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Sample records for central pattern generator

  1. Central pattern generation underlying Limulus rhythmic behavior patterns

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    Gordon A. Wyse

    2010-10-01

    Full Text Available Many behavioral activities of the horseshoe crab Limulus are rhythmic, and most of these are produced in large part by central pattern generators within the CNS. The chain of opisthosomal (‘abdominal’ ganglia controls gill movements of ventilation and gill cleaning, and the prosomal ring of fused ganglia (brain and segmental ‘thoracic’ ganglia controls generation of feeding and locomotor movements of the legs. Both the opisthosomal CNS and the prosomal CNS can generate behaviorally appropriate patterns of motor output in isolation, without movements or sensory input. Preparations of the isolated opisthosomal CNS generate rhythmic output patterns of motor activity characterized as fictive ventilatory and gill cleaning rhythms. Moreover, CNS preparations also express longer-term patterns, such as intermittent ventilation or sequential bouts of ventilation and gill cleaning. Such longer-term patterns are commonly observed in intact animals. The isolated prosomal CNS does not spontaneously generate the activity patterns characteristic of walking, swimming, and feeding. However, perfusion of octopamine in the isolated prosomal CNS activates central pattern generators underlying rhythmic chewing movements, and injection of octopamine into intact Limulus promotes the chewing pattern of feeding, whether or not food is presented. Our understanding of the ability of neuromodulators such as octopamine to elicit or alter central motor programs may help to clarify the central neural circuits of pattern generation that produce and coordinate these rhythmic behaviors [Current Zoology 56 (5: 537–549, 2010].

  2. Central Pattern Generator Based Omnidirectional Locomotion for Quadrupedal Robotics

    Science.gov (United States)

    2014-09-01

    revolute joint is controlled with a 90W Maxon brushless DC motor with an 86:1 ceramic planetary gearhead and is sensed directly at the motor with a 1000...many animals use central pattern generators (CPGs) for generating joint trajectories and regulation through sensory feedback. However, CPG models ...notable exceptions [7], [8]), the bulk of research has focused on design of steady state forward gaits. The majority of CPG models , when they do specify a

  3. Central pattern generator for vocalization: is there a vertebrate morphotype?

    Science.gov (United States)

    Bass, Andrew H

    2014-10-01

    Animals that generate acoustic signals for social communication are faced with two essential tasks: generate a temporally precise signal and inform the auditory system about the occurrence of one's own sonic signal. Recent studies of sound producing fishes delineate a hindbrain network comprised of anatomically distinct compartments coding equally distinct neurophysiological properties that allow an organism to meet these behavioral demands. A set of neural characters comprising a vocal-sonic central pattern generator (CPG) morphotype is proposed for fishes and tetrapods that shares evolutionary developmental origins with pectoral appendage motor systems.

  4. Evolution of central pattern generators and rhythmic behaviours.

    Science.gov (United States)

    Katz, Paul S

    2016-01-01

    Comparisons of rhythmic movements and the central pattern generators (CPGs) that control them uncover principles about the evolution of behaviour and neural circuits. Over the course of evolutionary history, gradual evolution of behaviours and their neural circuitry within any lineage of animals has been a predominant occurrence. Small changes in gene regulation can lead to divergence of circuit organization and corresponding changes in behaviour. However, some behavioural divergence has resulted from large-scale rewiring of the neural network. Divergence of CPG circuits has also occurred without a corresponding change in behaviour. When analogous rhythmic behaviours have evolved independently, it has generally been with different neural mechanisms. Repeated evolution of particular rhythmic behaviours has occurred within some lineages due to parallel evolution or latent CPGs. Particular motor pattern generating mechanisms have also evolved independently in separate lineages. The evolution of CPGs and rhythmic behaviours shows that although most behaviours and neural circuits are highly conserved, the nature of the behaviour does not dictate the neural mechanism and that the presence of homologous neural components does not determine the behaviour. This suggests that although behaviour is generated by neural circuits, natural selection can act separately on these two levels of biological organization.

  5. Central pattern generator for locomotion: anatomical, physiological, and pathophysiological considerations.

    Science.gov (United States)

    Guertin, Pierre A

    2012-01-01

    This article provides a perspective on major innovations over the past century in research on the spinal cord and, specifically, on specialized spinal circuits involved in the control of rhythmic locomotor pattern generation and modulation. Pioneers such as Charles Sherrington and Thomas Graham Brown have conducted experiments in the early twentieth century that changed our views of the neural control of locomotion. Their seminal work supported subsequently by several decades of evidence has led to the conclusion that walking, flying, and swimming are largely controlled by a network of spinal neurons generally referred to as the central pattern generator (CPG) for locomotion. It has been subsequently demonstrated across all vertebrate species examined, from lampreys to humans, that this CPG is capable, under some conditions, to self-produce, even in absence of descending or peripheral inputs, basic rhythmic, and coordinated locomotor movements. Recent evidence suggests, in turn, that plasticity changes of some CPG elements may contribute to the development of specific pathophysiological conditions associated with impaired locomotion or spontaneous locomotor-like movements. This article constitutes a comprehensive review summarizing key findings on the CPG as well as on its potential role in Restless Leg Syndrome, Periodic Leg Movement, and Alternating Leg Muscle Activation. Special attention will be paid to the role of the CPG in a recently identified, and uniquely different neurological disorder, called the Uner Tan Syndrome.

  6. Symmetry in locomotor central pattern generators and animal gaits

    Science.gov (United States)

    Golubitsky, Martin; Stewart, Ian; Buono, Pietro-Luciano; Collins, J. J.

    1999-10-01

    Animal locomotion is controlled, in part, by a central pattern generator (CPG), which is an intraspinal network of neurons capable of generating a rhythmic output. The spatio-temporal symmetries of the quadrupedal gaits walk, trot and pace lead to plausible assumptions about the symmetries of locomotor CPGs. These assumptions imply that the CPG of a quadruped should consist of eight nominally identical subcircuits, arranged in an essentially unique matter. Here we apply analogous arguments to myriapod CPGs. Analyses based on symmetry applied to these networks lead to testable predictions, including a distinction between primary and secondary gaits, the existence of a new primary gait called `jump', and the occurrence of half-integer wave numbers in myriapod gaits. For bipeds, our analysis also predicts two gaits with the out-of-phase symmetry of the walk and two gaits with the in-phase symmetry of the hop. We present data that support each of these predictions. This work suggests that symmetry can be used to infer a plausible class of CPG network architectures from observed patterns of animal gaits.

  7. Central Pattern Generator for Locomotion: Anatomical, Physiological and Pathophysiological Considerations

    Directory of Open Access Journals (Sweden)

    Pierre A. Guertin

    2013-02-01

    Full Text Available This article provides a perspective on major innovations over the past century in research on the spinal cord and, specifically, on specialized spinal circuits involved in the control of rhythmic locomotor pattern generation and modulation. Pioneers such as Charles Sherrington and Thomas Graham Brown have conducted experiments in the early twentieth century that changed our views of the neural control of locomotion. Their seminal work supported subsequently by several decades of evidence has led to the conclusion that walking, flying and swimming are largely controlled by a network of spinal neurons generally referred to as the central pattern generator (CPG for locomotion. It has been subsequently demonstrated across all vertebrate species examined, from lampreys to humans, that this CPG is capable, under some conditions, to self-produce, even in absence of descending or peripheral inputs, basic rhythmic and coordinated locomotor movements. Recent evidence suggests, in turn, that plasticity changes of some CPG elements may contribute to the development of specific pathophysiological conditions associated with impaired locomotion or spontaneous locomotor-like movements. This article constitutes a comprehensive review summarizing key findings on the CPG as well as on its potential role in Restless Leg Syndrome (RLS, Periodic Leg Movement (PLM, and Alternating Leg Muscle Activation (ALMA. Special attention will be paid to the role of the CPG in a recently identified, and uniquely different neurological disorder, called the Uner Tan Syndrome.

  8. Analog electronic model of the lobster pyloric central pattern generator

    Energy Technology Data Exchange (ETDEWEB)

    Volkovskii, A [Institute for Nonlinear Science, University of California San Diego, CA (United States); Brugioni, S [Institute for Nonlinear Science, University of California San Diego, CA (United States); Istituto Nazionale di Ottica Applicata Largo E. Fermi 6 50125 Florence (Italy); Levi, R [Institute for Nonlinear Science, University of California San Diego, CA (United States); Rabinovich, M [Institute for Nonlinear Science, University of California San Diego, CA (United States); Selverston, A [Institute for Nonlinear Science, University of California San Diego, CA (United States); Abarbane, H D I [Institute for Nonlinear Science, University of California San Diego, CA (United States)

    2005-01-01

    An electronic circuit intended to simulate the nonlinear dynamics of a simplified 3-cell model of the pyloric central pattern generator in California spiny lobster stomato gastric ganglion is presented. The model employs the synaptic phase locked loop (SPLL) concept where the frequency of oscillations of a postsynaptic cell is mainly controlled by the synaptic current which depends on the phase shift between the oscillations. The theoretical study showed that the system has a stable steady state with correct phase shifts between the oscillations and that this regime is stable when the frequency of the pacemaker cell is varied over a wide range. The main bifurcations in the system were studied analytically, in computer simulations, and in experiments with the electronic circuit. The experimental measurements are in good agreement with the expectations of the theoretical model.

  9. Energy efficient and robust rhythmic limb movement by central pattern generators

    NARCIS (Netherlands)

    Verdaasdonk, B.W.; Koopman, H.F.J.M.; Helm, van der F.C.T.

    2006-01-01

    Humans show great energy efficiency and robustness in rhythmic tasks, such as walking and arm swinging. In this study a mathematical model of rhythmic limb movement is presented, which shows that tight local coupling of Central Pattern Generators (CPGs) to limbs could explain part of this behavior.

  10. Energy efficient walking with central pattern generators: from passive dynamic walking to biologically inspired control

    NARCIS (Netherlands)

    Verdaasdonk, B.W.; Koopman, H.F.J.M.; Van der Helm, F.C.T.

    2009-01-01

    Like human walking, passive dynamic walking—i.e. walking down a slope with no actuation except gravity—is energy efficient by exploiting the natural dynamics. In the animal world, neural oscillators termed central pattern generators (CPGs) provide the basic rhythm for muscular activity in locomotion

  11. Sensor-Based Programming of Central Pattern Generators in Humanoid Robots

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    Hamed Shahbazi

    2013-04-01

    Full Text Available In the present article, a method for generating curvilinear bipedal walking patterns is proposed which is able to generate rhythmic and periodic trajectories for a Nao soccer player robot. To do so, a programmable central pattern generator was used which was inspired from locomotion structures in vertebrate animals. In this paper, the programmable central pattern generators were extended and new Equations were added to make a curvilinear pattern for walking Nao robots on a specified circular curve. In addition, some specific Equations were added to the model to control the arms and synchronize them with the movement of the feet. The model uses some sensory inputs to obtain some feedback from the movement and adjust it conforming to the potential perturbations. Input sensory values consist of accelerator values and foot pressure sensor values located on the bottom of each foot. Feedback values can adopt walking to some desired specifications and compensate the effects of some types of perturbations. The proposed model has many benefits including smooth walking patterns and modulation during walking. This model can be extended and used in the Nao soccer player both for the standard platform and the 3D soccer simulation leagues of Robocup SPL competitions to train different types of motions.

  12. Octopamine modulates a central pattern generator associated with egg-laying in the locust, Locusta migratoria.

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    Wong, Raymond; Lange, Angela B

    2014-04-01

    Egg-laying in Locusta migratoria involves the control of a variety of complex behavioural patterns including those that regulate digging of the oviposition hole and retention of eggs during digging. These two behavioural patterns are under the control of central pattern generators (CPGs). The digging and egg-retention CPGs are coordinated and integrated with overlapping locations of neural substrate within the VIIth and VIIIth abdominal ganglia of the central nervous system (CNS). In fact, the egg-retention CPG of the VIIth abdominal ganglion is involved in both egg-retention and protraction of the abdomen during digging. The biogenic amine, octopamine, has peripheral effects on oviduct muscle, relaxing basal tension of the lateral and upper common oviduct and enabling egg passage. Here we show that octopamine also modulates the pattern of the egg-retention CPG by altering the motor pattern that controls the external ventral protractor of the VIIth abdominal segment. There is no change in the motor pattern that goes to the oviducts. Octopamine decreased the frequency of the largest amplitude action potential and decreased burst duration while leading to an increase in cycle duration and interburst interval. The effects of octopamine were greatly reduced in the presence of the α-adrenergic blocker, phentolamine, indicating that the action of octopamine was via a receptor. Thus, octopamine orchestrates events that can lead to oviposition, centrally inhibiting the digging behavior and peripherally relaxing the lateral and common oviducts to enable egg-laying.

  13. From Spinal Central Pattern Generators to Cortical Network: Integrated BCI for Walking Rehabilitation

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    G. Cheron

    2012-01-01

    Full Text Available Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs. Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information regarding central pattern generation functioning. In addition, there is also a tight coordination between the upper and lower limbs, which can also be useful in controlling locomotion. The current paper critically investigates different approaches that are applicable to this field: the use of electroencephalogram (EEG, upper limb electromyogram (EMG, or a hybrid of the two neurophysiological signals to control assistive exoskeletons used in locomotion based on programmable central pattern generators (PCPGs or dynamic recurrent neural networks (DRNNs. Plantar surface tactile stimulation devices combined with virtual reality may provide the sensation of walking while in a supine position for use of training brain signals generated during locomotion. These methods may exploit mechanisms of brain plasticity and assist in the neurorehabilitation of gait in a variety of clinical conditions, including stroke, spinal trauma, multiple sclerosis, and cerebral palsy.

  14. Central generation of grooming motor patterns and interlimb coordination in locusts.

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    Berkowitz, A; Laurent, G

    1996-12-15

    Coordinated bursts of leg motoneuron activity were evoked in locusts with deefferented legs by tactile stimulation of sites that evoke grooming behavior. This suggests that insect thoracic ganglia contain central pattern generators for directed leg movements. Motoneuron recordings were made from metathoracic and mesothoracic nerves, after eliminating all leg motor innervation, as well as all input from the brain, subesophageal ganglion, and prothoracic ganglion. Strong, brief trochanteral levator motoneuron bursts occurred, together with silence of the slow and fast trochanteral depressor motoneurons and activation of the common inhibitor motoneuron. The metathoracic slow tibial extensor motoneuron was active in a pattern distinct from its activity during walking or during rhythms evoked by the muscarinic agonist pilocarpine. Preparations in which the metathoracic ganglion was isolated from all other ganglia could still produce fictive motor patterns in response to tactile stimulation of metathoracic locations. Bursts of trochanteral levator and depressor motoneurons were clearly coordinated between the left and right metathoracic hemiganglia and also between the mesothoracic and the ipsilateral metathoracic ganglia. These data provide clear evidence for centrally generated interlimb coordination in an insect.

  15. Global stability of synchronous and out-of-phase oscillations in central pattern generators

    CERN Document Server

    Landsman, A S

    2010-01-01

    Coupled arrays of Andronov-Hopf oscillators are investigated. These arrays can be diffusively or repulsively coupled, and can serve as central pattern generator models in animal locomotion and robotics. It is shown that repulsive coupling generates out-of-phase oscillations, while diffusive coupling generates synchronous oscillations. Specifically, symmetric solutions and their corresponding amplitudes are derived, and contraction analysis is used to prove global stability and convergence of oscillations to either symmetric out-of-phase or synchronous states, depending on the coupling constant. Next, the two mechanisms are used jointly by coupling multiple arrays. The resulting dynamics is analyzed, in a model inspired by the CPG-motorneuron network that controls the heartbeat of a medicinal leech.

  16. Study on dynamics of central pattern generator model for a quadrupedal robot

    Institute of Scientific and Technical Information of China (English)

    Zhang Xiuli; Zheng Haojun

    2007-01-01

    Based on Matsuoka's central pattern generator(CPG)model and taking quadmped as an example,the dynamics of CPG model was investigated throush the single-parameter-analysis method and the numerical simulation technique.Simulation results indicate that the CPG model exhibits complex dynamics,while each parameter has specifically definitive influenco trends on the CPG output.These conclusions re applied to control a quadrupedal robot to walk in different gaits,clear obstacle,and walk up-and down-slope successfully.

  17. Localization of Motor Neurons and Central Pattern Generators for Motor Patterns Underlying Feeding Behavior in Drosophila Larvae.

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    Sebastian Hückesfeld

    Full Text Available Motor systems can be functionally organized into effector organs (muscles and glands, the motor neurons, central pattern generators (CPG and higher control centers of the brain. Using genetic and electrophysiological methods, we have begun to deconstruct the motor system driving Drosophila larval feeding behavior into its component parts. In this paper, we identify distinct clusters of motor neurons that execute head tilting, mouth hook movements, and pharyngeal pumping during larval feeding. This basic anatomical scaffold enabled the use of calcium-imaging to monitor the neural activity of motor neurons within the central nervous system (CNS that drive food intake. Simultaneous nerve- and muscle-recordings demonstrate that the motor neurons innervate the cibarial dilator musculature (CDM ipsi- and contra-laterally. By classical lesion experiments we localize a set of CPGs generating the neuronal pattern underlying feeding movements to the subesophageal zone (SEZ. Lesioning of higher brain centers decelerated all feeding-related motor patterns, whereas lesioning of ventral nerve cord (VNC only affected the motor rhythm underlying pharyngeal pumping. These findings provide a basis for progressing upstream of the motor neurons to identify higher regulatory components of the feeding motor system.

  18. Key bifurcations of bursting polyrhythms in 3-cell central pattern generators.

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    Jeremy Wojcik

    Full Text Available We identify and describe the key qualitative rhythmic states in various 3-cell network motifs of a multifunctional central pattern generator (CPG. Such CPGs are neural microcircuits of cells whose synergetic interactions produce multiple states with distinct phase-locked patterns of bursting activity. To study biologically plausible CPG models, we develop a suite of computational tools that reduce the problem of stability and existence of rhythmic patterns in networks to the bifurcation analysis of fixed points and invariant curves of a Poincaré return maps for phase lags between cells. We explore different functional possibilities for motifs involving symmetry breaking and heterogeneity. This is achieved by varying coupling properties of the synapses between the cells and studying the qualitative changes in the structure of the corresponding return maps. Our findings provide a systematic basis for understanding plausible biophysical mechanisms for the regulation of rhythmic patterns generated by various CPGs in the context of motor control such as gait-switching in locomotion. Our analysis does not require knowledge of the equations modeling the system and provides a powerful qualitative approach to studying detailed models of rhythmic behavior. Thus, our approach is applicable to a wide range of biological phenomena beyond motor control.

  19. Biological oscillations for learning walking coordination: dynamic recurrent neural network functionally models physiological central pattern generator.

    Science.gov (United States)

    Hoellinger, Thomas; Petieau, Mathieu; Duvinage, Matthieu; Castermans, Thierry; Seetharaman, Karthik; Cebolla, Ana-Maria; Bengoetxea, Ana; Ivanenko, Yuri; Dan, Bernard; Cheron, Guy

    2013-01-01

    The existence of dedicated neuronal modules such as those organized in the cerebral cortex, thalamus, basal ganglia, cerebellum, or spinal cord raises the question of how these functional modules are coordinated for appropriate motor behavior. Study of human locomotion offers an interesting field for addressing this central question. The coordination of the elevation of the 3 leg segments under a planar covariation rule (Borghese et al., 1996) was recently modeled (Barliya et al., 2009) by phase-adjusted simple oscillators shedding new light on the understanding of the central pattern generator (CPG) processing relevant oscillation signals. We describe the use of a dynamic recurrent neural network (DRNN) mimicking the natural oscillatory behavior of human locomotion for reproducing the planar covariation rule in both legs at different walking speeds. Neural network learning was based on sinusoid signals integrating frequency and amplitude features of the first three harmonics of the sagittal elevation angles of the thigh, shank, and foot of each lower limb. We verified the biological plausibility of the neural networks. Best results were obtained with oscillations extracted from the first three harmonics in comparison to oscillations outside the harmonic frequency peaks. Physiological replication steadily increased with the number of neuronal units from 1 to 80, where similarity index reached 0.99. Analysis of synaptic weighting showed that the proportion of inhibitory connections consistently increased with the number of neuronal units in the DRNN. This emerging property in the artificial neural networks resonates with recent advances in neurophysiology of inhibitory neurons that are involved in central nervous system oscillatory activities. The main message of this study is that this type of DRNN may offer a useful model of physiological central pattern generator for gaining insights in basic research and developing clinical applications.

  20. Biological oscillations for learning walking coordination: dynamic recurrent neural network functionally models physiological central pattern generator

    Directory of Open Access Journals (Sweden)

    Thomas eHoellinger

    2013-05-01

    Full Text Available The existence of dedicated neuronal modules such as those organized in the cerebral cortex, thalamus, basal ganglia, cerebellum or spinal cord raises the question of how these functional modules are coordinated for appropriate motor behavior. Study of human locomotion offers an interesting field for addressing this central question. The coordination of the elevation of the 3 leg segments under a planar covariation rule (Borghese et al., 1996 was recently modeled (Barliya et al., 2009 by phase-adjusted simple oscillators shedding new light on the understanding of the central pattern generator processing relevant oscillation signals. We describe the use of a dynamic recurrent neural network (DRNN mimicking the natural oscillatory behavior of human locomotion for reproducing the planar covariation rule in both legs at different walking speeds. Neural network learning was based on sinusoid signals integrating frequency and amplitude features of the first three harmonics of the sagittal elevation angles of the thigh, shank and foot of each lower limb. We verified the biological plausibility of the neural networks. Best results were obtained with oscillations extracted from the first three harmonics in comparison to oscillations outside the harmonic frequency peaks. Physiological replication steadily increased with the number of neuronal units from 1 to 80, where similarity index reached 0.99. Analysis of synaptic weighting showed that the proportion of inhibitory connections consistently increased with the number of neuronal units in the DRNN. This emerging property in the artificial neural networks resonates with recent advances in neurophysiology of inhibitory neurons that are involved in central nervous system oscillatory activities. The main message of this study is that this type of DRNN may offer a useful model of physiological central pattern generator for gaining insights in basic research and developing clinical applications.

  1. Coupled chaotic oscillators and their relation to a central pattern generator for artificial quadrupeds

    Indian Academy of Sciences (India)

    Horacio Castellini; Efta Yudiarsah; Lilia Romanelli; Hilda A Cerdeira

    2005-04-01

    Animal locomotion employs different periodic patterns known as animal gaits. In 1993, Collins and Stewart recognized that gaits possessed certain symmetries and characterized the gaits of quadrupeds and bipeds using permutation symmetry groups, which impose constraints on the locomotion center called the central pattern generator (CPG) in the animal brain. They modeled the CPG by coupling four nonlinear oscillators and found that it was possible to reproduce all symmetries of the gaits by changing the coupling strength. Here we propose to extend this idea using coupled chaotic oscillators synchronized using the Pyragas method in order to characterize the CPG symmetries. We also evaluate the time series behavior when the foot is in contact with the ground: this has potential robotic applications.

  2. Control of traveling-wave oscillations and bifurcation behavior in central pattern generators

    Science.gov (United States)

    Landsman, Alexandra S.; Slotine, Jean-Jacques

    2012-10-01

    Understanding synchronous and traveling-wave oscillations, particularly as they relate to transitions between different types of behavior, is a central problem in modeling biological systems. Here, we address this problem in the context of central pattern generators (CPGs). We use contraction theory to establish the global stability of a traveling-wave or synchronous oscillation, determined by the type of coupling. This opens the door to better design of coupling architectures to create the desired type of stable oscillations. We then use coupling that is both amplitude and phase dependent to create either globally stable synchronous or traveling-wave solutions. Using the CPG motor neuron network of a leech as an example, we show that while both traveling and synchronous oscillations can be achieved by several types of coupling, the transition between different types of behavior is dictated by a specific coupling architecture. In particular, it is only the “repulsive” but not the commonly used phase or rotational coupling that can explain the transition to high-frequency synchronous oscillations that have been observed in the heartbeat pattern generator of a leech. This shows that the overall dynamics of a CPG can be highly sensitive to the type of coupling used, even for coupling architectures that are widely believed to produce the same qualitative behavior.

  3. Bio-inspired design strategies for central pattern generator control in modular robotics.

    Science.gov (United States)

    Herrero-Carrón, F; Rodríguez, F B; Varona, P

    2011-03-01

    New findings in the nervous system of invertebrates have shown how a number of features of central pattern generator (CPG) circuits contribute to the generation of robust flexible rhythms. In this paper we consider recently revealed strategies that living CPGs follow to design CPG control paradigms for modular robots. To illustrate them, we divide the task of designing an example CPG for a modular robot into independent problems. We formulate each problem in a general way and provide a bio-inspired solution for each of them: locomotion information coding, individual module control and inter-module coordination. We analyse the stability of the CPG numerically, and then test it on a real robot. We analyse steady state locomotion and recovery after perturbations. In both cases, the robot is able to autonomously find a stable effective locomotion state. Finally, we discuss how these strategies can result in a more general design approach for CPG-based locomotion.

  4. Bio-inspired Optimal Locomotion Reconfigurability of Quadruped Rovers using Central Pattern Generators

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    Bohra, Murtaza

    Legged rovers are often considered as viable solutions for traversing unknown terrain. This work addresses the optimal locomotion reconfigurability of quadruped rovers, which consists of obtaining optimal locomotion modes, and transitioning between them. A 2D sagittal plane rover model is considered based on a domestic cat. Using a Genetic Algorithm, the gait, pose and control variables that minimize torque or maximize speed are found separately. The optimization approach takes into account the elimination of leg impact, while considering the entire variable spectrum. The optimal solutions are consistent with other works on gait optimization, and are similar to gaits found in quadruped animals as well. An online model-free gait planning framework is also implemented, that is based on Central Pattern Generators is implemented. It is used to generate joint and control trajectories for any arbitrarily varying speed profile, and shown to regulate locomotion transition and speed modulation, both endogenously and continuously.

  5. Bio-inspired design strategies for central pattern generator control in modular robotics

    Energy Technology Data Exchange (ETDEWEB)

    Herrero-Carron, F; Rodriguez, F B; Varona, P, E-mail: fernando.herrero@uam.es, E-mail: f.rodriguez@uam.es, E-mail: pablo.varona@uam.es [Grupo de Neurocomputacion Biologica (GNB), Departamento de Ingenieria Informatica, Escuela Politecnica Superior, Universidad Autonoma de Madrid, Calle Francisco Tomas y Valiente, 11, 28049 Madrid (Spain)

    2011-03-15

    New findings in the nervous system of invertebrates have shown how a number of features of central pattern generator (CPG) circuits contribute to the generation of robust flexible rhythms. In this paper we consider recently revealed strategies that living CPGs follow to design CPG control paradigms for modular robots. To illustrate them, we divide the task of designing an example CPG for a modular robot into independent problems. We formulate each problem in a general way and provide a bio-inspired solution for each of them: locomotion information coding, individual module control and inter-module coordination. We analyse the stability of the CPG numerically, and then test it on a real robot. We analyse steady state locomotion and recovery after perturbations. In both cases, the robot is able to autonomously find a stable effective locomotion state. Finally, we discuss how these strategies can result in a more general design approach for CPG-based locomotion.

  6. Toward robust phase-locking in Melibe swim central pattern generator models

    Science.gov (United States)

    Jalil, Sajiya; Allen, Dane; Youker, Joseph; Shilnikov, Andrey

    2013-12-01

    Small groups of interneurons, abbreviated by CPG for central pattern generators, are arranged into neural networks to generate a variety of core bursting rhythms with specific phase-locked states, on distinct time scales, which govern vital motor behaviors in invertebrates such as chewing and swimming. These movements in lower level animals mimic motions of organs in higher animals due to evolutionarily conserved mechanisms. Hence, various neurological diseases can be linked to abnormal movement of body parts that are regulated by a malfunctioning CPG. In this paper, we, being inspired by recent experimental studies of neuronal activity patterns recorded from a swimming motion CPG of the sea slug Melibe leonina, examine a mathematical model of a 4-cell network that can plausibly and stably underlie the observed bursting rhythm. We develop a dynamical systems framework for explaining the existence and robustness of phase-locked states in activity patterns produced by the modeled CPGs. The proposed tools can be used for identifying core components for other CPG networks with reliable bursting outcomes and specific phase relationships between the interneurons. Our findings can be employed for identifying or implementing the conditions for normal and pathological functioning of basic CPGs of animals and artificially intelligent prosthetics that can regulate various movements.

  7. Asymmetry Factors Shaping Regular and Irregular Bursting Rhythms in Central Pattern Generators

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    Elices, Irene; Varona, Pablo

    2017-01-01

    Central Pattern Generator (CPG) circuits are neural networks that generate rhythmic motor patterns. These circuits are typically built of half-center oscillator subcircuits with reciprocally inhibitory connections. Another common property in many CPGs is the remarkable rich spiking-bursting dynamics of their constituent cells, which balance robustness and flexibility to generate their joint coordinated rhythms. In this paper, we use conductance-based models and realistic connection topologies inspired by the crustacean pyloric CPG to address the study of asymmetry factors shaping CPG bursting rhythms. In particular, we assess the role of asymmetric maximal synaptic conductances, time constants and gap-junction connectivity to establish the regularity of half-center oscillator based CPGs. We map and characterize the synaptic parameter space that lead to regular and irregular bursting activity in these networks. The analysis indicates that asymmetric configurations display robust regular rhythms and that large regions of both regular and irregular but coordinated rhythms exist as a function of the asymmetry in the circuit. Our results show that asymmetry both in the maximal conductances and in the temporal dynamics of mutually inhibitory neurons can synergistically contribute to shape wide regimes of regular spiking-bursting activity in CPGs. Finally, we discuss how a closed-loop protocol driven by a regularity goal can be used to find and characterize regular regimes when there is not time to perform an exhaustive search, as in most experimental studies. PMID:28261081

  8. Implementation of Imitation Learning using Natural Learner Central Pattern Generator Neural Networks.

    Science.gov (United States)

    Shahbazi, Hamed; Parandeh, Reyhaneh; Jamshidi, Kamal

    2016-11-01

    In this paper a new design of neural networks is introduced, which is able to generate oscillatory patterns. The fundamental building block of the neural network is O-neurons that can generate an oscillation in its transfer functions. Since the natural policy gradient learning has been used in training a central pattern generator paradigm, it is called Natural Learner CPG Neural Networks (NLCPGNN). O-neurons are connected and coupled to each other in order to shape a network and their unknown parameters are found by a natural policy gradient learning algorithm. The main contribution of this paper is design of this learning algorithm which is able to simultaneously search for the weights and topology of the network. This system is capable to obtain any complex motion and rhythmic trajectory via first layer and learn rhythmic trajectories in the second layer and converge towards all these movements. Moreover this two layers system is able to provide various features of a learner model for instance resistance against perturbations, modulation of trajectories amplitude and frequency. Simulation of the learning system in the robot simulator (WEBOTS) that is linked with MATLAB software has been done. Implementation on a real NAO robot demonstrates that the robot has learned desired motion with high accuracy. These results show proposed system produces high convergence rate and low test errors.

  9. Emergent Central Pattern Generator Behavior in Gap-Junction-Coupled Hodgkin-Huxley Style Neuron Model

    Directory of Open Access Journals (Sweden)

    Kyle G. Horn

    2012-01-01

    Full Text Available Most models of central pattern generators (CPGs involve two distinct nuclei mutually inhibiting one another via synapses. Here, we present a single-nucleus model of biologically realistic Hodgkin-Huxley neurons with random gap junction coupling. Despite no explicit division of neurons into two groups, we observe a spontaneous division of neurons into two distinct firing groups. In addition, we also demonstrate this phenomenon in a simplified version of the model, highlighting the importance of afterhyperpolarization currents ( to CPGs utilizing gap junction coupling. The properties of these CPGs also appear sensitive to gap junction conductance, probability of gap junction coupling between cells, topology of gap junction coupling, and, to a lesser extent, input current into our simulated nucleus.

  10. Reticular activating system of a central pattern generator: premovement electrical potentials.

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    Tapia, Jesus A; Trejo, Argelia; Linares, Pablo; Alva, J Manuel; Kristeva, Rumyana; Manjarrez, Elias

    2013-10-01

    For the first time, here we characterize a bulbar reticular activating system (RAS) of neurons in decerebrate, deafferented and decerebellated cats producing a premovement electrical potential that we named obex slow potential (OSP). The OSP occurs about 0.8 ± 0.4 sec prior to the onset of a fictive-scratching-episode. Here, we describe two classes of bulbar neurons, off-on, which are silent but exhibit a 80 ± 56 Hz firing discharge at the beginning of (and during) the OSP, and on-off interneurons, with a 27 ± 14 Hz firing activity that stops at the beginning of (and during) the OSP. We suggest that these OSP-associated neurons belong to a descending RAS, which contributes to the activation of the spinal central pattern generators.

  11. A model of a flexible anguilliform swimmer driven by a central pattern generator with proprioceptive feedback

    Science.gov (United States)

    Hamlet, Christina; Tytell, Eric; Hoffman, Kathleen; Fauci, Lisa

    2015-11-01

    The swimming of a simple vertebrate, the lamprey, can shed light on how a flexible body can couple with a fluid environment to swim rapidly and efficiently. Animals use proprioceptive sensory information to sense how their bodies are bending, and then adjust the neural signals to their muscles to improve performance. We will present recent progress in the development of a computational model of a lamprey swimming in a Navier-Stokes fluid where a simple central pattern generator model, based on phase oscillators, is coupled to the evolving body dynamics of the swimmer through curvature and curvature derivative feedback. Such feedback can be positive (frequency decreasing), negative (frequency increasing), or mixed (positive to one side of the body and negative to the other, or vice versa). We will examine how the emergent swimming behavior and cost of transport depends upon these functional forms of proprioceptive feedback chosen in the model.

  12. Intersegmental coordination of cockroach locomotion: adaptive control of centrally coupled pattern generator circuits

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    Einat eFuchs

    2011-01-01

    Full Text Available Animals’ ability to demonstrate both stereotyped and adaptive locomotor behavior is largely dependent on the interplay between centrally-generated motor patterns and the sensory inputs that shape them. We utilized a combined experimental and theoretical approach to investigate the relative importance of CPG interconnections vs. intersegmental afferents in the cockroach: an animal that is renowned for rapid and stable locomotion. We simultaneously recorded coxal levator and depressor motor neurons (MN in the thoracic ganglia of Periplaneta americana, while sensory feedback was completely blocked or allowed only from one intact stepping leg. In the absence of sensory feedback, we observed a coordination pattern with consistent phase relationship that shares similarities with a double tripod gait, suggesting central, feedforward control. This intersegmental coordination pattern was then reinforced in the presence of sensory feedback from a single stepping leg. Specifically, we report on transient stabilization of phase differences between activity recorded in the middle and hind thoracic MN following individual front-leg steps, suggesting a role for afferent phasic information in the coordination of motor circuits at the different hemiganglia. Data were further analyzed using stochastic models of coupled oscillators and maximum likelihood techniques to estimate underlying physiological parameters, such as uncoupled endogenous frequencies of hemisegmental oscillators and coupling strengths and directions. We found that descending ipsilateral coupling is stronger than ascending coupling, while left-right coupling in both the meso- and meta-thoracic ganglia appear to be symmetrical. We discuss our results in comparison with recent findings in stick insects that share similar neural and body architectures, and argue that the two species may exemplify opposite extremes of a fast-slow locomotion continuum, mediated through different intersegmental

  13. The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm.

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    Tazerart, Sabrina; Vinay, Laurent; Brocard, Frédéric

    2008-08-20

    Rhythm generation in neuronal networks relies on synaptic interactions and pacemaker properties. Little is known about the contribution of the latter mechanisms to the integrated network activity underlying locomotion in mammals. We tested the hypothesis that the persistent sodium current (I(NaP)) is critical in generating locomotion in neonatal rodents using both slice and isolated spinal cord preparations. After removing extracellular calcium, 75% of interneurons in the area of the central pattern generator (CPG) for locomotion exhibited bursting properties and I(NaP) was concomitantly upregulated. Putative CPG interneurons such as commissural and Hb9 interneurons also expressed I(NaP)-dependent (riluzole-sensitive) bursting properties. Most bursting cells exhibited a pacemaker-like behavior (i.e., burst frequency increased with depolarizing currents). Veratridine upregulated I(NaP), induced riluzole-sensitive bursting properties, and slowed down the locomotor rhythm. This study provides evidence that I(NaP) generates pacemaker activities in CPG interneurons and contributes to the regulation of the locomotor activity.

  14. Symmetry-Breaking in a Rate Model for a Biped Locomotion Central Pattern Generator

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    Ian Stewart

    2014-01-01

    Full Text Available The timing patterns of animal gaits are produced by a network of spinal neurons called a Central Pattern Generator (CPG. Pinto and Golubitsky studied a four-node CPG for biped dynamics in which each leg is associated with one flexor node and one extensor node, with Ζ2 x Ζ2 symmetry. They used symmetric bifurcation theory to predict the existence of four primary gaits and seven secondary gaits. We use methods from symmetric bifurcation theory to investigate local bifurcation, both steady-state and Hopf, for their network architecture in a rate model. Rate models incorporate parameters corresponding to the strengths of connections in the CPG: positive for excitatory connections and negative for inhibitory ones. The three-dimensional space of connection strengths is partitioned into regions that correspond to the first local bifurcation from a fully symmetric equilibrium. The partition is polyhedral, and its symmetry group is that of a tetrahedron. It comprises two concentric tetrahedra, subdivided by various symmetry planes. The tetrahedral symmetry arises from the structure of the eigenvalues of the connection matrix, which is involved in, but not equal to, the Jacobian of the rate model at bifurcation points. Some of the results apply to rate equations on more general networks.

  15. Analysis and modeling of the locomotor central pattern generator as a network of coupled oscillators.

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    Sigvardt, K A; Miller, W L

    1998-11-16

    The primary functions of spinal locomotor central pattern generators (CPGs) are to provide oscillatory motor commands to individual joints or segments and to control the precise timing of those commands across all joints or segments for efficient, coordinated locomotor behavior. Our ability to understand the neuronal mechanisms underlying intersegmental coordination has been hampered by the complexity of propriospinal interconnectivity and the paucity of quantitative data on the magnitude and timing of those connections. Theoretical approaches have therefore been employed to discover general rules by which CPG-like oscillator systems must be constructed to produce appropriate coordinated locomotor behavior; the locomotor CPG is represented as a network of oscillators, where each oscillator generates local motor output and interoscillator coupling provides intersegmental coordination. Mathematical analysis of such coupled oscillator systems has provided a number of experimentally testable predictions regarding the link between coupling and coordination. Application of these network-level predictions to the results of electrophysiological experiments has required data analysis methods that can relate the behavior of the in vitro spinal cord to the variables employed by the mathematical model. Hence, our most recent work has focused on developing analytic tools for quantifying the changes in locomotor output that result form experimental manipulations of the propriospinal system in terms of frequency, intersegmental phase, and intersegmental correlation. Results of recent experiments can now be used to put further constraints on the allowable kinds of intersegmental coupling provided by mathematical modeling of the system.

  16. Modeling neural mechanisms for genesis of respiratory rhythm and pattern. II. Network models of the central respiratory pattern generator.

    Science.gov (United States)

    Rybak, I A; Paton, J F; Schwaber, J S

    1997-04-01

    The present paper describes several models of the central respiratory pattern generator (CRPG) developed employing experimental data and current hypotheses for respiratory rhythmogenesis. Each CRPG model includes a network of respiratory neuron types (e.g., early inspiratory; ramp inspiratory; late inspiratory; decrementing expiratory; postinspiratory; stage II expiratory; stage II constant firing expiratory; preinspiratory) and simplified models of lung and pulmonary stretch receptors (PSR), which provide feedback to the respiratory network. The used models of single respiratory neurons were developed in the Hodgkin-Huxley style as described in the previous paper. The mechanism for termination of inspiration (the inspiratory off-switch) in all models operates via late-I neuron, which is considered to be the inspiratory off-switching neuron. Several two- and three-phase CRPG models have been developed using different accepted hypotheses of the mechanism for termination of expiration. The key elements in the two-phase models are the early-I and dec-E neurons. The expiratory off-switch mechanism in these models is based on the mutual inhibitory connections between early-I and dec-E and adaptive properties of the dec-E neuron. The difference between the two-phase models concerns the mechanism for ramp firing patterns of E2 neurons resulting either from the intrinsic neuronal properties of the E2 neuron or from disinhibition from the adapting dec-E neuron. The key element of the three-phase models is the pre-I neuron, which acts as the expiratory off-switching neuron. The three-phase models differ by the mechanisms used for termination of expiration and for the ramp firing patterns of E2 neurons. Additional CRPG models were developed employing a dual switching neuron that generates two bursts per respiratory cycle to terminate both inspiration and expiration. Although distinctly different each model generates a stable respiratory rhythm and shows physiologically

  17. A modeling approach on why simple central pattern generators are built of irregular neurons.

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    Marcelo Bussotti Reyes

    Full Text Available The crustacean pyloric Central Pattern Generator (CPG is a nervous circuit that endogenously provides periodic motor patterns. Even after about 40 years of intensive studies, the rhythm genesis is still not rigorously understood in this CPG, mainly because it is made of neurons with irregular intrinsic activity. Using mathematical models we addressed the question of using a network of irregularly behaving elements to generate periodic oscillations, and we show some advantages of using non-periodic neurons with intrinsic behavior in the transition from bursting to tonic spiking (as found in biological pyloric CPGs as building components. We studied two- and three-neuron model CPGs built either with Hindmarsh-Rose or with conductance-based Hodgkin-Huxley-like model neurons. By changing a model's parameter we could span the neuron's intrinsic dynamical behavior from slow periodic bursting to fast tonic spiking, passing through a transition where irregular bursting was observed. Two-neuron CPG, half center oscillator (HCO, was obtained for each intrinsic behavior of the neurons by coupling them with mutual symmetric synaptic inhibition. Most of these HCOs presented regular antiphasic bursting activity and the changes of the bursting frequencies was studied as a function of the inhibitory synaptic strength. Among all HCOs, those made of intrinsic irregular neurons presented a wider burst frequency range while keeping a reliable regular oscillatory (bursting behavior. HCOs of periodic neurons tended to be either hard to change their behavior with synaptic strength variations (slow periodic burster neurons or unable to perform a physiologically meaningful rhythm (fast tonic spiking neurons. Moreover, 3-neuron CPGs with connectivity and output similar to those of the pyloric CPG presented the same results.

  18. A modeling approach on why simple central pattern generators are built of irregular neurons.

    Science.gov (United States)

    Reyes, Marcelo Bussotti; Carelli, Pedro Valadão; Sartorelli, José Carlos; Pinto, Reynaldo Daniel

    2015-01-01

    The crustacean pyloric Central Pattern Generator (CPG) is a nervous circuit that endogenously provides periodic motor patterns. Even after about 40 years of intensive studies, the rhythm genesis is still not rigorously understood in this CPG, mainly because it is made of neurons with irregular intrinsic activity. Using mathematical models we addressed the question of using a network of irregularly behaving elements to generate periodic oscillations, and we show some advantages of using non-periodic neurons with intrinsic behavior in the transition from bursting to tonic spiking (as found in biological pyloric CPGs) as building components. We studied two- and three-neuron model CPGs built either with Hindmarsh-Rose or with conductance-based Hodgkin-Huxley-like model neurons. By changing a model's parameter we could span the neuron's intrinsic dynamical behavior from slow periodic bursting to fast tonic spiking, passing through a transition where irregular bursting was observed. Two-neuron CPG, half center oscillator (HCO), was obtained for each intrinsic behavior of the neurons by coupling them with mutual symmetric synaptic inhibition. Most of these HCOs presented regular antiphasic bursting activity and the changes of the bursting frequencies was studied as a function of the inhibitory synaptic strength. Among all HCOs, those made of intrinsic irregular neurons presented a wider burst frequency range while keeping a reliable regular oscillatory (bursting) behavior. HCOs of periodic neurons tended to be either hard to change their behavior with synaptic strength variations (slow periodic burster neurons) or unable to perform a physiologically meaningful rhythm (fast tonic spiking neurons). Moreover, 3-neuron CPGs with connectivity and output similar to those of the pyloric CPG presented the same results.

  19. The Contribution of a Central Pattern Generator in a Reflex-Based Neuromuscular Model

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    Florin eDzeladini

    2014-06-01

    Full Text Available Although the concept of central pattern generators (CPGs controlling locomotion in vertebrates is widely accepted, the presence of specialized CPGs in human locomotion is still a matter of debate. An interesting numerical model developed in the 90s' demonstrated the important role CPGs could play in human locomotion, both in terms of stability against perturbations, and in terms of speed control. Recently, a reflex-based neuro-musculo-skeletal model has been proposed, showing a level of stability to perturbations similar to the previous model, without any CPG components. Although exhibiting striking similarities with human gaits, the lack of CPG makes the control of speed/step length in the model difficult. In this paper, we hypothesize that a CPG component will offer a meaningful way of controlling the locomotion speed. After introducing the CPG component in the reflex model, and taking advantage of the resulting properties, a simple model for gait modulation is presented.The results highlight the advantages that a feedforward component can have in terms of gait modulation.

  20. Setting the pace: new insights into central pattern generator interactions in box jellyfish swimming.

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    Anna Lisa Stöckl

    Full Text Available Central Pattern Generators (CPGs produce rhythmic behaviour across all animal phyla. Cnidarians, which have a radially symmetric nervous system and pacemaker centres in multiples of four, provide an interesting comparison to bilaterian animals for studying the coordination between CPGs. The box jellyfish Tripedalia cystophora is remarkable among cnidarians due to its most elaborate visual system. Together with their ability to actively swim and steer, they use their visual system for multiple types of behaviour. The four swim CPGs are directly regulated by visual input. In this study, we addressed the question of how the four pacemaker centres of this radial symmetric cnidarian interact. We based our investigation on high speed camera observations of the timing of swim pulses of tethered animals (Tripedalia cystophora with one or four rhopalia, under different simple light regimes. Additionally, we developed a numerical model of pacemaker interactions based on the inter pulse interval distribution of animals with one rhopalium. We showed that the model with fully resetting coupling and hyperpolarization of the pacemaker potential below baseline fitted the experimental data best. Moreover, the model of four swim pacemakers alone underscored the proportion of long inter pulse intervals (IPIs considerably. Both in terms of the long IPIs as well as the overall swim pulse distribution, the simulation of two CPGs provided a better fit than that of four. We therefore suggest additional sources of pacemaker control than just visual input. We provide guidelines for future research on the physiological linkage of the cubozoan CPGs and show the insight from bilaterian CPG research, which show that pacemakers have to be studied in their bodily and nervous environment to capture all their functional features, are also manifest in cnidarians.

  1. Real-time biomimetic Central Pattern Generators into FPGA for hybrid experiments

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    Matthieu eAmbroise

    2013-11-01

    Full Text Available This article investigates the neural network system in the leech heartbeat and develops a real-time biomimetic digital hardware using few-resource implementation for hybrid experiments. The leech heartbeat neural network is one of the most simple central pattern generators (CPG. In biology, CPG provide for rhythmic bursts of spikes and is the basis for all muscles contractions orders (heartbeat and locomotion (walking, running….. The leech neural network system was already investigated and this CPG has been already formalized with Hodgkin-Huxley neural model (HH that is the most complex neuron model. However, the resources needed for a neural model is proportional to its complexity. To answer to this issue, this article describes a biomimetic implementation into FPGA (Field Programmable Gate Array of a network of 240 CPGs using a simple model (Izhikevich model and by proposing a new synapse model: activity dependent depression synapse. The architecture of the network implementation allows working on a single computation core. This digital system works in real-time, needs few resources and has the same bursting activity behavior than complex model. To validate our implementation of this CPG, we compare it firstly with a simulation of the complex model. Then we match its activity with the pharmacological data of the activity of the rat’s spinal cord. This digital system allows future hybrid experiments and will be a great step towards hybridation between biological tissue and artificial neural network. This network of CPG could be also useful for mimic the activity of a different animal locomotion or developing hybrid experiments for neuroprosthesis development.

  2. Real-time biomimetic Central Pattern Generators in an FPGA for hybrid experiments.

    Science.gov (United States)

    Ambroise, Matthieu; Levi, Timothée; Joucla, Sébastien; Yvert, Blaise; Saïghi, Sylvain

    2013-01-01

    This investigation of the leech heartbeat neural network system led to the development of a low resources, real-time, biomimetic digital hardware for use in hybrid experiments. The leech heartbeat neural network is one of the simplest central pattern generators (CPG). In biology, CPG provide the rhythmic bursts of spikes that form the basis for all muscle contraction orders (heartbeat) and locomotion (walking, running, etc.). The leech neural network system was previously investigated and this CPG formalized in the Hodgkin-Huxley neural model (HH), the most complex devised to date. However, the resources required for a neural model are proportional to its complexity. In response to this issue, this article describes a biomimetic implementation of a network of 240 CPGs in an FPGA (Field Programmable Gate Array), using a simple model (Izhikevich) and proposes a new synapse model: activity-dependent depression synapse. The network implementation architecture operates on a single computation core. This digital system works in real-time, requires few resources, and has the same bursting activity behavior as the complex model. The implementation of this CPG was initially validated by comparing it with a simulation of the complex model. Its activity was then matched with pharmacological data from the rat spinal cord activity. This digital system opens the way for future hybrid experiments and represents an important step toward hybridization of biological tissue and artificial neural networks. This CPG network is also likely to be useful for mimicking the locomotion activity of various animals and developing hybrid experiments for neuroprosthesis development.

  3. Belly dancer's myoclonus and chronic abdominal pain: pain-related dysinhibition of a spinal cord central pattern generator?

    Science.gov (United States)

    Tamburin, Stefano; Idone, Domenico; Zanette, Giampietro

    2007-07-01

    We report on a patient with segmental rhythmic myoclonus resembling belly dance. This patient developed the myoclonus in temporal and anatomical association with chronic abdominal pain. No structural or metabolic abnormalities were found. EMG recordings suggested the presence of a spinal cord central pattern generator (CPG). We hypothesize that pain-related spinal plasticity might have contributed to the hyperactivity of a spinal CPG, thus leading to the myoclonic jerks in our patient.

  4. Organisation of the spinal central pattern generators for locomotion in the salamander: biology and modelling.

    Science.gov (United States)

    Chevallier, Stéphanie; Jan Ijspeert, Auke; Ryczko, Dimitri; Nagy, Frédéric; Cabelguen, Jean-Marie

    2008-01-01

    Among living tetrapods, salamanders are regarded as most closely resembling the first terrestrial vertebrates, and are therefore an interesting group in which the evolutionary changes in the locomotor behaviour from aquatic to terrestrial habitats can be inferred. Salamanders exhibit two locomotor modes: swimming and terrestrial stepping. The swimming is anguilliform and resembles closely that of the lamprey. On the ground, the salamander switches to a stepping gait with axial undulations that is also observed in many reptiles. The salamander is therefore ideally suited for examining the neural mechanisms for the generation of these two locomotor modes, as well as the neural mechanisms of gait transition. In the present paper, we describe the kinematics and patterns of activation of axial and limb muscles during stepping and swimming in adult salamanders. We then review the current neurobiological data about the organisation of the spinal networks underlying swimming and stepping, and the mechanisms of gait transition. Finally we report modelling studies aimed at understanding the organisation and operation of the salamander locomotor circuits. Altogether, the neurobiological and the modelling data support the hypothesis of a phylogenetic conservatism from agnathians to amphibians of the spinal locomotor networks generating axial motor patterns.

  5. Design of Spiking Central Pattern Generators for Multiple Locomotion Gaits in Hexapod Robots by Christiansen Grammar Evolution.

    Science.gov (United States)

    Espinal, Andres; Rostro-Gonzalez, Horacio; Carpio, Martin; Guerra-Hernandez, Erick I; Ornelas-Rodriguez, Manuel; Sotelo-Figueroa, Marco

    2016-01-01

    This paper presents a method to design Spiking Central Pattern Generators (SCPGs) to achieve locomotion at different frequencies on legged robots. It is validated through embedding its designs into a Field-Programmable Gate Array (FPGA) and implemented on a real hexapod robot. The SCPGs are automatically designed by means of a Christiansen Grammar Evolution (CGE)-based methodology. The CGE performs a solution for the configuration (synaptic weights and connections) for each neuron in the SCPG. This is carried out through the indirect representation of candidate solutions that evolve to replicate a specific spike train according to a locomotion pattern (gait) by measuring the similarity between the spike trains and the SPIKE distance to lead the search to a correct configuration. By using this evolutionary approach, several SCPG design specifications can be explicitly added into the SPIKE distance-based fitness function, such as looking for Spiking Neural Networks (SNNs) with minimal connectivity or a Central Pattern Generator (CPG) able to generate different locomotion gaits only by changing the initial input stimuli. The SCPG designs have been successfully implemented on a Spartan 6 FPGA board and a real time validation on a 12 Degrees Of Freedom (DOFs) hexapod robot is presented.

  6. Stable Walking of Humanoid Robots Using Vertical Center of Mass and Foot Motions by an Evolutionary Optimized Central Pattern Generator

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    Young-Dae Hong

    2016-02-01

    Full Text Available This paper proposes a method to produce the stable walking of humanoid robots by incorporating the vertical center of mass (COM and foot motions, which are generated by the evolutionary optimized central pattern generator (CPG, into the modifiable walking pattern generator (MWPG. The MWPG extends the conventional 3-D linear inverted pendulum model (3-D LIPM by allowing a zero moment point (ZMP variation. The disturbance caused by the vertical COM motion is compensated in real time by the sensory feedback in the CPG. In this paper, the vertical foot trajectory of the swinging leg, as well as the vertical COM trajectory of the 3-D LIPM, are generated by the CPG for the effective compensation of the disturbance. Consequently, using the proposed method, the humanoid robot is able to walk with a vertical COM and the foot motions generated by the CPG, while modifying its walking patterns by using the MWPG in real time. The CPG with the sensory feedback is optimized to obtain the desired output signals. The optimization of the CPG is formulated as a constrained optimization problem with equality constraints and is solved by two-phase evolutionary programming (TPEP. The validity of the proposed method is verified through walking experiments for the small-sized humanoid robot, HanSaRam-IX (HSR-IX.

  7. Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients

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    Pierre eGuertin

    2014-05-01

    Full Text Available Ambulation or walking is one of the main gaits of locomotion. In terrestrial animals, it may be defined as a series of rhythmic and bilaterally coordinated movement of the limbs which creates a forward movement of the body. This applies regardless of the number of limbs - from arthropods with six or more limbs to bipedal primates. These fundamental similarities among species may explain why comparable neural systems and cellular properties have been found, thus far, to control in similar ways locomotor rhythm generation in most animal models. The aim of this article is to provide a comprehensive review of the known structural and functional features associated with central nervous system (CNS networks that are involved in the control of ambulation and other stereotyped motor patterns - specifically Central Pattern Generators (CPGs that produce basic rhythmic patterned outputs for locomotion, micturition, ejaculation, and defecation. Although there is compelling evidence of their existence in humans, CPGs have been most studied in reduced models including in vitro isolated preparations, genetically-engineered mice and spinal cord-transected animals. Compared with other structures of the CNS, the spinal cord is generally considered as being well-preserved phylogenetically. As such, most animal models of SCI should be considered as valuable tools for the development of novel pharmacological strategies aimed at modulating spinal activity and restoring corresponding functions in chronic spinal cord-injured patients.

  8. Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system.

    Science.gov (United States)

    Molkov, Yaroslav I; Zoccal, Daniel B; Baekey, David M; Abdala, Ana P L; Machado, Benedito H; Dick, Thomas E; Paton, Julian F R; Rybak, Ilya A

    2014-01-01

    Respiratory modulation seen in the sympathetic nerve activity (SNA) implies that the respiratory and sympathetic networks interact. During hypertension elicited by chronic intermittent hypoxia (CIH), the SNA displays an enhanced respiratory modulation reflecting strengthened interactions between the networks. In this chapter, we review a series of experimental and modeling studies that help elucidate possible mechanisms of sympatho-respiratory coupling. We conclude that this coupling significantly contributes to both the sympathetic baroreflex and the augmented sympathetic activity after exposure to CIH. This conclusion is based on the following findings. (1) Baroreceptor activation results in perturbation of the respiratory pattern via transient activation of postinspiratory neurons in the Bötzinger complex (BötC). The same BötC neurons are involved in the respiratory modulation of SNA, and hence provide an additional pathway for the sympathetic baroreflex. (2) Under hypercapnia, phasic activation of abdominal motor nerves (AbN) is accompanied by synchronous discharges in SNA due to the common source of this rhythmic activity in the retrotrapezoid nucleus (RTN). CIH conditioning increases the CO2 sensitivity of central chemoreceptors in the RTN which results in the emergence of AbN and SNA discharges under normocapnic conditions similar to those observed during hypercapnia in naïve animals. Thus, respiratory-sympathetic interactions play an important role in defining sympathetic output and significantly contribute to the sympathetic activity and hypertension under certain physiological or pathophysiological conditions, and the theoretical framework presented may be instrumental in understanding of malfunctioning control of sympathetic activity in a variety of disease states.

  9. Monoaminergic and catecholaminergic activation of the central pattern generator for locomotion following spinal cord injury Innovative therapeutic approaches

    Institute of Scientific and Technical Information of China (English)

    Pierre A.Guertin

    2009-01-01

    The development of secondary health complications following spinal cord injury has been increasingly recognized by healthcare professionals as a major concern.These problems most specifically affect complete or near-complete spinal cord injury patients (e.g.,those with minimal mobility),who are not typically rehabilitated with treadmill training approaches,because motor control and leg movements are largely impaired.However,recent pharmaceutical advances in central pattern generator activation may provide new therapeutic hopes for these spinal cord injury patients.This article provides a comprehensive overview,for the non-specialist,of the most recent advances in this field.

  10. Evidence of a central pattern generator regulating spermathecal muscle activity in Locusta migratoria and its coordination with oviposition.

    Science.gov (United States)

    da Silva, Rosa; Lange, Angela B

    2011-03-01

    Electrophysiological recordings were conducted to determine the control of spermathecal contractions during oviposition of interrupted egg-laying locusts, Locusta migratoria. Following transection of the central nervous system below the metathoracic ganglion, rhythmic patterned bursting was detected by extracellular recordings of the nerve N2B2 that innervates the muscles of the spermatheca. Subsequent transections at more posterior regions of the ventral nerve cord revealed more robust rhythmic bursting in N2B2. This rhythmic bursting pattern was found to be coordinated with bursting in the ventral opener nerve (N2B1) that innervates the ventral opener muscle. This muscle controls the ventral ovipositor valves. Electromyographic recordings from the spermathecal muscle and ventral opener muscle confirmed a rhythmic bursting pattern resulting in an increase in muscle activity. Taken together, the results indicate that there is probably a central pattern generator (CPG), which is regulated by descending inhibition, that controls the spermathecal muscle activity. This CPG appears to be located within the VIIth and VIIIth abdominal ganglia, and was found to integrate with the CPG that regulates oviposition digging in locusts. These results provide further insight into the intricate coordination and control of reproductive tissues underlying reproductive behaviours in locusts.

  11. Central pattern generators for a common semiology in fronto-limbic seizures and in parasomnias. A neuroethologic approach.

    Science.gov (United States)

    Tassinari, C A; Rubboli, G; Gardella, E; Cantalupo, G; Calandra-Buonaura, G; Vedovello, M; Alessandria, M; Gandini, G; Cinotti, S; Zamponi, N; Meletti, S

    2005-12-01

    Central pattern generators (CPGs) are genetically determined neuronal aggregates in the mesencephalon, pons and spinal cord subserving innate motor behaviours essential for survival (feeding, locomotion, reproduction etc.). In higher primates CPGs are largely under neocortical control. We describe how certain motor events observed in parasomnias and epileptic seizures could have similar features and resemble motor behaviours, which can be the expression of the same CPG. Both epilepsy and sleep can lead to a temporary loss of control of neomammalian cortex that facilitates through a common platform (arousal) the emergences of stereotyped inborn fixed action patterns. Therefore we suggest that, independently from the nature of the trigger, be it a seizure or a parasomnia, the same CPGs can be involved, "caught up", leading to a common motor semiology (the "Carillon theory").

  12. Closing the Loop: Integrating Body, Muscle and Environment with Locomotion Central Pattern Generators

    Science.gov (United States)

    2013-06-30

    simple closed-loop model in which a CPG produces a pattern of muscle activation which is modified by sensory feedback related to body curvature . (a...by a complex interaction of the neural circuits in the spinal cord and brain, the body, the muscles, sensory organs and the environment. With- out...feedback related to body curvature . 2.1 Computation of optimal feedback for the control of locomotion We have a developed a general method of computing

  13. Design of Spiking Central Pattern Generators for Multiple Locomotion Gaits in Hexapod Robots by Christiansen Grammar Evolution

    Directory of Open Access Journals (Sweden)

    Andrés Espinal

    2016-07-01

    Full Text Available This paper deals with the design of Spiking Central Pattern Generators (SCPGs to achieve locomotion at different frequencies in legged robots and their hardware implementation in a FPGA and validation on a real hexapod robot. Herein, the SCPGs are automatically designed by a Christiansen Grammar Evolution (CGE-based methodology. It is, the CGE performs a solution for the configurations (synaptic weights and connections of each neuron in the SCPG. This is carried out through the indirect representation of a candidate solution that evolves to replicate a specific spike train according to a locomotion pattern (gait by measuring the similarity between the spike train with the SPIKE-Distance to drive the search to a correct configuration. By using this evolutionary approach, several SCPG design specifications can be explicitly added into the fitness function to achieve the SPIKE-distance criteria, such as: looking for SNNs with minimal connectivity or a CPG able to generate different locomotion gaits only by changing the initial input stimuli. The SCPG designs have been successfully implemented on a Spartan 6 FPGA board and a real time validation on a 12 DOFs hexapod robot is presented.

  14. Exercise, music, and the brain: is there a central pattern generator?

    Science.gov (United States)

    Schneider, Stefan; Askew, Christopher D; Abel, Thomas; Strüder, Heiko K

    2010-10-01

    The frequency for movements along the longitudinal axis during running peaks at approximately 3 Hz. Other physiological systems (e.g. heart rate and brain cortical activity) are known to show a dominant frequency of ~3 Hz connected to exercise. As recent studies have proposed a clear correlation between musical tempo, mood, and performance output, we wished to ascertain whether peak locomotion frequency of ~3 Hz during running is synchronized with different intrinsic and extrinsic frequencies. Eighteen healthy regular runners performed three outdoor running sessions at different intensities. Oscillations along the longitudinal axis were recorded using an accelerometer (ActiBelt). Electrocortical activity was recorded using electroencephalography before and after exercise and analysed in the delta frequency range (2-4 Hz). In addition, the frequency spectra of the participants' favourite musical pieces were analysed. Data revealed a peak frequency at around 2.7 to 2.8 Hz for the vertical acceleration during running. Similar oscillation patterns were found for heart rate and musical pieces. Electroencephalographic delta activity increased after running. Results of this study give reason to speculate that a strong relationship exists between intrinsic and extrinsic oscillation patterns during exercise. A frequency of approximately 3 Hz seems to be dominant in different physiological systems and seems to be rated as pleasurable when choosing the appropriate music for exercising. This is in line with previous research showing that an adequate choice of music during exercise enhances performance output and mood.

  15. Multiple Chaotic Central Pattern Generators with Learning for Legged Locomotion and Malfunction Compensation

    DEFF Research Database (Denmark)

    Ren, Guanjiao; Chen, Weihai; Dasgupta, Sakyasingha

    2015-01-01

    on a simulated annealing algorithm. In a normal situation, the CPGs synchronize and their dynamics are identical. With leg malfunction or disability, the CPGs lose synchronization leading to independent dynamics. In this case, the learning mechanism is applied to automatically adjust the remaining legs...... chaotic CPG controller has difficulties dealing with leg malfunction. Specifically, in the scenarios presented here, its movement permanently deviates from the desired trajectory. To address this problem, we extend the single chaotic CPG to multiple CPGs with learning. The learning mechanism is based...... in a physical simulation of a quadruped as well as a hexapod robot and finally in a real six-legged walking machine called AMOSII. The experimental results presented here reveal that using multiple CPGs with learning is an effective approach for adaptive locomotion generation where, for instance, different body...

  16. Control of oscillation periods and phase durations in half-center central pattern generators: a comparative mechanistic analysis.

    Science.gov (United States)

    Daun, Silvia; Rubin, Jonathan E; Rybak, Ilya A

    2009-08-01

    Central pattern generators (CPGs) consisting of interacting groups of neurons drive a variety of repetitive, rhythmic behaviors in invertebrates and vertebrates, such as arise in locomotion, respiration, mastication, scratching, and so on. These CPGs are able to generate rhythmic activity in the absence of afferent feedback or rhythmic inputs. However, functionally relevant CPGs must adaptively respond to changing demands, manifested as changes in oscillation period or in relative phase durations in response to variations in non-patterned inputs or drives. Although many half-center CPG models, composed of symmetric units linked by reciprocal inhibition yet varying in their intrinsic cellular properties, have been proposed, the precise oscillatory mechanisms operating in most biological CPGs remain unknown. Using numerical simulations and phase-plane analysis, we comparatively investigated how the intrinsic cellular features incorporated in different CPG models, such as subthreshold activation based on a slowly inactivating persistent sodium current, adaptation based on slowly activating calcium-dependent potassium current, or post-inhibitory rebound excitation, can contribute to the control of oscillation period and phase durations in response to changes in excitatory external drive to one or both half-centers. Our analysis shows that both the sensitivity of oscillation period to alterations of excitatory drive and the degree to which the duration of each phase can be separately controlled depend strongly on the intrinsic cellular mechanisms involved in rhythm generation and phase transitions. In particular, the CPG formed from units incorporating a slowly inactivating persistent sodium current shows the greatest range of oscillation periods and the greatest degree of independence in phase duration control by asymmetric inputs. These results are explained based on geometric analysis of the phase plane structures corresponding to the dynamics for each CPG type

  17. A novel approach to locomotion learning: Actor-Critic architecture using central pattern generators and dynamic motor primitives.

    Science.gov (United States)

    Li, Cai; Lowe, Robert; Ziemke, Tom

    2014-01-01

    In this article, we propose an architecture of a bio-inspired controller that addresses the problem of learning different locomotion gaits for different robot morphologies. The modeling objective is split into two: baseline motion modeling and dynamics adaptation. Baseline motion modeling aims to achieve fundamental functions of a certain type of locomotion and dynamics adaptation provides a "reshaping" function for adapting the baseline motion to desired motion. Based on this assumption, a three-layer architecture is developed using central pattern generators (CPGs, a bio-inspired locomotor center for the baseline motion) and dynamic motor primitives (DMPs, a model with universal "reshaping" functions). In this article, we use this architecture with the actor-critic algorithms for finding a good "reshaping" function. In order to demonstrate the learning power of the actor-critic based architecture, we tested it on two experiments: (1) learning to crawl on a humanoid and, (2) learning to gallop on a puppy robot. Two types of actor-critic algorithms (policy search and policy gradient) are compared in order to evaluate the advantages and disadvantages of different actor-critic based learning algorithms for different morphologies. Finally, based on the analysis of the experimental results, a generic view/architecture for locomotion learning is discussed in the conclusion.

  18. A Novel Approach to Locomotion Learning: Actor-Critic Architecture using Central Pattern Generators and Dynamic Motor Primitives

    Directory of Open Access Journals (Sweden)

    Cai eLi

    2014-10-01

    Full Text Available In this article, we propose an architecture of a bio-inspired controller that addresses the problem of learning different locomotion gaits for different robot morphologies. The modelling objective is split into two: baseline motion modelling and dynamics adaptation. Baseline motion modelling aims to achieve fundamental functions of a certain type of locomotion and dynamics adaptation provides a ``reshaping function for adapting the baseline motion to desired motion. Based on this assumption, a three-layer architecture is developed using central pattern generators (CPGs, a bio-inspired locomotor center for the the baseline motion and dynamic motor primitives (DMPs, a model with universal ``reshaping functions. In this article, we use this architecture with the actor-critic algorithms for finding a good ``reshaping function. In order to demonstrate the learning power of the actor-critic based architecture, we tested it on two experiments: 1 learning to crawl on a humanoid and, 2 learning to gallop on a puppy robot. Two types of actor-critic algorithms (policy search and policy gradient are compared in order to evaluate the advantages and disadvantages of different actor-critic based learning algorithms for different morphologies. Finally, based on the analysis of the experimental results, a generic view/architecture for locomotion learning is discussed in the conclusion.

  19. Neuroethological approach to frontolimbic epileptic seizures and parasomnias: The same central pattern generators for the same behaviours.

    Science.gov (United States)

    Tassinari, C A; Cantalupo, G; Högl, B; Cortelli, P; Tassi, L; Francione, S; Nobili, L; Meletti, S; Rubboli, G; Gardella, E

    2009-10-01

    The aim of this report is not to make a differential diagnosis between epileptic nocturnal seizures and non-epileptic sleep-related movement disorders, or parasomnias. On the contrary, our goal is to emphasize the commonly shared semiological features of some epileptic seizures and parasomnias. Such similar features might be explained by the activation of the same neuronal networks (so-called 'central pattern generators' or CPG). These produce the stereotypical rhythmic motor sequences - in other words, behaviours - that are adaptive and species-specific (such as eating/alimentary, attractive/aversive, locomotor and nesting habits). CPG are located at the subcortical level (mainly in the brain stem and spinal cord) and, in humans, are under the control of the phylogenetically more recent neomammalian neocortical structures, according to a simplified Jacksonian model. Based on video-polygraphic recordings of sleep-related epileptic seizures and non-epileptic events (parasomnias), we have documented how a transient "neomammalian brain" dysfunction - whether epileptic or not - can 'release' (disinhibition?) the CPG responsible for involuntary motor behaviours. Thus, in both epileptic seizures and parasomnias, we can observe: (a) oroalimentary automatisms, bruxism and biting; (b) ambulatory behaviours, ranging from the classical bimanual-bipedal activity of 'frontal' hypermotor seizures, epileptic and non-epileptic wanderings, and somnambulism to periodic leg movements (PLM), alternating leg muscle activation (ALMA) and restless legs syndrome (RLS); and (c) various sleep-related events such as ictal fear, sleep terrors, nightmares and violent behaviour.

  20. Simulation Platform of Underwater Quadruped Walking Robot Based on MotionGenesis Kane 5 3 and Central Pattern Generator

    Institute of Scientific and Technical Information of China (English)

    Ke Yang; XuYang Wang; Tong Ge; Chao Wu

    2014-01-01

    It will still in lack of a simulation platform used to learn the walking of underwater quadruped walking robot. In order to alleviate this shortage, a simulation platform for the underwater quadruped walking robot based on Kane dynamic model and CPG-based controller is constructed. The Kane dynamic model of the underwater quadruped walking robot is processed with a commercial package MotionGenesis Kane 5�3. The forces between the feet and ground are represented as a spring and damper. The relation between coefficients of spring and damper and stability of underwater quadruped walking robot in the stationary state is studied. The CPG-based controller consisted of Central Pattern Generator ( CPG) and PD controller is presented, which can be used to control walking of the underwater quadruped walking robot. The relation between CPG parameters and walking speed of underwater quadruped walking robot is investigated. The relation between coefficients of spring and damper and walking speed of underwater quadruped walking robot is studied. The results show that the simulation platform can imitate the stable walking of the underwater quadruped walking robot.

  1. Evolution of central pattern generators for the control of a five-link planar bipedal walking mechanism

    CERN Document Server

    Baydin, Atilim Gunes

    2008-01-01

    With the aim of producing a stable human-like bipedal gait, a five-link planar walking mechanism was coupled with a central pattern generator (CPG) network, consisting of units based on Matsuoka's half-center oscillator model. As a minimalistic approach to bipedal walking, this type of walking mechanism contains only four actuators (two in the hip joints and two in the knee joints), and is lacking feet and ankles. Firstly, the mechanism was designed and built as a physical simulation programmed from scratch, providing a platform for hand-tuned tests and the creation of a CPG controller by genetic algorithms (GA). The oscillatory characteristics of the CPG network together with its internal connection structure and the feedback pathways from the environment were subject to GA optimization. The approach proved successful and the results were then transferred to a hardware realization of the five-link walking mechanism, to test how well these perform under real-world dynamics. Results suggest that the biological...

