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Sample records for central european vaccination

  1. Central European Vaccination Advisory Group (CEVAG) guidance statement on recommendations for influenza vaccination in children

    Science.gov (United States)

    2010-01-01

    Background Influenza vaccination in infants and children with existing health complications is current practice in many countries, but healthy children are also susceptible to influenza, sometimes with complications. The under-recognised burden of disease in young children is greater than in elderly populations and the number of paediatric influenza cases reported does not reflect the actual frequency of influenza. Discussion Vaccination of healthy children is not widespread in Europe despite clear demonstration of the benefits of vaccination in reducing the large health and economic burden of influenza. Universal vaccination of infants and children also provides indirect protection in other high-risk groups in the community. This paper contains the Central European Vaccination Advisory Group (CEVAG) guidance statement on recommendations for the vaccination of infants and children against influenza. The aim of CEVAG is to encourage the efficient and safe use of vaccines to prevent and control infectious diseases. Summary CEVAG recommends the introduction of universal influenza vaccination for all children from the age of 6 months. Special attention is needed for children up to 60 months of age as they are at greatest risk. Individual countries should decide on how best to implement this recommendation based on their circumstances. PMID:20546586

  2. European Vaccine Initiative: lessons from developing malaria vaccines.

    Science.gov (United States)

    Geels, Mark J; Imoukhuede, Egeruan B; Imbault, Nathalie; van Schooten, Harry; McWade, Terry; Troye-Blomberg, Marita; Dobbelaer, Roland; Craig, Alister G; Leroy, Odile

    2011-12-01

    For over 10 years, the European Vaccine Initiative (EVI; European Malaria Vaccine Initiative until 2009) has contributed to the development of 24 malaria candidate vaccine antigens with 13 vaccine candidates being advanced into Phase I clinical trials, two of which have been transitioned for further clinical development in sub-Saharan Africa. Since its inception the EVI organization has operated as a funding agency, but with a clear service-oriented strategy. The scientific successes and difficulties encountered during these years and how these efforts have led to standardization and harmonization in vaccine development through large-scale European consortia are discussed. In the future, the EVI will remain instrumental in the pharmaceutical and clinical development of vaccines against 'diseases of poverty' with a continued focus on malaria. EVI will continue to focus on funding and managing preclinical evaluation up to Phase I/II clinical trials and strengthening the vaccine-development infrastructure in Europe, albeit with a global orientation.

  3. Can the European Central Bank Create a European identity?

    DEFF Research Database (Denmark)

    Ravn Sørensen, Anders

    2014-01-01

    In what ways do central banks construct community, and how may the European Central Bank (ECB) contribute to a supranational European identity? In this paper I seek to answer these two questions by developing a conceptual framework for the ways that central banks construct national identities and...

  4. Independent and Accountable Central Banks and the European Central Bank

    Directory of Open Access Journals (Sweden)

    Pedro A. B. de Sousa

    2001-07-01

    Full Text Available This paper begins with the concept of central bank independence and focuses its argument around one of its major drawbacks the potential absence of accountability by the monetary authority. Then, beyond defining an alternative legal central bank independence index, we analyse the current Statutes of thirty-two central banks, and we quantify their legal independence and accountability degrees. With that data, we confirm previous studies, showing evidence of a de jure negative relationship between central bank independence and democratic accountability, though not as strong as it is usually argued. Still, we remain aware that some very independent central banks are also very low accountable the European Central Bank (ECB is a good example. Finally, we discuss the advantages and disadvantages of a contract à la Walsh between the ECB and a European Community organ, and we ask for a more in-depth analysis and understanding of these subjects, in order to improve the EMU institutional picture.

  5. The cost of vaccination throughout life: A western European overview.

    Science.gov (United States)

    Ethgen, Olivier; Cornier, Murielle; Chriv, Emilie; Baron-Papillon, Florence

    2016-08-02

    Despite the interest of policy makers, the actual investment in vaccination is poorly documented. Our study assessed the costs of vaccination throughout life for a fully immunized Western European citizen. National vaccination calendars for England, France, Germany, Italy, Portugal, Spain and Sweden were retrieved. We differentiated men from women and healthy individuals from those suffering from underlying conditions who require specific additional vaccinations. Vaccine costs and administration fees were retrieved from official national source and calculated from the national healthcare perspective. Vaccinating an individual against up to 17 diseases throughout his entire life and in full compliance with national vaccination calendars cost between €328 and €2,352 (vaccines costs only) and between €443 and €3,395 (administration costs included), the lowest range corresponds to a healthy man in Sweden and the highest to a woman with underlying conditions in England. Vaccination costs varied among countries due to heterogeneous national vaccination calendars and organization. In all countries, adults (18-64 y) and elderly (≥65 y) accounted for the lowest vaccines costs compared with infants (0-24 m) and children/adolescents (2-17 y). In comparison, other mass secondary preventive therapies may be at least 3 times more costly. Vaccination requires a relatively low level of investment per individual. Our estimates should be considered to be the maximum potential costs due to our 100% compliance assumption. Increasing coverage rates would bring additional public health benefits for a relatively low incremental cost. A life-course approach of vaccination should also be encouraged because some missed opportunities remain in senior vaccinations.

  6. Vaccine-induced canine distemper in European mink, Mustela lutreola.

    Science.gov (United States)

    Sutherland-Smith, M R; Rideout, B A; Mikolon, A B; Appel, M J; Morris, P J; Shima, A L; Janssen, D J

    1997-09-01

    This report describes vaccine-induced canine distemper virus (CDV) infection in four European mink (Mustela lutreola) induced by the administration of a multivalent, avian-origin vaccine. Clinical signs consisting of seizures, ataxia, facial twitching, oculonasal discharge, hyperkeratosis of footpads, and anorexia developed 16-20 days postvaccination. Conjunctival smears from one animal were positive for CDV antigen by direct fluorescent antibody testing, confirming the clinical diagnosis. The four mink died 16-26 days postvaccination. Gross and microscopic lesions that were diagnostic for CDV infection included interstitial pneumonia, lymphoid depletion, nonsuppurative encephalitis, and dermatitis. Vaccine-strain virus was isolated from tissues of three animals. Cases of vaccine-induced distemper in mustelids using avian-origin vaccine have seldom been reported.

  7. Performance evaluation of Central European companies

    Directory of Open Access Journals (Sweden)

    Petr Fiala

    2015-10-01

    Full Text Available The paper presents a modelling approach for performance comparison of Central European companies on three levels: country, industry, and company. The approach is based on Data Envelopment Analysis and Analytic Hierarchy Process. The proposed model consists of two basic sections. The first section estimates the importance of selected industries in the countries, whereas the second section evaluates the performance of companies within industries. The results of both sections are synthesized and finally the country performance is estimated. The evaluation is based on the data set resulting from a survey of companies from selected industries.

  8. Regulatory Regionalism and Education: The European Union in Central Asia

    Science.gov (United States)

    Jones, Peter

    2010-01-01

    This paper investigates the purchase which Jayasuriya's regulatory regionalism approach offers for an analysis of the European Union's engagement in Central Asia. The European Union has a clearly articulated strategy through which to pursue what it sees as its interests in Central Asia and the development of a range of EU-Central Asia education…

  9. Greenhouse gas fluxes over Central European grasslands

    Science.gov (United States)

    Hörtnagl, L. J.; Bahn, M.; Barthel, M.; Eugster, W.; Klumpp, K.; Ladreiter-Knauss, T.; Merbold, L.; Wohlfahrt, G.; Buchmann, N. C.

    2014-12-01

    The uptake of carbon dioxide (CO2) by grassland ecosystems can be offset by the concurrent emission of the greenhouse gases methane (CH4) and nitrous oxide (N2O) in terms of CO2-equivalents. As a consequence, CH4 and N2O emissions can contribute to an increase of the global warming potential (GWP) of the respective study site. For a full assessment of the climatic impact of grassland ecosystems it is therefore necessary to quantify fluxes of these two compounds in combination with CO2 exchange. Since agricultural management practices and land use change at a given site can have a strong impact on annual CH4 and N2O budgets, both compounds are a frequent topic of discussion when planning GHG mitigation strategies.Here we present an overview of the GHG exchange of eight managed Central European grassland sites along a gradient of elevation and land use intensity. Fluxes of the three major GHGs CO2, CH4 and N2O were quantified using the eddy covariance or chamber technique. The grasslands differed with regard to the amount of fertilizer input, frequency of cuts and grazing duration and intensity, ranging from more intensively managed to very lightly managed and abandoned grassland. In this presentation we focus on time periods when measurements of all three compounds were available for all sites. We investigate common features among observed CH4 and N2O exchange patterns at the different grassland sites in relation to management activities and concurrently measured biotic / abiotic parameters. In addition, we evaluate the impact of CH4 and N2O fluxes on the annual GWP of field sites for which long-term measurements are available.

  10. Establishing credibility: Evolving perceptions of the European Central Bank

    OpenAIRE

    Linda S. Goldberg; Klein, Michael W

    2005-01-01

    The credibility of a central bank’s anti-inflation stance, a key determinant of its success, may reflect institutional structure or, more dynamically, the history of policy decisions. The first years of the European Central Bank (ECB) provide a natural experiment for considering whether, and how, central bank credibility evolves. In this paper, we present a model demonstrating how the high-frequency response of asset prices to news reflects market perceptions of the anti-inflation stance of a...

  11. EU Energy Policy and Future European Energy Markets: Consequences for the Central and East European States

    OpenAIRE

    Margarita M. Balmaceda

    2002-01-01

    This working paper explores the European Union vector in the Central and East European (CEE) energy situation, in particular in terms of the CEE countries' energy relationship with Russia. Attention is paid not only to concrete EU energy policies but also to the larger question of European energy markets. EU policies impact the CEE states' energy relationship with Russia through specific EU requirements vis-à-vis the candidate countries, through the side-effects of other EU policies, through ...

  12. Pandemic influenza A(H1N1) 2009 vaccines in the European Union.

    Science.gov (United States)

    Johansen, K; Nicoll, A; Ciancio, B C; Kramarz, P

    2009-10-15

    Pandemic vaccines from four manufacturers are now available for use within the European Union (EU). Use of these vaccines will protect individuals and reduce the impact on health services to more manageable levels. The majority of the severely ill will be from known risk groups and the best strategy will be to start vaccinating in line with the recommendation from the European Union Health Security Committee prioritizing adults and children with chronic conditions, pregnant women and healthcare workers. The composition of authorized vaccines is reviewed in this article. The vaccine strain in all authorized pandemic vaccines worldwide is based on the same initial isolate of influenza A/California/7/2009 (H1N1)v but the vaccines differ in conditions for virus propagation, antigen preparation, antigen content and whether they are adjuvanted or not. The vaccines are likely to be effective since no significant genetic or antigenic drift has occurred and there are already mechanisms for estimating clinical effectiveness. Influenza vaccines have good safety records and no safety concerns have so far been encountered with any of the vaccines developed. However, special mechanisms have been devised for the early detection and rigorous investigation of possible significant side effects in Europe through post-marketing surveillance and analysis. Delivery of the vaccines to the risk groups will pose difficulties where those with chronic illnesses are not readily identifiable to the healthcare services. There is considerable scope for European added value through Member States with excess vaccines making them available to other states.

  13. THE EUROPEAN CENTRAL BANK AND THE EUROZONE CRISIS MANAGEMENT

    Directory of Open Access Journals (Sweden)

    MONICA ŞAGUNA

    2013-05-01

    Full Text Available The Euro is the single currency shared by 17 of the European Union's Member States, which together make up the Euro area. Since its introduction, in January 2002, it became the second most traded currency in the world after the United States dollar. With the launch of the Euro, the monetary policy became the responsibility of the independent European Central Bank, which was created for that purpose, and of the national central banks of the Member States, having adopted the Euro. However, the accumulation of massive and unsustainable deficits and public debt levels in a number of peripheral economies threatened the Eurozone's viability by the end of its first decade, triggering a Eurozone sovereign debt crisis. The institutional mechanisms surrounding the Euro have also been an integral part of the crisis. On this line, the European Monetary Union is supported on one side by treaties and multilateral agreements including the Maastricht Treaty, the Stability and Growth Pact and the Lisbon Strategy and, on the other side, by the European Central Bank. The combination of these institutions has produced a mix of monetary, fiscal and labour market policies with powerful social implications. And, what started as a debt crisis in Greece in late 2009 has evolved into a broader economic and political crisis in the Eurozone and European Union. In this framework, the purpose of my paper is to analyze the roots of the Eurozone crisis, as the biggest challenge since the Euro adoption and the European Central Bank’s response to it. Therefore the objectives are: identification of the reasons that stand behind the crisis, then observing how the crisis has affected the functioning of the European Central Bank and the Euro, and how it was forced to respond and, finally, focusing on the future and the challenges that lie ahead.

  14. Influenza Vaccine Research funded by the European Commission FP7-Health-2013-Innovation-1 project.

    Science.gov (United States)

    Liu, Heng; Frijlink, Henderik W; Huckriede, Anke; van Doorn, Eva; Schmidt, Ed; Leroy, Odile; Rimmelzwaan, Guus; McCullough, Keneth; Whelan, Mike; Hak, Eelko

    2016-11-21

    Due to influenza viruses continuously displaying antigenic variation, current seasonal influenza vaccines must be updated annually to include the latest predicted strains. Despite all the efforts put into vaccine strain selection, vaccine production, testing, and administration, the protective efficacy of seasonal influenza vaccines is greatly reduced when predicted vaccine strains antigenically mismatch with the actual circulating strains. Moreover, preparing for a pandemic outbreak is a challenge, because it is unpredictable which strain will cause the next pandemic. The European Commission has funded five consortia on influenza vaccine development under the Seventh Framework Programme for Research and Technological Development (FP7) in 2013. The call of the EU aimed at developing broadly protective influenza vaccines. Here we review the scientific strategies used by the different consortia with respect to antigen selection, vaccine delivery system, and formulation. The issues related to the development of novel influenza vaccines are discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. TEACHING ENGLISH IN SEVERAL CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Sim Monica Ariana

    2008-05-01

    Full Text Available The Central and Eastern European countries find themselves at present, following a period of transition in all domains, education included. One of the greatest challenges is providing sufficient foreign language education so as to meet the growing demand especially after along period of time when foreign languages were seriously and damagingly neglected. This paper is an attempt to briefly present the way English language is taught in several Central and Eastern European Countries as well as to underline the importance of this educational process and maybe to offer some applicable solutions to teaching English in Romania

  16. HLA genes in the Chuvashian population from European Russia: admixture of Central European and Mediterranean populations.

    Science.gov (United States)

    Arnaiz-Villena, Antonio; Martinez-Laso, Jorge; Moscoso, Juan; Livshits, Gregory; Zamora, Jorge; Gomez-Casado, Eduardo; Silvera-Redondo, Carlos; Melvin, Kristin; Crawford, Michael H

    2003-06-01

    HLA alleles have been determined for the first time in individuals from the Chuvashian population by DNA typing and sequencing. HLA-A, -B, -DR, and -DQ allele frequencies and extended haplotypes have also been determined, and the results compared to those for Central Europeans, Siberians and other Asians, Caucasians, Middle Easterners, and Mediterranean peoples. Genetic distances, neighbor-joining dendrograms, and correspondence analysis have been performed. Present-day Chuvash speak an Altaic-Turkic language and are genetically related to Caucasians (Georgians), Mediterraneans, and Middle Easterners, and not only to Central or Northern Europeans; Chuvash contain little indications of Central Asian-Altaic gene flow. Thus, present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people.

  17. Double Taxation Conventions in Central and Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Dumiter Florin

    2016-12-01

    Full Text Available In this article we provide a qualitative overview regarding the panacea of double taxation conventions in Central and Eastern European Countries. Double taxation paradigm highlights some serious problems arising from multiple taxation of the same income or capital. In the European Union these problems suggest that there is a strong need of a “best practice” construction of an optimal fiscal space in order to eliminate or reduce this problem. Central and Eastern European Countries have some special features: on one hand these countries have been influenced by the communist and postcommunism era, and on the other hand there are specific particularities for each country which must be economically and judicially understood and explained. This article highlights the structure, construction and appliance of the double taxation conventions in the Central and Eastern European Countries. The conclusions of this article enact the solutions of the potential problems of double taxation, especially in these former communist countries, with respect to the strengthening of the new fiscal space in the European Union.

  18. An editorial perspective on Barbieri and Capri article: Is vaccination good value for money? A review of cost-utility analyses of vaccination strategies in eight European countries

    Directory of Open Access Journals (Sweden)

    Mondher Toumi

    2016-12-01

    Full Text Available An editorial perspective on Barbieri and Capri article: Is vaccination good value for money? A review of cost-utility analyses of vaccination strategies in eight European countries

  19. The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines

    NARCIS (Netherlands)

    Chapman, Martin D.; Ferreira, Fatima; Villalba, Mayte; Cromwell, Oliver; Bryan, Donna; Becker, Wolf-Meinhard; Fernández-Rivas, Montserrat; Durham, Stephen; Vieths, Stefan; van Ree, Ronald; Aalbers, M.; Notten, S.; Ooievaar-de Heer, P.; Ferreira, F.; Gademaier, G.; Wallner, M.; Villalba, M.; Rodriguez, R.; Becker, W.-M.; Eberhardt, F.; Lepp, U.; Raulf-Heimsoth, M.; Valenta, R.; Focke, M.; Bryan, D.; Dolman, C.; Das, R. G.; Vieths, S.; Fötisch, K.; Di Felice, G.; Pini, C.; Cromwell, O.; Fiebig, H.; Weber, B.; van Schijndel, H.; Dorpema, J. W.; Marco, F. M.; Monsalve, R.; Barber, D.; Caldas, E. Fernandez; Moingeon, P.; Didierlaurent, A.; André, C.; Kroon, A.; Neubauer, A.; Chapman, M.; Vailes, L.; Tsay, A.; Durham, S.; Custovic, A.; Simpson, B.; Knulst, A.; Rivas, M. Fernández; Mancebo, E. Gonzalez; Bahima, A. Cistero; Moncin, M. M. San Miguel; Mari, A.; Kinaciyan, T.; Quiralte, J.; Pauli, G.; de Blay, F.; Purohit, A.; Rak, S.

    2008-01-01

    Allergen measurements are used extensively in the formulation of allergy diagnostics and vaccines, yet no purified international allergen standards are available for calibration purposes. The aims of the European Union CREATE project were to develop international standards with verifiable allergen

  20. Antimeningococcal and antipneumococcal vaccination determinants: a European systematic literature review.

    Science.gov (United States)

    Malerba, Valentina; Costantino, Claudio; Napoli, Giuseppe; Marchese, Valentina; Casuccio, Alessandra; Tabacchi, Garden; Vitale, Francesco

    2015-01-01

    ESCULAPIO is a multicenter project, funded by the Italian Centre for Disease Prevention and Control, aimed at implementing communication strategies to improve vaccination knowledge and attitudes among different target populations. The objective of the Sicilian research unit was, in the first phase, to identify, through systematic literature revision, which vaccination determinants play a role in the uptake of recommended vaccines included in the Italian Vaccination Plan. A systematic literature review was carried out on studies describing the determinants underlying pneumococcal and meningococcal vaccination uptake. The analysis was limited to papers published in English from 2000 to date. A total of 188 (meningococcal) and 731 (pneumococcal) papers were found. After selection by publication data, country (Europe), article type (original article), target population (healthy subjects), 7 (meningococcal) and 4 ( pneumococcal) manuscripts were finally included in the analysis. For meningococcal vaccination a better socioeconomic status is related to vaccination acceptance, whereas distance from immunization service is a negative determinant. For pneumococcal vaccination the determinants related to vaccination uptake are older parental age and a strong vaccine recommendation. Conversely, when the vaccine needs to be paid for, a refusal is more likely. Our results show that payment for vaccination is a major barrier and communication about meningococcal and pneumococcal vaccination should be targeted towards specific population groups, especially through the counseling activities by health professionals.

  1. Influenza vaccination coverage among high-risk groups in 11 European countries

    NARCIS (Netherlands)

    Loerbroks, A.; Stock, C.; Bosch, J.A.; Litaker, D.G.; Apfelbacher, C.J.

    BACKGROUND: National vaccination coverage rates for individuals at increased risk of influenza-related complications represent a useful public health indicator of preparedness. We compared European countries regarding (i) vaccination coverage among high-risk groups and (ii) the likelihood that

  2. European Integration and Outward FDI from Central and Eastern Europe

    DEFF Research Database (Denmark)

    Jindra, B.; Hassan, S. S.; Gunther, J.

    2015-01-01

    The European Union (EU) Member States in central and eastern Europe (CEE) witnessed a surge in outward foreign direct investment (OFDI) between 2000 and the start of the global financial crisis. This article investigates whether the European integration process altered the relative importance...... countries (CEECs) within the EU 27 (1996-2010). We find that the EU integration process is related with increasing importance of market access and less emphasis on labour cost advantages. We find heterogeneity in the valuation of foreign knowledge-related assets. The location probability within the EU15...

  3. Canine distemper of vaccine origin in European mink, Mustela lutreola--a case report.

    Science.gov (United States)

    Ek-Kommonen, C; Rudbäck, E; Anttila, M; Aho, M; Huovilainen, A

    2003-04-02

    Cases of canine distemper (CD) related to vaccination of exotic carnivores extend over three decades and have been described in at least nine different species. Our report describes a case of acute CD in a European mink, Mustela lutreola, vaccinated with live attenuated CD vaccine licensed for use in fur-farmed mink. The male mink died of an acute grey matter disease with an unusually long incubation period. A female vaccinated at the same time showed no obvious signs of illness. The diagnosis was confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR) and by subsequent sequencing of the PCR products. The sequenced products of the virus isolated from the mink and of the vaccine batch showed 100% identity. This is the first report in which molecular methods were used to confirm that the disease was caused by the vaccine strain. Based on our findings, it is clearly evident that current CD vaccines cannot be safely used in exotic species.

  4. Vaccination in European salmonid aquaculture: a review of practices and prospects.

    Science.gov (United States)

    Press, C M; Lillehaug, A

    1995-01-01

    Disease control by vaccination is widely used in European salmonid aquaculture against vibriosis (Vibrio anguillarum), cold-water vibriosis (Vibrio salmonicida), yersiniosis or enteric redmouth disease (Yersinia ruckeri) and furunculosis (Aeromonas salmonicida subsp. salmonicida). The vaccines against the Vibrio spp. and Y. ruckeri have proven effective especially when administered by injection. Furunculosis vaccines have been less successful and have relied on combination with potent adjuvants to achieve acceptable protection. Application of modern molecular techniques to furunculosis research has delivered a crop of experimental vaccines that incorporate purified virulence factors and have shown increased protection during challenge. Gene technology has also been used to create a defined, nonreverting mutation in a strain of A. salmonicida, which has enhanced the feasibility of attenuated live vaccines. The development of experimental subunit vaccines against the viral infections and the continued advances in the field of immunostimulants, adjuvants and antigen carriers provide considerable promise for the future development of commercial vaccines for use in salmonid aquaculture.

  5. European tools of conflict management in Central European states with Hungarian minorities

    NARCIS (Netherlands)

    Marácz, L.

    2010-01-01

    Due to twentieth century peace treaties extensive Hungarian minorities live in the Central-European states Slovakia (600.000), Serbia (400.000), Romania (1.5 million) and Ukraine (300.000). These states are deeply divided along ethnic-linguistic, religious and cultural lines between the Hungarian

  6. Forming Professional Competency of Education Managers in Central European Countries

    Directory of Open Access Journals (Sweden)

    Tovkanets Oksana

    2017-03-01

    Full Text Available The article deals with the problem of forming education managers’ professional competency in the context of European integration educational processes. The peculiarities of education managers’ competences as well as directions of their professional training in motivational, cognitive and metacognitive spheres have been theoretically justified. The performed analysis of curricula in higher education institutions of Central European countries has proved their use of the complex approach to forming professional competences of education managers. The author has revealed the peculiarities of education managers’ professional training while mastering accredited specialized courses in School Management in the Centre for Lifelong Education at Faculty of Education at Palacký University in Olomouc, the Czech Republic; a Bachelor’s degree in Education Specialization (School Management at Charles University in Prague, the Czech Republic; in the context of the project launched by the European Social Fund (EFS called “The Development of Education Managers’ Competences in Schools and Educational Institutions in the Hradec Králové Region – the Model of Professional Education”, the Czech Republic. It has been concluded that higher education institutions of Central European countries focus on the development of pedagogical and managerial competencies. It has been highlighted that the complication of training content and the modernization of disciplines will allow to form thinking and actions of education managers as comprehensively educated specialists able to successfully deal with professional tasks using their educational and intellectual potential.

  7. The Eighth Central European Conference ?Chemistry towards Biology?: Snapshot?

    OpenAIRE

    Perczel, Andr?s; Atanasov, Atanas G.; Sklen??, Vladim?r; Nov??ek, Ji??; Papou?kov?, Veronika; Kade??vek, Pavel; ??dek, Luk??; Koz?owski, Henryk; Wat?y, Joanna; Hecel, Aleksandra; Ko?kowska, Paulina; Ko?a, Jaroslav; Svobodov?-Va?ekov?, Radka; Pravda, Luk??; Sehnal, David

    2016-01-01

    The Eighth Central European Conference “Chemistry towards Biology” was held in Brno, Czech Republic, on August 28–September 1, 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topics of the conference covered “Chemistry towards Biology”, meaning that the event welcomed chemists working on biology-related problems, biol...

  8. Exploring central governments' coordination of European Union affairs

    DEFF Research Database (Denmark)

    Jensen, Mads Christian Dagnis

    2017-01-01

    and between the structures and processes of EU coordination, the actors involved, and the mechanisms' efficacy. The analysis shows that highly formalized coordination mechanisms are associated with developing timely, clear and consistent negotiation positions. The second part allocates the 28 member states......' EU coordination mechanisms into different clusters, including unicentric, pluricentric, decentric, proactive, reactive, politicized, depoliticized, high efficacy and low efficacy. Intriguing differences are identified, such as the fact that the Central and Eastern European member states' mechanisms...

  9. Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?

    DEFF Research Database (Denmark)

    Thøgersen, Regitze L; Holder, Anthony A; Hill, Adrian Vs

    2011-01-01

    ABSTRACT: Since 2000, under the Fifth and subsequent Framework Programmes, the European Commission has funded research to spur the development of a malaria vaccine. This funding has contributed to the promotion of an integrated infrastructure consisting of European basic, applied and clinical...... scientists in academia and small and medium enterprises, together with partners in Africa. Research has added basic understanding of what is required of a malaria vaccine, allowing selected candidates to be prioritized and some to be moved forward into clinical trials. To end the health burden of malaria......, and its economic and social impact on development, the international community has now essentially committed itself to the eventual eradication of malaria. Given the current tentative advances towards elimination or eradication of malaria in many endemic areas, malaria vaccines constitute an additional...

  10. Differences in national influenza vaccination policies across the European Union, Norway and Iceland 2008-2009.

    LENUS (Irish Health Repository)

    Mereckiene, J

    2010-01-01

    In 2009 the second cross-sectional web-based survey was undertaken by the Vaccine European New Integrated Collaboration Effort (VENICE) project across 27 European Union (EU) member states (MS), Norway and Iceland (n=29) to determine changes in official national seasonal influenza vaccination policies since a survey undertaken in 2008 and to compare the estimates of vaccination coverage between countries using data obtained from both surveys. Of 27 responding countries, all recommended vaccination against seasonal influenza to the older adult population. Six countries recommended vaccination of children aged between six months and <18 years old. Most countries recommended influenza vaccination for those individuals with chronic medical conditions. Recommendations for vaccination of healthcare workers (HCW) in various settings existed in most, but not all countries. Staff in hospitals and long-term care facilities were recommended vaccination in 23 countries, and staff in out-patient clinics in 22 countries. In the 2009 survey, the reported national estimates on vaccine coverage varied by country and risk group, ranging from 1.1% - 82.6% for the older adult population; to between 32.9% -71.7% for clinical risk groups; and from 13.4% -89.4% for HCW. Many countries that recommend the influenza vaccination do not monitor the coverage in risk groups. In 2008 and 2009 most countries recommended influenza vaccination for the main risk groups. However, despite general consensus and recommendations for vaccination of high risk groups, many countries do not achieve high coverage in these groups. The reported vaccination coverage still needs to be improved in order to achieve EU and World Health Organization goals.

  11. The Views of Young Women on HPV Vaccine Communication in Four European Countries.

    Science.gov (United States)

    Petrova, Dafina; Brunton, Carol Gray; Jaeger, Moritz; Lenneis, Anita; Munoz, Rocio; Garcia-Retamero, Rocio; Todorova, Irina

    2015-01-01

    The Human Papilloma Virus (HPV) is the most common sexually transmitted infection (STI) and can cause cervical cancer. Two vaccines are available to protect against the most common strands of the virus. Vaccination programs differ across Europe but most neglect young adults, who are the group with the highest risk of contracting STIs. Our aim was to explore the views of young women from four European countries—Scotland, Spain, Serbia, and Bulgaria - about the HPV vaccine communication strategy. These countries are characterized by different cervical cancer prevalence and vaccine implementation policies. We conducted focus group discussions with young women (aged 18-26) with various vaccination histories in a purposive sample. We subjected the data to thematic analysis with the purpose of identifying themes related to communication about the HPV vaccine. We recorded the information sources mentioned by participants. Participants discussed numerous sources of vaccine-related information. They approached information critically rather than naively and questioned the sources' trustworthiness and motives. Participants desired transparent information about the risks of the virus and the risks and benefits of the vaccine. These risks and benefits were individualized in view of personal and external factors. Particular aspects of the vaccine and the way information was communicated resulted in feelings of uncertainty. There were notable cross-cultural differences in experiences with HPV vaccine communication. Our results suggest that transparent risk communication about the HPV vaccine is valued by young women. In addition, both individual and culturally-dependent factors influenced experiences with, and preference for information.

  12. EDITORIAL: The 15th Central European Workshop on Quantum Optics The 15th Central European Workshop on Quantum Optics

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita; Arsenovic, Dusan

    2009-07-01

    The development of quantum optics was part and parcel of the formation of modern physics following the fundamental work of Max Planck and Albert Einstein, which gave rise to quantum mechanics. The possibility of working with pure quantum objects, like single atoms and single photons, has turned quantum optics into the main tool for testing the fundamentals of quantum physics. Thus, despite a long history, quantum optics nowadays remains an extremely important branch of physics. It represents a natural base for the development of advanced technologies, like quantum information processing and quantum computing. Previous Central European Workshops on Quantum Optics (CEWQO) took place in Palermo (2007), Vienna (2006), Ankara (2005), Trieste (2004), Rostock (2003), Szeged (2002), Prague (2001), Balatonfüred (2000), Olomouc (1999), Prague (1997), Budmerice (1995, 1996), Budapest (1994) and Bratislava (1993). Those meetings offered excellent opportunities for the exchange of knowledge and ideas between leading scientists and young researchers in quantum optics, foundations of quantum mechanics, cavity quantum electrodynamics, photonics, atom optics, condensed matter optics, and quantum informatics, etc. The collaborative spirit and tradition of CEWQO were a great inspiration and help to the Institute of Physics, Belgrade, and the Serbian Academy of Sciences and Arts, as the organizers of CEWQO 2008. The 16th CEWQO will take place in 2009 in Turku, Finland, and the 17th CEWQO will be organized in 2010 in St Andrews, United Kingdom. The 15th CEWQO was organized under the auspices and support of the Ministry of Science of the Republic of Serbia, the Serbian Physical Society, the European Physical Society with sponsorship from the University of Belgrade, the Central European Initiative, the FP6 Program of the European Commission under INCO project QUPOM No 026322, the FP7 Program of the European Commission under project NANOCHARM, Europhysics Letters (EPL), The European

  13. CENTRAL AND EASTERN EUROPEAN COUNTRIES IN EUROPEAN UNION IMPACT OF FOREIGN DIRECT INVESTMENTS

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    Carmen Apolzan

    2010-12-01

    Full Text Available Economic integration refers to trade unification between different states , and one of its most important aspects is liberalisation of capital movement. In this paper is presented a brief evolution of economic integration cases focusing on one of the most integrated economies European Union. We concentrate on the participation of foreign investors in different economies and their impact, taking the example of Central and Eastern European Countries and their markets. Also , the level of influence that direct investments in capital markets entails on the Stock Exchange evolution is presented for the case of Romania .

  14. FMD vaccines: reflections on quality aspects for applicability in European disease control policy.

    Science.gov (United States)

    De Clercq, K; Goris, N; Barnett, P V; MacKay, D K

    2008-01-01

    Most foot-and-mouth disease (FMD) vaccines used around the world are inactivated vaccines for prophylactic or emergency use, generally manufactured by the same basic methodology outlined in the OIE Manual and, for Europe, in the European Pharmacopoeia, and for the EU Member States in compliance with Directive 2001/82/EC of the European Parliament and of the Council of 6 November 2001 on the Community code relating to veterinary medicinal products as amended by Directive 2004/28/EC. Most of the requirements that apply to all immunological veterinary medicinal products apply equally to FMD vaccines. There are, however, some unique features of the disease and vaccines used against it that require a different approach to fulfil the requirements of the relevant legislation, if a vaccinate-to-live policy will be applied with 'authorized' vaccines. Several aspects of vaccine efficacy and safety are elaborated with emphasis on quality assurance/quality control (QA/QC). The purity of the vaccine in respect of the presence of non-structural protein antibodies could be checked indirectly by serology after vaccination. The viability of a vaccine bank approach was greatly aided by the principle of storing inactivated concentrated FMD viral antigen (Ag) over liquid nitrogen for subsequent formulation into vaccine. A worldwide Ag bank network might be an option for the far future and a solution to the problem of covering many different FMDV serotypes and strains. The producers should respect the strict FMD biosecurity rules worked out by the FAO EUFMD and described in Council Directive 2003/85/EC. Making the experience related to vaccine QA/QC available to all countries will reduce the risk of an FMD outbreak within these countries and consequently will reduce the FMD risk around the world.

  15. Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?

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    Imoukhuede Egeruan B

    2011-09-01

    Full Text Available Abstract Since 2000, under the Fifth and subsequent Framework Programmes, the European Commission has funded research to spur the development of a malaria vaccine. This funding has contributed to the promotion of an integrated infrastructure consisting of European basic, applied and clinical scientists in academia and small and medium enterprises, together with partners in Africa. Research has added basic understanding of what is required of a malaria vaccine, allowing selected candidates to be prioritized and some to be moved forward into clinical trials. To end the health burden of malaria, and its economic and social impact on development, the international community has now essentially committed itself to the eventual eradication of malaria. Given the current tentative advances towards elimination or eradication of malaria in many endemic areas, malaria vaccines constitute an additional and almost certainly essential component of any strategic plan to interrupt transmission of malaria. However, funding for malaria vaccines has been substantially reduced in the Seventh Framework Programme compared with earlier Framework Programmes, and without further support the gains made by earlier European investment will be lost.

  16. Tracking parental attitudes on vaccination across European countries: The Vaccine Safety, Attitudes, Training and Communication Project (VACSATC).

    Science.gov (United States)

    Stefanoff, Pawel; Mamelund, Svenn-Erik; Robinson, Mary; Netterlid, Eva; Tuells, Jose; Bergsaker, Marianne A Riise; Heijbel, Harald; Yarwood, Joanne

    2010-08-09

    The paper presents the first results from the European project VACSATC which aimed to track parental attitudes on vaccinations across several European countries. We compared five cross-sectional surveys of parents with children less than 3 years of age in England, Norway, Poland, Spain and Sweden carried out during 2008-2009. Data were collected from 6611 respondents. Two countries used face-to face interviews, one used telephone interviews, and two other countries used mail-in questionnaires. In all countries health professionals were indicated as the most important and trusted source of information on vaccination. The study results also show that parental attitudes on vaccinations in the childhood vaccination programs are generally positive. However, there were differences in attitudes on vaccination between the five countries, possibly reflecting different methods of sampling the respondents, context-specific differences (e.g. level of activity of governmental agencies), but also individual-level parental variation in demographic and socioeconomic status variables. Copyright 2010 Elsevier Ltd. All rights reserved.

  17. Sovereign Credit Risk, Liquidity, and European Central Bank Intervention

    DEFF Research Database (Denmark)

    Pelizzon, Loriana; Subrahmanyam, Marti G.; Tomio, Davide

    2016-01-01

    We examine the dynamic relation between credit risk and liquidity in the Italian sovereign bond market during the eurozone crisis and the subsequent European Central Bank (ECB) interventions. Credit risk drives the liquidity of the market. A 10% change in the credit default swap (CDS) spread leads...... to a 13% change in the bid-ask spread, the relation being stronger when the CDS spread exceeds 500 basis points. The Long-Term Refinancing Operations of the ECB weakened the sensitivity of market makers’ liquidity provision to credit risk, highlighting the importance of funding liquidity measures...... as determinants of market liquidity....

  18. MACROECONOMIC STABILITY OF CENTRAL AND EASTERN EUROPEAN COUNTRIES

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    Arnold WEISZENBACHER

    2014-10-01

    Full Text Available In the context of the recent financial crisis, the macroeconomic stability of most countries has been cast to shadow. The damage to the economy caused by high inflation, volatile exchange rates, increasing amount of debts and the unstable financial markets has heavily left its toll on the global market and has led to massive unemployment and increasing poverty. This paper aims to follow the eight new Central and Eastern European countries that joined the European Union in 2004, as well as Romania and Bulgaria, who followed suit in 2007, in what concerns their economical performance, following adhesion to the EU while also comparing the periods before and after the economical crisis. They were chosen as a topic of research for the severity with which the crisis affected them and the high degree of reform implementation in the aftermath. It also plans to highlight the effect of the new reforms and the growth potential when compared to the rest of the European Union. The price inflation, real GDP growth, the levels of (unemployment, fiscal policy and stability of exchange rates will provide a clear image of how this cluster of developing countries fare nowadays against the rest of the EU countries.

  19. SUSTAINABLE DEVELOPMENT AND INNOVATION IN EASTERN AND CENTRAL EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    NEAGU OLIMPIA

    2016-12-01

    Full Text Available The paper has the aim to highlight the impact of innovation on sustainable development in Eastern and Central European countries. In this wiew, a sinthetic measure of sustainability in these countries is calculated, taking into account ten statistical indicators (related to socio-economic development, sustainable consumption and production, social inclusion, demographic changes, public health, primary energy consumption, share of renewable energy in final consumption energy, sustainable transport, official development assistance granted to these countries from EUROSTAT database. A comparative analysis of the level of sustainability during 2005-2014 in Eastern and Central Europe is followed by an analysis of the impact of innovation (measured by eco-innovation index on sustainable development, using panel data techniques. The findings show that eco-innovation had a positive impact on sustainability in these countries in the examined period.This result could be used as a rationale for policy makers from these countries in designing measures for eco-innovation stimulation, aiming in this way to move forward for achieving the planned national targets within the European Union Sustainable Development Strategy (EU-SDS.

  20. Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus.

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    Babs E Verstrepen

    Full Text Available The mosquito-borne West Nile virus (WNV causes human and animal disease with outbreaks in several parts of the world including North America, the Mediterranean countries, Central and East Europe, the Middle East, and Africa. Particularly in elderly people and individuals with an impaired immune system, infection with WNV can progress into a serious neuroinvasive disease. Currently, no treatment or vaccine is available to protect humans against infection or disease. The goal of this study was to develop a WNV-vaccine that is safe to use in these high-risk human target populations. We performed a vaccine efficacy study in non-human primates using the contemporary, pathogenic European WNV genotype 1a challenge strain, WNV-Ita09. Two vaccine strategies were evaluated in rhesus macaques (Macaca mulatta using recombinant soluble WNV envelope (E ectodomain adjuvanted with Matrix-M, either with or without DNA priming. The DNA priming immunization was performed with WNV-DermaVir nanoparticles. Both vaccination strategies successfully induced humoral and cellular immune responses that completely protected the macaques against the development of viremia. In addition, the vaccine was well tolerated by all animals. Overall, The WNV E protein adjuvanted with Matrix-M is a promising vaccine candidate for a non-infectious WNV vaccine for use in humans, including at-risk populations.

  1. Salt movements within the Central European basin system

    Energy Technology Data Exchange (ETDEWEB)

    Maystrenko, Yuriy; Bayer, Ulf; Scheck-Wenderoth [GeoForschungsZentrum (GFZ), Potsdam (Germany); Littke, Ralf [RWTH Aachen (Germany). Lehrstuhl fuer Geologie, Geochemie und Lagerstaetten des Erdoels und der Kohle

    2010-04-15

    Evolution of salt structures in relation to tectonic events within central part of the Central European Basin System is described by summarizing results which have been obtained and published in frame of the research project DFG-SPP 1135. These results illustrate main phases of salt tectonics within the basin system from the Triassic to present day. During the Buntsandstein and Muschelkalk, extension triggered raft tectonics and salt movements within the Ems Trough, the Glueckstadt and the Horn Grabens. The next phase of salt movements occurred in response to a Middle-Late Keuper regional extensional event which was strongest within the Triassic depocenters of the Central European Basin System, such as the Horn Graben, the Glueckstadt Graben, the Ems and the Rheinsberg Troughs. Regional erosion truncated the study area during the Late Jurassic-Early Cretaceous time. The magnitude of Late Jurassic-Early Cretaceous erosion is declining towards southern margin of the basin system where a dextral transtensional regime was established in the Lower Saxony Basin and neighboring areas during the Late Jurassic-Early Cretaceous. The late Early Cretaceous-early Late Cretaceous is characterized by a relative tectonic quiescence without strong salt movements. The Late Cretaceous-Early Cenozoic inversion provocated renewed salt movements, causing the thick-skinned salt tectonics along the Elbe Fault System and the thin-skinned character of salt movements towards the north from the area of strain localisation. Post-inversion Cenozoic subsidence was accompanied by salt movements, related either to diapiric rise due to regional shortening and/or to local almost E-W directed extension. (orig.)

  2. Communities, households and animals. Convergent developments in Central Anatolian and Central European Neolithic

    Directory of Open Access Journals (Sweden)

    Arkadiusz Marciniak

    2008-12-01

    Full Text Available This paper intends to scrutinize striking similarities in cultural developments and social transformations in Neolithic communities in the North European Plain of Central Europe and Central Anatolia in the early phase of their development and in the following post-Eearly Neolithic period. They will be explored through evidence pertaining to architecture and the organization of space, alongside changes in settlement pattern, as well as animal bone assemblages and zoomorphic representations. Social changes, in particular a transition from communal arrangements of local groups in the Early Neolithic to autonomous household organization in the following period, will be debated.

  3. SUSTAINABLE GROWTH: RECENT TRENDS ACROSS CENTRAL AND EASTERN EUROPEAN ECONOMIES

    Directory of Open Access Journals (Sweden)

    Mihut Ioana

    2014-07-01

    Full Text Available What is economic growth? Although the answer to this question may seems of real simplicity, developing an accurate definition of this concept may constitute a real challenge both from a theoretical but also empirical point of view. This constant debate upon the concept of economic growth as well as indentifying the optimum set of instruments for quantifying it, constituted the starting point of the current article. The concept of economic growth is used nowadays complementary to terms like economic development, economic welfare or economic progress with reference to this complex process that implies macro-scale structures. Moreover indentifying the main factors that generate a significant impact upon the dynamics of the economic growth process, constitute a useful approach taking into consideration the high degree of heterogeneity that characterize the architecture of the economies around the world. If we develop this analysis across the European Union member states this debate became even more challenging due to the high degree of diversity that characterize these economies. Moreover, the Central and Eastern European countries and especially the ones that joined EU in 2004 and 2007 embody a set of particularities that make them extremely different from the rest of the European Union member states, features related to the historical background, economic policies and common efforts to intensify the convergence process with the more developed EU members. This paper studies the impact of two main factors upon the economic growth process namely an endogenous-exogenous factor like the degree of openness and an endogenous factor like the human capital using a complex dynamic panel method. The arguments that were in favour of choosing this two factors are on one hand the multitude of theoretical studies that argued the importance of them in modelling the economic growth process and on the other hand the small number of studies that use panel methods in

  4. I-MOVE: a European network to measure the effectiveness of influenza vaccines.

    Science.gov (United States)

    Valenciano, M; Ciancio, Bc

    2012-09-27

    Since 2007, the European Centre for Disease Prevention and Control (ECDC) has supported I-MOVE (influenza monitoring vaccine effectiveness), a network to monitor seasonal and pandemic influenza vaccine effectiveness (IVE) in the European Union (EU) and European Economic Area (EEA). To set up I-MOVE, we conducted a literature review and a survey on methods used in the EU/EEA to measure IVE and held expert consultations to guide the development of generic protocols to estimate IVE in the EU/EEA. On the basis of these protocols, from the 2008/09 season, I-MOVE teams have conducted multicentre case–control, cohort and screening method studies, undertaken within existing sentinel influenza surveillance systems. The estimates obtained include effectiveness against medically attended laboratory-confirmed influenza and are adjusted for the main confounding factors described in the literature. I-MOVE studies are methodologically sound and feasible: the availability of various study designs, settings and outcomes provides complementary evidence, facilitating the interpretation of the results. The IVE estimates have been useful in helping to guide influenza vaccine policy at national and European level. I-MOVE is a unique platform for exchanging views on methods to estimate IVE. The scientific knowledge and experience in practical, managerial and logistic issues can be adapted to monitor surveillance of the effectiveness of other vaccines.

  5. Economic evaluation of vaccines : specificities and future challenges illustrated by recent European examples

    NARCIS (Netherlands)

    Postma, M.J.; Westra, T.A.; Quilici, S.; Largeron, N.

    2013-01-01

    This study reviews the current challenges in the economic evaluation of vaccines with a focus on European countries. In particular, the type of clinical evidence generally available, the impact of discounting for time preference and the use of modeling to derive valid cost-effectiveness assessments

  6. Economic evaluation of vaccines : specificities and future challenges illustrated by recent European examples

    NARCIS (Netherlands)

    Postma, Maarten J; Westra, Tjalke A; Quilici, Sibilia; Largeron, Nathalie

    This study reviews the current challenges in the economic evaluation of vaccines with a focus on European countries. In particular, the type of clinical evidence generally available, the impact of discounting for time preference and the use of modeling to derive valid cost-effectiveness assessments

  7. Morphological separation of the Central European Trochosa females (Araneae, Lycosidae

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    Hepner, Martin

    2006-06-01

    Full Text Available Adult females of the five Central European wolf spiders Trochosa hispanica Simon, 1870, T. robusta (Simon, 1876, T. ruricola (DeGeer, 1778, T. spinipalpis (F.O.P.-Cambridge, 1895, and T. terricola Thorell, 1856 were morphologically analysed. We defined sets of continuous and binary (presence/absence variables. Continuous data of various epigynal and carapace dimensions were subjected to Principal Component Analysis (PCA. Using the PC loadings each individual was plotted along the PC axis in order to find gaps(overlaps between the species. The binary data sets were subjected to Hierarchical Cluster Analysis (HCA in order to find characters that clearly separate the five Trochosa species. Using PCA only individuals of T.robusta and T.ruricola and of T.robusta and T.hispanica could be separated from each other. Using HCA all five species could clearly be separated by epigynal and vulval characteristics."

  8. The Eighth Central European Conference "Chemistry towards Biology": Snapshot.

    Science.gov (United States)

    Perczel, András; Atanasov, Atanas G; Sklenář, Vladimír; Nováček, Jiří; Papoušková, Veronika; Kadeřávek, Pavel; Žídek, Lukáš; Kozłowski, Henryk; Wątły, Joanna; Hecel, Aleksandra; Kołkowska, Paulina; Koča, Jaroslav; Svobodová-Vařeková, Radka; Pravda, Lukáš; Sehnal, David; Horský, Vladimír; Geidl, Stanislav; Enriz, Ricardo D; Matějka, Pavel; Jeništová, Adéla; Dendisová, Marcela; Kokaislová, Alžběta; Weissig, Volkmar; Olsen, Mark; Coffey, Aidan; Ajuebor, Jude; Keary, Ruth; Sanz-Gaitero, Marta; van Raaij, Mark J; McAuliffe, Olivia; Waltenberger, Birgit; Mocan, Andrei; Šmejkal, Karel; Heiss, Elke H; Diederich, Marc; Musioł, Robert; Košmrlj, Janez; Polański, Jarosław; Jampílek, Josef

    2016-10-17

    The Eighth Central European Conference "Chemistry towards Biology" was held in Brno, Czech Republic, on August 28-September 1, 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topics of the conference covered "Chemistry towards Biology", meaning that the event welcomed chemists working on biology-related problems, biologists using chemical methods, and students and other researchers of the respective areas that fall within the common scope of chemistry and biology. The authors of this manuscript are plenary speakers and other participants of the symposium and members of their research teams. The following summary highlights the major points/topics of the meeting.

  9. Determinants of SME Finance: Evidence from Three Central European Countries

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    Rahman Ashiqur

    2017-09-01

    Full Text Available This paper explores the determinants of access to finance for small and medium enterprises (SMEs in the context of three Central European countries: Czech Republic, Slovak Republic, and Hungary. The data set of the research is obtained from the BEEPS survey, which is conducted by the World Bank and the European Bank for Reconstruction and Development. This paper empirically analyses firms not only from the SMEs point of view, but also shows results for micro, small and medium enterprises separately. Additionally, we have analysed the determinants of access to finance for SMEs at each country level for an in-depth understanding of country-level variations in SME financing. The results indicate that micro firms and firms owned and operated by women are experiencing a shortage of credits from banks. On the other hand, we found a positive relationship between the pledge of collateral and access to finance. With respect to the medium firms, we found evidence that innovative firms have a larger amount of credit from banks. The empirical results also suggest that the loan size increases as the interest rates increase in particular for SMEs on the whole and for micro-firms, although the interest rate is in a negative relationship with the loan size in Czech Republic.

  10. Disposable and Usable Pasts in Central European Cities

    Directory of Open Access Journals (Sweden)

    Agata Lisiak

    2009-12-01

    Full Text Available In Central European cities memories and material histories of socialist regimes remain particularly difficult to address and incorporate into the new democratic present. After 1989, city authorities in the region have chosen to emphasize some pasts and neglect others and, thus, (rewrite their own versions of (urban history and (reshape their (urban identities. In my paper I inquire into how post-1989 Central European urbanities are shaped by and communicated through various designations including signs and symbols on city streets, monuments, and build-ings. Predictably, many material remnants of the socialist regimes have been de-stroyed or hidden from the public eye - my interest lies not only in which various designations on buildings and which monuments had to go, but also in why and how they disappeared. I discuss the most popular methods of hiding and/or effac-ing the remnants of socialism that range from subtle (surrounding of communist landmarks with tall buildings through the obvious (renaming of streets, squares, metro stations; giving old communist buildings new names and functions to the irreversible and, thus, most controversial (the razing of socialist architecture and monuments. The disappearance of the material capital of the socialist past has been accompanied by intense commemoration practices verging on memorial ob-sessions. New monuments, plaques, street names, and museums appeared almost as quickly as the old "disposable" ones were forced out from the urban landscape. The complexity of an urban identity as communicated through city streets, mo-numents, and buildings not only invites, but necessitates an interdisciplinary ap-proach and, thus, my analysis includes elements from such diverse areas of know-ledge as aesthetics, architecture, communication studies, comparative cultural studies, economics, history, and political science.

  11. Economic evaluation of vaccines: specificities and future challenges illustrated by recent European examples.

    Science.gov (United States)

    Postma, Maarten J; Westra, Tjalke A; Quilici, Sibilia; Largeron, Nathalie

    2013-05-01

    This study reviews the current challenges in the economic evaluation of vaccines with a focus on European countries. In particular, the type of clinical evidence generally available, the impact of discounting for time preference and the use of modeling to derive valid cost-effectiveness assessments are considered. First, the characteristics of evidence for vaccines are discussed, as well as potential difficulties faced when using evidence-based medicine applied to curative drugs to interpret vaccine evidence. Then, discounting is considered and specific examples illustrating issues with different types of discounting are described, taking HPV as the example. Finally, the need for sometimes complex dynamic models for vaccines is explored, and specific types of models are reviewed, keeping into consideration the adage "complex when needed, straightforward if allowed."

  12. Rotavirus gastroenteritis in uzbekistan: implications for vaccine policy in central Asia.

    Science.gov (United States)

    Flem, Elmira T; Musabaev, Erkin; Juraev, Rivojiddin; Kerin, Tara; Gentsch, Jon; Glass, Roger I; Bresee, Joseph S

    2009-11-01

    To determine the value of rotavirus vaccines in Central Asia, we conducted surveillance of rotavirus in Uzbekistan, the country with the largest birth cohort in the region. Uzbekistan is eligible for international funds to introduce new vaccines. We screened stool samples for rotavirus that were collected from children aged Uzbekistan may be attributable to rotavirus. Introduction of rotavirus vaccines into the national immunization program at the current subsidized prices could be cost-effective.

  13. Incertitude, Hepatitis B, and Infant Vaccination in West and Central Africa.

    Science.gov (United States)

    Giles-Vernick, Tamara; Traoré, Abdoulaye; Bainilago, Louis

    2016-06-01

    This comparative study explores incertitude about hepatitis B (HBV) and its implications for childhood vaccination in Bangui, Central African Republic, and the Cascades region, Burkina Faso. Anthropological approaches to vaccination, which counter stereotypes of "ignorant" publics needing education to accept vaccination, excavate alternative ways of knowing about illness and vaccination. We build on these approaches, evaluating different kinds of incertitude (ambiguity, uncertainty, ignorance) about infancy, HBV, health protection, and vaccination. Using interviews and participant observation, we find that Bangui and Cascades publics framed their incertitude differently through stories of infancy, illness, and protection. We locate different forms of incertitude within their historical contexts to illuminate why vaccination practices differ in the Cascades region and Bangui. A more nuanced approach to incomplete knowledge, situated in political, economic, and social histories of the state and vaccination, can contribute to more appropriate global health strategies to improve HBV prevention. © 2016 by the American Anthropological Association.

  14. [Mechanics and effects of European reference pricing for vaccines in Germany according to §130a Abs. 2 SGB V: an analysis using the example of influenza vaccines].

    Science.gov (United States)

    Barth, J; Hammerschmidt, T; Vollmar, J; Bierbaum, M; Schöffski, O

    2014-04-01

    On 01 January 2011 the bill for the reorganisation of the pharmaceutical market became effective. Since that time there is a European reference pricing (ERP) system for vaccines in order to bring down the German vaccine prices to an assumed lower European level. This study describes the implementation, functioning and effect of this new system. For influenza vaccines the impact of ERP on the price level and spread of prices is analysed. The description of the mechanism is based on the law and corresponding regulations of the head association of sickness funds (GKV-SV). The analysis of vaccine prices is based on the data of the i:data report (status of 01 September 2011) of ifap Service Institute. The European reference price is calculated as the average price of the manufacturer-selling-prices of the corresponding vaccine in the 4 countries of the European Union whose gross national income comes closest to the German one and in which the vaccine is distributed. The relied prices are weighted by sales and purchasing power parities of the respective countries. This analysis suggests that in particular the practical implementation of the reference price system should be further improved and specified. The calculation of the reference prices should ensure price comparability. In addition, significant problems remain in the deduction of discounts, because no distinction is made in the documentation of vaccinating doctors, whether vaccination was performed as a compulsory or statutory benefit. The comparison of the manufacturer-selling-prices of individual influenza vaccines with the corresponding reference prices shows an enlargement of the existing price differences, which have evolved in a competitive environment, after the implementation of the reference pricing -system. There is still a need for improvement in implementing the reference pricing system. In the most competitive vaccine market of influenza vaccines, the ERP-system lowers the prices, but seems to

  15. Epidemiology of tick-borne encephalitis (TBE) in international travellers to Western/Central Europe and conclusions on vaccination recommendations.

    Science.gov (United States)

    Steffen, Robert

    2016-04-01

    Tick-borne encephalitis (TBE) endemicity is spreading in Europe becoming an increasing health risk also for travellers. Previous reviews on TBE in civilian travellers lacked of numerator data and offered at most rough estimates on denominator data. An evidence-based quantification of the risk so far has been impossible; that resulted in fundamentally differing vaccination recommendations. A standard internet search was conducted with a focus on the data used to formulate vaccination recommendations. As TBE became notifiable at the European Union (EU) level the databases of European Center for Disease Prevention and Control (ECDC) were analysed for cases imported from abroad 2012. Since these included only 19 EU countries, individual experts were contacted in countries, which had not submitted data and additional surveillance databases were investigated to obtain a comprehensive account on travel-associated TBE in Central and Western Europe. In 2012, the ECDC and other data sources included 38 reported cases of internationally acquired TBE. Basing on estimates of the exposed number of visitors, the attack rate for an undefined period of time could be very roughly extrapolated to be 0.5-1.3 per 100,000 (1 per 77,000-200.000) overall in Western/Central Europe endemic areas for the exposed at-risk population. As advised by the World Health Organization (WHO) travellers exposed outdoors in rural endemic areas to a risk of TBE during the period of transmission should be recommended immunization. In contrast, the advice to recommend TBE vaccination for all visitors of endemic areas is inappropriate. Implementation of the risk strategy is compromised by the fact that many at-risk travellers are unaware of the risk, thus they will not consult competent health professionals. Others may consult late, and in some countries of origin no TBE vaccine is marketed. © International Society of Travel Medicine, 2016. All rights reserved. Published by Oxford University Press. For

  16. Controlling of CSFV in European wild boar using oral vaccination: a review

    Directory of Open Access Journals (Sweden)

    Sophie eRossi

    2015-10-01

    Full Text Available Classical swine fever (CSF is among the most detrimental diseases for the swine industry worldwide. Infected wild boar populations can play a crucial role in CSF epidemiology and controlling wild reservoirs is of utmost importance for preventing domestic outbreaks. Oral mass vaccination (OMV has been implemented to control CSF in wild boars and limit the spill over to domestic pigs. This retrospective overview of vaccination experiences illustrates the potential for that option. The C-strain live vaccine was confirmed to be highly efficacious and palatable baits were developed for oral delivery in free ranging wild boars. The first field trials were performed in Germany in the 1990’s and allowed deploying oral baits at a large scale. The delivery process was further improved during the 2000’s among different European countries. Optimal deployment has to be early regarding disease emergence and correctly designed regarding the landscape structure and the natural food sources that can compete with oral baits. OMV deployment is also highly dependent on a local veterinary support working closely with hunters, wildlife and forestry agencies. Vaccination has been the most efficient strategy for CSF control in free ranging wild boar when vaccination is wide spread and lasting for a sufficient period of time. Alternative disease control strategies such as intensified hunting or creating physical boundaries such as fences have been, in contrast, seldom satisfactory and reliable. However, monitoring outbreaks has been challenging during and after vaccination deployment since OMV results in a low probability to detect virus-positive animals and the live-vaccine currently available does not allow serological differentiation of infected from vaccinated animals. The development of a new marker vaccine and companion test is thus a promising option for better monitoring outbreaks during OMV deployment as well as help to better determine when to stop

  17. EDITORIAL The 17th Central European Workshop on Quantum Optics

    Science.gov (United States)

    Man'ko, Margarita A.

    2011-02-01

    Although the origin of quantum optics can be traced back to the beginning of the 20th century, when the fundamental ideas about the quantum nature of the interaction between light and matter were put forward, the splendid blossoming of this part of physics began half a century later, after the invention of masers and lasers. It is remarkable that after another half a century the tree of quantum optics is not only very strong and spreading, but all its branches continue to grow, showing new beautiful blossoms and giving very useful fruits. A reflection of this progress has been the origin and development of the series of annual events called the Central European Workshops on Quantum Optics (CEWQO). They started at the beginning of the 1990s as rather small meetings of physicists from a few countries in central-eastern Europe, but in less than two decades they have transformed into important events, gathering 100 to 200 participants from practically all European countries. Moreover, many specialists from other continents like to attend these meetings, since they provide an excellent chance to hear about the latest results and new directions of research. Regarding this, it seems worth mentioning at least some of the most interesting and important areas of quantum optics that have attracted the attention of researchers for the past two decades. One of these areas is quantum information, which over the course of time has become an almost independent area of quantum physics. But it still maintains very close ties with quantum optics. The specific parts of this area are, in particular, quantum computing, quantum communication and quantum cryptography, and the problem of quantitative description of such genuine quantum phenomena as entanglement is one of the central items in the current stream of publications. Theory and experiment related to quantum tomography have also become important to contemporary quantum optics. They are closely related to the subject of so

  18. Vaccine adverse event monitoring systems across the European Union countries: time for unifying efforts.

    LENUS (Irish Health Repository)

    Zanoni, Giovanna

    2009-05-26

    A survey conducted among 26 European Countries within the Vaccine European New Integrated Collaboration Effort (VENICE) project assessed the status of organization in prevention and management of adverse events following immunization (AEFI) and level of interconnection, with the aim at individuating points of strength and weakness. The emerging picture is for a strong political commitment to control AEFIs in Member States (MS), but with consistent heterogeneity in procedures, regulations and capacity of systems to collect, analyze and use data, although with great potentialities. Suggestions are posed by authors to promote actions for unifying strategies and policies among MS.

  19. Heterologous challenge with porcine reproductive and respiratory syndrome (PRRS) vaccine virus: no evidence of reactivation of previous European-type PRRS virus infection

    DEFF Research Database (Denmark)

    Bøtner, Anette; Nielsen, Jens; Oleksiewicz, M.B.

    1999-01-01

    In Denmark, a porcine reproductive and respiratory syndrome virus (PRRSV) control programme, comprising vaccination of seropositive herds with a live American type PRRSV vaccine, was started in 1996. In several of these herds, spread of vaccine virus from vaccinated 3-18 week old pigs to non...... in previously European PRRSV infected pigs after challenge with the vaccine strain seems to be the result of a boosting effect on the immune system, induced by the heterologous vaccine PRRSV strain....

  20. MULTIFRACTAL STRUCTURE OF CENTRAL AND EASTERN EUROPEAN FOREIGN EXCHANGE MARKETS

    Directory of Open Access Journals (Sweden)

    Cn#259;pun#351;an Rn#259;zvan

    2012-07-01

    Full Text Available It is well known that empirical data coming from financial markets, like stock market indices, commodities, interest rates, traded volumes and foreign exchange rates have a multifractal structure. Multifractals were introduced in the field of economics to surpass the shortcomings of classical models like the fractional Brownian motion or GARCH processes. In this paper we investigate the multifractal behavior of Central and Eastern European foreign exchange rates, namely the Czech koruna, Croatian kuna, Hungarian forint, Polish zlot, Romanian leu and Russian rouble with respect to euro from January 13, 2000 to February 29, 2012. The dynamics of exchange rates is of interest for investors and traders, monetary and fiscal authorities, economic agents or policy makers. The exchange rate movements affect the international balance of payments, trade flows, and allocation of the resources in national and international economy. The empirical results from the multifractal detrending fluctuation analysis algorithm show that the six exchange rate series analysed display significant multifractality. Moreover, generating shuffled and surrogate time series, we analyze the sources of multifractality, long-range correlations and heavy-tailed distributions, and we find that this multifractal behavior can be mainly attributed to the latter. Finally, we propose a foreign exchange market inefficiency ranking by considering the multifractality degree as a measure of inefficiency. The regulators, through policy instruments, aim to improve the informational inefficiency of the markets, to reduce the associated risks and to ensure economic stabilization. Evaluation of the degree of information efficiency of foreign exchange markets, for Central and Eastern Europe countries, is important to assess to what extent these countries are prepared for the transition towards fully monetary integration. The weak form efficiency implies that the past exchange rates cannot help to

  1. Detailed genetic structure of European bitterling populations in Central Europe

    Directory of Open Access Journals (Sweden)

    Veronika Bartáková

    2015-11-01

    Full Text Available The European bitterling (Rhodeus amarus is a small cyprinid fish whose populations declined markedly between 1950 and 1980. However, its range currently expands, partly due to human-assisted introductions. We determined the genetic variability and detailed spatial structure among bitterling populations in Central Europe and tested alternative hypotheses about colonization of this area. Twelve polymorphic microsatellite loci on a large sample of 688 individuals had been used to analyse genetic variability and population structure. Samples originated from 27 localities with emphasis on area of the Czech Republic where three major sea drainages (Black, Baltic, and Northern Sea meet. Highly variable level of intrapopulation genetic variability had generally been detected and a recent decrease in numbers (“bottleneck” had been indicated by genetic data among six populations. High level of interpopulation differentiation was identified even within the basins. There was a significant role of genetic drift and indications of low dispersal ability of R. amarus. Surprisingly, the Odra River was inhabited by two distinct populations without any genetic signatures of a secondary contact. Czech part of the Odra (Baltic basin was colonized from the Danubian refugium (similarly to adjacent Danubian basin rivers including the Morava, while Polish part of the Odra was genetically similar to the populations in the Vistula River (Baltic basin, that has been colonized by a different (Eastern phylogeographic lineage of R. amarus. Most Czech R. amarus populations were colonized from the Danubian refugium, suggesting potential for a human-mediated colonization of the Odra or Elbe Rivers by R. amarus. One Elbe basin population was genetically mixed from the two (Danubian and Eastern phylogeographic lineages. In general the Czech populations of R. amarus were genetically stable except for a single population which has probably been recently introduced. This research

  2. Efficacy of rabies vaccines in dogs and cats and protection in a mouse model against European bat lyssavirus type 2.

    Science.gov (United States)

    Nokireki, Tiina; Jakava-Viljanen, Miia; Virtala, Anna-Maija; Sihvonen, Liisa

    2017-10-02

    Rabies is preventable by pre- and/or post-exposure prophylaxis consisting of series of rabies vaccinations and in some cases the use of immunoglobulins. The success of vaccination can be estimated either by measuring virus neutralising antibodies or by challenge experiment. Vaccines based on rabies virus offer cross-protection against other lyssaviruses closely related to rabies virus. The aim was to assess the success of rabies vaccination measured by the antibody response in dogs (n = 10,071) and cats (n = 722), as well as to investigate the factors influencing the response to vaccination when animals failed to reach a rabies antibody titre of ≥ 0.5 IU/ml. Another aim was to assess the level of protection afforded by a commercial veterinary rabies vaccine against intracerebral challenge in mice with European bat lyssavirus type 2 (EBLV-2) and classical rabies virus (RABV), and to compare this with the protection offered by a vaccine for humans. A significantly higher proportion of dogs (10.7%, 95% confidence interval CI 10.1-11.3) than cats (3.5%; 95% CI 2.3-5.0) had a vaccination antibody titre of dogs, vaccination with certain vaccines, vaccination over 6 months prior the time of antibody determination and vaccination of dogs with a size of > 60 cm or larger resulted in a higher risk of failing to reach an antibody level of at least 0.5 IU/ml. When challenged with EBLV-2 and RABV, 80 and 100% of mice vaccinated with the veterinary rabies vaccine survived, respectively. When mice were vaccinated with the human rabies vaccine and challenged with EBLV-2, 75-80% survived, depending on the booster. All vaccinated mice developed sufficient to high titres of virus-neutralising antibodies (VNA) against RABV 21-22 days post-vaccination, ranging from 0.5 to 128 IU/ml. However, there was significant difference between antibody titres after vaccinating once in comparison to vaccinating twice (P dogs and cats in their ability to reach a post vaccination

  3. Determinants in the uptake of the Human Papillomavirus vaccine: a systematic review based on European studies

    Directory of Open Access Journals (Sweden)

    Victoria eFernández de Casadevante

    2015-06-01

    Full Text Available Background Cervical cancer is the fourth most common cancer affecting women worldwide. Since 2006, two Human Papillomavirus vaccines (HPVV have been licensed to protect women against the virus that causes cervical cancer. However, worldwide coverage remains unequal. Studies from the USA found strong evidence for differences in HPVV uptake by ethnicity and healthcare coverage. As the profile of ethnic groups and the healthcare system in the USA differ from countries in Europe where HPVV is free in most of the countries, we conducted a systematic review in order to analyze the determinants of HPVV uptake in Europe.Methods We performed a systematic Pubmed, Scopus and Science Direct search to find articles published from HPVV availability in European countries until April 2014. No age restriction was applied. We included all studies assessing factors associated with HPVV uptake. Uptake refers to either initiation and/or completion of the three dose vaccination program. Results Out of the 23 eligible studies, 14 were retrospective reviews of data, six were cross-sectional surveys and three were prospective cohort studies. Higher HPVV uptake was associated with ethnic majority populations, higher socio-economic status, regular cervical screening participation by the mother and having received previous childhood vaccinations.Conclusions Since the vaccine is offered for free in most of the European countries, the findings suggest that ethno-cultural and educational factors play an important role when it comes to HPVV uptake. Girls who were undervaccinated had also a lower uptake of standard childhood vaccines and mothers who were less likely to attend cervical cancer screening. This may indicate, that only few parents have specific concerns with HPVV, and that preventive health care should seek ways to target these vulnerable groups.

  4. EDITORIAL: The 18th Central European Workshop on Quantum Optics The 18th Central European Workshop on Quantum Optics

    Science.gov (United States)

    Sánchez-Soto, Luis L.; Man'ko, Margarita A.

