - Highlights: • Seven kinds environmental materials were used to establish the production of the RMs. • Spiking the traceable standard radioactive source to the blank substance. • Each sample was carefully evaluated for its uncertainty. • The performance of the RMs was estimated with the Proficiency Testing program report. • The ability of the environment RMs in the configuration is quite good

  15. List of reference materials for non-destructive assay of U, Th and Pu isotopes

    International Nuclear Information System (INIS)

    A list of reference materials for non-destructive assay has been compiled within six countries of the EEC, the Commission and the IAEA with the assistance of the members of the Esarda working group on NDA. The reference materials have been tabulated according to the type of fuel cycle (HEU, LEU, Pu) and type of fuel. For each material the following data are given: the chemical composition, the nominal value or the range in quantity of the element, the U235 enrichment or isotopic composition, the physical form and number of pieces

  16. The use of BIM reference models for multi-material structural design

    OpenAIRE

    Djedović, Sanel

    2014-01-01

    Master thesis deals with multi-material structural design that is based on reference architectural model. We performed process and product analysis that is relevant for multi-material structural design and proposed and demonstrated its use for three construction materials (concrete, steel and wood) In the frames of process analysis we used IDEFØ methodology to describe AS-IS structural design. A detailed description of process models of existing design procedures for building permit and pr...

  17. Precise determination of silicon in ceramic reference materials by prompt gamma activation analysis at JRR-3

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Tsutomu [National Metrology Institute of Japan-AIST, Ibaraki (Japan); Matsue, Hideaki [Quantum Beam Science Directorate, Japan Atomic Energy Agency, Ibaraki (Japan)

    2016-04-15

    Prompt gamma activation analysis using a thermal neutron-guided beam at Japan Atomic Energy Agency JRR-3M was applied for the precise determination of Si in silicon nitride ceramic reference materials [Japan Ceramic Reference Material (JCRM) R 003]. In this study, the standard addition method coupled with internal standard was used for the nondestructive determination of Si in the sample. Cadmium was used as internal standard to obtain the linear calibration curves and to compensate for the neutron beam variability. The analytical result of determining Si in JCRM R 003 silicon nitride fine powder ceramic reference materials using prompt gamma activation analysis was in good agreement with that obtained by classical gravimetric analysis. The relative expanded measurement uncertainty (k = 2) associated with the determined value was 2.4%.

  18. Platinum stable isotope analysis of geological standard reference materials by double-spike MC-ICPMS

    DEFF Research Database (Denmark)

    Creech, John Benjamin; Baker, J. A.; Handler, M. R.;

    2014-01-01

    dissolved in acid in preparation for anion-exchange chemistry. Pt was recovered from anion-exchange resin in concentrated HNO acid after elution of matrix elements, including the other platinum group elements (PGE), in dilute HCl and HNO acids. The separation method has been calibrated using a precious...... metal standard solution doped with a range of synthetic matrices and results in Pt yields of ≥90% with purity of ≥95%. Using this chemical separation technique, we have separated Pt from 11 international geological standard reference materials comprising of PGE ores, mantle rocks, igneous rocks and one...... (Creech et al., 2013, J. Anal. At. Spectrom. 28, 853-865). The reproducibility in natural samples is evaluated by processing multiple replicates of four standard reference materials, and is conservatively taken to be ca. ±0.088 (2sd). Pt stable isotope data for the full set of reference materials have...

  19. Tailored graphitized soot as reference material for EC/OC measurement validation

    Directory of Open Access Journals (Sweden)

    O. Popovicheva

    2011-05-01

    Full Text Available The lack of standard reference materials for calibrating, troubleshooting and intercomparing techniques that measure the composition of black carbon, commonly referred to as soot, has been a major obstacle that hinders improved understanding of how climate and health is impacted by this ubiquitous component of the atmosphere. A different approach is offered here as a means of constructing precisely controlled material with fractions of organic carbon (OC on the surface of elemental carbon (EC whose structure reflects that of the combustion produced particles found in the atmosphere. The proposed soot reference material (SRM uses EC as a basis substrate for surface coatings of organic compounds that are representative of the main classes of organics identified in the coverage of soot produced by fossil fuel burning. A number of methods are used to demonstrate the quality and stability of the reference EC and SRM. Comparison of the nominal fraction of OC deposited on the EC substrate with the fraction measured with thermal/optical analysis (TOA shows excellent agreement. Application of this type of reference material for evaluating the different methods of carbon analysis may help resolve differences that currently exist between comparable measurement techniques when trying to separate OC and EC from ambient samples.

  20. Towards the development of standard reference materials for soot measurements – Part 1: Tailored graphitized soot

    Directory of Open Access Journals (Sweden)

    T. Khokhlova

    2010-04-01

    Full Text Available The lack of standard reference materials for calibrating, troubleshooting and intercomparing instruments that measure the properties of black carbon, commonly referred to as soot, has been a major obstacle that hinders improved understanding of how climate and health is impacted by this ubiquitous component of the atmosphere. A different approach is offered here as a means of constructing precisely controlled material with fractions of organic carbon (OC on the surface of elemental carbon (EC whose structure reflects that of combustion particles found in the atmosphere. The proposed soot reference material (SRM uses elemental carbon as a basis substrate for surface coatings of organic compounds that are representative of main classes of organics identified in the coverage of soot produced by fossil fuel burning. A number of methods are used to demonstrate the quality and stability of the reference EC and SRM. Comparison of the nominal fraction of OC deposited on the EC substrate with the fraction measured with thermal/optical analysis (TOA shows excellent agreement. Application of this type of reference material for evaluating the different methods of carbon analysis may help resolve differences that currently exist between comparable measurement techniques when trying to separate OC and EC from ambient samples.

  1. Assessment of international reference materials for isotope-ratio analysis (IUPAC Technical Report)

    Science.gov (United States)

    Brand, Willi A.; Coplen, Tyler B.; Vogl, Jochen; Rosner, Martin; Prohaska, Thomas

    2014-01-01

    Since the early 1950s, the number of international measurement standards for anchoring stable isotope delta scales has mushroomed from 3 to more than 30, expanding to more than 25 chemical elements. With the development of new instrumentation, along with new and improved measurement procedures for studying naturally occurring isotopic abundance variations in natural and technical samples, the number of internationally distributed, secondary isotopic reference materials with a specified delta value has blossomed in the last six decades to more than 150 materials. More than half of these isotopic reference materials were produced for isotope-delta measurements of seven elements: H, Li, B, C, N, O, and S. The number of isotopic reference materials for other, heavier elements has grown considerably over the last decade. Nevertheless, even primary international measurement standards for isotope-delta measurements are still needed for some elements, including Mg, Fe, Te, Sb, Mo, and Ge. It is recommended that authors publish the delta values of internationally distributed, secondary isotopic reference materials that were used for anchoring their measurement results to the respective primary stable isotope scale.

  2. A feasibility study for producing an egg matrix candidate reference material for the polyether ionophore salinomycin.

    Science.gov (United States)

    Ferreira, Rosana Gomes; Monteiro, Mychelle Alves; Pereira, Mararlene Ulberg; da Costa, Rafaela Pinto; Spisso, Bernardete Ferraz; Calado, Veronica

    2016-08-01

    The aim of this work was to study the feasibility of producing an egg matrix candidate reference material for salinomycin. Preservation techniques investigated were freeze-drying and spray drying dehydration. Homogeneity and stability studies of the produced batches were conducted according to ISO Guides 34 and 35. The results showed that all produced batches were homogeneous and both freeze-drying and spray drying techniques were suitable for matrix dehydrating, ensuring the material stability. In order to preserve the material integrity, it must be transported within the temperature range of -20 up to 25°C. The results constitute an important step towards the development of an egg matrix reference material for salinomycin is possible. PMID:27216677

  3. Testing of IAEA standard reference materials by Research and Development Institute, Czechoslovak Uranium Industry

    International Nuclear Information System (INIS)

    The Institute have partaken of attestations for a number of years. It has thus obtained a number of reference materials and could completely test the accuracy of the analytical methods used. The materials being tested included uranium and thorium ores, milk, whey, sea sediments and algae. The methods used included X-ray fluorescence analysis, high resolution gamma spectrometry, atomic absorption spectrometry, radiometric methods. Uranium was determined by spectrophotometry using Arsenazo III. (M.D.). 2 tabs., 17 refs

  4. Combating illicit trafficking in nuclear and other radioactive material. Reference material

    International Nuclear Information System (INIS)

    This publication is intended for individuals and organizations that may be called upon to deal with the detection of and response to criminal or unauthorized acts involving nuclear or other radioactive material. It will also be useful for legislators, law enforcement agencies, government officials, technical experts, lawyers, diplomats and users of nuclear technology. This manual emphasizes the international initiatives for improving the security of nuclear and other radioactive material. However, it is recognized that effective measures for controlling the transfer of equipment, non-nuclear material, technology or information that may assist in the development of nuclear explosive devices, improvised nuclear devices (INDs) or other radiological dispersal devices (RDDs) are important elements of an effective nuclear security system. In addition, issues of personal integrity, inspection and investigative procedures are not discussed in this manual, all of which are essential elements for an effective overall security system. The manual considers a variety of elements that are recognized as being essential for dealing with incidents of criminal or unauthorized acts involving nuclear and other radioactive material. Depending on conditions in a specific State, including its legal and governmental infrastructure, some of the measures discussed will need to be adapted to suit that State's circumstances. However, much of the material can be applied directly in the context of other national programmes. This manual is divided into four main parts. Section 2 discusses the threat posed by criminal or unauthorized acts involving nuclear and other radioactive material, as well as the policy and legal bases underlying the international effort to restrain such activities. Sections 3 and 4 summarize the major international undertakings in the field. Sections 5-8 provide some basic technical information on radiation, radioactive material, the health consequences of radiation

  5. PAHs in baby food: assessment of three different processing techniques for the preparation of reference materials.

    Science.gov (United States)

    Huertas-Pérez, José Fernando; Bordajandi, Luisa R; Sejerøe-Olsen, Berit; Emteborg, Håkan; Baù, Andrea; Schimmel, Heinz; Dabrio, Marta

    2015-04-01

    A feasibility study for producing a matrix reference material for selected polycyclic aromatic hydrocarbons (PAHs) in baby food is reported. A commercially available baby food, containing carrots, potatoes, tomato, white beans and meat, was spiked with the so-called 15 + 1 PAHs included in the PAHs priority list for food of the EU, at a mass fraction level of 1 μg/kg. The contaminated baby food was further processed by autoclaving, freezing or freeze drying. The homogeneity of the three materials (bottle-to-bottle variation) and their short-term (4 weeks) and long-term (18 months) stability at different temperatures were assessed. To this end, an analytical method based on a solid-liquid extraction followed by cleaning up with gel permeation chromatography (GPC) and solid phase extraction (SPE) and GC-IDMS determination, was validated in-house. It could be demonstrated that the procedure fulfilled the demands for application to the homogeneity and isochronous stability studies for the candidate reference materials targeted here. All three materials proved to be sufficiently homogeneous for the intended use. Measurements on the autoclaved material provided the most promising results in terms of envisaged shelf life, although freeze drying was also found to be a suitable processing technique for most of the investigated PAHs. These results are an important step towards the development of a matrix reference material for PAHs in a processed food matrix in a presentation very similar to routine samples.

  6. Doorways III: Teacher Reference Materials. On School-Related Gender-Based Violence Prevention and Response

    Science.gov (United States)

    US Agency for International Development, 2009

    2009-01-01

    The Doorways training program was designed by the U.S. Agency for International Development (USAID)-funded Safe Schools Program (Safe Schools) to enable teachers, community members and students to prevent and respond to school-related gender-based violence (SRGBV). This booklet, "Doorways III: Teacher Reference Materials on School-Related…

  7. The preparation of a reference material of South African zirconium concentrate from Richards Bay

    International Nuclear Information System (INIS)

    This report describes the preparation of a South African zirconium concentrate as an inernational reference material. The procedure for the selection of preferred values is outlined. Eleven laboratories contributed to the analytical programme, and 7 elements have been asssigned preferred values

  8. Future needs and requirements for AMS C-14 standards and reference materials

    NARCIS (Netherlands)

    Scott, EM; Boaretto, E; Bryant, C; Cook, GT; Gulliksen, S; Harkness, DD; Heinemeier, J; McGee, E; Naysmith, P; Possnert, G; van der Plicht, H; van Strydonck, M; Cook, Gordon T.

    2004-01-01

    C-14 measurement uses a number of standards and reference materials with different properties. Historically the absolute calibration of C-14 measurement was tied to 1890 wood, through the 'primary' standard of NBS-OxI (produced by the National Bureau of Standards, now NIST - National Institute of St

  9. Compilation of elemental concentration data for NBS Biological and Environmental Standard Reference Materials

    International Nuclear Information System (INIS)

    Concentration data on up to 76 elementals in 19 NBS Standard Reference Materials have been collected from 325 journal articles and technical reports. These data are summarized into mean +- one standard deviation values and compared with available data from NBS and other review articles. Data are presented on the analytical procedures employed and all raw data are presented in appendixes

  10. Characterizing a full spectrum of physico-chemical properties of ginsenosides rb1 and rg1 to be proposed as standard reference materials.

    Science.gov (United States)

    Kim, Il-Woung; Hong, Hee-Do; Choi, Sang Yoon; Hwang, Da-Hye; Her, Youl; Kim, Si-Kwan

    2011-11-01

    Good manufacturing practice (GMP)-based quality control is an integral component of the common technical document, a formal documentation process for applying a marketing authorization holder to those countries where ginseng is classified as a medicine. In addition, authentication of the physico-chemical properties of ginsenoside reference materials, and qualitative and quantitative batch analytical data based on validated analytical procedures are prerequisites for certifying GMP. Therefore, the aim of this study was to propose an authentication process for isolated ginsenosides Rb1 and Rg1 as reference materials (RM) and for these compounds to be designated as RMs for ginseng preparations throughout the world. Ginsenoside Rb1 and Rg1 were isolated by Diaion HP-20 adsorption chromatography, silica gel flash chromatography, recrystallization, and preparative HPLC. HPLC fractions corresponding to those two ginsenosides were recrystallized in appropriate solvents for the analysis of physico-chemical properties. Documentation of the isolated ginsenosides was made according to the method proposed by Gaedcke and Steinhoff. The ginsenosides were subjected to analyses of their general characteristics, identification, purity, content quantitation, and mass balance tests. The isolated ginsenosides were proven to be a single compound when analyzed by three different HPLC systems. Also, the water content was found to be 0.940% for Rb1 and 0.485% for Rg1, meaning that the net mass balance for ginsenoside Rb1 and Rg1 were 99.060% and 99.515%, respectively. From these results, we could assess and propose a full spectrum of physicochemical properties for the ginsenosides Rb1 and Rg1 as standard reference materials for GMP-based quality control.

  11. Survey of inorganic arsenic in marine animals and marine certified reference materials by anion exchange high-performance liquid chromatography-inductively coupled plasma mass spectrometry

    DEFF Research Database (Denmark)

    Sloth, Jens Jørgen; Larsen, Erik Huusfeldt; Julshamn, Kåre

    2005-01-01

    A method for the determination of inorganic arsenic in seafood samples using high-performance liquid chromatography-inductively coupled plasma mass spectrometry is described. The principle of the method relied on microwave-assisted alkaline dissolution of the sample, which at the same time oxidized...... arsenite [As(Ill)] to arsenate [As(V)], whereby inorganic arsenic could be determined as the single species As(V). Anion exchange chromatography using isocratic elution with aqueous ammonium carbonate as the mobile phase was used for the separation of As(V) from other coextracted organoarsenic compounds...

  12. Reference methods and materials. A programme of support for regional and global marine pollution assessments

    International Nuclear Information System (INIS)

    This document describes a programme of comprehensive support for regional and global marine pollution assessments developed by the United Nations Environment Programme (UNEP) in cooperation with the International Atomic Energy Agency (IAEA) and the Intergovernmental Oceanographic Commission (IOC) and with the collaboration of a number of other United Nations Specialized agencies including the Food and Agriculture Organisation (FAO), the World Meteorological Organisation (WMO), the World Health Organisation (WHO) and the International Maritime Organisation (IMO). Two of the principle components of this programme, Reference Methods and Reference materials are given special attention in this document and a full Reference Method catalogue is included, giving details of over 80 methods currently available or in an advanced stage of preparation and testing. It is important that these methods are seen as a functional component of a much wider strategy necessary for assuring good quality and intercomparable data for regional and global pollution monitoring and the user is encouraged to read this document carefully before employing Reference Methods and Reference Materials in his/her laboratory. 3 figs

  13. Determination of operationally defined fractions of aluminium in reference materials and acid attacked environmental samples

    International Nuclear Information System (INIS)

    The aim of the presented work is to evaluate the selectivity of the operationally defined procedures for the aluminium fractionation in the reference materials and the environmental samples affected by the mining activity. The combination of the sequential optimized BCR (European Commission Community Bureau of Reference) three-step, the single (H2O, CaCl2, Na2S2O4, NH4F (NH4)2C2O4, HCl, NTA, EDTA, DTPA) and the solid phase chelating ion-exchange extraction procedures was performed for the aluminium fractionation in the samples. The amount of the reactive Al determined by the solid phase extraction on the chelating resin Iontosorb Salicyl is the most important operationally defined fraction of aluminium from the aspect of its negative effects on the environment. The available Al concentrations obtained from the different operationally defined fractionation methods were compared. The flame atomic absorption spectrometry was used for the aluminium quantification. The X-ray diffraction analyse of the samples was performed for the mineral composition determination. The precision, the repeatability and the accuracy for the all steps of the optimized BCR sequential extraction procedure were checked on six reference materials (SRM 2710, RSS SO-2, RSS SO-4, CRM SA-B, SRM RTH 912, CRM 025-050). The precision and the repeatability were very good with the R.S.D. values 11%. The fraction specific accuracy was excellent. The new indicative fractional Al values in the used reference materials are published

  14. Present status and strategic plan for the stable isotope reference materials at the IAEA.

    Science.gov (United States)

    Assonov, Sergey; Groening, Manfred

    2016-04-01

    The presentation will give the overview of the stable isotope reference materials (SI-RMs) under distribution by the IAEA, its stable isotope laboratory and capacities related to material testing & production as well as future plans. Historically, most of the IAEA reference materials were produced and made available via collaborations with expert stable isotope laboratories worldwide. The IAEA plans include several directions as follows: • Maintaining the scale-defining SI-RMs at the highest level and introducing adequate replacements when needed; • Monitoring existing SI-RMs for any potential alteration(s) and of isotopic values assigned; • Identifying and then addressing the needs for new SI-RMs, with the priority to address the most critical applications (environmental and climate related applications, human health, food safety studies) and newly emerging analytical isotope techniques; • Performing all measurements aimed for characterisation of new SI-RMs and the corresponding uncertainty evaluation in accordance to the latest metrological concepts; • Promoting metrological approaches on traceability and uncertainty evaluation in every day practice of stable isotope measurements; • Expanding the IAEA capacities for SI-RMs by (i) planning a renewed laboratory at IAEA; (ii) enlarging collaboration with expert laboratories aimed to help IAEA in production and characterisation of new SI-RMs. These major directions will help to address the increasing demand for Stable Isotope Reference Materials.

  15. Using a Materials Database System as the Backbone for a Certified Quality System (AS/NZS ISO 9001:1994) for a Distance Education Centre.

    Science.gov (United States)

    Hughes, Norm

    The Distance Education Center (DEC) of the University of Southern Queensland (Australia) has developed a unique materials database system which is used to monitor pre-production, design and development, production and post-production planning, scheduling, and distribution of all types of materials including courses offered only on the Internet. In…

  16. ENERGY STAR Certified Ceiling Fans

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Ceiling Fans that are effective as of April 1,...

  17. ENERGY STAR Certified Ventilating Fans

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 4.0 ENERGY STAR Program Requirements for Ventilating Fans that are effective as of...

  18. ENERGY STAR Certified Residential Dishwashers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 6.0 ENERGY STAR Program Requirements for Residential Dishwashers that are effective as...

  19. ENERGY STAR Certified Commercial Fryers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Commercial Fryers that are effective as of...

  20. ENERGY STAR Certified Audio Video

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Audio Video Equipment that are effective as of...

  1. ENERGY STAR Certified Commercial Dishwashers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Commercial Dishwashers that are effective as of...

  2. ENERGY STAR Certified Imaging Equipment

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Imaging Equipment that are effective as of...

  3. ENERGY STAR Certified Water Coolers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Water Coolers that are effective as of February...

  4. ENERGY STAR Certified Water Heaters

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Water Heaters that are effective April 16,...

  5. ENERGY STAR Certified Roof Products

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.3 ENERGY STAR Program Requirements for Roof Products that are effective as of July 1,...

  6. ENERGY STAR Certified Vending Machines

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Refrigerated Beverage Vending Machines that are...

  7. Microwave-assisted extraction and quantitative LC/ID-MS measurement of total choline and free carnitine in food standard reference materials.

    Science.gov (United States)

    Phillips, Melissa M; Sander, Lane C

    2012-01-01

    The Stakeholder Panel on Infant Formula and Adult Nutritionals of AOAC INTERNATIONAL has declared both choline and carnitine to be priority nutrients in infant formulas, and ongoing efforts exist to develop or improve Official Methods of Analysis for these nutrients. As a result, matrix-based certified reference materials are needed with assigned values for these compounds. In this work, traditional acid and enzymatic hydrolysis procedures were compared to microwave-assisted acid hydrolysis, and conditions optimized to provide complete sample hydrolysis and recovery of total choline from four food standard reference materials (SRMs): whole milk powder, whole egg powder, infant formula, and soy flour. The extracts were analyzed using LC on a mixed-mode column (simultaneous RP and ion exchange) with isotope dilution-MS detection to achieve simultaneous quantification of total choline and free carnitine. Total choline has been determined in these four food matrixes with excellent precision (0.65 to 2.60%) and accuracy, as confirmed by use of SRM 1849 Infant/Adult Nutritional Formula as a control material. Free carnitine has been determined in two of these food matrixes with excellent precision (0.69 to 2.19%) and accuracy, as confirmed by use of SRM 1849 Infant/Adult Nutritional Formula as a control material. Limitations in simultaneous determination of total choline and free carnitine resulted from extreme differences in concentration of the two components in egg powder and soy flour (at least three orders of magnitude). Samples required dilution to prevent poor LC peak shape, which caused decreased precision in the determination of low concentrations of free carnitine. Despite this limitation, the described method yields results comparable to current AOAC Official Method 999.14 Choline in Infant Formula, with a decrease of more than 2 h in sample preparation time. PMID:23175983

  8. Homogeneity study on biological candidate reference materials: the role of neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Daniel P.; Moreira, Edson G., E-mail: dsilva.pereira@usp.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    Instrumental Neutron activation Analysis (INAA) is a mature nuclear analytical technique able to accurately determine chemical elements without the need of sample digestion and, hence, without the associated problems of analyte loss or contamination. This feature, along with its potentiality use as a primary method of analysis, makes it an important tool for the characterization of new references materials and in the assessment of their homogeneity status. In this study, the ability of the comparative method of INAA for the within-bottle homogeneity of K, Mg, Mn and V in a mussel reference material was investigated. Method parameters, such as irradiation time, sample decay time and distance from sample to the detector were varied in order to allow element determination in subsamples of different sample masses in duplicate. Sample masses were in the range of 1 to 250 mg and the limitations of the detection limit for small sample masses and dead time distortions for large sample masses were investigated. (author)

  9. Evaluation of the Community's research programme ''Nuclear measurements and reference materials'' (1980-1985)

    International Nuclear Information System (INIS)

    A panel has evaluated the research programme ''Nuclear measurements and reference materials'' performed by JRC-Geel, CBNM (Central Bureau for Nuclear Measurements) during the period 1980-85. Furthermore the panel has considered more general topics such as major facilities, staff and collaboration between JRC-Geel, CBNM and other organizations. Finally, the panel has discussed the future direction of the programme. The panel expressed its satisfaction with the scientific and technical quality of the work and recommended that JRC-Geel, CBNM should continue to play an important role in Europe in the fields of nuclear measurements and nuclear reference materials. The panel also recommended that the underlying research be strengthened and that the nuclear experience and expertise of JRC-Geel, CBNM be utilized for non-nuclear applications

  10. Novel application of high pressure processing for the production of shellfish toxin matrix reference materials.

    Science.gov (United States)

    Turner, Andrew D; Powell, Andy L; Burrell, Stephen

    2014-11-01

    The production of homogeneous and stable matrix reference materials for marine biotoxins is important for the validation and implementation of instrumental methods of analysis. High pressure processing was investigated to ascertain potential advantages this technique may have in stabilising paralytic shellfish poisoning toxins in shellfish tissues compared to untreated materials. Oyster tissues were subjected to a range of different temperatures and pressures, with results showing a significant reduction in biological activity in comparison to control samples, without significantly altering toxin profiles. Tissue subjected to pressures >600 MPa at 50 °C was assessed for homogeneity and stability. The sample homogeneity was determined using a pre-column oxidation LC-FLD method and shown to be within accepted levels of within batch repeatability. Short and long-term stability studies were conducted over a range of temperatures, with analysis by pre and post column oxidation LC-FLD demonstrating improved stability of toxins compared to the untreated materials and with epimerisation of toxins also notably reduced in treated materials. This study confirmed the technique of high pressure processing to improve the stability of PSP toxins compared to untreated wet tissues and highlighted its applicability in reference material preparation where removal of biological activity is of importance.

  11. Software Management Environment (SME) release 9.4 user reference material

    Science.gov (United States)

    Hendrick, R.; Kistler, D.; Manter, K.

    1992-01-01

    This document contains user reference material for the Software Management Environment (SME) prototype, developed for the Systems Development Branch (Code 552) of the Flight Dynamics Division (FDD) of Goddard Space Flight Center (GSFC). The SME provides an integrated set of management tools that can be used by software development managers in their day-to-day management and planning activities. This document provides an overview of the SME, a description of all functions, and detailed instructions concerning the software's installation and use.