  2. A Combination of Central Pattern Generator-based and Reflex-based Neural Networks for Dynamic, Adaptive, Robust Bipedal Locomotion

    DEFF Research Database (Denmark)

    Di Canio, Giuliano; Larsen, Jørgen Christian; Wörgötter, Florentin

    2016-01-01

    Robotic systems inspired from humans have always been lightening up the curiosity of engineers and scientists. Of many challenges, human locomotion is a very difficult one where a number of different systems needs to interact in order to generate a correct and balanced pattern. To simulate the in...

  3. Pattern Based Graph Generator

    CERN Document Server

    Shuai, Hong-Han; Yu, Philip S; Shen, Chih-Ya; Chen, Ming-Syan

    2013-01-01

    The importance of graph mining has been widely recognized thanks to a large variety of applications in many areas, while real datasets always play important roles to examine the solution quality and efficiency of a graph mining algorithm. Nevertheless, the size of a real dataset is usually fixed and constrained according to the available resources, such as the efforts to crawl an on-line social network. In this case, employing a synthetic graph generator is a possible way to generate a massive graph (e.g., billions nodes) for evaluating the scalability of an algorithm, and current popular statistical graph generators are properly designed to maintain statistical metrics such as total node degree, degree distribution, diameter, and clustering coefficient of the original social graphs. Nevertheless, in addition to the above metrics, recent studies on graph mining point out that graph frequent patterns are also important to provide useful implications for the corresponding social networking applications, but thi...

  4. 基于中枢模式发生器的机器人行走控制%Locomotion Control of Quadruped Robot Based on Central Pattern Generators

    Institute of Scientific and Technical Information of China (English)

    陈启军; 王国星; 刘成菊

    2010-01-01

    基于中枢模式发生器(central pattern generator,CPG)的动物运动控制机理实现四足机器人AIBO的行走控制.利用Kimura振荡神经元构建CPG分布式控制网络,通过多目标遗传算法优化调整CPG网络中的参数,在AIBO上实现类似动物行走(walk)的行走模式.通过Webots仿真和实体实验,验证所设计的CPG控制网络和控制方法的可行性与有效性.

  5. Feedback From Peripheral Musculature to Central Pattern Generator in the Neurogenic Heart of the Crab Callinectes sapidus: Role of Mechanosensitive Dendrites

    Science.gov (United States)

    García-Crescioni, Keyla; Fort, Timothy J.; Stern, Estee; Brezina, Vladimir

    2010-01-01

    The neurogenic heart of decapod crustaceans is a very simple, self-contained, model central pattern generator (CPG)-effector system. The CPG, the nine-neuron cardiac ganglion (CG), is embedded in the myocardium itself; it generates bursts of spikes that are transmitted by the CG's five motor neurons to the periphery of the system, the myocardium, to produce its contractions. Considerable evidence suggests that a CPG-peripheral loop is completed by a return feedback pathway through which the contractions modify, in turn, the CG motor pattern. One likely pathway is provided by dendrites, presumably mechanosensitive, that the CG neurons project into the adjacent myocardial muscle. Here we have tested the role of this pathway in the heart of the blue crab, Callinectes sapidus. We performed “de-efferentation” experiments in which we cut the motor neuron axons to the myocardium and “de-afferentation” experiments in which we cut or ligated the dendrites. In the isolated CG, these manipulations had no effect on the CG motor pattern. When the CG remained embedded in the myocardium, however, these manipulations, interrupting either the efferent or afferent limb of the CPG-peripheral loop, decreased contraction amplitude, increased the frequency of the CG motor neuron spike bursts, and decreased the number of spikes per burst and burst duration. Finally, passive stretches of the myocardium likewise modulated the spike bursts, an effect that disappeared when the dendrites were cut. We conclude that feedback through the dendrites indeed operates in this system and suggest that it completes a loop through which the system self-regulates its activity. PMID:19828726

  6. 基于中枢神经模式的四足机器人步态控制%Quadruped Robot Gait Control Based on Central Pattern Generator

    Institute of Scientific and Technical Information of China (English)

    黄博; 姚玉峰; 孙立宁

    2010-01-01

    为实现四足机器人稳定的节律性行走,研究基于中枢神经模式发生器(Central pattern generator, CPG)的比例步态控制方式.构建互抑神经元组成的振荡器模型,并基于振荡器模型组建四足机器人髋关节CPG网络.通过仿真研究得到模型各参数与CPG网络输出特性之间的关系,确定一套整定后CPG网络的模型参数,提出四足机器人比例步态,通过CPG模型阈值的调整可实现不同占空比的步态.对基于CPG网络的步态反射特性进行分析.试验表明,该方法可实现稳定的四足机器人行走,且具备一定的障碍物反射能力,具有较好的环境适应性.

  7. 基于生物中枢模式发生器原理的四足机器人%Quadruped robot based on biological central pattern generator

    Institute of Scientific and Technical Information of China (English)

    郑浩峻; 张秀丽; 关旭; 汪劲松

    2004-01-01

    传统由人工规划产生的步态是比较僵硬的、缓慢的,缺乏灵活的自组织能力,与真正的动物步态存在很大差别.该文提出了机器人生物步态的概念.以生物的中枢模式发生器(central pattern generator, CPG)模型为核心建立四足机器人运动控制系统,建立CPG网络的权重矩阵与步态的对应关系.采用不同的权重矩阵得到四足机器人的典型步态.根据哺乳动物的肢体运动关系,建立机器人膝髋关节运动关系方程.通过仿真验证了基于生物CPG控制机理的机器人节律运动控制方法是有效的,机器人生物步态的实现是可能的.

  8. 基于中枢模式发生器的仿人机器人步态规划%Humanoid robot gait planning based on Central Pattern Generator

    Institute of Scientific and Technical Information of China (English)

    李正文; 张国良; 张维平; 羊帆

    2011-01-01

    对Matsuoka振荡器进行了分析,根据仿人机器人步态规划的要求,选用Matsuoka振荡器构建了中枢模式发生器(CPG)网络;采用遗传算法(GA)来调整网络的参数,解决了关键的网络参数调整的问题;根据CPG网络的输出结果,控制仿人机器人的相应关节,实现了仿人机器人基本步态规划。通过ADAMS进行了仿真,结果表明,该控制策略具有较理想的效果,并且原理简单,易于实现。%The Matsuoka oscillator was analyzed, according to the humanoid robot gait planning requirements, the Matsuoka oscillator was selected to construct the Central Pattern Generator (CPG) network, using genetic algorithms (GA) to adjust the network parameters, the key network parameter adjustment problem was solved; according to the CPG network output results, the humanoid robot relevant joint was controlled, the basic gait planning of the humanoid robot was achieved. Through the ADAMS simulation, the results show that this control strategy has an ideal effect, and the principle is simple, easy to implement.

  9. Generation Y Online Buying Patterns

    OpenAIRE

    Katija Vojvodić; Matea Matić

    2015-01-01

    The advantages of electronic retailing can, among other things, result in uncontrolled buying by online consumers, i.e. in extreme buying behavior. The main purpose of this paper is to analyze and determine the buying patterns of Generation Y online consumers in order to explore the existence of different types of behavior based on the characteristics of online buying. The paper also aims at exploring the relationship between extracted factors and Generation Y consumers’ buying intentions. Em...

  10. Generation Y Online Buying Patterns

    Directory of Open Access Journals (Sweden)

    Katija Vojvodić

    2015-12-01

    Full Text Available The advantages of electronic retailing can, among other things, result in uncontrolled buying by online consumers, i.e. in extreme buying behavior. The main purpose of this paper is to analyze and determine the buying patterns of Generation Y online consumers in order to explore the existence of different types of behavior based on the characteristics of online buying. The paper also aims at exploring the relationship between extracted factors and Generation Y consumers’ buying intentions. Empirical research was conducted on a sample of 515 consumers in the Dubrovnik-Neretva County. Based on the factor analysis, research results indicate that Generation Y online consumers are influenced by three factors: compulsivity, impulsivity, and functionality. The analysis of variance reveals that significant differences exist between the extracted factors and Generation Y’s online buying characteristics. In addition, correlation analysis shows a statistically significant correlation between the extracted factors and Generation Y’s buying intentions.

  11. A Central Limit Theorem for Repeating Patterns

    CERN Document Server

    Abrams, Aaron; Landau, Henry; Landau, Zeph; Pommersheim, James

    2012-01-01

    This note gives a central limit theorem for the length of the longest subsequence of a random permutation which follows some repeating pattern. This includes the case of any fixed pattern of ups and downs which has at least one of each, such as the alternating case considered by Stanley in [2] and Widom in [3]. In every case considered the convergence in the limit of long permutations is to normal with mean and variance linear in the length of the permutations.

  12. Betweenness centrality patterns in random planar graphs

    CERN Document Server

    Lion, Benjamin

    2016-01-01

    Random planar graphs appear in a variety of context and it is important for many different applications to be able to characterize their structure. Local quantities fail to give interesting information and it seems that path-related measures are able to convey relevant information about the organization of these structures. In particular, nodes with a large betweenness centrality (BC) display non-trivial patterns, such as loops of very central nodes. We discuss briefly empirical results for different random planar graphs and we propose a toy model which allows us to discuss the condition for the emergence of non-trivial patterns such as central loops. This toy model is made of a star network with $N_b$ branches of size $n$ and links of weight $1$, superimposed to a loop at distance $\\ell$ from the center and with links of weight $w$. We estimate for this model the BC at the center and on the loop and we show that the loop can be more central than the origin if $w

  13. Dopamine modulates two potassium currents and inhibits the intrinsic firing properties of an identified motor neuron in a central pattern generator network.

    Science.gov (United States)

    Kloppenburg, P; Levini, R M; Harris-Warrick, R M

    1999-01-01

    The two pyloric dilator (PD) neurons are components [along with the anterior burster (AB) neuron] of the pacemaker group of the pyloric network in the stomatogastric ganglion of the spiny lobster Panulirus interruptus. Dopamine (DA) modifies the motor pattern generated by the pyloric network, in part by exciting or inhibiting different neurons. DA inhibits the PD neuron by hyperpolarizing it and reducing its rate of firing action potentials, which leads to a phase delay of PD relative to the electrically coupled AB and a reduction in the pyloric cycle frequency. In synaptically isolated PD neurons, DA slows the rate of recovery to spike after hyperpolarization. The latency from a hyperpolarizing prestep to the first action potential is increased, and the action potential frequency as well as the total number of action potentials are decreased. When a brief (1 s) puff of DA is applied to a synaptically isolated, voltage-clamped PD neuron, a small voltage-dependent outward current is evoked, accompanied by an increase in membrane conductance. These responses are occluded by the combined presence of the potassium channel blockers 4-aminopyridine and tetraethylammonium. In voltage-clamped PD neurons, DA enhances the maximal conductance of a voltage-sensitive transient potassium current (IA) and shifts its Vact to more negative potentials without affecting its Vinact. This enlarges the "window current" between the voltage activation and inactivation curves, increasing the tonically active IA near the resting potential and causing the cell to hyperpolarize. Thus DA's effect is to enhance both the transient and resting K+ currents by modulating the same channels. In addition, DA enhances the amplitude of a calcium-dependent potassium current (IO(Ca)), but has no effect on a sustained potassium current (IK(V)). These results suggest that DA hyperpolarizes and phase delays the activity of the PD neurons at least in part by modulating their intrinsic postinhibitory recovery

  14. Generation of central exclusive final states

    CERN Document Server

    Lönnblad, Leif

    2016-01-01

    We present a scheme for the generation of central exclusive final states in the Pythia 8 program. The implementation allows for the investigation of higher order corrections to such exclusive processes as approximated by the initial-state parton shower in Pythia 8. To achieve this, the spin and colour decomposition of the initial-state shower has been worked out, in order to determine the probability that a partonic state generated from an inclusive sub-process followed by a series of initial-state parton splittings can be considered as an approximation of an exclusive colour- and spin-singlet process. We use our implementation to investigate effects of parton showers on some examples of central exclusive processes, and find sizeable effects on di-jet production, while the effects on e.g. central exclusive Higgs production are minor.

  15. Bipedal Locomotion: A Fractional CPG for Generating Patterns

    OpenAIRE

    Pinto, Carla M. A.; Machado, J.A. Tenreiro

    2009-01-01

    Proceedings of the 10th Conference on Dynamical Systems Theory and Applications There has been an increase interest in the study of animal locomotion. Many models for the generation of locomotion patterns of different animals, such as centipedes, millipedes, quadrupeds, hexapods, bipeds, have been proposed. The main goal is the understanding of the neural bases that are behind animal locomotion. In vertebrates, goal-directed locomotion is a complex task, involving the central pattern ge...

  16. Airflow Pattern Generated by Three Air Diffusers

    DEFF Research Database (Denmark)

    Olmedo, Inés; Nielsen, Peter V.; Ruiz de Adana, Manuel

    2011-01-01

    The correct description of air diffusers plays a crucial role in the CFD predictions of the airflow pattern into a room. The numerical simulation of air distribution in an indoor space is challenging because of the complicated airflow pattern generated. Many authors have developed simplified geom...

  17. Generating a Pattern Matching Compiler by Partial Evaluation

    DEFF Research Database (Denmark)

    Jørgensen, Knud Jesper

    1991-01-01

    Datalogi, partial Evaluation, Compiling, denotational Semantics, Pattern Matching, Semantic directed Compiler Generation......Datalogi, partial Evaluation, Compiling, denotational Semantics, Pattern Matching, Semantic directed Compiler Generation...

  18. Legume Diversity Patterns in West Central Africa

    NARCIS (Netherlands)

    Estrella, de la M.; Mateo, M.A.; Wieringa, J.J.; Mackinder, B.; Munoz, J.

    2012-01-01

    Objectives - Species Distribution Models (SDMs) are used to produce predictions of potential Leguminosae diversity in West Central Africa. Those predictions are evaluated subsequently using expert opinion. The established methodology of combining all SDMs is refined to assess species diversity withi

  19. The effect of gait Central pattern generators on walking function of stroke patients%步态中枢模式发生器对脑卒中偏瘫患者步行能力的影响

    Institute of Scientific and Technical Information of China (English)

    王文威; 潘翠环; 陈艳; 罗兆良; 罗丽娟

    2011-01-01

    Objective:To explore the effect of gait central pattern generators on walking function of stroke patients.Method: Eighty stroke patients were randomly assigned to the treatment group (observation group, 40 cases) and the control group (40 cases).AII the patients were treated with rehabilitation training. In addition, observation group adopted the activation of gait central pattern generators(CPG) training. The total course of 2 groups were 1month.Patients were assessed with lower extremity Fugl-Meyer motor function scale(FMA), modified Ashworth scale (MAS), Holden walking function rating scale (FAC) before and after rehabilitation treatment.At the same time, footprint analysis was used to measure and record the time and distance parameters of walking. The improvement of gait was analysed.Result: Compared to before, after the activation of gait CPG training, there were significant differences of FMA,FAC scores(P<0.05), there were different degrees of improvement in time and distance parameters of walking(P<0.05).Conclusion:The activation of gait CPG training can raise the lower extremity motor function as well as the practical walking ability, and improve the walking gait of stroke patients.%目的:探讨步态中枢模式发生器对脑卒中偏瘫患者步行能力的影响.方法:将80例脑卒中偏瘫患者随机分为治疗组(观察组)40例和对照组40例,两组患者均采用常规康复方法进行治疗,观察组还另外采用激活步态中枢模式发生器(CPG)的运动训练方法.两组患者总疗程均为1个月.分别在康复治疗前后采用Fugl-Meyer下肢运动功能量表(FMA)、改良Ashworth量表(MAS)、Holden步行功能分级量表(FAC)进行评定,同时选用足印分析法测量并记录步行时的时间距离参数的变化,分析步态的改善情况.结果:患者经过激活步态CPG的运动训练方法训练后,其FMA、FAC评分与治疗前相比差异有显著性意义(P<0.05),步行时间距离各参数也

  20. 基于CPG的双足机器人多层步行控制器设计%Central pattern generator based multi-level walking controller design of biped robot

    Institute of Scientific and Technical Information of China (English)

    薛方正; 陈强; 厚之成

    2015-01-01

    For walking controller design of the biped robot, a walking controller with multi-level structure is proposed by integrating the central pattern generator(CPG) stability analysis from the perspective of biological inspiration. The walking model of the biped robot is given. Then, the multi-level structure walking controller is proposed. By using the limit cycle theory, the walking stability is analyzed systematically. Compared with existing methods, the propoed controller is superior in simple structure, good versatility and converient online smoothing correction on the premise of walking stability. The simulation results show the effectiveness of proposed method.%针对双足机器人步行控制器的设计问题,基于生物学启发原理,提出一种基于中枢模式发生器(CPG)与稳定性分析相结合的多层次结构控制器设计方法。分析机器人的步行运动,给出双足运动描述。基于CPG理论设计多层次结构的步行控制器,应用极限环理论方法分析运动稳定性。在保证步行稳定的前提下,所提出的控制方法具有结构简单、通用性好、方便在线平滑修正等优点,步行仿真实验验证了所提出算法的有效性。

  1. Synaptic vesicle generation from central nerve terminal endosomes.

    Science.gov (United States)

    Kokotos, Alexandros C; Cousin, Michael A

    2015-03-01

    Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain the fidelity of neurotransmission across a wide range of stimulation intensities. For this to be achieved, nerve terminals integrate a number of complementary endocytosis modes whose activation spans the breadth of these neuronal stimulation patterns. Two such modes are ultrafast endocytosis and activity-dependent bulk endocytosis, which are triggered by stimuli at either end of the physiological range. Both endocytosis modes generate endosomes directly from the nerve terminal plasma membrane, before the subsequent production of SVs from these structures. This review will discuss the current knowledge relating to the molecular mechanisms involved in the generation of SVs from nerve terminal endosomes, how this relates to other mechanisms of SV production and the functional role of such SVs.

  2. 基于中枢模式产生器的主动式智能踝关节控制的研究%Study on the Control of Dynamic Artificial Limb Ankle Based on Central Pattern Generator

    Institute of Scientific and Technical Information of China (English)

    郭欣; 徐彩玉; 李明月; 苏龙涛

    2014-01-01

    In order to obtain the normal gait for the prosthesis-carrier with the change of external environment and gait,we designed a model of dynamic ankle prosthesis and control system and introduced the strategy of central pattern generator (CPG) about the moving trail of dynamic ankle prosthesis.The dynamic parts,which are incorporated in the model of dynamic ankle prosthesis,provide power in order to have anthropic function and character.The tool of Matlab/simulink was used to simulate the strategy.The simulation results showed that the strategy of CPG learning control in this study was effective and could track the reference trail rapidly and fit the moving trail of a person's normal limb.It can make the prosthetic timely regulation and action,enhance the prosthetic intelligence.It has important practical value for intelligent prosthesis development based on this analysis of technology.%为了使主动式踝关节假肢携带者能更好地根据外部环境和步态的变化实现假肢自然行走,设计了主动式智能踝关节假肢的机械结构和控制系统,提出了主动式踝关节假肢运动轨迹的中枢模式产生器(CPG)控制策略.主动式踝关节假肢通过动力机构为人体提供了运动动力,可实现人体运动的主要功能和特性.通过Matlab/simulink仿真,有效验证了基于生物中枢模式产生器控制机制的主动式踝关节的运动控制方法,能够使主动式踝关节假肢的输出轨迹准确快速地跟踪期望轨迹.因此该主动式踝关节假肢能实现及时调节和动作,智能性增强,同时本文提出的该项技术对智能假肢的发展具有重要的实用价值.

  3. Enhancing SAT-Based Test Pattern Generation

    Institute of Scientific and Technical Information of China (English)

    LIU Xin; XIONG You-lun

    2005-01-01

    This paper presents modeling tools based on Boolean satisfiability (SAT) to solve problems of test generation for combinational circuits. It exploits an added layer to maintain circuit-related information and value justification relations to a generic SAT algorithm. It dovetails binary decision graphs (BDD) and SAT techniques to improve the efficiency of automatic test pattern generation (ATPG). More specifically, it first exploits inexpensive reconvergent fanout analysis of circuit to gather information on the local signal correlation by using BDD learning, then uses the above learned information to restrict and focus the overall search space of SAT-based ATPG. Its learning technique is effective and lightweight. The experimental results demonstrate the effectiveness of the approach.

  4. Patterning techniques for next generation IC's

    Science.gov (United States)

    Balasinski, A.

    2007-12-01

    Reduction of linear critical dimensions (CDs) beyond 45 nm would require significant increase of the complexity of pattern definition process. In this work, we discuss the key successor methodology to the current optical lithography, the Double Patterning Technique (DPT). We compare the complexity of CAD solutions, fab equipment, and wafer processing with its competitors, such as the nanoimprint (NIL) and the extreme UV (EUV) techniques. We also look ahead to the market availability for the product families enabled using the novel patterning solutions. DPT is often recognized as the most viable next generation lithography as it utilizes the existing equipment and processes and is considered a stop-gap solution before the advanced NIL or EUV equipment is developed. Using design for manufacturability (DfM) rules, DPT can drive the k1 factor down to 0.13. However, it faces a variety of challenges, from new mask overlay strategies, to layout pattern split, novel OPC, increased CD tolerances, new etch techniques, as well as long processing time, all of which compromise its return on investment (RoI). In contrast, it can be claimed e.g., that the RoI is the highest for the NIL but this technology bears significant risk. For all novel patterning techniques, the key questions remain: when and how should they be introduced, what is their long-term potential, when should they be replaced, and by what successor technology. We summarize the unpublished results of several panel discussions on DPT at the recent SPIE/BACUS conferences.

  5. Centrally patterned rhythmic activity integrated by a peripheral circuit linking multiple oscillators.

    Science.gov (United States)

    Jellies, John; Kueh, Daniel

    2012-08-01

    The central pattern generator for heartbeat in the medicinal leech, Hirudo generates rhythmic activity conveyed by heart excitor motor neurons in segments 3-18 to coordinate the bilateral tubular hearts and side vessels. We focus on behavior and the influence of previously un-described peripheral nerve circuitry. Extracellular recordings from the valve junction (VJ) where afferent vessels join the heart tube were combined with optical recording of contractions. Action potential bursts at VJs occurred in advance of heart tube and afferent vessel contractions. Transections of nerves were performed to reduce the output of the central pattern generator reaching the heart tube. Muscle contractions persisted but with a less regular rhythm despite normal central pattern generator rhythmicity. With no connections between the central pattern generator and heart tube, a much slower rhythm became manifest. Heart excitor neuron recordings showed that peripheral activity might contribute to the disruption of centrally entrained contractions. In the model presented, peripheral activity would normally modify the activity actually reaching the muscle. We also propose that the fundamental efferent unit is not a single heart excitor neuron, but rather is a functionally defined unit of about three adjacent motor neurons and the peripheral assembly of coupled peripheral oscillators.

  6. Generating IDS Attack Pattern Automatically Based on Attack Tree

    Institute of Scientific and Technical Information of China (English)

    向尕; 曹元大

    2003-01-01

    Generating attack pattern automatically based on attack tree is studied. The extending definition of attack tree is proposed. And the algorithm of generating attack tree is presented. The method of generating attack pattern automatically based on attack tree is shown, which is tested by concrete attack instances. The results show that the algorithm is effective and efficient. In doing so, the efficiency of generating attack pattern is improved and the attack trees can be reused.

  7. 基于中枢神经模式产生器机器人的控制网络%Control Network for Humanoid Robots Based on Central Pattern Generator

    Institute of Scientific and Technical Information of China (English)

    于小翔

    2011-01-01

    分析了基于中枢神经模式产生器(Ccntral Pattern Generator,CPG)的仿人机器人控制网络系统结构的特点,介绍了振荡器的数学模型.研究了CPG网络中各神经元的刺激方式,采用Hopf非线性振荡器构造神经元,模仿人类的行走步态,设计一种6关节控制网络.计算仿真中该网络输出信号稳定,运动节奏符合设计要求.最后,应用一仿人机器人完成了实验,提高了其行走的速度和稳定性,验证了该网络的有效性.

  8. Generation 1.5 Written Error Patterns: A Comparative Study

    Science.gov (United States)

    Doolan, Stephen M.; Miller, Donald

    2012-01-01

    In an attempt to contribute to existing research on Generation 1.5 students, the current study uses quantitative and qualitative methods to compare error patterns in a corpus of Generation 1.5, L1, and L2 community college student writing. This error analysis provides one important way to determine if error patterns in Generation 1.5 student…

  9. Pattern Generation by Bubble Packing Method

    Directory of Open Access Journals (Sweden)

    Goel V.K.

    2013-06-01

    Full Text Available This paper presents a new computational method forornamental Pattern design. The work is a concerted effort ofevaluation of various methods and the comparatively betterprocess is used for designing keeping in mind the accuracyrequirement for such Indian traditional ethnic designs. The firststep in the process to apply the CAD tools to design the patterns.Small semantics (profile are made using the mathematicalmodelling to make different pattern. Geometric constraints suchas scaling, rotation, transformation etc. are applied to make andmodify the profiles. To create patterns, obtains node locationsthrough a physically based particle simulation, which we call'bubble packing. Bubbles are closely packed on the corners,edges and on the surface domain, and nodes are placed at thecenters of the bubbles. Experimental results show that ourmethod can create high quality ornamental patterns. Thefabrication of the ornaments is on rapid prototype machine.

  10. Reconstructing spatial and temporal patterns of paleoglaciation across Central Asia

    Science.gov (United States)

    Stroeven, Arjen P.

    2014-05-01

    Understanding the behaviour of mountain glaciers and ice caps, the evolution of mountain landscapes, and testing global climate models all require well-constrained information on past spatial and temporal patterns of glacier change. Particularly important are transitional regions that have high spatial and temporal variation in glacier activity and that can provide a sensitive record of past climate change. Central Asia is an extreme continental location with glaciers that have responded sensitively to variations in major regional climate systems. As an international team, we are reconstructing glacial histories of several areas of the Tibetan Plateau as well as along the Tian Shan, Altai and Kunlun Mountains. Building on previous work, we are using remote sensing-based geomorphological mapping augmented with field observations to map out glacial landforms and the maximum distributions of erratics. We then use cosmogenic nuclide Be-10 and Al-26, optically stimulated luminescence, and electron spin resonance dating of moraines and other landforms to compare dating techniques and to constrain the ages of defined extents of paleo-glaciers and ice caps. Comparing consistently dated glacial histories across central Asia provides an opportunity to examine shifts in the dominance patterns of climate systems over time in the region. Results to date show significant variations in the timing and extent of glaciation, including areas in the southeast Tibetan Plateau and Tian Shan with extensive valley and small polythermal ice cap glaciation during the global last glacial maximum in contrast to areas in central and northeast Tibetan Plateau that had very limited valley glacier expansion then. Initial numerical modelling attempting to simulate mapped and dated paleoglacial extents indicates that relatively limited cooling is sufficient to produce observed past expansions of glaciers across the Tibetan Plateau, and predicts complex basal thermal regimes in some locations that

  11. Generation and Analysis of Constrained Random Sampling Patterns

    DEFF Research Database (Denmark)

    Pierzchlewski, Jacek; Arildsen, Thomas

    2016-01-01

    indicates signal sampling points in time. Practical random sampling patterns are constrained by ADC characteristics and application requirements. In this paper, we introduce statistical methods which evaluate random sampling pattern generators with emphasis on practical applications. Furthermore, we propose...... a new random pattern generator which copes with strict practical limitations imposed on patterns, with possibly minimal loss in randomness of sampling. The proposed generator is compared with existing sampling pattern generators using the introduced statistical methods. It is shown that the proposed......Random sampling is a technique for signal acquisition which is gaining popularity in practical signal processing systems. Nowadays, event-driven analog-to-digital converters make random sampling feasible in practical applications. A process of random sampling is defined by a sampling pattern, which...

  12. Rewrite Systems, Pattern Matching, and Code Generation

    Science.gov (United States)

    1988-06-09

    iii 2 5 7 17 23 28 29 29 30 34 47 49 50 51 52 55 56 58 61 63 66 70 71 71 73 73...Transformations Quicn a bucn arbol se anima, buena sombra le cobija1 [Old Spanish Saying] 1 Trees arc hierarchical mathematical objects. Their...there are three nullary operators a, b, and c. The B-fsa is the same as in Figure 2.2. 50 Pattern Set: + + /\\ A * z X * 1\\ 1\\ XY YZ Sub

  13. Texture Pattern Generation Using Clonal Mosaic

    Institute of Scientific and Technical Information of China (English)

    How Jiann Teo; Kok Cheong Wong

    2006-01-01

    In this paper, an effective system for synthesizing animal skin patterns on arbitrary polygonal surfaces is developed. To accomplish the task, a system inspired by the Clonal Mosaic (CM) model is proposed. The CM model simulates cells' reactions on arbitrary surface. By controlling the division, mutation and repulsion of cells, a regulated spatial arrangement of cells is formed. This arrangement of cells shows appealing result, which is comparable with those natural patterns observed from animal skin. However, a typical CM simulation process incurs high computational cost, where the distances among cells across a polygonal surface are measured and the movements of cells are constrained on the surface. In this framework, an approach is proposed to transform each of the original 3D geometrical planes of the surface into its Canonical Reference Plane Structure. This structure helps to simplify a 3D computational problem into a more manageable 2D problem. Furthermore, the concept of Local Relaxation is developed to optimally enhance the relaxation process for a typical CM simulation. The performances of the proposed solution methods have been verified with extensive experimental results.

  14. Optogenetic control of spinal microcircuits : insights into locomotor rhythm and pattern generation

    OpenAIRE

    Hägglund, Martin

    2013-01-01

    Mammalian locomotion is a complex task in which hundreds of muscles work together in a coordinated fashion. Neural networks in the spinal cord, known as central pattern generators (CPGs), carry all the components necessary to produce the cyclical pattern of muscle activity needed for locomotion. The fact that the locomotor CPG is innate and highly localized makes it outstanding as a subject to study how a complex, but concrete behavior, is produced by a neuronal network. Two fundamental as...

  15. Identification of Bacteria by Patterns Generated from Odor Spectra

    CERN Document Server

    Chang, Hung-Chih; King, Maria D; Kwan, Chiman

    2009-01-01

    We use the power density spectra obtained by fluctuation-enhanced sensing of bacterial odors (Escherichia coli and Anthrax-surrogate Bacillus subtilis) to generate new, highly distinguishable, types of patterns based on the average slope of the spectra in different frequency ranges. Such plots can be considered as "fingerprints" of bacterial odors. Three different ways of pattern generation are tested, including a simple binary version. The obtained patterns are simple enough to identify the situation by the naked eye without a pattern recognizer.

  16. Reproduction Patterns of Scleractinian Corals in the Central Red Sea

    KAUST Repository

    Bouwmeester, Jessica

    2013-12-01

    Early work on the reproductive seasonality of corals in the Red Sea suggested that corals exhibit temporal reproductive isolation, unlike on the Great Barrier Reef where many species spawn in synchrony. More recent work has however shown high synchrony in the maturity of gametes in Acropora species, suggesting multi-specific spawning is likely to occur in the Red Sea. In this thesis I investigate the patterns of coral reproduction in the central Red Sea. The spawning season in the central Red Sea lasts four months, from April to July and spawning occurs on nights around the full moon. During this period Acropora species show a peak of spawning in April, with some species spawning again in May. The level of synchrony, quantified with a spawning synchrony index, is comparable to other locations where multi-specific spawning has been reported. Observations over two consecutive years show that the synchrony of spawning was lower in spring 2012 than in spring 2011, and thus that spawning patterns are variable from one year to the other. Coral settlement patterns on artificial substrata confirmed a main spawning season in the spring but also supported reproductive data suggesting that some Porites spawn in October-November. Settlement was studied over 2.5 years on a reef, which had suffered recently from high mortality after a local bleaching event. Settlement appeared low but post-bleaching studies from other locations indicated similar abundances and showed that recruits generally did not increase until 5 years after the bleaching event. Abundance of juvenile corals however started to increase significantly three years after the bleaching. Successful recruitment, although low suggests that the coral assemblage on the affected reef will most likely recover as long as it is not affected by another disturbance.

  17. Characteristic flow patterns generated by macrozoobenthic structures

    Science.gov (United States)

    Friedrichs, M.; Graf, G.

    2009-02-01

    A laboratory flume channel, equipped with an acoustic Doppler flow sensor and a bottom scanning laser, was used for detailed, non-intrusive flow measurements (at 2 cm s - 1 and 10 cm s - 1 ) around solitary biogenic structures, combined with high-resolution mapping of the structure shape and position. The structures were replicates of typical macrozoobenthic species commonly found in the Mecklenburg Bight and with a presumed influence on both, the near-bed current regime and sediment transport dynamics: a worm tube, a snail shell, a mussel, a sand mound, a pit, and a cross-stream track furrow. The flow was considerably altered locally by the different protruding structures (worm tube, snail, mussel and mound). They reduced the horizontal approach velocity by 72% to 79% in the wake zone at about 1-2 cm height, and the flow was deflected around the structures with vertical and lateral velocities of up to 10% and 20% of the free-stream velocity respectively in a region adjacent to the structures. The resulting flow separation (at flow Reynolds number of about 4000 and 20,000 respectively) divided an outer deflection region from an inner region with characteristic vortices and the wake region. All protruding structures showed this general pattern, but also produced individual characteristics. Conversely, the depressions (track and pit) only had a weak influence on the local boundary layer flow, combined with a considerable flow reduction within their cavities (between 29% and 53% of the free-stream velocity). A longitudinal vortex formed, below which a stagnant space was found. The average height affected by the structure-related mass flow rate deficit for the two velocities was 1.6 cm and 1.3 cm respectively (80% of height and 64%) for the protruding structures and 0.6 cm and 0.9 cm (90% and 127% of depth) for the depressions. Marine benthic soft-bottom macrozoobenthos species are expected to benefit from the flow modifications they induce, particularly in terms of

  18. MRI in central nervous system infections: A simplified patterned approach

    Institute of Scientific and Technical Information of China (English)

    Krithika; Rangarajan; Chandan; J; Das; Atin; Kumar; Arun; Kumar; Gupta

    2014-01-01

    Recognition and characterization of central nervous system infections poses a formidable challenge to the neuro-radiologist.Imaging plays a vital role,the lesions typically being relatively inaccessible to tisue sampling.The results of an accurate diagnosis are endlessly re-warding,given the availability of excellent pharmaco-logical regimen.The availability of numerous magnetic resonance(MR)sequences which provide functional and molecular information is a powerful tool in the hands of the radiologist.However,the plethora of se-quences and the possibilities on each sequence is also intimidating,and often confusing as well as time con-suming.While a large number of reviews have already described in detail the possible imaging findings in each infection,we intend to classify infections based on their imaging characteristics.In this review we describe an algorithm for first classifying the imaging findings into patterns based on basic MR sequences(T1,T2 and enhancement pattern with Gadolinium),and then sub-classify them based on more advanced molecular and functional sequences(Diffusion,Perfusion,Susceptibili-ty imaging,MR Spectroscopy).This patterned approachis intended as a guide to radiologists in-training and in-practice for quickly narrowing their list of differentials when faced with a clinical challenge.The entire content of the article has also been summarised in the form of flow-charts for the purpose of quick reference.

  19. An algorithm for generating quasiperiodic patterns and their approximants

    Indian Academy of Sciences (India)

    E A Lord; K Ramakrishnan; S Ranganathan

    2000-04-01

    An algorithm for projecting the interior of a hypercube in -dimensions on to an -dimensional subspace has been developed and incorporated into a computer program for generating quasiperiodic and periodic patterns in an -dimensional subspace. Some aspects of the resulting orthorhombic approximants to Penrose tiling patterns are discussed and illustrated.

  20. Single-unit pattern generators for quadruped locomotion

    DEFF Research Database (Denmark)

    Morse, Gregory; Risi, Sebastian; Snyder, Charles R;

    2013-01-01

    locomotion can generate oscillations through popular techniques such as continuous time recurrent neural networks (CTRNNs) or sinusoidal input, they typically face a challenge in maintaining long-term stability. The aim of this paper is to address this challenge by introducing an effective alternative based...... on a new type of neuron called a single-unit pattern generator (SUPG). The SUPG, which is indirectly encoded by a compositional pattern producing network (CPPN) evolved by HyperNEAT, produces a flexible temporal activation pattern that can be reset and repeated at any time through an explicit trigger input...

  1. The Inspiration for the Motion Control of Robot from Central Pattern Generator of Animal's Locomotion Instruction%动物运动指令的中枢模式发生器对机器人运动控制的启示

    Institute of Scientific and Technical Information of China (English)

    李宏凯; 孙久荣; 戴振东

    2008-01-01

    动物运动指令的中枢模式发生器(central pattern generator, CPG)在动物的节律运动中发挥着重要的作用,对机器人的仿生控制方法研究具有借鉴意义.首先介绍了CPG的神经环路和控制机制,然后分析了组成CPG的非线性振荡器的典型数学模型,接着介绍了利用CPG进行机器人运动控制在国内外的发展现状,最后展望了其应用前景.

  2. Hair patterns of the lower limb in Central Indian males.

    Science.gov (United States)

    Chaurasia, B D

    1977-08-01

    The distribution of hair of the right lower limb has been studied in a random sample of 220 healthy Central Indian males 17 to 45 years of age. The common hair patterns observed are the proximal phalangeal hair in all toes in 55.45%, the middle phalangeal hair in the third toe in 8.18%, the tibial on the dorsum of foot in 69.55%, and the pedo-cruro-femoral in the lower limb in 70.00% subjects. Comparison of these findings with those of the right upper limb shows that hairiness of the two limbs is correlated, that the dorsum of foot is less hairy than the dorsum of hand, and that the third and second toes are comparable with the fourth and third fingers, respectively, as regards their middle phalangeal hair. Comparison with the available literature shows that the Central Indian males resemble the Whites in having greater frequency of middle phalangeal hair than those of the Negroes, that the dorsum of feet of this population is less hairy than the White and more hairy than the Negroes, and that the general hairiness of the lower limb is more or less equal in the three groups of persons.

  3. Dynamic array generation and pattern formation for optical tweezers

    DEFF Research Database (Denmark)

    Mogensen, P.C.; Glückstad, J.

    2000-01-01

    The generalised phase contrast approach is used for the generation of optical arrays of arbitrary beam shape, suitable for applications in optical tweezers for the manipulation of biological specimens. This approach offers numerous advantages over current techniques involving the use of computer......-generated holograms or diffractive optical elements. We demonstrate a low-loss system for generating intensity patterns suitable for the trapping and manipulation of small particles or specimens....

  4. High Quality Test Pattern Generation and Boolean Satisfiability

    CERN Document Server

    Eggersglüß, Stephan

    2012-01-01

    This book provides an overview of automatic test pattern generation (ATPG) and introduces novel techniques to complement classical ATPG, based on Boolean Satisfiability (SAT).  A fast and highly fault efficient SAT-based ATPG framework is presented which is also able to generate high-quality delay tests such as robust path delay tests, as well as tests with long propagation paths to detect small delay defects. The aim of the techniques and methodologies presented in this book is to improve SAT-based ATPG, in order to make it applicable in industrial practice. Readers will learn to improve the performance and robustness of the overall test generation process, so that the ATPG algorithm reliably will generate test patterns for most targeted faults in acceptable run time to meet the high fault coverage demands of industry. The techniques and improvements presented in this book provide the following advantages: Provides a comprehensive introduction to test generation and Boolean Satisfiability (SAT); Describes a...

  5. Inductive class representation and its central role in pattern recognition

    Energy Technology Data Exchange (ETDEWEB)

    Goldfarb, L. [Univ. of New Brunswick, Fredericton, New Brunswick (Canada)

    1996-12-31

    The definition of inductive learning (IL) based on the new concept of inductive class representation (ICR) is given. The ICR, in addition to the ability to recognize a noise-corrupted object from the class, must also provide the means to generate every element in the resulting approximation of the class, i.e., the emphasis is on the generative capability of the ICR. Thus, the IL problem absorbs the main difficulties associated with a satisfactory formulation of the pattern recognition problem. This formulation of the IL problem appeared gradually as a result of the development of a fundamentally new formal model of IL--evolving transformation system (ETS) model. The model with striking clarity suggests that IL is the basic process which produces all the necessary {open_quotes}structures{close_quotes} for the recognition process, which is built directly on top of it. Based on the training set, the IL process, constructs optimal discriminatory (symbolic) weighted {open_quotes}features{close_quotes} which induce the corresponding optimal (symbolic) distance measure. The distance measure is a generalization of the weighted Levenshtein, or edit, distance defined on strings over a finite alphabet. The ETS model has emerged as a result of an attempt to unify two basic, but inadequate, approaches to pattern recognition: the classical vector space based and the syntactic approaches. ETS also elucidates with remarkable clarity the nature of the interrelationships between the corresponding symbolic and numeric mechanisms, in which the symbolic mechanisms play a more fundamental part. The model, in fact, suggests the first formal definition of the symbolic mathematical structure and also suggests a fundamentally different, more satisfactory, way of introducing the concept of fuzziness. The importance of the ICR concept to semiotics and semantics should become apparent as soon as one fully realizes that it represents the class and specifies the semantics of the class.

  6. Identifying network topologies that can generate turing pattern.

    Science.gov (United States)

    Zheng, M Mocarlo; Shao, Bin; Ouyang, Qi

    2016-11-07

    Turing pattern provides a paradigm of non-equilibrium self-organization in reaction-diffusion systems. On the basis of many mathematical studies, it has been proposed that various biological development processes use Turing instability to achieve periodic patterns. In this paper, we introduce a framework to systematic identify network topologies that are capable for Turing pattern formation. All possible 2, 3-node genetic regulatory networks are enumerated and linear stability analysis is applied to access their ability to generate Turing instability. We find that all 3-node networks that can achieve Turing pattern can be mapped to either pure or cross activator-inhibitor mechanisms, and the pure activator-inhibitor system is more robust for Turing pattern formation than the other one. Additional linkages can further increase the performance of the circuit by either introducing another core topology or complementing existing regulations. Moreover, we find that addition of a fixed node enables the formation of Turing pattern even when the diffusion coefficients of two morphogens are fairly close to each other. Our results provide the design principle of robust circuits for Turing pattern generation and can be further applied for systematically exploring other bifurcation phenomena.

  7. Ring Counter Based ATPG for Low Transition Test Pattern Generation.

    Science.gov (United States)

    Begam, V M Thoulath; Baulkani, S

    2015-01-01

    In test mode test patterns are applied in random fashion to the circuit under circuit. This increases switching transition between the consecutive test patterns and thereby increases dynamic power dissipation. The proposed ring counter based ATPG reduces vertical switching transitions by inserting test vectors only between the less correlative test patterns. This paper presents the RC-ATPG with an external circuit. The external circuit consists of XOR gates, full adders, and multiplexers. First the total number of transitions between the consecutive test patterns is determined. If it is more, then the external circuit generates and inserts test vectors in between the two test patterns. Test vector insertion increases the correlation between the test patterns and reduces dynamic power dissipation. The results prove that the test patterns generated by the proposed ATPG have fewer transitions than the conventional ATPG. Experimental results based on ISCAS'85 and ISCAS'89 benchmark circuits show 38.5% reduction in the average power and 50% reduction in the peak power attained during testing with a small size decoding logic.

  8. Pattern of skin diseases among Central African refugees in Chad

    Directory of Open Access Journals (Sweden)

    Ahmed Fawzi Ismael

    2015-08-01

    Full Text Available Aim: to describe the pattern of skin diseases among refugees attending the dermatology clinic in refugee camps in southern Chad. Methods: A descriptive clinic-based cross-sectional study was done in two refugee camps of people from Republic of Central Africa in Southern Chad. Diagnosis of skin diseases was done through clinical examination by a single dermatologist along with the help of hand lens provided with illumination. Lack of investigations and other skin diagnostic tools prevented further confirmation of diagnosis. Data was manually analyzed and diagnosis was presented as number and percent using the ICD -10 of the World Health Organization. Results: A total of 366 dermatologic diseases were diagnosed in 361 patients. Certain infectious and parasitic diseases and dermatitis/ eczema were the commonest diagnostic categories (39.9% and 22.45; respectively followed by disorders of skin appendices (15% and infections of skin and subcutaneous tissues (13.1%. Tinea barbae /capitis, ringworm and impetigo are the commonest recorded infections (11.5%, 10.1% and 7.9%; respectively. Miliaria and acne vulgaris were the most frequent disorders of skin appendages. Conclusions: Infectious skin diseases are common among refugees. There are urgent needs for health education and promotion of personal hygiene with adequate sanitation as well as availability of diagnostic tests [TAF Prev Med Bull 2015; 14(4.000: 324-328

  9. Robust central pattern generators for embodied hierarchical reinforcement learning

    NARCIS (Netherlands)

    Snel, M.; Whiteson, S.; Kuniyoshi, Y.

    2011-01-01

    Hierarchical organization of behavior and learning is widespread in animals and robots, among others to facilitate dealing with multiple tasks. In hierarchical reinforcement learning, agents usually have to learn to recombine or modulate low-level behaviors when facing a new task, which costs time t

  10. Valuable Subversions: Gendered Generativity and Sorcerous Production in Central Mozambique

    Directory of Open Access Journals (Sweden)

    Bjørn Enge Bertelsen

    2016-11-01

    Full Text Available How is one to analyze the existence of a subterranean dwarfish couple (zwidoma occupying the space underneath cooking places and whose central purpose is to reinforce a market woman's sales - but simultaneously feeding off her very body? Using urban and rural ethnographic material from central Mozambique, where such assemblages comprising the zwidoma and a woman are integral to economic life and social orders, this article contextualizes such constellations - effectively interferences within various domains of value - by undertaking an analysis of gendered modalities of generativity. Further, by meditating on various understandings of cosmology and, ultimately, the dynamics constituting the realms of the real, it presents an alternative to influential analyses of capitalism, such as the notion of "occult economies." An argument is made not only for value's dynamic and changeable nature but also for the necessity to appreciate instances of its subversion with destructive effects. The article underlines, therefore, how such subversions of value, in various forms, is in line with Tsing's (2015 general argument that critical explorations of capitalism and regimes of valuation and production are best undertaken in peri-capitalist zones- such as urban and rural Mozambique.

  11. Override of spontaneous respiratory pattern generator reduces cardiovascular parasympathetic influence

    Science.gov (United States)

    Patwardhan, A. R.; Vallurupalli, S.; Evans, J. M.; Bruce, E. N.; Knapp, C. F.

    1995-01-01

    We investigated the effects of voluntary control of breathing on autonomic function in cardiovascular regulation. Variability in heart rate was compared between 5 min of spontaneous and controlled breathing. During controlled breathing, for 5 min, subjects voluntarily reproduced their own spontaneous breathing pattern (both rate and volume on a breath-by-breath basis). With the use of this experimental design, we could unmask the effects of voluntary override of the spontaneous respiratory pattern generator on autonomic function in cardiovascular regulation without the confounding effects of altered respiratory pattern. Results from 10 subjects showed that during voluntary control of breathing, mean values of heart rate and blood pressure increased, whereas fractal and spectral powers in heart rate in the respiratory frequency region decreased. End-tidal PCO2 was similar during spontaneous and controlled breathing. These results indicate that the act of voluntary control of breathing decreases the influence of the vagal component, which is the principal parasympathetic influence in cardiovascular regulation.

  12. A Novel Approach for Association Rule Mining using Pattern Generation

    Directory of Open Access Journals (Sweden)

    Deepa S. Deshpande

    2014-10-01

    Full Text Available Data mining has become a process of significant interest in recent years due to explosive rate of the accumulation of data. It is used to discover potentially valuable implicit knowledge from the large transactional databases. Association rule mining is one of the well known techniques of data mining. It typically aims at discovering associations between attributes in the large databases. The first and the most influential traditional algorithm for association rule discovery is Apriori. Multiple scans of database, generation of large number of candidates item set and discovery of interesting rules are the main challenging issues for the improvement of Apriori algorithm. Therefore in order to decrease the multiple scanning of database, a new method of association rule mining using pattern generation is proposed in this paper. This method involves three steps. First, patterns are generated using items from the transaction database. Second, frequent item set is obtained using these patterns. Finally association rules are derived. The performance of this method is evaluated with the traditional Apriori algorithm. It shows that behavior of the proposed method is much more similar to Apriori algorithm with less memory space and reduction in multiple times scanning of database. Thus it is more efficient than the traditional Apriori algorithm.

  13. Towards multifocal ultrasonic neural stimulation: pattern generation algorithms.

    Science.gov (United States)

    Hertzberg, Yoni; Naor, Omer; Volovick, Alexander; Shoham, Shy

    2010-10-01

    Focused ultrasound (FUS) waves directed onto neural structures have been shown to dynamically modulate neural activity and excitability, opening up a range of possible systems and applications where the non-invasiveness, safety, mm-range resolution and other characteristics of FUS are advantageous. As in other neuro-stimulation and modulation modalities, the highly distributed and parallel nature of neural systems and neural information processing call for the development of appropriately patterned stimulation strategies which could simultaneously address multiple sites in flexible patterns. Here, we study the generation of sparse multi-focal ultrasonic distributions using phase-only modulation in ultrasonic phased arrays. We analyse the relative performance of an existing algorithm for generating multifocal ultrasonic distributions and new algorithms that we adapt from the field of optical digital holography, and find that generally the weighted Gerchberg-Saxton algorithm leads to overall superior efficiency and uniformity in the focal spots, without significantly increasing the computational burden. By combining phased-array FUS and magnetic-resonance thermometry we experimentally demonstrate the simultaneous generation of tightly focused multifocal distributions in a tissue phantom, a first step towards patterned FUS neuro-modulation systems and devices.

  14. Pattern generation requirements for mask making beyond 130 nm

    Science.gov (United States)

    Abboud, Frank E.; Gesley, Mark A.; Maldonado, Juan R.

    1998-06-01

    It is commonly accepted in the semiconductor industry that optical lithography will be the most cost-effective solution for 150 nm and 130 nm device generations. Some selected layers at the 130 nm device generation may be produced using electron-beam direct-write or x-ray during the development phase. However, for the production phase, it is expected that 193 nm optical lithography with reticle enhancement techniques such as optical proximity correction (OPC) and phase shift masks (PSM) will be the technology of choice. What about post 193 nm. The range of solutions is more diverse and a clear winner has not yet emerged. The topic, however, is becoming more visible and has taken a prominent place in technical conferences in the past year. The five leading potential alternatives to optical lithography are proximity x-ray, e-beam projection (EBP), extended UV (EUV), ion projection lithography (IPL), and e-beam direct write. The search for the right answer will most likely continue for a few years, and possibly more than one alternative will emerge as an effective solution at and below 100 nm. All of the alternatives, with the exception of e-beam direct write, have one thing in common, the mask. Except for proximity x- ray, all solutions at present envision a 4x reduction of the mask-to-wafer image plane. Instead of chrome-coated quartz, a silicon wafer substrate is used. Aside from patterning, mask fabrication varies depending on the lithography absorbing substrate, and EUV requires a reflective multilayer stack. Most key lithography requirements needed to pattern the imaging layer are common to all of the candidates, at least for the reduction methods. For x-ray lithography, the requirements are significantly more stringent but at a smaller field. This paper will consolidate the requirements of the various types of masks from a pattern generation point of view and will focus on the pattern generation tool requirements to meet those mask requirements. In addition, it

  15. Distributed generation and centralized power system in Thailand

    DEFF Research Database (Denmark)

    Sukkumnoed, Decharut

    The paper examines and discusses conflicts between the development of distributed power and centralized power system in Thailand.......The paper examines and discusses conflicts between the development of distributed power and centralized power system in Thailand....

  16. Distributed generation and centralized power system in Thailand

    DEFF Research Database (Denmark)

    Sukkumnoed, Decharut

    2004-01-01

    The paper examines and discusses conflicts between the development of distributed power and centralized power system.......The paper examines and discusses conflicts between the development of distributed power and centralized power system....

  17. BUILDOUT AND UPGRADE OF CENTRAL EMERGENCY GENERATOR SYSTEM, GENERATOR 3 AND 4 ELECTRICAL INSTALLATION

    Energy Technology Data Exchange (ETDEWEB)

    Gary D. Seifert; G. Shawn West; Kurt S. Myers; Jim Moncur

    2006-07-01

    SECTION 01000—SUMMARY OF WORK PART 1—GENERAL 1.1 SUMMARY The work to be performed under this project consists of providing the labor, equipment, and materials to perform "Buildout and Upgrade of Central Emergency Generator System, Generator 3 and 4 Electrical Installation" for the National Aeronautics and Space Administration at the Dryden Flight Research Center (NASA/DFRC), Edwards, California 93523. All modifications to existing substations and electrical distribution systems are the responsibility of the contractor. It is the contractor’s responsibility to supply a complete and functionally operational system. The work shall be performed in accordance with these specifications and the related drawings. The work of this project is defined by the plans and specifications contained and referenced herein. This work specifically includes but is not limited to the following: Scope of Work - Installation 1. Install all electrical wiring and controls for new generators 3 and 4 to match existing electrical installation for generators 1 and 2 and in accordance with drawings. Contractor shall provide as-built details for electrical installation. 2. Install battery charger systems for new generators 3 and 4 to match existing battery charging equipment and installation for generators 1 and 2. This may require exchange of some battery charger parts already on-hand. Supply power to new battery chargers from panel and breakers as shown on drawings. Utilize existing conduits already routed to generators 3 and 4 to field route the new wiring in the most reasonable way possible. 3. Install electrical wiring for fuel/lube systems for new generators 3 and 4 to match existing installation for generators 1 and 2. Supply power to lube oil heaters and fuel system (day tanks) from panel and breakers as shown on drawings. Utilize existing conduits already routed to generators 3 and 4 to field route the new wiring in the most reasonable way possible. Add any conduits necessary to

  18. Evaluating functional roles of phase resetting in generation of adaptive human bipedal walking with a physiologically based model of the spinal pattern generator.

    OpenAIRE

    Aoi, Shinya; Ogihara, Naomichi; Funato, Tetsuro; Sugimoto, Yasuhiro; Tsuchiya, Kazuo

    2010-01-01

    The central pattern generators (CPGs) in the spinal cord strongly contribute to locomotor behavior. To achieve adaptive locomotion, locomotor rhythm generated by the CPGs is suggested to be functionally modulated by phase resetting based on sensory afferent or perturbations. Although phase resetting has been investigated during fictive locomotion in cats, its functional roles in actual locomotion have not been clarified. Recently, simulation studies have been conducted to examine the roles of...

  19. Stochastic Generation of Wind Patterns over Lake Geneva

    Science.gov (United States)

    Barry, D. A.; Barry, C. E.; Razmi, A. M.; Lemmin, U.; Le Dantec, N.

    2011-12-01

    stochastic generator of wind-pattern indices, i.e., the INAR(1) model produces a sequence of integers, each of which corresponds to a wind pattern. For a given index, the aforementioned binned COSMO wind fields were sampled randomly to produce the stochastic wind-field sequence.

  20. An Assessment of Future Patterns of Security in Central Asia

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Since the disintegration of the Soviet Union in the early 1990s, various social problems left over have emerged in some Central Asian states, thus threatening social stability in the region. Under globalization, the former Soviet republics in Central Asia have made great efforts to develop constructive relations with others in the hope of strengthening their security. However, the threat of terrorism, extremism and separatism still exists. These non-traditional security issues play a role in current international politics, and the countries in the region are trylng to meet new challenges.

  1. Simplified Process for Manufacturing Macroscale Patterns to Enhance Voltage Generation by a Triboelectric Generator

    Directory of Open Access Journals (Sweden)

    Jun-Ho Yang

    2015-11-01

    Full Text Available This paper proposes a simple, yet effective and affordable, manufacturing process to enhance the overall efficiency of voltage generation by a triboelectric generator (TEG using 3D printers for energy-harvesting applications. The proposed method can be classified as macroscale surface patterning, in contrast to micro- and nanoscale patterning of TEG proposed in previous studies. Experiments were conducted using a designed test-bed system that allowed the control of external factors, such as the magnitude and frequency of the frictional force and the relative humidity, and an output voltage increase of up to 67% was obtained from a TEG with macroscale patterns that increased the surface area by 14%. The peak voltage generated by the TEG was as high as 18 V, and the addition of a designed analog circuit that uses no external power enabled storage of a DC voltage of 0.4 V. In comparison with previous methods that employ micro- or nanoscale patterns, the proposed patterning method is faster and more suitable for mass production.

  2. Generation of Viable Cell and Biomaterial Patterns by Laser Transfer

    Science.gov (United States)

    Ringeisen, Bradley

    2001-03-01

    In order to fabricate and interface biological systems for next generation applications such as biosensors, protein recognition microarrays, and engineered tissues, it is imperative to have a method of accurately and rapidly depositing different active biomaterials in patterns or layered structures. Ideally, the biomaterial structures would also be compatible with many different substrates including technologically relevant platforms such as electronic circuits or various detection devices. We have developed a novel laser-based technique, termed matrix assisted pulsed laser evaporation direct write (MAPLE DW), that is able to direct write patterns and three-dimensional structures of numerous biologically active species ranging from proteins and antibodies to living cells. Specifically, we have shown that MAPLE DW is capable of forming mesoscopic patterns of living prokaryotic cells (E. coli bacteria), living mammalian cells (Chinese hamster ovaries), active proteins (biotinylated bovine serum albumin, horse radish peroxidase), and antibodies specific to a variety of classes of cancer related proteins including intracellular and extracellular matrix proteins, signaling proteins, cell cycle proteins, growth factors, and growth factor receptors. In addition, patterns of viable cells and active biomolecules were deposited on different substrates including metals, semiconductors, nutrient agar, and functionalized glass slides. We will present an explanation of the laser-based transfer mechanism as well as results from our recent efforts to fabricate protein recognition microarrays and tissue-based microfluidic networks.

  3. The generation of vertebral segmental patterning in the chick embryo.

    Science.gov (United States)

    Senthinathan, Biruntha; Sousa, Cátia; Tannahill, David; Keynes, Roger

    2012-06-01

    We have carried out a series of experimental manipulations in the chick embryo to assess whether the notochord, neural tube and spinal nerves influence segmental patterning of the vertebral column. Using Pax1 expression in the somite-derived sclerotomes as a marker for segmentation of the developing intervertebral disc, our results exclude such an influence. In contrast to certain teleost species, where the notochord has been shown to generate segmentation of the vertebral bodies (chordacentra), these experiments indicate that segmental patterning of the avian vertebral column arises autonomously in the somite mesoderm. We suggest that in amniotes, the subdivision of each sclerotome into non-miscible anterior and posterior halves plays a critical role in establishing vertebral segmentation, and in maintaining left/right alignment of the developing vertebral elements at the body midline.

  4. Distinct rhythmic locomotor patterns can be generated by a simple adaptive neural circuit: biology, simulation, and VLSI implementation.

    Science.gov (United States)

    Ryckebusch, S; Wehr, M; Laurent, G

    1994-12-01

    Rhythmic motor patterns can be induced in leg motor neurons of isolated locust thoracic ganglia by bath application of pilocarpine. We observed that the relative phases of levators and depressors differed in the three thoracic ganglia. Assuming that the central pattern generating circuits underlying these three segmental rhythms are probably very similar, we developed a simple model circuit that can produce any one of the three activity patterns and characteristic phase relationships by modifying a single synaptic weight. We show results of a computer simulation of this circuit using the neuronal simulator NeuraLOG/Spike. We built and tested an analog VLSI circuit implementation of this model circuit that exhibits the same range of "behaviors" as the computer simulation. This multidisciplinary strategy will be useful to explore the dynamics of central pattern generating networks coupled to physical actuators, and ultimately should allow the design of biologically realistic walking robots.

  5. Space-Time Analysis of Crime Patterns in Central London

    Science.gov (United States)

    Cheng, T.; Williams, D.

    2012-07-01

    Crime continues to cast a shadow over citizen well-being in big cities today, while also imposing huge economic and social costs. Timely understanding of how criminality emerges and how crime patterns evolve is crucial to anticipating crime, dealing with it when it occurs and developing public confidence in the police service. Every day, about 10,000 crime incidents are reported by citizens, recorded and geo-referenced in the London Metropolitan Police Service Computer Aided Dispatch (CAD) database. The unique nature of this dataset allows the patterns to be explored at particularly fine temporal granularity and at multiple spatial resolutions. This study provides a framework for the exploratory spatio-temporal analysis of crime patterns that combines visual inquiry tools (interactive animations, space-time cubes and map matrices) with cluster analysis (spatial-temporal scan statistics and the self-organizing map). This framework is tested on the CAD dataset for the London Borough of Camden in March 2010. Patterns of crime through space and time are discovered and the clustering methods were evaluated on their ability to facilitate the discovery and interpretation of these patterns.

  6. Multi-neuronal refractory period adapts centrally generated behaviour to reward.

    Directory of Open Access Journals (Sweden)

    Christopher A Harris

    Full Text Available Oscillating neuronal circuits, known as central pattern generators (CPGs, are responsible for generating rhythmic behaviours such as walking, breathing and chewing. The CPG model alone however does not account for the ability of animals to adapt their future behaviour to changes in the sensory environment that signal reward. Here, using multi-electrode array (MEA recording in an established experimental model of centrally generated rhythmic behaviour we show that the feeding CPG of Lymnaea stagnalis is itself associated with another, and hitherto unidentified, oscillating neuronal population. This extra-CPG oscillator is characterised by high population-wide activity alternating with population-wide quiescence. During the quiescent periods the CPG is refractory to activation by food-associated stimuli. Furthermore, the duration of the refractory period predicts the timing of the next activation of the CPG, which may be minutes into the future. Rewarding food stimuli and dopamine accelerate the frequency of the extra-CPG oscillator and reduce the duration of its quiescent periods. These findings indicate that dopamine adapts future feeding behaviour to the availability of food by significantly reducing the refractory period of the brain's feeding circuitry.

  7. A Hierarchical Connectionist Central Pattern Generator Model for Controlling Three-dimensional Gaits of Snake-like Robots%面向蛇形机器人的三维步态控制的层次化联结中枢模式生成器模型

    Institute of Scientific and Technical Information of China (English)

    杨贵志; 马书根; 李斌; 王明辉

    2013-01-01

    提高蛇形机器人的三维运动控制能力是提高蛇形机器人环境适应能力的关键之一.虽然联结中枢模式生成器(Connectionist central pattern generator,CCPG)模型具有复杂度小、适合硬件实现等优点,但是目前的CCPG模型难以生成相位协调的多自由度运动的控制信号,从而限制了它的三维步态控制能力.本文根据生物CPG机制的分层结构和运动神经元的功能,提出一个有层次化结构的CCPG (Hierarchical CCPG,HCCPG)模型.HCCPG模型由基本节律信号生成层、模式形成层、运动信号调整层这三个部分组成.运动信号调整层的运动神经元能够独立地对模式形成层的输出信号的幅值、相位等进行调整,从而较好地解决了CCPG模型难以生成相位协调的多自由度运动控制信号的问题.HCCPG模型具有步态控制能力强、复杂度小、有良好的扩展性等优点,从而适合用于控制三维步态.在HCCPG模型的基础上提出一个三维步态控制方法.仿真验证了这个控制方法的有效性.

  8. Anthropogenic soils in central Amazonia: farmers’ practices, agrobiodiversity and land-use patterns

    NARCIS (Netherlands)

    Braga Junqueira, A.

    2015-01-01

    Keywords: Terra Preta; Amazonian Dark Earths; Shifting cultivation; Homegardens; Intensification; Diversification; Smallholder farming. André Braga Junqueira (2015). Anthropogenic soils in central Amazonia: farmers’ practices, agrobiodiversity and land-use patterns. PhD thesis, Wagening

  9. Bases of motifs for generating repeated patterns with wild cards.

    Science.gov (United States)

    Pisanti, Nadia; Crochemore, Maxime; Grossi, Roberto; Sagot, Marie-France

    2005-01-01

    Motif inference represents one of the most important areas of research in computational biology, and one of its oldest ones. Despite this, the problem remains very much open in the sense that no existing definition is fully satisfying, either in formal terms, or in relation to the biological questions that involve finding such motifs. Two main types of motifs have been considered in the literature: matrices (of letter frequency per position in the motif) and patterns. There is no conclusive evidence in favor of either, and recent work has attempted to integrate the two types into a single model. In this paper, we address the formal issue in relation to motifs as patterns. This is essential to get at a better understanding of motifs in general. In particular, we consider a promising idea that was recently proposed, which attempted to avoid the combinatorial explosion in the number of motifs by means of a generator set for the motifs. Instead of exhibiting a complete list of motifs satisfying some input constraints, what is produced is a basis of such motifs from which all the other ones can be generated. We study the computational cost of determining such a basis of repeated motifs with wild cards in a sequence. We give new upper and lower bounds on such a cost, introducing a notion of basis that is provably contained in (and, thus, smaller) than previously defined ones. Our basis can be computed in less time and space, and is still able to generate the same set of motifs. We also prove that the number of motifs in all bases defined so far grows exponentially with the quorum, that is, with the minimal number of times a motif must appear in a sequence, something unnoticed in previous work. We show that there is no hope to efficiently compute such bases unless the quorum is fixed.

  10. Pattern recognition receptors and central nervous system repair.

    Science.gov (United States)

    Kigerl, Kristina A; de Rivero Vaccari, Juan Pablo; Dietrich, W Dalton; Popovich, Phillip G; Keane, Robert W

    2014-08-01

    Pattern recognition receptors (PRRs) are part of the innate immune response and were originally discovered for their role in recognizing pathogens by ligating specific pathogen associated molecular patterns (PAMPs) expressed by microbes. Now the role of PRRs in sterile inflammation is also appreciated, responding to endogenous stimuli referred to as "damage associated molecular patterns" (DAMPs) instead of PAMPs. The main families of PRRs include Toll-like receptors (TLRs), Nod-like receptors (NLRs), RIG-like receptors (RLRs), AIM2-like receptors (ALRs), and C-type lectin receptors. Broad expression of these PRRs in the CNS and the release of DAMPs in and around sites of injury suggest an important role for these receptor families in mediating post-injury inflammation. Considerable data now show that PRRs are among the first responders to CNS injury and activation of these receptors on microglia, neurons, and astrocytes triggers an innate immune response in the brain and spinal cord. Here we discuss how the various PRR families are activated and can influence injury and repair processes following CNS injury.

  11. Repetition rate tunable ultra-short optical pulse generation based on electrical pattern generator

    Institute of Scientific and Technical Information of China (English)

    Xin Fu; Hongming Zhang; Meng Yan; Minyu Yao

    2009-01-01

    @@ An actively mode-locked laser with tunable repetition rate is proposed and experimentally demonstrated based on a programmable electrical pattern generator.By changing the repetition rate of the electrical patterns applied on the in-cavity modulator, the repetition rate of the output optical pulse sequences changes accordingly while the pulse width of the optical pulse train remains almost constant.In other words, the output ultra-short pulse train has a tunable duty cycle.In a proof-of-principle experiment, optical pulses with repetition rates of 10, 5, 2.5 and 1.25 GHz are obtained by adjusting the electrical pattern applied on the in-cavity modulator while their pulse widths remain almost unchanged.

  12. Assessing dissolved methane patterns in central New York groundwater

    Directory of Open Access Journals (Sweden)

    Lauren E. McPhillips

    2014-07-01

    New hydrological insights for this region: There was no significant difference between methane concentrations in valleys versus upslope locations, in water wells less than or greater than 1 km from a conventional gas well, and across different geohydrologic units. Methane concentrations were significantly higher in groundwater dominated by sodium chloride or sodium bicarbonate compared with groundwater dominated by calcium bicarbonate, indicating bedrock interactions and lengthy residence times as controls. A multivariate regression model of dissolved methane using only three variables (sodium, hardness, and barium explained 77% of methane variability, further emphasizing the dominance of geochemistry and hydrogeology as controls on baseline methane patterns.

  13. Research on Optimal Development Pattern of Yunnan Central Economic Region

    Institute of Scientific and Technical Information of China (English)

    Diego Salmero; Suman Rana

    2012-01-01

    By the case study on the Urban Agglomeration Plan of Yunnan Central Economic Region (YCER), which is jointly made by Chinese and Swiss scholars, with the adoption of GIS and traditional urban planning methods, this paper uses multiple scenarios to analyze four development models of "Scattered Yunnan," "Regional Yunnan," "Metropolitan Yunnan" and "Network Yunnan." It also explores the relatively rational scenarios for the future development of YCER, i.e., up to 2030, the development model of YCER will be "Regional," and after 2030 it will be "Network." In this way, YCER will be developed stably and methodically, and finally achieve the unification of ecological safety, intensified energy and resources, as well as prosperous economy.

  14. A central role for the notochord in vertebral patterning.

    Science.gov (United States)

    Fleming, Angeleen; Keynes, Roger; Tannahill, David

    2004-02-01

    The vertebrates are defined by their segmented vertebral column, and vertebral periodicity is thought to originate from embryonic segments, the somites. According to the widely accepted 'resegmentation' model, a single vertebra forms from the recombination of the anterior and posterior halves of two adjacent sclerotomes on both sides of the embryo. Although there is supporting evidence for this model in amniotes, it remains uncertain whether it applies to all vertebrates. To explore this, we have investigated vertebral patterning in the zebrafish. Surprisingly, we find that vertebral bodies (centra) arise by secretion of bone matrix from the notochord rather than somites; centra do not form via a cartilage intermediate stage, nor do they contain osteoblasts. Moreover, isolated, cultured notochords secrete bone matrix in vitro, and ablation of notochord cells at segmentally reiterated positions in vivo prevents the formation of centra. Analysis of fss mutant embryos, in which sclerotome segmentation is disrupted, shows that whereas neural arch segmentation is also disrupted, centrum development proceeds normally. These findings suggest that the notochord plays a key, perhaps ancient, role in the segmental patterning of vertebrae.

  15. Identifying Landscape Areas Prone to Generating Storm Runoff in Central New York Agricultural Fields

    Science.gov (United States)

    Hofmeister, K.; Walter, M. T.

    2015-12-01

    Nonpoint source (NPS) pollution continues to be a leading cause of surface water degradation, especially in agricultural areas. In humid regions where variable source area (VSA) hydrology dominates storm runoff, NPS pollution is generated where VSAs coincide with polluting activities. Mapping storm runoff risks could allow for more precise and informed targeting of NPS pollution mitigation practices in agricultural landscapes. Topographic wetness indices (TWI) provide good approximations of relative soil moisture patterns and relative storm runoff risks. Simulation models are typically used in conjunction with TWIs to quantify VSA behavior. In this study we use empirically derived relationships between TWI values, volumetric water content (VWC) and rainfall frequencies to develop runoff probability maps. Rainfall and soil VWC were measured across regionally representative agricultural areas in central New York over three years (2012-2015) to determine the volume of runoff generated from agricultural fields in the area. We assumed the threshold for storm runoff occurs when the combination of antecedent soil water and rainfall are sufficient to saturate the soil. We determined that approximately 50% of the storm runoff volume is generated from 10% of the land area during spring, summer, and autumn seasons, while the risk of storm runoff generation is higher in the spring and autumn seasons than in the summer for the same area of land.

  16. Generation of Focused Electric Field Patterns at Dielectric Surfaces

    Science.gov (United States)

    Olofsson, Jessica; Levin, Mikael; Strömberg, Anette; Weber, Stephen G.; Ryttsén, Frida; Orwar, Owe

    2006-01-01

    We here report on a concept for creating well-defined electric field gradients between the boundaries of capillary electrode (a capillary of a nonconducting material equipped with an interior metal electrode) outlets, and dielectric surfaces. By keeping a capillary electrode opening close to a boundary between a conducting solution and a nonconducting medium, a high electric field can be created close to the interface by field focusing effects. By varying the inner and outer diameters of the capillary, the span of electric field strengths and the field gradient obtained can be controlled, and by varying the slit height between the capillary rim and the surface, or the applied current, the average field strength and gradient can be varied. Field focusing effects and generation of electric field patterns were analyzed using finite element method simulations. We experimentally verified the method by electroporation of a fluorescent dye (fluorescein diphosphate) into adherent, monolayered cells (PC-12 and WSS-1) and obtained a pattern of fluorescent cells corresponding to the focused electric field. PMID:16013887

  17. Learning Techniques for Automatic Test Pattern Generation using Boolean Satisfiability

    Directory of Open Access Journals (Sweden)

    Liu Xin

    2013-07-01

    Full Text Available Automatic Test Pattern Generation (ATPG is one of the core problems in testing of digital circuits. ATPG algorithms based on Boolean Satisfiability (SAT turned out to be very powerful, due to great advances in the performance of satisfiability solvers for propositional logic in the last two decades. SAT-based ATPG clearly outperforms classical approaches especially for hard-to-detect faults. But its inaccessibility of structural information and don’t care, there exists the over-specification problem of input patterns. In this paper we present techniques to delve into an additional layer to make use of structural properties of the circuit and value justification relations to a generic SAT algorithm. It joins binary decision graphs (BDD and SAT techniques to improve the efficiency of ATPG. It makes a study of inexpensive reconvergent fanout analysis of circuit to gather information on the local signal correlation by using BDD learning, then uses the above learned information to restrict and focus the overall search space of SAT-based ATPG. The learning technique is effective and lightweight. Experimental results show the effectiveness of the approach.

