WorldWideScience

Sample records for centers current understanding

  1. Photosynthetic antennas and reaction centers: Current understanding and prospects for improvement

    Energy Technology Data Exchange (ETDEWEB)

    Blankenship, R.E. [Arizona State Univ., Tempe, AZ (United States)

    1996-09-01

    A brief introduction to the principles, structures and kinetic processes that take place in natural photosynthetic reaction center complexes is presented. Energy is first collected by an antenna system, and is transferred to a reaction center complex where primary electron transfer takes place. Secondary reactions lead to oxidation of water and reduction of CO{sub 2} in some classes of organisms. Antenna systems are highly regulated to maximize energy collection efficiency while avoiding photodamage. Some areas that are presently not well understood are listed.

  2. How to Understand Transplant Center Statistics

    Science.gov (United States)

    ... Print this page How to understand transplant center statistics Because statistics can be hard to understand, we recommend you ... NMDP transplant centers How to understand transplant center statistics Because statistics can be hard to understand, we ...

  3. Current understanding of Pneumocystis immunology

    OpenAIRE

    Kelly, Michelle N; Shellito, Judd E.

    2010-01-01

    Pneumocystis jirovecii is the opportunistic fungal organism that causes Pneumocystis pneumonia (PCP) in humans. Similar to other opportunistic pathogens, Pneumocystis causes disease in individuals who are immunocompromised, particularly those infected with HIV. PCP remains the most common opportunistic infection in patients with AIDS. Incidence has decreased greatly with the advent of HAART. However, an increase in the non-HIV immunocompromised population, noncompliance with current treatment...

  4. Current understanding of the aeronomy of Mars

    Science.gov (United States)

    Nagy, Andrew F.; Grebowsky, Joseph M.

    2015-12-01

    This paper provides a short overview of our current understanding of the upper atmosphere/ionosphere of Mars including the escaping neutral atmosphere to space that plays a key role in the current state of the Mars upper atmosphere. The proper definition of the word "aeronomy" relates to the upper atmosphere where ionization is important. Currently there is a paucity of measurements of the internal physical structure of the Martian upper atmosphere/ionosphere. Much that we know has been deduced from theoretical models that predict many more things than thus far measured. The newest Mars orbital missions, the US MAVEN and Indian MOM missions, just beginning their science analyses, will provide the measurements needed to fully characterize the aeronomy of Mars.

  5. Radiodermatitis: A Review of Our Current Understanding.

    Science.gov (United States)

    Singh, Manni; Alavi, Afsaneh; Wong, Rebecca; Akita, Sadanori

    2016-06-01

    Radiodermatitis (radiation dermatitis, radiation-induced skin reactions, or radiation injury) is a significant side effect of ionizing radiation delivered to the skin during cancer treatment as well as a result of nuclear attacks and disasters, such as that which occurred in Fukushima in 2011. More specifically, 95 % of cancer patients receiving radiation therapy will develop some form of radiodermatitis, including erythema, dry desquamation, and moist desquamation. These radiation skin reactions result in a myriad of complications, including delays in treatment, diminished aesthetic appeal, and reduced quality of life. Recent technological advancements and novel treatment regimens have only been successful in partly ameliorating these adverse side effects. This article examines the current knowledge surrounding the pathogenesis, clinical manifestations, differential diagnoses, prevention, and management of radiodermatitis. Future research should examine therapies that incorporate the current understanding of the pathophysiology of radiodermatitis while measuring effectiveness using objective and universal outcome measures. PMID:27021652

  6. Current understanding of oilsands extraction fundamentals

    Energy Technology Data Exchange (ETDEWEB)

    Masliyah, J.; Xu, Z. [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemical and Materials Engineering

    2006-07-01

    Bitumen production entails bitumen extraction, froth treatment and tailings management. This presentation looked at bitumen extraction with a holistic approach, noting that a basic understanding of extraction is critical to process improvement. Over the past decade, modern characterization techniques have contributed to the progress in understanding the processability of various types of oil sands ores, with recovery ranging from 60 to over 90 per cent. Bitumen recovery involves 3 steps, including bitumen liberation from sand grains, bitumen aeration, and flotation of aerated bitumen. In order to improve bitumen recovery and froth quality, fine solids must be prevented from attaching to bitumen. Water chemistry together with ore characteristics play an important role in determining ore processability. This presentation summarized the progress in understanding and improving oil sands ore processability, made under the Natural Sciences and Engineering Research Council of Canada (NSERC) Oil Sands Industry Research Chair program over the last 5 years. According to zeta potential distribution measurements and colloidal force measurements with atomic force microscope, the oil sands processability depends on the interaction and adhesion forces between fines ores and bitumen in divalent cation solutions. Both bitumen recovery and fines settling in tailings treatment can be enhanced by selective flocculation of fines by anionic polyacrylamide polymer. Single molecular force measurements demonstrate a stronger attachment of the added polymer on clays than on bitumen. Typically, oil sand ores containing hydrophobic fines have poor processability. In terms of water chemistry, the same level of divalent ions in de-ionized water and plant process water does not automatically give the same result in ore processability for a given ore. The existence of surface active components in the plant process water has a considerable impact on the synergistic role of divalent cations and

  7. Current understanding and neurobiology of epileptic encephalopathies.

    Science.gov (United States)

    Auvin, Stéphane; Cilio, Maria Roberta; Vezzani, Annamaria

    2016-08-01

    Epileptic encephalopathies are a group of diseases in which epileptic activity itself contributes to severe cognitive and behavioral impairments above and beyond what might be expected from the underlying pathology alone. These impairments can worsen over time. This concept has been continually redefined since its introduction. A few syndromes are considered epileptic encephalopathies: early myoclonic encephalopathy and Ohtahara syndrome in the neonatal period, epilepsy of infancy with migrating focal seizures, West syndrome or infantile spasms, Dravet syndrome during infancy, Lennox-Gastaut syndrome, epileptic encephalopathy with continuous spikes-and-waves during sleep, and Landau-Kleffner syndrome during childhood. The inappropriate use of this term to refer to all severe epilepsy syndromes with intractable seizures and severe cognitive dysfunction has led to confusion regarding the concept of epileptic encephalopathy. Here, we review our current understanding of those epilepsy syndromes considered to be epileptic encephalopathies. Genetic studies have provided a better knowledge of neonatal and infantile epilepsy syndromes, while neuroimaging studies have shed light on the underlying causes of childhood-onset epileptic encephalopathies such as Lennox-Gastaut syndrome. Apart from infantile spasm models, we lack animal models to explain the neurobiological mechanisms at work in these conditions. Experimental studies suggest that neuroinflammation may be a common neurobiological pathway that contributes to seizure refractoriness and cognitive involvement in the developing brain. PMID:26992889

  8. Cloud networking understanding cloud-based data center networks

    CERN Document Server

    Lee, Gary

    2014-01-01

    Cloud Networking: Understanding Cloud-Based Data Center Networks explains the evolution of established networking technologies into distributed, cloud-based networks. Starting with an overview of cloud technologies, the book explains how cloud data center networks leverage distributed systems for network virtualization, storage networking, and software-defined networking. The author offers insider perspective to key components that make a cloud network possible such as switch fabric technology and data center networking standards. The final chapters look ahead to developments in architectures

  9. Current understanding of multi-species biofilms

    DEFF Research Database (Denmark)

    Yang, Liang; Liu, Yang; Wu, Hong;

    2011-01-01

    Direct observation of a wide range of natural microorganisms has revealed the fact that the majority of microbes persist as surface-attached communities surrounded by matrix materials, called biofilms. Biofilms can be formed by a single bacterial strain. However, most natural biofilms are actually...... formed by multiple bacterial species. Conventional methods for bacterial cleaning, such as applications of antibiotics and/or disinfectants are often ineffective for biofilm populations due to their special physiology and physical matrix barrier. It has been estimated that billions of dollars are spent...... every year worldwide to deal with damage to equipment, contaminations of products, energy losses, and infections in human beings resulted from microbial biofilms. Microorganisms compete, cooperate, and communicate with each other in multi-species biofilms. Understanding the mechanisms of multi...

  10. Current understanding of SEP acceleration and transport

    Science.gov (United States)

    Cohen, C. M. S.

    2016-03-01

    Through new missions and unusual solar conditions, solar cycle 24 has afforded the opportunity for expanding our understanding of solar energetic particle (SEP) acceleration and transport. With complementary SEP observations from multiple spacecraft separated significantly in longitude, it has been possible to examine the longitudinal distribution of energetic particles in individual events, rather than relying on statistical event studies. Unprecedented 360° views of the Sun, in multiple wavelengths and coronagraphs, has made it possible to identify solar source regions regardless of where they are located and to more accurately determine the properties of related coronal mass ejections. The unusually quiet conditions during the onset of cycle 24 allowed smaller SEP events to be examined and their source regions to be unambiguously identified. This paper reviews some of the unexpected results from multi-spacecraft SEP observations made over this solar cycle and discusses their implications for particle acceleration near the Sun and transport through the inner heliosphere.

  11. Between understanding and appreciation. Current science communication in Denmark

    Directory of Open Access Journals (Sweden)

    Kristian Hvidtfelt Nielsen

    2005-12-01

    Full Text Available In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of science. I stress the international aspects of science communication, the national politico-scientific context as well as more local contexts as equally important conditions for understanding current Danish science communication.

  12. Between understanding and appreciation. Current science communication in Denmark

    OpenAIRE

    Kristian Hvidtfelt Nielsen

    2005-01-01

    In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of sci...

  13. Understanding Current Safety Issues for Trajectory Based Operations

    Science.gov (United States)

    Feary, Michael; Stewart, Michael

    2016-01-01

    Increases in procedural complexity were investigated as a possible contributor to flight path deviations in airline operations. Understanding current operational issues and their causes must be embraced to maintain current safety standards while increasing future functionality. ASRS data and expert narratives were used to discover factors relating to pilot deviations. Our investigation pointed to ATC intervention, automation confusion, procedure design, and mixed equipment as primary issues. Future work will need to include objective data and mitigation strategies.

  14. Understanding How Families Use Magnifiers During Nature Center Walks

    Science.gov (United States)

    Zimmerman, Heather Toomey; McClain, Lucy Richardson; Crowl, Michele

    2012-12-01

    This analysis uses a sociocultural learning theory and parent-child interaction framework to understand families' interactions with one type of scientific tool, the magnifier, during nature walks offered by a nature center. Families were video recorded to observe how they organized their activities where they used magnifiers to explore in the outdoors. Findings include that families used magnifiers for scientific inquiry as well as for playful exploration. Using the concept of guided facilitation where families develop roles to support their joint endeavor, three roles to support family thinking were found to be: (a) tool suggester, (b) teacher, and (c) exploration ender. Some families struggled to use magnifiers and often, parents and older siblings provided support for younger children in using magnifying lenses. Implications to informal science learning theory are drawn and suggestions for future family learning research are offered: (a) inclusion of sociocultural and situated perspectives as theories to study informal learning in outdoor spaces, (b) further study on the role of siblings in family interactions, (c) design-based research is needed to encourage family role-taking when engaging in science practices, and (d) new conceptualizations on how to design informal programs that support science learning while leaving space for visitors' personal agendas and interests that can guide the families' activities.

  15. The current understanding on the diamond machining of silicon carbide

    International Nuclear Information System (INIS)

    The Glenn Research Centre of NASA, USA (www.grc.nasa.gov/WWW/SiC/, silicon carbide electronics) is in pursuit of realizing bulk manufacturing of silicon carbide (SiC), specifically by mechanical means. Single point diamond turning (SPDT) technology which employs diamond (the hardest naturally-occurring material realized to date) as a cutting tool to cut a workpiece is a highly productive manufacturing process. However, machining SiC using SPDT is a complex process and, while several experimental and analytical studies presented to date aid in the understanding of several critical processes of machining SiC, the current knowledge on the ductile behaviour of SiC is still sparse. This is due to a number of simultaneously occurring physical phenomena that may take place on multiple length and time scales. For example, nucleation of dislocation can take place at small inclusions that are of a few atoms in size and once nucleated, the interaction of these nucleations can manifest stresses on the micrometre length scales. The understanding of how these stresses manifest during fracture in the brittle range, or dislocations/phase transformations in the ductile range, is crucial to understanding the brittle–ductile transition in SiC. Furthermore, there is a need to incorporate an appropriate simulation-based approach in the manufacturing research on SiC, owing primarily to the number of uncertainties in the current experimental research that includes wear of the cutting tool, poor controllability of the nano-regime machining scale (effective thickness of cut), and coolant effects (interfacial phenomena between the tool, workpiece/chip and coolant), etc. In this review, these two problems are combined together to posit an improved understanding on the current theoretical knowledge on the SPDT of SiC obtained from molecular dynamics simulation. (topical review)

  16. Current Understanding and Therapy of Asthma Workshop Summary

    Institute of Scientific and Technical Information of China (English)

    Kuender D. Yang; Yu-Zhi Chen; Shau-Ku Huang

    2004-01-01

    The prevalence of asthma has increased globally in the past 2 decades. To address this critical issue, a workshop on "Current Understanding and Therapy of Asthma" was recently held in Beijing, as a part of the 10th International Conference of the Society of Chinese Bioscientists in America (SCBA). Several pertinent topics were addressed by leading experts from China, Taiwan, Japan and the US, which include epidemiology, the molecular genetic mechanism, pathogenesis, treatment and prevention of asthma. This article highlights the issues presented and discussed in this ground-breaking symposium emphasizing this important public health problem in the Chinese population. Cellular & Molecular Immunology. 2004;1(6):436-439.

  17. Current Understandings of Spontaneous Isolated Superior Mesenteric Artery Dissection.

    Science.gov (United States)

    Kim, Young-Wook

    2016-06-01

    Spontaneous isolated superior mesenteric artery dissection (SISMAD) has been known as a rare vascular disease. However it is increasingly reported in these days with the development of advanced imaging technology. Underlying etiology, natural course or an optimal management strategy of SISMAD is not exactly known at the moment. During the past 10 years, we have had an interest in this rare vascular disease and collected clinical and image data in 100 or more patients with SISMAD. In this review article, I would like to describe my current understanding of SISMAD on the base of our recent publications in the major vascular surgery journals. PMID:27386450

  18. Current NDT activities at Cekmece Nuclear Research and Training Center

    International Nuclear Information System (INIS)

    Full text: Non-destructive testing (NDT) activities at Cekmece Nuclear Research and Training Center (CNAEM) has been initiated in the Industrial Application Department of the Center which was established in 1976 as the Radioisotope Applications Group for Industry. The Department started its first NDT activity with industrial radiography. The NDT activities have been developed by the support of various national (State Planning Organization (DPT)) and international (IAEA and UNDP) projects. Today, there are five basic NDT techniques (radiography, ultrasonic, magnetic particle, liquid penetrant and eddy current) used in the Industrial Application Department. The Department arranges routinely NDT qualification courses according to ISO 9712 and TS EN 473 standards for level 1 and 2 for Turkish Industry. It also carries out national DPT and IAEA Technical Co-operation projects and gives NDT services in the laboratory and in the field. Digital radiography and digital ultrasonic techniques are being used in advanced NDT applications. This paper describes the NDT activities of CNAEM

  19. Current understanding of organically bound tritium (OBT) in the environment

    International Nuclear Information System (INIS)

    It has become increasingly recognized that organically bound tritium (OBT) is the more significant tritium fraction with respect to understanding tritium behaviour in the environment. There are many different terms associated with OBT; such as total OBT, exchangeable OBT, non-exchangeable OBT, soluble OBT, insoluble OBT, tritiated organics, and buried tritium, etc. A simple classification is required to clarify understanding within the tritium research community. Unlike for tritiated water (HTO), the environmental quantification and behaviour of OBT are not well known. Tritiated water cannot bio-accumulate in the environment. However, it is not clear whether or not this is the case for OBT. Even though OBT can be detected in terrestrial biological materials, aquatic biological materials and soil samples, its behaviour is still in question. In order to evaluate the radiation dose from OBT accurately, further study will be required to understand OBT measurements and determine OBT fate in the environment. The relationship between OBT speciation and the OBT/HTO ratio in environmental samples will be useful in this regard, providing information on the previous tritium exposure conditions in the environment and the current tritium dynamics. -- Highlights: • A new classification for OBT is proposed based on molecular characteristics. • OBT makes up less than 25% of the total tritium dose and can be reduced through food processing. • The OBT/HTO ratio from environmental samples will provide useful information on the previous tritium exposure conditions

  20. Sweetened beverages and health: current state of scientific understandings.

    Science.gov (United States)

    Rippe, James M; Saltzman, Edward

    2013-01-01

    This article summarizes the presentations from the "Sweetened Beverages and Health: Current State of Scientific Understandings" symposium held at the ASN Annual Meeting in Boston, MA on April 23, 2013. The metabolic and health effects of sugar-sweetened beverages were discussed from a variety of points of view by 5 different presenters. Dr. David Allison drew a distinction between conjecture and proof related to sweetened beverages and obesity. Dr. Richard Mattes discussed differences between solid and liquid calories. Dr. Miguel Alonso-Alonso reviewed potential contributions of functional neuroimaging, particularly as they relate to whether sugar is potentially "addictive." Dr. Kimber Stanhope discussed work related to experiments comparing fructose to glucose. Dr. James Rippe presented evidence from randomized controlled trials from his research organization showing no differences among high-fructose corn syrup, sucrose, glucose, or fructose at normal human consumption amounts. PMID:24038246

  1. Understanding and improving inpatient mortality in academic medical centers.

    Science.gov (United States)

    Behal, Raj; Finn, Jeannine

    2009-12-01

    The purpose of this article is to describe factors contributing to potentially preventable mortality in academic medical centers and the organizational characteristics associated with success in reducing mortality. Sixteen U.S. academic medical centers that wished to improve risk-adjusted inpatient mortality rates requested a consultation that included interviews with physicians, nurses, and hospital leaders; review of medical records; and evaluation of systems and processes of care. The assessments took place on-site; they identified key factors contributing to preventable mortality, and each hospital received specific recommendations. Changes in observed mortality and in the ratio of observed to expected mortality were measured from 2002 to final follow-up in 2007. Evaluations determined each hospital's success factors and key barriers to improvement. The key factors contributing to preventable mortality were delays in responding to deteriorating patients, suboptimal critical care, hospital-acquired infections, postoperative complications, medical errors, and community issues such as the availability of hospice care. Of the 16 hospitals, 12 were able to reduce their mortality index. The five hospitals that had the greatest improvement in mortality were the only hospitals with a broad level of engagement among hospital and physician leaders, including the department chairs. In the hospitals whose performance did not improve, the department chairs were not engaged in the process. The academic medical centers that focused on mortality reduction and had engagement of physicians, especially department chairs, were able to achieve meaningful reductions in hospital mortality. The necessary ingredients for achieving meaningful improvement in clinical outcomes included good data, a sound method for change, and physician leadership. PMID:19940569

  2. Pressure ulcers: Current understanding and newer modalities of treatment

    Directory of Open Access Journals (Sweden)

    Surajit Bhattacharya

    2015-01-01

    Full Text Available This article reviews the mechanism, symptoms, causes, severity, diagnosis, prevention and present recommendations for surgical as well as non-surgical management of pressure ulcers. Particular focus has been placed on the current understandings and the newer modalities for the treatment of pressure ulcers. The paper also covers the role of nutrition and pressure-release devices such as cushions and mattresses as a part of the treatment algorithm for preventing and quick healing process of these wounds. Pressure ulcers develop primarily from pressure and shear; are progressive in nature and most frequently found in bedridden, chair bound or immobile people. They often develop in people who have been hospitalised for a long time generally for a different problem and increase the overall time as well as cost of hospitalisation that have detrimental effects on patient′s quality of life. Loss of sensation compounds the problem manifold, and failure of reactive hyperaemia cycle of the pressure prone area remains the most important aetiopathology. Pressure ulcers are largely preventable in nature, and their management depends on their severity. The available literature about severity of pressure ulcers, their classification and medical care protocols have been described in this paper. The present treatment options include various approaches of cleaning the wound, debridement, optimised dressings, role of antibiotics and reconstructive surgery. The newer treatment options such as negative pressure wound therapy, hyperbaric oxygen therapy, cell therapy have been discussed, and the advantages and disadvantages of current and newer methods have also been described.

  3. Treatment Perspectives Based on Our Current Understanding of Concussion.

    Science.gov (United States)

    Gay, Michael

    2016-09-01

    Sports-related concussion also referred to in the literature as mild traumatic brain injury remains a popular area of study for physicians, neurologists, neuropsychologists, neuroimaging, athletic trainers, and researchers across the other areas of brain sciences. Treatment for concussion is an emerging area of focus with investigators seeking to improve outcomes and protect patients from the deleterious short-term and long-term consequences which have been extensively studied and identified. Broadly, current treatment strategies for athletes recovering from concussion have remained largely unchanged since early 2000s. Knowledge of the complex pathophysiology surrounding injury should improve or advance our ability to identify processes which may serve as targets for therapeutic intervention. Clinicians working with athletes recovering from sports-related concussion should have an advanced understanding of the injury cascade and also be aware of the current efforts within the research to treat concussion. In addition, how clinicians use the word "treatment" should be carefully defined and promoted so the patient is aware of the level of intervention and what stage of recovery or healing is being affected by a specific intervention. The purpose of this review is to bring together efforts across disciplines of brain science into 1 platform where clinicians can assimilate this information before making best practices decisions regarding the treatment of patients and athletes under their care. PMID:27482780

  4. Ambulatory surgery centers--current legal issues 2004 (Part 2).

    Science.gov (United States)

    Becker, Scott; Szabad, Melissa; Foltushansky, Sofia

    2004-05-01

    component of the procedure performed with the equipment, and the vendor then pays the ASC a fee for its lease of ASC space to house the equipment. These types of relationships can raise several legal compliance concerns. An ASC should understand that the arrangement could jeopardize its state ASC license and its Medicare certification even though the arrangement does not involve Medicare certified procedures or Medicare patients. Furthermore, this type of business venture might not comply with state and federal self referral laws. ASCs are also increasingly facing situations where a provider performs a procedure for which there is no facility charge for the ASC, but the physician is receiving a professional fee from Medicare. In this situation, ASCs should implement a policy, similar to the example provided in this article, to avoid even the appearance of providing an inducement or reward for referrals of Medicare or Medicaid business by requiring physicians to pay the Center a fee, consistent with fair market value, for the use of the Center for non-Covered Procedures or for performing multiple procedures within the same operative session. Lastly, as touched upon by this article, in the joint venture context, ASCs must take into account several guidelines in order to steer clear from risks associated with tax-exempt entities as an investor and antitrust price fixing issues. Whether a joint venture, of which a tax exempt entity is an investor, is deemed organized and operated in furtherance of the charitable purposes of a tax-exempt partner as set forth in Section 501(c)(3) of the Code depends on the facts and circumstances of each case. Generally, a joint venture will satisfy the guidelines if the tax-exempt investor in the joint venture retains sufficient control over the joint venture to ensure that the joint venture furthers the charitable purposes of the tax-exempt investor and adequately serves the community. In the ASC physician hospital joint venture arena, the

  5. Spinal pain: current understanding, trends, and the future of care

    Directory of Open Access Journals (Sweden)

    Parkin-Smith GF

    2015-10-01

    Full Text Available Gregory F Parkin-Smith,1 Lyndon G Amorin-Woods,2–4 Stephanie J Davies,5–7 Barrett E Losco,8 Jon Adams9,10 1General Practice, Surgery 82, Busselton, WA, Australia; 2School of Health Professions, Murdoch University, Murdoch, WA, Australia; 3Chiropractors’ Association of Australia, Nedlands, WA, Australia; 4ACORN Project, 5WA Specialist Pain Services, WA, Australia; 6School of Physiotherapy, Curtin University, Bentley, WA, Australia; 7School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; 8Murdoch University, Murdoch, WA, Australia; 9Faculty of Health, University of Technology Sydney, Ultimo, NSW, Australia; 10Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, Australia Abstract: This commissioned review paper offers a summary of our current understanding of nonmalignant spinal pain, particularly persistent pain. Spinal pain can be a complex problem, requiring management that addresses both the physical and psychosocial components of the pain experience. We propose a model of care that includes the necessary components of care services that would address the multidimensional nature of spinal pain. Emerging care services that tailor care to the individual person with pain seems to achieve better outcomes and greater consumer satisfaction with care, while most likely containing costs. However, we recommend that any model of care and care framework should be developed on the basis of a multidisciplinary approach to care, with the scaffold being the principles of evidence-based practice. Importantly, we propose that any care services recommended in new models or frameworks be matched with available resources and services – this matching we promote as the fourth principle of evidence-based practice. Ongoing research will be necessary to offer insight into clinical outcomes of complex interventions, while practice-based research would uncover

  6. Modelling Monsoons: Understanding and Predicting Current and Future Behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Turner, A; Sperber, K R; Slingo, J M; Meehl, G A; Mechoso, C R; Kimoto, M; Giannini, A

    2008-09-16

    including, but not limited to, the Mei-Yu/Baiu sudden onset and withdrawal, low-level jet orientation and variability, and orographic forced rainfall. Under anthropogenic climate change many competing factors complicate making robust projections of monsoon changes. Without aerosol effects, increased land-sea temperature contrast suggests strengthened monsoon circulation due to climate change. However, increased aerosol emissions will reflect more solar radiation back to space, which may temper or even reduce the strength of monsoon circulations compared to the present day. A more comprehensive assessment is needed of the impact of black carbon aerosols, which may modulate that of other anthropogenic greenhouse gases. Precipitation may behave independently from the circulation under warming conditions in which an increased atmospheric moisture loading, based purely on thermodynamic considerations, could result in increased monsoon rainfall under climate change. The challenge to improve model parameterizations and include more complex processes and feedbacks pushes computing resources to their limit, thus requiring continuous upgrades of computational infrastructure to ensure progress in understanding and predicting the current and future behavior of monsoons.

  7. Antibody Affinity Maturation in Fishes—Our Current Understanding

    Science.gov (United States)

    Magor, Brad G.

    2015-01-01

    It has long been believed that fish lack antibody affinity maturation, in part because they were thought to lack germinal centers. Recent research done on sharks and bony fishes indicates that these early vertebrates are able to affinity mature their antibodies. This article reviews the functionality of the fish homologue of the immunoglobulin (Ig) mutator enzyme activation-induced cytidine deaminase (AID). We also consider the protein and molecular evidence for Ig somatic hypermutation and antibody affinity maturation. In the context of recent evidence for a putative proto-germinal center in fishes we propose some possible reasons that observed affinity maturation in fishes often seems lacking and propose future work that might shed further light on this process in fishes. PMID:26264036

  8. Antibody Affinity Maturation in Fishes-Our Current Understanding.

    Science.gov (United States)

    Magor, Brad G

    2015-01-01

    It has long been believed that fish lack antibody affinity maturation, in part because they were thought to lack germinal centers. Recent research done on sharks and bony fishes indicates that these early vertebrates are able to affinity mature their antibodies. This article reviews the functionality of the fish homologue of the immunoglobulin (Ig) mutator enzyme activation-induced cytidine deaminase (AID). We also consider the protein and molecular evidence for Ig somatic hypermutation and antibody affinity maturation. In the context of recent evidence for a putative proto-germinal center in fishes we propose some possible reasons that observed affinity maturation in fishes often seems lacking and propose future work that might shed further light on this process in fishes. PMID:26264036

  9. Current understanding of the sequence of events. Overview of current understanding of accident progression at Fukushima Dai-ichi

    International Nuclear Information System (INIS)

    An overview of the main sequence of events, particularly the evolution of the cores in Units 1-3 was given. The presentation is based on information provided by Dr Okajima of JAEA to the June 2012 Nuclear Science Committee meeting. During the accident, conditions at the plant were such that operators were initially unable to obtain instruments readouts from the control panel and hence could not know what condition the reactors were in. (Reactor Power, Pressure, Temperature, Water height and flow rate, etc.). Subsequently, as electrical power supplies were gradually restored more data became available. In addition to the reactor data, other information from off-site measurements and from measuring stations inside the site boundary is now available, particularly for radiation dose rates in air. These types of information, combined with detailed knowledge of the plant design and operations history up to the time of the accident are being used to construct detailed computer models which simulate the behaviour of the reactor core, pressure vessel and containment during the accident sequence. This combination of detailed design/operating data, limited measured data during the accident and computer modelling allows us to construct a fairly clear picture of the accident progression. The main sequence of events (common to Units 1, 2 and 3) is summarised. The OECD/NEA is currently coordinating an international benchmark study of the accident at Fukushima Daiichi known as the BSAF Project. The objectives of this activity are to analyse and evaluate the accident progression and improve severe accident (SA) analysis methods and models. The project provides valuable additional (and corrected) data from plant measurements as well as an improved understanding of the role played by the fuel and cladding design. Based on (limited) plant data and extensive modelling analysis, we have a detailed qualitative description of the Fukushima-Daiichi accident. Further analyses of the type

  10. The current state of public understanding of nanotechnology

    International Nuclear Information System (INIS)

    The growing importance of nanotechnology in industry and society has not been accompanied by a widespread understanding of the subject among the general public. Simple questions to initially probe the smallest thing that people can see and can think of reveals a divide in the understanding of the general public. A survey of 1500 individuals ranging in age from 6 to 74 has revealed a lack of knowledge of nanotechnology and especially a lack of understanding of the context of nanotechnology in the world that is too small to see. Survey findings are corroborated by in-depth interviews with 400 adults in studies of nanoscience literacy commisioned by University of California, Berkeley and Cornell in 2002 and 2004, respectively. In general, with the exception of 14-28 year olds, over 60% of respondents say they have never heard of nano or nanotechnology. The results suggest that the general public, especially middle-school children, has no firm foundation to understand nanotechnology and likely will continue to be equally impressed by credible scientific information as well as pure fictional accounts of nanotechnology

  11. From product centered design to value centered design: understanding the value-system

    DEFF Research Database (Denmark)

    Randmaa, Merili; Howard, Thomas J.; Otto, T.

    more value for the customer for less eford. Value and understanding the value-system needs to be in the focus of business strategy. Value can be created, exchanged and perceived. It can be tangible (physical products, money) or intangible (information, experience, relationships, service). Creating......Product design has focused on different parameters through history- design for usability, design for manufacturing, design for assembly etc. Today, as the products get bundled with service, it is important to interconnect product, service and business model design to create synergy effect and offer...... value is usually a co-creation process, where customers, suppliers and manufacturers all have their part. This paper describes a paradigm shift towards value-based thinking and proposes a new methodology for understanding and analysing the value system....

  12. Students' Understanding of Direct Current Resistive Electrical Circuits

    CERN Document Server

    Engelhardt, P V; Engelhardt, Paula V.; Beichner, Robert J.

    2003-01-01

    Research has shown that both high school and university students' reasoning patterns regarding direct current resistive electric circuits often differ from the currently accepted explanations. At present, there are no standard diagnostic examinations in electric circuits. Two versions of a diagnostic instrument called Determining and Interpreting Resistive Electric circuits Concepts Tests (DIRECT) were developed, each consisting of 29 questions. The information provided by the exam provides classroom instructors a means with which to evaluate the progress and conceptual difficulties of their students and their instructional methods. It can be used to evaluate curricular packages and/or other supplemental materials for their effectiveness in overcoming students' conceptual difficulties. The analyses indicate that students, especially females, tend to hold multiple misconceptions, even after instruction. During interviews, the idea that the battery is a constant source of current was used most often in answerin...

  13. Myocardial Viability and Revascularization: Current Understanding and Future Directions.

    Science.gov (United States)

    Patel, Pavan; Ivanov, Alexander; Ramasubbu, Kumudha

    2016-06-01

    The initial observation of functional recovery in dysfunctional myocardium following revascularization led to the introduction of the concept of hibernating myocardium. Since then, the pathophysiologic basis of hibernating myocardium has been well described. Multiple imaging modalities have been utilized to prospectively detect viable myocardium and thus predict its functional recovery following revascularization. It has been hypothesized that viability imaging will be instrumental in the selection of patients with ischemic cardiomyopathy likely to benefit from revascularization. Multiple observational studies built a large body of evidence supporting this concept. However, data from prospective studies failed to substantiate utility of viability testing. This review aims to summarize the current literature and describe the role of viability imaging in current clinical practice as well as future directions. PMID:27115143

  14. Current understanding of the neuropathophysiology of pain in chronic pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Amporn; Atsawarungruangkit; Supot; Pongprasobchai

    2015-01-01

    Chronic pancreatitis(CP) is a chronic inflammatory disease of the pancreas. The main symptom of patients with CP is chronic and severe abdominal pain. However, the pathophysiology of pain in CP remains obscure.Traditionally, researchers believed that the pain was caused by anatomical changes in pancreatic structure. However, treatment outcomes based on such beliefs are considered unsatisfactory. The emerging explanations of pain in CP are trending toward neurobiological theories. This article aims to review current evidence regarding the neuropathophysiology of pain in CP and its potential implications for the development of new treatments for pain in CP.

  15. The Vaginal Microbiome: Current Understanding and Future Directions.

    Science.gov (United States)

    Martin, David H; Marrazzo, Jeanne M

    2016-08-15

    This article summarizes the highlights of the expert technical consultation on bacterial vaginosis (BV), sponsored by the National Institute of Allergy and Infectious Disease and held in Washington, DC, on 8-9 April 2015. Many issues touched on in this article are discussed in much greater detail in the 6 preceding articles in this supplement to The Journal of Infectious Diseases There was a consensus among the meeting attendees concerning the most important research issues in the field: the pathogenesis of the syndrome, way to optimize treatment, and the relative roles of sexual transmission and endogenous infection in BV epidemiology. This article concludes with a listing of BV and genitourinary tract research priorities that were discussed and agreed on by attendees. The most important of these included better characterization of vaginal microbiome community state subtypes, application of advanced "-omic" technologies to improve understanding of BV pathogenesis, further investigation of the relationships between the male and female genitourinary tract microbiomes, and the development of new drugs for BV treatment. PMID:27449871

  16. Current challenges with understanding greigite (Fe3S4) magnetism

    Science.gov (United States)

    Chang, L.; Roberts, A. P.; Winklhofer, M.; Vasiliev, I.; Dekkers, M. J.; Krijgsman, W.

    2014-12-01

    Greigite (Fe3S4) is a widespread authigenic magnetic mineral in anoxic sediments, and is also commonly biosynthesized by magnetotactic bacteria in aqueous environments. Despite the importance of greigite in paleomagnetic and environmental magnetic studies, knowledge of its magnetic properties is at a much lower level than for more common rock-forming magnetic minerals. Much recent progress has been made to develop a more complete understanding of the magnetic properties of greigite and the range of grain sizes in which greigite occurs in nature. We present results of new determinations of a range of fundamental magnetic properties of greigite, including the saturation magnetization, the magnetocrystalline anisotropy, and calculated rock magnetic properties. In addition, we provide evidence for the preservation of greigite magnetofossils in ancient sediments, which has important implications for assessing the reliability of paleomagnetic records carried by greigite. Finally, we present an integrated study from a Messinian former Black Sea sedimentary sequence to unravel environmental controls on diagenetic greigite formation, and demonstrates the usefulness of greigite for studying long-term climate variability in anoxic environments.

  17. The autophagosome: current understanding of formation and maturation

    Directory of Open Access Journals (Sweden)

    Mannack LVJC

    2015-02-01

    Full Text Available Lilith VJC Mannack, Jon D Lane Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK Abstract: Autophagy is an important and highly conserved catabolic process with roles in development, homeostasis, and cellular stress responses. It describes various distinct pathways for the delivery of cytoplasmic materials (including misfolded protein aggregates and some organelles to the lysosome for degradation and component recycling. The best understood form of autophagy (macroautophagy describes the de novo assembly, maturation, and trafficking of a unique double membrane-bound organelle – the autophagosomes – that sequesters cytoplasmic materials and ultimately merges with the lysosomal compartment to form a degradative autolysosome. To rapidly assemble such a structure in response to stimuli, cells express a family of dedicated autophagy-related (ATG gene products that act sequentially to control membrane events leading first to the nucleation of an isolation membrane or phagophore, followed by phagophore expansion, and sealing to form an autophagosome that traffics to – and ultimately fuses with – the lysosome. These molecules are activated in response to upstream signaling pathways (notably, the mechanistic target of rapamycin [mTOR] pathway, and comprise protein and lipid kinases, putative membrane coats, and unique ubiquitin-like conjugation systems. In concert, a barrage of accessory proteins involved in various membrane trafficking pathways focused on the endosomal compartment are co-opted at the assembly site to facilitate autophagosome biogenesis. Understanding the integrated pathways that coordinate autophagosome assembly at the molecular level will be crucial if we are to realize the potential for autophagy manipulation in future disease therapies. Keywords: autophagy, ATG proteins, lysosome, phagophore, omegasome, autolysosome, membrane trafficking, ULK1, mTOR, PI(3 kinase, PI3P, LIR motif

  18. Understanding Material Property Impacts on Co-Current Flame Spread: Improving Understanding Crucial for Fire Safety

    Science.gov (United States)

    Ruff, Gary (Technical Monitor); Rangwala, Ali S.; Buckley, Steven G.; Torero, Jose L.

    2004-01-01

    The prospect of long-term manned space flight brings fresh urgency to the development of an integrated and fundamental approach to the study of material flammability. Currently, NASA uses two tests, the upward flame propagation test and heat and visible smoke release rate test, to assess the flammability properties of materials to be used in space under microgravity conditions. The upward flame propagation test can be considered in the context of the 2-D analysis of Emmons. This solution incorporates material properties by a "mass transfer number", B in the boundary conditions.

  19. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities

    Science.gov (United States)

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  20. Current Development at the Southern California Earthquake Data Center (SCEDC)

    Science.gov (United States)

    Appel, V. L.; Clayton, R. W.

    2005-12-01

    Over the past year, the SCEDC completed or is near completion of three featured projects: Station Information System (SIS) Development: The SIS will provide users with an interface into complete and accurate station metadata for all current and historic data at the SCEDC. The goal of this project is to develop a system that can interact with a single database source to enter, update and retrieve station metadata easily and efficiently. The system will provide accurate station/channel information for active stations to the SCSN real-time processing system, as will as station/channel information for stations that have parametric data at the SCEDC i.e., for users retrieving data via STP. Additionally, the SIS will supply information required to generate dataless SEED and COSMOS V0 volumes and allow stations to be added to the system with a minimum, but incomplete set of information using predefined defaults that can be easily updated as more information becomes available. Finally, the system will facilitate statewide metadata exchange for both real-time processing and provide a common approach to CISN historic station metadata. Moment Tensor Solutions: The SCEDC is currently archiving and delivering Moment Magnitudes and Moment Tensor Solutions (MTS) produced by the SCSN in real-time and post-processing solutions for events spanning back to 1999. The automatic MTS runs on all local events with magnitudes > 3.0, and all regional events > 3.5. The distributed solution automatically creates links from all USGS Simpson Maps to a text e-mail summary solution, creates a .gif image of the solution, and updates the moment tensor database tables at the SCEDC. Searchable Scanned Waveforms Site: The Caltech Seismological Lab has made available 12,223 scanned images of pre-digital analog recordings of major earthquakes recorded in Southern California between 1962 and 1992 at http://www.data.scec.org/research/scans/. The SCEDC has developed a searchable web interface that allows

  1. Understandings of Current Environmental Issues: Turkish Case Study in Six Teacher Education Colleges

    Science.gov (United States)

    Cakir, Mustafa; Irez, Serhat; Dogan, Ozgur Kivilcan

    2010-01-01

    The purpose of this study is to profile future science teachers' understandings of current environmental issues in the context of an education reform in Turkey. Knowledge base and understandings of elementary and secondary prospective science teachers about biodiversity, carbon cycle, global warming and ozone layer depletion were targeted in the…

  2. Complete classification of simple current modular invariants for RCFT's with a center (Zp)k

    International Nuclear Information System (INIS)

    Simple currents have been used previously to construct various examples of modular invariant partition functions for given rational conformal field theories. In this paper we present for a large class of such theories (namely those with a center that decomposes into factors Zp, p prime) the complete set of modular invariants that can be obtained with simple currents. In addition to the fusion rule automorphisms classified previously for any center, this includes all possible left-right combinations of all possible extensions of the chiral algebra that can be obtained with simple currents, for all possible current-current monodromies. Formulas for the number of invariants of each kind are derived. Although the number of invariants in each of these subsets depends on the current-current monodromies, the total number of invariants depends rather surprisingly only on p and the number of Zp factors. (orig.)

  3. Complete classification of simple current modular invariants for RCFT's with a center (Z p ) k

    Science.gov (United States)

    Gato-Rivera, B.; Schellekens, A. N.

    1992-03-01

    Simple currents have been used previously to construct various examples of modular invariant partition functions for given rational conformal field theories. In this paper we present for a large class of such theories (namely those with a center that decomposes into factors Z p , p prime) the complete set of modular invariants that can be obtained with simple currents. In addition to the fusion rule automorphisms classified previously for any center, this includes all possible left-right combinations of all possible extensions of the chiral algebra that can be obtained with simple currents, for all possible current-current monodromies. Formulas for the number of invariants of each kind are derived. Although the number of invariants in each of these subsets depends on the current-current monodromies, the total number of invariants depends rather surprisingly only on p and the number of Z p factors.

  4. Godzilla Mullion: current understanding on the nature of the world’s largest oceanic core complex

    Science.gov (United States)

    Ohara, Y.; Snow, J. E.

    2009-12-01

    Oceanic core complex (OCC) provides a valuable opportunity to directly study the architecture of oceanic lithosphere, together with the tectono-magmatic processes that were associated with its formation and evolution. The world’s largest OCC, Godzilla Mullion, occurs along the Parece Vela Rift, extinct spreading center of the Parece Vela Basin in the Philippine Sea. Backarc basins are not in some way anomalous, but are in fact generating a significant fraction of the total oceanic crust. Therefore, the opportunity to explore the architecture of Godzilla Mullion is an important contribution to the overall understanding of oceanic lithosphere. In order to understand the different processes of OCC formation and the composition of the backarc mantle, and to provide a comparison of present day backarc mantle useful for the study of ophiolitic lower crustal and mantle sequences, we have conducted a series of cruises to the area in the last decade. In 2009, during YK09-05 cruise of R/V Yokosuka, we performed successful 9 dives of Shinkai 6500 and 3 dives of deep-towed camera, resulting in 12 new sample locations on the surface of Godzilla Mullion. The number of sample locations on the surface of Godzilla Mullion is now 36 different locations in total. Before YK09-05 cruise, we used a single name of “Godzilla Mullion” for its description. However, now that we have 36 sample locations, it has become difficult to describe the very enormous OCC with a single name. We thus have given 13 different names to the distinct topographic elements of Godzilla Mullion. In this contribution, we will introduce our current understanding of the nature of Godzilla Mullion, summarizing the recent results of geological mapping and its comparison with seismic tomography model. Godzilla Mullion has large lateral heterogeneity in the crust, varying from the region dominated with mantle peridotite overlain by a carapace of diabase and basalt, to the region with a massive gabbroic section

  5. Between understanding and appreciation. Current science communication in Denmark (Danish original version

    Directory of Open Access Journals (Sweden)

    Kristian Hvidtfelt Nielsen

    2005-12-01

    Full Text Available In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of science. I stress the international aspects of science communication, the national politico-scientific context as well as more local contexts as equally important conditions for understanding current Danish science communication.

  6. Understanding the Occurrence and Transport of Current-use Pesticides in the San Francisco Estuary Watershed

    OpenAIRE

    Kuivila, Kathryn; Hladik, Michelle

    2008-01-01

    The occurrence and potential effects of current-use pesticides are of concern in the San Francisco Estuary watershed but our understanding of the spatial and temporal distribution of contamination is limited. This paper summarizes almost two decades of historical data and uses it to describe our current knowledge of the processes controlling the occurrence of current-use pesticides in the watershed. Monitoring studies analyze fewer than half of the pesticides applied in the watershed and most...

  7. Using Learner-Centered Strategies to Improve Student Understanding About Stars

    Science.gov (United States)

    Bailey, Janelle M.; Nagamine, K.

    2009-01-01

    As faculty increasingly adopt learner-centered strategies for their introductory astronomy classes, it is important to determine whether such strategies are positively impacting student learning. One measure of student achievement that has been adopted is the use of concept inventories to measure changes in understanding of a specific topic over some period of instruction. The Star Properties Concept Inventory (SPCI) was used as a pre/posttest in a lecture-only course during Spring 2007 and again in Fall 2007 when the instructors incorporated Peer Instruction-style questions and Lecture Tutorials. Initial analysis shows that although pretest results were not significantly different between the two semesters, posttest results for the Fall 2007 semester are statistically significantly higher than those of the Spring 2007 offering. This result supports the idea that learner-centered strategies are more effective at supporting student understanding than are traditional lecture-only methods. This project is supported by the University of Nevada, Las Vegas Division of Research and Graduate Studies.

  8. Between understanding and appreciation. Current science communication in Denmark (Danish original version)

    OpenAIRE

    Kristian Hvidtfelt Nielsen

    2005-01-01

    In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of sci...

  9. Fuel-coolant interaction (FCI) phenomena in reactor safety. Current understanding and future research needs

    Energy Technology Data Exchange (ETDEWEB)

    Speis, T.P. [Maryland Univ., College Park, MD (United States); Basu, S.

    1998-01-01

    This paper gives an account of the current understanding of fuel-coolant interaction (FCI) phenomena in the context of reactor safety. With increased emphasis on accident management and with emerging in-vessel core melt retention strategies for advanced light water reactor (ALWR) designs, recent interest in FCI has broadened to include an evaluation of potential threats to the integrity of reactor vessel lower head and ex-vessel structural support, as well as the role of FCI in debris quenching and coolability. The current understanding of FCI with regard to these issues is discussed, and future research needs to address the issues from a risk perspective are identified. (author)

  10. Fuel-coolant interaction (FCI) phenomena in reactor safety. Current understanding and future research needs

    International Nuclear Information System (INIS)

    This paper gives an account of the current understanding of fuel-coolant interaction (FCI) phenomena in the context of reactor safety. With increased emphasis on accident management and with emerging in-vessel core melt retention strategies for advanced light water reactor (ALWR) designs, recent interest in FCI has broadened to include an evaluation of potential threats to the integrity of reactor vessel lower head and ex-vessel structural support, as well as the role of FCI in debris quenching and coolability. The current understanding of FCI with regard to these issues is discussed, and future research needs to address the issues from a risk perspective are identified. (author)

  11. Archean to Recent aeolian sand systems and their preserved successions: current understanding and future prospects

    OpenAIRE

    Rodríguez-López, JP; Clemmensen, L; Lancaster, N.; Mountney, NP; Veiga, G

    2014-01-01

    The sedimentary record of aeolian sand systems extends from the Archean to the Quaternary, yet current understanding of aeolian sedimentary processes and product remains limited. Most preserved aeolian successions represent inland sand-sea or dunefield (erg) deposits, whereas coastal systems are primarily known from the Cenozoic. The complexity of aeolian sedimentary processes and facies variability are under-represented and excessively simplified in current facies models, which are not suffi...