  12. The NIMROC reference materials: revised values for thorium, yttrium, lanthanum, and the rare-earth elements

    International Nuclear Information System (INIS)

    This report gives all the analytical results submitted by the contributing laboratories before July 1983 for thorium, yttrium, lanthanum, and the rare-earth elements in the six NIMROC reference materials (SARM 1 to 6), which were prepared in 1966 by the former National Institute for Metallurgy, now the Council for Mineral Technology (Mintek). The statistical evaluation of these results and the assignment of new or revised recommended or provisional values are described

  13. The role of adequate reference materials in density measurements in hemodialysis

    Science.gov (United States)

    Furtado, A.; Moutinho, J.; Moura, S.; Oliveira, F.; Filipe, E.

    2015-02-01

    In hemodialysis, oscillation-type density meters are used to measure the density of the acid component of the dialysate solutions used in the treatment of kidney patients. An incorrect density determination of this solution used in hemodialysis treatments can cause several and adverse events to patients. Therefore, despite the Fresenius Medical Care (FME) tight control of the density meters calibration results, this study shows the benefits of mimic the matrix usually measured to produce suitable reference materials for the density meter calibrations.

  14. A reference material for establishing uncertainties in full-field displacement measurements

    International Nuclear Information System (INIS)

    A simple reference material for establishing the minimum measurement uncertainty of optical systems for measuring 3D surface displacement fields in deforming objects is described and its use demonstrated by employing 3D digital image correlation as an exemplar technique. The reference material consists of a stepped bar, whose dimensions can be scaled to suit the application, and that can be clamped rigidly at its thick end to create an idealized cantilever. The cantilever was excited at resonance to generate out-of-plane displacements and, in a separate experiment, loaded statically in-plane to provide in-plane displacement fields. The displacements were measured using 3D digital image correlation and compared to the predicted displacement fields derived from tip deflections obtained using a calibrated transducer that provided traceability to the national standard for length. The minimum measurement uncertainties were evaluated by comparing the measured and predicted displacement fields, taking account of the uncertainties in the input parameters for the predictions. It was found that the minimum measurement uncertainties were less than 3% for the Cartesian components of displacement present during static in-plane bending and less than 3 µm for out-of-plane displacements during dynamic loading. It was concluded that this reference material was more straightforward to use, more versatile and yielded comparable results relative to an earlier design. (paper)

  15. 地下水中砷形态标准物质研制%The Development of Arsenic Speciation Reference Material in Ground Water

    Institute of Scientific and Technical Information of China (English)

    袁建; 王亚平; 许春雪; 代阿芳; 王苏明; 安子怡

    2012-01-01

    Arsenic is widely found in nature. Different speciations have different toxicity, for example the toxicity of inorganic arsenic is larger than that of organic arsenic. Therefore, accurate determination of arsenic speciation in water, especially ground water, has important significance for human health and environmental protection. However, there is no arsenic speciation standard reference either nationally or internationally. To this end, five reference materials for arsenic speciation have been developed, which were collected from Shanxi Province and Nei Monggol, typical areas with a high background of arsenic. During collection and preparation of the samples, lyopyilization and protectant were used to ensure stability of the arsenic speciation. The certified content values of total arsenic, As( IE) and As ( V ) were obtained by Atomic Fluorescence Spectrometry ( AFS), Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES), Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and High Performance Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometry ( HPLC-ICPMS). The analytical results indicate that the reference materials were homogeneous and stable. A multi-laboratory collaborative analysis scheme was adopted in the certification procedure. The determination methods were accurate and reliable with reasonable certified values and uncertainties. Moreover, lyopyilization, which is commonly used in the medical profession in order to guarantee the sample stability, was primarily applied to the preparation of the standard reference materials. This series of reference materials fills the gaps at national and international levels.%砷元素的不同形态对人体有不同的毒性,无机砷的毒性最大,有机砷毒性较小,准确测定水体中尤其是地下水中砷形态的含量对于人体健康和环境保护有重要意义.但目前国内外尚缺乏地下水中砷形态的标准物质.文章研制了5个地下水砷形态标准物

  16. Developing a reference material for diffusion-controlled formaldehyde emissions testing.

    Science.gov (United States)

    Liu, Zhe; Liu, Xiaoyu; Zhao, Xiaomin; Cox, Steven S; Little, John C

    2013-11-19

    Formaldehyde, a known human carcinogen and mucous membrane irritant, is emitted from a variety of building materials and indoor furnishings. The drive to improve building energy efficiency by decreasing ventilation rates increases the need to better understand emissions from indoor products and to identify and develop lower emitting materials. To help meet this need, formaldehyde emissions from indoor materials are typically measured using environmental chambers. However, chamber testing results are frequently inconsistent and provide little insight into the mechanisms governing emissions. This research addresses these problems by (1) developing a reference formaldehyde emissions source that can be used to validate chamber testing methods for characterization of dynamic sources of formaldehyde emissions and (2) demonstrating that emissions from finite formaldehyde sources can be predicted using a fundamental mass-transfer model. Formaldehyde mass-transfer mechanisms are elucidated, providing practical approaches for developing diffusion-controlled reference materials that mimic actual sources. The fundamental understanding of emissions mechanisms can be used to improve emissions testing and guide future risk reduction actions. PMID:24102115

  17. Developing a reference material for diffusion-controlled formaldehyde emissions testing.

    Science.gov (United States)

    Liu, Zhe; Liu, Xiaoyu; Zhao, Xiaomin; Cox, Steven S; Little, John C

    2013-11-19

    Formaldehyde, a known human carcinogen and mucous membrane irritant, is emitted from a variety of building materials and indoor furnishings. The drive to improve building energy efficiency by decreasing ventilation rates increases the need to better understand emissions from indoor products and to identify and develop lower emitting materials. To help meet this need, formaldehyde emissions from indoor materials are typically measured using environmental chambers. However, chamber testing results are frequently inconsistent and provide little insight into the mechanisms governing emissions. This research addresses these problems by (1) developing a reference formaldehyde emissions source that can be used to validate chamber testing methods for characterization of dynamic sources of formaldehyde emissions and (2) demonstrating that emissions from finite formaldehyde sources can be predicted using a fundamental mass-transfer model. Formaldehyde mass-transfer mechanisms are elucidated, providing practical approaches for developing diffusion-controlled reference materials that mimic actual sources. The fundamental understanding of emissions mechanisms can be used to improve emissions testing and guide future risk reduction actions.

  18. Quality assessment of organic coffee beans for the preparation of a candidate reference material

    International Nuclear Information System (INIS)

    A random sampling was carried out in the coffee beans collected for the preparation of the organic green coffee reference material in view of assessing the homogeneity and the presence of soil as impurity. Fifteen samples were taken for the between-sample homogeneity evaluation. One of the samples was selected and 10 test portions withdrawn for the within-sample homogeneity evaluation. Br, Ca, Co, Cs, Fe, K, Na, Rb, Sc and Zn were determined by instrumental neutron activation analysis (INAA). The F-test demonstrated that the material is homogeneous for Ca, Co, Cs, K and Sc, but not homogeneous for Br, Fe, Na, Rb and Zn. Results of terrigenous elements suggested negligible soil contamination in the raw material. (author)

  19. Reference Material Kydex(registered trademark)-100 Test Data Message for Flammability Testing

    Science.gov (United States)

    Engel, Carl D.; Richardson, Erin; Davis, Eddie

    2003-01-01

    The Marshall Space Flight Center (MSFC) Materials and Processes Technical Information System (MAPTIS) database contains, as an engineering resource, a large amount of material test data carefully obtained and recorded over a number of years. Flammability test data obtained using Test 1 of NASA-STD-6001 is a significant component of this database. NASA-STD-6001 recommends that Kydex 100 be used as a reference material for testing certification and for comparison between test facilities in the round-robin certification testing that occurs every 2 years. As a result of these regular activities, a large volume of test data is recorded within the MAPTIS database. The activity described in this technical report was undertaken to mine the database, recover flammability (Test 1) Kydex 100 data, and review the lessons learned from analysis of these data.

  20. On the status of IAEA delta-13C stable isotope reference materials.

    Science.gov (United States)

    Assonov, Sergey; Groening, Manfred; Fajgelj, Ales

    2016-04-01

    For practical reasons all isotope measurements are performed on relative scales realized through the use of international, scale-defining primary standards. In fact these standards were materials (artefacts, similar to prototypes of meter and kg) selected based on their properties. The VPDB delta-13C scale is realised via two highest-level reference materials NBS19 and LSVEC, the first defining the scale and the second aimed to normalise lab-to-lab calibrations. These two reference materials (RMs) have been maintained and distributed by IAEA and NIST. The priority task is to maintain these primary RMs at the required uncertainty level, thus ensuring the long-term scale consistency. The second task is to introduce replacements when needed (currently for exhausted NBS19, work in progress). The next is to produce a family of lower level RMs (secondary, tertiary) addressing needs of various applications (with different delta values, in different physical-chemical forms) and their needs for the uncertainty; these RMs should be traceable to the highest level RMs. Presently three is a need for a range of RMs addressing existing and newly emerging analytical techniques (e.g. optical isotopic analysers) in form of calibrated CO2 gases with different delta-13C values. All that implies creating a family of delta-13C stable isotope reference materials. Presently IAEA works on replacement for NBS19 and planning new RMs. Besides, we found that LSVEC (introduced as second anchor for the VPDB scale in 2006) demonstrate a considerable scatter of its delta-13C value which implies a potential bias of the property value and increased value uncertainty which may conflict with uncertainty requirements for atmospheric monitoring. That is not compatible with the status of LSVEC, and therefore it should be replaced as soon as possible. The presentation will give an overview of the current status, the strategic plan of developments and the near future steps.

  1. Biological reference materials for quality control of elemental composition analytical data

    International Nuclear Information System (INIS)

    Twelve biological-matrix, agricultural/food reference materials, Corn Stalk (Zea Mays) (NIST RM 8412), Corn Kernel (Zea Mays) (NIST RM 8413), Bovine Muscle Powder (NIST RM 8414), Whole Egg Powder (NIST RM 8415), Microcrystalline Cellulose (NIST RM 8416), Wheat Gluten (NIST RM 8418), Corn Starch (NIST RM 8432), Corn Bran (NIST RM 8433), Whole Milk Powder (NIST RM 8435), Durum Wheat Flour (NIST RM 8436), Hard Red Spring Wheat Flour (NIST RM 8437) and Soft Winter Wheat Flour (NIST RM 8438) were developed. They were characterized with respect to elemental composition via two extensive international interlaboratory characterization campaigns providing 303 reference and informational concentration values for 34 elements (Al, As, B, Ba, Br, Ca, Cd, Cl, Co, Cr, Cs, Cu, F, Fe, Hg, I, K, Mg, Mn, Mo, N, Na, Ni, P, Pb, Rb, S, Sb, Se, Sr, Ti, V, W, Zn) of nutritional, toxicological, and environmental significance. These products are available to the analytical community, for quality control of elemental composition analytical data, from the Standard Reference Materials Program, National Institute of Standards and Technology, Gaithersburg, MD, USA. (author)

  2. Reference waste forms and packing material for the Nevada Nuclear Waste Storage Investigations Project

    International Nuclear Information System (INIS)

    The Lawrence Livermore National Laboratory (LLNL), Livermore, Calif., has been given the task of designing and verifying the performance of waste packages for the Nevada Nuclear Waste Storage Investigations (NNWSI) Project. NNWSI is studying the suitability of the tuffaceous rocks at Yucca Mountain, Nevada Test Site, for the potential construction of a high-level nuclear waste repository. This report gives a summary description of the three waste forms for which LLNL is designing waste packages: spent fuel, either as intact assemblies or as consolidated fuel pins, reprocessed commercial high-level waste in the form of borosilicate glass, and reprocessed defense high-level waste from the Defense Waste Processing Facility in Aiken, S.C. Reference packing material for use with the alternative waste package design for spent fuel is also described. 14 references, 8 figures, 20 tables

  3. Standard reference material certification: contribution of NAA with a TRIGA reactor

    International Nuclear Information System (INIS)

    Pavia has cooperative links with the major international agencies devoted to the certification of SRMs or CRMs as the Bureau Communautaire de Reference (BCR), the European Institute for Reference Materials and Measurement (IRMM), the USA National Institute of Standards and Technology (NIST) and the International Atomic Energy Agency (IAEA). During these cooperative works, a large amount of analytical data obtained with NAA has been compared, and meaningful methodological information achieved with respect to accuracy and precision in the analysis of several elements at different concentrations in various matrices. Analytical data on As, Cd, Cr, Co, Cu, Cs, Fe, Zn, K, Sc, U, Th, Al, Sb, Mn, V, Hg, Sr, Rb, Se,Pt, all the Rare Earths and halogens Br, Cl, I, have been obtained and contributed for the final certification

  4. Short-term stability test for thorium soil candidate a reference material

    Energy Technology Data Exchange (ETDEWEB)

    Clain, Almir F.; Fonseca, Adelaide M.G.; Dantas, Vanessa V.D.B.; Braganca, Maura J.C.; Souza, Poliana S., E-mail: almir@ird.gov.br, E-mail: adelaide@ird.gov.br, E-mail: vanessa@ird.gov.br, E-mail: maura@ird.gov.br, E-mail: poliana@bolsista.ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    This work describes a methodology to determine the soil short-term stability after the steps of production in laboratory. The short-term stability of the soil is an essential property to be determined in order to producing a reference material. The soil is a candidate of reference material for chemical analysis of thorium with metrological traceability to be used in environmental analysis, equipment calibration, validation methods, and quality control. A material is considered stable in a certain temperature if the property of interest does not change with time, considering the analytical random fluctuations. Due to this, the angular coefficient from the graphic of Th concentration versus elapsed time must be near to zero. The analytical determinations of thorium concentration were performed by Instrumental Neutron activation Analysis. The slopes and their uncertainties were obtained from the regression lines at temperatures of 20 deg C and 60 deg C, with control temperature of -20 deg C. From the obtained data a t-test was applied. In both temperatures the calculated t-value was lower than the critical value, so we can conclude with 95% confidence level that no significant changes happened during the period studied concerning thorium concentration in soil at temperatures of 20 deg C and 60 deg C, showing stability at these temperatures. (author)

  5. Results of a Saxitoxin Proficiency Test Including Characterization of Reference Material and Stability Studies

    Directory of Open Access Journals (Sweden)

    Kirsi Harju

    2015-11-01

    Full Text Available A saxitoxin (STX proficiency test (PT was organized as part of the Establishment of Quality Assurance for the Detection of Biological Toxins of Potential Bioterrorism Risk (EQuATox project. The aim of this PT was to provide an evaluation of existing methods and the European laboratories’ capabilities for the analysis of STX and some of its analogues in real samples. Homogenized mussel material and algal cell materials containing paralytic shellfish poisoning (PSP toxins were produced as reference sample matrices. The reference material was characterized using various analytical methods. Acidified algal extract samples at two concentration levels were prepared from a bulk culture of PSP toxins producing dinoflagellate Alexandrium ostenfeldii. The homogeneity and stability of the prepared PT samples were studied and found to be fit-for-purpose. Thereafter, eight STX PT samples were sent to ten participating laboratories from eight countries. The PT offered the participating laboratories the possibility to assess their performance regarding the qualitative and quantitative detection of PSP toxins. Various techniques such as official Association of Official Analytical Chemists (AOAC methods, immunoassays, and liquid chromatography-mass spectrometry were used for sample analyses.

  6. Short-term stability test for thorium soil candidate a reference material

    International Nuclear Information System (INIS)

    This work describes a methodology to determine the soil short-term stability after the steps of production in laboratory. The short-term stability of the soil is an essential property to be determined in order to producing a reference material. The soil is a candidate of reference material for chemical analysis of thorium with metrological traceability to be used in environmental analysis, equipment calibration, validation methods, and quality control. A material is considered stable in a certain temperature if the property of interest does not change with time, considering the analytical random fluctuations. Due to this, the angular coefficient from the graphic of Th concentration versus elapsed time must be near to zero. The analytical determinations of thorium concentration were performed by Instrumental Neutron activation Analysis. The slopes and their uncertainties were obtained from the regression lines at temperatures of 20 deg C and 60 deg C, with control temperature of -20 deg C. From the obtained data a t-test was applied. In both temperatures the calculated t-value was lower than the critical value, so we can conclude with 95% confidence level that no significant changes happened during the period studied concerning thorium concentration in soil at temperatures of 20 deg C and 60 deg C, showing stability at these temperatures. (author)

  7. Value determination of ZrO2 in-house reference material (RM) candidate

    International Nuclear Information System (INIS)

    The value determination of zirconium oxide in-house reference materials (RM) candidate has been done by referring to ISO:35-2006 standard. The raw material of RM was 4 kg of ZrO2, Merck, that was dried at 90°C for 2×6 hours in a closed room. The samples were crushed with stainless steel (SS) pestle to pass ≤ 200 mesh sieve, homogenized in a homogenizer for 3×6 hours to obtain the powdered, dried and homogenous samples. The gravimetric method was performed to test the moisture content, while XRF and AAS methods were used to test the homogeneity and stability of samples candidates. Reference material (RM) candidates of ZrO2 powder were put into polyethylene bottles, each weighing 100 g. Samples were distributed to 10 testing laboratories that have been accredited for testing the composition of the oxide contents and loss of ignition (LOI) using variety of analytical methods that have been validated such as AAS, XRF, NAA, and UV-Vis. The testing results of oxide content and loss of ignition parameters from various laboratories were analyzed using statistical methods. The testing data of oxide concentration in zirconium oxide RM candidates obtained from various laboratories were ZrO2: 97.7334 ± 0.0016%, HfO2: 1.7329 ± 0.0024%, SiO2: 30.1224 ± 0.0053%, Al2O3: 0.0245 ± 0.0015%, TiO2: 0.0153 ± 0.0006%, Fe2O3: 0.0068 ± 0.0005%, CdO: 3.1798 ± 0.00006 ppm, and the LOI results was = 0.0217 ± 0.00022%. (author)

  8. Development of a standard reference material for Cr(vi) in contaminated soil

    Science.gov (United States)

    Nagourney, S.J.; Wilson, S.A.; Buckley, B.; Kingston, H.M.S.; Yang, S.-Y.; Long, S.E.

    2008-01-01

    Over the last several decades, considerable contamination by hexavalent chromium has resulted from the land disposal of Chromite Ore Processing Residue (COPR). COPR contains a number of hexavalent chromium-bearing compounds that were produced in high temperature industrial processes. Concern over the carcinogenic potential of this chromium species, and its environmental mobility, has resulted in efforts to remediate these waste sites. To provide support to analytical measurements of hexavalent chromium, a candidate National Institute of Standards and Technology (NIST) Standard Reference Material?? (SRM 2701), having a hexavalent chromium content of approximately 500 mg kg -1, has been developed using material collected from a waste site in Hudson County, New Jersey, USA. The collection, processing, preparation and preliminary physico-chemical characterization of the material are discussed. A two-phase multi-laboratory testing study was carried out to provide data on material homogeneity and to assess the stability of the material over the duration of the study. The study was designed to incorporate several United States Environmental Protection Agency (USEPA) determinative methods for hexavalent chromium, including Method 6800 which is based on speciated isotope dilution mass spectrometry (SIDMS), an approach which can account for chromium species inter-conversion during the extraction and measurement sequence. This journal is ?? The Royal Society of Chemistry 2008.

  9. TOGAF 9 certified study guide

    CERN Document Server

    Group, The Open

    2010-01-01

    The TOGAF 9 certification program is a knowledge-based certification program. It has two levels, leading to certification for TOGAF 9 Foundation and TOGAF 9 Certified, respectively. The purpose of certification to TOGAF 9 Certified is to provide validation that, in addition to the knowledge and comprehension of TOGAF 9 Foundation level, the Candidate is able to analyze and apply this knowledge. The learning objectives at this level therefore focus on application and analysis in addition to knowledge and comprehension.This Study Guide supports students in preparation for the TOGAF 9 Part 2 Exam

  10. Noble metals as permanent chemical modifiers for the determination of mercury in environmental reference materials using solid sampling graphite furnace atomic absorption spectrometry and calibration against aqueous standards

    Science.gov (United States)

    da Silva, Alessandra Furtado; Welz, Bernhard; Curtius, Adilson J.

    2002-12-01

    Iridium, palladium, rhodium and ruthenium, thermally deposited on the platform, were investigated as permanent modifiers for the determination of mercury in ash, sludge, marine and river sediment reference materials, ground to a particle size of 50 μm, using solid sampling graphite furnace atomic absorption spectrometry. A total mass of 250 μg of each modifier was applied using 25 injections of 20 μl of modifier solution (500 mg l -1), and executing a temperature program for modifier conditioning after each injection. The performance of palladium was found to be most consistent, taking the characteristic mass as the major criterion, resulting in an excellent correlation between the measured integrated absorbance values and the certified mercury contents. Mercury was found to be lost in part from aqueous solutions during the drying stage in the presence of all the investigated permanent modifiers, as well as in the presence of the palladium and magnesium nitrates modifier added in solution. A loss-free determination of mercury in aqueous solutions could be reached only after the addition of potassium permanganate, which finally made possible the use of aqueous standards for the direct analysis of solid samples. A characteristic mass of 55-60 pg Hg was obtained for the solid samples, using Pd as a permanent modifier, and also in aqueous solutions after the addition of permanganate. The results obtained for mercury in ash, sludge and sediment reference materials, using direct solid sapling and calibration against aqueous standards, as well as the detection limit of 0.2 mg kg -1 were satisfactory for a routine procedure.

  11. Noble metals as permanent chemical modifiers for the determination of mercury in environmental reference materials using solid sampling graphite furnace atomic absorption spectrometry and calibration against aqueous standards

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Alessandra Furtado da; Welz, Bernhard; Curtius, Adilson J

    2002-12-02

    Iridium, palladium, rhodium and ruthenium, thermally deposited on the platform, were investigated as permanent modifiers for the determination of mercury in ash, sludge, marine and river sediment reference materials, ground to a particle size of 50 {mu}m, using solid sampling graphite furnace atomic absorption spectrometry. A total mass of 250 {mu}g of each modifier was applied using 25 injections of 20 {mu}l of modifier solution (500 mg l{sup -1}), and executing a temperature program for modifier conditioning after each injection. The performance of palladium was found to be most consistent, taking the characteristic mass as the major criterion, resulting in an excellent correlation between the measured integrated absorbance values and the certified mercury contents. Mercury was found to be lost in part from aqueous solutions during the drying stage in the presence of all the investigated permanent modifiers, as well as in the presence of the palladium and magnesium nitrates modifier added in solution. A loss-free determination of mercury in aqueous solutions could be reached only after the addition of potassium permanganate, which finally made possible the use of aqueous standards for the direct analysis of solid samples. A characteristic mass of 55-60 pg Hg was obtained for the solid samples, using Pd as a permanent modifier, and also in aqueous solutions after the addition of permanganate. The results obtained for mercury in ash, sludge and sediment reference materials, using direct solid sapling and calibration against aqueous standards, as well as the detection limit of 0.2 mg kg{sup -1} were satisfactory for a routine procedure.

  12. Soil contamination in plant samples and in botanical reference materials. Signature, quantification and consequences

    International Nuclear Information System (INIS)

    Individual samples of several sets of plants (lichens, tobacco, spruce needles, grass, botanical reference materials) show highly significant correlations of Al, Fe, Hf, La, Na, Th, Ti and V with Sc. These correlations result from the terrigenous part of aerosols deposited on and measured together with the plants. The composition of this contamination is almost uniform among the different plant sets and can be approximated by the composition of the upper continental crust. The mass of the terrigenous material ranges from 100 mg/g plant. Its presence is expected to lead to concentrations of the above and of other elements that deviate substantially from those of plants without contamination. This is proved by the comparison of two sets of spruce needles, one of which was measured without and the other after removal of the aerosol. (author)

  13. 1984 EC enquiry into the needs for nuclear reference materials (Z>89)

    International Nuclear Information System (INIS)

    For years now, experts in the nuclear field have expressed and pointed out the widespread need for Nuclear Reference Materials (NRMs) in the whole of the nuclear fuel cycle. NRMs were defined as actinides with well-characterized chemical, isotopic and/or physical properties for use as a common base for the calibration of instruments and checking of analytical methods. Since nuclear energy from fission reactors is an increasing contributor to the electricity generating capacity in the EC, there is an equivalent demand for accurate analytical measurements in the various stages of the fuel cycle and in associated fields such as: commercial transactions, production control, nuclear material accounting (safeguards), waste disposal, environmental and health physics, research and development. An essential element for improving analyses and measurements is the availability and use of the appropriate NRMs

  14. Toward New High Temperature Reference Materials for Calorimetry and Thermal Analysis

    Directory of Open Access Journals (Sweden)

    Razouk R.

    2014-01-01

    Full Text Available The French National Metrology Laboratory LNE-LCM has developed a high temperature reference facility for accurate measurements of the specific heat capacity and of the enthalpy of fusion of materials over the temperature range [23 °C, 1000 °C]. The metrological approach was to modify a commercial Calvet calorimeter in order to lower the uncertainty of measurement and to insure the metrological traceability of the measurements to the SI units, in particular by designing a new calibration system. The enthalpies of fusion of pure metals (indium, tin and silver and of a binary alloy Ag-28Cu have been measured. The results obtained on the three pure metallic materials are in very good agreement with data obtained by other National Metrology Institutes (NMIs using adiabatic calorimetry.