  18. Two-stage Turing model for generating pigment patterns on the leopard and the jaguar

    Science.gov (United States)

    Liu, R. T.; Liaw, S. S.; Maini, P. K.

    2006-07-01

    Based on the results of phylogenetic analysis, which showed that flecks are the primitive pattern of the felid family and all other patterns including rosettes and blotches develop from it, we construct a Turing reaction-diffusion model which generates spot patterns initially. Starting from this spotted pattern, we successfully generate patterns of adult leopards and jaguars by tuning parameters of the model in the subsequent phase of patterning.

  19. Spatial change analysis of paddy cropping pattern using MODIS time series imagery in Central Java

    Science.gov (United States)

    Arif Fatoni, Muhammad; Dwi Nugroho, Kreshna; Fatikhunnada, Alvin; Liyantono; Setiawan, Yudi

    2017-01-01

    Central Java had the diverse paddy field cropping patterns and it was influenced by several factors such as water availability, land condition, paddy fields ownership, and local culture. This research was aimed to analyze dynamic changes of paddy cropping pattern using MODIS imagery (MOD13Q1 16-day composite from 2001 to 2015). This research used k-means clustering algorithm for classified cropping pattern in Central Java based on similarity pattern of annual data from vegetation index. The result of this research classified cropping pattern become a main class and produced 15 maps of distribution cropping patterns (from 2001 to 2015). The result also divided Central Java’s paddy fields become 2 section (constant and change) based on cropping pattern that majority was caused by water availability. This research got the better accuracy (77.67%) of cropping pattern than long time series analysis from previous research. Although some classes successfully obtained upon annual time series analysis, MODIS still difficult to detect mixed crop pattern.

  20. A Cyclic Inhibitory Central Pattern Generator Control Method Integrated with Mechanical Oscillators for Snake Robots%融合机械元的蛇形机器人循环抑制中枢模式发生器控制方法

    Institute of Scientific and Technical Information of China (English)

    唐超权; 王明辉; 李斌; 马书根

    2013-01-01

    To solve the problem that there is no basis for choosing control signals and sensor information for central pattern generator (CPG) control of snake robots, a cyclic inhibitory CPG control method with mechanical oscillators is proposed. Firstly, the mechanical oscillators reformed from snake robot dynamical equations are introduced into the cyclic inhibitory CPG model. Secondly, an improved Matsuoka neuron is proposed so that the neuron and mechanical oscillator can be expressed in a uniform way. Thirdly, the relationship of parameters in the cyclic inhibitory CPG model with mechanical oscillators is illustrated, and the relationship expression of the control signal and sensor information for snake robots and the CPG states is given. Finally, the proposed method is verified with simulation, and the simulation results are analyzed. In this method, there are clear definitions for the control signals and sensor information of snake robots, and the computation complexity of CPG is decreased because neuron computation in CPG is replaced with physical structure of mechanical oscillators.%针对蛇形机器人中枢模式发生器(CPG)控制中控制信号以及传感信息缺少选择依据的问题,提出了一种融合了机械元的循环抑制CPG控制方法.首先,将蛇形机器人本体动力学方程改造为机械元引入循环抑制CPG模型.其次,提出了改进的Matsuoka神经元,从而使得神经元与机械元具有一致的表达形式.再次,分析了融入机械元的循环抑制CPG模型中的参数关系,并给出了控制信号和传感信息与CPG状态量关系的表达式.最后,利用仿真对所提出的方法进行了验证,并对产生结果进行了分析.该方法中蛇形机器人的控制信号与传感信息都具有明确的定义,且由于用机械元的物理结构代替了神经元的计算,降低了CPG的计算量.

  1. Real-time Walking Pattern Generation for a Biped Robot with Hybrid CPG-ZMP Algorithm

    Directory of Open Access Journals (Sweden)

    Bin He

    2014-10-01

    Full Text Available Biped robots have better mobility than conventional wheeled robots. The bio-inspired method based on a central pattern generator (CPG can be used to control biped robot walking in a manner like human beings. However, to achieve stable locomotion, it is difficult to modulate the parameters for the neural networks to coordinate every degree of freedom of the walking robot. The zero moment point (ZMP method is very popular for the stability control of biped robot walking. However, the reference trajectories have low energy efficiency, lack naturalness and need significant offline calculation. This paper presents a new method for biped real-time walking generation using a hybrid CPG-ZMP control algorithm. The method can realize a stable walking pattern by combining the ZMP criterion with rhythmic motion control. The CPG component is designed to generate the desired motion for each robot joint, which is modulated by phase resetting according to foot contact information. By introducing the ZMP location, the activity of the CPG output signal is adjusted to coordinate the limbs’ motion and allow the robot to maintain balance during the process of locomotion. The numerical simulation results show that, compared with the CPG method, the new hybrid CPG-ZMP algorithm can enhance the robustness of the CPG parameters and improve the stability of the robot. In addition, the proposed algorithm is more energy efficient than the ZMP method. The results also demonstrate that the control system can generate an adaptive walking pattern through interactions between the robot, the CPG and the environment.

  2. A Walking Rehabilitation System Using Electrical Stimulation Based on Central Pattern Generator Control: Design and Experiment%基于中枢模式发生器控制的电刺激步行康复系统设计与实验

    Institute of Scientific and Technical Information of China (English)

    王颖; 张定国

    2012-01-01

    研发功能性电刺激(FES)康复系统来实现下肢瘫痪病人的行走运动.控制器采用基于中枢模式发生器(CPG)的仿生控制机理.针对基于递归神经振荡器的CPG模型,研究关键参数(激励性输入、时间常数、感觉反馈、输出阈值)对CPG输出幅值、频率、相位以及占空比的影响.建立包含12个神经元的CPG网络,以控制双腿的4个关节(左/右髋关节和膝关节)和八组肌群(左/右髂腰肌、臀大肌、股直肌和腘绳肌).所搭建的实验系统和平台,包括悬吊减重系统、助行系统、电刺激系统和运动检测系统.在正常受试者参与的实验中,受试者在CPG控制的电刺激作用下产生非自主行走运动.实验结果表明,受试者双腿的髋关节和膝关节角度与正常人自主行走时的数据达到定性吻合,验证所设计的CPG控制器在FES康复系统中的可行性与有效性.%A walking rehabilitation system for paralyzed patients using functional electrical stimulation ( FES) technique was developed in this work. A kind of biological motor control mechanism, central pattern generator (CPG) , was adopted as the controller of the system. Targeting the CPG model named as recurrent neural oscillator, the effects of CPG parameters ( excitation input, time constant, sensory feedback, and output threshold) on output amplitude, frequency, phase, and duty cycle were studied. The CPG network containing 12 neurons was developed in order to control four joints (left/right hip joints and knee joints) with eight muscle groups ( left/right iliopsoas, glutaeus maximus, rectus femoris, and hamstrings) of lower limbs. FES experimental system and platform is constructed, which includes suspension system, treadmill, FES system and motion measurement system. Experiments were conducted on healthy subjects to generate the involuntary walking movements via FES based on CPG control. The experimental results show that the hip and knee joint angles measured

  3. Solar central electric power generation - A baseline design

    Science.gov (United States)

    Powell, J. C.

    1976-01-01

    The paper presents the conceptual technical baseline design of a solar electric power plant using the central receiver concept, and derives credible cost estimates from the baseline design. The major components of the plant - heliostats, tower, receiver, tower piping, and thermal storage - are discussed in terms of technical and cost information. The assumed peak plant output is 215 MW(e), over 4000 daylight hours. The contribution of total capital investment to energy cost is estimated to be about 55 mills per kwh in mid-1974 dollars.

  4. Decreasing overweight and central fat patterning with Westernization among the Inuit in Greenland and Inuit migrants

    DEFF Research Database (Denmark)

    Bjerregaard, P; Jørgensen, M E; Andersen, S

    2002-01-01

    OBJECTIVE: To analyse overweight, obesity and central fat patterning among the Inuit of Greenland and Inuit migrants in Denmark and their relation to Westernization. DESIGN: Cross-sectional, population-based epidemiological study. SUBJECTS: A total of 2046 adult Greenlanders (Inuit), 61% of those...... women. Adjusted for BMI, age and Inuit heritage waist circumference decreased with Westernization (among women), while hip circumference did not change. The differences were particularly pronounced for migrants compared with residents of Greenland. CONCLUSION: BMI and central fat patterning decrease...

  5. Simultaneous measurement of membrane potential changes in multiple pattern generating neurons using voltage sensitive dye imaging.

    Science.gov (United States)

    Städele, Carola; Andras, Peter; Stein, Wolfgang

    2012-01-15

    Optical imaging using voltage-sensitive dyes (VSDs) is a promising technique for the simultaneous activity recording of many individual neurons. While such simultaneous recordings are critical for the understanding of the integral functionality of neural systems, functional interpretations on a single neuron level are difficult without knowledge of the connectivity of the underlying circuit. Central pattern generating circuits, such as the pyloric and gastric mill circuits in the stomatogastric ganglion (STG) of crustaceans, allow such investigations due to their well-known connectivities and have already contributed much to our understanding of general neuronal mechanisms. Here we present for the first time simultaneous optical recordings of the pattern generating neurons in the STG of two crustacean species using bulk loading of the VSD di-4-ANEPPS. We demonstrate the recording of firing activities and synaptic interactions of the circuit neurons as well as inter-circuit interactions in their functional context, i.e. without artificial stimulation. Neurons could be uniquely identified using simple event-triggered averaging. We tested this technique in two different species of crustaceans (lobsters and crabs), since several crustacean species are used for studying motor pattern generation. The signal-to-noise ratio of the optical signal was high enough in both species to derive phase-relationship between the network neurons, as well as action potentials and excitatory and inhibitory postsynaptic potentials. We argue that imaging of neural networks with identifiable neurons with well-known connectivity, like in the STG, is crucial for the understanding of emergence of network functionality.

  6. Anthropogenic soils in central Amazonia: farmers’ practices, agrobiodiversity and land-use patterns

    OpenAIRE

    2015-01-01

    Keywords: Terra Preta; Amazonian Dark Earths; Shifting cultivation; Homegardens; Intensification; Diversification; Smallholder farming. André Braga Junqueira (2015). Anthropogenic soils in central Amazonia: farmers’ practices, agrobiodiversity and land-use patterns. PhD thesis, Wageningen University, The Netherlands, with summary in English, 163 pp. Rural Amazonia is increasingly experiencing environmental and socio-economic changes that directly affect smallholder farmers, with ...

  7. Generation of 1D interference patterns of Bloch surface waves

    Science.gov (United States)

    Kadomina, E. A.; Bezus, E. A.; Doskolovich, L. L.

    2016-09-01

    Interference patterns of Bloch surface waves with a period that is significantly less than the wavelength of incident radiation are formed using dielectric diffraction gratings located on the surface of photonic crystal. The simulation based on electromagnetic diffraction theory is used to demonstrate the possibility of high-quality interference patterns due to resonant enhancement of higher evanescent diffraction orders related to the excitation of the Bloch surface waves. The contrast of the interference patterns is close to unity, and the period is less than the period of the diffraction structure by an order of magnitude.

  8. Computer program for automatic generation of BWR control rod patterns

    Energy Technology Data Exchange (ETDEWEB)

    Taner, M.S.; Levine, S.H.; Hsia, M.Y. (Pennsylvania State Univ., University Park (United States))

    1990-01-01

    A computer program named OCTOPUS has been developed to automatically determine a control rod pattern that approximates some desired target power distribution as closely as possible without violating any thermal safety or reactor criticality constraints. The program OCTOPUS performs a semi-optimization task based on the method of approximation programming (MAP) to develop control rod patterns. The SIMULATE-E code is used to determine the nucleonic characteristics of the reactor core state.

  9. Major Dietary Patterns in Relation to General and Central Obesity among Chinese Adults

    Directory of Open Access Journals (Sweden)

    Canqing Yu

    2015-07-01

    Full Text Available Limited evidence exists for the association between diet pattern and obesity phenotypes among Chinese adults. In the present study, we analyzed the cross-sectional data from 474,192 adults aged 30–79 years from the China Kadoorie Biobank baseline survey. Food consumption was collected by an interviewer-administered questionnaire. Three dietary patterns were extracted by factor analysis combined with cluster analysis. After being adjusted for potential confounders, individuals following a traditional southern dietary pattern had the lowest body mass index (BMI and waist circumference (WC; the Western/new affluence dietary pattern had the highest BMI; and the traditional northern dietary pattern had the highest WC. Compared to the traditional southern dietary pattern in multivariable adjusted logistic models, individuals following a Western/new affluence dietary pattern had a significantly increased risk of general obesity (prevalence ratio (PR: 1.06, 95% confidence interval (CI: 1.03–1.08 and central obesity (PR: 1.07, 95% CI: 1.06–1.08. The corresponding risks for the traditional northern dietary pattern were 1.05 (1.02–1.09 and 1.17 (1.25–1.18, respectively. In addition, the associations were modified by lifestyle behaviors, and the combined effects with alcohol drinking, tobacco smoking, and physical activity were analyzed. Further prospective studies are needed to elucidate the diet-obesity relationships.

  10. Fabrication of patterned mirror modules for generating laser line beams

    Science.gov (United States)

    Lee, Changyun; Kim, Taeggyum; Hong, Sangsu; Kim, Baekyun

    2008-02-01

    A method for fabricating Ag coated beam splitter is reported. This is showing specific patterned transmittance by immersing glass substrates in the mixture of H IISO 4 and H IIO II to make negatively charged oxygen sites at silica surface and then in ethanolic solutions of AgNO 3 and butylamine. We controlled the soaking time and molar ratios of the mixture of AgNO 3 and butylamine to pattern % transmittance of electroless coated glass surface. Finally, we made a functionalized beam splitters showing step function like transmittance and applied this to make multiple laser beams for display and laser machining.

  11. Gap Junction-Mediated Signaling from Motor Neurons Regulates Motor Generation in the Central Circuits of Larval Drosophila.

    Science.gov (United States)

    Matsunaga, Teruyuki; Kohsaka, Hiroshi; Nose, Akinao

    2017-02-22

    In this study, we used the peristaltic crawling of Drosophila larvae as a model to study how motor patterns are regulated by central circuits. We built an experimental system that allows simultaneous application of optogenetics and calcium imaging to the isolated ventral nerve cord (VNC). We then investigated the effects of manipulating local activity of motor neurons (MNs) on fictive locomotion observed as waves of MN activity propagating along neuromeres. Optical inhibition of MNs with halorhodopsin3 in a middle segment (A4, A5, or A6), but not other segments, dramatically decreased the frequency of the motor waves. Conversely, local activation of MNs with channelrhodopsin2 in a posterior segment (A6 or A7) increased the frequency of the motor waves. Since peripheral nerves mediating sensory feedback were severed in the VNC preparation, these results indicate that MNs send signals to the central circuits to regulate motor pattern generation. Our results also indicate segmental specificity in the roles of MNs in motor control. The effects of the local MN activity manipulation were lost in shaking-B(2) (shakB(2) ) or ogre(2) , gap-junction mutations in Drosophila, or upon acute application of the gap junction blocker carbenoxolone, implicating electrical synapses in the signaling from MNs. Cell-type-specific RNAi suggested shakB and ogre function in MNs and interneurons, respectively, during the signaling. Our results not only reveal an unexpected role for MNs in motor pattern regulation, but also introduce a powerful experimental system that enables examination of the input-output relationship among the component neurons in this system.SIGNIFICANCE STATEMENT Motor neurons are generally considered passive players in motor pattern generation, simply relaying information from upstream interneuronal circuits to the target muscles. This study shows instead that MNs play active roles in the control of motor generation by conveying information via gap junctions to the

  12. Patterns and trends in human papillomavirus-related diseases in Central and Eastern Europe and Central Asia.

    Science.gov (United States)

    Bray, Freddie; Lortet-Tieulent, Joannie; Znaor, Ariana; Brotons, Maria; Poljak, Mario; Arbyn, Marc

    2013-12-31

    This article provides an overview of cervical cancer and other human papillomavirus (HPV)-related diseases in Central and Eastern Europe (Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Montenegro, Poland, Romania, Serbia, Slovakia, Slovenia, and the Former Yugoslav Republic [FYR] of Macedonia) and Central Asia (Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Republic of Moldova, the Russian Federation, Tajikistan, Turkmenistan, Ukraine and Uzbekistan). Despite two- to three-fold variations, cervical cancer incidence rates are high in many countries in these two regions relative to other populations on the European and Asian continents. In Central and Eastern Europe, Romania and the FYR of Macedonia had the highest rates in 2008 alongside Bulgaria, Lithuania and Serbia, while in Central Asia, rates are elevated in Kyrgyzstan (the highest rates across the regions), Kazakhstan and Armenia. In each of these countries, at least one woman in 50 develops cervical cancer before the age of 75. The high cervical cancer burden is exacerbated by a lack of effective screening and an increasing risk of death from the disease among young women, as observed in Belarus, Tajikistan, Kyrgyzstan, Armenia, Azerbaijan, Ukraine, the Russian Federation and Kazakhstan. In several countries with longstanding cancer registries of reasonable quality (Belarus, Estonia and the Russian Federation), there are clear birth cohort effects; the risk of onset of cervical cancer is increasing in successive generations of women born from around 1940-50, a general phenomenon indicative of changing sexual behaviour and increasing risk of persistent HPV infection. There are limited data for other HPV-related cancers and other diseases at present in these countries. While options for reducing the HPV-related disease burden are resource-dependent, universal HPV vaccination with enhanced screening would maximally reduce the burden of

  13. Structural pattern in central uplifts of cryptoexplosion structures as typified by Sierra Madera

    Science.gov (United States)

    Wilshire, H.G.; Howard, K.A.

    1968-01-01

    The pattern of deformation in central uplifts of Sierra Madera and other well-known cryptoexplosion structures indicates that inward as well as upward movement of strata formed the uplifts. This kind of movement is incompatible with structures not of impact origin with which they have been compared. The structural style of cryptoexplosion structures, together with features that suggest shock deformation, supports the belief that they are the eroded roots of impact craters.

  14. Groundwater chemistry patterns in the phreatic aquifer of the central Belgian coastal plain

    OpenAIRE

    Vandenbohede, A.; Lebbe, L.

    2012-01-01

    The Holocene geological evolution of the Belgian coastal plain is dominated by a transgression of the North Sea, silting up of the coastal plain and human intervention (impoldering). This has led to a typical pattern in groundwater quality which is discussed here for the central part of the coastal plain. Therefore, a database with available groundwater samples is composed. Water type according to the Stuyfzand classification is determined and different hydrosomes and their hydrochemical faci...

  15. Petrological differentiation patterns and geomorphic distribution of ferricretes in Central Africa

    OpenAIRE

    BEAUVAIS, Anicet; Roquin, C.

    1996-01-01

    Geomorphic distribution and petrological differentiation patterns of ferricretes widespread on landsurfaces were studied in the Dembia-Zemio area, southeastern Central African Republic. Four types of ferricretes are distributed on high plateaux, hillslopes and low plateaux. The main contrast corresponds to the differentiation between ferricretes of high plateaux rich in poorly hydrated minerals, hematite and kaolinite, and those covering hillslopes and low plateaux richer in hydrated minerals...

  16. Comparison Of Patterns Of Convergence Among “Emerging Markets” Of Central Europe, Eastern Europe And Central Asia

    Directory of Open Access Journals (Sweden)

    POZNAŃSKA JOANNA

    2015-03-01

    Full Text Available Based on analysis of economic growth indicators for 1989-2014, this article distinguishes the “emerging markets” of Central and Eastern Europe (with Russia included, from the other economies that fall in the broad ‘emerging markets’ category. Following the post–1989 reforms, the countries of the region share many of the same typical institutional features as other “emerging economies”, but not necessarily the associated economic outcomes. What characterizes “emerging economies” is that they grow fast enough to systematically close the distance dividing them from the advanced economies, creating convergence. Departing from this pattern, Central and Eastern Europe (and Russia have so far fallen short in terms of the growth rates, and the region as a whole has not made much progress in catching up. By more than doubling its national product Poland is the only notable exception in the region, although Slovenia may fit in the same category. At the other extreme, some of the economies actually lost two decades in terms of reducing the gaps, and some even fell further behind (e.g., Serbia, Ukraine. These findings have potentially serious implications for economic theory in general and for the presumption that globalization processes act as a unifying developmental force.

  17. FORMATION MECHANISM AND SPATIAL PATTERN OF URBAN AGGLOMERATION IN CENTRAL JILIN OF CHINA

    Institute of Scientific and Technical Information of China (English)

    QIN Gan; ZHANG Ping-yu; JIAO Bin

    2006-01-01

    Urban agglomeration is made up of cities with different sizes to be linked by traffic network in a given area, and it is an inevitable result when urbanization reaches a certain level. Taking urban agglomerationin central Jilin(UACJ) as an example, this article analyzes the formation mechanism and spatial pattern of urban agglomeration in the less-developed area. First, the dynamics of UACJ has been analyzed from the aspects of geographical condition, economic foundation, policy background, and traffic condition. Then the development process is divided into three stages-single city, city group and city cluster. Secondly, the central cities are identified from the aspects of city centrality, and the development axes are classified based on economic communication capacity. Finally, the urban agglomeration is divided into five urban economic regions in order to establish the reasonable distribution of industries.

  18. The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns

    Science.gov (United States)

    Zee, Barry M.; Dibona, Amy B.; Alekseyenko, Artyom A.; French, Christopher A.; Kuroda, Mitzi I.

    2016-01-01

    Defects in chromatin proteins frequently manifest in diseases. A striking case of a chromatin-centric disease is NUT-midline carcinoma (NMC), which is characterized by expression of NUT as a fusion partner most frequently with BRD4. ChIP-sequencing studies from NMC patients revealed that BRD4-NUT (B4N) covers large genomic regions and elevates transcription within these domains. To investigate how B4N modulates chromatin, we performed affinity purification of B4N when ectopically expressed in 293-TREx cells and quantified the associated histone posttranslational modifications (PTM) using proteomics. We observed significant enrichment of acetylation particularly on H3 K18 and of combinatorial patterns such as H3 K27 acetylation paired with K36 methylation. We postulate that B4N complexes override the preexisting histone code with new PTM patterns that reflect aberrant transcription and that epigenetically modulate the nucleosome environment toward the NMC state. PMID:27698495

  19. Bases of motifs for generating repeated patterns with wild cards

    OpenAIRE

    Pisanti, Nadia; Crochemore, Maxime; Grossi, Roberto; Sagot, Marie-France

    2005-01-01

    Motif inference represents one of the most important areas of research in computational biology, and one of its oldest ones. Despite this, the problem remains very much open in the sense that no existing definition is fully satisfying, either in formal terms, or in relation to the biological questions that involve finding such motifs. Two main types of motifs have been considered in the literature: matrices (of letter frequency per position in the motif) and patterns. There is no conclusive e...

  20. Central station applications planning activities and supporting studies. [application of photovoltaic technology to power generation plants

    Science.gov (United States)

    Leonard, S. L.; Siegel, B.

    1980-01-01

    The application of photovoltaic technology in central station (utility) power generation plants is considered. A program of data collection and analysis designed to provide additional information about the subset of the utility market that was identified as the initial target for photovoltaic penetration, the oil-dependent utilities (especially muncipals) of the U.S. Sunbelt, is described along with a series of interviews designed to ascertain utility industry opinions about the National Photovoltaic Program as it relates to central station applications.

  1. Evaluating functional roles of phase resetting in generation of adaptive human bipedal walking with a physiologically based model of the spinal pattern generator.

    Science.gov (United States)

    Aoi, Shinya; Ogihara, Naomichi; Funato, Tetsuro; Sugimoto, Yasuhiro; Tsuchiya, Kazuo

    2010-05-01

    The central pattern generators (CPGs) in the spinal cord strongly contribute to locomotor behavior. To achieve adaptive locomotion, locomotor rhythm generated by the CPGs is suggested to be functionally modulated by phase resetting based on sensory afferent or perturbations. Although phase resetting has been investigated during fictive locomotion in cats, its functional roles in actual locomotion have not been clarified. Recently, simulation studies have been conducted to examine the roles of phase resetting during human bipedal walking, assuming that locomotion is generated based on prescribed kinematics and feedback control. However, such kinematically based modeling cannot be used to fully elucidate the mechanisms of adaptation. In this article we proposed a more physiologically based mathematical model of the neural system for locomotion and investigated the functional roles of phase resetting. We constructed a locomotor CPG model based on a two-layered hierarchical network model of the rhythm generator (RG) and pattern formation (PF) networks. The RG model produces rhythm information using phase oscillators and regulates it by phase resetting based on foot-contact information. The PF model creates feedforward command signals based on rhythm information, which consists of the combination of five rectangular pulses based on previous analyses of muscle synergy. Simulation results showed that our model establishes adaptive walking against perturbing forces and variations in the environment, with phase resetting playing important roles in increasing the robustness of responses, suggesting that this mechanism of regulation may contribute to the generation of adaptive human bipedal locomotion.

  2. Produc—Oriented Test—Pattern Generation for Programmable Logic Arrays

    Institute of Scientific and Technical Information of China (English)

    李锦涛; 闵应骅

    1990-01-01

    A Product-oriented test-pattern generation strategy for Programmable Logic Arrays(PLAs) is presented.First the personality of products is discussed.Products are divided into several categories to speed up the test generation.This strategy aims at generating a very compact test set for crosspoint defects through the folllowing steps:1)generate special test vectors for each category of products at the beginning of test generation.Each vector is capable of detecting a great amount of crosspoint defects;2)generate test vectors for the defects which are not covered by the tests already generated.In this step,some heuristics are employed to accelerate test generation.Based on this strategy,a PLA test-pattern generation system is developed and the experimental results are analyzed.

  3. Morphodynamics and anabranching patterns generated in the Madeira River, Brazil

    Science.gov (United States)

    Latrubesse, E. M.; Bonthius, C.; Abad, J. D.; Stevaux, J.; Filizola, N.; Frias, C. E.

    2013-12-01

    The Madeira River is the largest tributary in water discharge and sediment transport of the Amazon River. At present, this river is at the center of a controversial political discussion because the Brazilian government is building two hydroelectric plants on the Bolivia-Brazil border, flooding a long reach from near Cachuela Esperanza in the tributary Beni River, close to the Brazil-Bolivia border, up to Porto Velho. We present results from three field expeditions carried out in July-August 2011, December 2012 and March 2013. The main scope of this article is to disseminate the environmental threat suffered by the Madeira from regulation/disruption, and to present preliminary results on the geomorphologic characteristics of the Madeira channel and floodplain. Using historical radar and satellite imagery, the floodplain morpho-sedimentary units and morphology of the channel were assessed and quantified. Sediment bed and bank sampling, bathymetric surveys and velocity measurements were recorded using a single beam echo sounder and an acoustic Doppler current profiler (ADCP), respectively. Velocity data were analyzed using TRDI's WinRiverII and a MATLAB-based software package Velocity Mapping Tool. We consider that the Madeira River offers some ideal conditions to provide information on critical conditions and geomorphologic thresholds in mega-rivers. The Madeira River has been classified as a simple to moderate anabranching low-sinuosity river. The Madeira flows through a relatively simple pattern, alternating straight reaches with others that exhibit an incipient tendency to anabranch. Single beam and ADCP data yields insight into the bathymetry and flow characteristics in the channel through straight, pseudo-meandering, and anabranching stretches. We studied in detail three selected three reaches zones where three primary mechanisms for anabranching were identified: a) branches upstream and downstream in box shape pseudo-meanders; b) simple branch patterns

  4. Fluid power network for centralized electricity generation in offshore wind farms

    NARCIS (Netherlands)

    Jarquin-Laguna, A.

    2014-01-01

    An innovative and completely different wind-energy conversion system is studied where a centralized electricity generation within a wind farm is proposed by means of a hydraulic network. This paper presents the dynamic interaction of two turbines when they are coupled to the same hydraulic network.

  5. EXPRESSION PATTERNS OF ESTROGEN RECEPTORS IN THE CENTRAL AUDITORY SYSTEM CHANGE IN PREPUBERTAL AND AGED MICE

    Science.gov (United States)

    Charitidi, K.; Frisina, R. D.; Vasilyeva, O. N.; Zhu, X.; Canlon, B.

    2011-01-01

    Estrogens are important in the development, maintenance and physiology of the CNS. Several studies have shown their effects on the processing of hearing in both males and females, and these effects, in part, are thought to result from regulation of the transcription of genes via their classical estrogen receptor (ER) pathway. In order to understand the spatiotemporal changes that occur with age, we have studied the expression of ERs in the central auditory pathway in prepubertal and aged CBA mice with immunohistochemistry. In prepubertal mice a clear dichotomy was noted between the expression of ERα and ERβ. ERβ-positive neurons were found in the metencephalon whereas the majority of ERα was found in mesencephalon, diencephalon or the telencephalon. In the aged animals a different pattern of ER expression was found in terms of location and overall intensity. These age-induced changes in the expression pattern were generally not uniform, suggesting that region-specific mechanisms regulate the ERs’ age-related expression. Neither the prepubertal nor the aged animals showed sex differences in any auditory structure. Our results demonstrate different age-dependent spatial and temporal changes in the pattern of expression of ERα and ERβ, suggesting that each ER type may be involved in distinct roles across the central auditory pathway in different periods of maturation. PMID:20736049

  6. PATTERN OF CUTANEOUS DISEASES IN INMATES OF CENTRAL JAIL, LUDHIANA, PUNJAB

    Directory of Open Access Journals (Sweden)

    Bimal

    2014-04-01

    Full Text Available BACKGROUND: Prisons are fertile breeding places for many skin infections and infestations; also the prevalent stressful conditions may aggravate preexisting skin problems. OBJECTIVES: To determine the pattern of cutaneous diseases in Central Jail, Ludhiana, Punjab (male prison. MATERIALS AND METHODS: The jail inmates were examined as a part of special skin camp organized in the Central Jail Ludhiana by the dermatologist after eliciting a brief history. RESULTS: Of the 157 patients examined, 70% were infectious; commonest being scabies followed by pyodermas, dermatophytosis, pityriasis versicolor, warts. Eczemas and Acne vulgaris were the most common non-infectious conditions seen. CONCLUSIONS: We recommend screening of new inmates by a dermatologist and periodic skin camps to be conducted in prisons at regular intervals.

  7. Eggs illusion: Local shape deformation generated by a grid pattern.

    Science.gov (United States)

    Qian, Kun; Mitsudo, Hiroyuki

    2016-12-01

    In this study, we report a new visual shape illusion, the eggs illusion, in which circular disks located at the midpoints between adjacent grid intersections are perceived as being deformed to ellipses. In Experiment 1, we examined the eggs illusion by using a matching method and found that grid luminance and patch size play a critical role in producing the illusory deformation. In Experiment 2, we employed several types of elliptic or circular patches to examine the conditions in which the illusory deformation was cancelled or weakened. We observed that the illusory deformation was dependent on local grid orientation. Based on these results, we found several common features between the eggs illusion and the scintillating grid illusion. This resemblance suggests a possibility that similar mechanisms underlie the two phenomena. In addition to the scintillating grid illusion, we also considered several known perceptual phenomena that might be related to the eggs illusion, i.e., the apparent size illusion, the shape-contrast effect, and the Orbison illusion. Finally, we discuss the role of orientation processing in generating the eggs illusion.

  8. Deleterious Emission Abatement through Structured Energy Use Pattern: A North Central Nigeria Perspective

    OpenAIRE

    Ajayi-Banji Ademola; Omotosho Olayinka; Amori Anthony; Alao Damilola; Igbode Imoisime; Abimbola Olufemi

    2016-01-01

    Holistic view of household energy consumption based on greenhouse gas emissions in the North Central cities of Nigeria was examined in this study. Scenarios considered were based on income level of energy users (low and high) and energy metering system (i.e. pre-paid and post-paid energy billing systems). Strong direct nexus was observed between energy use and emissions pattern. Energy utilization by post-paid category had higher weekly average value of 35.09 and 41.70 kWh as against 23.18 an...

  9. Multi-radius centralized binary pattern histogram projection for face recognition

    Institute of Scientific and Technical Information of China (English)

    Xiaofeng Fu; Wei Wei

    2009-01-01

    The existing local binary pattern (LBP) operators have several disadvantages such as rather long histograms,lower discrimination,and sensitivity to noise.Aiming at these problems,we propose the centralized binary pattern (CBP) operator.CBP operator can significantly rcduce the histograms' dimensionality,offer stronger discrimination,and decrease the white noise's influence on face images.Moreover,for increasing the recognition accuracy and speed,we use multi-radius CBP histogram as face representation and project it onto locality preserving projection (LPP) space to obtain lower dimensional features.Experiments on FERET and CAS-PEAL databases demonstrate that the proposed method is superior to other modern approaches not only in recognition accuracy but also in recognition speed.

  10. Investigation of the role of large-scale circulation patterns on Central European streamflow

    Science.gov (United States)

    Steirou, Eva; Apel, Heiko; Merz, Bruno

    2016-04-01

    Large scale oscillations-phenomena such as El Niño-Southern Oscillation (ENSO) and North Atlantic Oscillation (NAO) influence the climate and hydrological variables (temperature, precipitation, streamflow) in many areas around the globe. Here we review previous studies examining links between such phenomena and streamflow in Central Europe. The selected area under examination is the region covered by 9 countries: Germany, Poland, Switzerland, Lichtenstein, Austria, the Czech Republic, Slovakia, Hungary and Slovenia. The study takes into consideration only measured and not proxy data. Mean, low and high flows are examined separately in order to improve the understanding on the possible different influences of the climatic phenomena on different streamflow characteristics. Previous results form a consistent pattern that suggests causal relationships but only for certain indices and seasons. Most promising results concern the winter NAO index which seems to affect winter and spring streamflow in Central Europe and synoptic circulation patterns that have been linked to streamflow in the area throughout the year. Based on the findings of the review, we examine further the relations between NAO, synoptic circulation patterns and streamflow in the winter and spring season. In our analysis we examine 68 streamflow stations in Germany all covering the period 1932 to 2005. The investigation focuses on the interplay between NAO and synoptic patterns and on the effects of the climatic indices on the amplitude, spatial coherence and distributions of streamflow data. The preliminary results suggest that NAO weakly influences streamflow in both seasons and that a combined analysis with other climatic parameters may clarify possible existing links.

  11. Historical Identity Development Patterns and Contemporary Multicultural Identity in First, Second and Third Generation Counseling Students

    Science.gov (United States)

    Byrd, Nola Butler

    2009-01-01

    This study examines the historical and contemporary identity development patterns of first, second, and third generation students to determine the attributes students bring with them and how they develop through their experiences in a multicultural counselor training program. The paper examines patterns between groups, followed by a discussion of…

  12. Patterns of seabird and marine mammal carcass deposition along the central California coast, 1980-1986

    Science.gov (United States)

    Bodkin, J.L.; Jameson, R.

    1991-01-01

    At monthly intervals from February 1980 through December 1986, a 14.5-km section of central California coastline was systematically surveyed for beach-cast carcasses of marine birds and mammlas. Five hundred and fifty-four bird carcasses and 194 marine mammal carcasses were found. Common murres, western grebes, and Brandt's cormorants composed 45% of the bird total. California sea lions, sea otters, and harbor seals composed 90% of the mammal total. Several factors appeared to affect patterns of carcass deposition. The El Nino-Southern Oscillation (ENSO) of 1982-1983 was the dominate influence in terms of interannual variation in carcassdeposition. During this ENSO, 56% of the seabirds and 48% of the marine mammals washed ashore. Patterns of intra-annual variation were species specificand were related to animal migration patterns, reproduction, and seasonal changes in weather. Nearshore currents and winds influenced the general area of carcass deposition, while beach subtrate type and local patterns of san deposition influenced the location of carcass carcass deposition on a smaller spatial scale. Weekly surveys along a 1.1-km section of coastline indicated that 62% of bird carcasses and 41% of mammal carcasses remained on the beach less than 9 days. Cause of death determined for only 8% of the carcasses. Oiling was the most common indication of cause of death in birds (6%). Neonates composed 8% of all mammal carcasses.

  13. Arctic geese during brood-rearing on the central Yukon-Kuskokwim Delta: Analysis of patterns of distribution: Annual report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In July 1985 two systematic aerial surveys were flown over the coastal fringe of the central Yukon-Kuskokwim Delta, Alaska, to examine the patterns of distribution...

  14. Comparison of large central and small decentralized power generation in India

    Energy Technology Data Exchange (ETDEWEB)

    None

    1997-05-01

    This reports evaluates two options for providing reliable power to rural areas in India. The benefits and costs are compared for biomass based distributed generation (DG) systems versus a 1200-MW central grid coal-fired power plant. The biomass based DG systems are examined both as alternatives to grid extension and as supplements to central grid power. The benefits are divided into three categories: those associated with providing reliable power from any source, those associated specifically with biomass based DG technology, and benefits of a central grid coal plant. The report compares the estimated delivered costs of electricity from the DG systems to those of the central plant. The analysis includes estimates for a central grid coal plant and four potential DG system technologies: Stirling engines, direct-fired combustion turbines, fuel cells, and biomass integrated gasification combined cycles. The report also discusses issues affecting India`s rural electricity demand, including economic development, power reliability, and environmental concerns. The results of the costs of electricity comparison between the biomass DG systems and the coal-fired central grid station demonstrated that the DG technologies may be able to produce very competitively priced electricity by the start of the next century. The use of DG technology may provide a practical means of addressing many rural electricity issues that India will face in the future. Biomass DG technologies in particular offer unique advantages for the environment and for economic development that will make them especially attractive. 58 refs., 31 figs.

  15. Quantum properties of transverse pattern formation in second-harmonic generation

    DEFF Research Database (Denmark)

    Bache, Morten; Scotto, P.; Zambrini, R.;

    2002-01-01

    We investigate the spatial quantum noise properties of the one-dimensional transverse pattern formation instability in intracavity second-harmonic generation. The Q representation of a quasi-probability distribution is implemented in terms of nonlinear stochastic Langevin equations. We study...... these equations through extensive numerical simulations and analytically in the linearized limit. Our study, made below and above the threshold of pattern formation, is guided by a microscopic scheme of photon interaction underlying pattern formation in second-harmonic generation. Close to the threshold...

  16. Plate tectonics and biogeographical patterns of the Pseudophoxinus (Pisces: Cypriniformes) species complex of central Anatolia, Turkey.

    Science.gov (United States)

    Hrbek, Tomas; Stölting, Kai N; Bardakci, Fevzi; Küçük, Fahrettin; Wildekamp, Rudolf H; Meyer, Axel

    2004-07-01

    We investigated the phylogenetic relationships of Pseudophoxinus (Cyprinidae: Leuciscinae) species from central Anatolia, Turkey to test the hypothesis of geographic speciation driven by early Pliocene orogenic events. We analyzed 1141 aligned base pairs of the complete cytochrome b mitochondrial gene. Phylogenetic relationships reconstructed by maximum likelihood, Bayesian likelihood, and maximum parsimony methods are identical, and generally well supported. Species and clades are restricted to geologically well-defined units, and are deeply divergent from each other. The basal diversification of central Anatolian Pseudophoxinus is estimated to have occurred approximately 15 million years ago. Our results are in agreement with a previous study of the Anatolian fish genus Aphanius that also shows a diversification pattern driven by the Pliocene orogenic events. The distribution of clades of Aphanius and Pseudophoxinus overlap, and areas of distribution comprise the same geological units. The geological history of Anatolia is likely to have had a major impact on the diversification history of many taxa occupying central Anatolia; many of these taxa are likely to be still unrecognized as distinct.

  17. Dual CARS and SHG image acquisition scheme that combines single central fiber and multimode fiber bundle to collect and differentiate backward and forward generated photons.

    Science.gov (United States)

    Weng, Sheng; Chen, Xu; Xu, Xiaoyun; Wong, Kelvin K; Wong, Stephen T C

    2016-06-01

    In coherent anti-Stokes Raman scattering (CARS) and second harmonic generation (SHG) imaging, backward and forward generated photons exhibit different image patterns and thus capture salient intrinsic information of tissues from different perspectives. However, they are often mixed in collection using traditional image acquisition methods and thus are hard to interpret. We developed a multimodal scheme using a single central fiber and multimode fiber bundle to simultaneously collect and differentiate images formed by these two types of photons and evaluated the scheme in an endomicroscopy prototype. The ratio of these photons collected was calculated for the characterization of tissue regions with strong or weak epi-photon generation while different image patterns of these photons at different tissue depths were revealed. This scheme provides a new approach to extract and integrate information captured by backward and forward generated photons in dual CARS/SHG imaging synergistically for biomedical applications.

  18. Automatic test pattern generation for logic circuits using the Boolean tree

    Energy Technology Data Exchange (ETDEWEB)

    Jeong Taegwon.

    1991-01-01

    The goal of this study was to develop an algorithm that can generate test patterns for combinational circuits and sequential logic circuits automatically. The new proposed algorithm generates a test pattern by using a special tree called a modified Boolean tree. In this algorithm, the construction of a modified Boolean tree is the most time-consuming step. Following the construction of a modified Boolean tree, a test pattern can be found by simply assigning a logic value 1 for even primary inputs and a logic value 0 for odd primary inputs of the constructed modified Boolean tree. The algorithm is applied to several benchmark circuits. The results showed the following: (1) for combinational circuits, the algorithm can generate test patterns 10-15% faster than the FAN algorithm, which is known as one of the most efficient algorithms to-date; (2) for sequential circuits, the algorithm shows more fault coverage than the nine valued algorithm.

  19. Generation of a central nervous system catheter-associated infection in mice with Staphylococcus epidermidis.

    Science.gov (United States)

    Snowden, Jessica N

    2014-01-01

    Animal models are valuable tools for investigating the in vivo pathogenesis of Staphylococcus epidermidis infections. Here, we present the procedure for generating a central nervous system catheter-associated infection in a mouse, to model the central nervous system shunt infections that frequently complicate the treatment of hydrocephalus in humans. This model uses stereotactic guidance to place silicone catheters, pre-coated with S. epidermidis, into the lateral ventricles of mice. This results in a catheter-associated infection in the brain, with concomitant illness and inflammation. This animal model is a valuable tool for evaluating the pathogenesis of bacterial infection in the central nervous system, the immune response to these infections and potential treatment options.

  20. Automatic Generation of English-Japanese Translation Pattern Utilizing Genetic Programming Technique

    Science.gov (United States)

    Matsumura, Koki; Tamekuni, Yuji; Kimura, Shuhei

    There are a lot of constructional differences in an English-Japanese phrase template, and that often makes the act of translation difficult. Moreover, there exist various and tremendous phrase templates and sentence to be refered to. It is not easy to prepare the corpus that covers the all. Therefore, it is very significant to generate the translation pattern of the sentence pattern automatically from a viewpoint of the translation success rate and the capacity of the pattern dictionary. Then, for the purpose of realizing the automatic generation of the translation pattern, this paper proposed the new method for the generation of the translation pattern by using the genetic programming technique (GP). The technique tries to generate the translation pattern of various sentences which are not registered in the phrase template dictionary automatically by giving the genetic operation to the parsing tree of a basic pattern. The tree consists of the pair of the English-Japanese sentence generated as the first stage population. The analysis tree data base with 50,100,150,200 pairs was prepared as the first stage population. And this system was applied and executed for an English input of 1,555 sentences. As a result, the analysis tree increases from 200 to 517, and the accuracy rate of the translation pattern has improved from 42.57% to 70.10%. And, 86.71% of the generated translations was successfully done, whose meanings are enough acceptable and understandable. It seemed that this proposal technique became a clue to raise the translation success rate, and to find the possibility of the reduction of the analysis tree data base.

  1. Electric generator overhaul of the Ing. Carlos Ramirez Ulloa hydroelectric. Central project conclusions; Rehabilitacion de los generadores de la central hidroelectrica Ing. Carlos Ramirez Ulloa. Conclusiones del proyecto

    Energy Technology Data Exchange (ETDEWEB)

    Campuzano Martinez, Ignacio Roberto; Gonzalez Vazquez, Alejandro Esteban; Robles Pimentel, Edgar Guillermo; Esparza Saucedo, Marcos; Garcia Martinez, Javier; Sanchez Flores, Ernesto; Martinez Romero, Jose Luis [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1998-12-31

    The Hydroelectric Ing. Carlos Ramirez Ulloa Power Central has three 200 MW electric generators. The Central initiated its commercial operation in 1985. The electric generators had design problems that were properly corrected in an overhaul program that was initiated in 1996, with Unit 2 electric generator and completed in 1998 with Unit 1 electric generator. This paper presents the relevant aspects of the experience accumulated in the project. [Espanol] La central hidroelectrica Ing. Carlos Ramirez Ulloa cuenta con tres generadores de 200 MW cada uno. La central inicio su operacion comercial en 1985. Los generadores tenian problemas de diseno que fueron debidamente corregidos en un programa de rehabilitacion que inicio en 1996, con el generador de la unidad 2, y culmino en 1998 con el generador de la unidad 1. En este articulo se presentan los aspectos relevantes de la experiencia acumulada en el proyecto.

  2. Hybrid centralized-distributed power conditioning system for thermoelectric generator with high energy efficiency

    DEFF Research Database (Denmark)

    Wu, Hongfei; Sun, Kai; Chen, Min;

    2013-01-01

    The unbalanced temperature distribution influences the power output of thermoelectric generator (TEG) system, which leads to mismatch power among TEG modules. This mismatch power degrades the energy efficiency of TEG systems based on the series-connected TEG modules. A hybrid centralized-distribu......The unbalanced temperature distribution influences the power output of thermoelectric generator (TEG) system, which leads to mismatch power among TEG modules. This mismatch power degrades the energy efficiency of TEG systems based on the series-connected TEG modules. A hybrid centralized...... the proposed system, which benefits for implementing high MPPT efficiency and high conversion efficiency simultaneously. A hybrid MPPT control strategy is proposed for this HCD power conditioning system. The characteristics, circuit implementation and operation principles of the proposed system are presented...

  3. Generating power stations and optimization energetic of processes; Centrales generadoras y optimacion energetica de procesos

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez Ramirez, Ranulfo; Fernandez Montiel, Manuel Francisco [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    1999-07-01

    Some recent experiences of the Management of Thermal Processes of the Instituto de Investigaciones Electricas (IIE) related to the works on generating power stations of electricity, plants of cogeneration and energy saving are presented. [Spanish] Se presentan algunas experiencias recientes de la Gerencia de Procesos Termicos del Instituto de Investigaciones Electricas (IIE) relacionadas con los trabajos sobre centrales generadoras de electricidad, plantas de cogeneracion y ahorro de energia.

  4. The Lycaenid Central Symmetry System: Color Pattern Analysis of the Pale Grass Blue Butterfly Zizeeria maha.

    Science.gov (United States)

    Iwata, Masaki; Taira, Wataru; Hiyama, Atsuki; Otaki, Joji M

    2015-06-01

    The nymphalid groundplan has been proposed to explain diverse butterfly wing color patterns. In this model, each symmetry system is composed of a core element and a pair of paracore elements. The development of this elemental configuration has been explained by the induction model for positional information. However, the diversity of color patterns in other butterfly families in relation to the nymphalid groundplan has not been thoroughly examined. Here, we examined aberrant color pattern phenotypes of a lycaenid butterfly, Zizeeria maha, from mutagenesis and plasticity studies as well as from field surveys. In several mutants, the third and fourth spot arrays were coordinately positioned much closer to the discal spot in comparison to the normal phenotype. In temperature-shock types, the third and fourth array spots were elongated inwardly or outwardly from their normal positions. In field-caught spontaneous mutants, small black spots were located adjacent to normal black spots. Analysis of these aberrant phenotypes indicated that the spots belonging to the third and fourth arrays are synchronously changeable in position and shape around the discal spot. Thus, these arrays constitute paracore elements of the central symmetry system of the lycaenid butterflies, and the discal spot comprises the core element. These aberrant phenotypes can be explained by the black-inducing signals that propagate from the prospective discal spot, as predicted by the induction model. These results suggest the existence of long-range developmental signals that cover a large area of a wing not only in nymphalid butterflies, but also in lycaenid butterflies.

  5. On-Shore Central Hydraulic Power Generation for Wind and Tidal Energy

    Science.gov (United States)

    Jones, Jack A.; Bruce, Allan; Lim, Steven; Murray, Luke; Armstrong, Richard; Kimbrall, Richard; Cook-Chenault, Kimberly; DeGennaro, Sean

    2012-01-01

    Tidal energy, offshore wind energy, and onshore wind energy can be converted to electricity at a central ground location by means of converting their respective energies into high-pressure hydraulic flows that are transmitted to a system of generators by high-pressure pipelines. The high-pressure flows are then efficiently converted to electricity by a central power plant, and the low-pressure outlet flow is returned. The Department of Energy (DOE) is presently supporting a project led by Sunlight Photonics to demonstrate a 15 kW tidal hydraulic power generation system in the laboratory and possibly later submerged in the ocean. All gears and submerged electronics are completely eliminated. A second portion of this DOE project involves sizing and costing a 15 MW tidal energy system for a commercial tidal energy plant. For this task, Atlantis Resources Corporation s 18-m diameter demonstrated tidal blades are rated to operate in a nominal 2.6 m/sec tidal flow to produce approximately one MW per set of tidal blades. Fifteen units would be submerged in a deep tidal area, such as in Maine s Western Passage. All would be connected to a high-pressure (20 MPa, 2900 psi) line that is 35 cm ID. The high-pressure HEPG fluid flow is transported 500-m to on-shore hydraulic generators. HEPG is an environmentally-friendly, biodegradable, watermiscible fluid. Hydraulic adaptations to ORPC s cross-flow turbines are also discussed. For 15 MW of wind energy that is onshore or offshore, a gearless, high efficiency, radial piston pump can replace each set of top-mounted gear-generators. The fluid is then pumped to a central, easily serviceable generator location. Total hydraulic/electrical efficiency is 0.81 at full rated wind or tidal velocities and increases to 0.86 at 1/3 rated velocities.

  6. Auto-Pattern Programmable Kernel Filter (Auto-PPKF for Suppression of Bot Generated Traffic

    Directory of Open Access Journals (Sweden)

    Kritika Govind

    2013-11-01

    Full Text Available Bots usually vary from their other malicious counter parts by periodically reporting to the botmaster through regular exchange of messages. Our experiments on bot attack generation showed a continuous exchange of packets with similar content between the botmaster and the zombie machine at various time intervals. Though there were also genuine packets with similar content being sent out of the victim machine challenge was to differentiate between the two and pass only the genuine ones. In this paper, an algorithm namely Auto-Pattern Programmable Kernel Filter (Auto-PPKF, for automatic detection of patterns from packet payload for filtering out malicious packets generated by bots is proposed. The significant feature of our proposed Auto-PPKF algorithm is that, the malicious pattern is deduced at kernel level on the fly from packet payload. Traditional algorithms such as Boyer Moore, Knuth Morris Patt, and Naive Pattern search algorithms require the pattern to be identified available a priori. Currently, Longest Common Subsequence (LCS algorithm stands as the most preferred algorithm for pattern matching. But the disadvantage is that common sequences can also exist in many genuine packets. Hence, the challenge lies in automatic detection of malicious patterns and filtering of the packets having such malicious patterns. This would not only put off the communication between the Botmaster and Zombie machine, but will also thus prevent user information from being sent to the botmaster.

  7. A study of air flow patterns affecting pollutant concentrations in the Central Region of Mexico

    Science.gov (United States)

    Jazcilevich, Aron D.; García, Agustín. R.; Ruíz-Suárez, L. Gerardo

    Using a prognostic air quality model that includes actual emissions, air pollution regimes over the central region of Mexico are simulated. It is shown that due to the complex orography, vertical circular patterns develop over the metropolitan area of Mexico City. In this way reactive and non-reactive pollutants can travel near the surface, be transported vertically and land in an area opposite to its initial route due to convective downward currents. This changes the surface pollutant concentrations on the landing area. Also, it is shown that air pollution is transported near the surface from the metropolitan area of Mexico City through Chalco in the South-east corner of the Mexico Valley, to the Valley of Cuautla affecting this area.

  8. High-fidelity spherical cholesteric liquid crystal Bragg reflectors generating unclonable patterns for secure authentication

    Science.gov (United States)

    Geng, Yong; Noh, Junghyun; Drevensek-Olenik, Irena; Rupp, Romano; Lenzini, Gabriele; Lagerwall, Jan P. F.

    2016-05-01

    Monodisperse cholesteric liquid crystal microspheres exhibit spherically symmetric Bragg reflection, generating, via photonic cross communication, dynamically tuneable multi-coloured patterns. These patterns, uniquely defined by the particular sphere arrangement, could render cholesteric microspheres very useful in countless security applications, as tags to identify and authenticate their carriers, mainly physical objects or persons. However, the optical quality of the cholesteric droplets studied so far is unsatisfactory, especially after polymerisation, a step required for obtaining durable samples that can be used for object identification. We show that a transition from droplets to shells solves all key problems, giving rise to sharp patterns and excellent optical quality even after polymerisation, the polymerised shells sustaining considerable mechanical deformation. Moreover, we demonstrate that, counter to prior expectation, cross communication takes place even between non-identical shells. This opens additional communication channels that add significantly to the complexity and unique character of the generated patterns.

  9. Design of Low Power Test Pattern Generator using Low Transition LFSR for high Fault Coverage Analysis

    Directory of Open Access Journals (Sweden)

    Chethan J

    2013-08-01

    Full Text Available A low power Test Pattern Generator (TPG designed by modifying Linear Feedback Shift Register is proposed to produce low power test vectors that are deployed on Circuit under Test (CUT to slenderize thedynamic power consumption by CUT. The technique involved in generating low power test patterns is performed by increasing the correlativity between the successive vectors; the ambiguity in increasing the similarity between consecutive vectors is resolved by reducing the number of bit flips between successive test patterns. Upon deploying the low power test patterns at the inputs of CUT, slenderizes the switching activities inside CUT that in turn reduces its dynamic power consumption. The resulted low power test vectors are deployed on CUT to obtain fault coverage. The experimental results demonstrate significant power reduction by low power TPG than compared to standard LFSR.

  10. Influence of regional precipitation patterns on stable isotopes in ice cores from the central Himalayas

    Directory of Open Access Journals (Sweden)

    H. Pang

    2013-05-01

    Full Text Available Several ice cores have been recovered from the Dasuopu Glacier and the East Rongbuk (ER Glacier in the central Himalayas since the 1990s. Although the distance between the ER and the Dasuopu ice core drilling sites is only ∼125 km, the stable isotopic record (δ18O or δD of the ER core is interpreted as a precipitation proxy while the Dasuopu core as a temperature proxy. Thus, the climatological significance of the stable isotopic records of these Himalayan ice cores remains a subject of debate. Based on analysis of regional precipitation patterns over the region, we find that the different interpretations of the Dasuopu and Everest isotopic records may not be contradictive. The north–south and west–east seesaws of the Indian Summer Monsoon (ISM precipitation are primarily responsible for precipitation falling at the ER site, which results in a negative correlation between the ER δ18O or δD record and precipitation amount along the southern slope of the central Himalayas, corresponding to the "amount effect". In addition to the ISM precipitation, non-summer monsoonal precipitation associated with winter westerlies also significantly contributes to precipitation falling at the Dasuopu site, which may cause a positive correlation between the Dasuopu stable isotopic record and temperature, in response to the "temperature effect". Our results have important implications for interpreting the stable isotopic ice core records recovered from different climatological regimes of the Himalayas.

  11. Computational and Experimental Evaluation of a Complex Inlet Swirl Pattern Generation System (POSTPRINT)

    Science.gov (United States)

    2016-08-01

    pattern generation system composed of continuous patterns of turning vanes. Successful demonstration of the evaluation methods required acceptable ...demonstration of the evaluation methods required acceptable comparison of the PIV and CFD to an independent 5-hole probe measurement performed at the...capabilities to produce user-specified, complex inlet velocity fields and flow angularity.5 Resultantly, StreamVanes offer a rapid and cost effective

  12. Spatial pattern analysis for quantification of landscape structure of Tadoba-Andhari Tiger Reserve, Central India

    Institute of Scientific and Technical Information of China (English)

    Ambica Paliwal; Vinod Bihari Mathur

    2014-01-01

    Landscape structure is often regarded as an important factor that governs the distribution and abundance of species. Therefore it is critical to understand the landscapes and their dynamics. Patterns of landscape elements strongly influence the ecological characteristics. This study was designed to document and map the current status of the tropi-cal dry deciduous forest of the Tadoba-Andhari Tiger Reserve (TATR), Central India, (using IRS P6 LISS IV data) and to describe its landscape structure at three levels of organization viz. landscape, class, and patch. The study area was classified into 10 land cover classes that include 6 vegetation classes. The landscape structure was analyzed using FRAG-STATS using 12 set of indices. The TATR landscapes have a total of 2,307 patches with a mean patch size of 25.67 ha and patch density of 1.7 patches per km². Amongst all land cover classes, mixed bamboo forest is dominant-it occupied maximum area (77.99%)-while riparian forest is least represented (0.32%). Mixed forest has maximum number of patches among all vegetation classes. Results have shown that despite being dominant in the area, mixed bamboo forest has low patch density (0.25/100 ha). Dominance of mixed bamboo forest is attributed to large patch sizes and not to the number of patches. This study has focussed on the approach of integrating satellite forest classification and forest inven-tory data for studying forest landscape patterns.

  13. Vegetation recovery patterns assessment at landslides caused by catastrophic earthquake: a case study in central Taiwan.

    Science.gov (United States)

    Chou, Wen-Chieh; Lin, Wen-Tzu; Lin, Chao-Yuan

    2009-05-01

    The catastrophic earthquake, 7.3 on the Richter scale, occurred on September 21, 1999 in Central Taiwan. Much of standing vegetation on slopes was eliminated and massive, scattered landslides were induced at the Jou-Jou Mountain area of the Wu-Chi basin in Nantou County. We evaluated three methods for assessing landslide hazard and vegetation recovery conditions. (1) Self-organizing map (SOM) neural network coupled with fuzzy technique was used to quickly extract the landslide. (2) The NDVI-based vegetation recovery index derived from multi-temporal SPOT satellite images was used to evaluate vegetation recovery rate in the denudation sites. (3) The spatial distribution index (SDI) based on land-cover topographic location was employed to analyze vegetation recovery patterns, including the invading, surviving and mixed patterns at the Jou-Jou Mountain area. On September 27, 1999, there were 849.20 ha of landslide area extracted using the self-organizing map and fuzzy technique combined model. After six years of natural vegetation succession, the landslide has gradually restored, and vegetation recovery rate reached up to 86%. On-site observation shows that many native pioneer plants have invaded onto the denudation sites even if disturbed by several typhoons. Two native surviving plants, Arundo formosana Hack and Pinus taiwanensis Hayata, play a vital role in natural vegetation succession in this area, especially for the sites on ridgeline and steep slopes.

  14. Novel Unique Technique for Generating Ticket Identifier Using Image Texture Patterns

    Directory of Open Access Journals (Sweden)

    Mrs. Jayashree Katti

    2014-05-01

    Full Text Available A paperless ticketing system with an application through which user can purchase a mobile ticket. Once the purchasing information is provided, the mobile ticket can be sent to the respective users mobile. A new method is introduced to generate tickets in which texture pattern is generated for digest provided by md5. The ticket is sent in the format of image consisting of texture patterns. Ticket can be verified by ticket checker using an application developed to verify genuine ticket. This system will be a revolution in the m-commerce world.

  15. Patterns in volatile organic compound emissions along a savanna-rainforest gradient in central Africa

    Science.gov (United States)

    Klinger, L. F.; Greenburg, J.; Guenther, A.; Tyndall, G.; Zimmerman, P.; M'bangui, M.; Moutsamboté, J.-M.; Kenfack, D.

    1998-01-01

    In temperate regions the chemistry of the lower troposphere is known to be significantly affected by biogenic volatile organic compounds (VOCs) emitted by plants. The chemistry of the lower troposphere over the tropics, however, is poorly understood, in part because of the considerable uncertainties in VOC emissions from tropical ecosystems. Present global VOC models predict that base emissions of isoprene from tropical rainforests are considerably higher than from savannas. These global models of VOC emissions which rely mainly on species inventories are useful, but significant improvement might be made with more ecologically based models of VOC emissions by plants. Ecosystems along a successional transect from woodland savanna to primary rainforest in central Africa were characterized for species composition and vegetation abundance using ground surveys and remotely sensed data. A total of 336 species (mostly trees) at 13 sites were recorded, and 208 of these were measured for VOC emissions at near-optimal light and temperature conditions using a leaf cuvette and hand-held photoionization detector (PID). A subset of 59 species was also sampled using conventional VOC emission techniques in order to validate the PID technique. Results of ecological and VOC emission surveys indicate both phylogenetic and successional patterns along the savanna-rainforest transect. Genera and families of trees which tend to emit isoprene include Lophira, Irvingia, Albizia, Artocarpus, Ficus, Pterocarpus, Caesalpiniaceae, Arecaceae, and Moraceae. Other taxa tend to contain stored VOCs (Annonaceae and Asteraceae). Successional patterns suggest that isoprene emissions are highest in the relatively early successional Isoberlinia forest communities and progressively decrease in the later successional secondary and primary rainforest communities. Stored VOCs appear to increase along the savanna-rainforest succession, but these data are more tentative. These findings are consistent with

  16. Impact of resistant starch on body fat patterning and central appetite regulation.

    Directory of Open Access Journals (Sweden)

    Po-Wah So

    Full Text Available BACKGROUND: Adipose tissue patterning has a major influence on the risk of developing chronic disease. Environmental influences on both body fat patterning and appetite regulation are not fully understood. This study was performed to investigate the impact of resistant starch (RS on adipose tissue deposition and central regulation of appetite in mice. METHODOLOGY AND PRINCIPLE FINDINGS: Forty mice were randomised to a diet supplemented with either the high resistant starch (HRS, or the readily digestible starch (LRS. Using (1H magnetic resonance (MR methods, whole body adiposity, intrahepatocellular lipids (IHCL and intramyocellular lipids (IMCL were measured. Manganese-enhanced MRI (MEMRI was used to investigate neuronal activity in hypothalamic regions involved in appetite control when fed ad libitum. At the end of the interventional period, adipocytes were isolated from epididymal adipose tissue and fasting plasma collected for hormonal and adipokine measurement. Mice on the HRS and LRS diet had similar body weights although total body adiposity, subcutaneous and visceral fat, IHCL, plasma leptin, plasma adiponectin plasma insulin/glucose ratios was significantly greater in the latter group. Adipocytes isolated from the LRS group were significantly larger and had lower insulin-stimulated glucose uptake. MEMRI data obtained from the ventromedial and paraventricular hypothalamic nuclei suggests a satiating effect of the HRS diet despite a lower energy intake. CONCLUSION AND SIGNIFICANCE: Dietary RS significantly impacts on adipose tissue patterning, adipocyte morphology and metabolism, glucose and insulin metabolism, as well as affecting appetite regulation, supported by changes in neuronal activity in hypothalamic appetite regulation centres which are suggestive of satiation.

  17. Second-Generation central venous catheter in the prevention of bloodstream infection: a systematic review 1

    Science.gov (United States)

    Stocco, Janislei Gislei Dorociaki; Hoers, Hellen; Pott, Franciele Soares; Crozeta, Karla; Barbosa, Dulce Aparecida; Meier, Marineli Joaquim

    2016-01-01

    Abstract Objective: to evaluate the effectiveness and safety in the use of second-generation central venous catheters impregnated in clorhexidine and silver sulfadiazine when compared with other catheters, being them impregnated or not, in order to prevent the bloodstream infection prevention. Method: systematic review with meta-analysis. Databases searched: MEDLINE, EMBASE, CINAHL, LILACS/SciELO, Cochrane CENTRAL; search in Congress Proceedings and records from Clinical Trials. Results: 1.235 studies were identified, 97 were pre-selected and 4 were included. In catheter-related bloodstream infection, there was no statistical significance between second-generation impregnated catheter compared with the non-impregnated ones, absolute relative risk 1,5% confidence interval 95% (3%-1%), relative risk 0,68 (confidence interval 95%, 0,40-1,15) and number needed to treat 66. In the sensitivity analysis, there was less bloodstream infection in impregnated catheters (relative risk 0,50, confidence interval 95%, 0,26-0,96). Lower colonization, absolute relative risk 9,6% (confidence interval 95%, 10% to 4%), relative risk 0,51 (confidence interval 95% from 0,38-0,85) and number needed to treat 5. Conclusion: the use of second-generation catheters was effective in reducing the catheter colonization and infection when a sensitivity analysis is performed. Future clinical trials are suggested to evaluate sepsis rates, mortality and adverse effects. PMID:27508901

  18. Deposition, characterization, patterning and mechanistic study of inorganic resists for next-generation nanolithography

    Science.gov (United States)

    Luo, Feixiang

    The semiconductor industry has witnessed a continuous decrease in the size of logic, memory and other computer chip components since its birth over half a century ago. The shrinking (scaling) of components has to a large extent been enabled by the development of micro- and now nano-lithographic techniques. This thesis focuses on one central component of lithography, the resist, which is essentially a thin film that when appropriately exposed enables a pattern to be printed onto a surface. Smaller features require an ever more precisely focused photon, electron or ion beam with which to expose the resist. The likely next generation source of radiation that will enable sub-20nm features to be written will employ extreme ultraviolet radiation (EUV), 92eV (13.5nm). The work discussed here involves a novel class of inorganic resists (including a solution processed Hf-based resist called HafSOx), as the organic resists that have dominated the microlithography industry for the past few decades have approached fundamental scaling limits. In order to maintain the high throughput required by high volume semiconductor manufacturing, metal oxide resists have been proposed and developed to meet the resolution and sensitivity in EUV lithography. One can think of our resists as the nano-lithographic analog to the silver halide film that dominated the photographic print industry for a century. In this thesis, we mainly describe our work on HafSOx, a "first generation" metal oxide EUV resist system. HafSOx thin films can be deposited by spin-coating a mixed solution of HfOCl2, H2O 2, and H2SO4. Various materials characterization techniques have been employed to achieve a comprehensive understanding of film composition and structure at both surface and bulk level, as well as a mechanistic understanding of the film radiation chemistry. Taking advantage of the high energy x-rays used in the XPS experiment, we developed an experiment to dynamically monitor the photochemistry within the

  19. Staff Draft Report. Comparative Cost of California Central Station Electricity Generation Technologies.

    Energy Technology Data Exchange (ETDEWEB)

    Badr, Magdy; Benjamin, Richard

    2003-02-11

    This Energy Commission staff draft report presents preliminary levelized cost estimates for several generic central-station electricity generation technologies. California has traditionally adopted energy policies that balance the goals of supporting economic development, improving environmental quality and promoting resource diversity. In order to be effective, such policies must be based on comprehensive and timely gathering of information. With this goal in mind, the purpose of the report is to provide comparative levelized cost estimates for a set of renewable (e.g., solar) and nonrenewable (e.g., natural gas-fired) central-station electricity generation resources, based on each technology's operation and capital cost. Decision-makers and others can use this information to compare the generic cost to build specific technology. These costs are not site specific. If a developer builds a specific power plant at a specific location, the cost of siting that plant at that specific location must be considered. The Energy Commission staff also identifies the type of fuel used by each technology and a description of the manner in which the technology operates in the generation system. The target audiences of this report are both policy-makers and anyone wishing to understand some of the fundamental attributes that are generally considered when evaluating the cost of building and operating different electricity generation technology resources. These costs do not reflect the total cost to consumers of adding these technologies to a resources portfolio. These technology characterizations do not capture all of the system, environmental or other relevant attributes that would typically be needed by a portfolio manager to conduct a comprehensive ''comparative value analysis''. A portfolio analysis will vary depending on the particular criteria and measurement goals of each study. For example, some form of firm capacity is typically needed with wind

  20. The Development of Group Interaction Patterns: How Groups become Adaptive, Generative, and Transformative Learners

    Science.gov (United States)

    London, Manuel; Sessa, Valerie I.

    2007-01-01

    This article integrates the literature on group interaction process analysis and group learning, providing a framework for understanding how patterns of interaction develop. The model proposes how adaptive, generative, and transformative learning processes evolve and vary in their functionality. Environmental triggers for learning, the group's…

  1. The activation pattern of macrophages in giant cell (temporal) arteritis and primary angiitis of the central nervous system.

    Science.gov (United States)

    Mihm, Bernhard; Bergmann, Markus; Brück, Wolfgang; Probst-Cousin, Stefan

    2014-06-01

    To determine if the pattern of macrophage activation reflects differences in the pathogenesis and clinical presentation of giant cell arteritis and primary angiitis of the central nervous system, specimens of 10 patients with giant cell arteritis and five with primary angiitis of the central nervous system were immunohistochemically studied and the expression of the macrophage activation markers 27E10, MRP14, MRP8 and 25F9 was determined in the vasculitic infiltrates. Thus, a partly different expression pattern of macrophage activation markers in giant cell arteritis and primary angiitis of the central nervous system was observed. The group comparison revealed that giant cell arteritis cases had significantly higher numbers of acute activated MRP14-positive macrophages, whereas primary angiitis of the central nervous system is characterized by a tendency toward more MRP8-positive intermediate/late activated macrophages. Furthermore, in giant cell arteritis comparably fewer CD8-positive lymphocytes were observed. These observations suggest, that despite their histopathological similarities, giant cell arteritis and primary angiitis of the central nervous system appear to represent either distinct entities within the spectrum of granulomatous vasculitides or different stages of similar disease processes. Their discrete clinical presentation is reflected by different activation patterns of macrophages, which may characterize giant cell arteritis as a more acute process and primary angiitis of the central nervous system as a more advanced inflammatory process.

  2. Climatic patterns and extreme rainfalls on coastal areas in Central Italy

    Science.gov (United States)

    Bramati, M. C.; Tarragoni, C.

    2012-04-01

    In this paper we focus on the extreme values analysis to estimate the rainfall return levels for some Adriatic and Tyrrhenian coastal areas in central Italy. Two approaches are mainly considered: the first one is based on the maximum annual daily rainfall series (1-day, 2-day and 3-day) for which suitable probability distributions are fitted, whereas the second one is based on the series of peaks over annual thresholds (POT) for which the best fitting Generalized Pareto distribution is identified. Spectral analysis and appropriate tests for stationarity and homogeneity are run in order to verify the hypothesis under which the analysis performed is valid. From the density plots and the parameter estimates of the fitted distributions to the various annual maximum rainfall series we can conclude that there is a different pattern in the occurrence of extreme events for the western coast with respect to the eastern coast. Specifically, on the Tyrrhenian side extreme rainfalls are more likely to happen in correspondence of longer time spans (i.e. 3-day series) as the effect of cumulated stable rainfalls over time. On the opposite, for the Adriatic coast extremes are more frequent in shorter time spans (1-day). A vector autoregressive model is then estimated and through a causal ordering the identifying restrictions are set. The impulse response analysis shows a lag in the transmission of rainfall shocks of the central Adriatic coast to the Tyrrhenian one. This paper is prepared as a background paper to the SECOA N1.2 Report: Assessment of frequency-magnitude of extreme rainfall events and flooding. Project SECOA (Solutions for Environmental contrast in Coastal Areas) is funded by the EU Commission within the 7th Framework Programme (2007-2013).