  12. Current status of international training center for nuclear security and security issues in Korea

    International Nuclear Information System (INIS)

    During the 2010 Nuclear Security Summit (NSS) President Lee declared that Korea will establish an international training center (ITC) for nuclear security near the Korea Institute of Nuclear Nonproliferation and Control (KINAC). It will be open to the world in 2014. The government's long term goal is to make the center a hub for education and training in the nuclear field in Asia. The ITC will accomplish this by establishing facilities for practical and realistic exercises through the use of a test bed and various other experiments. The center will also provide comprehensive educational programs for nuclear newcomers. Its main programs include: a well designed educational program, customized training courses, and on-the-job training. This paper will discuss the current status of the ITC and describe practical plans for solving current security issues in Korea. (authors)

  13. A Person-Centered Approach to Understanding Negative Reinforcement Drinking Among First Year College Students

    Science.gov (United States)

    Holt, Laura J.; Armeli, Stephen; Tennen, Howard; Austad, Carol S.; Raskin, Sarah A.; Fallahi, Carolyn R.; Wood, Rebecca; Rosen, Rivkah I.; Ginley, Meredith K.; Pearlson, Godfrey D.

    2016-01-01

    The current study used a person-centered approach (i.e. latent class analysis) to identify distinct types of college student drinkers based on the predictions of motivational, social learning, and stress and coping theories of maladaptive drinking. A large sample (N=844; 53% female) of first-year undergraduates from two institutions, public and private, who reported consuming one or more drinks in the last three months completed measures of depression, anxiety, positive alcohol-outcome expectancies, negative life events, social support, drinking motives, drinking level and drinking-related problems. Latent class analysis revealed a small subgroup of individuals (n=81, 9%) who conformed to the anticipated high risk profile; specifically, this group demonstrated high levels of negative affect, coping motives, alcohol consumption and drinking-related problems. However, additional groups emerged that showed patterns inconsistent with the proposed vulnerability profile (e.g., high negative affect, positive expectancies, and life stress, but relatively low drinking levels). Findings from our person-centered approach showing the presence of groups both consistent and inconsistent with the predictions of motivational, social learning, and stress and coping theories highlight the need to identify and target certain college students for prevention and intervention of negative affect-related drinking. PMID:24064193

  14. Volatility of Common Protective Oxides in High-Temperature Water Vapor: Current Understanding and Unanswered Questions

    Science.gov (United States)

    Opila, Elizabeth J.

    2004-01-01

    Many structural materials rely on the formation of chromia, silica or alumina as a protective layer when exposed in high temperature oxidizing environments. The presence of these oxide layers provides a protective diffusion barrier which slows down further oxidation. In atmospheres containing water vapor, however, reactions to form volatile hydroxide species occur which remove the surface oxide, thus, lowering the protective capability of the oxide scale. This paper summarizes the current understanding of volatility of chromia, silica and alumina in water vapor containing combustion environments. In addition unanswered questions in each system are discussed. Th current paper represents an update on the considerable information learned in the past five years for these systems.

  15. The Current State of Poison Control Centers in Pakistan and the Need for Capacity Building

    Directory of Open Access Journals (Sweden)

    Nadeem Khan

    2014-03-01

    Full Text Available Background: Chemical exposure is a major health problem globally. Poison control centers (PCCs play a leading role both in developed and developing countries in the prevention and control of poisonous chemical exposures. In this study, we aimed to assess the current state of PCCs in Pakistan and highlight capacity building needs in these centers. Methods: A cross-sectional survey of the two registered PCCs was done during August – December 2011. Necessary services of the PCCs were evaluated and the data were recorded on a predesigned checklist. Results: Both PCCs are affiliated to a tertiary care hospital. Clinical services to poisoned patients were available 24 hours a day / 7 days a week. Information on common local products was available to poison center staff. Both centers were involved in undergraduate and post graduate teaching. Telephone poison information service was not available in either of centers. There was a limited capacity for qualitative and analytical toxicology. Common antidotes were available. There were limited surveillance activities to capture toxic risks existing in the community and also a deficiency was observed in chemical disaster planning. Conclusion: PCCs in Pakistan need capacity building for specialized training in toxicology, toxicovigilance, chemical disaster planning, analytical laboratory tests and telephone service for consultation in poisoning cases.   How to cite this article: Khan NU, Mir MU, Khan UR, Khan AR, Ara J, Raja K, et al. The Current State of Poison Control Centers in Pakistan and the Need for Capacity Building. Asia Pac J Med Toxicol 2014;3:31-5.

  16. Three Hours a Day: Understanding Current Teen Practices of Smartphone Application Use

    OpenAIRE

    Bentley, Frank; Church, Karen; Harrison, Beverly; Lyons, Kent; Rafalow, Matthew

    2015-01-01

    Teens are using mobile devices for an increasing number of activities. Smartphones and a variety of mobile apps for communication, entertainment, and productivity have become an integral part of their lives. This mobile phone use has evolved rapidly as technology has changed and thus studies from even 2 or 3 years ago may not reflect new patterns and practices as smartphones have become more sophisticated. In order to understand current teen's practices around smartphone use, we conducted a t...

  17. Current understanding of learning psychomotor skills and the impact on teaching laparoscopic surgical skills

    OpenAIRE

    White, Colette; Rodger, Matthew; Tang, Thomas

    2016-01-01

    Key content- Trainees face many challenges in learning the skill set required to perform laparoscopic surgery.- The time spent in the operating room has been detrimentally impacted upon since the implementation of the European Working Time Directive. In order to address the deficit, surgical educators have looked to the benefits enjoyed in the aviation and sports industries in using simulation training.Learning objectives- To summarise the current understanding of the neuropsychological basis...

  18. Current Understanding of the Binding Sites, Capacity, Affinity, and Biological Significance of Metals in Melanin

    OpenAIRE

    Hong, Lian; Simon, John D.

    2007-01-01

    Metal chelation is often invoked as one of the main biological functions of melanin. In order to understand the interaction between metals and melanin, extensive studies have been carried out to determine the nature of the metal binding sites, binding capacity and affinity. These data are central to efforts aimed at elucidating the role metal binding plays in determining the physical, structural, biological, and photochemical properties of melanin. This article examines the current state of u...

  19. Manifesto for the current understanding and management of traumatic brain injury-induced hypopituitarism.

    LENUS (Irish Health Repository)

    Tanriverdi, F

    2011-01-01

    Traumatic brain injury (TBI)-induced hypopituitarism remains a relevant medical problem, because it may affect a significant proportion of the population. In the last decade important studies have been published investigating pituitary dysfunction after TBI. Recently, a group of experts gathered and revisited the topic of TBI-induced hypopituitarism. During the 2-day meeting, the main issues of this topic were presented and discussed, and current understanding and management of TBI-induced hypopituitarism are summarized here.

  20. A historical study to understand students’ current difficulties about RMS values

    Science.gov (United States)

    Khantine-Langlois, Françoise; Munier, Valérie

    2016-07-01

    Several studies show that students experience more and more difficulties managing the measurements of electrical values in alternating current and that they have trouble making links between theory and practice. They find it difficult to give meaning to root mean square (RMS; or effective) values, which are not understood as average values and are confused with instantaneous values. This shows that students do not clearly differentiate variable and direct currents. In this paper we try, with a historical study and a study of teaching the concept of RMS values, to understand students’ difficulties with this concept. In the first part we present an epistemological analysis of the concept of RMS values, showing that it is multifaceted and can be approached from different points of view. In the second part we analyse the evolution of French secondary school curricula and textbooks from the explicit introduction of variable currents to today, questioning the links between the evolution of the curricula and the evolution of the place of science and technology in our societies. We point out that the evolution of the curricula is linked to the social context and to the connections between science, technology and society, and also to the relationship with mathematics curricula. We show that alternating current is introduced earlier in the curriculum but has gradually lost all phenomenological description. This study allows us to better understand students’ difficulties and to discuss some implications for teaching.

  1. History of the current understanding and management of tethered spinal cord.

    Science.gov (United States)

    Safavi-Abbasi, Sam; Mapstone, Timothy B; Archer, Jacob B; Wilson, Christopher; Theodore, Nicholas; Spetzler, Robert F; Preul, Mark C

    2016-07-01

    An understanding of the underlying pathophysiology of tethered cord syndrome (TCS) and modern management strategies have only developed within the past few decades. Current understanding of this entity first began with the understanding and management of spina bifida; this later led to the gradual recognition of spina bifida occulta and the symptoms associated with tethering of the filum terminale. In the 17th century, Dutch anatomists provided the first descriptions and initiated surgical management efforts for spina bifida. In the 19th century, the term "spina bifida occulta" was coined and various presentations of spinal dysraphism were appreciated. The association of urinary, cutaneous, and skeletal abnormalities with spinal dysraphism was recognized in the 20th century. Early in the 20th century, some physicians began to suspect that traction on the conus medullaris caused myelodysplasia-related symptoms and that prophylactic surgical management could prevent the occurrence of clinical manifestations. It was not, however, until later in the 20th century that the term "tethered spinal cord" and the modern management of TCS were introduced. This gradual advancement in understanding at a time before the development of modern imaging modalities illustrates how, over the centuries, anatomists, pathologists, neurologists, and surgeons used clinical examination, a high level of suspicion, and interest in the subtle and overt clinical appearances of spinal dysraphism and TCS to advance understanding of pathophysiology, clinical appearance, and treatment of this entity. With the availability of modern imaging, spinal dysraphism can now be diagnosed and treated as early as the intrauterine stage. PMID:26967990

  2. Dynamics of the Earth's Inner Magnetosphere and Its Connection to the Ionosphere: Current Understanding and Challenges

    Science.gov (United States)

    Zheng, Yihua

    2011-01-01

    The Earth's inner magnetosphere, a vast volume in space spanning from 1.5 Re (Earth radii) to 10 Re, is a host to a variety of plasma populations (with energy from 1 eV to few MeV) and physical processes where most of which involve plasma and field coupling. As a gigantic particle accelerator, the inner magnetosphere includes three overlapping regions: the plasmasphere, the ring current, and the Van Allen radiation belt. The complex structures and dynamics of these regions are externally driven by solar activities and internally modulated by intricate interactions and coupling. As a major constituent of Space Weather, the inner magnetosphere is both scientifically intriguing and practically important to our society. In this presentation, I will discuss our recent results from the Comprehensive Ring Current Model, in the context of our current understanding of the inner magnetosphere in general and challenges ahead in making further progresses.

  3. Room Temperature Magnetic Determination of the Current Center Line for the ITER TF Coils

    CERN Document Server

    Lerch, Philippe; Buzio, Marco; Negrazus, Marco; Baynham, Elwyn; Sanfilippo, Stephane; Foussat, Arnaud

    2014-01-01

    The ITER tokamak includes 18 superconducting D-shaped toroidal field (IT) coils. Unavoidable shape deformations as well as assembly errors will lead to field errors, which can be modeled with the knowledge of the current center line (CCL). Accurate survey during the entire manufacturing and assembly process, including transfer of survey points, is complex. In order to increase the level of confidence, a room temperature magnetic measurement of the CCL on assembled and closed winding packs is foreseen, prior to insertion into their cold case. In this contribution, we discuss the principle of the CCL determination and present a low frequency ac measurement system under development at PSI, within an ITER framework contract. The largest current allowed to flow in the TF coil at room temperature and the precision requirements for the determination of the CCL loci of the coil are hard boundaries. Eddy currents in the radial plates, the winding pack enclosures, and possibly from iron in the reinforced concrete floor...

  4. Pediatric Rotavirus Gastroenteritis: A 2 year Analysis to Understand Current Prevalence in Mumbai

    Directory of Open Access Journals (Sweden)

    Vidya Nerurkar

    2011-04-01

    Full Text Available Many studies have established the high prevalence of paediatric Rotavirus gastroenteritis in India. The importance of rapid diagnosis of rotavirus infection has also been stressed upon, to initiate prompt rehydration therapy and prevent unnecessary use of antibiotics .We undertook a retrospective analysis of 327 paediatric stool specimens to understand the current prevalence and seasonal distribution of cases in Mumbai and its surrounding areas. Overall Rotavirus positivity rate was 37.9 %, with peak positivity in winter seasons. Infections were more common upto 2 years of age. Incidence of bacterial and parasitic coinfections was low.

  5. Understanding and Predicting Social Media Use Among Community Health Center Patients: A Cross-Sectional Survey

    OpenAIRE

    Hanson, Carl L; West, Josh; Thackeray, Rosemary; Barnes, Michael D; Downey, Jordan

    2014-01-01

    Background The use of social media by health care organizations is growing and provides Web-based tools to connect patients, caregivers, and providers. Objective The aim was to determine the use and factors predicting the use of social media for health care–related purposes among medically underserved primary care patients. Methods A cross-sectional survey was administered to 444 patients of a federally qualified community health center. Results Community health center patients preferred that...

  6. Intergenerational Learning at a Nature Center: Families Using Prior Experiences and Participation Frameworks to Understand Raptors

    Science.gov (United States)

    Zimmerman, Heather Toomey; McClain, Lucy Richardson

    2014-01-01

    Using a sociocultural framework to approach intergenerational learning, this inquiry examines learning processes used by families during visits to one nature center. Data were collected from videotaped observations of families participating in an environmental education program and a follow-up task to draw the habitat of raptors. Based on a…

  7. Understanding and Engagement in Places of Science Experience: Science Museums, Science Centers, Zoos, and Aquariums

    Science.gov (United States)

    Schwan, Stephan; Grajal, Alejandro; Lewalter, Doris

    2014-01-01

    Science museums, science centers, zoos, and aquariums (MCZAs) constitute major settings of science learning with unique characteristics of informal science education. Emphasis will be given to the analysis of four specific characteristics of MCZAs that seem relevant for educational research and practice, namely, conditions of mixed motives and…

  8. Understanding and Reducing Obstacles in a Collaboration between a Minority Institution and a Cancer Center

    OpenAIRE

    Thompson, Beti; O’Connell, Mary; Löest, Helena; Anderson, Jennifer; Westcott, Rick

    2013-01-01

    Reducing the cancer incidence and mortality rates of underserved populations will require multidisciplinary efforts involving teams of diverse investigators. We describe a collaborative program between a National Cancer Institute-designated cancer center and a minority-serving institution. The organizations worked together to discover institutional and cultural barriers and facilitators to productive collaboration.

  9. A Review of the Current Literature on Executive Compensation: New Insights and Understandings

    Directory of Open Access Journals (Sweden)

    Phillip C. James

    2014-04-01

    Full Text Available There have been a number of research projects which examined the issue of executive compensation with the objective of identifying the factors that influence executive compensation. However, despite those attempts there is yet to be a comprehensive paper that brings all the possible factors together in order to provide a better understanding of the factors driving executive compensation. The objective of this paper is to present a thorough discussion on the main drivers of executive compensation. To achieve this objective, a review of the current literature of the major factors driving executive compensation as published in leading research journals was carried out. Among the drivers identified are: firm size and performance, corporate governance issues and agency problems, structure of the board of directors, executive power and tenure, market factors, insider trading restrictions, and company characteristics.

  10. Emergency nurses' current practices and understanding of family presence during CPR.

    LENUS (Irish Health Repository)

    Madden, Eilis

    2012-02-03

    PURPOSE: To examine emergency nurses\\' current practices and understanding of family presence during CPR in the emergency department, Cork University Hospital, Republic of Ireland. METHOD: A quantitative descriptive design was used in the study. A questionnaire developed by ENA was distributed to emergency nurses working in a level I trauma emergency department at Cork University Hospital. The total sample number was 90, including all emergency nurses with at least 6 months\\' emergency nursing experience. RESULTS: Emergency nurses often took families to the bedside during resuscitation efforts (58.9%) or would do so if the opportunity arose (17.8%). A high percentage (74.4%) of respondents would prefer a written policy allowing the option of family presence during CPR. The most significant barrier to family witnessed resuscitation (FWR) was conflicts occurring within the emergency team. The most significant facilitator to FWR was a greater understanding of health care professionals on the benefits of FWR to patients and families, indicating the need for educational development. CONCLUSION: The findings of the study and previously published studies indicate the need for development of written polices and guidelines on the practice to meet the needs of patients, families, and staff by providing consistent, safe, and caring practices for all involved in the resuscitation process. Recommendations of the study include the development of a written policy and an educational programme on the safe implementation and practices of FWR.

  11. Crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes

    KAUST Repository

    Wilson, S. K.

    2010-02-26

    Expert opinion was canvassed to identify crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes. Scientists that had published three or more papers on the effects of climate and environmental factors on reef fishes were invited to submit five questions that, if addressed, would improve our understanding of climate change effects on coral reef fishes. Thirty-three scientists provided 155 questions, and 32 scientists scored these questions in terms of: (i) identifying a knowledge gap, (ii) achievability, (iii) applicability to a broad spectrum of species and reef habitats, and (iv) priority. Forty-two per cent of the questions related to habitat associations and community dynamics of fish, reflecting the established effects and immediate concern relating to climate-induced coral loss and habitat degradation. However, there were also questions on fish demographics, physiology, behaviour and management, all of which could be potentially affected by climate change. Irrespective of their individual expertise and background, scientists scored questions from different topics similarly, suggesting limited bias and recognition of a need for greater interdisciplinary and collaborative research. Presented here are the 53 highest-scoring unique questions. These questions should act as a guide for future research, providing a basis for better assessment and management of climate change impacts on coral reefs and associated fish communities.

  12. Transcription Factors and Plants Response to Drought Stress: Current Understanding and Future Directions

    Science.gov (United States)

    Joshi, Rohit; Wani, Shabir H.; Singh, Balwant; Bohra, Abhishek; Dar, Zahoor A.; Lone, Ajaz A.; Pareek, Ashwani; Singla-Pareek, Sneh L.

    2016-01-01

    Increasing vulnerability of plants to a variety of stresses such as drought, salt and extreme temperatures poses a global threat to sustained growth and productivity of major crops. Of these stresses, drought represents a considerable threat to plant growth and development. In view of this, developing staple food cultivars with improved drought tolerance emerges as the most sustainable solution toward improving crop productivity in a scenario of climate change. In parallel, unraveling the genetic architecture and the targeted identification of molecular networks using modern “OMICS” analyses, that can underpin drought tolerance mechanisms, is urgently required. Importantly, integrated studies intending to elucidate complex mechanisms can bridge the gap existing in our current knowledge about drought stress tolerance in plants. It is now well established that drought tolerance is regulated by several genes, including transcription factors (TFs) that enable plants to withstand unfavorable conditions, and these remain potential genomic candidates for their wide application in crop breeding. These TFs represent the key molecular switches orchestrating the regulation of plant developmental processes in response to a variety of stresses. The current review aims to offer a deeper understanding of TFs engaged in regulating plant’s response under drought stress and to devise potential strategies to improve plant tolerance against drought. PMID:27471513

  13. Defining and Generating Axial Lines from Street Center Lines for better Understanding of Urban Morphologies

    CERN Document Server

    Liu, Xintao

    2010-01-01

    Axial lines are defined as the longest visibility lines for representing individual linear spaces in urban environments. The least number of axial lines that cover the free space of an urban environment constitute what is often called an axial map. This is a fundamental tool in space syntax, a theory developed by Bill Hillier and his colleagues for characterizing the underlying urban morphologies. For a long time, generating axial lines with help of some graphic software has been a tedious manual process that is criticized for being time consuming, subjective, or even arbitrary. In this paper, we redefine axial lines as the least number of individual straight line segments mutually intersected along natural streets that are generated from street center lines using the Gestalt principle of good continuity. Based on this new definition, we develop an automatic solution to generating the newly defined axial lines from street center lines. We apply this solution to six typical street networks (three from North Am...

  14. Self-assembling photosynthetic reaction centers on electrodes for current generation.

    Science.gov (United States)

    Nakamura, C; Hasegawa, M; Yasuda, Y; Miyake, J

    2000-01-01

    Photosynthetic reaction centers (RCs) made from photosynthetic organisms can be used in solar batteries because their molecules cause light-induced charge separation. We present a simple immobilization system of the intact RCs from Rhodobacter sphaeroides on an electrode that uses nickel ligand binding by the hexameric histidine tag on H subunit (HHisRC). The binding constant of HHisRC to the nickel-nitrilotriacetic acid (Ni-NTA) chip measured with a surface plasmon resonance instrument was 1.6 x 10(8) M-1. HHisRCs were immobilized on an indium tin oxide electrode overlaid with an Ni-NTA gold substrate. The photoinduced displacement current of this electrode was measured to estimate the orientation of HHisRC on the electrode, and the detachability of HHisRC from the electrode was determined by using an imidazole solution wash. The direction of the flash-light-induced displacement current suggested that the H subunit side of the immobilized HHisRC faced the surface of the electrode. The photoinduced current disappeared after the electrode was washed in the imidazole solution. This simple immobilization and detachment of HHisRC to the electrode might be useful for making a reproducible photocurrent device. PMID:10849806

  15. Current nanoscience and nanoengineering at the Center for Nanoscale Science and Engineering

    Science.gov (United States)

    Hermann, A. M.; Singh, R. S.; Singh, V. P.

    2006-07-01

    The Center for Nanoscale Science and Engineering (CeNSE) at the University of Kentucky is a multidisciplinary group of faculty, students, and staff, with a shared vision and cutting-edge research facilities to study and develop materials and devices at the nanoscale. Current research projects at CeNSE span a number of diverse nanoscience thrusts in bio- engineering and medicine (nanosensors and nanoelectrodes, nanoparticle-based drug delivery), electronics (nanolithography, molecular electronics, nanotube FETs), nanotemplates for electronics and gas sensors (functionalization of carbon nanotubes, aligned carbon nanotube structures for gate-keeping, e-beam lithography with nanoscale precision), and nano--optoelectronics (nanoscale photonics for laser communications, quantum confinement in photovoltaic devices, and nanostructured displays). This paper provides glimpses of this research and future directions.

  16. Current nanoscience and nanoengineering at the Center for Nanoscale Science and Engineering

    Indian Academy of Sciences (India)

    A M Hermann; R S Singh; V P Singh

    2006-07-01

    The Center for Nanoscale Science and Engineering (CeNSE) at the University of Kentucky is a multidisciplinary group of faculty, students, and staff, with a shared vision and cutting-edge research facilities to study and develop materials and devices at the nanoscale. Current research projects at CeNSE span a number of diverse nanoscience thrusts in bio-engineering and medicine (nanosensors and nanoelectrodes, nanoparticle-based drug delivery), electronics (nanolithography, molecular electronics, nanotube FETs), nanotem-plates for electronics and gas sensors (functionalization of carbon nanotubes, aligned carbon nanotube structures for gate-keeping, e-beam lithography with nanoscale precision), and nano–optoelectronics (nanoscale photonics for laser communications, quantum confinement in photovoltaic devices, and nanostructured displays). This paper provides glimpses of this research and future directions.

  17. Understanding the cancer cell phenotype beyond the limitations of current omics analyses.

    Science.gov (United States)

    Moreno-Sánchez, Rafael; Saavedra, Emma; Gallardo-Pérez, Juan Carlos; Rumjanek, Franklin D; Rodríguez-Enríquez, Sara

    2016-01-01

    Efforts to understand the mechanistic principles driving cancer metabolism and proliferation have been lately governed by genomic, transcriptomic and proteomic studies. This paper analyzes the caveats of these approaches. As molecular biology's central dogma proposes a unidirectional flux of information from genes to mRNA to proteins, it has frequently been assumed that monitoring the changes in the gene sequences and in mRNA and protein contents is sufficient to explain complex cellular processes. Such a stance commonly disregards that post-translational modifications can alter the protein function/activity and also that regulatory mechanisms enter into action, to coordinate the protein activities of pathways/cellular processes, in order to keep the cellular homeostasis. Hence, the actual protein activities (as enzymes/transporters/receptors) and their regulatory mechanisms ultimately dictate the final outcomes of a pathway/cellular process. In this regard, it is here documented that the mRNA levels of many metabolic enzymes and transcriptional factors have no correlation with the respective protein contents and activities. The validity of current clinical mRNA-based tests and proposed metabolite biomarkers for cancer detection/prognosis is also discussed. Therefore, it is proposed that, to achieve a thorough understanding of the modifications undergone by proliferating cancer cells, it is mandatory to experimentally analyze the cellular processes at the functional level. This could be achieved (a) locally, by examining the actual protein activities in the cell and their kinetic properties (or at least kinetically characterize the most controlling steps of the pathway/cellular process); (b) systemically, by analyzing the main fluxes of the pathway/cellular process, and how they are modulated by metabolites, all which should contribute to comprehending the regulatory mechanisms that have been altered in cancer cells. By adopting a more holistic approach it may

  18. Big Data and the Atmospheric Science Data Center: Improving Access and Understanding of Data Products

    Science.gov (United States)

    Mathews, T. J.; Little, M. M.; Huffer, E.

    2013-12-01

    Working from an Enterprise Architecture, the ASDC has implemented a suite of new tools to provide improved access and understanding of data products related to the Earth's radiation budget, clouds, aerosols and tropospheric chemistry. This poster describes the overall architecture and the capabilities that have been implemented within the past twelve months. Further insight is offered into the issues and constraints of those tools, as well as lessons learned in their implementation.

  19. Current ecological understanding of fungal-like pathogens of fish: what lies beneath?

    Directory of Open Access Journals (Sweden)

    Rodolphe Elie Gozlan

    2014-02-01

    Full Text Available Despite increasingly sophisticated microbiological techniques, and long after the first discovery of microbes, basic knowledge is still lacking to fully appreciate the ecological importance of microbial parasites in fish. This is likely due to the nature of their habitats as many species of fish suffer from living beneath turbid water away from easy recording. However, fishes represent key ecosystem services for millions of people around the world and the absence of a functional ecological understanding of viruses, prokaryotes, and small eukaryotes in the maintenance of fish populations and of their diversity represents an inherent barrier to aquatic conservation and food security. Among recent emerging infectious diseases responsible for severe population declines in plant and animal taxa, fungal and fungal-like microbes have emerged as significant contributors. Here, we review the current knowledge gaps of fungal and fungal-like parasites and pathogens in fish and put them into an ecological perspective with direct implications for the monitoring of fungal fish pathogens in the wild, their phylogeography as well as their associated ecological impact on fish populations. With increasing fish movement around the world for farming, releases into the wild for sport fishing and human-driven habitat changes, it is expected, along with improved environmental monitoring of fungal and fungal-like infections, that the full extent of the impact of these pathogens on wild fish populations will soon emerge as a major threat to freshwater biodiversity.

  20. Current understanding of the bi-directional relationship of major depression with inflammation

    Directory of Open Access Journals (Sweden)

    Messay Berhane

    2012-02-01

    Full Text Available Abstract Consistent evidence links major depression and its affective components to negative health outcomes. Although the pathways of these effects are likely complex and multifactorial, recent evidence suggests that innate inflammatory processes may play a role. An overview of current literature suggests that pathways between negative moods and inflammation are bi-directional. Indeed, negative moods activate peripheral physiologic mechanisms that result in an up regulation of systemic levels of inflammation. Conversely, peripheral inflammatory mediators signal the brain to affect behavioral, affective and cognitive changes that are consistent with symptoms of major depressive disorder. It is likely that these pathways are part of a complex feedback loop that involves the nervous, endocrine, and immune systems and plays a role in the modulation of peripheral inflammatory responses to central and peripheral stimuli, in central responses to peripheral immune activation and in the maintenance of homeostatic balance. Further research is warranted to fully understand the role of central processes in this feedback loop, which likely contributes to the pathophysiology of mental and physical health.

  1. Review: Animal model and the current understanding of molecule dynamics of adipogenesis.

    Science.gov (United States)

    Campos, C F; Duarte, M S; Guimarães, S E F; Verardo, L L; Wei, S; Du, M; Jiang, Z; Bergen, W G; Hausman, G J; Fernyhough-Culver, M; Albrecht, E; Dodson, M V

    2016-06-01

    Among several potential animal models that can be used for adipogenic studies, Wagyu cattle is the one that presents unique molecular mechanisms underlying the deposit of substantial amounts of intramuscular fat. As such, this review is focused on current knowledge of such mechanisms related to adipose tissue deposition using Wagyu cattle as model. So abundant is the lipid accumulation in the skeletal muscles of these animals that in many cases, the muscle cross-sectional area appears more white (adipose tissue) than red (muscle fibers). This enhanced marbling accumulation is morphologically similar to that seen in numerous skeletal muscle dysfunctions, disease states and myopathies; this might indicate cross-similar mechanisms between such dysfunctions and fat deposition in Wagyu breed. Animal models can be used not only for a better understanding of fat deposition in livestock, but also as models to an increased comprehension on molecular mechanisms behind human conditions. This revision underlies some of the complex molecular processes of fat deposition in animals. PMID:26776309

  2. Water Pollution Control Legislation in Israel: Understanding Implementation Processes from an Actor-Centered Approach

    Directory of Open Access Journals (Sweden)

    Sharon Hophmayer-Tokich

    2013-09-01

    Full Text Available In the State of Israel, advanced legislation for the management of scarce water resources, including legislation to prevent water pollution, were put in place in the early stages of the State’s formation. Despite that, on-going uncontrolled pollution has deteriorated the quality of water sources for decades, with the main source of pollution being untreated or partially treated domestic wastewater. This has been mainly the result of lack of enforcement of the existing laws. During the 1990s and onwards, a shift to forceful enforcement has been observed and wastewater treatment substantially improved. The paper analyzes the implementation processes of the pollution control legislations (the lack-of and the shift to forceful enforcement based on an actor-centered approach, using the contextual interaction theory.

  3. The effects of a visualization-centered curriculum on conceptual understanding and representational competence in high school biology

    Science.gov (United States)

    Wilder, Anna

    The purpose of this study was to investigate the effects of a visualization-centered curriculum, Hemoglobin: A Case of Double Identity, on conceptual understanding and representational competence in high school biology. Sixty-nine students enrolled in three sections of freshman biology taught by the same teacher participated in this study. Online Chemscape Chime computer-based molecular visualizations were incorporated into the 10-week curriculum to introduce students to fundamental structure and function relationships. Measures used in this study included a Hemoglobin Structure and Function Test, Mental Imagery Questionnaire, Exam Difficulty Survey, the Student Assessment of Learning Gains, the Group Assessment of Logical Thinking, the Attitude Toward Science in School Assessment, audiotapes of student interviews, students' artifacts, weekly unit activity surveys, informal researcher observations and a teacher's weekly questionnaire. The Hemoglobin Structure and Function Test, consisting of Parts A and B, was administered as a pre and posttest. Part A used exclusively verbal test items to measure conceptual understanding, while Part B used visual-verbal test items to measure conceptual understanding and representational competence. Results of the Hemoglobin Structure and Function pre and posttest revealed statistically significant gains in conceptual understanding and representational competence, suggesting the visualization-centered curriculum implemented in this study was effective in supporting positive learning outcomes. The large positive correlation between posttest results on Part A, comprised of all-verbal test items, and Part B, using visual-verbal test items, suggests this curriculum supported students' mutual development of conceptual understanding and representational competence. Evidence based on student interviews, Student Assessment of Learning Gains ratings and weekly activity surveys indicated positive attitudes toward the use of Chemscape Chime

  4. Development of a student-centered instrument to assess middle school students' conceptual understanding of sound

    Science.gov (United States)

    Eshach, Haim

    2014-06-01

    This article describes the development and field test of the Sound Concept Inventory Instrument (SCII), designed to measure middle school students' concepts of sound. The instrument was designed based on known students' difficulties in understanding sound and the history of science related to sound and focuses on two main aspects of sound: sound has material properties, and sound has process properties. The final SCII consists of 71 statements that respondents rate as either true or false and also indicate their confidence on a five-point scale. Administration to 355 middle school students resulted in a Cronbach alpha of 0.906, suggesting a high reliability. In addition, the average percentage of students' answers to statements that associate sound with material properties is significantly higher than the average percentage of statements associating sound with process properties (p <0.001). The SCII is a valid and reliable tool that can be used to determine students' conceptions of sound.

  5. Understanding the effect of vector dynamics in epidemic models using center manifold analysis

    Science.gov (United States)

    Rocha, Filipe; Aguiar, Maíra; Souza, Max; Stollenwerk, Nico

    2012-09-01

    In vector borne diseases the human hosts' epidemiology often acts on a much slower time scales than the one of the mosquitos which transmit the disease as a vector from human to human, due to their vastly different life cycles. We investigate in a model with susceptible (S), infected (I) and recovered (R) humans and susceptible (U) and infected (V) mosquitoes in how far the fast time scale of the mosquito epidemiology can be slaved by the slower human epidemiology, so that for the understanding of human disease data mainly the dynamics of the human time scale is essential and only slightly perturbed by the mosquito dynamics. This analysis of the SIRUV model is qualitatively in agreement with a previously investigated simpler SISUV model, hence a feature of vector-borne diseases in general.

  6. Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?

    Science.gov (United States)

    Holgate, Stephen T

    2011-09-01

    Current asthma therapy is based on the use of adrenergic bronchodilator and anti-inflammatory drugs the specificity, efficacy, duration of action, and safety of which have been derived through classical pharmacology and medicinal chemistry. That asthma is a T(H)2-type inflammatory disorder frequently associated with atopy and allergic comorbidities has led to a concentrated effort to find treatments that act selectively on this pathway. A systematic literature review was undertaken, as well as a review of the Web site Clinicaltrials.gov for ongoing trials. Targets have included T cells themselves and their associated cytokines, chemokines, and receptors mostly targeted with biological agents. With the exception of anti-human IgE, none of these have met the expectations predicted from animal models and human in vitro tests. For most of these new therapies, only a very small subpopulation appears to respond. A case is made for a different approach to drug discovery based on acquiring a greater understanding of asthma stratification, the relevant pathways involved, and the development of appropriate diagnostic tests enabling the targeting of selective treatments to those asthmatic phenotypes most likely to respond. The recognition that asthma is more than allergy mandates improved predictive animal models and an appreciation that many of the environmental insults that initiate, consolidate, and exacerbate asthma operate through an epithelium functioning in a disorderly fashion. An integrated model that places the epithelium at the forefront of asthma pathogenesis suggests that greater emphasis should be placed on therapeutics that increase the airways' resistance against the inhaled environment rather than focusing only on suppression of inflammation. PMID:21807404

  7. The North American Astronomical Photographic Plate Preservation & Digitization Center Current Status

    Science.gov (United States)

    Osborn, Wayne; Castelaz, M.; Cline, J. D.; Griffin, R. E.; Barker, T.

    2006-12-01

    The North American Astronomical Photographic Plate Center (NAPPC) was established at the Pisgah Astronomical Research Institute in 2004. The goal of the Center is to help preserve astronomical photographic data, first by serving as a long term repository for astronomical plate collections and eventually by digitizing the plate material of interest for research projects. In the three years of existence, the Center has received over 25,000 plates. The largest collections are CTIO 4-m plates, CTIO and Warner and Swasey direct and objective prism Schmidt plates, and U. Michigan spectra. Preliminary catalogues of the plates are being developed and placed on line (http://www.pari.edu/library/astronomical-plate-center). A small source of funding has been secured to support this work. Instructions will be available from the authors on the steps to follow for individuals or observatories wishing to archive plates at the Center.

  8. Current-direction dependence of the transport properties in single-crystalline face-centered-cubic cobalt films

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, X.; Liang, J. H.; Chen, B. L.; Li, J. X.; Ding, Z.; Wu, Y. Z., E-mail: wuyizheng@fudan.edu.cn [Department of Physics, State Key Laboratory of Surface Physics and Collaborative Innovation Center of Advanced Microstructures, Fudan University, Shanghai 200433 (China); Ma, D. H. [Department of Energy Engineering, Pennsylvania State University, University Park, Pennsylvania 16802 (United States)

    2015-07-28

    Face-centered-cubic cobalt films are epitaxially grown on insulating LaAlO{sub 3}(001) substrates by molecular beam epitaxy. Transport measurements are conducted in different current directions relative to the crystal axes. We find that the temperature dependent anisotropic magnetoresistance ratio strongly depends on the current direction. However, the anomalous Hall effect shows isotropic behavior independent of the current direction. Our results demonstrate the interplay between the current direction and the crystalline lattice in single-crystalline ferromagnetic films. A phenomenological analysis is presented to interpret the experimental data.

  9. Current understanding of the molecular basis of chloroquine-resistance in Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Jiang H

    2006-01-01

    Full Text Available Chloroquine (CQ is the most successful antimalarial drug ever discovered. Unfortunately, parasites resistant to the drug eventually emerged after its large scale use and are now widespread. Although great progress in our understanding of the mechanisms of CQ action and CQ resistance (CQR has been achieved over the past two decades, including the identification of the molecules responsible for CQR (e.g., Plasmodium falciparum chloroquine resistant transporter, PfCRT many questions remain unanswered. Here we highlight recent advances in our understanding of the genetics and molecular mechanisms of CQR, with particular emphasis on the role of genes such as pfcrt and pfmdr1 in the resistance to CQ and other drugs. New drug development and applications will undoubtedly benefit from a better understanding of CQR, eventually leading to more effective malaria control measures.

  10. Depairing critical current achieved in superconducting thin films with through-thickness arrays of artificial pinning centers

    OpenAIRE

    Dinner, Rafael B.; Robinson, Adam P.; Wimbush, Stuart C.; MacManus-Driscoll, Judith L; Blamire, Mark G.

    2010-01-01

    Large area arrays of through-thickness nanoscale pores have been milled into superconducting Nb thin films via a process utilizing anodized aluminum oxide thin film templates. These pores act as artificial flux pinning centers, increasing the superconducting critical current, Jc, of the Nb films. By optimizing the process conditions including anodization time, pore size and milling time, Jc values approaching and in some cases matching the Ginzburg-Landau depairing current of 30 MA/cm^2 at 5 ...

  11. Research on operation and maintenance support system adaptive to human recognition and understanding in human-centered plant

    International Nuclear Information System (INIS)

    As a human-centered plant, advanced nuclear power plant needs appropriate role sharing between human and mobile intelligent agents. Human-machine cooperation for plant operation and maintenance activities is also required with an advanced interface. Plant's maintenance is programmed using mobile robots working under the radiation environments instead of human beings. Operation and maintenance support system adaptive to human recognition and understanding should be developed to establish adequate human and machine interface so as to induce human capabilities to the full and enable human to take responsibility for plan's operation. Plant's operation and maintenance can be cooperative activities between human and intelligent automonous agents having surveillance and control functions. Infrastructure of multi-agent simulation system for the support system has been investigated and developed based on work plans derived from the scheduler. (T. Tanaka)

  12. Cancer Survivorship Research: A Review of the Literature and Summary of Current NCI-Designated Cancer Center Projects

    OpenAIRE

    Harrop, J. Phil; Dean, Julie A.; Paskett, Electra D.

    2011-01-01

    The number of cancer survivors and amount of cancer survivorship research has grown substantially during the past three decades. This paper provides a review of interventional and observational cancer survivorship research efforts as well as a summary of current cancer survivorship research projects being conducted by National Cancer Institute-designated cancer centers in an effort to identify areas that need further attention.

  13. Electrode-electrolyte interface in Li-ion batteries: current understanding and new insights.

    Science.gov (United States)

    Gauthier, Magali; Carney, Thomas J; Grimaud, Alexis; Giordano, Livia; Pour, Nir; Chang, Hao-Hsun; Fenning, David P; Lux, Simon F; Paschos, Odysseas; Bauer, Christoph; Maglia, Filippo; Lupart, Saskia; Lamp, Peter; Shao-Horn, Yang

    2015-11-19

    Understanding reactions at the electrode/electrolyte interface (EEI) is essential to developing strategies to enhance cycle life and safety of lithium batteries. Despite research in the past four decades, there is still limited understanding by what means different components are formed at the EEI and how they influence EEI layer properties. We review findings used to establish the well-known mosaic structure model for the EEI (often referred to as solid electrolyte interphase or SEI) on negative electrodes including lithium, graphite, tin, and silicon. Much less understanding exists for EEI layers for positive electrodes. High-capacity Li-rich layered oxides yLi2-xMnO3·(1-y)Li1-xMO2, which can generate highly reactive species toward the electrolyte via oxygen anion redox, highlight the critical need to understand reactions with the electrolyte and EEI layers for advanced positive electrodes. Recent advances in in situ characterization of well-defined electrode surfaces can provide mechanistic insights and strategies to tailor EEI layer composition and properties. PMID:26510477

  14. Trying to Get Ahead of the Curve: Raising and Understanding Current Themes in New Literacies Practices

    Science.gov (United States)

    Wilber, Dana

    2012-01-01

    This article addresses the following questions: What impact does using the theoretical framework of new literacies have on understanding language, literacy, and learning practices today as technologies are constantly being developed and used? What is the state of research in this area? What are some new directions the field might take in order to…

  15. Introduction to Indian Ocean biogeochemical processes and ecological variability: Current understanding and emerging perspectives

    Digital Repository Service at National Institute of Oceanography (India)

    Wiggert, J.D.; Hood, R.R.; Naqvi, S.W.A.; Brink, K.H.; Smith, S.L.

    of the equatorial cur- rents was also an open question, since zonal wind stress over the tropical Indian Ocean is unique in comparison with the Pacific and Atlantic oceans, so investigating this dynamic process was identified as a priority. A third prominent view... of the Indian Ocean’s com- plement of unique dynamical processes, biological measure- ments were also performed. These ultimately led to creation of several plankton and production atlases [e.g., Indian Ocean Biological Center, �968; Panikkar, �970; Krey...

  16. Magnetic resonance imaging of athletic pubalgia and the sports hernia: current understanding and practice.

    Science.gov (United States)

    Khan, Waseem; Zoga, Adam C; Meyers, William C

    2013-02-01

    Magnetic resonance imaging (MRI) has become the standard imaging modality for activity-related groin pain. Lesions, including rectus abdominis/adductor aponeurosis injury and osteitis pubis, can be accurately identified and delineated in patients with clinical conditions termed athletic pubalgia, core injury, and sports hernia. A dedicated noncontrast athletic pubalgia MRI protocol is easy to implement and should be available at musculoskeletal MR imaging centers. This article will review pubic anatomy, imaging considerations, specific lesions, and common MRI findings encountered in the setting of musculoskeletal groin pain. PMID:23168185

  17. Greek Primary School Teachers' Understanding of Current Environmental Issues: An Exploration of Their Environmental Knowledge and Images of Nature

    Science.gov (United States)

    Michail, Sirmo; Stamou, Anastasia G.; Stamou, George P.

    2007-01-01

    In this article, the Greek primary school teachers' understanding of three current environmental issues (acid rain, the ozone layer depletion, and the greenhouse effect) as well as the emerging images of nature were examined. The study revealed that teachers held several environmental knowledge gaps and misconceptions about the three phenomena.…

  18. Multiculturalism in current tourism: Can tourism and travelling help to improve tolerance and understanding?

    Directory of Open Access Journals (Sweden)

    Josefová Alena

    2016-01-01

    Full Text Available The article focuses on one of the most important issues of the beginning of the 21st century, which is unprecedented move of people. This political, sociological, geographical and psycho-linguistics phenomenon needs qualitatively new approaches in meeting races, cultures, religions, customs and habits. What are the possibilities of cohabitation of people in these new political, cultural and economic conditions? The way can be intercultural exchange characterised by mutual respect and the will to understand otherness and other values.

  19. Unprepared for boom or bust: understanding the current state fiscal crisis

    OpenAIRE

    Leslie McGranahan

    2002-01-01

    The headlines concerning state government finances have become increasingly alarming since mid-2001. This article discusses the roots of the current state fiscal crisis by looking at the decisions made by state government leaders during the long expansion. The author suggests increased use of rainy day funds as a way to avoid future crisis.

  20. Human factors implications of vehicle automation: Current understanding and future directions

    NARCIS (Netherlands)

    Merat, N.; de Waard, Dick

    2014-01-01

    Advances in vehicle-based technology are currently progressing at an ever- increasing rate and innovations in this area are no longer restricted to Original Equipment Manufacturers or the automotive industry, with service providers such as Google and a number of research institutes in Europe and Nor

  1. Oak Ridge Field Research Center Current Opportunities and Future Research Directions

    Energy Technology Data Exchange (ETDEWEB)

    Watson, David

    2005-04-20

    The objectives of this meeting are: (1) Understand fundamental biogeochemical processes influencing the use of bioremediation approaches for cleaning up, managing, or understanding fate and transport of metals and radionuclides at DOE's contaminated legacy waste sites; and (2) Promote coordination and efficient use of resources, and facilitate comparison and integration of data.

  2. Gold deposits in metamorphic belts: Overview of current understanding, outstanding problems, future research, and exploration significance

    Science.gov (United States)

    Groves, D.I.; Goldfarb, R.J.; Robert, F.; Hart, C.J.R.