  15. A GUPIX-based approach to interpreting the PIXE-plus-XRF spectra from the Mars Exploration rovers: II geochemical reference materials

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, J.L., E-mail: icampbel@uoguelph.c [Guelph-Waterloo Physics Institute, University of Guelph, Guelph, Ontario, N1G 2W1 (Canada); McDonald, A.M. [Department of Earth Sciences, Laurentian University, Sudbury, Ontario, P3E 2E6 (Canada); Perrett, G.M. [Guelph-Waterloo Physics Institute, University of Guelph, Guelph, Ontario, N1G 2W1 (Canada); Taylor, S.M. [Department of Atmospheric and Oceanic Sciences, McGill University, Montreal, Quebec, H3A 2T5 (Canada)

    2011-01-01

    A detailed examination of the original calibration data for the laboratory version of the Mars Exploration Rover alpha particle X-ray spectrometer is undertaken to ascertain if the results from a suite of certified geochemical reference materials (GRMs) agree with the APXS calibration based upon homogeneous standards which was established in the previous paper. Various discrepancies, some of them large, are observed for specific elements in specific rock types, and it is argued on the basis of X-ray diffraction analyses of the GRMS that these are caused by the mineral phase structure of the rocks. Elements present in accessory mineral phases can be subject to very large errors, necessitating caution in interpretation of trace element results from the APXS. Some of the discrepancies can be dealt with by developing sub-calibrations, each of which is 'tuned' to a specific rock type. This approach has the potential to provide more accurate APXS analysis of unknown rocks than a calibration scheme based upon a simple averaging over many rock types within a GRM suite, or over a mix of rock and homogeneous standards. It also has the potential to measure the content of mineralogically bound water provided that a means of determining the distance from sample to detector is available.

  16. Organomercury determination in biological reference materials: application to a study on mercury speciation in marine mammals off the Faröe Islands.

    Science.gov (United States)

    Schintu, M; Jean-Caurant, F; Amiard, J C

    1992-08-01

    The potential use of graphite furnace atomic absorption spectrometry (GF-AAS) for the organic mercury determination in marine biological tissues was evaluated. Following its isolation by acid extraction in toluene, organic mercury was recovered in aqueous thiosulfate and measured by GF-AAS. The detection limit was 0.01 microgram Hg/g (as methyl mercury). Analyses were conducted on three reference standard materials certified for their methyl mercury content, DOLT-1, DORM-1, and TORT-1, provided by the National Research Council of Canada. The method resulted in very good recovery and reproducibility, indicating that GF-AAS can provide results comparable to those obtained by using more expensive and time consuming analytical techniques. The method was applied to the analysis of liver tissues of pilot whale specimens (Globicephala melas) from the drive fishery of the Faröe Islands (northeast Atlantic). The results provided useful information on the proportion of different mercury forms in the liver of these marine mammals.

  17. CEH Certified Ethical Hacker Study Guide

    CERN Document Server

    Graves, Kimberly

    2010-01-01

    Prepare for the new version of CEH certification with this advanced guide. Once you learn the thought processes of unethical hackers, you can figure out how to secure your computer systems to defend against them. That's the philosophy behind ethical hacking, and it's a growing field. Prepare for certification in this important area with this advanced study guide that covers all exam objectives for the challenging CEH Certified Ethical Hackers exam. The book provides full coverage of exam topics, real-world examples, and a CD with additional materials for extra review and practice.:; Covers eth

  18. Utilizing a reference material for assessing absolute tumor mechanical properties in modality independent elastography

    Science.gov (United States)

    Kim, Dong Kyu; Weis, Jared A.; Yankeelov, Thomas E.; Miga, Michael I.

    2014-03-01

    There is currently no reliable method for early characterization of breast cancer response to neoadjuvant chemotherapy (NAC) [1,2]. Given that disruption of normal structural architecture occurs in cancer-bearing tissue, we hypothesize that further structural changes occur in response to NAC. Consequently, we are investigating the use of modalityindependent elastography (MIE) [3-8] as a method for monitoring mechanical integrity to predict long term outcomes in NAC. Recently, we have utilized a Demons non-rigid image registration method that allows 3D elasticity reconstruction in abnormal tissue geometries, making it particularly amenable to the evaluation of breast cancer mechanical properties. While past work has reflected relative elasticity contrast ratios [3], this study improves upon that work by utilizing a known stiffness reference material within the reconstruction framework such that a stiffness map becomes an absolute measure. To test, a polyvinyl alcohol (PVA) cryogel phantom and a silicone rubber mock mouse tumor phantom were constructed with varying mechanical stiffness. Results showed that an absolute measure of stiffness could be obtained based on a reference value. This reference technique demonstrates the ability to generate accurate measurements of absolute stiffness to characterize response to NAC. These results support that `referenced MIE' has the potential to reliably differentiate absolute tumor stiffness with significant contrast from that of surrounding tissue. The use of referenced MIE to obtain absolute quantification of biomarkers is also translatable across length scales such that the characterization method is mechanics-consistent at the small animal and human application.

  19. 76 FR 80741 - TRICARE: Certified Mental Health Counselors

    Science.gov (United States)

    2011-12-27

    .... 13132. List of Subjects in 32 CFR Part 199 Claims, Dental health, Health care, Health insurance... referred for therapy by a physician; and (ii) A physician is providing ongoing oversight and supervision of the therapy being provided; and (iii) The mental health counselor certifies on each claim...

  20. Periodic reference tracking control approach for smart material actuators with complex hysteretic characteristics

    Science.gov (United States)

    Sun, Zhiyong; Hao, Lina; Song, Bo; Yang, Ruiguo; Cao, Ruimin; Cheng, Yu

    2016-10-01

    Micro/nano positioning technologies have been attractive for decades for their various applications in both industrial and scientific fields. The actuators employed in these technologies are typically smart material actuators, which possess inherent hysteresis that may cause systems behave unexpectedly. Periodic reference tracking capability is fundamental for apparatuses such as scanning probe microscope, which employs smart material actuators to generate periodic scanning motion. However, traditional controller such as PID method cannot guarantee accurate fast periodic scanning motion. To tackle this problem and to conduct practical implementation in digital devices, this paper proposes a novel control method named discrete extended unparallel Prandtl-Ishlinskii model based internal model (d-EUPI-IM) control approach. To tackle modeling uncertainties, the robust d-EUPI-IM control approach is investigated, and the associated sufficient stabilizing conditions are derived. The advantages of the proposed controller are: it is designed and represented in discrete form, thus practical for digital devices implementation; the extended unparallel Prandtl-Ishlinskii model can precisely represent forward/inverse complex hysteretic characteristics, thus can reduce modeling uncertainties and benefits controllers design; in addition, the internal model principle based control module can be utilized as a natural oscillator for tackling periodic references tracking problem. The proposed controller was verified through comparative experiments on a piezoelectric actuator platform, and convincing results have been achieved.

  1. Soot Reference Materials for instrument calibration and intercomparisons: a workshop summary with recommendations

    Directory of Open Access Journals (Sweden)

    D. Baumgardner

    2012-03-01

    Full Text Available Soot, which is produced from biomass burning and the incomplete combustion of fossil and biomass fuels, has been linked to regional and global climate change and to negative health problems. Scientists measure soot using a variety of methods in order to quantify source emissions and understand its atmospheric chemistry, reactivity under emission conditions, interaction with solar radiation, influence on clouds, and health impacts. A major obstacle currently limiting progress is the absence of established standards or reference materials for calibrating the many instruments used to measure the various properties of soot.

    The current state of availability and practicability of soot standard reference materials (SRMs was reviewed by a group of 50 international experts during a workshop in June of 2011. The workshop was convened to summarize the current knowledge on soot measurement techniques, identify the measurement uncertainties and limitations related to the lack of SRMs, and identify attributes of SRMs that, if developed, would reduce measurement uncertainties. The workshop established that suitable SRMs are available for calibrating some, but not all, measurement methods. The community of single-particle sootphotometer (SP2 users identified a suitable SRM, fullerene soot, but users of instruments that measure light absorption by soot collected on filters did not. Similarly, those who use thermal optical analysis (TOA to analyze the organic and elemental carbon components of soot were not satisfied with current SRMs. The workshop produced recommendations for the development of new SRMs that would be suitable for the different soot measurement methods.

  2. Extensive sequencing of seven human genomes to characterize benchmark reference materials.

    Science.gov (United States)

    Zook, Justin M; Catoe, David; McDaniel, Jennifer; Vang, Lindsay; Spies, Noah; Sidow, Arend; Weng, Ziming; Liu, Yuling; Mason, Christopher E; Alexander, Noah; Henaff, Elizabeth; McIntyre, Alexa B R; Chandramohan, Dhruva; Chen, Feng; Jaeger, Erich; Moshrefi, Ali; Pham, Khoa; Stedman, William; Liang, Tiffany; Saghbini, Michael; Dzakula, Zeljko; Hastie, Alex; Cao, Han; Deikus, Gintaras; Schadt, Eric; Sebra, Robert; Bashir, Ali; Truty, Rebecca M; Chang, Christopher C; Gulbahce, Natali; Zhao, Keyan; Ghosh, Srinka; Hyland, Fiona; Fu, Yutao; Chaisson, Mark; Xiao, Chunlin; Trow, Jonathan; Sherry, Stephen T; Zaranek, Alexander W; Ball, Madeleine; Bobe, Jason; Estep, Preston; Church, George M; Marks, Patrick; Kyriazopoulou-Panagiotopoulou, Sofia; Zheng, Grace X Y; Schnall-Levin, Michael; Ordonez, Heather S; Mudivarti, Patrice A; Giorda, Kristina; Sheng, Ying; Rypdal, Karoline Bjarnesdatter; Salit, Marc

    2016-06-07

    The Genome in a Bottle Consortium, hosted by the National Institute of Standards and Technology (NIST) is creating reference materials and data for human genome sequencing, as well as methods for genome comparison and benchmarking. Here, we describe a large, diverse set of sequencing data for seven human genomes; five are current or candidate NIST Reference Materials. The pilot genome, NA12878, has been released as NIST RM 8398. We also describe data from two Personal Genome Project trios, one of Ashkenazim Jewish ancestry and one of Chinese ancestry. The data come from 12 technologies: BioNano Genomics, Complete Genomics paired-end and LFR, Ion Proton exome, Oxford Nanopore, Pacific Biosciences, SOLiD, 10X Genomics GemCode WGS, and Illumina exome and WGS paired-end, mate-pair, and synthetic long reads. Cell lines, DNA, and data from these individuals are publicly available. Therefore, we expect these data to be useful for revealing novel information about the human genome and improving sequencing technologies, SNP, indel, and structural variant calling, and de novo assembly.

  3. Determination of plutonium isotopes in seawater reference materials using isotope-dilution ICP-MS.

    Science.gov (United States)

    Zheng, Jian; Yamada, Masatoshi

    2012-09-01

    We analyzed the activities of (239)Pu, (240)Pu, (239+240)Pu, (241)Pu, the ratio of number of atoms (atom ratio) for (240)Pu/(239)Pu, and the activity ratio of (241)Pu/(239+240)Pu in seawater reference materials, IAEA-443 and IAEA-381, using a highly sensitive isotope dilution sector field inductively coupled plasma mass spectrometry method. With a mean chemical yield of 65% determined with (242)Pu as a tracer, we found that the experimentally established values in IAEA-443 for (239)Pu, (240)Pu, (241)Pu and (239+240)Pu activities are almost the same as those in IAEA-381. Regarding the (239+240)Pu activity, we provided the most precise and accurate result among the twelve laboratories, which participated in the interlaboratory comparison. In addition, for the (240)Pu/(239)Pu atom ratio, our results for IAEA-381 (0.2315±0.0008) and IAEA-443 (0.2325±0.0008) are in good agreement with the IAEA information value (0.229±0.006), but have much smaller uncertainty. Since the new seawater reference material, IAEA-443, is commercially available, it can be used not only for method validation for seawater plutonium isotope ratio and activity analysis, but also for more general use as a plutonium isotope standard for mass discrimination correction for other environmental samples.

  4. Certifiable Java for Embedded Systems

    DEFF Research Database (Denmark)

    Schoeberl, Martin; Hansen, René Rydhof; Ravn, Anders P.;

    2014-01-01

    The Certifiable Java for Embedded Systems (CJ4ES) project aimed to develop a prototype development environment and platform for safety-critical software for embedded applications. There are three core constituents: A profile of the Java programming language that is tailored for safety...

  5. Nuclear measurements and reference materials annual progress report, january - december 1988

    International Nuclear Information System (INIS)

    The 1988 progress report of the Central Bureau for Nuclear Measurements (CBNM) is presented. The major changes in the role and orientation of the Joint Research Center, of which CBNM is an institute, are included. The main tasks of CBNM, which involve the program on Nuclear Measurements and Reference Materials, are given. Technical activities concerning the GELINA electron beam and Van de Graaff accelerators are reported. The study of transition radiation at linear electron accelerators, and the development of isotope dilution mass spectrometry, for trace analysis and isotope abundance measurements in iron and gallium, are summarized. The scientific and technical support to the commission, work for third parties, and contribution to conferences are presented

  6. The IAEA programme and perspectives for environmental radionuclide monitoring and preparation of reference materials

    International Nuclear Information System (INIS)

    For more than thirty years, the laboratories of the International Atomic Energy Agency have been involved in the monitoring of environmental radioactivity and in the world-wide provision of reference materials for radionuclides in environmental matrices. The occurrence of hot particles in selected sites and their morphological, structural, chemical and radiochemical characteristics have to be better investigated in order to identify possible correlations with the contaminating event and to assess the associated radiological risks. Research on radionuclides in the environment will also be extended to the measurement and compilation of data on the contaminants introduced by non-nuclear industrial activities and agrochemical treatments. In response to the world-wide trend towards increased reliability, comparability and traceability of chemical and radiochemical measurements, The IAEA will revise, develop and document a set of reference analytical procedures for naturally occurring radionuclides, which will supplement the current revision of procedures for anthropogenic radionuclides. The IAEA will enhance its support provided to the laboratories in the Member States for the implementation of a quality system and to achieve traceability of their radiometric measurements. Furthermore the IAEA will continue to provide training and maintain comparability and reliability of environmental radiochemical measurements by organizing proficiency tests and interlaboratory comparisons. These tests and exercises will also be used by the IAEA to monitor and evaluate the capability and preparedness of its ALMERA (Analytical Laboratories for Measuring Environmental Radioactivity) Network

  7. Using environmental reference materials for quality assurance in spanish radiochemical laboratories

    International Nuclear Information System (INIS)

    In order to achieve international acceptance of results, laboratories must be in a position to demonstrate that their results are reliable and traceable to SI units of measurement. Laboratories can provide objective evidence of their performance through participation in external quality assessment schemes sometimes referred to as proficiency tests (PT). To achieve this objective for environmental radioactivity laboratories in Spain, CSN, in collaboration with CIEMAT, has organised periodical intercomparison exercises to provide these laboratories with the means to assess the quality of their results. In order to implement the ISO/IUPAC/AOAC Harmonised Protocol for the Proficiency Testing of Analytical Laboratories, CIEMAT has been collaborating with the IAEA-AQCS during the last two exercises and has used IAEA reference materials as test samples. The first PT was organised using the IAEA-SED-1 which is a lake sediment containing K40, Ra226, Ac228, Cs137, Sr90, and Pu-(239+240), while the second PT used IAEA-Soil- 6 for the same set of radionuclides. This paper presents the results reported for the second test as well as a comparison of the participants' performance in both tests. The application of this Harmonised Protocol has provided an objective assessment of the performance of the laboratories, enabling them to evaluate and make appropriate modifications to their procedures

  8. Soot reference materials for instrument calibration and intercomparisons: a workshop summary with recommendations

    Directory of Open Access Journals (Sweden)

    D. Baumgardner

    2012-08-01

    Full Text Available Soot, which is produced from biomass burning and the incomplete combustion of fossil and biomass fuels, has been linked to regional and global climate change and to negative health problems. Scientists measure the properties of soot using a variety of methods in order to quantify source emissions and understand its atmospheric chemistry, reactivity under emission conditions, interaction with solar radiation, influence on clouds, and health impacts. A major obstacle currently limiting progress is the absence of established standards or reference materials for calibrating the many instruments used to measure the various properties of soot.

    The current state of availability and practicability of soot standard reference materials (SRMs was reviewed by a group of 50 international experts during a workshop in June of 2011. The workshop was convened to summarize the current knowledge on soot measurement techniques, identify the measurement uncertainties and limitations related to the lack of soot SRMs, and identify attributes of SRMs that, if developed, would reduce measurement uncertainties. The workshop established that suitable SRMs are available for calibrating some, but not all, measurement methods. The community of users of the single-particle soot-photometer (SP2, an instrument using laser-induced incandescence, identified a suitable SRM, fullerene soot, but users of instruments that measure light absorption by soot collected on filters did not. Similarly, those who use thermal optical analysis (TOA to analyze the organic and elemental carbon components of soot were not satisfied with current SRMs. The workshop, and subsequent, interactive discussions, produced a number of recommendations for the development of new SRMs, and their implementation, that would be suitable for the different soot measurement methods.

  9. Feasibility study on production of a matrix reference material for cyanobacterial toxins.

    Science.gov (United States)

    Hollingdale, Christie; Thomas, Krista; Lewis, Nancy; Békri, Khalida; McCarron, Pearse; Quilliam, Michael A

    2015-07-01

    The worldwide increase in cyanobacterial contamination of freshwater lakes and rivers is of great concern as many cyanobacteria produce potent hepatotoxins and neurotoxins (cyanotoxins). Such toxins pose a threat to aquatic ecosystems, livestock, and drinking water supplies. In addition, dietary supplements prepared from cyanobacteria can pose a risk to consumers if they contain toxins. Analytical monitoring for toxins in the environment and in consumer products is essential for the protection of public health. Reference materials (RMs) are an essential tool for the development and validation of analytical methods and are necessary for ongoing quality control of monitoring operations. Since the availability of appropriate RMs for cyanotoxins has been very limited, the present study was undertaken to examine the feasibility of producing a cyanobacterial matrix RM containing various cyanotoxins. The first step was large-scale culturing of various cyanobacterial cultures that produce anatoxins, microcystins, and cylindrospermopsins. After harvesting, the biomass was lyophilized, blended, homogenized, milled, and bottled. The moisture content and physical characteristics were assessed in order to evaluate the effectiveness of the production process. Toxin levels were measured by liquid chromatography with tandem mass spectrometry and ultraviolet detection. The reference material was found to be homogeneous for toxin content. Stability studies showed no significant degradation of target toxins over a period of 310 days at temperatures up to +40 °C except for the anatoxin-a, which showed some degradation at +40 °C. These results show that a fit-for-purpose matrix RM for cyanotoxins can be prepared using the processes and techniques applied in this work. PMID:25929442

  10. Estimation of uncertainty of a reference material for proficiency testing for the determination of total mercury in fish in nature

    International Nuclear Information System (INIS)

    We provide an uncertainty estimates for homogeneity and stability studies of reference material used in proficiency test for determination of total mercury in fish fresh muscle tissue. Stability was estimated by linear regression and homogeneity by ANOVA. The results indicate that the reference material is both homogeneous and chemically stable over the short term. Total mercury concentration of the muscle tissue, with expanded uncertainty, was 0.294 ± 0.089 μg g−1

  11. 7 CFR 983.7 - Certified pistachios.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Certified pistachios. 983.7 Section 983.7 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE PISTACHIOS GROWN IN CALIFORNIA, ARIZONA, AND NEW MEXICO Definitions § 983.7 Certified pistachios. Certified pistachios are those that...

  12. 1 CFR 18.5 - Certified copies.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Certified copies. 18.5 Section 18.5 General... DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.5 Certified copies. The certified copies or duplicate originals of each document must be submitted with the original. Each copy or...

  13. 7 CFR 1221.4 - Certified organization.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Certified organization. 1221.4 Section 1221.4 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... organization. Certified organization means any organization that has been certified by the Secretary...

  14. 7 CFR 1280.103 - Certified organization.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Certified organization. 1280.103 Section 1280.103 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... organization. Certified organization means any organization which has been certified by the Secretary...

  15. Twenty five years of reference material activity at Agriculture and Agri-Food Canada.

    Science.gov (United States)

    Ihnat, M

    2001-06-01

    In the mid 1970s, the available RMs, notably Bowen's Kale and Orchard Leaves and Bovine liver from National Bureau of Standards (NBS), although of great benefit, were overwhelmingly insufficiently representative, in respect of matrix and elemental composition, of the wide range of natural products submitted for analysis and in worldwide commerce. To provide additional coverage, an RM development project was initiated with input from cooperating analysts leading to an Agriculture and Agri-Food Canada/National Institute of Standards and Technology (NIST) cooperative venture and development of a total of 12 different agricultural/food RMs. With a total of 303 concentration values for 34 elements and a wide range of matrix components such as ash, silica, protein, fat, carbohydrate and fiber, these RMs significantly augment the world repertoire of biological control materials. A final material under consideration is a highly reliable, discrete, synthetic RM for quality control and calibration. This paper summarizes the research and developmental activities undertaken during the past quarter of a century related to RM development at Agriculture and Agri-Food Canada and includes a short historical background, conceptual considerations, preparation, physical characterization, homogeneity estimation, chemical characterization, calculation of recommended reference values and associated uncertainties, methodology development and application, and performance of inorganic analytical methods in a multielement, multilaboratory, collaborative characterization campaign. PMID:11451252

  16. Development of a candidate reference material for adventitious virus detection in vaccine and biologicals manufacturing by deep sequencing

    OpenAIRE

    Edward T Mee; Preston, Mark D.; Minor, Philip D.; ,; Huang, Xuening; Nguyen, Jenny; Wall, David; Hargrove, Stacey; Fu, Thomas; Xu, George; Li, Li; Cote, Colette; Delwart, Eric; Li, Linlin; Hewlett, Indira

    2016-01-01

    Background Unbiased deep sequencing offers the potential for improved adventitious virus screening in vaccines and biotherapeutics. Successful implementation of such assays will require appropriate control materials to confirm assay performance and sensitivity. Methods A common reference material containing 25 target viruses was produced and 16 laboratories were invited to process it using their preferred adventitious virus detection assay. Results Fifteen laboratories returned results, obtai...

  17. NIST bullet signature measurement system for RM (Reference Material) 8240 standard bullets.

    Science.gov (United States)

    Ma, Li; Song, John; Whitenton, Eric; Zheng, Alan; Vorburger, Theodore; Zhou, Jack

    2004-07-01

    A bullet signature measurement system based on a stylus instrument was developed at the National Institute of Standards and Technology (NIST) for the signature measurements of NIST RM (Reference Material) 8240 standard bullets. The standard bullets are developed as a reference standard for bullet signature measurements and are aimed to support the recently established National Integrated Ballistics Information Network (NIBIN) by the Bureau of Alcohol, Tobacco and Firearms (ATF) and the Federal Bureau of Investigation (FBI). The RM bullets are designed as both a virtual and a physical bullet signature standard. The virtual standard is a set of six digitized bullet signatures originally profiled from six master bullets fired at ATF and FBI using six different guns. By using the virtual signature standard to control the tool path on a numerically controlled diamond turning machine at NIST, 40 RM bullets were produced. In this paper, a comparison parameter and an algorithm using auto-and cross-correlation functions are described for qualifying the bullet signature differences between the RM bullets and the virtual bullet signature standard. When two compared signatures are exactly the same (point by point), their cross-correlation function (CCF) value will be equal to 100%. The measurement system setup, measurement program, and initial measurement results are discussed. Initial measurement results for the 40 standard bullets, each measured at six land impressions, show that the CCF values for the 240 signature measurements are higher than 95%, with most of them even higher than 99%. These results demonstrate the high reproducibility for both the manufacturing process and the measurement system for the NIST RM 8240 standard bullets. PMID:15317178

  18. New Organic Stable Isotope Reference Materials for Distribution through the USGS and the IAEA

    Science.gov (United States)

    Schimmelmann, Arndt; Qi, Haiping

    2014-05-01

    The widespread adoption of relative stable isotope-ratio measurements in organic matter by diverse scientific disciplines is at odds with the dearth of international organic stable isotopic reference materials (RMs). Only two of the few carbon (C) and nitrogen (N) organic RMs, namely L-glutamic acids USGS40 and USGS41 [1], both available from the U.S. Geological Survey (USGS) and the International Atomic Energy Agency (IAEA), provide an isotopically contrasting pair of organic RMs to enable essential 2-point calibrations for δ-scale normalization [2, 3]. The supply of hydrogen (H) organic RMs is even more limited. Numerous stable isotope laboratories have resorted to questionable practices, for example by using 'CO2, N2, and H2 reference gas pulses' for isotopic calibrations, which violates the principle of identical treatment of sample and standard (i.e., organic unknowns should be calibrated directly against chemically similar organic RMs) [4], or by using only 1 anchor instead of 2 for scale calibration. The absence of international organic RMs frequently serves as an excuse for indefensible calibrations. In 2011, the U.S. National Science Foundation (NSF) funded an initiative of 10 laboratories from 7 countries to jointly develop much needed new organic RMs for future distribution by the USGS and the IAEA. The selection of targeted RMs attempts to cover various common compound classes of broad technical and scientific interest. We had to accept compromises to approach the ideal of high chemical stability, lack of toxicity, and low price of raw materials. Hazardous gases and flammable liquids were avoided in order to facilitate international shipping of future RMs. With the exception of polyethylene and vacuum pump oil, all organic RMs are individual, chemically-pure substances, which can be used for compound-specific isotopic measurements in conjunction with liquid and gas chromatographic interfaces. The compounds listed below are under isotopic calibration by

  19. Compatibility of OMRI certified surfactants with three entomopathogenic fungi

    Science.gov (United States)

    The Organic Materials Review Institute (OMRI) is a nonprofit organization providing an independent review of products intended for use in organic production systems to certify compliance with U.S. National organic standards. Since all adjuvants to be used in organic agriculture production are requir...

  20. Provisional Assessment of Candidate High-Temperature Thermal Conductivity Reference Materials in the EMRP “Thermo” Project

    OpenAIRE

    Wu, J.; Morrell, R; T. Fry; Gnaniah, S.; Gohil, D.; Dawson, A.; Hameury, J.; Koenen, Alain; Hammerschmidt, U.; Turzó-András, E.; Strnad, R.; Blahut, A.

    2015-01-01

    This article describes the provisional assessment of a short list of four candidate high-temperature thermal conductivity reference materials in a European research project, “Thermo.” These four candidate materials are low-density calcium silicate, amorphous silica, high-density calcium silicate, and exfoliated vermiculite. Based on initial tests on material composition and microstructure changes, dimensional stability, mechanical stability, chemical stability and uniformity, the best two can...

  1. Retrospective Analysis of NIST Standard Reference Material 1450, Fibrous Glass Board, for Thermal Insulation Measurements.