  3. Post-release survival and movements patterns of roosterfish (Nematistius pectoralis off the Central American coastline

    Directory of Open Access Journals (Sweden)

    Chugey A Sepulveda

    2015-03-01

    Full Text Available Acoustic telemetry was used to assess immediate post-release survival and track the short-term movement patterns of roosterfish Nematistius pectoralis between 2008 and 2010. Seven roosterfish (85 to 146 cm fork length, FL were continuously tracked along the Central American coastline for periods of up to 28 h following capture on recreational fishing tackle. All seven roosterfish were initially captured and spent the duration of the track period proximal to the coastline in waters <100 m of depth. From depth records and horizontal movements, it was determined that all seven roosterfish survived the acute effects of capture. The greatest depth achieved by any of the tracked individuals was 62 m and collectively roosterfish spent over 90% of the track records between the surface and 12 m. For all tracks, fish size showed no effect on maximum or average dive depth and the average day (7 ± 2 m and night (6 ± 2 m depths were similar among individuals. Mean water temperature for all tracks was 28 ± 1°C, with the lowest temperature experienced at depth being 23°C. Total horizontal movements from the roosterfish in this study ranged from 14.7 to 42.2 km and averaged 1.5 ± 0.4 km h-1. Data on movements in relation to bathymetry, prey presence and habitat structure are discussed. Collectively, these data provide insight into the immediate post-release disposition and short-term movements of this poorly studied species along the coast of Central America.

  4. Patterns of mercury dispersion from local and regional emission sources, rural Central Wisconsin, USA

    Directory of Open Access Journals (Sweden)

    A. Kolker

    2010-01-01

    Full Text Available Simultaneous real-time changes in mercury (Hg speciation – reactive gaseous Hg (RGM, elemental Hg (Hg°, and fine particulate Hg (Hg-PM2.5, were determined from June to November 2007, in ambient air at three locations in rural Central Wisconsin. Known Hg emission sources within the airshed of the monitoring sites include: 1 a 1114 megawatt (MW coal-fired electric utility generating station; 2 a Hg-bed chlor-alkali plant; and 3 a smaller (465 MW coal-burning electric utility. Monitoring sites, showing sporadic elevation of RGM, Hg° and Hg-PM2.5, were positioned at distances of 25, 50 and 100 km northward of the larger electric utility. A series of RGM events were recorded at each site. The largest, on 23 September, occurred under prevailing southerly winds, with a maximum RGM value (56.8 pg m−3 measured at the 100 km site, and corresponding elevated SO2 (10.41 ppbv; measured at 50 km site. The finding that RGM, Hg°, and Hg-PM2.5 are not always highest at the 25 km site, closest to the large generating station, contradicts the idea that RGM decreases with distance from a large point source. This may be explained if: 1 the 100 km site was influenced by emissions from the chlor-alkali facility or by RGM from regional urban sources; 2 the emission stack height of the larger power plant promoted plume transport at an elevation where the Hg is carried over the closest site; or 3 RGM was being generated in the plume through oxidation of Hg°. Operational changes at each emitter since 2007 should reduce their Hg output, potentially allowing quantification of the environmental benefit in future studies.

  5. Semi-arid Vegetation Pattern, Stability and Suitability to Suppress Sand Movement in Central Sudan

    Directory of Open Access Journals (Sweden)

    N.K.N. Al-Amin

    2011-01-01

    Full Text Available Moving sand that threatens Gezira scheme is the dominant land degradation feature in central Sudan and the front line defence is the sparse scattered natural vegetation of the area. The study aimed to assess the role of this vegetation to suppress drifting sand and to monitor their ability to face the impact of climate change and human activity (deforestation. The dimensions of the sand captured by single tree of dominant species, Acacia tortilis, Leptadenia pyrotechnica, Prosopis juliflora and Panicum turgidum were measured and the volumes were calculated. To picture the drought pattern 5-year running means of annual rainfalls (1941-2007 of the study area were calculated and compared with long-term mean. Deforestation was indicated by local community wood consumption in relation to the average woody biomass (in good condition. The results show that scattered trees of the right densities had potentiality to settle drifting sand, but they were subjected to 20 years dry seasons followed by only 4 wet years and now are subjected to a new era of dry spell. This condition is not in favour of the semi-arid vegetation pattern sustainability and a suitable measure to enhance natural regeneration is needed. In addition, the community's wood demand was higher than the resource, where a person would destroy 0.5 ha/year compared to 0.9 ha/year per person available reveals the magnitude of deforestation. Encouragement of farmers to use alternative energy sources and functional application of laws and regulations to protect the existing vegetation rem ain crucial.

  6. Systematic expression analysis of Hox genes at adulthood reveals novel patterns in the central nervous system.

    Science.gov (United States)

    Hutlet, Bertrand; Theys, Nicolas; Coste, Cécile; Ahn, Marie-Thérèse; Doshishti-Agolli, Konstantin; Lizen, Benoît; Gofflot, Françoise

    2016-04-01

    Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated. We provide here the first detailed quantitative and neuroanatomical characterization of the expression of the 39 Hox genes in the adult mouse brain. Using RT-qPCR we determined the expression of 24 Hox genes mainly in the brainstem of the adult brain, with low expression of a few genes in the cerebellum and the forebrain. Using in situ hybridization (ISH) we have demonstrated that expression of Hox genes is maintained in territories derived from the early segmental Hox expression domains in the hindbrain. Indeed, we show that expression of genes belonging to paralogy groups PG2-8 is maintained in the hindbrain derivatives at adulthood. The spatial colinearity, which characterizes the early embryonic expression of Hox genes, is still observed in sequential antero-posterior boundaries of expression. Moreover, the main mossy and climbing fibres precerebellar nuclei express PG2-8 Hox genes according to their migration origins. Second, ISH confirms the presence of Hox gene transcripts in territories where they are not detected during development, suggesting neo-expression in these territories in adulthood. Within the forebrain, we have mapped Hoxb1, Hoxb3, Hoxb4, Hoxd3 and Hoxa5 expression in restricted areas of the sensory cerebral cortices as well as in specific thalamic relay nuclei. Our data thus suggest a requirement of Hox genes beyond their role of patterning genes, providing a new dimension to their functional relevance in the central nervous system.

  7. Generational Patterns in Mexican Americans' Academic Performance in an Unwelcoming Political Context.

    Science.gov (United States)

    Moosmann, Danyel A V; Roosa, Mark W; Knight, George P

    2014-03-01

    Research has shown that immigrant students often do better academically than their U.S.-born peers from the same ethnic group but it is unclear whether this pattern holds for Mexican Americans. We examined the academic performance of four generations of Mexican American students from fifth to 10th grade looking for generation differences and explanations for them. Using data from 749 families, we tested a model with fifth grade variables that differed by generation as potential mediators linking student generation to 10th grade academic performance. Results showed that immigrants were academically behind at fifth grade but caught up by seventh. Only economic hardship mediated the long term relationship between student generation and 10th grade academic performance; maternal educational expectations and child language hassles, English usage, discrimination, and mainstream values helped explained the early academic deficit of immigrant children. The results identified potential targets for interventions to improve Mexican American students' academic performance.

  8. Simulation of an offshore wind farm using fluid power for centralized electricity generation

    Science.gov (United States)

    Jarquin-Laguna, A.

    2016-09-01

    A centralized approach for electricity generation within a wind farm is explored through the use of fluid power technology. This concept considers a new way of generation, collection and transmission of wind energy inside a wind farm, in which electrical conversion does not occur during any intermediate conversion step before the energy has reached the offshore central platform. A numerical model was developed to capture the relevant physics from the dynamic interaction between different turbines coupled to a common hydraulic network and controller. This paper presents two examples of the time-domain simulation results for an hypothetical hydraulic wind farm subject to turbulent wind conditions. The performance and operational parameters of individual turbines are compared with those of a reference wind farm with conventional technology turbines, using the same wind farm layout and environmental conditions. For the presented case study, results indicate that the individual wind turbines are able to operate within operational limits with the current pressure control concept. Despite the stochastic turbulent wind input and wake effects, the hydraulic wind farm is able to produce electricity with reasonable performance in both below and above rated conditions.

  9. Overhaul of the generator of the hydroelectric central station Ingeniero Carlos Ramirez Ulloa; Rehabilitacion del generador de la unidad 2 de la central hidroelectrica ingeniero Carlos Ramirez Ulloa

    Energy Technology Data Exchange (ETDEWEB)

    Robles Pimentel, Edgar [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Garcia Hernandez, Javier [Comision Federal de Electricidad, Mexico, D. F. (Mexico)

    1997-12-31

    In November 1995, the failure of the Unit 2 generator at the hydroelectric central station Ingeniero Carlos Ramirez Ulloa, El Caracol, occurred. The accident forced to carry out its overhaul. Here are presented the technical problems faced during the overhaul of the generator and analyzed the implemented solutions. [Espanol] En noviembre de 1995 ocurrio la falla del generador de la unidad 2 de la central hidroelectrica Ing. Carlos Ramirez Ulloa, El Caracol. El accidente obligo a llevar a cabo su rehabilitacion. Se presentan los problemas tecnicos enfrentados durante la rehabilitacion del generador y se discuten las soluciones implementadas.

  10. Socio-Economic Factors Affecting Home Internet Usage Patterns in Central Queensland

    Directory of Open Access Journals (Sweden)

    Wal J. Taylor

    2003-01-01

    Full Text Available Governments and other policy makers are concerned with the gap in home Internet usage between people from metropolitan and rural areas. A survey conducted in Central Queensland, Australia examined differences in home Internet usage patterns between young and old, male and female, people in urban and rural areas, married and unmarried, well-educated and less educated, rich and poor, and employed and unemployed and found significant differences. These results highlight areas for further research and provide a basis for government agencies and industries to consider these associations in future policy formulation for regional development using ICT. The research suggested that further research should be conducted to monitor consuming behaviors of the youngest age group in Internet use for entertainment and information search in order to detect possible Internet overuse or addiction. In addition, further research should be conducted to find out what people search for on the Internet, and if for employment opportunities, financial incentives are suggested for the unemployed people.

  11. Morphotectonic analysis, structural evolution/pattern of a contractional ridge: Giouchtas Mt., Central Crete, Greece

    Indian Academy of Sciences (India)

    Kokinou Eleni; Skilodimou Hariklia D; Bathrellos George D; Antonarakou Assimina; Kamberis Evangelos

    2015-04-01

    The Giouchtas Mountain is situated south of Heraklion, Central Crete. It is a N–S trending morphological asymmetric ridge with a steep western slope, whilst its eastern slope is characterized by a smoother relief, composed of Mesozoic limestone and Eocene–lower Oligocene flysch of the Gavrovo–Tripolis zone. The present study focusses on the structural pattern and development of Giouchtas Mountain. Morphotectonic analyses in combination with field mapping and tectonic analysis were performed for this purpose. GIS techniques were used for mapping the spatial distribution of the geological features on the topographic relief of the area. Geomorphic indices, used in the present study, are the mountain front sinuosity index (Smf) and the valley floor/width ratio index (Vf). Based on Smf and Vf values, it is implied that this area can be assigned to a tectonic class I, corresponding to higher tectonic activity. However, spatial variations of the tectonic activity along the segmented fronts point to a general trend of increasing activity towards the north and especially, northeast. The model of this possibly active structural feature corresponds to a compressional mechanism followed by an earliest Mid. Miocene to Holocene late-stage deformation related to extensional faulting.

  12. Distribution pattern and conservation of threatened medicinal and aromatic plants of Central Himalaya, India

    Institute of Scientific and Technical Information of China (English)

    L. S. Kandari; K.S. Rao; R. K. Maikhuri; G. Kharkwal; K. Chauhan; C.P. Kala

    2011-01-01

    A study was conducted to examine the distribution pattern of four rhizomatous medicinal and aromatic plant species (MAPs) viz., Angelica glauca, Pleurospermum angelicoides, Rheum emodi and Arne- bia benthamii in different forest stands in Central Himalaya. Results show that A. Glauca and P. Angelicoides had a higher (50%) frequency at Chipkoan, Garpak and Phagati forest, R. Emodi had a higher (60%) fre- quency at Rishikund, Suki and Himtoli, and A. Benthamii had a higher (70%) frequency at Suki and Khambdhar The densities of A. Glauca (0.6 plants·m) and P. Angelicoides (0.5 plants·m) were higher at Chipkoan and Garpak sites than at other micro-sites, while densities of R. Emodi (0.8 plants·m) and A. Benthamii (1.0 plants·m) were higher at Suki and Khambdhar sites. A. Glauca had highest total basal covers (TBC) (1.2 cm·m) at Chipkoan, P. Angelicoides had highest TBC (0.92 cm·m) at Lati kharak site, A. Benthamii had the highest TBC (6.48 cm·m) at Khambdhar, and R. Emodi had highest TBC (4.53 cm·m) at Rishikund. For the four studied species, A. Glauca showed a contagious distribution, P. Angelicoides and R. Emodi showed the random and A. Benthamii showed the regular type of distribution.

  13. Deleterious Emission Abatement through Structured Energy Use Pattern: A North Central Nigeria Perspective

    Directory of Open Access Journals (Sweden)

    Ajayi-Banji Ademola

    2016-05-01

    Full Text Available Holistic view of household energy consumption based on greenhouse gas emissions in the North Central cities of Nigeria was examined in this study. Scenarios considered were based on income level of energy users (low and high and energy metering system (i.e. pre-paid and post-paid energy billing systems. Strong direct nexus was observed between energy use and emissions pattern. Energy utilization by post-paid category had higher weekly average value of 35.09 and 41.70 kWh as against 23.18 and 33.38 kWh for low and high income pre-paid consumers respectively. Energy use and greenhouse gas emissions from both classification followed similar trend. Data obtained and analysed in the study show that global warming and acidification potentials could be reduced by 33.94 and 19.95 % for low and high income category consumers when pre-paid meters are in place. Conclusively, energy system users with pre-paid metering system displayed reasonable level of management decisions that reduce energy wastage and consequently environmental negative impacts.

  14. Deleterious Emission Abatement through Structured Energy Use Pattern: A North Central Nigeria Perspective

    Science.gov (United States)

    Ajayi-Banji, Ademola; Omotosho, Olayinka; Amori, Anthony; Alao, Damilola; Igbode, Imoisime; Abimbola, Olufemi

    2016-05-01

    Holistic view of household energy consumption based on greenhouse gas emissions in the North Central cities of Nigeria was examined in this study. Scenarios considered were based on income level of energy users (low and high) and energy metering system (i.e. pre-paid and post-paid energy billing systems). Strong direct nexus was observed between energy use and emissions pattern. Energy utilization by post-paid category had higher weekly average value of 35.09 and 41.70 kWh as against 23.18 and 33.38 kWh for low and high income pre-paid consumers respectively. Energy use and greenhouse gas emissions from both classification followed similar trend. Data obtained and analysed in the study show that global warming and acidification potentials could be reduced by 33.94 and 19.95 % for low and high income category consumers when pre-paid meters are in place. Conclusively, energy system users with pre-paid metering system displayed reasonable level of management decisions that reduce energy wastage and consequently environmental negative impacts.

  15. Segmentation pattern and structural complexities in seismogenic extensional settings: The North Matese Fault System (Central Italy)

    Science.gov (United States)

    Ferrarini, Federica; Boncio, Paolo; de Nardis, Rita; Pappone, Gerardo; Cesarano, Massimo; Aucelli, Pietro P. C.; Lavecchia, Giusy

    2017-02-01

    We investigated the northern slope of the Matese Mts. (Molise, Central Italy) with the aim of characterizing the N- to NE-dipping active normal fault system in the Bojano basin, a sector of primary importance from a seismic hazard perspective. We collected field data to define the geometry and segmentation pattern of two sub-systems (Patalecchia-Colle di Mezzo and Bojano-Campochiaro). New evidence of late Quaternary faulting was obtained by exploiting well log interpretations. Kinematic analysis revealed the interaction of pre-Quaternary inherited (mainly E-W-striking) and newly formed (NW-SE-striking) normal faults. Slip accommodation through linkage was clearly noted in the case of the Patalecchia-Colle di Mezzo sub-system. Detailed topographic profiles across the active fault segments provided post-LGM (15 ± 3 kyr) slip rates up to ∼2 mm/yr which agree with the high deformation rates based on different approaches in the literature. Finally, the instrumental seismicity analysis constrained the bottom of the seismogenic layer to depths of 13-14 km, and the gathered information allowed us to reconstruct the North Matese seismogenic source. Its 3D geometry and dimensions agree with both the dimension-magnitude relationships and macroseismic information available for the 1805 earthquake (Mw 6.6), the main historical earthquake to have struck the Bojano basin.

  16. Current Vegetation Pattern along Glacial Landscape in Central (Garhwal) Himalaya, India

    Institute of Scientific and Technical Information of China (English)

    Uday N. Gaur; G.P. Raturi; A.B. Bhatt

    2005-01-01

    Current vegetation patterns, biodiversity and adaptation of plants were studied during 1998~2001 in glacial landscape of Chaurabari situated above Kedarnath (30° 44′ N~ 79° 07′ E;3,000~ 6,000 m) in Central Himalaya. Landscape was identified into different zones on account of the vegetation status, glacial features, geomorphology and altitudes. Cold environment with heavy snowfall, frost hailstorm and dense frost characterizes the study area.Predominance of the soda rich feldspars indicates soda enrichment; orthoclase, microcline weathering and alternation would have contributed potash to the soil. The increasing severity of the environment as we ascend from timberline to snowline leads to progressive decline in the abundance and diversity of the plant species. The diversity of the higher plants decrease, while the diversity of microflora increase from alpine zone to snowline zone. Highly opulent and diverse flora with beautiful, delicate herbs occupy the alpine zone, but some specialized groups of the plants, particularly high energetic and cold resistant species reside in glacial environment. Asteraceae,Rananculaceae, Primulaceae, Rosaceae, Apiaceae and Ericaceae are the pioneer angiospermic families,while Anaphalis triplinervis, A. royleana,Androsacce sarmentosa, Cotoneaster rotundifolius,Lonicera myrtillus, Cassiope fastigiata, Gaultheria trichophglla and Erigeron multiradiatus are the pioneer species, which have invaded in glacial environment. Through its nature, alpine glacial ecotone can be seen easily due to environmental and edaphic differences.

  17. Production patterns of packaging waste categories generated at typical Mediterranean residential building worksites

    Energy Technology Data Exchange (ETDEWEB)

    González Pericot, N., E-mail: natalia.gpericot@upm.es [Escuela Técnica Superior de Edificación, Universidad Politécnica de Madrid, Calle Juan de Herrera n°6, 28040 Madrid (Spain); Villoria Sáez, P., E-mail: paola.villoria@upm.es [Escuela Técnica Superior de Edificación, Universidad Politécnica de Madrid, Calle Juan de Herrera n°6, 28040 Madrid (Spain); Del Río Merino, M., E-mail: mercedes.delrio@upm.es [Escuela Técnica Superior de Edificación, Universidad Politécnica de Madrid, Calle Juan de Herrera n°6, 28040 Madrid (Spain); Liébana Carrasco, O., E-mail: oscar.liebana@uem.es [Escuela de Arquitectura, Universidad Europea de Madrid, Calle Tajo s/n, 28670 Villaviciosa de Odón (Spain)

    2014-11-15

    Highlights: • On-site segregation level: 1.80%; training and motivation strategies were not effective. • 70% Cardboard waste: from switches and sockets during the building services stage. • 40% Plastic waste: generated during structures and partition works due to palletizing. • >50% Wood packaging waste, basically pallets, generated during the envelope works. - Abstract: The construction sector is responsible for around 28% of the total waste volume generated in Europe, which exceeds the amount of household waste. This has led to an increase of different research studies focusing on construction waste quantification. However, within the research studies made, packaging waste has been analyzed to a limited extent. This article focuses on the packaging waste stream generated in the construction sector. To this purpose current on-site waste packaging management has been assessed by monitoring ten Mediterranean residential building works. The findings of the experimental data collection revealed that the incentive measures implemented by the construction company to improve on-site waste sorting failed to achieve the intended purpose, showing low segregation ratios. Subsequently, through an analytical study the generation patterns for packaging waste are established, leading to the identification of the prevailing kinds of packaging and the products responsible for their generation. Results indicate that plastic waste generation maintains a constant trend throughout the whole construction process, while cardboard becomes predominant towards the end of the construction works with switches and sockets from the electricity stage. Understanding the production patterns of packaging waste will be beneficial for adapting waste management strategies to the identified patterns for the specific nature of packaging waste within the context of construction worksites.

  18. Gondwana subduction-modified mantle domain prevents magmatic seafloor generation in the Central Indian Ridge

    Science.gov (United States)

    Morishita, T.; Nakamura, K.; Senda, R.; Suzuki, K.; Kumagai, H.; Sato, H.; Sato, T.; Shibuya, T.; Minoguchi, K.; Okino, K.

    2013-12-01

    The creation of oceanic crust at mid-ocean ridges is essential to understanding the genesis of oceanic plate and the evolution of the Earth. Detailed bathymetric measurements coupled with dense sample recovery at mid-ocean ridge revealed a wide range of variations in the ridge and seafloor morphologies, which cannot be simply explained by a spreading rate, but also by ridge geometry, mantle compositions and thermal structure (Dick et al., 2003 Nature; Cannat et al. 2006 Geology). It is now widely accepted that very limited magmatic activity with tectonic stretching generates oceanic core complex and/or smooth seafloor surface in the slow to ultraslow-spreading ridges, where serpentinized peridotite and gabbros are expected to be exposed associated with detachment faults (Cann et al., 1997 Nature; Cannat et al., 2006), although magmatism might be an essential role for the formation of oceanic core complexes (Buck et al., 2005 Nature; Tucholke et al 2008 JGR). A rising question is why magmatic activity is sometimes prevented during the oceanic plate formation. Ancient melting domain, that are too refractory to melt even in adiabatically upwelling to the shallow upper mantle, might cause the amagmatic spreading ridges (Harvey et al., 2006 EPSL, Liu et al.,2008 Nature). Its origin and effect on seafloor generations are, however, not well understood yet. We report an oceanic hill as an example of an ancient subduction-modified mantle domain, probably formed at continental margin of the Gondwanaland~Pangea supercontinent, existing beneath the Central Indian Ridge. This domain is the most likely to have prevented magmatic seafloor generation, resulting in creation of very deep oceanic valley and serpentine diaper (now the studied oceanic hill) at the present Central Indian ridge.

  19. Sequential generation of two distinct synapse-driven network patterns in developing neocortex.

    Science.gov (United States)

    Allène, Camille; Cattani, Adriano; Ackman, James B; Bonifazi, Paolo; Aniksztejn, Laurent; Ben-Ari, Yehezkel; Cossart, Rosa

    2008-11-26

    Developing cortical networks generate a variety of coherent activity patterns that participate in circuit refinement. Early network oscillations (ENOs) are the dominant network pattern in the rodent neocortex for a short period after birth. These large-scale calcium waves were shown to be largely driven by glutamatergic synapses albeit GABA is a major excitatory neurotransmitter in the cortex at such early stages, mediating synapse-driven giant depolarizing potentials (GDPs) in the hippocampus. Using functional multineuron calcium imaging together with single-cell and field potential recordings to clarify distinct network dynamics in rat cortical slices, we now report that the developing somatosensory cortex generates first ENOs then GDPs, both patterns coexisting for a restricted time period. These patterns markedly differ by their developmental profile, dynamics, and mechanisms: ENOs are generated before cortical GDPs (cGDPs) by the activation of glutamatergic synapses mostly through NMDARs; cENOs are low-frequency oscillations (approximately 0.01 Hz) displaying slow kinetics and gradually involving the entire network. At the end of the first postnatal week, GABA-driven cortical GDPs can be reliably monitored; cGDPs are recurrent oscillations (approximately 0.1 Hz) that repetitively synchronize localized neuronal assemblies. Contrary to cGDPs, cENOs were unexpectedly facilitated by short anoxic conditions suggesting a contribution of glutamate accumulation to their generation. In keeping with this, alterations of extracellular glutamate levels significantly affected cENOs, which are blocked by an enzymatic glutamate scavenger. Moreover, we show that a tonic glutamate current contributes to the neuronal membrane excitability when cENOs dominate network patterns. Therefore, cENOs and cGDPs are two separate aspects of neocortical network maturation that may be differentially engaged in physiological and pathological processes.

  20. Development and tracking of central patterns of subcutaneous fat of rural South African youth: Ellisras longitudinal study

    Directory of Open Access Journals (Sweden)

    Kemper Han CG

    2009-12-01

    Full Text Available Abstract Background Individuals grow and accumulate central patterns of body fat into the diseases they will suffer from as older adults. The need to elicit the development and tracking of central patterns of body fat from younger age into adolescent remains to be explored. Method Skinfolds measurements were done according to the standard procedures in the Ellisras Longitudinal Growth and Health Study. In total, 2,225 children--550 preschool and 1,675 primary school--aged 3-10 years (birth cohorts 1993 to 1986 were enrolled at baseline in 1996 and followed through out the eight-year periodic surveys. In 2003, 1,771 children--489 preschool and 1,282 primary school--were still in the study. Results The development of triceps, biceps, suprailiac and suscapular skinfolds of Ellisras girls were significantly higher (p Conclusion The accumulation of central patterns of body fat of Ellisras children starts in childhood and adolescence spurt with Ellisras girls acquiring more than boys over time. High significant tracking of skinfold thickness while the skinfold ratios show low and insignificant tracking over time. The magnitude of central patterns of body fat accumulation over time requires further investigation to clarify their association with risk factors for cardiovascular diseases.

  1. Walking Pattern Generation of Dual-Arm Mobile Robot Using Preview Controller

    Directory of Open Access Journals (Sweden)

    P. Wu

    2012-09-01

    Full Text Available Based on the stability request of robot’s moving on the ground, the motion planning of dual-arm mobile robot when moving on the ground is studied and the preview control system is applied in the robot walking pattern generation. Direct question of robot kinematics in the extended task space is analyzed according to Degrees of Freedom configuration of the dual-arm mobile robot. It is proved that the preview control system could be used in the generation of robot Center of Mass forward trajectory through the building of double linear inverted pendulum model of dual-arm mobile robot. The sector gridding search algorithm is proposed and the reachable workspace which meets the Zero Moment Point stability principle when the robot moving on the ground is obtained. Tip Trajectory is generated through polynomial interpolation. Each joint curve is calculated using MATLAB which is imported to virtual physical model. The feasibility of gait generation is verified.

  2. Seismotectonic pattern and the source region of volcanism in the central part of Sunda Arc

    Science.gov (United States)

    Špičák, Aleš; Hanuš, Václav; Vaněk, Jiří

    2005-07-01

    The seismotectonic pattern in the central part of the Sunda Arc (Java, Nusa Tenggara) was studied in relation to the distribution of active calc-alkaline volcanoes, using global seismological data. Hypocentral determinations of the International Seismological Centre from the period 1964-1999, as relocated by Engdahl, and Harvard Centroid Moment Tensor Solutions from the period 1976-2003 were used. The following phenomena, which could assist the location of the source region of primary magma for island arc calc-alkaline volcanism, were observed: (1) An aseismic gap without any strong teleseismically recorded earthquakes was found in the Wadati-Benioff zone of the subducting slab along the whole investigated region of the Sunda Arc, forming a continuous strip of laterally variable depth and shape, at depths between 100 and 200 km. The absence of strong earthquakes (with mb>4.0) indicates a significant change in the mechanical properties of the subducting slab at intermediate depths. All active calc-alkaline volcanoes in the Sunda Arc are located above this gap. (2) The majority of earthquakes occurring in the lithospheric wedge of the Eurasian Plate above the subducted slab could be attributed to several deep-rooted seismically active fracture zones of regional extent. All delineated active fracture zones display a thrust tectonic regime as shown by the available fault plane solutions. (3) Clusters of earthquakes were found beneath active volcanoes of western Java, Bali and Nusa Tenggara in the lithospheric wedge above the slab and identified as seismically active columns. These clusters occur only beneath the volcanoes that are located at the outcrops of seismically active fracture zones. We interpret the earthquakes in these clusters beneath volcanoes as events induced by magma transport through the medium of the lithospheric wedge that has been subcritically pre-stressed by the process of plate convergence. (4) Beneath the volcanoes of central Java no seismically

  3. SOM-based Pattern Generator: Pattern Generation Based on the Backward Projection in a Self-Organizing Map and Its Applications

    Science.gov (United States)

    Wakuya, Hiroshi; Ishiguma, Takahiro

    A major feature of the self-organizing map (SOM) is a topology-preserving projection from the input layer to the competitive layer, and it has been used mainly as an analytical tool for discovering underlying rules in the given data set. Even though recent splendid progress in this area, there are few novel ideas to break such a conventional style. On the contrary, based on its distinctive nature, a new method for generating patterns through backward projection from the competitive layer to the input layer is proposed recently. Moreover, a promising technology for producing animation as a series of backward-projected patterns along with any pathways on the competitive layer is presented. Then, in order to carry out further considerations, some computer simulations with a variety of posed stick figures are tried in this paper. After training, four kinds of pathways, which correspond to different movements such as dancing, exercising and walking, are prepared. Though some of them does not contain any training samples, all of them worked well as we have intended in advance. As a result, it is found that the proposed method shows good performance and it is also confirmed its effectiveness.

  4. Patterns of mercury dispersion from local and regional emission sources, rural Central Wisconsin, USA

    Directory of Open Access Journals (Sweden)

    A. Kolker

    2010-05-01

    Full Text Available Simultaneous real-time changes in mercury (Hg speciation- reactive gaseous Hg (RGM, elemental Hg (Hg°, and fine particulate Hg (Hg-PM2.5, were determined from June to November, 2007, in ambient air at three locations in rural Central Wisconsin. Known Hg emission sources within the airshed of the monitoring sites include: 1 a 1114 megawatt (MW coal-fired electric utility generating station; 2 a Hg-bed chlor-alkali plant; and 3 a smaller (465 MW coal-burning electric utility. Monitoring sites, showing sporadic elevation of Hg°, Hg-PM2.5, and RGM were positioned at distances of 25, 50 and 100 km northward of the larger electric utility. Median concentrations of Hg°, Hg-PM2.5, and RGM were 1.3–1.4 ng m−3, 2.6–5.0 pg m−3, and 0.6–0.8 pg m−3, respectively. A series of RGM events were recorded at each site. The largest, on 23 September, occurred under prevailing southerly winds, with a maximum RGM value (56.8 pg m-3 measured at the 100 km site, and corresponding elevated SO2 (10.4 ppbv; measured at 50 km site. The finding that RGM, Hg°, and Hg-PM2.5 are not always highest at the 25 km site, closest to the large generating station, contradicts the idea that RGM decreases with distance from a large point source. This may be explained if: 1 the 100 km site was influenced by emissions from the chlor-alkali facility or by RGM from regional urban sources; 2 the emission stack height of the larger power plant promoted plume transport at an elevation where the Hg is carried over the closest site; or 3 RGM was being generated in the plume through oxidation of Hg°. Operational changes at each emitter since 2007 should reduce their Hg output, potentially allowing quantification of the environmental benefit in future studies.

  5. Hydrological processes and chemical characteristics of low-alpine patterned wetlands, south-central New Zealand

    Science.gov (United States)

    Chagué-Goff, Catherine; Mark, Alan F.; Dickinson, Katharine J. M.

    2010-05-01

    SummaryPatterned wetlands in New Zealand are not only rare, but they are distinguished from their Northern Hemisphere counterparts by their vegetation and the supply of rainfall which is relatively free of pollution. Hydrological processes in two low-alpine patterned wetlands (5 and 220 ha) on block-faulted uplands in south-central South Island, New Zealand were investigated using hydraulic head gradients, and chemical and isotope data. There was no significant spatial variability in chemical parameters within either wetland, although the larger wetland is characterised by a lower trophic status than the smaller one. Ca 2+ concentrations and pH of surface water of both wetlands are within the range of that of Northern Hemisphere ombrotrophic/mesotrophic bogs and poor fens. Pool water chemistry only partially overlaps with the lower end of the Ca 2+ distribution for the Northern Hemisphere wetlands, likely to be caused by the low level of Ca 2+ in aeolian dust. The pH in the pools of the small wetland was generally higher, probably as a result of differing organic acid production by the Sphagnum and sedge species, both of which were common and dominant or sub-dominant in the wetlands. Some temporal variability was observed, possibly due to seasonal variations in plant uptake and/or rainfall. A steady increase in Na + concentrations in the pools over 4 years was tentatively attributed to an excess of supply from rainfall and/or groundwater. Cation and stable isotope data indicate strong evaporation in pools and surface water, despite the high ambient relative humidity, and mixing within the top of the wetland sequence. Stratigraphy indicates that peat formation has been interrupted by flooding or runoff, bringing mineral matter into the wetlands, particularly in the earlier development stages of the larger wetland. The peat sequence is thicker in the smaller wetland, reaching up to 2.8 m, with limited mineral input during wetland development. The relatively low p

  6. Two-phase Flow Patterns in High Temperature Generator of Absorption Chiller / Heater

    Science.gov (United States)

    Furukawa, Masahiro; Kanuma, Hitoshi; Sekoguchi, Kotohiko; Takeishi, Masayuki

    There is a lack of information about vapor-liquid two-phase flow patterns determined using void signals in high temperature generator of absorption chiller/heater. Sensing void fraction has been hampered because lithium bromide aqueous solution of strong alkalinity is employed as working fluid at high temperature and high level of vacuum. New void sensor applicable to such difficult conditions was developed. The void Fractions at 48 locations in a high temperature generator were measured simultaneously in both cooling and heating operations. Analysis of void signals detected reveals that the most violent boiling occurs at the upper part of rear plate of combustion chamber and the first line of vertical tubes located in the flue. The flow patterns are strongly affected by the system pressure difference between the cooling and heating operations: there appear bubbly, slug and froth flows in the cooling operation, but only bubbly flow in the heating operation.

  7. Lithographic deposition of patterned metal-organic framework coatings using a photobase generator.

    Science.gov (United States)

    Keitz, Benjamin K; Yu, Chung Jui; Long, Jeffrey R; Ameloot, Rob

    2014-05-26

    A photobase generator was used to induce metal-organic framework (MOF) nucleation upon UV irradiation. This method was further developed into a simple, one-step method for depositing patterned MOF films. Furthermore, the ability of our method to coat a single substrate with MOF films having different chemical compositions is illustrated. The method is an important step towards integrating MOF deposition with existing lithographic techniques and the incorporation of these materials into sensors and other electronic devices.

  8. Towards pattern generation and chaotic series prediction with photonic reservoir computers

    Science.gov (United States)

    Antonik, Piotr; Hermans, Michiel; Duport, François; Haelterman, Marc; Massar, Serge

    2016-03-01

    Reservoir Computing is a bio-inspired computing paradigm for processing time dependent signals that is particularly well suited for analog implementations. Our team has demonstrated several photonic reservoir computers with performance comparable to digital algorithms on a series of benchmark tasks such as channel equalisation and speech recognition. Recently, we showed that our opto-electronic reservoir computer could be trained online with a simple gradient descent algorithm programmed on an FPGA chip. This setup makes it in principle possible to feed the output signal back into the reservoir, and thus highly enrich the dynamics of the system. This will allow to tackle complex prediction tasks in hardware, such as pattern generation and chaotic and financial series prediction, which have so far only been studied in digital implementations. Here we report simulation results of our opto-electronic setup with an FPGA chip and output feedback applied to pattern generation and Mackey-Glass chaotic series prediction. The simulations take into account the major aspects of our experimental setup. We find that pattern generation can be easily implemented on the current setup with very good results. The Mackey-Glass series prediction task is more complex and requires a large reservoir and more elaborate training algorithm. With these adjustments promising result are obtained, and we now know what improvements are needed to match previously reported numerical results. These simulation results will serve as basis of comparison for experiments we will carry out in the coming months.

  9. Infiltration Pattern of Blood Monocytes into the Central Nervous System during Experimental Herpes Simplex Virus Encephalitis.

    Directory of Open Access Journals (Sweden)

    Rafik Menasria

    Full Text Available The kinetics and distribution of infiltrating blood monocytes into the central nervous system and their involvement in the cerebral immune response together with resident macrophages, namely microglia, were evaluated in experimental herpes simplex virus 1 (HSV-1 encephalitis (HSE. To distinguish microglia from blood monocyte-derived macrophages, chimeras were generated by conditioning C57BL/6 recipient mice with chemotherapy regimen followed by transplantation of bone morrow-derived cells that expressed the green fluorescent protein. Mice were infected intranasally with a sub-lethal dose of HSV-1 (1.2 x 10(6 plaque forming units. Brains were harvested prior to and on days 4, 6, 8 and 10 post-infection for flow cytometry and immunohistochemistry analysis. The amounts of neutrophils (P < 0.05 and "Ly6C hi" inflammatory monocytes (P < 0.001 significantly increased in the CNS compared to non-infected controls on day 6 post-infection, which corresponded to more severe clinical signs of HSE. Levels decreased on day 8 for both leukocytes subpopulations (P < 0.05 for inflammatory monocytes compared to non-infected controls to reach baseline levels on day 10 following infection. The percentage of "Ly6C low" patrolling monocytes significantly increased (P < 0.01 at a later time point (day 8, which correlated with the resolution phase of HSE. Histological analysis demonstrated that blood leukocytes colonized mostly the olfactory bulb and the brainstem, which corresponded to regions where HSV-1 particles were detected. Furthermore, infiltrating cells from the monocytic lineage could differentiate into activated local tissue macrophages that express the microglia marker, ionized calcium-binding adaptor molecule 1. The lack of albumin detection in the brain parenchyma of infected mice showed that the infiltration of blood leukocytes was not necessarily related to a breakdown of the blood-brain barrier but could be the result of a functional recruitment. Thus

  10. Infiltration Pattern of Blood Monocytes into the Central Nervous System during Experimental Herpes Simplex Virus Encephalitis

    Science.gov (United States)

    Menasria, Rafik; Canivet, Coraline; Piret, Jocelyne; Boivin, Guy

    2015-01-01

    The kinetics and distribution of infiltrating blood monocytes into the central nervous system and their involvement in the cerebral immune response together with resident macrophages, namely microglia, were evaluated in experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE). To distinguish microglia from blood monocyte-derived macrophages, chimeras were generated by conditioning C57BL/6 recipient mice with chemotherapy regimen followed by transplantation of bone morrow-derived cells that expressed the green fluorescent protein. Mice were infected intranasally with a sub-lethal dose of HSV-1 (1.2x106 plaque forming units). Brains were harvested prior to and on days 4, 6, 8 and 10 post-infection for flow cytometry and immunohistochemistry analysis. The amounts of neutrophils (P<0.05) and «Ly6Chi» inflammatory monocytes (P<0.001) significantly increased in the CNS compared to non-infected controls on day 6 post-infection, which corresponded to more severe clinical signs of HSE. Levels decreased on day 8 for both leukocytes subpopulations (P<0.05 for inflammatory monocytes compared to non-infected controls) to reach baseline levels on day 10 following infection. The percentage of «Ly6Clow» patrolling monocytes significantly increased (P<0.01) at a later time point (day 8), which correlated with the resolution phase of HSE. Histological analysis demonstrated that blood leukocytes colonized mostly the olfactory bulb and the brainstem, which corresponded to regions where HSV-1 particles were detected. Furthermore, infiltrating cells from the monocytic lineage could differentiate into activated local tissue macrophages that express the microglia marker, ionized calcium-binding adaptor molecule 1. The lack of albumin detection in the brain parenchyma of infected mice showed that the infiltration of blood leukocytes was not necessarily related to a breakdown of the blood-brain barrier but could be the result of a functional recruitment. Thus, our findings suggest

  11. Development of Central Monitoring System for Insulation Diagnosis of High-Voltage Generator/Motor Stator Windings

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Byoung Chol; Yoon, Dae Hee; Hwang, Don Ha; Kim, Yong Joo [Mechatronics Research Group, Korea Electrotechnology Research Institute (Korea); Ju, Young Ho [Korea Electric Power Corporation (Korea); Kim, Jeong Woo [Advanced Electronic Technology Co., Ltd. (Korea)

    2000-07-01

    The central monitoring system with on-line diagnosis of high-voltage generator/motor stator insulation is developed. The system is capable of remote diagnosis and monitoring partial discharges of high-voltage generator/motor stator insulation. GOMS(Generator On-line Monitoring System) with maximum of 9 input channels can measure stator insulation by on-line. The measured and analysis data are borough to the central monitoring system via modem to build database. The central monitoring system can diagnose and monitor the insulation status of several high-voltage generator/motor at any time. The insulation status of those machines can be enhanced by the database on partial discharges. (author). 9 refs., 3 figs., 2 tabs.

  12. Variable resolution pattern generation for the Associative Memory of the ATLAS FTK project

    CERN Document Server

    Annovi, A; The ATLAS collaboration; Faulkner, G; Giannetti, P; Jiang, Z; Luongo, C; Pandini, C; Shochet, M; Tompkins, L; Volpi, G

    2013-01-01

    The Associative Memory (AM) chip is special device that allows to find coincidence patterns, or just patterns, between the incoming data in up to 8 parallel streams. The latest AM chip has been designed to receive silicon clusters generated in 8 layers of the ATLAS silicon detector sensor, to perform parallel track pattern matching at high rate and it will be the core of the FTK project. Data going through each of the busses are compared with a bank of patterns and AM chip looks for matches in each line, like commercial content addressable memory (CAM). The high density of hits expected in the ATLAS inner detector from 2015 put a challenge in the capability of the AM chip in rejecting random coincidences, requiring either an extremely high number of high precision patterns, with increasing costs and complexity of the system, or more flexible solutions. For this reason in the most recent prototype of the AM chip ternary cells have been added in the logic, allowing “don’t care” (DC) bits in the match. Hav...

  13. Direct observation of microcontact behaviours in pattern-generation step of reverse offset printing

    Science.gov (United States)

    Kusaka, Yasuyuki; Kanazawa, Shusuke; Yamamoto, Noritaka; Ushijima, Hirobumi

    2017-01-01

    In this study, we investigate the static and dynamic aspects of the nip formed during roll-to-sheet-type reverse offset printing. First, we show that several modes of roof collapses (bottom contact defects) could be formed depending on the poly(dimethylsiloxane) (PDMS) blanket thickness and pattern size. We regulate the manifestation of the defect modes driven by the local pile-up of the incompressible PDMS, as modelled by the contact mechanics formulation, together with a complementary numerical simulation. In dynamics, we first differentiate between the static nip and dynamic nip during printing, where the width is extended by the kinetically controlled adhesion of the blanket PDMS. Further, we observe that depending on the pattern structure, there was spatial deviation of the microscopic contact and subsequent separation behaviours of the cliché from a macroscopically recognizable nip, and consequently, local detachment rates were heterogeneous in the pattern-generation process of the reverse offset printing, even with a constant machine speed. In addition, we found that the parts of a pattern where the ink transfer fails in a high-speed patterning condition corresponded to the region of the locally enhanced detachment rates found during direct observation.

  14. NeuroPG: Open source software for optical pattern generation and data acquisition

    Directory of Open Access Journals (Sweden)

    Benjamin W. Avants

    2015-03-01

    Full Text Available Patterned illumination using a digital micromirror device (DMD is a powerful tool for optogenetics. Compared to a scanning laser, DMDs are inexpensive and can easily create complex illumination patterns. Combining these complex spatiotemporal illumination patterns with optogenetics allows DMD-equipped microscopes to probe neural circuits by selectively manipulating the activity of many individual cells or many subcellular regions at the same time. To use DMDs to study neural activity, scientists must develop specialized software to coordinate optical stimulation patterns with the acquisition of electrophysiological and fluorescence data. To meet this growing need we have developed an open source optical pattern generation software for neuroscience - NeuroPG - that combines, DMD control, sample visualization, and data acquisition in one application. Built on a MATLAB platform, NeuroPG can also process, analyze, and visualize data. The software is designed specifically for the Mightex Polygon400; however, as an open source package, NeuroPG can be modified to incorporate any data acquisition, imaging, or illumination equipment that is compatible with MATLAB’s Data Acquisition and Image Acquisition toolboxes.

  15. A Modified Design of Test Pattern Generator for Built-In-SelfTest Applications

    Directory of Open Access Journals (Sweden)

    Bharti Mishra

    2015-12-01

    Full Text Available Test Pattern Generators (TPG are very important logic part of the Circuits that have self-test features. Nowadays, the self-test feature is an in-built part of the modern application hardware designs. This feature enables the user to test and verify the specific hardware failure with the help of the hardware itself. To enable self-test an extra operational and control circuit is required by the application based operational and control circuit. The size of the self-test block is generally small as compared to the actual hardware. Most of the self-test hardware includes Linear Feedback Shift Register (LFSR to generate the test signal pattern in the self-test mode of circuit operation. In the present work a simple 3-FF based modified design of TPG is designed and simulated to generate a 4-bit test signal sequence. The present work also shows FPGA based simulation and synthesis of a 16-bit TPG design using the 4-bit TPG. The present TPG design concept can be replicated to generate a test sequence of higher bit length for advanced applications. The present design is simulated on Xilinx tool for functional verification.

  16. Implementation of a data packet generator using pattern matching for wearable ECG monitoring systems.

    Science.gov (United States)

    Noh, Yun Hong; Jeong, Do Un

    2014-07-15

    In this paper, a packet generator using a pattern matching algorithm for real-time abnormal heartbeat detection is proposed. The packet generator creates a very small data packet which conveys sufficient crucial information for health condition analysis. The data packet envelopes real time ECG signals and transmits them to a smartphone via Bluetooth. An Android application was developed specifically to decode the packet and extract ECG information for health condition analysis. Several graphical presentations are displayed and shown on the smartphone. We evaluate the performance of abnormal heartbeat detection accuracy using the MIT/BIH Arrhythmia Database and real time experiments. The experimental result confirm our finding that abnormal heart beat detection is practically possible. We also performed data compression ratio and signal restoration performance evaluations to establish the usefulness of the proposed packet generator and the results were excellent.

  17. K-Medoids-Based Random Biometric Pattern for Cryptographic Key Generation

    Science.gov (United States)

    Garcia-Baleon, H. A.; Alarcon-Aquino, V.; Starostenko, O.

    In this paper we report an approach for cryptographic key generation based on keystroke dynamics and the k-medoids algorithm. The stages that comprise the approach are training-enrollment and user verification. The proposed approach is able to verify the identity of individuals off-line avoiding the use of a centralized database. The performance of the proposed approach is assessed using 20 samples of keystroke dynamics from 20 different users. Simulation results show a false acceptance rate (FAR) of 5.26% and a false rejection rate (FRR) of 10%. The cryptographic key released by the proposed approach may be used in several encryption algorithms.

  18. Water supply patterns in two agricultural areas of Central Germany under climate change conditions

    Directory of Open Access Journals (Sweden)

    M. H. Tölle

    2012-04-01

    Full Text Available Increasing emissions of greenhouse gases and increasing prices for fossil fuels have highlighted the demand for CO2 "neutral" renewable energy sources, e.g. short rotation forestry systems used for bioenergy. These systems might be vulnerable to changes in temperature, precipitation and occurrence of extreme weather events. To estimate success or failure of such short rotation coppices in a certain area we need regional climate projections and risk assessment. Changes of water supply patterns in two agriculturally extensively used regions in Central Germany (around Göttingen and Großfahner with different climate conditions but both in the temperate climate zone are explored. The study is carried out under present conditions as well as under projected climate change conditions (1971–2100 using A1B and B1 climate scenarios downscaled for Europe. Analysis of precipitation bias shows regional differences: a strong bias in Göttingen area and a weaker bias in the Großfahner area. A bias correction approach, Quantile mapping, is applied to the ensemble results for both areas for winter and summer seasons. By using quantile regression on the seasonal Standardized Precipitation Indices (SPIs as indicator for water supply conditions we found that precipitation is expected to increase in winter in all quantiles of the distribution for Göttingen area during the 21th century. Heavy precipitation is also expected to increase for Großfahner area suggesting a trend to wetter extremes in winter for the future. This winter precipitation increase could trigger runoff and soil erosion risk enhancing the severity of floods. Increasing winter availability of water could enhance local water supply in spring. For both areas no significant change in summer was found over the whole time period. Although the climate change signal of the SPI indicate mild dryer conditions in summer at the end of the 21st century which may trigger water shortage and

  19. Water supply patterns in two agricultural areas of Central Germany under climate change conditions

    Science.gov (United States)

    Tölle, M. H.; Moseley, C.; Panferov, O.; Busch, G.; Knohl, A.

    2012-04-01

    Increasing emissions of greenhouse gases and increasing prices for fossil fuels have highlighted the demand for CO2 "neutral" renewable energy sources, e.g. short rotation forestry systems used for bioenergy. These systems might be vulnerable to changes in temperature, precipitation and occurrence of extreme weather events. To estimate success or failure of such short rotation coppices in a certain area we need regional climate projections and risk assessment. Changes of water supply patterns in two agriculturally extensively used regions in Central Germany (around Göttingen and Großfahner) with different climate conditions but both in the temperate climate zone are explored. The study is carried out under present conditions as well as under projected climate change conditions (1971-2100) using A1B and B1 climate scenarios downscaled for Europe. Analysis of precipitation bias shows regional differences: a strong bias in Göttingen area and a weaker bias in the Großfahner area. A bias correction approach, Quantile mapping, is applied to the ensemble results for both areas for winter and summer seasons. By using quantile regression on the seasonal Standardized Precipitation Indices (SPIs) as indicator for water supply conditions we found that precipitation is expected to increase in winter in all quantiles of the distribution for Göttingen area during the 21th century. Heavy precipitation is also expected to increase for Großfahner area suggesting a trend to wetter extremes in winter for the future. This winter precipitation increase could trigger runoff and soil erosion risk enhancing the severity of floods. Increasing winter availability of water could enhance local water supply in spring. For both areas no significant change in summer was found over the whole time period. Although the climate change signal of the SPI indicate mild dryer conditions in summer at the end of the 21st century which may trigger water shortage and summer drying associated with above

  20. A Novel Biped Pattern Generator Based on Extended ZMP and Extended Cart-table Model

    Directory of Open Access Journals (Sweden)

    Guangbin Sun

    2015-07-01

    Full Text Available This paper focuses on planning patterns for biped walking on complex terrains. Two problems are solved: ZMP (zero moment point cannot be used on uneven terrain, and the conventional cart-table model does not allow vertical CM (centre of mass motion. For the ZMP definition problem, we propose the extended ZMP (EZMP concept as an extension of ZMP to uneven terrains. It can be used to judge dynamic balance on universal terrains. We achieve a deeper insight into the connection and difference between ZMP and EZMP by adding different constraints. For the model problem, we extend the cart-table model by using a dynamic constraint instead of constant height constraint, which results in a mathematically symmetric set of three equations. In this way, the vertical motion is enabled and the resultant equations are still linear. Based on the extended ZMP concept and extended cart-table model, a biped pattern generator using triple preview controllers is constructed and implemented simultaneously to three dimensions. Using the proposed pattern generator, the Atlas robot is simulated. The simulation results show the robot can walk stably on rather complex terrains by accurately tracking extended ZMP.

  1. Micropunching lithography for generating micro- and submicron-patterns on polymer substrates.

    Science.gov (United States)

    Chakraborty, Anirban; Liu, Xinchuan; Luo, Cheng

    2012-07-02

    Conducting polymers have attracted great attention since the discovery of high conductivity in doped polyacetylene in 1977(1). They offer the advantages of low weight, easy tailoring of properties and a wide spectrum of applications(2,3). Due to sensitivity of conducting polymers to environmental conditions (e.g., air, oxygen, moisture, high temperature and chemical solutions), lithographic techniques present significant technical challenges when working with these materials(4). For example, current photolithographic methods, such as ultra-violet (UV), are unsuitable for patterning the conducting polymers due to the involvement of wet and/or dry etching processes in these methods. In addition, current micro/nanosystems mainly have a planar form(5,6). One layer of structures is built on the top surfaces of another layer of fabricated features. Multiple layers of these structures are stacked together to form numerous devices on a common substrate. The sidewall surfaces of the microstructures have not been used in constructing devices. On the other hand, sidewall patterns could be used, for example, to build 3-D circuits, modify fluidic channels and direct horizontal growth of nanowires and nanotubes. A macropunching method has been applied in the manufacturing industry to create macropatterns in a sheet metal for over a hundred years. Motivated by this approach, we have developed a micropunching lithography method (MPL) to overcome the obstacles of patterning conducting polymers and generating sidewall patterns. Like the macropunching method, the MPL also includes two operations (Fig. 1): (i) cutting; and (ii) drawing. The "cutting" operation was applied to pattern three conducting polymers(4), polypyrrole (PPy), Poly(3,4-ethylenedioxythiophen)-poly(4-styrenesulphonate) (PEDOT) and polyaniline (PANI). It was also employed to create Al microstructures(7). The fabricated microstructures of conducting polymers have been used as humidity(8), chemical(8), and glucose

  2. Evaluation method for a controller of active mass damper using central pattern generator

    Science.gov (United States)

    Hongu, Junichi; Iba, Daisuke; Nakamura, Morimasa; Moriwaki, Ichiro

    2013-04-01

    This paper proposes an evaluation method for a CPG controller designed for active mass dampers. Neural oscillators composing the CPG have nonlinear and entrainment properties. Therefore, the proposed controller has possibility to have flexibility, when the structural parameters, i.e. stiffness or damping, are changed by the effect of earthquakes and the like. However, there has been no study to evaluate the controller's above-mentioned properties. For tuning into practical application, the reliability and flexibility along with the controller's performance must be analyzed. In our previous study, the phase reduction theory was tried to appraise the synchronization between a structure and a single neural oscillator and the synchronization region of the neural oscillator was obtained as basic research. However, the information from the synchronization region was insufficient to evaluate the system, because the neural oscillator has a phase difference called a phase locking point between the structure and the neural oscillator during the synchronization. Then, in this paper, the phase locking point within the synchronization region between a structure and a single neural oscillator is focused on, and the phase locking point and the vibration mitigation effect are considered with the simple object model.

  3. Reduced Test Pattern Generation of Multiple SIC Vectors with Input and Output Delay Faults

    Directory of Open Access Journals (Sweden)

    P.T.Sairam

    2014-11-01

    Full Text Available In recent years, the design for low power has become one of the greatest challenges in high-performance very large scale integration (VLSI design. Most of the methods focus on the power consumption during normal mode operation, while test mode operation has not normally been a predominant concern. However, it has been found that the power consumed during test mode operation is often much higher than during normal mode operation [1]. This is because most of the consumed power results from the switching activity in the nodes of the circuit under test (CUT, which is much higher during test mode than during normal mode operation [1]–[3]. In the proposed pattern, each generated vector applied to each scan chain is an SIC vector, which can minimize the input transition and reduce test power. In VLSI testing, power reduction is achieved by increasing the correlation between consecutive test patterns.

  4. Rare earth element patterns of the Central Indian Basin sediments related to their lithology

    Digital Repository Service at National Institute of Oceanography (India)

    Nath, B.N.; Roelandts, I.; Sudhakar, M.; Pluger, W.L.

    Rare earth element (REE) concentration have been determined in terrigenous, siliceous (nodule barren and nodule bearing), calcareous, and red clay from the Central Indian Basin. The bulk distribution of REE, and in particular the relative cerium...

  5. Polarization pattern of vector vortex beams generated by q-plates with different topological charges.

    Science.gov (United States)

    Cardano, Filippo; Karimi, Ebrahim; Slussarenko, Sergei; Marrucci, Lorenzo; de Lisio, Corrado; Santamato, Enrico

    2012-04-01

    We describe the polarization topology of the vector beams emerging from a patterned birefringent liquid crystal plate with a topological charge q at its center (q-plate). The polarization topological structures for different q-plates and different input polarization states have been studied experimentally by measuring the Stokes parameters point-by-point in the beam transverse plane. Furthermore, we used a tuned q=1/2-plate to generate cylindrical vector beams with radial or azimuthal polarizations, with the possibility of switching dynamically between these two cases by simply changing the linear polarization of the input beam.

  6. Polarization pattern of vector vortex beams generated by $q$-plates with different topological charges

    CERN Document Server

    Cardano, Filippo; Slussarenko, Sergei; Marrucci, Lorenzo; de Lisio, Corrado; Santamato, Enrico

    2012-01-01

    We describe the polarization topology of the vector beams emerging from a patterned birefringent liquid crystal plate with a topological charge $q$ at its center ($q$-plate). The polarization topological structures for different $q$-plates and different input polarization states have been studied experimentally by measuring the Stokes parameters point-by-point in the beam transverse plane. Furthermore, we used a tuned $q=1/2$-plate to generate cylindrical vector beams with radial or azimuthal polarizations, with the possibility of switching dynamically between these two cases by simply changing the linear polarization of the input beam.

  7. Patterns of illness in travelers visiting Mexico and Central America: the GeoSentinel experience

    OpenAIRE

    Flores-Figueroa, J; Okhuysen, P C; von Sonnenburg, F.; DuPont, H L; Libman, M D; Keystone, J S; Hale, D C; Burchard, G.; Han, P V; Wilder-Smith, A; Freedman, D O

    2011-01-01

    BACKGROUND: Mexico and Central America are important travel destinations for North American and European travelers. There is limited information on regional differences in travel related morbidity. METHODS: We describe the morbidity among 4779 ill travelers returned from Mexico and Central America who were evaluated at GeoSentinel network clinics during December 1996 to February 2010. RESULTS: The most frequent presenting syndromes included acute and chronic diarrhea, dermat...

  8. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

    Directory of Open Access Journals (Sweden)

    Manya Warrier

    2015-01-01

    Full Text Available Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO have recently been linked to cardiovascular disease (CVD risk. Here, we performed transcriptional profiling in mouse models of altered reverse cholesterol transport (RCT and serendipitously identified the TMAO-generating enzyme flavin monooxygenase 3 (FMO3 as a powerful modifier of cholesterol metabolism and RCT. Knockdown of FMO3 in cholesterol-fed mice alters biliary lipid secretion, blunts intestinal cholesterol absorption, and limits the production of hepatic oxysterols and cholesteryl esters. Furthermore, FMO3 knockdown stimulates basal and liver X receptor (LXR-stimulated macrophage RCT, thereby improving cholesterol balance. Conversely, FMO3 knockdown exacerbates hepatic endoplasmic reticulum (ER stress and inflammation in part by decreasing hepatic oxysterol levels and subsequent LXR activation. FMO3 is thus identified as a central integrator of hepatic cholesterol and triacylglycerol metabolism, inflammation, and ER stress. These studies suggest that the gut microbiota-driven TMA/FMO3/TMAO pathway is a key regulator of lipid metabolism and inflammation.

  9. Total solar eclipse education for young generation at Palangkaraya, Central Kalimantan

    Science.gov (United States)

    Fatima, S.; Widyanita; Fahriyah, H.; Rhodiyah, A. K.; Satrya, C. D.; Hilmi, M.; Ramadhania, G. E.; Naufal, L.; Mulki, F. A. M.; Herdiwijaya, D.

    2016-11-01

    The path of Total Solar Eclipse (TSE) on March 9th 2016 passed through several cities in Indonesia and one of them is Palangkaraya, Central Kalimantan. The TSE natural phenomenon provided a special moment and gave unforgettable and lifelong experiences for children who live in Palangkaraya. Some miss-information and a bad impression can be felt by children who do not understand about TSE that causes momentary darkness during totality phase. Therefore we designed a children education programs about the TSE that as follow: (1) socialization about TSE, (2) Popular astronomy seminar, (3) How to observe the Sun? (4) writing competition about TSE and (5) TSE observation. The events were held on March 8th - 9th 2016. More than 200 representatives of elementary school students and teachers throughout Palangkaraya have actively participated. The keynote speaker was an Indonesian expert astronomer with help from alumni of astronomy olympiad in order to provide inspiration for the participants, especially to the students. We conclude that students as young generation of the nation may have more motivation to work in science by direct learning from natural phenomena.

  10. All-Terrain Vehicle Safety and Use Patterns in Central Illinois Youth

    Science.gov (United States)

    Hafner, John W.; Hough, Scott M.; Getz, Marjorie A.; Whitehurst, Yvette; Pearl, Richard H.

    2010-01-01

    Context: All-terrain vehicles' (ATVs) popularity and associated injuries among children are increasing in the United States. Currently, most known ATV use pattern data are obtained from injured youth and little documented data exist characterizing the typical ATV use patterns and safety practices among American children in general. Purpose: To…

  11. Supervised Generative Reconstruction: An Efficient Way To Flexibly Store and Recognize Patterns

    CERN Document Server

    Achler, Tsvi

    2011-01-01

    Matching animal-like flexibility in recognition and the ability to quickly incorporate new information remains difficult. Limits are yet to be adequately addressed in neural models and recognition algorithms. This work proposes a configuration for recognition that maintains the same function of conventional algorithms but avoids combinatorial problems. Feedforward recognition algorithms such as classical artificial neural networks and machine learning algorithms are known to be subject to catastrophic interference and forgetting. Modifying or learning new information (associations between patterns and labels) causes loss of previously learned information. I demonstrate using mathematical analysis how supervised generative models, with feedforward and feedback connections, can emulate feedforward algorithms yet avoid catastrophic interference and forgetting. Learned information in generative models is stored in a more intuitive form that represents the fixed points or solutions of the network and moreover disp...

  12. 3D Quaternary deformation pattern in the central Po Plain (Northern Italy)

    Science.gov (United States)

    Sileo, G.; Mueller, K.; Michetti, A. M.; Livio, F.; Berlusconi, A.; Carcano, C.; Rogledi, S.; Vittori, E.

    2009-04-01

    The Po Plain is a foredeep basin flanked by the two major and active orogens of the Italian Peninsula, the Alps to the North and the Apennines to the South. The basin has a quasi - triangular shape and grades longitudinally to the East in the Adriatic Sea. We used petroleum industry seismic reflection data acquired by ENI E&P in the Central Po Plain, over an area spanning about 6800 km2 from Lake Como to the W to Lake Garda to the E, and from the Lombardian Southern Alps to the N and the Emilia Apennines to the S, in order to analyze and interpret selected seismic reflectors and to define the evolution in space and time of the local active tectonic structures. Folds associated with underlying thrusts were recognized based on deformation recorded by two regional sequence boundary horizons, i.e. the ‘A' Surface (1.6 Myr) and the ‘R' Surface (0. 9 Myr; e.g., Carcano & Piccin, 2002; Muttoni et al., 2003), characterized by good stratigraphic and age bracketing, and marking significant changes in the sedimentary architecture of the Po Basin. Age controls are based on stratigraphic, paleontological and magnetostratigraphic analysis by ENI E&P and Regione Lombardia (Carcano & Piccin, 2002; Scardia et al., 2006). The analysis of strain recorded by these horizons allowed us to: A) recognize a belt of active fold and thrust structures, each 10 to 20 km long, arranged with an en-echelon pattern across the whole Po Basin, and B) analyze their evolution over the Quaternary. 'A' surface (1.6 Myr) The ‘A' surface has been mapped over about 7800 Km2. From North to South four major morphobathymetric domains can be defined in the Pleistocene marine Po Basin: an Alpine platform domain, a slope that links it with the wider central basin domain, a smaller and steeper slope and an Apennine platform domain. The basin shape has an asymmetric transversal profile and is ca. 40 km wide. Several tectonic structures affect this surface. On the Alpine platform domain two small structures

  13. Endogenous rhythm and pattern-generating circuit interactions in cockroach motor centres

    Directory of Open Access Journals (Sweden)

    Izhak David

    2016-09-01

    Full Text Available Cockroaches are rapid and stable runners whose gaits emerge from the intricate, and not fully resolved, interplay between endogenous oscillatory pattern-generating networks and sensory feedback that shapes their rhythmic output. Here we studied the endogenous motor output of a brainless, deafferented preparation. We monitored the pilocarpine-induced rhythmic activity of levator and depressor motor neurons in the mesothoracic and metathoracic segments in order to reveal the oscillatory networks’ architecture and interactions. Data analyses included phase relations, latencies between and overlaps of rhythmic bursts, spike frequencies, and the dependence of these parameters on cycle frequency. We found that, overall, ipsilateral connections are stronger than contralateral ones. Our findings revealed asymmetries in connectivity among the different ganglia, in which meta-to-mesothoracic ascending coupling is stronger than meso-to-metathoracic descending coupling. Within-ganglion coupling between the metathoracic hemiganglia is stronger than that in the mesothoracic ganglion. We also report differences in the role and mode of operation of homologue network units (manifested by levator and depressor nerve activity. Many observed characteristics are similar to those exhibited by intact animals, suggesting a dominant role for feedforward control in cockroach locomotion. Based on these data we posit a connectivity scheme among components of the locomotion pattern generating system.

  14. Low frequency variability of European weather patterns and its impact on power generation in northern Europe

    Science.gov (United States)

    Masato, Giacomo; Slavov, Georgi

    2016-04-01

    It is well known that Europe is becoming increasingly reliant on the power generation from the solar and wind sources. Germany is a leader in such a trend - it is then interesting to study to what extent the low-frequency variability of the European weather patterns impacts the power production in this country. Rather than identifying such patterns starting from the weather angle, four weather regimes are identified that maximize and minimize the production of solar and wind power. The analysis of their past occurrence and trends allows us to estimate the potential amount of energy produced for any given year (assuming a constant installed capacity). It is found that the sole change in such weather regimes over the recent years is able to drive up to a 20% annual difference in power generation. This also throws an interesting challenge at the scientific community, whereby the future projection of these regimes can heavily influence both the short- and long-term Eurozone plans in terms of European renewable energy targets.

  15. The repair of an electric generator at the Patla hydro central; Reparacion de un generador de la central hidroelectrica de Patla

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez Hernandez, Roman [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    This document describes the repair of the Generator Number 1 of the system of the Unit No. 1 of the Patla Hydro Power Central in Mexico. The tests that were conducted to determine the fault and the location of the same are shown. Mention is made of the fault repair options and the stages in one of the options are described, since it is the one that better covers the expectations for the satisfactory repair of the generator. Finally the commissioning test is described and it is concluded that an increment of 92% (14 MW) in the generation capacity of the unit was achieved, being this the first time a repair of this type is made of generating units [Espanol] Este documento describe la reparacion del generador numero 1 del sistema de la unidad numero 1 de la central hidroelectrica de Patla en Mexico. Se muestran las pruebas que se hicieron para determinar la falla y localizacion de la misma. Se mencionan las alternativas de reparacion de la falla y se describen las etapas de una de las alternativas, ya que es la que cubre mejor las expectativas para la reparacion satisfactoria del generador. Por ultimo se describe la prueba de puesta en servicio y se concluye en que se logro un aumento de la capacidad de generacion de la unidad en un 92% (14 MW), siendo la primera vez que se hace una reparacion de este tipo de unidades generadoras

  16. Contribution of persistent sodium current to locomotor pattern generation in neonatal rats.

    Science.gov (United States)

    Tazerart, Sabrina; Viemari, Jean-Charles; Darbon, Pascal; Vinay, Laurent; Brocard, Frédéric

    2007-08-01

    The persistent sodium current (I(NaP)) is known to play a role in rhythm generation in different systems. Here, we investigated its contribution to locomotor pattern generation in the neonatal rat spinal cord. The locomotor network is mainly located in the ventromedial gray matter of upper lumbar segments. By means of whole cell recordings in slices, we characterized membrane and I(NaP) biophysical properties of interneurons located in this area. Compared with motoneurons, interneurons were more excitable, because of higher input resistance and membrane time constant, and displayed lower firing frequency arising from broader spikes and longer AHPs. Ramp voltage-clamp protocols revealed a riluzole- or TTX-sensitive inward current, presumably I(NaP), three times smaller in interneurons than in motoneurons. However, in contrast to motoneurons, I(NaP) mediated a prolonged plateau potential in interneurons after reducing K(+) and Ca(2+) currents. We further used in vitro isolated spinal cord preparations to investigate the contribution of I(NaP) to locomotor pattern. Application of riluzole (10 muM) to the whole spinal cord or to the upper lumbar segments disturbed fictive locomotion, whereas application of riluzole over the caudal lumbar segments had no effect. The effects of riluzole appeared to arise from a specific blockade of I(NaP) because action potential waveform, dorsal root-evoked potentials, and miniature excitatory postsynaptic currents were not affected. This study provides new functional features of ventromedial interneurons, with the first description of I(NaP)-mediated plateau potentials, and new insights into the operation of the locomotor network with a critical implication of I(NaP) in stabilizing the locomotor pattern.

  17. Controlling the magnetic field distribution on the micrometer scale and generation of magnetic bead patterns for microfluidic applications.

    Science.gov (United States)

    Yu, Xu; Feng, Xuan; Hu, Jun; Zhang, Zhi-Ling; Pang, Dai-Wen

    2011-04-19

    As is well known, controlling the local magnetic field distribution on the micrometer scale in a microfluidic chip is significant and has many applications in bioanalysis based on magnetic beads. However, it is a challenge to tailor the magnetic field introduced by external permanent magnets or electromagnets on the micrometer scale. Here, we demonstrated a simple approach to controlling the local magnetic field distribution on the micrometer scale in a microfluidic chip by nickel patterns encapsulated in a thin poly(dimethylsiloxane) (PDMS) film under the fluid channel. With the precisely controlled magnetic field, magnetic bead patterns were convenient to generate. Moreover, two kinds of fluorescent magnetic beads were patterned in the microfluidic channel, which demonstrated that it was possible to generate different functional magnetic bead patterns in situ, and could be used for the detection of multiple targets. In addition, this method was applied to generate cancer cell patterns.

  18. Patterns and drivers of phytodiversity in steppe grasslands of Central Podolia (Ukraine)

    DEFF Research Database (Denmark)

    Kuzemko, Anna; Steinbauer, Manuel; Becker, Thomas;

    2016-01-01

    nested-plot series ranging from 0.0001 to 100 m2 and additional 10-m2 plots, covering different vegetation types and management regimes in steppes and semi-natural dry grasslands of Central Podolia (Ukraine). We recorded all terricolous taxa and used topographic, soil, land-use and climatic variables...

  19. Railway station, centres and markets: Change and stability in patterns of urban centrality

    NARCIS (Netherlands)

    Kusumo, C.

    2007-01-01

    Railway stations have become hubs of networks due to their high accessibility by different modes of transport at different scale levels and have emerged as potential new central places in metropolitan cities in Europe. Planners and designers put a lot of effort into transforming these railway statio

  20. Optimisation of a Kalina cycle for a central receiver solar thermal power plant with direct steam generation

    DEFF Research Database (Denmark)

    Modi, Anish; Haglind, Fredrik

    2014-01-01

    Central receiver solar thermal power plants are regarded as one of the promising ways to generate electricity in near future. They offer the possibility of using high temperatures and pressures to achieve high efficiencies with standard power cycles. A direct steam generation approach can be used...... for a central receiver solar thermal power plant with direct steam generation. The variation in the cycle performance with respect to the turbine inlet ammonia mass fraction and pressure and a comparison of the initial investment with that of the basic Rankine cycle are also presented. Only high live steam...... for such plants for improved performance. This approach can also be combined with using advanced power cycles like the Kalina cycle, which uses a zeotropic mixture of ammonia and water instead of pure water as the working fluid. This paper presents the optimisation of a particular Kalina cycle layout...

  1. Coupling of upper and lower limb pattern generators during human crawling at different arm/leg speed combinations.

    Science.gov (United States)

    MacLellan, M J; Ivanenko, Y P; Catavitello, G; La Scaleia, V; Lacquaniti, F

    2013-03-01

    A crawling paradigm was performed by healthy adults to examine inter-limb coupling patterns and to understand how central pattern generators (CPGs) for the upper and lower limbs are coordinated. Ten participants performed hands-and-feet crawling on two separate treadmills, one for the upper limbs and another one for the lower limbs, the speed of each of them being changed independently. A 1:1 frequency relationship was often maintained even when the treadmill speed was not matched between the upper and lower limbs. However, relative stance durations in the upper limbs were only affected by changes of the upper limb treadmill speed, suggesting that although absolute times are adjusted, the relative proportions of stances and swing do not adapt to changes in lower limb treadmill speeds. With large differences between treadmill speeds, changes in upper and lower limb coupling ratio tended to occur when the upper limbs stepped at slower speeds than the lower limbs, but more rarely the other way around. These findings are in sharp contrast with those in the cat, where forelimbs always follow the rhythm of the faster moving hindlimbs. However, the fact that an integer frequency ratio is often maintained between the upper and lower limbs supports evidence of coupled CPG control. We speculate that the preference for the upper limb to decrease step frequency at lower speeds in humans may be due to weaker ascending propriospinal connections and/or a larger influence of cortical control on the upper limbs which allows for an overriding of spinal CPG control.

  2. Practice patterns among thyroid cancer surgeons: implications of performing a prophylactic central neck dissection

    OpenAIRE

    Deutschmann, Michael W.; Chin-Lenn, Laura; Nakoneshny, Steven C.; Dort, Joseph C.; Pasieka, Janice L.; Chandarana, Shamir P.

    2016-01-01

    Background Indications for performing a prophylactic central neck dissection (pCND) in papillary thyroid cancer (PTC) remain controversial. It is unclear how identification of lymph node (LN) metastases should impact the decision to treat with radioactive iodine (RAI). The goals of this study were to identify indications for performing pCND and identify factors that predict the use of adjuvant RAI. Methods This was a population based cross-sectional analysis. A prospectively collected databas...