    2003-01-01

    Metamorphic belts are complex regions where accretion or collision has added to, or thickened, continental crust. Gold-rich deposits can be formed at all stages of orogen evolution, so that evolving metamorphic belts contain diverse gold deposit types that may be juxtaposed or overprint each other. This partly explains the high level of controversy on the origin of some deposit types, particularly those formed or overprinted/remobilized during the major compressional orogeny that shaped the final geometry of the hosting metamorphic belts. These include gold-dominated orogenic and intrusion-related deposits, but also particularly controversial gold deposits with atypical metal associations. There are a number of outstanding problems for all types of gold deposits in metamorphc belts. These include the following: (1) definitive classifications, (2) unequivocal recognition of fluid and metal sources, (3) understanding of fluid migration and focusing at all scales, (4) resolution of the precise role of granitoid magmatism, (5) precise gold-depositional mechanisms, particularly those producing high gold grades, and (6) understanding of the release of CO2-rich fluids from subducting slabs and subcreted oceanic crust and granitoid magmas at different crustal levels. Research needs to be better coordinated and more integrated, such that detailed fluid-inclusion, trace-element, and isotopic studies of both gold deposits and potential source rocks, using cutting-edge technology, are embedded in a firm geological framework at terrane to deposit scales. Ultimately, four-dimensional models need to be developed, involving high-quality, three-dimensional geological data combined with integrated chemical and fluid-flow modeling, to understand the total history of the hydrothermal systems involved. Such research, particularly that which can predict superior targets visible in data sets available to exploration companies before discovery, has obvious spin-offs for global- to deposit

  3. Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin Contamination

    Directory of Open Access Journals (Sweden)

    Jiujiang Yu

    2012-10-01

    Full Text Available Traditional molecular techniques have been used in research in discovering the genes and enzymes that are involved in aflatoxin formation and genetic regulation. We cloned most, if not all, of the aflatoxin pathway genes. A consensus gene cluster for aflatoxin biosynthesis was discovered in 2005. The factors that affect aflatoxin formation have been studied. In this report, the author summarized the current status of research progress and future possibilities that may be used for solving aflatoxin contamination.

  4. Human factors implications of vehicle automation: Current understanding and future directions

    OpenAIRE

    Merat, N.; de Waard, Dick

    2014-01-01

    Advances in vehicle-based technology are currently progressing at an ever- increasing rate and innovations in this area are no longer restricted to Original Equipment Manufacturers or the automotive industry, with service providers such as Google and a number of research institutes in Europe and North America also offering possibilities for new approaches to mobility (see http://www.driverless-future.com/?page_id=155). The race to test the first fleet of such vehicles on public roads is curre...

  5. Current Understanding of Molecular Pathology and Treatment of Cardiomyopathy in Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    Tirsa L. E. van Westering

    2015-05-01

    Full Text Available Duchenne muscular dystrophy (DMD is a genetic muscle disorder caused by mutations in the Dmd gene resulting in the loss of the protein dystrophin. Patients do not only experience skeletal muscle degeneration, but also develop severe cardiomyopathy by their second decade, one of the main causes of death. The absence of dystrophin in the heart renders cardiomyocytes more sensitive to stretch-induced damage. Moreover, it pathologically alters intracellular calcium (Ca2+ concentration, neuronal nitric oxide synthase (nNOS localization and mitochondrial function and leads to inflammation and necrosis, all contributing to the development of cardiomyopathy. Current therapies only treat symptoms and therefore the need for targeting the genetic defect is immense. Several preclinical therapies are undergoing development, including utrophin up-regulation, stop codon read-through therapy, viral gene therapy, cell-based therapy and exon skipping. Some of these therapies are undergoing clinical trials, but these have predominantly focused on skeletal muscle correction. However, improving skeletal muscle function without addressing cardiac aspects of the disease may aggravate cardiomyopathy and therefore it is essential that preclinical and clinical focus include improving heart function. This review consolidates what is known regarding molecular pathology of the DMD heart, specifically focusing on intracellular Ca2+, nNOS and mitochondrial dysregulation. It briefly discusses the current treatment options and then elaborates on the preclinical therapeutic approaches currently under development to restore dystrophin thereby improving pathology, with a focus on the heart.

  6. Carbon dynamics and changing winter conditions: a review of current understanding and future research directions

    Science.gov (United States)

    Haei, M.; Laudon, H.

    2015-09-01

    Despite the important role of winters for northern ecosystems, it remains the least understood of all the seasons. Here, we summarize existing empirical studies on winter climate and carbon dynamics and highlight some important future research directions. The existing studies include field-scale snow-cover manipulation experiments representing extreme soil climate conditions, laboratory soil incubations studying the influential factors, and time-series of climate and carbon data showing long-term natural variations and existing trends. Most of the field and laboratory experiments indicate an increased soil organic carbon loss due to soil frost. Long-term data demonstrate temporal changes in winter CO2 efflux and its important contribution to the annual fluxes. A number of research priorities to improve our understanding of winter conditions include (i) ecosystem processes in the fall-winter and winter-spring shoulder seasons, (ii) extreme events, (iii) partitioning into organic- and inorganic carbon, (iv) carry-over effects of winter and growing season on each other, (v) long-term cumulative impacts, and (vi) improved winter process modelling. These areas of research would enable an improved understanding of the role of the snow covered period for carbon cycling, and provide a basis for more realistic models that include winter processes.

  7. Proceedings of RIKEN BNL Research Center Workshop: Understanding QGP through Spectral Functions and Euclidean Correlators (Volume 89)

    Energy Technology Data Exchange (ETDEWEB)

    Mocsy,A.; Petreczky, P.

    2008-06-27

    In the past two decades, one of the most important goals of the nuclear physics community has been the production and characterization of the new state of matter--Quark-Gluon Plasma (QGP). Understanding how properties of hadrons change in medium, particularly, the bound state of a very heavy quark and its antiquark, known as quarkonium, as well as determining the transport coefficients is crucial for identifying the properties of QGP and for the understanding of the experimental data from RHIC. On April 23rd, more than sixty physicists from twenty-seven institutions gathered for this three-day topical workshop held at BNL to discuss how to understand the properties of the new state of matter obtained in ultra-relativistic heavy ion collisions (particularly at RHIC-BNL) through spectral functions. In-medium properties of the different particle species and the transport properties of the medium are encoded in spectral functions. The former could yield important signatures of deconfinement and chiral symmetry restoration at high temperatures and densities, while the later are crucial for the understanding of the dynamics of ultra-relativistic heavy ion collisions. Participants at the workshop are experts in various areas of spectral function studies. The workshop encouraged direct exchange of scientific information among experts, as well as between the younger and the more established scientists. The workshops success is evident from the coherent picture that developed of the current understanding of transport properties and in-medium particle properties, illustrated in the current proceedings. The following pages show calculations of meson spectral functions in lattice QCD, as well as implications of these for quarkonia melting/survival in the quark gluon plasma; Lattice calculations of the transport coefficients (shear and bulk viscosities, electric conductivity); Calculation of spectral functions and transport coefficients in field theories using weak coupling

  8. Proceedings of RIKEN BNL Research Center Workshop: Understanding QGP through Spectral Functions and Euclidean Correlators (Volume 89)

    International Nuclear Information System (INIS)

    In the past two decades, one of the most important goals of the nuclear physics community has been the production and characterization of the new state of matter--Quark-Gluon Plasma (QGP). Understanding how properties of hadrons change in medium, particularly, the bound state of a very heavy quark and its antiquark, known as quarkonium, as well as determining the transport coefficients is crucial for identifying the properties of QGP and for the understanding of the experimental data from RHIC. On April 23rd, more than sixty physicists from twenty-seven institutions gathered for this three-day topical workshop held at BNL to discuss how to understand the properties of the new state of matter obtained in ultra-relativistic heavy ion collisions (particularly at RHIC-BNL) through spectral functions. In-medium properties of the different particle species and the transport properties of the medium are encoded in spectral functions. The former could yield important signatures of deconfinement and chiral symmetry restoration at high temperatures and densities, while the later are crucial for the understanding of the dynamics of ultra-relativistic heavy ion collisions. Participants at the workshop are experts in various areas of spectral function studies. The workshop encouraged direct exchange of scientific information among experts, as well as between the younger and the more established scientists. The workshops success is evident from the coherent picture that developed of the current understanding of transport properties and in-medium particle properties, illustrated in the current proceedings. The following pages show calculations of meson spectral functions in lattice QCD, as well as implications of these for quarkonia melting/survival in the quark gluon plasma; Lattice calculations of the transport coefficients (shear and bulk viscosities, electric conductivity); Calculation of spectral functions and transport coefficients in field theories using weak coupling

  9. Nitrogen-Vacancy Centers in Diamond for Current Imaging at the Redistributive Layer Level of Integrated Circuits

    CERN Document Server

    Nowodzinski, Antoine; Toraille, Loïc; Jacques, Vincent; Roch, Jean-François; Debuisschert, Thierry

    2015-01-01

    We present a novel technique based on an ensemble of Nitrogen-Vacancy (NV) centers in diamond to perform Magnetic Current Imaging (MCI) on an Integrated Circuit (IC). NV centers in diamond allow measuring the three components of the magnetic fields generated by a mA range current in an IC structure over a field of 50 x 200 {\\mu}m^2 with sub-micron resolution. Vector measurements allow using a more robust algorithm than those used for MCI using Giant Magneto Resistance (GMR) or Superconducting Quantum Interference Device (SQUID) sensors and it is opening new current reconstruction prospects. Calculated MCI from these measurements shows a very good agreement with theoretical current path. Acquisition time is around 10 sec, which is much faster than scanning measurements using SQUID or GMR. The experimental set-up relies on a standard optical microscope, and the measurements can be performed at room temperature and atmospheric pressure. These early experiments, not optimized for IC, show that NV centers in diamo...

  10. Steep Electron Density Gradients in the Midlatitude Nighttime Ionosphere: Current Understanding and Future Directions

    Science.gov (United States)

    Makela, J. J.; Kelley, M. C.; Mathews, J. D.; Kintner, P. M.; Aponte, N.; Ledvina, B. M.; Nicolls, M. J.; Seker, I.

    2004-12-01

    The midlatitude nighttime ionosphere is generally considered to be a fairly quiet system. Indeed, when compared to the highly active low- and high-latitudes, this seems to be a valid description. However, observations in the 1990s, notably those conducted as part of the multi-instrument Combined Ionospheric Campaigns (CICs) carried out periodically from 1997 to 1999, have shown that disturbances can indeed occur in this region. For example, a relatively common feature seen in allsky images taken at 630.0 nm are bands of depleted intensity aligned from the northwest to southeast that propagate to the southwest (in the northern hemisphere). The general characteristics of these bands are now fairly well documented, as is the basic understanding of their underlying physics. The effects of these medium-scale traveling ionospheric disturbances, or electrobouyancy waves, is to produce gradients in the electron density and F-layer height. During quiet magnetic periods, these gradients are fairly small, of the order of a few TEC units. However, these structures seem to be amplified by high geomagnetic activity at which times the gradients can be of the order of 10 to 20 TEC units over distances as small as several 10s of kilometers. Although much was learned about these structures during the CICs of the late 1990s, there are still several unexplained features that warrant further investigation, notably their genesis region, Kp dependence, and effects (if any) on trans-ionospheric radio signals. We suggest the need for a new set of campaigns in the Caribbean to address these questions, modeled on the CICs but extending their spatial coverage and including additional instrumentation not available during the initial campaigns. It is only through such a comprehensive, multi-technique investigation that we will make further headway on understanding these phenomena.

  11. Status of High Latitude Precipitation Estimates: The Role of GPM in Advancing our Current Understanding

    Science.gov (United States)

    Behrangi, A.; Richardson, M.; Christensen, M.; Huffman, G. J.; Adler, R. F.; Stephens, G. L.; Lambrigtsen, B.

    2015-12-01

    This presentation reviews the current status of precipitation estimation from observation and reanalysis at high latitudes and discusses new insights gained by GPM. An intercomparison of high-latitude precipitation characteristics from observation-based and reanalysis products is performed. Precipitation products from GPM and the cloud profiling radar on the CloudSat satellite provide an independent assessment to other products which have already been widely used, these being the observationally-based GPCP, GPCC and CMAP and the reanalyses ERA-Interim, MERRA and NCEP-DOE. Seasonal and annual total precipitation in both hemispheres poleward of 55° latitude is considered in all products, and GPM and CloudSat products are used to assess frequency of precipitation occurrence by phase, defined as rain, snow or mixed phase. Estimates of snowfall over Antarctica and Greenland are compared from various products. A number of disagreements on regional or seasonal scales are identified which will be reported and discussed. These estimates from observations and reanalyses provide useful insights for diagnostic assessment of precipitation products in high latitudes, quantifying the current uncertainties among observations and reanalyses, and establishing a benchmark for assessment of climate models.

  12. Liquid Water Cloud Measurements Using the Raman Lidar Technique: Current Understanding and Future Research Needs

    Science.gov (United States)

    Tetsu, Sakai; Whiteman, David N.; Russo, Felicita; Turner, David D.; Veselovskii, Igor; Melfi, S. Harvey; Nagai, Tomohiro; Mano, Yuzo

    2013-01-01

    This paper describes recent work in the Raman lidar liquid water cloud measurement technique. The range-resolved spectral measurements at the National Aeronautics and Space Administration Goddard Space Flight Center indicate that the Raman backscattering spectra measured in and below low clouds agree well with theoretical spectra for vapor and liquid water. The calibration coefficients of the liquid water measurement for the Raman lidar at the Atmospheric Radiation Measurement Program Southern Great Plains site of the U.S. Department of Energy were determined by comparison with the liquid water path (LWP) obtained with Atmospheric Emitted Radiance Interferometer (AERI) and the liquid water content (LWC) obtained with the millimeter wavelength cloud radar and water vapor radiometer (MMCR-WVR) together. These comparisons were used to estimate the Raman liquid water cross-sectional value. The results indicate a bias consistent with an effective liquid water Raman cross-sectional value that is 28%-46% lower than published, which may be explained by the fact that the difference in the detectors' sensitivity has not been accounted for. The LWP of a thin altostratus cloud showed good qualitative agreement between lidar retrievals and AERI. However, the overall ensemble of comparisons of LWP showed considerable scatter, possibly because of the different fields of view of the instruments, the 350-m distance between the instruments, and the horizontal inhomogeneity of the clouds. The LWC profiles for a thick stratus cloud showed agreement between lidar retrievals andMMCR-WVR between the cloud base and 150m above that where the optical depth was less than 3. Areas requiring further research in this technique are discussed.

  13. The Hyaluronic Acid Fillers: Current Understanding of the Tissue Device Interface.

    Science.gov (United States)

    Greene, Jacqueline J; Sidle, Douglas M

    2015-11-01

    The article is a detailed update regarding cosmetic injectable fillers, specifically focusing on hyaluronic acid fillers. Hyaluronic acid-injectable fillers are used extensively for soft tissue volumizing and contouring. Many different hyaluronic acid-injectable fillers are available on the market and differ in terms of hyaluronic acid concentration, particle size, cross-linking density, requisite needle size, duration, stiffness, hydration, presence of lidocaine, type of cross-linking technology, and cost. Hyaluronic acid is a natural component of many soft tissues, is identical across species minimizing immunogenicity has been linked to wound healing and skin regeneration, and is currently actively being studied for tissue engineering purposes. The biomechanical and biochemical effects of HA on the local microenvironment of the injected site are key to its success as a soft tissue filler. Knowledge of the tissue-device interface will help guide the facial practitioner and lead to optimal outcomes for patients. PMID:26505539

  14. Understanding and modeling turbulent fluxes and entrainment in a gravity current

    CERN Document Server

    Odier, P; Ecke, R E

    2015-01-01

    We present an experimental study of the mixing processes in a gravity current flowing on an inclined plane. The turbulent transport of momentum and density can be described in a very direct and compact form by a Prandtl mixing length model: the turbulent vertical fluxes of momentum and density are found to scale quadratically with the vertical mean gradients of velocity and density. The scaling coefficient, the square of the mixing length, is approximately constant over the mixing zone of the stratified shear layer. We show how, in different flow configurations, this length can be related to the shear length of the flow ($\\epsilon$/$\\partial$ z u^3)^1/2. We also study the fluctuations of the momentum and density turbulent fluxes, showing how they relate to mixing and to the entrainment/detrainment balance. We suggest a quantitative measure of local entrainment and detrainment derived from observed conditional correlations of density flux and density or vertical velocity fluctuations.

  15. Tier 2 center GoeGrid, current status and future plans

    International Nuclear Information System (INIS)

    GoeGrid is the world-wide LHC computing grid (WLCG) Tier 2 center in Goettingen and is a part of the ATLAS Distributed Computing (ADC) infrastructure. The center is actively involved in ATLAS Distributed production and analysis processes since 2008. It provides computational power of 305 computing nodes with more than 2700 cores, storage space from 25 servers with capacity of 1.1 PB in total and local network of 10 Gb/s. The stable performance of the GoeGrid that is reflected in the reliability and availability reports is achieved through the efficient administration and in time problem detection which is done using the meta-monitoring framework HappyFace. From the experience gained during the operation of the Tier 2 center, there is a collection of scripts for solution of simple problems. This fact served as a motivation to build the problem evaluation, detection and action taking system, which will be based on a Fuzzy Neural Network approach and will use the monitoring data from the HappyFace framework. This system should help the site administrator to automate all routine and time consuming work and also to get suggestions and hints for possible solutions of the problem; even more, solve simple problems based on accumulated knowledge automatically.

  16. Current understanding of dystrophin-related muscular dystrophy and therapeutic challenges ahead

    Institute of Scientific and Technical Information of China (English)

    ZHOU Guang-qian; XIE Hui-qi; ZHANG Su-zhen; YANG Zhi-ming

    2006-01-01

    Objective To review the recent research progress in dystrophin-related muscular dystrophy includes X-linked hereditary Duchenne and Becker muscular dystrophies (DMD and BMD).Data sources Information included in this article was identified by searches of PUBMED and other online resources using the key terms DMD, dystrophin, mutations, animal models, pathophysiology, gene expression, stem cells, gene therapy, cell therapy, and pharmacological.Study selection Mainly original milestone articles and timely reviews written by major pioneer investigators of the field were selected.Results The key issues related to the genetic basis and pathophysiological factors of the diseases were critically addressed. The availabilities and advantages of various animal models for the diseases were described. Major molecular and cellular therapeutic approaches were also discussed, many of which have indeed exhibited some success in pre-clinical studies but at the same time encountered a number of technical hurdles, including the efficient and systemic delivery of a functional gene and myogenic precursor/stem cells to repair genetic defects.Conclusions Further understanding of pathophysiological mechanisms at molecular levels and regenerative properites of myogenic precursor/stem cells will promote the development of multiple therapeutic strategies. The combined use of multiple strategies may represent the major challenge as well as the greatest hope for the therapy of these diseases in coming years.

  17. Current Understanding of Dysbiosis in Disease in Human and Animal Models.

    Science.gov (United States)

    DeGruttola, Arianna K; Low, Daren; Mizoguchi, Atsushi; Mizoguchi, Emiko

    2016-05-01

    Inflammatory bowel disease (IBD) is an intestinal inflammatory condition that affects more than 2 million people in the United States. Although the etiology and pathogenesis of IBD are still largely unknown, dysregulated host/enteric microbial interactions are requisite for the development of IBD. So far, many researchers have tried to identify a precise relationship between IBD and an imbalance of the intestinal microbiota, termed "dysbiosis." Despite extensive efforts, it is still largely unknown about the interplay among microbes, their hosts, and their environments, and whether dysbiosis is a causal factor or an effect of IBD. Recently, deep-sequencing analyses of the microbiota in patients with IBD patients have been instrumental in characterizing the strong association between dysbiosis and IBD development, although it is still unable to identify specific-associated species level changes in most cases. Based on many recent reports, dysbiosis of the commensal microbiota is implicated in the pathogenesis of several diseases, including IBD, obesity, and allergic disorders, in both human and animal models. In this review article, the authors have focused on explaining the multiple types of dysbiosis, as well as dysbiosis-related diseases and potential treatments to apply this knowledge to understand a possible cause and potentially find therapeutic strategies for IBD as well as the other dysbiosis-related diseases. PMID:27070911

  18. Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment

    Science.gov (United States)

    McHale, Cliona M.; Zhang, Luoping; Smith, Martyn T.

    2012-01-01

    Benzene causes acute myeloid leukemia and probably other hematological malignancies. As benzene also causes hematotoxicity even in workers exposed to levels below the US permissible occupational exposure limit of 1 part per million, further assessment of the health risks associated with its exposure, particularly at low levels, is needed. Here, we describe the probable mechanism by which benzene induces leukemia involving the targeting of critical genes and pathways through the induction of genetic, chromosomal or epigenetic abnormalities and genomic instability, in a hematopoietic stem cell (HSC); stromal cell dysregulation; apoptosis of HSCs and stromal cells and altered proliferation and differentiation of HSCs. These effects modulated by benzene-induced oxidative stress, aryl hydrocarbon receptor dysregulation and reduced immunosurveillance, lead to the generation of leukemic stem cells and subsequent clonal evolution to leukemia. A mode of action (MOA) approach to the risk assessment of benzene was recently proposed. This approach is limited, however, by the challenges of defining a simple stochastic MOA of benzene-induced leukemogenesis and of identifying relevant and quantifiable parameters associated with potential key events. An alternative risk assessment approach is the application of toxicogenomics and systems biology in human populations, animals and in vitro models of the HSC stem cell niche, exposed to a range of levels of benzene. These approaches will inform our understanding of the mechanisms of benzene toxicity and identify additional biomarkers of exposure, early effect and susceptibility useful for risk assessment. PMID:22166497

  19. Two-phase unsaturated flow at Yucca Mountain, Nevada: A report on current understanding

    Science.gov (United States)

    Pruess, Karsten

    Thick unsaturated zones in semi-arid regions have some unique attributes that are favorable for long-term isolation of hazardous wastes. The disposal concept at Yucca Mountain takes advantage of low ambient water fluxes. Evaluation of site suitability must be based on an understanding of two-phase (liquid-gas) fluid flow and heat transfer processes in a heterogeneous, fractured rock mass. A large body of relevant knowledge has been accumulated in various fields, including petroleum and geothermal reservoir engineering, chemical engineering, civil engineering, and soil science. Complications at Yucca Mountain arise from the partly episodic and localized nature of water seepage in fracture networks. This limits the applicability of spatial and temporal averaging, and poses great challenges for numerical modeling. Significant flow and heat transfer effects may occur in the gas phase. Observations of natural and man-made chemical tracers as well as controlled field experiments have provided much useful information on mass transport at Yucca Mountain, including the occurrence of fast preferential flow. It is now clear that fracture-matrix interactions are considerably weaker than would be expected from a concept of water flowing in fractures as areally extensive sheets. The Yucca Mountain system is expected to be quite robust in coping with larger seepage rates, as may occur under future more pluvial climatic conditions.

  20. Current status of quality evaluation of nursing care through director review and reflection from the Nursing Quality Control Centers

    OpenAIRE

    Duan, Xia; Shi, Yan

    2014-01-01

    Background: The quality evaluation of nursing care is a key link in medical quality management. It is important and worth studying for the nursing supervisors to know the disadvantages during the process of quality evaluation of nursing care and then to improve the whole nursing quality. This study was to provide director insight on the current status of quality evaluation of nursing care from Nursing Quality Control Centers (NQCCs). Material and Methods: This qualitative study used a sample ...

  1. Current situation of sexual and reproductive health of men deprived of liberty in the Institutional Care Center of San Jose

    OpenAIRE

    Dorita Rivas Fonseca; Adriana Ortiz Obando

    2013-01-01

    The objective of this research was to determine the current status of the issue of sexual and reproductive health ofthe prisoners Institutional Care Center (CAI) of San Jose. It is a descriptive study. Through a strategic samplingdetermined the participation of 102 men. The information was obtained by applying a self-administeredquestionnaire with closed and open questions. As a result relevant to your socio-demographic profile, it appearsthat deprived of their liberty is a very heterogeneous...

  2. Current Understanding and Future Prospects of Host Selection, Acceptance, Discrimination, and Regulation of Phorid Fly Parasitoids That Attack Ants

    OpenAIRE

    Mathis, Kaitlyn A.; Stacy M. Philpott

    2012-01-01

    Phorid fly parasitoids (Diptera: Phoridae) have evolved a diverse array of cues used to successfully parasitize their ant hosts. Successful parasitism often involves (a) host habitat location, (b) host location, (c) host acceptance, (d) host discrimination, and (e) host regulation. In this paper we discuss our current understanding of how phorid flies use each of these steps to successfully parasitize ant hosts. We examine the wide variety of strategies and cues used by a multiple species of ...

  3. Measurement of weak magnetic field of corrosion current of isolated corrosion center

    Directory of Open Access Journals (Sweden)

    I. V. Bardin

    2015-01-01

    Full Text Available A very small magnetic field of corrosion current, of the order of 10−4 Oe, generated by isolated zinc inclusion in a copper platelet placed in electrolyte has been measured for the first time with a highly sensitive giant magneto-impedance magnetometer. The total corrosion current of the inclusion is estimated comparing the measured magnetic field distribution with corresponding theoretical calculation. The estimated value of the total corrosion current turns out to be in reasonable agreement with that one obtained in the standard gravimetric measurement.

  4. A Short Review on the Current Understanding of Autism Spectrum Disorders.

    Science.gov (United States)

    Park, Hye Ran; Lee, Jae Meen; Moon, Hyo Eun; Lee, Dong Soo; Kim, Bung-Nyun; Kim, Jinhyun; Kim, Dong Gyu; Paek, Sun Ha

    2016-02-01

    Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the first 3 years of life. It is not a single disorder, and it is broadly considered to be a multi-factorial disorder resulting from genetic and non-genetic risk factors and their interaction. Genetic studies of ASD have identified mutations that interfere with typical neurodevelopment in utero through childhood. These complexes of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have provided many important insights into the pathological changes that occur in the brain of patients with ASD in vivo. Especially, the role of amygdala, a major component of the limbic system and the affective loop of the cortico-striatothalamo-cortical circuit, in cognition and ASD has been proved in numerous neuropathological and neuroimaging studies. Besides the amygdala, the nucleus accumbens is also considered as the key structure which is related with the social reward response in ASD. Although educational and behavioral treatments have been the mainstay of the management of ASD, pharmacological and interventional treatments have also shown some benefit in subjects with ASD. Also, there have been reports about few patients who experienced improvement after deep brain stimulation, one of the interventional treatments. The key architecture of ASD development which could be a target for treatment is still an uncharted territory. Further work is needed to broaden the horizons on the understanding of ASD. PMID:26924928

  5. Current understanding of contrast media reactions and implications for clinical management.

    Science.gov (United States)

    Meth, Marc J; Maibach, Howard I

    2006-01-01

    Iodinated contrast media (CM) are an integral part of modern diagnostic medicine. Although these agents are considered to be relatively safe, adverse effects in the form of allergy-like reactions occur in a significant number of exposed patients. These reactions may be divided into immediate and delayed responses. Immediate (within 1 hour of administration) anaphylactic reactions range from urticaria and angioedema to laryngeal oedema, hypotension and even death. Delayed reactions to CM occur from 1 hour to 1 week after administration and usually have mostly cutaneous manifestations. History of prior CM reactions and atopy predispose patients to CM reactions. Despite intense research into the pathogenesis of the immediate anaphylactoid responses, new evidence shows that true IgE type I hypersensitivity mediation occurs only in rare, severe cases. The aetiology appears to be multifactorial in most individuals. There is strong evidence to conclude that type IV hypersensitivity is responsible for the delayed reactions to CM. Although switching to non-ionic agents significantly reduces the incidence of immediate reactions to CM, there is little consensus regarding corticosteroid prophylaxis in high-risk individuals. Skin testing and provocative challenges also provide little security. Therefore, physicians must be better prepared to treat immediate anaphylactoid responses. Preventing delayed CM reactions is best performed with patch and delayed intradermal testing in those with a history of prior reactions, although false-negative results have been reported. Corticosteroids and antihistamines may be required for treatment. Until newer agents are developed that negate these issues, healthcare providers must strive to better understand the risk factors associated with CM reactions, as well as the available prophylactic and treatment options. PMID:16454540

  6. On the origin of 150-km echoes: Recent observational results and current understanding

    Science.gov (United States)

    Patra, Amit

    2012-07-01

    Discovered nearly 45 years ago, the so-called 150-km echoing phenomenon continues to be a puzzle. These are the coherent radar echoes coming from the height region of 140-180 km during daytime and are of special interest to the ionospheric scientists since they are very useful means for estimating the daytime electric fields, a crucial parameter for studying daytime electrodynamics and plasma physics, and can be observed by radar with moderate sensitivity. Although the 150-km echoes are being regularly used for studying low latitude electrodynamics, it is a bit awkward using them in the scientific work without knowing their origin. This paper is meant to present and discuss new results obtained from Gadanki (13.5o N, 79.2o E, mag. lat. 6.5o N), India to elucidate the underlying physical processes, not considered before. Two new findings, one obtained during the passage of a solar eclipse and another linked with the intermediate layer type descending properties of 150-km echoes, clearly indicate the role of electron density gradient in generating the irregularities responsible for the 150-km radar echoes, not envisioned before. Given the fact that Gadanki is located at magnetically low latitude, it is proposed that the descending echoing layers are produced by interchange instability on the gradient of daytime descending ion layer formed by meridional wind shear associated with tidal/gravity waves quite similar to that observed during nighttime. Comparative anatomy of daytime 150-km echoes and nighttime intermediate layer echoes will also be presented and discussed in an effort to have a deeper understanding on the underlying instability processes.

  7. The Solar Wind: Our Current Understanding and How We Got Here

    Indian Academy of Sciences (India)

    Joseph V. Hollweg

    2008-03-01

    In the original theory for the solar wind, the electron pressure gradient was the principal accelerating force. This was soon recognized to be insufficient to drive the high-speed streams. Subsequently, the discovery of Alfvén waves in the solar wind led to a long series of models in which wave pressure provided additional acceleration, but these wave-driven models ultimately failed to explain the rapid acceleration of the fast wind close to the Sun. An alternate viewwas that the pressure of hot protons close to the Sun could explain the rapid acceleration, with the proton heating coming from the cyclotron resonance. SOHO has provided remarkable data which have verified some of the predictions of this view, and given impetus to ongoing studies of the ion-cyclotron resonance in the fast wind. After a historical review, we discuss the basic ideas behind current research, emphasizing the importance of particle kinetics. We conclude with some guesses as to how work might proceed in the future.

  8. Acute kidney injury following cardiac surgery: current understanding and future directions.

    Science.gov (United States)

    O'Neal, Jason B; Shaw, Andrew D; Billings, Frederic T

    2016-01-01

    Acute kidney injury (AKI) complicates recovery from cardiac surgery in up to 30 % of patients, injures and impairs the function of the brain, lungs, and gut, and places patients at a 5-fold increased risk of death during hospitalization. Renal ischemia, reperfusion, inflammation, hemolysis, oxidative stress, cholesterol emboli, and toxins contribute to the development and progression of AKI. Preventive strategies are limited, but current evidence supports maintenance of renal perfusion and intravascular volume while avoiding venous congestion, administration of balanced salt as opposed to high-chloride intravenous fluids, and the avoidance or limitation of cardiopulmonary bypass exposure. AKI that requires renal replacement therapy occurs in 2-5 % of patients following cardiac surgery and is associated with 50 % mortality. For those who recover from renal replacement therapy or even mild AKI, progression to chronic kidney disease in the ensuing months and years is more likely than for those who do not develop AKI. Cardiac surgery continues to be a popular clinical model to evaluate novel therapeutics, off-label use of existing medications, and nonpharmacologic treatments for AKI, since cardiac surgery is fairly common, typically elective, provides a relatively standardized insult, and patients remain hospitalized and monitored following surgery. More efficient and time-sensitive methods to diagnose AKI are imperative to reduce this negative outcome. The discovery and validation of renal damage biomarkers should in time supplant creatinine-based criteria for the clinical diagnosis of AKI. PMID:27373799

  9. Polar mesosphere summer echoes (PMSE: Review of observations and current understanding

    Directory of Open Access Journals (Sweden)

    M. Rapp

    2004-01-01

    Full Text Available Polar mesosphere summer echoes (PMSE are very strong radar echoes primarily studied in the VHF wavelength range from altitudes close to the polar summer mesopause. Radar waves are scattered at irregularities in the radar refractive index which at mesopause altitudes is effectively determined by the electron number density. For efficient scatter, the electron number density must reveal structures at the radar half wavelength (Bragg condition for monostatic radars; ~3 m for typical VHF radars. The question how such small scale electron number density structures are created in the mesopause region has been a longstanding open scientific question for almost 30 years. This paper reviews experimental and theoretical milestones on the way to an advanced understanding of PMSE. Based on new experimental results from in situ observations with sounding rockets, ground based observations with radars and lidars, numerical simulations with microphysical models of the life cycle of mesospheric aerosol particles, and theoretical considerations regarding the diffusivity of electrons in the ice loaded complex plasma of the mesopause region, a consistent explanation for the generation of these radar echoes has been developed. The main idea is that mesospheric neutral air turbulence in combination with a significantly reduced electron diffusivity due to the presence of heavy charged ice aerosol particles (radii ~5–50 nm leads to the creation of structures at spatial scales significantly smaller than the inner scale of the neutral gas turbulent velocity field itself. Importantly, owing to their very low diffusivity, the plasma structures acquire a very long lifetime, i.e., 10 min to hours in the presence of particles with radii between 10 and 50 nm. This leads to a temporal decoupling of active neutral air turbulence and the existence of small scale plasma structures and PMSE and thus readily explains observations proving the absence of neutral air turbulence at

  10. Understanding the mental health of youth living with perinatal HIV infection: lessons learned and current challenges

    Directory of Open Access Journals (Sweden)

    Kathleen M Malee

    2013-06-01

    limitations that preclude both conclusions and full understanding of aetiology. Conversely, these limitations present opportunities for future research. Many PHIV+ youth experience adequate mental health despite vulnerabilities. However, the focus of research to date highlights the identification of risks rather than positive attributes, which could inform preventive interventions. Development and evaluation of mental health interventions and preventions are urgently needed to optimize mental health, particularly for PHIV+ youth growing up in low-and-middle income countries.

  11. Development and Current Status of National Cancer Center for Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    LI Jie; LIN Hong-sheng; HOU Wei; ZHANG Pei-tong; HUA Bao-jin

    2011-01-01

    @@ Chinese medicine (CM) is an important feature of cancer treatment in China.Especially in the last 10years, the effect of CM in cancer treatment has been of high concern and has been accepted by experts and patients locally and overseas.The oncology department (OD) of Guang'anmen Hospital (GAMH) of China Academy of Chinese Medical Sciences (CATCM),which will mark its 50th anniversary in 2013, is one of China's most-respected centers devoted exclusively to cancer patient care, research, education, and prevention through CM.It is located at the campus of GAMH,central Beijing.

  12. Current Development of Nuclear Thermal Propulsion technologies at the Center for Space Nuclear Research

    Energy Technology Data Exchange (ETDEWEB)

    Robert C. O' Brien; Steven K. Cook; Nathan D. Jerred; Steven D. Howe; Ronald Samborsky; Daniel Brasuell

    2012-09-01

    Nuclear power and propulsion has been considered for space applications since the 1950s. Between 1955 and 1972 the US built and tested over twenty nuclear reactors / rocket engines in the Rover/NERVA programs1. The Aerojet Corporation was the prime contractor for the NERVA program. Modern changes in environmental laws present challenges for the redevelopment of the nuclear rocket. Recent advances in fuel fabrication and testing options indicate that a nuclear rocket with a fuel composition that is significantly different from those of the NERVA project can be engineered; this may be needed to ensure public support and compliance with safety requirements. The Center for Space Nuclear Research (CSNR) is pursuing a number of technologies, modeling and testing processes to further the development of safe, practical and affordable nuclear thermal propulsion systems.

  13. [Current aspects of war surgery. From the trauma center to precarious medical care].

    Science.gov (United States)

    Houdelette, P

    1997-01-01

    War, said Carl von Clausewitz, is a cameleon. In this century, each armed conflict has proved to be unique, particularly in its medical aspects, with its own features and teaching its won lessons. As recent events show, no conflict is a fact of the past. Medical care delivered to war casualties depend on the circumstances of the war, on the medical resources available, but also on the price that cultures or circumstances place on it. Everything separates these two paradigms; on the one hand the "precious" casualty of western armies whose medical support is organized in a concept (forward medical and surgical care, ultra-rapid medical evacuation) tailored to each case, and as close as possible to the medical care of a civilian trauma patient whose models remains the North-American ballistic wound managed in trauma centers; on the other hand, civilian victims, in large numbers, in poor and disorganized countries, often abandoned to their own fate or sorted by "epidemiological" triage, which guarantees a distribution, as efficient as possible, of limited medical care. In war, advanced medical care and precarious medicine may work side by side according to two logics which do not exclude one another and constantly improve. PMID:9297902

  14. How Do We Understand Children’s Restlessness? A Critique of the Biopsychosocial Model and ADHD as the Dominating Perspective in Current Understanding and Treatment

    Directory of Open Access Journals (Sweden)

    Anna Helle-Valle

    2014-03-01

    Full Text Available How is children’s restlessness understood and handled by surrounding adults? Two approaches are outlined in this article: one is the biomedical and later the biopsychosocial model, the other is a tradition that can be traced back to Foucault’s concept of historical ontology. The biopsychosocial model and ADHD is currently the dominating perspective when it comes to describing, understanding and treating restlessness in children. In this tradition, a focus on pathology and biology places the root of the problem within the child and positions the surrounding adults as neutral observers and helpers. By contrast, historical ontology opens up to questions about the neutrality and validity of a biopsychosocial approach by pointing to our active role as subjects in creating ideas of truth about children, in judging their behaviour and in “helping” them. Rather than claiming that one approach is better than the other, it can be useful to regard the two traditions as providing different levels of analysis and be aware of the possibilities and limitations pertaining to these.

  15. Josephson junctions with centered step and local variation of critical current density

    OpenAIRE

    Weides, M.

    2009-01-01

    Superconductor-insulator-ferromagnet-superconductor (SIFS) Josephson tunnel junctions based on Nb\\Al2O3\\Ni\\Cu\\Nb stacks with a thickness step in the metallic NiCu interlayer were fabricated. The step height of a few 0.1 nm was defined by optical lithography and controlled etching of both Nb and NiCu layers. Experimentally determined junction parameters by current-voltage characteristics and Fraunhofer pattern indicate a uniform NiCu thickness and similar interface transparencies for etched an...

  16. Video and Visualization to Communicate Current Geoscience at Museums and Science Centers

    Science.gov (United States)

    Allen, L.; Trakinski, V.; Gardiner, N.; Foutz, S.; Pisut, D.

    2012-12-01

    Science Bulletins, a current-science video exhibition program produced by the American Museum of Natural History, was developed to communicate scientific concepts and results to a wide public and educator audience. Funded by a NOAA Environmental Literacy Grant and developed in collaboration with scientists, a series of Science Bulletins pieces mixes data visualization, video, and non-narrated text to highlight recent issues and findings relevant to short and long-term change in the Earth system. Some of the pieces have been evaluated with audiences to assess learning outcomes and improve practices. Videos, evaluation results, and multiplatform dissemination strategies from this series will be shared and discussed.

  17. One View of the Current State of Understanding in Basal Ganglia Pathophysiology and What is Needed for the Future

    Directory of Open Access Journals (Sweden)

    Erwin B. Montgomery

    2011-05-01

    Full Text Available Deep Brain Stimulation (DBS, arguably, is the most dramatic development in movement disorders since the levodopa for Parkinson’s disease. Yet, its mechanisms of action of DBS are unknown. However, DBS related research already has demonstrated that current concepts of basal ganglia pathophysiology are wrong. Specifically, the notion that over-activity of the globus pallidus interna causes parkinsonism, the basis for the most current theories, is no longer tenable. The development of any new theory will be aided by an understanding of how current theories are wrong and why have these flawed theories persist. Many of the problems of current theories are more matters of inference, assumptions, presumptions, and the accepted level of ambiguity than they are of fact. Consequently, it is imperative that these issues be addressed. Just as the inappropriate use of a tool or method is grounds for criticism, methods of reasoning are tools that can be used inappropriately and should be subject to discussion just as misuse of any other tool. Thorough criticism can provide very important lesions though the process could be mistaken as harsh or personal; neither is the case here. At the least, such analyzes can point to potential pitfalls that could be avoided in the development of new theories. As will be discussed, theories are important for the development of therapies but perhaps most important, for the acceptance of new therapies, as was the case for the recent resurgence of interest in surgical therapies.

  18. The role of the pharmacist in patient-centered medical home practices: current perspectives

    Directory of Open Access Journals (Sweden)

    Lewis NJW

    2014-06-01

    Full Text Available Nancy JW Lewis,1 Leslie A Shimp,2 Stuart Rockafellow,2 Jeffrey M Tingen,2 Hae Mi Choe,3 Marie A Marcelino21Private consultancy practice, Rochester Hills, MI, USA; 2Clinical, Social and Administrative Department, University of Michigan College of Pharmacy, Ann Arbor, MI, USA; 3Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, MI, USAAbstract: Patient-centered medical homes (PCMHs are the centerpiece of primary care transformation in the US. They are intended to improve care coordination and communication, enhance health care quality and patient experiences, and lower health care costs by linking patients to a physician-led interdisciplinary health care team. PCMHs are widely supported by health care associations, payers, and employers. Health care accreditation organizations have created performance measures that promote the adoption of PCMH core attributes. Public and private payers are increasingly providing incentives and bonuses related to performance measure status. Evidence-based prescription, medication adherence, medication use coordination, and systems to support medication safety are all necessary components of PCMHs. Pharmacists have unique knowledge and skills that can complement the care provided by other PCMH team members. Their experience in drug therapy assessments, medication therapy management, and population health has documented benefits, both in terms of patient health outcomes and health care costs. Through collaborative care, pharmacists can assist physicians and other prescribers in medication management and thus improve prescriber productivity and patient access to care. Pharmacists are engaged in PCMHs through both employment and contractual arrangements. While some pharmacists serve a unique PCMH, others work within practice networks that serve practices within a geographical area. Financial support for pharmacist-provided services includes university funding, external grant funding

  19. Current Usage and Future Prospects of Multispectral (RGB) Satellite Imagery in Support of NWS Forecast Offices and National Centers

    Science.gov (United States)

    Molthan, Andrew; Fuell, Kevin; Knaff, John; Lee, Thomas

    2012-01-01

    What is an RGB Composite Image? (1) Current and future satellite instruments provide remote sensing at a variety of wavelengths. (2) RGB composite imagery assign individual wavelengths or channel differences to the intensities of the red, green, and blue components of a pixel color. (3) Each red, green, and blue color intensity is related to physical properties within the final composite image. (4) Final color assignments are therefore related to the characteristics of image pixels. (5) Products may simplify the interpretation of data from multiple bands by displaying information in a single image. Current Products and Usage: Collaborations between SPoRT, CIRA, and NRL have facilitated the use and evaluation of RGB products at a variety of NWS forecast offices and National Centers. These products are listed in table.

  20. Cluster observations of solitary waves near the center of the current sheet in association with magnetic reconnection

    Science.gov (United States)

    Hupach, A.; Cattell, C. A.; Wygant, J. R.; Schwartz, S. J.; Mouikis, C.

    2010-12-01

    Cluster observations of large amplitude solitary waves (up to ~250 mV/m), identified as electron holes, were studied for six days when the satellites repeatedly crossed the plasma sheet near a reconnection region. Examination of EFW instrument burst data, with an automated program [Dombeck et al., 2001] and visual inspection, detected solitary waves on 18 of the 24 bursts. There was one 10 second burst on each spacecraft each day with solitary waves detected in at least one burst from every day. Solitary waves were seen on all four spacecraft during three of the days. The variety of positions surveyed by Cluster due to both spacecraft separation and the differing locations with respect to the reconnection region at each of the six events enables a comparison of solitary wave duration and peak to peak electric field in many different parts of the reconnection region. The study expands work by Cattell et al. [2005] which, along with simulations by Drake et al. [2003], showed that electron holes could provide some of the particle scattering needed in the reconnection process. The August 24, 2003 burst on spacecraft 2 is unique because several solitary waves were detected less than 200 km from and some within a few km of the center of the current sheet (BXgse=0). This is in contrast to the Cattell et al. [2005] results where solitary waves were only seen on spacecraft greater than 1,500 km from the center of the current sheet. Peak to peak electric fields of a few to hundreds of mV/m and durations of tenths to tens of microseconds were consistent for solitary waves both near and far from the center of the current sheet. In agreement with previous studies and independent of position in the current sheet, all solitary waves were detected during times when PEACE measured narrow field aligned electron beams. While recent studies, such as Che et al. [2009] and Goldman et al. [2008], suggested different wave modes for the evolution of solitary waves, a determination of

  1. Current understanding of the processes underlying the triggering of and energy loss associated with type I ELMs

    CERN Document Server

    Kirk, A; Dunne, M; Huijsmans, G; Pamela, S; Becoulet, M; Harrison, J R; Hillesheim, J; Roach, C; Saarelma, S

    2013-01-01

    The type I ELMy H-mode is the baseline operating scenario for ITER. While it is known that the type I ELM ultimately results from the peeling-ballooning instability, there is growing experimental evidence that a mode grows up before the ELM crash that may modify the edge plasma, which then leads to the ELM event due to the peeling-ballooning mode. The triggered mode results in the release of a large number of particles and energy from the core plasma but the precise mechanism by which these losses occur is still not fully understood and hence makes predictions for future devices uncertain. Our current understanding of the processes that trigger type I ELMs and the size of the resultant energy loss are reviewed and compared to experimental data and ideas for further development are discussed.

  2. Understanding the role of electron and hole trions on current transport in aluminium tris(8-hydroxyquinoline) using organic magnetoresistance

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Sijie; Gillin, W. P., E-mail: w.gillin@qmul.ac.uk [College of Physical Science and Technology, Sichuan University, Chengdu 610064 (China); Materials Research Institute and School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); Willis, M. [College of Physical Science and Technology, Sichuan University, Chengdu 610064 (China); Gotto, R.; Roy, K. A.; Kreouzis, T. [Materials Research Institute and School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); Rolfe, N. J. [Materials Research Institute and School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); University of Surrey, Guildford, Surrey GU2 5XH (United Kingdom)

    2014-01-27

    The change in current through an organic light emitting diode (OLED) when it is placed in a magnetic field has been dubbed organic magnetoresistance and provides a means to understand the spin interactions that are occurring in working devices. Whilst there are a wide range of interactions that have been proposed to be the cause of the measured effects, there is still a need to identify their individual roles and in particular how they respond to an applied magnetic field. In this work, we investigate the effect of changing the balance of electron and hole injection in a simple aluminium tris(8-hydroxyqinoline) based OLED and demonstrate that the triplet polaron interaction appears to be much stronger for electrons than for holes in this material.

