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Sample records for center microquasar 1e

  1. The proton microquasar

    OpenAIRE

    Vila, Gabriela S.; Romero, Gustavo E.

    2008-01-01

    We present a model for high-energy emission in microquasars where the energy content of the jets is dominated by relativistic protons. We also include a primary leptonic component. Particles are accelerated up to relativistic energies in a compact region located near the base of the jet, where most of the emission is produced. We calculate the production spectrum due to proton and electron synchrotron radiation and photohadronic interactions. The target field for proton-photon collisions is p...

  2. Microquasar-AGN-GRB Connections

    CERN Document Server

    Mirabel, I F

    2004-01-01

    I review the progress made on the physics of black hole systems in the context of the analogy between AGN and microquasars that was proposed one decade ago. If the emerging empirical correlations between the observational properties of stellar and supermassive black holes will become more robust, we will use them to determine the mass and spin of black holes, independently of theoretical models. Microquasars are fossils of sources of Gamma-ray bursts (GRBs) of long duration, and their kinematics provides observational clues on the physics of collapsars. If jets in GRBs, microquasars and AGN are due to a unique universal magnetohydrodynamic mechanism, synergy between the research on these three different classes of cosmic objects will lead to further progress in black hole physics and astrophysics. The potential contributions with INTEGRAL in this field of research are also discussed. It is shown that the Galactic Plane Survey (GPS) with INTEGRAL is unraveling new extragalactic sources of hard x-rays behind th...

  3. The precessing jets of 1E 1740.7-2942

    CERN Document Server

    Luque-Escamilla, Pedro L; Martinez-Aroza, Josee

    2015-01-01

    Context. 1E 1740.7-2942 is believed to be one of the two prototypical microquasars towards the Galactic center region whose X-ray states strongly resemble those of Cygnus X-1. Yet, the bipolar radio jets of 1E 1740.7-2942 are very reminiscent of a radio galaxy. The true nature of the object has thus remained an open question for nearly a quarter of a century. Aims. Our main goal here is to confirm the Galactic membership of 1E 1740.7-2942 by searching for morphological changes of its extended radio jets in human timescales. This work was triggered as a result of recent positive detection of fast structural changes in the large-scale jets of its 'twin' GRS 1758-258. Methods. We carried out an in-depth exploration of the VLA public archives and fully recalibrated all 1E 1740.7-2942 extended data sets in the C configuration of the array. We obtained and analyzed matching beam radio maps for five epochs, covering years 1992, 1993, 1994, 1997 and 2000, with an angular resolution of a few arcseconds. Results. We cl...

  4. Jet-Induced Nucleosynthesis in Misaligned Microquasars

    CERN Document Server

    Butt, Y M; Prantzos, N; Butt, Yousaf M.; Maccarone, Thomas J.; Prantzos, Nikos

    2002-01-01

    The jet axes and the orbital planes of microquasar systems are usually assumed to be approximately perpendicular, eventhough this is not currently an observational requirement. On the contrary, in one of the few systems where the relative orientations are well-constrained, V4641Sgr, the jet axis is known to lie not more than ~35 degrees from the binary plane. Such a jet, lying close to the binary plane, and traveling at a significant fraction of the speed of light may periodically impact the secondary star initiating nuclear reactions on its surface. The integrated yield of such nuclear reactions over the age of the binary system (less the radiative mass loss) will detectably alter the elemental abundances of the companion star. This scenario may explain the anomalously high Li enhancements (roughly ~20-200 times the sun's photospheric value; or, equivalently, 0.1-1 times the average solar system value) seen in the companions of some black-hole X-ray binary systems. (Such enhancements are puzzling since Li nu...

  5. Understanding the Very High-Energy Emission from Microquasars

    CERN Document Server

    Bosch-Ramon, Valenti

    2008-01-01

    Microquasars are X-ray binaries with relativistic jets. These jets are powerful energy carriers, thought to be fed by accretion, which produce non-thermal emission at different energy bands. To date, several Galactic sources showing extended radio emission, among them at least one confirmed microquasar, Cygnus X-1, have been detected in the TeV range. All of them show complex patterns of spectral and temporal behavior. In this work, we discuss the physics behind the very high-energy emission in microquasars. In concrete, we focus on the microquasar Cygnus X-1, and also in the other two TeV binaries with detected extended outflows, LS 5039 and LS I +61 303, pointing out relevant aspects of the complex phenomena occurring in them. We conclude that the TeV emission is likely of leptonic origin, although hadrons cannot be discarded. In addition, efficient electromagnetic cascades can hardly develop since even relatively low magnetic fields suppress them. Also, the modeling of the radiation from some of the detect...

  6. Extreme particle acceleration in the microquasar Cygnus X-3.

    Science.gov (United States)

    Tavani, M; Bulgarelli, A; Piano, G; Sabatini, S; Striani, E; Evangelista, Y; Trois, A; Pooley, G; Trushkin, S; Nizhelskij, N A; McCollough, M; Koljonen, K I I; Pucella, G; Giuliani, A; Chen, A W; Costa, E; Vittorini, V; Trifoglio, M; Gianotti, F; Argan, A; Barbiellini, G; Caraveo, P; Cattaneo, P W; Cocco, V; Contessi, T; D'Ammando, F; Del Monte, E; De Paris, G; Di Cocco, G; Di Persio, G; Donnarumma, I; Feroci, M; Ferrari, A; Fuschino, F; Galli, M; Labanti, C; Lapshov, I; Lazzarotto, F; Lipari, P; Longo, F; Mattaini, E; Marisaldi, M; Mastropietro, M; Mauri, A; Mereghetti, S; Morelli, E; Morselli, A; Pacciani, L; Pellizzoni, A; Perotti, F; Picozza, P; Pilia, M; Prest, M; Rapisarda, M; Rappoldi, A; Rossi, E; Rubini, A; Scalise, E; Soffitta, P; Vallazza, E; Vercellone, S; Zambra, A; Zanello, D; Pittori, C; Verrecchia, F; Giommi, P; Colafrancesco, S; Santolamazza, P; Antonelli, A; Salotti, L

    2009-12-01

    Super-massive black holes in active galaxies can accelerate particles to relativistic energies, producing jets with associated gamma-ray emission. Galactic 'microquasars', which are binary systems consisting of a neutron star or stellar-mass black hole accreting gas from a companion star, also produce relativistic jets, generally together with radio flares. Apart from an isolated event detected in Cygnus X-1, there has hitherto been no systematic evidence for the acceleration of particles to gigaelectronvolt or higher energies in a microquasar, with the consequence that we are as yet unsure about the mechanism of jet energization. Here we report four gamma-ray flares with energies above 100 MeV from the microquasar Cygnus X-3 (an exceptional X-ray binary that sporadically produces radio jets). There is a clear pattern of temporal correlations between the gamma-ray flares and transitional spectral states of the radio-frequency and X-ray emission. Particle acceleration occurred a few days before radio-jet ejections for two of the four flares, meaning that the process of jet formation implies the production of very energetic particles. In Cygnus X-3, particle energies during the flares can be thousands of times higher than during quiescent states. PMID:19935645

  7. Gigantic Cosmic Corkscrew Reveals New Details About Mysterious Microquasar

    Science.gov (United States)

    2004-10-01

    Making an extra effort to image a faint, gigantic corkscrew traced by fast protons and electrons shot out from a mysterious microquasar paid off for a pair of astrophysicists who gained new insights into the beast's inner workings and also resolved a longstanding dispute over the object's distance. Microquasar SS 433 VLA Image of Microquasar SS 433 CREDIT: Blundell & Bowler, NRAO/AUI/NSF (Click on Image for Larger Version) The astrophysicists used the National Science Foundation's Very Large Array (VLA) radio telescope to capture the faintest details yet seen in the plasma jets emerging from the microquasar SS 433, an object once dubbed the "enigma of the century." As a result, they have changed scientists' understanding of the jets and settled the controversy over its distance "beyond all reasonable doubt," they said. SS 433 is a neutron star or black hole orbited by a "normal" companion star. The powerful gravity of the neutron star or black hole draws material from the stellar wind of its companion into an accretion disk of material tightly circling the dense central object prior to being pulled onto it. This disk propels jets of fast protons and electrons outward from its poles at about a quarter of the speed of light. The disk in SS 433 wobbles like a child's top, causing its jets to trace a corkscrew in the sky every 162 days. The new VLA study indicates that the speed of the ejected particles varies over time, contrary to the traditional model for SS 433. "We found that the actual speed varies between 24 percent to 28 percent of light speed, as opposed to staying constant," said Katherine Blundell, of the University of Oxford in the United Kingdom. "Amazingly, the jets going in both directions change their speeds simultaneously, producing identical speeds in both directions at any given time," Blundell added. Blundell worked with Michael Bowler, also of Oxford. The scientists' findings have been accepted by the Astrophysical Journal Letters. SS 433 New VLA

  8. VLBA "Movie" Gives Scientists New Insights On Workings of Mysterious Microquasars

    Science.gov (United States)

    2004-01-01

    433 wobbles like a child's top, causing its jets to move in a circle every 164 days. By imaging SS 433 daily, the astronomers were able to trace individual ejections of material in these jets as they moved outward from the center. In addition, they could track the jets' precession, the movement caused by the disk's wobble. In other microquasars, blobs of material shot from the core become fainter, as seen with radio telescopes, as they move outward. However, in SS 433, blobs routinely brighten at specific distances from the core. From earlier studies, researchers had concluded that such brightening always occurs at one specific distance. The VLBA movie shows, instead, that there are multiple brightening regions and not all blobs brighten at all the regions. "We think the ejected material brightens because it's slamming into something," Rupen said. "However, whatever it's hitting has to be replenished somehow so that the brightening can occur again when the jet sweeps through that area the next time," he added. "It also appears that it isn't always replenished, because the brightening doesn't always happen," Mioduszewski pointed out. The VLBA movie revealed vital new information about another part of SS 433 -- material moving outward from the core, but not part of the superfast jets. This material moves outward in a direction not quite perpendicular to the direction of the jets. Discovered with the VLBA in 2000, this material had been seen only in one-time snapshots before, but the movie shows the steady evolution of its movement for the first time. That motion was the key to a possible answer to two riddles -- the source of the slower-moving material itself and the source of whatever the jet blobs are hitting when they brighten. "What seems most plausible to us is that the accretion disk is putting out a broad wind," Rupen explained. That broad wind from the disk hits a denser wind coming from the "normal" companion star to generate the radio waves seen coming from

  9. Sensitivity of an underwater Cerenkov km3 telescope to TeV neutrinos from Galactic Microquasars

    CERN Document Server

    Distefano, C; Ambriola, M; Ameli, F; Amore, I; Anghinolfi, M; Anzalone, A; Barbarino, G C; Barbarito, E; Battaglieri, M; Bellotti, R; Beverini, N; Bonori, M; Bouhadef, B; Brescia, M; Cacopardo, G; Cafagna, F; Capone, A; Caponetto, L; Castorina, E; Ceres, A; Chiarusi, T; Circella, M; Cocimano, R; Coniglione, R; Cordelli, M; Costa, M; Cuneo, S; D'Amico, A; De Bonis, G; De Marzo, C; De Rosa, G; De Vita, R; Falchini, E; Fiorello, C; Flaminio, V; Fratini, K; Gabrielli, A; Galeotti, S; Gandolfi, E; Giacomelli, G; Giorgi, F; Grimaldi, A; Habel, R; Leonora, E; Lonardo, A; Longo, G; Lo Presti, D; Lucarelli, F; Maccioni, E; Margiotta, A; Martini, A; Masullo, R; Megna, R; Migneco, E; Mongelli, M; Montaruli, T; Morganti, M; Musumeci, M; Nicolau, C A; Orlando, A; Osipenko, M; Osteria, G; Papaleo, R; Pappalardo, V; Petta, C; Piattelli, P; Raia, G; Randazzo, N; Reito, S; Ricco, G; Riccobene, G; Ripani, M; Rovelli, A; Ruppi, M; Russo, G V; Russo, S; Sapienza, P; Sedita, M; Shirokov, E; Simeone, F; Sipala, V; Spurio, M; Taiuti, M; Terreni, G; Trasatti, L; Urso, S; Valente, V; Vicini, P

    2006-01-01

    In this paper are presented the results of Monte Carlo simulations on the capability of the proposed NEMO-km$^3$ telescope to detect TeV muon neutrinos from Galactic microquasars. For each known microquasar we compute the number of detectable events, together with the atmospheric neutrino and muon background events. We also discuss the detector sensitivity to neutrino fluxes expected from known microquasars, optimizing the event selection also to reject the background; the number of events surviving the event selection are given.

  10. Positron annihilation signatures associated with the outburst of the microquasar V404 Cygni

    CERN Document Server

    Siegert, Thomas; Greiner, Jochen; Krause, Martin G H; Beloborodov, Andrei M; Bel, Marion Cadolle; Guglielmetti, Fabrizia; Rodriguez, Jerome; Strong, Andrew W; Zhang, Xiaoling

    2016-01-01

    Microquasars are stellar-mass black holes accreting matter from a companion star and ejecting plasma jets at almost the speed of light. They are analogues of quasars that contain supermassive black holes of $10^6$ to $10^{10}$ solar masses. Accretion in microquasars varies on much shorter timescales than in quasars and occasionally produces exceptionally bright X-ray flares. How the flares are produced is unclear, as is the mechanism for launching the relativistic jets and their composition. An emission line near 511 kiloelectronvolts has long been sought in the emission spectrum of microquasars as evidence for the expected electron-positron plasma. Transient high-energy spectral features have been reported in two objects, but their positron interpretation remains contentious. Here we report observations of $\\gamma$-ray emission from the microquasar V404 Cygni during a recent period of strong flaring activity. The emission spectrum around 511 kiloelectronvolts shows clear signatures of variable positron annih...

  11. NuSTAR and integral observations of a low/hard state of 1E1740.7-2942

    International Nuclear Information System (INIS)

    The microquasar 1E1740.7-2942, also known as the 'Great Annihilator,' was observed by NuSTAR in the summer of 2012. We have analyzed in detail two observations taken ∼2 weeks apart, for which we measure hard and smooth spectra typical of the low/hard state. A few weeks later the source flux declined significantly. Nearly simultaneous coverage by INTEGRAL is available from its Galactic Center monitoring campaign lasting ∼2.5 months. These data probe the hard state spectrum from 1E1740.7-2942 before the flux decline. We find good agreement between the spectra taken with IBIS/ISGRI and NuSTAR, with the measurements being compatible with a change in flux with no spectral variability. We present a detailed analysis of the NuSTAR spectral and timing data and upper limits for reflection of the high energy emission. We show that the high energy spectrum of this X-ray binary is well described by thermal Comptonization.

  12. Variable Very High Energy Gamma-ray Emission from the Microquasar LS I +61 303

    OpenAIRE

    MAGIC Collaboration; Albert, J

    2006-01-01

    Microquasars are binary star systems with relativistic radio-emitting jets. They are potential sources of cosmic rays and laboratories for elucidating the physics of relativistic jets. Here we report the detection of variable gamma-ray emission above 100 gigaelectron volts from the microquasar LS I +61 303. Six orbital cycles were recorded. Several detections occur at a similar orbital phase, suggesting the emission is periodic. The strongest gamma-ray emission is not observed when the two st...

  13. Variable Very-High-Energy Gamma-Ray Emission from the Microquasar LS I +61 303

    OpenAIRE

    Antoranz Canales, Pedro; Barrio Uña, Juan Abel; Contreras González, José Luis; Fonseca González, Mª Victoria; López Moya, Marcos; Miranda Pantoja, José Miguel

    2006-01-01

    Microquasars are binary star systems with relativistic radio-emitting jets. They are potential sources of cosmic rays and can be used to elucidate the physics of relativistic jets. We report the detection of variable gamma-ray emission above 100 gigaelectron volts from the microquasar LS I 61 + 303. Six orbital cycles were recorded. Several detections occur at a similar orbital phase, which suggests that the emission is periodic. The strongest gamma-ray emission is not observed when the two s...

  14. Veritas observations of the microquasar Cygnus X-3

    International Nuclear Information System (INIS)

    We report results from TeV gamma-ray observations of the microquasar Cygnus X-3. The observations were made with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) over a time period from 2007 June 11 to 2011 November 28. VERITAS is most sensitive to gamma rays at energies between 85 GeV and 30 TeV. The effective exposure time amounts to a total of about 44 hr, with the observations covering six distinct radio/X-ray states of the object. No significant TeV gamma-ray emission was detected in any of the states, nor with all observations combined. The lack of a positive signal, especially in the states where GeV gamma rays were detected, places constraints on TeV gamma-ray production in Cygnus X-3. We discuss the implications of the results.