  3. Central Cell-Derived Peptides Regulate Early Embryo Patterning in Flowering Plants

    NARCIS (Netherlands)

    Costa, L.M.; Marshall, E.; Tesfaye, M.; Silverstein, K.A.T.; Mori, M.; Umetsu, Y.; Otterbach, S.L.; Papareddy, R.; Dickinson, H.G.; Boutilier, K.A.; VandenBosch, K.A.; Ohki, S.; Gutierrez-Marcos, J.F.

    2014-01-01

    Plant embryogenesis initiates with the establishment of an apical-basal axis; however, the molecular mechanisms accompanying this early event remain unclear. Here, we show that a small cysteine-rich peptide family is required for formation of the zygotic basal cell lineage and proembryo patterning i

  4. Evidence of involvement of central neural mechanisms in generating fibromyalgia pain.

    Science.gov (United States)

    Staud, Roland

    2002-08-01

    Fibromyalgia syndrome (FMS) is characterized by widespread pain, fatigue, sleep abnormalities, and distress. Because FMS lacks consistent evidence of tissue abnormalities, recent investigations have focused on central nervous system mechanisms of pain. Abnormal temporal summation of second pain (wind-up) and central sensitization have been described recently in patients with FMS. Wind-up and central sensitization, which rely on central pain mechanisms, occur after prolonged C-nociceptor input and depend on activation of nociceptor-specific neurons and wide dynamic range neurons in the dorsal horn of the spinal cord. Other abnormal central pain mechanisms recently detected in patients with FMS include diffuse noxious inhibitory controls. These pain inhibitory mechanisms rely on spinal cord and supraspinal systems involving pain facilitatory and pain inhibitory pathways. Brain-imaging techniques that can detect neuronal activation after nociceptive stimuli have provided additional evidence for abnormal central pain mechanisms in FMS. Brain images have corroborated the augmented reported pain experience of patients with fibromyalgia during experimental pain stimuli. In addition, thalamic activity, which contributes significantly to pain processing, was decreased in fibromyalgia. However, central pain mechanisms of fibromyalgia may not depend exclusively on neuronal activation. Neuroglial activation has been found to play an important role in the induction and maintenance of chronic pain. These findings may have important implications for future research and the treatment of fibromyalgia pain.

  5. Optimum projection pattern generation for grey-level coded structured light illumination systems

    Science.gov (United States)

    Porras-Aguilar, Rosario; Falaggis, Konstantinos; Ramos-Garcia, Ruben

    2017-04-01

    Structured light illumination (SLI) systems are well-established optical inspection techniques for noncontact 3D surface measurements. A common technique is multi-frequency sinusoidal SLI that obtains the phase map at various fringe periods in order to estimate the absolute phase, and hence, the 3D surface information. Nevertheless, multi-frequency SLI systems employ multiple measurement planes (e.g. four phase shifted frames) to obtain the phase at a given fringe period. It is therefore an age old challenge to obtain the absolute surface information using fewer measurement frames. Grey level (GL) coding techniques have been developed as an attempt to reduce the number of planes needed, because a spatio-temporal GL sequence employing p discrete grey-levels and m frames has the potential to unwrap up to pm fringes. Nevertheless, one major disadvantage of GL based SLI techniques is that there are often errors near the border of each stripe, because an ideal stepwise intensity change cannot be measured. If the step-change in intensity is a single discrete grey-level unit, this problem can usually be overcome by applying an appropriate threshold. However, severe errors occur if the intensity change at the border of the stripe exceeds several discrete grey-level units. In this work, an optimum GL based technique is presented that generates a series of projection patterns with a minimal gradient in the intensity. It is shown that when using this technique, the errors near the border of the stripes can be significantly reduced. This improvement is achieved with the choice generated patterns, and does not involve additional hardware or special post-processing techniques. The performance of that method is validated using both simulations and experiments. The reported technique is generic, works with an arbitrary number of frames, and can employ an arbitrary number of grey-levels.

  6. Energy Pattern Generator; Understanding the effect of user behaviour on energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Paauw, J.; Roossien, B. [ECN Efficiency and Infrastructure, Petten (Netherlands); Aries, M.B.C. [TNO Built Environment and Geosciences, Delft (Netherlands); Guerra Santin, O. [OTB Research Institute for Housing, Urban and Mobility Studies, Delft University of Technology, Delft (Netherlands)

    2009-11-15

    To understand and research the effect of user behaviour on energy performance, an Energy Pattern Generator (EPG) is being developed. This software tool produces high resolution electricity and heat demand patterns for five different household types. In addition, energy consumption is related to five common types of dwellings in the Netherlands. Input for the EPG is provided by measured energy demand profiles of common household appliances and statistical data from time-of-use surveys. Internal heat gains due to appliances play an important role in the energy balance of energy efficient buildings. These gains are however often simplified in today's tools into (at best) fixed weekly schedules. The EPG provides a more realistic representation of (the variation in) occupant behaviour. Varying internal gains are calculated for several user profiles, based on variations in the use of domestic appliances and the household occupancy by the residents. Using the EPG as a 'plug-in', building simulation can determine whether new building concepts are 'user proof'. The EPG is also of importance in the design of (intelligent) electricity grids as it provides dynamics in the grid's loads. The EPG provides insight in actual loads which can be scaled up to i.e. district level.

  7. Technological solutions of decentralized generation of hydroelectricity for those demands that cannot be attended by conventional electric with centralized generation

    Energy Technology Data Exchange (ETDEWEB)

    Signoretti, Valdir Tesche; Veras, Carlos Alberto Gurgel Rudi; Els, Henri Van [Universidade de Brasilia, Brasilia, DF (Brazil). Faculdade de Tecnologia. Dept. de Engenharia Mecanica], e-mail: gurgel@unb.br

    2010-07-01

    A source of energy stable and reliable and of acceptable cost is a basic requisite for the development of a given region can give-if full. Access to energy is important basis of human existence, essential to the satisfaction of basic needs such as food, clothing, and housing and also of mobility and communication. However, the dependency world burning of fossil fuels for energy generation and supply of a demand constantly increasing, both in industrialized countries and those in development, already threatening the ecological stability of the Earth. At the same time, conflicts by distribution of the last reserves these resources non-renewable threaten significantly to civil society. Adding to the breakneck speed in which humanity consumes the energetic sources and the obvious devastation of nature has an unequal distribution in consumption and access to energy. Renewable sources and energy efficiency are viable and necessary, especially because they can be the key to reduce wastefulness and extend the access to energy. In this way, there is a significant influence on economic and social inclusion of population excluded, generating employment and income with costs local and global environmental reduced compared to traditional forms and unsustainable generation and use of energy. This work is a study involving issues related to rural electrification from hydroelectricity, especially related to those isolated communities of the Amazon region that are lacking this form of energy, presented a general review since the origins of hydroelectricity in Brazil, as well as a national panorama electric exclusion as well as a scenario Amazon's supply of electricity. Finally presenting-if the main technologies available for hydroelectric generation for these isolated communities. (author)

  8. Dynamic contrast enhancement in widefield microscopy using projector-generated illumination patterns

    Science.gov (United States)

    Carlo Samson, Edward; Mar Blanca, Carlo

    2007-10-01

    We present a simple and cost-effective optical protocol to realize contrast-enhancement imaging (such as dark-field, optical-staining and oblique illumination microscopy) of transparent samples on a conventional widefield microscope using commercial multimedia projectors. The projector functions as both light source and mask generator implemented by creating slideshows of the filters projected along the illumination planes of the microscope. The projected optical masks spatially modulate the distribution of the incident light to selectively enhance structures within the sample according to spatial frequency thereby increasing the image contrast of translucent biological specimens. Any amplitude filter can be customized and dynamically controlled so that switching from one imaging modality to another involves a simple slide transition and can be executed at a keystroke with no physical filters and no moving optical parts. The method yields an image contrast of 89 96% comparable with standard enhancement techniques. The polarization properties of the projector are then utilized to discriminate birefringent and non-birefringent sites on the sample using single-shot, simultaneous polarization and optical-staining microscopy. In addition to dynamic pattern generation and polarization, the projector also provides high illumination power and spectral excitation selectivity through its red-green-blue (RGB) channels. We exploit this last property to explore the feasibility of using video projectors to selectively excite stained samples and perform fluorescence imaging in tandem with reflectance and polarization reflectance microscopy.

  9. Fabrication and applications of orientation-patterned gallium arsenide for mid-infrared generation

    Energy Technology Data Exchange (ETDEWEB)

    Grisard, A.; Gutty, F.; Lallier, E. [Thales Research and Technology France, 1 av. Augustin Fresnel, 91767 Palaiseau Cedex (France); Gerard, B. [III-V Lab, 1 av. Augustin Fresnel, 91767 Palaiseau Cedex (France); Jimenez, J. [GdS Optronlab, Fisica Materia Condensada, Universidad de Valladolid, 47011 Valladolid (Spain)

    2012-07-15

    Nonlinear optical materials play a key role in the development of coherent sources of radiation, by frequency conversion of light from other light sources, e.g. diode, solid-state, and fiber lasers, into spectral ranges where few lasers exist or perform poorly. Based on the principle of the quasi-phase matching, the design and fabrication of orientation-patterned Gallium Arsenide crystals (OP-GaAs) has recently led to demonstrations of second harmonic generation, optical parametric generation, amplification and oscillation from 1 to 12 {mu}m. The most efficient fabrication route for these crystals relies on the use of the near-equilibrium growth process HVPE (Hydride Vapour Phase Epitaxy), by orientation-selective regrowth on OP-GaAs template wafers with a thickness suited to bulk nonlinear optics. This work deals with recent characterizations based on optical experiments and cathodoluminescence measurements, targeting the identification of the main defects, their spatial distribution, and their relation to the optical propagation losses. Latest improvements of the HVPE growth step have enabled to reach an unprecedented level of losses, below 0.016 cm{sup -1}, and a large range of available QPM periods and thickness of structures (copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  10. BEYOND GUNS AND BUTTER: Finnish Central Government Spending Patterns the in Twentieth Century

    Directory of Open Access Journals (Sweden)

    Jari Eloranta

    2008-01-01

    Full Text Available This paper explains the long-run demand for central government spending in Finland by analyzing quantitative and qualitative changes in the spending behavior, examining possible links between variables in a VAR-framework, and performing multivariate analysis of the demand factors. The results was shoved that a explained  by a lack of military versus social spending tradeoff effect. Even though certain other variables were found to be relevant in explaining this demand, this lack of a tradeoff increased the Finnish spending levels substantially during the twentieth centurt welfare state expansion.

  11. Pattern of Colon Cancer Lymph Node Metastases in Patients Undergoing Central Mesocolic Lymph Node Excision

    DEFF Research Database (Denmark)

    Bertelsen, Claus A; Kirkegaard-Klitbo, Anders; Nielsen, Ming-Yuan

    2016-01-01

    of definitions of lymph node location, tumor sites, stage, morphology, pathology assessment, and inclusion criteria (selection bias), of the included studies were limitations. Also, anatomic definitions were not uniform. CONCLUSIONS: The present literature cannot give a theoretical explanation of a better...... excluded. MAIN OUTCOME MEASURES: The risk of metastases in the central mesocolic lymph nodes was measured. RESULTS: A total of 2052 articles were screened, of which 277 underwent full-text review. The 47 studies fulfilling the inclusion criteria were very heterogeneous, and meta-analyses were...

  12. Altitudinal Pattern of Plant Species Diversity in Shennongjia Mountains, Central China

    Institute of Scientific and Technical Information of China (English)

    Chang-Ming ZHAO; Wei-Lie CHEN; Zi-Qiang TIAN; Zong-Qiang XIE

    2005-01-01

    One hundred and sixty plots, approximately every 100 m above sea level (a.s.l.) along an altitudinal gradient from 470 to 3 080 m a.s.l, at the southern and northern watershed of Mt. Shennongjia,China, were examined to determine the altitudinal pattern of plant species diversity. Mt. Shennongjia was found to have high plant species diversity, with 3 479 higher plants recorded. Partial correlation analysis and detrended canonical correspondence analysis (DCCA) based on plant species diversity revealed that altitude was the main factor affecting the spatial pattern of plant species diversity on Mt. Shennongjia and that canopy coverage of the arbor layer also had a considerable effect on plant species diversity. The DCCA based on species data of importance value further revealed that altitude gradient was the primary factor shaping the spatial pattern of plant species. In addition, the rule of the "mid-altitude bulge" was supported on Mt. Shennongjia. Plant species diversity was closely related to vegetation type and the transition zone usually had a higher diversity. Higher plant species diversity appeared in the mixed evergreen and deciduous broadleaved forest zone (900-1 500 m a.s.l.) and its transition down to evergreen broadleaved forest zone or up to deciduous broadleaved forest zone. The largest plant species diversity in whole communities on Mt. Shennongjia lay at approximately 1 200 m a.s.l. Greatest tree diversity, shrub diversity, and grass diversity was found at approximately 1 500, 1 100, and 1 200 m a.s.l., respectively. The southern watershed showed higher plant species diversity than the northern watershed, with maximum plant species diversity at a higher altitude in the southern watershed than the northern watershed. These results indicate that Mt.Shennongjia shows characteristics of a transition region. The relationship between the altitudinal pattern of plant species diversity and the vegetation type in eastern China are also discussed and a

  13. Mosquito biodiversity patterns around urban environments in South-central okinawa island, Japan.

    Science.gov (United States)

    Hoshi, Tomonori; Imanishi, Nozomi; Higa, Yukiko; Chaves, Luis Fernando

    2014-12-01

    Okinawa is the largest, most urbanized, and densely populated island in the Ryukyus Archipelago, where mosquito species diversity has been thoroughly studied. However, the south-central Okinawa mosquito fauna has been relatively poorly studied. Here, we present results from a mosquito faunal survey in urban environments of Nishihara city, south-central Okinawa. Mosquitoes were sampled biweekly, from April 2007 to March 2008, at 3 different environments: a forest preserve, an animal farm, and a water reservoir. We employed 4 mosquito collection methods: 1) oviposition traps; 2) light traps; 3) sweep nets; and 4) larval surveys of tree holes, leaf axils, and artificial water containers. We collected a total of 568 adults and 10,270 larvae belonging to 6 genera and 13 species, including 6 species of medical importance: Aedes albopictus, Armigeres subalbatus, Anopheles Hyrcanus group, Culex bitaeniorhynchus, Cx. quinquefasciatus, and Cx. tritaeniorhynchus. Mosquito species composition was similar to data from previous studies in Okinawa Island. The flattening of the species accumulation curve suggests that our diversity sampling was exhaustive with light and oviposition traps, as well as the coincidence between the species richness we found in the field and estimates from the Chao2 index, a theoretical estimator of species richness based on species abundance. This study highlights the importance of combining several sampling techniques to properly characterize regional mosquito fauna and to monitor changes in the presence of mosquito species.

  14. Pattern of Maxillofacial fracture in Western and Central Nepal: An experience in 3 tertiary level health institutions

    Directory of Open Access Journals (Sweden)

    S Subedi

    2015-06-01

    Full Text Available BACKGROUND: There are only few studies regarding the pattern and causes of maxillofacial fractures till date in Nepal and no such study in western and central Nepalese population has been conducted. The purpose of this study, therefore, was to describe the causes and the pattern of maxillofacial fractures in western and central part of Nepal over the period of 5 years. MATERIAL AND METHODS A retrospective analysis of maxillofacial fractures was conducted on 328 patients who were treated in the department of maxillofacial surgery. Data was extracted and analyzed based on age, sex, cause of injury and anatomic location. RESULT Young males of 3rd decade of life most commonly sustained the maxillofacial trauma. The commonest site involved was the zygomatic complex (42% when only mid face fractures was considered and parasymphysis (32% when only mandible was considered.The most common cause of injuries was road traffic accidents (289 patients; 88.1% followed by interpersonal violence (25 patients; 7.6 % and falls accounting for 4.2% of the all injuries. CONCLUSION The findings of this study suggest the need for expansion of the motorway network, ensuring compliance of strict traffic rules and regulations, replacing old vehicles without safety measures and implement school education in alcohol abuse.DOI: http://dx.doi.org/10.3126/jcmsn.v10i3.12771 Journal of College of Medical Sciences-Nepal, 2014, Vol-10, No-3, 8-13

  15. Burden & pattern of illnesses among the tribal communities in central India : A report from a community health programme.

    Science.gov (United States)

    Jain, Yogesh; Kataria, Raman; Patil, Sushil; Kadam, Suhas; Kataria, Anju; Jain, Rachna; Kurbude, Ravindra; Shinde, Sharayu

    2015-05-01

    Tribals are the most marginalised social category in the country and there is little and scattered information on the actual burden and pattern of illnesses they suffer from. This study provides information on burden and pattern of diseases among tribals, and whether these can be linked to their nutritional status, especially in particularly vulnerable tribal groups (PVTG) seen at a community health programme being run in the tribal areas of Chhattisgarh and Madhya Pradesh States of India. This community based programme, known as Jan Swasthya Sahyog (JSS) has been serving people in over 2500 villages in rural central India. It was found that the tribals had significantly higher proportion of all tuberculosis, sputum positive tuberculosis, severe hypertension, illnesses that require major surgery as a primary therapeutic intervention and cancers than non tribals. The proportions of people with rheumatic heart disease, sickle cell disease and epilepsy were not significantly different between different social groups. Nutritional levels of tribals were poor. Tribals in central India suffer a disproportionate burden of both communicable and non communicable diseases amidst worrisome levels of undernutrition. There is a need for universal health coverage with preferential care for the tribals, especially those belonging to the PVTG. Further, the high level of undernutrition demands a more augmented and universal Public Distribution System.

  16. Association between atmospheric circulation patterns and firn-ice core records from the Inilchek glacierized area, central Tien Shan, Asia

    Science.gov (United States)

    Aizen, V.B.; Aizen, E.M.; Melack, J.M.; Kreutz, K.J.; Cecil, L.D.

    2004-01-01

    Glacioclimatological research in the central Tien Shan was performed in the summers of 1998 and 1999 on the South Inilchek Glacier at 5100-5460 m. A 14.36 m firn-ice core and snow samples were collected and used for stratigraphic, isotopic, and chemical analyses. The firn-ice core and snow records were related to snow pit measurements at an event scale and to meteorological data and synoptic indices of atmospheric circulation at annual and seasonal scales. Linear relationships between the seasonal air temperature and seasonal isotopic composition in accumulated precipitation were established. Changes in the ??18O air temperature relationship, in major ion concentration and in the ratios between chemical species, were used to identify different sources of moisture and investigate changes in atmospheric circulation patterns. Precipitation over the central Tien Shan is characterized by the lowest ionic content among the Tien Shan glaciers and indicates its mainly marine origin. In seasons of minimum precipitation, autumn and winter, water vapor was derived from the and and semiarid regions in central Eurasia and contributed annual maximal solute content to snow accumulation in Tien Shan. The lowest content of major ions was observed in spring and summer layers, which represent maximum seasonal accumulation when moisture originates over the Atlantic Ocean and Mediterranean and Black Seas. Copyright 2004 by the American Geophysical Union.

  17. Marketing patterns of agricultural commodities in an upland area of Central Java

    Directory of Open Access Journals (Sweden)

    Caroline M. van Ommeren

    2013-07-01

    Full Text Available In the uplands of Central Java a wide variety of dry cultivated crops are produced for subsistence as well as for cash. The marketing channels for these crops are also diverse. The producers can choose between selling at the market place or at their farms; either to consumers or traders; or they can sell their products to wholesalers in the towns. However, this freedom of choice is not absolute and is determined by the quantity of the merchandise. Farmers/who can sell large amounts of produce are able to bypass some steps in the hierarchical order of market places or traders. Thus, producers with relatively large farmlands can sell their commodities in more profitable ways compared to those with /smaller farms. Moreover, the latter are often forced to sell their produce below market value to traders who provided them with advance or who bought the crop before harvest (tebasan, because of their need for cash

  18. Modeling patterns of coral bleaching at a remote Central Pacific atoll.

    Science.gov (United States)

    Williams, Gareth J; Knapp, Ingrid S; Maragos, James E; Davy, Simon K

    2010-09-01

    A mild bleaching event (9.2% prevalence) at Palmyra Atoll occurred in response to the 2009 ENSO, when mean water temperature reached 29.8-30.1 degrees C. Prevalence among both abundant and sparse taxa varied with no clear pattern in susceptibility relating to coral morphology. Seven taxon-specific models showed that turbidity exacerbated while prior exposure to higher background temperatures alleviated bleaching, with these predictors explaining an average 16.3% and 11.5% variation in prevalence patterns, respectively. Positive associations occurred between bleaching prevalence and both immediate temperature during the bleaching event (average 8.4% variation explained) and increased sand cover (average 3.7%). Despite these associations, mean unexplained variation in prevalence equalled 59%. Lower bleaching prevalence in areas experiencing higher background temperatures suggests acclimation to temperature stress among several coral genera, while WWII modifications may still be impacting the reefs via shoreline sediment re-distribution and increased turbidity, exacerbating coral bleaching susceptibility during periods of high temperature stress.

  19. Habitat use and foraging patterns of molting male Long-tailed Ducks in lagoons of the central Beaufort Sea, Alaska

    Science.gov (United States)

    Flint, Paul L.; Reed, John; Deborah Lacroix,; Richard Lanctot,

    2016-01-01

    From mid-July through September, 10 000 to 30 000 Long-tailed Ducks (Clangula hyemalis) use the lagoon systems of the central Beaufort Sea for remigial molt. Little is known about their foraging behavior and patterns of habitat use during this flightless period. We used radio transmitters to track male Long-tailed Ducks through the molt period from 2000 to 2002 in three lagoons: one adjacent to industrial oil field development and activity and two in areas without industrial activity. We found that an index to time spent foraging generally increased through the molt period. Foraging, habitat use, and home range size showed similar patterns, but those patterns were highly variable among lagoons and across years. Even with continuous daylight during the study period, birds tended to use offshore areas during the day for feeding and roosted in protected nearshore waters at night. We suspect that variability in behaviors associated with foraging, habitat use, and home range size are likely influenced by availability of invertebrate prey. Proximity to oil field activity did not appear to affect foraging behaviors of molting Long-tailed Ducks.

  20. Patterns of fish community composition along a river affected by agricultural and urban disturbance in south-central Chile

    Energy Technology Data Exchange (ETDEWEB)

    Orrego, Rodrigo [University of Ontario Institute of Technology, Oshawa, Ontario; Barra, Ricardo [University of Concepcion, Eula, Chile; Chiang, Gustavo [University of Concepcion, Eula, Chile; Adams, Marshall [ORNL; Gavilan, Juan F. [University of Concepcion, Eula, Chile

    2008-03-01

    Patterns of fish community composition in a south-central Chile river were investigated along the altitudinal-spatial and environmental gradient and as a function of anthropogenic factors. The spatial pattern of fish communities in different biocoenotic zones of the Chillan River is influenced by both natural factors such a hydrologic features, habitat, and feeding types, and also by water quality variables which can reduce the diversity and abundance of sensitive species. A principal component analysis incorporating both water quality parameters and biomarker responses of representative fish species was used to evaluate the status of fish communities along the spatial gradient of the stream. The abundance and diversity of the fish community changed from a low in the upper reaches where the low pollution-tolerant species such as salmonid dominated, to a reduced diversity in the lower reaches of the river where tolerant browser species such as cypriniformes dominated. Even though the spatial pattern of fish community structure is similar to that found for the Chilean Rivers, the structure of these communities is highly influenced by human disturbance, particularly along the lower reaches of the river.

  1. Temporal patterns and geographic heterogeneity of Zika virus (ZIKV) outbreaks in French Polynesia and Central America

    Science.gov (United States)

    2017-01-01

    Background Zika virus (ZIKV) transmission has been reported in 67 countries/territories in the Oceania region and the Americas since 2015, prompting the World Health Organization (WHO) to declare ZIKV as a Public Health Emergency of International Concern in February 2016, due to its strong association with medical complications such as microcephaly and Guillain–Barré Syndrome (GBS). However, a substantial gap in knowledge still exists regarding differing temporal pattern and potential of transmission of ZIKV in different regions of the world. Methods We use a phenomenological model to ascertain the temporal patterns and transmission potential of ZIKV in various countries/territories, by fitting the model to Zika case data from Yap Island and French Polynesia in the Oceania region and 11 countries/territories with confirmed case data, namely, Colombia, Ecuador, French Guiana, Guadeloupe, Guatemala, Mexico, Nicaragua, Panama, Puerto Rico, Saint Martin, and Suriname, to pinpoint the waves of infections in each country/territory and to estimate the respective basic reproduction number R0. Results Six of these time series datasets resulted in statistically significant model fit of at least one wave of reported cases, namely that of French Polynesia, Colombia, Puerto Rico, Guatemala, Suriname and Saint Martin. However, only Colombia and Guatemala exhibited two waves of cases while the others had only one wave. Temporal patterns of the second wave in Colombia and the single wave in Suriname are very similar, with the respective turning points separated by merely a week. Moreover, the mean estimates of R0 for Colombia, Guatemala and Suriname, all land-based populations, range between 1.05 and 1.75, while the corresponding mean estimates for R0 of island populations in French Polynesia, Puerto Rico and Saint Martin are significantly lower with a range of 5.70–6.89. We also fit the Richards model to Zika case data from six main archipelagos in French Polynesia

  2. Temporal patterns and geographic heterogeneity of Zika virus (ZIKV outbreaks in French Polynesia and Central America

    Directory of Open Access Journals (Sweden)

    Ying-Hen Hsieh

    2017-03-01

    Full Text Available Background Zika virus (ZIKV transmission has been reported in 67 countries/territories in the Oceania region and the Americas since 2015, prompting the World Health Organization (WHO to declare ZIKV as a Public Health Emergency of International Concern in February 2016, due to its strong association with medical complications such as microcephaly and Guillain–Barré Syndrome (GBS. However, a substantial gap in knowledge still exists regarding differing temporal pattern and potential of transmission of ZIKV in different regions of the world. Methods We use a phenomenological model to ascertain the temporal patterns and transmission potential of ZIKV in various countries/territories, by fitting the model to Zika case data from Yap Island and French Polynesia in the Oceania region and 11 countries/territories with confirmed case data, namely, Colombia, Ecuador, French Guiana, Guadeloupe, Guatemala, Mexico, Nicaragua, Panama, Puerto Rico, Saint Martin, and Suriname, to pinpoint the waves of infections in each country/territory and to estimate the respective basic reproduction number R0. Results Six of these time series datasets resulted in statistically significant model fit of at least one wave of reported cases, namely that of French Polynesia, Colombia, Puerto Rico, Guatemala, Suriname and Saint Martin. However, only Colombia and Guatemala exhibited two waves of cases while the others had only one wave. Temporal patterns of the second wave in Colombia and the single wave in Suriname are very similar, with the respective turning points separated by merely a week. Moreover, the mean estimates of R0 for Colombia, Guatemala and Suriname, all land-based populations, range between 1.05 and 1.75, while the corresponding mean estimates for R0 of island populations in French Polynesia, Puerto Rico and Saint Martin are significantly lower with a range of 5.70–6.89. We also fit the Richards model to Zika case data from six main archipelagos in French

  3. Terrestrial movement patterns of western pond turtles (Actinemys marmorata) in central California

    Science.gov (United States)

    Pilliod, David S.; Welty, Justin L.; Stafford, Robert

    2013-01-01

    We used radio telemetry to track the terrestrial movements and seasonal habitat use patterns of Western Pond Turtles (Actinemys marmorata) near two ponds in the Carrizo Plain Ecological Reserve, California, USA. We captured 93 turtles in September 2005 and, of these, we tagged three males and six females(weighing > 300 g) with external transmitters. Tagged turtles traveled from 255–1,096 m over the 448-day study, and we found none further than 343 m from ponds. All turtles moved away from the ponds as water levels receded in the fall, resulting in periods of terrestrial overwintering ranging from 10–30 weeks (74–202 d). We found no evidence for group migrations as turtles departed ponds over 2–8 week periods, moved in different directions from their ponds, and used different habitats. Turtles overwintered mainly in oak and chaparral vegetation communities, which constituted most of the local vegetation. We found overwintering turtles in a variety of microhabitats, but all turtles were on the surface with their carapace just visible amongst the duff layer. Turtles returned to ponds over several weeks, sometimes months after they refilled with winter rains. In the winter of 2006–2007, no turtles returned to terrestrial overwintering sites used the previous year. Most of the turtles we tracked spent over half of each year on land, demonstrating the importance of terrestrial habitats around these seasonal ponds. This pattern is similar to pond turtles living in streams (overwinter on land), as compared to permanent ponds (turtles often remain in water).

  4. Patterns in the distribution of sponge populations across the central Great Barrier Reef

    Science.gov (United States)

    Wilkinson, Clive R.; Cheshire, Anthony C.

    1989-12-01

    Coral reef sponge populations were surveyed at two spatial scales: different depths and different reef locations across the continental shelf of the central Great Barrier Reef. The surveys were conducted on the forereef slopes of 12 reefs from land-influenced, inner-shelf reefs to those in the oligotrophic waters of the Coral Sea. Few sponges occur in shallow waters and the largest populations are found between 10 and 30 m depth. Sponges are apparently excluded from shallow waters because of excessive turbulence and possibly by high levels of damaging light. Sponge biomass is highest on the innershelf reefs and decreases away from the coast, whereas abundance is generally higher on middle-shelf reefs. There are considerable overlaps in the species composition on middle-, outer-shelf and Coral Sea reefs, but those on inner-shelf reefs are significantly different. The nature and size of sponge populations reflect environmental conditions across the continental shelf. The larger inner-shelf populations probably reflect higher levels of organic and inorganic nutrients and reduced amounts of physical turbulence, whereas sponges on reefs further from shore may be able to resist greater turbulence but appear more sensitive to the effects of fine sediments. These latter populations are smaller, reflecting the reduced availability of organic matter, however, many of these sponges rely on cyanobacterial symbionts to augment nutrition in these clearer, more oligotrophic waters.

  5. Patterns of preweaning diarrhea in piglets on a central California ranch.

    Science.gov (United States)

    Urcelay, S; Hird, D W; Huffman, E M; Parker, K; Farver, T B

    1984-10-01

    To determine risk factors for development of diarrhea in litters of preweaned piglets, data were analyzed from records of 4,397 litters of swine farrowed on a central California ranch 1978-1982. Sixty-four percent of litters were treated for diarrhea. Statistical analysis by multiple logistic regression showed that litters born to young sows (parity less than or equal to 2) were 1.7 times more likely to develop diarrhea before weaning than were litters born to older sows (parity greater than or equal to 3) and that litters born on one end of farrowing barns were 1.3 times more likely to develop diarrhea than were litters born in the other end. The association of diarrhea with other variables--dam breed, sire, gestation group, gestation length, size of litter, number of mummies, runts or stillbirths per litter, farrowing barn of birth or day of the week farrowed--was weak or nonexistent (P greater than 0.01).

  6. Patterns in the distribution of coral communities across the central Great Barrier Reef

    Science.gov (United States)

    Done, T. J.

    1982-10-01

    Despite the pre-eminence of the Great Barrier Reef, there has been little systematic description of its biotic communities, and in particular, of the corals themselves. Only recently have the problems of coral taxonomy been sufficiently resolved to allow a beginning to be made in rectifying this deficiency. The present study describes seventeen assemblages of corals which occupy the major habitat types found in and near the central Great Barrier Reef. The habitats studied range from the wave swept reef flats of Coral Sea atolls to the slopes of small reefs occupying sheltered, muddy conditions near the coast. These, and the array of reefs between, have characteristic suites of coral communities which provide the basis for a classification of reefs into non- Acropora reefs and various Acropora reefs. It is speculated that the faunistic differences are maintained because reefs are primarily self-seeded and because the majority of larvae from external sources are of species which are already present. The greatest diversity of both species and community types was found on reefs near the middle of the continental shelf, while the oceanic atolls and nearshore silt-affected reefs are almost equally depauperate.

  7. Concept and analytical basis for revistas - A fast, flexible computer/graphic system for generating periodic satellite coverage patterns

    Science.gov (United States)

    King, J. C.

    1976-01-01

    The generation of satellite coverage patterns is facilitated by three basic strategies: use of a simplified physical model, permitting rapid closed-form calculation; separation of earth rotation and nodal precession from initial geometric analyses; and use of symmetries to construct traces of indefinite length by repetitive transposition of basic one-quadrant elements. The complete coverage patterns generated consist of a basic nadir trace plus a number of associated off-nadir traces, one for each sensor swath edge to be delineated. Each trace is generated by transposing one or two of the basic quadrant elements into a circle on a nonrotating earth model sphere, after which the circle is expanded into the actual 'helical' pattern by adding rotational displacements to the longitude coordinates. The procedure adapts to the important periodic coverage cases by direct insertion of the characteristic integers N and R (days and orbital revolutions, respectively, per coverage period).

  8. Diet-related buccal dental microwear patterns in Central African Pygmy foragers and Bantu-speaking farmer and pastoralist populations.

    Directory of Open Access Journals (Sweden)

    Alejandro Romero

    Full Text Available Pygmy hunter-gatherers from Central Africa have shared a network of socioeconomic interactions with non-Pygmy Bantu speakers since agropastoral lifestyle spread across sub-Saharan Africa. Ethnographic studies have reported that their diets differ in consumption of both animal proteins and starch grains. Hunted meat and gathered plant foods, especially underground storage organs (USOs, are dietary staples for pygmies. However, scarce information exists about forager-farmer interaction and the agricultural products used by pygmies. Since the effects of dietary preferences on teeth in modern and past pygmies remain unknown, we explored dietary history through quantitative analysis of buccal microwear on cheek teeth in well-documented Baka pygmies. We then determined if microwear patterns differ among other Pygmy groups (Aka, Mbuti, and Babongo and between Bantu-speaking farmer and pastoralist populations from past centuries. The buccal dental microwear patterns of Pygmy hunter-gatherers and non-Pygmy Bantu pastoralists show lower scratch densities, indicative of diets more intensively based on nonabrasive foodstuffs, compared with Bantu farmers, who consume larger amounts of grit from stoneground foods. The Baka pygmies showed microwear patterns similar to those of ancient Aka and Mbuti, suggesting that the mechanical properties of their preferred diets have not significantly changed through time. In contrast, Babongo pygmies showed scratch densities and lengths similar to those of the farmers, consistent with sociocultural contacts and genetic factors. Our findings support that buccal microwear patterns predict dietary habits independent of ecological conditions and reflect the abrasive properties of preferred or fallback foods such as USOs, which may have contributed to the dietary specializations of ancient human populations.

  9. Development processes and growth pattern of Pinus densiflora stands in central eastern Korea.

    Science.gov (United States)

    Park, Pil Sun; Kim, Kyung Yoon; Han, Ahreum; Jang, Woongsoon; Son, Yowhan; Yi, Myong Jong; Park, Byung Bae; Son, Yeongmo

    2010-07-01

    Stand growth and developmental processes were investigated in Pinus densiflora Siebold et Zucc. stands of different ages in the central eastern region of Korea. Stands were inventoried and five trees per stand were sampled for stem analysis, age estimation, and growth analysis. More than 80% of sampled trees in a stand were established within 3-5 years, and most stands had a single cohort structure. The initial growth of pine seedlings was slow, but the height growth accelerated beyond 2-3 m height, 5-10 years after establishment. Linear growth was maintained until 10-12 m height, at which suppressed trees fell behind and might die out. The young stand was composed of pure pines, while few pine seedlings and saplings were found in the understory of older stands. The peak of diameter growth rate occurred around 5-15 years after tree establishment, implying that competition begins during that period. The pine stand development follows four stages: (1) the young stage when the growth rate increases and peaks; (2) the height competition stage when trees focus on height growth for light while maintaining a narrow DBH and height distribution; (3) the differentiation stage when suppressed trees die out, and the DBH distribution becomes wider; and (4) the mature stage when stands have a multi-canopy structure with a wide DBH and height distribution, while the understory is dominated by other tree species. The changes in growth rates and stand structure through forest development would be implemented to predict alterations of above-ground carbon sequestration rates.

  10. Evaluation of prescribing indicators and pattern among dermatological outpatients in a teaching hospital of central Nepal

    Directory of Open Access Journals (Sweden)

    Manohar Pradhan

    2016-08-01

    Full Text Available Background: Evaluation of prescribing indicators by proper analysis of prescriptions under the guidelines of World Health Organization enables us to detect some of the common problems of prescribing.Methodology: This study was conducted on randomly selected 325 prescriptions of dermatological outpatients of teaching hospital of College of Medical Sciences Bharatpur (Nepal with an objective to detect the problems of prescribing as well as to delineate the pattern of medicines prescribing.Results: Total number of medicines prescribed on these prescriptions was 743. The average number of medicines per encounter was 2.28. Antihistamines, antifungals, corticosteroids and antibiotics were four most frequently prescribed therapeutic classes. One systemic as well as one topical medicine belonging to same therapeutic class was prescribed on about one-third of totally analyzed prescriptions. Cetrizine was the most common individually prescribed medicine and fluconazole was the most commonly prescribed antifungal. Medicines prescribed by their generic name were 15.07% and those prescribed from national essential medicines list were 23.42%.Conclusion: This study reveals polypharmacy, inclination of prescribers for branded medicines and prescribing out of national formulary as problems. Educational and managerial interventions are required to rationalize the prescribing practice.JCMS Nepal. 2016;12(2:44-9.

  11. Initial benchmarking of a new electron-beam raster pattern generator for 130-100 nm maskmaking

    Science.gov (United States)

    Sauer, Charles A.; Abboud, Frank E.; Babin, Sergey V.; Chakarian, Varoujan; Ghanbari, Abe; Innes, Robert; Trost, David; Raymond, Frederick, III

    2000-07-01

    The decision by the Semiconductor Industry Association (SIA) to accelerate the continuing evolution to smaller linewidths is consistent with the commitment by Etec Systems, Inc. to rapidly develop new technologies for pattern generation systems with improved resolution, critical dimension (CD) uniformity, positional accuracy, and throughput. Current pattern generation designs are inadequate to meet the more advanced requirements for masks, particularly at or below the 100 nm node. Major changes to all pattern generation tools will be essential to meet future market requirements. An electron-beam (e-beam) system that is designed to meet the challenges for 130 - 100 nm device generation with extendibility to the 70-nm range will be discussed. This system has an architecture that includes a graybeam writing strategy, a new state system, and improved thermal management. Detailed changes include a pulse width modulated blanking system, per-pixel deflection, retrograde scanning multipass writing, and a column with a 50 kV accelerating voltage that supports a dose of up to 45 (mu) C/cm2 with minimal amounts of resist heating. This paper examines current issues, our approach to meeting International Technology Roadmap for Semiconductors (ITRS) requirements, and some preliminary results from a new pattern generator.

  12. A study of morbidity pattern among iron and steel workers from an industry in central India

    Directory of Open Access Journals (Sweden)

    Manish J Biswas

    2014-01-01

    Full Text Available Background: Iron is the world′s most commonly used metal and can usually be found with other elements in the form of steel. In this era of machines, it is the inevitable part in production of various materials like eyeglass frames, jet aircraft, the space shuttle, automobiles, and surgical instruments. Occupational factors make an important contribution to the global burden of disease, but the reliable data on occupational disease are much more difficult to obtain. Hence, the current study was carried out to find out the morbidity pattern among iron and steel workers Materials and Methods: A cross-sectional study. was carried out after obtaining permission from Institutional Ethics Committee in an iron and steel factory. Worker′s detailed information regarding profile was taken in pretested questionnaire format after obtaining the informed written consent and explaining the purpose of study. Workers were also interviewed regarding their years of job, job satisfaction, usage of protective devices, and history of injuries during work. Worker′s detailed general and systemic examination was conducted. Results: The overall prevalence of morbidities among the workers was 60%. It was observed that commonest morbidity in the workers was lumbago (musculoskeletal pain, that is, 33.25%which was more in Group B (49.73% than Group A (18.78%, followed by occupational dermatitis (27% which more common in Group A (33.33% than Group B (19.79%. It was seen that occupation-related morbidities were more prevalent in Group A, i.e. Exposed group (P < 0.001. Conclusion: It was observed that occupation-related morbidities were more common in exposed group (EG than that of nonexposed group (NEG and the difference was found to be statistically significant (P < 0.001.

  13. Pattern of obstetrics complication among pregnant females admitted in a tertiary care centre in central India

    Directory of Open Access Journals (Sweden)

    Manik S. Shirpurkar

    2015-04-01

    Background: About half a million women die every year of causes related to pregnancy and child birth. Complication can arise at any time during pregnancy; child birth and post natal period and in absence of intervention, there is a high feto - maternal morbidity and mortality. Aim:- To study the pattern of obstetrics complication among antenatal patients coming to a tertiary care centre. Material and Methods:- A cross sectional study was conducted among 102 antenatal women admitted in intensive care unit of our institute during July 2014 to November 2014. Data regarding maternal socio-demographic profile and antenatal profile was collected. Result:- Out of total 102 women included in the study. 95(93% were registered and 7 were unregistered women. 88(86.4% women had 3 or more antenatal visit, of which 3(2.9% were unregistered women. 82(80.3% women had blood Hb% <11; of which 7 (6.8% were unregistered women. Out of total 102 women, 64(62.7% women were having complications related to abnormal labour; 34(33.3% obstetrical disorder, 21(20.5% Hypertensive disorder. Because of multi-disciplinary team approach at our institute, no maternal mortality was reported among the antenatal women admitted during this period in our institute. Conclusion:- All women need access to antenatal care; institutional delivery and post partum care. Complication arises at any time in absence of intervention. Multidisciplinary team approach along with intensive care specialist and anaesthesiologists can bring optimum care and thereby help in reducing maternal mortality. [Int J Reprod Contracept Obstet Gynecol 2015; 4(2.000: 338-343

  14. Pattern of self-medication with analgesics among Iranian University students in central Iran

    Directory of Open Access Journals (Sweden)

    Shadi Sarahroodi

    2012-01-01

    Full Text Available Background: Self-medication is defined as the use of drugs for the treatment of self-diagnosed disorders. It is influenced by factors such as education, family, society, law, availability of drugs and exposure to advertisements. This study was performed to evaluate self-medication with analgesics and its pattern among different groups of Iranian University Students. Materials and Methods: A randomized, cross-sectional, multicenter study was conducted from December 2009 to February 2010. The target population of this study was 564 students out of 10,000 students attending four medical and non-medical science universities in Qom state. Data was analyzed using SPSS version 16, and analysis was conducted with descriptive analysis procedures. Results: 76.6% of the students had used analgesics in self-medication in the previous 3 months. The frequency of analgesic use in the study period was once in 19.2% of the participants, twice in 22.2%, three times in 16.3% and more than three times in 35.5% of the participants, although 6.8% of them were not sure when they were used. Of all the respondents, 49.8% reported headache as the problem. This was the most common problem, after which came Dysmenorrhea,headache and stomach ache. Bone and joint pains were other problems that led to the use of analgesics. The most commonly used source of information for self-medication with analgesics was advice from friends and family (54.7%, previously prescribed medications (30.1%, their medical knowledge (13.3% and recommendation of a pharmacist (1.9%. Conclusion: Self-medication with analgesics is very high among Iranian students in Qom city. This could be an index for other parts of the Iranian community. Because the source of information about analgesics is inappropriate, we would recommend education courses about analgesics and self-medication on the radio and television for the entire population.

  15. The tree water isoscape of a central Pennsylvania catchment: ecohydrologic patterns and processes

    Science.gov (United States)

    Brubaker, K. M.; Gaines, K.

    2015-12-01

    The connections between vegetation and catchment hydrology are important for tree physiology, plant geography, stream flow, and transport of solutes within a watershed. While water isotopes from tree stems have been studied extensively to examine source-water differences at a small scale, there has been little emphasis on modeling of plant stem water isotopes at larger scales, due to the expensive and laborious extraction and analysis processes. We characterized the tree stem water for stable isotopes over a landscape (isoscape) at a first-order catchment in central Pennsylvania in order to address the following questions: 1) How does tree water isotopic composition relate to catchment topography and tree characteristics? 2) What are the underlying hydrologic processes that are revealed by tree water isotopes? We used 267 observations of tree xylem water δ18O from 121 trees to build a statistical model with candidate variables related to topography and tree characteristics. We then applied the final model to predict the tree xylem water δ18O composition during the growing season of the remaining trees defined as > 18-cm diameter (at breast height; DBH) in the catchment. The final model included tree canopy height and slope magnitude as predictors, and explained about 56% of variance in tree water δ18O composition in the catchment. Tree canopy height and degree of slope were both negatively related to tree water δ18O suggesting the tallest trees and trees on the steepest slopes had tree water isotopic compositions most depleted in heavy isotopes. Each of these suggested the influence of cool-season isotopic inputs. On the valley floor, where tree canopy heights were tallest, the tree water δ18O composition was likely due to early growing season soil saturation from a shallow ground water table. Conversely, the steep hill slope δ18O composition may be a result of tree water use of tightly-bound soil water originating from cool season precipitation. The model

  16. Dopaminergic Receptors and Tyrosine Hydroxylase Expression in Peripheral Blood Mononuclear Cells: A Distinct Pattern in Central Obesity

    Science.gov (United States)

    Leite, Fernanda; Lima, Margarida; Marino, Franca; Cosentino, Marco; Ribeiro, Laura

    2016-01-01

    Background Dopamine (DA) may be involved in central obesity (CO), an inflammatory condition, through its role in the central nervous system and in periphery, where it may affect immune cell function through five different DA receptors (DR). Whether dopaminergic pathways in peripheral immune cells are implicated in the inflammatory condition linked to CO is however unknown. Methods In a cohort of blood donors with and without CO, categorized by waist circumference (WC) (CO: WC ≥0.80 m in women and ≥0.94 m in men), we studied the expression of DR and tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of DA, in peripheral blood mononuclear cells (PBMCs) and their relation with anthropometric and metabolic/endocrine and inflammatory parameters. DR D1-5 and TH expression was assessed by semi quantitative real-time PCR. As inflammatory markers we investigated the immunophenotype of monocyte subsets by flow cytometry, staining for CD14, CD16, CD11b and CD36. Results CO individuals showed higher plasma levels of leptin and higher inflammatory pattern of monocytes compared with non-CO. PBMC expression of DR D2, DR D4 and DR D5 as well as of TH were lower in CO in comparison with non-CO. DR D2, and DR D5 expression correlated with lower WC and weight, and with lower inflammatory pattern of monocytes, and TH expression correlated with lower WC. DR D4 expression correlated with lower plasma levels of glycosylated hemoglobin, and DR D2 expression correlated with lower CO. Conclusions Results show that CO is associated with peripheral inflammation and downregulation of dopaminergic pathways in PBMCs, possibly suggesting DR expressed on immune cells as pharmacological targets in obesity for better metabolic outcome. PMID:26808524

  17. Spatiotemporal Patterns of the Use of Urban Green Spaces and External Factors Contributing to Their Use in Central Beijing

    Science.gov (United States)

    Li, Fangzheng; Zhang, Fen; Li, Xiong; Wang, Peng; Liang, Junhui; Mei, Yuting; Cheng, Wenwen; Qian, Yun

    2017-01-01

    Urban green spaces encourage outdoor activity and social communication that contribute to the health of local residents. Examining the relationship between the use of urban green spaces and factors influencing their utilization can provide essential references for green space site selection in urban planning. In contrast to previous studies that focused on internal factors, this study highlights the external factors (traffic convenience, population density and commercial facilities) contributing to the use of urban green spaces. We conducted a spatiotemporal analysis of the distribution of visitors in 208 selected green spaces in central Beijing. We examined the relationship between the spatial pattern of visitor distribution within urban green spaces and external factors, using the Gini coefficient, kernel density estimation, and geographical detectors. The results of the study were as follows. The spatial distribution of visitors within central Beijing’s green spaces was concentrated, forming different agglomerations. The three examined external factors are all associated with the use of green spaces. Among them, commercial facilities are the important external factor associated with the use of green spaces. For the selection of sites for urban green spaces, we recommend consideration of external factors in order to balance urban green space utilization. PMID:28264451

  18. Spatiotemporal Patterns of the Use of Urban Green Spaces and External Factors Contributing to Their Use in Central Beijing

    Directory of Open Access Journals (Sweden)

    Fangzheng Li

    2017-02-01

    Full Text Available Urban green spaces encourage outdoor activity and social communication that contribute to the health of local residents. Examining the relationship between the use of urban green spaces and factors influencing their utilization can provide essential references for green space site selection in urban planning. In contrast to previous studies that focused on internal factors, this study highlights the external factors (traffic convenience, population density and commercial facilities contributing to the use of urban green spaces. We conducted a spatiotemporal analysis of the distribution of visitors in 208 selected green spaces in central Beijing. We examined the relationship between the spatial pattern of visitor distribution within urban green spaces and external factors, using the Gini coefficient, kernel density estimation, and geographical detectors. The results of the study were as follows. The spatial distribution of visitors within central Beijing’s green spaces was concentrated, forming different agglomerations. The three examined external factors are all associated with the use of green spaces. Among them, commercial facilities are the important external factor associated with the use of green spaces. For the selection of sites for urban green spaces, we recommend consideration of external factors in order to balance urban green space utilization.

  19. Lack of differential pattern in central adiposity and metabolic syndrome in Barrett's esophagus and gastroesophageal reflux disease.

    LENUS (Irish Health Repository)

    Healy, L A

    2012-02-01

    Obesity is an established risk factor for esophageal adenocarcinoma, although the mechanism is unclear. A pathway from reflux to inflammation through metaplasia is the dominant hypothesis, and an added role relating to visceral adiposity and the metabolic syndrome has been mooted in Barrett\\'s esophagus (BE) patients. Whether BE differs from gastroesophageal reflux disease (GERD) in obesity and metabolic syndrome profiles is unclear, and this was the focus of this study. Patients with proven BE or GERD were randomly selected from the unit data registry and invited to attend for metabolic syndrome screening, anthropometry studies including segmental body composition analysis, and laboratory tests including fasting lipids, insulin, and C-reactive protein. Metabolic syndrome was defined using the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria. One hundred and eighteen BE patients and 113 age- and sex-matched GERD controls were studied. The incidence of obesity (body mass index >30 kg\\/m(2)) was 36% and 38%, respectively, with the pattern of fat deposition predominantly central and an estimated trunk fat mass of 13 and 14 kg, respectively. Using the NCEP criteria, metabolic syndrome was significantly more common in the BE cohort (30% vs 20%, P < 0.05), but there was no significant difference using IDF criteria (42% vs 37%, P= 0.340). Central obesity and the metabolic syndrome are common in both Barrett\\'s and GERD cohorts, but not significantly different, suggesting that central obesity and the metabolic syndrome does not per se impact on the development of BE in a reflux population. In BE, the importance of obesity and the metabolic syndrome in disease progression merits further study.

  20. Brainstem involvement as a cause of central sleep apnea: pattern of microstructural cerebral damage in patients with cerebral microangiopathy.

    Directory of Open Access Journals (Sweden)

    Thomas Duning

    Full Text Available BACKGROUND: The exact underlying pathomechanism of central sleep apnea with Cheyne-Stokes respiration (CSA-CSR is still unclear. Recent studies have demonstrated an association between cerebral white matter changes and CSA. A dysfunction of central respiratory control centers in the brainstem was suggested by some authors. Novel MR-imaging analysis tools now allow far more subtle assessment of microstructural cerebral changes. The aim of this study was to investigate whether and what severity of subtle structural cerebral changes could lead to CSA-CSR, and whether there is a specific pattern of neurodegenerative changes that cause CSR. Therefore, we examined patients with Fabry disease (FD, an inherited, lysosomal storage disease. White matter lesions are early and frequent findings in FD. Thus, FD can serve as a "model disease" of cerebral microangiopathy to study in more detail the impact of cerebral lesions on central sleep apnea. PATIENTS AND METHODS: Genetically proven FD patients (n = 23 and age-matched healthy controls (n = 44 underwent a cardio-respiratory polysomnography and brain MRI at 3.0 Tesla. We applied different MR-imaging techniques, ranging from semiquantitative measurement of white matter lesion (WML volumes and automated calculation of brain tissue volumes to VBM of gray matter and voxel-based diffusion tensor imaging (DTI analysis. RESULTS: In 5 of 23 Fabry patients (22% CSA-CSR was detected. Voxel-based DTI analysis revealed widespread structural changes in FD patients when compared to the healthy controls. When calculated as a separate group, DTI changes of CSA-CSR patients were most prominent in the brainstem. Voxel-based regression analysis revealed a significant association between CSR severity and microstructural DTI changes within the brainstem. CONCLUSION: Subtle microstructural changes in the brainstem might be a neuroanatomical correlate of CSA-CSR in patients at risk of WML. DTI is more sensitive and specific than

  1. Two interconnected kernels of reciprocally inhibitory interneurons underlie alternating left-right swim motor pattern generation in the mollusk Melibe leonina.

    Science.gov (United States)

    Sakurai, Akira; Gunaratne, Charuni A; Katz, Paul S

    2014-09-15

    The central pattern generator (CPG) underlying the rhythmic swimming behavior of the nudibranch Melibe leonina (Mollusca, Gastropoda, Heterobranchia) has been described as a simple half-center oscillator consisting of two reciprocally inhibitory pairs of interneurons called swim interneuron 1 (Si1) and swim interneuron 2 (Si2). In this study, we identified two additional pairs of interneurons that are part of the swim CPG: swim interneuron 3 (Si3) and swim interneuron 4 (Si4). The somata of Si3 and Si4 were both located in the pedal ganglion, near that of Si2, and both had axons that projected through the pedal commissure to the contralateral pedal ganglion. These neurons fulfilled the criteria for inclusion as members of the swim CPG: 1) they fired at a fixed phase in relation to Si1 and Si2, 2) brief changes in their activity reset the motor pattern, 3) prolonged changes in their activity altered the periodicity of the motor pattern, 4) they had monosynaptic connections with each other and with Si1 and Si2, and 5) their synaptic actions helped explain the phasing of the motor pattern. The results of this study show that the motor pattern has more complex internal dynamics than a simple left/right alternation of firing; the CPG circuit appears to be composed of two kernels of reciprocally inhibitory neurons, one consisting of Si1, Si2, and the contralateral Si4 and the other consisting of Si3. These two kernels interact with each other to produce a stable rhythmic motor pattern.

  2. Design and thermal analysis of a direct steam generation central-receiver solar thermal power plant

    OpenAIRE

    Garrido Camino, Carlos

    2013-01-01

    Thermo-solar central receiver power plants use radiation coming from the Sun, a clean energy source, to produce electricity. The best locations for this type of installations are the ones between 30º and 40º of latitude, both in the northern and southern hemisphere, what makes Spain to be one of the most suitable and attractive places all over the world for this energy source. However, this technology is not well developed yet comparing to other renewable energy sources such as wind energy or...

  3. Centralized Control Architecture for Coordination of Distributed Renewable Generation and Energy Storage in Islanded AC Microgrids

    DEFF Research Database (Denmark)

    Aldana, Nelson Leonardo Diaz; Hernández, Adriana Carolina Luna; Quintero, Juan Carlos Vasquez;

    2017-01-01

    The coordinated operation of distributed energy resources such as storage and generation units and also loads is required for the reliable operation of an islanded microgrid. Since in islanded microgrids the storage units are commonly responsible for regulating the voltage amplitude and frequency...

  4. CENCAL_BASELINE - Offshore Baseline for Central California Generated to Calculate Shoreline Change Rates

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Rates of long-term and short-term shoreline change were generated in a GIS using the Digital Shoreline Analysis System (DSAS) version 3.0; An ArcGIS extension for...

  5. Evaluation of electricity generation and energy cost of wind energy conversion systems (WECSs) in Central Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Goekcek, Murat [Department of Mechanical Engineering, Faculty of Engineering and Architecture, Nigde University Campus, 51100 Nigde (Turkey); Genc, Mustafa Serdar [Department of Airframe and Powerplant, School of Civil Aviation, Erciyes University, 38039 Kayseri (Turkey)

    2009-12-15

    The negative effects of non-renewable fossil fuels have forced scientists to draw attention to clean energy sources which are both environmentally more suitable and renewable. Although Turkey enjoys fairly high wind energy potential, an investigation and exploitation of this source is still below the desired level. In this study which is a preliminary study on wind energy cost in Central Anatolian-Turkey, the wind energy production using time-series approach and the economic evaluation of various wind energy conversion systems (WECSs) enjoying the 2.5, 5, 10, 20, 30, 50, 100 and 150 kW rated power size using the levelised cost of electricity (LCOE) method for the seven different locations in Central Turkey were estimated. In addition, effects of escalation ratio of operation and maintenance cost and annual mean speed on LCOE are taken into account. The wind speed data for a period between 2000 and 2006 years were taken from Turkish State Meteorological Service (TSMS). According to the result of the calculations, it is shown that the WECS of capacity 150 kW produce the energy output 120,978 kWh per year in the Case-A (Pinarbasi) for hub height 30 m and also the LCOE varies in the range of 0.29-30.0$/kWh for all WECS considered. (author)

  6. Effect of HF Heating Array Directivity Pattern on the Frequency Response of Generated ELF/VLF.

    Science.gov (United States)

    1983-01-01

    hhEEE|hhEE 1H ; 11:j28 111125 . mm 11111 II ll1 111 .8 MICROCOPY RESOLUTION TESI CHART I fJC ’RL_-SCI-475l I( .-cmon Numters: 1.5.1. 3.1.4, 3.2.1,.3.3...the high power HF heating facility at the Arecibo Observatory in Puerto Rico. The pattern was calculated using pattern multi- plication and method of...high power HF heating facility at the Arecibo Observatory in Puerto Rico. The pattern was calculated using pattern multiplication and method of

  7. Seasonal and diel patterns of total gaseous mercury concentration in the atmosphere of the Central Valley of Costa Rica

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, Aylin; Valdes, Juan; Sibaja, Jose; Vega, Ilena; Alfaro, Rosa; Morales, Jose; Esquivel, Germain; Barrantes, Elisa [Laboratory for Atmospheric Chemistry, LAQAT-UNA, Universidad Nacional, P.O. Box 86-3000, Heredia (Costa Rica); Black, Paleah [Department of Biology, University of Ottawa, P.O. Box 450 Station A, Ottawa, Ontario, K1N 6N5 (Canada); Lean, David, E-mail: drslean@gmail.com [P.O. Box 309, Apsley, Ontario, K0L 1A0 (Canada)

    2011-02-15

    Research highlights: {yields} Elevated seasonal and daily patterns of total gaseous mercury (TGM) were observed in the Central Valley of Costa Rica 27 km south-east of the Poas volcano. {yields} With the onset of the wet season TGM in late April, values increased from typical values near 10 to 905 ng m{sup -3}. {yields} During the day, TGM values increased until midday along with temperature and radiation but relative humidity showed a reciprocal pattern. {yields} We conclude that elemental mercury from the volcano may react with atmospheric oxidants especially during the dry season and the mercury would be deposited to the ground. {yields} With the onset of heavy rains, mercury in the soil is reduced and re-volatilized resulting in the high levels in atmospheric air at the end of April. - Abstract: Monitoring of Hg in the atmosphere near volcanoes is limited with no previous data for Costa Rica. Seasonal and daily patterns of total gaseous mercury (TGM) were observed at the main sampling location at the Universidad Nacional, Heredia, Costa Rica. The area (lat. 10.000230 long. -84.109499) is located in the Central Valley of Costa Rica and is 27 km SE of the Poas volcano (lat. 10.199486 long. -84.231388). Measurements were made from May 2008 to May 2009 at this location with some additional values obtained at other sites near the Poas volcano including San Luis and Grecia as well as near, Turrialba and Irazu volcanoes. Total gaseous Hg was determined in samples collected at a height of 2 m using the Tekran 2537A (Tekran Inc.) gas-phase Hg vapor analyzer. Meteorological data (temperature, relative humidity, wind speed, wind direction, radiation and precipitation) were obtained from the airport weather station located at Alajuela. Monthly precipitation is typically 85 mm during the dry season (December to April) with winds from the west. The wet season begins in late April and continues to December with monthly rainfall of 328 mm and winds from the NE. The annual mean

  8. Performance analysis of a Kalina cycle for a central receiver solar thermal power plant with direct steam generation

    DEFF Research Database (Denmark)

    Modi, Anish; Haglind, Fredrik

    2014-01-01

    Solar thermal power plants have attracted increasing interest in the past few years - with respect to both the design of the various plant components, and extending the operation hours by employing different types of storage systems. One approach to improve the overall plant efficiency is to use...... without corroding the equipment by using suitable additives with the mixture. The purpose of the study reported here was to investigate if there is any benefit of using a Kalina cycle for a direct steam generation, central receiver solar thermal power plant with high live steam temperature (450 C...... direct steam generation with water/steam as both the heat transfer fluid in the solar receivers and the cycle working fluid. This enables operating the plant with higher turbine inlet temperatures. Available literature suggests that it is feasible to use ammonia-water mixtures at high temperatures...

  9. Centralized optical-frequency-comb-based RF carrier generator for DWDM fiber-wireless access systems

    DEFF Research Database (Denmark)

    Pang, Xiaodan; Beltran, Marta; Sanchez, Jose;

    2014-01-01

    In this paper, we report on a gigabit capacity fiber-wireless system that enables smooth integration between high-speed wireless networks and dense wavelength-division-multiplexing (DWDM) access networks. By employing a centralized optical frequency comb, both the wireline and the wireless services....... For demonstration, we transmit a 2.5 Gbit/s signal through the proposed system and successfully achieve a bit-error-rate (BER) performance well below the 7% overhead forward error correction limit of the BER of 2 × 10¿3 for both the wireline and the wireless signals in the 60 GHz band after 25 km single-mode fiber...... for each DWDM user can be simultaneously supported. Besides, each baseband channel can be transparently upconverted tomultiple radio-frequency (RF) bands for different wireless standards, which can be flexibly filtered at the end user to select the on-demand RF band, depending on the wireless applications...

  10. Control and Modulation Techniques for a Centralized PV Generation System Grid Connected via an Interleaved Inverter

    Directory of Open Access Journals (Sweden)

    Gianluca Brando

    2016-09-01

    Full Text Available In the context of grid connected photovoitaic (PV generation systems, there are two paramount aspects regarding the Maximum Power Point Tracking (MPPT of the photovoltaic units and the continuity of the service. The most diffused MPPT algorithms are based on either perturb and observe, or on an incremental conductance approach and need both PV current and voltage measurements. Several topology reconfigurable converters are also associated with the PV plants, guaranteeing fault-tolerant features. The generation continuity can also be assured by interleaved inverters, which keep the system operating at reduced maximum power in case of failure. In this paper, an evolution of a hysteresis based MPPT algorithm is presented, based on the measurement of only one voltage, together with a novel space vector modulation suitable for a two-channel three-phase grid connected interleaved inverter. The proposed MMPT algorithm and modulation technique are tested by means of several numerical analyses on a PV generation system of about 200 kW maximum power. The results testify the validity of the proposed strategies, showing good performance, even during a fault occurrence and in the presence of deep shading conditions.

  11. Implementing a Generative Urban Design Model: Grammar-based design patterns for urban design

    NARCIS (Netherlands)

    Beirao, J.N.; Mendes, G.; Duarte, J.; Stouffs, R.M.F.

    2010-01-01

    This paper shows the first results of a prototype implementation of a generative urban design tool. This implementation will form part of a design support tool for a GIS based platform defined to formulate, generate and evaluate urban designs. These three goals, formulation, generation and evaluatio

  12. Contrasting patterns of climatic changes during the Holocene in the Central Mediterranean (Italy reconstructed from pollen data

    Directory of Open Access Journals (Sweden)

    O. Peyron

    2012-11-01

    Full Text Available Lake-level records from Italy suggest a north–south climatic partition in the Central Mediterranean during the Holocene with respect to precipitation, but the scarcity of reliable palaeoclimatic records in the North and Central-Southern Mediterranean means new evidence is needed to validate this hypothesis. Here, we provide robust quantitative estimates of Holocene climate in the Mediterranean region based on four high-resolution pollen records from Northern (Lakes Ledro and Accesa and Southern (Lakes Trifoglietti and Pergusa Italy. Multiple methods are used to provide an improved assessment of the paleoclimatic reconstruction uncertainty. The multi-method approach uses the pollen-based Weighted Averaging, Weighted-Average-Partial-Least-Squares regression, Modern Analogues Technique, and the Non-Metric-Multidimensional Scaling/Generalized-Additive-Model methods. The precipitation seasonality reconstructions are validated by independent lake-level data, obtained from the same records.

    A climatic partition between the north and the south during the Holocene confirms the hypothesis of opposing mid-Holocene summer precipitation regimes in the Mediterranean. During the early-to-mid-Holocene the northern sites (Ledro, Accesa are characterized by minima for summer precipitation and lake-levels while the southern sites (Trifoglietti, Pergusa are marked by maxima for precipitation and lake-levels. During the late Holocene, both pollen-inferred precipitation and lake-levels indicate the opposite pattern, a maximum in North Italy and a minimum in Southern Italy/Sicily. Summer temperatures also show partitioning, with warm conditions in Northern Italy and cool conditions in Sicily during the early/mid-Holocene, and a reversal during the Late-Holocene.

    Comparison with marine cores from the Aegean Sea suggests that climate trends and gradients observed in Italy shows strong similarities with those recognized from the Aegean Sea, and more

  13. [Isoforms of the human histamine H3 receptor: Generation, expression in the central nervous system and functional implications].

    Science.gov (United States)

    García-Gálvez, Ana Maricela; Arias-Montaño, José Antonio

    2016-01-01

    Histamine plays a significant role as a neuromodulator in the human central nervous system. Histamine-releasing neurons are exclusively located in the tuberomammillary nucleus of the hypothalamus, project to all major areas of the brain, and participate in functions such as the regulation of sleep/wakefulness, locomotor activity, feeding and drinking, analgesia, learning, and memory. The functional effects of histamine are exerted through the activation of four G protein-coupled receptors (H1, H2, H3 and H4), and in the central nervous system the first three receptors are widely expressed. The H3 receptor (H3R) is found exclusively in neuronal cells, where it functions as auto- and hetero-receptor. One remarkable characteristic of the H3R is the existence of isoforms, generated by alternative splicing of the messenger RNA. For the human H3R, 20 isoforms have been reported; although a significant number lack those regions required for agonist binding or receptor signaling, at least five isoforms appear functional upon heterologous expression. In this work we review the evidence for the generation of human H3R isoforms, their expression, and the available information regarding the functionality of such receptors.

  14. Contrasting demographic history and gene flow patterns of two mangrove species on either side of the Central American Isthmus.

    Science.gov (United States)

    Cerón-Souza, Ivania; Gonzalez, Elena G; Schwarzbach, Andrea E; Salas-Leiva, Dayana E; Rivera-Ocasio, Elsie; Toro-Perea, Nelson; Bermingham, Eldredge; McMillan, W Owen

    2015-08-01

    Comparative phylogeography offers a unique opportunity to understand the interplay between past environmental events and life-history traits on diversification of unrelated but co-distributed species. Here, we examined the effects of the quaternary climate fluctuations and palaeomarine currents and present-day marine currents on the extant patterns of genetic diversity in the two most conspicuous mangrove species of the Neotropics. The black (Avicennia germinans, Avicenniaceae) and the red (Rhizophora mangle, Rhizophoraceae) mangroves have similar geographic ranges but are very distantly related and show striking differences on their life-history traits. We sampled 18 Atlantic and 26 Pacific locations for A. germinans (N = 292) and R. mangle (N = 422). We performed coalescence simulations using microsatellite diversity to test for evidence of population change associated with quaternary climate fluctuations. In addition, we examined whether patterns of genetic variation were consistent with the directions of major marine (historical and present day) currents in the region. Our demographic analysis was grounded within a phylogeographic framework provided by the sequence analysis of two chloroplasts and one flanking microsatellite region in a subsample of individuals. The two mangrove species shared similar biogeographic histories including: (1) strong genetic breaks between Atlantic and Pacific ocean basins associated with the final closure of the Central American Isthmus (CAI), (2) evidence for simultaneous population declines between the mid-Pleistocene and early Holocene, (3) asymmetric historical migration with higher gene flow from the Atlantic to the Pacific oceans following the direction of the palaeomarine current, and (4) contemporary gene flow between West Africa and South America following the major Atlantic Ocean currents. Despite the remarkable differences in life-history traits of mangrove species, which should have had a strong influence on seed

  15. Determination of activity by gamma spectrometry of radionuclides present in drums of residues generated in nuclear centrals; Determinacion de actividad por espectrometria gamma de radionucleidos presentes en tambores de residuos generados en centrales nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, J.C.; Fernandez, J. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250, Ciudad Autonoma de Buenos Aires (Argentina)]. e-mail: jaguiar@cae.arn.gov.ar

    2006-07-01

    The generation of radioactive residuals in nuclear centrals as CNA I (Atucha I Nuclear Central) and CNE (Embalse Nuclear Central) makes that the measurement of those radionuclides has been a previous stage to the waste management. A method used in those nuclear centrals it is the gamma spectrometry with HPGe detectors, previous to the immobilization of the residual in a cemented matrix, with this the contact with the external agents and its possible dispersion to the atmosphere in the short term is avoided. The ARN (Nuclear Regulatory Authority) of Argentina it carries out periodically intercomparisons and evaluations of the measurement and procedures systems used in the nuclear power stations for the correct measurement and determination of activity of radioactive residuals by gamma spectrometry. In this work an independent method of measurement is exposed to the nuclear power stations. To determine the activity of the residuals by gamma spectrometry deposited in drums, it is required of the precise knowledge of the efficiency curve for such geometry and matrix. Due to the RNA doesn't have a pattern of these characteristics, a mathematical model has been used to obtain this efficiency curve. For it, it is necessary to determine previously: 1) the geometric efficiency or solid angle sustained by the source-detector system (drum-detector) applying a mathematical model described in this work. 2) To estimate the auto-attenuation factor that present the photons in the cemented matrix, these calculations are carried out with a simple equation and its are verified with the Micro Shield 6.10 program. The container commonly used by these nuclear power stations its are drums for 220 liters constructed with SAE 1010 steel and with a thickness of 0.127 cm, with an approximate weight 7.73 Kg., internal diameter of 57.1 cm, and height: 87 cm. The results obtained until the moment register a discrepancy from 5 to 10% with relationship to the measurements carried out by the

  16. The importance of peers: assimilation patterns among second-generation Turkish immigrants in Western Europe

    NARCIS (Netherlands)

    Ali, S.; Fokkema, C.M.

    2011-01-01

    The two dominant approaches to immigrant assimilation, segmented assimilation and "new" assimilation theories, have been successful at reporting and analyzing between-group differences in assimilation patterns. However, studies of assimilation generally do not address differences at the individual l

  17. Characteristics of overland flow generation on steep forested hillslopes of central Japan

    Science.gov (United States)

    Gomi, Takashi; Sidle, Roy C.; Ueno, Masayasu; Miyata, Shusuke; Kosugi, Ken'ichirou

    2008-11-01

    SummaryOverland flow generation was monitored in large plots (8 × 25 m) on four hillslopes in a 4.9-ha catchment in Mie Prefecture, Japan. Three Japanese cypress (hinoki, Chamaecyparis obtusa) treatments (including three different understory conditions) and one deciduous forest treatment were studied. For all plots, including deciduous hillslopes, we observed overland flow even for small storm events (180 mm, runoff from Japanese cypress plots with dense fern understory exhibited a delayed and higher peak associated with return flow. The dominance of hillslope-scale flow contribution to catchment runoff was also affected by changes in the dominance of overland flow and return flow. Understory vegetation cover and the availability of a litter layer altered the amount of overland flow, which was mediated by soil water repellency and soil moisture. Observations at the hillslope scale are essential for conceptualization of runoff mechanisms and pathways in forested headwaters.