  3. Review of the current understanding of the potential for containment failure from in-vessel steam explosions

    International Nuclear Information System (INIS)

    A group of experts was convened to review the current understanding of the potential for containment failure from in-vessel steam explosions during core meltdown accidents in LWRs. The Steam Explosion Review Group (SERG) was requested to provide assessments of: (1) the conditional probability of containment failure due to a steam explosion, (2) a Sandia National Laboratory (SNL) report entitled ''An Uncertainty Study of PWR Steam Explosions,'' NUREG/CR-3369, (3) a SNL proposed steam explosion research program. This report summarizes the results of the deliberations of the review group. It also presents the detailed response of each individual member to each of the issues. The consensus of the SERG is that the occurrence of a steam explosion of sufficient energetics which could lead to alpha-mode containment failure has a low probability. The SERG members disagreed with the methodology used in NUREG/CR-3369 for the purpose of establishing the uncertainty in the probability of containment failure by a steam explosion. A consensus was reached among SERG members on the need for a continuing steam explosion research program which would improve our understanding of certain aspects of steam explosion phenomenology

  4. Depairing critical current achieved in superconducting thin films with through-thickness arrays of artificial pinning centers

    International Nuclear Information System (INIS)

    Large area arrays of through-thickness nanoscale pores have been milled into superconducting Nb thin films via a process utilizing anodized aluminum oxide thin film templates. These pores act as artificial flux pinning centers, increasing the superconducting critical current, Jc, of the Nb films. By optimizing the process conditions including anodization time, pore size and milling time, Jc values approaching and in some cases matching the Ginzburg-Landau depairing current of 30 MA cm-2 at 5 K have been achieved-a Jc enhancement over as-deposited films of more than 50 times. In the field dependence of Jc, a matching field corresponding to the areal pore density has also been clearly observed. The effect of backfilling the pores with magnetic material has then been investigated. While backfilling with Co has been successfully achieved, the effect of the magnetic material on Jc has been found to be largely detrimental compared to voids, although a distinct influence of the magnetic material in producing a hysteretic Jc versus applied field behavior has been observed. This behavior has been tested for compatibility with currently proposed models of magnetic pinning and found to be most closely explained by a model describing the magnetic attraction between the flux vortices and the magnetic inclusions.

  5. Current Understanding of Cu-Exchanged Chabazite Molecular Sieves for Use as Commercial Diesel Engine DeNOx Catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Feng; Kwak, Ja Hun; Szanyi, Janos; Peden, Charles HF

    2013-11-03

    Selective catalytic reduction (SCR) of NOx with ammonia using metal-exchanged molecular sieves with a chabazite (CHA) structure has recently been commercialized on diesel vehicles. One of the commercialized catalysts, i.e., Cu-SSZ-13, has received much attention for both practical and fundamental studies. For the latter, the particularly well-defined structure of this zeolite is allowing long-standing issues of the catalytically active site for SCR in metal-exchanged zeolites to be addressed. In this review, recent progress is summarized with a focus on two areas. First, the technical significance of Cu-SSZ-13 as compared to other Cu-ion exchanged zeolites (e.g., Cu-ZSM-5 and Cu-beta) is highlighted. Specifically, the much enhanced hydrothermal stability for Cu-SSZ-13 compared to other zeolite catalysts is addressed via performance measurements and catalyst characterization using several techniques. The enhanced stability of Cu-SSZ-13 is rationalized in terms of the unique small pore structure of this zeolite catalyst. Second, the fundamentals of the catalytically active center; i.e., the chemical nature and locations within the SSZ-13 framework are presented with an emphasis on understanding structure-function relationships. For the SCR reaction, traditional kinetic studies are complicated by intra-particle diffusion limitations. However, a major side reaction, nonselective ammonia oxidation by oxygen, does not suffer from mass-transfer limitations at relatively low temperatures due to significantly lower reaction rates. This allows structure-function relationships that are rather well understood in terms of Cu ion locations and redox properties. Finally, some aspects of the SCR reaction mechanism are addressed on the basis of in-situ spectroscopic studies.

  6. Development of a Student-Centered Instrument to Assess Middle School Students' Conceptual Understanding of Sound

    Science.gov (United States)

    Eshach, Haim

    2014-01-01

    This article describes the development and field test of the Sound Concept Inventory Instrument (SCII), designed to measure middle school students' concepts of sound. The instrument was designed based on known students' difficulties in understanding sound and the history of science related to sound and focuses on two main aspects of…

  7. A systematic review of HIV/AIDS-related stigma and discrimination in India: current understanding and future needs.

    Science.gov (United States)

    Bharat, Shalini

    2011-01-01

    HIV/AIDS-related stigma is recognised as a major barrier to HIV prevention efforts and an impediment to mitigating its impact on individuals and communities. This paper reviews the existing research literature on AIDS stigma in India with the objective of documenting the current status of research, highlighting major findings and identifying key gaps remaining. Thirty publications were identified through a careful search of which a majority focused on stigma assessment and very few on stigma measurement, conceptual aspects of stigma or stigma reduction interventions. A few standardised stigma measures are available but more are required to assess causes of stigma among general population and compounded and internalised stigma among positive people. Research exploring linkages between stigma and HIV services uptake or the effect of HIV care and treatment programs on stigma levels are largely missing and need to be prioritised. In addition, more research is needed to advance conceptual understanding of stigma within the cultural context of the country including research on the neglected groups such as, transgender people. Context-specific (health care, community) interventions are needed to address various forms of stigma - enacted, perceived, internalised and layered - including structural approaches besides inter-personal and information-based approaches. A major gap relates to meager research on developing and evaluating stigma reduction interventions and needs priority focus. Overall, the review recommends developing a national agenda on AIDS stigma research and interventions to help realise the government's goal of stigma reduction. PMID:23237728

  8. Current understanding of treatment and management protocol for adult diabetic in-patients at a tertiary care hospital

    International Nuclear Information System (INIS)

    Objective: To assess the current understanding of treatment and management protocols for adult diabetic in-patients at a tertiary care hospital. Methods: This cross-sectional study, conducted at the Civil Hospital Karachi from July to September 2009, involved 450 participants, who were interviewed through a well-structured questionnaire regarding the patient's demography, clinical features, past medical history, type of diabetes mellitus, duration, associated complications, and also involved patient notes for laboratory tests and management. SPSSv15.0 was used for descriptive analysis. Results: The study population of 450 diabetics had 144 (32%) males and 306 (68%) females. Of the total, 435 (96.7%) patients had type 2 diabetes. There were 231 (51%) patients using insulin, 168 (37.3%) oral hypoglycaemic drugs, and 51 (11.3%) using both. Among patients using insulin, regular insulin usage stood at 30% followed by a combination of regular insulin and NPH (26.7%) and NPH alone at 6%. The most popular drug used was metformin (27.3%) and the least used drug was glitazones (4%). In the study population, 73.3% patients controlled their diabetes with diet, and 24.7% with regular exercise. Conclusion: Majority of the study population had type 2 diabetes with a female preponderance. Insulin was prescribed for half the patients. Metformin was the most frequently used oral hypoglycaemic drug. (author)

  9. Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer.

    Science.gov (United States)

    Haque, Absarul; Alam, Qamre; Alam, Mohammad Zubair; Azhar, Esam I; Sait, Khalid Hussain Wali; Anfinan, Nisrin; Mushtaq, Gohar; Kamal, Mohammad Amjad; Rasool, Mahmood

    2016-01-01

    Heat Shock Protein 90 (HSP90) is a ubiquitous molecular chaperone that is considered to be the most abundantly expressed protein in various human cancers such as breast, lung, colon, prostate, leukemia and skin. The master regulator, HSP90 plays a pivotal role in the conformational stabilization, maturation and activity of its various labile oncogenic client proteins such as p53, ErbB2, Bcr-Abl, Akt, Her-2, Cdk4, Cdk6, Raf-1 and v-Src in altered cells. Hence, making a guaranteed attempt to inhibit such a master regulator for cancer therapy appears to be a potential approach for combinatorial inhibition of numerous oncogenic signaling pathways simultaneously. Considerable efforts are being under way to develop novel molecular targets and its inhibitors that may block key signaling pathways involved in the process of tumorigenesis and metastasis. In this regards, HSP90 has acquired immense interest as a potent anticancer drug-target due to its key functional link with multiple signaling pathways involved in the process of cell proliferation and cell survival. Notably, geldanamycin and its derivatives (17-AAG, 17-DMAG) have shown quite encouraging results in inhibiting HSP90 function in several cancers and currently almost 17 drug candidates known to be target HSP90 are being under clinical trials either as single agents or combinatorial therapy. Hence, this review is an attempt to get new insight into novel drug target therapy by focusing on recent advances made in understanding HSP90 chaperone structure-function relationships, identification of new HSP90 client proteins and, more importantly, on the advancements of HSP90 targeted therapy based on various existing and emerging classical inhibitors. PMID:27013225

  10. Current situation of sexual and reproductive health of men deprived of liberty in the Institutional Care Center of San Jose

    Directory of Open Access Journals (Sweden)

    Dorita Rivas Fonseca

    2013-10-01

    Full Text Available The objective of this research was to determine the current status of the issue of sexual and reproductive health ofthe prisoners Institutional Care Center (CAI of San Jose. It is a descriptive study. Through a strategic samplingdetermined the participation of 102 men. The information was obtained by applying a self-administeredquestionnaire with closed and open questions. As a result relevant to your socio-demographic profile, it appearsthat deprived of their liberty is a very heterogeneous group. As regards sexual and reproductive health, the firstconcept they relate to the prevention of disease and the second reproductive aspects, this shows limitations inknowledge on the topics, something that affects the daily life activities and self-care. It is concluded that researchby nurses Gyneco-obstetric in the deprived of liberty is almost null not only in the country but in the world,especially if it comes with the male population. In the case of CAI Prison, health care is not enough for thenumber of inmates who inhabit (overpopulation of almost 50%, this implies a deterioration in health and physicalcondition of these people, as well as sexual and reproductive health

  11. An Overview of Current Capabilities and Research Activities in the Airspace Operations Laboratory at NASA Ames Research Center

    Science.gov (United States)

    Prevot, Thomas; Smith, Nancy M.; Palmer, Everett; Callantine, Todd; Lee, Paul; Mercer, Joey; Homola, Jeff; Martin, Lynne; Brasil, Connie; Cabrall, Christopher

    2014-01-01

    The Airspace Operations Laboratory at NASA Ames conducts research to provide a better understanding of roles, responsibilities, and requirements for human operators and automation in future air traffic management (ATM) systems. The research encompasses developing, evaluating, and integrating operational concepts and technologies for near-, mid-, and far-term air traffic operations. Current research threads include efficient arrival operations, function allocation in separation assurance and efficient airspace and trajectory management. The AOL has developed powerful air traffic simulation capabilities, most notably the Multi Aircraft Control System (MACS) that is used for many air traffic control simulations at NASA and its partners in government, academia and industry. Several additional NASA technologies have been integrated with the AOL's primary simulation capabilities where appropriate. Using this environment, large and small-scale system-level evaluations can be conducted to help make near-term improvements and transition NASA technologies to the FAA, such as the technologies developed under NASA's Air Traffic Management Demonstration-1 (ATD-1). The AOL's rapid prototyping and flexible simulation capabilities have proven a highly effective environment to progress the initiation of trajectory-based operations and support the mid-term implementation of NextGen. Fundamental questions about accuracy requirements have been investigated as well as realworld problems on how to improve operations in some of the most complex airspaces in the US. This includes using advanced trajectory-based operations and prototype tools for coordinating arrivals to converging runways at Newark airport and coordinating departures and arrivals in the San Francisco and the New York metro areas. Looking beyond NextGen, the AOL has started exploring hybrid human/automation control strategies as well as highly autonomous operations in the air traffic control domain. Initial results

  12. One View of the Current State of Understanding in Basal Ganglia Pathophysiology and What is Needed for the Future

    OpenAIRE

    Montgomery, Erwin B.

    2011-01-01

    Deep Brain Stimulation (DBS), arguably, is the most dramatic development in movement disorders since the levodopa for Parkinson’s disease. Yet, its mechanisms of action of DBS are unknown. However, DBS related research already has demonstrated that current concepts of basal ganglia pathophysiology are wrong. Specifically, the notion that over-activity of the globus pallidus interna causes parkinsonism, the basis for the most current theories, is no longer tenable. The development of any new t...

  13. Final Technical Report for the Energy Frontier Research Center Understanding Charge Separation and Transfer at Interfaces in Energy Materials (EFRC:CST)

    Energy Technology Data Exchange (ETDEWEB)

    Vanden Bout, David A. [Univ. of Texas, Austin, TX (United States)

    2015-09-14

    Our EFRC was founded with the vision of creating a broadly collaborative and synergistic program that would lead to major breakthroughs in the molecular-level understanding of the critical interfacial charge separation and charge transfer (CST) processes that underpin the function of candidate materials for organic photovoltaic (OPV) and electrical-energy-storage (EES) applications. Research in these energy contexts shares an imposing challenge: How can we understand charge separation and transfer mechanisms in the presence of immense materials complexity that spans multiple length scales? To address this challenge, our 50-member Center undertook a total of 28 coordinated research projects aimed at unraveling the CST mechanisms that occur at interfaces in these nanostructured materials. This rigorous multi-year study of CST interfaces has greatly illuminated our understanding of early-timescale processes (e.g., exciton generation and dissociation dynamics at OPV heterojunctions; control of Li+-ion charging kinetics by surface chemistry) occurring in the immediate vicinity of interfaces. Program outcomes included: training of 72 graduate student and postdoctoral energy researchers at 5 institutions and spanning 7 academic disciplines in science and engineering; publication of 94 peer-reviewed journal articles; and dissemination of research outcomes via 340 conference, poster and other presentations. Major scientific outcomes included: implementation of a hierarchical strategy for understanding the electronic communication mechanisms and ultimate fate of charge carriers in bulk heterojunction OPV materials; systematic investigation of ion-coupled electron transfer processes in model Li-ion battery electrode/electrolyte systems; and the development and implementation of 14 unique technologies and instrumentation capabilities to aid in probing sub-ensemble charge separation and transfer mechanisms.

  14. Building a shared understanding of the skills and competences in order to respond to the current global technical challenges

    DEFF Research Database (Denmark)

    Friesel, Anna; Ward, Anthony; Welzer, Tatjana;

    2014-01-01

    current challenges. This paper presents the objectives and actual results of the EU supported project which runs from October 2012 to November 2015, named SALEIE - Strategic Alignment of Electrical and Information Engineering in European Higher Education Institutions. We describe in this paper the...

  15. Understanding Alzheimer's Disease

    Science.gov (United States)

    ... Referral Center Alzheimer's Disease Education and Referral Center Alzheimer's Disease Education and Referral Center Home About Alzheimer’s ... National Alzheimer's Project Act (NAPA) About ADEAR Understanding Alzheimer's Disease: What You Need to Know Introduction Many ...

  16. A summary of current understanding regarding children with autism spectrum disorder who are deaf or hard of hearing.

    Science.gov (United States)

    Szarkowski, Amy; Mood, Deborah; Shield, Aaron; Wiley, Susan; Yoshinaga-Itano, Christine

    2014-11-01

    This article provides a consensus perspective based on the authors' expertise and the limited available literature regarding our understanding of children with an autism spectrum disorder (ASD) who are deaf or hard of hearing (D/HH). The challenges in the accurate identification of an ASD in children who are D/HH, including red flags for a potential ASD and screening and assessment for ASD, are described in this article. Additionally, strategies to guide professionals in their communication about a possible ASD with families and to frame the need for expanding aspects of communication important for this group of children are suggested. PMID:25321849

  17. Current understanding of cellulose ethers impact on the hydration of C3A and C3A-sulphate systems

    OpenAIRE

    Pourchez, Jérémie; Grosseau, Philippe; Ruot, Bernard

    2009-01-01

    The impact of cellulose ethers (CE) on C3A hydration was examined to support the understanding of the retarding effect of CE on cement hydration. In this sense, we successively studied the CE adsorption on ettringite and calcium hydroaluminates, and then the CE influence during C3A hydration in presence or absence of calcium sulphate. We emphasized a phase-specific adsorption of CE depending on CE chemistry. Besides, in addition of CE, we highlighted a gradual slowing down of C3A dissolution ...

  18. The current state of Contract Law in Australia and why it is important for rural managers to understand it

    OpenAIRE

    Smith, Tony

    2011-01-01

    Farmers are business managers and as such they must understand the law or they are likely to fall foul of it. This especially applies to contract law, with which they deal constantly. Contract law is made up of the common law – as the courts have decided it – and statute law- as the state and federal parliaments have enacted statutes which modify the common law. The most important and most recent of the latter is the new Australian Consumer Law.

  19. Developing a theoretical framework for understanding (staged) authentic retail concepts in relation to the current experience economy

    OpenAIRE

    Plevoets, Bie; Petermans, Ann; VAN CLEEMPOEL, Koenraad

    2010-01-01

    In the current experience economy, some retailers and retail designers aim at triggering customer experiences by associating the retail store?s design with „authenticity?. The notion of authenticity, however, is complex and layered and has been studied in several scientific disciplines. But within retail design, only limited research on authenticity is available. This paper aims to clarify the complex concept of authenticity in relation to retail design. Retail design as part of interior arch...

  20. International Veterinary Epilepsy Task Force's current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs

    DEFF Research Database (Denmark)

    Hülsmeyer, Velia-Isabel; Fischer, Andrea; Mandigers, Paul J. J.; DeRisio, Luisa; Berendt, Mette; Rusbridge, Clare; Bhatti, Sofie F. M.; Pakozdy, Akos; Patterson, Edward E.; Platt, Simon; Packer, Rowena M. A.; Volk, Holger A.

    2015-01-01

    Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in...... the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and...... highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted....

  1. The role of B B Kadomtsev's ideas in shaping the current understanding of turbulent transport

    International Nuclear Information System (INIS)

    B B Kadomtsev's turbulent diffusion models are reviewed. Some of the current approaches to describing 'long-range correlation' effects are presented that are directly based on B B Kadomtsev's ideas (diffusion renormalization of quasilinear equations, the percolation approach to strong turbulence, stochastic instability and the transverse diffusion of plasma particles as factors affecting transport in a 'braided' magnetic field). It is shown that B B Kadomtsev's analytical methods have great heuristic power and will undoubtedly influence the further development of turbulent transport theory. (from the history of physics)

  2. An analysis of current treatment practice in uterine papillary serous and clear cell carcinoma at two high volume cancer centers

    OpenAIRE

    Vogel, Tilley Jenkins; Knickerbocker, Abhay; Shah, Chirag A.; Schiff, Melissa A.; Isacson, Christina; Garcia, Rochelle L; Goff, Barbara A.

    2015-01-01

    Objective Despite the rarity of uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCCC), they contribute disproportionately to endometrial cancer deaths. Sufficient clinical information regarding treatment and prognosis is lacking. The aim of this study is to evaluate treatment outcomes in a rare cancer cohort based on the experience at two tertiary care cancer centers. Methods Clinicopathologic data were retrospectively collected on 279 patients with UPSC and UCCC t...

  3. Understanding the molecular target therapy and it's approved synchronous use with radiation therapy in current Indian oncology practice

    International Nuclear Information System (INIS)

    The molecular targeted drugs (MTD) are of two types; large and small. The large molecular targeted drugs (LMTD) cannot cross the cancer cell membrane whereas those that cross the cancer cell membrane are nicknamed small molecular target drugs (SMTD). India has availability of almost all MTD originals approved by USA Food and Drug administration. However a few LMTD like inj vectibix, inj Zevalin, Inj Bexar etc.; and SMTD like cap Tipifarnib approved for AML, are not available in India currently although approved and available in USA. The MTD may he used alone as singlet; along with chemotherapy as doublet or triplet; or along with radiation and chemotherapy combo (nicknamed chemo-radiation-bio therapy). The molecular target therapy approved by USA and/or European FDA and currently available in India and used along with radiation therapy with or without chemotherapy, indication wise are; Brain Tumor Inj Nimotuzumab (LMTD) and Inj bevacizumab (LMTD) in Glioblasoma Multiforme; for Carcinoma Head and neck Inj Cetuximab and Inj Nimotuzumab (LMTT), Tab Geftinib (SMTD). (author)

  4. Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities

    Directory of Open Access Journals (Sweden)

    Todd C Rideout

    2008-10-01

    Full Text Available Todd C Rideout1, Scott V Harding1, Peter JH Jones1, Ming Z Fan21Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada; 2Centre for Nutrition Modeling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, CanadaAbstract: The hypocholesterolemic effects associated with soluble fiber consumption are clear from animal model and human clinical investigations. Moreover, the modulation of whole-body cholesterol metabolism in response to dietary fiber consumption, including intestinal cholesterol absorption and fecal sterol and bile acid loss, has been the subject of many published reports. However, our understanding of how dietary fibers regulate molecular events at the gene/protein level and alter cellular cholesterol metabolism is limited. The modern emphasis on molecular nutrition and rapid progress in ‘high-dimensional’ biological techniques will permit further explorations of the role of genetic polymorphisms in determining the variable interindividual responses to soluble fibers. Furthermore, with traditional molecular biology tools and the application of ‘omic’ technology, specific insight into how fibers modulate the expression of genes and proteins that regulate intestinal cholesterol absorption and alter hepatic sterol balance will be gained. Detailed knowledge of the molecular mechanisms by which soluble fibers reduce plasma cholesterol concentrations is paramount to developing novel fiber-based “cocktails” that target specific metabolic pathways to gain maximal cholesterol reductions.Keywords: dietary fiber, cholesterol, bile acids, gene, protein

  5. Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities

    Directory of Open Access Journals (Sweden)

    Todd C Rideout

    2008-08-01

    Full Text Available Todd C Rideout1, Scott V Harding1, Peter JH Jones1, Ming Z Fan21Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada; 2Centre for Nutrition Modeling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, CanadaAbstract: The hypocholesterolemic effects associated with soluble fiber consumption are clear from animal model and human clinical investigations. Moreover, the modulation of whole-body cholesterol metabolism in response to dietary fiber consumption, including intestinal cholesterol absorption and fecal sterol and bile acid loss, has been the subject of many published reports. However, our understanding of how dietary fibers regulate molecular events at the gene/protein level and alter cellular cholesterol metabolism is limited. The modern emphasis on molecular nutrition and rapid progress in ‘high-dimensional’ biological techniques will permit further explorations of the role of genetic polymorphisms in determining the variable interindividual responses to soluble fibers. Furthermore, with traditional molecular biology tools and the application of ‘omic’ technology, specific insight into how fibers modulate the expression of genes and proteins that regulate intestinal cholesterol absorption and alter hepatic sterol balance will be gained. Detailed knowledge of the molecular mechanisms by which soluble fibers reduce plasma cholesterol concentrations is paramount to developing novel fiber-based “cocktails” that target specific metabolic pathways to gain maximal cholesterol reductions.Keywords: dietary fiber, cholesterol, bile acids, gene, protein

  6. Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair.

    Science.gov (United States)

    Goichberg, Polina

    2016-08-01

    With the advancements in the field of adult stem and progenitor cells grows the recognition that the motility of primitive cells is a pivotal aspect of their functionality. There is accumulating evidence that the recruitment of tissue-resident and circulating cells is critical for organ homeostasis and effective injury responses, whereas the pathobiology of degenerative diseases, neoplasm and aging, might be rooted in the altered ability of immature cells to migrate. Furthermore, understanding the biological machinery determining the translocation patterns of tissue progenitors is of great relevance for the emerging methodologies for cell-based therapies and regenerative medicine. The present article provides an overview of studies addressing the physiological significance and diverse modes of stem and progenitor cell trafficking in adult mammalian organs, discusses the major microenvironmental cues regulating cell migration, and describes the implementation of live imaging approaches for the exploration of stem cell movement in tissues and the factors dictating the motility of endogenous and transplanted cells with regenerative potential. PMID:27209167

  7. The Center for Intercultural Formation, Cuernavaca, Mexico, its reports (1962-1967 and Illich’s critical understanding of mission in Latin America

    Directory of Open Access Journals (Sweden)

    Bruno-Jofré, Rosa

    2014-12-01

    Full Text Available This paper examines the Reports of the Center for Intercultural Formation (CIF, which were produced in Cuernavaca, Mexico, between 1962-1967 by the Centro de Investigaciones Culturales (Center for Cultural Research (CIC, and supported since 1963 by the Centro Intercultural de Documentación (Center for Intercultural Documentation (CIDOC (an offshoot of CIC. The network is placed within the historical conjuncture of the early 1960s and the alignment of the Vatican with the Alliance for Progress and its anti-communist developmentalist community projects. The core of the paper centers in the ‘illocutionary force’ (Quentin Skinner behind Illich’s responses to John XXIII’s call to congregations and lay Catholics for a renewed mission in Latin America. It addresses Illich’s resignification of the understanding of mission and missioner rooted in the Gospel, the notion of incarnation in the culture rather than missioners being agents of their culture, and missionary “poverty” as a virtue of the community worker. Illich’s radicalization of his critical discourse led to a confrontation with the Vatican in 1967 and 1968 after he published “The Seamy Side of Charity” and “The Vanishing Clergyman” in the last year, 1967, of the CIF Report. The conflict with the Vatican signaled Illich’s turn to educational, health and other issues moving away from a critique of the institutionalized Catholic Church.Este artículo examina los Reports del Center of Intercultural Formation (CIF que fueron elaborados en Cuernavaca, México, entre 1962 y 1967 por el Centro de Investigaciones Culturales (CIC, y producidos desde 1963 por el Centro Intercultural de Documentación constituido dentro del CIC. Esta red de centros es situada dentro de la coyuntura histórica del principio de los años sesenta y de la convergencia entre el Vaticano y la Alianza para el Progreso y sus proyectos comunitarios desarrollistas. El artículo se centra en la

  8. Our current understanding of the pathophysiology of equine endometritis with an emphasis on breeding-induced endometritis.

    Science.gov (United States)

    Troedsson, Mats H T; Woodward, Elizabeth M

    2016-03-01

    Equine endometritis is characterized by the expression of pro- and anti- inflammatory cytokines and an influx of polymorphonuclear neutrophils (PMNs) into the uterus. Mares resistant to persistent endometritis clear the inflammation within 24-36h after exposure to microorganisms or semen. These mares have a rapid increase of pro-inflammatory cytokines and an upregulation of inflammatory modulating cytokines within 6h after exposure to inflammatory challenge. In conjunction with effective uterine contractions, these events are believed to be responsible for the transient nature of the inflammation. In contrast, mares that are susceptible to persistent endometritis fail to clear the inflammation in a timely fashion. They have an imbalanced endometrial mRNA expression of pro- and anti-inflammatory cytokines, and have also been shown to suffer from an accumulation of intraluminal nitric oxide, which may be related to impaired myoelectrical activity and delayed uterine clearance. As a consequence, these mares establish a chronic inflammation, which interferes with the establishment of pregnancy. Recent studies on endometrial cytokine expression in resistant and susceptible mares have revealed information that suggest an underlying immunologic basis for susceptibility to persistent endometritis. However, the inflammatory pathways have yet not been fully studied, and a relationship between cytokine expression, nitric oxide, and myometrial contractions has not been established. In addition, seminal plasma has been shown to modulate breeding induced inflammation, but the molecular basis of the modulation is not understood. A holistic approach appears to be needed to better understand the characteristics of inflammatory pathways and ultimately the pathophysiology of the disease. PMID:26952748

  9. Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Elena Bellavista

    2014-01-01

    Full Text Available The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells. As ubiquitin-proteasome system plays a critical role in the regulation of the immune system, it might also influence the development and progression of multiple sclerosis (MS. Both ex vivo analyses and animal models suggest that activity and composition of ubiquitin-proteasome system are altered in MS. Proteasome isoforms endowed of immunosubunits may affect the functionality of different cell types such as CD8+ and CD4+ T cells and B cells as well as neurons during MS development. Furthermore, the study of proteasome-related biomarkers, such as proteasome antibodies and circulating proteasomes, may represent a field of interest in MS. Proteasome inhibitors are already used as treatment for cancer and the recent development of inhibitors selective for immunoproteasome subunits may soon represent novel therapeutic approaches to the different forms of MS. In this review we describe the current knowledge on the potential role of proteasomes in MS and discuss the pro et contra of possible therapies for MS targeting proteasome isoforms.

  10. Toward Understanding the Role of Aryl Hydrocarbon Receptor in the Immune System: Current Progress and Future Trends

    Directory of Open Access Journals (Sweden)

    Hamza Hanieh

    2014-01-01

    Full Text Available The immune system is regulated by distinct signaling pathways that control the development and function of the immune cells. Accumulating evidence suggest that ligation of aryl hydrocarbon receptor (Ahr, an environmentally responsive transcription factor, results in multiple cross talks that are capable of modulating these pathways and their downstream responsive genes. Most of the immune cells respond to such modulation, and many inflammatory response-related genes contain multiple xenobiotic-responsive elements (XREs boxes upstream. Active research efforts have investigated the physiological role of Ahr in inflammation and autoimmunity using different animal models. Recently formed paradigm has shown that activation of Ahr by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or 3,3′-diindolylmethane (DIM prompts the differentiation of CD4+Foxp3+ regulatory T cells (Tregs and inhibits T helper (Th-17 suggesting that Ahr is an innovative therapeutic strategy for autoimmune inflammation. These promising findings generate a basis for future clinical practices in humans. This review addresses the current knowledge on the role of Ahr in different immune cell compartments, with a particular focus on inflammation and autoimmunity.

  11. Understanding performance limitation and suppression of leakage current or self-discharge in electrochemical capacitors: a review.

    Science.gov (United States)

    Ike, Innocent S; Sigalas, Iakovos; Iyuke, Sunny

    2016-01-14

    Self-discharge is known to have considerable adverse effects on the performance and application of electrochemical capacitors (ECs). Thus, obtaining an understanding of EC self-discharge mechanism(s) and subsequent derivation and solution of EC models, subject to a particular mechanism or combination of mechanisms during charging, discharging and storage of the device, is the only way to solve problems associated with EC self-discharge. In this review, we summarize recent progress with respect to EC self-discharge by considering the two basic types, electric double-layer capacitors (EDLC) and pseudocapacitors, and their hybrids with their respective charge storage mechanisms, distinguishable self-discharge mechanisms, charge redistribution and charge/energy loss during self-discharge. It was clearly observed that most of the voltage reduction is not purely due to the self-discharge effect but is basically due to redistribution of charge carriers deep inside pores and can therefore be retrieved from a capacitor during long-time discharging. Tuning the self-discharge rate is therefore feasible for single-walled carbon nanotube (SWNT) ECs and can be achieved by simply adjusting the surface chemistry of the nanotubes. The effects of surface chemistry modification on EC self-discharge are very important in studying and suppressing the self-discharge process and will benefit potential applications of ECs with respect to energy retention. Self-discharge can be averted by the use of redox couples that are transformed to insoluble species via electrolysis and adsorbed onto the activated carbon electrode in redox-couple EDLCs, thus transforming the EDLC electrolyte into a material that can store charge. Self-discharge in ECs can also be successfully suppressed by utilizing an ion-interchange layer (ion-exchange membrane), separator or CuSO4 mobile electrolyte that can be converted into an insoluble species by electrolysis during the charge/discharge process. This will help

  12. New concepts of nuclear reactors and fuel cycles: performing agile technometric studies to understand the promises and the current reality

    International Nuclear Information System (INIS)

    The progress of previous projects pointed out the need to face some problems of software for detecting emerging research and development trends from databases of scientific publication. Given the lack of efficient computing applications dedicated to this purpose that we consider to be an artifact of great usefulness to better planning R and D programs in institutions, which are obliged to manage and develop, with limited resources and within the realm of complex and multidisciplinary technology fields as is the case of the Brazilian nuclear sector. We performed a review of the currently available software in such a way that we could clearly delineate the opportunity to develop new tools. As a result, we developed a software called Cite snake, which was especially designed to help the detection and study of emerging trends from the analysis of networks of various types extracted from the scientific databases. Using this powerful and stable computational tool, we performed preliminary analyzes of emerging research and development trends in a few thematic fields. The case that concerns this paper is the one devoted to the eld of Generation IV Nuclear Power Generation Systems. We analyzed the productivity of authors, co-authorship networks, co-citation networks, development structure and emerging sub-areas of research. The idea was to nd what reactors and fuel cycles have evolved more over the past ten years, in such a way to compare the what from the most promising concepts selected from the Generation Four Initiative have better evolved to fulfill some of their promises. (author)

  13. New concepts of nuclear reactors and fuel cycles: performing agile technometric studies to understand the promises and the current reality

    Energy Technology Data Exchange (ETDEWEB)

    Reis Junior, Jose S.B.; Barroso, Antonio C.O., E-mail: jsreis@ipen.br, E-mail: barroso@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    The progress of previous projects pointed out the need to face some problems of software for detecting emerging research and development trends from databases of scientific publication. Given the lack of efficient computing applications dedicated to this purpose that we consider to be an artifact of great usefulness to better planning R and D programs in institutions, which are obliged to manage and develop, with limited resources and within the realm of complex and multidisciplinary technology fields as is the case of the Brazilian nuclear sector. We performed a review of the currently available software in such a way that we could clearly delineate the opportunity to develop new tools. As a result, we developed a software called Cite snake, which was especially designed to help the detection and study of emerging trends from the analysis of networks of various types extracted from the scientific databases. Using this powerful and stable computational tool, we performed preliminary analyzes of emerging research and development trends in a few thematic fields. The case that concerns this paper is the one devoted to the eld of Generation IV Nuclear Power Generation Systems. We analyzed the productivity of authors, co-authorship networks, co-citation networks, development structure and emerging sub-areas of research. The idea was to nd what reactors and fuel cycles have evolved more over the past ten years, in such a way to compare the what from the most promising concepts selected from the Generation Four Initiative have better evolved to fulfill some of their promises. (author)

  14. Cerebellar Transcranial Direct Current Stimulation (ctDCS): A Novel Approach to Understanding Cerebellar Function in Health and Disease.

    Science.gov (United States)

    Grimaldi, Giuliana; Argyropoulos, Georgios P; Bastian, Amy; Cortes, Mar; Davis, Nicholas J; Edwards, Dylan J; Ferrucci, Roberta; Fregni, Felipe; Galea, Joseph M; Hamada, Masahi; Manto, Mario; Miall, R Chris; Morales-Quezada, Leon; Pope, Paul A; Priori, Alberto; Rothwell, John; Tomlinson, S Paul; Celnik, Pablo

    2016-02-01

    The cerebellum is critical for both motor and cognitive control. Dysfunction of the cerebellum is a component of multiple neurological disorders. In recent years, interventions have been developed that aim to excite or inhibit the activity and function of the human cerebellum. Transcranial direct current stimulation of the cerebellum (ctDCS) promises to be a powerful tool for the modulation of cerebellar excitability. This technique has gained popularity in recent years as it can be used to investigate human cerebellar function, is easily delivered, is well tolerated, and has not shown serious adverse effects. Importantly, the ability of ctDCS to modify behavior makes it an interesting approach with a potential therapeutic role for neurological patients. Through both electrical and non-electrical effects (vascular, metabolic) ctDCS is thought to modify the activity of the cerebellum and alter the output from cerebellar nuclei. Physiological studies have shown a polarity-specific effect on the modulation of cerebellar-motor cortex connectivity, likely via cerebellar-thalamocortical pathways. Modeling studies that have assessed commonly used electrode montages have shown that the ctDCS-generated electric field reaches the human cerebellum with little diffusion to neighboring structures. The posterior and inferior parts of the cerebellum (i.e., lobules VI-VIII) seem particularly susceptible to modulation by ctDCS. Numerous studies have shown to date that ctDCS can modulate motor learning, and affect cognitive and emotional processes. Importantly, this intervention has a good safety profile; similar to when applied over cerebral areas. Thus, investigations have begun exploring ctDCS as a viable intervention for patients with neurological conditions. PMID:25406224

  15. Currents and other physical parameters collected from moored current meters and various ADCPs offshore the United Kingdom, as part of British Oceanographic Data Center's (BODC) current meter series, from 21 June 1967 to 29 April 2007 (NODC Accession 0067029)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The BODC current meter data set provides all currents data held in the BODC National Oceanographic Database (NODB). It includes entries for Moored Acoustic Doppler...

  16. Current (1984) status of the study of 226Ra and 228Ra in humans at the Center for Human Radiobiology

    International Nuclear Information System (INIS)

    The Center for Human Radiobiology has identified 5784 persons by name and type of exposure to 226Ra and 228Ra. Included are 4863 dial painters (mostly women) and non-laboratory employees of the radium dial industry, 410 laboratory workers, 399 persons who received radium for supposed therapeutic effects, and 112 in other categories. Body contents of radium have been measured in 1916 of the dial workers and about one-half of the subjects in the other groups. Bone sarcomas, carcinomas of the paranasal sinuses and mastoids, and deterioration of skeletal tissue are still the only effects unequivocally attributable to internal radium. Excess leukemias have not been observed and other malignancies, if in excess, appear more likely to be related to external gamma radiation or radon than to internal radium. Positive correlations with radium burdens have been found for the incidence of benign exostoses among subjects exposed to radium before age 18 and for shortened latency of ocular cataracts. 27 references, 3 figures, 5 tables

  17. Current (1984) status of the study of 226Ra and 228Ra in humans at the Center for Human Radiobiology

    International Nuclear Information System (INIS)

    The Center for Human Radiobiology has identified 5784 persons by name and type of exposure to 226Ra and 228Ra. Included are 4863 dial painters (mostly women) and non-laboratory employees of the radium dial industry, 410 laboratory workers, 399 persons who received radium for supposed therapeutic effects, and 112 in other categories. Body contents of radium have been measured in 1916 of the dial workers and about one-half of the subjects in the other groups. Bone sarcomas, carcinomas of the paranasal sinuses and mastoids, and deterioration of skeletal tissue are still the only effects unequivocally attributable to internal radium. Excess leukemias have not been observed and other malignancies, if in excess, appear more likely to be related to external gamma radiation or radon than to internal radium. Positive correlations with radium burdens have been found for the incidence of benign exostoses among subjects exposed to radium before age 18 and for shortened latency of ocular cataracts. 26 references, 3 figures, 5 tables

  18. Understanding Alzheimer's

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Alzheimer's Past Issues / Fall 2007 Table of Contents For ... and brain scans. No treatment so far stops Alzheimer's. However, for some in the disease's early and ...

  19. Understanding Flu

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Flu Past Issues / Fall 2006 Table of Contents For ... McClain Whether the topic is seasonal influenza, bird flu or something called a pandemic, everyone seems to ...

  20. Current understanding of food allergy.

    Science.gov (United States)

    Burks, Wesley

    2002-05-01

    IgE-mediated hypersensitivity reactions account for the majority of well-documented food allergy reactions, but non-IgE-mediated immune mechanisms do cause some hypersensitivity disorders. A variety of gastrointestinal, cutaneous, respiratory, and generalized symptoms and syndromes have been associated with IgE-mediated food allergy. The diagnostic approach to adverse food reactions begins with a careful medical history and physical examination. Laboratory studies may then be used appropriately in the evaluation. Once the diagnosis of food allergy is established, the only proven therapy is the strict elimination of the food from the patient's diet. Studies in both children and adults indicate that symptomatic reactivity to food allergens is often lost over time, except possibly reactions to peanuts, tree nuts, and seafood. PMID:12023192

  1. Avian Influenza: Our current understanding

    Science.gov (United States)

    Avian influenza virus (AIV) has become one of the most important diseases of the poultry industry around the world. The virus has a broad host range in birds and mammals, although the natural reservoir is considered to be in wild birds where it typically causes an asymptomatic to mild infection. T...

  2. Potentials and limitations of the use of geo-history for the understanding of current features and conditions and possible future evolutions

    International Nuclear Information System (INIS)

    One of the main objectives of the Site Descriptive Models used by SKB (The Swedish Nuclear Fuel and Waste Management Company) in Sweden and POSIVA in Finland is to describe the chemistry and distribution of the groundwater in the bedrock and overburden and the processes involved in its origin and evolution. Through various cooperation projects the two companies have created models and understanding of the geo-history and the effects on the current groundwater features, conditions and possible future evolution but also an understanding of the limits of such modelling approaches. The SKB/POSIVA hydro-geochemistry programmes are intended to fulfill two basic requirements: 1) to provide representative and quality assured data for use as input parameter values in calculating long-term repository safety, and 2) to understand the past and present hydrogeochemical conditions, and how these conditions will change in the future. Parameter values for safety analysis include pH, Eh, S, SO4, HCO3, PO4 and TDS, together with colloids, fulvic and humic acids, other organics, bacteria and dissolved gases. The geo-historical evaluation and modelling requires an extensive geochemical data set including isotopic information. The groundwater values and their expected changes will be used to characterise the groundwater environment at, above and below repository depths. When the hydrogeochemical environment has been fully characterised, this knowledge, together with an understanding of the past and present groundwater evolution, will provide the basis for predicting future changes. The site investigations will therefore provide important source material for safety analyses and the environmental impact assessment of the studied areas. (authors)

  3. Energy efficient data centers

    Energy Technology Data Exchange (ETDEWEB)

    Tschudi, William; Xu, Tengfang; Sartor, Dale; Koomey, Jon; Nordman, Bruce; Sezgen, Osman

    2004-03-30

    Data Center facilities, prevalent in many industries and institutions are essential to California's economy. Energy intensive data centers are crucial to California's industries, and many other institutions (such as universities) in the state, and they play an important role in the constantly evolving communications industry. To better understand the impact of the energy requirements and energy efficiency improvement potential in these facilities, the California Energy Commission's PIER Industrial Program initiated this project with two primary focus areas: First, to characterize current data center electricity use; and secondly, to develop a research ''roadmap'' defining and prioritizing possible future public interest research and deployment efforts that would improve energy efficiency. Although there are many opinions concerning the energy intensity of data centers and the aggregate effect on California's electrical power systems, there is very little publicly available information. Through this project, actual energy consumption at its end use was measured in a number of data centers. This benchmark data was documented in case study reports, along with site-specific energy efficiency recommendations. Additionally, other data center energy benchmarks were obtained through synergistic projects, prior PG&E studies, and industry contacts. In total, energy benchmarks for sixteen data centers were obtained. For this project, a broad definition of ''data center'' was adopted which included internet hosting, corporate, institutional, governmental, educational and other miscellaneous data centers. Typically these facilities require specialized infrastructure to provide high quality power and cooling for IT equipment. All of these data center types were considered in the development of an estimate of the total power consumption in California. Finally, a research ''roadmap'' was developed

  4. Surficial Expressions of Deeper Processes- Ridge 2000 Spurs Understanding of Mantle-Hydrothermal Connections and the Role of Crustal Processes at Oceanic Spreading Centers

    Science.gov (United States)

    Blackman, D. K.

    2011-12-01

    A decade ago the Ridge 2000 (R2K) program began implementing the Integrated Studies Site (ISS) strategy as a means to advance understanding of the linked magmatic/tectonic/hydrothermal systems that dictate the structure and ecosystems observed in young crust along the spreading axis. Through comparison amongst ISSs and other well-studied sites, where controlling factors such as spreading rate or tectonic/thermal setting differ, a number of new insights have been gained. I will review progress on 3 aspects, emphasizing R2K contributions but also noting a few other recent results: the pattern of magma supply, along and across axis; ridge segmentation and crust/mantle interplay; threshold behavior and limiting processes that are manifested in crustal properties. The results are derived from petrological/geochemical, seismic (imaging, seismicity, compliance), electromagnetic, modeling, and mapping investigations, so I will touch on each of these types of constraint. The breadth of the melt supply zone is an example where R2K results document that influx to at least the lower crust can extend out several km beyond the axial graben. Such knowledge addresses a fundamental problem in Earth Sciences- how magmatism and faulting interact and the potential for hydrothermal circulation to both influence, and be influenced by, their distributions. In addition to briefly summarizing work already completed, I will highlight efforts on the mantle portions of the Juan de Fuca and Lau ISS that are currently underway, using data/modeling from the final phase of R2K, to tease out further connections between mantle processes and crustal structure, within which the now-known-to-be-ubiquitous hydrothermal systems develop.

  5. A Qualitative Study to Understand the Social and Emotional Needs of the Gifted Adolescents, Who Attend the Science and Arts Centers in Turkey

    Science.gov (United States)

    Yilmaz, Defne

    2015-01-01

    Considering all areas of development in education is a key to fulfill the needs of gifted students. This study which was based on qualitative methods aimed to find out the emotional and social needs of the adolescents who attended the Antalya Science and Arts Center (Bilim ve Sanat Egitim Merkezi-BILSEM) to develop new ways to help these students.…

  6. Center for Media Literacy Unveils the CML Medialit Kit[TM]: A Free Educational Framework that Helps Students Challenge and Understand Media

    Science.gov (United States)

    Social Studies, 2004

    2004-01-01

    Five key questions form the basis of the new CML MediaLit Kit, an educational framework and curriculum guide developed by the Center for Media Literacy. Adaptable to all grades, the key questions help children and young people evaluate the thousands of media messages that bombard them daily. More than two years in development and available for…

  7. Teaching Teaching & Understanding Understanding

    DEFF Research Database (Denmark)

    2006-01-01

    "Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what a...

  8. Trying to understand the different pieces of the construct validity puzzle of assessment centers: an examination of assessor and assessee effects.