    2012-02-01

    Much of our present understanding of the microscopic world is based on quantum mechanics. The field owes much of its existence to the venerable science of optics, since the fundamental ideas on the nature of the interaction between light and matter lie at the roots of its origin. We have now reached one century of quantum mechanics. In contrast, the splendid blossoming of quantum optics began only after the comparatively recent invention of the laser. Since then, it has become an exciting and always expanding area at the cutting-edge of research, in part because theory and experiment are more closely connected in this field than any other. Moreover, the technological distance between fundamental studies and practical applications has always been very short in quantum optics. As a result, modern engineering is increasingly based on quantum rather than classical physics; we are facing a transition similar to the one society confronted 200 years ago, at the start of the Industrial Revolution. In parallel with this, the physics community is witnessing the recent and vigorous emergence of quantum information. It aims at exploring the physical foundations of information and at developing efficient methods for processing quantum information. The questions driving this field reveal a profound change in attitude towards fundamental aspects of quantum theory. The photon turns out to be a tool extremely well suited to exploring theoretical quantum information schemes and their experimental implementations. Mirroring this continued progress has been the growth and development of the series of annual Central European Workshops on Quantum Optics (CEWQO). The series started at the beginning of the 1990s, as rather small meetings of physicists from a few countries in central-eastern Europe. In two decades, the workshops have transformed into important events that reach well beyond the original rather restricted geographical limits. The history of CEWQOs can be found in the preface

  5. Comparative Epidemiologic Characteristics of Pertussis in 10 Central and Eastern European Countries, 2000-2013

    Science.gov (United States)

    Heininger, Ulrich; André, Philippe; Chlibek, Roman; Kristufkova, Zuzana; Kutsar, Kuulo; Mangarov, Atanas; Mészner, Zsófia; Nitsch-Osuch, Aneta; Petrović, Vladimir; Prymula, Roman; Usonis, Vytautas; Zavadska, Dace

    2016-01-01

    We undertook an epidemiological survey of the annual incidence of pertussis reported from 2000 to 2013 in ten Central and Eastern European countries to ascertain whether increased pertussis reports in some countries share common underlying drivers or whether there are specific features in each country. The annual incidence of pertussis in the participating countries was obtained from relevant government institutions and/or national surveillance systems. We reviewed the changes in the pertussis incidence rates in each country to explore differences and/or similarities between countries in relation to pertussis surveillance; case definitions for detection and confirmation of pertussis; incidence and number of cases of pertussis by year, overall and by age group; population by year, overall and by age group; pertussis immunization schedule and coverage, and switch from whole-cell pertussis vaccines (wP) to acellular pertussis vaccines (aP). There was heterogeneity in the reported annual incidence rates and trends observed across countries. Reported pertussis incidence rates varied considerably, ranging from 0.01 to 96 per 100,000 population, with the highest rates generally reported in Estonia and the lowest in Hungary and Serbia. The greatest burden appears for the most part in infants (<1 year) in Bulgaria, Hungary, Latvia, Romania, and Serbia, but not in the other participating countries where the burden may have shifted to older children, though surveillance of adults may be inappropriate. There was no consistent pattern associated with the switch from wP to aP vaccines on reported pertussis incidence rates. The heterogeneity in reported data may be related to a number of factors including surveillance system characteristics or capabilities, different case definitions, type of pertussis confirmation tests used, public awareness of the disease, as well as real differences in the magnitude of the disease, or a combination of these factors. Our study highlights the

  6. [The seroprevalence rate, vaccination rate and seroconversion rate of hepatitis A in central region of Korea].

    Science.gov (United States)

    Yun, Seung Wook; Lee, Won Kyung; Cho, Sun Young; Moon, Sung Hoon; Shin, Hyun Deok; Yun, Se Young; Kim, Suk Bae; Shin, Jeong Eun; Kim, Hong Ja; Song, Il Han; Lee, Kun Song; Lee, Jae Hyun

    2011-03-01

    Acute hepatitis A (HAV) is markedly increasing recently on. Some patients with acute hepatitis A show severe clinical course. The seroprevalence rate of IgG anti-HAV has been changing with the regions and the times. Vaccination and seroconversion rate of HAV are not well known. In this study, we aimed to study the difference of seroprevalence rate of IgG anti-HAV according to various clinical factors and to know the vaccination rate and seroconversion rate below 10 years old in the central region of South Korea including Cheonan city. Seven hundred seventy two subjects were included in the study from January to September 2009. We analyzed seroprevalence rate of IgG anti-HAV according to sex, age, region, and other viral markers. We interviewed the history of vaccination(1st, 2nd) and analyzed seroconversion rate according to vaccination time below 10 years old. The total seroprevalence rate of IgG anti-HAV was 65.3%. The seroprevalence rate of IgG anti-HAV rate in 2nd, 3rd, and 4th decade was very low (1.9%, 18.8%, 44.8%). The vaccination rate of children was about 50%. The seroconversion rate after 1st, and 2nd vaccination were 85%, 96%. Catch-up vaccination for teenagers and young adults is needed. Immunizing children with HAV vaccine as a routine schedule should be considered.

  7. Options of biofuel trade from Central and Eastern to Western European countries

    NARCIS (Netherlands)

    van Dam, J.; Faaij, A.P.C.|info:eu-repo/dai/nl/10685903X; Lewandowski, I.M.; Van Zeebroeck, B.

    2009-01-01

    Central and Eastern European countries (CEEC) have a substantial biomass production and export potential. The objective of this study is to assess whether the market for biofuels and trade can be profitable enough to realize a supply of biofuels from the CEEC to the European market and to estimate

  8. The Central European Manufacturin Core: What is Driving Regional Production Sharing?

    OpenAIRE

    Stehrer, Rober; Stöllinger, Roman

    2015-01-01

    There is evidence that Europe's manufacturing activity is increasingly concentrated in a Central European (CE) core which the IMF in a recent publication also refers to as the German-Central European supply chain. This CE manufacturing core is dominated by Germany and in addition comprises Austria and the four Visegrád countries (the Czech Republic, Slovakia, Hungary and Poland). The case of Austria is particularly interesting because it is neither the primary technology leader within the cou...

  9. Cost effectiveness of the new pneumococcal vaccines: a systematic review of European studies.

    Science.gov (United States)

    van de Vooren, Katelijne; Duranti, Silvy; Curto, Alessandro; Garattini, Livio

    2014-01-01

    Diseases caused by Streptococcus pneumoniae (pneumococcus) are a major global public health problem. Despite their importance, information on the burden of the different pneumococcal diseases is limited and estimates vary widely. We critically reviewed the full economic evaluations (FEEs) on the new pneumococcal conjugate vaccines (PCVs) conducted in the European Union (EU) to assess their potential contribution to public decision making. We selected the FEEs focussed on PCV-10 and PCV-13 and published in English from January 2007 until June 2013. We screened the selected articles to assess their main methodological features using a common checklist composed of epidemiological, clinical and economic items. All the ten studies selected were based on modelling and the time horizon was always long term. Two studies focused on adults, the remaining eight on infants. Only one study based herd immunity on national data, eight used foreign data or modelling and the last did not consider it. National prices and tariffs were claimed to be sources for unit costs in all studies; however, half of them assumed price parity when one vaccine was not yet marketed, and the figures varied within the countries where more than one study was conducted. Conclusions supported the economic utility of pneumococcal vaccination in all studies, raising some concern only in (i) the independent study, which found that PCV-13 was borderline cost effective, and (ii) the study sponsored by both manufacturers, which estimated an incremental ratio slightly above the national threshold for both PCV-10 and PCV-13. The European studies we analysed are mostly based on weak sources of data. Because of the limited information on vaccine effectiveness and lack of epidemiological and economic data, the need for extensive recourse to assumptions leads to great within- and between-study variability generated by authors' choices.

  10. UNCONVENTIONAL MONETARY POLICY: CHANGING EUROPEAN CENTRAL BANK’S PERSPECTIVE ON FINANCIAL GOVERNANCE

    Directory of Open Access Journals (Sweden)

    Bogdan Munteanu

    2017-06-01

    Full Text Available The paper aims to look at the European Central Bank governance in terms of decisions taken to deploy a new kit of unconventional monetary policy measures, in order to respond to a new economic paradigm characterized by dynamic change in evolution, high volatility and enhanced financial risks. As an institution, the European Central Bank is led by the Governing Council and the decisions taken on how to use monetary policy impact an entire financial system. European Central Banking governance is about safeguarding the common currency and ensuring a future for the economic and monetary area to emerge stronger. For this purpose, when conventional monetary policies reach limits in their effects, it is time for the European Central Bank governance to analyse and assume the decision to deploy the arsenal of unconventional monetary policies. The experience of recent years showed a positive effect of the European Central Bank’s unconventional monetary measures, but costs could rise in case of extensive use of such measures. When these measures are used in combination, the effect is amplified and the European Central Bank needs to assess when it is time to withdraw the support, how to communicate and what exit strategy should use, what the costs are and impact can expect.

  11. The synergistic role TQM and reengineering could play in standardizing the European vaccination policy.

    Science.gov (United States)

    Dubois, Hans F W

    2002-01-01

    For the implementation of the proposed European standardized vaccination, total quality management (TQM) and reengineering could be powerful tools with a potentially synergistic effect. In the case examined, nonexplicit TQM prepared the organization in several ways for reengineering: providing the human capital, making people think beyond their daily tasks, and pulling the inertial professional organization in the direction of an "adhocracy." The quiet role management played, the incentive supplied by a high authority, the quick creation of solutions, and the existence of a realistic crisis represent other success factors.

  12. Forming Professional Competency of Education Managers in Central European Countries

    Science.gov (United States)

    Tovkanets, Oksana

    2017-01-01

    The article deals with the problem of forming education managers' professional competency in the context of European integration educational processes. The peculiarities of education managers' competences as well as directions of their professional training in motivational, cognitive and metacognitive spheres have been theoretically justified. The…

  13. Vaccinations in migrants and refugees: a challenge for European health systems. A systematic review of current scientific evidence.

    Science.gov (United States)

    Mipatrini, Daniele; Stefanelli, Paola; Severoni, Santino; Rezza, Giovanni

    2017-03-01

    The decline of immunization rates in countries of origin of migrants and refugees, along with risky conditions during the journey to Europe, may threaten migrants' health. We performed a systematic review of the scientific literature in order to assess the frequency of vaccine preventable diseases, and vaccination coverage among migrants and refugees in Europe. To this end, Medline and Cochrane databases were considered. After the screening and the selection process, 58 papers were included in the review. We focused on the following vaccine-preventable diseases: hepatitis B, measles, rubella, mumps, tetanus, poliomyelitis, pertussis, diphtheria, meningitis, and varicella. The results were presented as a qualitative synthesis. In summary, several studies highlighted that migrants and refugees have lower immunization rates compared to European-born individuals. Firstly, this is due to low vaccination coverage in the country of origin. Then, several problems may limit migrants' access to vaccination in Europe: (i) migrants are used to move around the continent, and many vaccines require multiple doses at regular times; (ii) information on the immunization status of migrants is often lacking; (iii) hosting countries face severe economic crises; (iv) migrants often refuse registration with medical authorities for fear of legal consequences and (v) the lack of coordination among public health authorities of neighboring countries may determine either duplications or lack of vaccine administration. Possible strategies to overcome these problems include tailoring immunization services on the specific needs of the target population, developing strong communication campaigns, developing vaccination registers, and promoting collaboration among public health authorities of European Countries.

  14. Europeanization in making policies against domestic violence in Central and Eastern Europe.

    Science.gov (United States)

    Krizsan, Andrea; Popa, Raluca

    2010-01-01

    This article looks at how Europe matters in the development of policies against domestic violence, a gender equality field outside the core European Union (EU) conditionality criteria. By analyzing the concrete workings and uses of Europe's domestic violence policy-making in five Central and Eastern European countries, it identifies three mechanisms of Europeanization in the field and shows how together they work to expand the reach of the EU to this policy realm. The findings point toward an understanding of Europeanization based on social learning and dynamic, interactive processes of constructing what membership in the EU means in terms of domestic violence policy processes.

  15. Emergence of sandflies (Phlebotominae) in Austria, a Central European country

    OpenAIRE

    Poeppl, Wolfgang; Obwaller, Adelheid G.; Weiler, Martin; Burgmann, Heinz; Mooseder, Gerhard; Lorentz, Susanne; Rauchenwald, Friedrich; Aspöck, Horst; Walochnik, Julia; Naucke, Torsten J

    2013-01-01

    The possible existence of autochthonous sandfly populations in Central Europe north of the Alps has long been excluded. However, in the past years, sandflies have been documented in Germany, Belgium, and recently, also in Austria, close to the Slovenian border. Moreover, autochthonous human Leishmania and Phlebovirus infections have been reported in Central Europe, particularly in Germany. From 2010 to 2012, sandfly trapping (740 trap nights) was performed at 53 different capture sites in Aus...

  16. Antonio Porta and Seventeenth-Century Central European Architecture

    OpenAIRE

    Krummholz, Martin

    2015-01-01

    The text places the work of Antonio Porta (1631/32-1702) in the broader context of European architecture. It emphasises the close connections between Porta's architecture and the work of Francesco Caratti and Jean Baptiste Mathey, and the common starting-point for these artists, which was the Viennese architecture of Filiberto Lucchese and Giovanni Pietro Tencalla. The architecture of the Troja chateau of Count Sternberg can also be interpreted in this context; it draws on the analogous subur...

  17. Evolving Privatization in Eastern and Central European Higher Education

    Science.gov (United States)

    Levy, Daniel

    2014-01-01

    With the fall of communism in 1989, Eastern and Central Europe would quickly become part of an already strong global tide of privatization in higher education. Nowhere else did private higher education rise so suddenly or strongly from virtual nonexistence to a major regional presence. A fresh database allows us to analyze the extent and…

  18. A step forward in the quality control testing of inactivated rabies vaccines - extensive evaluation of European vaccines by using alternative methods to the in vivo potency tests.

    Science.gov (United States)

    Servat, Alexandre; Kempff, Sébastien; Brogat, Valère; Litaize, Estelle; Schereffer, Jean-Luc; Cliquet, Florence

    2015-03-01

    The mouse challenge test still remains the reference method for the potency determination of human and animal inactivated rabies vaccines, and it is still widely used throughout the world. This test suffers from many disadvantages - it is expensive and time consuming, uses a large number of mice, causes significant animal distress, and suffers from high variability. Recently, the European Pharmacopoeia has recognised the use of a serological potency assay (SPA) as an alternative method to the challenge test. This new test is based on the determination of rabies neutralising antibody titres in vaccinated mice, by using the modified Rapid Fluorescent Focus Inhibition Test (mRFFIT). With the objective of adopting this new method for the batch release of inactivated rabies vaccines, we evaluated its performance on a large collection of rabies vaccines currently assessed in our laboratory. The Fluorescent Antibody Virus Neutralisation test (FAVNt) was used in parallel with the mRFFIT, and the results were compared to the mouse challenge test. Our results demonstrate that the SPA is capable of estimating the potency of vaccines formulated with a potency margin well above the minimum of 1IU/dose. For low potency vaccines, this new method demonstrated some limitations, due to the recurrent invalidation of the assay. We have also demonstrated the superior sensitivity of the FAVNt when compared to the mRFFIT, and the importance of minimising the risk of detecting non-responders in vaccinated mice. 2015 FRAME.

  19. Upgrading technology in Central and Eastern European economies

    OpenAIRE

    RADOSEVIC Slavo

    2017-01-01

    The future growth of Central and Eastern Europe (CEE) depends on upgrading technology, exporting and coupling domestic technology efforts while improving their position in global value chains. Current policies in the region are not geared to these tasks, despite the availability of huge financial opportunities in the form of EU structural funds. Existing policies are overly focused on research and development (R&D) and neglect sources of productivity growth, such as management practices, skil...

  20. Psychoanalysis and the Emigration of Central and Eastern European Intellectuals.

    Science.gov (United States)

    Erős, Ferenc

    2016-12-01

    One of the most important phenomena in the intellectual history of the 20th century was the exodus of the European mind, the emigration of persons, ideas, techniques, and institutions in the vast areas of social, human, and natural sciences, as well as in literature and the visual arts. Among these exiled intellectuals, psychoanalysts formed a special group. This paper examines the major lines of the emigration of psychoanalysts from the countries of issue to the countries of reception. It focuses, in particular on Hungarian analysts and analytic candidates who left their country of birth in two waves, first after the failure of revolutions in 1918/19 for Berlin, and then after 1938, to escape the Nazis. The paper comments on the existential situation of émigré psychoanalysts in light of Hannah Arendt's writings on refugees.

  1. INTERGEO - Central/East European Collaboration Network on direct application of geothermal energy

    Energy Technology Data Exchange (ETDEWEB)

    Popovski, K. [Central/East European Collaboration Network on Direct Application of Geothermal Energy, Bitola (Yugoslavia); Arpasi, M. [International Geothermal Association - European Branch, Budapest (Hungary)

    1997-12-01

    A proposal for organisation of a Network to be known as INTERGEO is presented, which should extend and reinforce the cooperation for the development of the direct application of geothermal energy between the developed EC countries and the ones of the so called Central/East European region. Unter the term `developed countries` for this particular energy source utilisation mainly Italy, France and Germany should be understood. The Central/East European region consists the following countries: Albania, Bosnia and Herzegovina, Bulgaria, Belarus, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lituania, Macedonia, Moldova, Poland, Roumania, Slovenia, Slovakia, Turkey, Ukraine and Yugoslavia. The idea itself, the need and possibilities for organisation, possible plan of action and expected benefits for the EC and Central/East European countries are elaborated in order to come to the conclusions for the proposal justifiableness and feasibility for realisation. (orig.)

  2. Emergence of sandflies (Phlebotominae) in Austria, a Central European country.

    Science.gov (United States)

    Poeppl, Wolfgang; Obwaller, Adelheid G; Weiler, Martin; Burgmann, Heinz; Mooseder, Gerhard; Lorentz, Susanne; Rauchenwald, Friedrich; Aspöck, Horst; Walochnik, Julia; Naucke, Torsten J

    2013-12-01

    The possible existence of autochthonous sandfly populations in Central Europe north of the Alps has long been excluded. However, in the past years, sandflies have been documented in Germany, Belgium, and recently, also in Austria, close to the Slovenian border. Moreover, autochthonous human Leishmania and Phlebovirus infections have been reported in Central Europe, particularly in Germany. From 2010 to 2012, sandfly trapping (740 trap nights) was performed at 53 different capture sites in Austria using battery-operated CDC miniature light traps. Sites were chosen on the basis of their climate profile in the federal states Styria, Burgenland, and Lower Austria. Sandfly specimens found were transferred to 70% ethanol for conservation. Identification was based on morphological characters of the male genitalia and the female spermathecae, respectively. Altogether, 24 specimens, 22 females and 2 males, all identified as Phlebotomus (Transphlebotomus) mascittii Grassi, 1908, were found at six different sampling sites in all three federal states investigated. The highest number of catches was made on a farm in Lower Austria. Altogether, the period of sandfly activity in Austria was shown to be much longer than presumed, the earliest capture was made on July 3rd and the latest on August 28th. Sandflies have been autochthonous in Austria in small foci probably for long, but in the course of global warming, further spreading may be expected. Although P. mascittii is only an assumed vector of Leishmania spp.-data on its experimental transmission capacity are still lacking-the wide distribution of sandflies in Austria, a country thought to be free of sandflies, further supports a potential emergence of sandflies in Central Europe. This is of medical relevance, not only with respect to the transmission of Leishmania spp. for which a reservoir is given in dogs, but also with respect to the phleboviruses.

  3. Atmospheric processes triggering the central European floods in June 2013

    Science.gov (United States)

    Grams, C. M.; Binder, H.; Pfahl, S.; Piaget, N.; Wernli, H.

    2014-07-01

    In June 2013, central Europe was hit by a century flood affecting the Danube and Elbe catchments after a 4 day period of heavy precipitation and causing severe human and economic loss. In this study model analysis and observational data are investigated to reveal the key atmospheric processes that caused the heavy precipitation event. The period preceding the flood was characterised by a weather regime associated with cool and unusual wet conditions resulting from repeated Rossby wave breaking (RWB). During the event a single RWB established a reversed baroclinicity in the low to mid-troposphere in central Europe with cool air trapped over the Alps and warmer air to the north. The upper-level cut-off resulting from the RWB instigated three consecutive cyclones in eastern Europe that unusually tracked westward during the days of heavy precipitation. Continuous large-scale slantwise ascent in so-called "equatorward ascending" warm conveyor belts (WCBs) associated with these cyclones is found as the key process that caused the 4 day heavy precipitation period. Fed by moisture sources from continental evapotranspiration, these WCBs unusually ascended equatorward along the southward sloping moist isentropes. Although "equatorward ascending" WCBs are climatologically rare events, they have great potential for causing high impact weather.

  4. Atmospheric processes triggering the central European floods in June 2013

    Directory of Open Access Journals (Sweden)

    C. M. Grams

    2014-07-01

    Full Text Available In June 2013, central Europe was hit by a century flood affecting the Danube and Elbe catchments after a 4 day period of heavy precipitation and causing severe human and economic loss. In this study model analysis and observational data are investigated to reveal the key atmospheric processes that caused the heavy precipitation event. The period preceding the flood was characterised by a weather regime associated with cool and unusual wet conditions resulting from repeated Rossby wave breaking (RWB. During the event a single RWB established a reversed baroclinicity in the low to mid-troposphere in central Europe with cool air trapped over the Alps and warmer air to the north. The upper-level cut-off resulting from the RWB instigated three consecutive cyclones in eastern Europe that unusually tracked westward during the days of heavy precipitation. Continuous large-scale slantwise ascent in so-called "equatorward ascending" warm conveyor belts (WCBs associated with these cyclones is found as the key process that caused the 4 day heavy precipitation period. Fed by moisture sources from continental evapotranspiration, these WCBs unusually ascended equatorward along the southward sloping moist isentropes. Although "equatorward ascending" WCBs are climatologically rare events, they have great potential for causing high impact weather.

  5. Willingness of European healthcare workers to undergo vaccination against seasonal influenza: current situation and suggestions for improvement

    Directory of Open Access Journals (Sweden)

    George Kassianos

    2015-01-01

    Full Text Available Uptake of vaccination against seasonal influenza in healthcare workers (HCWs is, in general, low (vaccine coverage of 6–54%, as is awareness of its importance, and has been decreasing in most European Union (EU countries in recent years. By virtue of their working environment, HCWs are at an increased risk of influenza infection and of subsequently transmitting the virus to vulnerable patients, in whom disease burden is significant. It could be argued that a similar or higher target vaccination rate to that recommended for older age groups and people with chronic medical conditions (75% should be applied to HCWs, and the European Council recommends Member States to improve vaccination coverage in this population. In this context, better education of HCWs is needed to increase awareness and highlight the importance of HCW vaccination for the benefit of public health, particularly for their patients, who may be at risk of serious complications that could lead to disability or death. Secondary to these professional responsibilities, personal benefits (as well as benefits to close family and friends should also be emphasised. Misconceptions that create barriers to vaccination need to be discussed openly and objections placed in the context of public health.

  6. Influenza Vaccine Research funded by the European Commission FP7-Health-2013-Innovation-1 project

    NARCIS (Netherlands)

    Liu, Heng; Frijlink, Henderik W.; Huckriede, Anke; van Doorn, Eva; Schmidt, Ed; Leroy, Odile; Rimmelzwaan, Guus; McCullough, Keneth; Whelan, Mike; Hak, Eelko

    2016-01-01

    Due to influenza viruses continuously displaying antigenic variation, current seasonal influenza vaccines must be updated annually to include the latest predicted strains. Despite all the efforts put into vaccine strain selection, vaccine production, testing, and administration, the protective

  7. Herrscherschaft and herrschersuffix in Central-East European languages

    Directory of Open Access Journals (Sweden)

    Sorin Paliga

    2002-12-01

    Full Text Available The paper resumes a topic the author approached in severa[ instances beginning with 1987: some specific terms referring to the semantic sphere Herrscherschafi. In Romanian, ban, jupîn, stăpîn and probably also cioban reflect the indigenous Thracian substratum; these forms also reflect the archaic Indo-European Herrschersujfzx -n-. In Slavic, their equivalent forms ban, župan and stopan reflect either a Late Thracian or (Proto-Romanian influence. Equally Rom. vătaf reflects the substratum influence, whereas Slavic vatah, vatak, vataš reflects the same borrowing. On the other hand, Slavic gospodƄ, belongs to the archaic Proto-Slavic core elements, while cěsaŕƄ, reflect a Germanic influence. Finally, Rom. boier is an East-Romance innovation derived from bou 'ox' and initially meant 'owner of cattle = rich man', a traditional association between cattle-owners and richness. The word had a large distribution from the early Middle Ages until late in the 20th century. In a paper written some 15 years ago (Paliga 1987, in Linguistica, Ljubljana 1 dared suggest that a series of Romanian and Slavic terms referring to social and political organisation, specifically ban (1 'master, local leader' and (2 'coin, money' (2nd sense derived from the lst one,jupîn (formerly giupîn 'a master', 'a master, a lord', cioban 'a shepherd', rather reflect a compact etymological group of Pre-Romance and Pre-Slavic origin (including cioban, incorrectly considered a Turkish influence, seemingly starting from the erroneous, but largely spread hypothesis that intervocalic -b- in Romanian would rather suggest a newer origin 1 . To these, on another occasion, I added the form vătaf,vătah (also with parallels in some Slavic languages, Paliga 1996: 34-36 and on another occasion 1 analysed the form boier, also spread in many neighbouring languages, which has often been considered either of unknown origin or again of Turkic (not Turkish, i.e. Ottoman origin (Paliga 1990

  8. Central and Eastern European Social Policy and European Union Accession: Time for Reform

    Directory of Open Access Journals (Sweden)

    Noemi Lendvai

    2005-03-01

    Full Text Available European Union enlargement and accession are reflexive of both EU and post-communist social policies. There is a unique “dialogue“ going on, indicative of fundamental aspects of post-communist, post-transitional social policy. It is also a 'mirror' that reflects shortcomings of governance, and often presents a neglected institutional landscape. Therefore, the Europeanisation of social policy is an essential transformation process for post-communist countries whereby a new language and new concepts are introduced, the outlines of new social-policy governance emerge and enter the space in which social policy is formulated and considered.

  9. Landslide hazards and systems analysis: A Central European perspective

    Science.gov (United States)

    Klose, Martin; Damm, Bodo; Kreuzer, Thomas

    2016-04-01

    Part of the problem with assessing landslide hazards is to understand the variable settings in which they occur. There is growing consensus that hazard assessments require integrated approaches that take account of the coupled human-environment system. Here we provide a synthesis of societal exposure and vulnerability to landslide hazards, review innovative approaches to hazard identification, and lay a focus on hazard assessment, while presenting the results of historical case studies and a landslide time series for Germany. The findings add to a growing body of literature that recognizes societal exposure and vulnerability as a complex system of hazard interactions that evolves over time as a function of social change and development. We therefore propose to expand hazard assessments by the framework and concepts of systems analysis (e.g., Liu et al., 2007) Results so far have been promising in ways that illustrate the importance of feedbacks, thresholds, surprises, and time lags in the evolution of landslide hazard and risk. In densely populated areas of Central Europe, landslides often occur in urbanized landscapes or on engineered slopes that had been transformed or created intentionally by human activity, sometimes even centuries ago. The example of Germany enables to correlate the causes and effects of recent landslides with the historical transition of urbanization to urban sprawl, ongoing demographic change, and some chronic problems of industrialized countries today, including ageing infrastructures or rising government debts. In large parts of rural Germany, the combination of ageing infrastructures, population loss, and increasing budget deficits starts to erode historical resilience gains, which brings especially small communities to a tipping point in their efforts to risk reduction. While struggling with budget deficits and demographic change, these communities are required to maintain ageing infrastructures that are particularly vulnerable to

  10. Characterization and efficacy determination of commercially available Central American H5N2 avian influenza vaccines for poultry

    Science.gov (United States)

    A poultry vaccination program was implemented in Central America beginning in January 1995 to control both H5N2 low (LPAI) and high pathogenicity avian influenza. This study was conducted to identify seed strain composition and the efficacy of nine commercially available H5 vaccines against challen...

  11. Effects of atmospheric and climate change at the timberline of the Central European Alps

    Science.gov (United States)

    Wieser, Gerhard; Matyssek, Rainer; Luzian, Roland; Zwerger, Peter; Pindur, Peter; Oberhuber, Walter; Gruber, Andreas

    2011-01-01

    This review considers potential effects of atmospheric change and climate warming within the timberline ecotone of the Central European Alps. After focusing on the impacts of ozone (O3) and rising atmospheric CO2 concentration, effects of climate warming on the carbon and water balance of timberline trees and forests will be outlined towards conclusions about changes in tree growth and treeline dynamics. Presently, ambient ground-level O3 concentrations do not exert crucial stress on adult conifers at the timberline of the Central European Alps. In response to elevated atmospheric CO2 Larix decidua showed growth increase, whereas no such response was found in Pinus uncinata. Overall climate warming appears as the factor responsible for the observed growth stimulation of timberline trees. Increased seedling re-establishment in the Central European Alps however, resulted from invasion into potential habitats rather than upward migration due to climate change, although seedlings will only reach tree size upon successful coupling with the atmosphere and thus loosing the beneficial microclimate of low stature vegetation. In conclusion, future climate extremes are more likely than the gradual temperature increase to control treeline dynamics in the Central European Alps. PMID:21379395

  12. Land banking and Central Europe : future relevance, current initiatives, Western European past experience

    NARCIS (Netherlands)

    van Dijk, T; Kopeva, D

    Central European agricultural land ownership is fragmented. An instrument that is particularly suited for solving the land fragmentation problem is land banking. Although the potential of land banking is acknowledged, details on the actual use prove to be hard to fill in. In Western Europe, a

  13. Land banking and Central Europe: future relevance, current initiatives, Western European past experience

    NARCIS (Netherlands)

    Dijk, van T.; Kopeva, D.

    2006-01-01

    Central European agricultural land ownership is fragmented. An instrument that is particularly suited for solving the land fragmentation problem is land banking. Although the potential of land banking is acknowledged, details on the actual use prove to be hard to fill in. In Western Europe, a

  14. Reasons for Discontinuing Hashish Use in a Group of Central European Athletes.

    Science.gov (United States)

    Duncan, David F.

    1988-01-01

    Examined self-reported reasons for discontinuing marijuana use among 61 former marijuana using students at central European sports training facility. Most common reasons given for discontinuing marijuana use were dislike of effects, athletic training regimen, health reasons, and mental/emotional problems. (Author/NB)

  15. Guest editorial: Heteropolitanization: social and spatial change in Central and East European cities

    NARCIS (Netherlands)

    Gentile, M.; Tammaru, T.; Kempen, R. van

    2012-01-01

    With more than 20 years of European post-socialist transition behind us, research on the cities of Central and Eastern Europe (CEE) has yet to be situated in contemporary urban theory. Placed within a context of growing research interest on CEE cities, this theme issue on Heteropolitanization:

  16. The challenges of attracting an retaining academic talent. Central and Eastern European perspectives

    NARCIS (Netherlands)

    Leisyte, Liudvika; Rose, Anna-Lena

    2016-01-01

    Central and Eastern European (CEE) countries are currently facing strong imperatives to increase incoming academic staff mobility. In this article, we focus on barriers and facilitators of academic mobility. We provide examples of Lithuanian and Czech higher education systems that are based on

  17. The Central European, Tarim and Siberian Large Igneous Provinces, Late Palaeozoic orogeny and coeval metallogeny

    NARCIS (Netherlands)

    de Boorder, H.|info:eu-repo/dai/nl/098199056

    2014-01-01

    The formation of the Central European and Tarim Large Igneous Provinces (LIPs) in the Early Permian coincided with the demise of the Variscan and the Southern Tianshan orogens, respectively. The Early Triassic Siberian LIP was formed in the wake of the Western Altaid orogeny in the Late Permian.

  18. The democratic accountability of the European Central Bank : A comment on two fairy-tales

    NARCIS (Netherlands)

    De Haan, J; Eijffinger, SCW

    The European Central Bank (ECB) is widely considered to be (legally) independent. Buiter (1999) critizes the ECB for its lack of democratic accountability, which he does not define in a very precise way. Issing (1999) replies to some of the points raised by Buiter and argues that the ECB is both

  19. RE-EXAMINATION OF THE PURCHASING POWER PARITY IN CENTRAL AND EASTERN EUROPEAN ECONOMIES

    Directory of Open Access Journals (Sweden)

    Ahmad Zubaidi Baharumshah

    2011-02-01

    Full Text Available The empirical record on PPP tests for transition economies is far from being so opulent as it is for the developed market economies. This paper attempts to fill this gap by scrutinizing the theory of PPP on a sample of Central and Eastern European economies. The paper has two main advances with respect to previous PPP studies. First, it employs a monthly data base on real exchange rates for a panel of 12 Central and Eastern European economies by testing the theory separately with respect to US dollar and with respect to Euro. Second, we utilise a panel unit root test that involves the estimation of the ADF regression in a SUR framework. Since our study found support for the validity of PPP in some reforming European economies, special attention should be devoted to individual country-specific factors that cause PPP deviations.

  20. Modeling the impact of vaccination control strategies on a foot and mouth disease outbreak in the Central United States.

    Science.gov (United States)

    McReynolds, Sara W; Sanderson, Michael W; Reeves, Aaron; Hill, Ashley E

    2014-12-01

    The central United States (U.S.) has a large livestock population including cattle, swine, sheep and goats. Simulation models were developed to assess the impact of livestock herd types and vaccination on foot and mouth disease (FMD) outbreaks using the North American Animal Disease Spread Model. In this study, potential FMD virus outbreaks in the central region of the U.S. were simulated to compare different vaccination strategies to a depopulation only scenario. Based on data from the U.S. Department of Agriculture National Agricultural Statistics Service, a simulated population of 151,620 livestock operations characterized by latitude and longitude, production type, and herd size was generated. For the simulations, a single 17,000 head feedlot was selected as the initial latently infected herd in an otherwise susceptible population. Direct and indirect contact rates between herds were based on survey data of livestock producers in Kansas and Colorado. Control methods included ring vaccination around infected herds. Feedlots ≥3000 head were either the only production type that was vaccinated or were assigned the highest vaccination priority. Simulated vaccination scenarios included low and high vaccine capacity, vaccination zones of 10 km or 50 km around detected infected premises, and vaccination trigger of 10 or 100 detected infected herds. Probability of transmission following indirect contact, movement controls and contact rate parameters were considered uncertain and so were the subjects of sensitivity analysis. All vaccination scenarios decreased number of herds depopulated but not all decreased outbreak duration. Increased size of the vaccination zone during an outbreak decreased the length of the outbreak and number of herds destroyed. Increased size of the vaccination zone primarily resulted in vaccinating feedlots ≥3000 head across a larger area. Increasing the vaccination capacity had a smaller impact on the outbreak and may not be feasible if

  1. Medical and economic burden of influenza in the elderly population in central and eastern European countries.

    Science.gov (United States)

    Kovács, Gábor; Kaló, Zoltán; Jahnz-Rozyk, Karina; Kyncl, Jan; Csohan, Agnes; Pistol, Adriana; Leleka, Mariya; Kipshakbaev, Rafail; Durand, Laure; Macabeo, Bérengère

    2014-01-01

    Influenza affects 5-15% of the population during an epidemic. In Western Europe, vaccination of at-risk groups forms the cornerstone of influenza prevention. However, vaccination coverage of the elderly (> 65 y) is often low in Central and Eastern Europe (CEE); potentially because a paucity of country-specific data limits evidence-based policy making. Therefore the medical and economic burden of influenza were estimated in elderly populations in the Czech Republic, Hungary, Kazakhstan, Poland, Romania, and Ukraine. Data covering national influenza vaccination policies, surveillance and reporting, healthcare costs, populations, and epidemiology were obtained via literature review, open-access websites and databases, and interviews with experts. A simplified model of patient treatment flow incorporating cost, population, and incidence/prevalence data was used to calculate the influenza burden per country. In the elderly, influenza represented a large burden on the assessed healthcare systems, with yearly excess hospitalization rates of ~30/100,000. Burden varied between countries and was likely influenced by population size, surveillance system, healthcare provision, and vaccine coverage. The greatest burden was found in Poland, where direct costs were over EUR 5 million. Substantial differences in data availability and quality were identified, and to fully quantify the burden of influenza in CEE, influenza reporting systems should be standardized. This study most probably underestimates the real burden of influenza, however the public health problem is recognized worldwide, and will further increase with population aging. Extending influenza vaccination of the elderly may be a cost-effective way to reduce the burden of influenza in CEE.

  2. Effects of vaccination against viral haemorrhagic disease and myxomatosis on long-term mortality rates of European wild rabbits.

    Science.gov (United States)

    Calvete, C; Estrada, R; Lucientes, J; Osacar, J J; Villafuerte, R

    2004-09-25

    The effects of vaccination against myxomatosis and viral haemorrhagic disease (VHD) on long-term mortality rates in European rabbits (Oryctolagus cuniculus) were studied from 1993 to 1996 by radiotracking a free-living population of wild rabbits. During the three months after immunisation, unvaccinated young rabbits weighing between 180 and 600 g were 13.6 times more likely to die than vaccinated young rabbits. In adult rabbits, vaccination did not significantly decrease mortality, mainly owing to the high proportion of rabbits which had previously been exposed to the antigens of both diseases. Compared with adult rabbits with natural antibodies to VHD, rabbits without these antibodies were 5.2 times more likely to die of VHD during annual outbreaks.

  3. [Plans for the establishment of central vaccination committees in the institutionalization of Medicine in Colombia].

    Science.gov (United States)

    Frias Nuñez, M

    1993-01-01

    The fight against smallpox epidemics in the Granada at the end of the 18th and beginning of the 19th centuries involved a whole series of actions which demonstrated the new ways of treating the disease. First the application of the innoculation and then the vaccination coincided with a greater general concern for the health of the population. At this time and especially with the arrival of José Celestino Mutis on Latin-American soil science in Colombia embarked upon an institutionalization process which also involved Medicine. José Salvany's proposals of stablishing Central Vaccination Committees were made in this context. The analysis of these proposals and their contribution towards "establishing institutional spaces" are the axes upon which this study is based.

  4. Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks : A Consensus Framework from a European Vaccine Economics Community

    NARCIS (Netherlands)

    Ultsch, Bernhard; Damm, Oliver; Beutels, Philippe; Bilcke, Joke; Brueggenjuergen, Bernd; Gerber-Grote, Andreas; Greiner, Wolfgang; Hanquet, Germaine; Hutubessy, Raymond; Jit, Mark; Knol, Mirjam; von Kries, Ruediger; Kuhlmann, Alexander; Levy-Bruhl, Daniel; Perleth, Matthias; Postma, Maarten; Salo, Heini; Siebert, Uwe; Wasem, Jurgen; Wichmann, Ole

    Incremental cost-effectiveness and cost-utility analyses [health economic evaluations (HEEs)] of vaccines are routinely considered in decision making on immunization in various industrialized countries. While guidelines advocating more standardization of such HEEs (mainly for curative drugs) exist,

  5. ECONOMIC CONSEQUENCES OF PUBLIC DEBT. THE CASE OF CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Irina BILAN

    2015-10-01

    Full Text Available The paper aims to empirically assess, using panel data estimation techniques, the effects of public indebtedness on economic growth for a group of 11 Central and Eastern European countries and over the period 1994-2013. Our hypothesis is that, although public indebtedness may fuel economic growth, once public debt breaches a certain threshold the effects are reversed and public indebtedness negatively affects GDP growth rates. The results of our study confirm this kind of relationship, with a maximum debt threshold for all countries of about 45-55% of GDP, lower for the less developed (like Romania and Bulgaria and higher for the more developed ones. Also, the threshold for Central and Eastern European countries is found to be lower than the one identified in other empirical studies for developed EU countries, as the former enjoy lower credibility, higher vulnerability to shocks and depend more on external capital transfers.

  6. European guidelines for quality assurance in cervical cancer screening. Summary of the supplements on HPV screening and vaccination

    Directory of Open Access Journals (Sweden)

    Lawrence von Karsa

    2015-12-01

    Full Text Available In a project coordinated by the International Agency for Research on Cancer (IARC 31 experts from 11 European countries and IARC have developed supplements to the current European guidelines for quality assurance in cervical cancer screening. The supplements take into account the potential of primary testing for human papillomavirus (HPV and vaccination against HPV infection to improve cervical cancer prevention and control and will be published by the European Commission in book format. They include 62 recommendations or conclusions for which the strength of the evidence and the respective recommendations is graded. While acknowledging the available evidence for more efficacious screening using HPV primary testing compared to screening based on cytology, the authors and editors of the supplements emphasize that appropriate policy and programme organization remain essential to achieve an acceptable balance between benefit and harm of any screening or vaccination programme. A summary of the supplements and all of the graded recommendations are presented here in journal format to make key aspects of the updated and expanded guidelines known to a wider professional and scientific community. Keywords: Mass screening, Vaccination, Cervical neoplasms, Human papillomavirus, Evidence-based guidelines, Population-based programme

  7. The Determinants of FDI in the Central and Eastern Europe: The Impact of the European Integration

    Directory of Open Access Journals (Sweden)

    Hanna Makhavikova

    2015-05-01

    Full Text Available The amount of FDI inflows to the Central and Eastern Europe increased dramatically during the last two decades. This article is aimed at identifying the ability of the Central Eastern European countries to attract FDI in the context of European integration, and at estimating the most important factors that influence the decision of foreign investors to invest in the region. Despite the broad research has been devoted to define the FDI determinants, the literature dealing in particular with the role of the European Union in the mobilization of FDI is rather scarce, and these findings are very discrepant. In order to understand factors that influence the location of FDI, we employ an empirical model for the period of 1992-2013 for twenty CEE countries. This study reveals that the most important determinants of FDI in CEECs are the market size, cost of labor and the European integration. The results of the research can be used to estimate the effect on FDI inflows from a prospective additional Eastern expansion of the EU by the countries currently not within the EU.

  8. A BiomeBGC-based Evaluation of Dryness Stress of Central European Forests

    OpenAIRE

    Buddenbaum, H.; Hientgen, J.; Dotzler, S.; Werner, W.; Hill, J.

    2015-01-01

    Dryness stress is expected to become a more common problem in central European forests due to the predicted regional climate change. Forest management has to adapt to climate change in time and think ahead several decades in decisions on which tree species to plant at which locations. The summer of 2003 was the most severe dryness event in recent time, but more periods like this are expected. Since forests on different sites react quite differently to drought conditions, we used the ...

  9. Central European MetEor NeTwork: Current status and future activities

    Science.gov (United States)

    Srba, J.; Koukal, J.; Ferus, M.; Lenža, L.; Gorková, S.; Civiš, S.; Simon, J.; Csorgei, T.; Jedlièka, M.; Korec, M.; Kaniansky, S.; Polák, J.; Spurný, M.; Brázdil, T.; Mäsiar, J.; Zima, M.; Delinèák, P.; Popek, M.; Bahýl, V.; Piffl, R.; Èechmánek, M.

    2016-06-01

    The Central European video Meteor Network (CEMeNt) established in 2010 is a platform for cross-border cooperation in the field of video meteor observations between Czech Republic and Slovakia. During five years of operation the CEMeNt network went through an extensive development. In total, 37 video systems were working on 20 permanent stations located in Czech Republic and Slovakia during 2015. In this paper we summarize CEMeNt current status and introduce some future activities.

  10. Changes in Inflation Dynamics under Inflation Targeting? Evidence from Central European Countries

    Czech Academy of Sciences Publication Activity Database

    Baxa, Jaromír; Plašil, M.; Vašíček, B.

    2015-01-01

    Roč. 44, č. 1 (2015), s. 116-130 ISSN 0264-9993 R&D Projects: GA ČR(CZ) GBP402/12/G097 Institutional support: RVO:67985556 Keywords : Bayesian model averaging * Central European countries * Inflation Dynamics Subject RIV: AH - Economics Impact factor: 0.997, year: 2015 http://library.utia.cas.cz/separaty/2015/E/baxa-0449816.pdf

  11. Convergence between the business cycles of Central and Eastern European countries and the Euro area

    OpenAIRE

    Nenad Stanisic

    2013-01-01

    Although entry to the Euro area (EA) is based only on fulfilment of the Maastricht criteria, implementation of optimum currency criteria and real economic convergence determines the benefits and costs of monetary integration. This paper focuses on the synchronization of business cycles among Central and Eastern European countries (CEECs) and the EA. Business cycles are extracted from GDP data series using a double Hodrick–Prescott filter method. The degree of co-movement of cycles is evaluate...

  12. Institutional barriers to organic farming in Central and Eastern European countries of the Baltic Sea region

    OpenAIRE

    Larsson, Markus; Morin, Louise; Hahn, Thomas; Sandahl, Johanna

    2013-01-01

    A window of opportunity to promote organic farming is open for the Central andEastern European Countries (CEEC) that joined the EU in 2004. The development oforganic farming has the potential to decrease the amount of nutrient leaching tothe Baltic Sea and could help to stop the environmental degradation of the Sea.However, this requires a diverse set of institutions. This paper explores theinstitutions that are lacking to promote the full development of organic farming inthe CEEC, using Swed...

  13. Ethical Leadership Styles of Future Managers in Central and Eastern European Countries

    OpenAIRE

    Anna Remišová; Anna Lašáková

    2013-01-01

    There is a limited understanding what the constituent elements of the ethical leadership are. Although various researchers defined ethical leadership as a specific leadership style, with typical personality traits and behaviors, the precise instantiation of the content of ethical leadership was only seldom investigated. The body of empirical research on ethical leadership is only slowly beginning to build up. Furthermore, the ethical leadership in Central and Eastern European countries (CEE c...

  14. CORRUPTION AND FOREIGN DIRECT INVESTMENT. EVIDENCE FROM CENTRAL AND EASTERN EUROPEAN STATES

    OpenAIRE

    Cristina Mihaela Amarandei

    2013-01-01

    This paper examines the impact of corruption on foreign direct investment inflows for ten Central and Eastern European states. The paper attempts to answer the question: what is the role of corruption in attracting foreign direct investments? Using the data from UNCTAD for foreign direct investment and Corruption Perception Index from Transparency International, for a period of 12 years, 2000-2012, we evaluate the specific impact of corruptions on FDI using GDP as control variable. Our result...

  15. Distinction between infections with European and American/vaccine type PRRS virus after vaccination with a modified-live PRRS virus vaccine

    DEFF Research Database (Denmark)

    Bøtner, Anette; Strandbygaard, Bertel; Sørensen, K. J.

    2000-01-01

    In July 1996 a modified live Porcine reproductive and respiratory syndrome (PRRS) vaccine, based on an American (US) strain of the PRRS virus (PRRSV), was licensed in Denmark. The vaccine was licensed for use in 3-18 week old pigs, exclusively. Starting during the middle of October 1996, several...... herds who had recently begun vaccination, experienced acute PRRS-like symptoms including an increasing number of abortions and stillborn piglets and an increasing mortality in the nursing period. During the period from October 1996 until May 1997, the PRRS virus (PRRSV), identified as the vaccine....../US type of PRRSV, was isolated from fetuses, dead piglets, pleural fluids and/or lung tissues from 114 of such herds. These findings indicated the spread of the vaccine virus to non-vaccinated sows followed by transplacental infection of fetuses. Also, a number of not previously PRRSV infected and non...

  16. The Far Right in Europe: A summary of attempts to define the concept, analyze its identity, and compare the Western European and Central European far right.

    Directory of Open Access Journals (Sweden)

    Lubomír Kopeček

    2007-12-01

    Full Text Available This paper focuses on the far right with emphasis on summing up some of its more widespread definitions, evaluating the reasons for classifying it as a distinctive family of parties, and comparing of the Western European and (post-Communist Central European far right. The text presents the theories of Piero Ignazi, Hans-Georg Betz, Cas Mudde, and other authors. The best working definition of the contemporary far right may be the four-element combination of nationalism, xenophobia, law and order, and welfare chauvinism proposed for the Western European environment by Cas Mudde. This concept allows for a basic ideological classification within a unified party family, despite the heterogeneity of the far right parties. Comparison of Central European far right parties with those of Western Europe shows that these four elements are present in Central Europe as well, though in a somewhat modified form, despite differing political, economic, and social influences.

  17. Tracing post-communist urban restructuring: Changing centralities in central and eastern European capitals

    Directory of Open Access Journals (Sweden)

    Jasna MARIOTTI

    2016-06-01

    Full Text Available Rapid political and economic changes after the collapse of communism led to dynamic processes of urban restructuring in cities, replacing old patterns and models of growth with ones in which capital and the market economy were central to growth and development. The transformation towards a market economy and the reintroduction of land ownership required the establishment of a new and decentralised decision-making system, with direct consequences for cities’ structure and form. As part of these urban transformations, there were clear changes in location patterns of retail structures in cities, illustrating diverse patterns of post-communist cities’ spatial organisation. This article explores and provides insight into some special features of this transformation, both before and after the collapse of communism, in Bucharest, Budapest, Prague and Sofia. Examining these cities offers an overview of post-communist spatial restructuring processes and explores their changing centralities, which ultimately led to fragmented cities and disintegrated urban fabric. This comparative study also outlines how different development patterns can arise in cities that shared a similar past.

  18. The evolving epidemiology of rotavirus gastroenteritis in central Portugal with modest vaccine coverage.

    Science.gov (United States)

    Rodrigues, Fernanda; Iturriza-Gómara, Miren; Marlow, Robin; Gray, Jim; Nawaz, Sameena; Januário, Luís; Finn, Adam

    2013-02-01

    Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010. To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter-spring seasons. Stool samples, collected throughout five epidemic seasons (January-June, 2006 to 2010) from children ≤ 36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped. A total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008-37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time. Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. Assessing vaccination coverage in the European Union: is it still a challenge?

    Science.gov (United States)

    Haverkate, Manon; D'Ancona, Fortunato; Johansen, Kari; van der Velden, Koos; Giesecke, Johan; Lopalco, Pier Luigi

    2011-08-01

    Assessing vaccination coverage is of paramount importance for improving quality and effectiveness of vaccination programs. In this article, some of the different systems that are used for assessing vaccination coverage within and outside the EU are reviewed in order to explore the need for improving vaccination coverage data quality. All countries in the EU have implemented vaccination programs for children, which include vaccinations to protect against between nine and 14 infectious diseases. Collecting and assessing vaccination coverage regularly is part of such programs, but the methods used vary widely. Some quality issues are evident when data reported through administrative methods are compared with seroprevalence studies or other surveys. More thorough assessment of vaccination coverage and more effective information sharing are needed in the EU. A homogeneous system for assessing vaccination coverage would facilitate comparability across countries and might increase the level of the quality of both the national and local systems. Cooperative and coordinated responses to vaccine-preventable disease threats might be improved by better information sharing.

  20. [The monitoring of influenza vaccination programs in Poland and European Union].

    Science.gov (United States)

    Brydak, Lidia B

    2003-01-01

    Every year approximately 100,000 millions of cases of influenza are registered all over the world. In the United States of America from 20,000 to 40,000 people die due to influenza and its complications every year. Vaccination is the best way of protection against this disease and its serious complications. The clinical efficacy and economic benefits of influenza vaccination is well proved and substantiated. Each year the Advisory Committee on Immunization Practices (ACIP), WHO, Atlanta, USA publishes recommendations for influenza vaccinations indicating which groups of people and patients should be vaccinated for clinical reasons and which of them--for epidemiological reasons. Depending on the country, vaccination policies for influenza vaccinations are different. In Poland vaccination against influenza is recommended for all groups mentioned in ACIP document. Nevertheless, there is no reimbursement system for influenza vaccinations in our country, even only for high-risk groups. Desite this, from year to year more and more people are getting immunized. National campaign carried out by the National Influenza Center, Warsaw resulted in over 200-fold increase of number of doses of influenza vaccines distributed in the epidemic season 2001/2002 when compared with the season 1992/93. This fact shows the importance and efficacy of educational activities together with scientific studies for positive changes in patients' and physicians' attitude to influenza vaccinations.

  1. Economic evaluation of human papilloma virus vaccination in the European Union: a critical review.

    Science.gov (United States)

    Koleva, Daniela; De Compadri, Paola; Padula, Anna; Garattini, Livio

    2011-04-01

    The human papilloma virus (HPV) vaccine is a new and expensive vaccine potentially effective in the prevention of a cancer. We reviewed the economic evaluations (EEs) on the vaccine in the EU to assess their potential contribution to public decision-making in a fairly homogeneous setting where HPV vaccination has been widely adopted. A literature search on PubMed selected EEs on HPV vaccines in the EU for the period 2007-2010 using the terms "HPV vaccines" and "Costs and cost analysis." Fifteen articles were eventually selected. All studies were based on modelling techniques, either "cohort" or "dynamic transmission": three were cost utility, three cost-effectiveness, and the remainder included both. The ten studies explicitly assessing one of the two vaccines were all sponsored by their manufacturer, while the five studies unrelated to the vaccine type were funded by public agencies. Apart from two studies, utility estimates were always obtained from three US sources. Direct costs were always vaccination, diagnosis and treatment of related pathologies. Incremental cost-effectiveness ratio (ICER) results were less favourable when life years gained were valued rather than quality-adjusted life years, genital warts were excluded, and booster doses and extension of vaccination to men were included in the base-case analysis. All but one of the sponsored EEs recommend in favour of the vaccination strategy, which is dominant in one English study. The ICER results were very sensitive to discount rates, followed by duration of protection and vaccine price. At such an early stage, when the vaccines' efficacy have been demonstrated by well-designed studies, it is not possible (and not even reasonable) to wait for several years to measure their effectiveness; public decision-makers might benefit more from EEs designed to indicate sustainable prices using realistic estimates of crucial variables like coverage rates, rather than referring to a large number of assumptions in

  2. Cultural Dimensions and Leadership Styles Perceived by Future Managers: Differences between Slovenia and a Cluster of Central European Countries

    National Research Council Canada - National Science Library

    Pučko, Danijel; Čater, Tomaž

    2011-01-01

    .... business and engineering students) in both Slovenia and a cluster of Central European (CE) countries regarding actual cultural practices in their social environments, the value systems they possess and their attitudes to leadership styles...

  3. Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

    NARCIS (Netherlands)

    Novakovic, R.N.; Cavelaars, A.J.E.M.; Bekkering, G.E.; Roman-Vinas, B.; Ngo, J.; Gurinovic, M.; Glibetic, M.; Golesorkhi, M.; Warthon-Medina, M.; Satalic, Z.; Geelen, A.; Serra Majem, L.; Veer, van 't P.; Groot, de C.P.G.M.

    2013-01-01

    Objective: To compare micronutrient intakes and status in Central and Eastern Europe (CEE) with those in other European countries and with reference values. Design: Review of the micronutrient intake/status data from open access and grey literature source

  4. Migration of Ukrainians to Central European countries in the context of the Postmaidan internal and international crisis

    National Research Council Canada - National Science Library

    Myroslava Lendel

    2016-01-01

    .... Among factors that have influenced the movement of citizens have been the migration policy of Ukraine, the EU and Central European countries, which has become more positive rather than a critical...

  5. The Integration of MEPs from Central and Eastern Europe into the European Parliament

    Directory of Open Access Journals (Sweden)

    Radko Hokovský

    2012-04-01

    Full Text Available This article evaluates the level of integration of Members of the European Parliament from Central and Eastern Europe in the European Parliament after the EU enlargements of 2004 and 2007. The main objective is to address the puzzle of how the European Parliament’s political groups could maintain or even increase their voting cohesion after the influx of a significantly large number of new MEPs coming from countries with different historical experience, socio-economic characteristics, and political and party systems. Three indicators of MEP integration are defined: integration into parliamentary leadership, integration into parliamentary work, and integration into voting patterns. The article uses data from the VoteWatch.eu website on MEPs’ activities and voting between the years 2004-2011, as well as data from official documents of the European Parliament and its political groups. Analysis of the data reveals that the new member states’ MEPs were significantly under-represented in parliamentary leadership and key legislative activities, despite the fact that their voting loyalty to their political groups was greater than that of their colleagues from older member states.

  6. Safety and efficacy of a novel European vaccine for porcine reproductive and respiratory virus in bred gilts.

    Science.gov (United States)

    Piontkowski, Michael D; Kroll, Jeremy; Orveillon, Francois-Xavier; Kraft, Christian; Coll, Teresa

    2016-10-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) can be devastating to commercial breeding operations. The objective of this study was to evaluate a novel European PRRSV vaccinal strain for safety and efficacy in bred gilts. In 2 experiments, 110 gilts were vaccinated intramuscularly and the vaccine was evaluated for safety and efficacy. Gilts in Experiment 1 were evaluated for local and systemic reactions and gilts in both experiments were observed for clinical signs of disease through farrow. In both experiments, piglet clinical observations, piglet average daily weight gain (ADWG), gilt serology [determined by enzyme-linked immunosorbent assay (ELISA)], gilt and piglet viremia [determined by quantitative real-time polymerase chain reaction (qPCR)], as well as piglet lung lesion scores and PRRS virus in lung tissue (qPCR) were determined. The vaccine was shown to be safe as there were no significant differences among groups in either experiment. Efficacy was established in Experiment 2 as both vaccinated groups were associated with desirable significant differences in percentage of gilts with abnormal clinical findings; gilt viral load post-challenge [day 125, day of farrowing (DOF), and DOF + 13]; percentages of alive, healthy live, weak live, and mummified piglets per litter at farrowing and weaning; percentage of piglets per gilt that were positive for viremia; percentage of piglets per gilt with clinical disease; and piglet viral load on DOF. It was concluded that a vaccine formulated from the PRRSV modified live virus (MLV) strain 94881 is a safe and effective method of protection against the detrimental effects of virulent PRRSV infection in breeding female pigs.

  7. The European central bank and the us federal reserve as lender of last resort

    Directory of Open Access Journals (Sweden)

    Herr Hansjörg

    2014-01-01

    Full Text Available Without a lender of last resort financial stability is not possible and systemic financial crises get out of control. During and after the Great Recession the US Federal Reserve System (Fed and the European Central Bank (ECB took on the role of lender of last resort in a comprehensive way. The Fed stabilised the financial system, including the shadow banking system. However, the chance to fundamentally restructure the financial system was not used. The ECB was confronted with sovereign debt crises and an incomplete integration of the European Monetary Union (EMU. It followed a kind of “muddling through” to keep the Euro area together. In the EMU not only a fundamental restructuring of the financial system is needed but also a deeper economic and political integration. The Fed and the ECB both were the most important institutions to avoid repetition of the 1930s.

  8. Determinants of non-performing loans in Central and Eastern European countries

    Directory of Open Access Journals (Sweden)

    Bruna Škarica

    2014-03-01

    Full Text Available This paper analyses the determinants of the changes in the non-performing loan (NPL ratio in selected European emerging markets. The model was estimated on a panel dataset using a fixed effects estimator for seven Central and Eastern European (CEE countries between Q3:2007 and Q3:2012. The countries analyzed are Bulgaria, Croatia, Czech Republic, Hungary, Latvia, Romania and Slovakia. Although the literature on NPLs is quite extensive, this is the first empirical research on the countries of CEE region using aggregate, country-level data on problem loans. The results suggest that the primary cause of high levels of NPLs is the economic slowdown, which is evident from statistically significant and economically large coefficients on GDP, unemployment and the inflation rate.

  9. The Domestic Politics of Public Debt: A Central and Eastern European Perspective

    Directory of Open Access Journals (Sweden)

    István BENCZES

    2014-02-01

    Full Text Available According to Alesina and Tabellini (1990, persistent deficit and its consequence, debt accumulation, cannot be explained by myopia or political business cycles exclusively. Instead, there is a tendency for incumbent politicians to use both deficit and debt strategically in order to severely limit the new incoming coalition’s spending capacities. Although the relevance of the model was tested in the context of advanced industrialised countries, no systematic analysis has been conducted yet on Central and Eastern European ones. The article argues accordingly that public debt did serve the strategic aims of incumbents in Hungary, Poland and, to a lesser extent, the Czech Republic, but the strategic manipulation of debt was much less straightforward in other cases. It was rather the accession to the European Union (especially its timing that served as a strategic variable in the reform of public finances in most of the countries in the region.

  10. Predicting Hybrid Performances for Quality Traits through Genomic-Assisted Approaches in Central European Wheat

    KAUST Repository

    Liu, Guozheng

    2016-07-06

    Bread-making quality traits are central targets for wheat breeding. The objectives of our study were to (1) examine the presence of major effect QTLs for quality traits in a Central European elite wheat population, (2) explore the optimal strategy for predicting the hybrid performance for wheat quality traits, and (3) investigate the effects of marker density and the composition and size of the training population on the accuracy of prediction of hybrid performance. In total 135 inbred lines of Central European bread wheat (Triticum aestivum L.) and 1,604 hybrids derived from them were evaluated for seven quality traits in up to six environments. The 135 parental lines were genotyped using a 90k single-nucleotide polymorphism array. Genome-wide association mapping initially suggested presence of several quantitative trait loci (QTLs), but cross-validation rather indicated the absence of major effect QTLs for all quality traits except of 1000-kernel weight. Genomic selection substantially outperformed marker-assisted selection in predicting hybrid performance. A resampling study revealed that increasing the effective population size in the estimation set of hybrids is relevant to boost the accuracy of prediction for an unrelated test population.

  11. Predicting Hybrid Performances for Quality Traits through Genomic-Assisted Approaches in Central European Wheat.

    Directory of Open Access Journals (Sweden)

    Guozheng Liu

    Full Text Available Bread-making quality traits are central targets for wheat breeding. The objectives of our study were to (1 examine the presence of major effect QTLs for quality traits in a Central European elite wheat population, (2 explore the optimal strategy for predicting the hybrid performance for wheat quality traits, and (3 investigate the effects of marker density and the composition and size of the training population on the accuracy of prediction of hybrid performance. In total 135 inbred lines of Central European bread wheat (Triticum aestivum L. and 1,604 hybrids derived from them were evaluated for seven quality traits in up to six environments. The 135 parental lines were genotyped using a 90k single-nucleotide polymorphism array. Genome-wide association mapping initially suggested presence of several quantitative trait loci (QTLs, but cross-validation rather indicated the absence of major effect QTLs for all quality traits except of 1000-kernel weight. Genomic selection substantially outperformed marker-assisted selection in predicting hybrid performance. A resampling study revealed that increasing the effective population size in the estimation set of hybrids is relevant to boost the accuracy of prediction for an unrelated test population.

  12. Native and European haplotypes of Phragmites Australis (common reed) in the central Platte River, Nebraska

    Science.gov (United States)

    Larson, D.L.; Galatowitsch, S.M.; Larson, J.L.

    2011-01-01

    Phragmites australis (common reed) is known to have occurred along the Platte River historically, but recent rapid increases in both distribution and density have begun to impact habitat for migrating sandhill cranes and nesting piping plovers and least terns. Invasiveness in Phragmites has been associated with the incursion of a European genotype (haplotype M) in other areas; determining the genotype of Phragmites along the central Platte River has implications for proper management of the river system. In 2008 we sampled Phragmites patches along the central Platte River from Lexington to Chapman, NE, stratified by bridge segments, to determine the current distribution of haplotype E (native) and haplotype M genotypes. In addition, we did a retrospective analysis of historical Phragmites collections from the central Platte watershed (1902-2006) at the Bessey Herbarium. Fresh tissue from the 2008 survey and dried tissue from the herbarium specimens were classified as haplotype M or E using the restriction fragment length polymorphism procedure. The European haplotype was predominant in the 2008 samples: only 14 Phragmites shoots were identified as native haplotype E; 224 were non-native haplotype M. The retrospective analysis revealed primarily native haplotype individuals. Only collections made in Lancaster County, near Lincoln, NE, were haplotype M, and the earliest of these was collected in 1973. ?? 2011 Copyright by the Center for Great Plains Studies, University of Nebraska-Lincoln.

  13. Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.

    Science.gov (United States)

    Yoneyama, S; Yao, J; Guo, X; Fernandez-Rhodes, L; Lim, U; Boston, J; Buzková, P; Carlson, C S; Cheng, I; Cochran, B; Cooper, R; Ehret, G; Fornage, M; Gong, J; Gross, M; Gu, C C; Haessler, J; Haiman, C A; Henderson, B; Hindorff, L A; Houston, D; Irvin, M R; Jackson, R; Kuller, L; Leppert, M; Lewis, C E; Li, R; Le Marchand, L; Matise, T C; Nguyen, K-Dh; Chakravarti, A; Pankow, J S; Pankratz, N; Pooler, L; Ritchie, M D; Bien, S A; Wassel, C L; Chen, Y-DI; Taylor, K D; Allison, M; Rotter, J I; Schreiner, P J; Schumacher, F; Wilkens, L; Boerwinkle, E; Kooperberg, C; Peters, U; Buyske, S; Graff, M; North, K E

    2017-02-01

    Central adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of body mass index (BMI) and are gaining clinically utility. Several studies report genetic variants associated with central adiposity, but most utilize only European ancestry populations. Understanding whether the genetic associations discovered among mainly European descendants are shared with African ancestry populations will help elucidate the biological underpinnings of abdominal fat deposition. To identify the underlying functional genetic determinants of body fat distribution, we conducted an array-wide association meta-analysis among persons of African ancestry across seven studies/consortia participating in the Population Architecture using Genomics and Epidemiology (PAGE) consortium. We used the Metabochip array, designed for fine-mapping cardiovascular-associated loci, to explore novel array-wide associations with WC and WHR among 15 945 African descendants using all and sex-stratified groups. We further interrogated 17 known WHR regions for African ancestry-specific variants. Of the 17 WHR loci, eight single-nucleotide polymorphisms (SNPs) located in four loci were replicated in the sex-combined or sex-stratified meta-analyses. Two of these eight independently associated with WHR after conditioning on the known variant in European descendants (rs12096179 in TBX15-WARS2 and rs2059092 in ADAMTS9). In the fine-mapping assessment, the putative functional region was reduced across all four loci but to varying degrees (average 40% drop in number of putative SNPs and 20% drop in genomic region). Similar to previous studies, the significant SNPs in the female-stratified analysis were stronger than the significant SNPs from the sex-combined analysis. No novel associations were detected in the array-wide analyses. Of 17 previously identified loci, four loci replicated in the African ancestry populations of this

  14. Mechanisms for Amplified Central European Summer Precipitation Extremes in a Warmer Mediterranean Climate

    Science.gov (United States)

    Volosciuk, Claudia; Maraun, Douglas; Semenov, Vladimir; Tilinina, Natalia; Latif, Mojib

    2015-04-01

    Central European climate is influenced by the Mediterranean Sea, where a strong increase in sea surface temperature (SST) has been observed during the last four decades. One example of extreme weather events are cyclones following the "Vb" pathway. These cyclones are generated over the Mediterranean Sea, travel northeastwards around the Alps and then hit central European countries. These cyclones carry large amounts of moisture and cause extreme precipitation, and subsequently flooding, particularly in summer. To investigate the mechanisms causing increased summer extreme precipitation due to increased Mediterranean SST in Europe, we analyze a series of simulations with the atmospheric general circulation model ECHAM5. In the control run, we forced the model with the 1970-1999 SST climatology. In an additional run, we replaced the Mediterranean and Black Sea SST forcing with the climatology of the warmer 2000-2012 period. ECHAM5 was run at high horizontal resolution (T159) and integrated for 40 years in each experiment. 20-season return levels were derived as a measure of extreme precipitation for daily precipitation in JJA (June - August). These return levels are estimated as quantiles of a stationary generalized Pareto distribution, based on exceedances of the 95th precipitation percentile. We have shown in a previous contribution that precipitation return levels in JJA increase along the Vb cyclone track although the number of Vb cyclones does not increase. Here we discuss the mechanisms responsible for this increase. Due to the warmer climate in the Mediterranean region, climatological mean evaporation and precipitable water in the atmosphere are increased. On extreme days, composites show an even further increase in precipitable water over the central European region. On these extreme days, a higher sea level pressure gradient between central Europe and the Atlantic causes enhanced cyclonic flow that transports more moisture from the Mediterranean region to

  15. The Short and Long Term Performance Persistence in the Central European Banking Industry

    Directory of Open Access Journals (Sweden)

    Krzysztof Jackowicz

    2011-12-01

    Full Text Available This article investigates the scale of performance persistence in the Central European banking industry. Contrary to the existing literature, we test not only for the short-term performance persistence but we propose also a novel method of analyzing the long-term persistence. Using an extensive dataset, covering the 1992-2009 period, we establish that banks’ results are strongly persistent in two-years sub-periods as well as in the long-run. Moreover, we find that the strength of studied phenomenon is not significantly influenced by the macroeconomic environment, banks size and capital base and country-specific factors.

  16. The short and long term performance persistence in the Central European banking industry

    OpenAIRE

    Krzysztof Jackowicz; Oskar Kowalewski; Łukasz Kozłowski

    2011-01-01

    This article investigates the scale of performance persistence in the Central European banking industry. Contrary to the existing literature, we test not only for the short-term performance persistence but we propose also a novel method of analyzing the long-term persistence. Using an extensive dataset, covering the 1992-2009 period, we establish that banks’ results are strongly persistent in two-years sub-periods as well as in the long-run. Moreover, we find that the strength of studied phen...

  17. Frames in contestation: gendering domestic violence policies in five central and eastern European countries.

    Science.gov (United States)

    Krizsan, Andrea; Popa, Raluca Maria

    2014-07-01

    The article looks at the translation of international norms on domestic violence to the national level in five Central and Eastern European countries. It argues that translation brings a concept of domestic violence, which stretches gender equality ideas underpinning international norms so as to be easier to endorse by mainstream policy actors, and results in policies framed in degendered individual rights terms. The potential for keeping gender equality in focus is then guaranteed by gendering policy processes through empowerment of gender equality actors at all stages. Absence of ownership of the policy by gender equality actors risks co-optation by frames contesting gender equality. © The Author(s) 2014.

  18. Lichens of neglected habitats in Eastern and East-Central European lowlands

    Directory of Open Access Journals (Sweden)

    Jurga Motiejūnaitē

    2013-12-01

    Full Text Available Situation of lichens of aquatic and transient habitats in Eastern and East-Central European lowlands is discussed basing on example of several selected species: Leptogium biatorinum, Sarcosagium campestre, Steinia geophana, Verrucaria aquatilis, V. hydrela, V. praetermissa, V. xyloxena. Both habitat types are generally very much neglected in the region and all species show large spatial gaps in recording, which makes it difficult to judge both about their true distribution limits and spreading dynamics. On the other hand, targeted search through the suitable habitats and abundance of such indicate that many of these lichens are probably not uncommon in the region.

  19. The European Union’s Military Operation in the Central African Republic

    DEFF Research Database (Denmark)

    Højstrup Christensen, Gitte; Norvanto, Elisa; Mandrup, Thomas

    Since the Central African Republic (CAR) gained its independence from France in 1960, the country has been troubled with internal conflicts. The country’s instability is characterised by post-colonial ethnic tensions, poverty, crime, military coups, government corruption and a weak security sector....... Following an escalation of conflicts in 2013 international actors such as the European Union began focussing their efforts on stabilising and rehabilitating the country. In 2014 the EU deployed a military operation with the overall goal of contributing to a safe and secure environment and providing...

  20. Bringing the environment in: early Central European contributions to an ecologically oriented psychology of perception.

    Science.gov (United States)

    Radler, Jan

    2015-11-01

    This article explores the Central European philosophical roots of perceptual psychology from a historical perspective. It will be shown that Alexius Meinong's notion of a forum of perception is the point of departure for a beginning inclusion of external factors in explaining perception. This conclusion is mainly because of Fritz Heider's early contributions on perception and its influence on Egon Brunswik. In addition, the impact of Meinong and Edmund Husserl-both students of Franz Brentano-on Brunswik's teacher, Karl Bühler, is highlighted. (c) 2015 APA, all rights reserved).