  18. Convective thermal fluxes in unsteady non-homogeneous flows generating complex three dimensional vorticity patterns

    Science.gov (United States)

    Tellez Alvarez, Jackson David; Redondo, Jose Manuel; Sanchez, Jesu Mary

    2016-04-01

    The improvements in experimental methods and high resolution image analysis are nowadays able to detect subtle changes in the structure of the turbulence over a wide range of temporal and spatial scales [1], we compare the scaling shown by different mixing fronts driven by buoyancy that form convective driven mixing. We use PIV and density front tracking in several experimental configurations akin to geophysical overturning [2, 3]. We parametrize the role of unstable stratification by means of the Rayleigh and Atwood numbers and compare the scaling and the multifractal structure functions of the different markers used to visualize the non-homogeneous. Both reactive and passive scalar tracers are used to investigate the mixing structure and the intermittency of the flow. Different initial conditions are compared and the mixing efficiency of the overall turbulent process is evaluated [4 - 6]. Diffusion is measured in the transition from a homogeneous linearly stratified fluid to a cellular or layered structure by means of Thermoelectric generated heating and cooling [2, 4]. Patterns arise by setting up a convective flow generated by a buoyant heat flux either in the base or in a side wall of the convective enclosure [1, 6]. The experiments described here investigate high Prandtl number mixing using brine or sugar solutions and fresh water in order to form a density interface and low Prandtl number mixing with only temperature gradients [7]. The set of dimensionless parameters define conditions of numeric and small scale laboratory modeling of environmental flows. Fields of velocity, density and their gradients were computed and visualized [8, 9]. When convective heating and cooling takes place the combination of internal waves and buoyant turbulence is much more complicated if the Rayleigh and Reynolds numbers are high in order to study entrainment and mixing. The experiments described here investigate high Prandtl number mixing using salt or sugar solutions and

  19. Rough set based decision rule generation to find behavioural patterns of customers

    Indian Academy of Sciences (India)

    L SUMALATHA; P UMA SANKAR; B SUJATHA

    2016-09-01

    Rough sets help in finding significant attributes of large data sets and generating decision rules for classifying new instances. Though multiple regression analysis, discriminant analysis, log-it analysis and several other techniques can be used for predicting results, they consider insignificant information also for processing which may lead to false positives and false negatives. In this study, we proposed rough set based decision rule generation framework to find reduct and to generate decision rules for predicting the Decision class. We conducted experiments over data of Portuguese Banking institution. From the proposed method, the dimensionality of data is reduced and decision rules are generated which predicts deposit nature of customers by 90%accuracy.

  20. Generation of arbitrary lithographic patterns using Bose-Einstein-condensate interferometry

    Science.gov (United States)

    Fouda, M. F.; Fang, R.; Ketterson, J. B.; Shahriar, M. S.

    2016-12-01

    We propose an arbitrary pattern lithography process using interference of Bose-Einstein condensates (BECs). A symmetric three-pulse Raman atom interferometer (AI) is used to implement the system. The pattern information, in the form of a phase-only mask, is optically encoded into the BEC order parameter in one of the AI arms. The lithographic pattern is represented by a two-dimensional intensity variation, and is transformed into a two-dimensional phase variation in the BEC order parameter via the use of ac-Stark shift induced by a pulsed laser field. The BEC probability distribution of the interference result at the end of the AI is proportional to the required pattern. In order to produce features smaller than the diffraction limit for the used optical elements, we employ a three-dimensional atomic lens system to scale down the resulting pattern. The operating conditions for this lens structure are investigated in order to identify practical constraints. Simulations of the overall system using the parameters of 87Rb BEC were performed to illustrate its functionality. The proposed process, while perhaps not suitable for general purpose usage, may enable the creation of special purpose patterns on a very small scale, with features as small as a few nanometers.

  1. Patterns of mouse reticulon 3 mRNA and protein expression in the mouse central nervous system

    Institute of Scientific and Technical Information of China (English)

    LIU Jin; QIANG Boqin; YUAN Jiangang; HUANG Xiaowei; PENG Xiaozhong; YANG Hongbo; YIN Bin; TAN Xinyu; FAN Ming; FAN Wenhong; LIU Bingyan

    2003-01-01

    Reticulons (RTN) are endoplasmic reticulumassociated protein complexes, which are localized in the endoplasmic reticulum (ER) and identified as markers for neuroendocrine differentiation. At least four different RTN genes have been identified in mammals, but in most cases,the functions of the encoded proteins except mammalian RTN4-A and RTN4-B are still elusive. In the present study,mouse reticulon 3 (mRTN3) is cloned and its expression pattern in a variety of tissues is investigated. Three alternatively spliced transcripts of 1.8, 2.8 and 4.2 kb are revealed by Northern blotting hybridization. The 1.8 and 2.8 kb transcripts are expressed in many tissues. The 2.8 kb transcript has a high level in brain and the 4.2 kb transcript is only found in brain. In situ hybridization and immunohistochemical analysis indicated its high expression in non-glial cells in some particular region of mouse central nervous system, such as hippocampus, sub-thalamus nucleus, thalamus nucleus and cerebrum cortex.

  2. Late Holocene spatial patterns of coseismic land level changes and earthquake rupture areas, south-central Alaska

    Science.gov (United States)

    Shennan, I.; Barlow, N.; Watcham, E.

    2010-12-01

    Previous investigations of multiple late Holocene earthquake events in Cook Inlet suggest different spatial patterns of co-seismic subsidence for the 1964, ~900 BP and ~1500 BP great earthquakes . One hypothesis to explain these differences is that they record variations in the location, extent or depth of the rupture zone. Testing this hypothesis is important if we are to reduce uncertainties regarding the nature of future earthquake hazard in south central Alaska and improve our understanding of the nature of past earthquake ruptures in this region. Here we study sites beyond Cook Inlet to address the issue of spatial variability; Copper River Delta and Cape Suckling record coseismic uplift, Middle Bay and Anton Larson Bay, Kodiak Island, record coseismic subsidence. The 1964 rupture involved two segments (Kodiak and Prince William Sound) of the Aleutian Megathrust. We aim to quantify coseismic deformation for three Late Holocene earthquakes: ~500BP, a single segment rupture of the Kodiak segment; and ~900 and ~1500BP earthquakes that we consider involved simultaneous rupturing of three segments. These are the Kodiak and Prince William Sound segments and the adjacent segment extending to the Pamplona - Malaspina thrust front in the east. In this scenario, the Yakataga seismic gap ruptures in conjunction with the Aleutian megathrust.

  3. Estuarine use and movement patterns of seven sympatric Mugilidae fishes: The Tatu Creek estuary, central western Taiwan

    Science.gov (United States)

    Chang, Chih-Wei; Iizuka, Yoshiyuki

    2012-06-01

    By combining the spatio-temporal distribution of fish abundance and their size structure, and a detailed lifetime Sr/Ca ratio analysis in their otoliths, this study delineates the estuarine use and the movement patterns of seven sympatrical occurring adult mullets in the Tatu Creek estuary, central western Taiwan. In the estuary Mugil cephalus are the most dominant species, whereas Liza subviridis, Liza macrolepis and Liza haematocheilus are common, and Liza affinis, Liza dussumieri and Valamugil seheli are rare. They have adapted a size-related salinity preference. A mean Sr/Ca ratio of (7.5-10.2) × 10-3 in the otolith cores demonstrated that all seven mullet species spawned in the sea. After recruiting to the estuary (mean ratios of (3.6-6.4) × 10-3 at the estuarine check in the otoliths), the ratios fluctuate between (0.1-3.5) × 10-3 and (9.5-19.5) × 10-3 indicating that the mullet shared a common movement between marine and brackish waters and probably even freshwater habitats. However, the profiles fluctuated substantially among individuals. There was high intra-specific variation among M. cephalus and L. subviridis, intermediate intra-specific variation among L. macrolepis and L. affinis, and relatively little among L. haematocheilus, L. dussumieri and V. seheli. Persistent residency in high or low saline environments was found to vary among species, and the extent of their catadromy is discussed.

  4. Temporal patterns of domestic and wildlife rabies in central Namibia stock-ranching area, 1986-1996.

    Science.gov (United States)

    Courtin, F; Carpenter, T E; Paskin, R D; Chomel, B B

    2000-01-05

    Eleven years (1986-1996) of wildlife- and domestic-rabies data from the agriculture stock-ranching area of central Namibia were studied using time-series analysis. Nine hundred and sixty three rabies cases were observed in domestic ruminants (5.4 cases/mo), black-backed jackals (Canis mesomelas, 1.3 cases/mo), domestic dogs (0.5 case/mo), and bat-eared foxes (Otocyon megalotis, 0.1 case/mo). The incidence of rabies for all species did not change significantly over the whole study period. However, seasonal variations with an increase in the number of cases between June and November of each year, as well as 34 yr cyclical fluctuations were identified in domestic ruminants and black-backed jackals. The black-backed jackal time-series variable was a significant predictor of the domestic-ruminant and dog time-series variables. The rainfall seasonality combined with the seasonal reproductive pattern of the black-backed jackal appeared to be plausible explanations for the seasonal variations of rabies. However, there was no overall significant correlation between the cyclical weather fluctuations and the 3-4 yr cyclical rabies variations.

  5. Patterns of fossil distributions within their environmental context from the Middle Triassic in South Canyon,Central Nevada,USA

    Institute of Scientific and Technical Information of China (English)

    Pedro; M.Monarrez; Nicole; Bonuso

    2014-01-01

    The Middle Triassic records the return of diverse marine communities after the severe effects of the end-Permian mass extinction.This diversification leads to the Mesozoic/modern adaptive radiation resulting in substantial changes in marine communities in comparison to their Paleozoic predecessors.This analysis focuses on the faunal abundance,ecological patterns,and environmental interpretation of a Middle Triassic section in Central Nevada.Twelve bulk samples were collected.Visible fossils were identified and tallied from hand samples and thin-sections were used to aid in environmental interpretation.Beginning in the Late Anisian,we observed an ammonoid dominated to flat-clam,epifaunal dominated benthic community within a muddy,quiet,inner shelf depositional environment.Through time,epifaunal bivalves dominate within a middle shelf environment followed by an increase in infaunalization and shell-thickness.During this time the presence of oncoids and the reported finding of corals suggest the middle shelf environment gave way to a higher energy patch reef shelf edge environment.Finally,we observe epifaunal brachiopods communities at the top of our section deposited in a middle shelf environment.In sum,we observe the dominance of modern taxa(i.e.,bivalves)with Paleozoic ecologies(i.e.,epifaunal),followed by the dominance of modern taxa with Modern ecologies(i.e.,infaunal,thick shells)and then a return to Paleozoic taxa(i.e.,brachiopods)and Paleozoic ecologies within an overall transgressive environment.

  6. Mixed Methods Case Study of Generational Patterns in Responses to Shame and Guilt

    Science.gov (United States)

    Ng, Tony

    2013-01-01

    Moral socialization and moral learning are antecedents of moral motivation. As many as 4 generations interact in workplace and education settings; hence, a deeper understanding of the moral motivation of members of those generations is needed. The purpose of this convergent mixed methods case study was to understand the moral motivation of 5…

  7. Spatio-Temporal Stochastic Pattern Generator for ensemble prediction and ensemble data assimilation in geophysical applications

    CERN Document Server

    Tsyrulnikov, Michael

    2016-01-01

    A generator of spatio-temporal pseudo-random Gaussian fields that satisfy the "proportionality of scales" property (Tsyroulnikov 2001) is presented. The generator is a third-order in time stochastic differential equation with a pseudo-differential spatial operator defined on a limited area domain in Cartesian coordinate system. The spatial covariance functions of the generated fields belong to the Mat\\'ern class. The spatio-temporal covariances are non-separable. A spectral-space numerical solver is implemented and accelerated exploiting properties of real-world geophysical fields, in particular, smoothness of their spatial spectra. The generator is designed to simulate additive or multiplicative, or other spatio-temporal perturbations that represent uncertainties in numerical prediction models in geophysics. The program code of the generator is publicly available.

  8. Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems

    Directory of Open Access Journals (Sweden)

    Keizo eHirano

    2012-08-01

    Full Text Available The generation of complex neural circuits depends on the correct wiring of neurons with diverse individual characteristics. To understand the complexity of the nervous system, the molecular mechanisms for specifying the identity and diversity of individual neurons must be elucidated. The clustered protocadherins (Pcdh in mammals consist of approximately 50 Pcdh genes (Pcdh-α, Pcdh-β, and Pcdh-γ that encode cadherin-family cell surface adhesion proteins. Individual neurons express a random combination of Pcdh-α and Pcdh-γ, whereas the expression patterns for the Pcdh-β genes, 22 one-exon genes in mouse, are not fully understood. Here we show that the Pcdh-β genes are expressed in a 3’-polyadenylated form in mouse brain. In situ hybridization using a pan-Pcdh-β probe against a conserved Pcdh-β sequence showed widespread labeling in the brain, with prominent signals in the olfactory bulb, hippocampus, and cerebellum. In situ hybridization with specific probes for individual Pcdh-β genes showed their expression to be scattered in Purkinje cells from P10 to P150. The scattered expression patterns were confirmed by performing a newly developed single-cell 3’-RACE analysis of Purkinje cells, which clearly demonstrated that the Pcdh-β genes are expressed monoallelically and combinatorially in individual Purkinje cells. Scattered expression patterns of individual Pcdh-β genes were also observed in pyramidal neurons in the hippocampus and cerebral cortex, neurons in the trigeminal and dorsal root ganglion, GABAergic interneurons, and cholinergic neurons. Our results extend previous observations of diversity at the single-neuron level generated by Pcdh expression and suggest that the Pcdh-β cluster genes contribute to specifying the identity and diversity of individual neurons.

  9. SARAPAN—A Simulated-Annealing-Based Tool to Generate Random Patterned-Channel-Age in CANDU Fuel Management Analyses

    Directory of Open Access Journals (Sweden)

    Doddy Kastanya

    2017-02-01

    Full Text Available In any reactor physics analysis, the instantaneous power distribution in the core can be calculated when the actual bundle-wise burnup distribution is known. Considering the fact that CANDU (Canada Deuterium Uranium utilizes on-power refueling to compensate for the reduction of reactivity due to fuel burnup, in the CANDU fuel management analysis, snapshots of power and burnup distributions can be obtained by simulating and tracking the reactor operation over an extended period using various tools such as the *SIMULATE module of the Reactor Fueling Simulation Program (RFSP code. However, for some studies, such as an evaluation of a conceptual design of a next-generation CANDU reactor, the preferred approach to obtain a snapshot of the power distribution in the core is based on the patterned-channel-age model implemented in the *INSTANTAN module of the RFSP code. The objective of this approach is to obtain a representative snapshot of core conditions quickly. At present, such patterns could be generated by using a program called RANDIS, which is implemented within the *INSTANTAN module. In this work, we present an alternative approach to derive the patterned-channel-age model where a simulated-annealing-based algorithm is used to find such patterns, which produce reasonable power distributions.

  10. The Identification of Discriminating Patterns from 16S rRNA Gene to Generate Signature for Bacillus Genus.

    Science.gov (United States)

    More, Ravi P; Purohit, Hemant J

    2016-08-01

    The 16S ribosomal RNA (16S rRNA) gene has been widely used for the taxonomic classification of bacteria. A molecular signature is a set of nucleotide patterns, which constitute a regular expression that is specific to each particular taxon. Our main goal was to identify discriminating nucleotide patterns in 16S rRNA gene and then to generate signatures for taxonomic classification. To demonstrate our approach, we used the phylum Firmicutes as a model using representative taxa Bacilli (class), Bacillales (order), Bacillaceae (family), and Bacillus (genus), according to their dominance at each hierarchical taxonomic level. We applied combined composite vector and multiple sequence alignment approaches to generate gene-specific signatures. Further, we mapped all the patterns into the different hypervariable regions of 16S rRNA gene and confirmed the most appropriate distinguishing region as V3-V4 for targeted taxa. We also examined the evolution in discriminating patterns of signatures across taxonomic levels. We assessed the comparative classification accuracy of signatures with other methods (i.e., RDP Classifier, KNN, and SINA). Results revealed that the signatures for taxa Bacilli, Bacillales, Bacillaceae, and Bacillus could correctly classify isolate sequences with sensitivity of 0.99, 0.97, 0.94, and 0.89, respectively, and specificity close to 0.99. We developed signature-based software DNA Barcode Identification (DNA BarID) for taxonomic classification that is available at website http://www.neeri.res.in/DNA_BarID.htm . This pattern-based study provides a deeper understanding of taxon-specific discriminating patterns in 16S rRNA gene with respect to taxonomic classification.

  11. Generation of a reference radiation pattern of string instruments using automatic excitation and acoustic centering.

    Science.gov (United States)

    Shabtai, Noam R; Behler, Gottfried; Vorländer, Michael

    2015-11-01

    Radiation patterns of musical instruments are important for the understanding of music perception in concert halls, and may be used to improve the plausibility of virtual acoustic systems. Many attempts have been performed to measure the spatial response of musical instruments using surrounding spherical microphone arrays with a limited number of microphones. This work presents a high-resolution spatial sampling of the radiation pattern of an electrically excited violin, and addresses technical problems that arise due to mechanical reasons of the excitation apparatus using acoustic centering.

  12. Near-field to far-field characterization of speckle patterns generated by disordered nanomaterials.

    Science.gov (United States)

    Parigi, Valentina; Perros, Elodie; Binard, Guillaume; Bourdillon, Céline; Maître, Agnès; Carminati, Rémi; Krachmalnicoff, Valentina; De Wilde, Yannick

    2016-04-04

    We study the intensity spatial correlation function of optical speckle patterns above a disordered dielectric medium in the multiple scattering regime. The intensity distributions are recorded by scanning near-field optical microscopy (SNOM) with sub-wavelength spatial resolution at variable distances from the surface in a range which spans continuously from the near-field (distance ≪ λ) to the far-field regime (distance ≫ λ). The non-universal behavior at sub-wavelength distances reveals the connection between the near-field speckle pattern and the internal structure of the medium.

  13. Near-field to far-field characterization of speckle patterns generated by disordered nanomaterials

    CERN Document Server

    Parigi, Valentina; Binard, Guillaume; Bourdillon, Céline; Maître, Agnès; Carminati, Rémi; Krachmalnicoff, Valentina; De Wilde, Yannick

    2016-01-01

    We study the intensity spatial correlation function of optical speckle patterns above a disordered dielectric medium in the multiple scattering regime. The intensity distributions are recorded by scanning near-field optical microscopy (SNOM) with sub-wavelength spatial resolution at variable distances from the surface in a range which spans continuously from the near-field (distance $ \\ll \\lambda $) to the far-field regime (distance $\\gg \\lambda $). The non-universal behavior at sub-wavelength distances reveals the connection between the near-field speckle pattern and the internal structure of the medium.

  14. Impact of cercal air currents on singing motor pattern generation in the cricket (Gryllus bimaculatus DeGeer).

    Science.gov (United States)

    Jacob, Pedro F; Hedwig, Berthold

    2015-11-01

    The cercal system of crickets detects low-frequency air currents produced by approaching predators and self-generated air currents during singing, which may provide sensory feedback to the singing motor network. We analyzed the effect of cercal stimulation on singing motor pattern generation to reveal the response of a singing interneuron to predator-like signals and to elucidate the possible role of self-generated air currents during singing. In fictive singing males, we recorded an interneuron of the singing network while applying air currents to the cerci; additionally, we analyzed the effect of abolishing the cercal system in freely singing males. In fictively singing crickets, the effect of short air stimuli is either to terminate prematurely or to lengthen the interchirp interval, depending on their phase in the chirp cycle. Within our stimulation paradigm, air stimuli of different velocities and durations always elicited an inhibitory postsynaptic potential in the singing interneuron. Current injection in the singing interneuron elicited singing motor activity, even during the air current-evoked inhibitory input from the cercal pathway. The disruptive effects of air stimuli on the fictive singing pattern and the inhibitory response of the singing interneuron point toward the cercal system being involved in initiating avoidance responses in singing crickets, according to the established role of cerci in a predator escape pathway. After abolishing the activity of the cercal system, the timing of natural singing activity was not significantly altered. Our study provides no evidence that self-generated cercal sensory activity has a feedback function for singing motor pattern generation.

  15. Data Series Generation for CPS Plants Simulation; Generacion de Series para Simulacion de Centrales Termosolares

    Energy Technology Data Exchange (ETDEWEB)

    Ibanez, G.; Valenzuela, R. X.; Ramirez, L.; Polo, J.

    2014-02-01

    Due to the problems with the environment and other issues arising from the use of oil as the main source of energy, such as unstable politics and economics, there has been a growing interest in the development of alternative forms of energy over the last few years. In this field, the sun is a fundamental element, since any form of existing energy derives from it, directly or indirectly. Taking in to consideration all of these renewable energies, we have decided to focus on solar thermal energy, seeing as it will play a vital role in the future particularly in countries such as Spain that have great solar potential. Amid this form of renewable energy, the parabolic cylinder concentrator power plants are technologies with one of the most promising futures. Power plants with sufficient technological developments to compete with the other forms of energies and that have an extensive margin for improvement. These power plants are the subject of the investigations carried out in this project. This project will try to establish and standardize some of the necessary procedures for the process of data prior to the simulation of energy with these types of power plants. The final objective is to help create a regulation where all these procedures are gathered together, and one that can be used as a guide for future investigations on the viability of these power plants. To achieve this, this project is comprised of various phases where different necessary investigations will be carried out in order to define the different points of the regulation. Firstly, the different casuistries will be investigated when analyzing the behavior of the estimated input data. At this stage, the selected variable (global or direct radiation), as well as the procedure used for the generation of the Monthly Reference Value, will be taken in to account, differentiating it in to two different typologies. The best method for the adjustment of the estimated data obtained from the satellite images will

  16. High Flux Central Receivers of Molten Salts for the New Generation of Commercial Stand-Alone Solar Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Lata, J. M.; Rodriguez, M.; Alvarez de Lara, M.

    2006-07-01

    Molten salt technology represents nowadays the most cost-effective technology for electricity generation for stand-alone Solar Power Plants. Although this technology can be applied to both concentrating technologies, Parabolic TROUGH and Central Receiver Systems (CRS), CRS technology can take advantages from its high concentration, allowing to work at high temperatures and therefore with a reduction in the size and cost of the storage system. The Receiver System is the door for which the energy passes from the field collector to the thermal-electric cycle; it represents, therefore, the core of the CRS System. SENER and CIEMAT are joining forces to face up the challenge of sizing and designing a molten salt Receiver of high thermal efficiency, able to operate at high fluxes without compromising its durability (at least 25 years). The advances in design and studies of different materials, to operate at high fluxes using molten salts as heat transfer fluid, will be presented hereafter. (Author)

  17. Diversity and distribution patterns of the Oligocene and Miocene decapod crustaceans (Crustacea: Malacostraca) of the Western and Central Paratethys

    Science.gov (United States)

    Hyžný, Matúš

    2017-01-01

    Decapod associations have been significant components of marine habitats throughout the Cenozoic when the major diversification of the group occurred. In this respect, the circum-Mediterranean area is of particular interest due to its complex palaeogeographic history. During the Oligo-Miocene, it was divided in two major areas, Mediterranean and Paratethys. Decapod crustaceans from the Paratethys Sea have been reported in the literature since the 19th century, but only recent research advances allow evaluation of the diversity and distribution patterns of the group. Altogether 176 species-level taxa have been identified from the Oligocene and Miocene of the Western and Central Paratethys. Using the three-dimensional NMDS analysis, the composition of decapod crustacean faunas of the Paratethys shows significant differences through time. The Ottnangian and Karpatian decapod associations were similar to each other both taxonomically and in the mode of preservation, and they differed taxonomically from the Badenian ones. The Early Badenian assemblages also differed taxonomically from the Late Badenian ones. The time factor, including speciation, immigration from other provinces and/or (local or global) extinction, can explain temporal differences among assemblages within the same environment. High decapod diversity during the Badenian was correlated with the presence of reefal settings. The Badenian was the time with the highest decapod diversity, which can, however, be a consequence of undersampling of other time slices. Whereas the Ottnangian and Karpatian decapod assemblages are preserved virtually exclusively in the siliciclastic “Schlier”-type facies that originated in non-reefal offshore environments, carbonate sedimentation and the presence of reefal environments during the Badenian in the Central Paratethys promoted thriving of more diverse reef-associated assemblages. In general, Paratethyan decapods exhibited homogeneous distribution during the Oligo

  18. Diversity and distribution patterns of the Oligocene and Miocene decapod crustaceans (Crustacea: Malacostraca) of the Western and Central Paratethys

    Science.gov (United States)

    Hyžný, Matúš

    2016-10-01

    Decapod associations have been significant components of marine habitats throughout the Cenozoic when the major diversification of the group occurred. In this respect, the circum-Mediterranean area is of particular interest due to its complex palaeogeographic history. During the Oligo-Miocene, it was divided in two major areas, Mediterranean and Paratethys. Decapod crustaceans from the Paratethys Sea have been reported in the literature since the 19th century, but only recent research advances allow evaluation of the diversity and distribution patterns of the group. Altogether 176 species-level taxa have been identified from the Oligocene and Miocene of the Western and Central Paratethys. Using the three-dimensional NMDS analysis, the composition of decapod crustacean faunas of the Paratethys shows significant differences through time. The Ottnangian and Karpatian decapod associations were similar to each other both taxonomically and in the mode of preservation, and they differed taxonomically from the Badenian ones. The Early Badenian assemblages also differed taxonomically from the Late Badenian ones. The time factor, including speciation, immigration from other provinces and/or (local or global) extinction, can explain temporal differences among assemblages within the same environment. High decapod diversity during the Badenian was correlated with the presence of reefal settings. The Badenian was the time with the highest decapod diversity, which can, however, be a consequence of undersampling of other time slices. Whereas the Ottnangian and Karpatian decapod assemblages are preserved virtually exclusively in the siliciclastic "Schlier"-type facies that originated in non-reefal offshore environments, carbonate sedimentation and the presence of reefal environments during the Badenian in the Central Paratethys promoted thriving of more diverse reef-associated assemblages. In general, Paratethyan decapods exhibited homogeneous distribution during the Oligo

  19. Newly-generated Daliangshan Fault Zone—Shortcutting on the central section of Xianshuihe-Xiaojiang fault system

    Institute of Scientific and Technical Information of China (English)

    IKEDA; Yasutaka; TOGO; Masayoshi; TAJIKARA; Masayoshi; ECHIGO; Tomoo; OKADA; Shinsuke

    2008-01-01

    The Daliangshan fault zone is the eastern branch in the central section of Xianshuihe-Xiaojiang fault system. It has been neglected for a long time, partly because of no destructive earthquake records along this fault zone. On the other hand, it is located on the remote and inaccessible plateau. So far it was excluded as part of the Xianshuihe-Xiaojiang fault system. Based on the interpretation of aerophotographs and field investigations, we document this fault zone in detail, and give an estimation of strike-slip rate about 3 mm/a in Late Quaternary together with age dating data. The results suggest that the Daliangshan fault zone is a newly-generated fault zone resulted from shortcutting in the central section of Xianshuihe-Xiaojiang fault system because of the clockwise rotation of the Southeastern Tibetan Crustal Block, which is bounded by the Xianshuihe-Xiaojiang fault system. Moreover, the shortcutting may make the Daliangshan fault zone replace the Anninghe and Zemuhe fault zones gradually, and finally, the later two fault zones will probably die out with the continuous clockwise rotation.

  20. Changes in muscle activation and force generation patterns during cycling movements because of low-intensity squat training with slow movement and tonic force generation.

    Science.gov (United States)

    Tanimoto, Michiya; Arakawa, Hiroshi; Sanada, Kiyoshi; Miyachi, Motohiko; Ishii, Naokata

    2009-11-01

    Our previous studies showed that relatively low-load (approximately 50-60% 1 repetition maximum [1RM]) resistance training with slow movement and tonic force generation (LST) significantly increased muscle size and strength. However, LST is a very specific movement that differs from natural movements associated with sport activities and activities of daily life, and therefore, it might have some unfavorable effects on dynamic sport movement. We investigated the effects of LST on muscle activity and force generation patterns during cycling movement as a representative dynamic sports movement. Twenty-four healthy young men who were not in the habit of bicycle riding and did not have a history of regular resistance training were randomly assigned to the LST (approximately 60% 1RM load, 3-second lifting, and 3-second lowering movement without a relaxing phase: n = 8), a high-intensity exercise at normal speed (HM) group (85% 1RM load, 1-second lifting, 1-second lowering, and 1-second relaxed movement: n = 8), or sedentary control (CON, n = 8) group. Subjects in the training groups performed vertical squats by the assigned method. Exercise sessions consisted of 3 sets and were performed twice a week for 13 weeks. Pre- and posttraining muscle activation and force generation patterns during the cycling movements were evaluated by the coefficient of variation (CV) of the rectified electromyographic (EMG) wave from the vastus lateralis and CV of pedaling force. Both the CV of the rectified EMG and of pedaling force decreased significantly in the LST group (-21 and -18%, p < 0.05, respectively), whereas there were no significant changes in either the HN or the CON group. This decrease in CV in the LST group could mean that muscle activity and force generation during cycling movement have become more tonic. This result following LST may have an unfavorable effect on cycling movement and other dynamic sports movements.

  1. Stereo transparency in ambiguous stereograms generated by overlapping two identical dot patterns.

    Science.gov (United States)

    Watanabe, Osamu

    2009-11-30

    In binocular vision, observers can perceive transparent surfaces by fusing a stereogram composed of two overlapping patterns with different disparities. When dot patterns of two surfaces are identical, the stereogram has potential matches leading to both transparency and non-transparency (or unitary surface) perceptions. However, these two matching candidates are exclusive if the uniqueness assumption holds. This stereogram can be regarded as a random-dot version of the double-nail illusion and a stereo version of the locally paired-dot stimulus that was used to investigate the neural mechanism for motion transparency. Which surface is perceived in this ambiguous stereogram would reflect the property of the transparency detection mechanism in human stereopsis. Here we perform a parametric study to examine the perceptual property in this ambiguous stereogram. The result showed that the ability in transparency detection from this stereogram is determined by the contrast reversal ratio between overlapping patterns within small regions the width of which was about 0.4 deg. The width was similar to the receptive field sizes of neurons in striate cortex. The result suggests that the contrast reversal between two identical patterns would modulate activities of binocular neurons, and this modification gives a crucial effect on the neural representation for overlapping disparities.

  2. A column generation-based heuristic for rostering with work patterns

    DEFF Research Database (Denmark)

    Lusby, Richard Martin; Dohn, Anders Høeg; Range, Troels Martin

    2012-01-01

    This paper addresses the Ground Crew Rostering Problem with Work Patterns, an important manpower planning problem arising in the ground operations of airline companies. We present a cutting stock-based integer programming formulation of the problem and describe a powerful heuristic decomposition...

  3. Infant dietary patterns and bone mass in childhood: the Generation R Study

    NARCIS (Netherlands)

    E.H. van den Hooven (Edith); D.H.M. Heppe (Denise); J.C. Kiefte-de Jong (Jessica); M.C. Medina-Gomez (Carolina); H.A. Moll (Henriëtte); A. Hofman (Albert); V.W.V. Jaddoe (Vincent); F. Rivadeneira Ramirez (Fernando); O.H. Franco (Oscar)

    2015-01-01

    textabstractConclusions: An infant dietary pattern characterized by high intakes of dairy and cheese, whole grains, and eggs is positively associated with bone development in childhood. Further research is needed to investigate the consequences for bone health in later life.Results: Higher adherence

  4. Characterization methods of nano-patterned surfaces generated by induction heating assisted injection molding

    DEFF Research Database (Denmark)

    Tang, Peter Torben; Ravn, Christian; Menotti, Stefano

    2015-01-01

    An induction heating-assisted injection molding (IHAIM) process developed by the authors is used to replicate surfaces containing random nano-patterns. The injection molding setup is developed so that an induction heating system rapidly heats the cavity wall at rates of up to 10◦C/s. In order to ...

  5. Patterns of Lynx Predation at the Interface between Protected Areas and Multi-Use Landscapes in Central Europe.

    Directory of Open Access Journals (Sweden)

    Elisa Belotti

    Full Text Available In Central Europe, protected areas are too small to ensure survival of populations of large carnivores. In the surrounding areas, these species are often persecuted due to competition with game hunters. Therefore, understanding how predation intensity varies spatio-temporally across areas with different levels of protection is fundamental. We investigated the predation patterns of Eurasian lynx (Lynx lynx on roe deer (Capreolus capreolus and red deer (Cervus elaphus in both protected areas and multi-use landscapes of the Bohemian Forest Ecosystem. Based on 359 roe and red deer killed by 10 GPS-collared lynx, we calculated the species-specific annual kill rates and tested for effects of season and lynx age, sex and reproductive status. Because roe and red deer in the study area concentrate in unprotected lowlands during winter, we modeled spatial distribution of kills separately for summer and winter and calculated-the probability of a deer killed by lynx and-the expected number of kills for areas with different levels of protection. Significantly more roe deer (46.05-74.71/year/individual lynx were killed than red deer (1.57-9.63/year/individual lynx, more deer were killed in winter than in summer, and lynx family groups had higher annual kill rates than adult male, single adult female and subadult female lynx. In winter the probability of a deer killed and the expected number of kills were higher outside the most protected part of the study area than inside; in summer, this probability did not differ between areas, and the expected number of kills was slightly larger inside than outside the most protected part of the study area. This indicates that the intensity of lynx predation in the unprotected part of the Bohemian Forest Ecosystem increases in winter, thus mitigation of conflicts in these areas should be included as a priority in the lynx conservation strategy.

  6. Short episodes of crust generation during protracted accretionary processes: Evidence from Central Asian Orogenic Belt, NW China

    Science.gov (United States)

    Tang, Gong-Jian; Chung, Sun-Lin; Hawkesworth, Chris J.; Cawood, P. A.; Wang, Qiang; Wyman, Derek A.; Xu, Yi-Gang; Zhao, Zhen-Hua

    2017-04-01

    Accretionary orogens are major sites of generation of continental crust but the spatial and temporal distribution of crust generation within individual orogens remains poorly constrained. Paleozoic (∼540-270 Ma) granitic rocks from the Alati, Junggar and Chinese Tianshan segments of the Central Asian Orogenic Belt (CAOB) have markedly bimodal age frequency distributions with peaks of ages at ∼400 Ma and 280 Ma for the Altai segment, and ∼430 Ma and 300 Ma for the Junggar and Chinese Tianshan segments. Most of the magma was generated in short time intervals (∼20-40 Ma), and variations in magma volumes and in Nd-Hf isotope ratios are taken to reflect variable rates of new crust generation within a long-lived convergent plate setting. The Junggar segment is characterized by high and uniform Nd-Hf isotope ratios (εNd (t) = + 5 to + 8; zircon εHf (t) = + 10 to + 16) and it appears to have formed in an intra-oceanic arc system. In the Altai and Chinese Tianshan segments, the Nd-Hf isotope ratios (εNd (t) = - 7 to + 8; zircon εHf (t) = - 16 to + 16) are lower, although they increase with decreasing age of the rock units. The introduction of a juvenile component into the Chinese Tianshan and Altai granitic rocks appears to have occurred in continental arc settings and it reflects a progressive reduction in the contributions from old continental lower crust and lithospheric mantle. Within the long-lived convergent margin setting (over ∼200 Ma), higher volumes of magma, and greater contributions of juvenile material, were typically emplaced over short time intervals of ∼20-40 Ma. These intervals were associated with higher Nb/La ratios, coupled with lower La/Yb ratios, in both the mafic and granitic rocks, and these episodes of increased magmatism from intraplate-like sources are therefore thought to have been in response to lithospheric extension. The trace element and Nd-Hf isotope data, in combination with estimates of granitic magma volumes, highlight

  7. Sustainability Assessment of a Self-Consumption Wood-Energy Chain on Small Scale for Heat Generation in Central Italy

    Directory of Open Access Journals (Sweden)

    Stefano Verani

    2015-06-01

    Full Text Available The sustainability of a small-scale self-consumption wood-energy chain for heat generation in central Italy was analyzed from a technical, economic and energetic point of view. A micro-chain was developed within the CRA-ING farm at Monterotondo (Rome, Italy: The purpose of this system was to produce biomass for supplying a heating plant within the CRA-ING property as a substitute for diesel fuel. A poplar short rotation coppice, established with clones AF2, AF6 and Monviso, fed the micro-chain. The rotation was biennial. The average plantation production (Mgd.m.·ha−1·year−1 was 10.2, with a maximum of 13.53 for the twin-rows AF2 and a minimum of 8.00 for the single-row Monviso. The economic assessment was based on the Net Present Value (NPV method and the equivalent annuity cost, and found an average saving of 15.60 €·GJ−1 of heat generated by the wood chips heating system in comparison with the diesel heating system over a 10 year lifetime of the thermal power plant. The energy assessment of the poplar plantation, carried out using the Gross Energy Requirements method, reported an energy output/input ratio of 12.3. The energy output/input ratio of the whole micro-chain was 4.5.

  8. Differential proliferation rates generate patterns of mechanical tension that orient tissue growth

    OpenAIRE

    2013-01-01

    Orientation of cell divisions is a key mechanism of tissue morphogenesis. In the growing Drosophila wing imaginal disc epithelium, most of the cell divisions in the central wing pouch are oriented along the proximal–distal (P–D) axis by the Dachsous-Fat-Dachs planar polarity pathway. However, cells at the periphery of the wing pouch instead tend to orient their divisions perpendicular to the P–D axis despite strong Dachs polarization. Here, we show that these circumferential divisions are ori...

  9. Parallel streams versus integrated timing in multilimb pattern generation: A test of Korte's Third Law.

    Science.gov (United States)

    Jagacinski, Richard J; Rizzi, Emanuele; Kim, Tae Hoon; Lavender, Steven A; Speller, Lassiter F; Klapp, Stuart T

    2016-11-01

    Skilled drummers performed a 4:3:2 polyrhythm with 2 hands and 1 foot. For each pair of limbs patterns of temporal covariation were used to infer relatively independent parallel streams versus integrated timing relationships. Parallel timing was more prevalent between hand and foot than between the 2 hands, and parallel timing generally increased with tapping rate. Different combinations of integrated and parallel timing were found among the 3 limbs. A second experiment used a wider range of tapping rates and explored 3:2 tapping with 2 hands, 2 feet, or hand and foot. The latter 2 limb pairs resulted in greater prevalence of parallel timing. These results can be interpreted in terms of a Gestalt principle of grouping known as Korte's Third Law, which can be extended from the perceptual domain to the perceptual-motor domain. This principle indicates that perceived velocity is a key factor in determining whether a sequence of events is represented as a single integrated pattern or as multiple parallel patterns. The present results put disparate previous findings on bimanual polyrhythmic tapping and rhythmic aspects of the golf swing under a common theoretical perspective. (PsycINFO Database Record

  10. Programming Surface Energy Driven Marangoni Convection in Polymer Thin Films to Generate Topographic Patterns

    Science.gov (United States)

    Kim, Chae Bin; Janes, Dustin; Arshad, Talha; Katzenstein, Joshua; Prisco, Nathan; McGuffin, Dana; Bonnecaze, Roger; Ellison, Christopher

    2015-03-01

    The Marangoni effect describes how fluid flows in response to gradients in surface energy. We recently developed a method for photochemically preprograming spatial surface energy patterns in glassy polystyrene (PS) thin films. UV irradiation through a mask selectively dehydrogenates the PS, thus increasing surface energy in the UV exposed regions compared to the unexposed regions. After heating the film to the liquid state, transport of polymer occurs from regions of low surface energy to regions of high surface energy. This method can be harnessed to rapidly manufacture polymer films possessing prescribed three-dimensional topographies reflective of the original light exposure pattern. To quantify and verify this phenomenon, a theoretical model that gives a more thorough understanding of the physics of this process, its limits and ways to apply it efficiently for various target metrics will also be presented along with comparisons between theoretical predictions and experimental observations. Finally, while PS dehydrogenation can be used to produce a variety of topographical patterns, judicious selection of the photosensitizing compounds in an otherwise transparent polymer expands the use of this method to more readily available light sources.

  11. Consumption patterns and household hazardous solid waste generation in an urban settlement in México.

    Science.gov (United States)

    Otoniel, Buenrostro Delgado; Liliana, Márquez-Benavides; Francelia, Pinette Gaona

    2008-01-01

    Mexico is currently facing a crisis in the waste management field. Some efforts have just commenced in urban and in rural settlements, e.g., conversion of open dumps into landfills, a relatively small composting culture, and implementation of source separation and plastic recycling strategies. Nonetheless, the high heterogeneity of components in the waste, many of these with hazardous properties, present the municipal collection services with serious problems, due to the risks to the health of the workers and to the impacts to the environment as a result of the inadequate disposition of these wastes. A generation study in the domestic sector was undertaken with the aim of finding out the composition and the generation rate of household hazardous waste (HHW) produced at residences. Simultaneously to the generation study, a socioeconomic survey was applied to determine the influence of income level on the production of HHW. Results from the solid waste generation analysis indicated that approximately 1.6% of the waste stream consists of HHW. Correspondingly, it was estimated that in Morelia, a total amount of 442ton/day of domestic waste are produced, including 7.1ton of HHW per day. Furthermore, the overall amount of HHW is not directly related to income level, although particular byproducts do correlate. However, an important difference was observed, as the brands and the presentation sizes of goods and products used in each socioeconomic stratum varied.

  12. Exact distribution of a pattern in a set of random sequences generated by a Markov source: applications to biological data

    Directory of Open Access Journals (Sweden)

    Regad Leslie

    2010-01-01

    Full Text Available Abstract Background In bioinformatics it is common to search for a pattern of interest in a potentially large set of rather short sequences (upstream gene regions, proteins, exons, etc.. Although many methodological approaches allow practitioners to compute the distribution of a pattern count in a random sequence generated by a Markov source, no specific developments have taken into account the counting of occurrences in a set of independent sequences. We aim to address this problem by deriving efficient approaches and algorithms to perform these computations both for low and high complexity patterns in the framework of homogeneous or heterogeneous Markov models. Results The latest advances in the field allowed us to use a technique of optimal Markov chain embedding based on deterministic finite automata to introduce three innovative algorithms. Algorithm 1 is the only one able to deal with heterogeneous models. It also permits to avoid any product of convolution of the pattern distribution in individual sequences. When working with homogeneous models, Algorithm 2 yields a dramatic reduction in the complexity by taking advantage of previous computations to obtain moment generating functions efficiently. In the particular case of low or moderate complexity patterns, Algorithm 3 exploits power computation and binary decomposition to further reduce the time complexity to a logarithmic scale. All these algorithms and their relative interest in comparison with existing ones were then tested and discussed on a toy-example and three biological data sets: structural patterns in protein loop structures, PROSITE signatures in a bacterial proteome, and transcription factors in upstream gene regions. On these data sets, we also compared our exact approaches to the tempting approximation that consists in concatenating the sequences in the data set into a single sequence. Conclusions Our algorithms prove to be effective and able to handle real data sets with

  13. Generation of Homogeneous and Patterned Electron Beams using a Microlens Array Laser-Shaping Technique

    Energy Technology Data Exchange (ETDEWEB)

    Halavanau, Aliaksei [NICADD, DeKalb; Edstrom, Dean [Fermilab; Gai, Wei [Argonne, HEP; Ha, Gwanghui [Argonne, HEP; Piot, Philippe [NICADD, DeKalb; Power, John [Argonne, HEP; Qiang, Gao [Unlisted, CN; Ruan, Jinhao [Fermilab; Santucci, James [Fermilab; Wisniewski, Eric [Argonne, HEP

    2016-06-01

    In photocathodes the achievable electron-beam parameters are controlled by the laser used to trigger the photoemission process. Non-ideal laser distribution hampers the final beam quality. Laser inhomogeneities, for instance, can be "amplified" by space-charge force and result in fragmented electron beams. To overcome this limitation laser shaping methods are routinely employed. In the present paper we demonstrate the use of simple microlens arrays to dramatically improve the transverse uniformity. We also show that this arrangement can be used to produce transversely-patterned electron beams. Our experiments are carried out at the Argonne Wakefield Accelerator facility.

  14. Static envelope patterns in composite resonances generated by level crossing in optical toroidal microcavities.

    Science.gov (United States)

    Carmon, Tal; Schwefel, Harald G L; Yang, Lan; Oxborrow, Mark; Stone, A Douglas; Vahala, Kerry J

    2008-03-14

    We study level crossing in the optical whispering-gallery (WG) modes by using toroidal microcavities. Experimentally, we image the stationary envelope patterns of the composite optical modes that arise when WG modes of different wavelengths coincide in frequency. Numerically, we calculate crossings of levels that correspond with the observed degenerate modes, where our method takes into account the not perfectly transverse nature of their field polarizations. In addition, we analyze anticrossing with a large avoidance gap between modes of the same azimuthal number.

  15. Automated Learning of Subcellular Variation among Punctate Protein Patterns and a Generative Model of Their Relation to Microtubules.

    Directory of Open Access Journals (Sweden)

    Gregory R Johnson

    2015-12-01

    Full Text Available Characterizing the spatial distribution of proteins directly from microscopy images is a difficult problem with numerous applications in cell biology (e.g. identifying motor-related proteins and clinical research (e.g. identification of cancer biomarkers. Here we describe the design of a system that provides automated analysis of punctate protein patterns in microscope images, including quantification of their relationships to microtubules. We constructed the system using confocal immunofluorescence microscopy images from the Human Protein Atlas project for 11 punctate proteins in three cultured cell lines. These proteins have previously been characterized as being primarily located in punctate structures, but their images had all been annotated by visual examination as being simply "vesicular". We were able to show that these patterns could be distinguished from each other with high accuracy, and we were able to assign to one of these subclasses hundreds of proteins whose subcellular localization had not previously been well defined. In addition to providing these novel annotations, we built a generative approach to modeling of punctate distributions that captures the essential characteristics of the distinct patterns. Such models are expected to be valuable for representing and summarizing each pattern and for constructing systems biology simulations of cell behaviors.

  16. Student-generated questions during chemistry lectures: Patterns, self-appraisals, and relations with motivational beliefs and achievement

    Science.gov (United States)

    Bergey, Bradley W.

    Self-generated questions are a central mechanism for learning, yet students' questions are often infrequent during classroom instruction. As a result, little is known about the nature of student questioning during typical instructional contexts such as listening to a lecture, including the extent and nature of student-generated questions, how students evaluate their questions, and the relations among questions, motivations, and achievement. This study examined the questions undergraduate students (N = 103) generated during 8 lectures in an introductory chemistry course. Students recorded and appraised their question in daily question logs and reported lecture-specific self-efficacy beliefs. Self-efficacy, personal interest, goal orientations, and other motivational self-beliefs were measured before and after the unit. Primary analyses included testing path models, multiple regressions, and latent class analyses. Overall, results indicated that several characteristics of student questioning during lectures were significantly related to various motivations and achievement. Higher end-of-class self-efficacy was associated with fewer procedural questions and more questions that reflected smaller knowledge deficits. Lower exam scores were associated with questions reflecting broader knowledge deficits and students' appraisals that their questions had less value for others than for themselves. Individual goal orientations collectively and positively predicted question appraisals. The questions students generated and their relations with motivational variables and achievement are discussed in light of the learning task and academic context.

  17. Pattern Matching of Harmonic Vibrations in Nonlinearly Generated Acoustic Modes in Bovine Bone Samples

    Science.gov (United States)

    Alippi, A.; Biagioni, A.; Germano, M.; Passeri, D.

    2008-06-01

    Local probing of nonlinear generation of harmonic vibrations has been done on bone plate samples and the evaluation of the nonlinear term is derived from a limited number of cases of bovine thigh bones, that shows that a low level of nonlinearity is present in bone structures. This is consistent with the assumption that in low level nonlinear samples the distribution of harmonic vibrations matches the corresponding power distribution of the fundamental mode.

  18. Streamwise counter-rotating vortices generated by triangular leading edge pattern in flat plate boundary layer

    KAUST Repository

    Hasheminejad, S. M.

    2016-01-05

    A series of flow visualizations were conducted to qualitatively study the development of streamwise counter-rotating vortices over a flat plate induced by triangular patterns at the leading edge of a flat plate. The experiments were carried out for a Reynolds number based on the pattern wavelength (λ) of 3080. The results depict the onset, development and breakdown of the vortical structures within the flat plate boundary layer. Moreover, the effect of one spanwise array of holes with diameter of 0.2λ (=3 mm) was examined. This investigation was done on two different flat plates with holes placed at the location x/λ = 2 downstream of the troughs and peaks. The presence of holes after troughs does not show any significant effect on the vortical structures. However, the plate with holes after peaks noticeably delays the vortex breakdown. In this case, the “mushroom-like” vortices move away from the wall and propagate downstream with stable vortical structures. The vortex growth is halted further downstream but start to tilt aside.

  19. Synaptic signal streams generated by ex vivo neuronal networks contain non-random, complex patterns.

    Science.gov (United States)

    Lee, Sangmook; Zemianek, Jill M; Shultz, Abraham; Vo, Anh; Maron, Ben Y; Therrien, Mikaela; Courtright, Christina; Guaraldi, Mary; Yanco, Holly A; Shea, Thomas B

    2014-11-01

    Cultured embryonic neurons develop functional networks that transmit synaptic signals over multiple sequentially connected neurons as revealed by multi-electrode arrays (MEAs) embedded within the culture dish. Signal streams of ex vivo networks contain spikes and bursts of varying amplitude and duration. Despite the random interactions inherent in dissociated cultures, neurons are capable of establishing functional ex vivo networks that transmit signals among synaptically connected neurons, undergo developmental maturation, and respond to exogenous stimulation by alterations in signal patterns. These characteristics indicate that a considerable degree of organization is an inherent property of neurons. We demonstrate herein that (1) certain signal types occur more frequently than others, (2) the predominant signal types change during and following maturation, (3) signal predominance is dependent upon inhibitory activity, and (4) certain signals preferentially follow others in a non-reciprocal manner. These findings indicate that the elaboration of complex signal streams comprised of a non-random distribution of signal patterns is an emergent property of ex vivo neuronal networks.

  20. Temporal patterns of rat behaviour in the central platform of the elevated plus maze. Comparative analysis between male subjects of strains with different basal levels of emotionality.

    Science.gov (United States)

    Casarrubea, M; Faulisi, F; Caternicchia, F; Santangelo, A; Di Giovanni, G; Benigno, A; Magnusson, M S; Crescimanno, G

    2016-08-01

    We have analyzed the temporal patterns of behaviour of male rats of the Wistar and DA/Han strains on the central platform of the elevated plus maze. The ethogram encompassed 10 behavioural elements. Durations, frequencies and latencies showed quantitative differences as to walking and sniffing activities. Wistar rats displayed significantly lower latency and significantly higher durations and frequencies of walking activities. DA/Han rats showed a significant increase of sniffing duration. In addition, DA/Han rats showed a significantly higher amount of time spent in the central platform. Multivariate T-pattern analysis revealed differences in the temporal organization of behaviour of the two rat strains. DA/Han rats showed (a) higher behavioural complexity and variability and (b) a significantly higher mean number of T-patterns than Wistar rats. Taken together, T-pattern analysis of behaviour in the centre of the elevated plus maze can noticeably improve the detection of subtle features of anxiety related behaviour. We suggest that T-pattern analysis could be used as sensitive tool to test the action of anxiolytic and anxiogenic manipulations.

  1. THE SPATIAL PATTERN OF URBANIZATION AND SMALL CITIES DEVELOPMENT IN CENTRAL JAVA: A CASE STUDY OF SEMARANG-YOGYAKARTA-SURAKARTA REGION

    Directory of Open Access Journals (Sweden)

    Jawoto Sih Setyono

    2016-04-01

    Full Text Available The special form of urbanization in Indonesia has led to a variety of themes on the urban development studies in Indonesia. Since 1990s, there has been an emphasis on the development of mega-urban regions, particularly those surrounding Jakarta as the biggest and the prime city in Indonesia. This research is aimed at elaborating the previous knowledge on the urbanization pattern in Indonesia, and Java in particular. More specifically, this study examines urban development trend in Central Java. The analysis of urbanization in this study can be classified into two categories, i.e. analysis of the urbanization level and analysis of the urbanization growth. These two analyses are combined by applying some GIS methods in order to understand the pattern of urbanization in the region. It is found that the urbanization process in Central Java has transformed the predominantly rural regions in the 1980s into the urban ones. The rapid growth of urban population forms some observable pattern that may be different to the national pattern. There are common spatial patterns, such as the importance of the coastal region and the essential role of the larger urban centers in the urbanization. In this regards, the emergence of the smaller centers has also contributed to the process, especially in bridging a more balanced development between major urban centers and their respective rural hinterland.

  2. Temporal and spatial patterns in wind stress and wind stress curl over the central Southern California Bight

    Science.gov (United States)

    Noble, Marlene A.; Rosenberger, Kurt J.; Rosenfeld, Leslie K.; Robertson, George L.

    2012-01-01

    In 2001, the U.S. Geological Survey, together with several other federal and municipal agencies, began a series of field programs to determine along and cross-shelf transport patterns over the continental shelves in the central Southern California Bight. As a part of these programs, moorings that monitor winds were deployed off the Palos Verdes peninsula and within San Pedro Bay for six 3–4 month summer and winter periods between 2001 and 2008. In addition, nearly continuous records of winds for this 7-year period were obtained from a terrestrial site at the coast and from a basin site offshore of the long-term coastal site. The mean annual winds are downcoast at all sites. The alongshelf components of wind stress, which are the largest part of the low-frequency wind stress fields, are well correlated between basin, shelf and coastal sites. On average, the amplitude of alongshelf fluctuations in wind stress are 3–4 times larger over the offshore basin, compared to the coastal site, irrespective of whether the fluctuations represent the total, or just the correlated portion of the wind stress field. The curl in the large-scale wind stress tends to be positive, especially in the winter season when the mean wind stress is downcoast and larger at the offshore basin site than at the beach. However, since the fluctuation in wind stress amplitudes are usually larger than the mean, periods of weak negative curl do occur, especially in the summer season when the largest normalized differences in the amplitude of wind stress fluctuations are found in the nearshore region of the coastal ocean. Even though the low-frequency wind stress field is well-correlated over the continental shelf and offshore basins, out to distances of 35 km or more from the coast, winds even 10 km inshore of the beach do not represent the coastal wind field, at least in the summer months. The seasonal changes in the spatial structures in wind stress amplitudes suggest that an assessment of the

  3. Elucidating the role of topological pattern discovery and support vector machine in generating predictive models for Indian summer monsoon rainfall

    Science.gov (United States)

    Chattopadhyay, Manojit; Chattopadhyay, Surajit

    2016-10-01

    The present paper reports a study, where growing hierarchical self-organising map (GHSOM) has been applied to achieve a visual cluster analysis to the Indian rainfall dataset consisting of 142 years of Indian rainfall data so that the yearly rainfall can be segregated into small groups to visualise the pattern of clustering behaviour of yearly rainfall due to changes in monthly rainfall for each year. Also, through support vector machine (SVM), it has been observed that generation of clusters impacts positively on the prediction of the Indian summer monsoon rainfall. Results have been presented through statistical and graphical analyses.

  4. Simple process-based simulators for generating spatial patterns of habitat loss and fragmentation: a review and introduction to the G-RaFFe model.

    Science.gov (United States)

    Pe'er, Guy; Zurita, Gustavo A; Schober, Lucia; Bellocq, Maria I; Strer, Maximilian; Müller, Michael; Pütz, Sandro

    2013-01-01

    Landscape simulators are widely applied in landscape ecology for generating landscape patterns. These models can be divided into two categories: pattern-based models that generate spatial patterns irrespective of the processes that shape them, and process-based models that attempt to generate patterns based on the processes that shape them. The latter often tend toward complexity in an attempt to obtain high predictive precision, but are rarely used for generic or theoretical purposes. Here we show that a simple process-based simulator can generate a variety of spatial patterns including realistic ones, typifying landscapes fragmented by anthropogenic activities. The model "G-RaFFe" generates roads and fields to reproduce the processes in which forests are converted into arable lands. For a selected level of habitat cover, three factors dominate its outcomes: the number of roads (accessibility), maximum field size (accounting for land ownership patterns), and maximum field disconnection (which enables field to be detached from roads). We compared the performance of G-RaFFe to three other models: Simmap (neutral model), Qrule (fractal-based) and Dinamica EGO (with 4 model versions differing in complexity). A PCA-based analysis indicated G-RaFFe and Dinamica version 4 (most complex) to perform best in matching realistic spatial patterns, but an alternative analysis which considers model variability identified G-RaFFe and Qrule as performing best. We also found model performance to be affected by habitat cover and the actual land-uses, the latter reflecting on land ownership patterns. We suggest that simple process-based generators such as G-RaFFe can be used to generate spatial patterns as templates for theoretical analyses, as well as for gaining better understanding of the relation between spatial processes and patterns. We suggest caution in applying neutral or fractal-based approaches, since spatial patterns that typify anthropogenic landscapes are often non

  5. Time-resolved measurements with streaked diffraction patterns from electrons generated in laser plasma wakefield

    Science.gov (United States)

    He, Zhaohan; Nees, John; Hou, Bixue; Krushelnick, Karl; Thomas, Alec; Beaurepaire, Benoît; Malka, Victor; Faure, Jérôme

    2013-10-01

    Femtosecond bunches of electrons with relativistic to ultra-relativistic energies can be robustly produced in laser plasma wakefield accelerators (LWFA). Scaling the electron energy down to sub-relativistic and MeV level using a millijoule laser system will make such electron source a promising candidate for ultrafast electron diffraction (UED) applications due to the intrinsic short bunch duration and perfect synchronization with the optical pump. Recent results of electron diffraction from a single crystal gold foil, using LWFA electrons driven by 8-mJ, 35-fs laser pulses at 500 Hz, will be presented. The accelerated electrons were collimated with a solenoid magnetic lens. By applying a small-angle tilt to the magnetic lens, the diffraction pattern can be streaked such that the temporal evolution is separated spatially on the detector screen after propagation. The observable time window and achievable temporal resolution are studied in pump-probe measurements of photo-induced heating on the gold foil.

  6. Entropy-based generation of supervised neural networks for classification of structured patterns.

    Science.gov (United States)

    Tsai, Hsien-Leing; Lee, Shie-Jue

    2004-03-01

    Sperduti and Starita proposed a new type of neural network which consists of generalized recursive neurons for classification of structures. In this paper, we propose an entropy-based approach for constructing such neural networks for classification of acyclic structured patterns. Given a classification problem, the architecture, i.e., the number of hidden layers and the number of neurons in each hidden layer, and all the values of the link weights associated with the corresponding neural network are automatically determined. Experimental results have shown that the networks constructed by our method can have a better performance, with respect to network size, learning speed, or recognition accuracy, than the networks obtained by other methods.

  7. Volume electric dipole origin of second-harmonic generation from metallic membrane with non-centrosymmetry patterns

    CERN Document Server

    Zeng, Yong

    2009-01-01

    In this article, we analytically study second harmonic (SH) generation from thin metallic films with subwavelength, non-centrosymmetry patterns. Because the thickness of the film is much smaller than the SH wavelength, retardation effects are negligible. The far-field SH intensities are thus dominated by an effective electric dipole. These analytical observations are further justified numerically by studying the effect of polarization of the fundamental field on both the SH signal and the electric dipole. It is demonstrated that bulk SH polarization density is comparable with its surface counterpart. The electric dipole, consequently, originates from the entire {volume of the metallic membrane, in contrast to the fact that SH generation from metal surface is generally dominated by a surface dipole.

  8. Direct patterning of vortex generators on a fiber tip using a focused ion beam.

    Science.gov (United States)

    Vayalamkuzhi, Pramitha; Bhattacharya, Shanti; Eigenthaler, Ulrike; Keskinbora, Kahraman; Samlan, C T; Hirscher, Michael; Spatz, Joachim P; Viswanathan, Nirmal K

    2016-05-15

    The realization of spiral phase optical elements on the cleaved end of an optical fiber by focused ion beam milling is presented. A focused Ga+ ion beam with an acceleration voltage of 30 keV is used to etch continuous spiral phase plates and fork gratings directly on the tip of the fiber. The phase characteristics of the output beam generated by the fabricated structures measured via an interference experiment confirmed the presence of phase singularity in the output beam. The devices are expected to be promising candidates for all-fiber beam shaping and optical trapping applications.

  9. Observing and predicting the spatial-temporal pattern of runoff generation processes from the watershed to the regional scale

    Science.gov (United States)

    Weiler, M.

    2012-12-01

    Runoff generation processes are the key to understand and predict watershed dynamics and behaviour under current as well as under changing conditions. A variety of approaches have been developed to observe these processes at the plot scale (e.g. infiltration and sprinkling experiments), the hillslope scale (soil moisture and piezometer networks and trenching) and the watershed scale (hydrograph separation with stable isotopes and natural tracers). However, predicting the four major runoff generation mechanisms (infiltration excess, saturation excess, subsurface flow and deep percolation) without detailed observation in ungauged watershed is still a challenge, but a prerequisite to track water flow pathways and to make adequate prediction for hydrological extremes. Methods have been developed to map dominant runoff generation processes in the field and with digital maps, however, these methods are often static and do not consider the temporal dynamics of runoff generation processes frequently observed with the various experimental approaches. The recently developed parsimonious rainfall-runoff model DROGen can bridge the gap between across spatial scales in ungauged watersheds since parameters are not calibrated. The model incorporates high-resolution GIS data (1m resolution DEM, land-use, impervious surfaces), hydro-geological and pedological data as well as information about the effect of macropores and preferential flow pathways on runoff generation processes with a comprehensive knowledge base from various field observations and experiments. The model was applied to over 6500 meso-scale watershed in the State of Baden-Württemberg in Germany and 15 gauged watersheds were selected for detailed model evaluation. The evaluation was done with field-mapping of runoff generation processes for direct comparison with the simulated pattern of runoff processes for different types of precipitation (high intensity and short duration / low intensity and long duration) and

  10. Patterns of waste generation, treatment and disposal in the chemical and allied industries in Ghana

    Directory of Open Access Journals (Sweden)

    Osei-Wusu Achaw

    2012-09-01

    Full Text Available Environmental pollution and degradation in urban Ghana has been on the increase as a result of the nations drive towards industrialization, a generally weak regulatory regime, and a lack of capacity to manage the environment. This situation is affecting the well-being and livelihood of affected communities. As part of an effort to address the issue, a thirteen (13 item questionnaire was designed and distributed to seventy (70 companies in the chemical and allied industry to solicit and analyze data and information on the their waste management situation. Forty-seven, representing 67.1%, of the distributed questionnaires were completed and returned. The responses were analyzed using tables, percentages and bar charts. The results revealed that while 80.9% of the respondents generate waste as a result of the operation of the plants, 23.3% directly dump their waste into the environment without any prior treatment. Only one company was found that incinerate its waste, and only four (8.5% had comprehensive waste water treatment plants. The low numbers of companies treating the waste they generate prior to disposal means that the chemical and allied industry is contributing to the environmental pollution and degradation in the country.

  11. Evaluation of Ancient and Future Submarine Landslides Along the Central California Coast and Their Potential to Generate Tsunamis

    Science.gov (United States)

    Greene, H. G.; Paull, C. K.; Ward, S.; Ussler, W.; Maher, N. M.

    2001-12-01

    Submarine landslides have been located along the central California continental margin with the use of multibeam bathymetric and sub-bottom profiling data. These features are primarily concentrated on the lower continental slope and in submarine canyons. Recent evaluation of these landslides indicates that they are of various ages and types and formed in different ways. For example, the extensive slope failure morphology on the lower Point Sur slope range from subtle to very sharp geomorphic shapes that suggest these landslides have occurred over a long period of time. These landslides are large features (up to 215 km2) and form primarily from bottom-up processes in a retrogressive fashion. In contrast, some of the landslide scars located on flanks of submarine canyons appear youthful indicating recent activity. Several landslide scars and blocks are also located in the headward parts of Ascension and Monterey canyons. If these scars were generated by catastrophic slope failure, they are of the size (greater than 2 km2) and depth (lie at water depths less than 400 m) to have produced a tsunamis. Based on the presence of possible incipient crown scarps, we have also identified areas within the Ascension-Monterey submarine canyons system where wall failures may occur in the future. We are in the process of using computer simulations to assess the size and extent of tsunamis that these landslides might induce. On the horizon, we hope to develop a full probabilistic hazard estimate for landslide tsunamis run-up around Monterey Bay.

  12. Microparticles generated by decompression stress cause central nervous system injury manifested as neurohypophysial terminal action potential broadening.

    Science.gov (United States)

    Yang, Ming; Kosterin, Paul; Salzberg, Brian M; Milovanova, Tatyana N; Bhopale, Veena M; Thom, Stephen R

    2013-11-01

    The study goal was to use membrane voltage changes during neurohypophysial action potential (AP) propagation as an index of nerve function to evaluate the role that circulating microparticles (MPs) play in causing central nervous system injury in response to decompression stress in a murine model. Mice studied 1 h following decompression from 790 kPa air pressure for 2 h exhibit a 45% broadening of the neurohypophysial AP. Broadening did not occur if mice were injected with the MP lytic agent polyethylene glycol telomere B immediately after decompression, were rendered thrombocytopenic, or were treated with an inhibitor of nitric oxide synthase-2 (iNOS) prior to decompression, or in knockout (KO) mice lacking myeloperoxidase or iNOS. If MPs were harvested from control (no decompression) mice and injected into naive mice, no AP broadening occurred, but AP broadening was observed with injections of equal numbers of MPs from either wild-type or iNOS KO mice subjected to decompression stress. Although not required for AP broadening, MPs from decompressed mice, but not control mice, exhibit NADPH oxidase activation. We conclude that inherent differences in MPs from decompressed mice, rather than elevated MPs numbers, mediate neurological injury and that a component of the perivascular response to MPs involves iNOS. Additional study is needed to determine the mechanism of AP broadening and also mechanisms for MP generation associated with exposure to elevated gas pressure.

  13. The Rh-1 Full-Size Humanoid Robot: Design, Walking Pattern Generation and Control

    Directory of Open Access Journals (Sweden)

    M. Arbulú

    2009-01-01

    Full Text Available This paper is an overview of the humanoid robot Rh-1, the second phase of the Rh project, which was launched by the Robotics Lab at the Carlos III University of Madrid in 2002. The robot mechanical design includes the specifications development in order to construct a platform, which is capable of stable biped walking. At first, the robots’ weights were calculated in order to obtain the inverse dynamics and to select the actuators. After that, mechanical specifications were introduced in order to verify the robot’s structural behaviour with different experimental gaits. In addition, an important aspect is the joints design when their axes are crossed, which is called ‘Joints of Rectangular Axes’ (JRA. The problem with these joints is obtaining two or more degrees of freedom (DOF in small space. The construction of a humanoid robot also includes the design of hardware and software architectures. The main advantage of the proposed hardware and software architectures is the use of standardised solutions frequently used in the automation industry and commercially available hardware components. It provides scalability, modularity and application of standardised interfaces and brings the design of the complex control system of the humanoid robot out of a closed laboratory to industry. Stable walking is the most essential ability for the humanoid robot. The three dimensional Linear Inverted Pendulum Model (3D-LIPM and the Cart-table models had been used in order to achieve natural and dynamic biped walking. Humanoid dynamics is widely simplified by concentrating its mass in the centre of gravity (COG and moving it following the natural inverted pendulum laws (3D-LIPM or by controlling the cart motion (Cart-table model. An offline-calculated motion pattern does not guarantee the walking stability of the humanoid robot. Control architecture for the dynamic humanoid robot walking was developed, which is able to make online modifications of the

  14. Deployable centralizers

    Energy Technology Data Exchange (ETDEWEB)

    Grubelich, Mark C.; Su, Jiann-Cherng; Knudsen, Steven D.

    2017-02-28

    A centralizer assembly is disclosed that allows for the assembly to be deployed in-situ. The centralizer assembly includes flexible members that can be extended into the well bore in situ by the initiation of a gas generating device. The centralizer assembly can support a large load carrying capability compared to a traditional bow spring with little or no installation drag. Additionally, larger displacements can be produced to centralize an extremely deviated casing.

  15. Evolution of Courtship Songs in Xenopus : Vocal Pattern Generation and Sound Production.

    Science.gov (United States)

    Leininger, Elizabeth C; Kelley, Darcy B

    2015-01-01

    The extant species of African clawed frogs (Xenopus and Silurana) provide an opportunity to link the evolution of vocal characters to changes in the responsible cellular and molecular mechanisms. In this review, we integrate several robust lines of research: evolutionary trajectories of Xenopus vocalizations, cellular and circuit-level mechanisms of vocalization in selected Xenopus model species, and Xenopus evolutionary history and speciation mechanisms. Integrating recent findings allows us to generate and test specific hypotheses about the evolution of Xenopus vocal circuits. We propose that reduced vocal sex differences in some Xenopus species result from species-specific losses of sexually differentiated neural and neuromuscular features. Modification of sex-hormone-regulated developmental mechanisms is a strong candidate mechanism for reduced vocal sex differences.

  16. Control Theoretic Modeling and Generated Flow Patterns of a Fish-Tail Robot

    Science.gov (United States)

    Massey, Brian; Morgansen, Kristi; Dabiri, Dana

    2003-11-01

    Many real-world engineering problems involve understanding and manipulating fluid flows. One of the challenges to further progress in the area of active flow control is the lack of appropriate models that are amenable to control-theoretic studies and algorithm design and also incorporate reasonably realistic fluid dynamic effects. We focus here on modeling and model-verification of bio-inspired actuators (fish-fin type structures) used to control fluid dynamic artifacts that will affect speed, agility, and stealth of Underwater Autonomous Vehicles (UAVs). Vehicles using fish-tail type systems are more maneuverable, can turn in much shorter and more constrained spaces, have lower drag, are quieter and potentially more efficient than those using propellers. We will present control-theoretic models for a simple prototype coupled fluid and mechanical actuator where fluid effects are crudely modeled by assuming only lift, drag, and added mass, while neglecting boundary effects. These models will be tested with different control input parameters on an experimental fish-tail robot with the resulting flow captured with DPIV. Relations between the model, the control function choices, the obtained thrust and drag, and the corresponding flow patterns will be presented and discussed.

  17. The Growing Canvas of Biological Development: Multiscale Pattern Generation on an Expanding Lattice of Gene Regulatory Nets

    Science.gov (United States)

    Doursat, René

    The spontaneous generation of an entire organism from a single cell is the epitome of a self-organizing, decentralized complex system. How do nonspatial gene interactions extend in 3-D space? In this work, I present a simple model that simulates some biological developmental principles using an expanding lattice of cells. Each cell contains a gene regulatory network (GRN), modeled as a feedforward hierarchy of switches that can settle in various on/off expression states. Local morphogen gradients provide positional information in input, which is integrated by each GRN to produce differential expression of identity genes in output. Similarly to striping in the Drosophila embryo, the lattice becomes segmented into spatial regions of homogeneous genetic expression that resemble stained-glass motifs. Meanwhile, it also expands by cell proliferation, creating new local gradients of positional information within former single-identity regions. Analogous to a "growing canvas" painting itself, the alternation of growth and patterning results in the creation of a form. This preliminary study attempts to reproduce pattern formation through a multiscale, recursive and modular process. It explores the elusive relationship between nonspatial GRN weights (genotype) and spatial patterns (phenotype). Abstracting from biology in the same spirit as neural networks or swarm optimization, I hope to be contributing to a novel engineering paradigm of system construction that could complement or replace omniscient architects with decentralized collectivities of agents.

  18. A Rich Morphological Diversity of Biosaline Drying Patterns Is Generated by Different Bacterial Species, Different Salts and Concentrations: Astrobiological Implications

    Science.gov (United States)

    Gómez Gómez, José María; Medina, Jesús; Rull, Fernando

    2016-07-01

    Biosaline formations (BSFs) are complex self-organized biomineral patterns formed by "hibernating" bacteria as the biofilm that contains them dries out. They were initially described in drying biofilms of Escherichia coli cells + NaCl. Due to their intricate 3-D morphology and anhydrobiosis, these biomineralogical structures are of great interest in astrobiology. Here we report experimental data obtained with various alkali halide salts (NaF, NaCl, NaBr, LiCl, KCl, CsCl) on BSF formation with E. coli and Bacillus subtilis bacteria at two saline concentrations: 9 and 18 mg/mL. Our results indicate that, except for LiCl, which is inactive, all the salts assayed are active during BSF formation and capable of promoting the generation of distinctive drying patterns at each salt concentration. Remarkably, the BSFs produced by these two bacterial species produce characteristic architectural hallmarks as the BSF dries. The potential biogenicity of these biosaline drying patterns is studied, and the astrobiological implications of these findings are discussed.