    Science.gov (United States)

    Lievens, Filip

    2002-08-01

    This study examined the effects of assessor-related factors (i.e., type of assessor) and assessee-related factors (i.e., type of assessee profile) on the construct validity of assessment center ratings. In particular, 3 types of assessors (26 industrial/organizational [I/O] psychologists, 20 managers, and 27 students), rated assessee performances that varied according to cross-exercise consistency (i.e., relatively inconsistent vs. relatively consistent) and dimension differentiation (relatively undifferentiated vs. relatively differentiated). Construct validity evidence was established for only one assessee profile and only in the I/O psychologist and managerial samples. More generally, these results indicate that 3 factors (poor design, assessor unreliability, and especially cross-situational inconsistent assessee performances) may explain why construct validity evidence is often not established in operational assessment centers. PMID:12184572

  9. Radiation Environment at LEO in the frame of Space Monitoring Data Center at Moscow State University - recent, current and future missions

    Science.gov (United States)

    Myagkova, Irina; Kalegaev, Vladimir; Panasyuk, Mikhail; Svertilov, Sergey; Bogomolov, Vitaly; Bogomolov, Andrey; Barinova, Vera; Barinov, Oleg; Bobrovnikov, Sergey; Dolenko, Sergey; Mukhametdinova, Ludmila; Shiroky, Vladimir; Shugay, Julia

    2016-04-01

    Radiation Environment of Near-Earth space is one of the most important factors of space weather. Space Monitoring Data Center of Moscow State University provides operational control of radiation conditions at Low Earth's Orbits (LEO) of the near-Earth space using data of recent (Vernov, CORONAS series), current (Meteor-M, Electro-L series) and future (Lomonosov) space missions. Internet portal of Space Monitoring Data Center of Skobeltsyn Institute of Nuclear Physics of Lomonosov Moscow State University (SINP MSU) http://swx.sinp.msu.ru/ provides possibilities to control and analyze the space radiation conditions in the real time mode together with the geomagnetic and solar activity including hard X-ray and gamma- emission of solar flares. Operational data obtained from space missions at L1, GEO and LEO and from the Earth's magnetic stations are used to represent radiation and geomagnetic state of near-Earth environment. The models of space environment that use space measurements from different orbits were created. Interactive analysis and operational neural network forecast services are based on these models. These systems can automatically generate alerts on particle fluxes enhancements above the threshold values, both for SEP and relativistic electrons of outer Earth's radiation belt using data from GEO and LEO as input. As an example of LEO data we consider data from Vernov mission, which was launched into solar-synchronous orbit (altitude 640 - 83 0 km, inclination 98.4°, orbital period about 100 min) on July 8, 2014 and began to receive scientific information since July 20, 2014. Vernov mission have provided studies of the Earth's radiation belt relativistic electron precipitation and its possible connection with atmosphere transient luminous events, as well as the solar hard X-ray and gamma-emission measurements. Radiation and electromagnetic environment monitoring in the near-Earth Space, which is very important for space weather study, was also realised

  10. Association of Relapse with Renal Outcomes under the Current Therapy Regimen for IgA Nephropathy: A Multi-Center Study.

    Directory of Open Access Journals (Sweden)

    Yanhong Yuan

    Full Text Available Renal relapse is a very common manifestation of IgA nephropathy (IgAN. The clinical characteristics and long-term outcomes of this condition have not yet been carefully explored.Patients with biopsy-proven IgAN between January 2005 and December 2010 from three medical centers in China was a primary cohort of patients. From January 2010 to April 2012, data of an independent cohort of IgAN patients from Ren Ji Hospital, Shanghai, China was collected using the same inclusion and exclusion criteria. These patients formed the validation cohort of this study.Of the patients with biopsy-proven IgAN from three medical centers, 489 patients achieved remission within 6 months following the therapy. Additionally, 76 (15.5% of these patients experienced a relapse after achieving remission. During the median follow-up period of 66 months, 6 patients (1.4% in the non-relapse group experienced renal deterioration, compared with 22 patients (29.6% in the relapse group. Our study indicated that each 1-mmHg increase in the baseline diastolic blood pressure (DBP was associated with a 4.5% increase in the risk of renal relapse; additionally, the male patients had a 3.324-fold greater risk of relapse compared with the female patients according to the adjusted multivariate Cox analysis. The nomogram was based on 489 patients achieved remission. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index and calibration curve. The results were validated using bootstrap resampling on the validation cohort.This study demonstrated that renal relapse is a potential predictor of prognostic outcomes in patients under the current therapeutic regimens for IgAN. And male patients with higher diastolic blood pressure had a greater risk of experiencing relapse.

  11. Primary Radiation Damage in Materials. Review of Current Understanding and Proposed New Standard Displacement Damage Model to Incorporate in Cascade Defect Production Efficiency and Mixing Effects

    International Nuclear Information System (INIS)

    Under the auspices of the NEA Nuclear Science Committee (NSC), the Working Party on Multi-scale Modelling of Fuels and Structural Materials for Nuclear Systems (WPMM) was established in 2008 to assess the scientific and engineering aspects of fuels and structural materials, aiming at evaluating multi-scale models and simulations as validated predictive tools for the design of nuclear systems, fuel fabrication and performance. The WPMM's objective is to promote the exchange of information on models and simulations of nuclear materials, theoretical and computational methods, experimental validation, and related topics. It also provides member countries with up-to-date information, shared data, models and expertise. The WPMM Expert Group on Primary Radiation Damage (PRD) was established in 2009 to determine the limitations of the NRT-dpa standard, in the light of both atomistic simulations and known experimental discrepancies, to revisit the NRT-dpa standard and to examine the possibility of proposing a new improved standard of primary damage characteristics. This report reviews the current understanding of primary radiation damage from neutrons, ions and electrons (excluding photons, atomic clusters and more exotic particles), with emphasis on the range of validity of the 'displacement per atom' (dpa) concept in all major classes of materials with the exception of organics. The report also introduces an 'athermal recombination-corrected dpa' (arc-dpa) relation that uses a relatively simple functional to address the well-known issue that 'displacement per atom' (dpa) overestimates damage production in metals under energetic displacement cascade conditions, as well as a 'replacements-per-atom' (rpa) equation, also using a relatively simple functional, that accounts for the fact that dpa is understood to severely underestimate actual atom relocation (ion beam mixing) in metals. (authors)

  12. Review of the Current Status of Intra-Arterial Thrombolysis for Treating Acute Cerebral Infarction: a Retrospective Analysis of the Data from Multiple Centers in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Deok Hee [University of Ulsan College of Medicine, Seoul (Korea, Republic of); Na, Dong Gyu [Seoul National University College of Medicine, Seoul (Korea, Republic of); Ihn, Yon Kwon [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)] (and others)

    2007-04-15

    The purpose of the study was to review the current status of intraarterial (IA) thrombolysis in Korea by conducting a retrospective analysis of the data from multiple domestic centers. The radiologists at each participating institution were asked to fill out case report forms on all patients who had undergone IA recanalization due to acute anterior circulation ischemia. These forms included clinical, imaging and procedure-related information. A central reader analyzed the CT/MR and angiographic results. The rates of successful recanalization, hemorrhagic transformation and functional outcome were obtained. The univariate analyses were performed together with the multivariate analysis. We analyzed the data from 163 patients, and they had been treated at seven institutes. The initial imaging modalities were CT for 46 patients (28%), MR for 63 (39%), and both for 54 (33%). Various mechanical treatment methods were applied together in 50% of the patients. Radiologically significant hemorrhage was noted in 20/155 patients (13%). We found various factors that influenced the recanalization rate and the occurrence of significant hemorrhagic transformations. The favorable outcome rate, reported as modified Rankin Scale {<=}2, was 40%, and the mortality rate was 11%. The factors that predicted a poor functional outcome were old age (p = 0.01), initially severe neurological symptoms (p < 0.0001), MR findings of a wide distribution of lesions (p = 0.001), involvement of the basal ganglia (p = 0.01), performance of procedures after working hours (p 0.01), failure of recanalization (p 0.003), contrast extravasation after the procedure (p = 0.007) and significant hemorrhagic transformation (p = 0.002). The subsequent multivariate analysis failed to show any statistically significant variable. There was a trend toward increased dependency on MR imaging during the initial evaluation and increased usage of combined pharmacologic/mechanical thrombolysis. The imaging and clinical

  13. Understanding Readers' Differing Understandings

    Science.gov (United States)

    Kucer, Stephen B.

    2015-01-01

    This research examines the characteristics of reader understandings that vary from those stated in the text. Eighty-seven fourth graders orally read complex academic literary and scientific texts, followed by probed retellings. Retold ideas not directly supported by, or reflective of, the texts were identified. These differing understandings…

  14. Re-examination of employability as ‘social’ practice: a workshop debate re-shaping current understandings and facilitating enhanced practice across generic to specific perspectives.

    OpenAIRE

    Reid, James; Aslett-Bentley, Avril

    2014-01-01

    Whilst present understandings of employability in Higher Education [HE] have been critically reviewed (e.g. Tibby, 2012a & 2012b; Aslett-Bentley, 2013), the focus on employability policy (BIS, 2011; Hill, 2012; Wilson, 2012) remains predominantly based on neo-liberal marketisation principles. However Reid, (2014) has challenged this by advocating a shift in thinking to account for the social and powerful practices of employability. Such a re-shaping focuses on the co-construction of relations...

  15. Examining the Quality of 21st Century Community Learning Center After-School Programs: Current Practices and Their Relationship to Outcomes

    Science.gov (United States)

    Paluta, Lauren M.; Lower, Leeann; Anderson-Butcher, Dawn; Gibson, Allison; Iachini, Aidyn L.

    2016-01-01

    Although many youths participate in afterschool programs, the research is unclear about which aspects of afterschool program quality contribute most to positive outcomes. This article examines the relationship among quality and outcomes of 21st Century Community Learning Centers (CLCCs) afterschool programs, as perceived by 3,388 stakeholders from…

  16. Physical understanding of trends in current collapse with atomic layer deposited dielectrics in AlGaN/GaN MOS heterojunction FETs

    Science.gov (United States)

    Ramanan, Narayanan; Lee, Bongmook; Misra, Veena

    2016-03-01

    Many passivation dielectrics are pursued for suppressing current collapse due to trapping/detrapping of access-region surface traps in AlGaN/GaN based metal oxide semiconductor heterojuction field effect transistors (MOS-HFETs). The suppression of current collapse can potentially be achieved either by reducing the interaction of surface traps with the gate via surface leakage current reduction, or by eliminating surface traps that can interact with the gate. But, the latter is undesirable since a high density of surface donor traps is required to sustain a high 2D electron gas density at the AlGaN/GaN heterointerface and provide a low ON-resistance. This presents a practical trade-off wherein a passivation dielectric with the optimal surface trap characteristics and minimal surface leakage is to be chosen. In this work, we compare MOS-HFETs fabricated with popular ALD gate/passivation dielectrics like SiO2, Al2O3, HfO2 and HfAlO along with an additional thick plasma-enhanced chemical vapor deposition SiO2 passivation. It is found that after annealing in N2 at 700 °C, the stack containing ALD HfAlO provides a combination of low surface leakage and a high density of shallow donor traps. Physics-based TCAD simulations confirm that this combination of properties helps quick de-trapping and minimal current collapse along with a low ON resistance.

  17. Children are Centers for Understanding Media.

    Science.gov (United States)

    Rice, Susan, Ed.; Mukerji, Rose, Ed.

    Because of the importance of television in the lives of our children--they spend more time with it than in school--it makes sense that they should learn to process the vast input from television and become knowing and active about the media. This collection of essays presents ideas by contributors outside of the "painfully vague conclusions of the…

  18. A Feudal Way to Gentrify? The current understanding of gentrification and changes of social-topography in a medieval and early modern town

    OpenAIRE

    Thomasson, Joakim

    2004-01-01

    Gentrification is a current and often debated concept that concerns social changes in our cities. The concept relates to a development whereby areas earlier inhabited by less wealthy social groups are taken over by middle and upper middle-class residents. In the discussions of these changes, two perspectives have dominated. Representatives for the consumer perspective argue that gentrification occurs as a result of consumption preferences in the middle class. Representatives of the producer p...

  19. Evolution and current state of our understanding of the role played in the climate system by land surface processes in semi-arid regions

    Science.gov (United States)

    Nicholson, Sharon E.

    2015-10-01

    The role of the land surface in climate and weather has been a major research focus since the 1970s. Since that time our understanding of the issue has greatly changed and many new themes in several disciplines are being considered. This article summarizes the changes in our understanding that have taken place in research on this topic and reviews principally papers that have appeared in the last two decades. Several other papers provide comprehensive reviews of literature that appeared prior to that time. The major changes that have occurred include 1) more sophisticated and rigorous analysis of desertification, 2) increased emphasis on hydrological processes, including the role of groundwater, 3) use of multi-model ensembles and regional models, 4) the emergence of the domain of ecohydrology, with emphasis on detailed feedbacks between water availability and vegetation, 5) examination of the hypothesis that vegetation feedback can produce abrupt climate change, 6) emphasis on the impacts on convective or synoptic-scale systems, and 7) consideration of the impact of aerosols, including the Saharan Air Layer. With the exception of desertification, each of these topics is reviewed.

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Offices & Centers Advisory Boards & Groups Budget & Appropriations Current Year Budget Annual Plan & Budget Proposal Congressional Justification NCI ... using statistics that researchers have collected over many years about people with the same type of cancer. ...

  1. Understanding Capsule Endoscopy

    Science.gov (United States)

    ... Management Products Endoscopy Unit Recognition Program - EURP Partnership Discounts ASGE Endoscopy Marketplace Career Center Tools to Educate ... with most new diagnostic procedures, not all insurance companies are currently reimbursing for this procedure. You may ...

  2. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Current Congress Legislative History Committees of Interest Legislative Resources Recent Public Laws Contact Overview History of NCI Contributing to Cancer Research Senior Leadership Director Previous Directors NCI Organization Divisions, Offices & Centers Advisory Boards & Groups Budget & Appropriations ...

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Directors NCI Organization Divisions, Offices & Centers Advisory Boards & Groups Budget & Appropriations Current Year Budget Annual Plan & Budget ... free survival. Because statistics are based on large groups of people, they cannot be used to predict ...

  4. Understanding Lustre Internals

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Feiyi [ORNL; Oral, H Sarp [ORNL; Shipman, Galen M [ORNL; Drokin, Oleg [ORNL; Wang, Di [ORNL; Huang, He [ORNL

    2009-04-01

    Lustre was initiated and funded, almost a decade ago, by the U.S. Department of Energy (DoE) Office of Science and National Nuclear Security Administration laboratories to address the need for an open source, highly-scalable, high-performance parallel filesystem on by then present and future supercomputing platforms. Throughout the last decade, it was deployed over numerous medium-to-large-scale supercomputing platforms and clusters, and it performed and met the expectations of the Lustre user community. As it stands at the time of writing this document, according to the Top500 list, 15 of the top 30 supercomputers in the world use Lustre filesystem. This report aims to present a streamlined overview on how Lustre works internally at reasonable details including relevant data structures, APIs, protocols and algorithms involved for Lustre version 1.6 source code base. More importantly, it tries to explain how various components interconnect with each other and function as a system. Portions of this report are based on discussions with Oak Ridge National Laboratory Lustre Center of Excellence team members and portions of it are based on our own understanding of how the code works. We, as the authors team bare all responsibilities for all errors and omissions in this document. We can only hope it helps current and future Lustre users and Lustre code developers as much as it helped us understanding the Lustre source code and its internal workings.

  5. El neoconstitucionalismo y el nuevo constitucionalismo latinoamericano: ¿dos corrientes llamadas a entenderse? || Neoconstitutionalism And The "New" Latin American Constitutionalism: Two Current Calls To Understand?

    Directory of Open Access Journals (Sweden)

    Nuria Belloso Martin

    2015-12-01

    Full Text Available Resumen: Entre las corrientes del neoconstitucionalismo y del nuevo constitucionalismo latinoamericano hay aspectos que las diferencian pero también un sustrato común, lo que permite sostener la posibilidad de un diálogo fructífero entre ambas corrientes. Lo “nuevo” del nuevo constitucionalismo latinoamericano no es lo nuevo del movimiento constitucional de Latinoamérica. Se analizarán los presupuestos, las líneas de análisis y las posiciones doctrinales sobre el nuevo constitucionalismo latinoamericano, a la vez que se destacarán las peculiaridades que lo caracterizan. Se identificarán los rasgos principales que caracterizan a una y otra corriente, tales como la omnipresencia de la Constitución, el protagonismo de los principios y el renovado papel asignado al Poder Judicial.Abstract: Among neoconstitutionalism currents and the new Latin American constitutionalism are aspects that differentiate but also a common substrate, allowing the possibility to hold a fruitful dialogue between the two currents. The main features that characterize and over current, such as the omnipresence of the Constitution, the role of the principles and the new role assigned to the judiciary be identified. The 'new' Latin American constitutionalism is not new constitutional movement in Latin America. Budgets, the lines of analysis and doctrinal positions on the new Latin American constitutionalism is analyzed, as well as the peculiarities that characterize it will be highlighted. Finally, it asks whether there is anything really "new" in the new Latin American constitutionalism.

  6. Understanding the current discourse of rehabilitation: With reference to disability models and rehabilitation policies for evaluation research in the South African Setting

    Directory of Open Access Journals (Sweden)

    G. Mji

    2013-12-01

    Full Text Available Evaluation of rehabilitation programmes is essentialin order to monitor its effectiveness and relevance. There is howevera need to consider policies when conducting evaluation researchin rehabilitation. The aim of this paper is to present the theoreticaland legislative underpinnings of rehabilitation in South Africa.A narrative review of national and international disability legislationand empirical research in context of rehabilitation was conducted.The findings of this review reveals that as a fluid construct, thediscourse of rehabilitation has been underpinned by the changingtheoretical and socio-political understandings of disability. This inturn has influenced various international and national health anddisability policies and legislations that oversee the implementation ofrehabilitation practice. Despite this, there has been little evaluationof public health rehabilitation services in context of these policies and legislations in South Africa. The fluidity of rehabilitationneed to be considered when conducting evaluation research in rehabilitation.

  7. Mi Pueblo Food Center

    Directory of Open Access Journals (Sweden)

    Alexis A. Babb

    2016-04-01

    Full Text Available This case describes a current growth opportunity for Mi Pueblo Food Center, a Hispanic grocery chain with locations throughout the Bay Area, California. The CEO of Mi Pueblo is contemplating opening a new store location in East Palo Alto, CA, which has been without a local, full-service grocery store for over 20 years. Case objectives are for students to develop an understanding of how the grocery industry operates, the risks and opportunities associated with opening a new grocery store location, and the impact on social, environmental, and economic sustainability. The SWOT (Strengths, Weaknesses, Opportunities, Threats framework is used to analyze whether or not it is feasible for Mi Pueblo to open a new location in East Palo Alto. This case may be used with students in graduate and advanced undergraduate courses.

  8. Current Titles

    Energy Technology Data Exchange (ETDEWEB)

    Various

    2006-06-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Jane Cavlina, Administrator, at 510/486-6036.

  9. Understanding S-shaped current-voltage characteristics of organic solar cells: Direct measurement of potential distributions by scanning Kelvin probe

    International Nuclear Information System (INIS)

    We present a comparison of the potential distribution along the cross section of bilayer poly(3-hexylthiophene)/1-(3-methoxycarbonyl)propyl-1-phenyl[6,6]C61 (P3HT/PCBM) solar cells, which show normal and anomalous, S-shaped current-voltage (IV) characteristics. We expose the cross sections of the devices with a focussed ion beam and measure them with scanning Kelvin probe microscopy. We find that in the case of S-shaped IV-characteristics, there is a huge potential drop at the PCBM/Al top contact, which does not occur in solar cells with normal IV-characteristics. This behavior confirms the assumption that S-shaped curves are caused by hindered charge transport at interfaces

  10. Understanding S-shaped current-voltage characteristics of organic solar cells: Direct measurement of potential distributions by scanning Kelvin probe

    Energy Technology Data Exchange (ETDEWEB)

    Saive, Rebecca, E-mail: rebecca.saive@innovationlab.de; Kowalsky, Wolfgang [InnovationLab GmbH, 69115 Heidelberg (Germany); Institut für Hochfrequenztechnik, TU Braunschweig, 38106 Braunschweig (Germany); Kirchhoff-Institute for Physics, Heidelberg University, 69120 Heidelberg (Germany); Mueller, Christian [InnovationLab GmbH, 69115 Heidelberg (Germany); Kirchhoff-Institute for Physics, Heidelberg University, 69120 Heidelberg (Germany); Schinke, Janusz; Lovrincic, Robert [InnovationLab GmbH, 69115 Heidelberg (Germany); Institut für Hochfrequenztechnik, TU Braunschweig, 38106 Braunschweig (Germany)

    2013-12-09

    We present a comparison of the potential distribution along the cross section of bilayer poly(3-hexylthiophene)/1-(3-methoxycarbonyl)propyl-1-phenyl[6,6]C61 (P3HT/PCBM) solar cells, which show normal and anomalous, S-shaped current-voltage (IV) characteristics. We expose the cross sections of the devices with a focussed ion beam and measure them with scanning Kelvin probe microscopy. We find that in the case of S-shaped IV-characteristics, there is a huge potential drop at the PCBM/Al top contact, which does not occur in solar cells with normal IV-characteristics. This behavior confirms the assumption that S-shaped curves are caused by hindered charge transport at interfaces.

  11. Case study of quasi-steady reconnection in Saturn's magnetotail, and update on our current understanding of mass transport and loss in Saturn's nightside magnetosphere

    Science.gov (United States)

    Jackman, C. M.; Thomsen, M. F.; Mitchell, D. G.; Sergis, N.; Arridge, C. S.; Felici, M.; Badman, S. V.; Paranicas, C.; Jia, X.; Hospodarsky, G. B.; Andriopoulou, M.; Khurana, K. K.; Smith, A. W.; Dougherty, M. K.

    2015-10-01

    We present a case study of an event from August20th (day 232) of 2006, as viewed by magnetic field, plasma, energetic particle and plasma wave sensors (MAG/CAPS/MIMI/RPWS) when the Cassini spacecraft was sampling the region near 32 Rs and 22 hours LT in Saturn's magnetotail. Cassini observed a strong northward-to-southward turning of the magnetic field, which is interpreted as the signature of dipolarization of the field as seen by the spacecraft planetward of the reconnection x-line. This event was accompanied by very rapid (up to ~1500 km s-1) thermal plasma flow toward the planet. At energies above 28 keV, energetic hydrogen and oxygen ion flow bursts were observed to stream planetward from a reconnection site downtail of the spacecraft. Meanwhile a strong field-aligned beam of energetic hydrogen was also observed to stream tailward, likely from an ionospheric source. Saturn Kilometric Radiation emissions were stimulated shortly after the observation of the dipolarization. We discuss the field, plasma, energetic particle and radio observations in the context of the impact this reconnection event had on global magnetospheric dynamics.We also discuss this event in terms of other recent studies of reconnection in Saturn's tail and update on the emerging picture concerning our understanding of how mass is transported and lost within Saturn's magnetosphere.

  12. Oceans and Human Health Center

    Science.gov (United States)

    ... through a deeper understanding of the causes of ocean-related health threats About Find out more about our Center ... research taking place at the University of Miami Oceans & Human Health Center More Gallery Check out our photo and ...

  13. Understanding and Reflection of the Current Statistics Work%对当前统计工作的几点认识与思考

    Institute of Scientific and Technical Information of China (English)

    沈伯鸣

    2014-01-01

    本文论述了服务型统计的概念。尽管统计服务对象是多元化的,但“用数据说话,用数据服务”依然是统计工作的主题,从而通过论述当前对统计数据要求的新挑战和统计应对工作的重点,尝试提高数据质量、融合资源、增强匹配、充分应用数据资料、拓宽服务领域应对统计数据来自环境、需求、匹配、责任等方面新挑战。%This paper elaborated the concept of service-oriented statistics. Though the service object is pluralistic,"sticking to da-ta and service with data"is still the theme of the statistics work. It also discussed the new challenges for the current statistical data and the focuses of statistics work. We should face up to the new challenges from the environment, needs, matching and responsi-bilities, through improving the quality of data, integrating re-sources, enhancing matching, making full use of statistical mate-rials, and expanding the field of service.

  14. Centering research

    DEFF Research Database (Denmark)

    Katan, Lina Hauge; Baarts, Charlotte

    share as the common aim of both research and education. Despite some similarities, we find that how the two groups engage in and benefit from reading and writing diverges significantly. Thus we have even more reason to believe that centering practice-based teaching on these aspects of research is a good......’ exercises tend to dominate the common understandings of research-based learning. Here we address a specific area of inquiry overlooked by previous studies: whether and how reading, thinking and writing indeed share the same learning potentials as the practical foundation for research-based teaching....... In the humanities and social sciences, integrated acts of reading, writing and thinking account for an obvious and substantial overlap in student and researcher practices, creating a clear opportunity for research-based teaching. Moreover, our empirical data point to reading, thinking and writing as quintessential...

  15. Current titles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Gretchen Hermes at (510) 486-5006 or address below for a User`s Guide. Copies of available papers can be ordered from: Theda Crawford National Center for Electron Microscopy, Lawrence Berkeley Laboratory, One Cyclotron Rd., MS72, Berkeley, California, USA 94720.

  16. Functional Toxicogenomics: Mechanism-Centered Toxicology

    OpenAIRE

    Vulpe, Chris D.; Matthew North

    2010-01-01

    Traditional toxicity testing using animal models is slow, low capacity, expensive and assesses a limited number of endpoints. Such approaches are inadequate to deal with the increasingly large number of compounds found in the environment for which there are no toxicity data. Mechanism-centered high-throughput testing represents an alternative approach to meet this pressing need but is limited by our current understanding of toxicity pathways. Functional toxicogenomics, the global study of the...

  17. Should I stay or should I go? Understanding families’ decisions regarding initiating, continuing, and terminating health services for managing pediatric obesity: the protocol for a multi-center, qualitative study

    Directory of Open Access Journals (Sweden)

    Ball Geoff DC

    2012-12-01

    Full Text Available Abstract Background At least two million Canadian children meet established criteria for weight management. Due to the adverse health consequences of obesity, most pediatric weight management research has examined the efficacy and effectiveness of interventions to improve lifestyle behaviors, reduce co-morbidities, and enable weight management. However, little information is available on families’ decisions to initiate, continue, and terminate weight management care. This is an important knowledge gap since a substantial number of families fail to initiate care after being referred for weight management while many families who initiate care discontinue it after a brief period of time. This research aims to understand the interplay between individual, family, environmental, and systemic factors that influence families’ decisions regarding the management of pediatric obesity. Methods/Design Individual interviews will be conducted with children and youth with obesity (n = 100 and their parents (n = 100 for a total number of 200 interviews with 100 families. Families will be recruited from four Canadian multi-disciplinary pediatric weight management centers in Vancouver, Edmonton, Hamilton, and Montreal. Participants will be purposefully-sampled into the following groups: (i Non-Initiators (5 families/site: referred for weight management within the past 6 months and did not follow-up the referral; (ii Initiators (10 families/site: referred for weight management within the past 6 months and did follow-up the referral with at least one clinic appointment; and (iii Continuers (10 families/site: participated in a formal weight management intervention within the past 12 months and did continue with follow-up care for at least 6 months. Interviews will be digitally recorded and analyzed using an ecological framework, which will enable a multi-level evaluation of proximal and distal factors that underlie families’ decisions regarding

  18. National Center on Family Homelessness

    Science.gov (United States)

    ... You are here Home National Center on Family Homelessness Center A staggering 2.5 million children are ... raise awareness of the current state of child homelessness in the United States, documents the number of ...

  19. Understanding Dyslexia

    Science.gov (United States)

    ... Can I Help a Friend Who Cuts? Understanding Dyslexia KidsHealth > For Teens > Understanding Dyslexia Print A A ... realize is that Sarah has dyslexia. What Is Dyslexia? Dyslexia (pronounced: dis-LEK-see-uh) is a ...

  20. THE CURRENT UNDERSTANDING OF FASHION ESSENCE

    OpenAIRE

    Anastasya Aleksandrovna Zhilina; Svetlana Mikhaylovna Moor

    2015-01-01

    The article considers a fashion as a real and an acting social fact that affects many aspects of the life of the individual and society. The interest in the ability to reflect the specific modes of social transformations becomes the basis for constructing a theoretical system of knowledge about it. Fashion as a scientific fact characterizes social processes that find manifestation in the outward culture forms and fashion meanings indicating the fashion values, which are endowed with certain p...

  1. THE CURRENT UNDERSTANDING OF FASHION ESSENCE

    Directory of Open Access Journals (Sweden)

    Anastasya Aleksandrovna Zhilina

    2015-09-01

    Full Text Available The article considers a fashion as a real and an acting social fact that affects many aspects of the life of the individual and society. The interest in the ability to reflect the specific modes of social transformations becomes the basis for constructing a theoretical system of knowledge about it. Fashion as a scientific fact characterizes social processes that find manifestation in the outward culture forms and fashion meanings indicating the fashion values, which are endowed with certain properties of objects and events. Fashion, by definition, has a tendency to constant movement and innovation. So it always reflects the social and cultural content of a certain period, the essence of which is disclosed in its sociocultural context. Fashion phenomenon is associated with diverse social relationships, in this connection it is manifested in a multidisciplinary description of various scientific facts. The theory of fashion generation consists of separate concepts that complement each other or makes alternative viewpoints. The development of science requires a search for a new approach.

  2. Current understanding of multi-species biofilms

    OpenAIRE

    Yang, Liang; Liu, Yang; Wu,Hong; Høiby, Niels; Molin, Søren; Zhi-jun SONG

    2011-01-01

    Direct observation of a wide range of natural microorganisms has revealed the fact that the majority of microbes persist as surface-attached communities surrounded by matrix materials, called biofilms. Biofilms can be formed by a single bacterial strain. However, most natural biofilms are actually formed by multiple bacterial species. Conventional methods for bacterial cleaning, such as applications of antibiotics and/or disinfectants are often ineffective for biofilm populations due to their...

  3. Phase inversion emulsification: Current understanding and applications.

    Science.gov (United States)

    Perazzo, A; Preziosi, V; Guido, S

    2015-08-01

    This review is addressed to the phase inversion process, which is not only a common, low-energy route to make stable emulsions for a variety of industrial products spanning from food to pharmaceuticals, but can also be an undesired effect in some applications, such as crude oil transportation in pipelines. Two main ways to induce phase inversion are described in the literature, i.e., phase inversion composition (PIC or catastrophic) and phase inversion temperature (PIT or transitional). In the former, starting from one phase (oil or water) with surfactants, the other phase is more or less gradually added until it reverts to the continuous phase. In PIT, phase inversion is driven by a temperature change without varying system composition. Given its industrial relevance and scientific challenge, phase inversion has been the subject of a number of papers in the literature, including extensive reviews. Due to the variety of applications and the complexity of the problem, most of the publications have been focused either on the phase behavior or the interfacial properties or the mixing process of the two phases. Although all these aspects are quite important in studying phase inversion and much progress has been done on this topic, a comprehensive picture is still lacking. In particular, the general mechanisms governing the inversion phenomenon have not been completely elucidated and quantitative predictions of the phase inversion point are limited to specific systems and experimental conditions. Here, we review the different approaches on phase inversion and highlight some related applications, including future and emerging perspectives. PMID:25632889

  4. Current understanding concerning intestinal stem cells

    Science.gov (United States)

    Cui, Shuang; Chang, Peng-Yu

    2016-01-01

    In mammals, the intestinal epithelium is a tissue that contains two distinct pools of stem cells: active intestinal stem cells and reserve intestinal stem cells. The former are located in the crypt basement membrane and are responsible for maintaining epithelial homeostasis under intact conditions, whereas the latter exhibit the capacity to facilitate epithelial regeneration after injury. These two pools of cells can convert into each other, maintaining their quantitative balance. In terms of the active intestinal stem cells, their development into functional epithelium is precisely controlled by the following signaling pathways: Wnt/β-catenin, Ras/Raf/Mek/Erk/MAPK, Notch and BMP/Smad. However, mutations in some of the key regulator genes associated with these signaling pathways, such as APC, Kras and Smad4, are also highly associated with gut malformations. At this point, clarifying the biological characteristics of intestinal stem cells will increase the feasibility of preventing or treating some intestinal diseases, such as colorectal cancer. Moreover, as preclinical data demonstrate the therapeutic effects of colon stem cells on murine models of experimental colitis, the prospects of stem cell-based regenerative treatments for ulcerous lesions in the gastrointestinal tract will be improved all the same. PMID:27610020

  5. Mapping the current situation in life and life satisfaction in specific areas of life Center for psychosocial rehabilitation clients, company MANA, ops Olomouc

    Directory of Open Access Journals (Sweden)

    Soňa Lemrová

    2014-12-01

    Full Text Available The paper is concerned with mapping the quality of life of individuals diagnosed with schizophrenia. Surveying the quality of life of schizophrenics may be complicated due to the symptomatology - e.g. negative results during the higher levels of anxiety. Apart from health: age, gender, occupation, family, social contacts, finances, opportunities for rehabilitation and psychoeducational programmes are all among the important factors of the individual quality of life. Our research group comprised 16 clients (male n=12, female n=4 of the Psychosocial Rehabilitation Centre, MANA o.p.s. Olomouc. Average age of our respondents was 38.2. Except for 4 male respondents, all the rest were unemployed at the time of the survey, 3 respondents were living alone, others with parents or a partner. Average age of the male respondents at the time of their first hospitalization was 22, of the female respondents 18.5. The Czech version of the Quality of life questionnaire (Dotazník životní spokojenosti - DŽS was the basis of our primary method. In view of the sociodemographic data of our respondents, we have surveyed the level of the individual quality of life in the areas of health, financial situation, oneself and friends, acquaintances and relatives. A supplementary method was based on the SEIQoL (Schedule for the Evaluation of Individual Quality of Life, a questionnaire for monitoring the importance of happiness with individually chosen life themes (QL and an overall level of quality of life (VAS. The goal was to ascertain the level of happiness in the aforementioned areas of life DŽS and the correlation with age, importance and quality of life themes and their correlation with current overall quality of life. The lowest level of happiness (DŽS was measured in the overall level of the current quality of life (VAS in connection to gender (male=60.7%, female=43.8%, but in view of the low number of female respondents (n=4 we consider this result an

  6. Understanding Prenatal Tests

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Prenatal Tests Past Issues / Winter 2008 Table of Contents ... be done before pregnancy or at the first prenatal visit. If there is Rh incompatibility, treatments can ...

  7. A reassessment of the potential for an alpha-mode containment failure and a review of the current understanding of broader fuel-coolant interaction issues. Second steam explosion review group workshop

    International Nuclear Information System (INIS)

    This report summarizes the review and evaluation by experts of the current understanding of the molten fuel-coolant interaction (FCI) issues covering the complete spectrum of interactions, i.e., from mild quenching to very energetic interactions including those that could lead to the alpha-mode containment failure. Of the eleven experts polled, all but two concluded that the alpha-mode failure issue was resolved from a risk perspective, meaning that this mode of failure is of very low probability, that it is of little or no significance to the overall risk from a nuclear power plant, and that any further reduction in residual uncertainties is not likely to change the probability in an appreciable manner. To a lesser degree, discussions also took place on the broader FCI issues such as mild quenching of core melt during non-explosive FCI, and shock loading of lower head and ex-vessel support structures arising from explosive localized FCIs. These latter issues are relevant with regard to determining the efficacy of certain accident management strategies for operating reactors as well as for advanced light water reactors. The experts reviewed the status of understanding of the FCI phenomena in the context of these broader issues, identified residual uncertainties in the understanding, and recommended future research (both experimental and analytical) to reduce the uncertainties

  8. A reassessment of the potential for an alpha-mode containment failure and a review of the current understanding of broader fuel-coolant interaction issues. Second steam explosion review group workshop

    Energy Technology Data Exchange (ETDEWEB)

    Basu, S. [Nuclear Regulatory Commission, Washington, DC (United States); Ginsberg, T. [Brookhaven National Lab., Upton, NY (United States)

    1996-08-01

    This report summarizes the review and evaluation by experts of the current understanding of the molten fuel-coolant interaction (FCI) issues covering the complete spectrum of interactions, i.e., from mild quenching to very energetic interactions including those that could lead to the alpha-mode containment failure. Of the eleven experts polled, all but two concluded that the alpha-mode failure issue was resolved from a risk perspective, meaning that this mode of failure is of very low probability, that it is of little or no significance to the overall risk from a nuclear power plant, and that any further reduction in residual uncertainties is not likely to change the probability in an appreciable manner. To a lesser degree, discussions also took place on the broader FCI issues such as mild quenching of core melt during non-explosive FCI, and shock loading of lower head and ex-vessel support structures arising from explosive localized FCIs. These latter issues are relevant with regard to determining the efficacy of certain accident management strategies for operating reactors as well as for advanced light water reactors. The experts reviewed the status of understanding of the FCI phenomena in the context of these broader issues, identified residual uncertainties in the understanding, and recommended future research (both experimental and analytical) to reduce the uncertainties.

  9. Senior Centers

    Medline Plus

    Full Text Available ... to do as long as they can. Senior centers, adult day care, transportation, and meals programs are ... older adults to remain in their homes. Senior centers are places where older adults who live independently ...

  10. Economics of data center optics

    Science.gov (United States)

    Huff, Lisa

    2016-03-01

    Traffic to and from data centers is now reaching Zettabytes/year. Even the smallest of businesses now rely on data centers for revenue generation. And, the largest data centers today are orders of magnitude larger than the supercomputing centers of a few years ago. Until quite recently, for most data center managers, optical data centers were nice to dream about, but not really essential. Today, the all-optical data center - perhaps even an all-single mode fiber (SMF) data center is something that even managers of medium-sized data centers should be considering. Economical transceivers are the key to increased adoption of data center optics. An analysis of current and near future data center optics economics will be discussed in this paper.

  11. Excel Center

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Citigroup,one of the World top 500 companies,has now settled in Excel Center,Financial Street. The opening ceremony of Excel Center and the entry ceremony of Citigroup in the center were held on March 31.Government leaders of Xicheng District,the Excel CEO and the heads of Asia-Pacific Region leaders of Citibank all participated in the ceremony.

  12. Data center networks topologies, architectures and fault-tolerance characteristics

    CERN Document Server

    Liu, Yang; Veeraraghavan, Malathi; Lin, Dong; Hamdi, Mounir

    2013-01-01

    This SpringerBrief presents a survey of data center network designs and topologies and compares several properties in order to highlight their advantages and disadvantages. The brief also explores several routing protocols designed for these topologies and compares the basic algorithms to establish connections, the techniques used to gain better performance, and the mechanisms for fault-tolerance. Readers will be equipped to understand how current research on data center networks enables the design of future architectures that can improve performance and dependability of data centers. This con

  13. Job center

    Science.gov (United States)

    To better meet the needs of AGU members, a program has been started to increase the effectiveness of the Job Center activity at the Spring and Fall Meetings. As a result, participation in the Job Center at the 1988 AGU Spring Meeting in Baltimore increased substantially compared to previous Spring Meetings. The number of employers, applicants, and interviews scheduled more than doubled compared to the 1987 Spring Job Center.In order to make the meeting Job Centers even better, a survey is being conducted of employers and applicants who participated in the 1988 Spring Job Center. Evaluation of this survey will be useful in continuing increased participation in and the effectiveness of the Job Center at the 1988 Fall Meeting. Past participants and those interested in the future of the Job Center are encouraged to forward comments and suggestions to AGU, Member Programs Division, 2000 Florida Ave., N.W., Washington, DC 20009.

  14. Know the Facts: Understand Concussion

    Centers for Disease Control (CDC) Podcasts

    2010-03-17

    This podcast discusses concussions and provides information to help people better understand concussion.  Created: 3/17/2010 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 3/17/2010.

  15. Vortex creep and critical current densities J c in a 2 μm thick SmBa2Cu3O7‑d coated conductor with mixed pinning centers grown by co-evaporation

    Science.gov (United States)

    Haberkorn, N.; Coulter, Y.; Condó, A. M.; Granell, P.; Golmar, F.; Ha, H. S.; Moon, S. H.

    2016-07-01

    We report the critical current densities J c and flux creep rates in a 2 μm thick SmBa2Cu3O7–δ coated conductor produced by co-evaporation. The sample presents strong pinning produced by correlated disorder (CD) (boundaries between growth islands, dislocations and twin boundaries) as well as random nanoparticles. Correlated pinning along the c-axis was evidenced due to the appearance of a large peak in the angular critical current, centered at H║c. The analysis of the critical current density J c (with the magnetic field applied parallel (H║c) and at 45° of the c-axis (H║45°)) indicates that CD assists pinning throughout the temperature range. For all temperatures and at both angles the in-field dependence of J c exhibits a power-law behavior. The contribution of CD drops when the field is rotated to intermediate angles between the c axis and a–b axis (i. e. H║45°), which derives in a reduction of the absolute J c value and poorer in-field dependences. The flux creep rate depends on the angle and its values remain approximately constant within the power-law regime. For H║c and H║45° and for magnetic fields lower than 20 kOe, the flux relaxation presents characterizing glassy exponents μ = 1.70 and μ = 1.32, respectively.

  16. Study on current situation of nursing human resources in community health service centers of Kunming City%昆明市社区卫生服务中心护理人力资源现状调查

    Institute of Scientific and Technical Information of China (English)

    卢蓉; 姜润生; 黄丽; 徐正英; 沈海文; 张杪

    2013-01-01

    目的 调查昆明市社区卫生服务中心护理人力资源现状.方法 采用自设问卷对昆明市11所社区卫生服务中心的109名社区护士进行调查.结果 社区护理队伍结构不合理,社区护士绩效考核体系不健全,缺乏科学有效的激励措施.结论应重视社区护理,调整队伍结构,建立健全管理体质,加快人才培养步伐.%Objective To investigate the current situation of nursing human resources of community health service centers of Kunming city.Methods A self-designed questionnaire was performed among 109 nurses of 11 community health services centers in Kunming.Results Structure of community nursing team was found unreasonable and the management system of human resources was not well organized.The scientific and effective intentive measures was lack.Conclusion It is suggested to pay more attention to the community nursing services in order to adjust the structure of community nursing team,pefect the management system and speed up the pace of personnel training.

  17. PACS strategy for imaging centers.

    Science.gov (United States)

    Bedel, Victoria; Zdanowicz, Mark

    2004-01-01

    Picture archiving and communications systems (PACS) have been available in imaging centers for many years, but they often were less functional, were not well integrated into patient information systems, and lacked the network backbone to implement a system. As modalities are replaced and technology improves, the ability and time for an imaging center to acquire, integrate, and utilize PACS has arrived. However, each imaging center must determine why it should invest in PACS. A business plan is the fundamental need. Each imaging center must understand its target market, growth rate, and staffing plans. Additional considerations lie in current and future modality availability, the need for offsite delivery of images and reports, and the potential need for remote transmission of images. These issues must be identified and prioritized. A multidisciplinary team is essential. The most successful PACS implementation begins with complete involvement from all levels. The team should be comprised of people with complementary skills who are committed to a common purpose, set of performance goals, and approach for which they hold themselves mutually accountable. The team must jointly decide on the project's objectives. These objectives fall under 4 categories: clinical, service, financial, and performance. PACS must be considered a tool to help accomplish each objective. The imaging center must determine its top priorities, then translate them into a technology "wish list." The center can then list those pieces of technology that are most important and prioritize them. There are even more considerations for connecting multiple imaging centers. The team must create a comprehensive request for proposal (RFP) and determine the vendors that will receive the document. Once the RFP responses have been received and the vendor has been selected, an effective training plan must be executed. Training plans should be competency-based, ensuring comfort and competency among all staff. Upon

  18. Understanding Chemotherapy

    Science.gov (United States)

    N ational C ancer I nstitute Understanding Chemotherapy What is chemotherapy? Chemotherapy is a cancer treatment that uses drugs to destroy cancer cells. It is also called “chemo.” Today, there are ...

  19. Understanding semantics

    DEFF Research Database (Denmark)

    Thrane, Torben

    1997-01-01

    Understanding natural language is a cognitive, information-driven process. Discussing some of the consequences of this fact, the paper offers a novel look at the semantic effect of lexical nouns and the identification of reference types.......Understanding natural language is a cognitive, information-driven process. Discussing some of the consequences of this fact, the paper offers a novel look at the semantic effect of lexical nouns and the identification of reference types....

  20. Functional Centering

    CERN Document Server

    Hahn, M

    1996-01-01

    Based on empirical evidence from a free word order language (German) we propose a fundamental revision of the principles guiding the ordering of discourse entities in the forward-looking centers within the centering model. We claim that grammatical role criteria should be replaced by indicators of the functional information structure of the utterances, i.e., the distinction between context-bound and unbound discourse elements. This claim is backed up by an empirical evaluation of functional centering.

  1. Distribution center

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Distribution center is a logistics link fulfill physical distribution as its main functionGenerally speaking, it's a large and hiahly automated center destined to receive goods from various plants and suppliers,take orders,fill them efficiently,and deliver goods to customers as quickly as possible.

  2. vCenter troubleshooting

    CERN Document Server

    Mills, Chuck

    2015-01-01

    The book is designed for the competent vCenter administrator or anyone who is responsible for the vSphere environment. It can be used as a guide by vSphere architects and VMware consultants for a successful vSphere solution. You should have good knowledge and an understanding of core elements and applications of the vSphere environment.

  3. Understanding physics

    CERN Document Server

    Mansfield, Michael

    2011-01-01

    Understanding Physics - Second edition is a comprehensive, yet compact, introductory physics textbook aimed at physics undergraduates and also at engineers and other scientists taking a general physics course. Written with today's students in mind, this text covers the core material required by an introductory course in a clear and refreshing way. A second colour is used throughout to enhance learning and understanding. Each topic is introduced from first principles so that the text is suitable for students without a prior background in physics. At the same time the book is designed to enable

  4. Understanding Leukemia

    Science.gov (United States)

    ... a second cancer, including melanoma, sarcoma, colorectal cancer, lung cancer, basal cell cancer, squamous cell skin cancer or myeloma. {{ See your primary care doctor to keep up with other healthcare needs. Understanding Leukemia I page 21 {{ Talk with family and friends about how ...

  5. Understanding Death.

    Science.gov (United States)

    Heath, Charles P.

    1986-01-01

    Bibliotherapy can help children prepare for and understand the death of a loved one. An annotated bibliography lists references with age level information on attitudes toward death and deaths of a father, friend, grandparent, mother, pet, and sibling. (Author/CL)

  6. Understanding Depression

    OpenAIRE

    McNair, F. E.

    1981-01-01

    To understand the effects of depression on a patient's life, the physician must be aware how depression manifests itself. Somatic tension, strategies to relieve discomfort and social withdrawal must be recognized as symptoms of depression. An awareness of life situations which can give rise to these symptoms, as well as the effect of the physician's own reactions to the patient's depression, are helpful.