  1. Analysis of the Voting Method used in the European Central Bank

    Directory of Open Access Journals (Sweden)

    Honorata Sosnowska

    2013-01-01

    Full Text Available Game theoreticians usually deal with standard voting methods such as plurality voting or approval voting. In reality however, some complicated non-standard voting methods are used. In this paper the voting method and rotation scheme have been presented used by the Governing Council of the European Central Bank (ECB, as it enlarges to accommodate new members of the economic and monetary union. We present game theoretical approaches for analyzing this method and different methods of computing the Shapley value for games connected with voting under such rotation schemes. (original abstract

  2. CORRUPTION AND FOREIGN DIRECT INVESTMENT. EVIDENCE FROM CENTRAL AND EASTERN EUROPEAN STATES

    Directory of Open Access Journals (Sweden)

    Cristina Mihaela Amarandei

    2013-09-01

    Full Text Available This paper examines the impact of corruption on foreign direct investment inflows for ten Central and Eastern European states. The paper attempts to answer the question: what is the role of corruption in attracting foreign direct investments? Using the data from UNCTAD for foreign direct investment and Corruption Perception Index from Transparency International, for a period of 12 years, 2000-2012, we evaluate the specific impact of corruptions on FDI using GDP as control variable. Our results confirm the majority of literature and show a negative significant relation between the variables analyzed, but at a lower intensity than expected.

  3. The Effect of Oral Vaccination with Mycobacterium bovis BCG on the Development of Tuberculosis in Captive European Badgers (Meles meles)

    Science.gov (United States)

    Chambers, Mark A.; Aldwell, Frank; Williams, Gareth A.; Palmer, Si; Gowtage, Sonya; Ashford, Roland; Dalley, Deanna J.; Davé, Dipesh; Weyer, Ute; Salguero, Francisco J.; Nunez, Alejandro; Nadian, Allan K.; Crawshaw, Timothy; Corner, Leigh A. L.; Lesellier, Sandrine

    2017-01-01

    The European badger (Meles meles) is a reservoir host of Mycobacterium bovis and responsible for a proportion of the tuberculosis (TB) cases seen in cattle in the United Kingdom and Republic of Ireland. An injectable preparation of the bacillus Calmette-Guérin (BCG) vaccine is licensed for use in badgers in the UK and its use forms part of the bovine TB eradication plans of England and Wales. However, there are practical limitations to the widespread application of an injectable vaccine for badgers and a research priority is the development of an oral vaccine deliverable to badgers in bait. Previous studies reported the successful vaccination of badgers with oral preparations of 108 colony forming units (CFU) of both Pasteur and Danish strains of BCG contained within a lipid matrix composed of triglycerides of fatty acids. Protection against TB in these studies was expressed as a reduction in the number and apparent progression of visible lesions, and reductions in the bacterial load and dissemination of infection. To reduce the cost of an oral vaccine and reduce the potential for environmental contamination with BCG, it is necessary to define the minimal efficacious dose of oral BCG for badgers. The objectives of the two studies reported here were to compare the efficacy of BCG Danish strain in a lipid matrix with unformulated BCG given orally, and to evaluate the efficacy of BCG Danish in a lipid matrix at a 10-fold lower dose than previously evaluated in badgers. In the first study, both BCG unformulated and in a lipid matrix reduced the number and apparent progression of visible lesions and the dissemination of infection from the lung. In the second study, vaccination with BCG in the lipid matrix at a 10-fold lower dose produced a similar outcome, but with greater intra-group variability than seen with the higher dose in the first study. Further research is needed before we are able to recommend a final dose of BCG for oral vaccination of badgers against TB or

  4. The Migration Crisis from the East-Central European Perspective: Challenges for Regional Security

    Directory of Open Access Journals (Sweden)

    Renata Podgórzańska

    2017-12-01

    Full Text Available Nowadays, the common denominator of involvement of the EastCentral Europe in the international arena, and above all, the premise determining community of interest expressed in the European Union is the migration crisis. Despite the different circumstances of activity in the context of the migration crisis, states in the region express similar opinions on the consequences of immigration for security in the region. Above all, they emphasise the implications of immigration for the internal security of states. Given the complex nature of migration, this article focuses on the phenomenon of immigration in the EU, determining the causes of the escalation of the influx of immigrants and, above all, identifying the consequences for the security of states of East-Central Europe.

  5. The Eastring gas pipeline in the context of the Central and Eastern European gas supply challenge

    Science.gov (United States)

    Mišík, Matúš; Nosko, Andrej

    2017-11-01

    Ever since the 2009 natural gas crisis, energy security has been a crucial priority for countries of Central and Eastern Europe. Escalating in 2014, the conflict between Ukraine and Russia further fuelled negative expectations about the future development of energy relations for the region predominantly supplied by Russia. As a response to the planned cessation of gas transit through the Brotherhood pipeline, which brings Russian gas to Europe via Ukraine and Slovakia, the Slovak transmission system operator Eustream proposed the Eastring pipeline. This Perspective analyses this proposal and argues that neither the perceived decrease in Slovak energy security nor the loss of economic rent from the international gas transit should be the main policy driver behind such a major infrastructure project. Although marketed as an answer to current Central and Eastern European gas supply security challenges, the Eastring pipeline is actually mainly focused on issues connected to the Slovak gas transit.

  6. Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes.

    Science.gov (United States)

    Singh, Dhiraj Kumar; Dwivedi, Ved Prakash; Ranganathan, Anand; Bishai, William R; Van Kaer, Luc; Das, Gobardhan

    2016-11-01

    Tuberculosis is the oldest known infectious disease, yet there is no effective vaccine against adult pulmonary tuberculosis. Emerging evidence indicates that T-helper 1 and T-helper 17 cells play important roles in host protection against tuberculosis. However, tuberculosis vaccine efficacy in mice is critically dependent on the balance between antigen-specific central memory T (Tcm) and effector memory T (Tem) cells. Specifically, a high Tcm/Tem cell ratio is essential for optimal vaccine efficacy. Here, we show that inhibition of Kv1.3, a potassium channel preferentially expressed by Tem cells, by Clofazimine selectively expands Tcm cells during BCG vaccination. Furthermore, mice that received clofazimine after BCG vaccination exhibited significantly enhanced resistance against tuberculosis. This superior activity against tuberculosis could be adoptively transferred to naive, syngeneic mice by CD4+ T cells. Therefore, clofazimine enhances Tcm cell expansion, which in turn provides improved vaccine efficacy. Thus, Kv1.3 blockade is a promising approach for enhancing the efficacy of the BCG vaccine in humans. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  7. The Image of the East-Central European in Rose Tremain’s The Road Home

    Directory of Open Access Journals (Sweden)

    Harasztos Ágnes

    2015-12-01

    Full Text Available In Rose Tremain’s The Road Home, the culture clash of the British and the East-Central European is portrayed through a complex symbolism centred on images of food, consumption and waste. This literary representation may shed light on British literary auto-images, as well as hetero-images of the Eastern European immigrant. The novel’s presentation of this culture shock is defined by the cultural historical and economic circumstances of the parties. Food and material provide the symbolic sphere where the relationship between Britain and East-Central Europe is characterized in terms of capitalist worldview as opposed to a post-communist existence. William Shakespeare’s Hamlet is the most important intertext for Tremain’s novel. Hamlet is obsessed with the vulnerability of material in light of the spiritual value attached to it in the form of human soul. Stephen Greenblatt’s ideas on food, waste and the Christian belief in divine existence residing in material objects - ideas that originate in early modern times - shed light on the motif of material and food in The Road Home. Seen through the symbolism of food and the idea of differing values being attached to matter, the narrative identity of Lev, the protagonist of Tremain’s work, experiences drastic change due to his encounter with the capitalist, British ‘other’.

  8. Real Style: Riegl and Early 20th Century Central European Art

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    Kimberly A. Smith

    2011-12-01

    Full Text Available Originally published in Centropa: Journal of Central European Art and Architecture 5, n. 1 (January 2005: 16-25. Kimberly A. Smith discusses the ways in which the understanding of style was articulated by intellectuals working in the late nineteenth century, primarily in Germany and Austria, and the epistemological repercussions of this shift in thinking for both the theory and practice of central European art in the years before World War I. Smith focuses in particular on the writings of Alois Riegl, in which this approach to thinking about style came to its most influential fruition, and proposes that Riegl’s conception of form had implications for artistic practice. Riegl’s methodological understanding of artistic form drew connections between morphological types and perceptions of reality, thereby altering the ways in which artists could conceive of aesthetic authenticity. Style itself could be seen as the harbinger of truth, opening up the possibility that any style might offer a genuine revelation of the real. Yet as Smith shows, the Rieglian theory of meaningful form may have encouraged an artistic pluralism that subverted the very Kunstwollen theory of historically unified style from which it sprung.

  9. Central European triathletes dominate Double Iron ultratriathlon – analysis of participation and performance 1985–2011

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    Sigg K

    2012-10-01

    Full Text Available Katrin Sigg,1 Beat Knechtle,1,2 Christoph Alexander Rüst,1 Patrizia Knechtle,2 Romuald Lepers,3 Thomas Rosemann11Institute of General Practice and Health Services Research, University of Zurich, Zurich; 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: A recent study showed that European triathletes performed faster in Double Iron ultratriathlons than North American athletes. The present study analyzed triathletes participating in Double Iron ultratriathlons to determine the origin of the fastest Double Iron ultratriathletes, focusing on European countries.Methods: Participation and performance trends of finishers in Double Iron ultratriathlons from 1985–2011 of the different countries were investigated. Additionally, the performance trends of the top three women and men overall from 2001–2011 were analyzed.Results: A total of 1490 finishers originated from 24 different European countries and the United States. The number of European triathletes increased for both women (r2 = 0.56; P < 0.01 and men (r2 = 0.63; P < 0.01. The number of the North American triathletes increased for women (r2 = 0.25; P < 0.01, but not for men (r2 = 0.02; P > 0.05. Hungarian triathletes showed a significant improvement in both overall race times and in cycling split times, Swiss triathletes improved both their swim and run times, and French triathletes improved their swim times.Conclusion: Men and women triathletes from Central European countries such as France, Germany, Switzerland, and Hungary improved Double Iron ultratriathlon overall race times and split times during the 26-year period. The reasons might be the social and economic factors required to be able to participate in such an expensive and lavish race. Also, a favorable climate may provide the ideal conditions for successful training. Future studies need to investigate the motivational aspects of European

  10. AGRICULTURAL SECTOR, RURAL ENVIRONMENT AND BIODIVERSITY IN THE CENTRAL AND EASTERN EUROPEAN EU MEMBER STATES

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    JAAN LIIRA

    2008-06-01

    Full Text Available During the second half of the 20th century, agriculture and the rural environment diverged in Western and Central and Eastern European countries (CEEC. CEE countries itself are heterogeneous in the respect of land use intensity and history. In the current review we focus on the comparison of the agricultural sector and threats on biodiversities of EU new-member countries from Central and Eastern Europe and the old EU(15 member states. The clustering of countries revealed groups distinguished according to the level of their economic productivity, discriminating mostly among eastern and western European countries. CEE countries sub-divided according to geographic region, including also some old members of the EU. Within the western cluster, two large sub-clusters became evident according to economy affected by altitudinal and climatic differences. Partly because there are still areas where the intensity of land use remained low, the biological diversity in many regions of Central and Eastern Europe has remained high. However, loss of extensively used habitats, the restoration on intensive agriculture, reforestation with exotic species and urbanization are major threats to nature in CEE countries. The estimated variability among CEE countries is caused by different historical and cultural backgrounds of those countries. Due to the complexity and geographical diversity of driving forces, there remains much uncertainty in the possible impacts of particular factors on land use. This complexity and diversity have to be considered when planningeconomic as well as ecological means for developing the agricultural sector and conserving biodiversity in the future of CEE countries.

  11. Bunker Cave stalagmites: an archive for central European Holocene climate variability

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    J. Fohlmeister

    2012-10-01

    Full Text Available Holocene climate was characterised by variability on multi-centennial to multi-decadal time scales. In central Europe, these fluctuations were most pronounced during winter. Here we present a record of past winter climate variability for the last 10.8 ka based on four speleothems from Bunker Cave, western Germany. Due to its central European location, the cave site is particularly well suited to record changes in precipitation and temperature in response to changes in the North Atlantic realm. We present high-resolution records of δ18O, δ13C values and Mg/Ca ratios. Changes in the Mg/Ca ratio are attributed to past meteoric precipitation variability. The stable C isotope composition of the speleothems most likely reflects changes in vegetation and precipitation, and variations in the δ18O signal are interpreted as variations in meteoric precipitation and temperature. We found cold and dry periods between 8 and 7 ka, 6.5 and 5.5 ka, 4 and 3 ka as well as between 0.7 and 0.2 ka. The proxy signals in the Bunker Cave stalagmites compare well with other isotope records and, thus, seem representative for central European Holocene climate variability. The prominent 8.2 ka event and the Little Ice Age cold events are both recorded in the Bunker Cave record. However, these events show a contrasting relationship between climate and δ18O, which is explained by different causes underlying the two climate anomalies. Whereas the Little Ice Age is attributed to a pronounced negative phase of the North Atlantic Oscillation, the 8.2 ka event was triggered by cooler conditions in the North Atlantic due to a slowdown of the thermohaline circulation.

  12. TILIA-DOMINATED CALCICOLOUS FORESTS IN THE CZECH REPUBLIC FROM A CENTRAL EUROPEAN PERSPECTIVE

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    M. CHYTRY

    1997-04-01

    Full Text Available The Seslerio albicantis-Tilietum cordatae is described as a new association of the calcicolous forests in the Czech Republic. It includes species-rich Tilia cordata or T. platyphyllos dominated forests with a mixture of mesophilous forest species and thermophilous oak-forest species in the field layer, confined to shallow soils of the upper slopes. During the postglacial period, these forests probably developed from Sesleria albicans-grassland and Corylus avellana-scrub and preserved a number of relict species. Comparative analysis of selected literature data on Central European calcicolous forests dominated by Tilia species yielded 6 major floristically defined groups and a few communities of local importance. These groups include: (1 Asperulo taurinae-Tilietum of Swiss föhn valleys, (2 Aceri-Tilietum of central and southern Germany and NW Switzerland, (3 Aceri-Carpinetum aconitetosum vulpariae of the Czech Republic (nutrient-rich habitats, (4 Seslerio albicantis-Tilietum cordatae of the Czech Republic (nutrient-poor habitats, (5 Mercuriali-Tilietum of the Hungarian Central Range, (6 Tilio- Fraxinetum excelsioris of the Carpathian fringes in Hungary and Romania.

  13. TILIA-DOMINATED CALCICOLOUS FORESTS IN THE CZECH REPUBLIC FROM A CENTRAL EUROPEAN PERSPECTIVE

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    J. SADLO

    1997-01-01

    Full Text Available The Seslerio albicantis-Tilietum cordatae is described as a new association of the calcicolous forests in the Czech Republic. It includes species-rich Tilia cordata or T. platyphyllos dominated forests with a mixture of mesophilous forest species and thermophilous oak-forest species in the field layer, confined to shallow soils of the upper slopes. During the postglacial period, these forests probably developed from Sesleria albicans-grassland and Corylus avellana-scrub and preserved a number of relict species. Comparative analysis of selected literature data on Central European calcicolous forests dominated by Tilia species yielded 6 major floristically defined groups and a few communities of local importance. These groups include: (1 Asperulo taurinae-Tilietum of Swiss föhn valleys, (2 Aceri-Tilietum of central and southern Germany and NW Switzerland, (3 Aceri-Carpinetum aconitetosum vulpariae of the Czech Republic (nutrient-rich habitats, (4 Seslerio albicantis-Tilietum cordatae of the Czech Republic (nutrient-poor habitats, (5 Mercuriali-Tilietum of the Hungarian Central Range, (6 Tilio- Fraxinetum excelsioris of the Carpathian fringes in Hungary and Romania.

  14. Vaccinations

    Science.gov (United States)

    ... disease — reinforcing the importance of vaccines in your pet's preventive health care program. Are there risks? Any treatment carries some risk, but these risks should be weighed against the benefits of protecting your pet from potentially fatal diseases. ...

  15. PUBLIC POLICY, QUALITY OF INTITUTION AND ECONOMIC GROWTH IN CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    DOGARU DORIN-MADALIN

    2015-04-01

    Full Text Available This paper analyzes the relationship between economic performance and institutional development in several Central and Eastern European Countries. Our meta-argument is that the structural transformations at the levels of the quantitative variables and mechanisms are only a part of the transition processes. In order to view the big picture, the qualitative aspects related to public policies and institutions should also be considered. We test the linkages between the quality of public policies and institutions for seven Central and Eastern European countries (Bulgaria, Poland, Czech Republic, Hungary, Slovenia, Slovakia and Romania for a time span between 2001 and 2011. These countries are displaying a certain degree of heterogeneity in terms of economic performances and the design and implementation of public policies. We use for our analysis the World Bank indicators from World Wide Governance Indicators. In order to deal with the potential reverse causality issues, we employ Generalized Method of Moments Framework (GMM by using the lagged variables as instruments. The impact of governance indicators is statistically significant even if we use several control variables: exchange rate, unemployment, current account deficit, taxes burden and price stability. The corresponding Sargan and Arellano-Bond test for zero autocorrelation in first-differenced errors tests shows that the results display a corresponding robustness. The main policy implications for our findings may be synthesized by the thesis, according to which a proper design of public policies, a high degree of their effectiveness and accountability, a stable social and political environment together with the rule of law and efficient anticorruption mechanisms are critical determinants of economic growth even in emerging markets. The impact of the government “size , economic structure and markets” mechanisms , monetary policy and price stability , ownership structure and legal rights

  16. Systematic review on the evaluation criteria of orphan medicines in Central and Eastern European countries.

    Science.gov (United States)

    Zelei, Tamás; Molnár, Mária J; Szegedi, Márta; Kaló, Zoltán

    2016-06-04

    In case of orphan drugs applicability of the standard health technology assessment (HTA) process is limited due to scarcity of good clinical and health economic evidence. Financing these premium priced drugs is more controversial in the Central and Eastern European (CEE) region where the public funding resources are more restricted, and health economic justification should be an even more important aspect of policy decisions than in higher income European countries. To explore and summarize the recent scientific evidence on value drivers related to the health technology assessment of ODs with a special focus on the perspective of third party payers in CEE countries. The review aims to list all potentially relevant value drivers in the reimbursement process of orphan drugs. A systematic literature review was performed; PubMed and Scopus databases were systematically searched for relevant publications until April 2015. Extracted data were summarized along key HTA elements. From the 2664 identified publications, 87 contained relevant information on the evaluation criteria of orphan drugs, but only 5 had direct information from the CEE region. The presentation of good clinical evidence seems to play a key role especially since this should be the basis of cost-effectiveness analyses, which have more importance in resource-constrained economies. Due to external price referencing of pharmaceuticals, the relative budget impact of orphan drugs is expected to be higher in CEE than in Western European (WE) countries unless accessibility of patients remains more limited in poorer European regions. Equity principles based on disease prevalence and non-availability of alternative treatment options may increase the price premium, however, societies must have some control on prices and a rationale based on multiple criteria in reimbursement decisions. The evaluation of orphan medicines should include multiple criteria to appropriately measure the clinical added value of orphan

  17. A systematic review of economic evaluations of seasonal influenza vaccination for the elderly population in the European Union.

    Science.gov (United States)

    Shields, Gemma E; Elvidge, Jamie; Davies, Linda M

    2017-06-10

    The Council of the European Union (EU) has recommended that action should be taken to increase influenza vaccination in the elderly population. The aims were to systematically review and critically appraise economic evaluations for influenza vaccination in the elderly population in the EU. Electronic searches of the NHS Economic Evaluation, Health Technology Assessment, MEDLINE and Embase databases were run to identify full economic evaluations. Two levels of screening were used, with explicit inclusion criteria applied by two independent reviewers at each stage. Prespecified data extraction and critical appraisal were performed on identified studies. Results were summarised qualitatively. Of the 326 search results, screening identified eight relevant studies. Results varied widely, with the incremental cost-effectiveness ratio ranging from being both more effective and cheaper than no intervention to costing €4 59 350 per life-year gained. Cost-effectiveness was most sensitive to variations in influenza strain, vaccination type and strategy, population and modelling characteristics. Most studies suggest that vaccination is cost-effective (seven of eight studies identified at least one cost-effective scenario). All but one study used economic models to synthesise data from different sources. The results are uncertain due to the methods used and the relevance and robustness of the data used. Sensitivity analysis to explore these aspects was limited. Integrated, controlled prospective clinical and economic evaluations and surveillance data are needed to improve the evidence base. This would allow more advanced modelling techniques to characterise the epidemiology of influenza more accurately and improve the robustness of cost-effectiveness estimates. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  18. First European interlaboratory comparison of tetracycline and age determination with red fox teeth following oral rabies vaccination programs.

    Science.gov (United States)

    Robardet, Emmanuelle; Demerson, Jean-Michel; Andrieu, Sabrina; Cliquet, Florence

    2012-10-01

    The first European interlaboratory comparison of tetracycline and age determination with red fox (Vulpes vulpes) tooth samples was organized by the European Union Reference Laboratory for rabies. Performance and procedures implemented by member states were compared. These techniques are widely used to monitor bait uptake in European oral rabies vaccination campaigns. A panel of five red fox half-mandibles comprising one weak positive juvenile sample, two positive adult samples, one negative juvenile sample, and one negative adult sample were sent, along with a technical questionnaire, to 12 laboratories participating on a voluntary basis. The results of only three laboratories (25%) were 100% correct. False-negative results were more frequently seen in weak positive juvenile samples (58%) but were infrequent in positive adult samples (4%), probably due to differences in the ease of reading the two groups of teeth. Four laboratories (44%) had correct results for age determination on all samples. Ages were incorrectly identified in both adult and juvenile samples, with 11 and 17% of discordant results, respectively. Analysis of the technical questionnaires in parallel with test results suggested that all laboratories cutting mandible sections between the canine and first premolar obtained false results. All the laboratories using longitudinal rather than transverse sections and those not using a mounting medium also produced false results. Section thickness appeared to affect the results; no mistakes were found in laboratories using sections <150 μm thick. Factors having a potential impact on the success of laboratories were discussed, and recommendations proposed. Such interlaboratory trials underline the importance of using standardized procedures for biomarker detection in oral rabies vaccination campaigns. Several changes can be made to improve analysis quality and increase the comparability of bait uptake frequencies among member states.

  19. Determinants of FDI into Central and Eastern European Countries: Pull or Push Effect?

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    Burcak Polat

    2015-11-01

    Full Text Available Despite the growing interest in foreign direct investments (FDI, substantial uncertainty still exists regarding what stimulates foreign investors to operate in a foreign market and uneven distribution of FDI across countries. Using panel data for 2001 -2012 period, the major determinants of the FDI inflows into the Central and Eastern European Countries are analysed in this study. Strong evidence are found that while EU CR indices, EU and USA real GDP growth rates and global financial crisis have power to explain FDI inflows among all other push factors, labour cost, electricity price, real exchange rate and host CR indices have strong influential on FDI as the most effective pull factors. However, study fails to find any effect of openness, tax rates on commercial profits, USA CR indices, interest rate differentials and host real GDP growth on FDI.

  20. IMPORTANCE OF AGRI-FOOD SECTOR IN THE ECONOMIES OF CENTRAL-EAST EUROPEAN COUNTRIES

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    Ewelina Szuba

    2014-06-01

    Full Text Available This article attempts to present the importance of agri-food sector in the economies of Central-East European countries in consideration of their macroeconomic situation. The analysis was carried out on the data base from EU statistics, published by Eurostat (including the balance of inputs and outputs. The study shows that the position of agri-food sector in the national economy is dependent on the level of development of the state. In countries with better macroeconomic situation of the importance of agri-food sector in the entire economy is smaller, and the results are affected by the food industry. In countries with poor macroeconomic situation agri-food sector has a large share of the economy, despite the underperformance of production. Agriculture has the strongest impact on the situation.

  1. Educational Systems and Inequalities in Educational Attainment in Central and Eastern European Countries

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    Irena Kogan

    2012-06-01

    Full Text Available Before exploring the selectivity of educational attainment in detail, this article extensively describes the contours of educational systems in Central and Eastern European (CEE countries. These countries provide an interesting setting in view of their post-secondary education expansion and differentiation, as well as their variation in the degree of vocational orientation at the secondary level. Drawing on high quality, national micro data, we find that students from disadvantaged family backgrounds who manage to enter post-secondary education are ʽdivertedʼ to second-tier post-secondary institutions, while long-term university programs are more likely to be dominated by students whose parents have an academic background. At the secondary level, we confirm the patterns of negative selection among students from lower social backgrounds into lower vocational programs. This diversion effect at the secondary level is especially pronounced in CEE countries that inherited a strong secondary vocational system and reinstalled early tracking.

  2. Social normative perceptions of alcohol use and episodic heavy drinking among Central and Eastern European adolescents.

    Science.gov (United States)

    Page, Randy M; Ihasz, Ferenc; Hantiu, Iacob; Simonek, Jaromir; Klarova, Renata

    2008-01-01

    This study examined alcohol use and related social normative perceptions among a sample of 1,886 Central-Eastern European high school students. The youth represented in the study averaged 16.5 years of age and were from several localities in the countries of Hungary, Slovakia, Czech Republic, and Romania. Data for the study were collected through a school-based alcohol use survey that was completed in June 2005. Our results support the hypothesis that drinking was related to perception of the prevalence of alcohol use by schoolmates and by the number of friends who drink and/or engage in episodic heavy drinking. Specific implications of findings in terms of substance use prevention are discussed. In addition, the need for future research and the limitations of the current research are discussed. This study was largely financially supported through an international grant from the College of Health and Human Performance, Brigham Young University.

  3. Assessing the Sustainability of Credit Growth: The case of Central and Eastern European Countries

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    Coudert, Virginie

    2010-06-01

    Full Text Available Credit growth rates as high as 30% or 50% a year were observed in some Central Eastern European countries (CEECs in 2006-2007, such as the Baltic States, Bulgaria or Romania. This strong credit growth could have been due to the catching-up process but could also have been excessive, paving the way to the credit crunch that followed the crisis in 2008-2009. We try to assess the excessiveness of credit by applying a number of methods. First, we consider the gap between current credit and its long-term trend and we find some signs of credit booms, in several CEECs in 2005-2007. Second, we assess the "normal" growth of credit with regard to fundamentals through econometric estimations. Credit growth is also shown to have been excessive in several countries just before the 2008-2009 financial crisis.

  4. E-business and its Application in Conditions of Central European Market

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    Naci Tolga Saruc

    2013-07-01

    Full Text Available Aim of this paper is highlighting possibilities in effective utilization of Information and Communication Technologies for supporting entrepreneurship (e-business for Small and Medium enterprises. The core research carried on for duration of twelve months covered analysis and following presentation of possibilities of practical utilization of e-business applications. Furthermore research was oriented towards innovative forms of marketing communication in Real Corporation conducting business in Central European market. Analyzing data on collected findings can add value towards gaining a significant competitive advantage in form of better understanding of real facts influencing entrepreneurship in principle. This can lead consequently to positive influence on corporate effectiveness in the environment of Small and Medium enterprises.

  5. The spatial equity principle in the administrative division of the Central European countries.

    Science.gov (United States)

    Halás, Marián; Klapka, Pavel; Bačík, Vladimír; Klobučník, Michal

    2017-01-01

    The paper generally builds on the concept of justice in social science. It attempts to interpret this concept in a geographical and particularly in a spatial context. The paper uses the concept of accessibility to define the principle of spatial equity. The main objective of the paper is to propose an approach with which to assess the level of spatial equity in the administrative division of a territory. In order to fulfil this objective the paper theoretically discusses the concept of spatial equity and relates it to other relevant concepts, such as spatial efficiency. The paper proposes some measures of spatial equity and uses the territory of four Central European countries (Austria, the Czech Republic, Hungary, Slovakia) as example of the application of the proposed measures and the corroboration of the proposed approach. The analysis is based on the administrative division of four countries and is carried out at different hierarchical levels as defined by the Nomenclature of Units for Territorial Statistics (NUTS).

  6. The Eighth Central European Conference “Chemistry towards Biology”: Snapshot

    Directory of Open Access Journals (Sweden)

    András Perczel

    2016-10-01

    Full Text Available The Eighth Central European Conference “Chemistry towards Biology” was held in Brno, Czech Republic, on August 28–September 1, 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topics of the conference covered “Chemistry towards Biology”, meaning that the event welcomed chemists working on biology-related problems, biologists using chemical methods, and students and other researchers of the respective areas that fall within the common scope of chemistry and biology. The authors of this manuscript are plenary speakers and other participants of the symposium and members of their research teams. The following summary highlights the major points/topics of the meeting.

  7. Central and Eastern European Countries Focus on the Silk Road Economic Belt

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    GEORGE CORNEL DUMITRESCU

    2015-05-01

    Full Text Available The Silk Road Economic Belt, a strategic priority of the Chinese foreign policy in 2015, draws the attention to the countries of Central and Eastern Europe through the multiple benefits that it displays (investments, economic growth, trade between the countries along its corridors, job creation, infrastructure development, the strategic importance of being part of a grandiose multi-continental project. Among these benefits an important one is represented by the opportunities of Chinese investments in infrastructure, since the EU is suffering from a credit restraint. Also, The Silk Road Economic Belt could lead to a potential increase in the bilateral trade. Analyzing the literature in the field and the various official information available online, this paper aims to depict the Chinese project form the Eastern European perspective, identifying local priorities, conflicting interests, possible infrastructure projects, routes, focusing on two strategic countries in the region: Romania and Serbia, both displaying advantages and disadvantages.

  8. The Eighth Central European Conference “Chemistry towards Biology”: Snapshot†

    Science.gov (United States)

    Perczel, András; Atanasov, Atanas G.; Sklenář, Vladimír; Nováček, Jiří; Papoušková, Veronika; Kadeřávek, Pavel; Žídek, Lukáš; Kozłowski, Henryk; Watły, Joanna; Hecel, Aleksandra; Kołkowska, Paulina; Koča, Jaroslav; Svobodová-Vařeková, Radka; Pravda, Lukáš; Sehnal, David; Horský, Vladimír; Geidl, Stanislav; Enriz, Ricardo D.; Matějka, Pavel; Jeništová, Adéla; Dendisová, Marcela; Kokaislová, Alžběta; Weissig, Volkmar; Olsen, Mark; Coffey, Aidan; Ajuebor, Jude; Keary, Ruth; Sanz-Gaitero, Marta; van Raaij, Mark J.; McAuliffe, Olivia; Waltenberger, Birgit; Mocan, Andrei; Šmejkal, Karel; Heiss, Elke H.; Diederich, Marc; Musioł, Robert; Košmrlj, Janez; Polanński, Jarosław; Jampílek, Josef

    2017-01-01

    The Eighth Central European Conference “Chemistry towards Biology” was held in Brno, Czech Republic, on 28 August–1 September 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topics of the conference covered “Chemistry towards Biology”, meaning that the event welcomed chemists working on biology-related problems, biologists using chemical methods, and students and other researchers of the respective areas that fall within the common scope of chemistry and biology. The authors of this manuscript are plenary speakers and other participants of the symposium and members of their research teams. The following summary highlights the major points/topics of the meeting. PMID:27763518

  9. Land Mobility in a Central and Eastern European Land Consolidation Context

    DEFF Research Database (Denmark)

    Hartvigsen, Morten B.

    2014-01-01

    and small farm sizes through donor funded projects with international technical assistance. The approach has normally been voluntary and low land mobility in the project areas has often been a constraint. It is the aim of this paper to explore the problems and possible solutions related to low land mobility...... in a Central and Eastern European land consolidation context. The term land mobility is defined and the limited theory available is reviewed. Case studies of land mobility in land consolidation pilot projects in Moldova, Albania and Bosnia-Herzegovina show the correlation between land mobility and the success...... or failure of voluntary land consolidation projects. In situations with low land mobility, land consolidation instruments need in order to be successful to be supported by other land policy tools such as land banks. The use of existing state agricultural land is an obvious foundation for establishing a state...

  10. Sources of growth: Evidence from ten central and Eastern European countries during 1993-2008

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    Pop Silaghi Monica

    2015-01-01

    Full Text Available This paper carries out a growth accounting exercise for the 10 Central and Eastern European (CEE countries that are part of the European Union over the period 1993-2008. We estimate the capital share (α from a Cobb-Douglas production function in an intensive form, by employing panel data techniques. The Hausman and Chi-Square tests indicate that a Cross- Section Random Effects with Period Fixed Effects model best suits our data. Based on this model, we find a capital share between 0.45 and 0.83, higher than the usual 0.3-0.4 used in growth accounting literature. When we take into consideration the quality of labour force the estimated capital share slightly decreases, but still remains high, in a range between 0.39 and 0.79. Our growth accounting results reveal that, on average, capital per worker accumulation is the main engine of growth in CEE, followed by the contribution of total factor productivity (TFP. However, when dividing by sub-periods, we found that the contribution of TFP cannot be neglected since during 1997-2004 it proved to be the main engine of growth in some CEE countries (Czech Republic, Slovakia, Hungary, Lithuania and Romania. Some policy implications are offered based on our results.

  11. High-Speed Rail for Central and Eastern European Countries: A Conference Report

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    Jandová Monika

    2016-09-01

    Full Text Available The European transport strategy promotes the role of railways and expects that the key role in passenger transport should be played by high-speed rail (HSR. Although the core network of high-speed lines has already been built and is operating in Western Europe, there has been little coverage so far in Central and Eastern Europe (CEE. The aim of the conference “High-Speed Rail for CEE Countries” that took place in Prague in June 2016 was to put together academics, policy-makers, and practitioners interested in HSR and to formulate recommendations for CEE countries based on West European countries’ experience. Based on the conference presentations and subsequent discussion, the following conclusions were formulated. Firstly, there are many crucial differences in national HSR build-up and operation, which means that former experience of Western Europe is not directly applicable to CEE countries. Secondly, in comparing presentations discussing experiences in France, Britain, Italy, and Germany, it was concluded that the German approach-upgrading existing lines where possible and only building new lines for bottleneck sections-was the most likely appropriate solution in CEE. Lastly, CEE has the additional problem of many border crossings, with a reduction of traffic in comparison with purely domestic routes, and this effect has to be taken into account.

  12. Analysis of Fertility in Ten Central And Eastern European Countries After 1989

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    Dănuţ-Vasile JEMNA

    2014-06-01

    Full Text Available The establishment of democracy in the communist countries, which generated profound social and economic transformation, was accompanied by a decline in fertility. We attempt to provide an overall survey on fertility since 1989 in ten Central and Eastern European Countries, members of the European Union, and to identify the variables which explain the fertility decline. We will use univariate and multivariate statistical analysis to identify disparities between the ten countries, and the variables which explain these differences. Also, we developed a panel econometric model to confirm the hypothesis of a similar pattern of evolution for fertility in these countries and that the decline in fertility can be explained both through demographic and economic variables. The decline in fertility can be explained by economic growth, marriage, divorce, abortion, and migration. The empirical evidence presented in this paper supports the view that the decline in fertility over the 1989s represents the continuation of a longstanding trend of the previous period, according to the demographic transition theory, but its speed and magnitude has been influenced by the new social and economic landscape. These results can be useful for public authorities of the CEE countries to rethinking demographic policies and to ensure the sustainability of demographic growth.

  13. [Stature estimation from sagittal and coronal suture lengths for Central European individuals].

    Science.gov (United States)

    Kolencherry, Tesseera V; Birngruber, Christoph G; Ramsthaler, Frank; Verhoff, Marcel A; Kölzer, Sarah C

    2016-01-01

    $Human skulls frequently represent the only skeletal remains of an unidentified corpse available for forensic osteological examination. Skulls are very useful in reliably determining sex and also yield fairly good clues to an individual's age and ancestry. To date, however, a sufficiently accurate correlation between skull measurements and stature could not be found. In contrast, the results of a study by Rao et al. (2009) seemed to be promising, by finding a good correlation between the length of the coronal and sagittal sutures and stature in a male Indian population. In an attempt to verify the transferability of their results to a Central European population, the authors measured the length of the sagittal and coronal sutures with a tape measure along with body height in the course of 117 autopsies performed at the Institute of Forensic Medicine at the University of Giessen during 2009 and 2010. The age of the individuals measured ranged from 15 to 96 years (mean value 52.8, median 51 years). Of these individuals, 82 were male and 35 were female. The length of the sagittal suture with respect to body length yielded a correlation coefficient of only r = 0.045 (p = 0.617) in the regression analysis. Similar results were found for the coronal suture: In this case the correlation coefficient was r = 0.015. With an assumed maximum permissible probability of error of α = 0.05, none of the performed regression analyses were found to be statistically significant. As expected, our results suggest that neither the length of the sagittal nor the length of the coronal suture is suitable for a forensic estimation of stature for Central European individuals.

  14. Declining tibial curvature parallels ∼6150 years of decreasing mobility in Central European agriculturalists.

    Science.gov (United States)

    Macintosh, Alison A; Davies, Thomas G; Pinhasi, Ron; Stock, Jay T

    2015-06-01

    Long bones respond to mechanical loading through functional adaptation in a suite of morphological characteristics that together ensure structural competence to in vivo loading. As such, adult bone structure is often used to make inferences about past behavior from archaeological remains. However, such biomechanical approaches often investigate change in just one aspect of morphology, typically cross-sectional morphology or trabecular structure. The relationship between longitudinal bone curvature and mobility patterns is less well understood, particularly in the tibia, and it is unknown how tibial curvature and diaphyseal cross-sectional geometry interact to meet the structural requirements of loading. This study examines tibial curvature and its relationship with diaphyseal cross-sectional geometry (CSG) and body size in preindustrial Central Europeans spanning ∼6150 years following the introduction of agriculture in the region. Anteroposterior centroid displacement from the proximo-distal longitudinal axis was quantified at nine diaphyseal section locations (collectively representative of diaphyseal curvature) in 216 tibial three-dimensional laser scans. Results documented significant and corresponding temporal declines in midshaft centroid displacement and CSG properties. Significant correlations were found between mid-diaphyseal centroid displacement and all mobility-related CSG properties, while the relationship weakened toward the diaphyseal ends. No significant relationship was found between centroid displacement and body size variables with the exception of the most distal section location. Results support a relationship between tibial curvature and cross-sectional geometry among prehistoric Central European agricultural populations, and suggest that changes in mechanical loading may have influenced a suite of morphological features related to bone adaptation in the lower limb. © 2015 Wiley Periodicals, Inc.

  15. Assessing Forest Classification in a Landscape-Level Framework: An Example from Central European Forests

    Directory of Open Access Journals (Sweden)

    Antonín Kusbach

    2017-11-01

    Full Text Available Traditional land classifications developed on the basis of what was once prevailing expert knowledge have since largely become obsolete. We assessed expert knowledge based landscape-level units delineated in central European temperate forests: Natural Forest Areas (NFA and Forest Vegetation Zones (FVZ. Our focus was determining to what degree these units reflect vegetation-environmental relationships. After considering as many as 49,000 plots with vegetation and 25,000 plots with environmental data within a territory of the Czech Republic, we analyzed 11,885 plots. We used multivariate statistics to discriminate between the landscape-level units. While NFAs performed extremely well, FVZ results were less successful. Classification of the environment provided better results than classification of vegetation for both the Hercynicum and Carpaticum phytogeographic part of the Czech Republic. Taking into account significance of the environment in our analysis, a delimitation of FVZs and similar vegetation-driven structures worldwide via explicit a priori stratification by tree species without consideration of environmental limits would not be supported by our analysis. We suggest not relying only on vegetation in classification analyses, but also including the significant environmental factors for direct classification of FVZ and units in particular in altered vegetation composition setting such as the central European forests. We propose a novel interpretation of FVZ via appropriate vegetation stratification throughout the environment used in conjunction with the zonal concept. Understanding of coarse-scaled vegetation-environmental relationships is not only fundamental in forest ecology and forest management, but is also essential for improving lower classification levels. Valuable expert knowledge should be combined with formal quantification, which is consistent with recent calls for advanced multidisciplinary ecological classifications in Europe

  16. A cross-sectional survey to evaluate knowledge, attitudes and practices (KAP regarding seasonal influenza vaccination among European travellers to resource-limited destinations

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    Szucs Thomas D

    2010-07-01

    Full Text Available Abstract Background Influenza is one of the most common vaccine-preventable diseases in travellers. By performing two cross-sectional questionnaire surveys during winter 2009 and winter 2010 among European travellers to resource-limited destinations, we aimed to investigate knowledge, attitudes and practices (KAP regarding seasonal influenza vaccination. Methods Questionnaires were distributed in the waiting room to the visitors of the University of Zurich Centre for Travel' Health (CTH in January and February 2009 and January 2010 prior to travel health counselling (CTH09 and CTH10. Questions included demographic data, travel-related characteristics and KAP regarding influenza vaccination. Data were analysed by using SPSS® version 14.0 for Windows. Differences in proportions were compared using the Chi-square test and the significance level was set at p ≤ 0.05. Predictors for seasonal and pandemic influenza vaccination were determined by multiple logistic regression analyses. Results With a response rate of 96.6%, 906 individuals were enrolled and 868 (92.5% provided complete data. Seasonal influenza vaccination coverage was 13.7% (n = 119. Only 43 (14.2% participants were vaccinated against pandemic influenza A/H1N1, mostly having received both vaccines simultaneously, the seasonal and pandemic one. Job-related purposes (44, 37%, age > 64 yrs (25, 21% and recommendations of the family physician (27, 22.7% were the most often reported reasons for being vaccinated. In the multiple logistic regression analyses of the pooled data increasing age (OR = 1.03, 95% CI 1.01 - 1.04, a business trip (OR = 0.39, 95% CI 0.17 - 0.92 and seasonal influenza vaccination in the previous winter seasons (OR = 12.91, 95% CI 8.09 - 20.58 were independent predictors for seasonal influenza vaccination in 2009 or 2010. Influenza vaccination recommended by the family doctor (327, 37.7%, travel to regions with known high risk of influenza (305, 35.1%, and influenza

  17. Study of seismic events in the Central Part of East European Platform

    Science.gov (United States)

    Gorbunova, Ella; Sanina, Irina; Ivanchenko, Galina; Nesterkina, Margarita; Konstantinovskaya, Natalya

    2015-04-01

    A measurement system for location seismic events in the Central Part of East European Platform is situated within the Mikhnevo Geophysical Observatory of the RAS Institute of Geospheres Dynamics and consists of 12 seismic stations. One vertical station is located in the center of the group in a shaft tunnel. The other stations are located on the periphery in three concentric circles and are almost equally spaced with regard to the terrain to ensure full azimuth coverage to the maximum extent possible. The unique array identifies events with a magnitude up to 3 at the distances until 1000 km within the Central Part of East European platform. Most of the events recorded by the Mikhnevo array at a distance of 60-500 km are man-made events represented by explosions in quarries during the development of mineral deposits. Long-term seismic records of explosions in quarries have been processed for the period from 2004 to 2014 to generate a database containing standard waveforms for each quarry. Some events of unknown origin appear in the records for this period; these do not correspond to the identified seismic forms for explosions in known quarries. Epicenter coordinates for these events do not match the coordinates of the known quarries. A cosmotectonic map of the Central Part of East European Platform was compiled during the studies using the LESSA software package (Lineament Extraction and Stripe Statistical Analysis) and data on the deep crustal structure, which made it possible to define the morphostructural plan and evaluate the geodynamic conditions in the area. The deep basement structure through the sedimentary cover is expressed in the surface texture of the area under study. The region's neotectonics is closely related to the history of deep structures, in particular, aulacogens extending in different directions, which may show in the contemporary morphostructural plan, mainly as inversion and partially inherited forms. Out of events of unknown nature

  18. Web of science coverage and scientific performance of Central and Eastern European countries

    Energy Technology Data Exchange (ETDEWEB)

    Ploszaj, A.; Olechnicka, A.

    2016-07-01

    The paper put forward the hypothesis that changes in the list of journals, particularly in the number of periodicals published in specific Central and Eastern European (CEE) countries, have a significant impact on bibliometric indicators and, consequently, on the convergence levels they are used to measure. The analyses presented in the article support the argument that countries from Central and Eastern Europe, despite showing fairly consistent convergence trends, achieve noticeably weaker results than Western Europe regarding research and development and scientific activity. The evident impact made by the inclusion of numerous CEE journals in WoS on the values of the indicator analysed, directly supports the hypothesis put forward in this article. The results of the study are important because data on the number of publications and citations in the Web of Science are increasingly used as development indicators of national R&D sectors. By showing how modifications in these databases influence the results obtained, we can better understand and thus make better use of data from these sources. The article concludes with listing the possibilities for furthering and deepening selected themes pointed out in the paper. (Author)

  19. Rove beetle subtribes Quediina, Amblyopinina and Tanygnathinina: systematic changes affecting Central European fauna (Coleoptera, Staphylinidae, Staphylinini

    Directory of Open Access Journals (Sweden)

    Alexey Solodovnikov

    2012-01-01

    Full Text Available In preparation for the new edition of the identification keys of rove beetles of Central Europe (Volume 4 of the “Die Käfer Mitteleuropas”, the following systematic problems affecting the Central European fauna of the tribe Staphylinini are addressed: phylogeny-based, new concepts for the subtribes Quediina and Amblyopinina; status of the subtribe Tanygnathinina; systematic position of the genus Astrapaeus; status of Quedionuchus, the subgenus of Quedius; identity of some species of Quedius and Heterothops. As a result, new wordwide and Central Europe-based diagnoses are given for the subtribes Quediina and Amblyopinina; earlier recognized but not widely accepted synonymies of the genera Quedius and Velleius, and of the species Heterothops praevius and H. niger, are justified; new synonyms are established for: Quedius pseudonigriceps Reitter, 1909 (= Quedius noricus Bernhauer, 1927, syn. n.; Quedius maurorufus (Gravenhorst, 1806 (= Quedius richteri Korge, 1966, syn. n.; Quedius suturalis Kiesenwetter, 1845 (= Quedius merlini Drugmand et Bruge 1991, syn. n.; lectotypes are designated for Quedius meridiocarpathicus Smetana, 1958, Quedius noricus Bernhauer, 1927, and Quedius pseudonigriceps Reitter, 1909. As a result of synonymy of Quedius and Velleius, the following new combinations are proposed: Quedius amamiensis (Watanabe, 1990, comb. n.; Quedius circumipectus (Cho, 1996, comb. n.; Quedius elongatus (Naomi, 1986, comb. n.; Quedius japonicus (Watanabe, 1990, comb. n.; Quedius pectinatus (Sharp, 1874, comb. n.; Quedius setosus (Sharp, 1889, comb. n.; Quedius simillimus (Fairmaire, 1891, comb. n. As a result of new combinations, Quedius japonicus (Watanabe, 1990 (non Quedius japonicus Sharp, 1874 is replaced with the new name Quedius watanabei Solodovnikov, nom. n., while Quedius pectinatus Lea, 1908 (non Quedius pectinatus (Sharp, 1874 is replaced with the new name Quedius arthuri Solodovnikov, nom. n.

  20. Rove beetle subtribes Quediina, Amblyopinina and Tanygnathinina: systematic changes affecting Central European fauna (Coleoptera, Staphylinidae, Staphylinini).

    Science.gov (United States)

    Solodovnikov, Alexey

    2012-01-01

    In preparation for the new edition of the identification keys of rove beetles of Central Europe (Volume 4 of the "Die Käfer Mitteleuropas"), the following systematic problems affecting the Central European fauna of the tribe Staphylinini are addressed: phylogeny-based, new concepts for the subtribes Quediina and Amblyopinina; status of the subtribe Tanygnathinina; systematic position of the genus Astrapaeus; status of Quedionuchus, the subgenus of Quedius; identity of some species of Quedius and Heterothops. As a result, new wordwide and Central Europe-based diagnoses are given for the subtribes Quediina and Amblyopinina; earlier recognized but not widely accepted synonymies of the genera Quedius and Velleius, and of the species Heterothops praevius and Heterothops niger, are justified; new synonyms are established for: Quedius pseudonigriceps Reitter, 1909 (= Quediusnoricus Bernhauer, 1927, syn. n.); Quedius maurorufus (Gravenhorst, 1806) (= Quedius richteri Korge, 1966, syn. n.); Quedius suturalis Kiesenwetter, 1845 (= Quedius merlini Drugmand & Bruge 1991, syn. n.); lectotypes are designated for Quedius meridiocarpathicus Smetana, 1958, Quedius noricus Bernhauer, 1927, and Quedius pseudonigriceps Reitter, 1909. As a result of synonymy of Quedius and Velleius, the following new combinations are proposed: Quedius amamiensis (Watanabe, 1990), comb. n.; Quedius circumipectus (Cho, 1996), comb. n.; Quedius elongatus (Naomi, 1986), comb. n.; Quedius japonicus (Watanabe, 1990), comb. n.; Quedius pectinatus (Sharp, 1874), comb. n.; Quedius setosus (Sharp, 1889), comb. n.; Quedius simillimus (Fairmaire, 1891), comb. n. As a result of new combinations, Quedius japonicus (Watanabe, 1990) (non Quedius japonicus Sharp, 1874) is replaced with the new name Quedius watanabei Solodovnikov, nom. n., while Quedius pectinatus Lea, 1908 (non Quedius pectinatus (Sharp, 1874)) is replaced with the new name Quedius arthuri Solodovnikov, nom. n.

  1. European Association for Palliative Care: Forging a Vision of Excellence in Palliative Care in Central and Eastern European and Former Soviet Union Countries.

    Science.gov (United States)

    Radbruch, Lukas; Ling, Julie; Hegedus, Katalin; Larkin, Philip

    2018-02-01

    The European Association for Palliative Care (EAPC) represents many thousands of health care workers and volunteers working in or with an interest in palliative care. In 2016, the EAPC has individual members from 48 nations across the world, and collective members from 57 national palliative care associations in 32 European countries. Throughout its history, the EAPC has produced guidance on a range of palliative care issues. The biennial congresses and research congresses and the comprehensive Web site (www.eapcnet.eu) are renowned and well utilized platforms for dissemination and exchange of palliative care information. The EAPC has also published a newsletter specifically for Eastern European and Central Asian countries that has been available in both English and Russian from 2005 to 2012. In addition, for a period of time, a Russian Web site (www.eapcspeaksrussian.eu) was also available. A survey of palliative care in Central and Eastern European nations sponsored by Open Society Foundation's International Palliative Care Initiative found that in most countries, the national language is preferred rather than using English or Russian for the provision of information. Accordingly, the EAPC Web site provides translations of white papers, position papers, and blog posts in a number of languages. Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  2. Il cambio dollaro/euro, il prezzo del petrolio e la Banca Centrale Europea (Dollar/Euro Exchange Rate, Oil Price and the European Central Bank

    Directory of Open Access Journals (Sweden)

    Stefano Sylos Labini

    2012-04-01

    Full Text Available In this paper an analysis on dollar/euro exchange rate, oil price and European Central Bank monetary policy is worked out. Firstly, data on the main variables related with the exchange rate and an equation to explain the variation of the exchange rate in the period March 1998-September 2000 are presented; secondly, the consequences of oil price growth and eurodevaluation on the US and European economies are taken into account; lastly, different policy strategies to stop eurodevaluation are discussed. The European Central Bank strategy, that consists of small increases of the interest rate, is not reaching any result. An alternative strategy is based on innovative public demand, that should be financed by European bonds using "central bank excess funds" as security. Public demand of infrastructures and new technologies should aim at reducing oil dependence and would stimulate growth and sustainable development in Europe, with positive effects on the exchange rate.       JEL Codes: E58, F31Keywords: Devaluation, Exchange Rates, Monetary

  3. Prioritization strategies for pandemic influenza vaccine in 27 countries of the European Union and the Global Health Security Action Group: a review

    Directory of Open Access Journals (Sweden)

    Haas Walter

    2007-09-01

    Full Text Available Abstract Background Although there is rapid progress in vaccine research regarding influenza pandemic vaccines it is expected that pandemic influenza vaccine production can only start once the pandemic virus has been recognized. Therefore, pandemic vaccine capacity will be limited at least during the first phase of an influenza pandemic, requiring vaccine prioritization strategies. WHO recommends developing preliminary priorities for pandemic vaccine use. The goal of this review is to provide a thorough overview of pandemic vaccine prioritization concepts in the 27 European Union (EU member states and the four non-EU countries of the Global Health Security Action Group. Methods Between September and December 2006 data was collected for each country through two data sources: (i the national influenza pandemic plan; (ii contacting key persons involved in pandemic planning by email and/or phone and/or fax Results Twenty-six (84% countries had established at least one vaccine priority group. Most common reported vaccine priority groups were health care workers (HCW (100%, essential service providers (ESP (92% and high risk individuals (HRI (92%. Ranking of at least one vaccine priority group was done by 17 (65% of 26 countries. Fifteen (88% of these 17 countries including a ranking strategy, decided that HCW with close contact to influenza patients should be vaccinated first; in most countries followed and/or ranked equally by ESP and subsequently HRI. Rationales for prioritization were provided by 22 (85% of 26 countries that established vaccine priority groups. There was large variation in the phrasing and level of detailed specification of rationales. Seven (32% of 22 countries providing rationales clearly associated each vaccine priority group with the specific rationale. Ten (32% of the 31 countries studied countries have consulted and involved ethical experts to guide decisions related to vaccine prioritization. Conclusion In the majority of

  4. The impact of a quadrivalent human papillomavirus (types 6, 11, 16, 18) virus-like particle vaccine in European women aged 16 to 24

    DEFF Research Database (Denmark)

    Majewski, S; Bosch, F X; Dillner, J

    2009-01-01

    BACKGROUND: Quadrivalent human papillomavirus (HPV types 6/11/16/18) L1 VLP vaccine is highly effective in preventing HPV 6/11/16/18-related cervical and external genital disease. Herein, we evaluated the impact of the quadrivalent HPV 6/11/16/18 L1 VLP vaccine on prevention of HPV......-associated cervico-genital lesions in a broad population of sexually active European women. METHODS: Female subjects (N = 9265) aged 16-24 with four or fewer lifetime sexual partners were enrolled and randomized to quadrivalent HPV vaccine or placebo. Subjects underwent cervicovaginal sampling for HPV DNA detection....... Papanicolaou testing and anti-HPV 6/11/16/18 serology testing was also performed. RESULTS: Vaccine efficacy against lesions representing immediate cervical cancer precursors (cervical intraepithelial neoplasia grade 2/3 or adenocarcinoma in situ) related to HPV 6/11/16/18 in the per-protocol population was 100...

  5. Money supply growth and inflation – the monetary policy strategy of the European Central Bank

    Directory of Open Access Journals (Sweden)

    Svatopluk Kapounek

    2007-01-01

    Full Text Available The main aim of this article is to find out whether there is a significant relationship between money supply growth and inflation in the Eurozone. For this reason, the monetary policy strategy of the European Central Bank (ECB has been evaluated. Since the establishment of the ECB in January 1999 to May 2003 the ECB‘s monetary policy strategy consisted of three main elements: a quantitative definition of price stability, a prominent role for money in the assessment of risks to price stability (aggregate M3 as a reference value, and a broadly based assessment of the outlook for price developments. Nevertheless, since May 2003 M3 or any other monetary aggregate has lost its prominent role in the ECB‘s strategy. Therefore the nowadays ECB‘s monetary policy strategy consists of a quantitative definition of the primary objective of price stability and an analytical framework based on two pillars – economic analysis and monetary analysis. These two pillars are used by the ECB‘s Governing Council in the overall assessment of risks to price stability and in monetary policy decisions.The empirical part of this article is based on time series correlation between money supply growth and inflation in selected member countries of the Economic and Monetary Union (EMU - Eurozone during the period 1995–2005. The time series are divided into two parts. The first part covers data for selected member countries of the European Union from 1995 till 1998, i.e. before the establishment of the EMU. Whereas the second part includes data for the whole Eurozone since its official start in 1999 to 2005. The time series are adjusted by SARIMA models.

  6. Toward a more professional and practical medical education: a novel Central European approach

    Directory of Open Access Journals (Sweden)

    Drexel H

    2015-06-01

    Full Text Available Heinz Drexel,1–4,* Alexander Vonbank,1–3,* Peter Fraunberger,3,5 Walter F Riesen,3 Christoph H Saely1–3 1Vorarlberg Institute for Vascular Investigation and Treatment, 2Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria; 3Private University of the Principality of Liechtenstein, Triesen, Liechtenstein; 4Drexel University College of Medicine, Philadelphia, PA, USA; 5Medical Central Laboratories, Feldkirch, Austria  *These authors contributed equally to this work Abstract: We here present an innovative curriculum for a complete medical education that conforms to the current European Bologna system of academic training. The curriculum aims at raising doctors who are excellently prepared for clinical work over as short a time as 5 years; it provides a comprehensive, yet shorter than usual, education that strongly pronounces the importance of increasing the students’ practical clinical competences and rigorously excludes superfluous contents. The curriculum encompasses 52 modules, 32 at the bachelor’s and 20 at the master’s level. Already at the level of the bachelor degree, full employability is given; the students finish the master’s course as medical doctors optimally prepared to manage patients at the level of postgraduate medical education. The structure of the curriculum is modular; each modular component is essential for medical education and contains an average of five European Credit Transfer System credits, amounting to 150 hours of education. Depending on the subspecialty, the courses include lectures, seminars, practical laboratory training, and clinical training at varying quantities. In addition to attendance times, sufficient time slots are prepared for self-study in lectures, seminars, and practical work. With our curriculum, we provide an easily applicable backbone for a modern course of medicine that can be installed also at smaller academic institutions. Keywords: Bologna

  7. Combined dendro-documentary evidence of Central European hydroclimatic springtime extremes over the last millennium

    Science.gov (United States)

    Büntgen, Ulf; Brázdil, Rudolf; Heussner, Karl-Uwe; Hofmann, Jutta; Kontic, Raymond; Kyncl, Tomáš; Pfister, Christian; Chromá, Kateřina; Tegel, Willy

    2011-12-01

    A predicted rise in anthropogenic greenhouse gas emissions and associated effects on the Earth's climate system likely imply more frequent and severe weather extremes with alternations in hydroclimatic parameters expected to be most critical for ecosystem functioning, agricultural yield, and human health. Evaluating the return period and amplitude of modern climatic extremes in light of pre-industrial natural changes is, however, limited by generally too short instrumental meteorological observations. Here we introduce and analyze 11,873 annually resolved and absolutely dated ring width measurement series from living and historical fir ( Abies alba Mill.) trees sampled across France, Switzerland, Germany, and the Czech Republic, which continuously span the AD 962-2007 period. Even though a dominant climatic driver of European fir growth was not found, ring width extremes were evidently triggered by anomalous variations in Central European April-June precipitation. Wet conditions were associated with dynamic low-pressure cells, whereas continental-scale droughts coincided with persistent high-pressure between 35 and 55°N. Documentary evidence independently confirms many of the dendro signals over the past millennium, and further provides insight on causes and consequences of ambient weather conditions related to the reconstructed extremes. A fairly uniform distribution of hydroclimatic extremes throughout the Medieval Climate Anomaly, Little Ice Age and Recent Global Warming may question the common believe that frequency and severity of such events closely relates to climate mean stages. This joint dendro-documentary approach not only allows extreme climate conditions of the industrial era to be placed against the backdrop of natural variations, but also probably helps to constrain climate model simulations over exceptional long timescales.

  8. Gender Role Attitudes among Higher Education Students in a Borderland Central-Eastern European Region Called "Partium"

    Science.gov (United States)

    Fényes, Hajnalka

    2014-01-01

    In this paper, we examine the attitudes towards gender roles among higher education students in a borderland Central-Eastern European region. We used the database of "The Impact of Tertiary Education on Regional Development" project (N = 602, 2010). We intend to determine what kind of attitudes towards gender roles the students identify…

  9. Transition in Education: Policy Making and the Key Educational Policy Areas in the Central-European and Baltic Countries.

    Science.gov (United States)

    Rado, Peter

    This report examines transition in educational systems and identifies key policy areas in Central-Eastern European countries. It summarizes policy implications of the transition process within the educational context of these countries. Chapter 1, "Transition and Education," outlines key characteristics of the transition process and…

  10. Causes of the outbreak of the eurozone crises: the role of the USA and the European Central Bank monetary polic

    Directory of Open Access Journals (Sweden)

    Nalia Białek

    2015-10-01

    Full Text Available This paper argues that the loose monetary policy of two of the world’s most important financial institutions—the U.S. Federal Reserve Board and the European Central Bank—were ultimately responsible for the outburst of global financial crisis of 2008-09. Unusually low interest rates in 2001- 05 compelled investors to engage in high risk endeavors. It also encouraged some governments to finance excessive domestic consumption with foreign loans. Emerging financial bubbles burst first in mortgage markets in the U.S. and subsequently spread to other countries. The paper also reviews other causes of the crisis as discussed in literature. Some of them relate directly to weaknesses inherent in the institutional design of the European Monetary Union (EMU while others are unique to members of the EMU. It is rather striking that recommended remedies tend not to take into account the policies of the European Central Bank.

  11. Retracted article: Flexible Fourier Stationary Test in GDP per capita for Central Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Meng-Nan Zhu

    2011-06-01

    Full Text Available Statement of Retraction (http://www.efri.uniri.hr/prikaz.asp?txt_id=7366 This is to notify our respectful reading public that the Editorial Board of the journal Zbornik radova Ekonomskog fakulteta u Rijeci, časopis za ekonomsku teoriju i praksu/ Proceedings of Rijeka Faculty of Economics, Journal of Economics and Business has retracted the following article from publication: “Flexible Fourier Stationary Test in GDP per capita for Central Eastern European Countries“, by Hsu-Ling Chang, Chi-Wei Su, Meng-Nan Zhu, published in our journal Zbornik radova Ekonomskog fakulteta u Rijeci, časopis za ekonomsku teoriju i praksu/ Proceedings of Rijeka Faculty of Economics, Journal of Economics and Business, 2011, vol. 29 (1, pp. 51-63 and almost concurrently published in the journal Eastern European Economics, 2011, vol. 49 (3, pp. 54-65. Being in contact with Josef C Brada, Professor Emeritus, Editor of the journal Eastern European Economics (EEE, we realized that the paper had been sent to both journals, although first published in the EEE and then in our Journal. According to professor Brada’s and our analysis, the paper published in these two journals is exactly the same, except for minor differences in wording, most likely due to editing the text before publication. The outstanding differences are in the title and the fact that the paper published in our Journal has three authors and in EEE journal has two. Whatsoever, owing to the fact that the article had been sent to both journals almost at the same time, it had been impossible to find out the case during the review procedure. Due to this unpleasant situation, our Editorial Board would like to inform our valuable readers that all the necessary measures to retract the paper from our publication have been undertaken and according to publishing ethical principles, cooperation with the authors of the retracted paper have been stopped. Although, in this case neither EEE nor our Journal had any

  12. [Spanish patients with central hypoventilation syndrome included in the European Registry. The 2015 data].

    Science.gov (United States)

    García Teresa, María Angeles; Porto Abal, Raquel; Rodríguez Torres, Silvia; García Urabayen, Diego; García Martínez, Silvia; Trang, Ha; Campos Barros, Angel; Llorente de la Fuente, Ana; Hernández González, Arturo; Bustinza Arriortua, Amaya; de la Cruz Moreno, Jesús; Pons Odena, Martí; Ventura Faci, Purificación; Rubio Ortega, Laura; Pérez Ruiz, Estela; Aguilar Fernández, Antonio; Pérez Ocón, Amaya; Osona, Borja; Delgado Pecellin, Isabel; Arroyo Carrera, Ignacio; Sayas Catalán, Javier; González Salas, Elvira; de Vicente, Carlos Martin

    2017-05-01

    Congenital Central Hypoventilation Syndrome (CCHS) is a very rare genetic disease. In 2012 the European Central Hypoventilation Syndrome (EuCHS) Consortium created an online patient registry in order to improve care. To determine the characteristics and outcomes of Spanish patients with CCHS, and detect clinical areas for improvement. An assessment was made on the data from Spanish patients in the European Registry, updated on December 2015. The Registry contained 38 patients, born between 1987 and 2013, in 18 hospitals. Thirteen (34.2%) were older than 18 years. Three patients had died. Genetic analysis identified PHOX2B mutations in 32 (86.5%) out of 37 patients assessed. The 20/25, 20/26 and 20/27 polyalanine repeat mutations (PARMs) represented 84.3% of all mutations. Longer PARMs had more, as well as more severe, autonomic dysfunctions. Eye diseases were present in 47%, with 16% having Hirschsprung disease, 13% with hypoglycaemia, and 5% with tumours. Thirty patients (79%) required ventilation from the neonatal period onwards, and 8 (21%) later on in life (late onset/presentation). Eight children (21%) were using mask ventilation at the first home discharge. Five of them were infants with neonatal onset, two of them, both having a severe mutation, were switched to tracheostomy after cardiorespiratory arrest at home. Approximately one-third (34.3%) of patients were de-cannulated and switched to mask ventilation at a mean age of 13.7 years. Educational reinforcement was required in 29.4% of children attending school. The implementation of the EuCHS Registry in Spain has identified some relevant issues for optimising healthcare, such as the importance of genetic study for diagnosis and assessment of severity, the high frequency of eye disease and educational reinforcement, as well as some limitations in ventilatory techniques. Copyright © 2016 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  13. DATA ISSUES IN TOTAL FACTOR PRODUCTIVITY BENCHMARKING: A CENTRAL EUROPEAN PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Machek Ondrej

    2012-12-01

    Full Text Available Total factor productivity is a method of measuring overall productivity of businesses, industries or economies. It is an approach which is recently becoming popular among government regulatory agencies when applying the so-called performance-based regulation. This principle induces regulated companies (for instance, electricity or natural gas distributors to behave efficiently even if their industries are not exposed to competitive pressures, since they are rewarded for being more productive than other firms in the industry, and penalized in the opposite case. The aim of this article is to deal with the question what are the main data issues when comparing total factor productivity among firms or industries with focus on the Central European region, which is very heterogeneous in terms of geographic, social, economic and historic conditions. In the first part, we introduce total factor productivity and the most common methods of its measurement � Malmquist and T�rnqvist indexes. Consequently, we divide the data issues into separate categories and discuss them more in detail. The first category of issues is related to defining the set of comparable firms. Many factors, such as the degree of competition in the market, the extent of government regulation, economies of scale, firm size, geographical conditions and historic development have to be taken into consideration. The second category is associated with specifying the time period. TFP estimates should be based on long time series and the period should include the whole business cycle and be representative and exclude extraordinary events. The third group of issues is related to defining and measuring the inputs and outputs. Since a number of difficulties are associated with labor input measurement, it is often included into operating expenditures along with materials and services. The measurement of capital is even more contentious. The outputs should reflect performance

  14. INCA-CE: a Central European initiative in nowcasting severe weather and its applications

    Science.gov (United States)

    Kann, A.; Pistotnik, G.; Bica, B.

    2012-04-01

    The INCA-CE (Integrated Nowcasting through Comprehensive Analysis - Central Europe) project aims at implementing a transnational weather information system as well as applications for different socio-economic sectors to reduce risks of major economic damage and loss of life caused by severe weather. Civil protection and also stakeholders from economic sectors are in a growing need of accurate and reliable short-term weather forecasts. Within INCA-CE, a state-of-the art nowcasting system (INCA) is implemented at weather services throughout the European Union's CE (Central Europe) Programme Area, providing analyses and short term forecasts to the aforementioned end-users. In a coherent approach, the INCA (Integrated Nowcasting through Comprehensive Analysis) system will be adapted for implementation and use in a number of partner countries. Within transregional working groups, the gap between short-term weather information and its downstream activities in hydrological disaster management, civil protection and road management will be bridged and best practice management and measure plans will be produced. A web-based platform for outreach to related socio-economic sectors will initiate and foster a dialogue between weather services and further stakeholders like tourism or the insurance sector, flood authorities for disaster management, and the construction industry for cost-efficient scheduling and planning. Furthermore, the project will produce a compact guideline for policy makers on how to combine structural development aspects with these new features. In the present paper, an outline of the project implementation, a short overview about the INCA system and two case studies on precipitation nowcasts will be given. Moreover, directions for further developments both within the INCA system and the INCA-CE project will be pointed out.

  15. Effector and Central Memory Poly-functional CD4+ and CD8+ T cells are Boosted upon ZOSTAVAX® Vaccination

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    Kalpit A Vora

    2015-10-01

    Full Text Available ZOSTAVAX® is a live attenuated varicella-zoster virus (VZV vaccine that is licensed for the protection of individuals ≥ 50 years against shingles, and its most common complication, post-herpetic neuralgia. While IFN responses increase upon vaccination, the quality of the T cell response has not been elucidated. By using polychromatic flow cytometry, we characterized the breadth, magnitude, and quality of ex vivo CD4+ and CD8+ T cell responses induced 3 – 4 weeks after ZOSTAVAX vaccination of healthy adults. We show, for the first time that the highest frequencies of VZV-specific CD4+ T cells were poly-functional CD154+IFNγ+IL-2+TNFα+ cells, which were boosted upon vaccination. The CD4+ T cells were broadly reactive to several VZV proteins, with IE63 ranking the highest amongst them in the fold-rise of poly-functional cells, followed by IE62, gB, ORF9, and gE. We identified a novel poly-functional ORF9-specific CD8+ T cell population in 62% of the subjects, and these were boosted upon vaccination. Poly-functional CD4+ and CD8+ T cells produced significantly higher levels of IFNγ, IL-2, and TNFα compared to mono-functional cells. After vaccination, a boost in the expression of IFN by poly-functional IE63-and ORF9-specific CD4+ T cells, and IFNγ, IL-2, and TNFα by ORF9-specific poly-functional CD8+ T cells was observed. Responding poly-functional T cells exhibited both effector (CCR7−CD45RA−CD45RO+, and central (CCR7+CD45RA−CD45RO+ memory phenotypes, which expressed comparable levels of cytokines. Altogether, our studies demonstrate that a boost in memory poly-functional CD4+ T cells, and ORF9-specific CD8+ T cells may contribute towards ZOSTAVAX efficacy.

  16. Safety, reactogenicity and immunogenicity of the human rotavirus vaccine in preterm European Infants: a randomized phase IIIb study.