  15. Veritas observations of the microquasar Cygnus X-3

    Energy Technology Data Exchange (ETDEWEB)

    Archambault, S. [Physics Department, McGill University, Montreal, QC H3A 2T8 (Canada); Beilicke, M.; Buckley, J. H.; Bugaev, V. [Department of Physics, Washington University, St. Louis, MO 63130 (United States); Benbow, W.; Cerruti, M. [Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645 (United States); Berger, K. [Department of Physics and Astronomy and the Bartol Research Institute, University of Delaware, Newark, DE 19716 (United States); Bird, R. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Bouvier, A. [Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064 (United States); Byrum, K. [Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439 (United States); Chen, X.; Federici, S. [Institute of Physics and Astronomy, University of Potsdam, D-14476 Potsdam-Golm (Germany); Ciupik, L. [Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605 (United States); Connolly, M. P. [School of Physics, National University of Ireland Galway, University Road, Galway (Ireland); Cui, W.; Feng, Q. [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Duke, C. [Department of Physics, Grinnell College, Grinnell, IA 50112-1690 (United States); Dumm, J. [School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States); Errando, M. [Department of Physics and Astronomy, Barnard College, Columbia University, NY 10027 (United States); Falcone, A., E-mail: avarlott@purdue.edu, E-mail: cui@purdue.edu [Department of Astronomy and Astrophysics, 525 Davey Lab, Pennsylvania State University, University Park, PA 16802 (United States); Collaboration: VERITAS Collaboration) and; Smithsonian Astrophysical Observatory; and others

    2013-12-20

    We report results from TeV gamma-ray observations of the microquasar Cygnus X-3. The observations were made with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) over a time period from 2007 June 11 to 2011 November 28. VERITAS is most sensitive to gamma rays at energies between 85 GeV and 30 TeV. The effective exposure time amounts to a total of about 44 hr, with the observations covering six distinct radio/X-ray states of the object. No significant TeV gamma-ray emission was detected in any of the states, nor with all observations combined. The lack of a positive signal, especially in the states where GeV gamma rays were detected, places constraints on TeV gamma-ray production in Cygnus X-3. We discuss the implications of the results.

  16. VERITAS Observations of the Microquasar Cygnus X-3

    CERN Document Server

    Archambault, S; Benbow, W; Berger, K; Bird, R; Bouvier, A; Buckley, J H; Bugaev, V; Byrum, K; Cerruti, M; Chen, X; Ciupik, L; Connolly, M P; Cui, W; Duke, C; Dumm, J; Errando, M; Falcone, A; Federici, S; Feng, Q; Finley, J P; Fortson, L; Furniss, A; Galante, N; Gillanders, G H; Griffin, S; Griffiths, S T; Grube, J; Gyuk, G; Hanna, D; Holder, J; Hughes, G; Humensky, T B; Kaaret, P; Kertzman, M; Khassen, Y; Kieda, D; Krawczynski, H; Lang, M J; Madhavan, A S; Maier, G; Majumdar, P; McArthur, S; McCann, A; Moriarty, P; Mukherjee, R; Nieto, D; de Bhróithe, A O'Faoláin; Ong, R A; Otte, A N; Pandel, D; Park, N; Perkins, J S; Pohl, M; Popkow, A; Prokoph, H; Quinn, J; Ragan, K; Rajotte, J; Reyes, L C; Reynolds, P T; Richards, G T; Roache, E; Sembroski, G H; Sheidaei, F; Smith, A W; Staszak, D; Telezhinsky, I; Theiling, M; Tucci, J V; Tyler, J; Varlotta, A; Vincent, S; Wakely, S P; Weekes, T C; Weinstein, A; Williams, D A; Zitzer, B; McCollough, M L

    2013-01-01

    We report results from TeV gamma-ray observations of the microquasar Cygnus X-3. The observations were made with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) over a time period from 2007 June 11 to 2011 November 28. VERITAS is most sensitive to gamma rays at energies between 85 GeV to 30 TeV. The effective exposure time amounts to a total of about 44 hours, with the observations covering six distinct radio/X-ray states of the object. No significant TeV gamma-ray emission was detected in any of the states, nor with all observations combined. The lack of a positive signal, especially in the states where GeV gamma rays were detected, places constraints on TeV gamma-ray production in Cygnus X-3. We discuss the implications of the results.

  17. GMRT radio observations of microquasar GRS 1915+105

    CERN Document Server

    Yadav, J S; Rao, A P; Pooley, G G

    2002-01-01

    We have observed microquasar GRS 1915+105 at 1.28 GHz for 8 days from June 18 to July 1, 2001 using Giant Metrewave Radio Telescope (GMRT). We have seen several isolated radio baby flares of varying intensity and duration. We have also observed broad composite flares with rise and decay times of few hours on June 28-29, 2001 few days prior to when source went to the ``plateau radio state'' on 3rd July, 2001. These broad radio flares consist of several overlapping baby radio flares. The source was in the low-hard X-ray state during this period. We compare these results with 15 GHz radio data from the Ryle telescope.

  18. Positron annihilation signatures associated with the outburst of the microquasar V404 Cygni.

    Science.gov (United States)

    Siegert, Thomas; Diehl, Roland; Greiner, Jochen; Krause, Martin G H; Beloborodov, Andrei M; Bel, Marion Cadolle; Guglielmetti, Fabrizia; Rodriguez, Jerome; Strong, Andrew W; Zhang, Xiaoling

    2016-03-17

    Microquasars are stellar-mass black holes accreting matter from a companion star and ejecting plasma jets at almost the speed of light. They are analogues of quasars that contain supermassive black holes of 10(6) to 10(10) solar masses. Accretion in microquasars varies on much shorter timescales than in quasars and occasionally produces exceptionally bright X-ray flares. How the flares are produced is unclear, as is the mechanism for launching the relativistic jets and their composition. An emission line near 511 kiloelectronvolts has long been sought in the emission spectrum of microquasars as evidence for the expected electron-positron plasma. Transient high-energy spectral features have been reported in two objects, but their positron interpretation remains contentious. Here we report observations of γ-ray emission from the microquasar V404 Cygni during a recent period of strong flaring activity. The emission spectrum around 511 kiloelectronvolts shows clear signatures of variable positron annihilation, which implies a high rate of positron production. This supports the earlier conjecture that microquasars may be the main sources of the electron-positron plasma responsible for the bright diffuse emission of annihilation γ-rays in the bulge region of our Galaxy. Additionally, microquasars could be the origin of the observed megaelectronvolt continuum excess in the inner Galaxy. PMID:26934231

  19. Positron annihilation signatures associated with the outburst of the microquasar V404 Cygni

    Science.gov (United States)

    Siegert, Thomas; Diehl, Roland; Greiner, Jochen; Krause, Martin G. H.; Beloborodov, Andrei M.; Bel, Marion Cadolle; Guglielmetti, Fabrizia; Rodriguez, Jerome; Strong, Andrew W.; Zhang, Xiaoling

    2016-03-01

    Microquasars are stellar-mass black holes accreting matter from a companion star and ejecting plasma jets at almost the speed of light. They are analogues of quasars that contain supermassive black holes of 106 to 1010 solar masses. Accretion in microquasars varies on much shorter timescales than in quasars and occasionally produces exceptionally bright X-ray flares. How the flares are produced is unclear, as is the mechanism for launching the relativistic jets and their composition. An emission line near 511 kiloelectronvolts has long been sought in the emission spectrum of microquasars as evidence for the expected electron-positron plasma. Transient high-energy spectral features have been reported in two objects, but their positron interpretation remains contentious. Here we report observations of γ-ray emission from the microquasar V404 Cygni during a recent period of strong flaring activity. The emission spectrum around 511 kiloelectronvolts shows clear signatures of variable positron annihilation, which implies a high rate of positron production. This supports the earlier conjecture that microquasars may be the main sources of the electron-positron plasma responsible for the bright diffuse emission of annihilation γ-rays in the bulge region of our Galaxy. Additionally, microquasars could be the origin of the observed megaelectronvolt continuum excess in the inner Galaxy.

  20. Jet-induced star formation by a microquasar

    CERN Document Server

    Mirabel, I F; Rodriguez, L F; Sauvage, M

    2014-01-01

    Theoretical and observational work show that jets from AGN can trigger star formation. However, in the Milky Way the first -and so far- only clear case of relativistic jets inducing star formation has been found in the surroundings of the microquasar GRS 1915+105. Here we summarize the multiwavelength observations of two compact star formation IRAS sources axisymmetrically located and aligned with the position angle of the sub-arcsec relativistic jets from the stellar black hole binary GRS 1915+105 (Mirabel & Rodriguez 1994). The observations of these two star forming regions at centimeter (Rodriguez & Mirabel 1998), millimeter and infrared (Chaty et al. 2001) wavelengths had suggested -despite the large uncertainties in the distances a decade ago- that the jets from GRS 1915+105 are triggering along the radio jet axis the formation of massive stars in a radio lobe of bow shock structure. Recently, Reid et al.(2014) found that the jet source and the IRAS sources are at the same distance, enhancing the...

  1. Alignment Timescale of the Microquasar GRO J1655-40

    CERN Document Server

    Martin, Rebecca G; Pringle, J E

    2008-01-01

    The microquasar GRO J1655-40 has a black hole with spin angular momentum apparently misaligned to the orbital plane of its companion star. We analytically model the system with a steady state disc warped by Lense-Thirring precession and find the timescale for the alignment of the black hole with the binary orbit. We make detailed stellar evolution models so as to estimate the accretion rate and the lifetime of the system in this state. The secondary can be evolving at the end of the main sequence or across the Hertzsprung gap. The mass-transfer rate is typically fifty times higher in the latter case but we find that, in both cases, the lifetime of the mass transfer state is at most a few times the alignment timescale. The fact that the black hole has not yet aligned with the orbital plane is therefore consistent with either model. We conclude that the system may or may not have been counter-aligned after its supernova kick but that it is most likely to be close to alignment rather than counteralignment now.

  2. Looking to the future: using IR interferometry to study microquasars

    CERN Document Server

    Markoff, Sera

    2008-01-01

    Infrared interferometry is currently in a rapid development phase, with new instrumentation soon achieving milliarcsecond spatial resolutions for faint sources and astrometry on the order of 10 microarcseconds. For jet studies in particular, the next generation of instruments will bring us closer to the event horizon of supermassive black holes such as Sgr A*, and the region where jet launching must occur. But a new possibility to study microquasars in general and jet physics in particular may also arise, using techniques similar to those employed for finding faint exoplanets around stars. The compact, steady jets observed in the hard state of X-ray binaries display a flat/inverted spectrum from the lower radio wavelengths up through at least the far-IR band. Somewhere above this band, a turnover is predicted where the jets become optically thin, revealing a power-law spectrum. This break may have been observed directly in GX339-4, but in most sources such a feature is likely hidden under bright emission from...

  3. Sensitivity of an underwater Čerenkov km 3 telescope to TeV neutrinos from Galactic microquasars

    Science.gov (United States)

    Aiello, S.; Ambriola, M.; Ameli, F.; Amore, I.; Anghinolfi, M.; Anzalone, A.; Barbarino, G.; Barbarito, E.; Battaglieri, M.; Bellotti, R.; Beverini, N.; Bonori, M.; Bouhadef, B.; Brescia, M.; Cacopardo, G.; Cafagna, F.; Capone, A.; Caponetto, L.; Castorina, E.; Ceres, A.; Chiarusi, T.; Circella, M.; Cocimano, R.; Coniglione, R.; Cordelli, M.; Costa, M.; Cuneo, S.; D'Amico, A.; De Bonis, G.; De Marzo, C.; De Rosa, G.; De Vita, R.; Distefano, C.; Falchini, E.; Fiorello, C.; Flaminio, V.; Fratini, K.; Gabrielli, A.; Galeotti, S.; Gandolfi, E.; Giacomelli, G.; Giorgi, F.; Grimaldi, A.; Habel, R.; Leonora, E.; Lonardo, A.; Longo, G.; Lo Presti, D.; Lucarelli, F.; Maccioni, E.; Margiotta, A.; Martini, A.; Masullo, R.; Megna, R.; Migneco, E.; Mongelli, M.; Montaruli, T.; Morganti, M.; Musumeci, M.; Nicolau, C. A.; Orlando, A.; Osipenko, M.; Osteria, G.; Papaleo, R.; Pappalardo, V.; Petta, C.; Piattelli, P.; Raia, G.; Randazzo, N.; Reito, S.; Ricco, G.; Riccobene, G.; Ripani, M.; Rovelli, A.; Ruppi, M.; Russo, G. V.; Russo, S.; Sapienza, P.; Sedita, M.; Shirokov, E.; Simeone, F.; Sipala, V.; Spurio, M.; Taiuti, M.; Terreni, G.; Trasatti, L.; Urso, S.; Valente, V.; Vicini, P.

    2007-09-01

    In this paper are presented the results of Monte Carlo simulations on the capability of the proposed NEMO-km 3 telescope to detect TeV muon neutrinos from Galactic microquasars. For each known microquasar we compute the number of detectable events, together with the atmospheric neutrino and muon background events. We also discuss the detector sensitivity to neutrino fluxes expected from known microquasars, optimizing the event selection also to reject the background; the number of events surviving the event selection are given. The best candidates are the steady microquasars SS433 and GX339-4 for which we estimate a sensitivity of about 5 × 10 -11 erg/cm 2 s; the predicted fluxes are expected to be well above this sensitivity. For bursting microquasars the most interesting candidates are Cygnus X-3, GRO J1655-40 and XTE J1118+480: their analyses are more complicated because of the stochastic nature of the bursts.

  4. Variable very-high-energy gamma-ray emission from the microquasar LS I +61 303.

    Science.gov (United States)

    Albert, J; Aliu, E; Anderhub, H; Antoranz, P; Armada, A; Asensio, M; Baixeras, C; Barrio, J A; Bartelt, M; Bartko, H; Bastieri, D; Bavikadi, S R; Bednarek, W; Berger, K; Bigongiari, C; Biland, A; Bisesi, E; Bock, R K; Bordas, P; Bosch-Ramon, V; Bretz, T; Britvitch, I; Camara, M; Carmona, E; Chilingarian, A; Ciprini, S; Coarasa, J A; Commichau, S; Contreras, J L; Cortina, J; Curtef, V; Danielyan, V; Dazzi, F; De Angelis, A; de Los Reyes, R; De Lotto, B; Domingo-Santamaría, E; Dorner, D; Doro, M; Errando, M; Fagiolini, M; Ferenc, D; Fernández, E; Firpo, R; Flix, J; Fonseca, M V; Font, L; Fuchs, M; Galante, N; Garczarczyk, M; Gaug, M; Giller, M; Goebel, F; Hakobyan, D; Hayashida, M; Hengstebeck, T; Höhne, D; Hose, J; Hsu, C C; Isar, P G; Jacon, P; Kalekin, O; Kosyra, R; Kranich, D; Laatiaoui, M; Laille, A; Lenisa, T; Liebing, P; Lindfors, E; Lombardi, S; Longo, F; López, J; López, M; Lorenz, E; Lucarelli, F; Majumdar, P; Maneva, G; Mannheim, K; Mansutti, O; Mariotti, M; Martínez, M; Mase, K; Mazin, D; Merck, C; Meucci, M; Meyer, M; Miranda, J M; Mirzoyan, R; Mizobuchi, S; Moralejo, A; Nilsson, K; Oña-Wilhelmi, E; Orduña, R; Otte, N; Oya, I; Paneque, D; Paoletti, R; Paredes, J M; Pasanen, M; Pascoli, D; Pauss, F; Pavel, N; Pegna, R; Persic, M; Peruzzo, L; Piccioli, A; Poller, M; Pooley, G; Prandini, E; Raymers, A; Rhode, W; Ribó, M; Rico, J; Riegel, B; Rissi, M; Robert, A; Romero, G E; Rügamer, S; Saggion, A; Sánchez, A; Sartori, P; Scalzotto, V; Scapin, V; Schmitt, R; Schweizer, T; Shayduk, M; Shinozaki, K; Shore, S N; Sidro, N; Sillanpää, A; Sobczynska, D; Stamerra, A; Stark, L S; Takalo, L; Temnikov, P; Tescaro, D; Teshima, M; Tonello, N; Torres, A; Torres, D F; Turini, N; Vankov, H; Vitale, V; Wagner, R M; Wibig, T; Wittek, W; Zanin, R; Zapatero, J

    2006-06-23

    Microquasars are binary star systems with relativistic radio-emitting jets. They are potential sources of cosmic rays and can be used to elucidate the physics of relativistic jets. We report the detection of variable gamma-ray emission above 100 gigaelectron volts from the microquasar LS I 61 + 303. Six orbital cycles were recorded. Several detections occur at a similar orbital phase, which suggests that the emission is periodic. The strongest gamma-ray emission is not observed when the two stars are closest to one another, implying a strong orbital modulation of the emission or absorption processes. PMID:16709745

  5. Probability 1/e

    Science.gov (United States)

    Koo, Reginald; Jones, Martin L.