  19. Resolution Improvement and Pattern Generator Development for theMaskless Micro-Ion-Beam Reduction Lithography System

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Ximan [Univ. of California, Berkeley, CA (United States)

    2006-05-18

    strategies have been studied. The dependence of the throughput with the exposure field size and the speed of the mechanical stage has been investigated. In order to perform maskless lithography, different micro-fabricated pattern generators have been developed for the MMRL system. Ion beamlet switching has been successfully demonstrated on the MMRL system. A positive bias voltage around 10 volts is sufficient to switch off the ion current on the micro-fabricated pattern generators. Some unexpected problems, such as the high-energy secondary electron radiations, have been discovered during the experimental investigation. Thermal and structural analysis indicates that the aperture displacement error induced by thermal expansion can satisfy the 3δ CD requirement for lithography nodes down to 25 nm. The cross-talking effect near the surface and inside the apertures of the pattern generator has been simulated in a 3-D ray-tracing code. New pattern generator design has been proposed to reduce the cross-talking effect. In order to eliminate the surface charging effect caused by the secondary electrons, a new beam-switching scheme in which the switching electrodes are immersed in the plasma has been demonstrated on a mechanically fabricated pattern generator.

  20. BACTERIAL CAUSES OF LOWER RESPIRATORY TRACT INFECTIONS IN PATIENTS ATTENDING CENTRAL REFERRAL HOSPITAL, GANGTOK WITH REFERENCE TO ANTIBIOTIC RESISTANCE PATTERN

    OpenAIRE

    Priyanka Paul; Tukaram Prabhu

    2013-01-01

    ABSTRACT: BACKGROUND: There is inadequate information from India on various lower respiratory tract pathogens and their resistance pattern in hospital settings. The present study was undertaken to see the bacteriological profile an d the antibiotic resistance pattern of the isolates causing LRTI from this geographic region. OBJECTIVE: To identify and characterize bacterial pathogens causing community acquired and hospital acquired infections with reference to ant...

  1. Flow patterns generated by vibrations in weightlessness in binary mixture with Soret effect.

    Science.gov (United States)

    Shevtsova, Valentina; Melnikov, Denis; Gaponenko, Yuri; Lyubimova, Tatyana; Mialdun, Aliaksandr; Sechenyh, Vitaliy

    2012-07-01

    Vibrational convection refers to the specific flows that appear when a fluid with density gradient is subjected to external vibration. The density gradient may result from the inhomogeneity of temperature or composition. The study of vibrational impact on fluids has fundamental and applied importance. In weightlessness, vibrational convection is an additional way of transporting heat and matter similar to thermo- and solutocapillary convection. The response of the fluid to external forcing depends on the frequency of vibration. The case of small amplitude and high frequency vibration (when the period is much smaller than the characteristic viscous and heat (mass) diffusion times) is of special interest. In this case, the mean flow can be observed in the system, which describes the non-linear response of the fluid to a periodic excitation. The mean flow is most pronounced in the absence of other external forces (in particular, absence of static gravity). The experiment IVIDIL (Influence of Vibration on Diffusion in Liquids) has been conducted on the ISS during more than 3 months in 2009-2010. In the experimental liquids the density changes due to both the temperature and composition. 55 experimental runs of IVIDIL provided rich variety of valuable information about behavior of the liquid in weightlessness which is released with time, [1-3]. The current results provide experimental and numerical evidence of richness of flow patterns and their classification. References: 1. Shevtsova V., Mialdun A., Melnikov D., Ryzhkov I., Gaponenko Y., Saghir Z., Lyubimova T., Legros J.C., IVIDIL experiment onboard ISS: thermodiffusion in presence of controlled vibrations, Comptes Rendus Mecanique, 2011, 339, 310-317 2. Shevtsova V., Lyubimova T., Saghir Z. , Melnikov D., Gaponenko Y. , Sechenyh V. , Legros J.C. , Mialdun A., IVIDIL: on-board g-jitters and diffusion controlled phenomena; Journal of Physics: Conference Series, 2011, 327, 012031 3. Mazzoni S., Shevtsova V., Mialdun A

  2. On the processes generating latitudinal richness gradients: identifying diagnostic patterns and predictions

    Energy Technology Data Exchange (ETDEWEB)

    Hurlbert, Allen H.; Stegen, James C.

    2014-12-02

    Many processes have been put forward to explain the latitudinal gradient in species richness. Here, we use a simulation model to examine four of the most common hypotheses and identify patterns that might be diagnostic of those four hypotheses. The hypotheses examined include (1) tropical niche conservatism, or the idea that the tropics are more diverse because a tropical clade origin has allowed more time for diversification in the tropics and has resulted in few species adapted to extra-tropical climates. (2) The productivity, or energetic constraints, hypothesis suggests that species richness is limited by the amount of biologically available energy in a region. (3) The tropical stability hypothesis argues that major climatic fluctuations and glacial cycles in extratropical regions have led to greater extinction rates and less opportunity for specialization relative to the tropics. (4) Finally, the speciation rates hypothesis suggests that the latitudinal richness gradient arises from a parallel gradient in rates of speciation. We found that tropical niche conservatism can be distinguished from the other three scenarios by phylogenies which are more balanced than expected, no relationship between mean root distance and richness across regions, and a homogeneous rate of speciation across clades and through time. The energy gradient, speciation gradient, and disturbance gradient scenarios all exhibited phylogenies which were more imbalanced than expected, showed a negative relationship between mean root distance and richness, and diversity-dependence of speciation rate estimates through time. Using Bayesian Analysis of Macroevolutionary Mixtures on the simulated phylogenies, we found that the relationship between speciation rates and latitude could distinguish among these three scenarios. We emphasize the importance of considering multiple hypotheses and focusing on diagnostic predictions instead of predictions that are consistent with more than one hypothesis.

  3. Thin film passivation of laser generated 3D micro patterns in lithium manganese oxide cathodes

    Science.gov (United States)

    Pröll, J.; Kohler, R.; Bruns, M.; Oberst, V.; Weidler, P. G.; Heißler, S.; Kübel, C.; Scherer, T.; Prang, R.; Seifert, H. J.; Pfleging, W.

    2013-03-01

    The increasing need for long-life lithium-ion batteries requires the further development of electrode materials. Especially on the cathode side new materials or material composites are needed to increase the cycle lifetime. On the one hand, spinel-type lithium manganese oxide is a promising candidate to be used as cathode material due to its non-toxicity, low cost and good thermal stability. On the other hand, the spinel structure suffers from change in the oxidation state of manganese during cycling which is also accompanied by loss of active material into the liquid electrolyte. The general trend is to enhance the active surface area of the cathode in order to increase lithium-ion mobility through the electrode/electrolyte interface, while an enhanced surface area will also promote chemical degradation. In this work, laser microstructuring of lithium manganese oxide thin films was applied in a first step to increase the active surface area. This was done by using 248 nm excimer laser radiation and chromium/quartz mask imaging techniques. In a second step, high power diode laser-annealing operating at a wavelength of 940 nm was used for forming a cubic spinel-like battery phase. This was verified by means of Raman spectroscopy and cyclic voltammetric measurements. In a last step, the laser patterned thin films were coated with indium tin oxide (ITO) layers with a thickness of 10 nm to 50 nm. The influence of the 3D surface topography as well as the ITO thickness on the electrochemical performance was studied by cyclic voltammetry. Post-mortem studies were carried out by using scanning electron microscopy and focused ion beam analysis.

  4. Investigating Theoretical PV Energy Generation Patterns with Their Relation to the Power Load Curve in Poland

    Directory of Open Access Journals (Sweden)

    Jakub Jurasz

    2016-01-01

    Full Text Available Polish energy sector is (almost from its origin dominated by fossil fuel feed power. This situation results from an abundance of relatively cheap coal (hard and lignite. Brown coal due to its nature is the cheapest energy source in Poland. However, hard coal which fuels 60% of polish power plants is picking up on prices and is susceptible to the coal imported from neighboring countries. Forced by the European Union (EU regulations, Poland is struggling at achieving its goal of reaching 15% of energy consumption from renewable energy sources (RES by 2020. Over the year 2015, RES covered 11.3% of gross energy consumption but this generation was dominated by solid biomass (over 80%. The aim of this paper was to answer the following research questions: What is the relation of irradiation values to the power load on a yearly and daily basis? and how should photovoltaics (PV be integrated in the polish power system? Conducted analysis allowed us to state that there exists a negative correlation between power demand and irradiation values on a yearly basis, but this is likely to change in the future. Secondly, on average, daily values of irradiation tend to follow power load curve over the first hours of the day.

  5. Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients

    OpenAIRE

    Pierre eGuertin

    2014-01-01

    Ambulation or walking is one of the main gaits of locomotion. In terrestrial animals, it may be defined as a series of rhythmic and bilaterally coordinated movement of the limbs which creates a forward movement of the body. This applies regardless of the number of limbs - from arthropods with six or more limbs to bipedal primates. These fundamental similarities among species may explain why comparable neural systems and cellular properties have been found, thus far, to control in similar wa...

  6. Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients

    OpenAIRE

    Guertin, Pierre A.

    2014-01-01

    Ambulation or walking is one of the main gaits of locomotion. In terrestrial animals, it may be defined as a series of rhythmic and bilaterally coordinated movement of the limbs which creates a forward movement of the body. This applies regardless of the number of limbs—from arthropods with six or more limbs to bipedal primates. These fundamental similarities among species may explain why comparable neural systems and cellular properties have been found, thus far, to control in similar ways l...

  7. Mask and wafer evaluation of Sigma7500 pattern generator applied to 65nm logic metal and via layers

    Science.gov (United States)

    Liu, Frank; Shi, Irene; Liu, Qingwei; Zhu, Likeit; Zhao, Shirley; Guo, Eric

    2009-04-01

    As pattern density and OPC complexity grow, photomask write times on electron beam tools increase in proportion. Reducing the write time would decrease mask-making costs, but the performance of any alternative mask writer must meet all of the technical requirements on both mask and wafer. In addition, it is desirable to use existing OPC models in order to avoid the costs of developing and maintaining separate OPC models for each writer. The Sigma7500 deep-UV pattern generator provides the highest resolution available from a laser-based tool, and it has the advantage of maintaining about a 3 hour write time even as the feature count increases. In this study, the Sigma7500 and a variable shaped e-beam (VSB) tool are compared on 65nm metal1 and via1 layers. In the first phase, the Sigma pattern positioning was matched to a SMIC reference grid and a registration value of 10 nm (3s) was achieved with scales removed. In the second phase, M1 and V1 masks were printed with both laser and e-beam writers using the same pattern data and compared on CD uniformity, linearity and proximity. The Sigma7500 met all of the photomask requirements for these layers. The masks were then printed on wafers and the wafer data was evaluated. The results were comparable to those for the e-beam masks and were within the requirements, indicating that the Sigma7500 can handle these layers without the need to revise the e-beam mask OPC models.

  8. Internalization of externalities in the generation costs of electric power centrals of carbon, combined cycle and nuclear; Internalizacion de externalidades en los costos de generacion de centrales electricas de carbon, ciclo combinado y nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Gomez R, M.C. [Universidad Anahuac del Norte (Mexico); Palacios H, J.; Ramirez S, R.; Alonso V, G. [ININ, Carretera Mexico-Toluca Km. 36.5 Ocoyoacac 52750 Edo. de Mexico (Mexico)]. e-mail: fgrivera@avantel.net

    2007-07-01

    The technologies of electric power generation that use fossil fuels, they incorporate in the Even Total Cost of Generation (CTNG) only the direct costs of generation (investment, fuel costs, operation costs and maintenance). nevertheless, the nuclear energy incorporates besides the direct costs, the externalities that causes to the human health and the environment. In this work the CTNG is calculated that incorporates the externalities, of a thermoelectric power station of coal, a plant of combined cycle and of four reactors of Generation III (ABWR, ACR, AP1000 and EPR). The obtained results show that the nuclear power station has smaller CTNG that the technologies that use fossil fuels. It is important to stand out that they are only considering the externalities of the stage of electricity generation, for what the mining phase and transport of the fuel toward the central are not considered in the present document. (Author)

  9. Generations.

    Science.gov (United States)

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  10. Post-fire overland flow generation and inter-rill erosion under simulated rainfall in two eucalypt stands in north-central Portugal.

    Science.gov (United States)

    Malvar, M C; Prats, S A; Nunes, J P; Keizer, J J

    2011-02-01

    The aim of this study was to improve the existing knowledge of the runoff and inter-rill erosion response of forest stands following wildfire, focusing on commercial eucalypt plantations and employing field rainfall simulation experiments (RSE's). Repeated RSE's were carried out in two adjacent but contrasting eucalypt stands on steep hill slopes in north-central Portugal that suffered a moderate severity fire in July 2005. This was done at six occasions ranging from 3 to 24 months after the fire and using a paired-plot experimental design that comprised two pairs of RSE's at each site and occasion. Of the 46 RSE's: (i) 24 and 22 RSE's involved application rates of 45-50 and 80-85 mm h(-1), respectively; (ii) 22 took place in a stand that had been ploughed in down slope direction several years before the wildfire and 24 in an unploughed stand. The results showed a clear tendency for extreme-intensity RSE's to produce higher runoff amounts and greater soil and organic matter losses than the simultaneous high-intensity RSE's on the neighbouring plots. However, there existed marked exceptions, both in space (for one of the plot pairs) and time (under intermediate soil water repellency conditions). Also, overland flow generation and erosion varied significantly between the various field campaigns. This temporal pattern markedly differed from a straightforward decline with time-after-fire and rather suggested a seasonal component, reflecting broad variations in topsoil water repellency. The ploughed site produced less runoff and erosion than the unploughed site, contrary to what would be expected if the down slope ploughing had occurred after the wildfire instead of several years before it. Finally, sediment losses at both study sites were noticeably lower than those reported by other studies involving repeat RSE's, i.e. in Australia and western Spain. This possibly reflected a history of intensive land use in the study region, including in more recent times after the

  11. Determine movement patterns and survival rates of Central Valley Chinook salmon, steelhead and their predators using acoustic tags.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The project’s objective is to document movement patterns and survival rates of Chinook salmon, steelhead, green sturgeon, and other fish from several sources in...

  12. Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

    Directory of Open Access Journals (Sweden)

    Shackleford David M

    2011-06-01

    Full Text Available Abstract Background The clinical use of mefloquine (MQ has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs that do not accumulate in the central nervous system (CNS to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were measured and an early lead chemotype was identified for further optimization. Experimental design The plasma and brain levels of MQ and twenty five, 4-position modified NGQMs were determined using LCMS/MS at 5 min, 1, 6 and 24 h after IV administration (5 mg/kg to male FVB mice. Fraction unbound in brain tissue homogenate was assessed in vitro using equilibrium dialysis and this was then used to calculate brain-unbound concentration from the measured brain total concentration. A five-fold reduction CNS levels relative to mefloquine was considered acceptable. Additional pharmacological properties such as permeability and potency were determined. Results The maximum brain (whole/free concentrations of MQ were 1807/4.9 ng/g. Maximum whole brain concentrations of NGQMs were 23 - 21546 ng/g. Maximum free brain concentrations were 0.5 to 267 ng/g. Seven (28% and two (8% compounds exhibited acceptable whole and free brain concentrations, respectively. Optimization of maximum free brain levels, IC90s (as a measure or potency and residual plasma concentrations at 24 h (as a surrogate for half-life in the same molecule may be feasible since they were not correlated. Diamine quinoline methanols were the most promising lead compounds. Conclusion Reduction of CNS levels of NGQMs relative to mefloquine may be feasible. Optimization of this property together with potency and long half-life may be feasible amongst diamine quinoline methanols.

  13. Spatial pattern and temporal variability of runoff processes in Mediterranean Mountain environments - a case study of the Central Spanish Pyrenees

    NARCIS (Netherlands)

    Butzen, V.; Seeger, K.M.; Casper, M.C.

    2011-01-01

    Mediterranean mountain environments like the Central Spanish Pyrenees show a highly variable rainfall-runoff response, mainly explained by the intense intra- and inter-annual variability of precipitation yield. This leads to a highly differentiated moisture status and therefore it is assumed to lead

  14. Next generation sequencing (NGS) database for tandem repeats with multiple pattern 2°-shaft multicore string matching.

    Science.gov (United States)

    Someswara Rao, Chinta; Raju, S Viswanadha

    2016-03-01

    Next generation sequencing (NGS) technologies have been rapidly applied in biomedical and biological research in recent years. To provide the comprehensive NGS resource for the research, in this paper , we have considered 10 loci/codi/repeats TAGA, TCAT, GAAT, AGAT, AGAA, GATA, TATC, CTTT, TCTG and TCTA. Then we developed the NGS Tandem Repeat Database (TandemRepeatDB) for all the chromosomes of Homo sapiens, Callithrix jacchus, Chlorocebus sabaeus, Gorilla gorilla, Macaca fascicularis, Macaca mulatta, Nomascus leucogenys, Pan troglodytes, Papio anubis and Pongo abelii genome data sets for all those locis. We find the successive occurence frequency for all the above 10 SSR (simple sequence repeats) in the above genome data sets on a chromosome-by-chromosome basis with multiple pattern 2° shaft multicore string matching.

  15. Next generation sequencing (NGS database for tandem repeats with multiple pattern 2°-shaft multicore string matching

    Directory of Open Access Journals (Sweden)

    Chinta Someswara Rao

    2016-03-01

    Full Text Available Next generation sequencing (NGS technologies have been rapidly applied in biomedical and biological research in recent years. To provide the comprehensive NGS resource for the research, in this paper , we have considered 10 loci/codi/repeats TAGA, TCAT, GAAT, AGAT, AGAA, GATA, TATC, CTTT, TCTG and TCTA. Then we developed the NGS Tandem Repeat Database (TandemRepeatDB for all the chromosomes of Homo sapiens, Callithrix jacchus, Chlorocebus sabaeus, Gorilla gorilla, Macaca fascicularis, Macaca mulatta, Nomascus leucogenys, Pan troglodytes, Papio anubis and Pongo abelii genome data sets for all those locis. We find the successive occurence frequency for all the above 10 SSR (simple sequence repeats in the above genome data sets on a chromosome-by-chromosome basis with multiple pattern 2° shaft multicore string matching.

  16. Next generation sequencing (NGS) database for tandem repeats with multiple pattern 2°-shaft multicore string matching

    Science.gov (United States)

    Someswara Rao, Chinta; Raju, S. Viswanadha

    2016-01-01

    Next generation sequencing (NGS) technologies have been rapidly applied in biomedical and biological research in recent years. To provide the comprehensive NGS resource for the research, in this paper , we have considered 10 loci/codi/repeats TAGA, TCAT, GAAT, AGAT, AGAA, GATA, TATC, CTTT, TCTG and TCTA. Then we developed the NGS Tandem Repeat Database (TandemRepeatDB) for all the chromosomes of Homo sapiens, Callithrix jacchus, Chlorocebus sabaeus, Gorilla gorilla, Macaca fascicularis, Macaca mulatta, Nomascus leucogenys, Pan troglodytes, Papio anubis and Pongo abelii genome data sets for all those locis. We find the successive occurence frequency for all the above 10 SSR (simple sequence repeats) in the above genome data sets on a chromosome-by-chromosome basis with multiple pattern 2° shaft multicore string matching. PMID:26981434

  17. NON-NEUTRALIZED ELECTRIC CURRENT PATTERNS IN SOLAR ACTIVE REGIONS: ORIGIN OF THE SHEAR-GENERATING LORENTZ FORCE

    Energy Technology Data Exchange (ETDEWEB)

    Georgoulis, Manolis K. [Research Center for Astronomy and Applied Mathematics of the Academy of Athens, 4 Soranou Efesiou Street, Athens GR-11527 (Greece); Titov, Viacheslav S.; Mikic, Zoran [Predictive Science, Inc., 9990 Mesa Rim Road, San Diego, CA 92121 (United States)

    2012-12-10

    Using solar vector magnetograms of the highest available spatial resolution and signal-to-noise ratio, we perform a detailed study of electric current patterns in two solar active regions (ARs): a flaring/eruptive and a flare-quiet one. We aim to determine whether ARs inject non-neutralized (net) electric currents in the solar atmosphere, responding to a debate initiated nearly two decades ago that remains inconclusive. We find that well-formed, intense magnetic polarity inversion lines (PILs) within ARs are the only photospheric magnetic structures that support significant net current. More intense PILs seem to imply stronger non-neutralized current patterns per polarity. This finding revises previous works that claim frequent injections of intense non-neutralized currents by most ARs appearing in the solar disk but also works that altogether rule out injection of non-neutralized currents. In agreement with previous studies, we also find that magnetically isolated ARs remain globally current-balanced. In addition, we confirm and quantify the preference of a given magnetic polarity to follow a given sense of electric currents, indicating a dominant sense of twist in ARs. This coherence effect is more pronounced in more compact ARs with stronger PILs and must be of sub-photospheric origin. Our results yield a natural explanation of the Lorentz force, invariably generating velocity and magnetic shear along strong PILs, thus setting a physical context for the observed pre-eruption evolution in solar ARs.

  18. Self-organization in patch pattern dynamics along the climatic gradient of the Judean lowland in central Israel

    Energy Technology Data Exchange (ETDEWEB)

    Shoshany, M.

    2009-07-01

    The role of Self-organization in the formation, evolution and recovery of natural systems from organismic to global scale cannot be over-estimated. Many of these systems represent a type of patch pattern dynamic behavior where patches are created, spread, expanded, aggregated, dissected and dissolved in parallel, forming myriad patterns through their evolution. Self-organization concern the functioning of intrinsic mechanisms which intrinsically regulate pattern changes leading these systems toward order following phases of disturbance or structural transformation (e.g., from herbaceous ecosystem to shrub lands). The aim of this paper is to present a new approach of Converging Self-Organization (CSO) coupling between information from geo simulated self-organization and remote sensing data. (Author) 4 refs.

  19. Norepinephrine release from Locus Ceruleus:a central regulator for the CNS spatio-temporal activation pattern?

    Directory of Open Access Journals (Sweden)

    Marco Atzori

    2016-08-01

    Full Text Available Norepinephrine (NE is synthesized in the Locus Coeruleus (LC of the brainstem, from where it is released by axonal varicosities throughout the brain via volume transmission. A wealth of data from clinics and from animal models indicates that this catecholamine coordinates the activity of the central nervous system and of the whole organism by modulating cell function in a vast number of brain areas in a coordinated manner. The ubiquity of NE receptors, the daunting number of cerebral areas regulated by the catecholamine, as well as the variety of cellular effects and of their timescales have contributed so far to defeat the attempts to integrate central adrenergic function into a unitary and coherent framework.Since three main families of NE receptors are represented – in decreasing order of affinity for the catecholamine – by: 2 adrenoceptors (2Rs, high affinity, 1 adrenoceptors (1Rs, intermediate affinity, and  adrenoceptors (Rs, low affinity, on a pharmacological basis, and on the ground of recent studies on cellular and systemic central noradrenergic effects, we propose that an increase in LC tonic activity promotes the emergence of four global states covering the whole spectrum of brain activation: 1 sleep: virtual absence of NE, 2 quiet wake: activation of 2Rs, 3 active wake/physiological stress: activation of 2- and 1Rs, 4 distress: activation of 2-, 1-, and Rs.We postulate that excess intensity and/or duration of states 3 and 4 may lead to maladaptive plasticity, causing – in turn – a variety of neuropsychiatric illnesses including depression, schizophrenic psychoses, anxiety disorders, and attention deficit. The interplay between tonic and phasic LC activity identified in the LC in relationship with behavioral response is of critical importance in defining the short- and long-term biological mechanisms associated with the basic states postulated for the central nervous system. While the model

  20. Investigation of Vortex Clouds and Droplet Sizes in Heated Water Spray Patterns Generated by Axisymmetric Full Cone Nozzles

    Science.gov (United States)

    Naz, M. Y.; Sulaiman, S. A.; Ariwahjoedi, B.; Ku Shaari, Ku Zilati

    2013-01-01

    The hot water sprays are an important part of many industrial processes, where the detailed knowledge of physical phenomena involved in jet transportation, interaction, secondary breakup, evaporation, and coalescence of droplets is important to reach more efficient processes. The objective of the work was to study the water spray jet breakup dynamics, vortex cloud formation, and droplet size distribution under varying temperature and load pressure. Using a high speed camera, the spray patterns generated by axisymmetric full cone nozzles were visualized as a function water temperature and load pressure. The image analysis confirmed that the spray cone angle and width do not vary significantly with increasing Reynolds and Weber numbers at early injection phases leading to increased macroscopic spray propagation. The formation and decay of semitorus like vortex clouds were also noticed in spray structures generated at near water boiling point temperature. For the nozzle with smallest orifice diameter (1.19 mm), these vortex clouds were very clear at 90°C heating temperature and 1 bar water load pressure. In addition, the sauter mean diameter (SMD) of the spray droplets was also measured by using Phase Doppler Anemometry (PDA) at different locations downstream of the nozzle exit. It was noticed that SMD varies slightly w.r.t. position when measured at room temperature whereas at higher temperature values, it became almost constant at distance of 55 mm downstream of the nozzle exit. PMID:24307881

  1. Investigation of vortex clouds and droplet sizes in heated water spray patterns generated by axisymmetric full cone nozzles.

    Science.gov (United States)

    Naz, M Y; Sulaiman, S A; Ariwahjoedi, B; Ku Shaari, Ku Zilati

    2013-01-01

    The hot water sprays are an important part of many industrial processes, where the detailed knowledge of physical phenomena involved in jet transportation, interaction, secondary breakup, evaporation, and coalescence of droplets is important to reach more efficient processes. The objective of the work was to study the water spray jet breakup dynamics, vortex cloud formation, and droplet size distribution under varying temperature and load pressure. Using a high speed camera, the spray patterns generated by axisymmetric full cone nozzles were visualized as a function water temperature and load pressure. The image analysis confirmed that the spray cone angle and width do not vary significantly with increasing Reynolds and Weber numbers at early injection phases leading to increased macroscopic spray propagation. The formation and decay of semitorus like vortex clouds were also noticed in spray structures generated at near water boiling point temperature. For the nozzle with smallest orifice diameter (1.19 mm), these vortex clouds were very clear at 90°C heating temperature and 1 bar water load pressure. In addition, the sauter mean diameter (SMD) of the spray droplets was also measured by using Phase Doppler Anemometry (PDA) at different locations downstream of the nozzle exit. It was noticed that SMD varies slightly w.r.t. position when measured at room temperature whereas at higher temperature values, it became almost constant at distance of 55 mm downstream of the nozzle exit.

  2. Investigation of Vortex Clouds and Droplet Sizes in Heated Water Spray Patterns Generated by Axisymmetric Full Cone Nozzles

    Directory of Open Access Journals (Sweden)

    M. Y. Naz

    2013-01-01

    Full Text Available The hot water sprays are an important part of many industrial processes, where the detailed knowledge of physical phenomena involved in jet transportation, interaction, secondary breakup, evaporation, and coalescence of droplets is important to reach more efficient processes. The objective of the work was to study the water spray jet breakup dynamics, vortex cloud formation, and droplet size distribution under varying temperature and load pressure. Using a high speed camera, the spray patterns generated by axisymmetric full cone nozzles were visualized as a function water temperature and load pressure. The image analysis confirmed that the spray cone angle and width do not vary significantly with increasing Reynolds and Weber numbers at early injection phases leading to increased macroscopic spray propagation. The formation and decay of semitorus like vortex clouds were also noticed in spray structures generated at near water boiling point temperature. For the nozzle with smallest orifice diameter (1.19 mm, these vortex clouds were very clear at 90°C heating temperature and 1 bar water load pressure. In addition, the sauter mean diameter (SMD of the spray droplets was also measured by using Phase Doppler Anemometry (PDA at different locations downstream of the nozzle exit. It was noticed that SMD varies slightly w.r.t. position when measured at room temperature whereas at higher temperature values, it became almost constant at distance of 55 mm downstream of the nozzle exit.

  3. Central ventilators and VRF technology. The pulse generator for efficiency from tomorrow?; Zentrallueftungsgeraete und VRF-Technik. Die Effizienz-Taktgeber von morgen?

    Energy Technology Data Exchange (ETDEWEB)

    Schellhorn, Martin

    2011-07-01

    Previously it was simpler: the specialised craftsman had the choice between gas and oil at a new heating system. In case of ventilation systems the TGA specialized planners generally opted for a central controller which handles the necessary air conditioning by means of chillers and reheaters. Fan coils in the rooms provide an individual fine adjustment of the desired climate. Today, the efficiency in combination with high comfort is turned to a pulse generator. Almost unnoticed, a plant combination prevails which should be examined carefully - the connection between central HVAC equipment and VRF equipment.

  4. Cell-Autonomous Repression of Shh by Transcription Factor Pax6 Regulates Diencephalic Patterning by Controlling the Central Diencephalic Organizer

    Directory of Open Access Journals (Sweden)

    Isabel Martín Caballero

    2014-09-01

    Full Text Available During development, region-specific patterns of regulatory gene expression are controlled by signaling centers that release morphogens providing positional information to surrounding cells. Regulation of signaling centers themselves is therefore critical. The size and the influence of a Shh-producing forebrain organizer, the zona limitans intrathalamica (ZLI, are limited by Pax6. By studying mouse chimeras, we find that Pax6 acts cell autonomously to block Shh expression in cells around the ZLI. Immunoprecipitation and luciferase assays indicate that Pax6 can bind the Shh promoter and repress its function. An analysis of chimeras suggests that many of the regional gene expression pattern defects that occur in Pax6−/− diencephalic cells result from a non-cell-autonomous position-dependent defect of local intercellular signaling. Blocking Shh signaling in Pax6−/− mutants reverses major diencephalic patterning defects. We conclude that Pax6’s cell-autonomous repression of Shh expression around the ZLI is critical for many aspects of normal diencephalic patterning.

  5. Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer.

    Science.gov (United States)

    Caballero, Isabel Martín; Manuel, Martine N; Molinek, Michael; Quintana-Urzainqui, Idoia; Mi, Da; Shimogori, Tomomi; Price, David J

    2014-09-11

    During development, region-specific patterns of regulatory gene expression are controlled by signaling centers that release morphogens providing positional information to surrounding cells. Regulation of signaling centers themselves is therefore critical. The size and the influence of a Shh-producing forebrain organizer, the zona limitans intrathalamica (ZLI), are limited by Pax6. By studying mouse chimeras, we find that Pax6 acts cell autonomously to block Shh expression in cells around the ZLI. Immunoprecipitation and luciferase assays indicate that Pax6 can bind the Shh promoter and repress its function. An analysis of chimeras suggests that many of the regional gene expression pattern defects that occur in Pax6(-/-) diencephalic cells result from a non-cell-autonomous position-dependent defect of local intercellular signaling. Blocking Shh signaling in Pax6(-/-) mutants reverses major diencephalic patterning defects. We conclude that Pax6's cell-autonomous repression of Shh expression around the ZLI is critical for many aspects of normal diencephalic patterning.

  6. The invasive ctenophore Mnemiopsis leidyi in the central Baltic Sea: seasonal phenology and hydrographic influence on spatio-temporal distribution patterns

    DEFF Research Database (Denmark)

    Schaber, M.; Haslob, H.; Huwer, Bastian;

    2011-01-01

    the invasion and related to ambient hydrographic parameters. Results show a clear seasonal pattern. In contrast to the majority of other native and exotic habitats, the seasonal phenology showed highest abundances in spring and autumn months and only sporadic or even no appearance during summer. Vertical...... distribution was mostly confined to water layers below the permanent halocline and significantly influenced by ambient temperature. Our results indicate that there is no self-sustaining population of M. leidyi in the central Baltic Sea. Instead, the species is most likely re-introduced into the Bornholm Basin...

  7. Incubation patterns in a central-place forager affect lifetime reproductive success: scaling of patterns from a foraging bout to a lifetime.

    Directory of Open Access Journals (Sweden)

    Akiko Shoji

    Full Text Available BACKGROUND: Long-lived seabirds face a conflict between current and lifelong reproductive success. During incubation shifts, egg neglect is sometimes necessary to avoid starvation, but may compromise the current reproductive attempt. However, factors underlying this decision process are poorly understood. We focus on the ancient murrelet, Synthliboramphus antiquus, an alcid with exceptionally long incubation shift lengths, and test the impact of environmental factors on incubation shift length in relation to reproductive success. METHODOLOGY/PRINCIPAL FINDINGS: Using an information theoretic approach, we show that incubation shift length was a strong predictor of reproductive success for ancient murrelets at Reef Island, Haida Gwaii, British Columbia, Canada during the 2007 and 2008 breeding seasons. The most important factors explaining an individual's shift length were egg size, wind speed and the length of the mate's previous shift. Wind speed and tide height were the two most important factors for determining foraging behavior, as measured by dive frequency and depth. CONCLUSIONS/SIGNIFICANCE: Our study demonstrates that (i species-specific reproductive strategies interact with environmental conditions such as wind speed to form multiple incubation patterns and (ii maintaining regular incubation shifts is an essential component of reproductive success.

  8. The use of decision tree induction and artificial neural networks for recognizing the geochemical distribution patterns of LREE in the Choghart deposit, Central Iran

    Science.gov (United States)

    Zaremotlagh, S.; Hezarkhani, A.

    2017-04-01

    Some evidences of rare earth elements (REE) concentrations are found in iron oxide-apatite (IOA) deposits which are located in Central Iranian microcontinent. There are many unsolved problems about the origin and metallogenesis of IOA deposits in this district. Although it is considered that felsic magmatism and mineralization were simultaneous in the district, interaction of multi-stage hydrothermal-magmatic processes within the Early Cambrian volcano-sedimentary sequence probably caused some epigenetic mineralizations. Secondary geological processes (e.g., multi-stage mineralization, alteration, and weathering) have affected on variations of major elements and possible redistribution of REE in IOA deposits. Hence, the geochemical behaviors and distribution patterns of REE are expected to be complicated in different zones of these deposits. The aim of this paper is recognizing LREE distribution patterns based on whole-rock chemical compositions and automatic discovery of their geochemical rules. For this purpose, the pattern recognition techniques including decision tree and neural network were applied on a high-dimensional geochemical dataset from Choghart IOA deposit. Because some data features were irrelevant or redundant in recognizing the distribution patterns of each LREE, a greedy attribute subset selection technique was employed to select the best subset of predictors used in classification tasks. The decision trees (CART algorithm) were pruned optimally to more accurately categorize independent test data than unpruned ones. The most effective classification rules were extracted from the pruned tree to describe the meaningful relationships between the predictors and different concentrations of LREE. A feed-forward artificial neural network was also applied to reliably predict the influence of various rock compositions on the spatial distribution patterns of LREE with a better performance than the decision tree induction. The findings of this study could be

  9. Environmental controls on spatial patterns in the long-term persistence of giant kelp in central California

    Science.gov (United States)

    Young, Mary Alida; Cavanaugh, Kyle C.; Bell, Tom W.; Raimondi, Peter T.; Edwards, Christopher A.; Drake, Patrick T.; Erikson, Li H.; Storlazzi, Curt

    2016-01-01

    As marine management is moving towards the practice of protecting static areas, it is 44 important to make sure protected areas capture and protect persistent populations. Rocky reefs in 45 many temperate areas worldwide serve as habitat for canopy forming macroalgae and these 46 structure forming species of kelps (order Laminariales) often serve as important habitat for a great 47 diversity of species. Macrocystis pyrifera is the most common canopy forming kelp species found 48 along the coast of California but the distribution and abundance of M. pyrifera varies in space and 49 time. The purpose of this study is to determine what environmental parameters are correlated with 50 the spatial and temporal persistence of M. pyrifera along the central coast of California and how 51 well those environmental parameters can be used to predict areas where M. pyrifera is more likely 52 to persist. Nine environmental variables considered in this study included depth of the seafloor, 53 structure of the rocky reef, proportion of rocky reef, size of kelp patch, biomass of kelp within a 54 patch, distance from the edge of a kelp patch, sea surface temperature, wave orbital velocities, and 55 population connectivity of individual kelp patches. Using a generalized linear mixed effects model 56 (GLMM), the persistence of M. pyrifera was significantly associated with seven of the nine 57 variables considered: depth, complexity of the rocky reef, proportion of rock, patch biomass, 58 distance from the edge of a patch, population connectivity, and wave-orbital velocities. These 59 seven environmental variables were then used to predict the persistence of kelp across the central 60 coast and these predictions were compared to a reserved dataset of M. pyrifera persistence, which 61 was not used in the creation of the GLMM. The environmental variables were shown to accurately 62 predict the persistence of M. pyrifera within the central coast of California (r = 0.71, Pmanagement of these

  10. The ArF laser for the next-generation multiple-patterning immersion lithography supporting green operations

    Science.gov (United States)

    Ishida, Keisuke; Ohta, Takeshi; Miyamoto, Hirotaka; Kumazaki, Takahito; Tsushima, Hiroaki; Kurosu, Akihiko; Matsunaga, Takashi; Mizoguchi, Hakaru

    2016-03-01

    Multiple patterning ArF immersion lithography has been expected as the promising technology to satisfy tighter leading edge device requirements. One of the most important features of the next generation lasers will be the ability to support green operations while further improving cost of ownership and performance. Especially, the dependence on rare gases, such as Neon and Helium, is becoming a critical issue for high volume manufacturing process. The new ArF excimer laser, GT64A has been developed to cope with the reduction of operational costs, the prevention against rare resource shortage and the improvement of device yield in multiple-patterning lithography. GT64A has advantages in efficiency and stability based on the field-proven injection-lock twin-chamber platform (GigaTwin platform). By the combination of GigaTwin platform and the advanced gas control algorithm, the consumption of rare gases such as Neon is reduced to a half. And newly designed Line Narrowing Module can realize completely Helium free operation. For the device yield improvement, spectral bandwidth stability is important to increase image contrast and contribute to the further reduction of CD variation. The new spectral bandwidth control algorithm and high response actuator has been developed to compensate the offset due to thermal change during the interval such as the period of wafer exchange operation. And REDeeM Cloud™, new monitoring system for managing light source performance and operations, is on-board and provides detailed light source information such as wavelength, energy, E95, etc.

  11. Comparison of Growth and Development Patterns of Fenneropenaeus chinensis (Osbeck) Huanghai No.1and the First Generation of Wild Population

    Institute of Scientific and Technical Information of China (English)

    Yuying HE; Ping LIU; Qingyin WANG; Jian LI; Zhaoxia LI

    2013-01-01

    [Objective] The aim was to estimate the developmental characteristics of Huanghai No.1 and the first generation of wild population in Fenneropenaeus chinensis for providing a reference for the development,feeding management and breeding.[Method] Four growth models were used to fit the growth patterns of 15 morphological traits.The squared multiple correlation coefficient (R2) of the Cubic growth model was higher than the other three models,so it was selected to investigate the growth pattern and age in month at inflexion.[Result] Ages in month at inflexion of body weight in Huanghai No.1 and the G1 population were 2.87 (body weight at inflexion was 14.98 g) and 4.05 (body weight at inflexion was 26.26 g),respectively.In addition,Ages in month at inflexion of morphological characters in Huanghai No.1 were from 0.51 to 3.07.CL had the most rapid growth rate,followed by AW,CH,AH,CW,BL,FL,AL5,AL3,AL4,TL,AL2,AL1,and AL6.Ages in month at inflexion in the G1 population were from 2.38 to 3.08,except that of AL2,and the order of achieving the most rapid growth rate was AL2,AL1,AL3,AL4,CH,AL5,CW,FL,AH,AW,TL,CL,BL,and AL6,that delayed one month than that of Huanghai No.1 except AL2 and AL1.[Conclusion] The development of Huanghai No.1 cultivar was advanced for about one month compared to that of the G1 population.

  12. Automated pattern recognition to support geological mapping and exploration target generation - A case study from southern Namibia

    Science.gov (United States)

    Eberle, Detlef; Hutchins, David; Das, Sonali; Majumdar, Anandamayee; Paasche, Hendrik

    2015-06-01

    to the result obtained from unsupervised fuzzy clustering. Furthermore, a comparison of the aposterior probability of class assignment with the trustworthiness values provided by fuzzy clustering also indicates only slight differences. These observed differences can be explained by the exponential class probability term which tends to deliver either fairly high or low probability values. The methodology and results presented here demonstrate that automated objective pattern recognition can essentially contribute to geological mapping of large study areas and mineral exploration target generation. This methodology is considered well suited to a number of African countries whose large territories have recently been covered by high resolution airborne geophysical data, but where existing geological mapping is poor, incomplete or outdated.

  13. Temporal patterns of abundance of Aedes aegypti and Aedes albopictus (Diptera: Culicidae and mitochondrial DNA analysis of Ae. albopictus in the Central African Republic.

    Directory of Open Access Journals (Sweden)

    Basile Kamgang

    Full Text Available The invasive Asian tiger mosquito Aedes albopictus (Diptera: Culicidae was first reported in central Africa in 2000, in Cameroon, with the indigenous mosquito species Ae. aegypti (Diptera: Culicidae. Today, this invasive species is present in almost all countries of the region, including the Central African Republic (CAR, where it was first recorded in 2009. As invasive species of mosquitoes can affect the distribution of native species, resulting in new patterns of vectors and concomitant risk for disease, we undertook a comparative study early and late in the wet season in the capital and the main cities of CAR to document infestation and the ecological preferences of the two species. In addition, we determined the probable geographical origin of invasive populations of Ae. albopictus with two mitochondrial DNA genes, COI and ND5. Analysis revealed that Ae. aegypti was more abundant earlier in the wet season and Ae. albopictus in the late wet season. Used tyres were the most heavily colonized productive larval habitats for both species in both seasons. The invasive species Ae. albopictus predominated over the resident species at all sites in which the two species were sympatric. Mitochondrial DNA analysis revealed broad low genetic diversity, confirming recent introduction of Ae. albopictus in CAR. Phylogeographical analysis based on COI polymorphism indicated that the Ae. albopictus haplotype in the CAR population segregated into two lineages, suggesting multiple sources of Ae. albopictus. These data may have important implications for vector control strategies in central Africa.

  14. Long-range atmospheric transport of PAHs, PCBs and PBDEs to the central and eastern Mediterranean and changes of PCB and PBDE congener patterns in summer 2010

    Science.gov (United States)

    Mulder, Marie D.; Heil, Angelika; Kukučka, Petr; Kuta, Jan; Přibylová, Petra; Prokeš, Roman; Lammel, Gerhard

    2015-06-01

    The central and eastern Mediterranean is a receptor area for persistent organic pollutants (POPs) emitted in western, central and eastern Europe, particularly during summer. Atmospheric concentrations of PCBs, DDXs, PBDEs, penta- and hexachlorobenzene were measured during a ship-borne survey in the summer of 2010. The concentration of PCBs (sum of 7 congeners) was 3.61 (2.08-7.72) pg m-3, of which 6.7% was associated with the particulate phase. The mean concentration of DDT isomers and their metabolites, DDE and DDD, was 2.60 (0.46-7.60) pg m-3 (particulate mass fraction θ = 0.097), of penta- and hexachlorobenzene 0.22 (PBDEs (sum of 8 congeners) 7.31 (2.80-19.89) pg m-3. The air masses studied had been transported mostly across central Europe, some crossing western Europe. The observed changes of PCB congener patterns along transport routes are in agreement with the perception that the reaction with the OH radical is dominating PCB atmospheric lifetime, and indicate an overestimation of the second order gas-phase reaction rate coefficient of PCB153 with OH by structure-activity relationship.

  15. BACTERIAL CAUSES OF LOWER RESPIRATORY TRACT INFECTIONS IN PATIENTS ATTENDING CENTRAL REFERRAL HOSPITAL, GANGTOK WITH REFERENCE TO ANTIBIOTIC RESISTANCE PATTERN

    Directory of Open Access Journals (Sweden)

    Priyanka Paul

    2013-10-01

    Full Text Available ABSTRACT: BACKGROUND: There is inadequate information from India on various lower respiratory tract pathogens and their resistance pattern in hospital settings. The present study was undertaken to see the bacteriological profile an d the antibiotic resistance pattern of the isolates causing LRTI from this geographic region. OBJECTIVE: To identify and characterize bacterial pathogens causing community acquired and hospital acquired infections with reference to antibiogram pattern. MET HODS: A total of 137 samples from patients suffering from lower respiratory tract infections were studied. All the sputum samples were subjected to gram staining, culture. Various organisms were identified by standard methods. The Kirby – Bauer method was e mployed to perform the antibiotic sensitivity on Mueller Hinton agar [MHA]. For Streptococcus pneumoniae blood agar was used. MHA with 4% NaCl was used to detect methicillin resistant Staphylococcus aureus [MRSA]. RESULTS: Growth of pathogens was obtained in 66.4% of sputum samples in case of inpatients and in 33.5% outpatients. Klebsiella pneumonia [15.3%] was the predominant isolate among the inpatients whereas Streptococcus pneumonia [8.5%] was the most common pathogen isolated from outpatients. Haemophi lus influenzae was not isolated. Quinolone was found to be most effective antibiotic against gram negative organi sms. A single isolate of Morax ella catarrhalis was isolated from a case of MDR - TB. CONCLUSION : Culture and susceptibility reports should be enc ouraged before therapy to combat the problem of emergence of MDR, ESBL and MRSA strains and to subside the economic burden due to increase in cost according to the consequence of development of antibiotic resistant microbial strains

  16. Changes in Central European Soil Moisture Availability and Atmospheric Circulation Patterns between 1875 and 2005 - Regional Climate Change in Progress?

    Science.gov (United States)

    Trnka, M.; Kysely, J.; Dubrovsky, M.; Mozny, M.; Hostynek, J.; Svoboda, M.; Hayes, M. J.; Zalud, Z.

    2007-12-01

    Relationships between the soil moisture availability and the atmospheric circulation in Central Europe were analyzed for the period 1881-2005. The analysis was based on the Hess-Brezowsky catalogue of circulation types (CTs), and a series of weekly self-calibrated Palmer Z-index (scZ-index) and Palmer Drought Severity Index (scPDSI) values at seven stations where high-quality daily data has recently become available. The results show that the large-scale droughts during spring months (MAM) were associated with east (E), south (S), and south- east (SE) circulation types, whereas during summer (JJA) and the whole vegetation season, i.e., April-September (VEG), the Central Europe high pressure systems (HM) and east (E) circulation types were conducive to drought. Statistically significant drying trends were noted at a majority of the stations, especially during MAM and JJA, over the whole period for which the scPDSI and scZ-index series were available (1875-2005). Although almost no statistically significant tendencies were found prior to 1940, a significant tendency towards more intense drought was present at all sites after this year. The largest drying trend was noted during the VEG and AMJ seasons. The overall drying trend might be associated with shifts in the frequency of CTs, especially during AMJ. Although the aggregate frequency of occurrence of drought-conducive CTs (i.e. E, S and HM) remained stable at approximately 30% up to the 1940s, a steady increase to the present 55% frequency is observed afterwards. Higher frequencies of S and HM types drove the observed increase of drought-conducive CTs at the expense of N types that are associated with wet conditions. The long-term shifts in the frequency of circulation types conducive to drought explain more than 50% of the long-term variations of both scZ-index and PDSI values over the territory of the Czech Republic, and they are likely to affect whole central European region as well. Acknowledgement: This study

  17. Pareto optimality between width of central lobe and peak sidelobe intensity in the far-field pattern of lossless phase-only filters for enhancement of transverse resolution.

    Science.gov (United States)

    Mukhopadhyay, Somparna; Hazra, Lakshminarayan

    2015-11-01

    Resolution capability of an optical imaging system can be enhanced by reducing the width of the central lobe of the point spread function. Attempts to achieve the same by pupil plane filtering give rise to a concomitant increase in sidelobe intensity. The mutual exclusivity between these two objectives may be considered as a multiobjective optimization problem that does not have a unique solution; rather, a class of trade-off solutions called Pareto optimal solutions may be generated. Pareto fronts in the synthesis of lossless phase-only pupil plane filters to achieve superresolution with prespecified lower limits for the Strehl ratio are explored by using the particle swarm optimization technique.

  18. Large-scale patterns of Quercus ilex, Quercus suber, and Quercus pyrenaica regeneration in central-western Spain

    DEFF Research Database (Denmark)

    Plieninger, Tobias; Rolo, Víctor; Moreno, Gerardo

    2010-01-01

    categories, from small seedlings to large saplings, and for the three oak species studied, especially the evergreens. Of the Quercus ilex, Q. suber, and Q. pyrenaica plots studied, 49%, 62%, and 20% were lacking any small seedlings, and 82%, 96%, and 56% did not have any large saplings, respectively......In Central-Western Spain, forests and woodlands composed of Quercus sp. support outstanding levels of biodiversity, but there is increasing concern about their long-term persistence due to a lack of regeneration. We hypothesize that this regenerative lack is operating on a large geographic scale...... and Q. suber were positively correlated with all understory variables, suggesting that the presence of pioneer shrubs represent a major safe site for early tree recruitment, independent from specific shrub species. © 2010 Springer Science+Business Media, LLC....

  19. Efficacy of ovitrap colors and patterns for attracting Aedes albopictus at suburban field sites in north-central Florida.

    Science.gov (United States)

    Hoel, David F; Obenauer, Peter J; Clark, Marah; Smith, Richard; Hughes, Tony H; Larson, Ryan T; Diclaros, Joseph W; Allan, Sandra A

    2011-09-01

    We sought to visually enhance the attractiveness of a standard black ovitrap routinely used in surveillance of the Asian tiger mosquito, Aedes albopictus, and now being used as lethal ovitraps in Ae. aegypti dengue control programs. Black plastic drinking cups (ovitraps) were visually altered to offer field populations of gravid female Ae. albopictus 6 different oviposition site choices. Trials were conducted at 3 field locations in Gainesville, Orange Park, and Jacksonville, FL, during July-August 2009. A black glossy cup served as the control and was tested against 5 cup choices consisting of white, blue, orange, or black-and-white contrasting patterns (checkered or vertically striped). Means (SE) of eggs collected over 6 wk for each choice were: black 122.53 (9.63) > blue 116.74 (10.74) > checkered 101.84 (9.53) > orange 97.15 (7.95) > striped 84.62 (8.17) > white 81.84 (8.74). Black ovitraps outperformed competing colored and contrasting patterned ovicups with respect to choice from gravid Ae. albopictus seeking artificial oviposition sites.

  20. Increasing occurrence of high-intensity rainstorm events relevant for the generation of soil erosion in a temperate lowland region in Central Europe

    Science.gov (United States)

    Mueller, Eva Nora; Pfister, Angela

    2011-12-01

    SummaryRainfall times series with a high temporal resolution of 1 min for the Emscher-Lippe catchment area were analysed for trends in regard to erosion-relevant storm events with intensities larger than 0.3 mm/min (>20 mm/h) for the last 70 years using the Mann-Kendall test. The analysis data showed for all investigated stations an increase of rainstorm events with erosion-relevant rainfall intensities; the trend was more pronounced over the last 35 years and was shown to be statistical significant for a critical zone with rainfall characteristics of: intensity i Rain = 0.3-0.7 mm/min, duration t Rain = 2-10 min and depth h Rain = 1-3 mm. The increase of rainstorm events over the last 35 years was more pronounced in the summer season (July-September), but increases were detected also in the other seasons. The high-intensity storm events occured only ca. 4-15 times/year; the estimated trend increases of up to 0.5 events/year could therefore result in a multiplication of the occurrence of these storm events within only a few decades. This study has shown for the first time that the rainfall regime for temperate lowland regions in Germany has changed within its erosion-relevant spectrum over the last couple of decades. Parallel to the changes in the rainfall regime, increases in the annual and seasonal average temperature and changes in the occurrence of circulation patterns responsible for the generation of high-intensity storms were found, however not in the occurrence of thunderstorms. A climate-change driven increase of rain storm events over the last couple of decades and a potential future continuation of this trend may have several adverse effects for the study area and potentially for a larger region in Central Europe, for example an increase of soil erosion on slopes, the depletion of soil nutrients, an increased transport of nutrients and contaminants attached to sediment particles, their transfer into surface water bodies and consequential negative effects

  1. Massively parallel E-beam inspection: enabling next-generation patterned defect inspection for wafer and mask manufacturing

    Science.gov (United States)

    Malloy, Matt; Thiel, Brad; Bunday, Benjamin D.; Wurm, Stefan; Mukhtar, Maseeh; Quoi, Kathy; Kemen, Thomas; Zeidler, Dirk; Eberle, Anna Lena; Garbowski, Tomasz; Dellemann, Gregor; Peters, Jan Hendrik

    2015-03-01

    SEMATECH aims to identify and enable disruptive technologies to meet the ever-increasing demands of semiconductor high volume manufacturing (HVM). As such, a program was initiated in 2012 focused on high-speed e-beam defect inspection as a complement, and eventual successor, to bright field optical patterned defect inspection [1]. The primary goal is to enable a new technology to overcome the key gaps that are limiting modern day inspection in the fab; primarily, throughput and sensitivity to detect ultra-small critical defects. The program specifically targets revolutionary solutions based on massively parallel e-beam technologies, as opposed to incremental improvements to existing e-beam and optical inspection platforms. Wafer inspection is the primary target, but attention is also being paid to next generation mask inspection. During the first phase of the multi-year program multiple technologies were reviewed, a down-selection was made to the top candidates, and evaluations began on proof of concept systems. A champion technology has been selected and as of late 2014 the program has begun to move into the core technology maturation phase in order to enable eventual commercialization of an HVM system. Performance data from early proof of concept systems will be shown along with roadmaps to achieving HVM performance. SEMATECH's vision for moving from early-stage development to commercialization will be shown, including plans for development with industry leading technology providers.

  2. Dengue virus in sub-tropical northern and central Viet Nam: population immunity and climate shape patterns of viral invasion and maintenance.

    Directory of Open Access Journals (Sweden)

    Maia A Rabaa

    Full Text Available Dengue virus transmission occurs in both epidemic and endemic cycles across tropical and sub-tropical regions of the world. Incidence is particularly high in much of Southeast Asia, where hyperendemic transmission plagues both urban and rural populations. However, endemicity has not been established in some areas with climates that may not support year-round viral transmission. An understanding of how dengue viruses (DENV enter these environments and whether the viruses persist in inapparent local transmission cycles is central to understanding how dengue emerges in areas at the margins of endemic transmission. Dengue is highly endemic in tropical southern Vietnam, while increasingly large seasonal epidemics have occurred in northern Viet Nam over the last decade. We have investigated the spread of DENV-1 throughout Vietnam to determine the routes by which the virus enters northern and central regions of the country. Phylogeographic analysis of 1,765 envelope (E gene sequences from Southeast Asia revealed frequent movement of DENV between neighboring human populations and strong local clustering of viral lineages. Long-distance migration of DENV between human population centers also occurred regularly and on short time-scales, indicating human-mediated viral invasion into northern Vietnam. Human populations in southern Vietnam were found to be the primary source of DENV circulating throughout the country, while central and northern Vietnam acted as sink populations, likely due to reduced connectedness to other populations in the case of the central regions and to the influence of temperature variability on DENV replication and vector survival and competence in the north. Finally, phylogeographic analyses suggested that viral movement follows a gravity model and indicates that population immunity and physical and economic connections between populations may play important roles in shaping patterns of DENV transmission.

  3. Dengue virus in sub-tropical northern and central Viet Nam: population immunity and climate shape patterns of viral invasion and maintenance.

    Science.gov (United States)

    Rabaa, Maia A; Simmons, Cameron P; Fox, Annette; Le, Mai Quynh; Nguyen, Thuy Thi Thu; Le, Hai Yen; Gibbons, Robert V; Nguyen, Xuyen Thanh; Holmes, Edward C; Aaskov, John G

    2013-01-01

    Dengue virus transmission occurs in both epidemic and endemic cycles across tropical and sub-tropical regions of the world. Incidence is particularly high in much of Southeast Asia, where hyperendemic transmission plagues both urban and rural populations. However, endemicity has not been established in some areas with climates that may not support year-round viral transmission. An understanding of how dengue viruses (DENV) enter these environments and whether the viruses persist in inapparent local transmission cycles is central to understanding how dengue emerges in areas at the margins of endemic transmission. Dengue is highly endemic in tropical southern Vietnam, while increasingly large seasonal epidemics have occurred in northern Viet Nam over the last decade. We have investigated the spread of DENV-1 throughout Vietnam to determine the routes by which the virus enters northern and central regions of the country. Phylogeographic analysis of 1,765 envelope (E) gene sequences from Southeast Asia revealed frequent movement of DENV between neighboring human populations and strong local clustering of viral lineages. Long-distance migration of DENV between human population centers also occurred regularly and on short time-scales, indicating human-mediated viral invasion into northern Vietnam. Human populations in southern Vietnam were found to be the primary source of DENV circulating throughout the country, while central and northern Vietnam acted as sink populations, likely due to reduced connectedness to other populations in the case of the central regions and to the influence of temperature variability on DENV replication and vector survival and competence in the north. Finally, phylogeographic analyses suggested that viral movement follows a gravity model and indicates that population immunity and physical and economic connections between populations may play important roles in shaping patterns of DENV transmission.

  4. Contrasting Holocene environmental histories may explain patterns of species richness and rarity in a Central European landscape

    Science.gov (United States)

    Hájek, Michal; Dudová, Lydie; Hájková, Petra; Roleček, Jan; Moutelíková, Jitka; Jamrichová, Eva; Horsák, Michal

    2016-02-01

    The south-western part of the White Carpathians (Czech Republic, Slovakia) is known for its exceptional grassland diversity and occurrence of many species with disjunct distribution patterns, including isolated populations of continental forest-steppe species. The north-eastern part of the mountain range lacks many of these species and has clearly lower maxima of grassland species richness. While climatic and edaphic conditions of both regions largely overlap, their specific environmental history has been hypothesized to explain the exceptional richness in the south-western part. We explored an entire-Holocene record (9650 BC onwards), the first one from the north-eastern part, to find out whether differences in history may explain regional patterns of species rarity and richness. We analysed pollen, macrofossils and molluscs and dated the sequence with 13 radiocarbon dates. We further reconstructed past human activities using available archaeological evidence. Based on this analysis, the Early-Holocene landscape was reconstructed as semi-open with broad-leaved trees (elm and lime) appearing already around 9500 BC. Lime reached a relative abundance of as much as 60% around 8700 BC. All analysed proxies support the existence of dense lime-dominated woodland during the forest optimum starting after climate moistening around 6800 BC, some 2200 years before the first signs of slight forest opening in the Late Neolithic. During the Bronze and Iron Ages, human pressure increased, which led to a decrease in lime and an increase in oak, hornbeam, grasses and grassland snails; nevertheless, forests still dominated the landscape and beech spread when human impact temporarily decreased. Colonisation after AD 1350 created the modern grassland-rich landscape. All available evidence confirmed an early post-Glacial expansion of broad-leaved trees, supporting the hypothesis on their glacial refugia in the Carpathians, as well as presence of closed-canopy forest well before the

  5. Microparticles generated by decompression stress cause central nervous system injury manifested as neurohypophysial terminal action potential broadening

    OpenAIRE

    Yang, Ming; Kosterin, Paul; Salzberg, Brian M.; Milovanova, Tatyana N.; Bhopale, Veena M.; Thom, Stephen R.

    2013-01-01

    The study goal was to use membrane voltage changes during neurohypophysial action potential (AP) propagation as an index of nerve function to evaluate the role that circulating microparticles (MPs) play in causing central nervous system injury in response to decompression stress in a murine model. Mice studied 1 h following decompression from 790 kPa air pressure for 2 h exhibit a 45% broadening of the neurohypophysial AP. Broadening did not occur if mice were injected with the MP lytic agent...

  6. Central Asia in a Changing World: From a Peripheral Region to an Area of Policy Generation and Application. Actors, Policy and Security

    Directory of Open Access Journals (Sweden)

    Nora Sainz Gsell

    2005-10-01

    Full Text Available This work deals with Central Asia, beginning with an analysis of the characteristics of international insertion of the area as a whole and of the former Soviet republics that comprise it. In a general way, it aims to analyse the evolution of Central Asia from a peripheral region to an area that generates behaviours and receives the application of policies on the part ofinternational actors. In the first part of the study, it mentions a series of particularities of the republics that have determined the relationships in the region(the Central Asian order and those between the region and the outside world; it indicates geo-historical and economic-strategic aspects. In the second part, it examines the foreign policy of the republics in the post-Cold War era from the singularities of domestic policy. And, in the third part, it analyses, according to the aforementioned peculiarities, the policies that the area and each State has generated in international actors, both regional ones and global ones, and which have transformed the region from a peripheral one to a geopolitically emerging one.

  7. Formation of sulphation deposits in cables in the electricity generation plant of Los Humeros geothermal field, Mexico; Sulfatacion de cables en la central geotermoelectrica Los Humeros, Puebla, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Vergara Rangel, Agustin [Comision Federal de Electricidad, Perote, Veracruz (Mexico)

    2000-12-01

    In the construction of a central electrical generation plant using geothermal fluids, high quality standards are applied in all aspects of engineering. Los Humeros generation units were installed through trenches, ducts and trays according to norms for cables of control, force and power, specifically in point to point cables and connections. Performance of the power plant has been affected by electric momentary and sequence flaws due to problems of cable sulfating, which were solved by tinning the conductors. [Spanish] En la construccion de centrales generadoras de electricidad con fluidos geotermicos se aplican criterios de calidad de diseno en todos los aspectos de la ingenieria. En Los Humeros Puebla, se realizo la instalacion conforme a normas de cables de control, fuerza y potencia a traves de trincheras, ductos y charolas y especificamente en el cableado asi como en las conexiones de punta a punta. Todos estos aspectos son referidos a planos de los componentes y equipos electricos existentes en una central. Al paso del tiempo existieron fallas electricas momentaneas y secuenciales por el problema de sulfatacion en cables, los cuales fueron resueltos con el estanado de conductores.

  8. Spatial distribution, blood feeding pattern, and role of Anopheles funestus complex in malaria transmission in central Kenya.

    Science.gov (United States)

    Muturi, Ephantus J; Kamau, Luna; Jacob, Benjamin G; Muriu, Simon; Mbogo, Charles M; Shililu, Josephat; Githure, John; Novak, Robert J

    2009-10-01

    Studies were conducted to determine the role of sibling species of Anopheles funestus complex in malaria transmission in three agro-ecosystems in central Kenya. Mosquitoes were sampled indoors and outdoors, and rDNA PCR was successfully used to identify 340 specimens. Anopheles parensis (91.8%), A. funestus (6.8%), and Anopheles leesoni (1.5%) were the three sibling species identified. A. parensis was the dominant species at all study sites, while 22 of 23 A. funestus were collected in the non-irrigated study site. None of the 362 specimens tested was positive for Plasmodium falciparum circumsporozoite proteins by enzyme-linked immunosorbent assay. The most common blood-meal sources (mixed blood meals included) for A. parensis were goat (54.0%), human (47.6%), and bovine (39.7%), while the few A. funestus s.s. samples had fed mostly on humans. The human blood index (HBI) for A. parensis (mixed blood meals included) in the non-irrigated agro-ecosystem was 0.93 and significantly higher than 0.33 in planned rice agro-ecosystem. The few samples of A. funestus s.s. and A. funestus s.l. also showed a trend of higher HBI in the non-irrigated agro-ecosystem. We conclude that agricultural practices have significant influence on distribution and blood feeding behavior of A. funestus complex. Although none of the species was implicated with malaria transmission, these results may partly explain why non-irrigated agro-ecosystems are associated with higher risk of malaria transmission by this species compared to irrigated agro-ecosystems.

  9. Demographic patterns and trends in Central Ghana: baseline indicators from the Kintampo Health and Demographic Surveillance System

    Directory of Open Access Journals (Sweden)

    Seth Owusu-Agyei

    2012-12-01

    Full Text Available Background: The dearth of health and demographic data in sub-Saharan Africa from vital registration systems and its impact on effective planning for health and socio-economic development is widely documented. Health and Demographic Surveillance Systems have the capacity to address the dearth of quality data for policy making in resource-poor settings. Objective: This article demonstrates the utility of the Kintampo Health and Demographic Surveillance System (KHDSS by showing the patterns and trends of population change from 2005 to 2009 in the Kintampo North Municipality and Kintampo South districts of Ghana through data obtained from the KHDSS biannual update rounds. Design: Basic demographic rates for fertility, mortality, and migration were computed by year. School enrolment was computed as a percentage in school by age and sex for 6–18 year-olds. Socio-economic status was derived by use of Principal Components Analysis on household assets. Results: Over the period, an earlier fertility decline was reversed in 2009; mortality declined slightly for all age-groups, and a significant share of working-age population was lost through out-migration. Large minorities of children of school-going age are not in school. Socio-economic factors are shown to be important determinants of fertility and mortality. Conclusion : Strengthening the capacity of HDSSs could offer added value to evidence-driven policymaking at local level.

  10. Comparison of Elementary Educational Facility Allocation Patterns and Planning Strategies in Rural Areas:Case Studies of Central and Eastern China

    Institute of Scientific and Technical Information of China (English)

    Zhao; Min; Shao; Lin; Li; Wei; Qian; Fang

    2016-01-01

    Elementary educational facilities are one of the essential public service facilities in rural China. Based on case studies of two countylevel cities in central and eastern China, this paper explores issues regarding a rational allocation of elementary educational facilities in rural areas, including different allocation patterns and effects, and rural residents’ views on elementary educational facilities, as well as their preference when choosing schools. This paper, on the basis of empirical studies, concludes that relevant policies and planning strategies should be adjusted in accordance with the general trends of rural population being decreasing continuously and the student pool concentrating toward towns, so as to achieve an efficient and fair allocation of elementary educational facilities.

  11. A Comparison of Optimal Operation of a Residential Fuel Cell Co-Generation System Using Clustered Demand Patterns Based on Kullback-Leibler Divergence

    Directory of Open Access Journals (Sweden)

    Takumi Hasizume

    2013-01-01

    Full Text Available When evaluating residential energy systems like co-generation systems, hot water and electricity demand profiles are critical. In this paper, the authors aim to extract basic time-series demand patterns from two kinds of measured demand (electricity and domestic hot water, and also aim to reveal effective demand patterns for primary energy saving. Time-series demand data are categorized with a hierarchical clustering method using a statistical pseudo-distance, which is represented by the generalized Kullback-Leibler divergence of two Gaussian mixture distributions. The classified demand patterns are built using hierarchical clustering and then a comparison is made between the optimal operation of a polymer electrolyte membrane fuel cell co-generation system and the operation of a reference system (a conventional combination of a condensing gas boiler and electricity purchased from the grid using the appropriately built demand profiles. Our results show that basic demand patterns are extracted by the proposed method, and the heat-to-power ratio of demand, the amount of daily demand, and demand patterns affect the primary energy saving of the co-generation system.

  12. Aluminium Accumulation and Intra-Tree Distribution Patterns in Three Arbor aluminosa (Symplocos) Species from Central Sulawesi.

    Science.gov (United States)

    Schmitt, Marco; Boras, Sven; Tjoa, Aiyen; Watanabe, Toshihiro; Jansen, Steven

    2016-01-01

    Accumulation of Aluminium (Al) at concentrations far above 1,000 mg kg-1 in aboveground plant tissues of Arbor aluminosa (Symplocos) species is the main reason why traditional Indonesian weavers rely on their leaves and bark as a mordant for dyeing textile. Recently, Symplocos species have become a flagship species for the conservation efforts of weaving communities due to their traditionally non-sustainable sampling and increasing demand for Symplocos plant material. Here we investigated Symplocos odoratissima, S. ophirensis and S. ambangensis at three montane rainforest sites in Central Sulawesi to measure Al levels in different tissues and organs. The highest Al concentrations were found in old leaves (24,180 ± 7,236 mg·kg-1 dry weight, mean ± SD), while young leaves had significantly lower Al levels (20,708 ± 7,025 mg·kg-1). Al accumulation was also lower in bark and wood tissue of the trunk (17,231 ± 8,356 mg·kg-1 and 5,181 ± 2,032 mg·kg-1, respectively). Two Al excluding species (Syzigium sp. and Lithocarpus sp.) contained only high Al levels in their roots. Moreover, no difference was found in soil pH (4.7 ± 0.61) and nutrient (K, Ca, Fe, Mg) availability at different soil levels and within or outside the crown of Symplocos trees, except for the upper soil layer. Furthermore, a positive and significant correlation between Al and Ca concentrations was found at the whole plant level for Symplocos, and at the leaf level for S. ophirensis and S. ambangensis, suggesting a potential role of Ca in Al uptake and/or detoxification within the plant. Our results provide evidence for strong Al accumulation in Symplocos species and illustrate that both Al accumulation and exclusion represent two co-occurring strategies of montane rainforest plants for dealing with Al toxicity. Indonesian weavers should be encouraged to harvest old leaves, which have the most efficient mordant capacity due to high Al concentrations.

  13. Aluminium Accumulation and Intra-Tree Distribution Patterns in Three Arbor aluminosa (Symplocos Species from Central Sulawesi.

    Directory of Open Access Journals (Sweden)

    Marco Schmitt

    Full Text Available Accumulation of Aluminium (Al at concentrations far above 1,000 mg kg-1 in aboveground plant tissues of Arbor aluminosa (Symplocos species is the main reason why traditional Indonesian weavers rely on their leaves and bark as a mordant for dyeing textile. Recently, Symplocos species have become a flagship species for the conservation efforts of weaving communities due to their traditionally non-sustainable sampling and increasing demand for Symplocos plant material. Here we investigated Symplocos odoratissima, S. ophirensis and S. ambangensis at three montane rainforest sites in Central Sulawesi to measure Al levels in different tissues and organs. The highest Al concentrations were found in old leaves (24,180 ± 7,236 mg·kg-1 dry weight, mean ± SD, while young leaves had significantly lower Al levels (20,708 ± 7,025 mg·kg-1. Al accumulation was also lower in bark and wood tissue of the trunk (17,231 ± 8,356 mg·kg-1 and 5,181 ± 2,032 mg·kg-1, respectively. Two Al excluding species (Syzigium sp. and Lithocarpus sp. contained only high Al levels in their roots. Moreover, no difference was found in soil pH (4.7 ± 0.61 and nutrient (K, Ca, Fe, Mg availability at different soil levels and within or outside the crown of Symplocos trees, except for the upper soil layer. Furthermore, a positive and significant correlation between Al and Ca concentrations was found at the whole plant level for Symplocos, and at the leaf level for S. ophirensis and S. ambangensis, suggesting a potential role of Ca in Al uptake and/or detoxification within the plant. Our results provide evidence for strong Al accumulation in Symplocos species and illustrate that both Al accumulation and exclusion represent two co-occurring strategies of montane rainforest plants for dealing with Al toxicity. Indonesian weavers should be encouraged to harvest old leaves, which have the most efficient mordant capacity due to high Al concentrations.

  14. Sources and the flux pattern of dissolved carbon in rivers of the Yenisey basin draining the Central Siberian Plateau

    Science.gov (United States)

    Prokushkin, A. S.; Pokrovsky, O. S.; Shirokova, L. S.; Korets, M. A.; Viers, J.; Prokushkin, S. G.; Amon, R. M. W.; Guggenberger, G.; McDowell, W. H.

    2011-10-01

    Frequent measurements of dissolved organic (DOC) and inorganic (DIC) carbon concentrations in rivers during snowmelt, the entire ice-free season, and winter were made in five large watersheds (15 000-174 000 km2) of the Central Siberian Plateau (Yenisey River basin). These differ in the degree of continuous permafrost coverage, mean annual air temperature, and the proportion of tundra and forest vegetation. With an annual DOC export from the catchment areas of 2.8-4.7 gC m - 2 as compared to an annual DIC export of 1.0-2.8 gC m - 2, DOC was the dominant component of terrigenous C released to rivers. There was strong temporal variation in the discharge of DOC and DIC. Like for other rivers of the pan-arctic and boreal zones, snowmelt dominated annual fluxes, being 55-71% for water runoff, 64-82% for DOC and 37-41% for DIC. Likewise, DOC and DIC exhibited also a strong spatial variation in C fluxes, with both dissolved C species decreasing from south to north. The rivers of the southern part of the plateau had the largest flow-weighted DOC concentrations among those previously reported for Siberian rivers, but the smallest flow-weighted DIC concentrations. In the study area, DOC and DIC fluxes were negatively correlated with the distribution of continuous permafrost and positively correlated with mean annual air temperature. A synthesis of literature data shows similar trends from west to east, with an eastward decrease of dissolved C concentrations and an increased proportion of DOC in the total dissolved C flux. It appears that there are two contemporary limitations for river export of terrigenous C across Siberia: (1) low productivity of ecosystems with respect to potentially mobilizable organic C, slow weathering rates with concomitant small formation of bicarbonate, and/or wildfire disturbance limit the pools of organic and inorganic C that can be mobilized for transport in rivers (source-limited), and (2) mobilization of available pools of C is constrained by

  15. Stress patterns of the Plio-Quaternary brittle deformation along the Calama-Olacapato-El Toro Fault, Central Andes

    Science.gov (United States)

    Lanza, F.; Tibaldi, A.; Waite, G. P.; Corazzato, C.; Bonali, F.; Nardin, A.