    Science.gov (United States)

    Omenaca, Felix; Sarlangue, Jean; Szenborn, Leszek; Nogueira, Marta; Suryakiran, Pemmaraju V; Smolenov, Igor V; Han, Htay H

    2012-05-01

    Rotavirus disease is more severe in preterm infants than in full-term infants. This study assessed the safety, reactogenicity and immunogenicity of a human rotavirus vaccine, RIX4414, in European preterm infants. A total of 1009 preterm infants were randomized (2:1, vaccine:placebo) and stratified into 2 groups: 20% of early (27-30 weeks, group 1) and 80% of late (31-36 weeks, group 2) gestational age preterm infants in each group. Two doses of RIX4414/placebo were administered to these preterm infants according to the recommended chronologic age for full-term infants with an interval of 30-83 days between doses. Serious adverse events were recorded throughout the study period. Solicited and unsolicited adverse events were recorded for 15 and 31 days post-each dose. Antirotavirus IgA concentrations (enzyme-linked immunosorbent assay cutoff = 20 U/mL) and geometric mean concentration were determined pre-dose 1 and 30-83 days post-dose 2 in a subset of 300 infants. This study is registered with ClinicalTrials.gov, number NCT00420745 (eTrack106481). Serious adverse events were reported at a similar frequency in both groups (P = 0.266). Fifty-seven infants reported at least 1 serious adverse event (5.1% [3.5-7.0] in the RIX4414 group and 6.8% [4.3-10.0] in the placebo group). During the 15-day postvaccination follow-up period, diarrhea, vomiting and fever occurred at a similar frequency in both groups; fever could have been due to concomitant vaccines. Five cases (RIX4414 = 3, Placebo = 2) of rotavirus gastroenteritis were reported. The onset of rotavirus gastroenteritis in the RIX4414 group was 1-5 days after vaccination (vaccine strain identified in all cases) and in the placebo group it was 3-4 days after receiving placebo (wild-type rotavirus identified from both cases). Antirotavirus IgA seroconversion rates at 30-83 days post-dose 2 were 85.7% (79.0-90.9) in the RIX4414 group and 16.0% (8.8-25.9) in the placebo group. Geometric mean concentrations were 202.2 U

  17. Periodic fever syndromes in Eastern and Central European countries: results of a pediatric multinational survey

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    Stefan Mariana

    2010-12-01

    Full Text Available Abstract Objective To analyze the prevalence of diagnosed and suspected autoinflammatory diseases in Eastern and Central European (ECE countries, with a particular interest on the diagnostic facilities in these countries. Methods Two different strategies were used to collect data on patients with periodic fever syndromes from ECE countries- the Eurofever survey and collection of data with the structured questionnaire. Results Data from 35 centers in 14 ECE countries were collected. All together there were 11 patients reported with genetically confirmed familial Mediterranean fever (FMF, 14 with mevalonate-kinase deficiency (MKD, 11 with tumor necrosis factor receptor associated periodic syndrome (TRAPS and 4 with chronic infantile neurological cutaneous and articular syndrome (CINCA. Significantly higher numbers were reported for suspected cases which were not genetically tested. All together there were 49 suspected FMF patients reported, 24 MKD, 16 TRAPS, 7 CINCA and 2 suspected Muckle-Wells syndrome (MWS patients. Conclusions The number of genetically confirmed patients with periodic fever syndromes in ECE countries is very low. In order to identify more patients in the future, it is important to organize educational programs for increasing the knowledge on these diseases and to establish a network for genetic testing of periodic fever syndromes in ECE countries.

  18. TRUST, CORRUPTION, BRIBES AND ECONOMIC DEVELOPMENT IN CENTRAL AND EASTERN EUROPEAN COUNTRIES

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    Ana Iolanda Voda

    2013-12-01

    Full Text Available The evolution of the Western world has drawn on theoretical structures of classical and neoclassical liberalism for its explanatory support and sources of inspiration for centuries. Against this ideological background, institutionalists aim at showing that growth is a process of transformation, a double change: an economic and an institutional one. In this analysis, our purpose is to highlight the importance of informal institutional arrangements and their quality in explaining the disparities of revenues and developments between countries. In our approach, we will consider several indicators meant to highlight various aspects of research. The approach proposed is a transversal-comparative one and static methods pertain to uni- and multivariate analysis. The results obtained suggest the existence of major differences within the Central and East European area as far as informal institutions are concerned; moreover, the analysis conducted confirms the existence of a significant relation between the level of development and the structure of informal arrangements such as: trust level, bribe culture and corruption control.

  19. A two-step multiplex PCR system identifying Central European fish species

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    Johannes Oehm

    2015-12-01

    Full Text Available The morphological identification of fish samples can be difficult, for example, when dealing with eggs, larvae, tissue samples, or dietary samples of piscivores. Hard parts such as otoliths, chewing pads, pharyngeal bones or scales can enable morphological identification if present. However, species-specific identification is often not possible, especially in species-rich groups like the cyprinids. Here, we present a two-step multiplex PCR system, tailored for rapid, sensitive, and specific molecular detection of Central European fish species. It is composed of six assays, covers 79 fish and lamprey species, and enables the identification of 31 species, six genera, two families, two orders, and two fish family clusters. This novel approach is tailored for samples with bad DNA quality and has been successfully applied to identify fish prey in feces of the Eurasian otter, the Common Kingfisher, as well as feces and regurgitated pellets of cormorants. More than 4,000 dietary samples of the latter were collected within a two-year field study in the Alpine foreland. These samples have already been analyzed cost-effectively with the presented approach thus generating a detailed picture of cormorant diet in relation to fish phenology. The high sensitivity and specificity of the multiplex PCR system makes it also suitable for applications outside the field of trophic ecology such as the identification of juvenile fish, environmental monitoring, or environmental DNA studies.

  20. Central and Eastern European Spring Pollen Allergens and Their Expression Analysis—State of the Art

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    Jana Žiarovská

    2016-10-01

    Full Text Available Spring pollinosis has become a part of life for many people throughout the world. A wide range of knowledge about the allergenic potential of individual pollen allergen types is documented well, but the starting point of the pollen allergens expression regulation in plants itself is still not fully answered. Expression analysis of pollen allergens does not yet have any specific protocols or methods developed, despite a very good sequence background available in public bioinformatics databases. However, research in this area of interest has a great application potential for breeding and biotechnology of allergenic plants that may benefit from the knowledge of the expression of allergen coding genes in individual varieties or genotypes. Here, a brief review of up-to-date knowledge about the coding sequences of central and eastern European spring pollen allergens is introduced together with real-time based analysis of the expression of two of the main pollen allergens–PR protein type and profilin type of birch and hazelnut.

  1. Neighborhood environment and walking for transport and recreation in Central European older adults

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    Jana Pelclová

    2012-12-01

    Full Text Available BACKGROUND: Neighborhood environment is an aspect that influences physical activity, mainly walking. Hence, built environment research may help to use environmental and policy strategies to increase physical activity. OBJECTIVE: This cross-sectional study aimed to investigate the association between perceived neighborhood environment and meeting the recommendation of at least 30 minutes of walking 5 or more days a week within active transportation and leisure-time domains in Central European older adults. METHODS: Four hundred and fifty six healthy ambulatory older adults filled out the modified and culturally adapted version of the Neighborhood Environment Walkability Scale (ANEWS for obtaining perceived environment information and the self-administrative long version of the International Physical Activity Questionnaire (IPAQ for assessing physical activity levels. RESULTS: Respondents living in high residential density neighborhoods (OR 1.87, living in flats (OR 2.09 and in location with ≤100,000 inhabitants (OR 1.63 were more likely to meet recommendation within walking for transportation. Owning a dog was associated with meeting recommendation within walking for leisure (OR 1.69. CONCLUSIONS: This study supported the specific impact of environment on meeting PA recommendations within transportation and leisure time walking in older adults. Out of all perceived neighborhood environmental attributes received from ANEWS questionnaire, only high residential density was positively associated with meeting recommendation within total walking and walking for transport.

  2. Central European Free Trade Agreement (CEFTA 2006 - Opportunities, Trade Relation and Evolution of Macedonian Economic Diplomacy

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    Krum Efremov

    2015-07-01

    Full Text Available Main activity in the foreign trade policy of the Republic of Macedonia during the past 10 years was the integration of the country on the Central European Free Trade Agreement – (CEFTA. The reason for this is the expectation that the membership of the Republic of Macedonia in CEFTA will significantly contribute to the continual efforts for strengthening the regional trade cooperation, further liberalisation of foreign trade exchange, and continuation of activities for harmonisation of trade rules with international standards. Additionally, CEFTA 2006 provides a much more comprehensive framework for development of mutual relations and economic cooperation among the countries of South Easte Europe. We will explain the concept of development of economic diplomacy in the Republic of Macedonia as a tool for supporting Macedonian economy. The purpose of these activities is to present the Republic of Macedonia as an attractive destination for foreign investments through the promotion of business advantages, and giving incentive to Macedonian export, as well as through strengthening of the country’s position as a attractive touristic destination.

  3. Breeding Bird Assemblage in a Mosaic of Urbanized Habitats in a Central European City

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    Kopij Grzegorz

    2016-04-01

    Full Text Available There is a lack of data on the population densities of birds breeding in a mosaic of typical urbanized habitats. This study was undertaken to partly fulfil this gap in our knowledge. Counts were conducted in 2008 by means of simplified territory mapping method in a fragment (1197 ha of a large Central European city (Wrocław, SW Poland. In total, 50 bird species were breeding in the study area in 2008. The House Sparrow Passer domesticus, Common Swift Apus apus and Rock Dove comprised about 3/5 of all breeding pairs. The other group of species, each one with a density between 6 and 13 pairs per 100 ha, included seven species, namely the Starling, Sturnus vulgaris, Greenfinch, Carduelis chloris, House Martin, Delichon urbica, Tree Sparrow, Passer montanus, Great Tit, Parus major, Blue Tit, Parus caeruleus, and Jackdaw, Corvus monedula. They comprised together about 1/5. The remaining 40 species nested in a density between 0.1 and 3.5 pairs per 100 ha. The most numerous feeding guild were granivores (53.8% and insectivores (37.9 %. Birds nesting on buildings comprised together 74 % of all breeding pairs. For a few species (Luscinia megarhynchos, Saxicola torquata, Corvus cornix and Turdus pilaris an increase in their numbers in the last three decades has been evidenced.

  4. The legacy of mill dams in central European low-order streams

    Science.gov (United States)

    Larsen, Annegret; Alexander, Fuelling; Larsen, Joshua

    2013-04-01

    Historic dams of largely unknown age are a widespread feature within German 1st to 3rd order streams. It has been proposed that accelerated slope erosion due to deforestation and agricultural land use is the reason for the aggradation of some central European floodplains, however this process only explains the delivery of sediment to these rivers. First results show that valley bottom damming was also a critical mechanism for the effective trapping of this increased sediment load. In this study we determine the onset and magnitude of this first impact of humans on riverscapes as a result of valley bottom damming, and examine the management implications. The extensive sedimentation of loam floodplains was precipitated by dam induced changes to the flow regime, and in turn caused the observed (stratigraphical) change of the channels from multithread to meandering. This floodplain loam also blankets a palaeo-wetland soil, which formed an efficient carbon sink. A modelling approach combined with the quantification of the so stored sediments enables us to predict potentially remobilised sediments after dam-removal.

  5. Retention of 1.2 kbp of 'novel' genomic sequence in two European field isolates and some vaccine strains of Fowlpox virus extends open reading frame fpv241.

    Science.gov (United States)

    Jarmin, Susan A; Manvell, Ruth; Gough, Richard E; Laidlaw, Stephen M; Skinner, Michael A

    2006-12-01

    The emergence of variant fowlpox viruses (FWPVs) and increasing field use of recombinants against avian influenza H5N1 emphasize the need to monitor vaccines and to distinguish them from field strains. Five commercial vaccines, two laboratory viruses and two European field isolates were characterized by PCR and sequencing at 18 loci differing between attenuated FP9 and its pathogenic progenitor. PCR failed to discriminate between the viruses and sequence determination revealed no significant differences at any locus, except for a polymorphic locus encompassed by deletion 24 (9.3 kbp) in FP9. Surprisingly, 'novel' previously unreported sequence (spanning 1.2 kbp) was found in both European field isolates and three of the vaccines. It was absent from the other two vaccines, removed by a 1.2 kbp deletion identical to that surprisingly also observed in the completely sequenced genome of FPV USDA. This locus (H9) adds a potentially useful tool for discriminating between FWPV field isolates and vaccines.

  6. The Central and Eastern European Earthquake Research Network - CE3RN

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    Bragato, Pier Luigi; Costa, Giovanni; Gallo, Antonella; Gosar, Andrej; Horn, Nikolaus; Lenhardt, Wolfgang; Mucciarelli, Marco; Pesaresi, Damiano; Steiner, Rudolf; Suhadolc, Peter; Tiberi, Lara; Živčić, Mladen; Zoppé, Giuliana

    2014-05-01

    The region of the Central and Eastern Europe is an area characterised by a relatively high seismicity. The active seismogenic structures and the related potentially destructive events are located in the proximity of the political boundaries between several countries existing in the area. An example is the seismic region between the NE Italy (FVG, Trentino-Alto Adige and Veneto), Austria (Tyrol, Carinthia) and Slovenia. So when a destructive earthquake occurs in the area, all the three countries are involved. In the year 2001 the Agencija Republike Slovenije za Okolje (ARSO) in Slovenia, the Department of Mathematics and Geoscience of the University of Trieste (DMG), the OGS (Istituto Nazionale di Oceanografia e di Geofisica Sperimentale) in Italy and the Zentralanstalt für Meteorologie und Geodynamik (ZAMG) in Austria signed an agreement for the real-time seismological data exchange in the Southeastern Alps region. Soon after the Interreg IIIa Italia-Austria projects "Trans-National Seismological Networks in the South-Eastern Alps" and "FASTLINK" started. The main goal of these projects was the creation of a transfrontier network for the common seismic monitoring of the region for scientific and civil defense purposes. During these years the high quality data recorded by the transfrontier network has been used, by the involved institutions, for their scientific research, for institutional activities and for the civil defense services. Several common international projects have been realized with success. The instrumentation has been continuously upgraded, the installations quality improved as well as the data transmission efficiency. In the 2013 ARSO, DMG, OGS and ZAMG decided to name the cooperative network "Central and Eastern European Earthquake Research Network - CE3RN". The national/regional seismic networks actually involved in the CE3RN network are: • Austrian national BB network (ZAMG - OE) • Friuli Veneto SP network (OGS - FV) • Friuli VG

  7. European Integration and the Transition of Eastern European States. The New Central Europe and Romania's Interest in Regional Cooperation in the Black Sea - Danube Region

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    Flore POP

    2003-01-01

    Full Text Available This short article presents the most important directions of the evolution of Central and Eastern Europe during the second half of the 20th century during the period marked by the coming into power and then the downfall of the communism. One could also note that the Central and Eastern European countries have undergone several political and economic transitions- and for Romania’s case- the burdening heritage of the austerity economic policy that has been implemented during the years will affect the economic development of the countries on the long term. The transition towards market economy was realized upon the political decision of political accession to the free market principle. The new beginning of the regional integration process made the countries in the Danube-Black Sea region, sign new agreements for political and economic cooperation. The emergence of new countries on European and Asian maps opens new opportunities for regional cooperation, especially for environmental issues, which brings new dimensions for the global process of European integration and of the integration of the regional economies into the global economies.

  8. Unequal access to vaccines in the WHO European Region during the A(H1N1) influenza pandemic in 2009.

    Science.gov (United States)

    Jorgensen, Pernille; Wasley, Annemarie; Mereckiene, Jolita; Cotter, Suzanne; Weber, J Todd; Brown, Caroline Sarah

    2013-08-28

    In a severe pandemic, rapid production and deployment of vaccines will potentially be critical in mitigating the impact on populations and essential services. We compared access to vaccines and timing of delivery relative to identification of A(H1N1)pdm09 and the geographic progression of the pandemic in the WHO European Region in order to identify gaps in provision. Information on vaccine procurement and donations was collected through a web-based survey conducted in all 53 member states of the Region. Among the 51 countries responding to the survey, the majority (84%) implemented vaccination campaigns against A(H1N1)pdm09. However, time of vaccine receipt and number of doses varied substantially across the region, with delayed access in many countries especially in those in the lowest income range. Improving access to influenza vaccines in low resource countries and solving issues of product liability should help reduce inequalities and operational challenges arising during a future public health crisis. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Spatial distribution of caesium-137 in soil cover of background terrestrial ecosystems, Central European Russia

    Energy Technology Data Exchange (ETDEWEB)

    Paramonova, Tatiana A. [Radioecology and Ecotoxicology Department of Soil Science Faculty, Moscow State Lomonosov University, 119234 Moscow (Russian Federation); Shamshurina, Evgenia N. [Laboratory of soil erosion and fluvial processes of Geography Faculty, Moscow State Lomonosov University, 119234 Moscow (Russian Federation)

    2014-07-01

    ¹³⁷Cs - the main long-living anthropogenic radionuclide - arrived in mass at Russian terrestrial ecosystems after nuclear tests in the atmosphere in 1960-yy. and after Chernobyl accident in 1986 y., but in spite of a long period since these events soil cover contamination by ¹³⁷Cs is considered as extremely resistant due to its firmly fixation by soil solid matter and a long half-life of the radionuclide. Wide-scale investigation in maximal diversity of natural, semi-natural and anthropogenic landscapes of Central European Russia (more than 400 soils samples from Vologda, Yaroslavl, Ivanovo, Tver regions which are representative for the southern taiga zone) demonstrates that modern average specific activity of ¹³⁷Cs in the upper 15-cm layer of soil is 11±3 Bq/kg (contamination density 0.05±0.01 Ci/km²), that is fully ecologically acceptable. It is important that the average concentrations of ¹³⁷Cs in the soil cover of individual regions are close to each other. The most likely these average values are approximate assessment of background radioactive contamination of soils in central European Russia outside of the immediate Chernobyl trace. At the same time approximately 3% of soils are characterized by elevated ¹³⁷Cs content - 62-98 Bq/kg (0.24-0.43 Ci/km²), that indicates the presence of low radioactive spots on the territory and may be considered as local Chernobyl fallout. All of them attribute with forest soils which are commonly characterized by considerably more high accumulation of ¹³⁷Cs (18±5 Bq/kg, 0.06±0.01 Ci/km²) due to advanced absorbing surface of trees. Agricultural lands (plagued or under meadows) and soils of industrial plots with scarce vegetation contain only 6±2 Bq/kg (0.03±0.01 Ci/km²) of ¹³⁷Cs. About 84-92% of ¹³⁷Cs are concentrated in the upper 15-cm layer of natural soils or in Ap horizon of plagued soils, thus vertical migration of radionuclide is very slow in spite of ~30 years after Chernobyl

  10. Mercury in the central European lake district - case study Plešné lake

    Science.gov (United States)

    Navratil, Tomas; Rohovec, Jan; Novakova, Tereza; Matouskova, Sarka; Kopacek, Jiri; Kana, Jiri

    2017-04-01

    The central European lake district extends within the Bohemian forest and Bavarian forest Mountains. It includes 8 glacial lakes extending in altitudes from 935 to 1087 m a.s.l. All of them have been oligotrophic and forests of the lake catchments are dominated by Norway spruce (Picea abies). Plešné lake (PL) catchment is at 1087 m .a.s.l. and it covers area of 0.67 km2. In 2004, the forest at PL catchment was infested by the bark beetle (Ips typographus) and 88%-99% of trees had died by 2011. In contrast to relatively detailed research of North American and Scandinavian lake ecosystems the information concerning Hg contamination of central European lake ecosystems are rather scarce. The PL ecosystem can provide base for assessment of Hg contamination as well as for changes induced by the bark beetle infestation. In 2016, mean annual Hg concentration in bulk precipitation at Plešné lake reached 3.0 ng/L and bulk Hg deposition flux amounted at 4.6 µg/m2. The most important pathway of Hg deposition to the forest ecosystems has been litterfall. The highest Hg concentrations in litterfall material at PL were found in lichens 205 µg/kg, mixture of unidentifiable organic debris 159 µg/kg and bark 123 µg/kg. Litterfall spruce needles averaged at 56 µg/kg, only. Removal of spruce due to bark beetle infestation caused decrease of litterfall Hg fluxes. Recent litterfall fluxes in the unimpacted stands reached 55.8 µg/m2, while in the impacted dead stands they amounted 23.0 µg/m2, only. The qualitative composition of the litterfall in the infested stands was typical with absence of needles and prevalence of twigs and bark. To assess changes in Hg distribution within the soil profile due to forest dieback the soil data from year 1999 were compared with 2015 data. The mean Hg concentrations in the O horizons decreased from 424 to 311 µg/kg between years 1999 and 2015, and in A horizons the situation was reversed and an increase from 353 to 501 µg/kg occurred. The

  11. On the long-term impact of emissions from central European cities on regional air quality

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    P. Huszar

    2016-02-01

    Full Text Available For the purpose of qualifying and quantifying the impact of urban emission from Central European cities on the present-day regional air quality, the regional climate model RegCM4.2 was coupled with the chemistry transport model CAMx, including two-way interactions. A series of simulations was carried out for the 2001–2010 period either with all urban emissions included (base case or without considering urban emissions. Further, the sensitivity of ozone production to urban emissions was examined by performing reduction experiments with −20 % emission perturbation of NOx and/or non-methane volatile organic compounds (NMVOC. The modeling system's air quality related outputs were evaluated using AirBase, and EMEP surface measurements showed reasonable reproduction of the monthly variation for ozone (O3, but the annual cycle of nitrogen dioxide (NO2 and sulfur dioxide (SO2 is more biased. In terms of hourly correlations, values achieved for ozone and NO2 are 0.5–0.8 and 0.4–0.6, but SO2 is poorly or not correlated at all with measurements (r around 0.2–0.5. The modeled fine particulates (PM2.5 are usually underestimated, especially in winter, mainly due to underestimation of nitrates and carbonaceous aerosols. European air quality measures were chosen as metrics describing the cities emission impact on regional air pollution. Due to urban emissions, significant ozone titration occurs over cities while over rural areas remote from cities, ozone production is modeled, mainly in terms of number of exceedances and accumulated exceedances over the threshold of 40 ppbv. Urban NOx, SO2 and PM2.5 emissions also significantly contribute to concentrations in the cities themselves (up to 50–70 % for NOx and SO2, and up to 60 % for PM2.5, but the contribution is large over rural areas as well (10–20 %. Although air pollution over cities is largely determined by the local urban emissions, considerable (often a few tens of % fraction of the

  12. Central European high-resolution gridded daily data sets (HYRAS: Mean temperature and relative humidity

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    Claudia Frick

    Full Text Available High-resolution (5×5km2$5\\times5\\,\\text{km}^2$ gridded daily data sets of surface air temperature (DWD/BfG-HYRAS-TAS and relative humidity (DWD/BfG-HYRAS-HURS are presented in this study. The data sets cover Germany and the bordering river catchments and last from 1951 to 2006. Their data bases consist of daily station observations from Austria, Belgium, Czech Republic, France, Germany, Luxembourg, the Netherlands and Switzerland. The interpolation of the measurement data to the regular grid is performed using a method based upon Optimal Interpolation. A first climatological analysis for Germany and Central European river catchments of first and second order is performed. For the Rhine river catchment a summer mean temperature of 16.1 °C and relative humidity of 74 % are found. In contrast, the mean temperature of heat summer 2003 amounts to 19.9 °C with a related relative humidity of 65 % in this river catchment. The extreme character of this summer is also remarkable in the presented climate indices, e.g., the increased amount of summer hot days. The first validations of both data sets reveal a bias within the range of the provided data precisions. In addition, an elevation dependency of error scores is identified for temperature. Error scores increase with an increasing station height because height differences between station and grid cell increases with height. A comparison of HYRAS-TAS to another gridded temperature data set reveals a good agreement with again fewer differences at lower altitudes. The presented DWD/BfG-HYRAS data sets have a high spatial and temporal resolution which is unique for Germany and the bordering river catchments so far. They have a high potential for detailed studies of smaller scale structures in Central Europe and are already used as input for hydrological impact modelling, as climatological reference and for bias correction of regional climate models within the German research project KLIWAS

  13. The potential of gamma-ray spectrometry as supplementary information for mapping central European soils

    Science.gov (United States)

    Schuler, U.; Bock, M.; Baritz, R.; Willer, J.; Pickert, E.; Kardel, K.; Herrmann, L.

    2012-04-01

    Permanently updated soil maps are needed inter alia for the prediction of landslide hazards, flooding and drought effects, land degradation monitoring, and precision farming. Since comprehensive and intensive field mapping is not affordable, alternative mapping approaches are required. A promising tool, with quite unrecognised potential for modern soil science is gamma-ray spectrometry. As the radioelements potassium, thorium and uranium respond differently to soil forming processes, it should be possible to infer from their concentration on weathering status, and after calibration on soil properties and types. This paper aims to investigate the potential of airborne gamma spectrometry for mapping of central European soils and soil properties. The study was conducted for a test site in Southern Saxony, Germany, 140*85 km wide, representing diverse soil landscapes. Seven different petrographic training and validation areas were chosen each. To assess the potential of gamma-ray spectrometry as additional data layer, predictions were carried out (i) with and (ii) without radiometric data. The outputs were compared with independent soil information of the validation areas. Both prediction runs used the following predictors: elevation, slope, curvature, planform curvature, profile curvature, terrain ruggedness index, relative altitude, vertical distance above drainage network, wetness index, and convergence index. As additional predictor parent material derived from a reclassification of the official geological map (1:1M scale) was used. As radiometric properties potassium, thorium and uranium were used. The radiometric raster datasets were generated by universal kriging using relative altitude as covariate. Training and validation datasets were selected from a comprehensive dataset representing more than 14.000 point data. Point data include soil types and substrates, and for more than 800 sites soil profiles with analysed texture, pH, exchangeable cations, nutrients

  14. The influence of management on GHG fluxes over Central European grasslands

    Science.gov (United States)

    Hoertnagl, Lukas; Bahn, Michael; Buchmann, Nina; Dias-Pinez, Eugenio; Eugster, Werner; Kiese, Ralf; Klumpp, Katja; Thomas, Ladreiter-Knauss; Lu, Haiyan; Wohlfahrt, Georg; Zeeman, Matthias; Merbold, Lutz

    2016-04-01

    Central European grasslands are characterized by a wide range of different agricultural practices along an altitudinal and management gradient, reaching from low pastures and meadows up to high alpine grasslands above the tree line. In the future, the intensification of already available agricultural land as a consequence of increased demand for feed and food will play an important role because of the scarcity of unused, productive land. The land use intensity strongly affects the exchange of trace gases between the biosphere and atmosphere. Therefore, the greenhouse gas (GHG) reduction potential for different farming strategies needs to be quantified before effective greenhouse gas mitigation strategies can be introduced. Direct measurements of long-term grassland GHG exchange at ecosystem scale along altitudinal and management gradients can help in identifying key processes that lead to GHG emissions. In this synthesis we investigated GHG fluxes with a focus on N2O and CH4 from 15 grassland sites, quantified by means of the eddy covariance or chamber technique. Grasslands were a source of N2O, with the exception of one abandoned site, while they were a source or small sink for CH4. The predictive power of soil temperature and water-filled pore space for N2O and CH4 flux patterns during snow-free time periods in-between management events was generally low but varied considerably across the year. However, setting fluxes in relation to classes of the two soil parameters revealed favorable conditions ('sweet spots') for N2O and CH4 emissions for some sites. In addition, fertilization had a clear impact on N2O and CH4 fluxes, with emission peaks on the day of fertilization or one day later. N2O-N emission factors at fertilized sites were found to be slightly higher than the IPCC Tier 1 approach, ranging between 1.31 and 1.53 %, depending on the gap-filling method to calculate yearly cumulative N2O emissions.

  15. Mycorrhizas in the Central European flora: relationships with plant life history traits and ecology.

    Science.gov (United States)

    Hempel, Stefan; Götzenberger, Lars; Kühn, Ingolf; Michalski, Stefan G; Rillig, Matthias C; Zobel, Martin; Moora, Mari

    2013-06-01

    Plant traits have been widely used to characterize different aspects of the ecology of plant species. Despite its wide distribution and its proven significance at the level of individuals, communities, and populations, the ability to form mycorrhizal associations has been largely neglected in these studies so far. Analyzing plant traits associated with the occurrence of mycorrhizas in plants can therefore enhance our understanding of plant strategies and distributions. Using a comparative approach, we tested for associations between mycorrhizal status and habitat characteristics, life history traits, and plant distribution patterns in 1752 species of the German flora (a major part of the Central European flora). Data were analyzed using log-linear models or generalized linear models, both accounting for phylogenetic relationships. Obligatorily mycorrhizal (OM) species tended to be positively associated with higher temperature, drier habitats, and higher pH; and negatively associated with moist, acidic, and fertile soils. Competitive species were more frequently OM, and stress tolerators were non-mycorrhizal (NM), while ruderal species did not show any preference. Facultatively mycorrhizal (FM) species showed the widest geographic and ecological amplitude. Indigenous species were more frequently FM and neophytes (recent aliens) more frequently OM than expected. FM species differed markedly from OM and NM species in almost all analyzed traits. Specifically, they showed a wider geographic distribution and ecological niche. Our study of the relationships between mycorrhizal status and other plant traits provides a comprehensive test of existing hypotheses and reveals novel patterns. The clear distinction between FM and OM + NM species in terms of their ecology opens up a new field of research in plant-mycorrhizal ecology.

  16. Identification and interaction of multiple stressors in central European lowland rivers.

    Science.gov (United States)

    Lemm, Jan U; Feld, Christian K

    2017-12-15

    Interactions of multiple stressors in lotic systems have received growing interest and have been analysed in a growing number of studies using experiment and survey data. In this study, we present a protocol to identify, display and analyse stressors of rivers and their interactions (additive, synergistic or antagonistic). We used a dataset of 125 samples of central European lowland rivers comprising hydromorphological, physico-chemical and land use stressor and pressure variables as well as benthic macroinvertebrate traits as biological response variables. To identify and visualise multiple stressor combinations jointly operating in the data set, we applied social network analysis. The main co-occurring stressor combination was fine sediment accumulation (hydromorphological stress) and enhanced phosphorus concentration (nutrient stress). Agricultural (cropland) and urban land use were identified as the main large scale environmental pressures. Stressor interactions were analysed using generalised linear regression modelling (GLM) including pairwise interaction terms. Altogether, 14 macroinvertebrate response variables were tested on six stressor combinations and revealed predominantly additive effects (80% of all significant models with absolute standardised effect sizes >0.1). Significant antagonistic and synergistic interactions occurred in almost 20% of the models. Fine sediment stress was more influential and frequent than nutrient stress. The methodology presented here is standardisable and thus could help inform practitioners in aquatic ecosystem monitoring about prominent combinations of multiple stressors and their interactions. Yet, further understanding of the mechanisms behind the biological responses is required to be able to derive appropriate guidance for management. This applies to rather complex stressors and pressures, such as land use, for which more detailed data (e.g. nutrient concentrations, fine sediment entry, pesticide pollution) is often

  17. Establishment and work of ethics committees in central and eastern European countries.

    Science.gov (United States)

    Glasa, Jozef

    2002-01-01

    The genuine reform efforts in medicine and health care in Central and East European (CEE) countries have continued to pose important and thought-provoking challenges to the newly reborn disciplines of medical ethics (or bioethics). They are embodied in the bulk of new ethical problems, concepts and quandaries brought about by the developments, changes, clashes, and "real life" issues of the CEE countries' health care systems and biomedical sciences. Certain part, quite variable from country to country, of this bio-ethical endeavour has been confined to the work and activities of ethics committees (ECs) or similar bodies. They have emerged in varying number, shape, composition, competence, legal status, responsibility and time of appearance, in almost all transition countries of CEE. They may be considered as a kind of "field workplaces" of medical ethics/bioethics within the countries' HCSs or biomedical research structures. Despite some shortcomings and drawbacks, a lot has already been achieved. In some countries the progress has been quick and systematic. The major pitfalls were mostly due to the missing, weak or unclear legal backing of ECs' establishment and work; lack of education and training of their members; insufficient support from health care administrators; misconceptions concerning their mission, procedures, scope of responsibility, and reporting; insufficient or missing funding; low profile societal esteem for ECs' work; but some drawbacks were due also to the underdeveloped 'dialogic' culture of the impartial discussion and democratic discourse in the 'post-totalitarian' CEE transition countries. The future of ECs in CEE will be connected to the countries' integration and harmonization efforts towards research, health systems, and other international structures in Europe and beyond. This should need an extensive and non-discriminatory international partnership, exchange and co-operation.

  18. Charlemagne's summit canal: an early medieval hydro-engineering project for passing the Central European Watershed.

    Directory of Open Access Journals (Sweden)

    Christoph Zielhofer

    Full Text Available The Central European Watershed divides the Rhine-Main catchment and the Danube catchment. In the Early Medieval period, when ships were important means of transportation, Charlemagne decided to link both catchments by the construction of a canal connecting the Schwabian Rezat and the Altmühl rivers. The artificial waterway would provide a continuous inland navigation route from the North Sea to the Black Sea. The shortcut is known as Fossa Carolina and represents one of the most important Early Medieval engineering achievements in Europe. Despite the important geostrategic relevance of the construction it is not clarified whether the canal was actually used as a navigation waterway. We present new geophysical data and in situ findings from the trench fills that prove for the first time a total length of the constructed Carolingian canal of at least 2300 metres. We have evidence for a conceptual width of the artificial water course between 5 and 6 metres and a water depth of at least 60 to 80 cm. This allows a crossing way passage of Carolingian cargo scows with a payload of several tons. There is strong evidence for clayey to silty layers in the trench fills which reveal suspension load limited stillwater deposition and, therefore, the evidence of former Carolingian and post-Carolingian ponds. These findings are strongly supported by numerous sapropel layers within the trench fills. Our results presented in this study indicate an extraordinarily advanced construction level of the known course of the canal. Here, the excavated levels of Carolingian trench bottoms were generally sufficient for the efficient construction of stepped ponds and prove a final concept for a summit canal. We have evidence for the artificial Carolingian dislocation of the watershed and assume a sophisticated Early Medieval hydrological engineering concept for supplying the summit of the canal with adequate water.

  19. Pollen limitation is not the rule in nival plants: A study from the European Central Alps.

    Science.gov (United States)

    Wagner, Johanna; Lechleitner, Martin; Hosp, Daniela

    2016-03-01

    Seed output of high-mountain plants in the uppermost life zones is highly variable. One possible reason might be pollen limitation due to inadequate pollinator services. We tested this hypothesis for the insect-pollinated species Cerastium uniflorum, Ranunculus glacialis, and Saxifraga bryoides, which have their distribution center in the subnival and nival zone of the European Central Alps. We recorded insect visitors and determined their impact as pollinators. By analyzing pollination success and seed set following natural and saturating hand pollination, the magnitude of quantitative and qualitative pollen limitation was assessed. Anthomyiid and muscid flies had the highest pollination impact for R. glacialis and S. bryoides and syrphids for C. uniflorum. Natural stigma pollen load was highly variable in individual flowers of all species, but in most cases the number of conspecific pollen grains clearly exceeded the number of ovules to be fertilized. There was also a surplus in germinated pollen grains, whereas the pollen tube to ovule ratio was only sufficient in R. glacialis (2.6 on average) and S. bryoides (1.3), but not in C. uniflorum (0.6). Accordingly, seed to ovule ratio was around 0.8 in R. glacialis, 0.7 in S. bryoides but 0.4 in C. uniflorum. In C. uniflorum, saturating pollination slightly increased seed set. Regression analyses revealed that natural pollination success was more frequently limited by quality than by quantity. Our results do not support the idea of chronic, widespread pollen limitation in the subnival but rather fit into the concept of parental optimism by overinvesting in the number of ovules as an adaptation to variable resource availability. © 2016 Botanical Society of America.

  20. Management effectiveness and land cover change in dynamic cultural landscapes-assessing a central European biosphere reserve

    DEFF Research Database (Denmark)

    Ohnesorge, B.; Plieninger, Tobias; Hostert, P.

    2013-01-01

    Protected areas are a central pillar of efforts to safeguard biodiversity and ecosystem services, but their contribution to the conservation and management of European cultural landscapes that have complex spatial-temporal dynamics is unclear. The conservation strategy of biosphere reserves aims...... to assess the effectiveness of Central European reserves in meeting their land cover related management goals. Based on digital biotope maps, we defined and assessed land cover change processes that were relevant to the reserve management's goals over a period of 13 years. We then compared these changes...... 85% across all zones-differences in land cover changes can be more prominent across zones inside the reserve than between the areas inside and outside of it. The reserve as a whole performed better than the surrounding reference area when using land cover related management goals as a benchmark...

  1. Speciated mercury measurements in ambient air from 2009 to 2011 at a Central European rural background monitoring site

    Directory of Open Access Journals (Sweden)

    Weigelt A.

    2013-04-01

    Full Text Available Since January 2009 highly time-resolved mercury speciation measurements in ambient air are carried out at the Central European German EMEP monitoring station and measurement site of the German Federal Environment Agency “Waldhof“, providing the longest Central European dataset for mercury species. First statistical analyses do not indicate long term trends for the concentrations of gaseous elemental mercury (GEM and particle bound mercury (TPM. A potential increasing trend for reactive gaseous mercury (RGM will have to be verified in the coming years and should be regarded as indicative only at present. A seasonal cycle for TPM could be observed with higher concentrations during winter time. Furthermore a diurnal cycle for RGM is apparent with highest concentrations in the early afternoon.

  2. A decade of proteomics accomplished! Central and Eastern European Proteomic Conference (CEEPC) celebrates its 10th Anniversary in Budapest, Hungary.

    Science.gov (United States)

    Gadher, Suresh Jivan; Drahos, László; Vékey, Károly; Kovarova, Hana

    2017-07-01

    The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe and these series of conferences have become a well-recognized event in the proteomic calendar. Fresher challenges and global healthcare issues such as ageing and chronic diseases are driving clinical and scientific research towards regenerative, reparative and personalized medicine. To this end, proteomics may enable diverse intertwining research fields to reach their end goals. CEEPC will endeavor to facilitate these goals.

  3. The Relationship between Youth Unemployment and Economic Growth in Central and Eastern European Countries: An Empirical Analysis

    OpenAIRE

    Erdal, Leman; İsmet GÖÇER

    2015-01-01

    The study has analyzed the relationship between youth unemployment and economic growth, in the context of Okun law, by using new generation panel data analysis and cointegration tests. In this study, 18 Central and Eastern European country have been selected as subject matter whose youth unemployment rate is above the EU-28 average (25 %) for the period 2006-2012. The results show that, if youth unemployment is quite severe; even an exclusive economic growth will not be enough to reduce the y...

  4. Calculation of carbon emission resulting from poultry production under the conditions of the Central Region in European Russia

    OpenAIRE

    САМАРДЖИЧ МИЛЬЯН; КАСТАЛДИ СИМОНА; ВАЛЕНТИНИ РИККАРДО; ВАСЕНЕВ ИВАН ИВАНОВИЧ

    2014-01-01

    This paper is dedicated to the development and testing of the integral methods of calculation for greenhouse gas emissions estimation at key stages of the production and consumption of poultry meat under the conditions of the Central Region of European Russia. Five phases of the life cycle analysis are discussed from the feed production up to final consumption and waste disposal. Algorithms and examples of the specific greenhouse gas emissions calculation at all stages of the life cycle of po...

  5. Mass incarceration can explain population increases in TB and multidrug-resistant TB in European and central Asian countries.

    Science.gov (United States)

    Stuckler, David; Basu, Sanjay; McKee, Martin; King, Lawrence

    2008-09-09

    Several microlevel studies have pinpointed prisons as an important site for tuberculosis (TB) and multidrug-resistant TB in European and central Asian countries. To date, no comparative analyses have examined whether rises in incarceration rates can account for puzzling differences in TB trends among overall populations. Using longitudinal TB and cross-sectional multidrug-resistant TB data for 26 eastern European and central Asian countries, we examined whether and to what degree increases in incarceration account for differences in population TB and multidrug-resistant TB burdens. We find that each percentage point increase in incarceration rates relates to an increased TB incidence of 0.34% (population attributable risk, 95% C.I.: 0.10-0.58%, P incarceration account for a 20.5% increase in TB incidence or nearly three-fifths of the average total increase in TB incidence in the countries studied from 1991 to 2002. Although the number of prisoners is a significant determinant of differences in TB incidence and multidrug-resistant TB prevalence among countries, the rate of prison growth is a larger determinant of these outcomes, and its effect is exacerbated but not confounded by HIV. Differences in incarceration rates are a major determinant of differences in population TB outcomes among eastern European and central Asian countries, and treatment expansion alone does not appear to resolve the effect of mass incarceration on TB incidence.

  6. Early Holocene vegetation - climate interactions in the central part of European Russia

    Science.gov (United States)

    Novenko, Elena; Olchev, Alexander

    2017-04-01

    The new Early Holocene vegetation and climate reconstruction (approximately 10100 -7800 cal. yr. BP) for the forest zone the central European Russia are based on pollen records from three key regions located in taiga, mixed coniferous-broadleaved and broadleaved forest zones. The climatic parameters (the mean annual temperature and precipitation) and total forest coverage during the early Holocene were reconstructed using the Best Modern Analogue technique. Information about moistening conditions was revealed from reconstructions of actual evapotranspiration (ET) and potential evaporation (PET). For calculation of the annual ET and PET rates of the forest landscapes a regression model was applied. The model is based on nonlinear approximations of annual values of ET and PET provided by the Levenberg-Marquardt method using the results of numerical simulations of ET and PET carried out by a Mixfor-SVAT model for the forests with different species compositions under various thermal and moistening conditions. Mixfor-SVAT is an one-dimensional model of the energy, H2O and CO2 exchange between vertically structured mono- and multi-specific forest stands and the atmosphere (Olchev et al., 2002). Obtained results showed that the considered period was characterized by relatively low air temperatures and high precipitation compared with modern conditions. Analysis of the long-term pattern of the mean annual temperature for all three regions reveal two synchronous significant cooling periods observed in 9100-9300 cal. yr. BP and 8100-8500 cal. yr. BP as well as rapid growth of the air temperature in 8100-7800 cal. yr. BP, when the annual temperatures increased by 3°C during about 300 years. The cooling phase of 8100-8500 cal. yr. BP could be corresponded to the distinct "8.2 ka event" widely recorded across Europe. Periods of climate warming are coincided with periods of precipitation rise whereas the cool phases are characterized by its decrease. The lowest ET and PET rates

  7. Pricing and Reimbursement of Biosimilars in Central and Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Paweł Kawalec

    2017-06-01

    Full Text Available Objectives: The aim of this study was to review the requirements for the reimbursement of biosimilars and to compare the reimbursement status, market share, and reimbursement costs of biosimilars in selected Central and Eastern European (CEE countries.Methods: A questionnaire-based survey was conducted between November 2016 and January 2017 among experts from the following CEE countries: Bulgaria, Czech Republic, Croatia, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia, and Romania. The requirements for the pricing and reimbursement of biosimilars were reviewed for each country. Data on the extent of reimbursement of biologic drugs (separately for original products and biosimilars in the years 2014 and 2015 were also collected for each country, along with data on the total pharmaceutical and total public health care budgets.Results: Our survey revealed that no specific criteria were applied for the pricing and reimbursement of biosimilars in the selected CEE countries; the price of biosimilars was usually reduced compared with original drugs and specific price discounts were common. Substitution and interchangeability were generally allowed, although in most countries they were at the discretion of the physician after a clinical assessment. Original biologic drugs and the corresponding biosimilars were usually in the same homogeneous group, and internal reference pricing was usually employed. The reimbursement rate of biosimilars in the majority of the countries was the same and amounted to 100%. Generally, the higher shares of expenditures were shown for the reimbursement of original drugs than for biosimilars, except for filgrastim, somatropin, and epoetin (alfa and zeta. The shares of expenditures on the reimbursement of biosimilar products ranged from 8.0% in Estonia in 2014 to 32.4% in Lithuania in 2015, and generally increased in 2015. The share of expenditures on reimbursement of biosimilars in the total pharmaceutical budget

  8. On the impact of emissions from central European cities on tropospheric chemistry and climate

    Science.gov (United States)

    Huszar, P.

    2015-12-01

    For the purpose of qualifying and quantifying the impact of urban emission from Central European cities on the present-day regional air-quality, the regional climate model RegCM4.2 was coupledwith the chemistry transport model CAMx, including two-way interactions. A series of simulations was carried out for the 2001-2010 period either with all urban emissions included (base case) or without considering urban emissions. Further, the sensitivity of ozone production to urban emissions was examined by performing reduction experiments with -20% emission perturbation of NOx and/orNMVOC. The model was validated using surface measurements of key pollutants. Selected air-quality measures were used as metrics describing the cities emission impact on regional air pollution. Due to urban emissions, significant ozone titration over occurs over cities while over rural areas futher from them, ozone production os modeled, mainly in terms of number of exceedances and accumulated exceedances over the threshold of 40 ppbv. Urban NOx, SO2 and PM2.5 emissionsalso significantly contribute to concentrations in the cities themselves (up to 50-70% for NOx and SO2 , and up to 55% for PM2.5), but the contribution is large over rural areas as well (10-20%).Although air pollution over cities is largely determined by the local urban emissions, considerable (often a few tens of %) fraction of the concentration is attributable to other sources from rural areasand minor cities.The radiative impact of the perturbed air chemistry (gases/aerosols) due to urban emissions is dominated mainly by the aerosol direct/indirect effect and is characterized by decrease of temperatures up to -0.08 K at the surface but the decrease concerns the whole PBL. Decreases are modeled for the PBL height as well, while the impact on total precipitation and wind speed is statistically insignifcant. The impact of all (urban and non-urban) emissions is about up to -0.2, so considerable part of the radiative effects of all

  9. Consumer response to the possible use of a vaccine method to control boar taint v. physical piglet castration with anaesthesia: a quantitative study in four European countries.

    Science.gov (United States)

    Vanhonacker, F; Verbeke, W

    2011-05-01

    In most European countries, male piglets being reared for meat are physically castrated without anaesthesia in order to avoid boar taint and to safeguard sensory meat quality. This method is increasingly criticised for its violation of piglet welfare. Alternative methods are being researched and castration with anaesthesia or analgesia and vaccination (immunisation) against gonadotropin-releasing hormone (using Improvac®, Pfizer GmbH) have been proposed as possible solutions. In addition to efficacy, the successful introduction and adoption of the vaccine method by stakeholders in pig supply chains are expected to depend on a favourable reception by consumers. This large-scale quantitative cross-country study (n = 4031) involving representative samples of consumers in France, Germany, the Netherlands and Belgium does not support the reserved attitude of stakeholders who fear potential low market acceptance. The vaccine method was actually preferred by the majority of consumers surveyed (69.6% of the participants) and it was perceived as equally effective in terms of avoiding boar taint; 43.8% of the consumers reported an intention to seek out pork from pigs where the vaccine had been used to control boar taint, whereas 33.7% reported an intention to avoid pork from pigs physically castrated with anaesthesia. Consumers' favourable dispositions to the vaccine method were independent of dominant ethical, health or price orientations when purchasing pork.

  10. The European Central Bank and the US Federal Reserve as Lender of Last Resort

    National Research Council Canada - National Science Library

    Hansjörg Herr

    2014-01-01

    .... However, the chance to fundamentally restructure the financial system was not used. The ECB was confronted with sovereign debt crises and an incomplete integration of the European Monetary Union (EMU...

  11. A case of low success of blind vaccination campaigns against myxomatosis and rabbit haemorrhagic disease on survival of adult European wild rabbits.

    Science.gov (United States)

    Rouco, Carlos; Moreno, Sacramento; Santoro, Simone

    2016-10-01

    Vaccination campaigns against myxomatosis and rabbit haemorrhagic disease (RHD) are commonly used in translocation programs conducted for the purpose of recovering wild European rabbit populations in Iberian Mediterranean ecosystems. In most cases rabbits are vaccinated 'blind' (i.e. without assessing their prior immunological status) for economic and logistic reasons. However, there is conflicting evidence on the effectiveness of such an approach. We tested whether blind vaccination against myxomatosis and rabbit haemorrhagic disease improved rabbit survival in a rabbit translocation program where wild rabbits were kept in semi-natural conditions in three enclosures. We conducted nine capture sessions over two years (2008-2010) and used the information collected to compare the survival of vaccinated (n=511) versus unvaccinated (n=161) adult wild rabbits using capture-mark-recapture analysis. Average monthly survival was no different for vaccinated versus unvaccinated individuals, both in the period between release and first capture (short-term) and after the first capture onward (long-term). Rabbit survival was lower in the short term than in the long term regardless of whether rabbits were vaccinated or not. Lower survival in the short-term could be due to the stress induced by the translocation process itself (e.g. handling stress). However, we did not find any overall effect of vaccination on survival which could be explained by two non-exclusive reasons. First, interference of the vaccine with the natural antibodies in the donor population. Due to donor populations have high density of rabbits with, likely, high prevalence of antibodies as a result of previous natural exposure to these diseases. Second, the lack of severe outbreaks during the study period. Based on our findings we argue that blind vaccination of adult rabbits in translocation programs may be often mostly ineffective and unnecessarily costly. In particular, since outbreaks are hard to predict

  12. Multilingual Maps of the Terrestrial Planets and their Moons: the East and Central European Edition

    Science.gov (United States)

    Hargitai, H.; Berczi, Sz.

    A series of Multilingual planetary maps has been published by the Cosmic Materials Space Research Group of the Eötvös Loránd University (Budapest, Hungary) with consultations by Russian and German colleagues. The maps are a result of a cooperation of MIIGAiK (which offered the base maps), ELTE, the Copernicus Observatory and Planetarium in Brno, the Zagreb Astronomical Observatory, the Jagellonian University Observatory, the Tectonics and Geological Cartography Section of the Faculty of Geology at Warsaw University and the University of Architecture, Civil Engeneering and Geodesy in Sofia. The series has been initiated by the International Cartographic Association (ICA), Commission on Planetary Cartography (Shingareva et al. 2006). The now complete series has been published from 2001 to 2006: Mars (2001), Venus (2003), Moon (2003), Mercury (2004) and Phobos and Deimos (2006). (Hargitai et al 2001-2006) These maps are more than outreach posters but less than maps for scientific purposes. These give a good overview of the topography and geology of the planets in a global to regional scale. They contain multilingual information concerning planetary science results and specific characteristics of the planetary body relief, placed on the lower margins of the front sides of the maps and the whole back side (geography, geology, stratigraphy, history of discovery and full index of names). These texts appear in Czech, Bulgarian, Hungarian, Croatian, Polish and English. In some cases it was the first time that a particular term (and its definition) was translated into one of these Central European languages. After compiling the first four maps it can be concluded that such work can effectively draw the attention of earth scientists to the specific features - and the mere existence - of other planetary bodies by simply discussing the translation of their terminology. Apart from circulating the maps in classrooms, this might be the most important scientific result of this

  13. The role of fire in the Central European lowlands during the Holocene: what we know so far

    Science.gov (United States)

    Dietze, Elisabeth; Theuerkauf, Martin; Słowiński, Michał; Brauer, Achim

    2017-04-01

    The modern landscape of the Central European lowlands results from the complex interaction between its geological and geomorphological configuration that developed during and after the last glaciation as well as its Holocene vegetation history, climate evolution and human activity. Although also fire is known to play a fundamental role in many ecosystems of the world and to be one of the major tools for anthropogenic land cover change, Holocene paleofire history has only marginally been studied in the area of the Central European lowlands so far. Here, we will present the first attempt to establish a Holocene fire synthesis for the Central European lowlands. In a first step, we aim to reconstruct the regional Holocene fire history by comparing available sedimentary charcoal records from lakes and peatlands of northern Germany, northern Poland and the Baltic countries. We will present the current knowledge on the role of fire during different time windows such as the Neolithic period, the Medieval time and the onset of industrialization. In addition, we will discuss the interaction between fire, human activity, vegetation and climate change during the last 250 years in more detail using high-resolution records of sedimentary charcoal and the fire biomarkers levoglucosan, mannosan and galactosan from the annually laminated lake sediments of Lake Czechowskie, northern Poland. Teams: CEL synthesis - A. Feurdean, M. Obremska, M. Lamentowicz, K. Marcisz, W. Dörfler, I. Feeser, N. Dräger, F. Ott, T. Giesecke, S. Jahns, L. Shumilovskikh, S. Veski, M. Wieckowska-Lüth, J. Wiethold; Czechowskie fire biomarkers - E.C. Hopmans, L.T. Schreuder, M. Obremska, A. Pieńczewska, O. Blarquez, F. Ott, D. Brykala, S. Schouten

  14. Vaccination against human papillomavirus among 865 female students from the health professions in central Greece: a questionnaire- based cross-sectional study

    Directory of Open Access Journals (Sweden)

    Papagiannis D

    2013-11-01

    Full Text Available Dimitrios Papagiannis,1 George Rachiotis,1 Emmanouil K Symvoulakis,2 Alexandros Daponte,3 Ioanna N Grivea,4 George A Syrogiannopoulos,4 Christos Hadjichristodoulou11Department of Hygiene and Epidemiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Thessalia, 2Private Family Practice Unit, Heraklion, Crete, 3Department of Obstetrics and Gynaecology, University of Thessalia Medical School, Thessalia, 4Department of Paediatrics, University of Thessaly, School of Medicine, General University Hospital of Larissa, Thessalia, GreeceBackground: There are still sparse data on vaccination coverage against human papillomavirus (HPV among students in the health professions. The aim of this study was to investigate HPV vaccination coverage in female students from the health professions in Greece.Methods: A self-administered, anonymous questionnaire was distributed to second-year and third-year female students pursuing degrees in medicine, nursing, and paramedical health disciplines in central Greece.Results: Overall vaccination coverage was 44.3%. The major reason for lack of vaccination was fear about safety of the vaccine. Participants who had received information about safety of the vaccine from the mass media and paramedical students had lower vaccination coverage in comparison with students who had received information about vaccine safety from alternative sources.Conclusion: Further quantitative and qualitative research is needed to design educational activities targeting female students in the health professions in order to create a positive domino effect and improve HPV vaccination coverage levels in Greece.Keywords: human papillomavirus, vaccination, coverage, students, health professions, mass media, Greece

  15. Culture Matters: French-German Conflicts on European Central Bank Independence and Crisis Resolution

    NARCIS (Netherlands)

    Jong, E. de; Esch, F.A.W.J. van

    2014-01-01

    The European sovereign debt crisis has brought to the fore a fault line between German and French politicians and board members of the ECB. In this paper we argue that these differences are rooted in cultural differences between Germany and France. This position is based on previous research on the

  16. The Interpretation of Circular Priorities to Central European Business Environment with Focus on Hungary

    Directory of Open Access Journals (Sweden)

    Fogarassy Csaba

    2017-05-01

    Full Text Available In recent years, there was an increase in economic concepts which defined various concepts for the European Union to leave the economic depression behind. The idea of circular economy boomed into the sight of European Union policy makers in the beginning of 2015. The notion introduced a holistic system planning approach for EU development initiatives. This paper introduces the essential background for the interpretation of circular economy and presents the main priorities throughout its implementation. The size of the European Community leaves many opportunities for the reconsideration of circular processes. The study focuses on circular applications in Hungary which substantially differ from the Western-European practice. The different wage and development levels of the member states in some cases might appear as a possibility to extend product life cycles which otherwise would end sooner. The analysis aims to find the reasons for the variant operations and examines how the extended spatial perspective from national levels to the EU level influences the transition to circular economy.

  17. Policy issues surrounding processes of centralization and decentralization in European education systems

    NARCIS (Netherlands)

    van Amelsvoort, H.W.C.H.; Scheerens, Jaap

    1997-01-01

    Four levels of authority within the educational decision‐making structure in seven European countries and states for primary and lower secondary education are analyzed. Next, the results of an investigation on loci, domains and modes of decision making are presented, indicating a slightly higher

  18. Different trends in euthanasia acceptance across Europe. A study of 13 western and 10 central and eastern European countries, 1981-2008.

    Science.gov (United States)

    Cohen, Joachim; Van Landeghem, Paul; Carpentier, Nico; Deliens, Luc

    2013-06-01

    We examined how acceptance of euthanasia among the general public has changed between 1981 and 2008 in western and central and eastern European (CEE) countries using data of the European Values Surveys. Data were collected in 1981, 1990, 1999 and 2008 for 13 western European countries and in 1990, 1999 and 2008 for 10 CEE countries. Euthanasia acceptance increased each decade up until 2008 in 11 of 13 western European countries; in CEE countries, it decreased or did not increase between 1999-2008 in 8 of 10 countries. A number of explanations for and implications of this apparent east-west polarization are suggested.

  19. Central-European Jesuit Scientists in China, and Their Impact on Chinese Science

    Directory of Open Access Journals (Sweden)

    Stanislav Jože JUŽNIČ

    2015-12-01

    The Jesuits acted as intermediate in the exchange of know-how between Europe and China. In modern Chinese eyes they were also somewhat viewed as spies, who helped European military and economic victories in the mid-19th century. Modern China is now as strong as it was in the times of Old Jesuit Society, therefore the Europocentric history of science must be rewritten from the standpoint of today’s winning Chinese economy. What kind of science will Western Civilization import from the future Chinese literati? The Jesuits’ transfer of European Sciences to the Far-Easterners caused the reverse impact from seemingly less developed centers of Far East that was felt in Jesuits’ times, but much more is to follow in the near future. We could expect the fundamental future Chinese achievements in cosmology, especially in Einstein’s general theory of relativity.

  20. A decade of Central and Eastern European Proteomic Conference (CEEPC): Credibility, cohesion and vision for the next decade.

    Science.gov (United States)

    Gadher, Suresh Jivan; Kovarova, Hana

    2017-02-05

    The Central and Eastern European Proteomic Conference (CEEPC), has reached a special milestone as it celebrates its 10th anniversary. Today, an expansive network of proteomics in Central and Eastern Europe stands established to facilitate scientific interactions and collaborations in and around Central and Eastern Europe, as well as with international research institutions worldwide. Currently, when many conferences are struggling to attract participants, CEEPC is thriving in its status and stature as well as expanding by attracting newer member countries. CEEPC's success is driven by mutual respect between scientists sharing interest in proteomics and its applications in multidisciplinary research areas related to biological systems. This effort when interwoven with exciting ambience steeped with culture, and tradition is also a reason why participants enjoy it. CEEPC's careful balance between excellence and cohesion holds the key to its success. It is evident that CEEPC is ready for the next decade of excitement and expectations of multifaceted proteomics in Central and Eastern Europe. Additionally, in the era of emerging personalized medicine where treatment selection for each patient is becoming individualized, CEEPC and proteomics is expected to play a significant role moving forward for the benefit of mankind. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Central vasopressin infusion prevents hibernation in the European hamster (Cricetus cricetus).

    Science.gov (United States)

    Hermes, M L; Buijs, R M; Masson-Pévet, M; van der Woude, T P; Pévet, P; Brenklé, R; Kirsch, R

    1989-01-01

    The amount of immunocytochemically detectable vasopressin in the brain of the European hamster (Cricetus cricetus) shows a seasonal variation; i.e., dense vasopressin immunoreactivity is present in the lateral septum during summer but is absent in autumn and winter [Buijs, R. M., Pévet, P., Masson-Pévet, M., Pool, C. W., De Vries, G. J., Canguilhem, B. & Vivien-Roels, B. (1986) Brain Res. 371, 193-196]. In the winter period the European hamster hibernates. Since vasopressin in the lateral septum is known to be involved in the control of body temperature, we investigated whether infusion of vasopressin in the lateral septum during autumn-winter could influence hypothermic patterns normally seen in hibernating animals. Hamsters whose lateral septum was infused with vasopressin showed almost no periods of hypothermia, whereas hamsters treated with control infusions displayed a normal hibernation pattern. The results indicate that persistence of vasopressin release in the lateral septum of the European hamster during winter can prevent hibernation. Images PMID:2762331

  2. Molecular and comparative morphological analysis of central European parasitic flatworms of the superfamily Brachylaimoidea Allison, 1943 (Trematoda: Plagiorchiida).

    Science.gov (United States)

    Heneberg, Petr; Sitko, Jiljí; Bizos, Jiří

    2016-04-01

    The Brachylaimoidea are digenean parasites of vertebrates, including humans, domestic animals, poultry and wild game. Numerous Brachylaimoidea, particularly adults of Brachylaima and Leucochloridium, are difficult to identify to species. We provide and analyse sequences of two nuclear (18S rDNA, ITS2) and two mitochondrial (CO1, ND1) DNA loci of central European species of the Brachylaimoidea, namely Leucochloridium holostomum, Leucochloridium paradoxum, Leucochloridium perturbatum, Leucochloridium subtilis, Leucochloridium vogtianum, Urotocus rossitensis, Urogonimus macrostomus, Michajlovia migrata, Leucochloridiomorpha lutea, Brachylaima arcuatus, Brachylaima fuscata and Brachylaima mesostoma. We identified three clades in the genus Leucochloridium, which do not correspond to the previously suggested subgenera Neoleucochloridium, Papilloleucochloridium and Leucochloridium. We reject classification of Urotocus and Urogonimus in Leucochloridiinae, and, instead, re-establish the subfamilies Urotocinae and Urogoniminae. We synonymize the genus Renylaima with the genus Brachylaima. We reject M. migrata as a member of Leucochloridiinae sensu stricto or Brachylaimidae suggested by some previous authors. We found that the previously sequenced Glaphyrostomum sp. does not cluster with any hitherto sequenced Brachylaimidae. We also provide comparative measurements of the examined central European Brachylaimoidea, address the the specificity of their localization in the host and discuss their host-specific prevalence and intensity of infections based on the extensive dataset of birds examined in 1962-2015.

  3. The influence of dietary β-glucans on the adaptive and innate immune responses of European sea bass (Dicentrarchus labrax vaccinated against vibriosis

    Directory of Open Access Journals (Sweden)

    Pier Paolo Gatta

    2010-01-01

    Full Text Available The effects of feeding 1,3/1,6 β-glucans on the innate and the adaptive immune responses of European sea bass (Dicentrarchus labrax was investigated. Two experiments were carried out during the study. In the first, a number of non-specific immune parameters were examined at 4, 7, 10, 14, 21 and 25 days of feeding fish with a semipurified diet containing Macrogard ©, a commercially available form of 1,3/1,6 β-glucans. The respiratory burst activity of head kidney macrophages isolated from the different groups of fish fed the immunostimulant peaked and subsequently decreased at different times during the experiment. Head kidney macrophages from fish fed 250 ppm β-glucans had a statistically higher level of respiratory burst activity at Day 21 of feeding compared with fish fed no immunostimulant. No statistical differences were observed in lyzozyme activity during this trial. In the second experiment, the effect of feeding 1,3/1,6 β-glucans on the immune response of fish to an alginate-encapsulated Vibrio vaccine administered orally was examined. Respiratory burst of head kidney macrophages and serum lysozyme activity decreased in all fish over the course of the trial, while serum lysozyme activity was considerably lower than values obtained in the first experiment. Fish vaccinated orally had significant increases in antibody response by Week 2 post-vaccination, but β-glucans did not appear to affect these levels. Vaccination may have resulted in activating the immune system as a whole, thus masking any difference in immunostimulation by the β-glucans. It may be that the optimal doses and timing of β-glucans administration is different when the immunostimulant is administered alone or in combination with the vaccine. In conclusion, European sea bass can be immunomodulated with oral administration of β-glucan. Optimal doses and administration times have been established when β-glucans are fed alone, although further studies are needed to

  4. Integrative taxonomy of central European parasitic flatworms of the family Prosthogonimidae Lühe, 1909 (Trematoda: Plagiorchiida).

    Science.gov (United States)

    Heneberg, Petr; Sitko, Jiljí; Bizos, Jiří

    2015-10-01

    Species of the family Prosthogonimidae are considered the most pathogenic poultry trematodes worldwide, affecting particularly low intensity farming in rural areas. Adults of Prosthogonimus occur mainly in the bursa of Fabricius, oviduct and cloaca of ducks, geese, fowl and other birds feeding at least occasionally on dragonflies or damselflies (Odonata). We analyzed the central European species of the Prosthogonimidae, namely Prosthogonimus cuneatus, Prosthogonimus ovatus, Prosthogonimus pellucidus and Prosthogonimus rarus. We sequenced three nuclear (ITS2) and mitochondrial (CO1, ND1) DNA loci of four species isolated from Anas clypeata, Anas strepera, Anas platyrhynchos, Aythya ferina, Passer domesticus and Turdus merula. Intra- and inter-specific sequence variability revealed that all four species represent distinct well-defined entities. Our data, combined with previously published studies, suggest the return of the name Prosthogonimus rarus Braun, 1901 for Schistogonimus rarus (Braun, 1901). The genus name Schistogonimus Lühe, 1909 is considered a junior synonym of Prosthogonimus Lühe, 1899. We identified the existence of two clades, one represented by P. cuneatus and P. pellucidus, and another one formed by P. ovatus and P. rarus. We also provide comparative measurements of these four central European prosthogonimids, and address their tissue specificity, host-specific prevalence (based on the extensive bird cohort examined in years 1962-2014), and for some bird hosts we address also differences in the prevalence of Prosthogonimus spp. in natural and near-natural wetlands in comparison with fishponds utilized for intense carp production. We provide an updated key to European Prosthogonimus spp. based on their morphological characters. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. Uniparental Genetic Heritage of Belarusians: Encounter of Rare Middle Eastern Matrilineages with a Central European Mitochondrial DNA Pool

    Science.gov (United States)

    Kushniarevich, Alena; Sivitskaya, Larysa; Danilenko, Nina; Novogrodskii, Tadeush; Tsybovsky, Iosif; Kiseleva, Anna; Kotova, Svetlana; Chaubey, Gyaneshwer; Metspalu, Ene; Sahakyan, Hovhannes; Bahmanimehr, Ardeshir; Reidla, Maere; Rootsi, Siiri; Parik, Jüri; Reisberg, Tuuli; Achilli, Alessandro; Hooshiar Kashani, Baharak; Gandini, Francesca; Olivieri, Anna; Behar, Doron M.; Torroni, Antonio; Davydenko, Oleg; Villems, Richard

    2013-01-01

    Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting the Republic of Belarus. Belarusians together with Ukrainians and Russians represent the East Slavic linguistic group, largest both in numbers and territory, inhabiting East Europe alongside Baltic-, Finno-Permic- and Turkic-speaking people. Till date, only a limited number of low resolution genetic studies have been performed on this population. Therefore, with the phylogeographic analysis of 565 Y-chromosomes and 267 mitochondrial DNAs from six well covered geographic sub-regions of Belarus we strove to complement the existing genetic profile of eastern Europeans. Our results reveal that around 80% of the paternal Belarusian gene pool is composed of R1a, I2a and N1c Y-chromosome haplogroups – a profile which is very similar to the two other eastern European populations – Ukrainians and Russians. The maternal Belarusian gene pool encompasses a full range of West Eurasian haplogroups and agrees well with the genetic structure of central-east European populations. Our data attest that latitudinal gradients characterize the variation of the uniparentally transmitted gene pools of modern Belarusians. In particular, the Y-chromosome reflects movements of people in central-east Europe, starting probably as early as the beginning of the Holocene. Furthermore, the matrilineal legacy of Belarusians retains two rare mitochondrial DNA haplogroups, N1a3 and N3, whose phylogeographies were explored in detail after de novo sequencing of 20 and 13 complete mitogenomes, respectively, from all over Eurasia. Our phylogeographic analyses reveal that two mitochondrial DNA lineages, N3 and N1a3, both of Middle Eastern origin, might mark distinct events of matrilineal gene flow to Europe: during the mid-Holocene period and around the Pleistocene-Holocene transition, respectively. PMID:23785503

  6. Ancient DNA analysis reveals high frequency of European lactase persistence allele (T-13910 in medieval central europe.