  7. User-centered design

    International Nuclear Information System (INIS)

    The simplification philosophy, as an example, that both of EPRI-URD and EUR emphasize is treated mostly for the cost reduction of the nuclear power plants, but not for the simplification of the structure of user's tasks, which is one of the principles of user-centered design. A user-centered design is a philosophy based on the needs and interests of the user, with an emphasis on making products usable and understandable. However, the nuclear power plants offered these days by which the predominant reactor vendors are hardly user-centered but still designer-centered or technology-centered in viewpoint of fulfilling user requirements. The main goal of user-centered design is that user requirements are elicited correctly, reflected properly into the system requirements, and verified thoroughly by the tests. Starting from the user requirements throughout to the final test, each requirement should be traceable. That's why requirement traceability is a key to the user-centered design, and main theme of a requirement management program, which is suggested to be added into EPRI-URD and EUR in the section of Design Process. (author)

  8. 08251 Abstracts Collection -- Contextual and Social Media Understanding and Usage

    OpenAIRE

    Boll, Susanne; Mohan S. Kankanhalli; Pingali, Gopal; Venkatesh, Svetha

    2009-01-01

    From 15.06. to 20.06.2008, the Dagstuhl Seminar 08251 ``Contextual and Social Media Understanding and Usage '' was held in Schloss Dagstuhl~--~Leibniz Center for Informatics. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar top...

  9. Understanding Translation

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram; Gottlieb, Henrik; Klitgård, Ida

    phenomenon of translation and to provide you with a conceptual framework for the analysis of various aspects of professional translation. Intended readers are students of translation and languages, but the book will also be relevant for others who are interested in the theory and practice of translation......Understanding Translation is designed as a textbook for courses on the theory and practice of translation in general and of particular types of translation - such as interpreting, screen translation and literary translation. The aim of the book is to help you gain an in-depth understanding of the...... - translators, language teachers, translation users and literary, TV and film critics, for instance. Discussions focus on translation between Danish and English....

  10. Understanding Resilience

    Directory of Open Access Journals (Sweden)

    Gang eWu

    2013-02-01

    Full Text Available Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life events, trauma and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of PTSD, depression and other psychiatric disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, and are thus thought to be resilient. Resilience as successful adaptation relies on effective responses to environmental challenges and ultimate resistance to the deleterious effects of stress, therefore a greater understanding of the factors that promote such effects is of great relevance. This review focuses on recent findings regarding genetic, epigenetic, developmental, psychosocial and neurochemical factors that are considered essential contributors to the development of resilience. Neural circuits and pathways involved in mediating resilience are also discussed. The growing understanding of resilience factors will hopefully lead to the development of new pharmacological and psychological interventions for enhancing resilience and mitigating the untoward consequences.

  11. Understanding users

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav Viggo

    2014-01-01

    Segmentation of users can help libraries in the process of understanding user similarities and differences. Segmentation can also form the basis for selecting segments of target users and for developing tailored services for specific target segments. Several approaches and techniques have been te...... segmentation project using computer-generated clusters. Compared to traditional marketing texts, this article also tries to identify user segments or images or metaphors by the library profession itself.......Segmentation of users can help libraries in the process of understanding user similarities and differences. Segmentation can also form the basis for selecting segments of target users and for developing tailored services for specific target segments. Several approaches and techniques have been...... tested in library contexts and the aim of this article is to identify the main approaches and to discuss their perspectives, including their strenghts and weaknesses in, especially, public library contexts. The purpose is also to prsent and discuss the results of a recent - 2014 - Danish library user...

  12. Understanding Flight

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, David

    2001-01-31

    Through the years the explanation of flight has become mired in misconceptions that have become dogma. Wolfgang Langewiesche, the author of 'Stick and Rudder' (1944) got it right when he wrote: 'Forget Bernoulli's Theorem'. A wing develops lift by diverting (from above) a lot of air. This is the same way that a propeller produces thrust and a helicopter produces lift. Newton's three laws and a phenomenon called the Coanda effect explain most of it. With an understanding of the real physics of flight, many things become clear. Inverted flight, symmetric wings, and the flight of insects are obvious. It is easy to understand the power curve, high-speed stalls, and the effect of load and altitude on the power requirements for lift. The contribution of wing aspect ratio on the efficiency of a wing, and the true explanation of ground effect will also be discussed.

  13. Understand electronics

    CERN Document Server

    Bishop, Owen

    2013-01-01

    Understand Electronics provides a readable introduction to the exciting world of electronics for the student or enthusiast with little previous knowledge. The subject is treated with the minimum of mathematics and the book is extensively illustrated.This is an essential guide for the newcomer to electronics, and replaces the author's best-selling Beginner's Guide to Electronics.The step-by-step approach makes this book ideal for introductory courses such as the Intermediate GNVQ.

  14. Senior Centers

    Medline Plus

    Full Text Available ... variety of social and recreational activities. [Karen Albers] We provide a wide variety of activities -- physical, health, ... senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, tap dancing, ballroom dancing, ...

  15. Senior Centers

    Medline Plus

    Full Text Available ... transportation, and meals programs are long-term care services available in the community which make it easier ... about senior centers and other long-term care services available in your community, contact the Eldercare Locator ...

  16. Senior Centers

    Medline Plus

    Full Text Available ... Karen Albers] We provide a wide variety of activities -- physical, health, mental health programs with Senior Plus, cognitive ... of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ...

  17. Senior Centers

    Medline Plus

    Full Text Available [Narrator] Living independently at home is something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, and meals programs are ...

  18. Senior Centers

    Medline Plus

    Full Text Available ... Living independently at home is something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, and meals programs are long- ...

  19. Senior Centers

    Medline Plus

    Full Text Available ... of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ... chi, tap dancing, ballroom dancing, square dancing, chair exercise, arthritis classes, yoga, and lots of dancing. [Narrator] ...

  20. Senior Centers

    Medline Plus

    Full Text Available ... something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, ... adults who live independently can go to find a variety of social and recreational activities. [Karen Albers] ...

  1. Understanding biplots

    CERN Document Server

    Gower, John C; Le Roux, Niel J

    2010-01-01

    Biplots are a graphical method for simultaneously displaying two kinds of information; typically, the variables and sample units described by a multivariate data matrix or the items labelling the rows and columns of a two-way table. This book aims to popularize what is now seen to be a useful and reliable method for the visualization of multidimensional data associated with, for example, principal component analysis, canonical variate analysis, multidimensional scaling, multiplicative interaction and various types of correspondence analysis. Understanding Biplots: Introduces th

  2. Understanding uncertainty

    CERN Document Server

    Lindley, Dennis V

    2013-01-01

    Praise for the First Edition ""...a reference for everyone who is interested in knowing and handling uncertainty.""-Journal of Applied Statistics The critically acclaimed First Edition of Understanding Uncertainty provided a study of uncertainty addressed to scholars in all fields, showing that uncertainty could be measured by probability, and that probability obeyed three basic rules that enabled uncertainty to be handled sensibly in everyday life. These ideas were extended to embrace the scientific method and to show how decisions, containing an uncertain element, could be rationally made.

  3. User Centered Design

    DEFF Research Database (Denmark)

    Egbert, Maria; Matthews, Ben

    The interdisciplinary approach of User Centered Design is presented here with a focus on innovation in the design and use of hearing technologies as well as on the potential of innovation in interaction. This approach is geared towards developing new products, systems, technologies and practices...... based on an understanding of why so few persons with hearing loss use the highly advanced hearing technologies. In integrating Conversation Analysis (“CA”), audiology and User Centered Design, three disciplines which are collaborating together for the first time, we are addressing the following...

  4. Understanding analysis

    CERN Document Server

    Abbott, Stephen

    2015-01-01

    This lively introductory text exposes the student to the rewards of a rigorous study of functions of a real variable. In each chapter, informal discussions of questions that give analysis its inherent fascination are followed by precise, but not overly formal, developments of the techniques needed to make sense of them. By focusing on the unifying themes of approximation and the resolution of paradoxes that arise in the transition from the finite to the infinite, the text turns what could be a daunting cascade of definitions and theorems into a coherent and engaging progression of ideas. Acutely aware of the need for rigor, the student is much better prepared to understand what constitutes a proper mathematical proof and how to write one. Fifteen years of classroom experience with the first edition of Understanding Analysis have solidified and refined the central narrative of the second edition. Roughly 150 new exercises join a selection of the best exercises from the first edition, and three more project-sty...

  5. Understanding resilience.

    Science.gov (United States)

    Wu, Gang; Feder, Adriana; Cohen, Hagit; Kim, Joanna J; Calderon, Solara; Charney, Dennis S; Mathé, Aleksander A

    2013-01-01

    Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life events, trauma, and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of posttraumatic stress disorder (PTSD), depression and other psychiatric disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, and are thus thought to be resilient. Resilience as successful adaptation relies on effective responses to environmental challenges and ultimate resistance to the deleterious effects of stress, therefore a greater understanding of the factors that promote such effects is of great relevance. This review focuses on recent findings regarding genetic, epigenetic, developmental, psychosocial, and neurochemical factors that are considered essential contributors to the development of resilience. Neural circuits and pathways involved in mediating resilience are also discussed. The growing understanding of resilience factors will hopefully lead to the development of new pharmacological and psychological interventions for enhancing resilience and mitigating the untoward consequences. PMID:23422934

  6. Understanding physics

    CERN Document Server

    Cassidy, David; Rutherford, James

    2002-01-01

    Understanding Physics provides a thorough grounding in contemporary physics while placing physics into its social and historical context Based in large part on the highly respected Project Physics Course developed by two of the authors, it also integrates the results of recent pedagogical research The text thus - teaches about the basic phenomena in the physical world and the concepts developed to explain them - shows that science is a rational human endeavor with a long and continuing tradition, involving many different cultures and people - develops facility in critical thinking, reasoned argumentation, evaluation of evidence, mathematical modeling, and ethical values The treatment emphasizes not only what we know but also how we know it, why we believe it, and what effects that knowledge has - Why do we believe the Earth and planets revolve around the Sun? - Why do we believe that matter is made of atoms? - How do relativity theory and quantum mechanics alter our conception of Nature and in what ways do th...

  7. Understanding Capitalism

    DEFF Research Database (Denmark)

    du Gay, Paul; Morgan, Glenn

    2013-01-01

    they are to be sustained. Such logics are stabilized to the degree that they can pass the tests which they set themselves. The chapter shows how the projective city has increasingly failed these tests. It has instead created a privileged group of ‘mobile citizens’ working with mobile, global capital in...... ways that increasingly depend on a static, immobile group who are poorly paid, whose employment rights have been undermined and whose political voice is increasingly ignored. The chapter shows how Boltanski's pragmatist approach to critique as emergent from the experience of the actors themselves...... rather than being imposed by the analyst provides the basis for an understanding of how social and artistic critiques emerge. Whilst recognizing that New Spirits inevitably bears the marks of its origins in the particular context of France in the late 1990s, the chapter argues that there are key aspects...

  8. Functional Toxicogenomics: Mechanism-Centered Toxicology

    Directory of Open Access Journals (Sweden)

    Chris D. Vulpe

    2010-11-01

    Full Text Available Traditional toxicity testing using animal models is slow, low capacity, expensive and assesses a limited number of endpoints. Such approaches are inadequate to deal with the increasingly large number of compounds found in the environment for which there are no toxicity data. Mechanism-centered high-throughput testing represents an alternative approach to meet this pressing need but is limited by our current understanding of toxicity pathways. Functional toxicogenomics, the global study of the biological function of genes on the modulation of the toxic effect of a compound, can play an important role in identifying the essential cellular components and pathways involved in toxicity response. The combination of the identification of fundamental toxicity pathways and mechanism-centered targeted assays represents an integrated approach to advance molecular toxicology to meet the challenges of toxicity testing in the 21st century.

  9. Senior Centers

    Medline Plus

    Full Text Available ... provide a wide variety of activities -- physical, health, mental health programs with Senior Plus, cognitive programs, a wide variety of general activities, billiards, Bingo, lots of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ...

  10. Hastings Center

    Science.gov (United States)

    ... BLOG We have long had the ability, we humans, to work outside the bounds of evolution. Dairy cattle, maize, and all sorts of dog ... intervention. However, in the past, the scope of human intervention was rather… Read more Share: ... Evolution? Read more HASTINGS NEWS Hastings Center research scholar ...

  11. Senior Centers

    Medline Plus

    Full Text Available ... dancing. [Narrator] These centers can provide entree to new activities and expand a person’s social contacts. [Karen ... meeting all their interests and introducing them to new things; whether it’s an arts and crafts project, ...

  12. Senior Centers

    Medline Plus

    Full Text Available ... transportation, and meals programs are long-term care services available in the community which make it easier for older adults to ... about senior centers and other long-term care services available in your community, contact the Eldercare Locator at 1-800-677- ...

  13. Starting a sleep center.

    Science.gov (United States)

    Epstein, Lawrence J; Valentine, Paul S

    2010-05-01

    The demand for sleep medicine services has grown tremendously during the last decade and will likely continue. To date, growth in demand has been met by growth in the number of new sleep centers. The need for more new centers will be dependent on market drivers that include increasing regulatory requirements, personnel shortages, integration of home sleep testing, changes in reimbursement, a shift in emphasis from diagnostics to treatment, and an increased consumer focus on sleep. The decision to open a new center should be based on understanding the market dynamics, completing a market analysis, and developing a business plan. The business plan should include an overview of the facility, a personnel and organizational structure, an evaluation of the business environment, a financial plan, a description of services provided, and a strategy for obtaining, managing, and extending a referral base. Implementation of the business plan and successful operation require ongoing planning and monitoring of operational parameters. The need for new sleep centers will likely continue, but the shifting market dynamics indicate a greater need for understanding the marketplace and careful planning. PMID:20442123

  14. Current interruption transients calculation

    CERN Document Server

    Peelo, David F

    2014-01-01

    Provides an original, detailed and practical description of current interruption transients, origins, and the circuits involved, and how they can be calculated Current Interruption Transients Calculationis a comprehensive resource for the understanding, calculation and analysis of the transient recovery voltages (TRVs) and related re-ignition or re-striking transients associated with fault current interruption and the switching of inductive and capacitive load currents in circuits. This book provides an original, detailed and practical description of current interruption transients, origins,

  15. Understanding PISA

    Directory of Open Access Journals (Sweden)

    Stephen DOWNES

    2005-04-01

    Full Text Available Understanding PISA Stephen DOWNESMoncton, CANADA ABSTRACT The headline was dramatic enough to cause a ripple in the reading public. "Students who use computers a lot at school have worse maths and reading performance," noted the BBC news article, citing a 2004 study by Ludger Woessmann and Thomas Fuchs (Fuchs and Woessman, 2004. It was not long before the blogosphere took notice. Taking the theme and running with it, Alice and Bill ask, "Computers Make School Kids Dumber?" They theorize, "If you track the admitted decline of education, you'll probably notice that it follows along with the increase of technology in the classroom." In a similar vein, James Bartholomew asks, "Do you think that the government will turn down the volume of its boasting about how it has spent billions introducing computers in schools (while keeping down the pay of teachers so much that there are shortages? Do you think it will stop sending governors of state schools glossy pamphlets about insisting that computers are used in their schools as much as possible?" In this study, therefore, PISA looks well beyond educational attainment, and also includes school demographics, such as whether it is a public or private school, has large or small classes, or has access or not to technological resources. Finally, it does measure student information-their family background, access to books and computers and parental support as well. The PISA survey departs from previous surveys in disregarding the stated curricula of the schools being measured. Therefore, the conclusion is not surprising, nor even wrong for him to consider independently of any parental or teacher support, considered without reference to the software running on it, considered without reference to student attitudes and interests, does not positively impact an education. Finally, he focus on missing the reporting of results

  16. Understanding delusions.

    Science.gov (United States)

    Sedler, M J

    1995-06-01

    Delusions traditionally have been considered as fixed, false beliefs, born of morbidity. Whereas this definition serves to orient the clinician to the phenomena at hand, each element breaks down under scrutiny. It has been shown that delusions are not necessarily false, although in some sense they are discordant with reality. When delusions coincide with actual events their judgements can be shown to be independent of this evidential basis; when they refer to disorders of experience, such as first rank symptoms, the experience usually contains a distorted meaning. The supposition that delusions are a variety of belief has itself been questioned. On the one hand, they do not always refer in a meaningful way to anything, or when they do they fail to function as evaluative judgments; instead, delusions are experienced subjectively in ways that are characteristic of knowing rather than believing. On the other hand, delusions are not ascertained clinically by surveying the patient's belief system; rather their failure to achieve the status of objective knowledge leads to the post hoc relegation of delusions to the epistemologic waste basket of beliefs. To treat delusions as necessarily the product of morbidity is essentially tautologous insofar as delusions are, by definition, pathologic; that is, as defective judgments delusions are not simply erroneous, they are disordered. Finally, the fixity of delusions is an empirical matter and varies widely. Underlying this perceived intractability, however, are the subjective certainty and incorrigibility that Jaspers identified and which Spitzer has recast in the form of "epistemological asymmetry" misapplied to external reality. Although delusions typically have been recognized and categorized according to their manifest content, these formal considerations are crucial to understanding the nature of delusions. PMID:7659597

  17. Centered Pyramids

    OpenAIRE

    Brigger, P.; F. Müller; Illgner, K.; Unser, M.

    1999-01-01

    Quadtree-like pyramids have the advantage of resulting in a multiresolution representation where each pyramid node has four unambiguous parents. Such a centered topology guarantees a clearly defined up-projection of labels. This concept has been successfully and extensively used in applications of contour detection, object recognition and segmentation. Unfortunately, the quadtree-like type of pyramid has poor approximation powers because of the employed piecewise-constant image model. This pa...

  18. IRASM Center

    International Nuclear Information System (INIS)

    IRASM is a national center for radiation processing developed around an industrial Co60 gamma irradiator. Being a department in an R and D national institute, IRASM Center is dealing with radiation treatment, pre/post microbiological control, validation of irradiation sterilization, detection of irradiated foodstuffs. Training is available for operators of new irradiation facilities focused on radiation technologies, dosimetry, sterilization, food treatment, conservation by irradiation of cultural heritage, quality assurance. Expertise on proper choosing the plastics for packaging versus dose is offered to the potential clients. IRASM Center is also involved in interdisciplinary applied research like chitosan treatment, sterile male technique or implementation of irradiation step in production of pharmaceuticals. All important activities: irradiation treatment, dosimetry, microbiology, detection of irradiated food, radioprotection, nuclear safety, physical protection. are performed in accordance with the proper standards in the frame of a certified quality management system. In this way Co60 industrial sources, a byproduct of certain nuclear power plants like Candu type, appear to be the key of a large technical and R and D domain. (authors)

  19. Understanding disruptions in tokamaks

    International Nuclear Information System (INIS)

    This paper describes progress achieved since 2007 in understanding disruptions in tokamaks, when the effect of plasma current sharing with the wall was introduced into theory. As a result, the toroidal asymmetry of the plasma current measurements during vertical disruption event (VDE) on the Joint European Torus was explained. A new kind of plasma equilibria and mode coupling was introduced into theory, which can explain the duration of the external kink 1/1 mode during VDE. The paper presents first results of numerical simulations using a free boundary plasma model, relevant to disruptions.

  20. Needs of Sexual Assault Advocates in Campus-Based Sexual Assault Centers

    Science.gov (United States)

    Carmody, Dianne; Ekhomu, Jessica; Payne, Brian K.

    2009-01-01

    Most campuses have sexual assault crisis centers that are designed to assist victims and educate the college community about this crime. While much is known about sexual assault victimization patterns on college campuses, there is still a lack of understanding about the needs of those working to prevent sexual assault. In the current study, campus…

  1. Editorial Commentary: Helping Those Who Seek the Company of "Lord Stanley": Hockey Players and Hip Injuries Highlight the Current State and Future Challenges in Understanding, Treating, and Preventing Nonarthritic Hip Disease.

    Science.gov (United States)

    Christoforetti, John

    2016-09-01

    The state of the art in caring for athletic hip injuries requires comprehensive understanding of dynamic sport-specific biomechanical demands, accurate musculoskeletal diagnosis, and a mindset towards matching hip structure with functional demand at all levels of play. The sport of hockey presents a unique opportunity to review these fundamentals of modern management and illuminates the way towards future understanding of the cause of common nonarthritic hip conditions. PMID:27594336

  2. Multi-Dimensional Impact of the Public-Private Center for Translational Molecular Medicine (CTMM) in the Netherlands: Understanding New 21(st) Century Institutional Designs to Support Innovation-in-Society.

    Science.gov (United States)

    Steuten, Lotte M

    2016-05-01

    Knowledge translation is at the epicenter of 21st century life sciences and integrative biology. Several innovative institutional designs have been formulated to cultivate knowledge translation. One of these organizational innovations has been the Center for Translational Molecular Medicine (CTMM), a multi-million public-private partnership in the Netherlands. The CTMM aims to accelerate molecular diagnostics and imaging technologies to forecast disease susceptibilities in healthy populations and early diagnosis and personalized treatment of patients. This research evaluated CTMM's impact on scientific, translational, clinical, and economic dimensions. A pragmatic, operationally-defined process indicators approach was used. Data were gathered from CTMM administrations, through a CTMM-wide survey (n = 167) and group interviews. We found that the CTMM focused on disease areas with high human, clinical, and economic burden to society (i.e., oncology, cardiovascular, neurologic, infection, and immunity diseases). CTMM displayed a robust scientific impact that rests 15%-80% above international reference values regarding publication volume and impact. Technology translation to the clinic was accelerated, with >50% of projects progressing from pre-clinical development to clinical testing within 5 years. Furthermore, CTMM has generated nearly 1500 Full Time Equivalent (FTE) of translational R&D capacity. Its positive impact on translational, (future) clinical, and economic aspects is recognized across all surveyed stakeholders. As organizational innovation is increasingly considered critical to forge linkages between life sciences discoveries and innovation-in-society, lessons learned from this study may inform other institutions with similar objectives such as the Clinical and Translational Science Awards (CTSA) Program of the National Institutes of Health (NIH) in the United States. PMID:27195965

  3. Understanding Pregnancy and Birth Issues

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Pregnancy and Birth Issues Past Issues / Winter 2008 Table ... turn Javascript on. What is a High-Risk Pregnancy? All pregnancies involve a certain degree of risk ...

  4. National Health Information Center

    Science.gov (United States)

    ... ODPHP National Health Information Center National Health Information Center The National Health Information Center (NHIC) is sponsored ... interest View the NHO calendar . Federal Health Information Centers and Clearinghouses Federal Health Information Centers and Clearinghouses ...

  5. Internet gaming addiction: current perspectives.

    Science.gov (United States)

    Kuss, Daria J

    2013-01-01

    In the 2000s, online games became popular, while studies of Internet gaming addiction emerged, outlining the negative consequences of excessive gaming, its prevalence, and associated risk factors. The establishment of specialized treatment centers in South-East Asia, the US, and Europe reflects the growing need for professional help. It is argued that only by understanding the appeal of Internet gaming, its context, and neurobiologic correlates can the phenomenon of Internet gaming addiction be understood comprehensively. The aim of this review is to provide an insight into current perspectives on Internet gaming addiction using a holistic approach, taking into consideration the mass appeal of online games, the context of Internet gaming addiction, and associated neuroimaging findings, as well as the current diagnostic framework adopted by the American Psychiatric Association. The cited research indicates that the individual's context is a significant factor that marks the dividing line between excessive gaming and gaming addiction, and the game context can gain particular importance for players, depending on their life situation and gaming preferences. Moreover, the cultural context is significant because it embeds the gamer in a community with shared beliefs and practices, endowing their gaming with particular meaning. The cited neuroimaging studies indicate that Internet gaming addiction shares similarities with other addictions, including substance dependence, at the molecular, neurocircuitry, and behavioral levels. The findings provide support for the current perspective of understanding Internet gaming addiction from a disease framework. The benefits of an Internet gaming addiction diagnosis include reliability across research, destigmatization of individuals, development of efficacious treatments, and the creation of an incentive for public health care and insurance providers. The holistic approach adopted here not only highlights empirical research that

  6. Understanding Memory Loss

    Science.gov (United States)

    ... Referral Center Alzheimer's Disease Education and Referral Center Alzheimer's Disease Education and Referral Center Home About Alzheimer’s Alzheimer's Basics Causes Symptoms Diagnosis Treatment Caregiving Other Dementias Publications FAQs ...

  7. Precision Joining Center

    Energy Technology Data Exchange (ETDEWEB)

    Powell, J.W.; Westphal, D.A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10--12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of US industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  8. The Japanese science education centers.

    Science.gov (United States)

    Glass, B

    1966-10-14

    These six Japanese science education centers signify a sweeping reform of elementary and secondary school science teaching. They achieve their striking results because they are established on a permanent, local basis and are supported mainly by the local boards of education. They have avoided control by pedagogues and specialists in "education." Instead, they are operated by trained scientists and experienced school teachers who work together to devise programs specially suited to the needs of their teachers. With small and practicable steps, the teachers improve their understanding of methods which they can readily test in their own classrooms rooms and laboratories. The laboratory equipment in the science education centers is only slightly superior to that which the teachers have in their own schools, but superior enough to make them desire to improve their own facilities. Major facilities, such as x-ray machines, electron microscopes, telescopes (15-cm), and machine shops, as well as good working collections of minerals and fossils, and adequate greenhouses, permit the teachers to work with more expensive equipment, to gain a firsthand knowledge of its operation, and to bring groups of students to the center to observe what such instruments make possible. The use of American experimental course content improvement programs is widespread. Every science education center I visited is using PSSC, CHEMS, CBA, BSCS, or ESCP materials and studying the philosophy of these programs. Yet no center is entirely dependent on these programs, but uses them critically to supplement and improve its own courses. The emphasis is on good laboratory and field teaching as a basis for understanding scientific methods and concepts. Science as investigation and inquiry, instead of treatment solely as an authoritative body of facts, is coming into its own. The few defects of the science education centers of Japan inhere in the educational situation itself. The centers are at present

  9. Energy Materials Center at Cornell: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Abruña, Héctor [Cornell University; Mutolo, Paul F [Cornell University

    2015-01-02

    The mission of the Energy Materials Center at Cornell (emc2) was to achieve a detailed understanding, via a combination of synthesis of new materials, experimental and computational approaches, of how the nature, structure, and dynamics of nanostructured interfaces affect energy conversion and storage with emphasis on fuel cells, batteries and supercapacitors. Our research on these systems was organized around a full system strategy for: • the development and improved performance of materials for both electrodes at which storage or conversion occurs • understanding their internal interfaces, such as SEI layers in batteries and electrocatalyst supports in fuel cells, and methods for structuring them to enable high mass transport as well as high ionic and electronic conductivity • development of ion-conducting electrolytes for batteries and fuel cells (separately) and other separator components, as needed • development of methods for the characterization of these systems under operating conditions (operando methods) Generally, our work took industry and DOE report findings of current materials as a point of departure to focus on novel material sets for improved performance. In addition, some of our work focused on studying existing materials, for example observing battery solvent degradation, fuel cell catalyst coarsening or monitoring lithium dendrite growth, employing in operando methods developed within the center.

  10. Understanding taxi travel patterns

    Science.gov (United States)

    Cai, Hua; Zhan, Xiaowei; Zhu, Ji; Jia, Xiaoping; Chiu, Anthony S. F.; Xu, Ming

    2016-09-01

    Taxis play important roles in modern urban transportation systems, especially in mega cities. While providing necessary amenities, taxis also significantly contribute to traffic congestion, urban energy consumption, and air pollution. Understanding the travel patterns of taxis is thus important for addressing many urban sustainability challenges. Previous research has primarily focused on examining the statistical properties of passenger trips, which include only taxi trips occupied with passengers. However, unoccupied trips are also important for urban sustainability issues because they represent potential opportunities to improve the efficiency of the transportation system. Therefore, we need to understand the travel patterns of taxis as an integrated system, instead of focusing only on the occupied trips. In this study we examine GPS trajectory data of 11,880 taxis in Beijing, China for a period of three weeks. Our results show that taxi travel patterns share similar traits with travel patterns of individuals but also exhibit differences. Trip displacement distribution of taxi travels is statistically greater than the exponential distribution and smaller than the truncated power-law distribution. The distribution of short trips (less than 30 miles) can be best fitted with power-law while long trips follow exponential decay. We use radius of gyration to characterize individual taxi's travel distance and find that it does not follow a truncated power-law as observed in previous studies. Spatial and temporal regularities exist in taxi travels. However, with increasing spatial coverage, taxi trips can exhibit dual high probability density centers.

  11. Computer based human-centered display system

    Science.gov (United States)

    Still, David L. (Inventor); Temme, Leonard A. (Inventor)

    2002-01-01

    A human centered informational display is disclosed that can be used with vehicles (e.g. aircraft) and in other operational environments where rapid human centered comprehension of an operational environment is required. The informational display integrates all cockpit information into a single display in such a way that the pilot can clearly understand with a glance, his or her spatial orientation, flight performance, engine status and power management issues, radio aids, and the location of other air traffic, runways, weather, and terrain features. With OZ the information is presented as an integrated whole, the pilot instantaneously recognizes flight path deviations, and is instinctively drawn to the corrective maneuvers. Our laboratory studies indicate that OZ transfers to the pilot all of the integrated display information in less than 200 milliseconds. The reacquisition of scan can be accomplished just as quickly. Thus, the time constants for forming a mental model are near instantaneous. The pilot's ability to keep up with rapidly changing and threatening environments is tremendously enhanced. OZ is most easily compatible with aircraft that has flight path information coded electronically. With the correct sensors (which are currently available) OZ can be installed in essentially all current aircraft.

  12. Location of radiotherapy centers: An exploratory geographic analysis for Belgium

    International Nuclear Information System (INIS)

    Purpose. - The distance between the patient's home and a radiotherapy department may represent a hurdle for the patient and influence treatment choice. Therefore, it is necessary to check whether the geographical distribution of radiotherapy centers is in accordance with cancer incidence, taking also into account the cost of travelling to the radiotherapy department. The objective of this study is double; first, to map the current locations of radiotherapy centers across the country and second, to evaluate the observed spatial disparities with appropriate tools. Materials and methods. - A model of operational research (P-median) is used to suggest the optimal locations and allocations and to compare them with the current situation. This is an exploratory study with simple inputs. It helps to better understand the current geographical distribution of radiotherapy centers in Belgium as well as its possible limitations. Results-conclusion. - It appears that the current situation is on the average acceptable in terms of accessibility to the service and that the method presents huge potentialities for decision making so as to yield a spatial system that is both efficient and equitable. (authors)

  13. The MAGIC Data Center

    OpenAIRE

    Reichardt, Ignasi; Rico, Javier; Carmona, Emiliano; Contreras, Jose Luis; Cortina, Juan; Firpo, Roger; Font, Lluis; Moralejo, Abelardo; Nieto, Daniel; Oya, Igor; Reyes, Raquel de los

    2009-01-01

    The MAGIC I telescope produces currently around 100TByte of raw data per year that is calibrated and reduced on-site at the Observatorio del Roque de los Muchachos (La Palma). Since February 2007 most of the data have been stored and further processed in the Port d'Informacio Cientifica (PIC), Barcelona. This facility, which supports the GRID Tier 1 center for LHC in Spain, provides resources to give the entire MAGIC Collaboration access to the reduced telescope data. It is expected that the ...

  14. IN EXPECTATION OF RELATIONSHIPS: CENTERING THEORIES AROUND ECOLOGICAL UNDERSTANDING

    Science.gov (United States)

    Over the last several decades, many educators and professionals in the design and planning fields have made a "turn to ecology," where "turn" means a shift in emphasis and priorities. From the publication of Design with Nature (McHarg 1969) to the publication of contemporary appr...

  15. Understanding the early cycling evolution behaviors for phase change memory application

    International Nuclear Information System (INIS)

    The RESET current of T-shaped phase change memory cells with 35 nm heating electrodes has been studied to understand the behavior of early cycling evolution. Results show that the RESET current has been significantly reduced after the early cycling evolution (1st RESET) operation. Compared the transmission electron microscope images, it is found that the hexagonal Ge2Sb2Te5 (GST) crystal grains are changed into the grains with face centered cubic structure after the early cycling evolution operation, which is taken as the major reason for the reduced RESET current, confirmed by a two-dimensional finite analysis and ab initio calculations

  16. Shape understanding system machine understanding and human understanding

    CERN Document Server

    Les, Zbigniew

    2015-01-01

    This is the third book presenting selected results of research on the further development of the shape understanding system (SUS) carried out by authors in the newly founded Queen Jadwiga Research Institute of Understanding. In this book the new term Machine Understanding is introduced referring to a new area of research aiming to investigate the possibility of building machines with the ability to understand. It is presented that SUS needs to some extent mimic human understanding and for this reason machines are evaluated according to the rules applied for the evaluation of human understanding. The book shows how to formulate problems and how it can be tested if the machine is able to solve these problems.    

  17. FEMA Current Disaster Declarations -shp

    Data.gov (United States)

    Department of Homeland Security — This dataset lists the current Disaster Declarations in Shapefile. This data was compiled and distributed by FEMA Mapping and Analysis Center (MAC). Metadata file...

  18. Bird Species and Climate Change. The Global Status Report. A synthesis of current scientific understanding of anthropogenic climate change impacts on global bird species now, and projected future effects

    International Nuclear Information System (INIS)

    The results of a global analysis of current and future impacts of climate change on birds are presented. The report reviews more than 200 research reports to assemble a clear and consistent picture of climatic risk to this important animal group, illustrated with numerous examples and case studies. It is found that: climate change now affects bird species' behaviour, ranges and population dynamics; some bird species are already experiencing strong negative impacts from climate change; and in future, subject to greenhouse gas emissions levels and climatic response, climate change will put large numbers of bird species at risk of extinction, with estimates of extinction rates varying from 2 to 72%, depending on the region, climate scenario and potential for birds to shift to new habitat

  19. Natural Arabic language text understanding

    OpenAIRE

    Al-Khonaizi, Mohammed Taqi

    1999-01-01

    The most challenging part of natural language understanding is the representation of meaning. The current representation techniques are not sufficient to resolve the ambiguities, especially when the meaning is to be used for interrogation at a later stage. Arabic language represents a challenging field for Natural Language Processing (NLP) because of its rich eloquence and free word order, but at the same time it is a good platform to capture understanding because of its rich computational, m...

  20. Internet gaming addiction: current perspectives

    Directory of Open Access Journals (Sweden)

    Kuss DJ

    2013-11-01

    Full Text Available Daria J KussPsychology Research and Behavior Management, Birmingham City University, Birmingham, UKAbstract: In the 2000s, online games became popular, while studies of Internet gaming addiction emerged, outlining the negative consequences of excessive gaming, its prevalence, and associated risk factors. The establishment of specialized treatment centers in South-East Asia, the US, and Europe reflects the growing need for professional help. It is argued that only by understanding the appeal of Internet gaming, its context, and neurobiologic correlates can the phenomenon of Internet gaming addiction be understood comprehensively. The aim of this review is to provide an insight into current perspectives on Internet gaming addiction using a holistic approach, taking into consideration the mass appeal of online games, the context of Internet gaming addiction, and associated neuroimaging findings, as well as the current diagnostic framework adopted by the American Psychiatric Association. The cited research indicates that the individual's context is a significant factor that marks the dividing line between excessive gaming and gaming addiction, and the game context can gain particular importance for players, depending on their life situation and gaming preferences. Moreover, the cultural context is significant because it embeds the gamer in a community with shared beliefs and practices, endowing their gaming with particular meaning. The cited neuroimaging studies indicate that Internet gaming addiction shares similarities with other addictions, including substance dependence, at the molecular, neurocircuitry, and behavioral levels. The findings provide support for the current perspective of understanding Internet gaming addiction from a disease framework. The benefits of an Internet gaming addiction diagnosis include reliability across research, destigmatization of individuals, development of efficacious treatments, and the creation of an incentive

  1. Understanding Children's Work in Yemen

    OpenAIRE

    UCW

    2003-01-01

    The current report was developed under the aegis of a joint ILO/World Bank/UNICEF project “Understanding Children's Work” in Yemen. It provides an overview of the child work phenomenon in Yemen – its extent and nature, its determinants, its consequences on health and education, and national responses to it. The report serves two important UCW project objectives in the country. First, it helps provide a common analytical understanding of child work, that can be used to inform the current activ...

  2. The weak currents

    International Nuclear Information System (INIS)

    The main facts known on the structure of the weak hadronic current are given. An attempt is made to elucidate the physical meaning of different hypotheses such as C.V.C., PCAC, SU(3) and angle theta, chiral algebra, which have led to progress in the understanding of weak interactions. The central problem to overcome in order to specify the structure of the hadronic current is the fact that gaps remain in the knowledge of strong interactions. However a solution has been found by assuming that the weak current is a combination of the currents associated with exact or approximate symmetries of strong interactions

  3. Spin current

    CERN Document Server

    Valenzuela, Sergio O; Saitoh, Eiji; Kimura, Takashi

    2012-01-01

    In a new branch of physics and technology called spin-electronics or spintronics, the flow of electrical charge (usual current) as well as the flow of electron spin, the so-called 'spin current', are manipulated and controlled together. This book provides an introduction and guide to the new physics and application of spin current.

  4. Marine organism concentrations, carbonate chemistry variables, and nutrient concentrations from Atlantis ecosystem model simulation output in the California Current from 2013-01-01 to 2053-12-31 to understand vulnerability of California current food webs and economics to ocean acidification (NCEI Accession 0131198)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This archival package contains the model output of a study to evaluate likely economic and ecological outcomes of ocean acidification in the California Current....

  5. Call Center ist nicht gleich Call Center

    OpenAIRE

    Baumgartner, Marc; Udris, Ivars

    2005-01-01

    Untersuchungen in 14 Schweizer Call Centers erbrachten vier Call Center-Typen, die sich hinsichtlich Arbeitstätigkeiten und Kommunikationsrichtung voneinander unterscheiden: (a) Beratungs- und Beschwerdemanagement, (b) Informationsmanagement, (c) Auftragsmanagement und (d) Kunden- und Kampagnenmanagement. Dies hat auch Auswirkungen auf die Personalstruktur, -selektion und -entwicklung der Call Center. Es wird der Frage nachgegangen, welche Kompetenzanforderungen in den unterschiedlichen Call ...

  6. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Role in Cancer Research Intramural Research Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National ... Role in Cancer Research Intramural Research Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National ...

  7. Utton Center Scientific and Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Marilyn C. O’Leary

    2006-07-01

    Final Report of DOE grant to the Utton Transboundary Resources Center at University of New Mexico School of Law supporting prevention and management of transboundary water conflicts. Describes work of Utton Center and refers to three other documents reported separately. Includes brief description of multidisciplinary collaborative process, understanding cultural values of water and a model water compact.

  8. The 10th Anniversary Of Daejeon Environmental Technology Development Center

    International Nuclear Information System (INIS)

    This book describes the Daejeon Environment Technology Development Center with pictures for ten years. It also introduces the purpose of the foundation and background of center, structure of the center, main project and role of the center, center logo, current situation of cost of project, research business for 10 years, business supporting the environmental corporate, environment education, public relations activity and vision and prospect of the Daejeon Environmental Technology Development Center.

  9. Understanding Defense Mechanisms.

    Science.gov (United States)

    Cramer, Phebe

    2015-12-01

    Understanding defense mechanisms is an important part of psychotherapy. In this article, we trace the history of the concept of defense, from its origin with Freud to current views. The issue of defense as an unconscious mechanism is examined. The question of whether defenses are pathological, as well as their relation to pathology, is discussed. The effect of psychotherapy on the use of defenses, and their relation to a therapeutic alliance is explored. A series of empirical research studies that demonstrate the functioning of defense mechanisms and that support the theory is presented. Research also shows that as part of normal development, different defenses emerge at different developmental periods, and that gender differences in defense use occur. PMID:26583439

  10. Directions in Center Director Training

    Science.gov (United States)

    Bloom, Paula Jorde; Vinci, Yasmina; Rafanello, Donna; Donohue, Chip

    2011-01-01

    Exchange invited some of the leading trend watchers in the arena of director training to share their insights on the current state and future directions in this country. This article presents the authors' insights on the directions in center director training. They also share their views on whether the amount of and quality of training out there…

  11. Supernova Science Center

    Energy Technology Data Exchange (ETDEWEB)

    S. E. Woosley

    2008-05-05

    The Supernova Science Center (SNSC) was founded in 2001 to carry out theoretical and computational research leading to a better understanding of supernovae and related transients. The SNSC, a four-institutional collaboration, included scientists from LANL, LLNL, the University of Arizona (UA), and the University of California at Santa Cruz (UCSC). Intitially, the SNSC was funded for three years of operation, but in 2004 an opportunity was provided to submit a renewal proposal for two years. That proposal was funded and subsequently, at UCSC, a one year no-cost extension was granted. The total operational time of the SNSC was thus July 15, 2001 - July 15, 2007. This document summarizes the research and findings of the SNSC and provides a cummulative publication list.

  12. Industrial Assessment Center

    Energy Technology Data Exchange (ETDEWEB)

    J. Kelly Kissock; Becky Blust

    2007-04-17

    The University of Dayton (UD) performed energy assessments, trained students and supported USDOE objectives. In particular, the UD Industrial Assessment Center (IAC) performed 96 industrial energy assessment days for mid-sized manufacturers. The average identified and implemented savings on each assessment were $261,080 per year and $54,790 per year. The assessments served as direct training in industrial energy efficiency for 16 UD IAC students. The assessments also served as a mechanism for the UD IAC to understand manufacturing energy use and improve upon the science of manufacturing energy efficiency. Specific research results were published in 16 conference proceedings and journals, disseminated in 22 additional invited lectures, and shared with the industrial energy community through the UD IAC website.

  13. Citizen centered design

    Directory of Open Access Journals (Sweden)

    Ingrid Mulder

    2015-11-01

    Full Text Available Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with bottom-up social innovation to reach meaningful design. The biggest challenge is indeed to embrace a new collaborative attitude, a participatory approach, and to have the proper infrastructure that supports this social fabric. Participatory design and transition management are future-oriented, address people and institutions. Only through understanding people in context and the corresponding dynamics, one is able to design for liveable and sustainable urban environments, embracing the human scale.

  14. Engagement: Looking beyond the mirror to understand action understanding.

    Science.gov (United States)

    Reddy, Vasudevi; Uithol, Sebo

    2016-03-01

    In this paper, we argue that the current focus on mirroring as the route to explaining the development of action understanding is misleading and problematic. It facilitates a fundamentally spectatorial stance, ignoring engagement and dialogue; it focuses on similarity between self and other and neglects difference; and it succumbs to the static terminology of mechanism rather than a dynamic language of process. Contrary to this view, dialogic exchanges are evident from the start of life, revealing infants' ability to engage with and respond appropriately to actions that are outside their own motor repertoire. We suggest that engagement rather than mirroring better accounts for many current findings in action understanding. The neurological evidence to date shows that action perception involves a process of continuous synchronization and change, suggesting that it might be more fruitful for research and theory to look beyond mirroring and instead adopt dynamic processual explanations of action understanding within interaction. PMID:26234724

  15. Transplant Center Search Form

    Science.gov (United States)

    ... Your Story Give Us Feedback - A + A Transplant Center Search Form Welcome to the Blood & Marrow Transplant ... centers for patients with a particular disease. Transplant Center login Username: * Password: * Request new password Join BMT ...

  16. Understanding and Supporting Window Switching

    NARCIS (Netherlands)

    Tak, S.

    2011-01-01

    Switching between windows on a computer is a frequent activity, but finding and switching to the target window can be inefficient. This thesis aims to better un-derstand and support window switching. It explores two issues: (1) the lack of knowledge of how people currently interact with and switch b

  17. Womens Business Center

    Data.gov (United States)

    Small Business Administration — Women's Business Centers (WBCs) represent a national network of nearly 100 educational centers throughout the United States and its territories, which are designed...

  18. Understanding Blood Counts

    Science.gov (United States)

    ... Lab and Imaging Tests Understanding Blood Counts Understanding Blood Counts Understanding Blood Counts SHARE: Print Glossary Blood cell counts give ... your blood that's occupied by red cells. Normal Blood Counts Normal blood counts fall within a range ...

  19. University of Washington Center for Child Environmental Health Risks Research

    Data.gov (United States)

    Federal Laboratory Consortium — The theme of the University of Washington based Center for Child Environmental Health Risks Research (CHC) is understanding the biochemical, molecular and exposure...

  20. Current stabilizer

    International Nuclear Information System (INIS)

    A current stabilizer for supplying magnetic lens of β-monochromator at the electron energy up to 1 MeV is described. Stabilization method with use of reference high-stabilized source of direct voltage with switching-in loading (monochromator coil) to circuit of negative feedback of direct-current amplifier with high gain is chosen for stabilization of direct current. The range of current regulation is 0.5 A at available power up to 15 W. Current instability during 10 hour continuous work does not exceed 10-4% that makes it possible to provide instability of electron energy at the monochromator exit using 90Sr+90Y β-nucleide of not more than 10 -4% and number of electrons 2.5x10-4% respectively

  1. Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the Design and Operation of Multi-center Clinical Trials: a Qualitative Research Study

    OpenAIRE

    Eisenstein, Eric L.; Diener, Lawrence W.; Nahm, Meredith; Weinfurt, Kevin P.

    2010-01-01

    New technologies may be required to integrate the National Institutes of Health’s Patient Reported Outcome Management Information System (PROMIS) into multi-center clinical trials. To better understand this need, we identified likely PROMIS reporting formats, developed a multi-center clinical trial process model, and identified gaps between current capabilities and those necessary for PROMIS. These results were evaluated by key trial constituencies. Issues reported by principal investigators ...

  2. Artificial and self-assembled vortex-pinning centers in superconducting Ba(Fe1-xCox)2As2 thin films as a route to obtaining very high critical-current densities

    Science.gov (United States)

    Tarantini, C.; Lee, S.; Kametani, F.; Jiang, J.; Weiss, J. D.; Jaroszynski, J.; Folkman, C. M.; Hellstrom, E. E.; Eom, C. B.; Larbalestier, D. C.