    2011-01-01

    Quite a number of interesting problems in probability feature an event with probability equal to 1/e. This article discusses three such problems and attempts to explain why this probability occurs with such frequency.

  6. Main: 1E1E [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E1E トウモロコシ Corn Zea mays L. Beta-Glucosidase, Chloroplast Precursor Name=Glu1; Zea...TDDAYASQEVNGPDGKPIGPPMGNPWIYMYPEGLKDLLMIMKNKYGNPPIYITENGIGDVDTKETPLPMEAALNDYKRLDYIQRHIATLKESIDLGSNVQGYFAWSLLDNFEWFAGFTERYGIVYVDRNNNCTRYMKESAKWLKEFNTAKKPSKKILTPA corn_1E1E.jpg ...

  7. A time dependent search for neutrino emission from micro-quasars with the ANTARES telescope

    International Nuclear Information System (INIS)

    The ANTARES collaboration has successfully built, deployed and is currently operating an underwater Cherenkov detector dedicated to high energy neutrino astronomy. The primary aim of the experiment is to detect cosmic sources of neutrinos in order to reveal the production sites of cosmic rays. Among the sources likely to be significant sources of neutrinos are those accelerating relativistic jets, like gamma ray bursts, active galactic nuclei and micro-quasars. Micro-quasars are binary systems formed by a compact object accreting mass from a companion star. The mass transfer causes the emission of X-rays, whereas the onset of magnetic forces in the accreting plasma can cause the acceleration of relativistic jets, which are observed by radio telescopes via their non-thermal synchrotron emission. In some systems, a correlation between X-ray and radio light curves indicates an interplay between accretion and ejection respectively. Some micro-quasars are also high energy and very high energy gamma ray emitters. In this thesis, a time dependent search for neutrino emission from micro-quasars was performed with a multi-messenger approach (photon/neutrino). The data from the X-ray monitors RXTE/ASM and SWIFT/BAT, and the gamma-ray telescope FERMI/LAT were used to select transient events in which the source was supposed to accelerate relativistic jets. The restriction of the analysis to the ejection periods allows a drastic reduction of atmospheric muon and neutrino background, and thus to increase the chances of a discovery. The search was performed with the ANTARES data taken between 2007 and 2010. Statistical analysis was carried out using an un-binned likelihood method based on a likelihood ratio test. The cuts for the event selection were optimized in order to maximize the chance of a discovery. As no neutrino signal was observed in correlation with these micro-quasars, upper limits on the neutrino fluxes of the micro-quasars under study were calculated and compared

  8. Modulated high-energy gamma-ray emission from the microquasar Cygnus X-3.

    Science.gov (United States)

    Abdo, A A; Ackermann, M; Ajello, M; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Baughman, B M; Bechtol, K; Bellazzini, R; Berenji, B; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Brez, A; Brigida, M; Bruel, P; Burnett, T H; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cecchi, C; Celik, O; Chaty, S; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Cominsky, L R; Conrad, J; Corbel, S; Corbet, R; Dermer, C D; de Palma, F; Digel, S W; do Couto e Silva, E; Drell, P S; Dubois, R; Dubus, G; Dumora, D; Farnier, C; Favuzzi, C; Fegan, S J; Focke, W B; Fortin, P; Frailis, M; Fusco, P; Gargano, F; Gehrels, N; Germani, S; Giavitto, G; Giebels, B; Giglietto, N; Giordano, F; Glanzman, T; Godfrey, G; Grenier, I A; Grondin, M-H; Grove, J E; Guillemot, L; Guiriec, S; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hill, A B; Hjalmarsdotter, L; Horan, D; Hughes, R E; Jackson, M S; Jóhannesson, G; Johnson, A S; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kawai, N; Kerr, M; Knödlseder, J; Kocian, M L; Koerding, E; Kuss, M; Lande, J; Latronico, L; Lemoine-Goumard, M; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Marchand, L; Marelli, M; Max-Moerbeck, W; Mazziotta, M N; McColl, N; McEnery, J E; Meurer, C; Michelson, P F; Migliari, S; Mitthumsiri, W; Mizuno, T; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Omodei, N; Ong, R A; Ormes, J F; Paneque, D; Parent, D; Pelassa, V; Pepe, M; Pesce-Rollins, M; Piron, F; Pooley, G; Porter, T A; Pottschmidt, K; Rainò, S; Rando, R; Ray, P S; Razzano, M; Rea, N; Readhead, A; Reimer, A; Reimer, O; Richards, J L; Rochester, L S; Rodriguez, J; Rodriguez, A Y; Romani, R W; Ryde, F; Sadrozinski, H F-W; Sander, A; Saz Parkinson, P M; Sgrò, C; Siskind, E J; Smith, D A; Smith, P D; Spinelli, P; Starck, J-L; Stevenson, M; Strickman, M S; Suson, D J; Takahashi, H; Tanaka, T; Thayer, J B; Thompson, D J; Tibaldo, L; Tomsick, J A; Torres, D F; Tosti, G; Tramacere, A; Uchiyama, Y; Usher, T L; Vasileiou, V; Vilchez, N; Vitale, V; Waite, A P; Wang, P; Wilms, J; Winer, B L; Wood, K S; Ylinen, T; Ziegler, M

    2009-12-11

    Microquasars are accreting black holes or neutron stars in binary systems with associated relativistic jets. Despite their frequent outburst activity, they have never been unambiguously detected emitting high-energy gamma rays. The Fermi Large Area Telescope (LAT) has detected a variable high-energy source coinciding with the position of the x-ray binary and microquasar Cygnus X-3. Its identification with Cygnus X-3 is secured by the detection of its orbital period in gamma rays, as well as the correlation of the LAT flux with radio emission from the relativistic jets of Cygnus X-3. The gamma-ray emission probably originates from within the binary system, opening new areas in which to study the formation of relativistic jets. PMID:19965378

  9. Non-linear variability in microquasars in relation with the winds from their accretion disks

    CERN Document Server

    Janiuk, Agnieszka; Sukova, Petra; Capitanio, Fiamma; Bianchi, Stefano; Kowalski, Wojtek

    2016-01-01

    The microquasar IGR J17091, which is the recently discovered analogue of the well known source GRS 1915+105, exhibits quasi-periodic outbursts, with a period of 5-70 seconds, and regular amplitudes, referred to as "heartbeat state". We argue that these states are plausibly explained by accretion disk instability, driven by the dominant radiation pressure. Using our GLobal Accretion DIsk Simulation hydrodynamical code, we model these outbursts quantitatively. We also find a correlation between the presence of massive outflows launched from the accretion disk and the stabilization of its oscillations. We verify the theoretical predictions with the available timing and spectral observations. Furthermore, we postulate that the underlying non-linear differential equations that govern the evolution of an accretion disk are responsible for the variability pattern of several other microquasars, including XTE J1550-564, GX 339-4, and GRO J1655-40. This is based on the signatures of deterministic chaos in the observed ...

  10. A Search for Time Dependent Neutrino Emission from Microquasars with the ANTARES Telescope

    CERN Document Server

    Adrián-Martínez, S; André, M; Anghinolfi, M; Anton, G; Ardid, M; Astraatmadja, T; Aubert, J -J; Baret, B; Barrios, J; Basa, S; Bertin, V; Biagi, S; Bigongiari, C; Bogazzi, C; Bouhou, B; Bouwhuis, M C; Brunner, J; Busto, J; Capone, A; Caramete, L; Cârloganu, C; Carr, J; Cecchini, S; Charif, Z; Charvis, P; Chiarusi, T; Circella, M; Coniglione, R; Core, L; Costantini, H; Coyle, P; Creusot, A; De Rosa, G; Dekeyser, I; Deschamps, A; De Bonis, G; Distefano, C; Donzaud, C; Dornic, D; Dorosti, Q; Drouhin, D; Dumas, A; Eberl, T; Elsässer, D; Emanuele, U; Enzenhöfer, A; Ernenwein, J -P; Escoffier, S; Fehn, K; Felis, I; Fermani, P; Folger, F; Fusco, L A; Galatà, S; Gay, P; Geißelsöder, S; Geyer, K; Giordano, V; Gleixner, A; Gómez-González, J P; Graf, K; Guillard, G; van Haren, H; Heijboer, A J; Hello, Y; Hernández-Rey, J J; Herold, B; Hößl, J; Hofestädt, J; James, C W; de Jong, M; Kadler, M; Kalekin, O; Kappes, A; Katz, U; Kooijman, P; Kouchner, A; Kreykenbohm, I; Kulikovskiy, V; Lahmann, R; Lambard, E; Lambard, G; Larosa, G; Lattuada, D; Lefèvre, D; Leonora, E; Loehner, H; Loucatos, S; Mangano, S; Marcelin, M; Margiotta, A; Martínez-Mora, J A; Martini, S; Mathieu, A; Michael, T; Migliozzi, P; Montaruli, T; Müller, C; Neff, M; Nezri, E; Palioselitis, D; Păvălaş, G E; Perrina, C; Piattelli, P; Popa, V; Pradier, T; Racca, C; Riccobene, G; Richter, R; Rivière, C; Robert, A; Roensch, K; Rostovtsev, A; Salda\; Samtleben, D F E; Sánchez-Losa, A; Sanguineti, M; Sapienza, P; Schmid, J; Schnabel, J; Schulte, S; Schüssler, F; Seitz, T; Sieger, C; Spies, A; Spurio, M; Steijger, J J M; Stolarczyk, T; Taiuti, M; Tamburini, C; Tayalati, Y; Trovato, A; Vallage, B; Vallée, C; Van Elewyck, V; Vernin, P; Visser, E; Vivolo, D; Wagner, S; Wilms, J; de Wolf, E; Yatkin, K; Yepes, H; Zornoza, J D; Zúñiga, J

    2014-01-01

    Results are presented on a search for neutrino emission from a sample of six microquasars, based on the data collected by the ANTARES neutrino telescope between 2007 and 2010. By means of appropriate time cuts, the neutrino search has been restricted to the periods when the acceleration of relativistic jets was taking place at the microquasars under study. The time cuts have been chosen using the information from the X-ray telescopes RXTE/ASM and Swift/BAT, and, in one case, the gamma-ray telescope Fermi/LAT. Since none of the searches has produced a statistically significant signal, upper limits on the neutrino fluences are derived and compared to the predictions from theoretical models.

  11. Modulated High-Energy Gamma-Ray Emission from the Micro-quasar Cygnus X-3

    International Nuclear Information System (INIS)

    Micro-quasars are accreting black holes or neutron stars in binary systems with associated relativistic jets. Despite their frequent outburst activity, they have never been unambiguously detected emitting high-energy gamma rays. The Fermi Large Area Telescope (LAT) has detected a variable high-energy source coinciding with the position of the x-ray binary and micro-quasar Cygnus X-3. Its identification with Cygnus X-3 is secured by the detection of its orbital period in gamma rays, as well as the correlation of the LAT flux with radio emission from the relativistic jets of Cygnus X-3. The gamma-ray emission probably originates from within the binary system, opening new areas in which to study the formation of relativistic jets. (authors)

  12. Accretion disk winds as the jet suppression mechanism in the microquasar GRS 1915+105.

    Science.gov (United States)

    Neilsen, Joseph; Lee, Julia C

    2009-03-26

    Stellar-mass black holes with relativistic jets, also known as microquasars, mimic the behaviour of quasars and active galactic nuclei. Because timescales around stellar-mass black holes are orders of magnitude smaller than those around more distant supermassive black holes, microquasars are ideal nearby 'laboratories' for studying the evolution of accretion disks and jet formation in black-hole systems. Whereas studies of black holes have revealed a complex array of accretion activity, the mechanisms that trigger and suppress jet formation remain a mystery. Here we report the presence of a broad emission line in the faint, hard states and narrow absorption lines in the bright, soft states of the microquasar GRS 1915+105. ('Hard' and 'soft' denote the character of the emitted X-rays.) Because the hard states exhibit prominent radio jets, we argue that the broad emission line arises when the jet illuminates the inner accretion disk. The jet is weak or absent during the soft states, and we show that the absorption lines originate when the powerful radiation field around the black hole drives a hot wind off the accretion disk. Our analysis shows that this wind carries enough mass away from the disk to halt the flow of matter into the radio jet. PMID:19325629

  13. Time-Dependent Synchrotron and Compton Spectra from Jets of Microquasars

    CERN Document Server

    Gupta, S; Dermer, C D; Boettcher, Markus; Dermer, Charles D.; Gupta, Swati

    2006-01-01

    Jet models for the high-energy emission of Galactic X-ray binary sources have regained significant interest with detailed spectral and timing studies of the X-ray emission from microquasars, the recent detection by the HESS collaboration of very-high-energy gamma-rays from the microquasar LS~5039, and the earlier suggestion of jet models for ultraluminous X-ray sources observed in many nearby galaxies. Here we study the synchrotron and Compton signatures of time-dependent electron injection and acceleration, adiabatic and radiative cooling, and different jet geometries in the jets of Galactic microquasars. Synchrotron, synchrotron-self-Compton, and external-Compton radiation processes with soft photons provided by the companion star and the accretion disk are treated. An analytical solution is presented to the electron kinetic equation for general power-law geometries of the jets for Compton scattering in the Thomson regime. We pay particular attention to predictions concerning the rapid flux and spectral var...

  14. New evidence on the origin of the microquasar GRO J1655-40

    CERN Document Server

    Combi, J A; Mirabel, I F

    2007-01-01

    Aims. Motivated by the new determination of the distance to the microquasar GRO J1655-40 by Foellmi et al. (2006), we conduct a detailed study of the distribution of the atomic and molecular gas, and dust around the open cluster NGC 6242, the possible birth place of the microquasar. The proximity and relative height of the cluster on the galactic disk provides a unique opportunity to study SNR evolution and its possible physical link with microquasar formation. Methods. We search in the interstellar atomic and molecular gas around NGC 6242 for traces that may have been left from a supernova explosion associated to the formation of the black hole in GRO J1655-40. Furthermore, the 60/100 mu IR color is used as a tracer of shocked-heated dust. Results. At the kinematical distance of the cluster the observations have revealed the existence of a HI hole of 1.5*1.5 degrees in diameter and compressed CO material acumulated along the south-eastern internal border of the HI cavity. In this same area, we found extended...

  15. Dynamical and radiative simulations of γ-ray jets in microquasars

    Science.gov (United States)

    Smponias, T.; Kosmas, T. S.

    2014-02-01

    The emission of γ-rays in jets emanating from the vicinity of collapsed stellar remnants, in binary systems known as microquasars, is investigated using a three-dimensional relativistic hydrocode (PLUTO), in combination with two in-house radiative transfer codes. Even though a great number of stellar systems may be addressed by such models, we restrict ourselves to the concrete example of the SS433 X-ray binary, the only microquasar with a definite hadronic content in its jets, as verified from spectral line observations. A variety of system configurations have been examined, by employing a hadron-based emission mechanism. The dependence of the γ-ray emissions on certain dynamical source properties, such as the hydrodynamic parameters of the mass-flow density, the gas-pressure and the temperature of the ejected matter, is simulated. Radiative properties, especially the assumed high-energy proton population inside the jet plasma, and its effect on the calculated emission, are also examined. Two sets of initial conditions of the chosen microquasar are employed, in order to cover different scenarios pertaining to the system under consideration.

  16. The role of fast magnetic reconnection in acceleration zones of microquasars and AGNs

    CERN Document Server

    Kadowaki, L H S

    2013-01-01

    Fast magnetic reconnection events can be a very powerful mechanism operating at the jet launching region of microquasars and AGNs. We have recently found that the power released by reconnection between the magnetic field lines of the coronal inner disk region and the lines anchored into the black hole is able to accelerate relativistic particles through a first-order Fermi process and produce the observed radio luminosity from both microquasars and low luminous AGNs (LLAGNs). We also found that the observed correlation between the radio luminosity and the mass of these sources, spanning 10^9 orders of magnitude in mass, is naturally explained by this process. In this work, assuming that the gamma-ray emission is probably originated in the same acceleration zones that produce the radio emission, we have applied the scenario above to investigate the origin of the high energy outcomes from an extensive number of sources including high (HLAGNs) and LLAGNs, microquasars and GRBs. We find correlation of our model w...