    Directory of Open Access Journals (Sweden)

    Annina Krüttli

    Full Text Available Ruminant milk and dairy products are important food resources in many European, African, and Middle Eastern societies. These regions are also associated with derived genetic variants for lactase persistence. In mammals, lactase, the enzyme that hydrolyzes the milk sugar lactose, is normally down-regulated after weaning, but at least five human populations around the world have independently evolved mutations regulating the expression of the lactase-phlorizin-hydrolase gene. These mutations result in a dominant lactase persistence phenotype and continued lactase tolerance in adulthood. A single nucleotide polymorphism (SNP at C/T-13910 is responsible for most lactase persistence in European populations, but when and where the T-13910 polymorphism originated and the evolutionary processes by which it rose to high frequency in Europe have been the subject of strong debate. A history of dairying is presumed to be a prerequisite, but archaeological evidence is lacking. In this study, DNA was extracted from the dentine of 36 individuals excavated at a medieval cemetery in Dalheim, Germany. Eighteen individuals were successfully genotyped for the C/T-13910 SNP by molecular cloning and sequencing, of which 13 (72% exhibited a European lactase persistence genotype: 44% CT, 28% TT. Previous ancient DNA-based studies found that lactase persistence genotypes fall below detection levels in most regions of Neolithic Europe. Our research shows that by AD 1200, lactase persistence frequency had risen to over 70% in this community in western Central Europe. Given that lactase persistence genotype frequency in present-day Germany and Austria is estimated at 71-80%, our results suggest that genetic lactase persistence likely reached modern levels before the historic population declines associated with the Black Death, thus excluding plague-associated evolutionary forces in the rise of lactase persistence in this region. This new evidence sheds light on the dynamic

  7. Petrology and deformation style of lithospheric mantle beneath the Heldburg Dike swarm (Central Germany) subset of Central European Volcanic Province

    Science.gov (United States)

    Kukuła, Anna; Puziewicz, Jacek; Hidas, Károly; Ntaflos, Theodoros; Matusiak-Małek, Magdalena; Milke, Ralf

    2017-04-01

    The Heldburg Dike swarm is a set of Cenozoic alkali basalt dikes occurring in the central part of Germany at the border between Thuringia and Bavaria. We studied xenoliths from Strauf, Feldstein, Bramberg and from the active quarry in Zeilberg. The peridotites from Strauf, Feldstein and Bramberg have the composition of spinel lherzolite (15), spinel harzburgite (9) and dunite (3). They vary in size from 1.5 cm (Strauf) up to 20 cm (Zeilberg). We distinguish groups (A, A- and B) of peridotites based on different forsterite content in olivine. Group A consists of olivine (89.6 - 91.8 Fo), orthopyroxene (Mg# 0.90-0.93, Al 0.05-0.18 a pfu), clinopyroxene (Mg# 0.87-0.95, Al 0.06-0.26 a pfu) and spinel (Cr# 0.13-0.65, Mg# 0.54-0.78). Clinopyroxene rare earth elements (REE) patterns are S-shaped (Feldstein, Bramberg) or U-shaped (Strauf); spoon-shaped patterns occur occasionally. Trace element (TE) patterns show negative Nb, Ta, Zr, Hf, Ti and positive Th, U anomalies. The most magnesian clinopyroxene (xenolith 3140, Feldstein) is strongly aluminous and LREE depletedwith weak anomalies in TE patterns. Group A- is contains olivine (88.9-89.5 Fo), orthopyroxene (Mg# 0.89-0.90, Al 0.10-0.13 a pfu) and clinopyroxene (Mg# 0.90-0.92, Al 0.10-0.17 a pfu). Clinopyroxene is increasingly enriched in REEs from Lu to La. TE patterns are similar to those of group A but with less pronounced anomalies. Group B (3 xenoliths only) consists of olivine Fo 86.7-88.9, orthopyroxene (Mg# 0.88-0.89, Al 0.07-0.19 a pfu), clinopyroxene (Mg# 0.88-0.90, Al 0.10-0.26 a pfu). Clinopyroxene is enriched in LREE, concave upward in Pr. TE patterns are similar to those in group A. One of group B harzburgites contains grains (up to 0.5 mm) of Ca-Mg carbonate located in interstices. The clinopyroxene chemical composition plots away from the melting trend in the MgO-Al2O3 diagram of Upton et al. (2011), suggesting a later addition of the clinopyroxene. The composition of orthopyroxene corresponds to ca. 15

  8. The Honey Bee Pathosphere of Mongolia: European Viruses in Central Asia

    Science.gov (United States)

    Tsevegmid, Khaliunaa; Neumann, Peter; Yañez, Orlando

    2016-01-01

    Parasites and pathogens are apparent key factors for the detrimental health of managed European honey bee subspecies, Apis mellifera. Apicultural trade is arguably the main factor for the almost global distribution of most honey bee diseases, thereby increasing chances for multiple infestations/infections of regions, apiaries, colonies and even individual bees. This imposes difficulties to evaluate the effects of pathogens in isolation, thereby creating demand to survey remote areas. Here, we conducted the first comprehensive survey for 14 honey bee pathogens in Mongolia (N = 3 regions, N = 9 locations, N = 151 colonies), where honey bee colonies depend on humans to overwinter. In Mongolia, honey bees, Apis spp., are not native and colonies of European A. mellifera subspecies have been introduced ~60 years ago. Despite the high detection power and large sample size across Mongolian regions with beekeeping, the mite Acarapis woodi, the bacteria Melissococcus plutonius and Paenibacillus larvae, the microsporidian Nosema apis, Acute bee paralysis virus, Kashmir bee virus, Israeli acute paralysis virus and Lake Sinai virus strain 2 were not detected, suggesting that they are either very rare or absent. The mite Varroa destructor, Nosema ceranae and four viruses (Sacbrood virus, Black queen cell virus, Deformed wing virus (DWV) and Chronic bee paralysis virus) were found with different prevalence. Despite the positive correlation between the prevalence of V. destructor mites and DWV, some areas had only mites, but not DWV, which is most likely due to the exceptional isolation of apiaries (up to 600 km). Phylogenetic analyses of the detected viruses reveal their clustering and European origin, thereby supporting the role of trade for pathogen spread and the isolation of Mongolia from South-Asian countries. In conclusion, this survey reveals the distinctive honey bee pathosphere of Mongolia, which offers opportunities for exciting future research. PMID:26959221

  9. The Honey Bee Pathosphere of Mongolia: European Viruses in Central Asia.

    Directory of Open Access Journals (Sweden)

    Khaliunaa Tsevegmid

    Full Text Available Parasites and pathogens are apparent key factors for the detrimental health of managed European honey bee subspecies, Apis mellifera. Apicultural trade is arguably the main factor for the almost global distribution of most honey bee diseases, thereby increasing chances for multiple infestations/infections of regions, apiaries, colonies and even individual bees. This imposes difficulties to evaluate the effects of pathogens in isolation, thereby creating demand to survey remote areas. Here, we conducted the first comprehensive survey for 14 honey bee pathogens in Mongolia (N = 3 regions, N = 9 locations, N = 151 colonies, where honey bee colonies depend on humans to overwinter. In Mongolia, honey bees, Apis spp., are not native and colonies of European A. mellifera subspecies have been introduced ~60 years ago. Despite the high detection power and large sample size across Mongolian regions with beekeeping, the mite Acarapis woodi, the bacteria Melissococcus plutonius and Paenibacillus larvae, the microsporidian Nosema apis, Acute bee paralysis virus, Kashmir bee virus, Israeli acute paralysis virus and Lake Sinai virus strain 2 were not detected, suggesting that they are either very rare or absent. The mite Varroa destructor, Nosema ceranae and four viruses (Sacbrood virus, Black queen cell virus, Deformed wing virus (DWV and Chronic bee paralysis virus were found with different prevalence. Despite the positive correlation between the prevalence of V. destructor mites and DWV, some areas had only mites, but not DWV, which is most likely due to the exceptional isolation of apiaries (up to 600 km. Phylogenetic analyses of the detected viruses reveal their clustering and European origin, thereby supporting the role of trade for pathogen spread and the isolation of Mongolia from South-Asian countries. In conclusion, this survey reveals the distinctive honey bee pathosphere of Mongolia, which offers opportunities for exciting future research.

  10. Central and East European migrant men who have sex with men in London: a comparison of recruitment methods

    Directory of Open Access Journals (Sweden)

    Gerry Christopher J

    2011-05-01

    Full Text Available Abstract Background Following the expansion of the European Union, there has been a large influx of Central and East European (CEE migrants to the UK. CEE men who have sex with men (MSM represent a small minority within this population that are none-the-less important to capture in sexual health research among the CEE migrant community. This paper examines the feasibility of recruiting CEE MSM for a survey of sexual behaviour in London using respondent driven sampling (RDS, via gay websites and in GUM clinics. Methods We sought CEE MSM to start RDS chain referral among GUM clinic attendees, our personal contacts and at gay events and venues in central London. We recruited CEE MSM (n = 485 via two popular websites for gay men in Britain (March-May 2009 and at two central London GUM clinics (n = 51 (July 2008-March 2009. Results We found seventeen men who knew other CEE MSM in London and agreed to recruit contacts into the study. These men recruited only three men into the study, none of whom recruited any further respondents, and RDS was abandoned after 7 months (July 2008-January 2009. Half of the men that we approached to participate in RDS did not know any other CEE MSM in London. Men who agreed to recruit contacts for RDS were rather more likely to have been in the UK for more than one year (94.1% vs 70.0%, p = 0.052. Men recruited through gay websites and from GUM clinics were similar. Conclusions The Internet was the most successful method for collecting data on sexual risk behaviour among CEE MSM in London. CEE MSM in London were not well networked. RDS may also have failed because they did not fully understand the procedure and/or the financial incentive was not sufficient motivation to take part.

  11. Treatment of hypertension in central and eastern European countries: self-reported practice of primary care physicians.

    Science.gov (United States)

    Tomasik, Tomasz; Windak, Adam; Jozwiak, Jacek; Oleszczyk, Marek; Seifert, Bohumil; Kersnik, Janko; Kryj-Radziszewska, Elzbieta

    2012-08-01

    To describe self-reported hypertension treatment among primary care physicians in central and eastern Europe and to investigate international differences. A cross-sectional survey of primary care physicians with a questionnaire translated into various languages was carried out in nine central and eastern European countries. Three thousand physicians were randomly selected from the national registers. Eight hundred and sixty-seven invited primary care physicians responded. For the patients with hypertension and low cardiovascular risk, 49% of physicians reported a treatment goal of less than 140/90 mmHg (69% in Slovenia, 20% in Latvia, P hypertension and diabetes mellitus, blood pressure (BP) targets of less than 130/80 mmHg and less than 120/80 mmHg were reported by 47 and 48% of physicians, respectively, and significant differences between countries were revealed. Angiotensin-converting enzyme inhibitors were the most common declared drugs used on a daily basis (over 90% of physicians in all countries). Various international differences were observed among the use of diuretics, β-blockers and drugs from other classes. An immediate initiation of pharmacotherapy was declared by 24% of physicians at a SBP level of at least 180 mmHg and 20% at DBP level of at least 110 mmHg. In hypertension treatment, some decisions made by primary care physicians from central and eastern European countries are still done without any supporting evidence from clinical trials. They have declared lower treatment goals and the initiation of pharmacotherapy at lower BP levels than recommended in international guidelines. An innovative approach to continuous medical education should be introduced and the efforts to implement guidelines in everyday practice ought to continue.

  12. Local species richness of Central European hoverflies (Diptera : Syrphidae): a lesson taught by local faunal lists

    Czech Academy of Sciences Publication Activity Database

    Keil, P.; Konvička, Martin

    2005-01-01

    Roč. 11, č. 5 (2005), s. 471-426 ISSN 1366-9516 R&D Projects: GA AV ČR(CZ) KJB6007306 Institutional research plan: CEZ:AV0Z50070508 Keywords : central Europe * diversity determinants * geography Subject RIV: EH - Ecology, Behaviour Impact factor: 3.345, year: 2005

  13. A critical reassessment of cultural taxonomies in the Central European Late Palaeolithic

    DEFF Research Database (Denmark)

    Sauer, Florian Rudolf; Riede, Felix

    2017-01-01

    In the analysis of archaeological relationships and processes, a uniform classification of the dataset is a fundamental requirement. To achieve this, a standardized taxonomic system, as well as consistent and valid criteria for the grouping of sites and assemblages must be used. The Central...

  14. Cigarette Smoking and Indicators of Psychosocial Distress in Southeast Asian and Central-Eastern European Adolescents

    Science.gov (United States)

    Page, Randy M.; Zarco, Emilia Patricia T.; Ihasz, Ferenc; Suwanteerangkul, Jiraporn; Uvacsek, Martina; Mei-Lee, Ching; Miao, Nae-Fang; Simonek, Jaromir; Klarova, Renata; Hantiu, Iacob; Kalabiska, Iren

    2008-01-01

    The purpose of this study was to examine the association of cigarette smoking and 2 indicators of psychosocial distress (hopelessness and loneliness) among adolescents from 2 distinctly different regions of the world: Central-Eastern Europe (Hungary, Ukraine, Slovakia, Czech Republic, Romania, Poland) and Southeast Asia (Thailand, Taiwan, and the…

  15. Laboratories of Reform? The Europeanization and Internationalization of Higher Education in Central and Eastern Europe

    Science.gov (United States)

    Dakowska, Dorota; Harmsen, Robert

    2015-01-01

    This introductory article deals with higher education (HE) transformations in Central and Eastern Europe in the context of democratization and globalization. The authors first briefly survey the wider canvas of reform since 1989, particularly probing the extent to which the countries of the region may be treated as a distinctive or a cohesive…

  16. Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.

    Science.gov (United States)

    Shaw, C A; Tomljenovic, L

    2013-07-01

    We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.

  17. Toward a more professional and practical medical education: a novel Central European approach.

    Science.gov (United States)

    Drexel, Heinz; Vonbank, Alexander; Fraunberger, Peter; Riesen, Walter F; Saely, Christoph H

    2015-01-01

    We here present an innovative curriculum for a complete medical education that conforms to the current European Bologna system of academic training. The curriculum aims at raising doctors who are excellently prepared for clinical work over as short a time as 5 years; it provides a comprehensive, yet shorter than usual, education that strongly pronounces the importance of increasing the students' practical clinical competences and rigorously excludes superfluous contents. The curriculum encompasses 52 modules, 32 at the bachelor's and 20 at the master's level. Already at the level of the bachelor degree, full employability is given; the students finish the master's course as medical doctors optimally prepared to manage patients at the level of postgraduate medical education. The structure of the curriculum is modular; each modular component is essential for medical education and contains an average of five European Credit Transfer System credits, amounting to 150 hours of education. Depending on the subspecialty, the courses include lectures, seminars, practical laboratory training, and clinical training at varying quantities. In addition to attendance times, sufficient time slots are prepared for self-study in lectures, seminars, and practical work. With our curriculum, we provide an easily applicable backbone for a modern course of medicine that can be installed also at smaller academic institutions.

  18. Central and Eastern Europeans Migrants’ Subjective Quality of Life. A Comparative Study

    Directory of Open Access Journals (Sweden)

    Sergiu BĂLŢĂTESCU

    2007-11-01

    Full Text Available There is no general agreement among scholars on the consequences oflabor migration on the sending countries. Some argue that the migration would increase the quality of life of the families or communities involved, giving support for democracy and market reforms in these countries, while others share the view that the brain drain and fiscal losses would have long term effects on the sending countries’ development. This paper takes another approach, focusing on the migrant persons’ subjective quality of life.Using data issued in the first two rounds of the European Social Survey (2002/2003, 2004/2005, the Eastern European immigrants’ satisfaction with their lives as a whole and with the social and political environment is measured. They report lower satisfaction with life as a whole, but higher satisfaction with the societal conditions than the natives and other kind of immigrants. Explanation lies in the different sources of these evaluations:when evaluating their overall satisfaction, the immigrants rely on their experiences in their receiving countries, while when evaluating the societal conditions they compare these to those from the sending countries. The fact that they show higher levels of satisfaction with the societal conditions than the other immigrants also supports this hypothesis, because the former are more recent and less accommodated to the receiving society than the latter.

  19. Coming and going in Slovakia: international labour mobility in the Central European 'buffer zone'

    OpenAIRE

    Allan M Williams; Vladimír Baláz; Daniel Kollár

    2001-01-01

    The collision between economic systems after 1989 led to significant new forms of mobility. East Central Europe became a legally and institutional ly constructed 'buffer zone' between Western Europe and the CIS, Commonwealth of Independent States -- the former USSR. The opportunities for and costs of migration in the buffer zone were shaped by the 'double territorial shock' of the transition: reinterationalisation and the withdrawal of massive state intervention in support of regional converg...

  20. Measurement Levels of the Spatial Integration – Suggestions for a Central-European Factor Group

    Directory of Open Access Journals (Sweden)

    Andrea Uszkai

    2015-10-01

    Full Text Available The objective of the study is to point out, what kind of measurement methodologies and factor groups are used to determinate the depth of the spatial integration in the national and international scientific literature. Integration means in this sense the interconnection of several (spatial units (Kulcsár-Rostás, 1989; Kovács, 2001; Kiss, 2005. One of the most widely interpreted types of the integration is the economic integration, which can be applied to enterprises and spatial units as well. This study focuses on the last one and examines it at three territorial levels, distinguishing global, supranational (among national states and subnational levels. The possible measurement methods are significantly determined by the spatial levels. The paper makes some suggestions for the possible measurement method in Cenrtral-European context.

  1. The potential of military training areas for bird conservation in a central European landscape

    Science.gov (United States)

    Bušek, Ondřej; Reif, Jiří

    2017-10-01

    European biodiversity has suffered from serious declines during the past few decades, with alterations of land use practices resulting in a loss of fine-scale habitat heterogeneity being a dominant driver. This heterogeneity was maintained by extensive landscape management, which has gradually been replaced by either intensive exploitation or land abandonment. It has been suggested that military training can generate habitat heterogeneity that may support the existence of species of conservation concern, but studies rigorously testing the real importance of military training areas for biodiversity are lacking. Here we address this issue by analyses of two datasets. First, we compared land cover classes between all large military training areas (MTAs) and surrounding control areas (CAs) of the same size in the Czech Republic using multivariate redundancy analysis. We found that the difference in land cover between MTAs and CAs was significant and represented the strongest gradient in land cover classes: from various farmland and artificial habitats typical for CAs to forest and scrubland-grassland mosaic typical for MTAs. Second, we selected one of these areas and compared bird species richness between the MTA and the nearby CA using generalized linear mixed effects models. We found that the number of species of conservation concern was significantly higher in the MTA than in the CA. With respect to habitats, bird species richness was significantly higher in the MTA than in the CA for open habitats, but not for forest habitats. Our results are thus consistent with the view that military training creates areas that are different from the surrounding landscape in terms of land cover, and that this difference translates to a suitability for species of conservation concern. It is remarkable that the positive influence of military training is confined to open habitats, which are subject to the most intensive military activities and also suffer the highest degree of

  2. The impact of the crisis on the energy demand and energy intensity in Central and Eastern European countries

    Directory of Open Access Journals (Sweden)

    Attila HUGYECZ

    2011-12-01

    Full Text Available The purpose of our paper is to analyze the impact of the recent crisis on the oil and electricity demand and the energy intensity of different Central and Eastern European countries, namely the Czech Republic, Hungary, Poland and Slovakia. Furthermore, we would like to reveal whether there is a lag in the adjustment of energy consumption. In analyzing energy intensity, we use motor gasoline, diesel oil and electricity consumption data and ignore coal and natural gas data. By so doing, we avoid failures arising from changing coal/gas consumption due to changing weather conditions. Our results show that the crisis did impact energy consumption and reveal that the improvement of energy intensity halted in 2009, implying that the economic players did not immediately adjust their energy consumption according to their economic activity. The gasoline and diesel intensity, however, deteriorated (increased only in the Czech Republic and in Hungary. In Slovakia and Poland there were no significant changes.

  3. The Relationship between Youth Unemployment and Economic Growth in Central and Eastern European Countries: An Empirical Analysis

    Directory of Open Access Journals (Sweden)

    Leman ERDAL

    2015-06-01

    Full Text Available The study has analyzed the relationship between youth unemployment and economic growth, in the context of Okun law, by using new generation panel data analysis and cointegration tests. In this study, 18 Central and Eastern European country have been selected as subject matter whose youth unemployment rate is above the EU-28 average (25 % for the period 2006-2012. The results show that, if youth unemployment is quite severe; even an exclusive economic growth will not be enough to reduce the youth unemployment rate in the country. It is recommended that the global and country-specific policies which are effective, result-driven on youth (Un employment and labour market issues, should be developed. This study is expected to make a significant contribution to the literature on unemployment and social conflict.

  4. Comparative analysis of the macronutrient content of Central European ants (Formicidae): implications for ant-eating predators.

    Science.gov (United States)

    Pekár, S; Mayntz, D

    2014-03-01

    Prey nutrient quality determines predator performance. Polyphagous predators can address nutritional challenges by targeting prey with specific nutrient composition, but prey-specialised predators (e.g., ant-eaters), must obtain all nutrients from limited array of prey. Analysis of published data on prey specificity of European ant-eating spiders showed that some feed only on one ant genus, while others feed on several genera. Spiders feeding on several ant genera can possibly balance nutrient intake by selecting different ant prey. But monophagous species must extract all prey from a single prey species and can only vary nutrient intake by feeding on specific body parts. Most ant-eating spider species are catching Formica, Lasius and Messor ants, suggesting that these are most profitable ant species. We evaluated the nutritional content of a variety of 16 Central European ant species belonging to 11 genera and four subfamilies. We found that the nutritional composition, namely the amount of carbon, nitrogen and lipids, of European ants is heterogeneous. The largest variation in the amount of carbon and lipids was among ant subfamilies and species, while the largest variation in nitrogen was among ant genera. The largest amount of carbon and nitrogen was typical for Myrmicinae and the largest amount of lipids were typical for Formicinae. Within ants, the relative amounts of lipids were significantly higher in the gaster while the contents of carbon and nitrogen were highest in foreparts. Ant species did not cluster in the ordination space according to their taxonomic relationship or trophic strategy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Labour Market Trends and Problems in the EU’s Central and Eastern European Member States: Is Flexicurity the Answer?

    Directory of Open Access Journals (Sweden)

    Lothar Funk

    2009-12-01

    Full Text Available Throughout the 1990s, international organisations, such as the International Monetary Fund mainly based their policy proposals for transition economies and the high unemployment, low growth countries in Western Europe, on economic “orthodoxy”. This approach predominantly followed neoclassical economics in which market liberal solutions predominate. These suggestions were controversial; the early results of these policies appeared to be disappointing. Policymakers sought alternative reform proposals and the idea of “flexicurity” has gradually emerged to the political buzzword. Flexicurity combines flexibility with security and suggests that rather generous unemployment benefits and spending on active labour market policies can be aligned with a flexible, employment-friendly labour market. Originating in Denmark, the European Commission and the International Labour Organisation have promoted flexicurity more or less independent of specific single country cases, and based their approach on more abstract, generalised relationships between flexibility and security. These bodies argue for an alternative policy to pure orthodox deregulation and liberalisation for the member states of the European Union (EU and the former transition economies that joined the EU since 2004. After a review of common labour market-related characteristics and problems of the EU’s central and eastern European members, the article summarises and critically evaluates the main elements of flexicurity suggestions. It further compares them to the relevant policy proposals based primarily on more orthodox economic analysis. The analysis shows that several preconditions for a successful flexicurity strategy are still lacking across the new member states. Moreover, the article demonstrates that current proposals by the critics of a single-minded flexicurity approach by no means always disregard potentially positive effects of improving the supposed trade-offs between

  6. Energy supply structures and strategies for the reduction of emissions in selected Central and Eastern European countries

    Energy Technology Data Exchange (ETDEWEB)

    Jattke, A.; Haasis, H.-D.; Oder, C.; Russ, P.; Rentz, O. (University of Karlsruhe, Karlsruhe (Germany). Institute for Industrial Production)

    1993-01-01

    This article sets out to analyse strategies for the reduction of SO[sub 2] and NO[sub x] emissions applied by a selection of Central and Eastern European countries, together with the impact of these strategies upon national energy supply structure. Hungary, Lithuania and the European sector of Russia are used as representative examples of the wide variety of energy industry structures and future developments in Eastern Europe. Current energy supply, transformation and consumer demand conditions in the various economic sectors (industry, transport, the domestic sector, etc.) have been used as a basis for the establishment of the national cost of emission reduction strategies, together with preferred national structure for emission reduction measures. Calculated cost functions are based upon a technical and economic assessment of available energy transformation and emission reduction technologies. The potential of various options for emission reduction, such as the substitution of fuels or technologies, secondary emission reduction techniques and energy conservation measures have also been quantified. This process has been used as a means of identifying and assessing the interdependence of strategies for the reduction of various atmospheric pollutants. The EFOM-ENV Energy/Emission Model has been used as a methodological tool. 15 refs., 13 figs., 1 tab.

  7. Molecular epidemiology of rotavirus gastroenteritis in Central Kenya before vaccine introduction, 2009-2014.

    Science.gov (United States)

    Wandera, Ernest A; Mohammad, Shah; Komoto, Satoshi; Maeno, Yoshimasa; Nyangao, James; Ide, Tomihiko; Kathiiko, Cyrus; Odoyo, Erick; Tsuji, Takao; Taniguchi, Koki; Ichinose, Yoshio

    2017-05-01

    Between July 2009 and June 2014, a total of 1,546 fecal specimens were collected from children rotavirus (RVA) using ELISA, and RVA-positive specimens were subjected to semi-nested RT-PCR to determine the G and P genotypes. RVA was detected in 429/1,546 (27.5%) fecal specimens. RVA infections occurred in all age groups G1P[8] (28%) was the most predominant genotype, followed by G9P[8] (12%), G8P[4] (7%), G1P[4] (5%), G9P[4] (4%), and G12P[6] (3%). In the yearly change of G and P genotypes, a major shift from G9P[8] to G1P[8] was found in 2012. Phylogenetic analysis of the nucleotide sequences of the VP7 and VP4 genes of seven strains with unusual G8 or P[6] showed that the VP7 nucleotide sequences of G8 were clustered in lineage 6 in which African strains are included, and that there are at least two distinct VP4 nucleotide sequences of P[6] strains. These results represent basic data on RVA strains circulating in this region before vaccine introduction. J. Med. Virol. 89:809-817, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  8. Ecological restoration of Central European mining sites: a summary of a multi-site analysis

    Energy Technology Data Exchange (ETDEWEB)

    Prach, K.; Rehounkova, K.; Rehounek, J.; Konvalinkova, P. [University of South Bohemia, Ceske Budejovice (Czech Republic)

    2011-07-01

    Sites disturbed by mining were surveyed in the Czech Republic, central Europe. The sites included spoil heaps from coal mining, sand and gravel pits, extracted peatlands and stone quarries. The following main conclusions emerged: I) potential for spontaneous succession to be used in restoration projects is between 95 and 100% of the total area disturbed; ii) mining sites, if mining is properly designed and then the sites are left to spontaneous succession, often act as refugia for endangered and retreating organisms, and may contribute substantially to local biodiversity.

  9. The extraordinary windstorm of 7 December 1868 in the Czech Lands and its central European context

    Czech Academy of Sciences Publication Activity Database

    Brázdil, Rudolf; Szabó, Péter; Stucki, P.; Dobrovolný, Petr; Řezníčková, Ladislava; Kotyza, O.; Valášek, H.; Melo, M.; Suchánková, Silvie; Dolák, Lukáš; Chromá, Kateřina

    2017-01-01

    Roč. 37, S1 (2017), s. 14-29 ISSN 0899-8418 R&D Projects: GA MŠk(CZ) LO1415; GA ČR(CZ) GA13-19831S; GA ČR(CZ) GA15-11805S Institutional support: RVO:67179843 ; RVO:67985939 Keywords : windstorm of 7 December 1868 * documentary data * Twentieth Century Reanalysis * meteorological situation * damage * forestry * Czech Lands * Central Europe Subject RIV: DG - Athmosphere Sciences, Meteorology; EH - Ecology, Behaviour (BU-J) Impact factor: 3.760, year: 2016

  10. Succession of N cycling processes in biological soil crusts on a Central European inland dune.

    Science.gov (United States)

    Brankatschk, Robert; Fischer, Thomas; Veste, Maik; Zeyer, Josef

    2013-01-01

    Biological soil crusts (BSCs) are microbial assemblages that occur worldwide and facilitate ecosystem development by nitrogen (N) and carbon accumulation. N turnover within BSC ecosystems has been intensively studied in the past; however, shifts in the N cycle during BSC development have not been previously investigated. Our aim was to characterise N cycle development first by the abundance of the corresponding functional genes (in brackets) and second by potential enzyme activities; we focussed on the four processes: N fixation (nifH), mineralisation as proteolysis and chitinolysis (chiA), nitrification (amoA) and denitrification (nosZ). We sampled from four phases of BSC development and from a reference located in the rooting zone of Corynephorus canescens, on an inland dune in Germany. BSC development was associated with increasing amounts of chlorophyll, organic carbon and N. Potential activities increased and were highest in developed BSCs. Similarly, the abundance of functional genes increased. We propose and discuss three stages of N process succession. First, the heterotrophic stage (mobile sand without BSCs) is dominated by mineralisation activity. Second, during the transition stage (initial BSCs), N accumulates, and potential nitrification and denitrification activity increases. Third, the developed stage (established BSCs and reference) is characterised by the dominance of nitrification. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  11. European Union and EDCTP strategy in the global context: recommendations for preventive HIV/AIDS vaccines research

    NARCIS (Netherlands)

    Lehner, Thomas; Hoelscher, Michael; Clerici, Mario; Gotch, Frances; Pedneault, Louise; Tartaglia, Jim; Gray, Clive; Mestecky, Jiri; Sattentau, Quentin; van de Wijgert, Janneke; Toure, Coumba; Osmanov, Saladin; Schmidt, Reinold E.; Debre, Patrice; Romaris, Manuel; Hoeveler, Arnd; Di Fabio, Simonetta

    2005-01-01

    The European Commission (EC) has strong commitments and recognises the need to continue to ensure that HIV/AIDS research efforts receive global attention. The EC is facing this challenge in a global context and has made substantial investments together with European Developing Countries Clinical

  12. Rewriting the Central European Early Bronze Age Chronology: Evidence from Large-Scale Radiocarbon Dating.

    Science.gov (United States)

    Stockhammer, Philipp W; Massy, Ken; Knipper, Corina; Friedrich, Ronny; Kromer, Bernd; Lindauer, Susanne; Radosavljević, Jelena; Wittenborn, Fabian; Krause, Johannes

    2015-01-01

    The transition from the Neolithic to the Early Bronze Age in Central Europe has often been considered as a supra-regional uniform process, which led to the growing mastery of the new bronze technology. Since the 1920s, archaeologists have divided the Early Bronze Age into two chronological phases (Bronze A1 and A2), which were also seen as stages of technical progress. On the basis of the early radiocarbon dates from the cemetery of Singen, southern Germany, the beginning of the Early Bronze Age in Central Europe was originally dated around 2300/2200 BC and the transition to more complex casting techniques (i.e., Bronze A2) around 2000 BC. On the basis of 140 newly radiocarbon dated human remains from Final Neolithic, Early and Middle Bronze Age cemeteries south of Augsburg (Bavaria) and a re-dating of ten graves from the cemetery of Singen, we propose a significantly different dating range, which forces us to re-think the traditional relative and absolute chronologies as well as the narrative of technical development. We are now able to date the beginning of the Early Bronze Age to around 2150 BC and its end to around 1700 BC. Moreover, there is no transition between Bronze (Bz) A1 and Bronze (Bz) A2, but a complete overlap between the type objects of the two phases from 1900-1700 BC. We thus present a revised chronology of the assumed diagnostic type objects of the Early Bronze Age and recommend a radiocarbon-based view on the development of the material culture. Finally, we propose that the traditional phases Bz A1 and Bz A2 do not represent a chronological sequence, but regionally different social phenomena connected to the willingness of local actors to appropriate the new bronze technology.

  13. Rewriting the Central European Early Bronze Age Chronology: Evidence from Large-Scale Radiocarbon Dating.

    Directory of Open Access Journals (Sweden)

    Philipp W Stockhammer

    Full Text Available The transition from the Neolithic to the Early Bronze Age in Central Europe has often been considered as a supra-regional uniform process, which led to the growing mastery of the new bronze technology. Since the 1920s, archaeologists have divided the Early Bronze Age into two chronological phases (Bronze A1 and A2, which were also seen as stages of technical progress. On the basis of the early radiocarbon dates from the cemetery of Singen, southern Germany, the beginning of the Early Bronze Age in Central Europe was originally dated around 2300/2200 BC and the transition to more complex casting techniques (i.e., Bronze A2 around 2000 BC. On the basis of 140 newly radiocarbon dated human remains from Final Neolithic, Early and Middle Bronze Age cemeteries south of Augsburg (Bavaria and a re-dating of ten graves from the cemetery of Singen, we propose a significantly different dating range, which forces us to re-think the traditional relative and absolute chronologies as well as the narrative of technical development. We are now able to date the beginning of the Early Bronze Age to around 2150 BC and its end to around 1700 BC. Moreover, there is no transition between Bronze (Bz A1 and Bronze (Bz A2, but a complete overlap between the type objects of the two phases from 1900-1700 BC. We thus present a revised chronology of the assumed diagnostic type objects of the Early Bronze Age and recommend a radiocarbon-based view on the development of the material culture. Finally, we propose that the traditional phases Bz A1 and Bz A2 do not represent a chronological sequence, but regionally different social phenomena connected to the willingness of local actors to appropriate the new bronze technology.

  14. An Assessment of the Occupational and Environmental Health Needs in Seven Southeastern European and West-Central Asian Countries

    Science.gov (United States)

    Coman, Alexandru; Cherecheş, Răzvan M.; Ungureanu, Marius I.; Vasarhelyi, Emanuela O. Marton; Valentine, Marissa A.; Sabo-Attwood, Tara; Gray, Gregory C.

    2015-01-01

    Eastern European and Central Asian countries are undergoing rapid socioeconomic and political reforms. Many old industrial facilities are either abandoned, or use outdated technologies that severely impact the environment. Emerging industries have less regulation than in developed countries and environmental and occupational problems seem to be increasing. Under a US National Institutes of Health pilot grant, we developed an interdisciplinary One Health research network in Southeastern Europe and West-Central Asia to identify environmental and occupational problems. From 2012–2014, this GEOHealth Hub engaged 11 academic centers and 16 public health institutions in eight different countries: Albania, Armenia, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Romania, and the United States with a goal of strengthening environmental and occupational research and training capacities. Employing face-to-face interviews and large group meetings, we conducted an evidenced-based needs and opportunities assessment focused on aquatic health, food safety, and zoonotic diseases. Comprehensive reviews of published literature yielded priority research areas for each of the seven GeoHealth Hub countries including heavy metal and pesticide contamination, tick-borne diseases, rabies, brucellosis, and inadequate public health surveillance. PMID:25963604

  15. Appreciation of the Swiss Franc and its Impact on Romania and other Central and Eastern European Countries

    Directory of Open Access Journals (Sweden)

    David Delia

    2015-11-01

    Full Text Available The decision of the Swiss National Bank of giving up the fixed rate of 1,2 Euro/CHF on the 15th of January 2015, a rate established at its admission to the Monetary Economic Union, had consequences on Central and Eastern European countries because a great part of the credits granted were in Swiss francs. In all these countries, the national currencies depreciated and the financial market rates were reduced. Regional banks started to face difficulties regarding the management of the situation and were under the necessity of finding solutions to avoid the risk of not recovering the granted credits. The issue of the Swiss franc appreciation was treated differently by the analysed countries and took into consideration the particularities characteristic to the credits granted in this currency. The present paper aims at emphasising the impact of the Swiss franc appreciation on the Romanian banking system but also the approach of other countries in Central and Eastern Europe in this respect.

  16. 19. srednjeevropska konferenca o informatiki in inteligentnih sistemih = 19th Central European Conference on Information and Intelligent Systems

    Directory of Open Access Journals (Sweden)

    Armand Faganel

    2008-12-01

    Full Text Available The aim of the paper is to present the 19th Central European Conference on Information and Intelligent Systems, CECIIS 2008, which took place between 24th and 26th September in Varaždin and was organised by the Faculty of Organisation and Informatics in Varaždin. The central theme of this year’s conference was e-government. During those 3 days, 250 participants could attend presentations of 90 scientific and professional works in 15 sections and 9 invited lectures on the newest trends in the area of information and communication technology management, information technologies, security of information systems, multimedia systems, strategic planning of information systems, education for information society. Two other parallel events were held within the international conference, namely the workshop ‘Activities towards ICT professionalism’ and a round table on the subject ‘Competences of ICT Professionals’. Experts in the field of human resources, leaders of information centres and managers of the leading Croatian companies participated in the latter.

  17. An assessment of the occupational and environmental health needs in seven Southeastern European and West-Central Asian countries.

    Science.gov (United States)

    Coman, Alexandru; Cherecheş, Răzvan M; Ungureanu, Marius I; Marton-Vasarhelyi, Emanuela O; Valentine, Marissa A; Sabo-Attwood, Tara; Gray, Gregory C

    2015-12-01

    Eastern European and Central Asian countries are undergoing rapid socioeconomic and political reforms. Many old industrial facilities are either abandoned, or use outdated technologies that severely impact the environment. Emerging industries have less regulation than in developed countries and environmental and occupational problems seem to be increasing. Under a US National Institutes of Health pilot grant, we developed an interdisciplinary One Health research network in Southeastern Europe and West-Central Asia to identify environmental and occupational problems. From 2012 to 2014, this GeoHealth Hub engaged 11 academic centers and 16 public health institutions in eight different countries: Albania, Armenia, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Romania, and the United States with a goal of strengthening environmental and occupational research and training capacities. Employing face-to-face interviews and large group meetings, we conducted an evidenced-based needs and opportunities assessment focused on aquatic health, food safety, and zoonotic diseases. Comprehensive reviews of the published literature yielded priority research areas for each of the seven GeoHealth Hub countries including heavy metal and pesticide contamination, tick-borne diseases, rabies, brucellosis, and inadequate public health surveillance. Copyright © 2015 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

  18. Where psychology meets physiology: chronic stress and premature mortality--the Central-Eastern European health paradox.

    Science.gov (United States)

    Kopp, Mária S; Réthelyi, János

    2004-02-01

    A substantial and still growing body of research tries to link different psychological models and chronic diseases, with special emphasis on cardiovascular disease. These efforts have established several conceptual bridges that connect psychological alterations and psychosocial factors to the risks, onset and prognosis of cardiovascular disease. However, several different models have been suggested. Depression and learned helplessness are two central psychological models that have been shown to have major explanatory power in the development of chronic diseases. In this respect the so called Central-Eastern European health paradox, that is the morbidity and mortality crisis in these transforming societies can be regarded as a special experimental model. In this review chronic stress is proposed as an integrating theory that can be applied to different psychological models. Chronic stress and allostatic load has been shown to lead to typical pathogenetic results in animal experiments. Chronic stress theory is applicable to the explanation of the suddenly changing patterns of premature mortality rates in transforming societies. Literature and the different models in the field of psychology, behavioural sciences, and epidemiology are reviewed in terms of the chronic stress theory. The applicability of these results are investigated for further research, clinical and policy implications.

  19. Morphology and ecological characteristics of Sparganium × longifolium (Typhaceae in the Central part of European Russia

    Directory of Open Access Journals (Sweden)

    E. A. Belyakov

    2017-05-01

    Full Text Available The increasing impact of anthropogenic factors and climate change affect the growth of a number of taxa of hybrid nature. These taxa are widespread among various taxonomic groups of aquatic and semi-aquatic plants. The genus Sparganium L. В is not an exception. In that regard, the aim of this study is to conduct biomorphological investigation of Sparganium × longifolium Turcz. ex Ledeb., evaluate qualitative and quantitative criteria for the hybrid similarities and differences with its parental species, as well as to analyze data on its habitat characteristics. Samples were collected in 2014–2016 from waterbodies in European Russia (Tver and Yaroslavl oblasts. In the study on biomorphology of S. × longifolium we used live and fixed materials, as well as herbarium funds of IBIW, MXA and MW. To establish and specify taxonomic features of the hybrid under study, indicating to its similarity with a certain ancestral species, our data on the morphology and ecology of S. emersum Rehm. and S. gramineum Georgi. are used. During field studies, the type of water object where the hybrid was detected, ecological characteristics of its habitat (type of soil, depth, water temperature and pH are determined; the list of taxa which enter into the cenosis composition is compiled. The biomorphological investigation of S. × longifolium shows that by life form this hybrid, as well as its parental species, is a vegetative-mobile evidently-polycentric annual or biennial plant of vegetative origin with a racemose root system. The following should be attributed to the characteristic features justifying the hybrid origin of S. × longifolium: 1 a wider, slightly carinated lamina (as in S. emersum; 2 a branched inflorescence (as in S. gramineum; 3 the lower covering leaf of inflorescence, often exceeding the total length of the latter; 4 fruits with a straight (as in S. emersum as well as bent (as in S. gramineum style. Interestingly, some populations of S.

  20. Soil and vegetation under Bison bonasus grazing in the Kaluzhskie Zaseki Reserve (Central European Russia)

    Science.gov (United States)

    Khanina, Larisa; Bobrovsky, Maxim; Shashkov, Maxim; Ivanova, Natalia; Ivashchenko, Kristina

    2017-04-01

    Plant diversity and soil characteristics including soil macrofauna and microbial biomass were studied in two areas of the Reserve affected by grazing of semi-free-ranging European bison population during the decade. The study areas are surrounded by broad-leaved forest co-dominated by Quercus robur, Fraxinus excelsior, Tilia cordata, Ulmus glabra, Acer platanoides and A. campestre. Aiming to assess impacts of the bison population on soil and vegetation, we studied two series of conjugated biotopes: (1) a meadow with feeder, (2) a transition zone: the forest edge with damaged tree trunks, trampled soil and fragmented ground vegetation and (3) a forest without visible signs of bison activities. One biotope series was located on loamy soils and other one on sandy-loams. The following samplings of soil and vegetation were conducted in each biotope in two areas: (1) plant species list with their coverage in three vegetation layers in 5 square plots of 100 m2 was compiled; (2) earthworms were sampled in 8 monoliths of 25x25x35 cm and handy sorted to estimate earthworm diversity, number and biomass; (3) soil was also sampled from 0 to 10 cm soil depths with 4 replications to estimate soil physico-chemical characteristics and soil microbial biomass. Preliminary results showed relatively high ecological difference of the areas on loams and sandy-loams: soil on loams was richer in the main chemical elements, such as C, N, Ca and K. At that, in both areas, meadow soils were richer than forest soils in C, N, Ca, P and K. The highest values of C and N were observed in the transition zones and they were closed to values observed in the meadow soils. Total amount of exchangeable cations and Ca most strongly decreased from meadow to forest soils with the intermediate values in the transition zones. Despite the ecological differences of the areas, paired biotopes were similar to each other in structure of vegetation communities. For 10 years of grazing, forest vegetation was

  1. Breast cancer patients in Libya: Comparison with European and central African patients

    Science.gov (United States)

    BODER, JAMELA MOSTAFA E.; ELMABROUK ABDALLA, FATHI B.; ELFAGEIH, MOHAMED AHMED; ABUSAA, ABUAGELA; BUHMEIDA, ABDELBASET; COLLAN, YRJÖ

    2011-01-01

    The present study evaluated the incidence of breast cancer in Libya and described the clinicopathological and demographic features. These features were then compared with corresponding data from patients from sub-Saharan Africa (Nigeria) and Europe (Finland). The study consisted of 234 patients with breast carcinoma, admitted to the African Oncology Institute in Sabratha, Libya, during the years 2002–2006. The pathological features were collected from pathology reports, patient histories from hospital files and the Sabratha Cancer Registry. The demographic differences between the Libyan, Nigerian and Finnish populations were prominent. The mean age of breast cancer patients in Libya was 46 years which was almost identical to that of Nigeria, but much lower than that of Finland. The Libyan breast cancer incidence was evaluated as 18.8 per 100,000 female individuals. This incidence was markedly higher in Finland, but was also high in Nigeria. Libyan and Nigerian breast cancer is predominantly of premenopausal type and exhibits unfavorable characteristics such as high histological grade and stage, large tumor size and frequent lymph node metastases. However, the histological types and histopathological risk features show similar importance regarding survival as European breast cancer cases. Survival in Libya ranks between the rates of survival in Nigeria (lowest) and Finland (highest). In conclusion, in Libya and other African countries, premenopausal breast cancer is more common than postmenopausal breast cancer. However, the opposite is true for Europe. Population differences may be involved, as suggested by the known variation, in the distribution of genetic markers in these populations. Different types of environmental impacts, however, cannot be excluded. PMID:22866085

  2. GDP, Time Allocation and Annual Time Worked Per Adult in Central and Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Jacek Jankiewicz

    2017-06-01

    Full Text Available When decisions taken in the context of monetary price and monetary income are investigated, economists have naturally tended to focus their attention on the market activities of households. Consequently, a significant portion of the economic decisions that are taken in the non-market sphere have remained overlooked. Thus it has been recognised that it is necessary to take into account the production generated by households in the measurement of economic wealth. The aim of this paper is to analyse differences in the economic activity of selected Central and Eastern Europe societies. The use of traditional statistics and time-use data for this purpose made it possible to compare the conclusions that can be drawn using different sources of information. As the statistical material has been supplemented with time-use data, prior conclusions about creating the economic welfare of these societies needed to be modified. The different allocations of time in the individual societies and the different extents to which household production is substituted by market goods and services have an impact on the level of prosperity of households. The significant differences in terms of compensating for market work with household production which were observed when comparing the daily activity of unemployed men and women, turned out to be a common feature of the analysed populations.

  3. Survey of otolaryngology services in Ukraine and neighbouring Central and Eastern European countries.

    Science.gov (United States)

    Verkerk, M M; Wagner, R; Fishchuk, R; Fagan, J J

    2017-11-01

    The present humanitarian crisis in Ukraine is putting strains on its healthcare system. This study aimed to assess services and training in otolaryngology, audiology and speech therapy in Ukraine and its geographical neighbours. Survey study of 327 otolaryngologists from 19 countries. Fifty-six otolaryngologists (17 per cent) from 15 countries responded. Numbers of otolaryngologists varied from 3.6 to 12.3 per 100 000 population (Ukraine = 7.8). Numbers of audiologists varied from 0, in Ukraine, to 2.8 per 100 000, in Slovakia, and numbers of speech therapists varied from 0, in Bulgaria, to 4.0 per 100 000, in Slovenia (Ukraine = 0.1). Ukraine lacks newborn and school hearing screening, good availability of otological drills and microscopes, and a cochlear implant programme. There is wide variation in otolaryngology services in Central and Eastern Europe. All countries surveyed had more otolaryngologists per capita than the UK, but availability of audiology and speech and language therapy is poor. Further research on otolaryngology health outcomes in the region will guide service improvement.

  4. The lending channel and budget balance: empirical evidences from Central and Eastern European economies

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    Bogdan-Gabriel MOINESCU

    2013-03-01

    Full Text Available The study aims to deepen the analysis on the indirect dependence of government budget balance on private sector credit flow in the countries of Central and Eastern Europe. The added value of this approach consists of two elements. First, the analysis suggests developing the traditional analytical framework of assessing risks to public finance stability by including second round effects of negative fiscal impulses on credit to private sector during recession periods. Second, the study provides empirical evidence on the importance of economic growth transmission channel for the impact of credit accelerator effects on primary deficit. At the same time, nonperforming loans channel proved to be insignificant, especially in relation to the persistency of last year’s budget deficit and the effects of budget allocations pro-cyclicality. However, loan portfolio quality seems to be more relevant in the case of public debt service, through its influence on the evolution of the yield on long-term government securities that is closely related to sovereign risk premium. Nevertheless, strengthening the financial safety net by the introduction of resolution funds will most probably break the link investors saw between credit portfolio quality and the impending increase in budget spending. This expected development across not only CEE countries, but at the EU level also, will facilitate the isolation of sovereign risk premium from non-performing loans’ dynamics.

  5. Specifics of IFRS Adoption by Central and Eastern European Countries: Evidence from Research

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    Procházka David

    2017-03-01

    Full Text Available The paper reviews recent literature on the specifics of adoption of International Financial Reporting Standards (IFRS by the new EU members from the Central and Eastern Europe. Despite being members of the EU or OECD, the transition to a standard developed economy has not yet finished. The first part of the paper presents macroeconomic statistics and capital market data, which underline a unique economic structure of the region (relative unimportance of capital markets for raising capital, strong dependence on foreign direct investments combined with the lacks in institutional environment. Under such conditions, the economic consequences of IFRS adoption can be unpredictable and adverse. The second part of the paper analyses the reflection of specifics of the IFRS adoption in the CEE region in research studies covered by the Thomson Reuters’ Web of Science database. The analysis reveals (a cross-country disproportion in the research coverage of the area; (b relatively low coverage of the IFRS research focusing on these transition countries in top journals.

  6. Spontaneous vegetation succession at different central European mining sites: a comparison across seres.

    Science.gov (United States)

    Prach, Karel; Lencová, Kamila; Rehounková, Klára; Dvořáková, Helena; Jírová, Alena; Konvalinková, Petra; Mudrák, Ondřej; Novák, Jan; Trnková, Romana

    2013-11-01

    We performed detrended correspondence analysis (DCA) ordination to compare seven successional seres running in stone quarries, coal mining spoil heaps, sand and gravel pits, and extracted peatlands in the Czech Republic in central Europe. In total, we obtained 1,187 vegetation samples containing 705 species. These represent various successional stages aged from 1 to 100 years. The successional seres studied were more similar in their species composition in the initial stages, in which synathropic species prevailed, than in later successional stages. This vegetation differentiation was determined especially by local moisture conditions. In most cases, succession led to a woodland, which usually established after approximately 20 years. In very dry or wet places, by contrast, where woody species were limited, often highly valuable, open vegetation developed. Except in the peatlands, the total number of species and the number of target species increased during succession. Participation of invasive aliens was mostly unimportant. Spontaneous vegetation succession generally appears to be an ecologically suitable and cheap way of ecosystem restoration of heavily disturbed sites. It should, therefore, be preferred over technical reclamation.

  7. The Impact of International Financial Crisis on Bank Performance in Eastern and Central European Countries

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    Alin-Marius Andrieș

    2016-05-01

    Full Text Available In this paper we investigate the determinants of bank profitability in 10 countries from Central and Eastern Europe, in the period between 2004 and 2013. We proxy the profitability of banks with more commonly used ratio: the return on assets (ROA, computed as a ratio of the net profit to the total bank assets. We used multiple regression with bank specific variables, banking industry variables and macroeconomic variables. Moreover, we added a global financial crisis dummy to highlight the crisis impact on asset return. OLS is the main estimation method, but we also used difference-in-difference in order to test if the crisis impact was amplified or diminished by the bank specific characteristics. The evidence shows significant differences between the profit levels of the CEEC banks. Our results are in line with the empirical literature. The impact of the international financial crisis on ROA was negative and statistically significant, as expected. The second part of the analysis we separate the banks sample in three categories: banks with high capital adequacy, large banks by total assets and foreign-owned banks. Our findings show that the three selected variables both amplified and decreased the crisis effect.

  8. The peculiarities of trade specialization in creative industries in the Central and Eastern European countries

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    Veronika CHALA

    2015-06-01

    Full Text Available Because of dynamic processes of creative economy development and resistance to the crisis of modern creative industries which occurs mainly in metropolitan areas, the interest in understanding these local processes as a factor of bringing international trade competitiveness and providing convergence among the countries where those metropolises are situated is of great value. The EU, and Central and East Europe (CEE in particular, is not an exception. This paper reveals the most productive creative industries in the EU; fins out the impact of metropolises’ creative activities development on countries’ international specialization. Perspective products’ and geographic patterns relating creative products’ international specialization for CEE countries, especially for those which have recently signed association agreements with the EU (Moldova, Ukraine, and Georgia as an important East Neighbour for the EU are grounded. Using inter- and intra-trading estimations, the positioning of CEE countries in the EU 28(+3 international specialization pattern is indicated. The product specialization of metropolises in CEE countries which may (or may not contribute to further internationalization of creative industries in these countries has been revealed in the article.

  9. Dissecting the genetic architecture of frost tolerance in Central European winter wheat.

    Science.gov (United States)

    Zhao, Yusheng; Gowda, Manje; Würschum, Tobias; Longin, C Friedrich H; Korzun, Viktor; Kollers, Sonja; Schachschneider, Ralf; Zeng, Jian; Fernando, Rohan; Dubcovsky, Jorge; Reif, Jochen C

    2013-11-01

    Abiotic stress tolerance in plants is pivotal to increase yield stability, but its genetic basis is still poorly understood. To gain insight into the genetic architecture of frost tolerance, this work evaluated a large mapping population of 1739 wheat (Triticum aestivum L.) lines and hybrids adapted to Central Europe in field trials in Germany and fingerprinted the lines with a 9000 single-nucleotide polymorphism array. Additive effects prevailed over dominance effects. A two-dimensional genome scan revealed the presence of epistatic effects. Genome-wide association mapping in combination with a robust cross-validation strategy identified one frost tolerance locus with a major effect located on chromosome 5B. This locus was not in linkage disequilibrium with the known frost loci Fr-B1 and Fr-B2. The use of the detected diagnostic markers on chromosome 5B, however, does not allow prediction of frost tolerance with high accuracy. Application of genome-wide selection approaches that take into account also loci with small effect sizes considerably improved prediction of the genetic variation of frost tolerance in wheat. The developed prediction model is valuable for improving frost tolerance because this trait displays a wide variation in occurrence across years and is therefore a difficult target for conventional phenotypic selection.

  10. Effect of culling and vaccination on bovine tuberculosis infection in a European badger (Meles meles) population by spatial simulation modelling

    NARCIS (Netherlands)

    Abdou, Marwa; Frankena, Klaas; O'Keeffe, James; Byrne, Andrew W.

    2016-01-01

    The control of bovine tuberculosis (bTB) in cattle herds in the Republic of Ireland (ROI) is partially hindered by spill-back infection from wild badgers (Meles meles). The aim of this study was to determine the relative effects of interventions (combinations of culling and/or vaccination) on bTB

  11. Infection and transmission of live recombinant Newcastle disease virus vaccines in Rock Pigeons, European House Sparrows, and Japanese Quail

    Science.gov (United States)

    In China and Mexico, engineered recombinant Newcastle disease virus (rNDV) strains are used as live vaccines for the control of Newcastle disease and as vectors to express the avian influenza virus hemagglutinin (HA) gene to control avian influenza in poultry. In this study, non-target species wer...

  12. Soil greenhouse gases fluxes in forest - fallow succession at the Central Forest Reserve in European Russia

    Science.gov (United States)

    Komarova, Tatiana; Vasenev, Ivan

    2017-04-01

    One of the principal factors influencing the current level of the greenhouse fluxes are land-use changes, including the forest restoration in fallow lands, which is widespread at the Central Region of Russia. The comprehensive environmental studies of soil greenhouse fluxes have been done in comparable sites with different stages of the forest-fallow successions in the southern part of the Central Forest Reserve with spruce domination in the mature forest - representative southern-taiga ecosystems. Seasonal and diurnal dynamics CO2 fluxes measurements were carried out in situ using a mobile gas analyzer Li-820 with soil exposure chambers and parallel observation of air temperature, soil temperature and moisture. Also, every ten days the soil air has been sampled in the vials for further CO2, CH4 and N2O flux measurements by the stationary gas chromatograph. Within forest-fallow successions there are shown the litter gradual development, humus-accumulative horizon differentiation, soil acidity and bulk density increasing. At the same time there is enough obvious in the down part of past-arable horizon gradual restoration of the podzolic horizon. The monitoring results have shown the essential decreasing of soil CO2 fluxes (in 2 times) in frame of successions. The maximum CO2 fluxes have been fixed in July with optimal soil temperature/moisture ratio. In the middle of July the maximum CO2 emission is observed in fallow grassland (34,1 g CO2 / m2day), that is almost in 2-times more than in spruce-forest after fallow stage of 120-150 years. It is important that soil CO2 fluxes essentially increase with soil temperature rise (with up to R = 0,75) and drop soil moisture (with up to R = - 0,66). During the day, the most intense soil CO2 fluxes have been observed from case of 12:00 to 18:00. The maximum CO2 flux has been recorded at 15:00 in the fallow grassland (23 g CO2 / m2 day). In the forest-fallow stage of 10-15 years the maximum soil CO2 flux observed at 12 hours

  13. The Competitiveness of Settlements with SPAS in Some Central European Regions

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    Márta Bakucz

    2016-04-01

    Full Text Available The paper covers two topics which are, broadly, inseparable. The first has as its main target the competitiveness of Spa Tourism in two Regions of Hungary - in settlements with different characteristics; the second, recognising the need for a new way to measure competitiveness in the sector, deals with the creation of a new competitiveness index. The benefits of virtually all forms of Tourism - economic or social – are well enough known to need no repetition. This is especially true of such fields as Spa or Health Tourism, in which there is a natural trend towards longer stays and higher expenditure by visitors. For a relatively poor country such as Hungary – weak in natural resources apart from agricultural land – the basic presence of a generous supply of easily accessible thermal or medicinal water below a huge proportion of its surface area (70% is a remarkable gift. Nevertheless, many factors are to be studied if a rational, sustainable development policy is to be elaborated by public and private interests. There are many spas – settlements with thermal or medicinal waters (or both - spread across Hungary, and their variety is extraordinary. There are huge differences in terms of size, visitor numbers, accommodation facilities, overnights, leisure or treatment facilities and location – that is, their closeness to favourable population areas (domestic or foreign. The critical decisions on investment and development need comprehensive data on all factors of all locations. The essential issue is competitiveness: in Central Europe, where spas have a great tradition and history (e.g., Germany, Austria and today’s Czech Republic, does or can Hungary offer a product which will sell? There are numerous factors and as many bases on which to judge. In 2013 a team from the Faculty of Business and Economics at Pécs University - supported by Hungary’s National Scientific Research Foundation (OTKA – embarked on a study of the

  14. Barriers to accessing adequate maternal care in Central and Eastern European countries: A systematic literature review.

    Science.gov (United States)

    Miteniece, Elina; Pavlova, Milena; Rechel, Bernd; Groot, Wim

    2017-03-01

    Maternal health outcomes in Central and Eastern Europe (CEE) compare unfavorable with those in Western Europe, despite macro-indicators that suggest well-designed maternal care systems. However, macro-indicators at the system level only capture capacity, funding and utilization of care and not the actual allocation of financial and human resources, the quality of care and access to it. It is these latter which are problematic in the CEE region. In this study service-related indicators of access to maternal care in CEE are examined. These include availability, appropriateness, affordability, approachability and acceptability of maternal care. This study uses a qualitative systematic literature review, analyzing information of peer-reviewed articles published since 2004. Other inclusion criteria included language, setting and publication purpose. The included articles were analyzed using a framework analysis technique and quality was assessed using standardized evaluation checklists. Results indicate improvements in maternal care. However, availability of care is limited by outdated equipment and training curricula, and the lack of professionals and pharmaceuticals. Geographical distance to healthcare institutions, inappropriate communication of providers and waiting times are the main approachability barriers. Some mothers are unaware of the importance of care or are discouraged to utilize healthcare services because of cultural aspects. Finally, a major barrier in accessing maternal care in the CEE is the inability to pay for it. Our findings indicate that major gaps in evidence exist and that more representative and better quality data should be collected. Governments in CEE countries need to establish a reliable system for measuring and monitoring a suitable set of indicators, as well as deal with the general social and economic problem of informality. Medical curricula in the CEE region need to be overhauled and there should be a focus on improving the

  15. The wind and fire disturbance in Central European mountain spruce forests: the regeneration after four years

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    Monika Budzáková

    2013-03-01

    Full Text Available A strong windstorm in November 2004 resulted in a huge blown-down spruce forest area in the southern part of the Tatra National Park in the Western Carpathians in Slovakia, Central Europe. The aim of this work is to study the vegetation composition of spruce forest at differently managed sites four years after this disturbance. Four study areas were selected for this purpose: (i an area where the fallen trees were extracted and new seedlings were planted; (ii an area, which was hit by a forest fire after the extraction; (iii an area where no active management was applied; (iv a reference forest unaffected by such disturbance. A total of 100 plots were selected, 25 of each area type. The result of DCA and CCA analyses consistently indicated that after this short period the non-extracted and extracted areas are currently most similar to the reference forest area, while the fire affected area differed. A one-way ANOVA comparing species cover for the different plot sizes indicated some significant differences between the extracted and non-extracted plots. The abundance of certain species commonly occurring in spruce forests, such as Dyopteris carthusiana agg., Vaccinium myrtillus and Avenella flexuosa, correlated weli with the non-extracted plots, compared to the extracted plots. Coverage of these species was lowest on burned plots. The lowest Shannon-Wiener’s diversity values were recorded in burned plots. This was most likely a consequence of mono-dominant competitive species spread, (mainly Chamerion angustifolium which profited from the altered ecological conditions following the fire. Although some differences were also registered in the Shannon-Wiener diversity index between the remaining research plots, however these were not statistically significant. The most important results of our investigations include the extensive influence of fire disturbance on vegetation. Study revealed that the wind-disturbed area is able to regenerate

  16. Water shortage affects the water and nitrogen balance in Central European beech forests.

    Science.gov (United States)

    Gessler, A; Keitel, C; Nahm, M; Rennenberg, H

    2004-05-01

    Whilst forest policy promotes cultivation and regeneration of beech dominated forest ecosystems, beech itself is a highly drought sensitive tree species likely to suffer from the climatic conditions prognosticated for the current century. Taking advantage of model ecosystems with cool-moist and warm-dry local climate, the latter assumed to be representative for future climatic conditions, the effects of climate and silvicultural treatment (different thinning regimes) on water status, nitrogen balance and growth parameters of adult beech trees and beech regeneration in the understorey were assessed. In addition, validation experiments with beech seedlings were carried out under controlled conditions, mainly in order to assess the effect of drought on the competitive abilities of beech. As measures of water availability xylem flow, shoot water potential, stomatal conductance as well as delta (13)C and delta (18)O in different tissues (leaves, phloem, wood) were analysed. For the assessment of nitrogen balance we determined the uptake of inorganic nitrogen by the roots as well as total N content and soluble N compounds in different tissues of adult and young trees. Retrospective and current analysis of delta (13)C, growth and meteorological parameters revealed that beech growing under warm-dry climatic conditions were impaired in growth and water balance during periods with low rain-fall. Thinning affected water, N balance and growth mostly of young beech, but in a different way under different local climatic conditions. Under cool, moist conditions, representative for the current climatic and edaphic conditions in beech forests of Central Europe, thinning improves nutrient and water status consistent to published literature and long-term experience of forest practitioners. However, beech regeneration was impaired as a result of thinning at higher temperatures and under reduced water availability, as expected in future climate.

  17. A MACROPRUDENTIAL SUPERVISION MODEL. EMPIRICAL EVIDENCE FROM THE CENTRAL AND EASTERN EUROPEAN BANKING SYSTEM

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    Trenca Ioan

    2013-07-01

    Full Text Available One of the positive effects of the financial crises is the increasing concern of the supervisors regarding the financial system’s stability. There is a need to strengthen the links between different financial components of the financial system and the macroeconomic environment. Banking systems that have an adequate capitalization and liquidity level may face easier economic and financial shocks. The purpose of this empirical study is to identify the main determinants of the banking system’s stability and soundness in the Central and Eastern Europe countries. We asses the impact of different macroeconomic variables on the quality of capital and liquidity conditions and examine the behaviour of these financial stability indicators, by analyzing a sample of 10 banking systems during 2000-2011. The availability of banking capital signals the banking system’s resiliency to shocks. Capital adequacy ratio is the main indicator used to assess the banking fragility. One of the causes of the 2008-2009 financial crisis was the lack of liquidity in the banking system which led to the collapse of several banking institutions and macroeconomic imbalances. Given the importance of liquidity for the banking system, we propose several models in order to determine the macroeconomic variables that have a significant influence on the liquid reserves to total assets ratio. We found evidence that GDP growth, inflation, domestic credit to private sector, as well as the money and quasi money aggregate indicator have significant impact on the banking stability. The empirical regression confirms the high level of interdependence of the real sector with the financial-banking sector. Also, they prove the necessity for an effective macro prudential supervision at country level which enables the supervisory authorities to have an adequate control over the macro prudential indicators and to take appropriate decisions at the right time.

  18. Family-friendly policy in Central European countries [Polityka rodzinna w krajach Europy Środkowej

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    Mirosław ZDULSKI

    2016-06-01

    Full Text Available The demographic changes in Central Europe which started in the 80s of the 20th century began to resemble the changes which were noticed earlier in the countries of Western Europe. Fertility gradually decreased, sometimes even below the simple reproduction rate, the number of marriages dropped and the age when they were made was changing. The model of the family underwent transformations which caused changes in family structures. What followed was a fast change from the so called traditional reproduction to modern reproduction. Demographers are looking for the causes of the above mentioned changes in the influence of economic factors and changes the world view. They also emphasised the need for a family-friendly policy. An important influence on the type of policy of a given country is tradition, the implemented socio-economic policy (e.g., conservative, liberal, the economic situation and public opinion. In a narrower sense it is defined as benefits and services for people with children and single parents. Such an approach means the readiness and constant support in the form of financial transfers made to the families, tax relief for families with children, maternity leaves, the creation and maintenance of institutions which offer child care and family law. In a broad sense, familyfriendly policy covers all areas of social policy which can potentially have an influence on the good of the family (subsidies towards children’s travel costs, education, safety, housing, etc.. The aim of this paper is to describe the changes in the field of demography which took place after 1989 and their effects on families, as well as the policies implemented in the Czech Republic, Poland, Slovakia and Hungary in order to increase reproduction and the number of marriages.

  19. Uptake of influenza vaccination, awareness and its associated barriers among medical students of a University Hospital in Central Saudi Arabia.

    Science.gov (United States)

    Abalkhail, Mohammed S; Alzahrany, Mohannad S; Alghamdi, Khaled A; Alsoliman, Muath A; Alzahrani, Mosa A; Almosned, Badr S; Gosadi, Ibrahim M; Tharkar, Shabana

    Outbreaks of influenza epidemics are common but influenza vaccination is sub-optimal among the healthcare staff including the medical students. The study aims to assess the rate of vaccine uptake among medical students, its associated barriers and levels of awareness. A cross sectional study was done at a University Hospital in Saudi Arabia on 421 medical students by self administered questionnaire from February to March 2015. The immunization rate of seasonal influenza vaccine was just 20.7% in 2015, while it was 57% for cumulative of previous three-year period. The intended uptake among those offered vaccination was 68%. The significant determinants of vaccine uptake were clinical years of medical study (psocial and media influence. Barriers of vaccination constituted, assumption of not being at risk of influenza (37.9%), vaccine side effects (28.9%), questioned effectiveness of the vaccine (14.5%), and inability to allocate time (11%). Knowledge levels were unsatisfactory and males scored lower (5.4±1.7) than females (6.5±1.4) out of total score of 9. Both knowledge and uptake of annual influenza vaccination was inadequate. Policy makers can formulate strategies with a focus on larger coverage of medical students. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  20. Divergent selection along climatic gradients in a rare central European endemic species, Saxifraga sponhemica.

    Science.gov (United States)

    Walisch, Tania J; Colling, Guy; Bodenseh, Melanie; Matthies, Diethart

    2015-06-01

    The effects of habitat fragmentation on quantitative genetic variation in plant populations are still poorly known. Saxifraga sponhemica is a rare endemic of Central Europe with a disjunct distribution, and a stable and specialized habitat of treeless screes and cliffs. This study therefore used S. sponhemica as a model species to compare quantitative and molecular variation in order to explore (1) the relative importance of drift and selection in shaping the distribution of quantitative genetic variation along climatic gradients; (2) the relationship between plant fitness, quantitative genetic variation, molecular genetic variation and population size; and (3) the relationship between the differentiation of a trait among populations and its evolvability. Genetic variation within and among 22 populations from the whole distribution area of S. sponhemica was studied using RAPD (random amplified polymorphic DNA) markers, and climatic variables were obtained for each site. Seeds were collected from each population and germinated, and seedlings were transplanted into a common garden for determination of variation in plant traits. In contrast to previous results from rare plant species, strong evidence was found for divergent selection. Most population trait means of S. sponhemica were significantly related to climate gradients, indicating adaptation. Quantitative genetic differentiation increased with geographical distance, even when neutral molecular divergence was controlled for, and QST exceeded FST for some traits. The evolvability of traits was negatively correlated with the degree of differentiation among populations (QST), i.e. traits under strong selection showed little genetic variation within populations. The evolutionary potential of a population was not related to its size, the performance of the population or its neutral genetic diversity. However, performance in the common garden was lower for plants from populations with reduced molecular genetic

  1. Pharmaceutical Regulation in Central and Eastern European Countries: A Current Review

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    Paweł Kawalec

    2017-12-01

    Full Text Available Objectives: The aim of this study was to review reimbursement environment as well as pricing and reimbursement requirements for drugs in selected Central and Eastern Europe (CEE countries.Methods: A questionnaire-based survey was performed in the period from November 2016 to March 2017 among experts involved in reimbursement matters from CEE countries: Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia, and Romania. A review of requirements for reimbursement and implications of Health Technology Assessment (HTA was performed to compare the issues in above-mentioned countries. For each specified country, data for reimbursement costs, total pharmaceutical budget, and total public health care budget in the years 2014 and 2015 were also collected. Questionnaires were distributed via emails and feedback data were obtained in the same way. Additional questions, if any, were also submitted to respondents by email. Pricing and reimbursement data were valid for March 2017.Results: The survey revealed that the relation of drug reimbursement costs to total public healthcare spending ranged from 0.12 to 0.21 in the year 2014 and 2015 (median value. It also revealed that pricing criteria for drugs, employed in the CEE countries, were quite similar. External reference pricing as well as internal reference pricing were common in mentioned countries. Positive reimbursement lists were valid in all countries of the CEE region, negative ones were rarely used; reimbursement decisions were regularly revised and updated in the majority of countries. Copayment was common and available levels of reimbursement differed within and between the countries and ranged from 20 to 100%. Risk-sharing schemes were often in use, especially in the case of innovative, expensive drugs. Generic substitution was also possible in all analyzed CEE countries, while some made it mandatory. HTA was carried out in almost all of the considered CEE

  2. Road dust emission profiles and levels from paved road in Mediterranean and central European cities

    Science.gov (United States)

    Amato, F.; Furger, M.; Pandolfi, M.; Querol, X.; Alastuey, A.; Bukowiecki, N.; Gehrig, R.; Richard, A.; Prevot, A. S. H.; Baltensperger, U.

    2009-04-01

    The burden of road dust re-suspension on urban air quality varies depending on several local factors such as precipitation rate, vehicle fleets and state of pavement. In Mediterranean cities emissions from traffic re-suspension can be comparable or even higher than direct exhaust emissions while in central Europe precipitation helps in maintaining street cleaning, reducing re-suspension. Receptor models are useful tools to estimate the contribution of urban re-suspension to PM. Target factor analysis and chemical mass balance can be successfully applied but a key task for the application of the aforementioned models is obtaining valid emission profiles for road dust re-suspended by traffic re-suspension. In this study two different campaigns were carried out in Zurich (February 2008) and Barcelona (June 2007) in order to estimate the load and chemical properties of road dust in two dissimilar urban environments. To this aim 7 and 9 locations were selected in Zurich (CH) and Barcelona (E) city centers respectively. Samplings were performed by means of a field re-suspension chamber, collecting into filters the PM10 fraction of deposited materials from one square meter of active traffic lanes (Amato et al., 2009). The sampling sites selected for this study had different traffic loads (from background to major roads) allowing to evaluate the impact of traffic to the levels of pollutants, especially those from brake wear such as Sb, Cu, Zn, Ba, and Fe among others. In Zurich the levels of deposited PM10 (0.2-1.3 mg/m2) were lower than in Barcelona (3.7-23.1 mg/m2) where levels were mainly controlled by the dust handling at kerbside works and uncovered transport by trucks. Such dust accretion, favoured by the lack of rain, increases re-suspension. This process is likely to be the main cause of the high atmospheric mineral matter in the urban background of Barcelona (31%), rather than in Zurich (10%) where PM10 mass is dominated by secondary inorganic aerosols (37%) and

  3. Construction of Gridded Daily Weather Data and its Use in Central-European Agroclimatic Study

    Science.gov (United States)

    Dubrovsky, M.; Trnka, M.; Skalak, P.

    2013-12-01

    series (e.g. probability of wet day occurrence and lag-1 autocorrelation of daily mean temperature). The WG-friendly scenarios for the present experiment are based on comparison of future vs baseline surface weather series simulated by GCMs from a CMIP3 database. The second part will present results of climate change impact study based on an above methodology applied to Central Europe. The changes in selected climatic (focusing on the extreme precipitation and temperature characteristics) and agroclimatic (including number of days during vegetation season with heat and drought stresses) characteristics will be analysed. In discussing the results, the emphasis will be put on 'added value' of various aspects of above methodology (e.g. inclusion of changes in 'advanced' WG parameters into the climate change scenarios). Acknowledgements: The present experiment is made within the frame of projects WG4VALUE (project LD12029 sponsored by the Ministry of Education, Youth and Sports of CR), ALARO-Climate (project P209/11/2405 sponsored by the Czech Science Foundation), and VALUE (COST ES 1102 action).

  4. Combination vaccines

    Directory of Open Access Journals (Sweden)

    David AG Skibinski

    2011-01-01

    Full Text Available The combination of diphtheria, tetanus, and pertussis vaccines into a single product has been central to the protection of the pediatric population over the past 50 years. The addition of inactivated polio, Haemophilus influenzae, and hepatitis B vaccines into the combination has facilitated the introduction of these vaccines into recommended immunization schedules by reducing the number of injections required and has therefore increased immunization compliance. However, the development of these combinations encountered numerous challenges, including the reduced response to Haemophilus influenzae vaccine when given in combination; the need to consolidate the differences in the immunization schedule (hepatitis B; and the need to improve the safety profile of the diphtheria, tetanus, and pertussis combination. Here, we review these challenges and also discuss future prospects for combination vaccines.