    2012-12-01

    We report on the superior vortex pinning of single- and multilayer Ba(Fe1-xCox)2As2 thin films with self-assembled c-axis and artificially introduced ab-plane pins. Ba(Fe1-xCox)2As2 can accept a very high density of pins (15-20 vol %) without Tc suppression. The matching field is greater than 12 T, producing a significant enhancement of the critical current density Jc, an almost isotropic Jc(θ, 20 T) > 105 A/cm2, and global pinning force density Fp of ˜50 GN/m3. This scenario strongly differs from the high-temperature superconducting cuprates where the addition of pins without Tc suppression is limited to 2-4 vol %, leading to small HIrr enhancements and improved Jc only below 3-5 T.

  3. The MAGIC Data Center

    CERN Document Server

    Reichardt, Ignasi; Carmona, Emiliano; Contreras, Jose Luis; Cortina, Juan; Firpo, Roger; Font, Lluis; Moralejo, Abelardo; Nieto, Daniel; Oya, Igor; Reyes, Raquel de los

    2009-01-01

    The MAGIC I telescope produces currently around 100TByte of raw data per year that is calibrated and reduced on-site at the Observatorio del Roque de los Muchachos (La Palma). Since February 2007 most of the data have been stored and further processed in the Port d'Informacio Cientifica (PIC), Barcelona. This facility, which supports the GRID Tier 1 center for LHC in Spain, provides resources to give the entire MAGIC Collaboration access to the reduced telescope data. It is expected that the data volume will increase by a factor 3 after the start-up of the second telescope, MAGIC II. The project to improve the MAGIC Data Center to meet these requirements is presented. In addition, we discuss the production of high level data products that will allow a more flexible analysis and will contribute to the international network of astronomical data (European Virtual Observatory). For this purpose, we will have to develop a new software able to adapt the analysis process to different data taking conditions, such as ...

  4. Students' understanding of trigonometric functions

    Science.gov (United States)

    Weber, Keith

    2005-10-01

    In this article students' understanding of trigonometric functions in the context of two college trigonometry courses is investigated. The first course was taught by a professor unaffiliated with the study in a lecture-based course, while the second was taught using an experimental instruction paradigm based on Gray and Tall's (1994) notion of procept and current process-object theories of learning. Via interviews and a paper-and-pencil test, I examined students' understanding of trigonometric functions for both classes. The results indicate that the students who were taught in the lecture-based course developed a very limited understanding of these functions. Students who received the experimental instruction developed a deep understanding of trigonometric functions.

  5. Expansion of the Center for Network Innovation and Experimentation (CENETIX) network to a worldwide presence

    OpenAIRE

    Farrell, Michael M.

    2006-01-01

    This thesis will focus directly on the enhancement of an established Network Operations Center (NOC) and will extend the capabilities of this asset beyond its present scope. By defining the current infrastructure using present network management tools it will provide a better understanding of the present network, as well as enhance management for future field experiments. Finally, extending the CENETIX network via implementation of Virtual Private Networking (VPN) technology will allow othe...

  6. The Scientific Data Management Center

    OpenAIRE

    Shoshani, Arie

    2006-01-01

    With the increasing volume and complexity of data produced by ultra-scale simulations and high-throughput experiments, understanding the science is largely hampered by the lack of comprehensive, end-to-end data management solutions ranging from initial data acquisition to final analysis and visualization. The Scientific Data Management (SDM) Center is bringing a set of advanced data management technologies to DOE scientists in various application domains including astrophysics, climate, ...

  7. Student Success Center Toolkit

    Science.gov (United States)

    Jobs For the Future, 2014

    2014-01-01

    "Student Success Center Toolkit" is a compilation of materials organized to assist Student Success Center directors as they staff, launch, operate, and sustain Centers. The toolkit features materials created and used by existing Centers, such as staffing and budgeting templates, launch materials, sample meeting agendas, and fundraising…

  8. Beyond consent--improving understanding in surgical patients.

    LENUS (Irish Health Repository)

    Mulsow, Jürgen J W

    2012-01-01

    Little is known of the actual understanding that underlies patient choices with regard to their surgical treatment. This review explores current knowledge of patient understanding and techniques that may be used to improve this understanding.

  9. Valuation of Understanding

    DEFF Research Database (Denmark)

    Wiberg, Merete

    be. Understanding is to be discussed as a phenomenon which in its definition is relative to the paradigm of educational thinking in which it is embedded. Paradigms of valuation of understanding in higher education will be viewed from two perspectives: An anglosaxon curriculum studies tradition and a...... valuation of understanding might be different. The difference between these two paradigms are to be discussed with specific reference to how these different ideas of ideals of structures of understanding might influence valuation of understanding and how valuation of understanding has consequences for...... teaching and learning. Furthermore, the way valuation of understanding is conducted might have consequences for the formation of students....

  10. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... History of NCI Contributing to Cancer Research Senior Leadership Director Previous Directors NCI Organization Divisions, Offices & Centers Advisory Boards & Groups Budget & Appropriations ...

  11. 77 FR 14707 - Vet Center Services

    Science.gov (United States)

    2012-03-13

    ... Records 64VA15, ``Readjustment Counseling Service Vet Center Program,'' most recently amended at 74 FR... DEPARTMENT OF VETERANS AFFAIRS 38 CFR Part 17 RIN 2900-AN92 Vet Center Services AGENCY: Department of Defense... (VA) proposes to establish in regulation the readjustment counseling currently provided in VA's...

  12. Changing the batch system in a Tier 1 computing center: why and how

    International Nuclear Information System (INIS)

    At the Italian Tierl Center at CNAF we are evaluating the possibility to change the current production batch system. This activity is motivated mainly because we are looking for a more flexible licensing model as well as to avoid vendor lock-in. We performed a technology tracking exercise and among many possible solutions we chose to evaluate Grid Engine as an alternative because its adoption is increasing in the HEPiX community and because it's supported by the EMI middleware that we currently use on our computing farm. Another INFN site evaluated Slurm and we will compare our results in order to understand pros and cons of the two solutions. We will present the results of our evaluation of Grid Engine, in order to understand if it can fit the requirements of a Tier 1 center, compared to the solution we adopted long ago. We performed a survey and a critical re-evaluation of our farming infrastructure: many production softwares (accounting and monitoring on top of all) rely on our current solution and changing it required us to write new wrappers and adapt the infrastructure to the new system. We believe the results of this investigation can be very useful to other Tier-ls and Tier-2s centers in a similar situation, where the effort of switching may appear too hard to stand. We will provide guidelines in order to understand how difficult this operation can be and how long the change may take.

  13. NASA Human Health and Performance Center (NHHPC)

    Science.gov (United States)

    Davis, Jeffery R.

    2010-01-01

    This slide presentation reviews the purpose, potential members and participants of the NASA Human Health and Performance Center (NHHPC). Included in the overview is a brief description of the administration and current activities of the NHHPC.

  14. [Policy, planning and health management: the current understanding].

    Science.gov (United States)

    Paim, Jairnilson Silva; Teixeira, Carmen Fontes

    2006-08-01

    This work provides a literature review of Policy, Planning and Health Management between 1974 and 2005. Information is presented from previous research and publications, incorporating the production contained within the LILACS database from the last five years. The emergence of studies in these sub-themes is described in an attempt to associate them with political circumstances, with particular emphasis on: the Sanitary Reform Process, the construction of the National Health System and the reorientation of health practices. The particularities of the production in this field are discussed and the need for historical and epistemological work in Brazil is emphasized. The practical challenges impose techno-scientific expertise and, primarily, socio-political militancy on individual and collective subjects. PMID:16924306

  15. Pain and sex hormones: a review of current understanding.

    Science.gov (United States)

    Maurer, Adrian J; Lissounov, Alexei; Knezevic, Ivana; Candido, Kenneth D; Knezevic, Nebojsa Nick

    2016-05-01

    Multiple epidemiologic studies have demonstrated an increased prevalence for women in several chronic pain disorders. Clinical and experimental investigations have consistently demonstrated sex-specific differences in pain sensitivity and pain threshold. Even though the underlying mechanisms responsible for these differences have not yet been elucidated, the logical possibility of gonadal hormone influence on nociceptive processing has garnered recent attention. In this review, we evaluated the complex literature regarding gonadal hormones and their influence on pain perception. We reviewed the numerous functions of gonadal hormones, discussed the influence of these hormones on several common chronic pain syndromes (migraine, tension and cluster headaches, fibromyalgia, temporomandibular syndrome, rheumatoid arthritis and back pain, among others), and have attempted to draw conclusions from the available data. PMID:26983893

  16. Telocytes in the reproductive organs: Current understanding and future challenges.

    Science.gov (United States)

    Cretoiu, Dragos; Cretoiu, Sanda Maria

    2016-07-01

    Over the past decades, we were witnessing spectacular molecular medicine advances. However, many of the reproductive medicine problems, such as fertility issues and premature birth still represent major challenges for obstetrics and gynecology worldwide. A new cell population - the telocytes (TCs) - were described in the interstitial space of many organs, and their possible implications in many important physiological and pathological processes should not be overlooked. In this article, we present a historical perspective outlining the landmarks in the discovery, evolution and achievements in the field of TCs over the last ten years. We focused on the potential roles of TCs in morphogenesis and maintenance of the normal three-dimensional architecture of tissues, in controlling of the stem cell microenvironment, as having anti-inflammatory and cancer-suppressing properties, participating in the immune surveillance, all mediated by direct homo- and heterocellular junctions or indirectly by extracellular vesicle release. Here, we overview the advances on TCs research in the reproductive organs (uterus and fallopian tube), accessory reproductive organs of female (mammary glands) and the temporary endocrine organ-placenta. PMID:27021165

  17. Athlete leadership in sport teams: Current understanding and future directions

    OpenAIRE

    Cotterill, Stewart T.; Fransen, Katrien

    2016-01-01

    Leadership is a fundamental aspect of sports performance, particularly within team sport environments. Over the past 25 years there has been significant research exploring the role of the coach/manager in this regard. However, this only represents one aspect of leadership within the sporting domain. Equally important, although far less examined is the concept of athlete leadership. The role of athlete leaders, both formal (e.g., the captain) and informal (such as motivators and cultural a...

  18. Current issues in the understanding of consumer food choice

    DEFF Research Database (Denmark)

    Grunert, Klaus G.

    2002-01-01

    brands and labels are mentioned as possible ways to improve this situation. Genetic modification is used as an example of the way in which consumer attitudes to product technologies can influence quality perceptions and food choice. Food quality is to an increasing extent characterised by so......Consumer food choice is framed in terms of the formation of quality expectations before and quality experience after the purchase. For the formation of quality expectations, lack of consumer ability to form expectations that will be predictive of later experience is mentioned as a problem, and...... quality after the purchase, the role of home production - turning products into meals - is mentioned as important, but underresearced topic. Finally, differences in consumer behaviour between normal situations and situations of food crises are addressed. Udgivelsesdato: AUG...

  19. Current Understanding of the Genetic Architecture of Rhegmatogenous Retinal Detachment.

    Science.gov (United States)

    Johnston, Timothy; Chandra, Aman; Hewitt, Alex W

    2016-06-01

    Rhegmatogenous retinal detachment (RRD) is a common and potentially blinding surgical retinal disease. While the precise molecular mechanisms leading to RRD are poorly understood, there is an increasing body of literature supporting the role of heritable factors in the pathogenesis of the condition. Much work has been undertaken investigating genes important in syndromic forms of RRD (e.g., Stickler, Wagner Syndrome, etc.) and research pertaining to genetic investigations of idiopathic or non-syndromic RRD has also recently been reported. To date, at least 12 genetic loci have been implicated in the development of syndromes of which RRD is a feature. A recent GWAS identified five loci implicated in the development of idiopathic RRD.This article provides an overview of the genetic mechanisms of both syndromic and idiopathic RRD. The genetics of predisposing conditions, such as myopia and lattice degeneration, are also discussed. PMID:26757352

  20. Gifted Male Readers: Current Understandings and Suggestions for Future Research

    Science.gov (United States)

    Pagnani, Alexander R.

    2013-01-01

    Research literature concerning gifted male readers relies primarily on more extensive bodies of work regarding gifted males and male readers. Studied as a whole, the two halves portray a worrisome state of affairs for gifted male readers, who lag behind their female counterparts in the same patterns found across the ability spectrum. This literacy…

  1. Current understanding of increased insulin sensitivity after exercise - emerging candidates

    DEFF Research Database (Denmark)

    Maarbjerg, Stine Just; Sylow, Lykke; Richter, Erik

    2011-01-01

    Exercise counteracts insulin resistance and improves glucose homeostasis in many ways. Apart from increasing muscle glucose uptake quickly, exercise also clearly increases muscle insulin sensitivity in the post exercise period. This review will focus on the mechanisms responsible for this increased...... signaling component in the insulin signaling pathway such as aPKC, Rac1, TBC1D4 and TBC1D1 have been described. These are all affected by both insulin and exercise which means that they are likely converging points in promoting GLUT4 translocation and therefore possible candidates for regulating insulin...... sensitivity after exercise. Whereas TBC1D1 does not appear to regulate insulin sensitivity after exercise, correlative evidence in contrast suggests TBC1D4 to be a relevant candidate. Little is known about aPKC and Rac1 in relation to insulin sensitivity after exercise. Besides mechanisms involved in...

  2. Food Addiction: Current Understanding and Implications for Regulation and Research

    OpenAIRE

    Sorenson, Margareta

    2014-01-01

    The idea that some processed foods can be addictive has gained support in recent years. Animal and human studies show extensive overlap between the neuronal signaling involved in palatable food consumption and drug addiction. A growing number of individuals also repor being unable to stop consuming certain foods despite repeated efforts, and consuming them to feel better emotionally, rather than to satisfy hunger. While food addiction can contribute to overconsumption of calories and exces...

  3. Current understanding of photoelectron spectra in plutonium systems

    Czech Academy of Sciences Publication Activity Database

    Havela, L.; Shick, Alexander; Gouder, T.

    2009-01-01

    Roč. 385, č. 1 (2009), 28-30. ISSN 0022-3115 R&D Projects: GA ČR GA202/07/0644; GA MŠk OC 144 Institutional research plan: CEZ:AV0Z10100520 Keywords : electronic structure * electron correlations * photoemission Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.933, year: 2009

  4. Current Understanding of the Role of PPARγ in Gastrointestinal Cancers

    Directory of Open Access Journals (Sweden)

    Bing Zou

    2009-01-01

    Full Text Available Numerous studies have indicated that PPARγ plays multiple roles such as in inflammation, cell cycle control, cell proliferation, apoptosis, and carcinogenesis, thus PPARγ contributes to the homeostasis. Many in vitro studies have showed that ligand-induced activation of PPARγ possess antitumor effect in many cancers including CRC. However, the role of PPARγ in gastrointestinal cancers, especially in colorectal cancer, is rather controversial. Nevertheless, some recent studies with the positive results on the possible application of PPARγ ligands, such as Bezafibrate or Rosiglitazone in gastrointestinal cancers, have suggested a potential usefulness of PPARγ agonists in cancer prevention and therapy. In this review, the authors discuss the recent developments in the role of PPARγ in gastrointestinal cancers.

  5. New Research Center Will Free Chemistry from Earth's Bonds

    Science.gov (United States)

    2008-10-01

    operates the giant Robert C. Byrd Green Bank Telescope in West Virginia, which has been used to discover ten new interstellar molecules in the past three years, a record unmatched by any other telescope. The NRAO also is the North American partner in the international Atacama Large Millimeter/submillimeter Array (ALMA) project. ALMA is expected to provide an unprecedented ability to study interstellar chemistry when it goes online in 2012. "A central theme of chemistry is to understand how chemical reactions work. Most of our current knowledge of how molecules are formed came from laboratory experiments with solutions. However, in interstellar space, reactions occur in gases and on surfaces, such as on tiny cosmic dust grains. We're going to focus on studying these poorly-understood processes, and thus break chemistry out of our Earth-bound constraints," said Philip Jewell, Deputy Director of the NRAO, and one of the team members. "The combination of experimentalists, theoreticians and radio-telescope observers will allow quick feedback and testing of new ideas and better understanding of what we see in our own and other galaxies," said Anthony Remijan of the NRAO. The new center also will pursue an extensive educational effort, including student programs, new courses at UVa, and displays and outreach activities at the NRAO's Green Bank Science Center and other museums. The University of Virginia is a leading public research university with funding from the National Science Foundation and several other public and private funding organizations. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

  6. Current Options for Determining Fracture Union

    Directory of Open Access Journals (Sweden)

    Saam Morshed

    2014-01-01

    Full Text Available Determining whether a bone fracture is healed is one of the most important and fundamental clinical determinations made in orthopaedics. However, there are currently no standardized methods of assessing fracture union, which in turn has created significant disagreement among orthopaedic surgeons in both clinical and research settings. An extensive amount of research has been dedicated to finding novel and reliable ways of determining healing with some promising results. Recent advancements in imaging techniques and introduction of new radiographic scores have helped decrease the amount of disagreement on this topic among physicians. The knowledge gained from biomechanical studies of bone healing has helped us refine our tools and create more efficient and practical research instruments. Additionally, a deeper understanding of the molecular pathways involved in the bone healing process has led to emergence of serologic markers as possible candidates in assessment of fracture union. In addition to our current physician centered methods, patient-centered approaches assessing quality of life and function are gaining popularity in assessment of fracture union. Despite these advances, assessment of union remains an imperfect practice in the clinical setting. Therefore, clinicians need to draw on multiple modalities that directly and indirectly measure or correlate with bone healing when counseling patients.

  7. Understanding customer experience.

    Science.gov (United States)

    Meyer, Christopher; Schwager, Andre

    2007-02-01

    Anyone who has signed up for cell phone service, attempted to claim a rebate, or navigated a call center has probably suffered from a company's apparent indifference to what should be its first concern: the customer experiences that culminate in either satisfaction or disappointment and defection. Customer experience is the subjective response customers have to direct or indirect contact with a company. It encompasses every aspect of an offering: customer care, advertising, packaging, features, ease of use, reliability. Customer experience is shaped by customers' expectations, which largely reflect previous experiences. Few CEOs would argue against the significance of customer experience or against measuring and analyzing it. But many don't appreciate how those activities differ from CRM or just how illuminating the data can be. For instance, the majority of the companies in a recent survey believed they have been providing "superior" experiences to customers, but most customers disagreed. The authors describe a customer experience management (CEM) process that involves three kinds of monitoring: past patterns (evaluating completed transactions), present patterns (tracking current relationships), and potential patterns (conducting inquiries in the hope of unveiling future opportunities). Data are collected at or about touch points through such methods as surveys, interviews, focus groups, and online forums. Companies need to involve every function in the effort, not just a single customer-facing group. The authors go on to illustrate how a cross-functional CEM system is created. With such a system, companies can discover which customers are prospects for growth and which require immediate intervention. PMID:17345685

  8. The users centered design of a new digital fluorometer

    International Nuclear Information System (INIS)

    The fluorometer is an equipment used in chemical analysis laboratories, research institutes and nuclear fuel cycle companies. This equipment measures an unknown amount of uranium in ores, rivers, etc. The fluorometer functioning is based on the uranium fluorescence when submitted to the ultraviolet radiation incidence. The fluorescence is measured by an electronic optic system with optics filters, photomultiplier tube, and a current amplifier. The user centered design involves the user in the product development in all phases of the design process. Users are not simply consulted at the beginning of the design process and evaluated the system at the end; they are treated as partners throughout the design process. The user centered design emphasizes the needs and abilities of the users and improves the usability of the equipment. The activity centered design emphasizes the development of the equipment with a deep understanding of the users activities and of the current work practices of the users. The aim of this paper is to present a methodological framework that contributes to the design and evaluation of a new digital fluorometer towards an approach related to the users and their activities. This methodological framework includes users-based testing, interviews, questionnaires, human factors standards and guidelines, the users activity analysis and users satisfaction questionnaire. (author)

  9. The users centered design of a new digital fluorometer

    International Nuclear Information System (INIS)

    The fluorometer is the equipment used in chemical analysis laboratories, research institutes and nuclear fuel cycle companies. This equipment measures an unknown amount of uranium in ores, rivers, etc. The fluorometer functioning is based on the uranium fluorescence when submitted to the ultraviolet radiation incidence. The fluorescence is measured by an electronic optic system with optics filters, photomultiplier tube, and a current amplifier. The user centered design involves the user in the product development in all phases of the design process. Users are not simply consulted at the beginning of the design process and evaluated the system at the end; they are treated as partners throughout the design process. The user centered design emphasizes the needs and abilities of the users and improves the usability of the equipment. The activity centered design emphasizes the development of the equipment with a deep understanding of the users activities and of the current work practices of the users. The aim of this paper is to present a methodological framework that contributes to the design and evaluation of a new digital fluorometer towards an approach related to the users and their activities. This methodological framework includes users-based testing, interviews, questionnaires, human factors standards and guidelines, the users activity analysis and users satisfaction questionnaire. (author)

  10. Introduction to the S-BRITE Center at Purdue University

    OpenAIRE

    Connor, Robert

    2015-01-01

    Purdue University has partnered with INDOT and JTRP to develop a unique center that fills a growing need related to existing and aging steel bridges. The new center has been named the Steel Bridge Research, Inspection, Training, and Engineering Center (S-BRITE). Dr. Connor will provide an introduction to the center and on update on current progress, as well as highlight some of the current research associated with S-BRITE.

  11. Advancing Drought Understanding, Monitoring and Prediction

    Science.gov (United States)

    Mariotti, Annarita; Schubert, Siegfried D.; Mo, Kingtse; Peters-Lidard, Christa; Wood, Andy; Pulwarty, Roger; Huang, Jin; Barrie, Dan

    2013-01-01

    Having the capacity to monitor droughts in near-real time and providing accurate drought prediction from weeks to seasons in advance can greatly reduce the severity of social and economic damage caused by drought, a leading natural hazard for North America. The congressional mandate to establish the National Integrated Drought Information System (NIDIS; Public Law 109-430) in 2006 was a major impulse to develop, integrate, and provide drought information to meet the challenges posed by this hazard. Significant progress has been made on many fronts. On the research front, efforts by the broad scientific community have resulted in improved understanding of North American droughts and improved monitoring and forecasting tools. We now have a better understanding of the droughts of the twentieth century including the 1930s "Dust Bowl"; we have developed a broader array of tools and datasets that enhance the official North American Drought Monitor based on different methodologies such as state-of-the-art land surface modeling (e.g., the North American Land Data Assimilation System) and remote sensing (e.g., the evaporative stress index) to better characterize the occurrence and severity of drought in its multiple manifestations. In addition, we have new tools for drought prediction [including the new National Centers for Environmental Prediction (NCEP) Climate Forecast System, version 2, for operational prediction and an experimental National Multimodel Ensemble] and have explored diverse methodologies including ensemble hydrologic prediction approaches. Broad NIDIS-inspired progress is influencing the development of a Global Drought Information System (GDIS) under the auspices of the World Climate Research Program. Despite these advances, current drought monitoring and forecasting capabilities still fall short of users' needs, especially the need for skillful and reliable drought forecasts at regional and local scales. To tackle this outstanding challenging problem

  12. Classification of Simple Current Invariants

    CERN Document Server

    Gato-Rivera, Beatriz

    1991-01-01

    We summarize recent work on the classification of modular invariant partition functions that can be obtained with simple currents in theories with a center (Z_p)^k with p prime. New empirical results for other centers are also presented. Our observation that the total number of invariants is monodromy-independent for (Z_p)^k appears to be true in general as well. (Talk presented in the parallel session on string theory of the Lepton-Photon/EPS Conference, Geneva, 1991.)

  13. Understanding Mechanical Design with Respect to Manufacturability

    Science.gov (United States)

    Mondell, Skyler

    2010-01-01

    At the NASA Prototype Development Laboratory in Kennedy Space Center, Fl, several projects concerning different areas of mechanical design were undertaken in order to better understand the relationship between mechanical design and manufacturabiIity. The assigned projects pertained specifically to the NASA Space Shuttle, Constellation, and Expendable Launch Vehicle programs. During the work term, mechanical design practices relating to manufacturing processes were learned and utilized in order to obtain an understanding of mechanical design with respect to manufacturability.

  14. Neutral currents

    International Nuclear Information System (INIS)

    The evidence for the existence of weak neutral current has been a very controverted topics in the early 1970's, as well as the muon did in the 1930's. The history is very rich considering the evolution of the experimental techniques in high energy particle physics. The history of the discovery and the study of weak neutral current is reviewed. Later the quest of the intermediate vector boson continues with the decision of the community to build a large proton antiproton collider. (K.A.). 14 refs., 1 fig

  15. Understanding in mathematics

    CERN Document Server

    Sierpinska, Anna

    1994-01-01

    The concept of understanding in mathematics with regard to mathematics education is considered in this volume, the main problem for mathematics teachers being how to facilitate their students'' understanding of the mathematics being taught.

  16. Understanding Dyslexia (For Parents)

    Science.gov (United States)

    ... 5 Things to Know About Zika & Pregnancy Understanding Dyslexia KidsHealth > For Parents > Understanding Dyslexia Print A A ... be taught to become successful readers. Reading and Dyslexia Most kids begin learning to read by learning ...

  17. Understanding Identity and Organizations

    DEFF Research Database (Denmark)

    Christensen, Lars Thøger

    2013-01-01

    The article reviews the book "Understanding Identity and Organizations," by Kate Kenny, Andrea Whitle, and Hugh Wilmott.......The article reviews the book "Understanding Identity and Organizations," by Kate Kenny, Andrea Whitle, and Hugh Wilmott....

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Prognosis Questions to Ask about Your Diagnosis Research Understanding Cancer Prognosis Oncologist Anthony L. Back, M.D., ... find our information on Coping With Cancer helpful. Understanding Statistics About Survival Doctors estimate prognosis by using ...

  19. Models of natural language understanding.

    OpenAIRE

    Bates, M.

    1995-01-01

    This paper surveys some of the fundamental problems in natural language (NL) understanding (syntax, semantics, pragmatics, and discourse) and the current approaches to solving them. Some recent developments in NL processing include increased emphasis on corpus-based rather than example- or intuition-based work, attempts to measure the coverage and effectiveness of NL systems, dealing with discourse and dialogue phenomena, and attempts to use both analytic and stochastic knowledge. Critical ar...

  20. Understanding Intellectual Disability through Rasopathies

    OpenAIRE

    Alvaro, San Martín; Rafael, Pagani Mario

    2014-01-01

    Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that begins in early life during the developmental period. Currently the term intellectual disability is the preferred one. Although our understanding of the physiological basis of learning and learning disability is poor, a general idea is that such condition is quite permanent...

  1. COMPUTATIONAL SCIENCE CENTER

    International Nuclear Information System (INIS)

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to bring together

  2. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT, J.

    2006-11-01

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to

  3. Alzheimer's Disease Research Centers

    Science.gov (United States)

    ... Plan National Alzheimer's Project Act (NAPA) About ADEAR Alzheimer's Disease Research Centers The National Institute on Aging ... Repository for Alzheimer's Disease ADC Directory Arizona Arizona Alzheimer’s Disease Center/Sun Health Research Institute Eric Reiman, ...

  4. New Mexico Convention Centers

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset provides an initial version of the locations of convention centers in New Mexico, in point form, with limited attributes, compiled using available data...

  5. Day Care Centers

    Data.gov (United States)

    Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

  6. NIH Clinical Centers

    Data.gov (United States)

    Federal Laboratory Consortium — The NIH Clinical Center consists of two main facilities: The Mark O. Hatfield Clinical Research Center, which opened in 2005, houses inpatient units, day hospitals,...

  7. Tornadoes: A Center Approach.

    Science.gov (United States)

    Christman-Rothlein, Liz; Meinbach, Anita M.

    1981-01-01

    Information is given on how to put together a learning center. Discusses information and activity packets for a complete learning center on tornadoes including objectives, directions, materials, photographs of physical arrangements, and posttest. (DC)

  8. Center for Functional Nanomaterials

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Functional Nanomaterials (CFN) explores the unique properties of materials and processes at the nanoscale. The CFN is a user-oriented research center...

  9. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Safety Education Centers OnSafety Blog Neighborhood Safety Network Community Outreach Resource Center CO Poster Contest Toy Recall ... of the external site as its information collection practices may differ from ours. Linking to this external ...

  10. America's Blood Centers

    Science.gov (United States)

    ... or less. Please donate now! Full Stoplight Report America's Blood Centers is... FEATURED TODAY Support the Foundation ... purchase will be donated to the Foundation for America's Blood Centers! Simply Click Here! "We Are" This ...

  11. Hydrologic Engineering Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

  12. RSW Cell Centered Grids

    Data.gov (United States)

    National Aeronautics and Space Administration — New cell centered grids are generated to complement the node-centered ones uploaded. Six tarballs containing the coarse, medium, and fine mixed-element and pure...

  13. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Home / Safety Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon monoxide, also known as CO, is called the "Invisible ...

  14. BKG Data Center

    Science.gov (United States)

    Thorandt, Volkmar; Wojdziak, Reiner

    2013-01-01

    This report summarizes the activities and background information of the IVS Data Center for the year 2012. Included is information about functions, structure, technical equipment, and staff members of the BKG Data Center.

  15. ACTS data center

    Science.gov (United States)

    Syed, Ali; Vogel, Wolfhard J.

    1993-01-01

    Viewgraphs on ACTS Data Center status report are included. Topics covered include: ACTS Data Center Functions; data flow overview; PPD flow; RAW data flow; data compression; PPD distribution; RAW Data Archival; PPD Audit; and data analysis.

  16. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon monoxide, also known ... Install one and check its batteries regularly. View Information About CO Alarms Other CO Topics Safety Tips ...

  17. National Farm Medicine Center

    Science.gov (United States)

    ... Staff Agricultural Health and Safety Core Units Children's Center Cultivate Newsletter Journal of Agromedicine Milestones Auction of ... Farm Medicine, Rural Health & Safety National Farm Medicine Center Established in 1981 in response to occupational health ...

  18. Transplant Center Directory

    Science.gov (United States)

    ... mission. Learn more. My Account News Search Transplant Center Search Use the tools below to find a ... or enter your diagnosis to search for transplant centers. Select state(s) (optional) Enter diagnosis (optional) Please select ...

  19. NIST Diffusion Data Center

    Science.gov (United States)

    NIST Diffusion Data Center (Web, free access)   The NIST Diffusion Data Center is a collection of over 14,100 international papers, theses, and government reports on diffusion published before 1980.

  20. 'Motor control center obsolescence'

    International Nuclear Information System (INIS)

    A significant and growing problem within the global nuclear industry is the aging of motor control center (MCC) components. MCC's have a very important role in the safety and critical to generation requirements of a nuclear power plant. Although many OEM's MCC's such as ITE/Telemechanique, GE, Westinghouse, Cutler Hammer, Klockner Moeller, etc. have been used throughout the global nuclear industry, they all have one common aspect obsolescence. Obsolescence of various components within the MCC's such as molded case circuit breakers, starters, relays, heaters, contactors, etc. are impacting the reliability of the MCC to serve its intended function. The paper will discuss the options which the nuclear industry is faced with to increase the reliability of the MCC's while maintaining design control, qualification and meeting budget constraints. The options as listed below shall be discussed in detail with examples to enhance the readers understanding of the situation: 1) Component by component replacement: The hurdles associated with trying to find equivalent components to replace the obsolete components while still worki (mechanically and electrically) in the original cubicle will be presented. 2) Complete MCC cubicle with new internal components replacement: The process of supplying a replacement cubicle, with all new internal components and new door to replace the original cubicle will be discussed. The presentation will conclude with a comparison of the advantages and dis-advantages of the two methods to bring the MCC to an as new condition with the overall goal of increasing reliability. (author)

  1. Neutral Current $\

    CERN Document Server

    Chauhan, S; Singh, S K

    2011-01-01

    We calculate cross sections for the neutral current induced neutrino/antineutrino reaction from $^{208}Pb$ target and applied it to study Supernova neutrino event rates. The calculations are done in local density approximation taking into account Pauli blocking, Fermi motion effects and renormalization of weak transition strengths in the nuclear medium. The numerical results for the neutrino nucleus total cross sections have been averaged over the various Supernova neutrino/antineutrino fluxes available in literature.

  2. Center of buoyancy definition

    International Nuclear Information System (INIS)

    The center of buoyancy of an arbitrary shaped body is defined in analogy to the center of gravity. The definitions of the buoyant force and center of buoyancy in terms of integrals over the area of the body are converted to volume integrals and shown to have simple intuitive interpretations

  3. Data center cooling method

    Science.gov (United States)

    Chainer, Timothy J.; Dang, Hien P.; Parida, Pritish R.; Schultz, Mark D.; Sharma, Arun

    2015-08-11

    A method aspect for removing heat from a data center may use liquid coolant cooled without vapor compression refrigeration on a liquid cooled information technology equipment rack. The method may also include regulating liquid coolant flow to the data center through a range of liquid coolant flow values with a controller-apparatus based upon information technology equipment temperature threshold of the data center.

  4. Oklahoma Center for High Energy Physics (OCHEP)

    Energy Technology Data Exchange (ETDEWEB)

    Nandi, S; Strauss, M J; Snow, J; Rizatdinova, F; Abbott, B; Babu, K; Gutierrez, P; Kao, C; Khanov, A; Milton, K A; Neaman, H; H Severini, P Skubic

    2012-02-29

    The DOE EPSCoR implementation grant, with the support from the State of Oklahoma and from the three universities, Oklahoma State University, University of Oklahoma and Langston University, resulted in establishing of the Oklahoma Center for High Energy Physics (OCHEP) in 2004. Currently, OCHEP continues to flourish as a vibrant hub for research in experimental and theoretical particle physics and an educational center in the State of Oklahoma. All goals of the original proposal were successfully accomplished. These include foun- dation of a new experimental particle physics group at OSU, the establishment of a Tier 2 computing facility for the Large Hadron Collider (LHC) and Tevatron data analysis at OU and organization of a vital particle physics research center in Oklahoma based on resources of the three universities. OSU has hired two tenure-track faculty members with initial support from the grant funds. Now both positions are supported through OSU budget. This new HEP Experimental Group at OSU has established itself as a full member of the Fermilab D0 Collaboration and LHC ATLAS Experiment and has secured external funds from the DOE and the NSF. These funds currently support 2 graduate students, 1 postdoctoral fellow, and 1 part-time engineer. The grant initiated creation of a Tier 2 computing facility at OU as part of the Southwest Tier 2 facility, and a permanent Research Scientist was hired at OU to maintain and run the facility. Permanent support for this position has now been provided through the OU university budget. OCHEP represents a successful model of cooperation of several universities, providing the establishment of critical mass of manpower, computing and hardware resources. This led to increasing Oklahoma's impact in all areas of HEP, theory, experiment, and computation. The Center personnel are involved in cutting edge research in experimental, theoretical, and computational aspects of High Energy Physics with the research areas ranging

  5. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Training Building a Diverse Workforce Other Fellowships and Internships Program Contacts About Center for Cancer Training (CCT) ... Training (Extramural) Building a Diverse Workforce Other Fellowships & Internships Training Program Contacts News & Events Press Releases Resources ...

  6. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Research Leadership Director's Page Previous NCI Directors NCI Organization Advisory Boards Budget & Appropriations About the Annual Plan & ... Cancer Research Senior Leadership Director Previous Directors NCI Organization Divisions, Offices & Centers Advisory Boards & Groups Budget & Appropriations ...

  7. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Laboratory for Cancer Research Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Cancer Genomics Causes of ... Centers Frederick National Lab Partners & Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes ...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... to treatment Seeking Information About Your Prognosis Is a Personal Decision When you have cancer, you and ... how long she has to live. For Doctors, a Patient-Centered Approach View this video on YouTube. ...

  9. Supernova neutrino oscillations: what do we understand?

    OpenAIRE

    Dighe, Amol

    2009-01-01

    We summarize our current understanding of the neutrino flavor conversions inside a core collapse supernova, clarifying the important role played by the "collective effects" in determining flavor conversion probabilities. The potentially observable $\

  10. Understanding individual routing behaviour.

    Science.gov (United States)

    Lima, Antonio; Stanojevic, Rade; Papagiannaki, Dina; Rodriguez, Pablo; González, Marta C

    2016-03-01

    Knowing how individuals move between places is fundamental to advance our understanding of human mobility (González et al. 2008 Nature 453, 779-782. (doi:10.1038/nature06958)), improve our urban infrastructure (Prato 2009 J. Choice Model. 2, 65-100. (doi:10.1016/S1755-5345(13)70005-8)) and drive the development of transportation systems. Current route-choice models that are used in transportation planning are based on the widely accepted assumption that people follow the minimum cost path (Wardrop 1952 Proc. Inst. Civ. Eng. 1, 325-362. (doi:10.1680/ipeds.1952.11362)), despite little empirical support. Fine-grained location traces collected by smart devices give us today an unprecedented opportunity to learn how citizens organize their travel plans into a set of routes, and how similar behaviour patterns emerge among distinct individual choices. Here we study 92 419 anonymized GPS trajectories describing the movement of personal cars over an 18-month period. We group user trips by origin-destination and we find that most drivers use a small number of routes for their routine journeys, and tend to have a preferred route for frequent trips. In contrast to the cost minimization assumption, we also find that a significant fraction of drivers' routes are not optimal. We present a spatial probability distribution that bounds the route selection space within an ellipse, having the origin and the destination as focal points, characterized by high eccentricity independent of the scale. While individual routing choices are not captured by path optimization, their spatial bounds are similar, even for trips performed by distinct individuals and at various scales. These basic discoveries can inform realistic route-choice models that are not based on optimization, having an impact on several applications, such as infrastructure planning, routing recommendation systems and new mobility solutions. PMID:26962031

  11. Lupus nephritis: current update

    OpenAIRE

    Saxena, Ramesh; Mahajan, Tina; Mohan, Chandra

    2011-01-01

    Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some time in the course of their illness. Prompt recognition and treatment of renal disease is important, as early response to therapy is correlated with better outcome. The present review summarizes our current understanding of the pathogenic mechanisms underlying lupus nephritis and how th...

  12. Semantic Borders and Incomplete Understanding.

    Science.gov (United States)

    Silva-Filho, Waldomiro J; Dazzani, Maria Virgínia

    2016-03-01

    In this article, we explore a fundamental issue of Cultural Psychology, that is our "capacity to make meaning", by investigating a thesis from contemporary philosophical semantics, namely, that there is a decisive relationship between language and rationality. Many philosophers think that for a person to be described as a rational agent he must understand the semantic content and meaning of the words he uses to express his intentional mental states, e.g., his beliefs and thoughts. Our argument seeks to investigate the thesis developed by Tyler Burge, according to which our mastery or understanding of the semantic content of the terms which form our beliefs and thoughts is an "incomplete understanding". To do this, we discuss, on the one hand, the general lines of anti-individualism or semantic externalism and, on the other, criticisms of the Burgean notion of incomplete understanding - one radical and the other moderate. We defend our understanding that the content of our beliefs must be described in the light of the limits and natural contingencies of our cognitive capacities and the normative nature of our rationality. At heart, anti-individualism leads us to think about the fact that we are social creatures, living in contingent situations, with important, but limited, cognitive capacities, and that we receive the main, and most important, portion of our knowledge simply from what others tell us. Finally, we conclude that this discussion may contribute to the current debate about the notion of borders. PMID:26111737

  13. What do we mean by Human-Centered Design of Life-Critical Systems?

    Science.gov (United States)

    Boy, Guy A

    2012-01-01

    Human-centered design is not a new approach to design. Aerospace is a good example of a life-critical systems domain where participatory design was fully integrated, involving experimental test pilots and design engineers as well as many other actors of the aerospace engineering community. This paper provides six topics that are currently part of the requirements of the Ph.D. Program in Human-Centered Design of the Florida Institute of Technology (FIT.) This Human-Centered Design program offers principles, methods and tools that support human-centered sustainable products such as mission or process control environments, cockpits and hospital operating rooms. It supports education and training of design thinkers who are natural leaders, and understand complex relationships among technology, organizations and people. We all need to understand what we want to do with technology, how we should organize ourselves to a better life and finally find out whom we are and have become. Human-centered design is being developed for all these reasons and issues. PMID:22317415

  14. Understanding readers' understanding theory to practice

    CERN Document Server

    Tierney, Robert J; Mitchell, Judy Nichols

    2013-01-01

    This collection features papers addressing current issues in reading comprehension from cognitive and linguistic perspectives. Organized into three sections, the volume investigates text considerations and reader-text interactions. Each paper presents a substantial and comprehensive review of theory and research related to cognition and reading comprehension.

  15. Current ornithology

    CERN Document Server

    1983-01-01

    The appearance of the first volume of a projected series is the occasion for comment on scope, aims, and genesis of the work. The scope of Current Ornithology is all of the biology of birds. Ornithology, as a whole-organism science, is concerned with birds at every level of bi­ ological organization, from the molecular to the community, at least from the Jurassic to the present time, and over every scholarly discipline in which bird biology is done; to say this is merely to expand a dic­ tionary definition of "ornithology. " The aim of the work, to be realized over several volumes, is to present reviews or position statements con­ cerning the active fields of ornithological research. The reviews will be relatively short, and often will be done from the viewpoint of a readily­ identified group or school. Such a work could have come into being at any time within the past fifty years, but that Current Ornithology appears now is a result of events that are only seven to eight years old. One important event wa...

  16. Understanding quantum physics

    International Nuclear Information System (INIS)

    This thesis presents a bundle definition for 'scientific understanding' through which the empirically equivalent interpretations of quantum mechanics can be evaluated with respect to the understanding they generate. The definition of understanding is based on a sufficient and necessary criterion, as well as a bundle of conditions - where a theory can be called most understandable whenever it fulfills the highest number of bundle criteria. Thereby the definition of understanding is based on the one hand on the objective number of criteria a theory fulfills, as well as, on the other hand, on the individual's preference of bundle criteria. Applying the definition onto three interpretations of quantum mechanics, the interpretation of David Bohm appears as most understandable, followed by the interpretation of Tim Maudlin and the Kopenhagen interpretation. These three interpretations are discussed in length in my thesis. (orig.)

  17. High current gain transistor laser

    Science.gov (United States)

    Liang, Song; Qiao, Lijun; Zhu, Hongliang; Wang, Wei

    2016-06-01

    A transistor laser (TL), having the structure of a transistor with multi-quantum wells near its base region, bridges the functionality gap between lasers and transistors. However, light emission is produced at the expense of current gain for all the TLs reported up to now, leading to a very low current gain. We propose a novel design of TLs, which have an n-doped InP layer inserted in the emitter ridge. Numerical studies show that a current flow aperture for only holes can be formed in the center of the emitter ridge. As a result, the common emitter current gain can be as large as 143.3, which is over 15 times larger than that of a TL without the aperture. Besides, the effects of nonradiative recombination defects can be reduced greatly because the flow of holes is confined in the center region of the emitter ridge.

  18. Current profile control for high bootstrap current operation in ITER

    International Nuclear Information System (INIS)

    For the achievement of steady-state fusion power plant, non-inductively current-driven plasma operation should be maintained in tokamak fusion reactors. Total non-inductive current is a summation of bootstrap current proportional to the plasma pressure gradient and externally driven non-inductive current such as neutral beam driven current. Especially in order to establish a commercial reactor, it is necessary to reduce the amount of external current-drive power and to maintain the majority of the plasma current with bootstrap current. Burning plasma has high autonomy, so the change in current density profile including changes in particle and heat transports should be checked. In this study time-evolution analysis of the current density profile for burning plasmas in the ITER machine has been conducted by using 2.0-dimensional equilibrium, 1.5-dimensional-transport code (TOTAL code). Here current-diffusive ballooning mode model was adopted as a heat transport model. It is concluded that external current-drive is required both in the center and near the periphery of the plasma in order to maintain steady-state profiles of temperature and density with high bootstrap current fraction. (author)

  19. The NLM current catalog.

    Science.gov (United States)

    Wiggins, E V

    1969-01-01

    When the National Library of Medicine acquired a computer to augment its publication program, the intent was to present in one medium an index to journal articles and a catalog of books and new serial titles. The computer programs designed for indexing were unsatisfactory for cataloging, however; so two publications were issued, the Index Medicus and the NLM Current Catalog. The Current Catalog features separate name and subject sections, added volumes, and technical reports. The Express Cataloging Service was one of the first attempts to increase the speed and coverage of the Catalog. Shared cataloging with the Library of Congress, the Countway Library at Harvard, and the Upstate Medical Library in Syracuse, New York, have also contributed to the efforts toward improving this library service. An additional shared cataloging program, this time with the National Medical Audiovisual Center, is expected to be implemented shortly. PMID:5782262

  20. E-Center: A Collaborative Platform for Wide Area Network Users

    Science.gov (United States)

    Grigoriev, M.; DeMar, P.; Tierney, B.; Lake, A.; Metzger, J.; Frey, M.; Calyam, P.

    2012-12-01

    The E-Center is a social collaborative web-based platform for assisting network users in understanding network conditions across network paths of interest to them. It is designed to give a user the necessary tools to isolate, identify, and resolve network performance-related problems. E-Center provides network path information on a link-by-link level, as well as from an end-to-end perspective. In addition to providing current and recent network path data, E-Center is intended to provide a social media environment for them to share issues, ideas, concerns, and problems. The product has a modular design that accommodates integration of other network services that make use of the same network path and performance data.

  1. E-Center: A Collaborative Platform for Wide Area Network Users

    International Nuclear Information System (INIS)

    The E-Center is a social collaborative web-based platform for assisting network users in understanding network conditions across network paths of interest to them. It is designed to give a user the necessary tools to isolate, identify, and resolve network performance-related problems. E-Center provides network path information on a link-by-link level, as well as from an end-to-end perspective. In addition to providing current and recent network path data, E-Center is intended to provide a social media environment for them to share issues, ideas, concerns, and problems. The product has a modular design that accommodates integration of other network services that make use of the same network path and performance data.

  2. Memorizing versus Understanding

    Science.gov (United States)

    Suessmuth, Patrick

    1975-01-01

    Research is reported regarding lesson formats emphasizing memory versus understanding learning processes. Conclusions state that the most efficient teaching method is determined by the subject being taught. (LH)

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... our information on Coping With Cancer helpful. Understanding Statistics About Survival Doctors estimate prognosis by using statistics that researchers have collected over many years about ...