  17. JET TRAILS AND MACH CONES: THE INTERACTION OF MICROQUASARS WITH THE INTERSTELLAR MEDIUM

    International Nuclear Information System (INIS)

    A subset of microquasars exhibits high peculiar velocity with respect to the local standard of rest due to the kicks they receive when being born in supernovae. The interaction between the radio plasma released by microquasar jets from such high-velocity binaries with the interstellar medium must lead to the production of trails and bow shocks similar to what is observed in narrow-angle tailed radio galaxies and pulsar wind nebulae. We present a set of numerical simulations of this interaction that illuminate the long-term dynamical evolution and the observational properties of these microquasar bow-shock nebulae and trails. We find that this interaction always produces a structure that consists of a bow shock, a trailing neck, and an expanding bubble. Using our simulations to model emission, we predict that the shock surrounding the bubble and the neck should be visible in Hα emission, the interior of the bubble should be visible in synchrotron radio emission, and only the bow shock is likely to be detectable in X-ray emission. We construct an analytic model for the evolution of the neck and bubble shape and compare this model with observations of the X-ray binary SAX J1712.6-3739.

  18. An unusual timing and spectral state of a black hole microquasar XTE J1550-564

    Institute of Scientific and Technical Information of China (English)

    Ying-Kang Jin; Shuang-Nan Zhang; Ti-Pei Li

    2009-01-01

    An unusual timing and spectral state of a black hole microquasar XTE J1550-564 observed with RXTE is analyzed. Millisecond variabilities are found, which are significantly shorter than the minimum possible time scale in the light curves of black hole binaries, as suggested by Sunyaev & Revnivtsev (2000). The X-ray spectral fitting result indicates that there is an unusual soft component in the spectrum, which may be responsible for the millisecond variabilities. The millisecond variabilities as well as the unusual soft spectral component should be produced from some small, but independent active regions in the accretion disk.

  19. Chandra-ASCA-RXTE observations of the micro-quasar GRS 1915+105

    CERN Document Server

    Lee, J C; Reynolds, C S; Fabian, A C; Blackman, E G

    2000-01-01

    A Chandra AO1 30ks HETGS observation of the X-ray transient micro-quasar GRS 1915+105 reveals absorption edges and faint line emission over the HETG energy range. We find from a preliminary analysis evidence for prominent neutral K edges associated with iron, silicon, magnesium, and tentatively sulphur. The column densities assuming solar abundances are consistent with ~ few x $10^{22} cm^{-2}$ in excess of the Galactic value, and may point to surrounding cold material associated with GRS 1915+105. Neutral Fe K$\\alpha$ emission, and ionized absorption from Fe XXV and Fe XXVI are resolved. We limit our discussion to the Chandra results.

  20. Multi-wavelength INTEGRAL NEtwork (MINE) observations of the microquasar GRS 1915+105

    CERN Document Server

    Fuchs, Y; Shaw, S E; Kretschmar, P; Ribó, M; Chaty, S; Mirabel, I F; Dhawan, V; Pooley, G G; Brown, I; Spencer, R; Hannikainen, D C

    2004-01-01

    We present the international collaboration MINE (Multi-lambda Integral NEtwork) aimed at conducting multi-wavelength observations of X-ray binaries and microquasars simultaneously with the INTEGRAL gamma-ray satellite. We will focus on the 2003 March-April campaign of observations of the peculiar microquasar GRS 1915+105 gathering radio, IR and X-ray data. The source was observed 3 times in the plateau state, before and after a major radio and X-ray flare. It showed strong steady optically thick radio emission corresponding to powerful compact jets resolved in the radio images, bright near-infrared emission, a strong QPO at 2.5 Hz in the X-rays and a power law dominated spectrum without cutoff in the 3-300 keV range. We compare the different observations, their multi-wavelength light curves, including JEM-X, ISGRI and SPI, and the parameters deduced from fitting the spectra obtained with these instruments on board INTEGRAL.

  1. A LIKELY MICRO-QUASAR IN THE SHADOW OF M82 X-1

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Xiao-jie [Department of Astronomy and Key Laboratory of Modern Astronomy and Astrophysics, Nanjing University, Nanjing, 210093 (China); Liu, Jifeng; Liu, Jiren, E-mail: xuxj@nju.edu.cn, E-mail: jfliu@nao.cas.cn [Key Laboratory of Optical Astronomy, National Astronomical Observatories of China, 20 Datun Rd, Chaoyang, Beijing, 100012 (China)

    2015-02-01

    The ultra-luminous X-ray source M82 X-1 is one of the most promising intermediate mass black hole candidates in the local universe based on its high X-ray luminosities (10{sup 40}–10{sup 41} erg s{sup −1}) and quasi-periodic oscillations, and is possibly associated with a radio flare source. In this work, applying the sub-pixel technique to the 120 ks Chandra observation (ID: 10543) of M82 X-1, we split M82 X-1 into two sources separated by 1.″1. The secondary source is not detected in other M82 observations. The radio flare source is not found to associate with M82 X-1, but is instead associated with the nearby transient source S1 with an outburst luminosity of ∼10{sup 39} erg s{sup −1}. With X-ray outburst and radio flare activities analogous to the recently discovered micro-quasar in M31, S1 is likely to be a micro-quasar hidden in the shadow of M82 X-1.

  2. Dynamical and radiative simulations of $\\gamma$-ray jets in microquasars

    CERN Document Server

    Smponias, T

    2013-01-01

    The emission of $\\gamma$-rays in jets emanating from the vicinity of collapsed stellar remnants, in binary systems known as microquasars, is investigated using a three dimensional relativistic hydrocode (PLUTO), in combination with two in-house radiative transfer codes. Even though a great number of stellar systems may be addressed by such models, we restrict ourselves to the concrete example of the SS433 X-ray binary, the only microquasar with a definite hadronic content in its jets, as verified from spectral line observations. A variety of system configurations have been examined, by employing a hadron-based emission mechanism. The dependence of the $\\gamma$-ray emissions on certain dynamical source properties, such as the hydrodynamic parameters of the mass-flow density, the gas-pressure and the temperature of the ejected matter, is simulated. Radiative properties, especially the assumed high energy proton population inside the jet plasma, and its effect on the calculated emission, are also examined. Two s...

  3. Spectropolarimetric Study on Circumstellar Structure of Microquasar LS I +61deg 303

    CERN Document Server

    Nagae, O; Fukazawa, Y; Yamashita, T; Ohsugi, T; Uemura, M; Chiyonobu, S; Isogai, M; Cho, T; Suzuki, M; Okazaki, A; Okita, K; Yanagisawa, K; Nagae, Osamu; Kawabata, Koji S.; Fukazawa, Yasushi; Yamashita, Takuya; Ohsugi, Takashi; Uemura, Makoto; Chiyonobu, Shingo; Isogai, Mizuki; Cho, Toshinari; Suzuki, Masaaki; Okazaki, Akira; Okita, Kiichi; Yanagisawa, Kenshi

    2006-01-01

    We present optical linear spectropolarimetry of the microquasar LS I +61$^{\\circ}$ 303. The continuum emission is mildly polarized (up to 1.3 %) and shows almost no temporal change. We find a distinct change of polarization across the H$\\alpha$ emission line, indicating the existence of polarization component intrinsic to the microquasar. We estimate the interstellar polarization (ISP) component from polarization of the H$\\alpha$ line and derive the intrinsic polarization component. The wavelength dependence of the intrinsic component is well explained by Thomson scattering in equatorial disk of the Be-type mass donor. The position angle (PA) of the intrinsic polarization $\\sim 25^{\\circ}$ represents the rotational axis of the Be disk. This PA is nearly perpendicular to the PA of the radio jet found during quiescent phases. Assuming an orthogonal disk-jet geometry around the compact star, the rotational axis of the accretion disk is almost perpendicular to that of the Be disk. Moreover, according to the orbit...

  4. An unified model for superluminal motion and state transition on microquasars and quasars

    CERN Document Server

    Gong, B

    2006-01-01

    Superluminal motion has been interpreted as relativistically moving out flow. The increasing observations of such sources provide chance to investigate their mechanism in detail. This paper proposes that superluminal motion may be jet precession induced blob motion. This model can interpret a number of observational phenomena which are not well understood under the scenario of bulk motion, such as the absence of the receding blob after the outburst and the receding blob becomes brighter than the approaching one in XTE J1550-564 . Moreover the compton scattering of photos from a warped accretion disk may form a structured jet. And the precession of the structured jet may lead to the complicated state transitions observed in microquasars like GRS 1915+105. Applying to AGNs, the model may explain the scales of length and time of the phenomena proportioning to the mass of the black hole. The new model can be tested easily on microquasars, i.e., XTE J1550-564, on which the previous receding blob should move toward...

  5. IR spectra of the microquasar GRS 1915+105 during a low state

    CERN Document Server

    Harlaftis, E T; Castro-Tirado, A J

    2001-01-01

    There is controversy regarding the nature of the suspected donor star to the microquasar GRS 1915+105, and hence whether GRS 1915+105 is a high mass X-ray binary (HMXB) or a low-mass X-ray binary (LMXB). In order to clarify this issue, we obtained an infrared (J, H and K) spectrum of GRS 1915+105 in its low state which shows a steeper continuum than the prototype X-ray binary Sco X-1. We did not detect any HeII emission at 2.189 microns from GRS 1915+105 in our quiescent spectrum, indicating that the line is transient and is only observed during episodes of high X-ray activity. For our instrument configuration, there is no detection of the 12CO lines which are characteristic of late-type stars either in GRS1915+105 or Sco X-1.

  6. Are gamma rays produced in the core region of microquasars and AGNs?

    Science.gov (United States)

    Khiali, Behrouz; de Gouveia Dal Pino, Elisabete; Sol, Helene; del Valle, Maria Victoria

    2015-08-01

    Cosmic Ray (CR) acceleration is still challenging in high energy astrophysics. A first-order Fermi mechanism within magnetic reconnection layers has been demonstrated to be a powerful CR accelerator in recent studies. In this work we have investigated this acceleration process in the nuclear region of radio-galaxies and microquasars and found that the very high energy (VHE) emission from these astrophysical sources may be originated in the nuclear region around the central black hole. We employed both lepontic and hadronic models to interpret the observed gamma emission resulting from interactions of accelerated particles by magnetic reconnection with the ambient radiation, magnetic and matter fields. We compared the acceleration rate with the proper cooling rates obtaining the maximum particle energy and then reconstructed the spectral energy distribution (SED) for a few galactic and extragalactic sources and found that the are consistent with the observations. Also this model naturally explains the fast time variability of the emission of these sources.

  7. Jet propulsion of wind ejecta from a major flare in the black hole microquasar SS433

    CERN Document Server

    Blundell, Katherine

    2011-01-01

    We present direct evidence, from Adaptive-Optics near-infra-red imaging, of the jets in the Galactic microquasar SS433 interacting with enhanced wind-outflow off the accretion disc that surrounds the black hole in this system. Radiant quantities of gas are transported significant distances away from the black hole approximately perpendicular to the accretion disc from which the wind emanates. We suggest that the material that comprised the resulting "bow-tie" structure is associated with a major flare that the system exhibited ten months prior to the observations. During this flare, excess matter was expelled by the accretion disc as an enhanced wind, which in turn is "snow-ploughed", or propelled, out by the much faster jets that move at approximately a quarter of the speed of light. Successive instances of such bow-ties may be responsible for the large-scale X-ray cones observed across the W50 nebula by ROSAT.

  8. MASTER optical polarization variability detection in the Microquasar V404 Cyg/GS2023+33

    CERN Document Server

    Lipunov, Vladimir M; Kornilov, V; Krushinskiy, V; Vlasenko, D; Tiurina, N; Balanutsa, P; Kuznetsov, A; Budnev, N; Gress, O; Tlatov, A; Lopez, R Rebolo; Serra-Ricart, M; Buckley, D A H; Israelian, G; Lodieu, N; Ivanov, K; Yazev, S; Sergienko, Yu; Gabovich, A; Yurkov, V; Levato, H; Saffe, C; Podesta, R; Mallamaci, C; Lopez, C

    2016-01-01

    On 2015 June 15 the Swift space observatory discovered that the Galactic black hole candidate V404 Cyg was undergoing another active X-ray phase, after 25 years of inactivity (Barthelmy et al. 2015). Twelve telescopes of the MASTER Global Robotic Net located at six sites across four continents were the first ground based observatories to start optical monitoring of the microquasar after its gamma-ray wakeup at 18h 34m 09s U.T. on 2015 June 15 (Lipunov et al. 2015). In this paper we report, for the first time, the discovery of variable optical linear polarization, changing by 4-6% over a timescale of approximately 1 h, on two different epochs. We can conclude that the additional variable polarization arisies from the relativistic jet generated by the black hole in V404Cyg. The polarization variability correlates with optical brightness changes, increasing when the flux decreases.

  9. Unveiling the high energy tail of 1E 1740.7-2942 with INTEGRAL

    CERN Document Server

    Bouchet, L; Jourdain, E; Roques, J P; Bazzano, A; De Cesare, G

    2008-01-01

    The microquasar 1E 1740.7-2942 is observed with Integral since Spring 2003. Here, we report on the source high energy behaviour by using the first three years of data collected with SPI and IBIS telescopes, taking advantage of the instruments complementarity. Light curves analysis showed two main states for 1E 1740.7-2942: the canonical low/hard state of black-hole candidates and a ``dim'' state, characterised by a ~ 20 times fainter emission, detected only below 50 keV and when summing more than 1Ms of data. For the first time the continuum of the low/hard state has been measured up to ~ 600 keV with a spectrum that is well represented by a thermal Comptonization plus an additional component necessary to fit the data above 200 keV. This high energy component could be related to non-thermal processes as already observed in other black-hole candidates. Alternatively, we show that a model composed by two thermal Comptonizations provides an equally representative description of the data: the temperature of the f...

  10. UNVEILING THE HIGH ENERGY TAIL OF 1E 1740.7-2942 WITH INTEGRAL

    International Nuclear Information System (INIS)

    The microquasar 1E 1740.7-2942 is observed with INTEGRAL since Spring 2003. Here, we report on the source high-energy behavior by using the first three years of data collected with SPI and IBIS telescopes, taking advantage of the instruments complementarity. Light curves analysis showed two main states for 1E 1740.7-2942: the canonical low/hard state of black hole candidates (BHCs) and a dimstate, characterized by an ∼20 times fainter emission, detected only below 50 keV and when summing more than 1 Ms of data. For the first time the continuum of the low/hard state has been measured up to ∼600 keV with a spectrum that is well represented by a thermal Comptonization plus an additional component necessary to fit the data above 200 keV. This high-energy component could be related to nonthermal processes as already observed in other BHCs. Alternatively, we show that a model composed of two thermal Comptonizations provides an equally representative description of the data: the temperature of the first population of electrons results as (kT e)1∼ 30 keV while the second, (kT e)2, is fixed at 100 keV. Finally, searching for 511 keV line showed no feature, either narrow or broad, transient or persistent.

  11. THE VARIABLE NEAR-INFRARED COUNTERPART OF THE MICROQUASAR GRS 1758–258

    Energy Technology Data Exchange (ETDEWEB)

    Luque-Escamilla, Pedro L. [Departamento de Ingeniería Mecánica y Minera, EPSJ, Universidad de Jaén, Campus Las Lagunillas s/n, A3-008, 23071 Jaén (Spain); Martí, Josep [Departamento de Física, EPSJ, Universidad de Jaén, Campus Las Lagunillas s/n, A3-420, 23071 Jaén (Spain); Muñoz-Arjonilla, Álvaro J., E-mail: peter@ujaen.es, E-mail: jmarti@ujaen.es, E-mail: ajmunoz@ujaen.es [Grupo de Investigación FQM-322, Universidad de Jaén, Campus Las Lagunillas s/n, A3-065, 23071 Jaén (Spain)

    2014-12-10

    We present a new study of the microquasar system GRS 1758–258 in the near-infrared domain based on archival observations with the Hubble Space Telescope and the NICMOS camera. In addition to confirming the near-infrared counterpart pointed out by Muñoz-Arjonilla et al., we show that this object displays significant photometric variability. From its average magnitudes, we also find that GRS 1758–258 fits well within the correlation between the optical/near-infrared and X-ray luminosity known to exist for low-mass, black-hole candidate X-ray binaries in a hard state. Moreover, the spectral energy distribution built using all radio, near-infrared, and X-ray data available closest in time to the NICMOS observations can be reasonably interpreted in terms of a self-absorbed radio jet and an irradiated accretion disk model around a stellar-mass black hole. All these facts match the expected behavior of a compact binary system and strengthen our confidence in the counterpart identification.