  5. Incidence of rotavirus gastroenteritis by age in African, Asian and European children: Relevance for timing of rotavirus vaccination

    Science.gov (United States)

    Steele, A. Duncan; Madhi, Shabir A.; Cunliffe, Nigel A.; Vesikari, Timo; Phua, Kong Boo; Lim, Fong Seng; Nelson, E. Anthony S.; Lau, Yu-Lung; Huang, Li-Min; Karkada, Naveen; Debrus, Serge; Han, Htay Htay; Benninghoff, Bernd

    2016-01-01

    ABSTRACT Variability in rotavirus gastroenteritis (RVGE) epidemiology can influence the optimal vaccination schedule. We evaluated regional trends in the age of RVGE episodes in low- to middle- versus high-income countries in three continents. We undertook a post-hoc analysis based on efficacy trials of a human rotavirus vaccine (HRV; Rotarix™, GSK Vaccines), in which 1348, 1641, and 5250 healthy infants received a placebo in Europe (NCT00140686), Africa (NCT00241644), and Asia (NCT00197210, NCT00329745). Incidence of any/severe RVGE by age at onset was evaluated by active surveillance over the first two years of life. Severity of RVGE episodes was assessed using the Vesikari-scale. The incidence of any RVGE in Africa was higher than in Europe during the first year of life (≤2.78% vs. ≤2.03% per month), but much lower during the second one (≤0.86% versus ≤2.00% per month). The incidence of severe RVGE in Africa was slightly lower than in Europe during the first year of life. Nevertheless, temporal profiles for the incidence of severe RVGE in Africa and Europe during the first (≤1.00% and ≤1.23% per month) and second (≤0.53% and ≤1.13% per month) years of life were similar to those of any RVGE. Any/severe RVGE incidences peaked at younger ages in Africa vs. Europe. In high-income Asian regions, severe RVGE incidence (≤0.31% per month) remained low during the study. The burden of any RVGE was higher earlier in life in children from low- to middle- compared with high-income countries. Differing rotavirus vaccine schedules are likely warranted to maximize protection in different settings. PMID:27260009

  6. The Effects of Detritus Input on Soil Organic Matter Content and Carbon Dioxide Emission in a Central European Deciduous Forest

    Directory of Open Access Journals (Sweden)

    FEKETE, István

    2011-01-01

    Full Text Available A major objective of our research was to survey soil biological activity and organic mattercontent reduction in a Central European oak forest during treatments of various detritus inputs within theSíkfkút DIRT (Detritus Input and Removal Treatments Project. Beside the control, three detritusremoval and two detritus duplication treatments were applied. Our examinations have proven that soilorganic matter content declined relatively fast in detritus removal treatments. The reduction wasespecially remarkable in root detritus removal treatments, where – due to the lack of transpiration – soilswere moister during the whole year than in the other treatments. The higher moisture content, despite ofthe reduction of detritus input, produced an intense soil respiration. This can be explained by the fact thatdecomposing organisms have increased the use of soil organic matter. Detritus input reduction had asignificantly greater effect on soil respiration and organic matter content than detritus input duplicationof the same extent. The latter did not cause any significant change compared to the control.

  7. Changing prevalence patterns in endoscopic and histological diagnosis of gastritis? Data from a cross-sectional Central European multicentre study.

    Science.gov (United States)

    Wolf, Eva-Maria; Plieschnegger, Wolfgang; Geppert, Michael; Wigginghaus, Bernd; Höss, Gabriele M; Eherer, Andreas; Schneider, Nora I; Hauer, Almuthe; Rehak, Peter; Vieth, Michael; Langner, Cord

    2014-05-01

    Traditionally, Helicobacter infection is considered to be the most common cause of gastritis. In the cross-sectional Central European histoGERD trial, we assessed the prevalence of different types of gastritis, correlating histological and endoscopic diagnoses. A total of 1123 individuals participated in an observational multicentre study. Endoscopists classified individuals as positive or negative for gastritis and rendered the putative cause. Pathologists evaluated biopsy specimens based upon the Updated Sydney System. Histological diagnosis of gastritis was made in 639 (56.9%) participants. In all, 210 (18.7%) individuals were diagnosed with Helicobacter gastritis, 215 (19.1%) with post Helicobacter gastritis, 234 (20.8%) with reactive gastropathy, 26 (2.3%) with autoimmune gastritis, and 6 (0.5%) with focally enhanced gastritis related to Crohn's disease. In 46 out of 639 (7.2%) individuals diagnosed with gastritis, combinations of different histological subtypes were noted the most common being reactive gastropathy and post Helicobacter gastritis. Endoscopic diagnosis of gastritis was made in 534 (47.6%) individuals. Reactive gastropathy was more common than active Helicobacter gastritis, and the majority of cases attributable to Helicobacter infection were no longer ongoing, i.e. post Helicobacter gastritis. Agreement between histological and endoscopic diagnoses was better in reactive gastropathy than in Helicobacter gastritis. Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  8. Population Trends of Central European Montane Birds Provide Evidence for Adverse Impacts of Climate Change on High-Altitude Species.

    Science.gov (United States)

    Flousek, Jiří; Telenský, Tomáš; Hanzelka, Jan; Reif, Jiří

    2015-01-01

    Climate change is among the most important global threats to biodiversity and mountain areas are supposed to be under especially high pressure. Although recent modelling studies suggest considerable future range contractions of montane species accompanied with increased extinction risk, data allowing to test actual population consequences of the observed climate changes and identifying traits associated to their adverse impacts are very scarce. To fill this knowledge gap, we estimated long-term population trends of montane birds from 1984 to 2011 in a central European mountain range, the Giant Mountains (Krkonoše), where significant warming occurred over this period. We then related the population trends to several species' traits related to the climate change effects. We found that the species breeding in various habitats at higher altitudes had more negative trends than species breeding at lower altitudes. We also found that the species moved upwards as a response to warming climate, and these altitudinal range shifts were associated with more positive population trends at lower altitudes than at higher altitudes. Moreover, long-distance migrants declined more than residents or species migrating for shorter distances. Taken together, these results indicate that the climate change, besides other possible environmental changes, already influences populations of montane birds with particularly adverse impacts on high-altitude species such as water pipit (Anthus spinoletta). It is evident that the alpine species, predicted to undergo serious climatically induced range contractions due to warming climate in the future, already started moving along this trajectory.

  9. The search for attitude-a hidden curriculum assessment from a central European perspective.

    Science.gov (United States)

    Ludwig, Birgit; Turk, Bela; Seitz, Tamara; Klaus, Isabella; Löffler-Stastka, Henriette

    2018-02-01

    Little is known about the development of the hidden curriculum in the medical education system. It refers to a conglomeration of implicit beliefs, attitudes and forms of conduct that are unwittingly transmitted from one generation of teaching physicians to the next. How can we describe this process, what are the potential positive or negative impacts, and last but not least, how can we measure it? Students of the Medical University of Vienna complete their clinical rotations in Vienna and in other accredited, mostly central European hospitals. They were subsequently invited to evaluate their rotations in an online questionnaire regarding dimensions, such as professionalism, teaching, integration and appreciation. In total, 133 students participated in this pilot study and the average response rate was 10.1%, similar to evaluations conducted prior to that. Although the evaluation results on average were positive, several experiences of deprecation and less professional conduct were present in each evaluated rotation. Giving the students the opportunity to reflect upon their experiences could be seen as an intervention and investigation at the same time. This survey serves as a precursor to a qualitative interview-based study, accompanying the implementation of case-based learning designed by collaborating residents and medical students. The findings of this pilot-study support the necessity of fostering a reflective capacity in the education of medical students, enabling them to speak up and live up to the expected professionalism despite shortcomings within the hidden curriculum.

  10. Central and Eastern European countries between the 16+1 platform and Chinese OBOR - One Belt, One Road - Initiative

    Directory of Open Access Journals (Sweden)

    George Cornel Dumitrescu

    2016-04-01

    Full Text Available This paper aims at analysing the projects and the initiatives of the Central and Eastern European countries that have been finalised, are in progress or will be developed in the near future with the help of the existing or future financial instruments specific to the 16+1 platform and the One Belt, One Road complex program. For our research we selected four countries, namely: Poland, Romania, Serbia and Hungary, the group being relevant from the perspective of the transportation corridors connected to the ”One Belt, One Road” initiative: (1 - Piraeus, Skopje, Belgrade, Budapest, Western Europe; (2 - Suez Canal, Constanta and then Danube, Western Europe, or through Moldova towards Ukraine and Poland; (3 – Constanta, through the Black Sea and Caspian Sea and then the corridors mentioned at the previous point. We based our analysis on the data provided by the National Bureau of Statistics of China, China-CEEC think-tank network and the literature in the field.

  11. Eustatic control on epicontinental basins: The example of the Stuttgart Formation in the Central European Basin (Middle Keuper, Late Triassic)

    Science.gov (United States)

    Franz, M.; Nowak, K.; Berner, U.; Heunisch, C.; Bandel, K.; Röhling, H.-G.; Wolfgramm, M.

    2014-11-01

    The deposition of the Stuttgart Formation ('Schilfsandstein'), commonly considered as a type-example of the Carnian Pluvial Event, was controlled by high frequent 4th order sequences that resulted in pre-, intra- and post-Schilfsandstein transgressions from Tethyan waters into the epicontinental Central European Basin (CEB). The pre-Schilfsandstein transgression flooded the CEB trough gates to the Southeast and resulted in a wide-spread inland sea that was characterised by increased biological productivity, predominantly oxic conditions and enabled the immigration of euryhaline marine fauna with plankton, ostracodes, fishes, bivalves and the gastropods Omphaloptychia suebica n. sp. and Settsassia stuttgartica n. sp. The rather short-term intra- and post-Schilfsandstein transgressions flooded the CEB from the Southwest and Southeast and established a shallow brackish inland sea that stretched up to North Germany. Both, the 4th and 3rd order sequences derived from the succession in the CEB correlate well with those derived from successions of Tethyan shelfs. Therefore pronounced circum-Tethyan eustatic cycles are evidenced and may have had considerable impact on prominent middle Carnian events: Reingraben turnover, Carnian Pluvial Event, Carnian Crisis and Mid Carnian Wet Intermezzo. The broad circum-Tethyan evidence of 106-year scale cycles suggests glacioeustatic sea-level changes even in the Triassic Greenhouse period.

  12. Population Trends of Central European Montane Birds Provide Evidence for Adverse Impacts of Climate Change on High-Altitude Species.

    Directory of Open Access Journals (Sweden)

    Jiří Flousek

    Full Text Available Climate change is among the most important global threats to biodiversity and mountain areas are supposed to be under especially high pressure. Although recent modelling studies suggest considerable future range contractions of montane species accompanied with increased extinction risk, data allowing to test actual population consequences of the observed climate changes and identifying traits associated to their adverse impacts are very scarce. To fill this knowledge gap, we estimated long-term population trends of montane birds from 1984 to 2011 in a central European mountain range, the Giant Mountains (Krkonoše, where significant warming occurred over this period. We then related the population trends to several species' traits related to the climate change effects. We found that the species breeding in various habitats at higher altitudes had more negative trends than species breeding at lower altitudes. We also found that the species moved upwards as a response to warming climate, and these altitudinal range shifts were associated with more positive population trends at lower altitudes than at higher altitudes. Moreover, long-distance migrants declined more than residents or species migrating for shorter distances. Taken together, these results indicate that the climate change, besides other possible environmental changes, already influences populations of montane birds with particularly adverse impacts on high-altitude species such as water pipit (Anthus spinoletta. It is evident that the alpine species, predicted to undergo serious climatically induced range contractions due to warming climate in the future, already started moving along this trajectory.

  13. The interrelationship of mycophagous small mammals and ectomycorrhizal fungi in primeval, disturbed and managed Central European mountainous forests.

    Science.gov (United States)

    Schickmann, Susanne; Urban, Alexander; Kräutler, Katharina; Nopp-Mayr, Ursula; Hackländer, Klaus

    2012-10-01

    Small forest dwelling mammals are considered to be major consumers and vectors of hypogeous ectomycorrhizal (ECM) fungi, which have lost the ability of active spore discharge. Fungal spore dispersal by mycophagy is deemed an important process involved in forest regeneration, resilience and vitality, primarily based on evidence from Australia and the Pacific Northwestern USA, but is poorly known for Central European mountainous forests thus far. Small mammal mycophagy was investigated by live trapping and microscopical analysis of faecal samples. All small mammal species recorded (Myodes glareolus, Microtus agrestis, Pitymys subterraneus, Apodemus spp., Glis glis, Sorex spp.) had ingested spores of ECM fungi, albeit in varying amounts. My. glareolus was found to be the most important vector of ECM fungal spores, both in quantity and diversity. Species of the genus Sorex seem to play a hitherto underestimated role as dispersers of fungal spores. Glis glis is likely to be an important vector owing to its large home range. Hypogeous ECM basidiomycetes accounted for most spores found in the faecal samples. The frequency of various genera of hypogeous ECM ascomycetes and ECM epigeous fungi was much lower. Comparison with null models indicated a non-random structure of the mycophagy network similar to other mutualistic bipartite networks. Mycophagy can be considered (1) to contribute to nutrition of small forest mammals, (2) to play a pivotal role for forest regeneration and functioning by providing mycorrhizal inoculum to tree seedlings and (3) to be vital for reproduction and diversity of the still poorly known hypogeous fungi.

  14. Alcohol Gel Ingestion Among Homeless Eastern and Central Europeans in London: Assessing the Effects on Cognitive Functioning and Psychological Health.

    Science.gov (United States)

    Soar, Kirstie; Papaioannou, Grammati; Dawkins, Lynne

    2016-08-23

    Intentional consumption of alcohol-based hand gels has been reported especially amongst non-UK national, alcohol dependent, homeless individuals in London. Whilst alcohol misuse is known to be associated with impaired cognitive functioning and mental health problems, the effects of additional ingestion of alcohol gel are unknown. To explore cognitive and psychological functioning in users who intentionally ingest alcohol gel compared with ethyl-alcohol only misusers and controls. Male, Central and Eastern European alcohol only misusers, (n = 14; mean age 39 years), alcohol gel users (n = 14; mean age 43 years) and controls (n = 12; mean age 31 years) were recruited from a London Homeless Service during 2013/14. Alcohol misusers, alcohol gel users and controls were compared on the Forwards and Backwards Digit Span Test; Block Design test; Retrospective and Prospective Memory Questionnaire (PRMQ) and the Hospital and Anxiety Depression Scale (HADS). Alcohol gel users performed significantly worse on the Block Design task (p alcohol only and control groups, and significantly worse on the digit span relative to controls (p = .01). Both alcohol misusing groups scored comparatively on digit span backwards (p alcohol gel group reported significantly higher levels of anxiety relative to controls (p = .02). Whilst there could be constitutional differences between alcohol misusers who additionally abuse alcohol gel, the findings suggest that alcohol gel ingestion may have a greater impact on psychological functioning than traditional alcohol misuse.

  15. Determinants of Capital Integration among Strategic Alliance Members in the Retail Sector: Evidence from Central and Southeast European Countries

    Directory of Open Access Journals (Sweden)

    Nikola Butigan

    2016-12-01

    Full Text Available Survival of firms requires continuous search for new and a restructuring of the existing competitive advantages. These can come either from firms’ internal factors or from cooperation with the environment. Cooperation among firms commonly takes place through the formation of strategic alliances. However, such form of cooperation presents only one stage in the integration of business entities. In the long run, strategic alliances can cease to exist or transform into a higher form of association based on capital integration. The objective of this paper is to explore the determinants of capital integration among strategic alliance member firms in retail sectors of several Central and Southeast European countries. Overall, the obtained findings suggest that business entities engage in integration with the aim of reaching hidden knowledge and skills, accessing distribution and supply channels, and developing new products and services. Integration is also driven with the aim of risk diversification and possible better market positioning, achieving the economies of scale, and improving organization and marketing. The opportunistic behavior of partners and limited managerial control represent its strongest barriers.

  16. Climate Change Influence on Agriculture and the Water-Energy-Food Nexus in Central and Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Camelia KANTOR

    2017-12-01

    Full Text Available The Water-Energy-Food (WEF Nexus concept has great potential for understanding a region’s vulnerability to climate change. This paper examines individual components that form the supporting pillars of the nexus in Central and Eastern European (CEE countries. An overview of specific CEE political environments that govern economic and environmental policies are examined to select several domains representing higher risks to society, environment and economies of selected countries, together with evaluation of extant interlinkages between climate change, agriculture and the WEF nexus. While a variety of studies quantify and analyze climate change impacts on water availability, crop yields, yield variability, or alternative energy needed to mitigate global warming effects, this paper shows there is no clear evidence of a nexus-based integration to help manage or mitigate extreme future climate change-related events in the region. The study provides a model for supporting WEF pillars and advances recommendations for consideration of the nexus approach in relation to climate adaptation.

  17. Changes in Central European Soil Moisture Availability and Atmospheric Circulation Patterns between 1875 and 2005 - Regional Climate Change in Progress?

    Science.gov (United States)

    Trnka, M.; Kysely, J.; Dubrovsky, M.; Mozny, M.; Hostynek, J.; Svoboda, M.; Hayes, M. J.; Zalud, Z.

    2007-12-01

    Relationships between the soil moisture availability and the atmospheric circulation in Central Europe were analyzed for the period 1881-2005. The analysis was based on the Hess-Brezowsky catalogue of circulation types (CTs), and a series of weekly self-calibrated Palmer Z-index (scZ-index) and Palmer Drought Severity Index (scPDSI) values at seven stations where high-quality daily data has recently become available. The results show that the large-scale droughts during spring months (MAM) were associated with east (E), south (S), and south- east (SE) circulation types, whereas during summer (JJA) and the whole vegetation season, i.e., April-September (VEG), the Central Europe high pressure systems (HM) and east (E) circulation types were conducive to drought. Statistically significant drying trends were noted at a majority of the stations, especially during MAM and JJA, over the whole period for which the scPDSI and scZ-index series were available (1875-2005). Although almost no statistically significant tendencies were found prior to 1940, a significant tendency towards more intense drought was present at all sites after this year. The largest drying trend was noted during the VEG and AMJ seasons. The overall drying trend might be associated with shifts in the frequency of CTs, especially during AMJ. Although the aggregate frequency of occurrence of drought-conducive CTs (i.e. E, S and HM) remained stable at approximately 30% up to the 1940s, a steady increase to the present 55% frequency is observed afterwards. Higher frequencies of S and HM types drove the observed increase of drought-conducive CTs at the expense of N types that are associated with wet conditions. The long-term shifts in the frequency of circulation types conducive to drought explain more than 50% of the long-term variations of both scZ-index and PDSI values over the territory of the Czech Republic, and they are likely to affect whole central European region as well. Acknowledgement: This study

  18. Quadrivalent HPV vaccination and risk of multiple sclerosis and other demyelinating diseases of the central nervous system.

    Science.gov (United States)

    Scheller, Nikolai Madrid; Svanström, Henrik; Pasternak, Björn; Arnheim-Dahlström, Lisen; Sundström, Karin; Fink, Katharina; Hviid, Anders

    2015-01-06

    Case reports have suggested a link between human papillomavirus (HPV) vaccination and development of multiple sclerosis and other demyelinating diseases. To investigate if quadrivalent HPV (qHPV) vaccination is associated with an increased risk of multiple sclerosis and other demyelinating diseases. Using nationwide registers we identified a cohort of all females aged 10 years to 44 years in Denmark and Sweden, followed up from 2006 to 2013, information on qHPV vaccination, and data on incident diagnoses of multiple sclerosis and other demyelinating diseases. The primary analysis used a cohort design including vaccinated and unvaccinated study participants. A secondary analysis used a self-controlled case-series design including only cases. Both analyses used a 2-year risk period following vaccination. Information on qHPV vaccination was obtained through the national vaccination and prescription registers. The primary outcomes were multiple sclerosis and a composite end point of other demyelinating diseases. Incidence rate ratios were estimated using Poisson regression, comparing rates of events in the 2-year risk periods following vaccination and in unvaccinated time periods. The study included 3,983,824 females, among whom 789,082 received a total of 1,927,581 qHPV vaccine doses. During follow-up, 4322 multiple sclerosis cases and 3300 cases of other demyelinating diseases were identified, of which 73 and 90, respectively, occurred within the risk period. In the cohort analysis, there was no increased risk of multiple sclerosis (crude incidence rates, 6.12 events/100,000 person-years [95% CI, 4.86-7.69] and 21.54 events/100,000 person-years [95% CI, 20.90-22.20] for the vaccinated and unvaccinated periods; adjusted rate ratio, 0.90 [95% CI, 0.70-1.15]) or other demyelinating diseases (crude incidence rates, 7.54 events/100,000 person-years [95% CI, 6.13-9.27] and 16.14 events/100,000 person-years [95% CI, 15.58-16.71]; adjusted rate ratio, 1.00 [95% CI, 0

  19. Influenza vaccination coverage rates in 5 European countries: a population-based cross-sectional analysis of the seasons 02/03, 03/04 and 04/05.

    Science.gov (United States)

    Müller, D; Szucs, T D

    2007-10-01

    Influenza continues to be a considerable health problem in Europe. Vaccination is the only preventive measure, reducing mortality and morbidity of influenza in all age groups The objective of this survey was to assess and compare the level of influenza vaccination coverage during three consecutive influenza seasons (02/03, 03/04, 04/05) in the five European countries United Kingdom, France, Italy, Germany and Spain, understand the driving forces and barriers to vaccination now and 3 years ago and determine vaccination intentions for the following winter. We conducted a random-sampling, telephone-based household survey among non-institutionalized individuals representative of the population aged 14 and over. The surveys used the same questionnaire for all three seasons. The data were subsequently pooled. Four target groups were determined for analysis: (1) persons aged 65 and over; (2) people working in the medical field; (3) persons suffering from chronic illness and (4) a group composed of persons aged 65 and over or working in the medical field or suffering from a chronic illness. The overall sample consisted of 28,021 people. The influenza vaccination coverage rate increased from 21.0% in season 02/03 to 23.6% in season 03/04 and then to 23.7% in season 04/05. The differences between the seasons are statistically significant (p = 0.01). The highest rate over all countries and seasons had Germany in season 04/05 with 26.5%, Spain had in season 02/03 with 19.3% the lowest rate totally. The coverage rate in the target group composed of person's aged 65 and over or working in the medical field or suffering from a chronic illness was 49.7% in season 02-04 and 50.0% in season 04/05. The driving forces and barriers to vaccination did not change over the years. The most frequent reasons for being vaccinated given by vaccines were: influenza, considered to be a serious illness which people wanted to avoid, having received advise from the family doctor or nurse to be

  20. Epidemiology of paediatric meningitis in central Côte d'Ivoire after the implementation of Haemophilus influenzae type b vaccination.

    Science.gov (United States)

    Touré, Fidèle S; Kouame, Samson; Tia, Honoré; Monemo, Pacôme; Cissé, Amadou; Diané, Bamourou; Becker, Sören L; Akoua-Koffi, Chantal

    2017-07-01

    Infectious meningitis accounts for enormous morbidity worldwide, but there is a paucity of data on its regional epidemiology in resource-constrained settings of sub-Saharan Africa. Here, we present a study on the aetiology of paediatric meningitis in central Côte d'Ivoire. Between June 2012 and December 2013, all cerebrospinal fluid (CSF) samples drawn at the University Teaching Hospital Bouaké were examined for the presence of bacterial and fungal pathogens. A causative agent was detected in 31 out of 833 CSF specimens (3.7%), with the most prevalent pathogens being Streptococcus pneumoniae (n=15) and Neisseria meningitidis (n=5). With the exception of neonates, these two bacteria were the most common agents in all age groups. Of note, only a single case of Haemophilus influenzae meningitis was detected. Hence, this study reports a considerable shift in the epidemiology of paediatric meningitis in central Côte d'Ivoire. Following the implementation of a nation-wide childhood vaccination programme against H. influenzae type b, this pathogen was much less frequently reported than in previous studies. The integration of specific vaccines against S. pneumoniae and N. meningitidis into the childhood vaccination programme in Côted'Ivoire holds promise to further reduce the burden due to infectious meningitis.

  1. Geophysical and petrological modeling of the lower crust and uppermost mantle in the Variscan and Proterozoic surroundings of the Trans-European Suture Zone in Central Europe

    Science.gov (United States)

    Puziewicz, Jacek; Polkowski, Marcin; Grad, Marek

    2017-04-01

    High-quality seismic data on the lower crust and uppermost lithospheric mantle in the Central European part of the Trans European Suture Zone, together with thermal and gravimetric data, enables the quantitative modeling of the rocks occurring in those parts of the lithosphere, including their mineral compositions and the chemical composition of individual minerals. The P3 seismic profile is located at the SW margin of the East European Craton. The lower crust is dominated by gabbronoritic intrusions (plagioclase An45Ab55, clinopyroxene Di80Hed20, orthopyroxene En74Fs26), and the uppermost mantle is harzburgitic (olivine and orthopyroxene Mg# 0.91). The lower crust and upper mantle of the P1 seismic profile belong to the Trans European Suture Zone, albeit the upper crust is of Variscan affinity. The P1 lower crust has gabbronoritic composition which is layered from plagioclase-rich compositions on the top to the orthopyroxene-rich ones at the bottom (plagioclase An45Ab55, clinopyroxene Di80Hed20, orthopyroxene En85Fs15), and is lithologically different Proterozoic and Variscan surroundings. The 100 × 200 km eclogite slice (garnet Alm48Gr25Py27, clinopyroxene Di51Hed10Jd39), with a thickness of 5-10 km, occurs in the uppermost mantle sampled by the P1 profile. The Niedźwiedź Massif is located at the NE margin of the Bohemian Massif, which shows an exposed Variscan basement. The lower crust beneath the Niedźwiedź Massif consists of gabbroic rock of variable proportions of plagioclase (An45Ab55) and clinopyroxene (Di80Hed20), whereas the uppermost mantle is supposedly spinel harzburgite (olivine, ortho- and clinopyroxene Mg# 0.90). Our models show that the lowermost crust and uppermost mantle of the East European Craton do not continue to the SW into the Trans European Suture Zone in its Central European section in Poland.

  2. Central Banking and the Crisis. A Comparison of the Federal Reserve and the European Central Bank Measures, and the ECB’s Changing Role in the EU Economic Governance System

    Directory of Open Access Journals (Sweden)

    Marcin Roman Czubala

    2016-06-01

    Full Text Available The European Central Bank (ECB has received a lot of criticism for its too little, too late performance to ease market pressures during the economic crisis. At the same time, the ECB and the Federal Reserve (FED have managed the new economic realities that have emerged in the international context differently. Despite the criticisms, the European Central Bank is the European Union institution that has assumed more control due to the new model of economic governance of the EU. Why did the Federal Reserve act so nimbly and quickly to calm the markets, while the ECB was so cautious in managing monetary policy? The aim of this paper is to perform a comparative analysis of the management of interest rates and other monetary policy measures undertaken by the Central Bank and the Federal Reserve during the economic crisis, as well as to understand the changes in the context of the ECB and the emergence of its authority within the European Union’s economic governance model since 2011. Thus, in order to carry out a scrupulous exposition, we will also limit the time frame of this study to the 2007-2014 period.

  3. The European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2).

    LENUS (Irish Health Repository)

    Valenciano, Marta

    2015-06-04

    In the first five I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe) influenza seasons vaccine effectiveness (VE) results were relatively homogenous among participating study sites. In 2013-2014, we undertook a multicentre case-control study based on sentinel practitioner surveillance networks in six European Union (EU) countries to measure 2013-2014 influenza VE against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. Influenza A(H3N2) and A(H1N1)pdm09 viruses co-circulated during the season.

  4. Long-term central and effector SHIV-specific memory T cell responses elicited after a single immunization with a novel lentivector DNA vaccine.

    Directory of Open Access Journals (Sweden)

    Géraldine Arrode-Brusés

    Full Text Available Prevention of HIV acquisition and replication requires long lasting and effective immunity. Given the state of HIV vaccine development, innovative vectors and immunization strategies are urgently needed to generate safe and efficacious HIV vaccines. Here, we developed a novel lentivirus-based DNA vector that does not integrate in the host genome and undergoes a single-cycle of replication. Viral proteins are constitutively expressed under the control of Tat-independent LTR promoter from goat lentivirus. We immunized six macaques once only with CAL-SHIV-IN- DNA using combined intramuscular and intradermal injections plus electroporation. Antigen-specific T cell responses were monitored for 47 weeks post-immunization (PI. PBMCs were assessed directly ex vivo or after 6 and 12 days of in vitro culture using antigenic and/or homeostatic proliferation. IFN-γ ELISPOT was used to measure immediate cytokine secretion from antigen specific effector cells and from memory precursors with high proliferative capacity (PHPC. The memory phenotype and functions (proliferation, cytokine expression, lytic content of specific T cells were tested using multiparametric FACS-based assays. All immunized macaques developed lasting peripheral CD8+ and CD4+ T cell responses mainly against Gag and Nef antigens. During the primary expansion phase, immediate effector cells as well as increasing numbers of proliferating cells with limited effector functions were detected which expressed markers of effector (EM and central (CM memory phenotypes. These responses contracted but then reemerged later in absence of antigen boost. Strong PHPC responses comprising vaccine-specific CM and EM T cells that readily expanded and acquired immediate effector functions were detected at 40/47 weeks PI. Altogether, our study demonstrated that a single immunization with a replication-limited DNA vaccine elicited persistent vaccine-specific CM and EM CD8+ and CD4+ T cells with immediate and

  5. Functional interpretation of representative soil spatial-temporal variability at the Central region of European territory of Russia

    Science.gov (United States)

    Vasenev, I.

    2012-04-01

    The essential spatial and temporal variability is mutual feature for most natural and man-changed soils at the Central region of European territory of Russia. The original spatial heterogeneity of forest and forest-steppe soils has been further complicated by a specific land-use history and different-direction soil successions due to environmental changes and human impacts. For demand-driven land-use planning and decision making the quantitative analysis, modeling and functional-ecological interpretation of representative soil cover patterns spatial variability is an important and challenging task that receives increasing attention from scientific society, private companies, governmental and environmental bodies. On basis of long-term different-scale soil mapping, key plot investigation, land quality and land-use evaluation, soil forming and degradation processes modeling, functional-ecological typology of the zonal set of elementary soil cover patterns (ESCP) has been done in representative natural and man transformed ecosystems of the forest, forest-steppe and steppe zones at the Central region of European territory of Russia (ETR). The validation and ranging of the limiting factors of functional quality and ecological state have been made for dominating and most dynamical components of ESCP regional-typological forms - with application of local GIS, traditional regression kriging and correlation tree models. Development, zonal-regional differentiation and verification of the basic set of criteria and algorithms for logically formalized distinguishing of the most "stable" & "hot" areas in soil cover patterns make it possible for quantitative assessment of dominating in them elementary landscape, soil-forming and degradation processes. The received data essentially expand known ranges of the soil forming processes (SFP) rate «in situ». In case of mature forests mutual for them the windthrow impacts and lateral processes make SFPs more active and complex both in

  6. The Central European Permian Basins; Rheological and structural controls on basin history and on inter-basin connectivity

    Science.gov (United States)

    Smit, Jeroen; Van Wees, Jan-Diederik; Cloetingh, Sierd

    2014-05-01

    We analyse the relative importance of the major crustal-scale fault zones and crustal architecture in controlling basin formation, deformation and the structural connections between basins. The North and South Permian Basins of Central Europe are usually defined by the extend of Rotliegend sedimentary and volcanic units and not by a common tectonic origin or development. Instead, the sub-basins that together form the Permian Basins are each controlled by different structural and/or rheological controls that are inherited from Early Paleozoïc and older geodynamic processes, they are even located in different crustal/lithospheric domains. The North Permian basin is located on Baltic crust that was thinned during Late Proterozoïc - Early Paleozoïc times. South of the Thor suture, the South Permian basin and its sub-basins are located on Avalonian crust (Southern North Sea and North German Basins) and on the transition of East European cratonic and Avalonian crust (Polish Through). The size of crustal domains and of the faults that govern basin formation requires a regional-scale to assess their impact on basins and sub-basins. In the case of the Permian Basins this encompasses East Avalonia and surroundings, roughly speaking the area north of the Variscan Rheïc suture, east of the Atlantic and southwest of the Teisseyre-Tornquist line. This approach sheds light on the effects of long lived differences in crustal fabric which are responsible for spatial heterogeneity in stress and strain magnitudes and zonations of fracturing, burial history and temperature history. The focus on understanding the geomechanical control of large crustal-scale fault structures will provide the constraints and geometrical and compositional input for local models of stress and strain. Considering their fundamentally different structural and rheological controls, the Permian (sub)basins have a remarkably common history of subsidence and inversion, suggesting a more or less continuous

  7. China’s Belt and Road Initiative Extension to Central and Eastern European Countries - Sixteen Nations, Five Summits, Many Challenges

    Directory of Open Access Journals (Sweden)

    Musabelliu Marsela

    2017-08-01

    Full Text Available The Belt and Road Initiative proclaimed by President Xi in 2013, a strategy developed by the Chinese government, is very important to China but is not confined to China. In order for the initiative to be successful it needs to be embraced by the countries on the terrestrial and maritime route indicated in the plan. In the late 1980s Deng Xiaoping proposed to integrate Socialism with Chinese Characteristics (Zhongguo Tese Shehui Zhuyi, into global capitalism and in the 1990s the Jiang Zemin leadership initiated the Going out policy (Zouchuqu Zhanlue, – the current Belt and Road Initiative is China’s continuation in implementing those policies into actual deeds. China’s accession to WTO in 2001 marked China’s full integration into the global economy and since then the People’s Republic of China (PRC has become the largest trading partner for more than 180 countries. The Xi-Li administration has been extremely proactive since it was established in 2012; from that year on, Chinese behavior in international affairs has gained an ever-growing role as a forger of economic and diplomatic ties between countries. The primary example of this behavior is the Belt and Road Initiative (BRI. As every serious foreign policy plan, the BRI is an accumulation of various other initiatives. For example, the cooperation mechanism “16+1”, with which the PRC has approached Central and Eastern European Countries (CEEC, can be integrated under the BRI. This paper analizes the “16+1” China-CEEC cooperation mechanism in the context of the bigger BRI initiative, and tries to comprehend the economic and political factors intertwined with its implementation.

  8. Near real time Forensic Disaster Analysis of the central European flood in June 2013 in Germany: Impact and management

    Science.gov (United States)

    Khazai, Bijan; Bessel, Tina; Möhrle, Stella; Dittrich, André; Schröter, Kai; Mühr, Bernhard; Elmer, Florian; Kunz-Plapp, Tina; Trieselmann, Werner; Kunz, Michael

    2014-05-01

    Within its current research activity on near real time Forensic Disaster Analysis (FDA), researchers from the Center for Disaster Management and Risk Reduction Technology (CEDIM) aim to identify major risk drivers and to understand the root causes of disaster and infer the implications for disaster mitigation. A key component of this activity is the development of rapid assessment tools which allow for a science based estimate of disaster impacts. The central European flood in June 2013 caused in Germany severe damage to buildings, infrastructure and agricultural lands and has had a great impact on people, transportation and the economy. In many areas thousands of people were evacuated. Electrical grid and local water supply utilities failed during the floods. Furthermore, traffic was disrupted in the interregional transportation network including federal highways and long distance railways. CEDIM analysed the impact and management of the flood event within an FDA activity. An analysis on the amount and spatial distribution of flood-related Twitter messages in Germany revealed a high interest in the flood in the social media. Furthermore, an analysis of the resilience of selected affected areas in Germany has been carried out to assess the impact of the flood on the district level. The resilience indicator is based on social, economic and institutional indicators which are supplemented with information on the number of people evacuated and transportation disruptions. Combined with the magnitude of the event, an index is calculated that allows for a rapid initial but preliminary estimate of the flood impact. Results show high resilience of the administrative districts along the Danube while heavy impacts are seen along the Mulde and Elbe.

  9. The Central European Flood in June 2013: Experiences from a Near-Real Time Disaster Analysis in Germany

    Science.gov (United States)

    Schröter, Kai; Khazai, Bijan; Mühr, Bernhard; Elmer, Florian; Bessel, Tina; Möhrle, Stella; Dittrich, André; Kreibich, Heidi; Fohringer, Joachim; Kunz-Plapp, Tina; Trieselmann, Werner; Kunz, Michael; Merz, Bruno

    2014-05-01

    The central European flood in June 2013 once again revealed that complete flood protection is not possible. Inundations caused severe damage to buildings, infrastructure and agricultural lands. Official estimates of total damage in Germany amount to approx. 8bn € which is lower than the damage caused by the August 2002 flood - the most expensive natural hazard experienced so far in Germany. Repeated and long lasting precipitation in combination with extremely adverse preconditions induced a large scale flood event. In Germany, particularly the catchment areas of the Danube and Elbe were affected. The June 2013 flood has been the most severe flood event in terms of spatial extent and magnitude of flood peaks in Germany during the last 60 years. Large scale inundation occurred as a consequence of levee breaches near Deggendorf (Danube), Groß Rosenau and Fischbeck (Elbe). The flood has had a great impact on people, transportation and the economy. In many areas more than 50,000 thousand people were evacuated. Electrical grid and local water supply utilities failed during the floods. Furthermore, traffic was disrupted in the interregional transportation network including federal highways and long distance railways. CEDIM analysed and assessed the flood event within its current research activity on near real time forensic disaster analysis (CEDIM FDA: www.cedim.de). This contribution gives an overview about the CEDIM FDA analyses' results. It describes the key hydro-meteorological factors that triggered this extraordinary event and draws comparisons to major flood events in August 2002 and July 1954. Further, it shows the outcomes of a rapid initial impact assessment on the district level using social, economic and institutional indicators which are supplemented with information on the number of people evacuated and transportation disruptions and combined with the magnitude of the event.

  10. Investigation of the climate-driven periodicity of shallow groundwater level fluctuations in a Central-Eastern European agricultural region

    Science.gov (United States)

    Garamhegyi, Tamás; Kovács, József; Pongrácz, Rita; Tanos, Péter; Hatvani, István Gábor

    2017-09-01

    The distribution and amount of groundwater, a crucial source of Earth's drinking and irrigation water, is changing due to climate-change effects. Therefore, it is important to understand groundwater behavior in extreme scenarios, e.g. drought. Shallow groundwater (SGW) level fluctuation under natural conditions displays periodic behavior, i.e. seasonal variation. Thus, the study aims to investigate (1) the periodic behavior of the SGW level time series of an agriculturally important and drought-sensitive region in Central-Eastern Europe - the Carpathian Basin, in the north-eastern part of the Great Hungarian Plain, and (2) its relationship to the European atmospheric pressure action centers. Data from 216 SGW wells were studied using wavelet spectrum analysis and wavelet coherence analyses for 1961-2010. Locally, a clear relationship exists between the absence of annual periodic behavior in the SGW level and the periodicity of droughts, as indicated by the self-calibrating Palmer Drought Severity Index and the Aridity Index. During the non-periodic intervals, significant drops in groundwater levels (average 0.5 m) were recorded in 89% of the wells. This result links the meteorological variables to the periodic behavior of SGW, and consequently, drought. On a regional scale, Mediterranean cyclones from the Gulf of Genoa (northwest Italy) were found to be a driving factor in the 8-yr periodic behavior of the SGW wells. The research documents an important link between SGW levels and local/regional climate variables or indices, thereby facilitating the necessary adaptation strategies on national and/or regional scales, as these must take into account the predictions of drought-related climatic conditions.

  11. Potential Population Genetic Consequences of Habitat Fragmentation in Central European Forest Trees and Associated Understorey Species—An Introductory Survey

    Directory of Open Access Journals (Sweden)

    Christoph Dobeš

    2017-02-01

    Full Text Available Habitat fragmentation threatens the maintenance of genetic diversity of affected populations. Assessment of the risks associated with habitat fragmentation is a big challenge as the change in population genetic diversity is a dynamic process, often acting over long time periods and depending on various characteristics pertaining to both species (life history traits and their populations (extrinsic characteristics. With this survey, we provide an introductory overview for persons who have to make or are interested in making predictions about the fate of forest-dwelling plant populations which have recently become fragmented and isolated from their main occurrences. We provide a concise introduction to the field of population genetics focusing on terms, processes and phenomena relevant to the maintenance of genetic diversity and vitality of plant populations. In particular the antagonistic effects of gene flow and random genetic drift are covered. A special chapter is devoted to Central European tree species (including the Carpathians which we treat in detail with reference to an extensive literature survey on population genetic studies assembled from the whole of Europe. We further provide an overview of the population biology of associated understorey species. We conclude with recommended steps to be taken for the evaluation of potential perils of habitat fragmentation or population thinning for the genetics of tree populations. The complexity of effects exerted by life history traits and extrinsic characteristics of populations suggest population genetic development is strongly situation dependent. Therefore, we recommend following a case-by-case approach ideally supported by computer simulations to predict future population genetic development of both trees and associated understorey species.

  12. Urban–Rural Contrasts in Central-Eastern European Cities Using a MODIS 4 Micron Time Series

    Directory of Open Access Journals (Sweden)

    Monika Tomaszewska

    2016-11-01

    Full Text Available A primary impact of urbanization on the local climate is evident in the phenomenon recognized as the Urban Heat Island (UHI effect. This urban thermal anomaly can increase the health risks of vulnerable populations to heat waves. The surface UHI results from emittance in the longer wavelengths of the thermal infrared; however, there are also urban anomalies that are detectable from radiance in the shorter wavelengths (3–5 micron of the Middle Infrared (MIR. Radiance in the MIR can penetrate urban haze which frequently obscures urban areas by scattering visible and near infrared radiation. We analyzed seasonal and spatial variations in MIR for three Central European cities from 2003 through 2012 using Moderate Resolution Imaging Spectrometer (MODIS band 23 (~4 micron to evaluate whether MIR radiance could be used to characterize heat anomalies associated with urban areas. We examined the seasonality of MIR radiance over urban areas and nearby croplands and found that the urban MIR anomalies varied due to time of year: cropland MIR could be larger than urban MIR when there was more exposed soil at planting and harvest times. Further, we compared monthly mean MIR with the Normalized Difference Vegetation Index (NDVI to analyze contrasts between urban and rural areas. We found that the seasonal dynamic range of the MIR could exceed that of the NDVI. We explored the linkage between meteorological data and MIR radiance and found a range of responses from strong to weak dependence of MIR radiance on maximum temperature and accumulated precipitation. Our results extend the understanding of the anomalous characteristics of urban areas within a rural matrix.

  13. Gender Role Attitudes among Higher Education Students in a Borderland Central-Eastern European Region called ‘Partium’

    Directory of Open Access Journals (Sweden)

    Hajnalka Fényes

    2014-06-01

    Full Text Available In this paper, we examine the attitudes towards gender roles among higher education students in a borderland Central-Eastern European region. We used the database of ‘The Impact of Tertiary Education on Regional Development’ project (N=602, 2010. We intend to determine what kind of attitudes towards gender roles the students identify themselves with, what affects these attitudes (gender, faculty type, social background of students, locality type, religiosity, and finally what kind of educational policy implications could be relevant concerning our findings. We have used cluster analysis and a logistic regression model, and formulated several hypotheses that were controlled by these methods. Our results show that there are a large number of students who belong to the more traditional attitude cluster in this region, but women more frequently identify themselves with modern gender roles than men do. The faculty-type effect has only been partly detected. We have found that with ‘male-dominated’ majors, both women and men identify themselves with more traditional attitudes and that with ‘female-dominated’ majors all students have more modern attitudes. The effect of social background is contradictory. Those whose parents had larger numbers of books had increased modern attitudes, but the factor ‘regular financial problems in the family’ also increased it. Our next result is that students who live in villages are not more traditional than others, because they live in cities during their studies. Our final result is that churchly religious students think more traditionally regarding gender roles than others do, but those who are religious in their own way do not.

  14. The behavior of osmium and other siderophile elements during impacts: Insights from the Ries impact structure and central European tektites

    Science.gov (United States)

    Ackerman, Lukáš; Magna, Tomáš; Žák, Karel; Skála, Roman; Jonášová, Šárka; Mizera, Jiří; Řanda, Zdeněk

    2017-08-01

    Impact processes are natural phenomena that contribute to a variety of physico-chemical mechanisms over an extreme range of shock pressures and temperatures, otherwise seldomly achieved in the Earth's crust through other processes. Under these extreme conditions with transient temperatures and pressures ≥3000 K and ≥100 GPa, followed by their rapid decrease, the behavior of elements has remained poorly understood. Distal glassy ejecta (tektites) were produced in early phases of contact between the Earth's surface and an impacting body. Here we provide evidence for a complex behavior of Os and other highly siderophile elements (HSE; Ir, Ru, Pt, Pd, and Re) during tektite production related to a hyper-velocity impact that formed the Ries structure in Germany. Instead of simple mixing between the surface materials, which are thought to form the major source of central European tektites (moldavites), and impactor matter, the patterns of HSE contents and 187Re/188Os - 187Os/188Os ratios in moldavites, target sediments and impact-related breccias (suevites) can be explained by several sequential and/or contemporary processes. These involve (i) evaporative loss of partially oxidized HSE from the overheated tektite melt, (ii) mixing of target-derived and impactor-derived HSE vapor (plasma) phases, and (iii) early (high-temperature) condensation of a part of the mixed vapor phase back to silicate melt droplets. An almost complete loss of terrestrial Os from the tektite melt and its replacement with extra-terrestrial Os are indicated by low 187Os/188Os ratios in tektites (0.69). This is paralleled by a co-variation between Os and Ni contents in tektites but not in suevites formed later in the impact process.

  15. Central European parasitic flatworms of the family Renicolidae Dollfus, 1939 (Trematoda: Plagiorchiida): molecular and comparative morphological analysis rejects the synonymization of Renicola pinguis complex suggested by Odening.

    Science.gov (United States)

    Heneberg, Petr; Sitko, Jiljí; Bizos, Jiří; Horne, Elizabeth C

    2016-10-01

    The Renicolidae are digenean parasites of piscivorous and molluscivorous birds. Although they exhibit few morphological autapomorphies and are highly variable, the numerous suggested re-classifications within the family have never been supported by any molecular analyses. We address the possible synonymization of species within the Renicola pinguis complex suggested previously by Odening. We provide and analyse sequences of two nuclear (ITS2, 28S rDNA) and two mitochondrial (CO1, ND1) DNA loci of central European species of the Renicolidae, namely Renicola lari, Renicola pinguis and Renicola sternae sp. n., and we also provide first sequences of Renicola sloanei. The combined molecular and comparative morphological analysis confirms the previously questioned validity of the three Renicola spp. of highly similar morphology, which display strict niche separation in terms of host specificity and selectivity. We identify two previously unreported clades within the genus Renicola; however, only one of them is supported by the analysis of adult worms. We also provide comparative measurements of the three examined closely related central European renicolids, and describe the newly proposed tern-specialized species Renicola sternae sp. n., which was previously repeatedly misidentified as Renicola paraquinta. Based on the extensive dataset collected in 1962-2015, we update the host spectrum of Renicolidae parasitizing central European birds (Renicola bretensis, R. lari, Renicola mediovitellata, R. pinguis, Renicola secunda and R. sternae sp. n.) and discuss their host-specific prevalence and intensity of infections.

  16. In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13

    DEFF Research Database (Denmark)

    Hungerford, Daniel; Vivancos, Roberto; Read, Jonathan M

    2016-01-01

    distribution and age distribution of rotavirus gastroenteritis (RVGE) cases in and out of peak season in 12 countries which were yet to implement routine rotavirus vaccination. In multinomial multivariate logistic regression, adjusting for year, country and age, the odds of infection caused by genotype......M-OR = 2.53; 95% CI: 1.67-3.82). This study provides further understanding of the rotavirus ecology before vaccine introduction, which will help interpret epidemiological changes in countries introducing or expanding rotavirus vaccination programmes.......The EuroRotaNet surveillance network has conducted rotavirus genotype surveillance since 2007 in 16 European countries. Using epidemiological and microbiological data from 39,786 genotyped rotavirus-positive specimens collected between September 2007 and August 2013, we assessed genotype...

  17. GLOBAL FINANCIAL CRISIS AND UNIT-LINKED INSURANCE MARKETS EFFICIENCY: EMPIRICAL EVIDENCE FROM CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Botoş Horia Mircea

    2012-12-01

    Full Text Available This paper empirically investigates the impact of the Global financial crisis on the efficiency of four Central and Eastern European emerging unit-linked insurance markets, applying the automatic variance ratio (AVR test of Kim (2009 and variance ratio tests using ranks and signs by Wright (2000 for entire, pre-crisis and crisis periods. This study contributes to the existing literature on efficient market hypothesis with several distinct features: it provides a systematic review of the weak-form market efficiency literature that examines return predictability of the daily ING unit-linked funds prices; also the article aims at monitoring any improvement in the degree of efficiency in time and also examines the relative efficiency of unit-linked insurance markets in pre-crisis and crisis periods. Unit linked insurance are life insurance policies with investment component. In the literature there are few studies investigating the effects of a financial crisis on the potential of predictability and implicitly on the degree of efficiency of financial markets. The occurrence of a market crash or financial crisis is a possible contributing factor of market inefficiency. Most of the studies are focused on the Asian crisis in 1997: Holden et al. (2005 examined the weak-form efficiency of eight emerging Asian stock markets using VR tests before, during and after the Asian crisis; Kim and Shamsuddin (2008 used three different types of multiple VR tests for nine Asian stock markets; the findings reported by Lim et al. (2008 are consistent with those reported by Cheong et al. (2007, in which the highest inefficiency occurs during the crisis period. Todea and Lazar (2010 investigated the effects of the Global crisis on the relative efficiency of ten CEE stock markets, using Generalized Spectral test of Escanciano and Velasco (2006. Wright (2000 proposes the alternative non-parametric variance ratio tests using ranks and signs of return and demonstrates that

  18. Adoption of in-vessel retention concept for VVER-440/V213 reactors in Central European Countries

    Energy Technology Data Exchange (ETDEWEB)

    Matejovic, Peter, E-mail: peter.matejovic@ivstt.sk [Inzinierska Vypoctova Spolocnost (IVS), Jana Holleho 5, 91701 Trnava (Slovakia); Barnak, Miroslav; Bachraty, Milan; Vranka, Lubomir [Inzinierska Vypoctova Spolocnost (IVS), Jana Holleho 5, 91701 Trnava (Slovakia); Berky, Robert [Integrita a Bezpecnost Ocelovych Konstrukcii, Rybnicna 40, 831 07 Bratislava (Slovakia)

    2017-04-01

    Highlights: • Design of in-vessel retention concept for VVER-440/V213 reactors. • Thermal loads acting on the inner reactor surface. • Structural response of reactor pressure vessel. • External reactor vessel cooling. - Abstract: An in-vessel retention (IVR) concept was proposed for standard VVER-440/V213 reactors equipped with confinement made of reinforced concrete and bubbler condenser pressure suppression system. This IVR concept is based on simple modifications of existing plant technology and thus it was attractive for plant operators in Central European Countries. Contrary to the solution that was adopted before at Loviisa NPP in Finland (two units of VVER-440/V213 reactor with steel confinement equipped with ice condenser), the coolant access to the reactor pressure vessel from flooded cavity is enabled via closable hole installed in the centre of thermal shield of the reactor lower head instead of lowering this massive structure in the case of severe accident. As a consequence, the crucial point of this IVR concept is narrow gap between torispherical lower head and thermal and biological shield. Here the highest thermal flux is expected in the case of severe accident. Thus, realistic estimation of thermal load and corresponding deformations of reactor wall and their impact on gap width for coolant flow are of primarily importance. In this contribution the attention is paid especially to the analytical support with emphasis to the following points: 1) {sup ∗}Estimation of thermal loads acting on the inner reactor surface; 2) {sup ∗}Estimation of structural response of reactor pressure vessel (RPV) with emphasis on the deformation of outer reactor surface and its impact on the annular gap between RPV wall and thermal/biological shield; 3) {sup ∗}Analysis of external reactor vessel cooling. For this purpose the ASTEC code was used for performing analysis of core degradation scenarios, the ANSYS code for structural analysis of reactor vessel

  19. DNA Vaccines

    Indian Academy of Sciences (India)

    research interests include: eukaryotic gene expres- sion and infectious diseases. Keywords. DNA vaccine, immune response, antibodies, infectious diseases. GENERAL I ... T -cells: Lymphocytes that differentiate primarily in the thymus and are central to the control and ... enhance DNA delivery into skeletal muscle.

  20. TRENDS REGARDING THE EVOLUTION OF THE ROMANIAN BANKING SYSTEM IN RELATION TO THE ONES BELONGING TO CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    DAVID DELIA

    2014-08-01

    Full Text Available This paper aims at highlighting the aspects concerning the impact suffered by the Central and Eastern European banking systems since the onset of the financial global crisis. The focus of the paper is on the position of the Romanian banking system in relation to the Central and Eastern European countries, mainly those countries which were former members of the Communist bloc, in terms of both the prudential and banking profitability indicators. Hence, a comparative case study has been conducted, at a macroeconomic level, regarding the evolution stage of the Romanian banking system in the context of the financial crisis, based on several representative banking systems in Central and Eastern Europe such as Czech Republic, Hungary, Poland and Russia. The conclusion from these studies is that in Romania, the banking system has made significant progress over the transition to a market economy, as the Romanian banks have been embracing banking strategies intended to improve performance. However, there are still steps necessary to be taken in order to catch up with the most representative banks in Central and Eastern Europe in terms of their level of development and performance.

  1. HPV vaccine

    Science.gov (United States)

    Vaccine - HPV; Immunization - HPV; Gardasil; HPV2; HPV4; Vaccine to prevent cervical cancer; Genital warts - HPV vaccine; Cervical dysplasia - HPV vaccine; Cervical cancer - HPV vaccine; Cancer of the cervix - HPV vaccine; Abnormal ...

  2. Polyfunctional cytokine production by central memory T cells from cattle in response to Mycobacterium bovis infection and BCG vaccination

    Science.gov (United States)

    Polyfunctional T cells simultaneously produce IFN-gamma, IL-2 and TNF-alpha and play relevant roles in several chronic infections, including TB. Mycobacterium bovis infection of cattle elicits ex vivo polyfunctional T cell responses. Vaccine-elicited IFN-gamma Tcm (CD4 plus CD45RO plus CCR7 plus) re...

  3. Hepatitis B virus markers among teenagers in the Araguaia region, Central Brazil: assessment of prevalence and vaccination coverage.

    Science.gov (United States)

    Melo, Laura Valdiane Luz; da Silva, Marcondes Alves Barbosa; Calçada, Cristiane de Oliveira Rodrigues; Cavalcante, Silvia Raquel Brandão; Souto, Francisco José Dutra

    2011-07-18

    The Brazilian hepatitis B (HBV) vaccination program for neonates was implemented in 1998 and broadened to include young people up to 20 years of age in 2001. However, HBV coverage of teenagers has not been systematically assessed in Brazil. A cross-sectional study was performed to estimate the magnitude of HBV infection and vaccine coverage among adolescent students regularly enrolled in the public schools of Barra do Garças, a city located in the state of Mato Grosso, Brazil. A representative sample was randomly obtained and participants were interviewed and had blood samples collected to test for HBV markers. The sample was composed of 576 subjects, 51% of which were females. The average age was 15, with the group ranging from 12 to 20 years of age. There were 29 anti-HBc reactive participants (5.0%). Four out of 29 were HBsAg positive (0.7%). Anti-HBs alone (vaccinated profile) showed in 323 (56.1%) students and 224 (38.9%) were negative for all HBV markers. Increasing age was associated with HBV exposure in a χ(2) for trend analysis (p=0.004). The prevalence of anti-HBs alone decreased as the subjects' age increased. Multivariate analysis showed independent association between HBV infection and the start of sexual activity. Another associated variable was the fact that the some students were enrolled in two low-income neighborhood schools. Our findings classify this area as low endemic for HBV and suggest that there is a progressive decrease in the spread of HBV in the region due to the introduction of universal vaccination of neonates. Approximately half of the adolescents 15 years or older were not immunized, which raises a concern in terms of the need to increase the vaccination rate for this segment of the population. Published by Elsevier Ltd.

  4. THE ANALYTICAL INSIGHT INTO CUSTOMER PERCEPTION OF QUALITY DETERMINANTS OF THE E-COMMERCE MODEL BUSINESS-TO-CONSUMER SUBJECTS IN THE CENTRAL EUROPEAN COUNTRIES

    OpenAIRE

    Radovan Bačík; Zsuzsanna Katalin Szabo; Richard Fedorko

    2014-01-01

    Purpose: The aim of the paper is to describe the specific aspects of the e-commerce model business-to-consumer as a constantly developing field of an economic life in the Central European countries according to their customers. The current state of e-business and business-to-consumer e-commerce issue was identified by the research in the Czech Republic, Hungary, Poland and Slovakia.Methodology/Approach: For the purposes of collecting primary data the crucial factor for the selection of e-shop...

  5. Contributions to the phytocoenological study of pure european beech forests in Oraştie river basin (central-western Romania)

    OpenAIRE

    Petru BURESCU; Valeriu Ioan VINŢAN

    2012-01-01

    În the current paper we present a phytocoenologic study of the phytocoenoses of the association Festuco drymejaeFagetum Morariu et al. 1968 (Syn.: Fagetum sylvaticae transylvaticum facies with Festuca drymeja I. Pop et al. 1974), found in the pure European beech forests of the Orăştie river basin, lying in the central-western part of Romania. The characterisation of the association under analysis as well as the presentation of the synthetic table have been done byselecting the most representa...

  6. THE INFLUENCE OF THE SIZE OF THE ECONOMY AND EUROPEAN INTEGRATION ON FOREIGN DIRECT INVESTMENTS IN THE CENTRAL, SOUTHEASTERN AND EASTERN EUROPEAN STATES 1994-2013

    Directory of Open Access Journals (Sweden)

    Petar Kurecic

    2016-03-01

    Full Text Available The paper studies the interdependence of the economy size and foreign direct investments (FDI in the transitional economies of Central, Southeastern and Eastern Europe. In the global capitalist economy, foreign direct investments (FDI represent one of the key determinants of economic growth. Among some transitional economies, in the last 20 years, FDI represented one of factors that increased the economic growth, and in other transitional economies, the influence of FDI was minor or even negligible. In the literature devoted to the influence of FDI on economies, the research about the determinants of geographical pattern of FDI distribution usually focuses on the factors that determine why some states manage to draw FDI in higher levels than some other states. Our research focused on the transitional economies of Central, Southeastern and Eastern Europe, which were for the most part of the last 20 years net receivers of the FDI. Only a couple of these countries in the years of the current economic crisis have experienced FDI net outflow. Among the states studied, we have equally studied the EU members, as well as the non-EU members. We have tried to find similarities and differences between these two groups of states in order to determine the influence of EU membership on FDI per capita and how it correlates with the size of the state’s economy. We have also tried to answer the question of how much the GDP growth rate correlates to the FDI net inflow share in GDP for EU and non-EU members. The methodology is based on the statistical correlation between FDI in current US dollars and GDP per capita in current US dollars (World Bank data for each represented state, through the surveyed period from 1994 until 2013. The statistical correlation matrix (Pearson method determined whether any correlation between the average GDP growth rate (chain index and the average share of FDI in GDP per each state exists for each state surveyed.

  7. Current and past smoking patterns in a Central European urban population: a cross-sectional study in a high-burden country

    Directory of Open Access Journals (Sweden)

    Narine K. Movsisyan

    2016-07-01

    Full Text Available Abstract Background Many studies have examined the socioeconomic variations in smoking and quitting rates across the European region; however, data from Central and East European countries, where the tobacco burden is especially high, are sparse. This study aimed to assess the patterns in current and past smoking prevalence based on cross-sectional data from a Central European urban population sample. Methods Data from 2160 respondents aged 25–64 years in Brno, Czech Republic were collected in 2013–2014 using the Czech post-MONICA survey questionnaire to assess the prevalence of cardiovascular risk factors, including smoking status. The age- and sex-stratified randomized sample was drawn using health insurance registries. Descriptive statistics and quit ratios were calculated, and chi-square and multivariate logistic analyses conducted to examine relationships between current and past smoking and demographic (age, gender, marital status and socioeconomic variables (education, income, occupation. Results The prevalence of current and past smoking was 23.6 and 31.3 % among men and 20.5 and 23.2 % among women, respectively. Education reliably predicted smoking and quitting rates in both genders. Among men, being unemployed was associated with greater odds of smoking (OR 3.6; 1.6–8.1 and lower likelihood of quitting (OR 0.2: 0.1–0.6; the likelihood of quitting also increased with age (OR 1.8; 1.2–2.8. Among women, marital status (being married decreased the odds of current smoking (OR 0.6; 0.4–0.9 and increased the odds of quitting (OR 2.2; 1.2–3.9. Quit ratios were the lowest in the youngest age group (25–34 years where quitting was more strongly associated with middle income (OR 2.7; 95 % CI 1.2–5.9 than with higher education (OR 2.9; 95 % CI 0.9–8.2. Conclusions Interventions to increase cessation rates and reduce smoking prevalence need to be gender-specific and carefully tailored to the needs of the disadvantaged groups

  8. The prediction role of indexes of circulating adipokines for common anthropometric and nutritional characteristics of obesity in the obese Central European population.

    Science.gov (United States)

    Bienertová-Vašků, Julie; Novák, Jan; Zlámal, Filip; Forejt, Martin; Havlenová, Soňa; Jackowská, Aneta; Tomandl, Josef; Tomandlová, Marie; Šplíchal, Zbyněk; Vašků, Anna

    2014-04-01

    This study was designed to investigate the relationship between 8 selected adipokines (leptin, leptin receptor, adiponectin, agouti-related peptide, omentin, visfatin, adipsin and resistin), dietary composition and anthropometric parameters found in the Central European obese population. A total of 65 unrelated obese Central European Caucasian individuals were recruited for the study. Phenotypic measurements included weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness. Participants completed standardized self-reported 7-day food records. Plasma levels of leptin, leptin receptor, adiponectin, agouti-related peptide (AgRP), resistin, adipsin, omentin and visfatin were examined using ELISA. Multiple associations (weight, height, percentage of body fat, waist circumference, hip circumference, WHR and sum of skinfold thickness) with the circulation levels of the investigated adipokines were identified. Leptin-Leptin receptor (L-LR) levels were found to correlate with total energy intake and macronutrients while adipsin was found to strongly correlate with multiple adipokines. Furthermore, the L-LR index was found to constitute a more accurate description of the relationship between BMI and body weight than individual measurements and the Ag-LR index was found to strongly correlate with both anthropometric and dietary characteristics. Following confirmation on larger population samples and on samples of different ethnicities, the reported adipokine indexes could become a useful tool for estimating nutritional status and predicting the body composition of specific patient groups. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Increased TNF-alpha/IFN-gamma/IL-2 and decreased TNF-alpha/IFN-gamma production by central memory T cells are associated with protective responses against bovine tuberculosis following BCG vaccination

    Science.gov (United States)

    Central memory T cells (Tcm’s) and polyfunctional CD4 T responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses by ...

  10. An improbable partnership: Spanish and Kazakh efforts to bring Central Asia to the fore of European politics

    Directory of Open Access Journals (Sweden)

    Licinia Simao

    2010-05-01

    Full Text Available El artículo discute sobre el potencial de la actual Presidencia española del Consejo de la UE y la Presidencia kazaja de la OSCE para coordinar esfuerzos en convertir a Asia Central en un área de interés más prominente para la política europea. Aporta un análisis de los intereses y de las principales áreas de interacción de las dos organizaciones en Asia Central y propone una reflexión sobre el impacto que tan improbable asociación podría tener en cambiar las perspectivas mutuas y en desarrollar una visión a largo plazo para la UE y la OSCE en Asia Central.

  11. Preparation for emergence of an Eastern European porcine reproductive and respiratory syndrome virus (PRRSV) strain in Western Europe: Immunization with modified live virus vaccines or a field strain confers partial protection.

    Science.gov (United States)

    Renson, P; Fablet, C; Le Dimna, M; Mahé, S; Touzain, F; Blanchard, Y; Paboeuf, F; Rose, N; Bourry, O

    2017-05-01

    The porcine reproductive and respiratory syndrome virus (PRRSV) causes huge economic losses for the swine industry worldwide. In the past several years, highly pathogenic strains that lead to even greater losses have emerged. For the Western European swine industry, one threat is the possible introduction of Eastern European PRRSV strains (example Lena genotype 1.3) which were shown to be more virulent than common Western resident strains under experimental conditions. To prepare for the possible emergence of this strain in Western Europe, we immunized piglets with a Western European PRRSV field strain (Finistere: Fini, genotype 1.1), a new genotype 1 commercial modified live virus (MLV) vaccine (MLV1) or a genotype 2 commercial MLV vaccine (MLV2) to evaluate and compare the level of protection that these strains conferred upon challenge with the Lena strain 4 weeks later. Results show that immunization with Fini, MLV1 or MLV2 strains shortened the Lena-induced hyperthermia. In the Fini group, a positive effect was also demonstrated in growth performance. The level of Lena viremia was reduced for all immunized groups (significantly so for Fini and MLV2). This reduction in Lena viremia was correlated with the level of Lena-specific IFNγ-secreting cells. In conclusion, we showed that a commercial MLV vaccine of genotype 1 or 2, as well as a field strain of genotype 1.1 may provide partial clinical and virological protection upon challenge with the Lena strain. The cross-protection induced by these immunizing strains was not related with the level of genetic similarity to the Lena strain. The slightly higher level of protection established with the field strain is attributed to a better cell-mediated immune response. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Mediterranean and central-eastern European countries host viruses of two different clades of plum pox virus strain M.

    Science.gov (United States)

    Dallot, Sylvie; Glasa, Miroslav; Jevremovic, Darko; Kamenova, Ivanka; Paunovic, Svetlana; Labonne, Gérard

    2011-03-01

    The genetic diversity of plum pox virus strain M (PPV-M) was assessed by analyzing 28 isolates collected in 8 European countries. Two genomic fragments spanning the (Cter)P3-6K1-(Nter)CI coding region as well as the full coat protein coding region were sequenced directly from PCR products. Phylogenetic analysis showed that the geographical origin of the collected isolates was clearly associated with two different PPV-M clades. Moreover, the pattern of substitutions in the CP gene shed light on the evolutionary relationships between PPV-M and the recombinant strains PPV-Rec and PPV-T.

  13. Temporal changes in the climate sensitivity of Norway spruce andEuropean beech along an elevation gradient in Central Europe

    Czech Academy of Sciences Publication Activity Database

    Kolář, Tomáš; Čermák, P.; Trnka, Miroslav; Žid, T.; Rybníček, Michal

    2017-01-01

    Roč. 2017, č. 239 (2017), s. 24-33 ISSN 0168-1923 R&D Projects: GA MŠk(CZ) LO1415; GA ČR GA13-04291S EU Projects: European Commission(XE) EHP-CZ02-0V-1-066-01-2014 Institutional support: RVO:67179843 Keywords : czech republic * drought * fagus sylvatica * picea abies * temperature * tree-ring width chronology Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 3.887, year: 2016

  14. The Central European Permian Basins; Rheological and structural controls on basin history and on inter-basin connectivity

    NARCIS (Netherlands)

    Smit, Jeroen; van Wees, Jan-Diederik; Cloetingh, Sierd

    2014-01-01

    We analyse the relative importance of the major crustal-scale fault zones and crustal architecture in controlling basin formation, deformation and the structural connections between basins. The North and South Permian Basins of Central Europe are usually defined by the extend of Rotliegend

  15. Distribution of central corneal thickness and its association with ocular parameters in a large central European cohort: the Gutenberg health study.

    Directory of Open Access Journals (Sweden)

    Esther M Hoffmann

    Full Text Available MAIN OBJECTIVE: To evaluate the distribution of central corneal thickness (CCT in a large German cohort and to analyse its relationship with intraocular pressure and further ocular factors. DESIGN: Population-based, prospective, cohort study. METHODS: The Gutenberg Health Study (GHS cohort included 4,698 eligible enrollees of 5,000 subjects (age range 35-74 years who participated in the survey from 2007 to 2008. All participants underwent an ophthalmological examination including slitlamp biomicroscopy, intraocular pressure measurement, central corneal thickness measurement, fundus examination, and were given a questionnaire regarding glaucoma history. Furthermore, all subjects underwent fundus photography and visual field testing using frequency doubling perimetry. RESULTS: Mean CCT was 557.3 ± 34.3 µm (male and 551.6±35.2 µm in female subjects (Mean CCT from right and left eyes. Younger male participants (35-44 years presented slightly thicker CCT than those older. We noted a significant CCT difference of 4 µm between right and left eyes, but a high correlation between eyes (Wilcoxon test for related samples: p<0.0001. Univariable linear regression stratified by gender showed that IOP was correlated with CCT (p<0.0001. A 10 µm increase in CCT led to an increase in IOP between 0.35-0.38 mm Hg, depending on the eye and gender. Multivariable linear regression analysis revealed correlations between gender, spherical equivalent (right eyes, and CCT (p<.0001 and p=0.03, respectively. CONCLUSIONS: We observed positive correlations between CCT and IOP and gender. CCT was not correlated with age, contact lens wear, positive family history for glaucoma, lens status, or iris colour.

  16. Barriers to access to opioid medicines: a review of national legislation and regulations of 11 central and eastern European countries.

    Science.gov (United States)

    Vranken, Marjolein J M; Lisman, John A; Mantel-Teeuwisse, Aukje K; Jünger, Saskia; Scholten, Willem; Radbruch, Lukas; Payne, Sheila; Schutjens, Marie-Hélène D B

    2016-01-01

    Control measures designed to prevent the misuse of opioid medicines can often unintentionally restrict legitimate medical use, leaving patients with cancer in pain. This study aimed to develop and validate an assessment instrument based on WHO policy guidelines to systematically identify legal and regulatory barriers to opioid access in 11 European countries (Bulgaria, Cyprus, Estonia, Greece, Hungary, Latvia, Lithuania, Serbia, Slovakia, Slovenia, and Turkey) as part of the Access to Opioid Medication in Europe project. Relevant legislation and regulations were independently assessed by three reviewers and potential barriers were identified within nine categories including prescribing, penalties, and others. Potential barriers were identified in all countries, ranging from 22 potential barriers (Cyprus) to 128 potential barriers (Lithuania). The total number of barriers in a single category varied from one (Slovenia, usage category) to 49 (Greece, prescribing category). Differences, such as prescription validity, varied within one category, ranging from 5 days (Hungary) to 13 weeks (Cyprus). The results of this Review should give rise to a national review and revision of provisions that impede access to opioids, disproportionate to their (intended) benefit in preventing misuse, in these 11 European countries. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Capacity development in food composition database management and nutritional research and education in Central and Eastern European, Middle Eastern and North African countries.