    Science.gov (United States)

    Zarr, Robert R; Heckert, N Alan; Leigh, Stefan D

    2014-01-01

    Thermal conductivity data acquired previously for the establishment of Standard Reference Material (SRM) 1450, Fibrous Glass Board, as well as subsequent renewals 1450a, 1450b, 1450c, and 1450d, are re-analyzed collectively and as individual data sets. Additional data sets for proto-1450 material lots are also included in the analysis. The data cover 36 years of activity by the National Institute of Standards and Technology (NIST) in developing and providing thermal insulation SRMs, specifically high-density molded fibrous-glass board, to the public. Collectively, the data sets cover two nominal thicknesses of 13 mm and 25 mm, bulk densities from 60 kg·m(-3) to 180 kg·m(-3), and mean temperatures from 100 K to 340 K. The analysis repetitively fits six models to the individual data sets. The most general form of the nested set of multilinear models used is given in the following equation: [Formula: see text]where λ(ρ,T) is the predicted thermal conductivity (W·m(-1)·K(-1)), ρ is the bulk density (kg·m(-3)), T is the mean temperature (K) and ai (for i = 1, 2, … 6) are the regression coefficients. The least squares fit results for each model across all data sets are analyzed using both graphical and analytic techniques. The prevailing generic model for the majority of data sets is the bilinear model in ρ and T. [Formula: see text] One data set supports the inclusion of a cubic temperature term and two data sets with low-temperature data support the inclusion of an exponential term in T to improve the model predictions. Physical interpretations of the model function terms are described. Recommendations for future renewals of SRM 1450 are provided. An Addendum provides historical background on the origin of this SRM and the influence of the SRM on external measurement programs.

  2. Physical properties of oil-SPM aggregates : experiments with NIST standard reference material 1941b

    Energy Technology Data Exchange (ETDEWEB)

    Khelifa, A.; Brown, C.E. [Environment Canada, Ottawa, ON (Canada). Emergencies Science and Technology Division, Science and Technology Branch, Environmental Science and Technology Centre; Chun, M.; Eubank, J.L.E. [Waterloo Univ., ON (Canada). Nanotechnology Engineering

    2008-07-01

    Oil spilled in water disperses by a natural process in which suspended particulate matter (SPM) combines with oil droplets to form Oil-SPM aggregates (OSA). This paper presented a newly developed experimental procedure to measure the physical properties of OSAs, including size, settling velocity and effective density. A laboratory setup was created to examine the formation of OSAs in which the sediment Standard Reference Material 1941b was mixed with Arabian Medium and South Louisiana crude oils, and Corexit 9500 chemical dispersants at various concentrations. The study revealed that the hypothesis stating that OSAs are neutrally buoyant and do not settle to the seafloor is not valid. The OSAs appeared to behave as sediment flocs commonly observed in coastal waters. It was concluded that from an oil spill response perspective, the use of chemical dispersant in coaster waters rich in SPM could be problematic since it may enhance oil sedimentation and contaminate the seafloor. However, further research is needed to evaluate the effects of other key factors controlling the fate of OSAs that were not investigated in this study. These include the effect of mixing energy and the settling process of natural flocs. 29 refs., 1 tab., 10 figs.

  3. Effective density of Aquadag and fullerene soot black carbon reference materials used for SP2 calibration

    Directory of Open Access Journals (Sweden)

    M. Gysel

    2011-08-01

    Full Text Available The mass and effective density of black carbon (BC particles generated from aqueous suspensions of Aquadag and fullerene soot was measured and parametrized as a function of their mobility diameter. The measurements were made by two independent research groups by operating a differential mobility analyser (DMA in series with an aerosol particle mass analyser (APM or a Couette centrifugal particle mass analyser (CPMA. Consistent and reproducible results were found in this study for different production lots of Aquadag, indicating that the effective density of these particles is a stable quantity and largely unaffected by differences in aerosol generation procedures and suspension treatments. The effective density of fullerene soot particles from one production lot was also found to be stable and independent of suspension treatments. Some difference to previous literature data was observed for both Aquadag and fullerene soot at larger particle diameters. Knowledge of the exact relationship between mobility diameter and particle mass is of great importance, as DMAs are commonly used to size-select particles from BC reference materials for calibration of single particle soot photometers (SP2, which quantitatively detect the BC mass in single particles.

  4. Effective density of Aquadag and fullerene soot black carbon reference materials used for SP2 calibration

    Directory of Open Access Journals (Sweden)

    M. Gysel

    2011-12-01

    Full Text Available The mass and effective density of black carbon (BC particles generated from aqueous suspensions of Aquadag and fullerene soot was measured and parametrized as a function of their mobility diameter. The measurements were made by two independent research groups by operating a differential mobility analyser (DMA in series with an aerosol particle mass analyser (APM or a Couette centrifugal particle mass analyser (CPMA. Consistent and reproducible results were found in this study for different production lots of Aquadag, indicating that the effective density of these particles is a stable quantity and largely unaffected by differences in aerosol generation procedures and suspension treatments. The effective density of fullerene soot particles from one production lot was also found to be stable and independent of suspension treatments. Some differences to previous literature data were observed for both Aquadag and fullerene soot at larger particle diameters. Knowledge of the exact relationship between mobility diameter and particle mass is of great importance, as DMAs are commonly used to size-select particles from BC reference materials for calibration of single particle soot photometers (SP2, which quantitatively detect the BC mass in single particles.

  5. Results of 14C analysis on low-level reference materials

    International Nuclear Information System (INIS)

    An invitation from the University of Glasgow to participate in an international intercomparison of 14C analysis and the increased need for quality assurance for measurements performed at the Low-Level Laboratory by AECL's Environmental Technologies Branch (ETB), Chalk River Laboratories, prompted the initiation of this work. Standard 14C samples from the IAEA and from the ETB were analyzed and compared to their reference values. All analyses agreed well with reported values and confirmed that the ETB can reliably measure 14C between 50 and 500 Bq/kg C. Samples from the University of Glasgow, Scotland, were also analyzed and reported. The results of counting various CO2 blank materials (dry ice from a CO2-siphon and limestone) showed that the source of CO2 does not have an effect on background count rate or counter efficiency. The ETB's lower limit of detection (LLD) has been calculated to be 10 -20 Bq/kg C and the determination limit (LQ) for samples during the ETB's routine operations has been documented to be 44 Bq/kg C. (author)

  6. Certifiable Java for Embedded Systems

    DEFF Research Database (Denmark)

    Schoeberl, Martin; Dalsgaard, Andreas Engelbredt; Hansen, Rene Rydhof;

    2014-01-01

    The Certifiable Java for Embedded Systems (CJ4ES) project aimed to develop a prototype development environment and platform for safety-critical software for embedded applications. There are three core constituents: A profile of the Java programming language that is tailored for safety......-critical applications, a predictable Java processor built with FPGA technology, and an Eclipse based application development environment that binds the profile and the platform together and provides analyses that help to provide evidence that can be used as part of a safety case. This paper summarizes key contributions...

  7. Report of the consultants' meeting on traceability of IAEA-AQCS reference materials to SI-units

    International Nuclear Information System (INIS)

    The purpose of the meeting was to discuss the present Agency's Analytical Quality Control Services (AQCS) procedure for the characterization of reference materials and to identify necessary improvements or changes needed to fulfill the requirements on traceability and uncertainty related to the property value of IAEA reference materials. This publication contains a summary of the discussions held at the meeting as well as specific recommendations made by the consultants. It also contains draft reports of two previous meetings and individual papers presented by the consultants at the meeting. These reports and papers have been provided with abstracts and indexed separately

  8. Ten Reference Materials for Available Nutrients of Agricultural Soils%10个土壤有效态成分分析标准物质研制

    Institute of Scientific and Technical Information of China (English)

    刘妹; 顾铁新; 程志中; 黄宏库; 鄢卫东; 鄢明才

    2011-01-01

    Six nutrient-doped soil samples, used as reference materials, were prepared in 1998 but have been used up in the past 10 years. They played an important role in evaluation of soil productivity and ecological geochemistry. To satisfy surveys and evaluations in multi-purpose regional geochemistry and agricultural soil productivity, a series of ten new reference materials ( GBW07412a - GBW07417a, GBW07458 - GBW07461 ) were collected from the main agricultural regions of China and prepared by the Institute of Geophysical and Geochemical Exploration (IGGE ) at in 2009. Six of the ten samples were collected from the same sites as the six samples prepared in 1998, while the others four were collected from western China and calcareous. 50 indices, including nutritious and heavy metal elements, have been certified for all ten materials. These reference materials are more comprehensive and have been more widely distributed than the materials prepared in 1998. Furthermore, to eliminate the influence of analytical method differences in some indices between agricultural and forestry departments, methods of analysis and pretreatment were comprehensively discussed and unified by 13 laboratories from Ministry of Agriculture, Ministry of Land and Resources and Chinese Academy of Sciences.%首批6个土壤有效态成分分析标准物质( GBW07412~ GBW07417),在土壤地力评价和生态农业环境地球化学评价中发挥了重要作用,经十年广泛应用,现已用尽.为满足我国覆盖区多目标地球化学调查与评价及农业土壤地力调查与评价有效态化学成分测试质量监控的需求,2009年中国地质科学院地球物理地球化学勘查研究所研制了新系列土壤有效态成分分析标准物质(GBW07412a~GBW07417a,GBW07458 ~ GBW07461).该系列10个标准物质在原有6个样品采集地重新采集的基础上,新增的4个样品侧重于西部地区和石灰性土壤,使得新研制的有效态成分分析标准物质地域

  9. Use of water activity characteristics enables a simplified approach for defining the reference moisture condition for FDA cocoa powder in-house reference material.

    Science.gov (United States)

    Cunningham, W C

    2013-10-01

    The Food and Drug Administration uses water activity behavior characteristics when adjusting test portion mass to correct for the moisture condition of its cocoa powder in-house reference material. The cocoa powder's moisture condition, and therefore weight, equilibrates according to the relative humidity (RH) of its surroundings. This process is predictable and defined by an isotherm. The reference values in the certificate of analysis are relative to the material's condition at 30% RH, which is assumed to be mid-range for typical laboratory settings. Since mass variations are relatively small within a 15-50% RH range, the mass may be measured immediately after removing a test portion from a storage bottle and used without correction if a standard uncertainty of 0.7% is acceptable for the mass. If greater accuracy is needed and the laboratory RH is known, a very simple and quick procedure can be used whereby the test portion is left open and exposed to the laboratory air overnight before weighing. After applying a correction, the standard uncertainty for mass measurement drops to 0.3%. PMID:23942587

  10. Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2)

    International Nuclear Information System (INIS)

    Bioaccessibility, the fraction of an element solubilized during gastrointestinal digestion and available for absorption, is a factor that should be considered when evaluating the health risk of contaminants from food. Static and dynamic models that mimic human physiological conditions have been used to evaluate bioaccessibility. This preliminary study compares the bioaccessibility of arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in two food certified reference materials (CRMs) (seaweed: Fucus sp., IAEA-140/TM; Lobster hepatopancreas: TORT-2), using two in vitro gastrointestinal digestion methods: a static method (SM) and a dynamic multicompartment method (TIM-1). There are significant differences (p < 0.05) between the bioaccessible values of As, Cd, Pb and Hg obtained by SM and TIM-1 in the two CRMs. The specific form in which the elements studied are present in the CRM may help to explain the bioaccessibility values obtained. - Research Highlights: →Data are reported for As, Cd, Pb and Hg bioaccessibility from food CRMs. →The static and TIM-1 methods give significantly different bioaccessibility values. →The possible influence of speciation on bioaccessibility is discussed. →To improve bioaccessibility quality data, food reference materials are needed.

  11. Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2)

    Energy Technology Data Exchange (ETDEWEB)

    Torres-Escribano, Silvia [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain); Denis, Sylvain; Blanquet-Diot, Stephanie [Clermont Universite, Universite d' Auvergne, Centre de Recherche en Nutrition Humaine Auvergne, ERT 18, Conception ingenierie et developpement de l' aliment et du medicament, BP 10448, F-63000 Clermont-Ferrand (France); Calatayud, Marta [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain); Barrios, Laura [Departamento de Informatica Cientifica (SGAI-CSIC), C/ Pinar 19, 28006 Madrid (Spain); Velez, Dinoraz, E-mail: deni@iata.csic.es [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain); Alric, Monique [Clermont Universite, Universite d' Auvergne, Centre de Recherche en Nutrition Humaine Auvergne, ERT 18, Conception ingenierie et developpement de l' aliment et du medicament, BP 10448, F-63000 Clermont-Ferrand (France); Montoro, Rosa [Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia (Spain)

    2011-01-01

    Bioaccessibility, the fraction of an element solubilized during gastrointestinal digestion and available for absorption, is a factor that should be considered when evaluating the health risk of contaminants from food. Static and dynamic models that mimic human physiological conditions have been used to evaluate bioaccessibility. This preliminary study compares the bioaccessibility of arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in two food certified reference materials (CRMs) (seaweed: Fucus sp., IAEA-140/TM; Lobster hepatopancreas: TORT-2), using two in vitro gastrointestinal digestion methods: a static method (SM) and a dynamic multicompartment method (TIM-1). There are significant differences (p < 0.05) between the bioaccessible values of As, Cd, Pb and Hg obtained by SM and TIM-1 in the two CRMs. The specific form in which the elements studied are present in the CRM may help to explain the bioaccessibility values obtained. - Research Highlights: {yields}Data are reported for As, Cd, Pb and Hg bioaccessibility from food CRMs. {yields}The static and TIM-1 methods give significantly different bioaccessibility values. {yields}The possible influence of speciation on bioaccessibility is discussed. {yields}To improve bioaccessibility quality data, food reference materials are needed.

  12. Preparation of Quartzite Reference Materials for Chemical Composition Analysis%石英岩化学成分分析标准物质研制

    Institute of Scientific and Technical Information of China (English)

    刘調; 马玲; 时晓露; 查立新

    2014-01-01

    At present,quartzitic reference materials are prepared by Brazil,England,Japan,and South Africa but are not in series. The SiO2 contents in these reference materials are generally above 96% and accurate concentration values are determined for only small number of elements.To date,no quartzitic reference material has been prepared in China,which cannot meet the demand of quartzite exploration and practical applications.In this study,three quartzitic reference materials were developed with samples from representative quartz mining areas,namely Damiao Town, Fengyang County, Anhui Province;Jingyang Town, Datong County, Qinghai Province;and Lingqiu mountain,Qichun County,Hubei Province.The samples were finely crushed to -45 μm with a fluidized bed-type airflow crusher to prevent sample contamination.Homogeneity and stability testing was conducted chiefly by Inductively Coupled Plasma-Atomic Emission Spectrometry and Inductively Coupled Plasma-Mass Spectrometry rather than X-ray Fluorescence Spectrometry with tablet sample preparation,which results in the quartzite material being difficult to mould.F values for the variance test were less than the threshold,which indicated a good homogeneity.No significant statistical changes were observed in eight two-year stability tests.The short-term stability analysis in the condition of extreme temperatures and vibration were also consistent.Determined values were certified by 1 0 laboratories in China with multiple methods.For components without homogeneity and stability tests,values and relative uncertainty of 36 components were obtained by comparing similar elements.The three quartzitic reference materials have been approved as national standard reference materials (GBW 07835 , GBW07836 and GBW 07837),with 92.93%,95.97% and 99.18% of SiO2,respectively,as a gradient distributed series.The series of reference materials has the characteristics of uniform grading,narrow diameter distribution (D25 -D75 ranged between 4 -1 6

  13. Feasibility study for producing a carrot/potato matrix reference material for 11 selected pesticides at EU MRL level: material processing, homogeneity and stability assessment.

    Science.gov (United States)

    Saldanha, Helena; Sejerøe-Olsen, Berit; Ulberth, Franz; Emons, Hendrik; Zeleny, Reinhard

    2012-05-01

    The feasibility for producing a matrix reference material for selected pesticides in a carrot/potato matrix was investigated. A commercially available baby food (carrot/potato-based mash) was spiked with 11 pesticides at the respective EU maximum residue limits (MRLs), and further processed by either freezing or freeze-drying. Batches of some 150 units were produced per material type. First, the materials were assessed for the relative amount of pesticide recovered after processing (ratio of pesticide concentration in the processed material to the initially spiked pesticide concentration). In addition, the materials' homogeneity (bottle-to-bottle variation), and the short-term (1 month) and mid-term (5 months) stability at different temperatures were assessed. For this, an in-house validated GC-EI-MS method operated in the SIM mode with a sample preparation procedure based on the QuEChERS ("quick, easy, cheap, effective, rugged, and safe") principle was applied. Measurements on the frozen material provided the most promising results (smallest analyte losses during production), and also freeze-drying proved to be a suitable alternative processing technique for most of the investigated pesticides. Both the frozen and the freeze-dried material showed to be sufficiently homogeneous for the intended use, and storage at -20°C for 5 months did not reveal any detectable material degradation. The results constitute an important step towards the development of a pesticide matrix reference material. PMID:26434333

  14. Doorways II: Community Counselor Reference Materials. On School-Related Gender-Based Violence Prevention and Response

    Science.gov (United States)

    US Agency for International Development, 2009

    2009-01-01

    The Doorways training program was designed by the U.S. Agency for International Development (USAID)-funded Safe Schools Program (Safe Schools) to enable teachers, community members and students to prevent and respond to school-related gender-based violence (SRGBV). This booklet, "Doorways II: Community Counselor Reference Materials on…

  15. Development of a reference material for Staphylococcus aureus enterotoxin A in cheese: feasibility study, processing, homogeneity and stability assessment.

    Science.gov (United States)

    Zeleny, R; Emteborg, H; Charoud-Got, J; Schimmel, H; Nia, Y; Mutel, I; Ostyn, A; Herbin, S; Hennekinne, J-A

    2015-02-01

    Staphylococcal food poisoning is caused by enterotoxins excreted into foods by strains of staphylococci. Commission Regulation 1441/2007 specifies thresholds for the presence of these toxins in foods. In this article we report on the progress towards reference materials (RMs) for Staphylococcal enterotoxin A (SEA) in cheese. RMs are crucial to enforce legislation and to implement and safeguard reliable measurements. First, a feasibility study revealed a suitable processing procedure for cheese powders: the blank material was prepared by cutting, grinding, freeze-drying and milling. For the spiked material, a cheese-water slurry was spiked with SEA solution, freeze-dried and diluted with blank material to the desired SEA concentration. Thereafter, batches of three materials (blank; two SEA concentrations) were processed. The materials were shown to be sufficiently homogeneous, and storage at ambient temperature for 4weeks did not indicate degradation. These results provide the basis for the development of a RM for SEA in cheese. PMID:25172706

  16. 24 CFR 1710.504 - Cooperation among certified states and between certified states and the Secretary.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Cooperation among certified states....504 Cooperation among certified states and between certified states and the Secretary. (a) By filing... exceed the federal standard provided that such requirements are not in conflict with the Act or...

  17. Metrological aspects related to stable isotope reference materials: the traceability concept and uncertainty evaluation scheme supporting every day practice.

    Science.gov (United States)

    Assonov, Sergey; Groening, Manfred; Fajgelj, Ales

    2016-04-01

    The worldwide metrological comparability of stable isotope measurement results is presently achieved by linking them to the conventional delta scales. Delta scales are realized by scale defining reference materials, most of them being supplied by the IAEA (examples are VSMOW2 & SLAP2). In fact, these reference materials are artefacts, characterized by a network of laboratories using the current best measurement practice. In reality any measurement result is linked to the scale via reference materials (RMs) in use. Any RMs is traceable to the highest-level RMs which define the scale; this is valid not only for international RMs (mostly secondary RMs like IAEA-CH-7, NBS22) but for any lab standard calibrated by users. This is a basic of measurement traceability. The traceability scheme allows addressing both the comparability and long-term compatibility of measurement results. Correspondingly, the uncertainty of any measurement result has to be propagated up to the scale level. The uncertainty evaluation should include (i) the uncertainty of the RMs in use; (ii) the analytical uncertainty of the materials used in calibration runs performed at the user laboratory; (iii) the reproducibility on results obtained on sample material; (iv) the uncertainty of corrections applied (memory, drift, etc). Besides these, there may be other uncertainty components of to be considered. The presentation will illustrate the metrological concepts involved (comparability, traceability etc) and give a generic scheme for the uncertainty evaluation.

  18. Preparation and Certification of Acephate in Acetone Reference Material%乙酰甲胺磷丙酮溶液标准物质的制备及定值

    Institute of Scientific and Technical Information of China (English)

    张葳葳; 张蕊; 王晓亮

    2012-01-01

    采用乙酰甲胺磷纯度标准物质为原料,以丙酮为溶剂,制备了浓度为1.00 mg/mL的乙酰甲胺磷丙酮溶液标准物质,用液相色谱法和气相色谱法进行了确认,A类标准不确定度为0.009%,B类标准不确定度包括标准物质制备、原料纯度、不均匀性和不稳定性引入的不确定度,其量值分别为0.43%,0.10%,0.87%和0.24%,合成不确定度为0.03 mg/mL(k=2),乙酰甲胺磷丙酮溶液标准物质的浓度为(1.00±0.03) mg/mL.%Acephate in acetone reference material with 1.00 mg / Ml was prepared by using purity reference material. The concentration was assessed by gas chromatography - flame ionization detector (FID), high-performance liquid chromatography-diode array detection (HPLC-DAD), respectively. The uncertainty of certified value was estimated including the uncertainty of the measurement repeatability (0.009%), solution preparation (0.43%), purity reference material(0.10%), unhomogeneity (0.87%) and instability (0.24%). The expanded uncertainty was 0.03 mg/Ml(k=2). The concentration value for acephate was (1.00 ±0.03) mg/Ml.

  19. A study of mechanical behavior of rock-fill materials with reference to particle crushing

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In rock-fill dams of 200 to 300 m high,maximum compressive stress can exceed 6MPa.At such a high stress level,rock-fill materials may experience particle crushing during shear.The material behavior is highly sophisticated exhibiting pressure and density dependency as well as particle crushing effects.Through scrutinizing the relevant experimental data on rock-fill materials and sands published in the literatures,this paper is focused on understanding basic mechanical characteristics of this sort of materials in the light of constitutive modelling.

  20. The preparation and analysis of minerals for use as reference material

    International Nuclear Information System (INIS)

    This report covers the progress made in the collection of reference samples, and describes the completion of the five interlaboratory analytical programmes (those on ferrochromium slags, fluorspar, 'mixed' NIMROC samples, rare earths, and ferromanganese slags). A comprehensive tabulation of the samples that have been evaluated, and a list of the samples that have not been evaluated are included

  1. Developing a Reference Material for Diffusion-Controlled Formaldehyde Emissions Testing

    Science.gov (United States)

    Emissions of formaldehyde from building materials can contaminate indoor air and create significant risks to human health. The need to control formaldehyde emissions from indoor materials is made more urgent by the prevailing drive to improve building energy by decreasing ventil...

  2. Nutrition Education Materials and Audiovisuals for Grades Preschool through 6. Special Reference Briefs Series.

    Science.gov (United States)

    Evans, Shirley King, Comp.

    This bibliography was prepared for educators interested in nutrition education materials, audiovisuals, and resources for classroom use. Items listed cover a range of topics including general nutrition, food preparation, food science, and dietary management. Teaching materials listed include food models, games, kits, videocassettes, and lesson…

  3. Preparation of two biological reference materials for QUASIMEME inter-laboratory testing

    NARCIS (Netherlands)

    Lohman, M.; Korytar, P.

    2007-01-01

    Two biological materials have been prepared for the Institute for Environmental Studies (IVM), Free University, Amsterdam to be used in QUASIMEME interlaboratory studies. The materials prepared are: 300 tins of homogenized blue mussels from the Waddenzee (QO07-1) and 300 tins of homogenized shrimps

  4. Preparation of three biological reference material for QUASIMEME inter-laboratory testing

    NARCIS (Netherlands)

    Lohman, M.; Korytar, P.

    2006-01-01

    Three biological materials have been prepared for IVM, Free University, Amsterdam to be used in QUASIMEME interlaboratory studies. The materials prepared are: 300 glass jars of homogenized Mediterranean mussels (QM06-1), 280 tins of homogenized blue mussels from German Bight (QM06-3) and 300 tins of

  5. Application of direct solid sample analysis for the determination of chlorine in biological materials using electrothermal vaporization inductively coupled plasma mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Santos de Gois, Jefferson; Pereira, Éderson R. [Departamento de Química, Universidade Federal de Santa Catarina, 88040-970 Florianópolis, SC (Brazil); Welz, Bernhard [Departamento de Química, Universidade Federal de Santa Catarina, 88040-970 Florianópolis, SC (Brazil); INCT de Energia e Ambiente do CNPq (Brazil); Borges, Daniel L.G., E-mail: daniel.borges@ufsc.br [Departamento de Química, Universidade Federal de Santa Catarina, 88040-970 Florianópolis, SC (Brazil); INCT de Energia e Ambiente do CNPq (Brazil)

    2015-03-01

    This work describes a methodology developed to carry out Cl determination in biological materials using electrothermal vaporization inductively coupled plasma mass spectrometry and direct solid sample analysis. The solid samples were directly weighed into graphite ‘cups’ and inserted into the graphite furnace. The RF power and the carrier gas flow rate were optimized at 1300 W and 0.7 L min{sup −1}, respectively. Calibration could be carried out using aqueous standard solutions with pre-dried modifiers (Pd + Nd or Pd + Ca) or using solid certified reference materials with the same pre-dried modifiers or without the use of modifiers. The limit of quantification was determined as 5 μg g{sup −1} under optimized conditions and the Cl concentration was determined in five certified reference materials with certified concentrations for Cl, in addition to three certified reference materials, for which certified values for Cl were unavailable; in the latter case, the results were compared with those obtained using high-resolution continuum source molecular absorption spectrometry. Good agreement at a 95% statistical confidence level was achieved between determined and certified or reference values. - Highlights: • Direct determination of chlorine in solid biological materials is described for the first time using ICP-MS. • Calibration against aqueous standards is feasible. • The method is accurate and sensitive, regardless of the composition of the solid sample.