  12. Multifrequency Observations of the Galactic Microquasars GRS1915+105 and GROJ1655-40

    CERN Document Server

    Remillard, R A; McClintock, J E; Bailyn, C D; Orosz, J A; Greiner, J; Remillard, Ronald A.; Morgan, Edward H.; Clintock, Jeffrey E. Mc; Bailyn, Charles D.; Orosz, Jerome A.; Greiner, Jochen

    1998-01-01

    The two galactic `microquasars' with superluminal radio jets have been quite active during 1996, generatinga variety of studies involving both NASA and ground-based observatories. GRS~1915+105 has displayed dramatic accretion instability in observations with RXTE, revealing X-ray light curves and emission states unlike anything previously seen. Variable QPOs in the range of 0.07--10 Hz have been monitored with the capability to track the individual oscillations. The QPO amplitude is as high as 40% of the mean flux, while both amplitude and phase lag increase with photon energy. The results imply a direct link between the QPO mechanism and the origin of the energetic electrons believed to radiate the X-ray power-law component. GRS1915+105 also displays a transient yet stationary QPO at 67 Hz. The other source, GRO J1655-40, is an optically established black hole binary. Recent optical reports include an excellent model for the binary inclination and masses, while an optical precursor to the April 1996 X-ray ou...

  13. Disk-Jet Connection in the Microquasar GRS 1915+105 and IR and Radio Emission

    CERN Document Server

    Yadav, J S

    2001-01-01

    We present evidence of a direct accretion disk-jet connection in the Galactic microquasar GRS 1915+105 based on our analysis of RXTE/PCA data with a ``spike'' in X-ray light curves. We find that the radio emission increases as the hardness ratio increases during the low hard state. We suggest that the ``spike'' which separates the dips with hard and soft spectra marks the beginning of the burst phase when the luminosity of the soft X-rays (5-15 keV) increases by a large factor (~ 10). This produces a major ejection episode of the synchrotron - emitting plasma termed as ``baby jets'' which are associated with infrared (IR) and radio flares of about half an hour period widely reported in the literature. Subsequent short but frequent soft dips produce overlapping faint flares which result in an enhanced level of quasi-steady emission. We discuss the dissipation of accretion energy in the inner part of the disk in terms of a comptonising cloud and the escaping mass which produces synchrotron radiation. We discuss...

  14. Testing modified gravity and no-hair relations for the Kerr-Newman metric through quasiperiodic oscillations of galactic microquasars

    Science.gov (United States)

    Suvorov, Arthur George; Melatos, Andrew

    2016-01-01

    We construct multipole moments for stationary, asymptotically flat, spacetime solutions to higher-order curvature theories of gravity. The moments are defined using 3 +1 techniques involving timelike Killing vector constructions as in the classic papers by Geroch and Hansen. Using the fact that the Kerr-Newman metric is a vacuum solution to a particular class of f (R ) theories of gravity, we compute all its moments, and find that they admit recurrence relations similar to those for the Kerr solution in general relativity. It has been proposed previously that modeling the measured frequencies of quasiperiodic oscillations from galactic microquasars enables experimental tests of the no-hair theorem. We explore the possibility that, even if the no-hair relation is found to break down in the context of general relativity, there may be an f (R ) counterpart that is preserved. We apply the results to the microquasars GRS 1915 +105 and GRO J1655-40 using the diskoseismology and kinematic resonance models, and constrain the spins and "charges" of their black holes.

  15. Non-Markov statistical effects of X-ray emission intensity of the microquasar GRS 1915+105

    CERN Document Server

    Yulmetyev, R M; Khusnutdinov, R M; Panischev, O Y; Hänggi, P

    2006-01-01

    In this paper we develop the new approach in time series analysis with a variable time step and present the results of quantitative and qualitative estimation of randomness and regularity, and the study of non-Markovian effects of the X-ray emission intensity of the microquasar GRS 1915+105. Our estimation is based on the application of the theory of discrete non-Markovian stochastic processes and gives a wide set of quantitative characteristics and parameters of the studied system with a variable time step. This set reflects the change of the effects of randomness and regularity, the alternation of Markovian and non-Markovian processes in the initial time signals. Initially these characteristics were determined for the simple model systems constructed by means of a molecular dynamics method. Further the calculation of these parameters was executed for the X-ray emission intensity of the microquasar GRS 1915+105. We have developed a theoretical scheme for the detailed analysis of the time series with a variab...

  16. The effects of the stellar wind and orbital motion on the jets of high-mass microquasars

    Science.gov (United States)

    Bosch-Ramon, V.; Barkov, M. V.

    2016-05-01

    Context. High-mass microquasar jets propagate under the effect of the wind from the companion star, and the orbital motion of the binary system. The stellar wind and the orbit may be dominant factors determining the jet properties beyond the binary scales. Aims: This is an analytical study, performed to characterise the effects of the stellar wind and the orbital motion on the jet properties. Methods: Accounting for the wind thrust transferred to the jet, we derive analytical estimates to characterise the jet evolution under the impact of the stellar wind. We include the Coriolis force effect, induced by orbital motion and enhanced by the wind's presence. Large-scale evolution of the jet is sketched, accounting for wind-to-jet thrust transfer, total energy conservation, and wind-jet flow mixing. Results: If the angle of the wind-induced jet bending is larger than its half-opening angle, the following is expected: (i) a strong recollimation shock; (ii) bending against orbital motion, caused by Coriolis forces and enhanced by the wind presence; and (iii) non-ballistic helical propagation further away. Even if disrupted, the jet can re-accelerate due to ambient pressure gradients, but wind entrainment can weaken this acceleration. On large scales, the opening angle of the helical structure is determined by the wind-jet thrust relation, and the wind-loaded jet flow can be rather slow. Conclusions: The impact of stellar winds on high-mass microquasar jets can yield non-ballistic helical jet trajectories, jet partial disruption and wind mixing, shocks, and possibly non-thermal emission. Among other observational diagnostics, such as radiation variability at any band, the radio morphology on milliarcsecond scales can be informative on the wind-jet interaction.

  17. A search for very high-energy flares from the microquasars GRS 1915+105, Circinus X-1, and V4641 Sgr using contemporaneous H.E.S.S. and \\textit{RXTE} observations

    CERN Document Server

    Abdalla, H; Aharonian, F; Benkhali, F Ait; Akhperjanian, A G; Angüner, E O; Arrieta, M; Aubert, P; Backes, M; Balzer, A; Barnard, M; Becherini, Y; Tjus, J Becker; Berge, D; Bernhard, S; Bernlöhr, K; Birsin, E; Blackwell, R; Böttcher, M; Boisson, C; Bolmont, J; Bordas, P; Bregeon, J; Brun, F; Brun, P; Bryan, M; Bulik, T; Capasso, M; Carr, J; Casanova, S; Chadwick, P M; Chakraborty, N; Chalme-Calvet, R; Chaves, R C G; Chen, A; Chevalier, J; Chrétien, M; Colafrancesco, S; Cologna, G; Condon, B; Conrad, J; Couturier, C; Cui, Y; Davids, I D; Degrange, B; Deil, C; deWilt, P; Dickinson, H J; Djannati-Ataï, A; Domainko, W; Donath, A; Drury, L O'C; Dubus, G; Dutson, K; Dyks, J; Dyrda, M; Edwards, T; Egberts, K; Eger, P; Ernenwein, J -P; Eschbach, S; Farnier, C; Fegan, S; Fernandes, M V; Fiasson, A; Fontaine, G; Förster, A; Funk, S; Füßling, M; Gabici, S; Gajdus, M; Gallant, Y A; Garrigoux, T; Giavitto, G; Giebels, B; Glicenstein, J F; Gottschall, D; Goyal, A; Grondin, M -H; Grudzińska, M; Hadasch, D; Hahn, J; Hawkes, J; Heinzelmann, G; Henri, G; Hermann, G; Hervet, O; Hillert, A; Hinton, J A; Hofmann, W; Hoischen, C; Holler, M; Horns, D; Ivascenko, A; Jacholkowska, A; Jamrozy, M; Janiak, M; Jankowsky, D; Jankowsky, F; Jingo, M; Jogler, T; Jouvin, L; Jung-Richardt, I; Kastendieck, M A; Katarzyński, K; Katz, U; Kerszberg, D; Khélifi, B; Kieffer, M; King, J; Klepser, S; Klochkov, D; Kluźniak, W; Kolitzus, D; Komin, Nu; Kosack, K; Krakau, S; Kraus, M; Krayzel, F; Krüger, P P; Laffon, H; Lamanna, G; Lau, J; -P., J; Lefaucheur, J; Lefranc, V; Lemière, A; Lemoine-Goumard, M; Lenain, J -P; Leser, E; Lohse, T; Lorentz, M; Liu, R; Lypova, I; Marandon, V; Marcowith, A; Mariaud, C; Marx, R; Maurin, G; Maxted, N; Mayer, M; Meintjes, P J; Menzler, U; Meyer, M; Mitchell, A M W; Moderski, R; Mohamed, M; Morå, K; Moulin, E; Murach, T; de Naurois, M; Niederwanger, F; Niemiec, J; Oakes, L; Odaka, H; Öttl, S; Ohm, S; Ostrowski, M; Oya, I; Padovani, M; Panter, M; Parsons, R D; Arribas, M Paz; Pekeur, N W; Pelletier, G; Petrucci, P -O; Peyaud, B; Pita, S; Poon, H; Prokhorov, D; Prokoph, H; Pühlhofer, G; Punch, M; Quirrenbach, A; Raab, S; Reimer, A; Reimer, O; Renaud, M; Reyes, R de los; Rieger, F; Romoli, C; Rosier-Lees, S; Rowell, G; Rudak, B; Rulten, C B; Sahakian, V; Salek, D; Sanchez, D A; Santangelo, A; Sasaki, M; Schlickeiser, R; Schüssler, F; Schulz, A; Schwanke, U; Schwemmer, S; Seyffert, A S; Shafi, N; Shilon, I; Simoni, R; Sol, H; Spanier, F; Spengler, G; Spies, F; Stawarz, Ł; Steenkamp, R; Stegmann, C; Stinzing, F; Stycz, K; Sushch, I; Tavernet, J -P; Tavernier, T; Taylor, A M; Terrier, R; Tluczykont, M; Trichard, C; Tuffs, R; van der Walt, J; van Eldik, C; van Soelen, B; Vasileiadis, G; Veh, J; Venter, C; Viana, A; Vincent, P; Vink, J; Voisin, F; Völk, H J; Vuillaume, T; Wadiasingh, Z; Wagner, S J; Wagner, P; Wagner, R M; White, R; Wierzcholska, A; Willmann, P; Wörnlein, A; Wouters, D; Yang, R; Zabalza, V; Zaborov, D; Zacharias, M; Zdziarski, A A; Zech, A; Zefi, F; Ziegler, A; Żywucka, N

    2016-01-01

    Microquasars are potential $\\gamma$-ray emitters. Indications of transient episodes of $\\gamma$-ray emission were recently reported in at least two systems: Cyg X-1 and Cyg X-3. The identification of additional $\\gamma$-ray-emitting microquasars is required to better understand how $\\gamma$-ray emission can be produced in these systems. Theoretical models have predicted very high-energy (VHE) $\\gamma$-ray emission from microquasars during periods of transient outburst. Observations reported herein were undertaken with the objective of observing a broadband flaring event in the $\\gamma$-ray and X-ray bands. Contemporaneous observations of three microquasars, GRS 1915+105, Circinus X-1, and V4641 Sgr, were obtained using the High Energy Spectroscopic System (H.E.S.S.) telescope array and the Rossi X-ray Timing Explorer (RXTE) satellite. X-ray analyses for each microquasar were performed and VHE $\\gamma$-ray upper limits from contemporaneous H.E.S.S. observations were derived. No significant $\\gamma$-ray signal ...

  18. The effects of the stellar wind and orbital motion on the jets of high-mass microquasars

    CERN Document Server

    Bosch-Ramon, V

    2016-01-01

    High-mass microquasar jets propagate under the effect of the wind from the companion star, and the orbital motion of the binary system. The stellar wind and the orbit may be dominant factors determining the jet properties beyond the binary scales.} An analytical study is performed to characterize the effects of the stellar wind and the orbital motion on the jet properties. Accounting for the wind thrust transferred to the jet, we derive analytical estimates to characterize the jet evolution under the impact of the stellar wind. We include the Coriolis force effect, induced by orbital motion and enhanced by the wind presence. Large-scale evolution of the jet is sketched accounting for wind-to-jet thrust transfer, total energy conservation, and wind-jet flow mixing. If the angle of the wind-induced jet bending is larger than its half-opening angle, the following is expected: (i) a strong recollimation shock; (ii) bending against orbital motion, caused by Coriolis forces and enhanced by the wind presence; and (i...

  19. Different Types of X-ray Variability Observed in Micro-Quasar GRS 1915+105 with the IXAE

    CERN Document Server

    Naik, S; Paul, B; Rao, A R; Yadav, J S; Seetha, S

    2001-01-01

    The galactic micro-quasar source GRS 1915+105 has been observed with the Indian X-ray Astronomy Experiment (IXAE) several times over a period extending from 1996 to 2000. The source has been observed in different luminosity states and exhibits a rich variety of random and regular X-ray variability over a wide range of time scales. It also shows a unique variability characteristic namely the occurrence of quasi-regular X-ray bursts with period ranging from 20 s to about 100 s which have slow rise and fast decay. The X-ray spectrum of these bursts is hardest near the end of decay. In the low-hard state and bright-soft state with rapid variability, the source exhibits quasi-periodic oscillations (QPOs) with variable frequency which is luminosity dependent. Regular X-ray intensity dips have been detected coincident with the occurrence of a giant radio outburst. The source made a transition from a low-state to a high-state in 1999 in less than a day and from a soft-bright state to a hard-low state in 2000 in less ...

  20. Infrared study of H1743-322 in outburst: a radio-quiet and NIR-dim microquasar

    CERN Document Server

    Chaty, S; Dubus, G

    2015-01-01

    The X-ray binary, black hole candidate, and microquasar H1743-322 exhibited a series of X-ray outbursts between 2003 and 2008. We took optical/infrared (OIR) observations with the ESO/NTT telescope during 3 of these outbursts (2003, 2004, and 2008), to study its spectral energy distribution (SED). We detect rapid flares of duration ~5 mn in the high time-resolution IR lightcurve. We identify H and He emission lines in the IR spectra, coming from the accretion disk. The IR SED exhibits the spectral index typically associated with the X-ray high, soft state in our observations taken during the 2003 and 2004 outbursts, while the index changes to one that is typical of the X-ray low, hard state during the 2008 outburst. During this last outburst, we detected a change of slope in the NIR spectrum between the J and Ks bands, where the JH part is characteristic of an optically thick disk emission, while the HKs part is typical of optically thin synchrotron emission. Furthermore, the comparison of our IR data with ra...

  1. GAMMA-RAY OBSERVATIONS OF THE MICROQUASARS CYGNUS X-1, CYGNUS X-3, GRS 1915+105, AND GX 339–4 WITH THE FERMI LARGE AREA TELESCOPE

    Energy Technology Data Exchange (ETDEWEB)

    Bodaghee, Arash; Tomsick, John A. [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720 (United States); Pottschmidt, Katja [CRESST and NASA Goddard Space Flight Center, Astrophysics Science Division, Code 661, Greenbelt, MD 20771 (United States); Rodriguez, Jérôme [Laboratoire AIM, CEA/IRFU, Université Paris Diderot, CNRS/INSU, CEA DSM/IRFU/SAp, Centre de Saclay, F-91191 Gif-sur-Yvette (France); Wilms, Jörn [Dr. Karl Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Sternwartstrasse 7, D-96049 Bamberg (Germany); Pooley, Guy G., E-mail: bodaghee@ssl.berkeley.edu [Mullard Radio Astronomy Observatory, Cavendish Laboratory, The University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

    2013-10-01

    Detecting gamma-rays from microquasars is a challenging but worthwhile endeavor for understanding particle acceleration and the jet mechanism and for constraining leptonic/hadronic emission models. We present results from a likelihood analysis on timescales of 1 day and 10 days of ∼4 yr worth of gamma-ray observations (0.1-10 GeV) by Fermi-LAT of Cyg X-1, Cyg X-3, GRS 1915+105, and GX 339–4. Our analysis reproduced all but one of the previous gamma-ray outbursts of Cyg X-3 as reported with Fermi or AGILE, plus five new days on which Cyg X-3 is detected at a significance of ∼5σ that are not reported in the literature. In addition, Cyg X-3 is significantly detected on 10 day timescales outside of known gamma-ray flaring epochs, which suggests that persistent gamma-ray emission from Cyg X-3 has been detected for the first time. For Cyg X-1 we find three low-significance excesses (∼3-4σ) on daily timescales that are contemporaneous with gamma-ray flares reported (also at low significance) by AGILE. Two other microquasars, GRS 1915+105 and GX 339–4, are not detected, and we derive 3σ upper limits of 2.3 × 10{sup –8} photons cm{sup –2} s{sup –1} and 1.6 × 10{sup –8} photons cm{sup –2} s{sup –1}, respectively, on the persistent flux in the 0.1-10 GeV range. These results enable us to define a list of the general conditions that are necessary for the detection of gamma-rays from microquasars.