    Science.gov (United States)

    Gurinović, M; Witthöft, C M; Tepšić, J; Ranić, M; Hulshof, P J M; Hollman, P C; Porubska, J; Gohar, A; Debeljak-Martačić, J; Petrović-Oggiano, G; Novaković, R; Glibetić, M; Oshaug, A

    2010-11-01

    Capacity development (CD) in food and nutrition is much more than formal training and includes human resource development, and organisational, institutional and legal framework development with the aim of enhancing nutrition-relevant knowledge and skills to support infrastructural development. The goal of the European Food Information Resource (EuroFIR) Network of Excellence has been to develop and integrate food composition data throughout Europe. EuroFIR joined forces in CD with the United Nations (UN) University and UN System Standing Committee on Nutrition, the Network for Capacity Development in Nutrition in Central and Eastern Europe, the Central and Eastern European Countries Food Data Systems network and with the Middle East and North African Capacity Building Initiative. The aim of this paper is to discuss an inventory of the status of food composition databases (FCDBs) and the training needs of compilers in non-EuroFIR countries in Central and Eastern Europe (CEE) and in the Middle East and North Africa (MENA), and to present the CD achieved through EuroFIR and other network collaborations. Two online questionnaires were created addressing the FCDB status and specific training needs in countries of the targeted regions. Data were collected during 2006-2008 and then analysed. Subsequently, CD activities were organised. Contacts were established in 19 CEE and 7 MENA countries, of which several had national food composition tables, but no electronic versions. Education, training, workshops, networking and the sharing of experiences were uniformly requested. Subsequently, CD activities in EuroFIR were organised focussing on food composition courses, exchange visits, workshops and individual training for PhD students, junior scientists and other staff categories, as well as conferences linked to food composition research and food information. To facilitate CD activities, EuroFIR has signed a Memorandum of Understanding with the Czech Republic, Hungary

  18. Increased TNF-alpha/IFN-gamma/IL-2 and decreased TNF-alpha/IFN-gamma production by central memory T cells are associated with protective responses against bovine tuberculosis following BCG vaccination

    Directory of Open Access Journals (Sweden)

    Mayara Fernanda Maggioli

    2016-10-01

    Full Text Available Central memory T cells (Tcm and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB; however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses by CD4 T cell effector / memory populations from bacille Calmette Guerin (BCG vaccinated and non-vaccinated calves prior to and after aerosol challenge with virulent Mycobacterium bovis. Polyfunctional cytokine expression patterns in the response by Tcm, effector memory, and effector T cell subsets were similar between BCG-vaccinated and M. bovis-infected calves; only differing in magnitude (i.e., infected > vaccinated. BCG vaccination, however, did alter the kinetics of the ensuing response to virulent M. bovis infection. Early after challenge (three weeks post-infection, non-vaccinates had greater antigen-specific IFN-γ/TNF-α and lesser IFN-γ/TNF-α/IL-2 responses by Tcm cells than did vaccinated animals. Importantly, these differences were also associated with mycobacterial burden upon necropsy. Polyfunctional responses to ESAT-6:CFP10 (antigens not synthesized by BCG strains were detected in memory subsets, as well as in effector cells, as early as three weeks after challenge. These findings suggest that cell fate divergence may occur early after antigen priming in the response to bovine TB and that memory and effector T cells may expand concurrently during the initial phase of the immune response. In summary, robust IFN-γ/TNF-α response by Tcm cells is associated with greater mycobacterial burden while IFN-γ/TNF-α/IL-2 response by Tcm cells are indicative of a protective response to bovine TB.

  19. Installation and calibration of Kayzero-assisted NAA in three Central European countries via a Copernicus project

    Energy Technology Data Exchange (ETDEWEB)

    Corte, Frans de E-mail: frans.decorte@rug.ac.be; Sluijs, Robbert van; Simonits, A.; Kucera, Jan; Smodis, Borut; Byrne, Anthony R.; Wispelaere, Antoine de; Bossus, D.; Frana, Jaroslav; Horak, Z.; Jacimovic, Radojko

    2001-09-01

    An account is given of the installation and calibration of k{sub 0}-based NAA - assisted by the DSM Kayzero/Solcoi software package - at the KFKI-AEKI, Budapest, the NPI, Rez and the IJS, Ljubljana. Not only the calibration of the Ge-detectors and the irradiation facilities are discussed, but also other important topics such as gamma-spectrometric hard- and software, QC/QA of the IRMM-530 Al-Au flux monitor and the upgrade of the Kayzero/Solcoi code. The work was performed in the framework of a European Copernicus JRP, coordinated by the Laboratory of Analytical Chemistry, Gent, with DSM Research, Geleen, as the industrial partner.

  20. Veterinary and human vaccine evaluation methods

    Science.gov (United States)

    Knight-Jones, T. J. D.; Edmond, K.; Gubbins, S.; Paton, D. J.

    2014-01-01

    Despite the universal importance of vaccines, approaches to human and veterinary vaccine evaluation differ markedly. For human vaccines, vaccine efficacy is the proportion of vaccinated individuals protected by the vaccine against a defined outcome under ideal conditions, whereas for veterinary vaccines the term is used for a range of measures of vaccine protection. The evaluation of vaccine effectiveness, vaccine protection assessed under routine programme conditions, is largely limited to human vaccines. Challenge studies under controlled conditions and sero-conversion studies are widely used when evaluating veterinary vaccines, whereas human vaccines are generally evaluated in terms of protection against natural challenge assessed in trials or post-marketing observational studies. Although challenge studies provide a standardized platform on which to compare different vaccines, they do not capture the variation that occurs under field conditions. Field studies of vaccine effectiveness are needed to assess the performance of a vaccination programme. However, if vaccination is performed without central co-ordination, as is often the case for veterinary vaccines, evaluation will be limited. This paper reviews approaches to veterinary vaccine evaluation in comparison to evaluation methods used for human vaccines. Foot-and-mouth disease has been used to illustrate the veterinary approach. Recommendations are made for standardization of terminology and for rigorous evaluation of veterinary vaccines. PMID:24741009

  1. The triad of success in personalised medicine: pharmacogenomics, biotechnology and regulatory issues from a Central European perspective.

    Science.gov (United States)

    Mesko, Bertalan; Zahuczky, Gabor; Nagy, Laszlo

    2012-09-15

    The population of the world has recently passed the 7 billion milestone and as the cost of human genome sequencing is rapidly declining, sequence data of billions of people should be accessible much sooner than anyone would have predicted 10 years ago. This will form the basis of personalised medicine. However it is still not clear, even in principle, whether these data, combined with data of the expression of one's genome in various cells and tissues relevant to different diseases, could be used effectively in clinical medicine and healthcare, or in predicting responses to different therapies. Therefore this is an important issue which needs to be addressed before more resources are wasted on less than informative studies and surveys simply because technologies exist. As a typical example, we have selected and summarise here key studies from the biomedical literature that focus on gene expression profiling of the response to biologic therapies in peripheral blood and biopsy samples in autoimmune diseases such as rheumatoid arthritis, spondylarthropathy, inflammatory bowel diseases and psoriasis. We also present the state of the biotechnology market from a European perspective, discuss how spin-offs leverage the power of genomic technologies and describe how they might contribute to personalised medicine. As ethical, legal and social issues are essential in the area of genomics, we analysed these aspects and present here the European situation with a special focus on Hungary. We propose that the synergy of these three issues: pharmacogenomics, biotechnology and regulatory issues should be considered a triad necessary to succeed in personalised medicine. Copyright © 2012 Elsevier B.V. All rights reserved.

  2. Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells.

    Directory of Open Access Journals (Sweden)

    Joanne M Lumsden

    Full Text Available A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary challenge with infectious sporozoites in 40% of the 80 subjects enrolled in the study. The frequency of Plasmodium falciparum circumsporozoite protein (CSP-specific CD4(+ T cells was significantly higher in protected subjects as compared to non-protected subjects. Intrigued by these unique vaccine-related correlates of protection, in the present study we asked whether RTS,S also induced effector/effector memory (T(E/EM and/or central memory (T(CM CD4(+ T cells and whether one or both of these sub-populations is the primary source of cytokine production. We showed for the first time that PBMC from malaria-non-exposed RTS,S-immunized subjects contain both T(E/EM and T(CM cells that generate strong IL-2 responses following re-stimulation in vitro with CSP peptides. Moreover, both the frequencies and the total numbers of IL-2-producing CD4(+ T(E/EM cells and of CD4(+ T(CM cells from protected subjects were significantly higher than those from non-protected subjects. We also demonstrated for the first time that there is a strong association between the frequency of CSP peptide-reactive CD4(+ T cells producing IL-2 and the titers of CSP-specific antibodies in the same individual, suggesting that IL-2 may be acting as a growth factor for follicular Th cells and/or B cells. The frequencies of CSP peptide-reactive, TNF-α-producing CD4(+ T(E/EM cells and of CD4(+ T(E/EM cells secreting both IL-2 and TNF-α were also shown to be higher in protected vs. non-protected individuals. We have, therefore, demonstrated that in addition to TNF-α, IL-2 is also a significant contributing factor to RTS,S/AS vaccine induced immunity and that both T(E/EM and T(CM cells are major producers of IL-2.

  3. Does politics matter in the conduct of fiscal policy? Political determinants of the fiscal sustainability: Evidence from seven individual Central and Eastern European countries (CEEC

    Directory of Open Access Journals (Sweden)

    Redžepagić Srđan

    2007-01-01

    Full Text Available This paper aims at assessing the fiscal sustainability and its political determinants in seven Central and Eastern European Countries (CEEC, namely Estonia, Latvia, Lithuania, Poland, Slovenia, Slovakia and the Czech Republic. First, using the recent sustainability approach of Bohn (1998 based on fiscal reaction function, econometric findings using Ordinary Least Squares (OLS reveal a positive response of the primary surplus to changes in debt in several countries. In other words, fiscal policy is sustainable in Baltic countries, Slovenia and Slovakia, but not in Poland and in the Czech Republic. Second, by introducing political dummy variables, we test the electoral budget cycle and the partisan cycle theories. We find the presence of electoral and partisan cycle in Poland but not in the rest of our countries.

  4. Nuclear Power Plants in central-eastern european countries; Gli impianti nucleari nei paesi dell'Europa centro-orientale

    Energy Technology Data Exchange (ETDEWEB)

    Righetti, Benito [Ambasciata d' Italia a Budapest, Budapest (Uruguay); Grimaldi, Alessandro [Universita' di Macerata, Macerata (Italy)

    2006-06-15

    The nuclear energy sources in Central-Eastern European Countries consist of 26 nuclear power plants that can give a large contribution to the EU energy provisioning security, supplying a reliable electricity network distribution at competitive generation cost. However, most of these power plants belong to old generation plants and are obsolescent. More generally nuclear safety, back-end of the fuel cycle and decommissioning are object of a wide-ranging negotiation. [Italian] Nei paesi dell'Europa Centro-Orientale sono presenti 26 reattori nucleari che possono dare un ampio contributo alla sicurezza energetica della UE, fornendo una rete di distribuzione di energia elettrica affidabile e a costi competitivi. Tuttavia, la maggior parte di questi impianti e' di vecchia generazione ed ormai obsoleta. Piu' in generale la sicurezza nucleare, la destinazione finale del combustibile esausto e la dismissione degli impianti sono oggetto di complessa negoziazione.

  5. Elements of European Political Culture in the Central Asian National Outskirts of the Russian Empire: Perception Specifics of Foreign Cultural Innovations (late 19th – early 20th

    Directory of Open Access Journals (Sweden)

    Yuliya A. Lysenko

    2015-12-01

    Full Text Available The article considers the main results of political modernization in the Central Asian national outskirts of the Russian Empire taken place in the late 19th – early 20th centuries. The concept “Central Asian national outskirts” includes Stepnoy and Turkistan Governorate Generals, the two administrative-territorial entities founded in the 1860s as a result of a complete joining of the Kazakh camping grounds of the Junior, Middle and Elder zhuzhes; after the Kokand and Khivinsk khanates inhabited by nomads ( the Kirghiz, the Kara-Kalpaks as well as the settled population (the Uzbeks were conquered. The analysis of the sources and materials conducted by the authors asserts that the political modernization of the Central Asian national outskirts proposed by the Russian Empire was carried out in line with the fundamental characteristics of West European civilization and the basis of its political culture. Thus the system of local government was established and the democratic electoral system was introduced by means of expanding the voter’s base, with the region’s population participating in social and political life. The principles of bourgeois ideology based on such concepts as “equality”, “freedom”, “self-determination” were also formed. However, the political modernization of the Central Asian national outskirts should not be considered as complete. Up to 1917 the political sphere of the region’s population was characterized by the predominance of traditional mores, values and laws, whereas clan ideology, tribalism and Muslim ethno-consciousness were characteristic of the social sphere. All these factors affected the process of adapting to western political culture. The institutionalization of the new structures did not go along with the de-institutionalization of the traditional ones, and so resulted in the combination and coexistence of the traditional and modern structures.

  6. Clonality and spatial genetic structure in Populus x canescens and its sympatric backcross parent P. alba in a Central European hybrid zone.

    Science.gov (United States)

    van Loo, Marcela; Joseph, Jeffrey A; Heinze, Berthold; Fay, Mike F; Lexer, Christian

    2008-01-01

    Spatial genetic structure (SGS) holds the key to understanding the role of clonality in hybrid persistence, but multilocus SGS in hybrid zones has rarely been quantified. Here, the aim was to fill this gap for natural hybrids between two diploid, ecologically divergent European tree species with mixed sexual/asexual reproduction, Populus alba and P. tremula. Nuclear microsatellites were used to quantify clonality, SGS, and historical gene dispersal distances in up to 407 trees from an extensive Central European hybrid zone including three subpopulation replicates. The focus was on P. x canescens and its backcross parent P. alba, as these two genotypic classes co-occur and interact directly. Sexual recombination in both taxa was more prominent than previously thought, but P. x canescens hybrids tended to build larger clones extending over larger areas than P. alba. The 3.4 times stronger SGS in the P. x canescens genet population was best explained by a combination of interspecific gene flow, assortative mating, and increased clonality in hybrids. Clonality potentially contributes to the maintenance of hybrid zones of P. alba and P. tremula in time and space. Both clonality and SGS need to be taken into account explicitly when designing population genomics studies of locus-specific effects in hybrid zones.

  7. Development, features and application of DIET ASSESS & PLAN (DAP) software in supporting public health nutrition research in Central Eastern European Countries (CEEC).

    Science.gov (United States)

    Gurinović, Mirjana; Milešević, Jelena; Kadvan, Agnes; Nikolić, Marina; Zeković, Milica; Djekić-Ivanković, Marija; Dupouy, Eleonora; Finglas, Paul; Glibetić, Maria

    2018-01-01

    In order to meet growing public health nutrition challenges in Central Eastern European Countries (CEEC) and Balkan countries, development of a Research Infrastructure (RI) and availability of an effective nutrition surveillance system are a prerequisite. The building block of this RI is an innovative tool called DIET ASSESS & PLAN (DAP), which is a platform for standardized and harmonized food consumption collection, comprehensive dietary intake assessment and nutrition planning. Its unique structure enables application of national food composition databases (FCDBs) from the European food composition exchange platform (28 national FCDBs) developed by EuroFIR (http://www.eurofir.org/) and in addition allows communication with other tools. DAP is used for daily menu and/or long-term diet planning in diverse public sector settings, foods design/reformulation, food labelling, nutrient intake assessment and calculation of the dietary diversity indicator, Minimum Dietary Diversity-Women (MDD-W). As a validated tool in different national and international projects, DAP represents an important RI in public health nutrition epidemiology in the CEEC region. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. A comparison of methodological guides for creating microregional strategies of Central European rural areas. Case study: Czech Republic

    Directory of Open Access Journals (Sweden)

    Jakub Trojan

    2012-05-01

    Full Text Available This paper discusses the complementarity of methodological guides dealing with microregional development in Central Europe. As an example, the Czech Republic framework has been selected. This study compares seven common methodologies written in Czech, which the author has divided into three groups, namely manual-like methodologies, semi-scientific texts and hybrid texts dealing with other complementary aspects. The result is a comparison of methodologies, their usage and implications for the practices of regional development. The paper also includes a brief analysis of sustainable development elements incorporated into the methodological texts. The final part outlines links to the four-capital model of regional development.

  9. Soil compaction of various Central European forest soils caused by traffic of forestry machines with various chassis

    Directory of Open Access Journals (Sweden)

    Michal Allman

    2015-12-01

    Full Text Available Aim of study: The primary objective of this paper was to compare the effects of different types of forestry machine chassis on the compaction of the top layers of soil and to define the soil moisture content level, at which machine traffic results in maximum compaction.Area of study: Measurements were conducted in eight forest stands located in Slovakia and the Czech Republic. The soil types in the stands subjected to the study were luvisols, stagnosols, cambisols, and rendzinas.Material and Methods: The measurements were focused on tracked and wheeled (equipped with low pressure tyres cut-to-length machines, and skidders equipped with wide and standard tyres. The bulk density of soil was determined from soil samples extracted from the ruts, the centre of the skid trail, and the undisturbed stand. To determine soil moisture content, at which the soil is the most susceptible to compaction, the Proctor standard test was employed.Main results: The moisture content for maximal compaction fluctuated from 12% to 34.06%. Wheeled machines compacted the soil to 1.24 – 1.36 g.cm-3 (30.3 – 35.4 % compaction in dried state. Bulk density of soil in stands where tracked machine operated was lower, ranging from 1.02 to 1.06 g.cm-3 (25.3 % compaction.Research highlights: All wheeled machines caused the same amount of soil compaction in the ruts, despite differences in tyres, machine weight, etc. Maximum compaction caused by forestry machines occurred at minimal moisture contents, easily achievable in European climatic conditions.  Keywords: soil compaction; bulk density; soil moisture content limits; cut-to-length machines; skidders.

  10. Are healthcare workers' intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review

    National Research Council Canada - National Science Library

    Herzog, Raúl; Álvarez-Pasquin, María José; Díaz, Camino; Del Barrio, José Luis; Estrada, José Manuel; Gil, Ángel

    2013-01-01

    The Summit of Independent European Vaccination Experts (SIEVE) recommended in 2007 that efforts be made to improve healthcare workers' knowledge and beliefs about vaccines, and their attitudes towards them, to increase vaccination coverage...

  11. Evropejskaja ideja v Central'noj Evrope i Skandinavii kak chast' politiki bezopasnosti i mirnogo sosushhestvovanija v ramkah poslevoennogo planirovanija [The European idea in Central Europe and Scandinavia as a part of the security and peaceful co-existence policy in the framework of the postwar planning

    Directory of Open Access Journals (Sweden)

    Chernyshev Yevgeny

    2011-01-01

    Full Text Available This article is dedicated to the development of European unity in Central Europe and Scandinavia as a mechanism of collective security and intergovernmental cooperation development. The cultural and historical features of Central Europe and Scandinavia emphasize the need for a comparative study into the European idea. This article considers the tendencies and factors which affected the development of the European idea in the framework of the post-war planning. This research sets out to compare and identify similar or analogous features and elements of the theoretical bases of movements for European unity in Central and Northern Europe. The author comes to the conclusion about the correlation between the “Europe of regions” model and the European unity concept. The ideas of Scandinavian and Central European integration rested on national, cultural and historical connections of the neighbouring countries were expected to constitute such formations, which contradicted and were opposed to by the theoretical framework of Western European integration. On the other hand, regional integration implied that a federation or union of the neighbouring states could be considered a step towards a more universal organisation, which would not mean the isolation of Scandinavia and Central Europe from the rest of the world. The theoretical and practical significance of this work lies in the comparative approach to the analysis of the phenomena which have been considered individually in the framework of historiography. It is the major contribution of the article to the research on history of ideas and European diplomacy. Moreover, the subject of research is immediately connected to the problem of security in the Baltic region and the Soviet factor, as well as political stereotypes produced in this field. The author employed historical comparative and inductive types of the historical typological method.

  12. Vaccines (immunizations) - overview

    Science.gov (United States)

    Vaccinations; Immunizations; Immunize; Vaccine shots; Prevention - vaccine ... of the vaccine. VACCINE SCHEDULE The recommended vaccination (immunization) schedule is updated every 12 months by the ...

  13. THE USE OF CAPITAL AND CONDITION OF ECONOMICALLY WEAK FARMS IN THE SELECTED CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Aldona SKARŻYŃSKA

    2014-06-01

    Full Text Available This paper shows the economic situation of economically weak farms in 8 countries of Central and Eastern Europe(CEE in 2010. The data were obtained from the survey on EU farms carried out under the FADN system. The studyincluded countries in which economically weak farms were the dominant farm type (i.e. Bulgaria, Estonia, Hungary,Latvia, Lithuania, Poland, Romania and Slovakia. The aim of the study was to assess the economic performance ofthose farms and indicate advantages of the competing farm types. The analysis was performed in terms of totalfactor productivity, income levels, assets and debt level. The influence of CAP instruments on managementefficiency was also demonstrated. The study found a high diversity in terms of production potential as well asfinancial condition of farms in particular countries, whereas one point of correspondence between farms is theprevalence of fixed assets, i.e. an excessive assets-to-area ratio, and the dominance of own capital in financingthose assets. Romanian, Polish and Bulgarian farms are characterised by the highest efficiency of use of currentoutlays and, in turn, a lower cost of the production unit, which accounted for 66%, 86% and 87% of the outputvalue respectively. In Latvia, Estonia and Slovenia, the costs exceeded the output value by 6%, 7% and 23%respectively and, as a result, the income of those farms was generated exclusively due to subsidies.

  14. Molecular species identification of Central European ground beetles (Coleoptera: Carabidae using nuclear rDNA expansion segments and DNA barcodes

    Directory of Open Access Journals (Sweden)

    Raupach Michael J

    2010-09-01

    Full Text Available Abstract Background The identification of vast numbers of unknown organisms using DNA sequences becomes more and more important in ecological and biodiversity studies. In this context, a fragment of the mitochondrial cytochrome c oxidase I (COI gene has been proposed as standard DNA barcoding marker for the identification of organisms. Limitations of the COI barcoding approach can arise from its single-locus identification system, the effect of introgression events, incomplete lineage sorting, numts, heteroplasmy and maternal inheritance of intracellular endosymbionts. Consequently, the analysis of a supplementary nuclear marker system could be advantageous. Results We tested the effectiveness of the COI barcoding region and of three nuclear ribosomal expansion segments in discriminating ground beetles of Central Europe, a diverse and well-studied invertebrate taxon. As nuclear markers we determined the 18S rDNA: V4, 18S rDNA: V7 and 28S rDNA: D3 expansion segments for 344 specimens of 75 species. Seventy-three species (97% of the analysed species could be accurately identified using COI, while the combined approach of all three nuclear markers provided resolution among 71 (95% of the studied Carabidae. Conclusion Our results confirm that the analysed nuclear ribosomal expansion segments in combination constitute a valuable and efficient supplement for classical DNA barcoding to avoid potential pitfalls when only mitochondrial data are being used. We also demonstrate the high potential of COI barcodes for the identification of even closely related carabid species.

  15. Genetic and phenotypic variation in central and northern European populations of Aedes (Aedimorphus) vexans (Meigen, 1830) (Diptera, Culicidae).

    Science.gov (United States)

    Francuski, Ljubinka; Milankov, Vesna; Ludoški, Jasmina; Krtinić, Bosiljka; Lundström, Jan O; Kemenesi, Gábor; Ferenc, Jakab

    2016-06-01

    The floodwater mosquito Aedes vexans can be a massive nuisance in the flood plain areas of mainland Europe, and is the vector of Tahyna virus and a potential vector of Dirofilaria immitis. This epidemiologically important species forms three subspecies worldwide, of which Aedes vexans arabiensis has a wide distribution in Europe and Africa. We quantified the genetic and phenotypic variation in Ae. vexans arabiensis in populations from Sweden (northern Europe), Hungary, and Serbia (central Europe). A landscape genetics approach (FST , STRUCTURE, BAPS, GENELAND) revealed significant differentiation between northern and southern populations. Similar to genetic data, wing geometric morphometrics revealed two different clusters, one made by Swedish populations, while another included Hungarian and Serbian populations. Moreover, integrated genetic and morphometric data from the spatial analysis suggested groupings of populations into three clusters, one of which was from Swedish and Hungarian populations. Data on spatial analysis regarding an intermediate status of the Hungarian population was supported by observed Isolation-by-Distance patterns. Furthermore, a low proportion of interpopulation vs intrapopulation variance revealed by AMOVA and low-to-moderate FST values on a broader geographical scale indicate a continuous between-population exchange of individuals, including considerable gene flow on the regional scale, are likely to be responsible for the maintenance of the observed population similarity in Aе. vexans. We discussed data considering population structure in the light of vector control strategies of the mosquito from public health importance. © 2016 The Society for Vector Ecology.

  16. Vaccine hesitancy

    Science.gov (United States)

    Dubé, Eve; Laberge, Caroline; Guay, Maryse; Bramadat, Paul; Roy, Réal; Bettinger, Julie A.

    2013-01-01

    Despite being recognized as one of the most successful public health measures, vaccination is perceived as unsafe and unnecessary by a growing number of individuals. Lack of confidence in vaccines is now considered a threat to the success of vaccination programs. Vaccine hesitancy is believed to be responsible for decreasing vaccine coverage and an increasing risk of vaccine-preventable disease outbreaks and epidemics. This review provides an overview of the phenomenon of vaccine hesitancy. First, we will characterize vaccine hesitancy and suggest the possible causes of the apparent increase in vaccine hesitancy in the developed world. Then we will look at determinants of individual decision-making about vaccination. PMID:23584253

  17. Occurrence and stability of inorganic and organic arsenic species in wines, rice wines and beers from Central European market.

    Science.gov (United States)

    Huang, J-H; Hu, K-N; Ilgen, J; Ilgen, G

    2012-01-01

    We investigated in total 80 wine samples of different types and seven grape juice and 23 beer samples purchased from markets in Central Europe in order to understand the arsenic (As) speciation and help assess the potential As toxicity via intake of alcoholic beverages. Generally, total As concentrations in most samples investigated were below the drinking water limit 10 µg l(-1) published by the World Health Organization (WHO); ranging from 0.46 to 21.0 µg l(-1) As in red and white wines and from 0.75 to 13.4 µg l(-1) As in beers. In addition, concentrations of total As in rice wine and in rice beer were 0.63-6.07 and 3.69-8.23 µg l(-1) As, respectively. The total As concentrations in ice wine ranged from 7.94 to 18.8 µg l(-1) As, significantly higher than in white and red wine. Arsenite predominated as the As species in most of the wine samples, whereas arsenate was the dominant species in rice wine, beer and rice beer. Methyl As components were usually minor components in all wine and beer samples. Monomethylarsonic acid, dimethylarsinic acid and two additional unknown As species were frequently found in grape juice, late harvest and ice wine with higher sweetness. After air exposure, arsenite, arsenate, monomethylarsonic acid and dimethylarsinic acid were stable at 4°C for months, probably due to the acidic conditions of wine and beer samples. The presence of sulfite had little influence on As speciation in wine. Despite the predominance of more toxic arsenite and arsenate in wine and beer, the estimated weekly exposure to As (via consumption of beer, wine and rice wine) is low. The As intake per capita is 6.81 µg from beer, rice wine, estimated using the median of total As concentration multiplied by the average consumption per capita of the corresponding beverage.

  18. Life cycle assessment of post-consumer plastics production from waste electrical and electronic equipment (WEEE) treatment residues in a Central European plastics recycling plant

    Energy Technology Data Exchange (ETDEWEB)

    Wäger, Patrick A., E-mail: patrick.waeger@empa.ch; Hischier, Roland

    2015-10-01

    Plastics play an increasingly important role in reaching the recovery and recycling rates defined in the European WEEE Directive. In a recent study we have determined the life cycle environmental impacts of post-consumer plastics production from mixed, plastics-rich WEEE treatment residues in the Central European plant of a market-leading plastics recycler, both from the perspective of the customers delivering the residues and the customers buying the obtained post-consumer recycled plastics. The results of our life cycle assessments, which were extensively tested with sensitivity analyses, show that from both perspectives plastics recycling is clearly superior to the alternatives considered in this study (i.e. municipal solid waste incineration (MSWI) and virgin plastics production). For the three ReCiPe endpoint damage categories, incineration in an MSWI plant results in an impact exceeding that of the examined plastics recycling facility each by about a factor of 4, and the production of virgin plastics has an impact exceeding that of the post-consumer recycled (PCR) plastics production each by a factor of 6–10. On a midpoint indicator level the picture is more differentiated, showing that the environmental impacts of the recycling options are lower by 50% and more for almost all impact factors. While this provides the necessary evidence for the environmental benefits of plastics recycling compared to existing alternatives, it can, however, not be taken as conclusive evidence. To be conclusive, future research will have to address the fate of hazardous substances in the outputs of such recycling systems in more detail. - Highlights: • LCA of plastics production from plastics-rich WEEE treatment residues • Multiple stakeholder perspectives addressed via different research questions • Plastics production from WEEE treatment residues clearly superior to alternatives • Robust results as demonstrated by extensive sensitivity analyses.

  19. AN ASSESSMENT OF THE RELATIONSHIPS BETWEEN THE CULTURAL HERITAGE, TRAVEL n TOURISM, AND SUSTAINABLE DEVELOPMENT IN THE CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Dugulan Diana

    2012-07-01

    Full Text Available The cultural heritage, including, according to the UNESCO definition, the assembly of monuments, groups of buildings, and sites which are of outstanding universal value from the historical, aesthetic, ethnological or anthropological point of view, represents an important asset that can be engaged and capitalized in order to support the sustainable development. Meeting the needs of the present without compromising the ability of the future generations to meet their own needs in order to provide a better quality of life for everyone, now and for generations to come, has become a concern and, in the same time, a priority for all the stakeholders of the society. Turning to the best account of the cultural heritage also represents an important driver for the sustainable development of the travel and tourism industry, as the cultural sites, institutions, goods and services, appropriately capitalized, represent significant attractions for the international and domestic tourists. The integration of the principles of sustainable development in the current functioning of the travel and tourism industry led to the development and implementation of the concept of sustainable tourism. The paper explores in a distinctive manner the relationships between the cultural heritage and the travel and tourism industry, respectively the cultural heritage and the sustainable development based on a set of related statistical indicators, and the specific secondary data, expressing the extent of the cultural heritage, the development of the travel and tourism industry, and the attained level of sustainable development in ten Central and Eastern European countries, members of the European Union. There are two major research questions the paper aims to answer: (1 How significant is the relationship between the cultural heritage and the development of the travel and tourism industry? (2 Is there a noteworthy connection between the cultural heritage and the sustainable

  20. Budget impact analysis of biosimilar infliximab (CT-P13) for the treatment of rheumatoid arthritis in six Central and Eastern European countries.

    Science.gov (United States)

    Brodszky, Valentin; Baji, Petra; Balogh, Orsolya; Péntek, Márta

    2014-05-01

    The first biosimilar monoclonal antibody (infliximab, CT-P13) was registered by the European Medicines Agency in 2013 for the treatment of several inflammatory conditions including rheumatoid arthritis (RA). Biosimilar infliximab is first being marketed in the Central and Eastern European countries. This paper presents the estimated budget impact of the introduction of biosimilar infliximab in RA over a 3-year time period in six selected countries, namely Bulgaria, the Czech Republic, Hungary, Poland, Romania and Slovakia. A prevalence-based model was constructed for budget impact analysis. Two scenarios were compared to the reference scenario (RSc) where no biosimilar infliximab is available: biosimilar scenario 1 (BSc1), where interchanging the originator infliximab with biosimilar infliximab is disallowed, and only patients who start new biological therapy are allowed to use biosimilar infliximab; as well as biosimilar scenario 2 (BSc2), where interchanging the originator infliximab with biosimilar infliximab is allowed, and 80% of patients treated with originator infliximab are interchanged to biosimilar infliximab. Compared to the RSc, the net savings are estimated to be €15.3 or €20.8 M in BSc1 and BSc2, respectively, over the 3 years. If budget savings were spent on reimbursement of additional biosimilar infliximab treatment, approximately 1,200 or 1,800 more patients could be treated in the six countries within 3 years in the two biosimilar scenarios, respectively. The actual saving is most sensitive to the assumption of the acquisition cost of the biosimilar drug and to the initial number of patients treated with biological therapy. The study focused on one indication (RA) and demonstrated that the introduction of biosimilar infliximab can lead to substantial budget savings in health care budgets. Further savings are expected for other indications where biosimilar medicines are implemented.

  1. The Post-Socialist Transformation of Central and Eastern European Countries at the Turn of the Century: Regional Development and Economic Inequality

    Directory of Open Access Journals (Sweden)

    Askar Akayevich Akayev

    2016-09-01

    Full Text Available The evolution of the socio-economic systems is a non-linear process and it contains periods with smooth changes and subsequent periods of sharp jump transformation. The general design of new prospects opens at a stage of the birth of evolutionary processes, their forecasting requires the analysis of the historical prerequisites and risks, which are closely integrated to the change of moods in society. With the collapse of the Soviet Union, the newly independent states have passed the transformational and evolutional stage of development from the regional economy (they actually were the regions to the economy of the state; the Central and Eastern European countries have experienced a dramatic “drift” to the European Union. In the article, the results of almost 25 years’ transformation of these states are considered. New states, formed as a result of the collapse of the USSR, passed throughout three types of transformation. Firstly, it is the transformation at the ideological level. The transformation of the second type was purely economic. The third type can be characterized as the institutional (including structural and financial transformation. It is shown that one of the important reasons for the modest economic performance in the post-Soviet space is that newly independent states ignore and do not use in the practice the principles of regional policy and regional modernization. One of the important characteristic of the social and economic evolution of the countries of Eastern Europe after 1990 became the process of stratification and social differentiation of society with an insufficiently strong middle class and the polarization in income levels between the different regions. The increasing polarization in the income levels of the various regions acts as the dominating trend of the growing economic inequality

  2. Metabolic activity and behavior of the invasive amphipod Dikerogammarus villosus and two common Central European gammarid species (Gammarus fossarum, Gammarus roeselii): Low metabolic rates may favor the invader.

    Science.gov (United States)

    Becker, Jochen; Ortmann, Christian; Wetzel, Markus A; Koop, Jochen H E

    2016-01-01

    The Ponto-Caspian amphipod Dikerogammarus villosus is one of the most successful invaders in Central European rivers. Contrary to studies on its ecology, ecophysiological studies comparing the species' physiological traits are scarce. In this context, in particular the metabolic activity of the invasive species has rarely been considered and, moreover, the few existing studies on this species report strongly deviating results. The purpose of this study was to assess the metabolic activity and behavior of D. villosus and other common European amphipod species (Gammarus fossarum, Gammarus roeselii) in relation to temperatures covering the thermal regime of the invaded habitats. Based on direct calorimetric measurements of metabolic heat dissipation at three temperature levels (5°C, 15°C and 25°C), we found the routine metabolic rate of D. villosus to be significantly lower than that of the other studied gammarid species at the medium temperature level. The estimated resting metabolic rate indicated a similar trend. At 5°C and 25°C, both routine and resting metabolic rate did not differ between species. Compared to G. fossarum and G. roeselii, D. villosus exhibited lower locomotor activity at the low and medium temperatures (5°C and 15°C). In contrast, its locomotor activity increased at the high experimental temperature (25°C). G. fossarum and G. roeselii were apparently more active than D. villosus at all studied temperatures. We conclude that D. villosus has both physiological and behavioral adaptations that lead to a reduction in metabolic energy expenditure, which is assumed to be beneficial and might contribute to its invasive success. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Life cycle assessment of post-consumer plastics production from waste electrical and electronic equipment (WEEE) treatment residues in a Central European plastics recycling plant.

    Science.gov (United States)

    Wäger, Patrick A; Hischier, Roland

    2015-10-01

    Plastics play an increasingly important role in reaching the recovery and recycling rates defined in the European WEEE Directive. In a recent study we have determined the life cycle environmental impacts of post-consumer plastics production from mixed, plastics-rich WEEE treatment residues in the Central European plant of a market-leading plastics recycler, both from the perspective of the customers delivering the residues and the customers buying the obtained post-consumer recycled plastics. The results of our life cycle assessments, which were extensively tested with sensitivity analyses, show that from both perspectives plastics recycling is clearly superior to the alternatives considered in this study (i.e. municipal solid waste incineration (MSWI) and virgin plastics production). For the three ReCiPe endpoint damage categories, incineration in an MSWI plant results in an impact exceeding that of the examined plastics recycling facility each by about a factor of 4, and the production of virgin plastics has an impact exceeding that of the post-consumer recycled (PCR) plastics production each by a factor of 6-10. On a midpoint indicator level the picture is more differentiated, showing that the environmental impacts of the recycling options are lower by 50% and more for almost all impact factors. While this provides the necessary evidence for the environmental benefits of plastics recycling compared to existing alternatives, it can, however, not be taken as conclusive evidence. To be conclusive, future research will have to address the fate of hazardous substances in the outputs of such recycling systems in more detail. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. State-Sponsored Homophobia and the Denial of the Right of Assembly in Central and Eastern Europe : The "Boomerang" and the "Ricochet" between European Organizations and Civil Society to Uphold Human Rights

    NARCIS (Netherlands)

    Holzhacker, Ronald

    2013-01-01

    State-sponsored homophobia emerged in certain Central and Eastern European states in the past decade, with the denial of the right of assembly for gay pride marches. However, more recently there has been progress in the recognition of the fundamental democratic right of assembly. What accounts for

  5. Depletion, cryptic metasomatism, and modal metasomatism of central European lithospheric mantle: evidence from elemental and Li isotope compositions of spinel peridotite xenoliths, Kozákov volcano, Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Medaris Jr., L. G.; Ackerman, Lukáš; Jelínek, E.; Magna, T.

    2015-01-01

    Roč. 104, č. 8 (2015), s. 1925-1956 ISSN 1437-3254 Institutional support: RVO:67985831 Keywords : Central European lithospheric mantle * geochemistry * geothermometry * Li isotopes * spinel peridotite xenoliths Subject RIV: DD - Geochemistry Impact factor: 2.133, year: 2015

  6. Ecosystem Disturbances in Central European Spruce Forests: a Multi-proxy Integration of Dendroecology and Sedimentary Records

    Science.gov (United States)

    Clear, J.; Chiverrell, R. C.; Kunes, P.; Boyle, J.; Kuosmanen, N.; Carter, V.

    2016-12-01

    The montane Norway spruce (Picea abies) dominated forests of Central Europe are a niche environment; situated outside their natural boreal distribution they are vulnerable to both short term disturbances (e.g. floods, avalanches, fire, windstorm and pathogens) and longer-term environmental change (e.g. climate induced stress, snow regimes). Holocene sediment records from lakes in the High Tatra (Slovakia) and Bohemian (Czech) Mountains show repeated disturbances of the pristine Picea abies-dominated forests as sharp well defined minerogenic in-wash horizons that punctuate the accumulation of organic gyttja. These event horizons span a process continuum from lakes with restricted catchments and limited inflow (e.g. Prazilske Lake, Czech) to more catchment-process dominated lakes with large catchments (e.g. Popradske Lake, Slovakia). The events include complex responses to a global climatic downturn at 8.2ka, other cooler episodes 3.5, 1.6 and 0.5 ka, and to recent discrete wind-storms and pathogen outbreaks. We develop a typology for disturbance events using sediment geochemistry, particle size, mineral magnetism, charcoal and palaeoecology to assess likely drivers of disturbance. For the recent past integrating data from dendroecology and sediments is used to calibrate our longer-term perspective on forest dynamics. Tree-ring series from plots or forest stands are used alongside lake and forest hollow sediments to explore the local, regional and biogeographical scale of forest disturbances. Dendroecological data showing tree-ring gap recruitment and post-suppression growth release highlight frequent disturbance events focused on tree or forest stand spatial scales, but are patchy in terms of their reoccurrence. However they highlight levels of disturbance in the late 19th Century and parallel lake and forest hollow sediments record variable pollen influx (beetle host / non-host ratios) and stratigraphies that include mineral in-wash events. The identified recent

  7. Human papillomavirus vaccines, complex regional pain syndrome, postural orthostatic tachycardia syndrome, and autonomic dysfunction - a review of the regulatory evidence from the European Medicines Agency

    DEFF Research Database (Denmark)

    Jefferson, Tom; Jørgensen, Lars

    2017-01-01

    Recent concerns about a possible association between exposure of young women to human papillomavirus (HPV) vaccines and two "dysautonomic syndromes" (a collection of signs and symptoms thought to be caused by autoimmunity) - complex regional pain syndrome (CRPS) and postural orthostatic tachycardia...

  8. The Knowledge and Uptake of Travel Vaccine Among Medical Doctors in a Tertiary Health Institution in Plateau State, North Central Nigeria.

    Science.gov (United States)

    Hassan, Zuwaira Ibrahim; Afolaranmi, Tolulope O

    2015-01-01

    Travelers play a significant role in the spread of infectious diseases across international borders, through their travel patterns and behaviors. Travel maybe the only risk factor for infectious diseases that are well controlled in the travelers' country of residence, particularly vaccine-preventable diseases. The role of vaccination among travelers is an essential component of the control of travel-associated infectious diseases. This study was conducted to assess the knowledge and uptake of travel vaccine among medical doctors in Jos University Teaching Hospital (JUTH). This was a descriptive cross-sectional study conducted in 2013 using quantitative method of data collection among 189 medical doctors. Epi Info™ statistical software package version 3.5.4 was used for data analysis and a P ≤ 0.05 was considered statistically significant. The mean age of the respondents was 33.8 ± 4.5 years, majority of the respondents (96.3%) were aware of travel vaccines with 45 (71.4%) of the 63 respondents who had embarked on international travel prior to the study had taken travel vaccine in their last travel. Knowledge of travel vaccination was found to have statistically significant relationship with uptake of travel vaccine (P = 0.013). This study has revealed the need to improve the knowledge and uptake of travel vaccine among medical doctors.

  9. The knowledge and uptake of travel vaccine among medical doctors in a tertiary health institution in Plateau State, North Central Nigeria

    Directory of Open Access Journals (Sweden)

    Zuwaira Ibrahim Hassan

    2015-01-01

    Full Text Available Background: Travelers play a significant role in the spread of infectious diseases across international borders, through their travel patterns and behaviors. Travel maybe the only risk factor for infectious diseases that are well controlled in the travelers′ country of residence, particularly vaccine-preventable diseases. The role of vaccination among travelers is an essential component of the control of travel-associated infectious diseases. This study was conducted to assess the knowledge and uptake of travel vaccine among medical doctors in Jos University Teaching Hospital (JUTH. Materials and Methods: This was a descriptive cross-sectional study conducted in 2013 using quantitative method of data collection among 189 medical doctors. Epi Info™ statistical software package version 3.5.4 was used for data analysis and a P ͳ 0.05 was considered statistically significant. Result: The mean age of the respondents was 33.8 ± 4.5 years, majority of the respondents (96.3% were aware of travel vaccines with 45 (71.4% of the 63 respondents who had embarked on international travel prior to the study had taken travel vaccine in their last travel. Knowledge of travel vaccination was found to have statistically significant relationship with uptake of travel vaccine (P = 0.013. Conclusion: This study has revealed the need to improve the knowledge and uptake of travel vaccine among medical doctors.

  10. Barcoding of Central European Cryptops centipedes reveals large interspecific distances with ghost lineages and new species records from Germany and Austria (Chilopoda, Scolopendromorpha)

    Science.gov (United States)

    Wesener, Thomas; Voigtländer, Karin; Decker, Peter; Oeyen, Jan Philip; Spelda, Jörg

    2016-01-01

    Abstract In order to evaluate the diversity of Central European Myriapoda species in the course of the German Barcode of Life project, 61 cytochrome c oxidase I sequences of the genus Cryptops Leach, 1815, a centipede genus of the order Scolopendromorpha, were successfully sequenced and analyzed. One sequence of Scolopendra cingulata Latreille, 1829 and one of Theatops erythrocephalus Koch, 1847 were utilized as outgroups. Instead of the expected three species (Cryptops parisi Brolemann, 1920; Cryptops anomalans Newport, 1844; Cryptops hortensis (Donovan, 1810)), analyzed samples included eight to ten species. Of the eight clearly distinguishable morphospecies of Cryptops, five (Cryptops parisi; Cryptops croaticus Verhoeff, 1931; Cryptops anomalans; Cryptops umbricus Verhoeff, 1931; Cryptops hortensis) could be tentatively determined to species level, while a further three remain undetermined (one each from Germany, Austria and Croatia, and Slovenia). Cryptops croaticus is recorded for the first time from Austria. A single specimen (previously suspected as being Cryptops anomalans), was redetermined as Cryptops umbricus Verhoeff, 1931, a first record for Germany. All analyzed Cryptops species are monophyletic and show large genetic distances from one another (p-distances of 13.7–22.2%). Clear barcoding gaps are present in lineages represented by >10 specimens, highlighting the usefulness of the barcoding method for evaluating species diversity in centipedes. German specimens formally assigned to Cryptops parisi are divided into three clades differing by 8.4–11.3% from one another; their intra-lineage genetic distance is much lower at 0–1.1%. The three clades are geographically separate, indicating that they might represent distinct species. Aside from Cryptops parisi, intraspecific distances of Cryptops spp. in Central Europe are low (<3.3%). PMID:27081331

  11. The near real time Forensic Disaster Analysis of the central European flood in June 2013 - A graphical representation of the main results

    Science.gov (United States)

    Schröter, Kai; Elmer, Florian; Trieselmann, Werner; Kreibich, Heidi; Kunz, Michael; Khazai, Bijan; Dransch, Doris; Wenzel, Friedemann; Zschau, Jochen; Merz, Bruno; Mühr, Bernhard; Kunz-Plapp, Tina; Möhrle, Stella; Bessel, Tina; Fohringer, Joachim

    2014-05-01

    The Central European flood of June 2013 is one of the most severe flood events that have occurred in Central Europe in the past decades. All major German river basins were affected (Rhine, Danube, and Elbe as well as the smaller Weser catchment).In terms of spatial extent and event magnitude, it was the most severe event at least since 1950. Within the current research focus on near real time forensic disaster analysis, the Center for Disaster Management and Risk Reduction Technology (CEDIM) assessed and analysed the multiple facets of the flood event from the beginning. The aim is to describe the on-going event, analyse the event sources, link the physical characteristics to the impact and consequences of the event and to understand the root causes that turn the physical event into a disaster (or prevent it from becoming disastrous). For the near real time component of this research, tools for rapid assessment and concise presentation of analysis results are essential. This contribution provides a graphical summary of the results of the CEDIM-FDA analyses on the June 2013 flood. It demonstrates the potential of visual representations for improving the communication and hence usability of findings in a rapid, intelligible and expressive way as a valuable supplement to usual event reporting. It is based on analyses of the hydrometeorological sources, the flood pathways (from satellite imagery, data extraction from social media), the resilience of the affected regions, and causal loss analysis. The prototypical representation of the FDA-results for the June 2013 flood provides an important step in the development of graphical event templates for the visualisation of forensic disaster analyses. These are intended to become a standard component of future CEDIM-FDA event activities.

  12. [Travelers' vaccines].

    Science.gov (United States)

    Ouchi, Kazunobu

    2011-09-01

    The number of Japanese oversea travelers has gradually increased year by year, however they usually pay less attention to the poor physical condition at the voyage place. Many oversea travelers caught vaccine preventable diseases in developing countries. The Vaccine Guideline for Oversea Travelers 2010 published by Japanese Society of Travel Health will be helpful for spreading the knowledge of travelers' vaccine and vaccine preventable diseases in developing countries. Many travelers' vaccines have not licensed in Japan. I hope these travelers' vaccines, such as typhoid vaccine, meningococcal vaccine, cholera vaccine and so on will be licensed in the near future.

  13. Opening the treasure chest: A DNA-barcoding primer set for most higher taxa of Central European birds and mammals from museum collections.

    Science.gov (United States)

    Schäffer, Sylvia; Zachos, Frank E; Koblmüller, Stephan

    2017-01-01

    DNA-barcoding is a rapidly developing method for efficiently identifying samples to species level by means of short standard DNA sequences. However, reliable species assignment requires the availability of a comprehensive DNA barcode reference library, and hence numerous initiatives aim at generating such barcode databases for particular taxa or geographic regions. Historical museum collections represent a potentially invaluable source for the DNA-barcoding of many taxa. This is particularly true for birds and mammals, for which collecting fresh (voucher) material is often very difficult to (nearly) impossible due to the special animal welfare and conservation regulations that apply to vertebrates in general, and birds and mammals in particular. Moreover, even great efforts might not guarantee sufficiently complete sampling of fresh material in a short period of time. DNA extracted from historical samples is usually degraded, such that only short fragments can be amplified, rendering the recovery of the barcoding region as a single fragment impossible. Here, we present a new set of primers that allows the efficient amplification and sequencing of the entire barcoding region in most higher taxa of Central European birds and mammals in six overlapping fragments, thus greatly increasing the value of historical museum collections for generating DNA barcode reference libraries. Applying our new primer set in recently established NGS protocols promises to further increase the efficiency of barcoding old bird and mammal specimens.

  14. Environment vs. Plant Ontogeny: Arthropod Herbivory Patterns on European Beech Leaves along the Vertical Gradient of Temperate Forests in Central Germany

    Directory of Open Access Journals (Sweden)

    Stephanie Stiegel

    2018-01-01

    Full Text Available Environmental and leaf trait effects on herbivory are supposed to vary among different feeding guilds. Herbivores also show variability in their preferences for plant ontogenetic stages. Along the vertical forest gradient, environmental conditions change, and trees represent juvenile and adult individuals in the understorey and canopy, respectively. This study was conducted in ten forests sites in Central Germany for the enrichment of canopy research in temperate forests. Arthropod herbivory of different feeding traces was surveyed on leaves of Fagus sylvatica Linnaeus (European beech; Fagaceae in three strata. Effects of microclimate, leaf traits, and plant ontogenetic stage were analyzed as determining parameters for herbivory. The highest herbivory was caused by exophagous feeding traces. Herbivore attack levels varied along the vertical forest gradient for most feeding traces with distinct patterns. If differences of herbivory levels were present, they only occurred between juvenile and adult F. sylvatica individuals, but not between the lower and upper canopy. In contrast, differences of microclimate and important leaf traits were present between the lower and upper canopy. In conclusion, the plant ontogenetic stage had a stronger effect on herbivory than microclimate or leaf traits along the vertical forest gradient.

  15. Vaccines for canine leishmaniasis.

    Science.gov (United States)

    Palatnik-de-Sousa, Clarisa B

    2012-01-01

    Leishmaniasis is the third most important vector-borne disease worldwide. Visceral leishmaniasis (VL) is a severe and frequently lethal protozoan disease of increasing incidence and severity due to infected human and dog migration, new geographical distribution of the insect due to global warming, coinfection with immunosuppressive diseases, and poverty. The disease is an anthroponosis in India and Central Africa and a canid zoonosis (ZVL) in the Americas, the Middle East, Central Asia, China, and the Mediterranean. The ZVL epidemic has been controlled by one or more measures including the culling of infected dogs, treatment of human cases, and insecticidal treatment of homes and dogs. However, the use of vaccines is considered the most cost-effective control tool for human and canine disease. Since the severity of the disease is related to the generation of T-cell immunosuppression, effective vaccines should be capable of sustaining or enhancing the T-cell immunity. In this review we summarize the clinical and parasitological characteristics of ZVL with special focus on the cellular and humoral canine immune response and review state-of-the-art vaccine development against human and canine VL. Experimental vaccination against leishmaniasis has evolved from the practice of leishmanization with living parasites to vaccination with crude lysates, native parasite extracts to recombinant and DNA vaccination. Although more than 30 defined vaccines have been studied in laboratory models no human formulation has been licensed so far; however three second-generation canine vaccines have already been registered. As expected for a zoonotic disease, the recent preventive vaccination of dogs in Brazil has led to a reduction in the incidence of canine and human disease. The recent identification of several Leishmania proteins with T-cell epitopes anticipates development of a multiprotein vaccine that will be capable of protecting both humans and dogs against VL.

  16. Vaccines for canine leishmaniasis

    Directory of Open Access Journals (Sweden)

    Clarisa B. Palatnik-De-Sousa

    2012-04-01

    Full Text Available Leishmaniasis is the third most important vector-borne disease worldwide. Visceral leishmaniasis (VL is a severe and frequently lethal protozoan disease of increasing incidence and severity due to infected human and dog migration, new geographical distribution of the insect due to global-warming, co-infection with immunosuppressive diseases and poverty. The disease is an anthroponosis in India and Central Africa and a canid zoonosis (ZVL in the Americas, the Middle East, Central Asia, China and the Mediterranean. The ZVL epidemic has been controlled by one or more measures including the culling of infected dogs, treatment of human cases and insecticidal treatment of homes and dogs. However, the use of vaccines is considered the most cost-effective control tool for human and canine disease. Since the severity of the disease is related to the generation of T-cell immunosuppression, effective vaccines should be capable of sustaining or enhancing the T-cell immunity. In this review we summarize the clinical and parasitological characteristics of ZVL with special focus on the cellular and humoral canine immune response and review state-of-the-art vaccine development against human and canine visceral leishmaniasis. Experimental vaccination against leishmaniasis has evolved from the practice of leishmanization with living parasites to vaccination with crude lysates, native parasite extracts to recombinant and DNA vaccination. Although more than 30 defined vaccines have been studied in laboratory models no human formulation has been licensed so far; however three second-generation canine vaccines have already been registered. As expected for a zoonotic disease, the recent preventive vaccination of dogs in Brazil has led to a reduction in the incidence of canine and human disease. The recent identification of several Leishmania proteins with T-cell epitopes anticipates development of a multiprotein vaccine that will be capable of protecting both humans

  17. Vaccines for Canine Leishmaniasis

    Science.gov (United States)

    Palatnik-de-Sousa, Clarisa B.

    2012-01-01

    Leishmaniasis is the third most important vector-borne disease worldwide. Visceral leishmaniasis (VL) is a severe and frequently lethal protozoan disease of increasing incidence and severity due to infected human and dog migration, new geographical distribution of the insect due to global warming, coinfection with immunosuppressive diseases, and poverty. The disease is an anthroponosis in India and Central Africa and a canid zoonosis (ZVL) in the Americas, the Middle East, Central Asia, China, and the Mediterranean. The ZVL epidemic has been controlled by one or more measures including the culling of infected dogs, treatment of human cases, and insecticidal treatment of homes and dogs. However, the use of vaccines is considered the most cost–effective control tool for human and canine disease. Since the severity of the disease is related to the generation of T-cell immunosuppression, effective vaccines should be capable of sustaining or enhancing the T-cell immunity. In this review we summarize the clinical and parasitological characteristics of ZVL with special focus on the cellular and humoral canine immune response and review state-of-the-art vaccine development against human and canine VL. Experimental vaccination against leishmaniasis has evolved from the practice of leishmanization with living parasites to vaccination with crude lysates, native parasite extracts to recombinant and DNA vaccination. Although more than 30 defined vaccines have been studied in laboratory models no human formulation has been licensed so far; however three second-generation canine vaccines have already been registered. As expected for a zoonotic disease, the recent preventive vaccination of dogs in Brazil has led to a reduction in the incidence of canine and human disease. The recent identification of several Leishmania proteins with T-cell epitopes anticipates development of a multiprotein vaccine that will be capable of protecting both humans and dogs against VL. PMID:22566950

  18. Measles vaccine coverage and immune response in children of Caiabi and Metuktire Indian tribes living in malarial endemic area: Parque indígena do Xingu, Central Brazil.

    Science.gov (United States)

    Spindel, R; Baruzzi, R G; Souza, V A; Ferreira, A W; Avila, S L

    2001-07-01

    Measles vaccination efficiency was evaluated in children from two Indian tribes - Caiabi and Metuktire - living in the Amazon region, in the Parque Indigena do Xingu (PIX). The population sample, selected at random, made up 37 Caiabi and 28 Metuktire children, aged from 20-75 months (40%). For operational and epidemiological reasons, measles vaccine is given from 6 months of age. The average age of children when they received the vaccine was 11.5 months for the first dose and 20 months for the second. The search for IgG antibodies against measles virus and Plasmodium falciparum was made through immunofluorescence assay (IFA). Measles vaccine coverage has reached 60% at 12 months of age and 92% at 18 months, whereas post-vaccine serum conversion was 95% in Caiabi children (geometric mean of titres (GMT) 126) and 89% in Metuktire (GMT 109). The difference in GMT is not statistically significant. Seventy-three per cent of Caiabi children (GMT 101) and 100% of Metuktire children (GMT135) were plasmodium antibody positive, showing they had been exposed to malarial infection. Despite the differences detected, the immune response to measles vaccine was satisfactory in both groups, with a positive percentage consistent with that achieved in non-malarial areas in Americas. The results show the efficiency of a vaccination programme in an indigenous area despite the difficulties in reaching the villages and maintaining the cold chain, and also despite the malaria endemicity.

  19. Acceptability of Aujeszky's disease vaccines.

    Science.gov (United States)

    Kimman, T G

    1992-01-01

    Vaccines against Aujeszky's disease are not only used to prevent the clinical consequences of a field infection, but also to support eradication of the virus. The current Aujeszky's disease vaccines (ADV) protect against severe clinical signs of disease and they reduce but usually do not prevent virus multiplication and excretion or the establishment of latency after infection. Vaccines also limit virus multiplication after reactivation. The efficacy of vaccination is reduced by passively acquired maternal antibodies. The mechanisms that afford immunity to the virus are only poorly understood. No simple parameters for immunity are therefore available. The European Pharmacopoeia formulates requirements for inactivated and live ADV vaccines for parenteral use. The vaccines must be safe; they must not induce local or systemic reactions; they must not be transmitted to unvaccinated pigs; they must not be transmitted by semen and across the placenta; the attenuation must be irreversible (live vaccines); the inactivation must be complete (inactivated vaccines); they must prevent mortality and limit growth retardation after challenge infection; the vaccine must not contain contaminating micro-organisms and viruses. No requirements have been formulated with regard to reduction of excretion of challenge virus after experimental infection, efficacy in pigs with maternal antibodies, reproducibility of efficacy studies, reduction of virus transmission under field conditions, the presence of a serological marker, safety for other species, and safety and efficacy of intranasally administered vaccines. Future developments should be directed to the development and evaluation of ADV vaccines that are able to limit transmission of the virus.

  20. The Knowledge and Uptake of Travel Vaccine Among Medical Doctors in a Tertiary Health Institution in Plateau State, North Central Nigeria

    OpenAIRE

    Hassan, Zuwaira Ibrahim; Afolaranmi, Tolulope O.

    2015-01-01

    Background: Travelers play a significant role in the spread of infectious diseases across international borders, through their travel patterns and behaviors. Travel maybe the only risk factor for infectious diseases that are well controlled in the travelers′ country of residence, particularly vaccine-preventable diseases. The role of vaccination among travelers is an essential component of the control of travel-associated infectious diseases. This study was conducted to assess the knowledge a...

  1. Habitat use by the european wild rabbit (Oryctolagus cuniculus in a coastal sandy dune ecosystem of central italy

    Directory of Open Access Journals (Sweden)

    Francesco Santilli

    2010-08-01

    Full Text Available Abstract
    The European wild rabbit (Oryctolagus cuniculus has been recurrently introduced into Italy since the Roman times. Some populations occur along sandy coastal dunes (Central Italy. There is no information about the ecology and habitat preferences of wild rabbits in this particular ecosystem. During May and June 2009, we assessed the distribution of wild rabbits in a 120 ha protected area (province of Livorno, Tuscany, by faecal pellet counts in 170 circular plots (d = 1 m. Range size defined by Kernel Analysis was 27.3 ha (95% and 13.2 ha (50%. Habitat selection was assessed through Jacobs’ index of selection. Rabbits selected the first dunes that offer both food (psammophilous grasses and the cover of tamarisk shrubs. Holm oak woods and pinewoods were avoided, probably because of the lack of undergrowth.

    Riassunto
    Uso dell'habitat da parte del coniglio selvatico (Oryctolagus cuniculus in un ecosistema dunale costiero dell’Italia centrale. In Italia sono presenti diverse popolazioni di coniglio selvatico (Oryctolagus cuniculus derivanti da introduzioni effettuate in epoche diverse. Alcune di queste sono localizzate lungo le coste sabbiose della Toscana. Le informazioni sull’ecologia e sulle preferenze ambientali delle popolazioni che vivono in questi particolari ecosistemi sono molto carenti. In questo studio è stato analizzato l’uso dell'habitat da parte del coniglio selvatico in un area costiera protetta della provincia di Livorno delle dimensioni di 120 ha. La distribuzione di questo lagomorfo è stata stimata nel periodo maggio - giugno 2009 in base alla presenza/assenza delle feci in 170 cerchi campione di 1 m di diametro. L’areale occupato dalla specie è stato definito tramite Kernel Analysis al 95% (27.3 ha e 50% (13.2 ha. La selezione di habitat è stata stimata tramite l’indice di Jacobs. Il coniglio selvatico

  2. After the flood is before the next flood - post event review of the Central European Floods of June 2013. Insights, recommendations and next steps for future flood prevention

    Science.gov (United States)

    Szoenyi, Michael; Mechler, Reinhard; McCallum, Ian

    2015-04-01

    In early June 2013, severe flooding hit Central and Eastern Europe, causing extensive damage, in particular along the Danube and Elbe main watersheds. The situation was particularly severe in Eastern Germany, Austria, Hungary and the Czech Republic. Based on the Post Event Review Capability (PERC) approach, developed by Zurich Insurance's Flood Resilience Program to provide independent review of large flood events, we examine what has worked well (best practice) and opportunities for further improvement. The PERC overall aims to thoroughly examine aspects of flood resilience, flood risk management and catastrophe intervention in order to help build back better after events and learn for future events. As our research from post event analyses shows a lot of losses are in fact avoidable by taking the right measures pre-event and these measures are economically - efficient with a return of 4 Euro on losses saved for every Euro invested in prevention on average (Wharton/IIASA flood resilience alliance paper on cost benefit analysis, Mechler et al. 2014) and up to 10 Euros for certain countries. For the 2013 flood events we provide analysis on the following aspects and in general identify a number of factors that worked in terms of reducing the loss and risk burden. 1. Understanding risk factors of the Central European Floods 2013 We review the precursors leading up to the floods in June, with an extremely wet May 2013 and an atypical V-b weather pattern that brought immense precipitation in a very short period to the watersheds of Elbe, Donau and partially the Rhine in the D-A-CH countries and researched what happened during the flood and why. Key questions we asked revolve around which protection and risk reduction approaches worked well and which did not, and why. 2. Insights and recommendations from the post event review The PERC identified a number of risk factors, which need attention if risk is to be reduced over time. • Yet another "100-year flood" - risk

  3. Genome-wide association study and genetic diversity analysis on nitrogen use efficiency in a Central European winter wheat (Triticum aestivum L. collection.

    Directory of Open Access Journals (Sweden)

    István Monostori

    Full Text Available To satisfy future demands, the increase of wheat (Triticum aestivum L. yield is inevitable. Simultaneously, maintaining high crop productivity and efficient use of nutrients, especially nitrogen use efficiency (NUE, are essential for sustainable agriculture. NUE and its components are inherently complex and highly influenced by environmental factors, nitrogen management practices and genotypic variation. Therefore, a better understanding of their genetic basis and regulation is fundamental. To investigate NUE-related traits and their genetic and environmental regulation, field trials were evaluated in a Central European wheat collection of 93 cultivars at two nitrogen input levels across three seasons. This elite germplasm collection was genotyped on DArTseq® genotypic platform to identify loci affecting N-related complex agronomic traits. To conduct robust genome-wide association mapping, the genetic diversity, population structure and linkage disequilibrium were examined. Population structure was investigated by various methods and two subpopulations were identified. Their separation is based on the breeding history of the cultivars, while analysis of linkage disequilibrium suggested that selective pressures had acted on genomic regions bearing loci with remarkable agronomic importance. Besides NUE, genetic basis for variation in agronomic traits indirectly affecting NUE and its components, moreover genetic loci underlying response to nitrogen fertilisation were also determined. Altogether, 183 marker-trait associations (MTA were identified spreading over almost the entire genome. We found that most of the MTAs were environmental-dependent. The present study identified several associated markers in those genomic regions where previous reports had found genes or quantitative trait loci influencing the same traits, while most of the MTAs revealed new genomic regions. Our data provides an overview of the allele composition of bread wheat

  4. Barriers to access to opioid medicines for patients with opioid dependence: a review of legislation and regulations in eleven central and eastern European countries.

    Science.gov (United States)

    Vranken, Marjolein J M; Mantel-Teeuwisse, Aukje K; Jünger, Saskia; Radbruch, Lukas; Scholten, Willem; Lisman, John A; Subataite, Marija; Schutjens, Marie-Hélène D B

    2017-06-01

    Barriers linked to drug control systems are considered to contribute to inequitable access to controlled medicines, leaving millions of people in pain and suffering. Most studies focus on access to opioids for the treatment of severe (cancer) pain. This study aims to identify specific access barriers for patients with opioid dependence in legislation and regulations of 11 central and eastern European countries. This study builds on a previous analysis of legislation and regulations as part of the EU 7th Framework Access To Opioid Medication in Europe (ATOME) project. An in-depth analysis was undertaken to determine specific barriers for patients with opioid dependence in need of opioid analgesics or opioid agonist therapy (OAT). For each country, the number and nature of specific potential barriers for these patients were assessed according to eight categories: prescribing; dispensing; manufacturing; usage; trade and distribution; affordability; penalties; and other. An additional keyword search was conducted to minimize the omission of barriers. Barriers in an additional category, language, were recorded qualitatively. Countries included Bulgaria, Cyprus, Estonia, Greece, Hungary, Latvia, Lithuania, Serbia, Slovakia, Slovenia and Turkey. Ten of the 11 countries (all except Estonia) showed specific potential barriers in their legislation and regulations. The total number of barriers varied from two (Slovenia) to 46 (Lithuania); the number of categories varied from one (Slovenia) to five (Lithuania). Most specific potential barriers were shown in the categories 'prescribing', 'usage' and 'other'. The total number in a single category varied from one to 18 (Lithuania, prescribing). Individual differences between countries in the same specific potential barrier were shown; for example, variation in minimum age criteria for admission to OAT ranging from 15 (Lithuania, in special cases) to 20 years (Greece). All countries had stigmatizing language in their legislation

  5. Emergence and establishment of Usutu virus infection in wild and captive avian species in and around Zurich, Switzerland--genomic and pathologic comparison to other central European outbreaks.

    Science.gov (United States)

    Steinmetz, Hanspeter W; Bakonyi, Tamás; Weissenböck, Herbert; Hatt, Jean-Michel; Eulenberger, Ulrike; Robert, Nadia; Hoop, Richard; Nowotny, Norbert

    2011-03-24

    In late summer 2006 considerable mortality in wild and captive Passeriformes and Strigiformes was observed in Zurich, Switzerland. All animals were found in a range of 2 km(2). Observed clinical signs involved depression, ruffled plumage, incoordination, seizures and peracute death. Nutritional status was generally moderate to poor in wild birds, and variable in captive animals. Necropsy showed marked splenomegaly, a mild hepatomegaly, and pulmonary hyperemia in most animals. Histopathologic lesions were very discrete and consisted mainly of neuronal necrosis, leucocytolysis in and around the brain blood vessels, and miliary liver necrosis. The diagnosis Usutu virus (USUV) infection was established by USUV-specific immunohistochemistry and reverse transcription-polymerase chain reaction. Partial nucleotide sequence comparisons revealed>99% identity between the viruses that emerged in Zurich in 2006, in Vienna in 2001, and in Budapest in 2005. Since 2008 a significantly lower mortality was observed in wild Passeriformes, but USUV infection was confirmed for the first time beyond Zurich city limits. Indoor housing and regular treatment against ectoparasites are likely to have prevented acute USUV disease in captive Strigiformes. USUV is a mosquito-borne flavivirus causing fatalities in various avian species. After the initial European outbreaks in Austria in 2001 it appears that the virus has extended its range in Central Europe and has established a transmission cycle between local bird and mosquito species. Further episodes of increased avian mortality in the forthcoming years, with impact on wild and captive bird populations, predominantly Passeriformes and Strigiformes, can be anticipated. Furthermore, the possibility of broader dispersal of USUV in Europe during the next mosquito seasons must be considered and an increased mortality in Passeriformes and Strigiformes must be expected until protective "flock immunity" is established. Collections of valuable and

  6. Credit risk determinants in Sub-Saharan banking systems: Evidence from five countries and lessons learnt from Central East and South East European countries

    Directory of Open Access Journals (Sweden)

    Eftychia Nikolaidou

    2017-06-01

    Full Text Available Banking systems in Sub-Saharan Africa (SSA have grown notably over the past decades due to benign macroeconomic, regulatory and financial trends. Nonetheless, downside risks remain elevated by structural issues, commodity price fluctuations, reversal of capital flows and spill-over effects from external shocks in a manner similar to the Central East and South East European (CESEE countries. In the light of the 2008–2009 Global Financial Crisis, great attention has been given to understanding the causes of banking instability with most of the research focusing on advanced economies and, to a lesser extent, large emerging markets while little attention has been paid to the bank-based financial sectors of Sub-Saharan Africa. Furthermore, there is scarcity of studies aiming at knowledge-sharing among different emerging economies. This paper aims to identify the determinants of bank credit risk by focusing on five SSA countries: Kenya, Namibia, South Africa, Zambia and Uganda. Using the ARDL approach to cointegration, findings indicate that increased money supply conditions have a decreasing effect on NPLs in all counties, banking industry-specific variables play a significant role in the case of South Africa and Uganda while NPLs are driven by country-specific variables in the case of Kenya, South Africa and Zambia. The effect of the Global Financial Crisis is evidenced indirectly. Drawing on evidence from CESEE countries with long experience in banking crises, reforms and financial deepening process, the paper provides lessons for SSA countries and offers policy recommendations in the direction of strengthening banks’ balance sheets to ensure financial stability.