  6. Application of direct solid sample analysis for the determination of chlorine in biological materials using electrothermal vaporization inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    This work describes a methodology developed to carry out Cl determination in biological materials using electrothermal vaporization inductively coupled plasma mass spectrometry and direct solid sample analysis. The solid samples were directly weighed into graphite ‘cups’ and inserted into the graphite furnace. The RF power and the carrier gas flow rate were optimized at 1300 W and 0.7 L min−1, respectively. Calibration could be carried out using aqueous standard solutions with pre-dried modifiers (Pd + Nd or Pd + Ca) or using solid certified reference materials with the same pre-dried modifiers or without the use of modifiers. The limit of quantification was determined as 5 μg g−1 under optimized conditions and the Cl concentration was determined in five certified reference materials with certified concentrations for Cl, in addition to three certified reference materials, for which certified values for Cl were unavailable; in the latter case, the results were compared with those obtained using high-resolution continuum source molecular absorption spectrometry. Good agreement at a 95% statistical confidence level was achieved between determined and certified or reference values. - Highlights: • Direct determination of chlorine in solid biological materials is described for the first time using ICP-MS. • Calibration against aqueous standards is feasible. • The method is accurate and sensitive, regardless of the composition of the solid sample

  7. Using high-performance ¹H NMR (HP-qNMR®) for the certification of organic reference materials under accreditation guidelines--describing the overall process with focus on homogeneity and stability assessment.

    Science.gov (United States)

    Weber, Michael; Hellriegel, Christine; Rueck, Alexander; Wuethrich, Juerg; Jenks, Peter

    2014-05-01

    Quantitative NMR spectroscopy (qNMR) is gaining interest across both analytical and industrial research applications and has become an essential tool for the content assignment and quantitative determination of impurities. The key benefits of using qNMR as measurement method for the purity determination of organic molecules are discussed, with emphasis on the ability to establish traceability to "The International System of Units" (SI). The work describes a routine certification procedure from the point of view of a commercial producer of certified reference materials (CRM) under ISO/IEC 17025 and ISO Guide 34 accreditation, that resulted in a set of essential references for (1)H qNMR measurements, and the relevant application data for these substances are given. The overall process includes specific selection criteria, pre-tests, experimental conditions, homogeneity and stability studies. The advantages of an accelerated stability study over the classical stability-test design are shown with respect to shelf-life determination and shipping conditions. PMID:24182847

  8. Fluorescence anisotropy measurements in solution: Methods and reference materials (IUPAC Technical Report)

    OpenAIRE

    Ameloot, Marcel; vandeVen, Martin; Ulises Acuna, A.; Valeur, Bernard

    2013-01-01

    After recalling the basic relations relevant to both steady-state and time-resolved fluorescence polarization, it is shown how the values of steady-state polarized intensities recorded experimentally usually need to be corrected for systematic effects and errors, caused by instrumentation and sample properties. A list of selected reference values of steady-state fluorescence anisotropy and polarization is given. Attention is also paid to analysis of time-resolved fluorescence anisotropy data ...

  9. Intralaboratory comparison experiments for plutonium determination in working reference material K4Pu (SO4)4: coulometry and biamperometry

    International Nuclear Information System (INIS)

    Accurate and precise determination of Pu in reactor fuel materials is essential for the characterization of the fuel as well as for fissile material accounting. Electroanalytical methods like Coulometry, Potentiometry , and Biamperometry based on the redox reactions are widely employed for determination of Pu at milligram levels. Controlled potential coulometry is a well established routinely employed technique for precise and accurate determination of plutonium. A biamperometric method based on the Pu(VI)-Pu(IV) redox couple has been in routine use for Pu determination in a variety of nuclear fuel materials in our laboratory for past 25 years. In order to validate the status of the methodologies employed for Pu determination an intralaboratory comparison experiments involving Pu determination in working reference material K4Pu(SO4)4 was conducted. Results of these studies are presented in this paper

  10. The role of instrumental activation analysis in the verification and completion of analytical data of rock reference materials

    International Nuclear Information System (INIS)

    Ten selected rock reference materials (USGS diabase W-l, basalt BCR-1, andesite AGV-1, granite G-2, granodiorite GSP-1, and CRPG basalt BE-N, granite GS-N, trachyte ISH-G, serpentine UB-N, glass standard VS-N) were analyzed by instrumental neutron and photon activation analyses. The results were evaluated on average for the entire set of samples to detect possible systematic deviations of the determined values from the reference values. Out of 47 elements determined, 43 elements were determined with reasonable agreement (deviation <10% on average) with the reference values. Au could not be determined because of a high blank from packaging polyethylene foil. Systematically higher Dy and lower Ho and Tm (by about 20 % on average) in our results require further investigation. In several cases, reasons for greater differences between the determined and recommended values could not be traced in our procedures. The most suspect is the recommended value for W in the CRPG BE-N basalt, which is twenty-five times higher than the value determined in the present work, probably due to inconsistent contamination from a W carbide mill used in production of this reference material. (author)

  11. Material investigation for manufacturing of reference step gauges for CT scanning verification

    DEFF Research Database (Denmark)

    Cantatore, Angela; Angel, Jais Andreas Breusch; De Chiffre, Leonardo

    2012-01-01

    . The material was unstable, probably due to a modification of the chemical composition which lowered the hardness. New step gauges were manufactured through milling. Polyetheretherketone (PEEK) and Polyp-phenylenesulphide (PPS with 40% glass) fulfil the requirements regarding hardness and mechanical properties...... and two series of five step gauges (one series for each material) were manufactured by milling. Results show a significant improvement in terms of form stability and surface geometry quality of the new step gauges with respect to the replica step gauges in Luxabite, as reported below.......This work deals with the study of stability and material investigation for manufacturing of step gauges for CT scanning verification. Four replica step gauges were fabricated using a bisacryl material for dental applications and the stability over five months was monitored using a tactile CMM...

  12. Elemental analysis of biological materials. Current problems and techniques with special reference to trace elements

    International Nuclear Information System (INIS)

    Selected techniques were reviewed for the assay of trace and minor elements in biological materials. Other relevant information is also presented on the need for such analyses, sampling, sample preparation and analytical quality control. In order to evaluate and compare the applicability of the various analytical techniques on a meaningful and objective basis, the materials chosen for consideration were intended to be typical of a wide range of biological matrics of different elemental compositions, namely Bowen's kale, representing a plant material, and NBS bovine liver, IAEA animal muscle, and blood serum, representing animal tissues. The subject is reviewed under the following headings: on the need for trace element analyses in the life sciences (4 papers); sampling and sample preparation for trace element analysis (2 papers); analytical techniques for trace and minor elements in biological materials (7 papers); analytical quality control (2 papers)

  13. Comprehensive Pb-Sr-Nd-Hf isotopic, trace element, and mineralogical characterization of mafic to ultramafic rock reference materials

    Science.gov (United States)

    Fourny, Anaïs.; Weis, Dominique; Scoates, James S.

    2016-03-01

    Controlling the accuracy and precision of geochemical analyses requires the use of characterized reference materials with matrices similar to those of the unknown samples being analyzed. We report a comprehensive Pb-Sr-Nd-Hf isotopic and trace element concentration data set, combined with quantitative phase analysis by XRD Rietveld refinement, for a wide range of mafic to ultramafic rock reference materials analyzed at the Pacific Centre for Isotopic and Geochemical Research, University of British Columbia. The samples include a pyroxenite (NIM-P), five basalts (BHVO-2, BIR-1a, JB-3, BE-N, GSR-3), a diabase (W-2), a dolerite (DNC-1), a norite (NIM-N), and an anorthosite (AN-G); results from a leucogabbro (Stillwater) are also reported. Individual isotopic ratios determined by MC-ICP-MS and TIMS, and multielement analyses by HR-ICP-MS are reported with 4-12 complete analytical duplicates for each sample. The basaltic reference materials have coherent Sr and Nd isotopic ratios with external precision below 50 ppm (2SD) and below 100 ppm for Hf isotopes (except BIR-1a). For Pb isotopic reproducibility, several of the basalts (JB-3, BHVO-2) require acid leaching prior to dissolution. The plutonic reference materials also have coherent Sr and Nd isotopic ratios (<50 ppm), however, obtaining good reproducibility for Pb and Hf isotopic ratios is more challenging for NIM-P, NIM-N, and AN-G due to a variety of factors, including postcrystallization Pb mobility and the presence of accessory zircon. Collectively, these results form a comprehensive new database that can be used by the geochemical community for evaluating the radiogenic isotope and trace element compositions of volcanic and plutonic mafic-ultramafic rocks.

  14. Combating illicit trafficking in nuclear and other radioactive material. Technical guidance. Reference manual. (Chinese Edition)

    International Nuclear Information System (INIS)

    This publication is intended for individuals and organizations that may be called upon to deal with the detection of and response to criminal or unauthorized acts involving nuclear or other radioactive material. It will also be useful for legislators, law enforcement agencies, government officials, technical experts, lawyers, diplomats and users of nuclear technology. This manual emphasizes the international initiatives for improving the security of nuclear and other radioactive material. However, it is recognized that effective measures for controlling the transfer of equipment, non-nuclear material, technology or information that may assist in the development of nuclear explosive devices, improvised nuclear devices (INDs) or other radiological dispersal devices (RDDs) are important elements of an effective nuclear security system. In addition, issues of personal integrity, inspection and investigative procedures are not discussed in this manual, all of which are essential elements for an effective overall security system. The manual considers a variety of elements that are recognized as being essential for dealing with incidents of criminal or unauthorized acts involving nuclear and other radioactive material. Depending on conditions in a specific State, including its legal and governmental infrastructure, some of the measures discussed will need to be adapted to suit that State's circumstances. However, much of the material can be applied directly in the context of other national programmes. This manual is divided into four main parts. Section 2 discusses the threat posed by criminal or unauthorized acts involving nuclear and other radioactive material, as well as the policy and legal bases underlying the international effort to restrain such activities. Sections 3 and 4 summarize the major international undertakings in the field. Sections 5-8 provide some basic technical information on radiation, radioactive material, the health consequences of radiation

  15. Use of 15N in nitrification inhibitor studies with special reference to indigenous materials

    International Nuclear Information System (INIS)

    Non-edible oil seed cakes and their constituents have been advantageously used for increasing the efficiency of fertilizer nitrogen (N) for crop production. The beneficial effects of these materials have been attributed to retardation of nitrification, which lessen the loss of N associated with nitrification by leaching and denitrification in situations where these losses are high. However, it is possible that some of the effects of these materials could be due to immobilization-remineralization of N particularly when the carbonaceous materials are added with fertilizers at high rates. A methodology involving the use of 15N-labelled fertilizers is advanced to sort out whether the beneficial effects of non-edible oil seed cakes and other materials are due to retardation of nitrification and or immobilization-remineralization of fertilizer N. Using the proposed technique it would be possible to make realistic evaluation of the wealth of indigenous products as nitrification inhibitors. Following the proposed approach it would also be possible to widen the scope and depth of research in this area for ultimately better exploitation of indigenous materials as nitrification inhibitors. (author). 18 refs

  16. Comprehensive inter-laboratory calibration of reference materials for δ18O versus VSMOW using various on-line high-temperature conversion techniques

    Science.gov (United States)

    Brand, Willi A.; Coplen, Tyler B.; Aerts-Bijma, Anita T.; Böhlke, J.K.; Gehre, Matthias; Geilmann, Heike; Groning, Manfred; Jansen, Henk G.; Meijer, Harro A. J.; Mroczkowski, Stanley J.; Qi, Haiping; Soergel, Karin; Stuart-Williams, Hilary; Weise, Stephan M.; Werner, Roland A.

    2009-01-01

    Internationally distributed organic and inorganic oxygen isotopic reference materials have been calibrated by six laboratories carrying out more than 5300 measurements using a variety of high-temperature conversion techniques (HTC)a in an evaluation sponsored by the International Union of Pure and Applied Chemistry (IUPAC). To aid in the calibration of these reference materials, which span more than 125‰, an artificially enriched reference water (δ18O of +78.91‰) and two barium sulfates (one depleted and one enriched in 18O) were prepared and calibrated relative to VSMOW2b and SLAP reference waters. These materials were used to calibrate the other isotopic reference materials in this study, which yielded: Reference materialδ18O and estimated combined uncertainty c IAEA-602 benzoic acid

  17. Comprehensive inter-laboratory calibration of reference materials for d18O versus VSMOW using various on-line high-temperature conversion techniques

    Science.gov (United States)

    Coplen, Tyler B.; Bohlke, Johnkarl F.; Mroczkowski, Stanley J.; Qi, Haiping; Brand, Willi A.; Aerts-Bijma, Anita T.; Gehre, Matthias; Geilmann, Heike; Groning, Manfred

    2009-01-01

    "Internationally distributed organic and inorganic oxygen isotopic reference materials have been calibrated by six laboratories carrying out more than 5300 measurements using a variety of high-temperature conversion techniques (HTC) in an evaluation sponsored by the International Union of Pure and Applied Chemistry (IUPAC). To aid in the calibration of these reference materials, which span more than 125‰, an artificially enriched reference water (d18O of +78.91‰) and two barium sulfates (one depleted and one enriched in 18O) were prepared and calibrated relative to VSMOW2 and SLAP reference waters. These materials were used to calibrate the other isotopic reference materials in this study, which yielded: Reference material d18O and estimated combined uncertainty

  18. Kant's Understanding of the Enlightenment with Reference to his Refutation of Materialism

    OpenAIRE

    Paola Rumore

    2014-01-01

    The paper focuses on the role of Kant’s refutation of materialism in his understanding of the Enlightenment, meant to be the necessary condition that allows human beings to express their proper dignity, i.e. to cultivate the urge for and the vocation of free thought. Sketching the main moments of the German struggle against the threat of materialism, the paper places Kant’s refutation within this tradition, and reconstructs the steps of his critique from the very beginning of his ...

  19. Marine mammal blubber reference and control materials for use in the determination of halogenated organic compounds and fatty acids

    Energy Technology Data Exchange (ETDEWEB)

    Kucklick, John R.; Pugh, Rebecca S.; Becker, Paul R. [Hollings Marine Laboratory, National Institute of Standards and Technology (NIST), Charleston, SC (United States); Schantz, Michele M.; Porter, Barbara J.; Poster, Dianne L.; Leigh, Stefan; Wise, Stephen A. [NIST, Analytical Chemistry Division, Gaithersburg, MD (United States); Rowles, Teri K. [National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Silver Spring, MD (United States)

    2010-05-15

    The National Institute of Standards and Technology (NIST) has a diverse collection of control materials derived from marine mammal blubber, fat, and serum. Standard Reference Material (SRM) 1945 Organics in Whale Blubber was recertified for polychlorinated biphenyl (PCB) congeners, organochlorine pesticides, and polybrominated diphenyl ether (PBDE) congeners. SRM 1945 has also been assigned mass fraction values for compounds not frequently determined in marine samples including toxaphene congeners, coplanar PCBs, and methoxylated PBDE congeners which are natural products. NIST also has assigned mass fraction values, as a result of interlaboratory comparison exercises, for PCB congeners, organochlorine pesticides, PBDE congeners, and fatty acids in six homogenate materials produced from marine mammal blubber or serum. The materials are available from NIST upon request; however, the supply is very limited for some of the materials. The materials include those obtained from pilot whale blubber (Homogenates III and IV), Blainville's beaked whale blubber (Homogenate VII), polar bear fat (Homogenate VI), and California sea lion serum (Marine Mammal Control Material-1 Serum) and blubber (Homogenate V). (orig.)

  20. HISTORIC ENERGY STAR Certified Room Air Cleaners

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 1.2 ENERGY STAR Program Requirements for Room Air Cleaners that are effective as of July...

  1. Radioactive solutions and reagents with certified activity

    International Nuclear Information System (INIS)

    An international directory of radioactive solutions and reagents with certified activity is compiled. Data are given in tables on radioactivity concentration, uncertainty, volume, supplier, availability and form of solutions and reagents

  2. ENERGY STAR Certified Commercial Refrigerators and Freezers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Commercial Refrigerators and Freezers that are...

  3. ENERGY STAR Certified Data Center Storage

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 1.0 ENERGY STAR Program Requirements for Data Center Storage that are effective as of...

  4. ENERGY STAR Certified Residential Clothes Dryers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 1.0 ENERGY STAR Program Requirements for Clothes Dryers that are effective as of January...

  5. ENERGY STAR Certified Light Commercial HVAC

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Light Commercial HVAC that are effective as of...

  6. ENERGY STAR Certified Small Network Equipment

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 1.0 ENERGY STAR Program Requirements for Small Networking Equipment that are effective...

  7. ENERGY STAR Certified Commercial Clothes Washers

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 7.0 ENERGY STAR Program Requirements for Clothes Washers that are effective as of March...

  8. ENERGY STAR Certified Geothermal Heat Pumps

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Geothermal Heat Pumps that are effective as of...

  9. ENERGY STAR Certified Uninterruptible Power Supplies

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 1.0 ENERGY STAR Program Requirements for Uninterruptible Power Supplies that are...

  10. Adolescent Mental Health: Selected Materials from the NCEMCH Reference Collection, April 1997.

    Science.gov (United States)

    National Center for Education in Maternal and Child Health, Arlington, VA.

    Items in this annotated bibliography deal with the mental health of adolescents and include materials for adolescents, parents, health educators, and health professionals. Resources cited include 11 videotapes and 64 publications dealing with the following topics: (1) teenage suicide; (2) mental illness in the family; (3) coping; (4) teenage…

  11. Kant's Understanding of the Enlightenment with Reference to his Refutation of Materialism

    Directory of Open Access Journals (Sweden)

    Paola Rumore

    2014-11-01

    Full Text Available The paper focuses on the role of Kant’s refutation of materialism in his understanding of the Enlightenment, meant to be the necessary condition that allows human beings to express their proper dignity, i.e. to cultivate the urge for and the vocation of free thought. Sketching the main moments of the German struggle against the threat of materialism, the paper places Kant’s refutation within this tradition, and reconstructs the steps of his critique from the very beginning of his reflection – still dealing with the main topics of Wolff’s metaphysic – up to the definitive refutation he develops on the basis of the transcendental idealism of the first Critique. The shift from the «obscure reasons» pointed out in the Dreams, that allow a refutation of materialism on moral grounds, to the statement of the meaninglessness of the question in a transcendental perspective reveals that the attempt to find a solution to the problem of materialism – most of all in its psychological meaning –represents a neverending challenge within Kant’s reflection.

  12. A pointer logic and certifying compiler

    Institute of Scientific and Technical Information of China (English)

    CHEN Yiyun; GE Lin; HUA Baojian; LI Zhaopeng; LIU Cheng; WANG Zhifang

    2007-01-01

    Proof-Carrying Code brings two big challenges to the research field of programming languages.One is to seek more expressive logics or type systems to specify or reason about the properties of low-level or high-level programs.The other is to study the technology of certifying compilation in which the compiler generates proofs for programs with annotations.This paper presents our progress in the above two aspects.A pointer logic was designed for PointerC (a C-like programming language) in our research.As an extension of Hoare logic,our pointer logic expresses the change of pointer information for each statement in its inference rules to support program verification.Meanwhile,based on the ideas from CAP (Certified Assembly Programming) and SCAP (Stack-based Certified Assembly Programming),a reasoning framework was built to verify the properties of object code in a Hoare style.And a certifying compiler prototype for PointerC was implemented based on this framework.The main contribution of this paper is the design of the pointer logic and the implementation of the certifying compiler prototype.In our certifying compiler,the source language contains rich pointer types and operations and also supports dynamic storage allocation and deallocation.

  13. Iron Disilicide as High-Temperature Reference Material for Traceable Measurements of Seebeck Coefficient Between 300 K and 800 K

    Science.gov (United States)

    Ziolkowski, Pawel; Stiewe, Christian; de Boor, Johannes; Druschke, Ines; Zabrocki, Knud; Edler, Frank; Haupt, Sebastian; König, Jan; Mueller, Eckhard

    2016-09-01

    Thermoelectric generators (TEGs) convert heat to electrical energy by means of the Seebeck effect. The Seebeck coefficient is a central thermoelectric material property, measuring the magnitude of the thermovoltage generated in response to a temperature difference across a thermoelectric material. Precise determination of the Seebeck coefficient provides the basis for reliable performance assessment in materials development in the field of thermoelectrics. For several reasons, measurement uncertainties of up to 14% can often be observed in interlaboratory comparisons of temperature-dependent Seebeck coefficient or in error analyses on currently employed instruments. This is still too high for an industrial benchmark and insufficient for many scientific investigations and technological developments. The TESt (thermoelectric standardization) project was launched in 2011, funded by the German Federal Ministry of Education and Research (BMBF), to reduce measurement uncertainties, engineer traceable and precise thermoelectric measurement techniques for materials and TEGs, and develop reference materials (RMs) for temperature-dependent determination of the Seebeck coefficient. We report herein the successful development and qualification of cobalt-doped β-iron disilicide (β-Fe0.95Co0.05Si2) as a RM for high-temperature thermoelectric metrology. A brief survey on technological processes for manufacturing and machining of samples is presented. Focus is placed on metrological qualification of the iron disilicide, results of an international round-robin test, and final certification as a reference material in accordance with ISO-Guide 35 and the "Guide to the expression of uncertainty in measurement" by the Physikalisch-Technische Bundesanstalt, the national metrology institute of Germany.

  14. Assessment of Materialism and Reference Group Influence on Preference for Western Branded Fabrics in Maiduguri, Borno State, Nigeria

    Directory of Open Access Journals (Sweden)

    Mohammed Abba

    2013-01-01

    Full Text Available This paper investigates how materialism and reference group influence may affect consumers’ preference for western branded fabrics. Data for the study was collected through questionnaire administered on a sample of 26 respondents. The respondents were selected using convenient sampling through snowball from a population of male and female professional workers aged 18 and above. Data collected from the primary source (questionnaire was analyzed using simple percentage. Findings revealed that materialism had no significant influence on their preferences for western branded fabrics. Reference groups, however, significantly influenced respondents’ decision to purchase Western branded fabrics. It was concluded that although some of the behaviors of the sampled group were quite materialistic, they were not enhanced by associations with Western branded fabrics and their related cultural values. Based on the findings, it was recommended that marketers of western brands in Borno state, particularly in the state capital can do well if they adopt a strategy of deliberately targeting and nurturing of their consumers’ reference groups, rather than attempt to position their products on the basis of inherent materialistic values.

  15. Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat

    NARCIS (Netherlands)

    Grombe, R.; Allmaier, G.; Charoud-Got, J.; Dudkiewicz, A.; Emteborg, H.; Hofmann, T.; Huusfeldt-Larsen, E.; Lehner, A.; Llinas, M.; Loeschner, K.; Molhave, K.; Peters, R.J.B.; Seghers, J.; Solans, C.; Kammer, van den F.; Wagner, S.; Weigel, S.; Linsinger, T.P.J.

    2015-01-01

    The feasibility of producing colloidal silver nanoparticle reference materials and silver nanoparticle spiked reference matrix materials was investigated. Two concentrations of PVP-coated silver nanoparticle dispersions were evaluated and used to spike chicken meat, with the aim of producing a set o

  16. Dynamics of a material point in a noninertial frame of reference

    Energy Technology Data Exchange (ETDEWEB)

    Verozub, L.V. (Khar' kovskij Gosudarstvennyj Univ. (Ukrainian SSR))

    1981-10-01

    Elements of material point dynamics in noninertial counting systems (NCS), where space-time is suggested to be pseudofinsler, are investigated. Considered were methods analogous for inertial counting systems for description of the physical system state change in time and based on equations of motion for dynamical variables and on the Hamilton-Jakobi equations. It is shown, in particular, that the presence of inertial forces in NCS may be interpreted as manifestation of difference of space-time in the latter from pseudoeuclidean. Such interpretation is alternative to the known interpretation of inertial forces in NCS as hypothetical force effect of the rest substance of Universe.

  17. Examples of reference material data needed for LBB analysis derived from WGCS-EC-DGXI studies

    Energy Technology Data Exchange (ETDEWEB)

    Petrequin, P.; Houssin, B.; Guinovart, J.

    1997-04-01

    Mechanical data collected through the sponsorship of the Activity Group 3 <<Materials>> of the Working Group Codes and Standards of DG XI European Commission are pointed out to illustrate their potential use for Leak Before Break analyses. Most of the tensile, fatigue, creep and fracture toughness data have been generated for stainless steels, mainly on modified type 316 L (N), selected for the Super Phoenix LMFBR. Trends for ongoing programs and future works on C-Mn and MnNiMo low alloy steels are provided.

  18. 甲苯中苯标准物质的研制%Development of reference material of benzene in toluene

    Institute of Scientific and Technical Information of China (English)

    张苏敏; 张毅; 代妍; 何丘

    2012-01-01

    以甲苯和苯为原料,采用称量-容量法研制了浓度为5 mg/mL的甲苯中苯溶液标准物质.所研制的标准物质通过均匀性检验、稳定性检验和与GBW(E) 130101的比对,标准值的相对扩展不确定度为3%(k=2),有效期限为24 m.%A kind of reference material of benzene in toluene was prepared using benzene and toluene as raw materials by Gravimetric-Volume Method. The standard value of concentration is 5 mg/mL. The reference material passed the homogeneity inspection, stability examination and intercomparison test between it and GBW(E) 130101. The relative expanded uncertainty of the concentration standard value is 3% (A = 2). The validity period is 24 m.