  4. Transcutaneous Spinal Direct Current Stimulation

    OpenAIRE

    Cogiamanian, Filippo; Ardolino, Gianluca; Vergari, Maurizio; Ferrucci, Roberta; Ciocca, Matteo; Scelzo, Emma; Barbieri, Sergio; Priori, Alberto

    2012-01-01

    In the past 10 years renewed interest has centered on non-invasive transcutaneous weak direct currents applied over the scalp to modulate cortical excitability (“brain polarization” or transcranial direct current stimulation, tDCS). Extensive literature shows that tDCS induces marked changes in cortical excitability that outlast stimulation. Aiming at developing a new, non-invasive, approach to spinal cord neuromodulation we assessed the after-effects of thoracic transcutaneous spinal DC stim...

  5. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Media Media Contacts Multicultural Media Outreach Program Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents ... 2011 Media Resources Media Contacts Multicultural Media Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents ...

  6. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Outreach Program Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog Research Findings Drug Approvals ... Multicultural Media Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog About NCI NCI Overview ...

  7. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Meetings Cancer Currents Blog About NCI NCI Overview History Contributing to Cancer Research Leadership Director's Page Previous ... Information Legislative Activities Hearings & Testimonies Current Congress Legislative History Committees of Interest Legislative Resources Recent Public Laws ...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Contacts Multicultural Media Outreach Program Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog Research ... Resources Media Contacts Multicultural Media Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog About ...

  9. IDEA Clean Energy Application Center

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, Robert

    2013-09-30

    The DOE Clean Energy Application Centers were launched with a goal of focusing on important aspects of our nation’s energy supply including Efficiency, Reliability and Resiliency. Clean Energy solutions based on Combined Heat & Power (CHP), District Energy and Waste Heat Recovery are at the core of ensuring a reliable and efficient energy infrastructure for campuses, communities, and industry and public enterprises across the country. IDEA members which include colleges and universities, hospitals, airports, downtown utilities as well as manufacturers, suppliers and service providers have long-standing expertise in the planning, design, construction and operations of Clean Energy systems. They represent an established base of successful projects and systems at scale and serve important and critical energy loads. They also offer experience, lessons learned and best practices which are of immense value to the sustained growth of the Clean Energy sector. IDEA has been able to leverage the funds from the project award to raise the visibility, improve the understanding and increase deployment CHP, District Energy and Waste Heat Recovery solutions across the regions of our nation, in collaboration with the regional CEAC’s. On August 30, 2012, President Obama signed an Executive Order to accelerate investments in industrial energy efficiency (EE), including CHP and set a national goal of 40 GW of new CHP installation over the next decade IDEA is pleased to have been able to support this Executive Order in a variety of ways including raising awareness of the goal through educational workshops and Conferences and recognizing the installation of large scale CHP and district energy systems A supporting key area of collaboration has involved IDEA providing technical assistance on District Energy/CHP project screenings and feasibility to the CEAC’s for multi building, multi-use projects. The award was instrumental in the development of a first-order screening

  10. Genomics:GTL Bioenergy Research Centers White Paper

    Energy Technology Data Exchange (ETDEWEB)

    Mansfield, Betty Kay [ORNL; Alton, Anita Jean [ORNL; Andrews, Shirley H [ORNL; Bownas, Jennifer Lynn [ORNL; Casey, Denise [ORNL; Martin, Sheryl A [ORNL; Mills, Marissa [ORNL; Nylander, Kim [ORNL; Wyrick, Judy M [ORNL; Drell, Dr. Daniel [Office of Science, Department of Energy; Weatherwax, Sharlene [U.S. Department of Energy; Carruthers, Julie [U.S. Department of Energy

    2006-08-01

    capabilities, but it is only a first step. Other advances include the growing number of high-throughput techniques for protein production and characterization; a range of new instrumentation for observing proteins and other cell constituents; the rapid growth of commercially available reagents for protein production; a new generation of high-intensity light sources that provide precision imaging on the nanoscale and allow observation of molecular interactions in ultrafast time intervals; major advances in computational capability; and the continually increasing numbers of these instruments and technologies within the national laboratory infrastructure, at universities, and in private industry. All these developments expand our ability to elucidate mechanisms present in living cells, but much more remains to be done. The Centers are designed to accomplish GTL program objectives more rapidly, more effectively, and at reduced cost by concentrating appropriate technologies and scientific expertise, from genome sequence to an integrated systems understanding of the pathways and internal structures of microbes and plants most relevant to developing bioenergy compounds. The Centers will seek to understand the principles underlying the structural and functional design of selected microbial, plant, and molecular systems. This will be accomplished by building technological pathways linking the genome-determined components in an organism with bioenergy-relevant cellular systems that can be characterized sufficiently to generate realistic options for biofuel development. In addition, especially in addressing what are believed to be nearer-term approaches to renewable energy (e.g., producing cellulosic ethanol cost-effectively and energy-efficiently), the Center research team must understand in depth the current industrial-level roadblocks and bottlenecks (see section, GTL's Vision for Biological Energy Alternatives, below). For the Centers, and indeed the entire BER effort, to be

  11. Inexpensive Eddy-Current Standard

    Science.gov (United States)

    Berry, Robert F., Jr.

    1985-01-01

    Radial crack replicas serve as evaluation standards. Technique entails intimately joining two pieces of appropriate aluminum alloy stock and centering drilled hole through and along interface. Bore surface of hole presents two vertical stock interface lines 180 degrees apart. These lines serve as radial crack defect replicas during eddy-current technique setup and verification.

  12. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Questions to Ask about Your Diagnosis Research Understanding Cancer Prognosis Oncologist Anthony L. Back, M.D., a ... for provider care teams (PDF-210KB). Understanding Your Cancer Prognosis Video View this video on YouTube. Three ...

  13. Parrot "Understands" Zero

    Science.gov (United States)

    Journal of College Science Teaching, 2005

    2005-01-01

    The walnut sized brain of the African grey parrot may actually be capable of comprehending abstract mathematical concepts. The bird seems to understand a numerical concept akin to zero--an abstract notion that humans don't typically understand until they are three or four years old. Alex, the 28-year-old parrot who lives in a Brandeis University…

  14. Understanding Food Labels

    Science.gov (United States)

    ... girls Eating healthy at restaurants Special food issues Vegetarian eating Eating for strong bones Quiz: Food Facts Links to more information girlshealth glossary girlshealth.gov home http://www.girlshealth.gov/ Home Nutrition Healthy eating for girls Understanding food labels Understanding ...

  15. Natural Language Understanding.

    Science.gov (United States)

    Waldrop, M. Mitchell

    1984-01-01

    Discusses several areas of artificial intelligence and research in this area, focusing on natural language understanding. Indicates that language is more than words, that "meaning" depends on context, and that "understanding" requires a vast body of knowledge about the world. (JN)

  16. Understanding cancer onset

    DEFF Research Database (Denmark)

    Veldhuis, Djuke

    2015-01-01

    Researchers in Malaysia analysed the genomes of people with a rare genetic disorder to better understand people’s predisposition to cancer across generations.......Researchers in Malaysia analysed the genomes of people with a rare genetic disorder to better understand people’s predisposition to cancer across generations....

  17. Approaches to understand culture

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard; Rauner, Felix

    1996-01-01

    Different approaches to understand the concept ofculture are presented and evaluated. The author'sconcept of culture is defined. Different aspectsof the concept are discussed.......Different approaches to understand the concept ofculture are presented and evaluated. The author'sconcept of culture is defined. Different aspectsof the concept are discussed....

  18. Narrativity and enaction: the social nature of literary narrative understanding.

    Science.gov (United States)

    Popova, Yanna B

    2014-01-01

    This paper proposes an understanding of literary narrative as a form of social cognition and situates the study of such narratives in relation to the new comprehensive approach to human cognition, enaction. The particular form of enactive cognition that narrative understanding is proposed to depend on is that of participatory sense-making, as developed in the work of Di Paolo and De Jaegher. Currently there is no consensus as to what makes a good literary narrative, how it is understood, and why it plays such an irreplaceable role in human experience. The proposal thus identifies a gap in the existing research on narrative by describing narrative as a form of intersubjective process of sense-making between two agents, a teller and a reader. It argues that making sense of narrative literature is an interactional process of co-constructing a story-world with a narrator. Such an understanding of narrative makes a decisive break with both text-centered approaches that have dominated both structuralist and early cognitivist study of narrative, as well as pragmatic communicative ones that view narrative as a form of linguistic implicature. The interactive experience that narrative affords and necessitates at the same time, I argue, serves to highlight the active yet cooperative and communal nature of human sociality, expressed in the many forms than human beings interact in, including literary ones. PMID:25202286

  19. Relativistic Guiding Center Equations

    Energy Technology Data Exchange (ETDEWEB)

    White, R. B. [PPPL; Gobbin, M. [Euratom-ENEA Association

    2014-10-01

    In toroidal fusion devices it is relatively easy that electrons achieve relativistic velocities, so to simulate runaway electrons and other high energy phenomena a nonrelativistic guiding center formalism is not sufficient. Relativistic guiding center equations including flute mode time dependent field perturbations are derived. The same variables as used in a previous nonrelativistic guiding center code are adopted, so that a straightforward modifications of those equations can produce a relativistic version.

  20. Neutral currents

    International Nuclear Information System (INIS)

    A short survey of the new experimental data on weak neutral currents is given, followed by a comparison with modern theoretical models. Cross sections of the anti νsub(e)e → anti νsub(e)e, anti νsub(μ)e→ νsub(μ)e, νp → νp and anti νp → anti νp elastic scattering as well as inclusive cross sections of the ν+N → ν+X and anti ν+N → anti ν+X deep inelastic scattering are presented. On the basis of the comparison the Weinberg-Salam model is concluded to be in a good agreement with the shape of the cross sections. Six-quark vector models appear to be ruled out. The five-quark model due to Achiman, Koller and Walsh and two versions of the Gursey-Sikivie model satisfactorily account for the observed data in shape and in magnitude

  1. Airline Operation Center Workstation

    Data.gov (United States)

    Department of Transportation — The Airline Operation Center Workstation (AOC Workstation) represents equipment available to users of the National Airspace system, outside of the FAA, that enables...

  2. Chemical Security Analysis Center

    Data.gov (United States)

    Federal Laboratory Consortium — In 2006, by Presidential Directive, DHS established the Chemical Security Analysis Center (CSAC) to identify and assess chemical threats and vulnerabilities in the...

  3. Small Business Development Center

    Data.gov (United States)

    Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...

  4. Electron Microscopy Center (EMC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Electron Microscopy Center (EMC) at Argonne National Laboratory develops and maintains unique capabilities for electron beam characterization and applies those...

  5. Center for Deployment Psychology

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Deployment Psychology was developed to promote the education of psychologists and other behavioral health specialists about issues pertaining to the...

  6. Data Center at NICT

    Science.gov (United States)

    Ichikawa, Ryuichi; Sekido, Mamoru

    2013-01-01

    The Data Center at the National Institute of Information and Communications Technology (NICT) archives and releases the databases and analysis results processed at the Correlator and the Analysis Center at NICT. Regular VLBI sessions of the Key Stone Project VLBI Network were the primary objective of the Data Center. These regular sessions continued until the end of November 2001. In addition to the Key Stone Project VLBI sessions, NICT has been conducting geodetic VLBI sessions for various purposes, and these data are also archived and released by the Data Center.

  7. Test Control Center (TCC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Test Control Center (TCC) provides a consolidated facility for planning, coordinating, controlling, monitoring, and analyzing distributed test events. ,The TCC...

  8. Environmental Modeling Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  9. The concept of externality: Implications for TVA Environmental Research Center

    Energy Technology Data Exchange (ETDEWEB)

    Foster, T.H.

    1994-06-01

    Pollution of the environment is a result of the economic activities of production and consumption. And although the market system is touted as the superior method of organizing and operating an economic system, society frequently is dissatisfied with some of the side effects. In these cases of market failure, a cry for intervention often is raised to obtain more socially-desirable solutions. Environmental pollution is one symptom of market failure. If the TVA Environmental Research Center is to focus on defining solutions to environmental problems and designing policy options for implementing such solutions, its efforts should benefit from an understanding of why the market fails and how it may be adjusted to produce more socially-desirable results. The purposes of this report are to: (1) promote an appreciation for and understanding of the concept of externality; (2) demonstrate the utility of the concept in the design and packaging of policy and technology for improved environmental performance; (3) provide a brief summary of the externality valuation issue currently being debated by the electric power industry; and (4) identify environmental research and development agenda opportunities or strategic considerations suggested for the Center by this review.

  10. Fuzzy Logic Reliability Centered Maintenance

    Directory of Open Access Journals (Sweden)

    Felecia .

    2014-01-01

    Full Text Available Reliability Centered Maintenence (RCM is a systematic maintenence strategy based on system reliability. Application of RCM process will not always come out with a binary output of “yes” and “no”. Most of the time they are not supported with available detail information to calculate system reliability. The fuzzy logic method attempts to eliminate the uncertainty by providing “truth” in different degrees.Data and responses from maintenance department will be processed using the two methods (reliability centered maintenance and fuzzy logic to design maintenance strategy for the company. The results of the fuzzy logic RCM application are maintenance strategy which fit with current and future condition.

  11. Understanding Animal Welfare

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Awareness increases in China over the issue of protecting pets HAO Xiaomao is a truck driver,shipping whatever his employers ask him to from his hometown of Jiaozuo City in central China’s Henan Province to northeast China.But one of his recent hauls put him in the center of a nationwide controversy.

  12. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... tell her how long she has to live. For Doctors, a Patient-Centered Approach View this video on YouTube. Anthony L. Back, M.D., coaches other oncologists about how to discuss prognosis with their patients. Good communication, he says, is part of providing good care. ...

  13. MDCC: Multi-Data Center Consistency

    CERN Document Server

    Kraska, Tim; Franklin, Michael J; Madden, Samuel

    2012-01-01

    Replicating data across multiple data centers not only allows moving the data closer to the user and, thus, reduces latency for applications, but also increases the availability in the event of a data center failure. Therefore, it is not surprising that companies like Google, Yahoo, and Netflix already replicate user data across geographically different regions. However, replication across data centers is expensive. Inter-data center network delays are in the hundreds of milliseconds and vary significantly. Synchronous wide-area replication is therefore considered to be unfeasible with strong consistency and current solutions either settle for asynchronous replication which implies the risk of losing data in the event of failures, restrict consistency to small partitions, or give up consistency entirely. With MDCC (Multi-Data Center Consistency), we describe the first optimistic commit protocol, that does not require a master or partitioning, and is strongly consistent at a cost similar to eventually consiste...

  14. Computing machinery and understanding.

    Science.gov (United States)

    Ramscar, Michael

    2010-08-01

    How are natural symbol systems best understood? Traditional "symbolic" approaches seek to understand cognition by analogy to highly structured, prescriptive computer programs. Here, we describe some problems the traditional computational metaphor inevitably leads to, and a very different approach to computation (Ramscar, Yarlett, Dye, Denny, & Thorpe, 2010; Turing, 1950) that allows these problems to be avoided. The way we conceive of natural symbol systems depends to a large degree on the computational metaphors we use to understand them, and machine learning suggests an understanding of symbolic thought that is very different to traditional views (Hummel, 2010). The empirical question then is: Which metaphor is best? PMID:21564241

  15. Funding Opportunity: Genomic Data Centers

    Science.gov (United States)

    Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

  16. HRSA: Find a Health Center

    Science.gov (United States)

    ... Please, try later. Close × Note To HRSA Health Centers: HRSA Health Center Grantees and Look-Alikes, please ... to save your changes. Close About HRSA Health Centers HRSA Health Centers care for you, even if ...

  17. Establishing a national research center on day care

    DEFF Research Database (Denmark)

    Ellegaard, Tomas

    The paper presents and discusses the current formation of a national research center on ECEC. The center is currently being established. It is partly funded by the Danish union of early childhood and youth educators. It is based on cooperation between a number of Danish universities and this nati...

  18. Data center networks and network architecture

    Science.gov (United States)

    Esaki, Hiroshi

    2014-02-01

    This paper discusses and proposes the architectural framework, which is for data center networks. The data center networks require new technical challenges, and it would be good opportunity to change the functions, which are not need in current and future networks. Based on the observation and consideration on data center networks, this paper proposes; (i) Broadcast-free layer 2 network (i.e., emulation of broadcast at the end-node), (ii) Full-mesh point-to-point pipes, and (iii) IRIDES (Invitation Routing aDvertisement for path Engineering System).

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... How to best take care of yourself and manage treatment side effects How to deal with financial ... for patients (PDF-210KB) and for provider care teams (PDF-210KB). Understanding Your Cancer Prognosis Video View ...

  20. Understanding Infertility - The Basics

    Medline Plus

    Full Text Available ... Smoking Cessation Links to Professional Societies and Organizations Home › Understanding Infertility - The Basics A series of patient ... Find a Health Care Provider Back to Top Home | About Us | Reproductive Health Topics | News & Publications | Resources ...

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... you have cancer, you and your loved ones face many unknowns. Understanding your cancer and knowing what ... make decisions. Some of the decisions you may face include: Which treatment is best for you If ...

  2. Understanding Sexual Violence

    Science.gov (United States)

    Understanding Sexual Violence Fact Sheet 2014 Sexual violence refers to any sexual activity where consent is not obtained or freely given. Anyone can experience or perpetrate sexual violence. Most victims of ...

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview ... Statistics Understanding Cancer What Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening ...

  4. Understanding Infertility - The Basics

    Medline Plus

    Full Text Available ... and Smoking Cessation Links to Professional Societies and Organizations Home › Understanding Infertility - The Basics A series of ... Site Terms & Conditions of Use | Web Design and Development by The Berndt Group

  5. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Understanding Cancer What ... Cancer & Caregivers Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Cancer Types Adolescents ...

  6. Understanding health insurance plans

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000879.htm Understanding health insurance plans To use the sharing features on this ... for you and your family. Types of Health Insurance Plans Depending on how you get your health ...

  7. Understanding the New Economy.

    Science.gov (United States)

    Morrell, Louis R.

    2001-01-01

    Asserts that while the Nasdaq bubble did burst, the new economy is real and that failure to understand the rules of the digital economy can lead to substandard investment portfolio performance. Offers guidelines for higher education institutional investors. (EV)

  8. Understand Quarantine and Isolation

    Science.gov (United States)

    ... Social Media What CDC is Doing Blog: Public Health Matters What's New Preparation & Planning Emergency Preparedness and Response Understand Quarantine and Isolation Recommend on Facebook Tweet Share Compartir Isolation and quarantine help protect the public by ...

  9. Understanding Vector Fields.

    Science.gov (United States)

    Curjel, C. R.

    1990-01-01

    Presented are activities that help students understand the idea of a vector field. Included are definitions, flow lines, tangential and normal components along curves, flux and work, field conservation, and differential equations. (KR)

  10. Understanding Infertility - The Basics

    Medline Plus

    Full Text Available ... discusses various methods of coping with infertility. Infertility Treatments 450 x 274 | Running Time: 4 min 42 ... American Society for Reproductive Medicine discusses the various treatments for infertility. Understanding Fertility 450 x 274 | Running ...

  11. Understanding Child Traumatic Stress

    Science.gov (United States)

    ... Public Awareness Sustainability Policy Issues Understanding Child Traumatic Stress Page Contents: Responding to Danger When Danger Turns ... malevolence, and human accountability. Back to Top Posttraumatic Stress Responses For reasons that are basic to survival, ...

  12. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Understanding Cancer ... Cancer Advanced Cancer & Caregivers Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Cancer Types ...

  13. Speech recognition and understanding

    Energy Technology Data Exchange (ETDEWEB)

    Vintsyuk, T.K.

    1983-05-01

    This article discusses the automatic processing of speech signals with the aim of finding a sequence of works (speech recognition) or a concept (speech understanding) being transmitted by the speech signal. The goal of the research is to develop an automatic typewriter that will automatically edit and type text under voice control. A dynamic programming method is proposed in which all possible class signals are stored, after which the presented signal is compared to all the stored signals during the recognition phase. Topics considered include element-by-element recognition of words of speech, learning speech recognition, phoneme-by-phoneme speech recognition, the recognition of connected speech, understanding connected speech, and prospects for designing speech recognition and understanding systems. An application of the composition dynamic programming method for the solution of basic problems in the recognition and understanding of speech is presented.

  14. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... disease will go for you is called prognosis. It can be hard to understand what prognosis means ... prognosis include: The type of cancer and where it is in your body The stage of the ...

  15. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... side effects from the cancer treatments you received. Video Series This video series offers the perspectives of ... care teams (PDF-210KB). Understanding Your Cancer Prognosis Video View this video on YouTube. Three cancer patients ...

  16. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Budget Annual Plan & Budget Proposal Congressional Justification NCI Budget Fact Book Legislative Activities Hearings & Testimonies Current Congress Legislative History Committees of ...

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Budget Fact Book Careers at NCI Visitor Information Legislative Activities Hearings & Testimonies Current Congress Legislative History Committees of Interest Legislative Resources Recent Public ...

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Proposal NCI Congressional Justification NCI Budget Fact Book Careers at NCI Visitor Information Legislative Activities Hearings & Testimonies Current Congress Legislative History Committees of ...

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training at NCI ... Hearings & Testimonies Current Congress Legislative History ...

  20. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Consumers Businesses Contact CPSC Website Design Feedback Consumers: Español Businesses: Español , 中文 , Tiếng Việt Connect with Us : Twitter YouTube ... Safely Home / Safety Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon ...

  1. About the ADEAR Center

    Science.gov (United States)

    ... and news updates How to Contact the ADEAR Center Call toll-free at: 1-800-438-4380 (8: ... To give you the best possible service, ADEAR Center staff abide by the following customer service standards: We will answer your telephone calls promptly between 8:30 a.m. and 5: ...

  2. From Periphery To Center

    DEFF Research Database (Denmark)

    Carré, David

    2014-01-01

    notions of Center/Periphery. As Hermans (2001) proposed, center and periphery are not fixed ‘I-positions’ of the self; in this vein, these notions are explored as relevant theoretical tools for addressing the developmental trajectories involved in the construction of scientific identities. In sum, the...

  3. Simple Machine Science Centers

    Science.gov (United States)

    Chessin, Debby

    2007-01-01

    Science centers can engage students; accommodate different learning styles and individual interests; help students become independent and confident learners; and encourage social skills among students. In this article, the author worked with third-grade students as they completed activities at learning centers during a week-long unit on simple…

  4. Technology Information Center

    International Nuclear Information System (INIS)

    A Transportation Technology Center (TTC) has been established at Sandia to address the transportation of nuclear waste and spent fuel. The Technology Information Center (TIC) acts as TTC's clearing house for nuclear material transportation information. TIC's activities are divided into three activities: public information, policy information, and technical information. Some of the uses of TIC's activities are briefly outlined

  5. Call Center Capacity Planning

    DEFF Research Database (Denmark)

    Nielsen, Thomas Bang

    The main topics of the thesis are theoretical and applied queueing theory within a call center setting. Call centers have in recent years become the main means of communication between customers and companies, and between citizens and public institutions. The extensively computerized infrastructure...

  6. Understanding Conflict?...Maybe!

    OpenAIRE

    Anthony P. Johnson

    2008-01-01

    The premise of this paper is the study in the field of conflict andconflict resolution and that conflict and conflict resolution are usefulareas of focus in order to better understand human behavior. Additionally,I will present data that will highlight the notion that conflict is not in itselfa bad thing and that conflict has the capability to be utilized as a vehiclefor understanding the many contradictions that are necessarily present inour efforts to be social beings.

  7. Understanding Conflict?...Maybe!

    Directory of Open Access Journals (Sweden)

    Anthony P. Johnson

    2008-12-01

    Full Text Available The premise of this paper is the study in the field of conflict andconflict resolution and that conflict and conflict resolution are usefulareas of focus in order to better understand human behavior. Additionally,I will present data that will highlight the notion that conflict is not in itselfa bad thing and that conflict has the capability to be utilized as a vehiclefor understanding the many contradictions that are necessarily present inour efforts to be social beings.

  8. Optical OFDM-based Data Center Networks

    Directory of Open Access Journals (Sweden)

    Christoforos Kachris

    2013-07-01

    Full Text Available Cloud computing and web emerging application has created the need for more powerful data centers with high performance interconnection networks.Current data center networks,based on electronic packet switches,will not be able to satisfy the required communication bandwidth of emerging applications without consuming excessive power.Optical interconnercts have gained attention recently as a promising solution offering high throughput,low latency and reduced energy cosumption compared to current networks based in commidity switches.This paper presents a novel architecture for data center networks based on optical OFDM using Wavelength Selective Swithces(WSS. The OFDM-based solution provides high throughput,reduced latency and fine grain bandwidth allocation. A heuristic algorithm for the bandwidth allocation is presented and evaluated in terms of utilization. The power analysis shows that the proposed scheme is almost 60% more energy efficient compared to the current networks based on eommodity switches.

  9. A Meaning-Centered Therapy for Addictions

    Science.gov (United States)

    Thompson, Geoff

    2012-01-01

    This article describes a treatment for addictions, based on the idea that addiction is a response to living a life that has little personal meaning. First, it presents the theory of Meaning-Centered Therapy (MCT) as developed by Paul Wong, particularly the need to understand intoxication from the addict's perspective. Next, it presents the…

  10. Center for Applied Linguistics, Washington DC, USA

    Science.gov (United States)

    Sugarman, Julie; Fee, Molly; Donovan, Anne

    2015-01-01

    The Center for Applied Linguistics (CAL) is a private, nonprofit organization with over 50 years' experience in the application of research on language and culture to educational and societal concerns. CAL carries out its mission to improve communication through better understanding of language and culture by engaging in a variety of projects in…

  11. Relative Lyapunov Center Bifurcations

    DEFF Research Database (Denmark)

    Wulff, Claudia; Schilder, Frank

    2014-01-01

    Relative equilibria (REs) and relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur, for example, in celestial mechanics, molecular dynamics, and rigid body motion. REs are equilibria, and RPOs are periodic orbits of the symmetry reduced system. Relative Lyapunov...... center bifurcations are bifurcations of RPOs from REs corresponding to Lyapunov center bifurcations of the symmetry reduced dynamics. In this paper we first prove a relative Lyapunov center theorem by combining recent results on the persistence of RPOs in Hamiltonian systems with a symmetric Lyapunov...... center theorem of Montaldi, Roberts, and Stewart. We then develop numerical methods for the detection of relative Lyapunov center bifurcations along branches of RPOs and for their computation. We apply our methods to Lagrangian REs of the N-body problem....

  12. Planning for regional centers

    International Nuclear Information System (INIS)

    In conclusion, the successful development and implementation of a multinational nuclear fuel cycle project will require that it be economically viable and satisfy the overlying interests and concerns of the participants. To assure success, it is absolutely essential that the initial planning, development of project criteria, and implementation be based on an authoritative understanding of the real needs of and benefits to all potential participants. The organizational structure for such a project must contain appropriate checks and balances that are sufficient to protect investors, owners, and consumers. Because of its special nature, these checks and balances must also provide for satisfying other important interests, such as an operating organization that addresses nonproliferation concerns and nuclear safeguards. The next logical step in the evolution of regional nuclear complexes is to determine whether such an approach is, indeed, economically viable, financially attractive, and operationally practical. Those who have succeeded in structuring nonnuclear, energy-related complexes currently operating throughout the world today should be looked to for developing the feasibility study of this concept in the nuclear field

  13. buffer Layer Growth, the Thickness Dependence of Jc in Coated Conductors, Local Identification of Current Limiting Mechanisms and Participation in the Wire Development Group

    Energy Technology Data Exchange (ETDEWEB)

    Larbalestier, David; Hellstron, Eric; Abraimov, Dmytro

    2011-12-17

    The primary thrusts of our work were to provide critical understanding of how best to enhance the current-carrying capacity of coated conductors. These include the deconstruction of Jc as a function of fim thickness, the growth of in situ films incorporating strong pinning centers and the use of a suite of position-sensitive tools that enable location and analysis of key areas where current-limiting occurs.

  14. Internet gaming addiction: current perspectives

    OpenAIRE

    Kuss DJ

    2013-01-01

    Daria J KussPsychology Research and Behavior Management, Birmingham City University, Birmingham, UKAbstract: In the 2000s, online games became popular, while studies of Internet gaming addiction emerged, outlining the negative consequences of excessive gaming, its prevalence, and associated risk factors. The establishment of specialized treatment centers in South-East Asia, the US, and Europe reflects the growing need for professional help. It is argued that only by understanding the appeal o...

  15. EERC Center for Biomass Utilization 2005

    Energy Technology Data Exchange (ETDEWEB)

    Zygarlicke, C J; Schmidt, D D; Olson, E S; Leroux, K M; Wocken, C A; Aulich, T A; WIlliams, K D

    2008-07-28

    Biomass utilization is one solution to our nation’s addiction to oil and fossil fuels. What is needed now is applied fundamental research that will cause economic technology development for the utilization of the diverse biomass resources in the United States. This Energy & Environmental Research Center (EERC) applied fundamental research project contributes to the development of economical biomass utilization for energy, transportation fuels, and marketable chemicals using biorefinery methods that include thermochemical and fermentation processes. The fundamental and basic applied research supports the broad scientific objectives of the U.S. Department of Energy (DOE) Biomass Program, especially in the area of developing alternative renewable biofuels, sustainable bioenergy, technologies that reduce greenhouse gas emissions, and environmental remediation. Its deliverables include 1) identifying and understanding environmental consequences of energy production from biomass, including the impacts on greenhouse gas production, carbon emission abatement, and utilization of waste biomass residues and 2) developing biology-based solutions that address DOE and national needs related to waste cleanup, hydrogen production from renewable biomass, biological and chemical processes for energy and fuel production, and environmental stewardship. This project serves the public purpose of encouraging good environmental stewardship by developing biomass-refining technologies that can dramatically increase domestic energy production to counter current trends of rising dependence upon petroleum imports. Decreasing the nation’s reliance on foreign oil and energy will enhance national security, the economy of rural communities, and future competitiveness. Although renewable energy has many forms, such as wind and solar, biomass is the only renewable energy source that can be governed through agricultural methods and that has an energy density that can realistically compete with

  16. Probing luminescence centers in Na rich feldspar

    DEFF Research Database (Denmark)

    Prasad, Amit Kumar; Lapp, Torben; Kook, Myung Ho;

    2016-01-01

    In contrast to the detailed investigations on the dosimetric electron trap in feldspar only little has been done to understand the luminescence centers. We use a comparison of multiple spectroscopic techniques, site selective photoluminescence spectroscopy and time resolved measurements to further...... our understanding of the luminescence mechanisms and recombination sites, in a sample of Na rich plagioclase feldspar (oligoclase). Both the UV and violet–blue emissions show resonant excitations arising from a distribution of energy levels. We propose, contrary to the general understanding...

  17. Understanding the system in risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Craft, R.; Vandewart, R.; Wyss, G.; Funkhouser, D.

    1998-02-01

    In the assessment of a system, understanding the system is central. Even so, most of the current literature takes a narrow view of understanding, making only the catalog of system ``assets`` explicit, while maintaining the balance of the analyst`s understanding inside the analyst`s head. This can lead to problems with non-repeatability and incompleteness of assessment results. This paper introduces the notion of using explicit system models to document the analyst`s understanding of the system and shows that, from these models, standard assessment products, such as fault trees and event trees, can be automatically derived. This paper also presents five ``views`` of a system that can be used to document the analyst`s understanding of the system. These views go well beyond the standard instruction to identify the system`s assets to show that a much richer understanding of the system can be required for effective assessment.

  18. Understanding the early cycling evolution behaviors for phase change memory application

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yuchan, E-mail: yuchanwang87@gmail.com; Chen, Yifeng, E-mail: yfchen@mail.sim.ac.cn; Cai, Daolin; Cheng, Yan; Chen, Xiaogang; Wang, Yueqing; Xia, Mengjiao; Zhou, Mi; Li, Gezi; Zhang, Yiyun; Gao, Dan; Song, Zhitang [State Key Laboratory of Functional Materials for Informatics and Nanotechnology Laboratory, Shanghai Institute of Micro-system and Information Technology, Chinese Academy of Sciences, Shanghai 200050 (China); Feng, Gaoming [United Lab, Semiconductor Manfacturing International Corporation, Shanghai 201203 (China)

    2014-11-28

    The RESET current of T-shaped phase change memory cells with 35 nm heating electrodes has been studied to understand the behavior of early cycling evolution. Results show that the RESET current has been significantly reduced after the early cycling evolution (1st RESET) operation. Compared the transmission electron microscope images, it is found that the hexagonal Ge{sub 2}Sb{sub 2}Te{sub 5} (GST) crystal grains are changed into the grains with face centered cubic structure after the early cycling evolution operation, which is taken as the major reason for the reduced RESET current, confirmed by a two-dimensional finite analysis and ab initio calculations.

  19. Fusion engineering design center

    International Nuclear Information System (INIS)

    In the spring of 1985, the Department of Energy (DOE) directed the Design Center to take a lead responsibility in assessing the engineering feasibility of a very compact tokamak experiment with copper coils. Following this assessment, the Design Center studied the Ignitor concept at the request of DOE and arrived at a design configuration. Many features of this configuration have been incorporated into the national baseline conceptual design for a Compact Ignition Tokamak (CIT). The Design Center continued to participate in the mirror program by contributing to the Minimars design effort, a two-year program to develop and describe an attractive tandem mirror reactor concept. The Design Center's principal role is in configuration definition of the candidate concepts. The Design Center continues to lead the engineering activities for the International Tokamak Reactor program. Advanced commercial tokamaks were studied by the Design Center as part of the Tokamak Power Systems Studies project coordinated by the DOE Office of Fusion Energy. The Design Center also provided design integration of the US effort. A cost accounting system that is applicable to all magnetic fusion reactor design studies was developed and applied to different confinement concepts and types of projects. The system provides the structure for development of a fusion cost database and validated cost estimating procedures

  20. Lens auto-centering

    Science.gov (United States)

    Lamontagne, Frédéric; Desnoyers, Nichola; Doucet, Michel; Côté, Patrice; Gauvin, Jonny; Anctil, Geneviève; Tremblay, Mathieu

    2015-09-01

    In a typical optical system, optical elements usually need to be precisely positioned and aligned to perform the correct optical function. This positioning and alignment involves securing the optical element in a holder or mount. Proper centering of an optical element with respect to the holder is a delicate operation that generally requires tight manufacturing tolerances or active alignment, resulting in costly optical assemblies. To optimize optical performance and minimize manufacturing cost, there is a need for a lens mounting method that could relax manufacturing tolerance, reduce assembly time and provide high centering accuracy. This paper presents a patent pending lens mounting method developed at INO that can be compared to the drop-in technique for its simplicity while providing the level of accuracy close to that achievable with techniques using a centering machine (usually innovative auto-centering method is based on the use of geometrical relationship between the lens diameter, the lens radius of curvature and the thread angle of the retaining ring. The autocentering principle and centering test results performed on real optical assemblies are presented. In addition to the low assembly time, high centering accuracy, and environmental robustness, the INO auto-centering method has the advantage of relaxing lens and barrel bore diameter tolerances as well as lens wedge tolerances. The use of this novel lens mounting method significantly reduces manufacturing and assembly costs for high performance optical systems. Large volume productions would especially benefit from this advancement in precision lens mounting, potentially providing a drastic cost reduction.

  1. Experiential self-understanding.

    Science.gov (United States)

    Bell, David; Leite, Adam

    2016-04-01

    The notion of insight is at one and the same time central to psychoanalysis and to the self-understanding that is part of everyday life. Through clinical material and critical engagement with contemporary philosophical work on self-knowledge, this paper clarifies one crucial aspect of this key notion. Self-understanding of the sort we have in mind, while of course involving cognitive elements, is not sufficiently accounted for by cognition about one's affects, motivations, or other aspects of the psyche, nor by the simple conjunction of such cognition with felt affect, motivational urges, etc. Nor is it best modelled in terms of internal self-observation. Rather, it is the product of an ongoing process of the unfolding articulation of one's psychic life. The notion of experience is important here in three ways. First, lived experience is that out of which the self-understanding arises. Second, this self-understanding is a development and articulation of these aspects of our inner lives; it is a part of that same lived perspective. And third, this understanding in turn shapes one's experience of one's inner world: as it is attained, one's experience of oneself thereby changes. Central here is the emphasis upon a developing process involving the ability to speak from one's subjective perspective while experiencing one's subjective perspective as the perspective that it is. PMID:26804793

  2. Promoting Physical Understanding through Peer Mentoring

    Science.gov (United States)

    Nossal, S. M.; Huesmann, A.; Hooper, E.; Moore, C.; Watson, L.; Trestrail, A.; Weber, J.; Timbie, P.; Jacob, A.

    2015-12-01

    The Physics Learning Center at the University of Wisconsin-Madison provides a supportive learning community for students studying introductory physics, as well as teaching and leadership experience for undergraduate Peer Mentor Tutors who receive extensive training and supervision. Many of our Peer Tutors were former Physics Learning Center participants. A central goal of the Physics Learning Center is to address achievement/equity gaps (e.g. race, gender, socio-economic status, disability, age, transfer status, etc.) for undergraduate students pursuing majors and coursework in STEM fields. Students meet twice a week in small learning teams of 3-8 students, facilitated by a trained Peer Mentor Tutor or staff member. These active learning teams focus on discussing core physical concepts and practicing problem-solving. The weekly training of the tutors addresses both teaching and mentoring issues in science education such as helping students to build confidence, strategies for assessing student understanding, and fostering a growth mindset. A second weekly training meeting addresses common misconceptions and strategies for teaching specific physics topics. For non-science majors we have a small Peer Mentor Tutor program for Physics in the Arts. We will discuss the Physics Learning Center's approaches to promoting inclusion, understanding, and confidence for both our participants and Peer Mentor Tutors, as well as examples from the geosciences that can be used to illustrate introductory physics concepts.

  3. Understanding Venus to understand the Earth

    Science.gov (United States)

    Widemann, T.; Tanga, P.

    2012-12-01

    Despite having almost the same size and bulk composition as the Earth, Venus possesses an extreme climate with a surface pressure of 90 bars and temperatures of 740 K. At visible wavelengths the Venus disk appears covered by thick clouds.The core atmospheric processes of Venus and the Earth are similar, despite the different, extraordinary paths they took since their simultaneous formation in the solar system's habitable zone. There are several indications that the composition of the Venus atmosphere has undergone large changes, such as an early runaway climate, and it is likely that the planet has lost a large amount of water through dissociation in the upper atmosphere due to ultraviolet radiation and the subsequent escape of hydrogen. SO2 is thought to originate from volcanism. H2O and SO2 react to form H2SO4 which condenses to form clouds. In past centuries, astronomers and explorers including Captain James Cook observed transits to measure the scale of the solar system. On 5-6 June 2012 we observed the last transit of Venus in this century. Close to the ingress and egress phases, the fraction of Venus disk outside the solar photosphere appears outlined by a thin arc of light, called the aureole. We have shown that the deviation due to refraction and the luminosity of the aureole are related to the local density scale height and the altitude of the refraction layer. As different portions of the arc can yield different values of these parameters, the rare transit event thus provides a unique insight of the Venus mesosphere. The polar region, significantly brighter in initial phases due to larger scale height of the polar mesosphere, appears consistently offset toward morning terminator by about 15deg. latitude, peaking at 75N at 6:00 local time. This result reflects local latitudinal structure in the polar mesosphere, either in temperature or aerosol altitude distribution. Detailed comparative climatology of Venus, an Earth-size planet and understanding why it

  4. ATHENA: Remote Sensing Science Center for Cultural Heritage in Cyprus

    Science.gov (United States)

    Hadjimitsis, Diofantos G.; Agapiou, Athos; Lysandrou, Vasiliki; Themistocleous, Kyriakos; Cuca, Branka; Lasaponara, Rosa; Masini, Nicola; Krauss, Thomas; Cerra, Daniele; Gessner, Ursula; Schreier, Gunter

    2016-04-01

    The Cultural Heritage (CH) sector, especially those of monuments and sites has always been facing a number of challenges from environmental pressure, pollution, human intervention from tourism to destruction by terrorism.Within this context, CH professionals are seeking to improve currently used methodologies, in order to better understand, protect and valorise the common European past and common identity. "ATHENA" H2020-TWINN-2015 project will seek to improve and expand the capabilities of the Cyprus University of Technology, involving professionals dealing with remote sensing technologies for supporting CH sector from the National Research Center of Italy (CNR) and German Aerospace Centre (DLR). The ATHENA centre will be devoted to the development, introduction and systematic use of advanced remote sensing science and technologies in the field of archaeology, built cultural heritage, their multi-temporal analysis and interpretation and the distant monitoring of their natural and anthropogenic environment in the area of Eastern Mediterranean.

  5. Narrative and psychological understanding.

    Science.gov (United States)

    Josselson, R

    1995-11-01

    NARRATIVE understanding is based in philosophical hermeneutics, a tradition regnant in Europe but only recently penetrating the American intellectual consciousness. Within this epistemology, there is only the text (communicated in language), which is itself about a text, and dialogue within and among these texts. There is no priori place to stand to make truth claims: there are only interpretations made from a particular historical and value-implicated stance. The "hermeneutic circle" describes a process in which understanding requires reference to a priori understandings such that knowledge accrues in a circular, dialectic fashion. No knowledge can be independent of context or interpreter. The enterprise of science then becomes conversation from which emerge consensual ideas that constitute ways of perceiving and interpreting future texts. PMID:8746491

  6. NEED OF INTERNATIONAL UNDERSTANDING

    Directory of Open Access Journals (Sweden)

    MADHURI SANJAY YADAV

    2013-02-01

    Full Text Available Today every member of the society is facing social, political, economical, environmental issues such as scarcity of natural sources, natural as well as human disasters, stress etc. These are the common issues of all the people of varied societies in the world. There is need to find out solution for these problems. Education is the best mean to solve various issues of the society. The present research article aimed to focus the need of inculcating international understanding among the students of today's age. The researcher has integrated the topics such as the meaning of international understanding, need and importance of it. The researcher has tried to put various ways for inculcation of international understanding through education.

  7. Understanding Organizational Advantage

    DEFF Research Database (Denmark)

    Stea, Diego; Linder, Stefan; Foss, Nicolai Juul

    2015-01-01

    The attention-based view (ABV) of the firm highlights the role of decision makers’ attention in firm behavior. The ABV vastly improves our understanding of decision makers’ focus of attention; how that focus is situated in an organization’s procedural and communication channels; and how the...... distribution of the focus of attention among decision makers participating in those procedural and communication channels affects their understanding of a situation, their motivation to act, and, ultimately, their behavior. Significant progress has been made in recent years in refining and extending the ABV...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Budget Proposal NCI Congressional Justification NCI Budget Fact Book Careers at NCI Visitor Information Legislative Activities Hearings & ... Plan & Budget Proposal Congressional Justification NCI Budget Fact Book Legislative Activities Hearings & Testimonies Current Congress Legislative History ...

  9. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Types Recurrent Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia Lung ... Advisory Board Meetings Cancer Currents Blog Research Findings Drug Approvals Precision Medicine Leadership Views 2017 Annual Plan & ...

  10. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Currents Blog Research Findings Drug Approvals Precision Medicine Leadership Views 2017 Annual Plan & Budget Proposal All Press ... NCI NCI Overview History Contributing to Cancer Research Leadership Director's Page Previous NCI Directors NCI Organization Advisory ...

  11. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... About the Annual Plan & Budget Proposal NCI Congressional Justification NCI Budget Fact Book Careers at NCI Visitor ... Current Year Budget Annual Plan & Budget Proposal Congressional Justification NCI Budget Fact Book Legislative Activities Hearings & Testimonies ...

  12. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Currents Blog Research Findings Drug Approvals Precision Medicine Leadership Views All Press Releases 2016 2015 2014 2013 ... NCI NCI Overview History Contributing to Cancer Research Leadership Director's Page Previous NCI Directors NCI Organization Advisory ...

  13. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Media Media Contacts Multicultural Media Outreach Program Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog Research Findings Drug Approvals Precision Medicine Leadership Views 2017 ...

  14. Backward Design: Targeting Depth of Understanding for All Learners

    Science.gov (United States)

    Childre, Amy; Sands, Jennifer R.; Pope, Saundra Tanner

    2009-01-01

    Curriculum design is at the center of developing student ability to construct understanding. Without appropriately designed curriculum, instruction can be ineffective at scaffolding understanding. Often students with disabilities need more explicit instruction or guidance in applying their schema to new information. Thus, instruction must not only…

  15. Understanding Tax Evasion Dynamics

    OpenAIRE

    Eduardo Engel; James R. Hines Jr.

    1999-01-01

    Americans who are caught evading taxes in one year may be audited for prior years. While the IRS does not disclose its method of selecting tax returns to audit, it is widely believed that a taxpayer's probability of being audited is an increasing function of current evasion. Under these circumstances, a rational taxpayer's current evasion is a decreasing function of prior evasion, since, if audited and caught for evading this year, the taxpayer may incur penalties for past evasions. The paper...

  16. Status of center dominance in various center gauges

    OpenAIRE

    Faber, M; Greensite, J.; Olejnik, S.

    2002-01-01

    We review arguments for center dominance in center gauges where vortex locations are correctly identified. We introduce an appealing interpretation of the maximal center gauge, discuss problems with Gribov copies, and a cure to the problems through the direct Laplacian center gauge. We study correlations between direct and indirect Laplacian center gauges.

  17. Center for Contaminated Sediments

    Data.gov (United States)

    Federal Laboratory Consortium — The U.S. Army Corps of Engineers Center for Contaminated Sediments serves as a clearinghouse for technology and expertise concerned with contaminated sediments. The...

  18. HUD Homeownership Centers

    Data.gov (United States)

    Department of Housing and Urban Development — HUD Homeownership Centers (HOCs) insure single family Federal Housing Administration (FHA) mortgages and oversee the selling of HUD homes. FHA has four...

  19. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Chairman Commissioners Contact Information Agency Reports Legislative Affairs Job Opportunities Inspector General Safety Guides Safety Education Centers OnSafety Blog Neighborhood Safety Network Community Outreach ...

  20. National Pesticide Information Center

    Science.gov (United States)

    National Pesticide Information Center npic@ace.orst.edu 1.800.858.7378 Index A B C D E F ... Your Pest Control Your Pest Integrated Pest Management Pesticide Ingredients Active Ingredients Other/Inert Ingredients Pesticide Products ...