  7. THE ANALYTICAL INSIGHT INTO CUSTOMER PERCEPTION OF QUALITY DETERMINANTS OF THE E-COMMERCE MODEL BUSINESS-TO-CONSUMER SUBJECTS IN THE CENTRAL EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Radovan Bačík

    2014-12-01

    Full Text Available Purpose: The aim of the paper is to describe the specific aspects of the e-commerce model business-to-consumer as a constantly developing field of an economic life in the Central European countries according to their customers. The current state of e-business and business-to-consumer e-commerce issue was identified by the research in the Czech Republic, Hungary, Poland and Slovakia.Methodology/Approach: For the purposes of collecting primary data the crucial factor for the selection of e-shops was identification of the suitable  online portals focused on post-purchase evaluation of e-shops in Visegrad group countries. Automatic data collection method was used for the observed variables (evaluations within selected online portals of the identified e-shops. The total of 5,228,127 evaluations of 9,260 e-shops were analysed. The main focus was given to customer overall satisfaction with an e-shop in relation to communication with a customer or overall satisfaction with an e-shop and delivery quality.Findings: The results of the research showed that there exists a direct relation between overall satisfaction with an e-shop and communication with customers or overall satisfaction with an e-shop and delivery quality.Originality/Value of paper: The ambition of this paper through the findings is to help subjects of e-commerce in their marketing decisions in order to even better understand the factors that influence customers’ satisfaction. 

  8. Trends in the non-steroidal anti-inflammatory drug market in six Central-Eastern European countries based on retail information.

    Science.gov (United States)

    Inotai, András; Hankó, Balázs; Mészáros, Agnes

    2010-02-01

    The objective of this study was to evaluate the non-steroidal anti-inflammatory drug market of six Central and Eastern European countries. Trends and similarities were compared across the examined countries. The Intercontinental Marketing Service Health database was used to determine consumption data between the years 2000 and 2007. We applied the anatomical therapeutical chemical-defined daily dose method, focussing on three major non-steroidal anti-inflammatory drug groups: conventional non-steroidal anti-inflammatory drugs, 'stronger cyclooxygenase 2 inhibitors' (all together as: non-cyclooxygenase 2 selective non-steroidal anti-inflammatory drugs) and selective cyclooxygenase 2 inhibitors. The main outcome measure was defined daily dose/1000 inhabitants/day. Different active agents have been distinguished between the three major groups. In total the non-steroidal anti-inflammatory drug group reached a 42.82-74.17 defined daily dose/1000 inhabitants/day volume in 2007, with an average total increase of 25.1% between 2002 and 2007. In the conventional non-steroidal anti-inflammatory drug group, diclofenac and ibuprofen have attained the highest consumption. Our results show a notable increase (325%, 2002-2007) of the 'stronger cyclooxygenase 2 inhibitor group' (nimesulide and meloxicam). Trends of selective cyclooxygenase 2 inhibitor volumes differ within the observed countries. Differences in the six countries concerning their NSAID consumption and market trends could not be explained with the inequalities in patient characteristics. The conventional NSAID retail gave the majority of the total NSAID market. The consumption of selective COX2 inhibitors in all of the six countries were much lower than in the US or Australia. The NSAID risk profile in the region is comparable to previous studies in other countries. Copyright (c) 2009 John Wiley & Sons, Ltd.

  9. Attempt to increase the transparency of fourth hurdle implementation in Central-Eastern European middle income countries: publication of the critical appraisal methodology

    Directory of Open Access Journals (Sweden)

    Inotai András

    2012-09-01

    quality of their economic evaluation. Conclusions The transparent critical appraisal method should improve the consistency of pharmaceutical reimbursement decisions and facilitate the utilization of economic evaluations in other fields of health care decision-making in other Central-Eastern European countries.

  10. Attempt to increase the transparency of fourth hurdle implementation in Central-Eastern European middle income countries: publication of the critical appraisal methodology.

    Science.gov (United States)

    Inotai, András; Pékli, Márta; Jóna, Gabriella; Nagy, Orsolya; Remák, Edit; Kaló, Zoltán

    2012-09-21

    critical appraisal method should improve the consistency of pharmaceutical reimbursement decisions and facilitate the utilization of economic evaluations in other fields of health care decision-making in other Central-Eastern European countries.

  11. Household appliance data collection and market survey in central and eastern european countries; Raccolta dati e analisi del mercato sugli apparecchi elettrodomestici nei paesi dell'Europa centrale e orientale

    Energy Technology Data Exchange (ETDEWEB)

    Presutto, M. [ENEA, Funzione Centrali Studi, Centro Ricerche Ispra, Vercelli (Italy); Ricci, A. [Istituto di Studi per l' Integrazione dei Sistemi, Rome (Italy); Meli, L. [ANIE, Federazione delle Imprese Elettrotecniche ed Elettroniche, International Affaires Direction, Milan (Italy)

    2001-07-01

    Since 1995 the European Commission, through the SAVE programme, and the Economic Commission for Europe of the United Nations, through the Energy Efficiency 2000 Project, jointly sponsored the so called SACHA projects in Central and Eastern European Countries regarding major household appliances. Consistently, the main objective of the projects was to analyse and interpret the situation of refrigerators, freezers and washing machines in seven CEEC, so as to increase the knowledge and understanding of the issues at stake in the area of energy efficiency and environmental friendliness, and therefore to identify possible scenarios of improvement. This paper describes the work accomplished and the results achieved in this context, focusing more on the data collection and market survey moments and illustrates, with an abundant series of exhibits, the quantitative picture resulting form the analyses carried out. Possibility exists for replication in Latin America, where ENEA and Italian experience could be fruitfully applied. Reliable and complete information is in fact one of the prerequisites to overcome potential barriers and facilitate a successful enforcement of any energy efficiency policy. Effective implementation and regional harmonisation are necessary, even if projects can facilitate the fulfilment of these goals as it provides a consolidated methodology and an integrated scheme for basic data collection and analysis. [Italian] A partire dal 1995 la Commissione Europea e la Commissione Economica per l'Europa delle Nazioni Unite hanno congiuntamente promosso lo studio dei piu' importanti apparecchi domestici nei paesi dell'Europa centrale ed orientale. Principale obiettivo di questi progetti, piu' noti come progetti con SACHA, dall'acronimo del titolo, era analizzare e soprattutto interpretare la situazione dei frigoriferi, congelatori e lavatrici in sette PECO, per migliorare da un lato la conoscenza e la comprensione delle problematiche

  12. Europeanization and transnational states

    DEFF Research Database (Denmark)

    Jacobsson, Bengt; Lægreid, Per; Pedersen, Ove K.

    This work investigates what happens to an organized political unit when it becomes part of a larger entity and, in particular, how increased European integration and the tentative moves towards a transnational state will affect the European Union's nation state. Europeanization and the transforma......This work investigates what happens to an organized political unit when it becomes part of a larger entity and, in particular, how increased European integration and the tentative moves towards a transnational state will affect the European Union's nation state. Europeanization...... in central government agencies. It concludes that the consequences of Europeanization can be described as the growth of a transnational administration where identities as well as loyalties are created in processes that transcend the borders of states....

  13. Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011

    Directory of Open Access Journals (Sweden)

    Ruffin Nicolas

    2012-07-01

    Full Text Available Abstract Europrise is a Network of Excellence supported by the European Commission within the 6th Framework programme from 2007 to 2012. The Network has involved over 50 institutions from 13 European countries together with 3 industrial partners and 6 African countries. The Network encompasses an integrated program of research, training, dissemination and advocacy within the field of HIV vaccines and microbicides. A central and timely theme of the Network is the development of the unique concept of co-usage of vaccines and microbicides. Training of PhD students has been a major task, and some of these post-graduate students have here summarized novel ideas emanating from presentations at the last annual Europrise meeting in Prague. The latest data and ideas concerning HIV vaccine and microbicide studies are included in this review; these studies are so recent that the majority have yet to be published. Data were presented and discussed concerning novel immunisation strategies; microbicides and PrEP (alone and in combination with vaccines; mucosal transmission of HIV/SIV; mucosal vaccination; novel adjuvants; neutralizing antibodies; innate immune responses; HIV/SIV pathogenesis and disease progression; new methods and reagents. These – necessarily overlapping topics - are comprehensively summarised by the Europrise students in the context of other recent exciting data.

  14. Polio Vaccine

    Science.gov (United States)

    ... doctorMost kids have no problems with the polio vaccine. However, call your doctor if your child has any reaction after getting the vaccine. Call ... Tell the doctor when (day and time) your child received the vaccine. You also should file a Vaccine Adverse Event ...

  15. Evidence that radio-sensitive cells are central to skin-phase protective immunity in CBA/Ca mice vaccinated with radiation-attenuated cercariae of Schistosoma mansoni as well as in naive mice protected with vaccine serum

    Energy Technology Data Exchange (ETDEWEB)

    Delgado, V.S.; McLaren, D.J. (National Inst. for Medical Research, London (UK))

    1990-02-01

    Naive CBA/Ca mice and CBA/ca mice vaccinated 4 weeks previously with radiation-attenuated cercariae of Schistosoma mansoni were subjected to 550 rad of whole body (gamma) irradiation and then challenged 3 days later with normal cercariae. The perfusion recovery data showed that this procedure reduced the primary worm burden in naive mice by 22% and the challence worm burden in vaccinated mice by 82%. Irradiation also ablated the peripheral blood leucocytes of both mouse groups by 90-100% at the time of challenge. Histological data revealed that such treatment caused a dramatic change in number, size and leucocyte composition of cutaneous inflammatory skin reactions that characterize challenged vacccinated mice and are known to entrap invading larvae; cutaneous eosinophils were preferentially abolished by this treatment. Polyvaccine mouse serum that conferred protection passively upon naive recipient mice, failed to protect naive/irradiated mice when administered by the same protocol. Distraction of macrophages by treatment of mice with silica did not affect the establishment of a primary worm burden and reduced the protection exhibited by vaccinated mice by only 16%. These data indicade that radio-sensitive cells are important to both innate and specific acquired resistance in this mouse model and that macrophages contribute only marginally to the expression of vaccine immunity. (author).

  16. The march toward malaria vaccines.

    Science.gov (United States)

    Hoffman, Stephen L; Vekemans, Johan; Richie, Thomas L; Duffy, Patrick E

    2015-11-27

    malaria. Progress during the last few years has been significant, and a first generation malaria candidate vaccine, RTS,S/AS01, is under review by the European Medicines Agency (EMA) for its quality, safety and efficacy under article 58, which allows the EMA to give a scientific opinion about products intended exclusively for markets outside of the European Union. However, much work is in progress to optimize malaria vaccines in regard to magnitude and durability of protective efficacy and the financing and practicality of delivery. Thus, we are hopeful that anti-malaria vaccines will soon be important tools in the battle against malaria. Copyright © 2015 American Journal of Preventive Medicine. Published by Elsevier Ltd.. All rights reserved.

  17. Indicative properties on snow cover based on the results of experimental studies in the winter 2011/12 in the central part of the East European Plain

    Directory of Open Access Journals (Sweden)

    L. M. Kitaev

    2013-01-01

    Full Text Available Local and regional differences in the snow formation were studied in different landscapes of the central part of the East European Plain – within reserves in the Moscow and Tver’ regions (south-north direction; the study period is the winter 2011/12. The observed increase of snow storage in 1.3–1.5 times in the direction south-north is connected, apparently. The difference in the five-day appearance of snow cover maximum is related to differences in regional winter air temperature. Throughout the snow depth and snow storage in spruce are smaller than in deciduous forest – in the ratio of 0.81 in south area and 0.93 in north area; in spruce the large part of solid precipitation is intercepted by the crowns pine trees. Snow stratigraphy at south areas has four layers, six layers at the north area are more variable in snow density and snow storage. Perhaps, gravitational conversion is more noticeable due to larger snow depth. Snow density and snow storage at the open areas are more heterogeneous than in the forest. This is due to sharp fluctuations in air temperature, wind transport and compaction of snow, evaporation from the snow surface. The stratigraphy of snow also reflects the history of winter changes of air temperature and snow accumulation. Common feature for reserves at south and north is the availability of layers with maximum snow storage in the middle of the snow thickness, which were formed during the air temperature drops to the lowest seasonal values in period with increase of snow depth to maximum. Formation of depth hoar in snow thickness are touched everywhere the bottom and middle layers, respectively, it was formed both before and during the period with minimal air temperature. Thus, the results of experimental studies confirm the significance of the differences of individual components of the landscape setting. Analytical conclusions are largely qualitative in nature due to the lack to date of initial information, and

  18. The European free-tailed bat, Tadarida teniotis, in a suburban area of Latina, Latium (Central Italy / Il Molosso di Cestoni, Tadarida teniotis, nell'ambiente suburbano di Latina, Lazio (Italia centrale

    Directory of Open Access Journals (Sweden)

    Luigi Corsetti

    1990-07-01

    Full Text Available Abstract Since April 1983 to March 1990, the author carried out observations on the European free-tailed bat (Tadarida teniotis in a suburban house of Latina. The shelter used by the species was located between the outer wall and the flue of the central heating system. The maximum number of specimens observed at the same time was one male and two females. Some characteristic calls uttered by the male have been noticed. These consisted in several very loud shrill notes often given out in rapid succession. These calls have been heard mainly during the day and at sunset, amid the noise from the city and industries in the surrounding; they lasted about 30 seconds on average (up to 45. These calls were probably given out at times of maximum excitement, perhaps in the pre-mating phase. They were heard more frequently in spring (March-May but also in autumn (October-November. Flight generally occurred at temperatures no lower than 16 °C and from 25 to 60 minutes after sunset, after characteristic loud calls, and coming its habitual shelter. The presence of the European free-tailed bat in this spot may have been influenced by the source of heat represented by the flue, which supplied warmth during the winter months and, at the same time, by the trophic opportunities offered by the vast uncultivated fields in the area, with luxuriant herbaceous vegetation, scattered shrubs and trees, ditches, a few small cane thickets, flooded fields. The flue has not been activated since 1987, but the species has continued to live in the same place until 1590 (last sighting on March 1. The author excludes the presence of the species in the study site before 1983. Riassunto Dall'aprile 1983 al marzo 1990 l'autore ha compiuto osservazioni sul Molosso di Cestoni (Tadarida teniotis, in un'abitazione alla periferia della città di Latina. I1 ricovero abituale della specie è localizzato tra il muro esterno e la canna

  19. Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of west nile virus

    NARCIS (Netherlands)

    B.E. Verstrepen (Babs); Oostermeijer, H. (Herman); Z. Fagrouch (Zahra); Van Heteren, M. (Melanie); H. Niphuis (Henk); Haaksma, T. (Tom); I. Kondova (Ivanela); W. Bogers (Willy); De Filette, M. (Marina); N. Sanders; Stertman, L. (Linda); Magnusson, S. (Sofia); Lörincz, O. (Orsolya); Lisziewicz, J. (Julianna); Barzon, L. (Luisa); Palù, G. (Giorgio); Diamond, M.S. (Michael S.); Chabierski, S. (Stefan); S. Ulbert; E.J. Verschoor (Ernst)

    2014-01-01

    textabstractThe mosquito-borne West Nile virus (WNV) causes human and animal disease with outbreaks in several parts of the world including North America, the Mediterranean countries, Central and East Europe, the Middle East, and Africa. Particularly in elderly people and individuals with an

  20. Vaxjo: A Web-Based Vaccine Adjuvant Database and Its Application for Analysis of Vaccine Adjuvants and Their Uses in Vaccine Development

    Directory of Open Access Journals (Sweden)

    Samantha Sayers

    2012-01-01

    Full Text Available Vaccine adjuvants are compounds that enhance host immune responses to co-administered antigens in vaccines. Vaxjo is a web-based central database and analysis system that curates, stores, and analyzes vaccine adjuvants and their usages in vaccine development. Basic information of a vaccine adjuvant stored in Vaxjo includes adjuvant name, components, structure, appearance, storage, preparation, function, safety, and vaccines that use this adjuvant. Reliable references are curated and cited. Bioinformatics scripts are developed and used to link vaccine adjuvants to different adjuvanted vaccines stored in the general VIOLIN vaccine database. Presently, 103 vaccine adjuvants have been curated in Vaxjo. Among these adjuvants, 98 have been used in 384 vaccines stored in VIOLIN against over 81 pathogens, cancers, or allergies. All these vaccine adjuvants are categorized and analyzed based on adjuvant types, pathogens used, and vaccine types. As a use case study of vaccine adjuvants in infectious disease vaccines, the adjuvants used in Brucella vaccines are specifically analyzed. A user-friendly web query and visualization interface is developed for interactive vaccine adjuvant search. To support data exchange, the information of vaccine adjuvants is stored in the Vaccine Ontology (VO in the Web Ontology Language (OWL format.

  1. Targeting vaccines to dendritic cells

    DEFF Research Database (Denmark)

    Foged, Camilla; Sundblad, Anne; Hovgaard, Lars

    2002-01-01

    to be far superior to that of B-cells and macrophages. DC are localized at strategic places in the body at sites used by pathogens to enter the organism, and are thereby in an optimal position to capture antigens. In general, vaccination strategies try to mimic the invasiveness of the pathogens. DC...... are considered to play a central role for the provocation of primary immune responses by vaccination. A rational way of improving the potency and safety of new and already existing vaccines could therefore be to direct vaccines specifically to DC. There is a need for developing multifunctional vaccine drug...... delivery systems (DDS) with adjuvant effect that target DC directly and induce optimal immune responses. This paper will review the current knowledge of DC physiology as well as the progress in the field of novel vaccination strategies that directly or indirectly aim at targeting DC....

  2. Safe handling of vaccines: the rewards of rigorous routines.

    Science.gov (United States)

    Hefti, Kelly; David, Gerard

    2013-01-01

    A recent report published by the Office of Inspector General (OIG) entitled Vaccines for Children Program: Vulnerabilities in Vaccine Management has brought to public awareness the need for increased attention to safe handling of vaccines. The maximum benefit of receiving vaccines for vaccine-preventable diseases can only be attained when we ensure that safe storage and handling occurs through strict adherence to the vaccine cold chain. This compliance can best be accomplished by identifying a vaccine coordinator that is intimately familiar with the components of the vaccine cold chain and provides the necessary oversight to ensure that all links in the chain are maintained. Utilization of helpful resources, including the Centers for Disease Control and Prevention (CDC) resources related to safe handling of vaccines, is central to a well defined process for vaccine handling. This adherence provides reassurance, both to patients receiving vaccine and providers administering it, that the safest and most effective vaccine is being delivered.

  3. The Europeanness of European cinema: Identity, meaning, globalization

    OpenAIRE

    Willems, Gertjan

    2015-01-01

    According to its editors, the aim of The Europeanness of European cinema is ‘to revisit the issue of the significance of European cinema as a category in the wake of the recent acceleration in transnational filmmaking and globalization as a whole’ (p. 7). Taking the transnational prominence of European cinema as a starting point, the anthology’s introduction presents some brief reflections about what ‘Europeanness’ – the central, overarching concept for the various chapters – has meant histor...

  4. ADULT INFLUENZA VACCINATION GUIDELINE

    African Journals Online (AJOL)

    Infections with the influenza virus and Streptococcus pneumoniae are associated with considerable morbidity and ... for Disease Control and Prevention, Atlanta, Georgia; CNS = central nervous system; COPD = chronic .... During delivery and storage, the vaccine should be kept at. 2 - gcC in cold chain, and stored in the ...

  5. Primary care pediatricians' perceptions of vaccine refusal in europe.

    Science.gov (United States)

    Grossman, Zachi; van Esso, Diego; Del Torso, Stefano; Hadjipanayis, Adamos; Drabik, Anna; Gerber, Andreas; Miron, Dan

    2011-03-01

    An electronic survey assessing primary care pediatricians' estimations and practices regarding parents' vaccination refusal was sent to 395 members of the European Academy of Pediatrics Research in Ambulatory Setting network, with a response rate of 87%. Of respondents who vaccinate in the clinic, 93% estimated the total vaccine refusal rate as refusing parents.

  6. Vaccine Finder

    Science.gov (United States)

    ... list . Showing availability for 25,354 locations. Influenza Vaccine Recommended for everyone greater than or equal to ... which one may be right for you! Flu Vaccines Protects again influenza, commonly called flu, a respiratory ...

  7. Vaccine Safety

    Science.gov (United States)

    ... Search Form Controls Cancel Submit Search The CDC Vaccine Safety Note: Javascript is disabled or is not ... CDC.gov . Recommend on Facebook Tweet Share Compartir Vaccine Adverse Events Reporting System (VAERS) New website and ...

  8. Rotavirus Vaccine

    Science.gov (United States)

    ... are also common in babies with rotavirus.Before rotavirus vaccine, rotavirus disease was a common and serious health ... to 60 died. Since the introduction of the rotavirus vaccine, hospitalizations and emergency visits for rotavirus have dropped ...

  9. Specific memory B cell response and participation of CD4+central and effector memory T cells in mice immunized with liposome encapsulated recombinant NE protein based Hepatitis E vaccine candidate.

    Science.gov (United States)

    Kulkarni, Shruti P; Thanapati, Subrat; Arankalle, Vidya A; Tripathy, Anuradha S

    2016-11-21

    Liposome encapsulated neutralizing epitope protein of Hepatitis E virus (HEV), rNEp, our Hepatitis E vaccine candidate, was shown to be immunogenic and safe in pregnant and non-pregnant mice and yielded sterilizing immunity in rhesus monkeys. The current study in Balb/c mice assessed the levels and persistence of anti-HEV IgG antibodies by ELISA, frequencies of B, memory B, T and memory T cells by flow cytometry and HEV-specific IgG secreting memory B cells by ELISPOT till 420days post immunization (PI) with 5?g rNEp encapsulated in liposome based adjuvant (2 doses, 4weeks apart). Mice immunized with a lower dose (1?g) were assessed only for anamnestic response post booster dose. Vaccine candidate immunized mice (5?g dose) elicited strong anti-HEV IgG response that was estimated to persist for lifetime. At day 120 PI, frequency of memory B cells was higher in immunized mice than those receiving adjuvant alone. Anti-HEV IgG titers were lower in mice immunized with 1?g dose. A booster dose yielded a heightened antibody response in mice with both high (>800GMT, 5?g) and low (?100GMT, 1?g) anti-HEV IgG titers. At day 6th post booster dose, HEV-specific antibody secreting plasma cells (ASCs) were detected in 100% and 50% of mice with high and low anti-HEV IgG titers, respectively, whereas the frequencies of CD4 + central and effector memory T cells were high in mice with high anti-HEV IgG titers only. Taken together, the vaccine candidate effectively generates persistent and anamnestic antibody response, elicits participation of CD4 + memory T cells and triggers memory B cells to differentiate into ASCs upon boosting. This approach of assessing the immunogenicity of vaccine candidate could be useful to explore the longevity of HEV-specific memory response in future HEV vaccine trials in human. Copyright © 2016. Published by Elsevier Ltd.

  10. Vaccination elicits a prominent acute phase response in horses.

    Science.gov (United States)

    Andersen, Susanne A; Petersen, Henrik H; Ersbøll, Annette K; Falk-Rønne, Jørgen; Jacobsen, Stine

    2012-02-01

    European and American guidelines for vaccination against tetanus and influenza in horses recommend annual and annual/semi-annual vaccinations, respectively, against the two pathogens. Too-frequent vaccination may, however, have adverse effects, among other things because an inflammatory response is elicited with subsequent alterations in homeostasis. The objective of the study was to compare the acute phase response (APR) in 10 horses following administration of two different types of vaccines, namely, an inactivated Immune Stimulating COMplex (ISCOM) vaccine and a live recombinant vector vaccine. Blood was sampled before and after vaccination to measure levels of serum amyloid A (SAA), fibrinogen, white blood cell counts (WBC) and iron. Vaccination induced a prominent APR with increased WBC, elevated blood levels of SAA and fibrinogen, and decreased serum iron concentrations. The ISCOM vaccine caused significantly (Phorse owners about convalescence after vaccination. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. Vaccines and Autism: A Tale of Shifting Hypotheses

    OpenAIRE

    Gerber, Jeffrey S.; Offit, Paul A.

    2009-01-01

    Although child vaccination rates remain high, some parental concern persists that vaccines might cause autism. Three specific hypotheses have been proposed: (1) the combination measles-mumps-rubella vaccine causes autism by damaging the intestinal lining, which allows the entrance of encephalopathic proteins; (2) thimerosal, an ethylmercury-containing preservative in some vaccines, is toxic to the central nervous system; and (3) the simultaneous administration of multiple vaccines overwhelms ...

  12. Safety of human papillomavirus vaccines: a review

    Science.gov (United States)

    Stillo, Michela; Carrillo Santisteve, Paloma; Lopalco, Pier Luigi

    2015-01-01

    Introduction: Between 2006 and 2009, two different human papillomavirus virus (HPV) vaccines were licensed for use: a quadrivalent (qHPVv) and a bivalent (bHPVv) vaccine. Since 2008, HPV vaccination programmes have been implemented in the majority of the industrialized countries. Since 2013, HPV vaccination has been part of the national programs of 66 countries including almost all countries in North America and Western Europe. Despite all the efforts made by individual countries, coverage rates are lower than expected. Vaccine safety represents one of the main concerns associated with the lack of acceptance of HPV vaccination both in the European Union/European Economic Area and elsewhere. Areas covered: Safety data published on bivalent and quadrivalent HPV vaccines, both in pre-licensure and post-licensure phase, are reviewed. Expert opinion: Based on the latest scientific evidence, both HPV vaccines seem to be safe. Nevertheless, public concern and rumors about adverse events (AE) represent an important barrier to overcome in order to increase vaccine coverage. Passive surveillance of AEs is an important tool for detecting safety signals, but it should be complemented by activities aimed at assessing the real cause of all suspect AEs. Improved vaccine safety surveillance is the first step for effective communication based on scientific evidence. PMID:25689872

  13. Cancer vaccines: an update with special focus on ganglioside antigens.

    Science.gov (United States)

    Bitton, Roberto J; Guthmann, Marcel D; Gabri, Mariano R; Carnero, Ariel J L; Alonso, Daniel F; Fainboim, Leonardo; Gomez, Daniel E

    2002-01-01

    Vaccine development is one of the most promising and exciting fields in cancer research; numerous approaches are being studied to developed effective cancer vaccines. The aim of this form of therapy is to teach the patient's immune system to recognize the antigens expressed in tumor cells, but not in normal tissue, to be able to destroy these abnormal cells leaving the normal cells intact. In other words, is an attempt to teach the immune system to recognize antigens that escaped the immunologic surveillance and are by it, therefore able to survive and, in time, disseminate. However each research group developing a cancer vaccine, uses a different technology, targeting different antigens, combining different carriers and adjuvants, and using different immunization schedules. Most of the vaccines are still experimental and not approved by the US or European Regulatory Agencies. In this work, we will offer an update in the knowledge in cancer immunology and all the anticancer vaccine approaches, with special emphasis in ganglioside based vaccines. It has been demonstrated that quantitative and qualitative changes occur in ganglioside expression during the oncogenic transformation. Malignant transformation appears to activate enzymes associated with ganglioside glycosylation, resulting in altered patterns of ganglioside expression in tumors. Direct evidence of the importance of gangliosides as potential targets for active immunotherapy has been suggested by the observation that human monoclonal antibodies against these glycolipids induce shrinkage of human cutaneous melanoma metastasis. Thus, the cellular over-expression and shedding of gangliosides into the interstitial space may play a central role in cell growth regulation, immune tolerance and tumor-angiogenesis, therefore representing a new target for anticancer therapy. Since 1993 researchers at the University of Buenos Aires and the University of Quilmes (Argentina), have taken part in a project carried out by

  14. Contraceptive Vaccines

    Directory of Open Access Journals (Sweden)

    M.V. Supotnitsky

    2014-02-01

    Full Text Available Researches to develop vaccines with contraceptive effect are being carried out since the 1920s. Since 1972, the contraceptive vaccines are one of the priority programs of the World Health Organization (WHO Special Programme of Research, Development and Research Training in Human Reproduction. Rockefeller Foundation participates in implementing the program. Openly declared objective of creating such vaccines — the regulation of the population in the Third World countries. There are currently three main directions of contraceptive vaccine design: 1 vaccines targeted at blocking the production of gametes; 2 impairing their function; 3 violating the fertilization process. Contraceptive vaccines for more than 10 years are widely used to reduce fertility and castration of wild and domestic animals. In the commercial realization there are veterinary vaccines Equity®, Improvac®, GonaCon®, Repro-BLOC (based on gonadotropin-releasing hormone; SpayVac™ and IVT-PZP® (based on zona pellucida antigens. Clinical studies have shown effective contraceptive action (in women of vaccines, in which human chorionic gonadotropin is used as an antigen. At the same time, there are found the side effects of such vaccines: for vaccines containing gonadotropin-releasing hormone and luteinizing hormone as antigenic components — castration, impotence; for vaccines containing follicle stimulating hormone — oligospermia; zona pellucida antigens — irreversible oophoritis. This paper discusses approaches to detection of sterilizing components in vaccines intended for mass prevention of infectious diseases, not reported by manufacturers, and the consequences of their use. Hidden use of contraceptive vaccines, which already took place, can be detected: 1 by the presence of antibodies to their antigenic components (in unvaccinated by contraceptive vaccines people such antibodies do not exist, except infertility cases; 2 by change in the hormonal levels of the

  15. IL28B and IL10R-1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort

    OpenAIRE

    Pár, Alajos; Pár, Gabriella; Tornai, István; Szalay, Ferenc; Várszegi, Dalma; Fráter, Edit; Papp, Mária; Lengyel, Gabriella; Fehér, János; Varga, Márta; Gervain, Judit; Schuller, János; Nemes, Zsuzsanna; Péterfi, Zoltán; Tusnádi, Anna

    2014-01-01

    Background Previous studies have shown that single nucleotide polymorphisms (SNP) in IL28B and IL10R are associated with sustained virological response (SVR) in chronic hepatitis C patients treated with pegilated interferon plus ribavirin (P/R). The present study extends our earlier investigations on a large East-Central European cohort. The allele frequencies of IL28B and IL10R in genotype 1 HCV infection were compared with that of healthy controls for the purpose of examining the relationsh...

  16. Introduction of high-risk medical devices: national measures that can be taken under the current European legislation to put the patient interest central.

    Science.gov (United States)

    Neyt, Mattias; Baeyens, Hanne; Pouppez, Céline; Slegers, Pierre; Hulstaert, Frank; Stordeur, Sabine; Vinck, Irm

    2017-03-01

    High-risk medical devices may not always provide a therapeutic added value to patients. In Europe, no proof of efficacy is required to receive a CE label, making it difficult for policymakers to decide on reimbursement of (often expensive) high-risk medical devices. We explore, within the framework of the European legislation, the possibilities at a national level for a guided introduction of such devices. Areas covered: HTA and legal experts worked in close collaboration with medical specialists and government representatives making a legal analysis of what is possible under the (revised) European and national legislation. Expert commentary: At national level, measures for a better evidence-based introduction can be taken that are not in contradiction with the European regulation. From a legal point of view, all restrictive measures must be justified, necessary and proportional. Several measures are possible, a.o. making use of reference centres, applying the IDEAL framework or the 6-step plan set up by the Dutch Order of Medical Specialists. In conclusion, within the framework of the (revised) European legislation, measures at national level can be taken to temporarily restrict and follow up the use of high-risk medical devices with a greater focus on the therapeutic added value for the patients.

  17. Mandatory and recommended vaccination in the EU, Iceland and Norway: results of the VENICE 2010 survey on the ways of implementing national vaccination programmes.

    Science.gov (United States)

    Haverkate, M; D'Ancona, F; Giambi, C; Johansen, K; Lopalco, P L; Cozza, V; Appelgren, E

    2012-05-31

    This report provides an updated overview of recommended and mandatory vaccinations in the European Union (EU), Iceland and Norway, considering the differences in vaccine programme implementation between countries. In 2010, the Vaccine European New Integrated Collaboration Effort (VENICE) network, conducted a survey among the VENICE project gatekeepers to learn more about how national vaccination programmes are implemented, whether recommended or mandatory. Information was collected from all 27 EU Member States, Iceland and Norway. In total 15 countries do not have any mandatory vaccinations; the remaining 14 have at least one mandatory vaccination included in their programme. Vaccination against polio is mandatory for both children and adults in 12 countries; diphtheria and tetanus vaccination in 11 countries and hepatitis B vaccination in 10 countries. For eight of the 15 vaccines considered, some countries have a mixed strategy of recommended and mandatory vaccinations. Mandatory vaccination may be considered as a way of improving compliance to vaccination programmes. However, compliance with many programmes in Europe is high, using only recommendations. More information about the diversity in vaccine offer at European level may help countries to adapt vaccination strategies based on the experience of other countries. However, any proposal on vaccine strategies should be developed taking into consideration the local context habits.

  18. The YMCA in Central European Countries as One of the Ways of Americanising Central Europe after the First World War (Base of Information and Methodological Approaches zo Researching the Issue

    Directory of Open Access Journals (Sweden)

    Tomáš Tlustý

    2014-07-01

    Full Text Available The YMCA in Central European Countries as One of the Ways of Americanising Central Europe after the First World War (Base of Information and Methodological Approaches zo Researching the Issue The YMCA is essentially an organisation uniting people of Christian faith. The basis of its work was the so-called “Four-way program”, which included religious (spiritual, educational and physical education activities. This organisation was established in London in 1844, having been formed by sales clerk George Williams. The YMCA began to spread rapidly throughout Great Britain. From here it spread to France and subsequently to Holland and Germany. It particularly flourished in the United States of America and came to Czechoslovakia from there after the First World War. Here, the YMCA began to establish military and later student residences. It played an important role in developing basketball, volleyball and other sports. It significantly contributed to the rise of permanent summer camps. It also brought a new view of the world, emerging from American Protestantism. The basic method we have decided to use is the comparative method. Using this classic method of historical research, it is necessary to compare the extent to which the YMCA organisation contributed to the “Americanisation” of national cultures of observed countries and how much it influenced young people. Due to the anticipated inequality and imbalance of sources, the method of probing will have to be used to assess individual regions. Unpublished archive materials as well as magazines and news reports from the period, which have not been systematically researched as yet, will be used as sources of information. YMCA ve středoevropských zemích jako jedna z cest amerikanizace střední Evropy po 1. světové válce (informační báze a metodologické přístupy k řešení problému YMCA je v první řadě organizace sdružující lidi křesťanského vyznání. Základem její pr

  19. FLU VACCINATION

    CERN Multimedia

    2007-01-01

    People working on the CERN site who wish to be vaccinated may go to the Infirmary (ground-floor, bldg. 57), with their vaccine, without a prior appointment. The vaccine can be reimbursed directly by Uniqa providing you attach the receipt and the prescription that you will receive from the Medical Service the day of your injection at the infirmary. Ideally, the vaccination should take place between 1st October and 30th November 2007 (preferably between 14:00 and 16:00). CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor. Medical Service

  20. Rotavirus vaccines.

    Science.gov (United States)

    Lynch, Maureen; Bresee, Joseph S.; Gentsch, Jon R.; Glass, Roger I.

    2000-10-01

    The past few years have seen important developments in understanding the epidemiological and virological characteristics of rotaviruses, and rapid progress has been made in rotavirus vaccine development, but further challenges remain before a vaccine is introduced into widespread use. The licensure of the first rotavirus vaccine, a tetravalent rhesus-based rotavirus vaccine, in the United States in 1998, marked a significant advance in preventing the morbidity associated with rotavirus diarrhea. The association between the tetravalent rhesus-based rotavirus vaccine and intussusception has created significant hurdles as well as new opportunities to study the pathogenesis of rotavirus and rotavirus vaccine infection. Several other rotavirus vaccine candidates are in late stages of development, and results from trials have been encouraging.

  1. Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010

    Directory of Open Access Journals (Sweden)

    Uchtenhagen Hannes

    2011-04-01

    Full Text Available Abstract Novel, exciting intervention strategies to prevent infection with HIV have been tested in the past year, and the field is rapidly evolving. EUROPRISE is a network of excellence sponsored by the European Commission and concerned with a wide range of activities including integrated developmental research on HIV vaccines and microbicides from discovery to early clinical trials. A central and timely theme of the network is the development of the unique concept of co-usage of vaccines and microbicides. This review, prepared by the PhD students of the network captures much of the research ongoing between the partners. The network is in its 5th year and involves over 50 institutions from 13 European countries together with 3 industrial partners; GSK, Novartis and Sanofi-Pasteur. EUROPRISE is involved in 31 separate world-wide trials of Vaccines and Microbicides including 6 in African countries (Tanzania, Mozambique, South Africa, Kenya, Malawi, Rwanda, and is directly supporting clinical trials including MABGEL, a gp140-hsp70 conjugate trial and HIVIS, vaccine trials in Europe and Africa.

  2. Extending recommendations for respiratory vaccines : experimental and non-experimental studies

    NARCIS (Netherlands)

    Jansen, A.G.S.C.

    2007-01-01

    Context: * Many European countries are considering to extend recommendations for influenza vaccination to include otherwise healthy persons aged <65 years. However information about the potential impact of such extension is scarce, particularly for adults. Furthermore, the development of vaccines

  3. Workshop report: Malaria vaccine development in Europe--preparing for the future.

    Science.gov (United States)

    Viebig, Nicola K; D'Alessio, Flavia; Draper, Simon J; Sim, B Kim Lee; Mordmüller, Benjamin; Bowyer, Paul W; Luty, Adrian J F; Jungbluth, Stefan; Chitnis, Chetan E; Hill, Adrian V S; Kremsner, Peter; Craig, Alister G; Kocken, Clemens H M; Leroy, Odile

    2015-11-17

    The deployment of a safe and effective malaria vaccine will be an important tool for the control of malaria and the reduction in malaria deaths. With the launch of the 2030 Malaria Vaccine Technology Roadmap, the malaria community has updated the goals and priorities for the development of such a vaccine and is now paving the way for a second phase of malaria vaccine development. During a workshop in Brussels in November 2014, hosted by the European Vaccine Initiative, key players from the European, North American and African malaria vaccine community discussed European strategies for future malaria vaccine development in the global context. The recommendations of the European malaria community should guide researchers, policy makers and funders of global health research and development in fulfilling the ambitious goals set in the updated Malaria Vaccine Technology Roadmap. Copyright © 2015.

  4. A review of the changes to the licensing of influenza vaccines in Europe.

    Science.gov (United States)

    Wijnans, Leonoor; Voordouw, Bettie

    2016-01-01

    In 2014, the European Committee for Medicinal Products for Human Use (CHMP) published a draft regulatory guideline for the evaluation of influenza vaccines. Following a public consultation round, the final guidance will be published in the near future. Here, we highlight the main changes in the clinical section in this guideline and discuss the background to these changes and whether the new consolidated guidance document can be expected to achieve a better understanding of the performance of seasonal, zoonotic and pandemic influenza vaccines during the regulatory licensing process. The new influenza guideline reflects a changed approach to the regulatory assessment of influenza vaccines, resulting in the abolition of serological criteria, known as the CHMP criteria, which have been the mainstay for evaluating the influenza vaccine immunogenicity for several decades. The new guideline adopts a more diversified approach to the measurement and reporting of the immune response to influenza vaccines and sets a requirement to conduct clinical outcome trials in young children. Importantly, more emphasis is placed on the post-licensure monitoring of the benefit risk of influenza vaccines, including a request for continuous monitoring of efficacy and enhanced safety surveillance. Despite the improvements these new requirements will expectedly bring to the regulatory assessment of influenza vaccines, major challenges remain which cannot be overcome by new guidance alone. Ongoing initiatives in which academia, manufacturers, public health institutes and regulators work together to address these challenges are central to the development of robust tools to evaluate and monitor performance of influenza vaccines in the future. © 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

  5. Vaccines for tick-borne diseases and cost-effectiveness of vaccination: a public health challenge to reduce the diseases’ burden

    OpenAIRE

    Smit, Renata; Postma, Maarten J.

    2016-01-01

    Tick-borne encephalitis (TBE) and Lyme borreliosis (LB) are tick-borne diseases (TBDs), and both present an increasing burden worldwide. Vaccination as public health intervention could be the most effective way to reduce this burden. TBE vaccines are available, but vaccines against LB are still in the phase of development. At the European level, TBE vaccines are likely under-administered to effectively prevent the disease. Cost-effectiveness of vaccination is a helpful tool in the decision ma...

  6. Experience of vaccination with inactivated poliomyelitis vaccines in Iceland.

    Science.gov (United States)

    Gudnadóttir, M

    1981-01-01

    Iceland, as a few other European countries, has used inactivated vaccine against poliomyelitis from the beginning in 1956. No cases of paralytic polio occurred since 1960. For 17 years neither isolations of poliovirus nor suspected cases of the clinical disease have been recorded. Studies on neutralizing antibodies in sera of vaccinees were not too encouraging after 4 injections. A 5th vaccination of IPV was therefore given to those children who lacked antibodies to any type of poliovirus. One month after the 5th injection 70% had antibodies against all 3 types of poliovirus and only 2% lacked antibodies against both types 1 and 3. In countries where no virus to boost immunity exists any longer during the life of an individual it may be necessary to secure booster effects at regular intervals after primary vaccination and later in life. This will be included in the vaccination schedule against polio in Iceland.

  7. National Advisory Groups and their role in immunization policy-making processes in European countries.

    Science.gov (United States)

    Nohynek, H; Wichmann, O; D Ancona, F

    2013-12-01

    During the twenty-first century, the development of national immunization programmes (NIP) has matured into robust processes where evidence-based methodologies and frameworks have increasingly been adopted. A key role in the decision-making and recommending processes is played by National Immunization Technical Advisory Groups (NITAGs). In a survey performed among European Union member states, Norway and Iceland, in February 2013, 85% of the 27 responding countries reported having established a NITAG, and of these, 45% have formal frameworks in place for the systematic development of vaccination recommendations. Independent of whether a formal framework is in place, common key factors are addressed by all NITAGs and also in countries without NITAGs. The four main factors addressed by all were: disease burden in the country, severity of the disease, vaccine effectiveness or efficacy, and vaccine safety at population level. Mathematical modelling and cost-effectiveness analyses are still not common tools. Differences in the relative weighting of these key factors, differences in data or assumptions on country-specific key factors, and differences in existing vaccination systems and financing, are likely to be reasons for differences in NITAG recommendations, and eventually NIPs, across Europe. Even if harmonization of NIPs is presently not a reasonable aim, systematic reviews and the development of mathematical/economic models could be performed at supranational level, thus sharing resources and easing the present work-load of NITAGs. Nevertheless, it has been argued that harmonization would ease central purchase of vaccines, thus reducing the price and increasing access to new vaccines. © 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.

  8. Depleted genetic variation of the European ground squirrel in Central Europe in both microsatellites and the major histocompatibility complex gene: implications for conservation

    Czech Academy of Sciences Publication Activity Database

    Říčanová, Štěpánka; Bryja, Josef; Cosson, J.-F.; Gedeon, C.; Choleva, Lukáš; Ambros, M.; Sedláček, F.

    2011-01-01

    Roč. 12, č. 4 (2011), s. 1115-1129 ISSN 1566-0621 R&D Projects: GA MŠk LC06073 Grant - others:European Science Foundation(XE) ConGen EX/1141 Institutional research plan: CEZ:AV0Z60930519; CEZ:AV0Z50450515 Keywords : Souslik * Endangered species * Habitat fragmentation * DRB * MHC Class II Subject RIV: EG - Zoology Impact factor: 1.610, year: 2011

  9. Vaccine allergies.

    Science.gov (United States)

    Chung, Eun Hee

    2014-01-01

    Currently, the increasing numbers of vaccine administrations are associated with increased reports of adverse vaccine reactions. Whilst the general adverse reactions including allergic reactions caused by the vaccine itself or the vaccine components, are rare, they can in some circumstances be serious and even fatal. In accordance with many IgE-mediated reactions and immediate-type allergic reactions, the primary allergens are proteins. The proteins most often implicated in vaccine allergies are egg and gelatin, with perhaps rare reactions to yeast or latex. Numerous studies have demonstrated that the injectable influenza vaccine can be safely administered, although with appropriate precautions, to patients with severe egg allergy, as the current influenza vaccines contain small trace amounts of egg protein. If an allergy is suspected, an accurate examination followed by algorithms is vital for correct diagnosis, treatment and decision regarding re-vaccination in patients with immediate-type reactions to vaccines. Facilities and health care professionals should be available to treat immediate hypersensitivity reactions (anaphylaxis) in all settings where vaccines are administered.

  10. Status of vaccine research and development of vaccines for malaria.

    Science.gov (United States)

    Birkett, Ashley J

    2016-06-03

    Despite recent progress in reducing deaths attributable to malaria, it continues to claim approximately 500,000 lives per year and is associated with approximately 200 million infections. New tools, including safe and effective vaccines, are needed to ensure that the gains of the last 15 years are leveraged toward achieving the ultimate goal of malaria parasite eradication. In 2015, the European Medicines Agency announced the adoption of a positive opinion for the malaria vaccine candidate most advanced in development, RTS,S/AS01, which provides modest protection against clinical malaria; in early 2016, WHO recommended large-scale pilot implementations of RTS,S in settings of moderate-to-high malaria transmission. In alignment with these advancements, the community goals and preferred product characteristics for next-generation vaccines have been updated to inform the development of vaccines that are highly efficacious in preventing clinical malaria, and those needed to accelerate parasite elimination. Next-generation vaccines, targeting all stages of the parasite lifecycle, are in early-stage development with the most advanced in Phase 2 trials. Importantly, progress is being made in the definition of feasible regulatory pathways to accelerate timelines, including for vaccines designed to interrupt transmission of parasites from humans to mosquitoes. The continued absence of financially lucrative, high-income markets to drive investment in malaria vaccine development points to continued heavy reliance on public and philanthropic funding. Copyright © 2016 World Health Organization. Published by Elsevier Ltd.. All rights reserved.

  11. Universal influenza virus vaccines and therapeutic antibodies.

    Science.gov (United States)

    Nachbagauer, R; Krammer, F

    2017-04-01

    Current influenza virus vaccines are effective when well matched to the circulating strains. Unfortunately, antigenic drift and the high diversity of potential emerging zoonotic and pandemic viruses make it difficult to select the right strains for vaccine production. This problem causes vaccine mismatches, which lead to sharp drops in vaccine effectiveness and long response times to manufacture matched vaccines in case of novel pandemic viruses. To provide an overview of universal influenza virus vaccines and therapeutic antibodies in preclinical and clinical development. PubMed and clinicaltrials.gov were used as sources for this review. Universal influenza virus vaccines that target conserved regions of the influenza virus including the haemagglutinin stalk domain, the ectodomain of the M2 ion channel or the internal matrix and nucleoproteins are in late preclinical and clinical development. These vaccines could confer broad protection against all influenza A and B viruses including drift variants and thereby abolish the need for annual re-formulation and re-administration of influenza virus vaccines. In addition, these novel vaccines would enhance preparedness against emerging influenza virus pandemics. Finally, novel therapeutic antibodies against the same conserved targets are in clinical development and could become valuable tools in the fight against influenza virus infection. Both universal influenza virus vaccines and therapeutic antibodies are potential future options for the control of human influenza infections. Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  12. Differences in pandemic influenza vaccination policies for pregnant women in Europe

    Directory of Open Access Journals (Sweden)

    Marnoch Gordon J

    2011-10-01

    Full Text Available Abstract Background An important component of the policy to deal with the H1N1 pandemic in 2009 was to develop and implement vaccination. Since pregnant women were found to be at particular risk of severe morbidity and mortality, the World Health Organization and the European Centers for Disease Control advised vaccinating pregnant women, regardless of trimester of pregnancy. This study reports a survey of vaccination policies for pregnant women in European countries. Methods Questionnaires were sent to European competent authorities of 27 countries via the European Medicines Agency and to leaders of registries of European Surveillance of Congenital Anomalies in 21 countries. Results Replies were received for 24 out of 32 European countries of which 20 had an official pandemic vaccination policy. These 20 countries all had a policy targeting pregnant women. For two of the four countries without official pandemic vaccination policies, some vaccination of pregnant women took place. In 12 out of 20 countries the policy was to vaccinate only second and third trimester pregnant women and in 8 out of 20 countries the policy was to vaccinate pregnant women regardless of trimester of pregnancy. Seven different vaccines were used for pregnant women, of which four contained adjuvants. Few countries had mechanisms to monitor the number of vaccinations given specifically to pregnant women over time. Vaccination uptake varied. Conclusions Differences in pandemic vaccination policy and practice might relate to variation in perception of vaccine efficacy and safety, operational issues related to vaccine manufacturing and procurement, and vaccination campaign systems. Increased monitoring of pandemic influenza vaccine coverage of pregnant women is recommended to enable evaluation of the vaccine safety in pregnancy and pandemic vaccination campaign effectiveness.

  13. FLU VACCINATION

    CERN Document Server

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical Service

  14. Flu vaccination

    CERN Multimedia

    CERN Medical Service

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor.CERN Medical Service

  15. Flu Vaccination

    CERN Document Server

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical service

  16. Flu Vaccination

    CERN Document Server

    2006-01-01

    People working on the CERN site who wish to be vaccinated against influenza may go to the Medical Service (ground floor, Bldg. 57) without an appointment (preferably between 14:00 and 16:00), PROVIDED THAT THEY BRING THEIR OWN VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. The influenza vaccine is recommended for CERN staff aged 50 and over. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and for those convalescing from serious medical problems or major surgery. The Medical Service will not administer vaccines to family members or retired staff members, who must contact their family doctor. CERN Medical Service

  17. Influenza Vaccine, Live Intranasal

    Science.gov (United States)

    ... influenza vaccine (RIV). The nasal spray flu vaccine (live attenuated influenza vaccine or LAIV) should NOT be ... What is live, attenuated influenza vaccine-LAIV (nasal spray)?A dose of flu vaccine is recommended every flu season. Children younger ...

  18. Central nervous system involvement in mantle cell lymphoma : clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network

    NARCIS (Netherlands)

    Cheah, C. Y.; George, A.; Gine, E.; Chiappella, A.; Kluin-Nelemans, H. C.; Jurczak, W.; Krawczyk, K.; Mocikova, H.; Klener, P.; Salek, D.; Walewski, J.; Szymczyk, M.; Smolej, L.; Auer, R. L.; Ritchie, D. S.; Arcaini, L.; Williams, M. E.; Dreyling, M.; Seymour, J. F.

    Central nervous system (CNS) involvement in mantle cell lymphoma (MCL) is uncommon, and the manifestations and natural history are not well described. We present the data on 57 patients with MCL who developed CNS involvement, from a database of 1396 consecutively treated patients at 14 institutions.

  19. Recommended immunization schedules for adults: Clinical practice guidelines by the Escmid Vaccine Study Group (EVASG), European Geriatric Medicine Society (EUGMS) and the World Association for Infectious Diseases and Immunological Disorders (WAidid).

    Science.gov (United States)

    Esposito, Susanna; Bonanni, Paolo; Maggi, Stefania; Tan, Litjan; Ansaldi, Filippo; Lopalco, Pier Luigi; Dagan, Ron; Michel, Jean-Pierre; van Damme, Pierre; Gaillat, Jacques; Prymula, Roman; Vesikari, Timo; Mussini, Cristina; Frank, Uwe; Osterhaus, Albert; Celentano, Lucia Pastore; Rossi, Marta; Guercio, Valentina; Gavazzi, Gaetan

    2016-07-02

    Rapid population aging has become a major challenge in the industrialized world and progressive aging is a key reason for making improvement in vaccination a cornerstone of public health strategy. An increase in age-related disorders and conditions is likely to be seen in the near future, and these are risk factors for the occurrence of a number of vaccine-preventable diseases. An improvement in infectious diseases prevention specifically aimed at adults and the elderly can therefore also decrease the burden of these chronic conditions by reducing morbidity, disability, hospital admissions, health costs, mortality rates and, perhaps most importantly, by improving the quality of life. Among adults, it is necessary to identify groups at increased risk of vaccine-preventable diseases and highlight the epidemiological impact and benefits of vaccinations using an evidence-based approach. This document provides clinical practice guidance on immunization for adults in order to provide recommendations for decision makers and healthcare workers in Europe. Although immunization is considered one of the most impactful and cost-effective public health measures that can be undertaken, vaccination coverage rates among adults are largely lower than the stated goal of ≥ 95% among adults, and stronger efforts are needed to increase coverage in this population. Active surveillance of adult vaccine-preventable diseases, determining the effectiveness of the vaccines approved for marketing in the last 5 y, the efficacy and safety of vaccines in immunocompromised patients, as well as in pregnant women, represent the priorities for future research.

  20. Oral vaccination of wildlife using a vaccinia-rabies-glycoprotein recombinant virus vaccine (RABORAL V-RG®): a global review.

    Science.gov (United States)

    Maki, Joanne; Guiot, Anne-Laure; Aubert, Michel; Brochier, Bernard; Cliquet, Florence; Hanlon, Cathleen A; King, Roni; Oertli, Ernest H; Rupprecht, Charles E; Schumacher, Caroline; Slate, Dennis; Yakobson, Boris; Wohlers, Anne; Lankau, Emily W

    2017-09-22

    RABORAL V-RG® is an oral rabies vaccine bait that contains an attenuated ("modified-live") recombinant vaccinia virus vector vaccine expressing the rabies virus glycoprotein gene (V-RG). Approximately 250 million doses have been distributed globally since 1987 without any reports of adverse reactions in wildlife or domestic animals since the first licensed recombinant oral rabies vaccine (ORV) was released into the environment to immunize wildlife populations against rabies. V-RG is genetically stable, is not detected in the oral cavity beyond 48 h after ingestion, is not shed by vaccinates into the environment, and has been tested for thermostability under a range of laboratory and field conditions. Safety of V-RG has been evaluated in over 50 vertebrate species, including non-human primates, with no adverse effects observed regardless of route or dose. Immunogenicity and efficacy have been demonstrated under laboratory and field conditions in multiple target species (including fox, raccoon, coyote, skunk, raccoon dog, and jackal). The liquid vaccine is packaged inside edible baits (i.e., RABORAL V-RG, the vaccine-bait product) which are distributed into wildlife habitats for consumption by target species. Field application of RABORAL V-RG has contributed to the elimination of wildlife rabies from three European countries (Belgium, France and Luxembourg) and of the dog/coyote rabies virus variant from the United States of America (USA). An oral rabies vaccination program in west-central Texas has essentially eliminated the gray fox rabies virus variant from Texas with the last case reported in a cow during 2009. A long-term ORV barrier program in the USA using RABORAL V-RG is preventing substantial geographic expansion of the raccoon rabies virus variant. RABORAL V-RG has also been used to control wildlife rabies in Israel for more than a decade. This paper: (1) reviews the development and historical use of RABORAL V-RG; (2) highlights wildlife rabies control

  1. Genetic Diversity of Polymorphic Vaccine Candidate Antigens (Apical Membrane Antigen-1, Merozoite Surface Protein-3, and Erythrocyte Binding Antigen-175) in Plasmodium falciparum Isolates from Western and Central Africa

    Science.gov (United States)

    Soulama, Issiaka; Bigoga, Jude D.; Ndiaye, Magatte; Bougouma, Edith C.; Quagraine, Josephine; Casimiro, Prisca N.; Stedman, Timothy T.; Sirima, Sodiomon B.

    2011-01-01

    The malaria vaccine candidate antigens erythrocyte binding antigen 175 (EBA-175), merozoite surface protein 3 (MSP-3), and apical membrane antigen (AMA-1) from Plasmodium falciparum isolates from countries in central and west Africa were assessed for allelic diversity. Samples were collected on filter paper from 600 P. falciparum-infected symptomatic patients in Cameroon, Republic of Congo, Burkina Faso, Ghana, and Senegal and screened for class-specific amplification fragments. Genetic diversity, assessed by mean heterozygosity, was comparable among countries. We detected a clinical increase in eba 175 F-allele frequency from west to east across the study region. No statistical difference in msp-3 allele distribution between countries was observed. The ama-1 3D7 alleles were present at a lower frequency in central Africa than in West Africa. We also detected little to no genetic differentiation among sampling locations. This finding indicates that, at least at the level of resolution offered by restriction fragment length polymorphism analysis, these antigens showed remarkable genetic homogeneity throughout the region sampled, perhaps caused by balancing selection to maintain a diverse array of antigen haplotyes. PMID:21292899

  2. Public Accountability in the European Union: Is the European Parliament able to hold the European Council accountable?

    Directory of Open Access Journals (Sweden)

    Marianne van de Steeg

    2009-08-01

    Full Text Available The European Council occupies a central role in European politics. Yet it is not officially accountable to any public or parliamentary body for the decisions it makes on behalf of European citizens. National parliaments are only entitled to exert control over their own Heads of Government or State. The European Parliament, as a supranational institution, is the only parliamentary body that regularly discusses European politics with the European Council as a collective, namely via the European Council Presidency. As such, it alone has the possibility to hold the Council accountable for the agreements made at European Summits. However, the European Parliament has limited rights to impose pressure on the European Council Presidency. Nonetheless, despite the lack of a formal accountability arrangement, the European Council Presidency is more forthcoming than could have been expected.

  3. Cancer Vaccines

    Science.gov (United States)

    ... foreign. Most preventive vaccines, including those aimed at cancer-causing viruses ( hepatitis B virus and human papillomavirus ), stimulate the ... 9 through 25 for the prevention of cervical cancer caused by HPV. Hepatitis B virus (HBV) vaccines. Chronic HBV infection can lead to ...

  4. BCG Vaccines.

    Science.gov (United States)

    Tran, Vanessa; Liu, Jun; Behr, Marcel A

    2014-02-01

    BCG is the collective name for a family of live attenuated strains of Mycobacterium bovis that are currently used as the only vaccine against tuberculosis (TB). There are two major reasons for studying the genome of these organisms: (i) Because they are attenuated, BCG vaccines provide a window into Mycobacterium tuberculosis virulence, and (ii) because they have provided protection in several clinical trials and case-control studies, BCG vaccines may shed light on properties required of a TB vaccine. Since the determination of the M. tuberculosis genome in 1998, the study of BCG vaccines has accelerated dramatically, offering data on the genomic differences between virulent M. tuberculosis, M. bovis, and the vaccine strains. While these findings have been rewarding for the study of virulence, there is unfortunately less accrued knowledge about protection. In this chapter, we review briefly the history of BCG vaccines and then touch upon studies over the past two decades that help explain how BCG underwent attenuation, concluding with some more speculative comments as to how these vaccines might offer protection against TB.

  5. VIOLIN: vaccine investigation and online information network.

    Science.gov (United States)

    Xiang, Zuoshuang; Todd, Thomas; Ku, Kim P; Kovacic, Bethany L; Larson, Charles B; Chen, Fang; Hodges, Andrew P; Tian, Yuying; Olenzek, Elizabeth A; Zhao, Boyang; Colby, Lesley A; Rush, Howard G; Gilsdorf, Janet R; Jourdian, George W; He, Yongqun

    2008-01-01

    Vaccines are among the most efficacious and cost-effective tools for reducing morbidity and mortality caused by infectious diseases. The vaccine investigation and online information network (VIOLIN) is a web-based central resource, allowing easy curation, comparison and analysis of vaccine-related research data across various human pathogens (e.g. Haemophilus influenzae, human immunodeficiency virus (HIV) and Plasmodium falciparum) of medical importance and across humans, other natural hosts and laboratory animals. Vaccine-related peer-reviewed literature data have been downloaded into the database from PubMed and are searchable through various literature search programs. Vaccine data are also annotated, edited and submitted to the database through a web-based interactive system that integrates efficient computational literature mining and accurate manual curation. Curated information includes general microbial pathogenesis and host protective immunity, vaccine preparation and characteristics, stimulated host responses after vaccination and protection efficacy after challenge. Vaccine-related pathogen and host genes are also annotated and available for searching through customized BLAST programs. All VIOLIN data are available for download in an eXtensible Markup Language (XML)-based data exchange format. VIOLIN is expected to become a centralized source of vaccine information and to provide investigators in basic and clinical sciences with curated data and bioinformatics tools for vaccine research and development. VIOLIN is publicly available at http://www.violinet.org.

  6. Evaluation of moisture sources for the Central European summer flood of May/June 2013 based on regional climate model simulations

    OpenAIRE

    Kelemen, Fanni D.; Ludwig, Patrick; Reyers, Mark; Ulbrich, Sven; Pinto, Joaquim G.

    2016-01-01

    Heavy precipitation affected Central Europe in May/June 2013, triggering damaging floods both on the Danube and the Elbe rivers. Based on a modelling approach with COSMO-CLM, moisture fluxes, backward trajectories, cyclone tracks and precipitation fields are evaluated for the relevant time period 30 May–2 June 2013. We identify potential moisture sources and quantify their contribution to the flood event focusing on the Danube basin through sensitivity experiments: Control simulations are per...

  7. Genetic architecture is more complex for resistance to Septoria tritici blotch than to Fusarium head blight in Central European winter wheat.

    Science.gov (United States)

    Mirdita, Vilson; Liu, Guozheng; Zhao, Yusheng; Miedaner, Thomas; Longin, C Friedrich H; Gowda, Manje; Mette, Michael Florian; Reif, Jochen C

    2015-06-05

    Fusarium head blight (FHB) and Septoria tritici blotch (STB) severely impair wheat production. With the aim to further elucidate the genetic architecture underlying FHB and STB resistance, we phenotyped 1604 European wheat hybrids and their 135 parental lines for FHB and STB disease severities and determined genotypes at 17,372 single-nucleotide polymorphic loci. Cross-validated association mapping revealed the absence of large effect QTL for both traits. Genomic selection showed a three times higher prediction accuracy for FHB than STB disease severity for test sets largely unrelated to the training sets. Our findings suggest that the genetic architecture is less complex and, hence, can be more properly tackled to perform accurate prediction for FHB than STB disease severity. Consequently, FHB disease severity is an interesting model trait to fine-tune genomic selection models exploiting beyond relatedness also knowledge of the genetic architecture.

  8. [Effect of Pentavac and MMR vaccination on the intestine.].

    Science.gov (United States)

    Thornjóðleifsson, Bjarni; Davíðsdóttir, Katrín; Agnarsson, Ulfur; Theodórs, Arndís; Gunnarsdóttir, Aðalbjœrg; Mœller, Elva; Jónsdóttir, Auður; Sigþórsson, Guðmundur; Kjeld, Matthías; Bjarnason, Ingvar

    2002-06-01

    The safety of infant vaccination has been questioned in recent years. In particular it has been suggested that the measles, mumps and rubella (MMR) vaccination leads to brain damage manifesting as autism consequent to the development of an "enterocolitis" in the immediate post-vaccination period. To assess if MMR vaccination is associated with sub-clinical intestinal inflammation which is central to the autistic "enterocolitis" theory. The study was not designed to test directly the association of autism to MMR vaccination. We studied 109/20 infants, before and two and four weeks after immunization with Pentavac and MMR vaccines, for the presence of intestinal inflammation (faecal calprotectin). Neither vaccination was associated with any significant increase in faecal calprotectin concentrations. The failure of the MMR vaccination to cause an intestinal inflammatory response provides evidence against the proposed gut-brain interaction that is central to the autistic "enterocolitis" hypothesis.

  9. Central European parasitic flatworms of the Cyclocoelidae Stossich, 1902 (Trematoda: Plagiorchiida): molecular and comparative morphological analysis suggests the reclassification of Cyclocoelum obscurum (Leidy, 1887) into the Harrahium Witenberg, 1926.

    Science.gov (United States)

    Sitko, Jiljí; Bizos, Jiří; Heneberg, Petr

    2017-04-01

    Cyclocoelidae Stossich, 1902 are medium-sized to large digenean bird parasites. Although these parasites bear few visible autapomorphic signs, and their diagnostic characters are unstable in response to the pressure applied during preparation, the numerous hitherto suggested re-classifications within the family have not been supported by any molecular analysis. We analyse here cyclocoelids found during the extensive examination of central European birds performed from 1962 to 2016, provide comparative measurements, host spectra, prevalence and intensity, and provide and analyse sequences of four DNA loci of five of the cyclocoelid species. Cyclocoleum Brandes, 1892 appears paraphyletic; thus we suggest the re-classification of Cyclocoleum obscurum (Leidy, 1887) as Harrahium obscurum (Leidy, 1887) Sitko and Heneberg comb. n. Molecular phylogenetics questioned also the validity of Cyclocoelinae Stossich, 1902 and Hyptiasminae Dollfus, 1948, which formed a single clade, whereas Allopyge Johnston, 1913, Prohyptiasmus Witenberg, 1923 and Morishitium Witenberg, 1928 formed another clade. Haematotrephinae Dollfus, 1948 are newly characterized as having a pretesticular or intertesticular ovary that forms a triangle with the testes. Analyses of non-European genera of the Cyclocoelidae and an examination of the position of families within Echinostomata La Rue, 1926 are needed.

  10. The impact of migration on the sexual health, behaviours and attitudes of Central and East European gay/bisexual men in London.

    Science.gov (United States)

    Mole, Richard C M; Parutis, Violetta; Gerry, Christopher J; Burns, Fiona M

    2014-02-01

    Building on an earlier quantitative study which found that gay/bisexual men from Central and Eastern Europe were at greater risk of sexual ill health following migration to the UK, the aim of this qualitative study is to explore how the process of migration itself may have influenced the migrants' sexual behaviour and attitudes. To address these questions, we conducted 17 in-depth interviews in London with gay/bisexual male migrants from Central and Eastern Europe, drawing on Fisher and Fisher's Information-Motivation-Behavioral Skills model as an interpretive framework. We find that the sexual behaviours of our respondents have been significantly influenced by the process of migration itself. In particular, extricating themselves from the traditional systems of social control in their home societies and having greater access to gay venues in London resulted in their increased sexual activity, particularly in the first phase of migration. High-risk sexual behaviour was found to be a factor of sexual mixing, the use of commercial sex and perceptions of risk in the UK vis-á-vis Central and Eastern Europe, with each of these factors also influenced by the process of migration. Risk-prevention behaviour depended upon the possession of appropriate risk-prevention information, motivation to use condoms and appropriate behavioural skills, with the latter two factors in particular influenced by social mores in the home country and the UK. The interviews suggested a number of migration-related factors that increased the STI and HIV risk for these migrants. A number of potentially important policy recommendations stem from our analysis.

  11. Meningococcal Vaccine (For Parents)

    Science.gov (United States)

    ... Educators Search English Español Your Child's Immunizations: Meningococcal Vaccines KidsHealth / For Parents / Your Child's Immunizations: Meningococcal Vaccines Print The meningococcal vaccines protect ...

  12. Increasing influenza vaccination coverage in recommended population groups in Europe.

    Science.gov (United States)

    Blank, Patricia R; Szucs, Thomas D

    2009-04-01

    The clinical and economic burden of seasonal influenza is frequently underestimated. The cornerstone of controlling and preventing influenza is vaccination. National and international guidelines aim to implement immunization programs and targeted vaccination-coverage rates, which should help to enhance the vaccine uptake, especially in the at-risk population. This review purposes to highlight the vaccination guidelines and the actual vaccination situation in four target groups (the elderly, people with underlying chronic conditions, healthcare workers and children) from a European point of view.

  13. Comparative epidemiological study of non-melanoma skin cancer between Spanish and north and central European residents on the Costa del Sol.

    Science.gov (United States)

    Aguilar Bernier, M; Rivas Ruiz, F; De Troya Martín, M; Blázquez Sánchez, N

    2012-01-01

    . Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

  14. Evaluation of moisture sources for the Central European summer flood of May/June 2013 based on regional climate model simulations

    Science.gov (United States)

    Kelemen, Fanni Dora; Ludwig, Patrick; Reyers, Mark; Ulbrich, Sven; Pinto, Joaquim G.

    2016-04-01

    Heavy precipitation affected Central Europe in May/June 2013, triggering damaging floods both on the Danube and the Elbe rivers. A modelling approach with COSMO-CLM is used for a detailed analysis of the evolution of the event. Moisture flux, backward trajectories, evaporation and cyclone track analysis are evaluated for the relevant time period 30 May to 2 June 2013. The aim is to identify potential moisture sources and to quantify their contribution to the flood event in the Danube basin. Control simulations with undisturbed ERA-Interim boundary conditions and sensitivity experiments with modified evaporation characteristics are performed to estimate the role of moisture evaporated from different marine and land areas. The simulated cyclone tracks and upper level flow are compared against reanalysis. Simulated precipitation amounts are validated against E-OBS precipitation data. Two relevant cyclones are identified, which moved counterclockwise in a retrograde path from Southeastern Europe over Eastern Europe towards the northern slopes of the Alps. The control simulations represent the cyclone characteristics and tracks reasonably well. The evolution of the precipitation event in the simulations shows some minor differences to the Reanalysis in terms of its spatial and temporal characteristics. Our sensitivity experiment results provide evidence that the two main sources contributing to the event were the continental evapotranspiration (moisture recycling) and the North Atlantic Ocean. The Mediterranean Sea played only a minor role as a moisture source. This study confirms the importance of continental moisture recycling for heavy precipitation events over Central Europe during the summer half year.

  15. Evaluation of moisture sources for the Central European summer flood of May/June 2013 based on regional climate model simulations

    Directory of Open Access Journals (Sweden)

    Fanni D. Kelemen

    2016-02-01

    Full Text Available Heavy precipitation affected Central Europe in May/June 2013, triggering damaging floods both on the Danube and the Elbe rivers. Based on a modelling approach with COSMO-CLM, moisture fluxes, backward trajectories, cyclone tracks and precipitation fields are evaluated for the relevant time period 30 May–2 June 2013. We identify potential moisture sources and quantify their contribution to the flood event focusing on the Danube basin through sensitivity experiments: Control simulations are performed with undisturbed ERA-Interim boundary conditions, while multiple sensitivity experiments are driven with modified evaporation characteristics over selected marine and land areas. Two relevant cyclones are identified both in reanalysis and in our simulations, which moved counter-clockwise in a retrograde path from Southeastern Europe over Eastern Europe towards the northern slopes of the Alps. The control simulations represent the synoptic evolution of the event reasonably well. The evolution of the precipitation event in the control simulations shows some differences in terms of its spatial and temporal characteristics compared to observations. The main precipitation event can be separated into two phases concerning the moisture sources. Our modelling results provide evidence that the two main sources contributing to the event were the continental evapotranspiration (moisture recycling; both phases and the North Atlantic Ocean (first phase only. The Mediterranean Sea played only a minor role as a moisture source. This study confirms the importance of continental moisture recycling for heavy precipitation events over Central Europe during the summer half year.

  16. Impacts of global change on water-related sectors and society in a trans-boundary central European river basin - Part 1: project framework and impacts on agriculture

    Science.gov (United States)

    Hattermann, F. F.; Gömann, H.; Conradt, T.; Kaltofen, M.; Kreins, P.; Wechsung, F.

    2007-06-01

    Central Europe, the focus region of this study, is a region in transition, climatically from maritime to continental and politically from forme