  19. Preparation, characterization and use of a reference material to proficiency testing for determination of metals in fish tissue in natura

    International Nuclear Information System (INIS)

    The proficiency tests are widely used to evaluate the analytical capacity of laboratories and also as part of the accreditation process. For this reason, are important tools for the control of the quality of the analytical results obtained in the laboratories that work directly with seafood companies. In Brazil there are no providers of proficiency testing for metals potentially toxic in fish tissues. In this work will be described all steps used for the production of reference materials to be used in a proficiency testing pilot study for As, Cd, Pb and Hg in fish tissue following the recommendations of the ISO Guide 35. He preparation scheme consisted in selecting the individuals, cleaning, grinding, homogenization and fortification with As, Cd and Pb in two concentration levels. The preparation resulted in 164 sachets of 10 g each. In order to evaluate the effect of gamma irradiation in the samples conservation 52 sachets were irradiated with 60Co (10.00 ± 1.05 kGy) in a gamma cell. This material with others non irradiated 52 sachets were used for the homogeneity and stability studies. The remaining 60 were used for the proficiency testing. The results demonstrated that both materials were homogeneous and presented good stability (during a period of 45 days). However, the irradiated material present better integrity, concerning biological degradation, when stored in ambient temperature. For this reason they were used to the proficiency testing pilot program. Ten laboratories participated in the proficiency testing pilot study and the results were evaluated using the following tests: z-score, confidence ellipse and En numbers. This work demonstrates the capability of the laboratory to produce reference materials as well as to organize and conduct proficiency testing. (author)

  20. 37 CFR 2.201 - Copies and certified copies.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Copies and certified copies... Trademark Office § 2.201 Copies and certified copies. (a) Non-certified copies of trademark registrations... appropriate fee required by § 2.6. (b) Certified copies of trademark registrations and of any...

  1. 7 CFR 201.69 - Classes of certified seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Classes of certified seed. 201.69 Section 201.69..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.69 Classes of certified seed. (a) Classes of certified seed are as...

  2. 7 CFR 945.7 - Certified seed potatoes.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Certified seed potatoes. 945.7 Section 945.7... Certified seed potatoes. Certified seed potatoes means and includes all potatoes officially certified and tagged, marked, or otherwise appropriately identified, under the supervision of the official seed...

  3. Improved efficiency of extraction of polycyclic aromatic hydrocarbons (PAHs) from the National Institute of Standards and Technology (NIST) Standard Reference Material Diesel Particulate Matter (SRM 2975) using accelerated solvent extraction.

    Science.gov (United States)

    Masala, Silvia; Ahmed, Trifa; Bergvall, Christoffer; Westerholm, Roger

    2011-12-01

    The efficiency of extraction of polycyclic aromatic hydrocarbons (PAHs) with molecular masses of 252, 276, 278, 300, and 302 Da from standard reference material diesel particulate matter (SRM 2975) has been investigated using accelerated solvent extraction (ASE) with dichloromethane, toluene, methanol, and mixtures of toluene and methanol. Extraction of SRM 2975 using toluene/methanol (9:1, v/v) at maximum instrumental settings (200 °C, 20.7 MPa, and five extraction cycles) with 30-min extraction times resulted in the following elevations of the measured concentration when compared with the certified and reference concentrations reported by the National Institute of Standards and Technology (NIST): benzo[b]fluoranthene, 46%; benzo[k]fluoranthene, 137%; benzo[e]pyrene, 103%; benzo[a]pyrene, 1,570%; perylene, 37%; indeno[1,2,3-cd]pyrene, 41%; benzo[ghi]perylene, 163%; and coronene, 361%. The concentrations of the following PAHs were comparable to the reference values assigned by NIST: indeno[1,2,3-cd]fluoranthene, dibenz[a,h]anthracene, and picene. The measured concentration of dibenzo[a,e]-pyrene was lower than the information value reported by the NIST. The measured concentrations of other highly carcinogenic PAHs (dibenzo[a,l]pyrene, dibenzo[a,i]pyrene, and dibenzo[a,h]pyrene) in SRM 2975 are also reported. Comparison of measurements using the optimized ASE method and using similar conditions to those applied by the NIST for the assignment of PAH concentrations in SRM 2975 indicated that the higher values obtained in the present study were associated with more complete extraction of PAHs from the diesel particulate material. Re-extraction of the particulate samples demonstrated that the deuterated internal standards were more readily recovered than the native PAHs, which may explain the lower values reported by the NIST. The analytical results obtained in the study demonstrated that the efficient extraction of PAHs from SRM 2975 is a critical requirement for the

  4. An investigation of safety climate in OHSAS 18001-certified and non-certified organizations.

    Science.gov (United States)

    Ghahramani, Abolfazl

    2016-09-01

    Many organizations worldwide have implemented Occupational Health and Safety Assessment Series (OHSAS) 18001 in their premises because of the assumed positive effects of this standard on safety. Few studies have analyzed the effect of the safety climate in OHSAS 18001-certified organizations. This case-control study used a new safety climate questionnaire to evaluate three OHSAS 18001-certified and three non-certified manufacturing companies in Iran. Hierarchical regression indicated that the safety climate was influenced by OHSAS implementation and by safety training. Employees who received safety training had better perceptions of the safety climate and its dimensions than other respondents within the certified companies. This study found that the implementation of OHSAS 18001 does not guarantee improvement of the safety climate. This study also emphasizes the need for high-quality safety training for employees of the certified companies to improve the safety climate. PMID:27108658

  5. Solid phase speciation of arsenic by sequential extraction in standard reference materials and industrially contaminated soil samples

    Energy Technology Data Exchange (ETDEWEB)

    Herreweghe, Samuel van; Swennen, Rudy; Vandecasteele, Carlo; Cappuyns, Valerie

    2003-04-01

    Leaching experiments, a mineralogical survey and larger samples are preferred when arsenic is present as discrete mineral phases. - Availability, mobility, (phyto)toxicity and potential risk of contaminants is strongly affected by the manner of appearance of elements, the so-called speciation. Operational fractionation methods like sequential extractions have been applied for a long time to determine the solid phase speciation of heavy metals since direct determination of specific chemical compounds can not always be easily achieved. The three-step sequential extraction scheme recommended by the BCR and two extraction schemes based on the phosphorus-like protocol proposed by Manful (1992, Occurrence and Ecochemical Behaviours of Arsenic in a Goldsmelter Impacted Area in Ghana, PhD dissertation, at the RUG) were applied to four standard reference materials (SRM) and to a batch of samples from industrially contaminated sites, heavily contaminated with arsenic and heavy metals. The SRM 2710 (Montana soil) was found to be the most useful reference material for metal (Mn, Cu, Zn, As, Cd and Pb) fractionation using the BCR sequential extraction procedure. Two sequential extraction schemes were developed and compared for arsenic with the aim to establish a better fractionation and recovery rate than the BCR-scheme for this element in the SRM samples. The major part of arsenic was released from the heavily contaminated samples after NaOH-extraction. Inferior extraction variability and recovery in the heavily contaminated samples compared to SRMs could be mainly contributed to subsample heterogeneity.

  6. Solid phase speciation of arsenic by sequential extraction in standard reference materials and industrially contaminated soil samples

    International Nuclear Information System (INIS)

    Leaching experiments, a mineralogical survey and larger samples are preferred when arsenic is present as discrete mineral phases. - Availability, mobility, (phyto)toxicity and potential risk of contaminants is strongly affected by the manner of appearance of elements, the so-called speciation. Operational fractionation methods like sequential extractions have been applied for a long time to determine the solid phase speciation of heavy metals since direct determination of specific chemical compounds can not always be easily achieved. The three-step sequential extraction scheme recommended by the BCR and two extraction schemes based on the phosphorus-like protocol proposed by Manful (1992, Occurrence and Ecochemical Behaviours of Arsenic in a Goldsmelter Impacted Area in Ghana, PhD dissertation, at the RUG) were applied to four standard reference materials (SRM) and to a batch of samples from industrially contaminated sites, heavily contaminated with arsenic and heavy metals. The SRM 2710 (Montana soil) was found to be the most useful reference material for metal (Mn, Cu, Zn, As, Cd and Pb) fractionation using the BCR sequential extraction procedure. Two sequential extraction schemes were developed and compared for arsenic with the aim to establish a better fractionation and recovery rate than the BCR-scheme for this element in the SRM samples. The major part of arsenic was released from the heavily contaminated samples after NaOH-extraction. Inferior extraction variability and recovery in the heavily contaminated samples compared to SRMs could be mainly contributed to subsample heterogeneity

  7. Production and characterization of APAT-RM004 (compost) and APAT-RM005 (agricultural soil) matrix reference materials

    International Nuclear Information System (INIS)

    Compost is the decomposed remnants of organic materials (usually those with plant origins) and it is used in gardening and agriculture, mixed in with the soil. It improves soil structure, increases the amount of organic matter, and provides nutrients. Compost is a common name for humus, which is the result of the decomposition of organic matter. Generally, compost is the raw material obtained by the aerobic decomposition of the organic residues of the municipal waste or of the vegetable market waste. Composting is the industrial operation to produce compost on a large scale and it is the controlled decomposition technique of organic matter. Rather than allowing nature to take its slow course, a composter provides an optimal environment in which decomposer can thrive. The compost raw material used to prepare the APAT-RM004 reference material has been obtained from an aerobic composting plant located near Rome (Italy). This plant produces compost from organic waste originating from municipal routine plant trimmings, pruning, lawn mowing and wastes deriving from vegetable markets. The homogeneity test was carried out on 10 different units (bottles) sequentially selected over the whole bottling process. This study has been carried by measuring the total contents of C by CHN-S considering a sample intake of 0.02g and by the determination of the Hg content by direct mercury analyzer (DMA-80) considering a sample intake of 0.5g. Both techniques achieve high precision levels and require little or no sample processing prior to analysis

  8. Nonparametric decision tree: The impact of ISO 9000 on certified and non certified companies

    Directory of Open Access Journals (Sweden)

    José António Figueiredo Almaça

    2013-09-01

    Full Text Available Purpose: This empirical study analyzes a questionnaire answered by a sample of ISO 9000 certified companies and a control sample of companies which have not been certified, using a multivariate predictive model. With this approach, we assess which quality practices are associated to the likelihood of the firm being certified. Design/methodology/approach: We implemented nonparametric decision trees, in order to see which variables influence more the fact that the company be certified or not, i.e., the motivations that lead companies to make sure. Findings: The results show that only four questionnaire items are sufficient to predict if a firm is certified or not. It is shown that companies in which the respondent manifests greater concern with respect to customers relations; motivations of the employees and strategic planning have higher likelihood of being certified. Research implications: the reader should note that this study is based on data from a single country and, of course, these results capture many idiosyncrasies if its economic and corporate environment. It would be of interest to understand if this type of analysis reveals some regularities across different countries. Practical implications: companies should look for a set of practices congruent with total quality management and ISO 9000 certified. Originality/value: This study contributes to the literature on the internal motivation of companies to achieve certification under the ISO 9000 standard, by performing a comparative analysis of questionnaires answered by a sample of certified companies and a control sample of companies which have not been certified. In particular, we assess how the manager’s perception on the intensity in which quality practices are deployed in their firms is associated to the likelihood of the firm being certified.

  9. Evaluation of new geological reference materials for uranium-series measurements: Chinese Geological Standard Glasses (CGSG) and macusanite obsidian.

    Science.gov (United States)

    Denton, J S; Murrell, M T; Goldstein, S J; Nunn, A J; Amato, R S; Hinrichs, K A

    2013-10-15

    Recent advances in high-resolution, rapid, in situ microanalytical techniques present numerous opportunities for the analytical community, provided accurately characterized reference materials are available. Here, we present multicollector thermal ionization mass spectrometry (MC-TIMS) and multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS) uranium and thorium concentration and isotopic data obtained by isotope dilution for a suite of newly available Chinese Geological Standard Glasses (CGSG) designed for microanalysis. These glasses exhibit a range of compositions including basalt, syenite, andesite, and a soil. Uranium concentrations for these glasses range from ∼2 to 14 μg g(-1), Th/U weight ratios range from ∼4 to 6, (234)U/(238)U activity ratios range from 0.93 to 1.02, and (230)Th/(238)U activity ratios range from 0.98 to 1.12. Uranium and thorium concentration and isotopic data are also presented for a rhyolitic obsidian from Macusani, SE Peru (macusanite). This glass can also be used as a rhyolitic reference material, has a very low Th/U weight ratio (around 0.077), and is approximately in (238)U-(234)U-(230)Th secular equilibrium. The U-Th concentration data agree with but are significantly more precise than those previously measured. U-Th concentration and isotopic data agree within estimated errors for the two measurement techniques, providing validation of the two methods. The large (238)U-(234)U-(230)Th disequilibria for some of the glasses, along with the wide range in their chemical compositions and Th/U ratios should provide useful reference points for the U-series analytical community. PMID:24004454

  10. Industrial-Strength Formally Certified SAT Solving

    CERN Document Server

    Darbari, Ashish; Marques-Silva, Joao

    2009-01-01

    Boolean Satisfiability (SAT) solvers are now routinely used in the verification of large industrial problems. However, their application in safety-critical domains such as the railways, avionics, and automotive industries requires some form of assurance for the results, as the solvers can (and sometimes do) have bugs. Unfortunately, the complexity of modern, highly optimized SAT solvers renders impractical the development of direct formal proofs of their correctness. This paper presents an alternative approach where an untrusted, industrial-strength, SAT solver is plugged into a trusted, formally certified, SAT proof checker to provide industrial-strength certified SAT solving. The key novelties and characteristics of our approach are (i) that the checker is automatically extracted from the formal development, (ii), that the combined system can be used as a standalone executable program independent of any supporting theorem prover, and (iii) that the checker certifies any SAT solver respecting the agreed form...

  11. 31 CFR 341.14 - Certifying officers.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Certifying officers. 341.14 Section 341.14 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... imprint of the corporate seal, or, where the institution is an authorized issuing agent for United...

  12. 31 CFR 346.14 - Certifying officers.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Certifying officers. 346.14 Section 346.14 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... imprint of the corporate seal, or, where the institution is an authorized issuing agent for United...

  13. 31 CFR 357.31 - Certifying individuals.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Certifying individuals. 357.31 Section 357.31 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... institutions, corporate central credit unions, and institutions that are members of...

  14. 31 CFR 306.45 - Certifying individuals.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Certifying individuals. 306.45 Section 306.45 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... employees of depository institutions, corporate central credit unions, and institutions that are members...

  15. Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: II. Performance of a laboratory network running the HPLC candidate reference measurement procedure and evaluation of a candidate reference material.

    Science.gov (United States)

    Helander, Anders; Wielders, Jos P M; Jeppsson, Jan-Olof; Weykamp, Cas; Siebelder, Carla; Anton, Raymond F; Schellenberg, François; Whitfield, John B

    2010-11-01

    Carbohydrate-deficient transferrin (CDT) is a descriptive term used for a temporary change in the transferrin glycosylation profile caused by alcohol, and used as a biomarker of chronic high alcohol consumption. The use of an array of methods for measurement of CDT in various absolute or relative amounts, and sometimes covering different transferrin glycoforms, has complicated the comparability of results and caused confusion among medical staff. This situation prompted initiation of an IFCC Working Group on CDT standardization. This second publication of the WG-CDT covers the establishment of a network of reference laboratories running a high-performance liquid chromatography (HPLC) candidate reference measurement procedure, and evaluation of candidate secondary reference materials. The network laboratories demonstrated good and reproducible performance and thus can be used to assign target values for calibrators and controls. A candidate secondary reference material based on native human serum lyophilized with a cryo-/lyoprotectant to prevent protein denaturation was found to be commutable and stable during storage. A proposed strategy for calibration of different CDT methods is also presented. In an external quality assurance study involving 66 laboratories and covering the current routine CDT assays (HPLC, capillary electrophoresis and immunoassay), recalculation of observed results based on the nominal values for the candidate calibrator reduced the overall coefficient of variation from 18.9% to 5.5%. The logistics for distribution of reference materials and review of results were found to be functional, indicating that a full reference system for CDT may soon be available.

  16. DIRECT DETERMINATION OF GOLD IN SUSPENSIONS OF ROCK AND ORE REFERENCE MATERIALS USING ELECTROTHERMAL HIGH RESOLUTION ATOMIC ABSORPTION SPECTROMETRY

    OpenAIRE

    Zakharov, Y. А.; Irisov, D. S.; Okunev, R. V.; Musin, R. Kh.; Haibullin, R. R.

    2014-01-01

    High resolution continuum source atomic absorption spectrometer ContrAA-700 with graphite furnace is used for direct gold determination in rocks and ores on the level 10-6-10-3 % mas. Russian standard reference materials of gold containing ore СЗР-4 (2.13 ± 0.05 g/ton), black slates of Sykhoy Log СЛг-1 (2.50 ± 0.03 g/ton) and СЧС-1 (0.10 ± 0.02 g/ton) in mass 1 mg was inserted into the furnace in the suspension form prepared on the mix of concentrated HNO3 and HCl (1:3) with following sevenfo...

  17. Upper Air Reference Materials

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Instructions for observing and recording radiosonde, pilot balloon and other in-situ observations above the earth's surface. Includes Weather Bureau Circular O.

  18. Marine Reference Materials

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Various publications and other instructions for taking marine weather observations. includes Weather Service Observing Handbook No. 1, Weather Bureau Circular M,...

  19. Desenvolvimento de material de referência para microbiologia de alimentos contendo estafilococos coagulase positiva em matriz queijo Development of reference material for the microbiology of foods containing coagulase-positive Staphylococcus in a cheese matrix

    Directory of Open Access Journals (Sweden)

    Marcelo Luiz Lima Brandão

    2013-03-01

    Full Text Available O uso de materiais de referência (MR é uma das principais ferramentas utilizadas para garantia e controle da qualidade de laboratórios de microbiologia de alimentos. No Brasil, a RDC n.º 12/01 da Anvisa prevê como um dos parâmetros para a avaliação da qualidade de queijos a enumeração de estafilococos coagulase positiva (ECP. O grande desafio na produção de MR destinados a ensaios microbiológicos é a instabilidade natural dos micro-organismos, o que dificulta o desenvolvimento e a manutenção desses MR. O objetivo deste estudo foi produzir um MR quantitativo destinado ao ensaio de enumeração de ECP em matriz queijo. Uma amostra de queijo ultrafiltrado com contagem de ECP The use of reference materials (RM is one of the principal tools used for assurance and quality control in food microbiology laboratories. In Brazil, Anvisa RDC nº 12/01 specifies the enumeration of coagulase-positive staphylococcus (CPS as one of the parameters for evaluating cheese quality. The main challenge in the production of RM destined for microbiological assays is the natural instability of the microorganisms, which makes it difficult to develop and maintain them. This study aimed to produce a quantitative RM for use in enumeration assays of CPS in cheese matrixes. A sample of an ultra-filtered cheese with a CPS count of <10 CFU/g and a total nº of viable aerobes of 1.2 × 10³ CFU/g was used as the matrix to produce the RM. The matrix was distributed in flasks, contaminated with specific concentrations of the target bacteria and submitted to freeze-drying. Sucrose was used as the cryo-protector. The RM produced was considered homogeneous and stable at < -70ºC during the entire study period (10 months. The material was shown to be stable at 4, 25, 30 and 35 ºC for 4 days, although the results indicated a decrease in cell concentration at 35 ºC. At -20 ºC the RM was stable for 48 days. It was concluded that the material showed all the necessary

  20. Establishment of a standard reference material (SRM) herbal DNA barcode library of Vitex negundo L. (lagundi) for quality control measures.

    Science.gov (United States)

    Olivar, Jay Edneil C; Alaba, Joanner Paulus Erik P; Atienza, Jose Francisco M; Tan, Jerick Jeffrey S; Umali, Maximo T; Alejandro, Grecebio Jonathan D

    2016-05-01

    The majority of the population in the Philippines relies on herbal products as their primary source for their healthcare needs. After the recognition of Vitex negundo L. (lagundi) as an important and effective alternative medicine for cough, sore throat, asthma and fever by the Philippine Department of Health (DOH), there was an increase in the production of lagundi-based herbal products in the form of teas, capsules and syrups. The efficiency of these products is greatly reliant on the use of authentic plant material, and to this day no standard protocol has been established to authenticate plant materials. DNA barcoding offers a quick and reliable species authentication tool, but its application to plant material has been less successful due to (1) lack of a standard DNA barcoding loci in plants and (2) poor DNA yield from powderised plant products. This study reports the successful application of DNA barcoding in the authentication of five V. negundo herbal products sold in the Philippines. Also, the first standard reference material (SRM) herbal library for the recognition of authentic V. negundo samples was established using 42 gene accessions of ITS, psbA-trnH and matK barcoding loci. Authentication of the herbal products utilised the SRM following the BLASTn and maximum-likelihood (ML) tree construction criterion. Barcode sequences were retrieved for ITS and psbA-trnH of all products tested and the results of the study revealed that only one out of five herbal products satisfied both BLASTn and ML criterion and was considered to contain authentic V. negundo. The results prompt the urgent need to utilise DNA barcoding in authenticating herbal products available in the Philippine market. Authentication of these products will secure consumer health by preventing the negative effects of adulteration, substitution and contamination. PMID:26982211

  1. Vattenfall Generation's Certified Environmental Product Declaration of Electricity from Ringhals AB

    International Nuclear Information System (INIS)

    This constitutes the certified Environmental Product Declaration (EPD) of electricity from the nuclear power plant at Ringhals commissioned by Vattenfall AB. The nuclear power plant at Ringhals is a base-load plant of the Swedish electricity system and is tuned to the consumption of electricity, running at maximum power output during the cold part of the year and at reduced power during the summer. As the concept of Life Cycle Assessments (LCA) evolves, certified EPDs have been established as a prime vehicle for industry in the communication of environmental impact to professional procurers. This is an EPD in accordance with the system administered by the Swedish Environmental Management Council (http://www.environdec.com). EPD is the Swedish application of ISO TR 14025, Type III environmental declarations. This EPD contains certifiable sections in accordance with rules and regulations. In addition a voluntary, partly qualitative, partly quantitative, and verifiable description of environmental impact is presented. Assessment of impact on biodiversity is specifically included, based on a method called The Biotope Method developed by Vattenfall. The method is continually being developed and is suited for quantitative assessment of the impact from land-use on biodiversity. A previous version of the method was first applied in the EPD for hydropower electricity from the Lule River in 1998, and for the EPD for electricity from the FKA nuclear power plant in 2000. There are also sections on safety, barriers, risks, and radiation as well as precautions against proliferation of weapons grade material, all of which are areas that our customers consider important. The declared product is 1 kWh net (the functional unit) delivered to the national grid during the reference year 1999. The nuclear power plant comprises one boiling-water reactor (BWR), Ringhals 1, and three pressurized-water reactors (PWR), Ringhals 2, 3, and 4 - all four reactors are light water reactors (LWR

  2. Characterisation of Leather Candidate Certified Reference Materials for their Mass Fractions of Aromatic Amines%用于分析皮革样本中芳香胺含量的检定标准物质的表征(续)

    Institute of Scientific and Technical Information of China (English)

    Jan-Willem Wegener; Haiko Schulz; 龚英

    2011-01-01

    Three batches of leather samples were colored with nine azo dyes that can yield eight proven or suspected carcinogenic aromatic amines under reduction conditions.The samples were milled to grains and bottled in jars.A group of five laboratories has established the mass fraction of the amines in a ring test using different analytical methods.The methods included a reduction step in order to cleave the azo dyes into the aromatic amines.Quantification was by standard addition: sub - samples of the leathers were spiked with known amounts of azo dyes of known purity.It was possible to establish the mass fractions of six of the eight aromatic amines in three of the leather samples.%用9种已经确认或被怀疑的在还原条件下将生成8种致癌芳香胺的染料,对3批皮革样品染色.将皮革样品切碎为颗粒后,装入到广口瓶中.由5个实验室组成的试验组,在环试验中采用不同方法分析这些芳香胺在皮革中所占的质量分数.这些分析方法均包括还原步骤,即,使偶氮染料裂解为芳香胺.采用向皮革子样本加入已知量的且已知纯度的偶氮染料这种标准加入法,进行定量分析.在这3批皮革样品中,可以对这8类芳香胺中的6种进行质量含量的分析.

  3. Chemical Bonding and Structural Information of Black CarbonReference Materials and Individual Carbonaceous AtmosphericAerosols

    Energy Technology Data Exchange (ETDEWEB)

    Hopkins, Rebecca J.; Tivanski, Alexei V.; Marten, Bryan D.; Gilles, Mary K.

    2007-04-25

    The carbon-to-oxygen ratios and graphitic nature of a rangeof black carbon standard reference materials (BC SRMs), high molecularmass humic-like substances (HULIS) and atmospheric particles are examinedusing scanning transmission X-ray microscopy (STXM) coupled with nearedge X-ray absorption fine structure (NEXAFS) spectroscopy. UsingSTXM/NEXAFS, individual particles with diameter>100 nm are studied,thus the diversity of atmospheric particles collected during a variety offield missions is assessed. Applying a semi-quantitative peak fittingmethod to the NEXAFS spectra enables a comparison of BC SRMs and HULIS toparticles originating from anthropogenic combustion and biomass burns,thus allowing determination of the suitability of these materials forrepresenting atmospheric particles. Anthropogenic combustion and biomassburn particles can be distinguished from one another using both chemicalbonding and structural ordering information. While anthropogeniccombustion particles are characterized by a high proportion ofaromatic-C, the presence of benzoquinone and are highly structurallyordered, biomass burn particles exhibit lower structural ordering, asmaller proportion of aromatic-C and contain a much higher proportion ofoxygenated functional groups.

  4. Application of reference point indentation for micro-mechanical surface characterization of calcium silicate based dental materials.