  2. GAMMA-RAY OBSERVATIONS OF THE MICROQUASARS CYGNUS X-1, CYGNUS X-3, GRS 1915+105, AND GX 339–4 WITH THE FERMI LARGE AREA TELESCOPE

    International Nuclear Information System (INIS)

    Detecting gamma-rays from microquasars is a challenging but worthwhile endeavor for understanding particle acceleration and the jet mechanism and for constraining leptonic/hadronic emission models. We present results from a likelihood analysis on timescales of 1 day and 10 days of ∼4 yr worth of gamma-ray observations (0.1-10 GeV) by Fermi-LAT of Cyg X-1, Cyg X-3, GRS 1915+105, and GX 339–4. Our analysis reproduced all but one of the previous gamma-ray outbursts of Cyg X-3 as reported with Fermi or AGILE, plus five new days on which Cyg X-3 is detected at a significance of ∼5σ that are not reported in the literature. In addition, Cyg X-3 is significantly detected on 10 day timescales outside of known gamma-ray flaring epochs, which suggests that persistent gamma-ray emission from Cyg X-3 has been detected for the first time. For Cyg X-1 we find three low-significance excesses (∼3-4σ) on daily timescales that are contemporaneous with gamma-ray flares reported (also at low significance) by AGILE. Two other microquasars, GRS 1915+105 and GX 339–4, are not detected, and we derive 3σ upper limits of 2.3 × 10–8 photons cm–2 s–1 and 1.6 × 10–8 photons cm–2 s–1, respectively, on the persistent flux in the 0.1-10 GeV range. These results enable us to define a list of the general conditions that are necessary for the detection of gamma-rays from microquasars

  3. Joint H-alpha and X-Ray Observations of Massive X-Ray Binaries. II. The Be X-ray Binary and Microquasar LS I +61 303

    OpenAIRE

    Grundstrom, E. D.; Caballero-Nieves, S. M.; Gies, D. R.; Huang, W.; McSwain, M. V.; Rafter, S. E.; Riddle, R. L.; Williams, S. J.; Wingert, D. W.

    2006-01-01

    We present the results of an H-alpha monitoring campaign on the BeXRB and microquasar system LS I +61 303. We use radial velocity measurements of HeI lines in our spectra to re-evaluate the orbital elements and to better establish the time of periastron. We list equivalent widths and other parameters for the H-alpha emission line and discuss the orbital phase related variations observed. We call attention to a dramatic episode of emission weakening that occurred in less than a day that probab...

  4. A parallax distance to the microquasar GRS 1915+105 and a revised estimate of its black hole mass

    Energy Technology Data Exchange (ETDEWEB)

    Reid, M. J.; McClintock, J. E.; Steiner, J. F.; Narayan, R. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Steeghs, D. [Department of Physics, The University of Warwick, Coventry CV4 7AL (United Kingdom); Remillard, R. A. [MIT Kavli Institute for Astrophysics and Space Research, MIT, 70 Vassar Street, Cambridge, MA 02139 (United States); Dhawan, V., E-mail: mreid@cfa.harvard.edu [National Radio Astronomy Observatory, P.O. Box 0, Socorro, NM 87801 (United States)

    2014-11-20

    Using the Very Long Baseline Array, we have measured a trigonometric parallax for the microquasar GRS 1915+105, which contains a black hole and a K-giant companion. This yields a direct distance estimate of 8.6{sub −1.6}{sup +2.0} kpc and a revised estimate for the mass of the black hole of 12.4{sub −1.8}{sup +2.0} M {sub ☉}. GRS 1915+105 is at about the same distance as some H II regions and water masers associated with high-mass star formation in the Sagittarius spiral arm of the Galaxy. The absolute proper motion of GRS 1915+105 is –3.19 ± 0.03 mas yr{sup –1} and –6.24 ± 0.05 mas yr{sup –1} toward the east and north, respectively, which corresponds to a modest peculiar speed of 22 ± 24 km s{sup –1} at the parallax distance, suggesting that the binary did not receive a large velocity kick when the black hole formed. On one observational epoch, GRS 1915+105 displayed superluminal motion along the direction of its approaching jet. Considering previous observations of jet motions, the jet in GRS 1915+105 can be modeled with a jet inclination to the line of sight of 60° ± 5° and a variable flow speed between 0.65c and 0.81c, which possibly indicates deceleration of the jet at distances from the black hole ≳ 2000 AU. Finally, using our measurements of distance and estimates of black hole mass and inclination, we provisionally confirm our earlier result that the black hole is spinning very rapidly.

  5. A parallax distance to the microquasar GRS 1915+105 and a revised estimate of its black hole mass

    International Nuclear Information System (INIS)

    Using the Very Long Baseline Array, we have measured a trigonometric parallax for the microquasar GRS 1915+105, which contains a black hole and a K-giant companion. This yields a direct distance estimate of 8.6−1.6+2.0 kpc and a revised estimate for the mass of the black hole of 12.4−1.8+2.0 M ☉. GRS 1915+105 is at about the same distance as some H II regions and water masers associated with high-mass star formation in the Sagittarius spiral arm of the Galaxy. The absolute proper motion of GRS 1915+105 is –3.19 ± 0.03 mas yr–1 and –6.24 ± 0.05 mas yr–1 toward the east and north, respectively, which corresponds to a modest peculiar speed of 22 ± 24 km s–1 at the parallax distance, suggesting that the binary did not receive a large velocity kick when the black hole formed. On one observational epoch, GRS 1915+105 displayed superluminal motion along the direction of its approaching jet. Considering previous observations of jet motions, the jet in GRS 1915+105 can be modeled with a jet inclination to the line of sight of 60° ± 5° and a variable flow speed between 0.65c and 0.81c, which possibly indicates deceleration of the jet at distances from the black hole ≳ 2000 AU. Finally, using our measurements of distance and estimates of black hole mass and inclination, we provisionally confirm our earlier result that the black hole is spinning very rapidly.

  6. Testing modified gravity and no-hair relations for the Kerr-Newman metric through quasi-periodic oscillations of galactic microquasars

    CERN Document Server

    Suvorov, Arthur George

    2016-01-01

    We construct multipole moments for stationary, asymptotically flat, spacetime solutions to higher-order curvature theories of gravity. The moments are defined using $3+1$ techniques involving timelike Killing vector constructions as in the classic papers by Geroch and Hansen. Using the fact that the Kerr-Newman metric is a vacuum solution to a particular class of $f(R)$ theories of gravity, we compute all its moments, and find that they admit recurrence relations similar to those for the Kerr solution in general relativity. It has been proposed previously that modelling the measured frequencies of quasi-periodic oscillations from galactic microquasars enables experimental tests of the no-hair theorem. We explore the possibility that, even if the no-hair relation is found to break down in the context of general relativity, there may be an $f(R)$ counterpart that is preserved. We apply the results to the microquasars GRS $1915$+$105$ and GRO J$1655$-$40$ using the diskoseismology and kinematic resonance models,...

  7. Class 1E digital systems studies

    Energy Technology Data Exchange (ETDEWEB)

    Hecht, H.; Tai, A.T.; Tso, K.S. [SoHaR, Inc., Beverly Hills, CA (United States)

    1993-10-01

    This document is furnished as part of the effort to develop NRC Class 1E Digital Computer Systems Guidelines which is Task 8 of USAF Rome Laboratories Contract F30602-89-D-0100. The report addresses four major topics, namely, computer programming languages, software design and development, software testing and fault tolerance and fault avoidance. The topics are intended as stepping stones leading to a Draft Regulatory Guide document. As part of this task a small scale survey of software fault avoidance and fault tolerance practices was conducted among vendors of nuclear safety related systems and among agencies that develop software for other applications demanding very high reliability. The findings of the present report are in part based on the survey and in part on review of software literature relating to nuclear and other critical installations, as well as on the authors` experience in these areas.

  8. Class 1E digital systems studies

    International Nuclear Information System (INIS)

    This document is furnished as part of the effort to develop NRC Class 1E Digital Computer Systems Guidelines which is Task 8 of USAF Rome Laboratories Contract F30602-89-D-0100. The report addresses four major topics, namely, computer programming languages, software design and development, software testing and fault tolerance and fault avoidance. The topics are intended as stepping stones leading to a Draft Regulatory Guide document. As part of this task a small scale survey of software fault avoidance and fault tolerance practices was conducted among vendors of nuclear safety related systems and among agencies that develop software for other applications demanding very high reliability. The findings of the present report are in part based on the survey and in part on review of software literature relating to nuclear and other critical installations, as well as on the authors' experience in these areas

  9. Chandra Discovers the X-ray Signature of a Powerful Wind from a Galactic Microquasar

    Science.gov (United States)

    2000-11-01

    Wide Web, along with other information about the discovery, at http://www.astro.psu.edu/users/niel/cirx1/cirx1.html. A binary-star system 20,000 light years from Earth in the constellation of Circinus. Animation showing the strong variability over time of one of the P Cygni spectral lines seen by Chandra from Circinus X-1 (Click Image to View Animation) Credit: Niel Brandt and Norbert Schulz (Note: This animation is the same as the one referred to in the above paragraph) Atoms irradiated with energetic X-rays can emit as well as absorb them at specific wavelengths. Whether astronomers observe emission or absorption depends on the state and environment of the irradiated atoms, so these processes carry vital information about the emitting and absorbing material. Regarding the time-lapse movie, Schulz commented "You can see this profile flipping up and down between a strong emission line on the red side and a strong absorption line on the blue side. We don't yet fully understand what this means, but it does indicate the dynamic nature of this system. We see indications that sometimes either the emitting or the absorbing region gets obscured by matter so thick that not even X rays can penetrate it." The researchers say one reason their discovery that Circinus X-1 has a high-velocity wind is important is that this small two-star system now has striking similarities with a type of luminous active galaxy known as a broad-absorption-line quasar. Broad-absorption-line quasars are galaxies containing a violent centers powered by supermassive black holes. "This type of galaxy has an accretion disk circling its black hole plus very powerful winds created when radiation pushes material off of the disk and out into space," Brandt says. "The disk winds from broad-absorption-line quasars create P Cygni lines in the spectra of these objects. Circinus X-1, with the newly detected X-ray P Cygni profiles, appears in many ways to be a microscopic version of a broad-absorption-line quasar

  10. Main: 1E4L [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E4L トウモロコシ Corn Zea mays L. Beta-Glucosidase, Chloroplast Precursor Name=Glu1; Zea...MKNKYGNPPIYITENGIGDVDTKETPLPMEAALNDYKRLDYIQRHIATLKESIDLGSNVQGYFAWSLLDNFEWFAGFTERYGIVYVDRNNNCTRYMKESAKWLKEFNTAKKPSKKILTPA corn_1E4L.jpg ...

  11. Main: 1E1F [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E1F トウモロコシ Corn Zea mays L. Beta-Glucosidase, Chloroplast Precursor Name=Glu1; Zea...QRHIATLKESIDLGSNVQGYFAWSLLDNFEWFAGFTERYGIVYVDRNNNCTRYMKESAKWLKEFNTAKKPSKKILTPA corn_1E1F.jpg ...

  12. Gamma-ray observations of the microquasars Cygnus X-1, Cygnus X-3, GRS 1915+105, and GX 339-4 with the Fermi Large Area Telescope

    CERN Document Server

    Bodaghee, Arash; Pottschmidt, Katja; Rodriguez, Jerome; Wilms, Joern; Pooley, Guy G

    2013-01-01

    Detecting gamma-rays from microquasars is a challenging but worthwhile endeavor for understanding particle acceleration, the jet mechanism, and for constraining leptonic/hadronic emission models. We present results from a likelihood analysis on timescales of 1 d and 10 d of ~4 years worth of gamma-ray observations (0.1-10 GeV) by Fermi-LAT of Cyg X-1, Cyg X-3, GRS 1915+105, and GX 339-4. Our analysis reproduced all but one of the previous gamma-ray outbursts of Cyg X-3 as reported with Fermi or AGILE, plus 5 new days on which Cyg X-3 is detected at a significance of ~5-sigma that are not reported in the literature. In addition, Cyg X-3 is significantly detected on 10-d timescales outside of known gamma-ray flaring epochs which suggests that persistent gamma-ray emission from Cyg X-3 has been detected for the first time. For Cyg X-1, we find three low significance excesses (~3-4-sigma) on daily timescales that are contemporaneous with gamma-ray flares reported (also at low significance) by AGILE. Two other mic...

  13. A Relativistic Fe K-alpha Emission Line in the Intermediate Luminosity BeppoSAX Spectrum of the Galactic Microquasar V4641 Sgr

    CERN Document Server

    Miller, J M; in 't Zand, J J M; Reynolds, C S; Wijnands, R; Nowak, M A; Lewin, W H G

    2002-01-01

    Broad Fe K-alpha emission lines have recently been reported in a number of Galactic black holes. Such lines are useful accretion flow diagnostics because they may be produced at the inner accretion disk and shaped by relativistic effects, but in general they have only been observed at luminosities of L_X = 10^(37-38) erg/s in soft X-rays. The Galactic microquasar V4641 Sgr -- widely known for its 12.2 Crab (1.5-12 keV) outburst in 1999 September -- displayed low-level activity in 1999 March. BeppoSAX observed the source in this state and Fe K-alpha line emission was found (in 't Zand et al. 2000). In re-analyzing these data, we find strong evidence that the Fe K-alpha line profile is broadened. For the most likely values of the source distance and black hole mass measured by Orosz et al. (2001), our fits to the total spectrum indicate that the source was observed at a luminosity of L_X = 1.9 (+1.0, -0.8) * 10^(36) erg/s (2-10 keV), or L_(2-10)/L_(Eddington) = 1.8 (+0.9, -0.8) * 10^(-3). Advection-dominated ac...

  14. Main: 1E6B [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E6B シロイヌナズナ Arabidopsis Arabidopsis thaliana (L.) Heynh. Glutathione S-Transferase Zeta- ... : Characterisation Of A Gst With Novel Active-Site Architecture ... And A Putative Role In Tyrosine Catabolism. J.Mol. ...

  15. Security 1E10 anti-idiotypic vaccine in patients with tumors of different locations

    Directory of Open Access Journals (Sweden)

    Carmen Viada

    2016-02-01

    Full Text Available Cancer is a leading cause of death in Cuba and the world. Lung cancer is the leading cause of death, breast cancer is the second leading cause of death and colorectal cancer is the third leading cause of death. The 1E10 anti-idiotype vaccine is a new immunotherapeutic agent, registered for lung cancer by the Center for Molecular Immunology (CIM. You want to evaluate the safety of this vaccine in the treatment of various cancer sites. To determine the safety adverse events occurred in six clinical trials (one stage I lung, 3 phase II in breast, colon and lung, 1 phase II-III and program expanded use, both in lung were evaluated. 656 patients were studied. Demographic variables, the characteristics of the disease and adverse events were measured. The studies were balanced with respect to baseline characteristics. The most common adverse events were local reactions associated with 1E10 anti-idiotype vaccine and systemic reactions of mild or moderate intensity that were not related to the administration of the vaccine under study. The 1E10 anti-idiotype vaccine is safe for the low frequency and intensity of adverse events reported.

  16. Total qualification of class 1E electric equipment

    International Nuclear Information System (INIS)

    For nuclear power plant projects in France, Framatome and its partners Electricite de France (EDF) and the Commissariat a l'Energie Atomique (CEA) have responded to the present qualification context by implementing a wide-ranging qualification program to acquire significant organizational and practical experience. The following sections detail Framatome's approach to the activities of an organization mandated to provide a complete spectrum of qualification services. Thorough implementation of a Class 1E electric equipment qualification program by the competent organization or qualifier entails completion of three consecutive steps: 1) program preparation, 2) program implementation, and 3) analysis of test results and conclusion. The qualifier assumes extensive responsibility for each of these steps. The following sections present test facilities used in France to conduct a total qualification program for Class 1E electric equipment

  17. Proper Motion and Timing of Two Unusual Pulsars: Calvera and 1E 1207.4-5209

    CERN Document Server

    Halpern, J P

    2015-01-01

    Using pairs of images from the Chandra High-Resolution Camera we examine the proper motion of the central compact object (CCO) 1E 1207.4-5209 in the supernova remnant (SNR) PKS 1209-51/52, and the unusual pulsar Calvera that is possibly a CCO descendant. For 1E 1207.4-5209, an insignificant proper motion of 15+/-7 mas/yr is measured, corresponding to a corrected tangential velocity of <180 km/s at the distance of 2 kpc. This proves that the previously noted large offset of the pulsar from the apparent geometric center of the SNR is not due to high proper motion; evidently the symmetry of the remnant does not indicate its center of expansion. Calvera has a marginally significant proper motion of 69+/-26 mas/yr, corresponding to 86+/-33 km/s for a hypothetical distance of 0.3 kpc. Notably, its vector is away from the Galactic plane, although its high Galactic latitude of b = +37 deg may be more a consequence of its proximity than its velocity. We also provide updated timing solutions for each pulsar. Spannin...