    2012-04-01

    Understanding the geometry and kinematics of the major structures of an orogen is essential to elucidate its style of deformation, as well as its tectonic evolution. We describe the temporal and spatial changes in the state of stress of the trans-orogen area of the Calama-Olacapato-El Toro (COT) Fault Zone in the Central Andes, at about 24° S within the northern portion of the Puna Plateau between the Argentina-Chile border. The importance of the COT derives principally from the Quaternary-Holocene activity recognized on some segments, which may shed new light on its possible control on Quaternary volcanism and on the seismic hazard assessment of the area. Field geological surveys along with kinematic analysis and numerical inversion of ~ 280 new fault-slip measurements have revealed that this portion of the COT consists mainly of NW-SE striking faults, which have been reactivated under three different kinematic regimes: 1) a Miocene transpressional phase with the maximum principal stress (σ1) chiefly trending NW-SE; 2) an extensional phase that started by 9 Ma, with a horizontal NW-SE-trending minimum principal stress (σ3) - permutations between σ2 and σ3 axes have been recognized at three sites - and 3) a left-lateral strike-slip phase with an ~ ENE-WSW σ1 and a ~ NNW-SSE σ3 dating to the late Pliocene-Quaternary. Spatially, in the Quaternary, the left-lateral component decreases toward the westernmost tip of the COT, where it transitions to extension; this produced to a N-S horst and graben structure. Hence, even if trascurrence is still active in the eastern portion of the COT, as focal mechanisms of crustal earthquakes indicate, our study demonstrates that extension is becoming the predominant structural style of deformation, at least in the western region. These major temporal and spatial changes in the tectonic regimes are attributed in part to changes in the magnitude of the boundary forces due to subduction processes. The overall perpendicular

  16. Are Dietary Patterns of Mothers during Pregnancy Related to Childrens Weight Status? Evidence from the Lifeways Cross-Generational Cohort Study

    Directory of Open Access Journals (Sweden)

    Celine M Murrin

    2015-07-01

    Full Text Available Children's diet patterns are likely to be influenced by their mothers' diet pattern. The primary objective of this study was to examine whether children's adiposity could be influenced by diet patterns of mothers during pregnancy. A secondary objective was to study the relative influence of fathers' and children's dietary patterns on childhood adiposity. The design was a prospective cross-generational cohort study initiated with 1,124 mothers recruited during pregnancy. Self-reported questionnaires included a food frequency instrument (FFQ to assess parental intakes during the perinatal period. Child body mass index (BMI was measured at 5 years and an age-appropriate FFQ was administered. Dietary patterns for each group were identified by principal components analysis. Pearson's correlation and logistic regression were used to test for associations. Dietary patterns were described for n = 1,042 mothers during pregnancy and n = 331 fathers during the perinatal period. Dietary patterns and BMI data were available for n = 443 children at age 5 years. The diet patterns identified for mothers correlated with the corresponding diet patterns for fathers. The children's “pasta & vegetable” pattern was positively correlated with “healthy patterns” in mothers (r = 0.195, p < 0.01 and fathers (r = 0.250, p < 0.01. The children's “junk” food pattern was correlated with the “processed” pattern in mothers (r = 0.245, p < 0.01 and fathers (r = 0.257, p < 0.01. In multivariate logistic regression analysis the upper tertiles of children's “cereal and juice” [Tertile 2 (T2: OR 0.44, 95% CI (0.22-0.90; T3: 0.41, (0.19-0.85] and the middle tertile of the “pasta and veg” patterns [T3: 0.37, (0.18-0.75] were negatively associated with overweight and obesity. The mothers' processed pattern during pregnancy was positively associated with offspring overweight and obesity [T2: 2.64, (1.28-5.45; T3: 2.03, (0.87-4.73]. No significant associations

  17. Examining runoff generation processes in the Selke catchment in central Germany: Insights from data and semi-distributed numerical model

    Directory of Open Access Journals (Sweden)

    Sumit Sinha

    2016-09-01

    New hydrological insights for the region: We examined the spatio-temporal variation of runoff generating mechanisms on the sub-basin level on seasonal basis. Our analysis reveals that the runoff generation in the Selke catchment is primarily dominated by shallow sub-surface flow and very rarely the contribution from Dunne overland flow exceeds sub-surface flow. Runoff generated by Hortonian mechanism is very infrequent and almost negligible. We also examined the spatio-temporal variation of runoff coefficients on seasonal basis as well as for individual storms. Due to higher precipitation and topographic relief in the upland catchment of Silberhutte, the runoff coefficients were consistently higher and its peak was found in winter months due to lower evapotranspiration.

  18. 基于拓扑构型的地毯图案生成方法%A Generation Method of Carpet Pattern Based on Topology Configuration

    Institute of Scientific and Technical Information of China (English)

    赵海英; 彭宏; 杨一帆; 徐正光

    2013-01-01

    Traditional fabric patterns generally contain certain basic elements which are characteristically distributed. However, the existing pattern generation methods based on characteristics and examples preserve neither the integrity of elements and structures in pattern, nor the information of styles and levels, such as distribution characteristics. Thus, taking Xinjiang carpet design as an example, an auto-generating method of patterns based on topological structure is presented. By interactively identifying patterns with different perception layers to serve as templates and extracting elements of the same class accurately by template-matching algorithm, pattern topological structure is generated. Then, appropriate patterns are extracted after the design of selection rules. Finally, the matrix mark method is used to embed the pattern. The experimental results show that the method not only solves the overlapping problem of pattern elements, but also generates beautifully-layered patterns that can express the composition, element image and color of the fabric prints, which can meet the design requirements of style inheritance.%传统的织物图案中通常包含按一定特征分布的基本元素,而现有基于特征和实例的图案生成方法难以保持图案中基本纹样元素与结构特征的完整性以及分布特征等基于风格层次的信息.文中以新疆地毯图案为例,提出一种基于拓扑构型的图案自动生成方法.将交互标识出的不同感知层的图案元素作为模板,并约束模板匹配算法较准确地提取同类图案元素,生成图案拓扑构型;再设计选择规则,提取合适的图案纹样.最后利用所提出的标识矩阵法进行纹样嵌图,结果表明,该方法不仅解决了图案元素重叠的问题,而且能生成体现织物图案的构图、元素形象和色彩的具有层次美感的图案,满足风格传承的设计要求.

  19. A Priori and a Posteriori Dietary Patterns during Pregnancy and Gestational Weight Gain: The Generation R Study.

    Science.gov (United States)

    Tielemans, Myrte J; Erler, Nicole S; Leermakers, Elisabeth T M; van den Broek, Marion; Jaddoe, Vincent W V; Steegers, Eric A P; Kiefte-de Jong, Jessica C; Franco, Oscar H

    2015-11-12

    Abnormal gestational weight gain (GWG) is associated with adverse pregnancy outcomes. We examined whether dietary patterns are associated with GWG. Participants included 3374 pregnant women from a population-based cohort in the Netherlands. Dietary intake during pregnancy was assessed with food-frequency questionnaires. Three a posteriori-derived dietary patterns were identified using principal component analysis: a "Vegetable, oil and fish", a "Nuts, high-fiber cereals and soy", and a "Margarine, sugar and snacks" pattern. The a priori-defined dietary pattern was based on national dietary recommendations. Weight was repeatedly measured around 13, 20 and 30 weeks of pregnancy; pre-pregnancy and maximum weight were self-reported. Normal weight women with high adherence to the "Vegetable, oil and fish" pattern had higher early-pregnancy GWG than those with low adherence (43 g/week (95% CI 16; 69) for highest vs. lowest quartile (Q)). Adherence to the "Margarine, sugar and snacks" pattern was associated with a higher prevalence of excessive GWG (OR 1.45 (95% CI 1.06; 1.99) Q4 vs. Q1). Normal weight women with higher scores on the "Nuts, high-fiber cereals and soy" pattern had more moderate GWG than women with lower scores (-0.01 (95% CI -0.02; -0.00) per SD). The a priori-defined pattern was not associated with GWG. To conclude, specific dietary patterns may play a role in early pregnancy but are not consistently associated with GWG.

  20. Patterns of diversity and abundance of carrion insect assemblages in the Natural Park "Hoces del Río Riaza" (central Spain).

    Science.gov (United States)

    Baz, Arturo; Cifrián, Blanca; Martín-Vega, Daniel

    2014-01-01

    The patterns of diversity and abundance of the carrion insect species in the different habitats of the Natural Park "Hoces del Río Riaza" (central Spain) were studied with the use of carrion-baited traps. Representativeness of the inventories was assessed with the calculation of randomized species richness curves and nonparametric estimators. Coleoptera families, Silphidae and Dermestidae, and Diptera families, Calliphoridae and Muscidae, were dominant in every sampling habitat, but differences in the patterns of diversity and abundance were found. Lusitanian oakwood and riparian forest were the most diverse habitats with high abundance of saprophagous species, whereas more open (i.e., exposed to continuous sunlight during the day) habitats showed lower diversity values and a different species composition and distribution of species abundance, favoring thermophilous species and necrophagous species with high tolerance to different environmental conditions. Differences in the bioclimatical features of the sampled habitats are suggested to explain the composition and diversity of the carrion insect assemblages in different environments.

  1. Effects of projected climate change on the glacier and runoff generation in the Naryn River Basin, Central Asia

    Science.gov (United States)

    Gan, Rong; Luo, Yi; Zuo, Qiting; Sun, Lin

    2015-04-01

    Climate change is a major environmental concern and the melting processes of the glaciers and snowpacks are sensitive to climate change. The ultimate effect of the future changes on the glacier and hydrology is unclear and poorly investigated for Central Asia. Here, we use results from the latest ensemble of climate models in combination with a glacier-enhanced Soil Water Assessment Tool (SWAT) hydrologic model to assess the hydrological impact of climate change in the Naryn River Basin, Central Asia. Results indicate that small glaciers suffer from larger relative area losses than large glaciers. Only 8% of the originally glaciated area for small glaciers will retain glaciers by 2100 for RCP8.5. The rate of area retreat for small glaciers (with an area change in precipitation, snowmelt and higher evapotranspiration. Glacier melt is mainly derived by future temperature changes, while the runoff and snowmelt component are determined by future precipitation. The timing of peak runoff is advancing about one month as a result of earlier snowmelt due to the warming temperature. Runoff is projected to increase during the spring and decrease for the summer season for the future periods. Thus water availability on the time will likely undergo significant changes.

  2. A model of co-occurrence: segregation and aggregation patterns in the mycoflora of the crayfish Procambarus clarkii in Lake Trasimeno (central Italy

    Directory of Open Access Journals (Sweden)

    Antonia C. Elia

    2012-01-01

    Full Text Available Although attention on crayfish diseases has recently proliferated, the focus is mainly on a single host-parasite relationship rather than analyzing the entire mycoflora, probably due to the fact that (1 some diseases are occasional (pathogens of which are of difficult collection and (2 economic impact is more relevant in aquaculture (i.e., a controlled environment where only few parasites occur than in natural conditions. Contrary to this viewpoint, fungal ectoparasites assume a great importance since they are integral components in shaping community, ecosystem structure, and energy flow. Here we described the fungal species co-occurrence patterns (species segregation/ aggregation using null models comparing the occurrence frequencies of ectosymbiots through host individuals with those expected by chance. Non-indigenous crayfish species like Procambarus clarkii allow to observe phenomena of competitive exclusion (segregation or mutualism (aggregation amongst fungi. We analyzed the fungal species occurrence on 86 host crayfish monthly collected from June 2007 to June 2008 in the Lake Trasimeno (Central Italy. A total of 29 fungal taxa were detected. Taxa showed a particular fungal assemblage with a great species variation depending on sampling month and crayfish sex, size, and body region. In particular, fungal species showed different occurrence patterns in both richness and segregation/ aggregation. The fungal community shows a non-random structure not in all cases, with the majority of tests indicating segregation, not aggregation of ectosymbiontic species on hosts. The non-random patterns of fungal co-occurrence in some cases suggest that some temporally or spatially variable factors are responsible for the establishment of the mycoflora community assemblage. We also detected temporal differences in fungal co-occurrences patterns. Regarding seasonal samples, the same analyses showed a competitive structure only in the sub-communities found on

  3. Generational changes in materialism and work centrality, 1976-2007: associations with temporal changes in societal insecurity and materialistic role modeling.

    Science.gov (United States)

    Twenge, Jean M; Kasser, Tim

    2013-07-01

    We examined whether culture-level indices of threat, instability, and materialistic modeling were linked to the materialistic values of American 12th graders between 1976 and 2007 (N = 355,296). Youth materialism (such as the importance of money and of owning expensive material items) increased over the generations, peaking in the late 1980s to early 1990s with Generation X and then staying at historically high levels for Millennials (GenMe). Societal instability and disconnection (e.g., unemployment, divorce) and social modeling (e.g., advertising spending) had both contemporaneous and lagged associations with higher levels of materialism, with advertising most influential during adolescence and instability during childhood. Societal-level living standards during childhood predicted materialism 10 years later. When materialistic values increased, work centrality steadily declined, suggesting a growing discrepancy between the desire for material rewards and the willingness to do the work usually required to earn them.

  4. Satellite-measured interannual variability of turbid river plumes off central-southern Chile: Spatial patterns and the influence of climate variability

    Science.gov (United States)

    Saldías, Gonzalo S.; Largier, John L.; Mendes, Renato; Pérez-Santos, Iván; Vargas, Cristian A.; Sobarzo, Marcus

    2016-08-01

    Ocean color imagery from MODIS (Moderate Resolution Imaging Spectroradiometer) onboard the Aqua platform is used to characterize the interannual variability of turbid river plumes off central-southern Chile. Emphasis is placed on the influence of climate fluctuations, namely El Niño Southern Oscillation (ENSO), the Pacific Decadal Oscillation (PDO), and the Antarctic Oscillation (AAO). Additional satellite data on wind, boat-based hydrographic profiles, and regional climate indices are used to identify the influence of climate variability on the generation of anomalous turbid river plumes. The evolution of salinity at a coastal station on the 90 m isobath between the Itata and Biobío Rivers shows a freshwater surface layer with salinity importance of long-term and high-resolution ocean color observations for studying the temporal evolution of river plumes.

  5. Erosividade e padrões hidrológicos de precipitação no Agreste Central pernambucano Erosivity and rainfall hydrological patterns in the Pernambuco Central 'Agreste'

    Directory of Open Access Journals (Sweden)

    Thais E. M. dos Santos

    2012-08-01

    Full Text Available A principal forma de erosão nas condições brasileiras é a causada pela energia cinética do impacto das gotas de chuva sobre a superfície do solo, desencadeando o processo de erosão hídrica. Desenvolveu-se o presente trabalho com o objetivo de avaliar o índice de erosividade (EI30 e caracterizar o padrão hidrológico das chuvas do Agreste Central pernambucano, considerando-se uma série de 29 anos de dados, ficando patente que o primeiro semestre do ano é caracterizado pela ocorrência de chuvas de elevado potencial erosivo. O valor do fator "R" da equação universal de perda de solo para a região estudada é de 2.779,79 MJ mm ha-1 h-1. O padrão de chuva de maior ocorrência é o avançado, seguido do intermediário e atrasado, com 46,57; 36,38 e 17,19% dos totais de chuvas erosivas analisados, respectivamente. Não foram encontradas correlações significativas entre erosividade, coeficiente de chuva e precipitação.The main form of erosion in Brazilian conditions is caused by the kinetic energy of the impact of raindrops on the soil surface, triggering the erosion process. The present study was conducted with the aim to evaluate the erosivity index (EI30, as well as to characterize the hydrological pattern of rainfall in the Pernambuco Central 'Agreste', considering a series of 29 years of data. It was found that the first half of the year is characterized by rain with high erosive potential. The value of the factor "R" in the Universal equation of soil loss for the studied region is 2,779.79 MJ mm ha-1 h-1. The rain pattern of higher occurrence is the advanced, followed by intermediate and delayed, with 46.57; 36.38 and 17.19% of total erosive rainfall analyzed, respectively. There were no significant correlations between erosivity, rainfall coefficient and precipitation.

  6. GEODYNAMICS OF NAZCA RIDGE’S OBLIQUE SUBDUCTION AND MIGRATION - IMPLICATIONS FOR TSUNAMI GENERATION ALONG CENTRAL AND SOUTHERN PERU: Earthquake and Tsunami of 23 June 2001

    Directory of Open Access Journals (Sweden)

    George Pararas-Carayannis

    2012-01-01

    Full Text Available Peru is in a region of considerable geologic and seismic complexity. Thrust faulting along the boundary where the Nazca plate subducts beneath the South American continent has created three distinct seismic zones. The angle of subduction of the Nazca oceanic plate beneath the South American plate is not uniform along the entire segment of the Peru-Chile Trench. Furthermore, subduction is affected by buoyancy forces of the bounding oceanic ridges and fractures - such as the Mendana Fracture Zone (MFZ to the North and the Nazca Ridge to the South. This narrow zone is characterized by shallow earthquakes that can generate destructive tsunamis of varied intensities. The present study examines the significance of Nazca Ridge’s oblique subduction and migration to the seismicity of Central/Southern Peru and to tsunami generation. The large tsunamigenic earthquake of 23 June 2001 is presented as a case study. This event generated a destructive, local tsunami that struck Peru’s southern coasts with waves ranging from 3 to 4.6 meters (10-15 feet and inland inundation that ranged from 1 to 3 km. In order to understand the near and far-field tsunamigenic efficiency of events along Central/Southern Peru and the significance of Nazca Ridge’s oblique subduction, the present study examines further the geologic structure of the region and this quake’s moment tensor analysis, energy release, fault rupture and the spatial distribution of aftershocks. Tsunami source mechanism characteristics for this event are presented, as inferred from seismic intensities, energy releases, fault plane solutions and the use of empirical relationships. The study concludes that the segment of subduction and faulting paralleling the Peru-Chile Trench from about 150 to 180 South, as well as the obliquity of convergent tectonic plate collision in this region, may be the reason for shorter rupture lengths of major earthquakes and the generation of only local destructive tsunamis.

  7. A Priori and a Posteriori Dietary Patterns during Pregnancy and Gestational Weight Gain: The Generation R Study

    Directory of Open Access Journals (Sweden)

    Myrte J. Tielemans

    2015-11-01

    Full Text Available Abnormal gestational weight gain (GWG is associated with adverse pregnancy outcomes. We examined whether dietary patterns are associated with GWG. Participants included 3374 pregnant women from a population-based cohort in the Netherlands. Dietary intake during pregnancy was assessed with food-frequency questionnaires. Three a posteriori-derived dietary patterns were identified using principal component analysis: a “Vegetable, oil and fish”, a “Nuts, high-fiber cereals and soy”, and a “Margarine, sugar and snacks” pattern. The a priori-defined dietary pattern was based on national dietary recommendations. Weight was repeatedly measured around 13, 20 and 30 weeks of pregnancy; pre-pregnancy and maximum weight were self-reported. Normal weight women with high adherence to the “Vegetable, oil and fish” pattern had higher early-pregnancy GWG than those with low adherence (43 g/week (95% CI 16; 69 for highest vs. lowest quartile (Q. Adherence to the “Margarine, sugar and snacks” pattern was associated with a higher prevalence of excessive GWG (OR 1.45 (95% CI 1.06; 1.99 Q4 vs. Q1. Normal weight women with higher scores on the “Nuts, high-fiber cereals and soy” pattern had more moderate GWG than women with lower scores (−0.01 (95% CI −0.02; −0.00 per SD. The a priori-defined pattern was not associated with GWG. To conclude, specific dietary patterns may play a role in early pregnancy but are not consistently associated with GWG.

  8. Soil cover patterns and SOC dynamics impacts on the soil processes, land management and ecosystem services in Central Region of Russia

    Science.gov (United States)

    Vasenev, Ivan; Chernikov, Vladimir; Yashin, Ivan; Geraskin, Mikhail; Morev, Dmitriy

    2014-05-01

    In the Central Region of Russia (CRR) the soil cover patterns usually play the very important role in the soil forming and degradation processes (SFP & SDP) potential and current rates, soil organic carbon (SOC) dynamics and pools, greenhouse gases (GHG) emissions and soluble SOC fluxes that we need take into attention for better assessment of the natural and especially man-changed ecosystems' services and for best land-use practices development. Central Region of Russia is the biggest one in RF according to its population and role in the economy. CRR is characterized by high spatial variability of soil cover due to as original landscape heterogeneity as complicated history of land-use practices during last 700 years. Our long-term researches include the wide zonal-provincial set of representative ecosystems and soil cover patterns with different types and history of land-use (forest, meadow-steppe and agricultural ones) from middle-taiga to steppe zones with different level of continentality. The carried out more than 30-years region- and local-scale researches of representative natural and rural landscapes in Tver', Yaroslavl', Kaluga, Moscow, Vladimir, Saransk (Mordovia), Kursk, Orel, Tambov, Voronezh and Saratov oblasts give us the interregional multi-factorial matrix of elementary soil cover patterns (ESCP) with different soil forming and degradation processes rates and soil organic carbon dynamics due to regionally specific soil-geomorphologic features, environmental and dominated microclimate conditions, land-use current practices and history. The validation and ranging of the limiting factors of SFP and SDP develop¬ment, soil carbon dynamics and sequestration potential, ecosystem (agroecosystem) principal services, land functional qualities and agroecological state have been done for dominating and most dynamical components of ESCP regional-typological forms - with application of SOC structure analysis, regional and local GIS, soil spatial patterns detail

  9. Recent results from extreme ultraviolet lithography patterned mask inspection for 11 nm half-pitch generation using projection electron microscope system

    Science.gov (United States)

    Hirano, Ryoichi; Iida, Susumu; Amano, Tsuyoshi; Watanabe, Hidehiro; Hatakeyama, Masahiro; Murakami, Takeshi; Suematsu, Kenichi; Terao, Kenji

    2016-05-01

    Extreme ultraviolet lithography (EUVL) is a promising technique for 1X nm half-pitch (hp) generation lithography. The inspection of patterned EUVL masks is one of the main issues that must be addressed during mask fabrication for manufacture of devices with 11 nm hp feature sizes. We have already designed projection electron microscope (PEM) optics that have been integrated into a new inspection system called Model EBEYE-V30 (where "Model EBEYE" is an EBARA's model code) and this system seems quite promising for 16 nm hp generation EUVL patterned mask inspection. The defect inspection sensitivity of this system was evaluated via capture of an electron image that was generated at the mask by focusing the image through the projection optics onto a time-delay integration (TDI) image sensor. For increased throughput and higher defect detection sensitivity, a new electron-sensitive area image sensor with a high-speed data processing unit, a bright and stable electron source, and a simultaneous deflector for the image capture area that follows the mask scanning motion have been developed. Using a combination of synchronous deflection and mask scanning, the image can be integrated into both the fixed area image sensor and the TDI image sensor. We describe our experimental results for EUV patterned mask inspection using the above system. Elements have been developed for inspection tool integration and the designed specification has been verified. The system performance demonstrates the defect detectability required for 11 nm hp generation EUVL masks.

  10. Alternative mRNA Splicing from the Glial Fibrillary Acidic Protein (GFAP) Gene Generates Isoforms with Distinct Subcellular mRNA Localization Patterns in Astrocytes

    DEFF Research Database (Denmark)

    Thomsen, Rune; Daugaard, Tina Fuglsang; Holm, Ida E;

    2013-01-01

    The intermediate filament network of astrocytes includes Glial fibrillary acidic protein (Gfap) as a major component. Gfap mRNA is alternatively spliced resulting in generation of different protein isoforms where Gfapa is the most predominant isoform. The Gfapd isoform is expressed in proliferating......RNA localization patterns were dependent on the different 39-exon sequences included in Gfapd and Gfapa mRNA. The presented results show that alternative Gfap mRNA splicing results in isoform-specific mRNA localization patterns with resulting different local mRNA concentration ratios which have potential...

  11. Control of spatially patterned synchrony with multisite delayed feedback

    OpenAIRE

    Hauptmann, C.; Omelchenko, O.; Popovych, O. V.; Maistrenko, Y.; Tass, P.A.

    2007-01-01

    We present an analytical study describing a method for the control of spatiotemporal patterns of synchrony in networks of coupled oscillators. Delayed feedback applied through a small number of electrodes effectively induces spatiotemporal dynamics at minimal stimulation intensities. Different arrangements of the delays cause different spatial patterns of synchrony, comparable to central pattern generators (CPGs), i.e., interacting clusters of oscillatory neurons producing patterned output, e...

  12. Patterns of soil carbon and nitrogen in relation to soil movement under different land uses in mountain farmland fields (South Central Pyrenees)

    Science.gov (United States)

    Navas, A.; Gaspar, L.; López-Vicente, M.; Machín, J.

    2009-04-01

    Cultivation on mountain landscapes has been identified as a main factor triggering soil erosion. The loss of soil particles and its redistribution across the landscape is associated to that of soil nutrients. Patterns of soil erosion and of the transport and redistribution of soil particles appear to be closely linked to that of carbon in soils. In this work the redistribution of total organic carbon and nitrogen and that of soil particles is analysed in different geomorphic parts of mountain farmland fields. A southern orientated hillslope in the Central Spanish Pyrenees was selected as representative of main land uses. In the region, farmland abandonment during the last decades affects 74 % of its surface and therefore patterns of soil and nutrient losses in the fields are affected by land abandonments and tillage. A set of cultivated and abandoned fields with different ages of land abandonment, slope gradients and length were selected to conduct this study. In each of the fields, sampling was carried out in different parts of the slope to assess the pattern of particle size distribution and of total organic carbon (TOC) and total nitrogen (TN). Other general soil properties analysed: pH, EC and carbonate contents provided supplementary information for better understanding soil and nutrient redistribution patterns. In addition, information provided by a previous research using fallout caesium 137 was used to document soil movement in these fields. At the bottom slope of the fields significant increases in the sand percentage occurs whereas the clay contents decrease slightly. This could be due to the export of the finest fractions with high runoff in spite that fields are surrounded with stone walls as well as to some clay leaching in the soil profile, as suggested by the lowest values of EC at the bottom of the slope. The results indicate that in general TOC increases from the crest to the bottom slope of the fields. Percentages of TOC increases range from 5 to

  13. McKay's observation and vertex operator algebras generated by two conformal vectors of central charge 1/2

    OpenAIRE

    2005-01-01

    This paper is a continuation of our paper math.QA/0403010 at which several coset subalgebras of the lattice VOA $V_{\\sqrt{2}E_8}$ were constructed and the relationship between such algebras with the famous McKay observation on the extended E_8 diagram and the Monster simple group were discussed. In this article, we shall provide the technical details. We completely determine the structure of the coset subalgebras constructed and show that they are all generated by two conformal vectors of cen...

  14. A novel Beam-Down System for Solar Power Generation with Multi-Ring Central Reflectors and Molten Salt Thermal Storage

    Energy Technology Data Exchange (ETDEWEB)

    Tamaura, Y.; Utamura, M.; Kaneko, H.; Hasuike, H.; Domingo, M.; Relloso, S.

    2006-07-01

    A new concept of beam-down solar power with thermal storage is proposed. The system is featured in an optical system with multi-ring central reflectors and a liquid film molten salt thermal receiver installed near ground level. Its feasibility study has been carried out and power generation cost as well as EPC cost has been estimated. To compensate the drawback to a beam-down solar concentrating system in optical losses, a new receiver concept of liquid film molten salt thermal receiver is designed to aim at higher thermal efficiency than that of tubular receiver. Molten salt liquid film is formed along the inner surface of the receiver wall. The liquid film flows down by gravity. It is shown that the liquid film receiver has a high heat exchange potential up to 2MW/m2 of solar beam flux on the inner wall surface and proved to be feasible. Assuming 24 hour continuous power generation located at Almeria Spain, conceptual designs for two capacities of 120MWt (commercial plant) and 20MWt (pilot plant) have been made. The height and the radius of the central receiver have been optimized as a result of trade off of optical loss and the cost of the central reflector and its support structure. The total cost of the Beam-Down will become 8.37 US cents/kWh, which will be competitive with coal and natural gas, when crude oil cost increases. TITECH (Tokyo Institute of Technology) plans to launch an international program to develop the innovative/cheaper solar tower beam--down concentrating system. (Author)

  15. Methodology for generation of heliostat field layout in central receiver systems based on yearly normalized energy surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, Marcelino; Romero, Manuel [DER-Plataforma Solar de Almeria, CIEMAT, Avda. Complutense 22, E-28040 Madrid (Spain)

    2006-07-15

    The heliostat field layout is an essential task for any solar tower plant optimization process. Radially staggered and other distributions are usually optimised by computer codes using different approaches. In most of those cases, due to the CPU time required, the heliostat field layout is optimised by several mathematical models and simplifications. With today's computers, it is possible to calculate the yearly energy available at any point in a site for a given tower height, the yearly normalized energy surface (YNES). Yearly efficiency maps can be generated based on the cosine factor, the spillage factor and the atmospheric attenuation coefficient of the site using real Direct Normal Irradiance (DNI) data, within a reasonable computing time. It is therefore easy to find the place where the yearly energy available is the highest for location of the first heliostat. It is also possible to calculate the effect of shadowing and blocking by this heliostat on the YNES, so YNES can be re-calculated and the best position for the next heliostat can be found. Although this iterative method is time-consuming, it is worthwhile if either the efficiency of the solar plant can be increased or the capital cost reduced. This YNES-based layout generation method enables better flexibility than pre-determined gridding strategies such as used in DELSOL. The paper includes a description of the optimization procedure. (author)

  16. Nearshore human interventions reverse patterns of decline in lake calcium budgets in central Ontario as demonstrated by mass-balance analyses

    Science.gov (United States)

    Yao, Huaxia; McConnell, Christopher; Somers, Keith M.; Yan, Norman D.; Watmough, Shaun; Scheider, Wolfgang

    2011-06-01

    Calcium (Ca) has declined to levels threatening aquatic biota in lakes on the eastern Canadian Shield. Predictive models for future changes in lake Ca are generally based on catchment-scale studies, but these models rarely account for unmeasured sources of Ca supply that are common in the nearshore areas of developed lakes. In this study we utilize up to 29 years of hydrological and water chemistry data for three lakes in central Ontario that differ in degree of human intervention to demonstrate that shoreline development may exert large effects on Ca mass balances. In the relative absence of shoreline development, Red Chalk Lake exhibited what we consider to be the normal response, a reduction in Ca load from the catchment over the last three decades, leading to a reduction in lake export and lake Ca concentration. Calcium load, export, and lake water Ca concentration also fell in Harp Lake, but less than in Red Chalk Lake, because Ca loads were elevated by human activities in Harp Lake's moderately developed shoreline area. By contrast, Dickie Lake experienced an exceptional change in Ca dynamics: both export and lake concentrations rose because of elevated load from the shoreline area linked to the use of dust suppressants on gravel roads. Reductions in both stream Ca concentration and flow volume have led to calcium decline in streams and lakes. Long-term soil acidification processes and climatic variability with its link to hydrology can explain the general pattern of Ca decline in lakes on the south-central Canadian Shield. However, given the widespread lakeshore development and use of dust suppressants on gravel roads, predictions of lake Ca levels need to take into account nearshore activities, especially those that augment rates of Ca supply.

  17. Neem leaf glycoprotein promotes dual generation of central and effector memory CD8(+) T cells against sarcoma antigen vaccine to induce protective anti-tumor immunity.

    Science.gov (United States)

    Ghosh, Sarbari; Sarkar, Madhurima; Ghosh, Tithi; Guha, Ipsita; Bhuniya, Avishek; Saha, Akata; Dasgupta, Shayani; Barik, Subhasis; Bose, Anamika; Baral, Rathindranath

    2016-03-01

    We have previously shown that Neem Leaf Glycoprotein (NLGP) mediates sustained tumor protection by activating host immune response. Now we report that adjuvant help from NLGP predominantly generates CD44(+)CD62L(high)CCR7(high) central memory (TCM; in lymph node) and CD44(+)CD62L(low)CCR7(low) effector memory (TEM; in spleen) CD8(+) T cells of Swiss mice after vaccination with sarcoma antigen (SarAg). Generated TCM and TEM participated either to replenish memory cell pool for sustained disease free states or in rapid tumor eradication respectively. TCM generated after SarAg+NLGP vaccination underwent significant proliferation and IL-2 secretion following SarAg re-stimulation. Furthermore, SarAg+NLGP vaccination helps in greater survival of the memory precursor effector cells at the peak of the effector response and their maintenance as mature memory cells, in comparison to single modality treatment. Such response is corroborated with the reduced phosphorylation of FOXO in the cytosol and increased KLF2 in the nucleus associated with enhanced CD62L, CCR7 expression of lymph node-resident CD8(+) T cells. However, spleen-resident CD8(+) T memory cells show superior efficacy for immediate memory-to-effector cell conversion. The data support in all aspects that SarAg+NLGP demonstrate superiority than SarAg vaccination alone that benefits the host by rapid effector functions whenever required, whereas, central-memory cells are thought to replenish the memory cell pool for ultimate sustained disease free survival till 60 days following post-vaccination tumor inoculation.

  18. Patterns of land-snail succession in Central Europe over the last 15,000 years: main changes along environmental, spatial and temporal gradients

    Science.gov (United States)

    Juřičková, Lucie; Horsák, Michal; Horáčková, Jitka; Abraham, Vojtěch; Ložek, Vojen

    2014-06-01

    Land snail shell assemblages have been used since the pioneering days of palaeoecology to describe Quaternary environmental changes. Despite the many advantages of this proxy, it has recently been rather overlooked. There are more than 300 mollusc successions from localities throughout the Czech and Slovak Republics, making this a globally unique archive. We selected 91 of these successions for radiocarbon dating and further detailed processing. Based on analyses of 828 mollusc assemblages we found a significant increase in both total species richness and number of forest species since the Lateglacial, with a decrease in both after the Middle Holocene. In contrast, the opposite response was found for open-country species and the proportion of xerophilous species. The proportion of forest and open-country species reversed at the Pleistocene/Holocene transition (approx. 11,500 cal yrs BP). Changes in species richness were rather stable across the study area and at different elevation, contrary to changes in species composition. MDS ordination based on presence/absence data show four main patterns of species composition associated with the number of forest species in a sample, position of site along the west-east direction, the proportion of hygrophilous species and, finally, with the age of the mollusc assemblage. The number of forest species indicates the main pattern of changes in the composition of Central European land snail assemblages from the Lateglacial to the present. We confirmed the application and temporal stability of ecological groups of snails as a useful tool for reconstruction of the terrestrial palaeoenvironment.

  19. A Simulation Experiment on a Built-In Self Test Equipped with Pseudorandom Test Pattern Generator and Multi-Input Shift Register (MISR

    Directory of Open Access Journals (Sweden)

    Afaq Ahmad

    2010-12-01

    Full Text Available This paper investigates the impact of the changes of the characteristic polynomials and initial loadings, on behaviour of aliasing errors of parallel signature analyzer (Multi-Input Shift Register, used in an LFSR based digital circuit testing technique. The investigation is carried-out through an extensive simulation study of the effectiveness of the LFSR based digital circuit testing technique. The results of the study show that when the identical characteristic polynomials of order n are used in both pseudo-random test-pattern generator, as well as in Multi-Input Shift Register (MISR signature analyzer (parallel type then the probability of aliasing errors remains unchanged due to the changes in the initial loadings of the pseudo-random test-pattern generator.

  20. Associations between forest fragmentation patterns and geneticstructure in Pfrimer’s Parakeet (Pyrrhura pfrimeri), an endangered endemic to central Brazil’s dry forests

    Science.gov (United States)

    Haig, Susan M.; Miller, Leonard F.; Bianchi, Carlos; Mullins, Thomas D.

    2012-01-01

    When habitat becomes fragmented, populations of species may become increasingly isolated. In the absence of habitat corridors, genetic structure may develop and populations risk reductions in genetic diversity from increased genetic drift and inbreeding. Deforestation of the Cerrado biome of Brazil, particularly of the dry forests within the Parana˜ River Basin, has incrementally occurred since the 1970s and increased forest fragmentation within the region. We performed landscape genetic analyses of Pfrimer’s parakeet (Pyrrhura pfrimeri), a globally endangered endemic to the region, to determine if forest fragmentation patterns were associated with genetic structuring in this species. We used previously generated satellite imagery that identified the locations of Parana˜ River Basin forest fragments in 1977, 1993/94, and 2008. Behavioral data quantifying the affinity of Pfrimer’s parakeet for forest habitat was used to parameterize empirically derived landscape conductance surfaces. Though genetic structure was observed among Pfrimer’s parakeet populations, no association between genetic and geographic distance was detected. Likewise, least cost path lengths, circuit theorybased resistance distances, and a new measure of least cost path length complexity could not be conclusively associated with genetic structure patterns. Instead, a new quantity that encapsulated connection redundancy from the 1977 forest fragmentation data provided the clearest associations with pairwise genetic differentiation patterns (Jost’s D: r = 0.72, P = 0.006; FST: r = 0.741, P = 0.001). Our analyses suggest a 35-year or more lag between deforestation and its effect on genetic structure. Because 66 % of the Parana˜ River Basin has been deforested since 1977, we expect that genetic structure will increase substantially among Pfrimer’s Parakeet populations in the future, especially if fragmentation continues at its current pace.

  1. Numerical analysis of near and far field patterns of second-harmonic generation with tiling nonlinear optical crystals

    Energy Technology Data Exchange (ETDEWEB)

    Harimoto, T [Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 4-3-11 Kofu, Yamanashi 400-8511 (Japan); Shiraga, H [Institute of Laser Engineering, Osaka University, Suita, Osaka (Japan)], E-mail: harimoto@yamanashi.ac.jp

    2008-05-01

    We report numerical analysis of near- and far-field patterns of the second-harmonic wave in a large-scale high-power laser used in the laser fusion with type I KDP crystals arranged in a tiling style. The thickness and phase-matching angle of the tiling crystals are designed based on the near-field pattern of the second-harmonic wave. The tilting angle error and thickness difference of the tiling crystals are evaluated by the energy distribution included in the Airy spot of the far-field pattern at the focal point. The parallelism and flatness of the tiling crystals can also be estimated with the same method.

  2. Role of dietary patterns, sedentary behaviour and overweight of the longditudinal development of childhood constipation: The generation R Study

    NARCIS (Netherlands)

    Kiefte-de Jong, J.C.; Vries, de J.H.M.; Escher, J.; Jaddoe, V.W.; Hofman, M.K.; Raat, H.; Moll, H.

    2013-01-01

    The influence of childhood nutrition on the development of constipation beyond the period of weaning and breastfeeding is relatively understudied. In addition, eating patterns in childhood can be highly correlated with overweight and sedentary behaviour, which may also have an influence on constipat

  3. Role of dietary patterns, sedentary behaviour and overweight on the longitudinal development of childhood constipation: the Generation R study.

    Science.gov (United States)

    Kiefte-de Jong, Jessica C; de Vries, Jeanne H; Escher, Johanna C; Jaddoe, Vincent W V; Hofman, Albert; Raat, Hein; Moll, Henriette A

    2013-10-01

    The influence of childhood nutrition on the development of constipation beyond the period of weaning and breastfeeding is relatively understudied. In addition, eating patterns in childhood can be highly correlated with overweight and sedentary behaviour, which may also have an influence on constipation. The aim of this study was to assess whether common dietary patterns, sedentary behaviour and childhood overweight are associated with constipation in childhood. The study was embedded in a population-based prospective birth cohort. Information on dietary intake was obtained by a food frequency questionnaire at the child's age of 14 months (n = 2420). The adherence scores on a 'Health conscious' and 'Western-like' diet were extracted from principal component analysis. At the age of 24, 36 and 48 months, information on constipation and sedentary behaviour, and weight and height was obtained by parental-derived questionnaires and from the child health centres, respectively. Adherence to a 'Western-like' dietary pattern was associated with a higher prevalence of constipation up to 48 months [adjusted odds ratio (aOR); 95% confidence interval (CI): 1.39; 1.02-1.87], which was not mediated by overweight or sedentary behaviour. Adherence to a 'Health Conscious' dietary pattern was only associated at short term, with a lower prevalence of constipation at 24 months (aOR; 95%CI: 0.65; 0.44-0.96). No association was found between overweight, sedentary behaviour and constipation. Our results suggest that specific dietary patterns in early childhood could be associated with higher or lower risks for constipation, but these effects are time-dependent. Overweight and sedentary behaviour seem to not have a major role on constipation in childhood.

  4. Evidence of binary division in mature central capsules of a collosphaerid colonial radiolarian: Implications for shell ontogenetic patterns in modern and fossil species

    Digital Repository Service at National Institute of Oceanography (India)

    Anderson, O.R.; Gupta, S.M.

    Evidence is presented from fossil shells and living species of the colonial radiolarian Acrosphaera that maturer central capsules with shells can produce daughter central capsules and shells by binary fission. These data indicate that in colonial...

  5. Exploring transverse pattern formation in a dual-polarization self-mode-locked monolithic Yb: KGW laser and generating a 25-GHz sub-picosecond vortex beam via gain competition.

    Science.gov (United States)

    Chang, M T; Liang, H C; Su, K W; Chen, Y F

    2016-04-18

    Formation of transverse modes in a dual-polarization self-mode-locked monolithic Yb: KGW laser under high-power pumping is thoroughly explored. It is experimentally observed that the polarization-resolved transverse patterns are considerably affected by the pump location in the transverse plane of the gain medium. In contrast, the longitudinal self-mode-locking is nearly undisturbed by the pump position, even under the high-power pumping. Under central pumping, a vortex beam of the Laguerre-Gaussian LGp,l mode with p = 1 and l = 1 can be efficiently generated through the process of the gain competition with a sub-picosecond pulse train at 25.3 GHz and the output power can be up to 1.45 W at a pump power of 10.0 W. Under off-center pumping, the symmetry breaking causes the transverse patterns to be dominated by the high-order Hermite-Gaussian modes. Numerical analyses are further performed to manifest the symmetry breaking induced by the off-center pumping.

  6. Sparse approaches for the exact distribution of patterns in long multi-states sequences generated by a Markov source

    CERN Document Server

    Nuel, Grégory

    2010-01-01

    We present two novel approaches for the computation of the exact distribution of a pattern in a long sequence. Both approaches take into account the sparse structure of the problem. The first approach relies on a partial recursion computing the largest eigenvalue of the the transition matrix of a Markov chain embedding. The second approach uses fast Taylor expansions of an exact bivariate rational reconstruction of the distribution. We illustrate the interest of both approaches on a simple toy-example and two biological applications: the transcription factors of the Human Chromosome 5 and the PROSITE signatures of functional motifs in proteins. On these examples our methods demonstrate their complementarity and their hability to extend the domain of feasibility for exact computations in pattern problems to a new level.

  7. Effects of Temporal Wind Patterns on the Value of Wind-Generated Electricity in California and the Northwest

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, Ryan H; Wiser, Ryan H; Fripp, Matthias

    2008-05-01

    Wind power production is variable, but also has diurnal and seasonal patterns. These patterns differ between sites, potentially making electric power from some wind sites more valuable for meeting customer loads or selling in wholesale power markets. This paper investigates whether the timing of wind significantly affects the value of electricity from sites in California and the Northwestern United States. We use both measured and modeled wind data and estimate the time-varying value of wind power with both financial and load-based metrics. We find that the potential difference in wholesale market value between better-correlated and poorly correlated wind sites is modest, on the order of 5-10 percent. A load-based metric, power production during the top 10 percent of peak load hours, varies more strongly between sites, suggesting that the capacity value of different wind projects could vary by as much as 50 percent based on the timing of wind alone.

  8. An Impact Velocity Device Design for Blood Spatter Pattern Generation with Considerations for High-Speed Video Analysis.

    Science.gov (United States)

    Stotesbury, Theresa; Illes, Mike; Vreugdenhil, Andrew J

    2016-03-01

    A mechanical device that uses gravitational and spring compression forces to create spatter patterns of known impact velocities is presented and discussed. The custom-made device uses either two or four springs (k1 = 267.8 N/m, k2 = 535.5 N/m) in parallel to create seventeen reproducible impact velocities between 2.1 and 4.0 m/s. The impactor is held at several known spring extensions using an electromagnet. Trigger inputs to the high-speed video camera allow the user to control the magnet's release while capturing video footage simultaneously. A polycarbonate base is used to allow for simultaneous monitoring of the side and bottom views of the impact event. Twenty-four patterns were created across the impact velocity range and analyzed using HemoSpat. Area of origin estimations fell within an acceptable range (ΔXav = -5.5 ± 1.9 cm, ΔYav = -2.6 ± 2.8 cm, ΔZav = +5.5 ± 3.8 cm), supporting distribution analysis for the use in research or bloodstain pattern training. This work provides a framework for those interested in developing a robust impact device.

  9. Impact of Thermal Plumes Generated by Occupant Simulators with Different Complexity of Body Geometry on Airflow Pattern in Rooms

    DEFF Research Database (Denmark)

    Zukowska, Daria; Melikov, Arsen Krikor; Popiolek, Zbigniew

    2008-01-01

    manikins resembling accurately human body shape and then by two heated cylinders. The manikins and the cylinders had the same surface area of 1.63 m2 and the same heat generation of 73 W. CO2 supplied from the top of the heat sources was used for simulating bio-effluents. CO2 concentration was measured...

  10. Academic Generations and Academic Work: Patterns of Attitudes, Behaviors, and Research Productivity of Polish Academics after 1989

    Science.gov (United States)

    Kwiek, Marek

    2015-01-01

    This paper focuses on a generational change taking place in the Polish academic profession: a change in behaviors and attitudes between two groups of academics. One was socialized to academia under the communist regime (1945-1989) and the other entered the profession in the post-1989 transition period. Academics of all age groups are beginning to…

  11. SJL mice infected with Acanthamoeba castellanii develop central nervous system autoimmunity through the generation of cross-reactive T cells for myelin antigens.

    Science.gov (United States)

    Massilamany, Chandirasegaran; Marciano-Cabral, Francine; Rocha-Azevedo, Bruno da; Jamerson, Melissa; Gangaplara, Arunakumar; Steffen, David; Zabad, Rana; Illes, Zsolt; Sobel, Raymond A; Reddy, Jay

    2014-01-01

    We recently reported that Acanthamoeba castellanii (ACA), an opportunistic pathogen of the central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139-151 and myelin basic protein 89-101, and that the epitopes induce experimental autoimmune encephalomyelitis (EAE) in SJL mice reminiscent of the diseases induced with their corresponding cognate peptides. We now demonstrate that mice infected with ACA also show the generation of cross-reactive T cells, predominantly for PLP 139-151, as evaluated by T cell proliferation and IAs/dextramer staining. We verified that PLP 139-151-sensitized lymphocytes generated in infected mice contained a high proportion of T helper 1 cytokine-producing cells, and they can transfer disease to naïve animals. Likewise, the animals first primed with suboptimal dose of PLP 139-151 and later infected with ACA, developed EAE, suggesting that ACA infection can trigger CNS autoimmunity in the presence of preexisting repertoire of autoreactive T cells. Taken together, the data provide novel insights into the pathogenesis of Acanthamoeba infections, and the potential role of infectious agents with mimicry epitopes to self-antigens in the pathogenesis of CNS diseases such as multiple sclerosis.

  12. SJL mice infected with Acanthamoeba castellanii develop central nervous system autoimmunity through the generation of cross-reactive T cells for myelin antigens.

    Directory of Open Access Journals (Sweden)

    Chandirasegaran Massilamany

    Full Text Available We recently reported that Acanthamoeba castellanii (ACA, an opportunistic pathogen of the central nervous system (CNS possesses mimicry epitopes for proteolipid protein (PLP 139-151 and myelin basic protein 89-101, and that the epitopes induce experimental autoimmune encephalomyelitis (EAE in SJL mice reminiscent of the diseases induced with their corresponding cognate peptides. We now demonstrate that mice infected with ACA also show the generation of cross-reactive T cells, predominantly for PLP 139-151, as evaluated by T cell proliferation and IAs/dextramer staining. We verified that PLP 139-151-sensitized lymphocytes generated in infected mice contained a high proportion of T helper 1 cytokine-producing cells, and they can transfer disease to naïve animals. Likewise, the animals first primed with suboptimal dose of PLP 139-151 and later infected with ACA, developed EAE, suggesting that ACA infection can trigger CNS autoimmunity in the presence of preexisting repertoire of autoreactive T cells. Taken together, the data provide novel insights into the pathogenesis of Acanthamoeba infections, and the potential role of infectious agents with mimicry epitopes to self-antigens in the pathogenesis of CNS diseases such as multiple sclerosis.

  13. Dune-scale distribution pattern of herbaceous plants and their relationship with environmental factors in a saline-alkali desert in Central Asia.

    Science.gov (United States)

    Tao, Ye; Wu, Gan-Lin; Zhang, Yuan-Ming

    2017-01-15

    Sand dunes are the main landforms in modern deserts worldwide. As an important type of desert vegetation, herbaceous plants have long been acknowledged for their important ecological functions. We focus on the dune-scale distribution pattern of herbaceous plants and their relationship with the environment. During the early summer of 2010, the herbaceous plant density, coverage, aboveground biomass and eighteen environmental factors were surveyed from 214 plots (5m×5m) across two linear sand dunes (220m×110m) located in the Gurbantunggut Desert, China, a typical saline-alkali desert in Central Asia. Data were analyzed using univariate, ordination, and geostatistical techniques. Three vegetation variables represent a significant clumped distribution (P<0.01) across the entire study site. Obvious differences were observed among different slope positions/transects, with the lowest values observed at the summit. Geostatistics indicated that all of the variables showed a moderate spatial dependence and obvious zonal distribution along the sand dunes. The ranges (lag distance) of density (32.2m) and coverage (33.5m) were close to the average width (31.4m) of the transects. The biomass range (74.1m) was almost equal to the average width (75m) of the sand dunes. Pearson's correlation analysis and nonmetric multidimensional scaling analysis consistently demonstrated that the distributions of herbs on sand dunes were dominantly influenced by sand dune topography (slope position, convexity, and relative height), soil nutrients (total nitrogen and phosphorus) and deep-rooted shrubbery (Ephedra distachya). Compared to large, mobile and steep sand dunes, low, fixed and gentle sand dunes contribute to herbaceous plant abundance and distribution as well as the stability maintenance of the whole desert ecosystem.

  14. Applications of seismic pattern recognition and gravity inversion techniques to obtain enhanced subsurface images of the Earth's crust under the Central Metasedimentary Belt, Grenville Province, Ontario

    Science.gov (United States)

    Roy, Baishali; Mereu, R. F.

    2000-12-01

    Project Lithoprobe's Abitibi-Grenville transect seismic reflection lines 32 and 33 traverse the exposed Central Metasedimentary Belt (CMB) located in the Grenville province of the Precambrian Shield of Canada in southern Ontario. These seismic lines image a zone with a protracted deformational history spanning more than 300Myr. Detailed examination of the commercially processed stacked sections reveals a number of significant deficiencies in some important areas. The image quality in these zones of reduced coherency needs to be enhanced to examine specific features and their relation to the surface geology. Examination of near-vertical seismic data from Lines 32 and 33 revealed that the signal-to-noise ratio was not improved by stacking, due to misalignment of signals even after static, normal moveout corrections and residual static corrections. The presumed reason is that reflected seismic energy following long ray paths in heterogeneous media suffers from relative advances and delays in its propagation, and hence arrives at slightly different times at the receivers, tending to be poorly aligned relative to its theoretical traveltime curves. A pattern recognition (PR) method for signal enhancement followed by energy stacking in moving time windows was used in this study to improve the images in spite of misalignments. Reprocessing has refined the geometry of the reflection profiles. The objective of this paper is to use enhanced images of the seismic reflection data obtained by using a PR approach together with gravity data, using 2.5-D forward and 3-D inversion routines, to give an improved model of subsurface structure in the vicinity of lines 32 and 33. Line 32 is dominated by southeast-dipping reflectors soling into the lower crust. The listric geometry of the strong reflection packages of the CMB boundary thrust zone is interpreted to represent a crustal-scale ramp-flat geometry that accommodated northwest-directed tectonic transport of the CMB. This

  15. Reducing False Alarms of Annual Forecast in the Central China North-South Seismic Belt by Reverse Tracing of Precursors (RTP) Using the Pattern Informatics (PI) `Hotspots'

    Science.gov (United States)

    Zhang, Shengfeng; Wu, Zhongliang; Jiang, Changsheng

    2016-05-01

    The annual consultation on the likelihood of earthquakes in the next year, the `Annual Consultation Meeting', has been one of the most important forward forecast experiments organized by the China Earthquake Administration (CEA) since the 1970s, in which annual alarm regions are identified by an expert panel considering multi-disciplinary `anomalies'. In such annual forecasts, one of the problems in need of further technical solution is its false alarms. To tackle this problem, the concept of `reverse tracing of precursors (RTP)' is used to the annual consultation, as a temporal continuation and spatial extension of the work of Zuc(hao) et al. (Pure Appl Geophys 167:783-800, 2010). The central China north-south seismic belt (in connection to the CSEP testing region) is selected as the testing region of such an approach. Applying the concept of RTP, for an annual alarm region delineated by the Annual Consultation Meeting, the distribution of `hotspots' of the pattern informatics (PI), which targets the 5-year-scale seismic hazard, is considered. The `hit', or successful forecast, of the annual seismic hazard is shown to be related to the sufficient coverage of the `hotspots' within the annual alarm region. The ratio of the areas of the `hotspots' over the whole area of the annual alarm region is thus used to identify the false alarms which have few `hotspots'. The results of the years 2004-2012 show that using a threshold of 17 % can reduce 34 % (13 among 38) of the false alarms without losing the successful hit (being 6 in that period).

  16. Traditional Homegardens and Domestic Biomass Fuel Consumption Pattern in the Developing World: The Case of a South-Central Rural Village of Bangladesh

    Energy Technology Data Exchange (ETDEWEB)

    Mukul, S.A. (Dept. of Forestry and Environmental Science, School of Agriculture and Mineral sciences, Shahjalal Univ. of Science and Technology, Sylhet 3114 (Bangladesh)). E-mail: sharif_a_mukul@yahoo.com

    2008-10-15

    Peoples living in most developing countries meet majority of their biomass fuel requirements from the forest. However, this usual practice becomes difficult to maintain as the forest of this region decreases in an alarming rate. In such context, homegardens will have to play the key role in near future where in many forest poor regions it's already playing the vital role. An exploratory study was conducted in a south-central rural village of Bangladesh to realize this potential contribution of homegardens to households domestic biomass fuel supplies, which is as well a virtually forest poor region of the country. Households were grouped into three different land holding categories and a total of thirty respondents, 10 from each category were selected randomly to understand their domestic biomass fuel consumption pattern as well as the role of homegardens to meet this fuel supply. Study suggested that, majority (87%) of the households of the area rely extensively on their homegardens to meet their domestic cooking energy requirements. During the study 47 homestead species were identified having fuel value of which 12 were identified as the most preferred species in the area. The contribution of wood fuel in households domestic energy sharing was reported as 56% followed by dried leaves (21%), dung cake/sticks (14%), crop residues (6%) and others (3%). Study finally concluded for a rich homegarden system in forest near regions to conserve country's remaining forest by providing an alternative source of biomass fuel. A participatory management of governments' fallow and khas lands, public places including road, railway and canal banks for tree farming to benefit rural land-less and marginal people were also recommended

  17. A prospective study of magnetic resonance imaging patterns of central nervous system infections in pediatric age group and young adults and their clinico-biochemical correlation

    Directory of Open Access Journals (Sweden)

    Kamini Gupta

    2016-01-01

    Full Text Available Background: Infections of the central nervous system (CNS are common and routinely encountered. Our aim was to evaluate the neuroimaging features of the various infections of the CNS so as to differentiate them from tumoral, vascular, and other entities that warrant a different line of therapy. Aims: Our aim was to analyze the biochemical and magnetic resonance imaging (MRI features in CNS infections. Settings and Design: This was a longitudinal, prospective study over a period of 1½ years. Subjects and Methods: We studied cerebrospinal fluid (CSF findings and MRI patterns in 27 patients of 0–20 years age group with clinical features of CNS infections. MRI was performed on MAGNETOM Avanto 18 Channel 1.5 Tesla MR machine by Siemens India Ltd. The MRI protocol consisted of diffusion-weighted and apparent diffusion coefficient imaging, turbo spin echo T2-weighted, spin echo T1-weighted, fluid-attenuated inversion recovery (FLAIR, and gradient-echo in axial, FLAIR in coronal, and T2-weighted in sagittal plane. Contrast-enhanced T1-weighted sequence and MR spectroscopy were done whenever indicated. Results and Conclusions: We found that most of the children belong to 1–10 years age group. Fungal infections were uncommon, mean CSF adenosine deaminase values specific for tuberculosis and mean CSF glucose-lowered in pyogenic. Hemorrhagic involvement of thalamus with/without basal ganglia and brainstem involvement may indicate Japanese encephalitis or dengue encephalitis. Diffusion restriction or hemorrhage in not expected in the brainstem afflicted lesions of rabies. Congenital cytomegalovirus can cause cortical malformations. T1 hyperintensities with diffusion restriction may represent viral encephalitis. Lesions of acute disseminated encephalomyelitis (ADEM may mimic viral encephalitis. Leptomeningeal enhancement is predominant in pyogenic meningitis. Basilar meningitis in the presence of tuberculomas is highly sensitive and specific for

  18. Conventional and intelligent generalized supervisory control for combined cycle generating power stations.; Control supervisiorio generalizado convencional e inteligente para centrales de generacion de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Martinez M, Miguel A; Sanchez P, Marino [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Gonzalez Rubio S, Jose L [Cento Nacional de Investigacion y Desarrollo Tecnologico (Cenidet), Cuernavaca, Morelos (Mexico)

    2005-07-01

    Under the expectations of expansion of electric power generation in Mexico, this work exposes the development of a conventional and intelligent generalized supervisory control (CSG) for a combined cycle generation power plant. This one allows to obtain the optimal operation of the power plant through the automatic starting of the generating units and to obtain the maximum possible amount of electrical power in automatic and safe form. For the development of the CSG a control loop by temperature was implemented for the gas turbine system and a control loop by strangled pressure for the gas turbine and a control loop by strangled pressure for the steam turbine. The design of these supervisory systems was made with base in the critical limits on the involved variables of the process: blading average temperature, for the gas turbine (GT) and strangled pressure for the steam turbine (ST) [Spanish] Bajo estas expectativas de expansion de generacion de energia en Mexico, este trabajo expone el desarrollo de un control supervisorio generalizado (CSG) para una central generacion de ciclo combinado. Este permite lograr la operacion optima de la planta a traves del arranque automatico de las unidades generadoras y obtener la maxima cantidad posible de potencia electrica en forma automatica y segura. Para el desarrollo del CSG se implanto un lazo de control por temperatura para el sistema de turbina de gas y un lazo de control por presion estrangulada para la turbina de gas y un lazo de control por presion estrangulada para la turbina de vapor. El diseno de estos sistemas supervisorio se realizo con base en los limites criticos de las variables del proceso involucradas: temperatura promedio de empaletado para la turbina de gas (TG) y presion estrangulada para la turbina de vapor (TV)

  19. Soil cover patterns influence on the land environmental functions, agroecological quality, land-use and monitoring efficiency in the Central Russia

    Science.gov (United States)

    Vasenev, Ivan; Yashin, Ivan; Lukin, Sergey; Valentini, Riccardo

    2015-04-01

    First decades of XXI century actualized for soil researches the principal methodical problem of most modern geosciences: what spatial and temporal scale would be optimal for land quality evaluation and land-use practice optimizing? It is becoming obvious that this question cannot have one solution and have to be solved with especial attention on the features of concrete region and landscape, land-use history and practical issues, land current state and environmental functions, soil cover patterns and variability, governmental requirements and local society needs, best available technologies and their potential profitability. Central Russia is one of the most dynamical economic regions with naturally high and man-made complicated landscape and soil cover variability, long-term land-use history and self-contradictory issues, high potential of profitable farming and increased risks of land degradation. Global climate and technological changes essentially complicate the originally high and sharply increased in XX century farming land heterogeneity in the Central Russia that actualizes system analysis of its zonal, intra-zonal and azonal soil cover patterns according to their influence on land environmental functions, agroecological quality, and land-use and monitoring efficiency variability. Developed by the Laboratory of agroecological monitoring, ecosystem modeling & prediction (LAMP / RTSAU with support of RF Governmental projects #11.G34.31.0079 and #14.120.14.4266) regional systems of greenhouse gases environmental monitoring RusFluxNet (6 fixed & 1 mobile eddy covariance stations with zonal functional sets of key plots with chamber investigations in 5 Russian regions) and of agroecological monitoring (in representative key plots with different farming practice in 9 RF regions) allow to do this analysis in frame of enough representative regional multi-factorial matrix of soil cover patterns, bioclimatic conditions, landscape features, and land-use history and

  20. Generalized conventional and intelligent supervisory control system for combined cycle generation power plants; Sistema de control supervisorio generalizado convencional e inteligente para centrales de generacion de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Morales, Miguel Angel

    2004-12-15

    (conventional or intelligent) is possible to get more power generation than if we use the automatic methods based on feedback MW control. Consequently, the financial benefit due to the MW generated along a period of 2 months, is equivalent to return the investment required if the CCPP would had been repowered. Test also showed that with the fuzzy based SGC is possible to get a 'little more' power generation than if we use the PID based SGC. The development and implementation of the SGC was made in three phases: First Phase: Upgrading of the simulation dynamic mathematical model and implementation in a new software platform based on LabWindows/CVI. Second Phase: Design, implementation and testing of the PID based SGC. Third Phase: Design and implementation and testing of the Intelligent SGC, based in fuzzy logic. [Spanish] El programa de obras de generacion de la Comision Federal de Electricidad (CFE) del ano 2004 al ano 2008 esta caracterizado por el dominio del proceso de ciclo combinado para la expansion de generacion de energia en Mexico [CFE, 2000]. De acuerdo con los datos presentados por esta fuente, el incremento estimado en la capacidad de generacion de potencia electrica es de 12876 MW, de los cuales las centrales de ciclo combinado aportaran 10655 MW, lo que representa el 82.75%. Bajo estas expectativas de expansion de generacion de energia en Mexico, en este trabajo de tesis se desarrollo un sistema de control supervisorio generalizado (CSG) convencional (PID) e inteligente (logica difusa) para una central de generacion de ciclo combinado, el cual permite lograr la operacion optima de la planta a traves del arranque automatico de las unidades generadoras y obtener la maxima cantidad posible de potencia electrica en forma automatica y segura. Para el desarrollo del CSG se implanto un lazo de control por temperatura para el sistema de turbina de gas (TG) y un lazo de control por presion estrangulada para la turbina de vapor (TV). El diseno de estos sistemas

  1. Generation and fate of glacial sediments in the central Transantarctic Mountains based on radiogenic isotopes and implications for reconstructing past ice dynamics

    Science.gov (United States)

    Farmer, G. Lang; Licht, Kathy J.

    2016-10-01

    The Nd, Sr and Pb isotopic compositions of glacial tills from the Byrd and Nimrod Glaciers in the central Transantarctic Mountains (TAM) in East Antarctica were obtained to assess the sources of detritus transported by these ice masses. Tills from lateral moraines along the entire extent of both glaciers have isotopic compositions consistent with their derivation predominately from erosion of adjacent bedrock. Fine- (<63μ) and coarser-grained (0.5 mm-2 mm) sediment from these tills have identical isotopic characteristics, indicating that fine-grained detritus is the product of further comminution of coarser sediments. Comparison of present-day till isotopic data to existing data from fine-grained LGM tills in the central Ross Sea confirm that these were deposited from East Antarctic ice that expanded through the TAM and indicates that the LGM sediments are mixtures of detritus eroded along the entire path of ice transiting the TAM. If specific lithologies were preferentially eroded as ice passed through the TAM, it is not clearly evident in the Ross Sea till isotopic compositions. Our data do demonstrate, however, that glacial tills generated from erosion of inboard regions of the mountain belt yield sediment with a larger component of 560 Ma to 600 Ma detrital zircons and lower average εNd(0) values (<-5) than that produced further downstream. As a result, past retreat of ice grounding-lines up the narrow valleys of the TAM resulting in active erosion of inboard region should recognizable in glacial sediments deposited in the Ross Sea and so provide a means to identify times when the East Antarctic ice sheet was smaller than today. This study highlights both the value and necessity of utilizing multiple provenance methods in evaluating glacial erosion and transport when reconstructing past ice sheet dynamics.

  2. Neutrophil Extracellular Traps Identification in Tegumentary Lesions of Patients with Paracoccidioidomycosis and Different Patterns of NETs Generation In Vitro.

    Directory of Open Access Journals (Sweden)

    Amanda Manoel Della Coletta

    Full Text Available Paracoccidioidomycosis (PCM is a systemic mycosis, endemic in most Latin American countries, especially in Brazil. It is caused by the thermo-dimorphic fungus of the genus Paracoccidioides (Paracoccidioides brasiliensis and Paracoccidioides lutzii. Innate immune response plays a crucial role in host defense against fungal infections, and neutrophils (PMNs are able to combat microorganisms with three different mechanisms: phagocytosis, secretion of granular proteins, which have antimicrobial properties, and the most recent described mechanism called NETosis. This new process is characterized by the release of net-like structures called Neutrophil Extracellular Traps (NETs, which is composed of nuclear (decondensed DNA and histones and granular material such as elastase. Several microorganisms have the ability of inducing NETs formation, including gram-positive and gram-negative bacteria, viruses and some fungi. We proposed to identify NETs in tegumentary lesions of patients with PCM and to analyze the interaction between two strains of P. brasiliensis and human PMNs by NETs formation in vitro. In this context, the presence of NETs in vivo was evidenced in tegumentary lesions of patients with PCM by confocal spectrum analyzer. Furthermore, we showed that the high virulent P. brasiliensis strain 18 (Pb18 and the lower virulent strain Pb265 are able to induce different patterns of NETs formation in vitro. The quantification of extracellular DNA corroborates the idea of the ability of P. brasiliensis in inducing NETs release. In conclusion, our data show for the first time the identification of NETs in lesions of patients with PCM and demonstrate distinct patterns of NETs in cultures challenged with fungi in vitro. The presence of NETs components both in vivo and in vitro open new possibilities for the detailed investigation of immunity in PCM.

  3. Effect of the electric field pattern on the generation of fast electrons in front of lower hybrid launchers

    Energy Technology Data Exchange (ETDEWEB)

    Valade, Laurent, E-mail: laurent.valade@cea.fr; Ekedahl, Annika; Colas, Laurent; Goniche, Marc; Hillairet, Julien [CEA, IRFM, F-13108 Saint Paul-lez-Durance (France); Fuchs, Vladimir; Petrzilka, Vaclav [Institute of Plasma Physics, AS CR, Prague (Czech Republic); Li, Miaohui; Zhang, Bin [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2015-12-10

    The effect of the detailed waveguide spectrum on the electron acceleration has been studied for the 3.7 GHz LHCD launchers in Tore Supra, i.e. the ITER-like passive-active multijunction (PAM) launcher and the fully-active-multijunction (FAM) launcher, using test electron modelling technique. The detailed launched antenna wave spectrum is used as input to the code that computes the dynamics of the electrons in the electric field. Comparison with the LHCD launchers in EAST, operating at 2.45 GHz and 4.6 GHz, has also been made. The simulations show that the PAM-design generates lower flux of fast electrons than FAM-launchers, this could be the consequence of the wider waveguide of PAM-launcher (14.65 mm for Tore-Supra) than FAM-launcher (8 mm for Tore-Supra)

  4. Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries

    Science.gov (United States)

    Larrañaga, Nerea; Sanchez, Mª José; Ardanaz, Eva; Felipe, Saray; Marcos-Gragera, Rafael; Ramos, María; Carulla, Marià; Chirlaque, Mª Dolores; Argüelles, Marcial V.; Martos, Carmen; Mateo, Antonio; Peris-Bonet, Rafael

    2016-01-01

    Objective: To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain. Methods: Cases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for the period 1983-2007 and trends were evaluated using Joinpoint regression analysis. Results: The studied tumour groups accounted for 36% of total childhood cancers and 47.6% of those diagnosed in adolescence with annual rates per million of 53.5 and 89.3 respectively. In children 0 to 14 years of age, Neuroblastoma (NB) was the commonest (7.8%) followed by Soft-tissue sarcomas (STS) (6.3%), bone tumours (BT) (6.2%) and renal tumours (RT) (4.5%). NB was the most frequently diagnosed tumour before the 5th birthday, while STS and BT were the commonest at 5-9 years of age, and BT and Carcinoma and other epithelial tumours (COET) at 10-14. COET presented the highest incidence in adolescents, followed by germ-cell tumours (GCT), BT and STS. These four diagnostic groups accounted for 94% of total non-CNS solid tumours, in adolescents. Overall incidence rates increased significantly in children up to 1996 with an annual percentage change (APC) of 2.6% (95%CI: 1.7; 3.6). NB and COET showed significant time trend (APCs: 1.4% and 3.8% respectively) while other tumour groups such as RT, STS, BT or GCT had no significant changes over time. A significant increase was present in NB under the age of 5 and in BT and STS in children aged 10-14 years. In adolescents there were significant increases for all tumours combined (APC=2.7; 95%CI: 1.8-3.6) and for STS, GCT and COET (APCs: 3.2%, 4.4% and 3.5% respectively), while other tumour groups such as hepatic tumours, BT or thyroid carcinomas showed a decreasing trend or no increase. Conclusions: Overall, the incidence of the studied cancers in children increased along the period 1983-1996 with no posterior significant rise, while the incidence

  5. Sequencing of Local Therapy Affects the Pattern of Treatment Failure and Survival in Children With Atypical Teratoid Rhabdoid Tumors of the Central Nervous System

    Energy Technology Data Exchange (ETDEWEB)

    Pai Panandiker, Atmaram S., E-mail: atmaram.pai-panandiker@stjude.org [Department of Radiological Sciences, St. Jude Children' s Research Hospital, Memphis, TN (United States); Merchant, Thomas E.; Beltran, Chris [Department of Radiological Sciences, St. Jude Children' s Research Hospital, Memphis, TN (United States); Wu, Shengjie [Department of Biostatistics, St. Jude Children' s Research Hospital, Memphis, TN (United States); Sharma, Shelly [Department of Radiological Sciences, St. Jude Children' s Research Hospital, Memphis, TN (United States); Boop, Frederick A. [Department of Surgery, St. Jude Children' s Research Hospital, Memphis, TN (United States); Jenkins, Jesse J. [Department of Pathology, St. Jude Children' s Research Hospital, Memphis, TN (United States); Helton, Kathleen J. [Department of Radiological Sciences, St. Jude Children' s Research Hospital, Memphis, TN (United States); Wright, Karen D.; Broniscer, Alberto [Department of Oncology, St. Jude Children' s Research Hospital, Memphis, TN (United States); Kun, Larry E. [Department of Radiological Sciences, St. Jude Children' s Research Hospital, Memphis, TN (United States); Gajjar, Amar [Department of Oncology, St. Jude Children' s Research Hospital, Memphis, TN (United States)

    2012-04-01

    Purpose: To assess the pattern of treatment failure associated with current therapeutic paradigms for childhood atypical teratoid rhabdoid tumors (AT/RT). Methods and Materials: Pediatric patients with AT/RT of the central nervous system treated at our institution between 1987 and 2007 were retrospectively evaluated. Overall survival (OS), progression-free survival, and cumulative incidence of local failure were correlated with age, sex, tumor location, extent of disease, and extent of surgical resection. Radiotherapy (RT) sequencing, chemotherapy, dose, timing, and volume administered after resection were also evaluated. Results: Thirty-one patients at a median age of 2.3 years at diagnosis (range, 0.45-16.87 years) were enrolled into protocols that included risk- and age-stratified RT. Craniospinal irradiation with focal tumor bed boost (median dose, 54 Gy) was administered to 18 patients. Gross total resection was achieved in 16. Ten patients presented with metastases at diagnosis. RT was delayed more than 3 months in 20 patients and between 1 and 3 months in 4; 7 patients received immediate postoperative irradiation preceding high-dose alkylator-based chemotherapy. At a median follow-up of 48 months, the cumulative incidence of local treatment failure was 37.5% {+-} 9%; progression-free surviva