    Science.gov (United States)

    Antonijević, Djordje; Milovanović, Petar; Riedel, Christoph; Hahn, Michael; Amling, Michael; Busse, Björn; Djurić, Marija

    2016-04-01

    The objective of this study was to elucidate micromechanical properties of Biodentine and two experimental calcium silicate cements (CSCs) using Reference Point Indentation (RPI). Biomechanical characteristics of the cement type and the effects of a radiopacifier, liquid components, acid etching treatment and bioactivation in simulated body fluid (SBF) were investigated by measuring the microhardness, average unloading slope (Avg US) and indentation distance increase (IDI). Biodentine had a greater microhardness than the experimental CSCs, while the Avg US and IDI values were not significantly different among investigated materials. There was a statistically significant difference in microhardness and IDI values between pure CSCs and radiopacified cements (p < 0.05). Micromechanical properties were not affected by different liquid components used. Acid-etching treatment reduced Biodentine's microhardness while cements' immersion in SBF resulted in greater microhardness and higher IDI values compared to the control group. Clearly, the physiological environment and the cements' composition affect their surface micromechanical properties. The addition of calcium chloride and CSCs' immersion in SBF are beneficial for CSCs' micromechanical performance, while the addition of radiopacifiers and acid etching treatment weaken the CSCs' surface. Application of RPI aids with the characterization of micromechanical properties of synthetic materials' surfaces. PMID:26888441

  5. Strategies for building reference standards for autoantibodies

    Directory of Open Access Journals (Sweden)

    Joanna eSheldon

    2015-04-01

    Full Text Available Producing robust, certified, traceable reference material for autoantibody testing is a vital element in maintaining the validity of results that are generated in the daily clinical laboratory routine. This is a huge challenge because of the high number of variables involved in the detection and measurement of the autoantibodies. The production of such materials is time consuming and needs rigorous attention to detail; this is best achieved by an overarching independent body who will oversee the process in a not for profit manner.Much effort has been made to build international standards for quantitative and qualitative assays based on monoclonal antibodies, obtained from affinity purification and plasmapheresis. The big challenge is to respect individual differences in immune response to the same antigen. A promising ongoing initiative is the construction of pools with monospecific samples from different individuals.

  6. Nicotine, acetanilide and urea multi-level2H-,13C- and15N-abundance reference materials for continuous-flow isotope ratio mass spectrometry

    Science.gov (United States)

    Schimmelmann, A.; Albertino, A.; Sauer, P.E.; Qi, H.; Molinie, R.; Mesnard, F.

    2009-01-01

    Accurate determinations of stable isotope ratios require a calibration using at least two reference materials with different isotopic compositions to anchor the isotopic scale and compensate for differences in machine slope. Ideally, the S values of these reference materials should bracket the isotopic range of samples with unknown S values. While the practice of analyzing two isotopically distinct reference materials is common for water (VSMOW-SLAP) and carbonates (NBS 19 and L-SVEC), the lack of widely available organic reference materials with distinct isotopic composition has hindered the practice when analyzing organic materials by elemental analysis/isotope ratio mass spectrometry (EA-IRMS). At present only L-glutamic acids USGS40 and USGS41 satisfy these requirements for ??13C and ??13N, with the limitation that L-glutamic acid is not suitable for analysis by gas chromatography (GC). We describe the development and quality testing of (i) four nicotine laboratory reference materials for on-line (i.e. continuous flow) hydrogen reductive gas chromatography-isotope ratio mass-spectrometry (GC-IRMS), (ii) five nicotines for oxidative C, N gas chromatography-combustion-isotope ratio mass-spectrometry (GC-C-IRMS, or GC-IRMS), and (iii) also three acetanilide and three urea reference materials for on-line oxidative EA-IRMS for C and N. Isotopic off-line calibration against international stable isotope measurement standards at Indiana University adhered to the 'principle of identical treatment'. The new reference materials cover the following isotopic ranges: ??2Hnicotine -162 to -45%o, ??13Cnicotine -30.05 to +7.72%, ?? 15Nnicotine -6.03 to +33.62%; ??15N acetanilide +1-18 to +40.57%; ??13Curea -34.13 to +11.71%, ??15Nurea +0.26 to +40.61% (recommended ?? values refer to calibration with NBS 19, L-SVEC, IAEA-N-1, and IAEA-N-2). Nicotines fill a gap as the first organic nitrogen stable isotope reference materials for GC-IRMS that are available with different ??13N

  7. 7 CFR 205.662 - Noncompliance procedure for certified operations.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.662... of a certified operation by a certifying agent or a State organic program's governing State...

  8. 76 FR 19310 - Information Collection; Certified State Mediation Program

    Science.gov (United States)

    2011-04-07

    ... Farm Service Agency Information Collection; Certified State Mediation Program AGENCY: Farm Service... Mediation Program. The information collection is necessary to ensure the grant program is being administered... following methods: Mail: Carol Wagner, Certified State Mediation Program Manager, USDA, FSA, Appeals...

  9. Advances in the Metrology of Absolute Value Assignments to Isotopic Reference Materials: Consequences from the Avogadro Project

    Science.gov (United States)

    Vocke, Robert; Rabb, Savelas

    2015-04-01

    All isotope amount ratios (hereafter referred to as isotope ratios) produced and measured on any mass spectrometer are biased. This unfortunate situation results mainly from the physical processes in the source area where ions are produced. Because the ionized atoms in poly-isotopic elements have different masses, such processes are typically mass dependent and lead to what is commonly referred to as mass fractionation (for thermal ionization and electron impact sources) and mass bias (for inductively coupled plasma sources.) This biasing process produces a measured isotope ratio that is either larger or smaller than the "true" ratio in the sample. This has led to the development of numerous fractionation "laws" that seek to correct for these effects, many of which are not based on the physical processes giving rise to the biases. The search for tighter and reproducible precisions has led to two isotope ratio measurement systems that exist side-by-side. One still seeks to measure "absolute" isotope ratios while the other utilizes an artifact based measurement system called a delta-scale. The common element between these two measurement systems is the utilization of isotope reference materials (iRMs). These iRMs are used to validate a fractionation "law" in the former case and function as a scale anchor in the latter. Many value assignments of iRMs are based on "best measurements" by the original groups producing the reference material, a not entirely satisfactory approach. Other iRMs, with absolute isotope ratio values, have been produced by calibrated measurements following the Atomic Weight approach (AW) pioneered by NBS nearly 50 years ago. Unfortunately, the AW is not capable of calibrating the new generation of iRMs to sufficient precision. So how do we get iRMs with isotope ratios of sufficient precision and without bias? Such a focus is not to denigrate the extremely precise delta-scale measurements presently being made on non-traditional and tradition

  10. Synthesis of Precision for the Certification of Phosphorus in Biological Materials by INAA

    DEFF Research Database (Denmark)

    Damsgaard, E.; Heydorn, K.

    1987-01-01

    The β-emitter32P was used to determine total phosphorus by INAA in Skim Milk Powder RM 63, a material now certified by the EEC Bureau of Reference (BCR). Samples and comparator were irradiated in the Danish reactor DR 3. One month later the samples were dissolved in water and aliquots counted...

  11. 19 CFR 159.35 - Certified daily rate.

    Science.gov (United States)

    2010-04-01

    ... TREASURY (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.35 Certified daily rate... the conversion of foreign currency whenever a proclaimed rate or certified quarterly rate is not... 19 Customs Duties 2 2010-04-01 2010-04-01 false Certified daily rate. 159.35 Section...

  12. 19 CFR 159.34 - Certified quarterly rate.

    Science.gov (United States)

    2010-04-01

    ... TREASURY (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.34 Certified quarterly rate. (a) Countries for which quarterly rate is certified. For the currency of each of the following... 19 Customs Duties 2 2010-04-01 2010-04-01 false Certified quarterly rate. 159.34 Section...

  13. 37 CFR 1.13 - Copies and certified copies.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Copies and certified copies... Patent and Trademark Office § 1.13 Copies and certified copies. (a) Non-certified copies of patents, and... States Patent and Trademark Office to any person, and copies of other records or papers will be...

  14. 33 CFR 159.17 - Changes to certified devices.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Changes to certified devices. 159... (CONTINUED) POLLUTION MARINE SANITATION DEVICES Certification Procedures § 159.17 Changes to certified devices. (a) The manufacturer of a device that is certified under this part shall notify the...

  15. Choosing optimal exposure times for XRF core-scanning: Suggestions based on the analysis of geological reference materials

    Science.gov (United States)

    Huang, Jyh-Jaan; Löwemark, Ludvig; Chang, Queenie; Lin, Tzu-Yu; Chen, Huei-Fen; Song, Sheng-Rong; Wei, Kuo-Yen

    2016-04-01

    X-ray fluorescence (XRF) core-scanning is a fast and nondestructive technique to assess elemental variations of unprocessed sediments. However, although the exposure time of XRF-scanning directly affects the scanning counts and total measurement time, only a few studies have considered the influence of exposure time during the scan. How to select an optimal exposure time to achieve reliable results and reduce the total measurement time is an important issue. To address this question, six geological reference materials from the Geological Survey of Japan (JLK-1, JMS-1, JMS-2, JSD-1, JSD-2, and JSD-3) were scanned by the Itrax-XRF core scanner using the Mo- and the Cr-tube with different exposure times to allow a comparison of scanning counts with absolute concentrations. The regression lines and correlation coefficients of elements that are generally used in paleoenvironmental studies were examined for the different exposure times and X-ray tubes. The results show that for those elements with relatively high concentrations or high detectability, the correlation coefficients are higher than 0.90 for all exposure times. In contrast, for the low detectability or low concentration elements, the correlation coefficients are relatively low, and improve little with increased exposure time. Therefore, we suggest that the influence of different exposure times is insignificant for the accuracy of the measurements. Thus, caution must be taken when interpreting the results of elements with low detectability, even when the exposure times are long and scanning counts are reasonably high.

  16. Research on Development Methods of Sensory Reference Materials of Agricultural Products%农产品感官类标准样品研制方法研究

    Institute of Scientific and Technical Information of China (English)

    席兴军; 郑振佳; 潘红玫

    2014-01-01

    感官类标准样品是标准样品的一大类,是农产品分等定级和定性判定的基础性物质。但目前感官标准样品特别是农产品感官标准样品与理化标准样品的研制存在较大差别,难以采用现有标准样品的定值方法和理论进行感官标准样品的量值,也很难实现重复性和复现性。因此,研究农产品感官类标准样品研制方法将对具有量值和溯源性的烟草、茶叶、珍珠、小麦、棉花等标准样品的研制,确保农产品感官类特性评价在不同时间和空间获得一致性的结果具有重要的意义。%Sensory reference material is the basic substancein classification,gradation and qualitative judgmentof agricultural products, which is an important class of standards.There are many differences in research between sensoryreference materials and chemicalreference materials, especially sensory reference materials of agricultural products.Meanwhile,the certification of sensory reference materials with existing methods and theorywould be difficult to achieverepeatability and reproducibility of the result.Research on development methods of sensory reference material of agricultural productscould provide references forthe preparation of some reference materials with magnitude and traceability which like tobacco, tea, pearl, wheat, cotton, as so on.Moreover, it is meaningful for the assurance ofthe sensory characteristic evaluation of agricultural products to get the consistencyresultsindifferent time and space.

  17. Research on Development Methods of Sensory Reference Materials of Agricultural Products%农产品感官类标准样品研制方法研究

    Institute of Scientific and Technical Information of China (English)

    席兴军; 郑振佳; 潘红玫

    2013-01-01

    感官类标准样品是标准样品的一大类,是农产品分等定级和定性判定的基础性物质.但目前感官标准样品特别是农产品感官标准样品与理化标准样品的研制存在较大差别,难以采用现有标准样品的定值方法和理论进行感官标准样品的量值,也很难实现重复性和复现性.因此,研究农产品感官类标准样品研制方法将对具有量值和溯源性的烟草、茶叶、珍珠、小麦、棉花等标准样品的研制,确保农产品感官类特性评价在不同时间和空间获得一致性的结果具有重要的意义.%Sensory reference material is the basic substancein classification,gradation and qualitative judgmentof agricultural products, which is an important class of standards.There are many differences in research between sensoryreference materials and chemicalreference materials, especially sensory reference materials of agricultural products.Meanwhile,the certification of sensory reference materials with existing methods and theorywould be difficult to achieverepeatability and reproducibility of the result.Research on development methods of sensory reference material of agricultural productscould provide references forthe preparation of some reference materials with magnitude and traceability which like tobacco, tea, pearl, wheat, cotton, as so on.Moreover, it is meaningful for the assurance ofthe sensory characteristic evaluation of agricultural products to get the consistencyresultsindifferent time and space.

  18. Application of new reference materials for the quality control of water; Aplicaciones de nuevos materiales de referencia microbiologicos al control de la calidad del agua

    Energy Technology Data Exchange (ETDEWEB)

    Yanez, A.; Soria, E.; Murtula, R.; Catalan, V.

    2007-07-01

    In laboratories dedicated to the quality control of water, as it occurs in the rest of assay laboratories, it is important to guarantee de validity and traceability of the generated results, and for this reason there is an increasing interest in introducing standards such as UNE-EN ISO/ICI 17025. Therefore, it is important and necessary the use of reference materials for different purposes, such as methods validation or the performance of actions based on the systematic contrast of all the activities involves in the quality control. Nevertheless, in microbiology the present offer of reference materials in very low mainly because they are very difficult to be prepared, and for this reason in this work we show our experience in the development of a new microbiological quantitative reference material, that will improve the use of microbial strains in the assay laboratories. (Author)

  19. Governing "Eco-Certified Children" through Pastoral Power: Critical Perspectives on Education for Sustainable Development

    Science.gov (United States)

    Ideland, Malin; Malmberg, Claes

    2015-01-01

    This article analyses how "eco-certified children" are constructed as desirable subjects in teaching materials addressing education for sustainable development. We are interested in how discourses structure this cherished practice and how this practice has become "natural" and obvious for us. A discourse analysis is carried out…

  20. Desenvolvimento de material de referência para microbiologia de alimentos contendo Listeria monocytogenes em matriz queijo

    Directory of Open Access Journals (Sweden)

    Marcelo Luiz Lima Brandão

    2013-10-01

    Full Text Available A NBR ISO/IEC 17025:2005, uma das normas mais utilizadas em laboratórios de ensaio, descreve como um de seus critérios para a garantia da qualidade dos resultados analíticos a participação periódica dos laboratórios em ensaios de proficiência (EP. Os analitos, utilizados nos EP são materiais de referência (MR provenientes de um mesmo lote, e devem apresentar características de homogeneidade e estabilidade. O objetivo deste estudo foi produzir um MR qualitativo destinado ao ensaio de pesquisa de Listeria monocytogenes em matriz queijo pela técnica de liofilização. Para a produção do MR, foi utilizado como matriz o queijo Minas frescal (QMF ultrafiltrado. A matriz foi distribuída em frascos, contaminada com a bactéria alvo e submetida à liofilização, tendo a sacarose como crioprotetor. O MR produzido foi considerado homogêneo e estável na temperatura de ≤-70°C durante todo o período estudado (10 meses. O material apresentou estabilidade a 4, 25, 30 e 35°C por quatro dias e a -20°C por 48 dias, e os resultados estatísticos indicam tendência à estabilidade. Conclui-se que o material apresentou todos os requisitos necessários de um MR de qualidade e poderia ser transportado aos laboratórios participantes de um EP à temperatura máxima de 35°C por até quatro dias, uma vez que os resultados indicaram a manutenção da concentração celular nesse período. Esse foi o primeiro trabalho a descrever uma metodologia de produção de MR contendo L. monocytogenes em matriz queijo.

  1. Value Assignment of Isotopic Reference Materials - Approaches, Pitfalls and Workarounds based on Experiences from the Avogadro Project

    Science.gov (United States)

    Vocke, R.; Rabb, S.; Mann, J.

    2012-04-01

    Isotope ratio measurements and their application to the natural world have undergone profound changes in the past decade. These changes have arisen due to improvements in measurement precision by modern multi-collector instrumentation and also the maturation of powerful ionization sources, specifically those employing inductively coupled plasma (ICP) torches. The latter development has made the entire periodic table a fertile hunting ground for small but significant natural isotopic variations produced by new and novel processes as well as the older and well studied mechanisms. Unfortunately, Isotopic Reference Material (IRM) production by National Metrology Institutes (NMI) has not kept up this these advances. This has necessitated the production and value assignment of working IRMs by the researchers pioneering these advances. This sort of distribution and characterization system leads to problems with long-term availability to the research community as the pioneers move onto other elements and isotopic systems, losing interest in the "old" when tempted by "new" and therefore fundable research opportunities. Furthermore, most value assignments of such IRMs are based on "best measurements" by the original groups and thus represent mass discrimination dependent models of the materials' isotopic signature, a situation that often leads to a proliferation of different values depending on research group or philosophy, a highly confusing and potentially non-constructive situation! We have been working closely with other NMIs (PTB, NRC and NIM) to produce accurate molar mass determinations of the highly pure 28Si being used in the Avogadro Project (an international effort to replace the original kilogram artifact with a procedure and measurement protocol that any technologically advanced nation can use to realize this fundamental SI unit). The basis for the approach was conceived and developed at the PTB (e.g. [1]). Its applicability to accurate and non

  2. A laboratory study on formation of oil-SPM aggregates using the NIST standard reference material 1941b. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Khelifa, A.; Fieldhouse, B.; Wang, Z.; Yang, C.; Landriault, M.; Fingas, M.; Brown, C.E.; Gamble, L. [Environment Canada, Ottawa, ON (Canada). ; Pjontek, D. [Ottawa Univ., ON (Canada). Dept. of Chemical Engineering

    2007-07-01

    The dispersion of spilled oil in water can be enhanced by a natural process in which suspended particulate matter (SPM) combines with oil droplets to form Oil-SPM aggregates (OSA). A laboratory setup and procedure were developed in this study to examine the formation of OSAs in which the sediment (Standard Reference Material 1941b) was mixed with Arabian Medium, Alaska North Slope and South Louisiana crudes at concentrations varying from 25 to 300 mg/L. The OSAs were separated from the bulk water using a newly developed procedure. Gas chromatography combined with flame ionization analysis was used to measure the oil trapped in the OSAs. The sediment trapped in the sinking OSAs was then isolated for gravimetric quantification. This procedure has the potential to isolate sinking OSAs with minimum alteration with dispersed oil. Oil mass of less than 2 mg trapped in OSAs was measured with 0.8 mg uncertainty at a 95 per cent confidence level. This setup was capable of imaging droplets of 0.1 {mu}g and up in size. The study showed that formation of sinking OSAs reaches maximum efficiency at an optimum oil to sediment ratio that decreases from 0.5 to approximately 0.1 when the ratio between oil density and the water density increases from 0.84 to 0.97. The percentage of oil trapped in sinking OSAs increases quickly from approximately 0.5 per cent to 30 per cent of the initial oil mass when sediment concentration increases from 25 to 100 mg/l. The highest trapping efficiency was found to decrease exponentially with oil density. 33 refs., 2 tabs., 12 figs.

  3. A laboratory study on formation of oil-SPM aggregates using the NIST standard reference material 1941b

    Energy Technology Data Exchange (ETDEWEB)

    Khelifa, A.; Fieldhouse, B.; Wang, Z.; Yang, C.; Landriault, M.; Fingas, M.; Brown, C.E.; Gamble, L. [Environment Canada, Ottawa, ON (Canada). ; Pjontek, D. [Ottawa Univ., ON (Canada). Dept. of Chemical Engineering

    2007-07-01

    The dispersion of spilled oil in water can be enhanced by a natural process in which suspended particulate matter (SPM) combines with oil droplets to form Oil-SPM aggregates (OSA). A laboratory setup and procedure were developed in this study to examine the formation of OSAs in which the sediment (Standard Reference Material 1941b) was mixed with Arabian Medium, Alaska North Slope and South Louisiana crudes at concentrations varying from 25 to 300 mg/L. The OSAs were separated from the bulk water using a newly developed procedure. Gas chromatography combined with flame ionization analysis was used to measure the oil trapped in the OSAs. The sediment trapped in the sinking OSAs was then isolated for gravimetric quantification. This procedure has the potential to isolate sinking OSAs with minimum alteration with dispersed oil. Oil mass of less than 2 mg trapped in OSAs was measured with 0.8 mg uncertainty at a 95 per cent confidence level. This setup was capable of imaging droplets of 0.1 {mu}g and up in size. The study showed that formation of sinking OSAs reaches maximum efficiency at an optimum oil to sediment ratio that decreases from 0.5 to approximately 0.1 when the ratio between oil density and the water density increases from 0.84 to 0.97. The percentage of oil trapped in sinking OSAs increases quickly from approximately 0.5 per cent to 30 per cent of the initial oil mass when sediment concentration increases from 25 to 100 mg/l. The highest trapping efficiency was found to decrease exponentially with oil density. 33 refs., 2 tabs., 12 figs.

  4. CISA Certified Information Systems Auditor : study guide

    CERN Document Server

    Cannon, David L

    2011-01-01

    The industry-leading study guide for the CISA exam, fully updated. More than 27,000 IT professionals take the Certified Information Systems Auditor exam each year. SC Magazine lists the CISA as the top certification for security professionals. Compliances, regulations, and best practices for IS auditing are updated twice a year, and this is the most up-to-date book available to prepare aspiring CISAs for the next exam.: CISAs are among the five highest-paid IT security professionals; more than 27,000 take the exam each year and the numbers are growing; Standards are updated twice a year, and t

  5. Preparation of bovine muscle, bovine liver and pig kidney reference materials and the certification of the contents of nine elements of toxicological and nutritional interest

    International Nuclear Information System (INIS)

    The preparation of 3 meat reference materials (bovine muscle, bovine liver and pig kidney) and the steps taken to confirm their homogeneity and stability are described. Details are presented of a preliminary intercomparison and of the final collaborative exercise which led to the certification of the contents of 9 elements of toxicological and nutritional importance. Indicative values are given for the contents of a further 9 elements in these materials. (orig.)

  6. 77 FR 5415 - National Organic Program: Notice of Draft Guidance for Accredited Certifying Agents, Certified...

    Science.gov (United States)

    2012-02-03

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 205 National Organic Program: Notice of... Certified Organic Products AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice of availability with..., Agricultural Marketing Specialist, National Organic Program, USDA-AMS- NOP, 1400 Independence Ave. SW.,...

  7. Training and Certification Program for Certified Energy Auditors (CEA) and Certified Building Commissioning Professionals (CBCP)

    Energy Technology Data Exchange (ETDEWEB)

    Kent, Bill

    2012-08-24

    The Association of Energy Engineers (AEE) has offered energy efficiency training and certification programs for over 30 years. During that time AEE has certified more than 22,000 professionals. All of our certification programs are the result of extensive industry research and program development and oversight by certification boards. For this project award, AEE proposed to work with the Department of Energy to utilize and extend existing industry recognized Certified Energy Auditor (CEA) and Certified Building Commissioning Professional (CBCP) programs under this Training Program Development Announcement. These expanded training programs will have significant impact in training professionals for building commissioning and energy auditing to achieve the goal of bringing existing buildings up to their optimal energy performance potential and ensuring that new buildings maintain their expected optimal level of performance. The goals and objectives of the training development project were achieved with the development of new training programs that are now being offered as self-sustaining commercial training and certification programs. These new programs are training and certifying professionals who are accomplishing the goal of increasing building energy performance in both existing and new buildings.

  8. Comprehensive analysis for major, minor and trace element contents and Sr-Nd-Pb-Hf isotope ratios in sediment reference materials, JSd-1 and MAG-1

    Digital Repository Service at National Institute of Oceanography (India)

    Nath, B.N.; Makishima, A.; Noordmann, J.; Tanaka, R.; Nakamura, E.

    In view of the requirement of a well-characterized and easily available aquatic sediment reference material, a comprehensive analysis comprising of fifty major, minor and trace elements as well as Sr–Nd–Pb–Hf isotopes were carried out...

  9. Organic Reference Materials for Hydrogen, Carbon, and Nitrogen Stable Isotope-Ratio Measurements : Caffeines, n-Alkanes, Fatty Acid Methyl Esters, Glycines, L-Valines, Polyethylenes, and Oils

    NARCIS (Netherlands)

    Schimmelrnann, Arndt; Qi, Haiping; Coplen, Tyler B.; Brand, Willi A.; Fong, Jon; Meier-Augenstein, Wolfram; Kemp, Helen F.; Toman, Blaza; Ackermann, Annika; Assonov, Sergey; Aerts-Bijma, Anita T.; Brejcha, Ramona; Chikaraishi, Yoshito; Darwish, Tamim; Elsner, Martin; Gehre, Matthias; Geilmann, Heike; Groeing, Manfred; Helie, Jean-Francois; Herrero-Martin, Sara; Meijer, Harro A. J.; Sauer, Peter E.; Sessions, Alex L.; Werner, Roland A.

    2016-01-01

    An international project developed, quality-tested, and determined isotope-delta values of 19 new organic reference materials (RMs) for hydrogen, carbon, and nitrogen stable isotope-ratio measurements, in addition to analyzing pre-existing RMs NBS 22 (oil), IAEA-CH-7 (polyethylene foil), and IAEA-60

  10. Survey of Library and Information Problems in Correctional Institutions. Volume 2: Access to Legal Reference Materials in Correctional Institutions. ILR-73-009. Final Report.

    Science.gov (United States)

    LeDonne, Marjorie

    In order to discern states' compliance with court mandates to provide prisoners with adequate legal counsel or access to legal reference materials, a questionnaire was administered to state consultants in 1972 and updated and expanded by later contacts with institutional consultants. Findings indicated that states are trying to comply with…

  11. Comprehensive inter-laboratory calibration of reference materials for delta O-18 versus VSMOW using various on-line high-temperature conversion techniques

    NARCIS (Netherlands)

    Brand, Willi A.; Coplen, Tyler B.; Aerts-Bijma, Anita T.; Böhlke, J.K.; Gehre, Matthias; Geilmann, Heike; Gröning, Manfred; Jansen, Henk G.; Meijer, Harro A. J.; Mroczkowski, Stanley J.; Qi, Haiping; Soergel, Karin; Stuart-Williams, Hilary; Weise, Stephan M.; Werner, Roland A.

    2009-01-01

    Internationally distributed organic and inorganic oxygen isotopic reference materials have been calibrated by six laboratories carrying out more than 5300 measurements using a variety of high-temperature conversion techniques (HTC)a in an evaluation sponsored by the International Union of Pure and A

  12. Organizational Impacts due to ISO 9001 Certified Implementation on Brazilians Cardboard Companies

    OpenAIRE

    Glaucia Aparecida Prates; Jose Claudio Caraschi

    2014-01-01

    This paper presents the evaluation internal and external organizational impacts of a company that has adopted a total quality management system: ISO 9001 certification. Based on a case study, supported in bibliographic references in a cardboard sector company, the survey aims to measure and evaluate the basic concepts of quality and the certification benefits. Upon this study completion it was found that actually getting a certified ISO 9001 brings many organizational impacts and leads to ove...