  18. X-1E on Lakebed with Collapsed Nose Gear

    Science.gov (United States)

    1956-01-01

    This photo was taken June 18, 1956 on Rogers Dry Lakebed after Flight 7 of the Bell Aircraft Corporation X-1E with NACA High-Speed Flight Station test pilot Joseph `Joe' Walker at the controls. The first generation X-1s were well known for nose gear failures and the X-1E was no exception. The hard pitch down on landing usually resulted in a collapsed nose gear. The damage rarely was serious but required several days of down-time for repair. The X-1E was the only one to have a true tail skid to protect the empennage from over-rotation during landing. There were four versions of the Bell X-1 rocket-powered research aircraft that flew at the NACA High-Speed Flight Research Station, Edwards, California. The bullet-shaped X-1 aircraft were built by Bell Aircraft Corporation, Buffalo, N.Y. for the U.S. Army Air Forces (after 1947, U.S. Air Force) and the National Advisory Committee for Aeronautics (NACA). The X-1 Program was originally designated the XS-1 for EXperimental Supersonic. The X-1's mission was to investigate the transonic speed range (speeds from just below to just above the speed of sound) and, if possible, to break the 'sound barrier.' Three different X-1s were built and designated: X-1-1, X-1-2 (later modified to become the X-1E), and X-1-3. The basic X-1 aircraft were flown by a large number of different pilots from 1946 to 1951. The X-1 Program not only proved that humans could go beyond the speed of sound, it reinforced the understanding that technological barriers could be overcome. The X-1s pioneered many structural and aerodynamic advances including extremely thin, yet extremely strong wing sections; supersonic fuselage configurations; control system requirements; powerplant compatibility; and cockpit environments. The X-1 aircraft were the first transonic-capable aircraft to use an all-moving stabilizer. The flights of the X-1s opened up a new era in aviation. The first X-1 was air-launched unpowered from a Boeing B-29 Superfortress on January 25

  19. Aging evaluation of class 1E batteries: Seismic testing

    Energy Technology Data Exchange (ETDEWEB)

    Edson, J.L. (EG and G Idaho, Inc., Idaho Falls, ID (USA))

    1990-08-01

    This report presents the results of a seismic testing program on naturally aged class 1E batteries obtained from a nuclear plant. The testing program is a Phase 2 activity resulting from a Phase 1 aging evaluation of class 1E batteries in safety systems of nuclear power plants, performed previously as a part of the US Nuclear Regulatory Commission's Nuclear Plant Aging Research Program and reported in NUREG/CR-4457. The primary purpose of the program was to evaluate the seismic ruggedness of naturally aged batteries to determine if aged batteries could have adequate electrical capacity, as determined by tests recommended by IEEE Standards, and yet have inadequate seismic ruggedness to provide needed electrical power during and after a safe shutdown earthquake (SSE) event. A secondary purpose of the program was to evaluate selected advanced surveillance methods to determine if they were likely to be more sensitive to the aging degradation that reduces seismic ruggedness. The program used twelve batteries naturally aged to about 14 years of age in a nuclear facility and tested them at four different seismic levels representative of the levels of possible earthquakes specified for nuclear plants in the United States. Seismic testing of the batteries did not cause any loss of electrical capacity. 19 refs., 29 figs., 7 tabs.

  20. An aging assessment of transformers in 1E power systems

    International Nuclear Information System (INIS)

    This paper presents the findings of the Idaho National Engineering Laboratory (INEL) Phase 1 study of the effects of age on nuclear power plant Class 1E power transformers, the significance of transformer aging on plant safety, and the capabilities to mitigate the effects of transformer aging to prevent risk significant failures. The following areas were included in the INEL study: The characteristics of Class 1E power transformers used in nuclear power plants were determined. All known transformer stressors were identified, their effect on transformer materials determined, and the effects of these stressors with time assessed. On- and off-line techniques to detect the degradation of all types of transformers were identified and their effectiveness examined. The information provided in reactor operation data bases was evaluated. The capability of various recommendations to mitigate the effects of transformer aging and prevent unexpected transformer failures was evaluated. The risk significance of transformer aging was determined. Conclusions have been made on the effects of aging on transformer performance, the capability to prevent/detect/mitigate aging effects prior to transformer failure, and the effectiveness of current maintenance and monitoring methods

  1. Aging evaluation of class 1E batteries: Seismic testing

    International Nuclear Information System (INIS)

    This report presents the results of a seismic testing program on naturally aged class 1E batteries obtained from a nuclear plant. The testing program is a Phase 2 activity resulting from a Phase 1 aging evaluation of class 1E batteries in safety systems of nuclear power plants, performed previously as a part of the US Nuclear Regulatory Commission's Nuclear Plant Aging Research Program and reported in NUREG/CR-4457. The primary purpose of the program was to evaluate the seismic ruggedness of naturally aged batteries to determine if aged batteries could have adequate electrical capacity, as determined by tests recommended by IEEE Standards, and yet have inadequate seismic ruggedness to provide needed electrical power during and after a safe shutdown earthquake (SSE) event. A secondary purpose of the program was to evaluate selected advanced surveillance methods to determine if they were likely to be more sensitive to the aging degradation that reduces seismic ruggedness. The program used twelve batteries naturally aged to about 14 years of age in a nuclear facility and tested them at four different seismic levels representative of the levels of possible earthquakes specified for nuclear plants in the United States. Seismic testing of the batteries did not cause any loss of electrical capacity. 19 refs., 29 figs., 7 tabs

  2. BEST sensitivity to O(1) eV sterile neutrino

    CERN Document Server

    Barinov, Vladislav; Gorbunov, Dmitry; Ibragimova, Tatiana

    2016-01-01

    Numerous anomalous results in neutrino oscillation experiments can be attributed to interference of ~1 eV sterile neutrino. The specially designed to fully explore the Gallium anomaly Baksan Experiment on Sterile Transitions (BEST) starts next year. We investigate the sensitivity of BEST in searches for sterile neutrino mixed with electron neutrino. Then, performing the combined analysis of all the Gallium experiments (SAGE, GALLEX, BEST) we find the regions in model parameter space (sterile neutrino mass and mixing angle), which will be excluded if BEST agrees with no sterile neutrino hypothesis. For the opposite case, if BEST observes the signal as it follows from the sterile neutrino explanation of the Gallium (SAGE and GALLEX) anomaly, we show how BEST will improve upon the present estimates of the model parameters.

  3. Research of quality control during development of NPP DCS 1E classified software

    International Nuclear Information System (INIS)

    The Nuclear safety depends on right behavior of 1E software, which is a important part of 1E DCS system. Nowadays, user focus on good function of 1E system, but pay little attention to quality control of 1E software. In fact, it's declared in IEC61513 and IEC60880 that 1E software should under strict quality control during all stages of development. This article is related to the practice of 1E DCS system quality control and explores the QC surveillance for 1E software from the user's point of view. (authors)

  4. Podocyte-specific knockout of myosin 1e disrupts glomerular filtration.

    Science.gov (United States)

    Chase, Sharon E; Encina, Christina V; Stolzenburg, Lindsay R; Tatum, Arthur H; Holzman, Lawrence B; Krendel, Mira

    2012-10-01

    Myosin 1e (myo1e) is an actin-dependent molecular motor that plays an important role in kidney functions. Complete knockout of myo1e in mice and Myo1E mutations in humans are associated with nephrotic syndrome and focal segmental glomerulosclerosis. In this paper, we tested the hypothesis that myo1e is necessary for normal functions of glomerular visceral epithelial cells (podocytes) using podocyte-targeted knockout of myo1e. Myo1e was selectively knocked out in podocytes using Cre-mediated recombination controlled by the podocin promoter. Myo1e loss from podocytes resulted in proteinuria, podocyte foot process effacement, and glomerular basement membrane disorganization. Our findings indicate that myo1e expression in podocytes is necessary for normal glomerular filtration and that podocyte defects are likely to represent the primary pathway leading to glomerular disease associated with Myo1E mutations. PMID:22811491

  5. X-1E launch from B-50 mothership

    Science.gov (United States)

    1950-01-01

    it was to be launched on its second flight. It had to be jettisoned to the Muroc desert. Shop experiments soon determined that the deadly explosive culprit for the X-1D, the X-1 #3, and the X-1A was the ulmer leather gasket material used in contact with the liquid oxygen. The loss of the X-1 #3 and the X-1D led the NACA to rebuild the X-1 #2 into a new aircraft. By December 1955, the redesignated X-1E was ready. It featured a new, very thin 4-percent wing along with the existing 8-percent tail, with an efficient low-pressure turbo-pump for the engine. It also contained an ejection seat for the pilot, unlike the original X-1. On October 8, 1957, the aircraft with NACA pilot Joseph A. Walker achieved a speed of Mach 2.24 (1,478 mph). During its second flight career, the new X-1E allowed NACA to gather significant data on high Mach flight and stability questions and to demonstrate improved engine and production technology for incorporation into new USAF aircraft. The X-1E was also used to obtain in-flight data on the improvements achieved with the high-speed wing. These wings, made by Stanley Aircraft, wereonly 3 - 3/8-in. thick at the thickest point and had 343 gauges installed in them for measurement of structural loads and aerodynamic heating. Like the original X-1 it was air launched. This movie clip running about 10 seconds shows a drop from the B-50 mothership, accelerating away under rocket power and at speed making a high altitude contrail.

  6. Senior Centers

    Medline Plus

    Full Text Available ... to do as long as they can. Senior centers, adult day care, transportation, and meals programs are ... older adults to remain in their homes. Senior centers are places where older adults who live independently ...

  7. Excel Center

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Citigroup,one of the World top 500 companies,has now settled in Excel Center,Financial Street. The opening ceremony of Excel Center and the entry ceremony of Citigroup in the center were held on March 31.Government leaders of Xicheng District,the Excel CEO and the heads of Asia-Pacific Region leaders of Citibank all participated in the ceremony.

  8. Job center

    Science.gov (United States)

    To better meet the needs of AGU members, a program has been started to increase the effectiveness of the Job Center activity at the Spring and Fall Meetings. As a result, participation in the Job Center at the 1988 AGU Spring Meeting in Baltimore increased substantially compared to previous Spring Meetings. The number of employers, applicants, and interviews scheduled more than doubled compared to the 1987 Spring Job Center.In order to make the meeting Job Centers even better, a survey is being conducted of employers and applicants who participated in the 1988 Spring Job Center. Evaluation of this survey will be useful in continuing increased participation in and the effectiveness of the Job Center at the 1988 Fall Meeting. Past participants and those interested in the future of the Job Center are encouraged to forward comments and suggestions to AGU, Member Programs Division, 2000 Florida Ave., N.W., Washington, DC 20009.

  9. NuSTAR and INTEGRAL observations of a low/hard state of 1E1740.7-2942

    DEFF Research Database (Denmark)

    Natalucci, Lorenzo; Tomsick, John A.; Bazzano, Angela;

    2014-01-01

    declined significantly. Nearly simultaneous coverage by INTEGRAL is available from its Galactic Center monitoring campaign lasting ~2.5 months. These data probe the hard state spectrum from 1E1740.7-2942 before the flux decline. We find good agreement between the spectra taken with IBIS/ISGRI and Nu......STAR, with the measurements being compatible with a change in flux with no spectral variability. We present a detailed analysis of the NuSTAR spectral and timing data and upper limits for reflection of the high energy emission. We show that the high energy spectrum of this X-ray binary is well described by...

  10. Functional Centering

    CERN Document Server

    Hahn, M

    1996-01-01

    Based on empirical evidence from a free word order language (German) we propose a fundamental revision of the principles guiding the ordering of discourse entities in the forward-looking centers within the centering model. We claim that grammatical role criteria should be replaced by indicators of the functional information structure of the utterances, i.e., the distinction between context-bound and unbound discourse elements. This claim is backed up by an empirical evaluation of functional centering.

  11. Distribution center

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Distribution center is a logistics link fulfill physical distribution as its main functionGenerally speaking, it's a large and hiahly automated center destined to receive goods from various plants and suppliers,take orders,fill them efficiently,and deliver goods to customers as quickly as possible.

  12. The Mysterious Galactic Center Radio Source N3

    Science.gov (United States)

    Ludovici, Dominic; Lang, Cornelia C.; Morris, Mark; Lucien Mutel, Robert; Mills, Elisabeth A. C.; Toomey, James E.; Ott, Juergen

    2016-06-01

    Here we report on new, multi-wavelength radio observations of the mysterious point source "N3" that appears to be located in the vicinity of the Galactic Center. VLA observations between 2 and 50 GHz reveal that N3 is a compact and bright non-thermal source (56 mJy at 10 GHz) which is superimposed upon the non-thermal radio filaments (NTFs) of the Radio Arc. Our highest frequency observations place a strict upper limit of 65x28 milli-arcseconds on the size of this source. We compare our observations to those of Yusef-Zadeh (1987) and Lang (1997) and conclude that N3 is variable over long time scales. Additionally, we present the detection of a compact molecular cloud located adjacent to N3 in projection. CH3CN, CH3OH, CS, HC3N, HNCO, SiO, SO, and NH3 are detected in the cloud and most transitions have FWHM line widths of ~20 km s-1. The rotational temperature determined from the metastable NH3 transitions ranges from 79 K to 183 K depending on the transitions used and the location in the cloud. We present evidence that this molecular cloud is interacting with N3. After exploring the relationship between the NTFs, molecular cloud, and N3, we conclude that N3 likely lies within the Galactic Center. While we are able to rule out many possible physical counterparts, including an active star, HII region, young supernova, AGN, and microquasar, further observations will be required to determine the true nature of this mysterious source.

  13. Lysosomal-associated transmembrane protein 5 (LAPTM5 is a molecular partner of CD1e.

    Directory of Open Access Journals (Sweden)

    Catherine Angénieux

    Full Text Available The CD1e protein participates in the presentation of lipid antigens in dendritic cells. Its transmembrane precursor is transported to lysosomes where it is cleaved into an active soluble form. In the presence of bafilomycin, which inhibits vacuolar ATPase and consequently the acidification of endosomal compartments, CD1e associates with a 27 kD protein. In this work, we identified this molecular partner as LAPTM5. The latter protein and CD1e colocalize in trans-Golgi and late endosomal compartments. The quantity of LAPTM5/CD1e complexes increases when the cells are treated with bafilomycin, probably due to the protection of LAPTM5 from lysosomal proteases. Moreover, we could demonstrate that LAPTM5/CD1e association occurs under physiological conditions. Although LAPTM5 was previously shown to act as a platform recruiting ubiquitin ligases and facilitating the transport of receptors to lysosomes, we found no evidence that LATPM5 controls either CD1e ubiquitination or the generation of soluble lysosomal CD1e proteins. Notwithstanding these last observations, the interaction of LAPTM5 with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 might influence the role of CD1e in the presentation of lipid antigens.

  14. Senior Centers

    Medline Plus

    Full Text Available ... variety of social and recreational activities. [Karen Albers] We provide a wide variety of activities -- physical, health, ... senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, tap dancing, ballroom dancing, ...

  15. Senior Centers

    Medline Plus

    Full Text Available ... transportation, and meals programs are long-term care services available in the community which make it easier ... about senior centers and other long-term care services available in your community, contact the Eldercare Locator ...

  16. Senior Centers

    Medline Plus

    Full Text Available ... Karen Albers] We provide a wide variety of activities -- physical, health, mental health programs with Senior Plus, cognitive ... of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ...

  17. Senior Centers

    Medline Plus

    Full Text Available [Narrator] Living independently at home is something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, and meals programs are ...

  18. Senior Centers

    Medline Plus

    Full Text Available ... Living independently at home is something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, and meals programs are long- ...

  19. Senior Centers

    Medline Plus

    Full Text Available ... of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ... chi, tap dancing, ballroom dancing, square dancing, chair exercise, arthritis classes, yoga, and lots of dancing. [Narrator] ...

  20. Senior Centers

    Medline Plus

    Full Text Available ... something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, ... adults who live independently can go to find a variety of social and recreational activities. [Karen Albers] ...