  13. Determination of the absolute 32S/34S ratio of IAEA-S-1 reference material and V-CDT sulfur isotope standard

    Institute of Scientific and Technical Information of China (English)

    丁悌平; 白瑞梅; 李延河; 万德芳; 邹晓秋; 张青莲

    1999-01-01

    The absolute 32S/34S ratios of IAEA-S-1 reference material and V-CDT standard are determined. For cross-checking, two sets of synthetic isotope mixtures are prepared from high purity 32S and 34S-enriched materials in different forms: the first set is prepared from BaSO4 whereas the second is prepared from Ag2S. The sulfur isotope analyses are done by using SF6 method with a MAT-251 EM mass spectrometer. The resulting 32S/34S ratio of IAEAS-1 reference material is 22.656 4±0. 006 0, and that of V-CDT is 22. 649 6±0. 006 0.

  14. Certified metamodels for sensitivity indices estimation

    CERN Document Server

    Janon, Alexandre; Prieur, Clémentine

    2011-01-01

    Global sensitivity analysis of a numerical code, more specifically estimation of Sobol indices associated with input variables, generally requires a large number of model runs. When those demand too much computation time, it is necessary to use a reduced model (metamodel) to perform sensitivity analysis, whose outputs are numerically close to the ones of the original model, while being much faster to run. In this case, estimated indices are subject to two kind of errors: sampling error, caused by the computation of the integrals appearing in the definition of the Sobol indices by a Monte-Carlo method, and metamodel error, caused by the replacement of the original model by the metamodel. In cases where we have certified bounds for the metamodel error, we propose a method to quantify both types of error, and we compute confidence intervals for first-order Sobol indices.

  15. USGS42 and USGS43: Human-hair stable hydrogen and oxygen isotopic reference materials and analytical methods for forensic science and implications for published measurement results

    Science.gov (United States)

    Coplen, T.B.; Qi, H.

    2012-01-01

    Because there are no internationally distributed stable hydrogen and oxygen isotopic reference materials of human hair, the U.S. Geological Survey (USGS) has prepared two such materials, USGS42 and USGS43. These reference materials span values commonly encountered in human hair stable isotope analysis and are isotopically homogeneous at sample sizes larger than 0.2 mg. USGS42 and USGS43 human-hair isotopic reference materials are intended for calibration of δ(2)H and δ(18)O measurements of unknown human hair by quantifying (1) drift with time, (2) mass-dependent isotopic fractionation, and (3) isotope-ratio-scale contraction. While they are intended for measurements of the stable isotopes of hydrogen and oxygen, they also are suitable for measurements of the stable isotopes of carbon, nitrogen, and sulfur in human and mammalian hair. Preliminary isotopic compositions of the non-exchangeable fractions of these materials are USGS42(Tibetan hair)δ(2)H(VSMOW-SLAP) = -78.5 ± 2.3‰ (n = 62) and δ(18)O(VSMOW-SLAP) = +8.56 ± 0.10‰ (n = 18) USGS42(Indian hair)δ(2)H(VSMOW-SLAP) = -50.3 ± 2.8‰ (n = 64) and δ(18)O(VSMOW-SLAP) = +14.11 ± 0.10‰ (n = 18). Using recommended analytical protocols presented herein for δ(2)H(VSMOW-SLAP) and δ(18)O(VSMOW-SLAP) measurements, the least squares fit regression of 11 human hair reference materials is δ(2)H(VSMOW-SLAP) = 6.085δ(2)O(VSMOW-SLAP) - 136.0‰ with an R-square value of 0.95. The δ(2)H difference between the calibrated results of human hair in this investigation and a commonly accepted human-hair relationship is a remarkable 34‰. It is critical that readers pay attention to the δ(2)H(VSMOW-SLAP) and δ(18)O(VSMOW-SLAP) of isotopic reference materials in publications, and they need to adjust the δ(2)H(VSMOW-SLAP) and δ(18)O(VSMOW-SLAP) measurement results of human hair in previous publications, as needed, to ensure all results on are on the same scales.

  16. USGS42 and USGS43: human-hair stable hydrogen and oxygen isotopic reference materials and analytical methods for forensic science and implications for published measurement results.

    Science.gov (United States)

    Coplen, Tyler B; Qi, Haiping

    2012-01-10

    Because there are no internationally distributed stable hydrogen and oxygen isotopic reference materials of human hair, the U.S. Geological Survey (USGS) has prepared two such materials, USGS42 and USGS43. These reference materials span values commonly encountered in human hair stable isotope analysis and are isotopically homogeneous at sample sizes larger than 0.2 mg. USGS42 and USGS43 human-hair isotopic reference materials are intended for calibration of δ(2)H and δ(18)O measurements of unknown human hair by quantifying (1) drift with time, (2) mass-dependent isotopic fractionation, and (3) isotope-ratio-scale contraction. While they are intended for measurements of the stable isotopes of hydrogen and oxygen, they also are suitable for measurements of the stable isotopes of carbon, nitrogen, and sulfur in human and mammalian hair. Preliminary isotopic compositions of the non-exchangeable fractions of these materials are USGS42(Tibetan hair)δ(2)H(VSMOW-SLAP) = -78.5 ± 2.3‰ (n = 62) and δ(18)O(VSMOW-SLAP) = +8.56 ± 0.10‰ (n = 18) USGS42(Indian hair)δ(2)H(VSMOW-SLAP) = -50.3 ± 2.8‰ (n = 64) and δ(18)O(VSMOW-SLAP) = +14.11 ± 0.10‰ (n = 18). Using recommended analytical protocols presented herein for δ(2)H(VSMOW-SLAP) and δ(18)O(VSMOW-SLAP) measurements, the least squares fit regression of 11 human hair reference materials is δ(2)H(VSMOW-SLAP) = 6.085δ(2)O(VSMOW-SLAP) - 136.0‰ with an R-square value of 0.95. The δ(2)H difference between the calibrated results of human hair in this investigation and a commonly accepted human-hair relationship is a remarkable 34‰. It is critical that readers pay attention to the δ(2)H(VSMOW-SLAP) and δ(18)O(VSMOW-SLAP) of isotopic reference materials in publications, and they need to adjust the δ(2)H(VSMOW-SLAP) and δ(18)O(VSMOW-SLAP) measurement results of human hair in previous publications, as needed, to ensure all results on are on the same scales.

  17. Estudo da utilização de materiais de referência nas análises de água por laboratórios envolvidos no sistema de acreditação Case study on the usage of reference materials in water analysis by laboratories involved in the accreditation system

    Directory of Open Access Journals (Sweden)

    Suzana Saboia de Moura

    2009-01-01

    Full Text Available O presente estudo propõe-se discutir o uso de materiais de referência (MR pelos laboratórios de ensaios de águas, sob o ponto de vista da aquisição dos materiais conforme o item "Aquisição de serviços e suprimentos" (4.6 da norma ABNT NBR ISO/IEC 17025. O papel dos MR nas análises químicas é fornecer referências metrológicas visando assegurar a rastreabilidade das medições. A rastreabilidade é um aspecto essencial da garantia da qualidade para se obter aceitação de dados analíticos nos mercados nacional e internacional. Neste estudo de caso, de caráter exploratório e qualitativo, uma pesquisa foi realizada junto a todos os laboratórios de ensaios prestadores de serviços analíticos para a Agência Nacional de Águas (ANA e envolvidos no sistema de acreditação pela Coordenação Geral de Acreditação do Inmetro (Cgcre/Inmetro, utilizando-se questionário estruturado e com 50% de retorno. Os resultados mostraram que são muito poucos os certificados de MR com reconhecimento de terceira parte, ou seja, por organismos de acreditação, segundo normas consagradas que tratam efetivamente da rastreabilidade metrológica. Propõe-se, finalmente, uma política para garantir, sempre que possível, a rastreabilidade dos resultados de ensaios dos laboratórios, na ausência de MR certificados.This paper aims at discussing the use of reference materials (RM by water testing laboratories, on the context of RM purchase, based on the requirements of the standard ABNT NBR ISO/IEC 17025, section "Purchasing services and supplies" (4.6. The role of RM in chemical analysis is to provide metrological reference to assure measurement traceability. This is an essential aspect of quality assurance in order to have analytical results accepted in the international market. In this case study, based on the methodological exploratory and qualitative approach, a questionnaire was sent to testing laboratories which provide analytical services to the

  18. 7 CFR 97.122 - Certified seed only election.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Certified seed only election. 97.122 Section 97.122 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... PLANT VARIETY AND PROTECTION Reissuance of Certificate § 97.122 Certified seed only election. When...

  19. 40 CFR 121.21 - When Administrator certifies.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false When Administrator certifies. 121.21... CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Certification by the Administrator § 121.21 When Administrator certifies. Certification by the Administrator that the discharge resulting from...

  20. 42 CFR 441.153 - Team certifying need for services.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Team certifying need for services. 441.153 Section... § 441.153 Team certifying need for services. Certification under § 441.152 must be made by terms..., certification must be made by an independent team that— (1) Includes a physician; (2) Has competence...

  1. 77 FR 43535 - Grantee Codes for Certified Radiofrequency Equipment

    Science.gov (United States)

    2012-07-25

    ... COMMISSION 47 CFR Part 2 Grantee Codes for Certified Radiofrequency Equipment AGENCY: Federal Communications... continue to have new ones to assign to parties that wish to certify new equipment. DATES: Effective August....gov . Summary of the Order 1. The Commission operates an equipment authorization program...

  2. 36 CFR 61.7 - Subgrants to certified local governments.

    Science.gov (United States)

    2010-07-01

    ... INTERIOR PROCEDURES FOR STATE, TRIBAL, AND LOCAL GOVERNMENT HISTORIC PRESERVATION PROGRAMS § 61.7 Subgrants to certified local governments. (a) Each SHPO must transfer at least 10 percent of its annual... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Subgrants to certified...

  3. 36 CFR 61.6 - Certified local government programs.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Certified local government... INTERIOR PROCEDURES FOR STATE, TRIBAL, AND LOCAL GOVERNMENT HISTORIC PRESERVATION PROGRAMS § 61.6 Certified local government programs. (a) Each approved State program must provide a mechanism for...

  4. 27 CFR 478.95 - Certified copy of license.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Certified copy of license... Conduct of Business § 478.95 Certified copy of license. The license furnished to each person licensed... the licensee desires an additional copy of the license for certification (instead of making...

  5. 7 CFR 97.179 - Copies and certified copies.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Copies and certified copies. 97.179 Section 97.179... PLANT VARIETY AND PROTECTION Fees and Charges § 97.179 Copies and certified copies. (a) Upon request, copies of applications, certificates, or of any records, books, papers, drawings, or photographs in...

  6. 19 CFR 115.9 - Certifying Authorities responsibilities-containers.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Certifying Authorities responsibilities-containers...; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Administration § 115.9 Certifying Authorities responsibilities—containers. (a) General....

  7. 7 CFR 97.143 - Certified seed only.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Certified seed only. 97.143 Section 97.143 Agriculture... PLANT VARIETY AND PROTECTION Marking Or Labeling Provisions § 97.143 Certified seed only. (a) Upon filing an application, or amendment thereto, specifying seed of the variety is to be sold by variety...

  8. Development of two fine particulate matter standard reference materials (<4 μm and <10 μm) for the determination of organic and inorganic constituents.

    Science.gov (United States)

    Schantz, Michele M; Cleveland, Danielle; Heckert, N Alan; Kucklick, John R; Leigh, Stefan D; Long, Stephen E; Lynch, Jennifer M; Murphy, Karen E; Olfaz, Rabia; Pintar, Adam L; Porter, Barbara J; Rabb, Savelas A; Vander Pol, Stacy S; Wise, Stephen A; Zeisler, Rolf

    2016-06-01

    Two new Standard Reference Materials (SRMs), SRM 2786 Fine Particulate Matter (Filter Media. As such, these SRMs will be useful as quality control samples for ensuring compatibility of results among PM monitoring studies and will fill a void to assess the accuracy of analytical methods used in these studies. Graphical Abstract Removal of PM from filter for the preparation of SRM 2786 Fine Particulate Matter. PMID:27074778

  9. Certified metamodels for sensitivity indices estimation

    Directory of Open Access Journals (Sweden)

    Prieur Clémentine

    2012-04-01

    Full Text Available Global sensitivity analysis of a numerical code, more specifically estimation of Sobol indices associated with input variables, generally requires a large number of model runs. When those demand too much computation time, it is necessary to use a reduced model (metamodel to perform sensitivity analysis, whose outputs are numerically close to the ones of the original model, while being much faster to run. In this case, estimated indices are subject to two kinds of errors: sampling error, caused by the computation of the integrals appearing in the definition of the Sobol indices by a Monte-Carlo method, and metamodel error, caused by the replacement of the original model by the metamodel. In cases where we have certified bounds for the metamodel error, we propose a method to quantify both types of error, and we compute confidence intervals for first-order Sobol indices. L’analyse de sensibilité globale d’un modèle numérique, plus précisément l’estimation des indices de Sobol associés aux variables d’entrée, nécessite généralement un nombre important d’exécutions du modèle à analyser. Lorsque celles-ci requièrent un temps de calcul important, il est judicieux d’effectuer l’analyse de sensibilité sur un modèle réduit (ou métamodèle, fournissant des sorties numériquement proches du modèle original mais pour un coût nettement inférieur. Les indices estimés sont alors entâchés de deux sortes d’erreur : l’erreur d’échantillonnage, causée par l’estimation des intégrales définissant les indices de Sobol par une méthode de Monte-Carlo, et l’erreur de métamodèle, liée au remplacement du modèle original par le métamodèle. Lorsque nous disposons de bornes d’erreurs certifiées pour le métamodèle, nous proposons une méthode pour quantifier les deux types d’erreurs et fournir des intervalles de confiance pour les indices de Sobol du premier ordre.

  10. Controlul materialelor forestiere de reproducere: trasabilitatea genetică, contribuţie la gestionarea durabilă a pădurilor [The control of the forest reproductive material: the genetic traceability, support for forest certifi cation and a sustainable forest management

    Directory of Open Access Journals (Sweden)

    Teodosiu Maria

    2014-12-01

    Full Text Available For a sustainable forest management, beside the choice of the right species in artificial regeneration, the right provenances present their own importance. The existing legal regulation on forest reproductive material moving in trade can only provide an absolute proof of identity, at an unproportionally intense level of controlling. Techniques based on the analysis of DNA markers are a powerful tool for the genetic traceability of forest reproductive material, but on a European level, the traceability systems are yet missing, excepting the two certification systems implemented in Germany (ZüF and FfV. The reference samples collected from individuals in different steps of the forest reproductive material production, and the comparison of their genetic composition, are the principle underlying the German certification systems. The seeds from seed orchards can be identified with highly polymorphic SSR markers, once the the genetic profile of the reference clone is known, without reference samples. For different pourpose, suitable DNA markers are available, and the nuclear microsatellies are the more usefull in individual identification. Different statistical approaches can still be used to assign individual or groups of individuals to a population, but this requires further evaluation for their use in traceability. The control procedures are under development at European level. Their implementation are necessary also in Romania, as connecting to the present scientifical trends, and also related to its position as seeds provided for other European countries.

  11. What is in a label? Rainforest-Alliance certified banana production versus non-certified conventional banana production

    Directory of Open Access Journals (Sweden)

    Angelina Sanderson Bellamy

    2016-07-01

    Full Text Available Export banana production in Latin America is pesticide intensive, receiving much negative publicity regarding human health problems and environmental degradation. The Rainforest Alliance (RA certification scheme was established to certify farms that met a number of social, occupation health and environmental standards set by RA and their certifying body, the Sustainable Agriculture Network (SAN. This study was one of the first, independent studies of the environmental impact of some of the principles set by RA and SAN. The study focuses on insect and bird diversity as an indicator of ecosystem health. Five RA certified farms, six non-RA certified farms, and five organic certified farms were sampled. The data was analyzed with RDA multivariate analyses and Monte Carlo permutation tests. The results showed that RA certified farms had less insect diversity compared to non-RA certified farms and that both farm types had less insect diversity than organic farms. There was little difference between RA and non-RA certified farms with regards bird community composition. Thus, organic farming conserves biodiversity, while alternative environmental labels (e.g. a Rainforest alliance seal may not have any visible positive effect on in-farm biodiversity. This study points to the need for improvements in SAN certification standards to achieve improved environmental conditions.

  12. New Robust Reference Materials for In Situ Single Grain Rutile U-Pb Geochronology and Method Refinements for Detrital Rutile Analysis by LA-MC-ICP-MS

    Science.gov (United States)

    Parrish, R. R.; Bracciali, L.; Condon, D. J.; Horstwood, M. S.; Najman, Y.

    2012-12-01

    While rutile (TiO2) occurs in the heavy mineral suite of detrital sediments and originates mainly in medium- to high-grade metamorphic and some igneous rocks, there are very few applications of U-Pb dating of rutile to provenance studies; this is due to an overreliance on zircon, low U content of rutile limiting measurement quality by in situ methods, a higher proportion of common Pb relative to zircon, and a lack of widely available good quality reference materials. We have addressed these issues and characterized two ~ 1.8 Ga rutile reference materials by SEM, trace elements, U-Pb ID-TIMS, and intra-grain and inter-grain U-Pb LA-MC-ICP-MS analysis using mixed faraday and multiple ion counting detectors with high sensitivity. We have assessed U-Pb discordance and in situ variations in relative common Pb and age and their bearing on the quality of the reference materials for in situ U-Pb dating. The rutiles (Sugluk-4 and PCA-S207) come from granulite facies belts of the Canadian Shield, namely the northern Cape Smith Belt of Quebec and the Snowbird Tectonic Zone (Sasatchewan). The ID-TIMS data are slightly discordant due to variable common Pb and limited Pb loss; the variation in 6 single grains of Sugluk-4, that we use as the primary reference material, is British Columbia, Bhutan, and the Brahmaputra River of NE India (predominant rutile ages ~ 50, 15, and 2 Ma, respectively; Bracciali et al., this meeting). Our method successfully dates >75% of all rutile grains in a sediment; unsuccessful analyses are due to poor quality rutiles with massive common Pb and/or U contents < ~1ppm. While some analyses are therefore unusable, unlike zircon age zoning is rare to absent in rutile and there is little need to image grains to identify 'inheritance' to arrive at a correct interpretation of measured ages. Rutile has a ~ 500°C closure temperature and thus records mainly the time of cooling; it is therefore a sensitive recorder of metamorphic thermochronological information

  13. Aspects of quality of primary care provided by physicians certified in phytotherapy in Switzerland

    OpenAIRE

    Melzer, J.; Saller, R; Meier, B

    2008-01-01

    BACKGROUND: Data on the use of phytotherapy in primary care are scarce and difficult to compare (e.g. different health-care systems, study designs). OBJECTive: Are there differences in Switzerland regarding demographic data, practice structure, process of care and outcome/ treatment satisfaction between primary care physicians certified in phytotherapy (CAM) and physicians performing conventional primary care (COM) and their patients? MATERIAL AND METHODS: Subgroup analysis of the data of phy...

  14. A new organic reference material, L-glutamic acid, USGS41a, for δ13C and δ15N measurements − a replacement for USGS41

    Science.gov (United States)

    Qi, Haiping; Coplen, Tyler B.; Mroczkowski, Stanley J.; Brand, Willi A.; Brandes, Lauren; Geilmann, Heike; Schimmelmann, Arndt

    2016-01-01

    RationaleThe widely used l-glutamic acid isotopic reference material USGS41, enriched in both 13C and 15N, is nearly exhausted. A new material, USGS41a, has been prepared as a replacement for USGS41.MethodsUSGS41a was prepared by dissolving analytical grade l-glutamic acid enriched in 13C and 15N together with l-glutamic acid of normal isotopic composition. The δ13C and δ15N values of USGS41a were directly or indirectly normalized with the international reference materials NBS 19 calcium carbonate (δ13CVPDB = +1.95 mUr, where milliurey = 0.001 = 1 ‰), LSVEC lithium carbonate (δ13CVPDB = −46.6 mUr), and IAEA-N-1 ammonium sulfate (δ15NAir = +0.43 mUr) and USGS32 potassium nitrate (δ15N = +180 mUr exactly) by on-line combustion, continuous-flow isotope-ratio mass spectrometry, and off-line dual-inlet isotope-ratio mass spectrometry.ResultsUSGS41a is isotopically homogeneous; the reproducibility of δ13C and δ15N is better than 0.07 mUr and 0.09 mUr, respectively, in 200-μg amounts. It has a δ13C value of +36.55 mUr relative to VPDB and a δ15N value of +47.55 mUr relative to N2 in air. USGS41 was found to be hydroscopic, probably due to the presence of pyroglutamic acid. Experimental results indicate that the chemical purity of USGS41a is substantially better than that of USGS41.ConclusionsThe new isotopic reference material USGS41a can be used with USGS40 (having a δ13CVPDB value of −26.39 mUr and a δ15NAir value of −4.52 mUr) for (i) analyzing local laboratory isotopic reference materials, and (ii) quantifying drift with time, mass-dependent isotopic fractionation, and isotope-ratio-scale contraction for isotopic analysis of biological and organic materials. Published in 2016. This article is a U.S. Government work and is in the public domain in the USA.

  15. Synthesis and characterization of a new cation exchanger-zirconium(IV)iodotungstate: Separation and determination of metal ion contents of synthetic mixtures, pharmaceutical preparations and standard reference material

    International Nuclear Information System (INIS)

    Samples of zirconium(IV)iodotungstate have been synthesized under varying mixing order and ratios of aqueous solution of potassium iodate, sodium tungstate and zirconium oxychloride at pH 1. A tentative formula was proposed on the basis of chemical composition, FTIR and thermogravimetric studies. The material shows a capacity of 0.68 meq g-1 (for K+) which can be retained up to 200 deg. C. pH titration data reveal its monofunctional behavior. The distribution coefficient values of metal ions have been determined in various solvent systems. A number of important and analytically difficult quantitative separations of metal ions have been achieved using columns packed with this exchanger. In order to demonstrate practical utility of this material, Hg2+ and Pb2+ have been selectively separated and determined in the synthetic mixtures. Assay of Al3+ and Mg2+ in commercial tablets and analysis of lead in the standard reference material have also been attempted.

  16. Physical fitness training reference manual for security force personnel at fuel cycle facilities possessing formula quantities of special nuclear materials

    International Nuclear Information System (INIS)

    The recommendations contained throughout this NUREG are being provided to the Nuclear Regulatory Commission (NRC) as a reference manual which can be used by licensee management as they develop a program plan for the safe participation of guards, Tactical Response Team members (TRTs), and all other armed response personnel in physical fitness training and in physical performance standards testing. The information provided in this NUREG will help licensees to determine if guards, TRTs, and other armed response personnel can effectively perform their normal and emergency duties without undue hazard to themselves, to fellow employees, to the plant site, and to the general public. The recommendations in this NUREG are similar in part to those contained within the Department of Energy (DOE) Medical and Fitness Implementation Guide which was published in March 1991. The guidelines contained in this NUREG are not requirements, and compliance is not required. 25 refs

  17. Physical fitness training reference manual for security force personnel at fuel cycle facilities possessing formula quantities of special nuclear materials

    Energy Technology Data Exchange (ETDEWEB)

    Arzino, P.A.; Caplan, C.S.; Goold, R.E. (California State Univ., Hayward, CA (United States). Foundation)

    1991-09-01

    The recommendations contained throughout this NUREG are being provided to the Nuclear Regulatory Commission (NRC) as a reference manual which can be used by licensee management as they develop a program plan for the safe participation of guards, Tactical Response Team members (TRTs), and all other armed response personnel in physical fitness training and in physical performance standards testing. The information provided in this NUREG will help licensees to determine if guards, TRTs, and other armed response personnel can effectively perform their normal and emergency duties without undue hazard to themselves, to fellow employees, to the plant site, and to the general public. The recommendations in this NUREG are similar in part to those contained within the Department of Energy (DOE) Medical and Fitness Implementation Guide which was published in March 1991. The guidelines contained in this NUREG are not requirements, and compliance is not required. 25 refs.

  18. A revision in hydrogen isotopic composition of USGS42 and USGS43 human-hair stable isotopic reference materials for forensic science.

    Science.gov (United States)

    Coplen, Tyler B; Qi, Haiping

    2016-09-01

    The hydrogen isotopic composition (δ(2)HVSMOW-SLAP) of USGS42 and USGS43 human hair stable isotopic reference materials, normalized to the VSMOW (Vienna-Standard Mean Ocean Water)-SLAP (Standard Light Antarctic Precipitation) scale, was originally determined with a high temperature conversion technique using an elemental analyzer (TC/EA) with a glassy carbon tube and glassy carbon filling and analysis by isotope-ratio mass spectrometer (IRMS). However, the TC/EA IRMS method can produce inaccurate δ(2)HVSMOW-SLAP results when analyzing nitrogen-bearing organic substances owing to the formation of hydrogen cyanide (HCN), leading to non-quantitative conversion of a sample into molecular hydrogen (H2) for IRMS analysis. A single-oven, chromium-filled, elemental analyzer (Cr-EA) coupled to an IRMS substantially improves the measurement quality and reliability of hydrogen isotopic analysis of hydrogen- and nitrogen-bearing organic material because hot chromium scavenges all reactive elements except hydrogen. USGS42 and USGS43 human hair isotopic reference materials have been analyzed with the Cr-EA IRMS method, and the δ(2)HVSMOW-SLAP values of their non-exchangeable hydrogen fractions have been revised: [Formula: see text] [Formula: see text] where mUr=0.001=‰. On average, these revised δ(2)HVSMOW-SLAP values are 5.7mUr more positive than those previously measured. It is critical that readers pay attention to the δ(2)HVSMOW-SLAP of isotopic reference materials in publications as they may need to adjust the δ(2)HVSMOW-SLAP measurement results of human hair in previous publications to ensure all results are on the same isotope-delta scale.

  19. 7 CFR 205.100 - What has to be certified.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Applicability § 205.100 What has to be certified. (a) Except...

  20. Water Well Locations - MO 2012 Certified Wells (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This data set provides information about wells that are certified by the State of Missouri. The parent data set is the Wellhead Information Management System (WIMS)...