  1. Complete Genome Sequence of a Bovine Viral Diarrhea Virus Subgenotype 1e Strain Isolated in Switzerland

    OpenAIRE

    Stalder, Hanspeter; Schweizer, Matthias; Bachofen, Claudia

    2015-01-01

    We sequenced the complete genome of the bovine viral diarrhea virus (BVDV) strain Carlito. It belongs to the subgenotype 1e that is described in Europe only and represents the second most prevalent subgenotype in Switzerland. This is the first report of a full-length sequence of BVDV-1e.

  2. Physicochemical and biological characterization of 1E10 Anti-Idiotype vaccine

    Directory of Open Access Journals (Sweden)

    Machado Yoan J

    2011-11-01

    Full Text Available Abstract Background 1E10 monoclonal antibody is a murine anti-idiotypic antibody that mimics N-glycolyl-GM3 gangliosides. This antibody has been tested as an anti-idiotypic cancer vaccine, adjuvated in Al(OH3, in several clinical trials for melanoma, breast, and lung cancer. During early clinical development this mAb was obtained in vivo from mice ascites fluid. Currently, the production process of 1E10 is being transferred from the in vivo to a bioreactor-based method. Results Here, we present a comprehensive molecular and immunological characterization of 1E10 produced by the two different production processes in order to determine the impact of the manufacturing process in vaccine performance. We observed differences in glycosylation pattern, charge heterogeneity and structural stability between in vivo-produced 1E10 and bioreactor-obtained 1E10. Interestingly, these modifications had no significant impact on the immune responses elicited in two different animal models. Conclusions Changes in 1E10 primary structure like glycosylation; asparagine deamidation and oxidation affected 1E10 structural stability but did not affect the immune response elicited in mice and chickens when compared to 1E10 produced in mice.

  3. Broadband X-ray Spectral Investigations of Magnetars, 4U 0142+61, 1E 1841-045, 1E 2259+586, and 1E 1048.1-5937

    CERN Document Server

    Weng, Shan-Shan

    2015-01-01

    We have generated an extended version of rather simplified but physically oriented three-dimensional magnetar emission model, STEMS3D, to allow spectral investigations up to 100 keV. We have then applied it to the broadband spectral spectra of four magnetars: 4U 0142+61, 1E 1841-045, 1E 2259+586 and 1E 1048.1-5937, using data collected with Swift/XRT or XMM-Newton in soft X-rays, and Nuclear Spectroscopic Telescope Array in the hard X-ray band. We found that the hard X-ray emission of 4U 0142+61 was spectrally hard compared to the earlier detections, indicating that the source was likely in a transition to or from a harder state. We find that the surface properties of the four magnetars are consistent with what we have obtained using only the soft X-ray data with STEMS3D, implying that our physically motivated magnetar emission model is a robust tool. Based on our broadband spectral investigations, we conclude that resonant scattering of the surface photons in the magnetosphere alone cannot account for the ha...

  4. Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1

    Directory of Open Access Journals (Sweden)

    Edavana VK

    2011-11-01

    Full Text Available Vineetha Koroth Edavana1, Xinfeng Yu1, Ishwori B Dhakal1, Suzanne Williams1, Baitang Ning2, Ian T Cook3, David Caldwell1, Charles N Falany3, Susan Kadlubar11Division of Medical Genetics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; 3Department of Pharmacology, University of Alabama, Birmingham, AL, USAAbstract: Fulvestrant (Faslodex™ is a pure antiestrogen that is approved to treat hormone receptor-positive metastatic breast cancer in postmenopausal women. Previous studies have demonstrated that fulvestrant metabolism in humans involves cytochromes P450 and UDP-glucuronosyltransferases (UGTs. To date, fulvestrant sulfation has not been characterized. This study examined fulvestrant sulfation with nine recombinant sulfotransferases and found that only SULT1A1 and SULT1E1 displayed catalytic activity toward this substrate, with Km of 4.2 ± 0.99 and 0.2 ± 0.16 µM, respectively. In vitro assays of 104 human liver cytosols revealed marked individual variability that was highly correlated with β-naphthol sulfation (SULT1A1 diagnostic substrate; r = 0.98, P < 0.0001, but not with 17ß-estradiol sulfation (SULT1E1 diagnostic substrate; r = 0.16, P = 0.10. Fulvestrant sulfation was correlated with both SULT1A1*1/2 genotype (P value = 0.023 and copy number (P < 0.0001. These studies suggest that factors influencing SULT1A1/1E1 tissue expression and/or enzymatic activity could influence the efficacy of fulvestrant therapy.Keywords: fulvestrant, sulfotransferase, genotype, copy number

  5. Senior Centers

    Medline Plus

    Full Text Available ... provide a wide variety of activities -- physical, health, mental health programs with Senior Plus, cognitive programs, a wide variety of general activities, billiards, Bingo, lots of games. [Narrator] Many senior centers also offer exercise programs. [Karen Albers] We offer aerobics, tai chi, ...

  6. Hastings Center

    Science.gov (United States)

    ... BLOG We have long had the ability, we humans, to work outside the bounds of evolution. Dairy cattle, maize, and all sorts of dog ... intervention. However, in the past, the scope of human intervention was rather… Read more Share: ... Evolution? Read more HASTINGS NEWS Hastings Center research scholar ...

  7. Senior Centers

    Medline Plus

    Full Text Available ... dancing. [Narrator] These centers can provide entree to new activities and expand a person’s social contacts. [Karen ... meeting all their interests and introducing them to new things; whether it’s an arts and crafts project, ...

  8. Senior Centers

    Medline Plus

    Full Text Available ... transportation, and meals programs are long-term care services available in the community which make it easier for older adults to ... about senior centers and other long-term care services available in your community, contact the Eldercare Locator at 1-800-677- ...

  9. The Unusual Galactic Center Radio Source N3

    Science.gov (United States)

    Ludovici, D. A.; Lang, C. C.; Morris, M. R.; Mutel, R.; Mills, E. A. C.; Toomey, J. E., IV; Ott, J.

    2016-08-01

    Here, we report on new multi-wavelength radio observations of the unusual point source “N3” that appears to be located in the vicinity of the Galactic Center (GC). VLA observations between 2 and 50 GHz reveal that N3 is a compact and bright source (56 mJy at 10 GHz) with a non-thermal spectrum superimposed upon the non-thermal radio filaments (NTFs) of the Radio Arc. Our highest frequency observations place a strict upper limit of 65 × 28 mas on the size of N3. We compare our observations to those of Yusef-Zadeh & Morris and Lang et al., and conclude that N3 is variable over long timescales. Additionally, we present the detection of a compact molecular cloud located adjacent to N3 in projection. CH3CN, CH3OH, CS, HC3N, HNCO, SiO, SO, and NH3 are detected in the cloud, and most transitions have FWHM line widths of ˜20 km s‑1. The rotational temperature determined from the metastable NH3 transitions ranges from 79 to 183 k depending on the transitions used. We present evidence that this molecular cloud is interacting with N3. After exploring the relationship between the NTFs, molecular cloud, and N3, we conclude that N3 likely lies within the GC. We are able to rule out the H ii region, young supernova, active star, AGN, and micro-quasar hypotheses for N3. While a micro-blazar may provide a viable explanation for N3, additional observations are needed to determine the physical counterpart of this mysterious source.

  10. Lysosomal-Associated Transmembrane Protein 5 (LAPTM5) Is a Molecular Partner of CD1e

    OpenAIRE

    Angénieux, Catherine; Waharte, François; Gidon, Alexandre; Signorino-Gelo, François; Wurtz, Virginie; Hojeij, Rim; Proamer, Fabienne; Gachet, Christian; Van Dorsselaer, Alain; Hanau, Daniel; Salamero, Jean; de la Salle, Henri

    2012-01-01

    The CD1e protein participates in the presentation of lipid antigens in dendritic cells. Its transmembrane precursor is transported to lysosomes where it is cleaved into an active soluble form. In the presence of bafilomycin, which inhibits vacuolar ATPase and consequently the acidification of endosomal compartments, CD1e associates with a 27 kD protein. In this work, we identified this molecular partner as LAPTM5. The latter protein and CD1e colocalize in trans-Golgi and late endosomal compar...

  11. Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes

    OpenAIRE

    Garcia-Alles, Luis F.; Giacometti, Gaelle; Versluis, Cees; Maveyraud, Laurent; de Paepe, Diane; Guiard, Julie; Tranier, Samuel; Gilleron, Martine; Prandi, Jacques; Hanau, Daniel; Heck, Albert J.R.; Mori, Lucia; De Libero, Gennaro; Puzo, Germain; Mourey, Lionel

    2011-01-01

    CD1e is the only human CD1 protein existing in soluble form in the late endosomes of dendritic cells, where it facilitates the processing of glycolipid antigens that are ultimately recognized by CD1b-restricted T cells. The precise function of CD1e remains undefined, thus impeding efforts to predict the participation of this protein in the presentation of other antigens. To gain insight into its function, we determined the crystal structure of recombinant CD1e expressed in human cells at 2.90...

  12. Construction of a recombinant adenovirus Vector of human papillomavirus type 16 L1_E7c

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Human papillomaviruses are closely associated with human cervical cancer, especially HPV types 16 and 18. At present, HPV can not be produced in large quantity; it also has tumorgenicity and these properties of HPV have seriously hampered the development of HPV vaccine. HPV type 16 L1 proteins can assembled into virus-like particles (VLP), which are morphologically identical to the nature virion. In order to develop the recombinant adenovirus vectors of HPV, we constructed a recombinant adenovirus shuttle plasmid pCA14 L1-E7c. Methods: Human papillomavirus type 16 L1 open reading frame without terminator codon (TAA) (5559- 7152) and E7c (682- 855) were amplified using PCR. The L1 and E7c fragments were inserted into pGEM-T easy vectors by T- A strategy, named pTAL1 and pTAE7c. pTAL1 was cut with Hind III and BglII, the pTAE7c with BamHI and ClaI. The L1 DNA fragment, E7c and pBluesscript SK were ligated together using T4 DNA ligase. pBSL1-E7c and pBSL1-E7c was digested with Hind III and Xhol. The L1-E7c fragment was inserted into adenovirus shuttle plasmids pCAl4, named pCAl4L1-E7c. DNA sequence results indicated that The L1-E7c DNA fragment can encode the HPV16L1-E7 fusion protein correctly. Results: The L1 and E7c DNA fragments were amplified by PCR and recombinant plasmid pTAL1, pTAE7c, pBSL1-E7c and pCA14L1-E7c were constructed correctly. The pCAl4L1-E7c can be used in the further research work, cotransfected the 293 cell with the parent adenovirus pBHG10. Conclusion: Our results indicated that we have constructed a HPV16L1-E7 fusion DNA fragments and the adenovirus shuttle plasmids pCALl-E7c for the further research.

  13. Centered Pyramids

    OpenAIRE

    Brigger, P.; F. Müller; Illgner, K.; Unser, M.

    1999-01-01

    Quadtree-like pyramids have the advantage of resulting in a multiresolution representation where each pyramid node has four unambiguous parents. Such a centered topology guarantees a clearly defined up-projection of labels. This concept has been successfully and extensively used in applications of contour detection, object recognition and segmentation. Unfortunately, the quadtree-like type of pyramid has poor approximation powers because of the employed piecewise-constant image model. This pa...

  14. IRASM Center

    International Nuclear Information System (INIS)

    IRASM is a national center for radiation processing developed around an industrial Co60 gamma irradiator. Being a department in an R and D national institute, IRASM Center is dealing with radiation treatment, pre/post microbiological control, validation of irradiation sterilization, detection of irradiated foodstuffs. Training is available for operators of new irradiation facilities focused on radiation technologies, dosimetry, sterilization, food treatment, conservation by irradiation of cultural heritage, quality assurance. Expertise on proper choosing the plastics for packaging versus dose is offered to the potential clients. IRASM Center is also involved in interdisciplinary applied research like chitosan treatment, sterile male technique or implementation of irradiation step in production of pharmaceuticals. All important activities: irradiation treatment, dosimetry, microbiology, detection of irradiated food, radioprotection, nuclear safety, physical protection. are performed in accordance with the proper standards in the frame of a certified quality management system. In this way Co60 industrial sources, a byproduct of certain nuclear power plants like Candu type, appear to be the key of a large technical and R and D domain. (authors)

  15. National Health Information Center

    Science.gov (United States)

    ... ODPHP National Health Information Center National Health Information Center The National Health Information Center (NHIC) is sponsored ... interest View the NHO calendar . Federal Health Information Centers and Clearinghouses Federal Health Information Centers and Clearinghouses ...

  16. Epitope-mapped monoclonal antibodies against the HPV16E1--E4 protein.

    Science.gov (United States)

    Doorbar, J; Ely, S; Coleman, N; Hibma, M; Davies, D H; Crawford, L

    1992-03-01

    The human papillomavirus (HPV) E1--E4 protein is the only nonstructural late protein encoded by the virus. We have isolated three hybridomas producing monoclonal antibodies to the E1--E4 protein of HPV16, which is the HPV type most frequently associated with cervical cancer. The three antibodies (TVG 401, 402, and 403) detect adjacent epitopes within the major seroreactive region of the molecule and show no reactivity against the E4 proteins of HPV1, HPV2, HPV4, or HPV6. The E1--E4 protein migrates as a 10K species on SDS-gel electrophoresis and forms cytoplasmic inclusion granules in infected cells in vitro similar in appearance to those produced by HPV1 in benign warts. In naturally occurring HPV16-induced tumors the E1--E4 protein was detected in the cytoplasm of cells in the upper layers of the lesion in areas in which HPV16 DNA replication was occurring, as determined by in situ hybridization. Although the epitopes recognized by these monoclonal antibodies survive brief fixation in 5% formaldehyde, reactivity was destroyed by prolonged fixation. These monoclonal antibodies represent the first against HPV16 E1--E4 and should complement those already available to E7 and L1 for the screening of frozen sections of clinical biopsies and will be of value in monitoring the progression of HPV infection from benign lesions to invasive cancer. PMID:1371027

  17. Centering research

    DEFF Research Database (Denmark)

    Katan, Lina Hauge; Baarts, Charlotte

    share as the common aim of both research and education. Despite some similarities, we find that how the two groups engage in and benefit from reading and writing diverges significantly. Thus we have even more reason to believe that centering practice-based teaching on these aspects of research is a good......’ exercises tend to dominate the common understandings of research-based learning. Here we address a specific area of inquiry overlooked by previous studies: whether and how reading, thinking and writing indeed share the same learning potentials as the practical foundation for research-based teaching....... In the humanities and social sciences, integrated acts of reading, writing and thinking account for an obvious and substantial overlap in student and researcher practices, creating a clear opportunity for research-based teaching. Moreover, our empirical data point to reading, thinking and writing as quintessential...

  18. Dedication for Safety-Related Fuses used in Class-1E Power System

    International Nuclear Information System (INIS)

    The safety-related fuses used in class-1E power system provide overcurrent protection for electrical system and isolate the class 1E circuit from a fault or overload condition. These days, the number of nuclear grade suppliers has been reduced. Accordingly, commercial grade, instead of safety-related, fuses are procured and used in the utilities through the dedication process. Therefore, this paper introduces the commercial grade fuse dedication process/engineering and how to assure the quality requirements with this process and engineering. The fuses used in class-1E power system are to protect overcurrent and to isolate fault. Therefore the fuse for acceptance in order to improve the quality and reliability for commercial grade fuses shall be dedicated. The fuse resistance value may be useful as an indicator of acceptance. The current carrying capacity test can change the fuse performance properties. Therefore these critical characteristics are needed for additional review and analysis with fuse manufactures

  19. Aging studies of 1E power and reactor protection systems, and transformers

    International Nuclear Information System (INIS)

    Previous 1E power and reactor protection system Phase 1 aging studies have shown that a significant percentage of failures are not being detected by planned inspection, surveillance and monitoring methods (IS and MM). This paper presents a Phase 2 study that was performed to determine the effectiveness of current IS and MM, identify the risk significant 1E power system components, and identify additional IS and MM that may effectively supplement current practices. In addition, a Phase 1 aging study of 1E power system transformers was performed to identify stressors and failure mechanisms, investigate whether transformers are showing signs of increased failure rates as they grow older, and to determine if current surveillance methods are effective in mitigating aging effects

  20. X-ray spectral states of microquasars

    CERN Document Server

    Malzac, Julien

    2008-01-01

    We discuss the origin of the dramatically different X-ray spectral shapes observed in the Low Hard State (LHS: dominated by thermal comptonisation) and the High Soft State (HSS: dominated by the accretion disc thermal emission and non-thermal comptonisation in the corona). We present numerical simulations using a new code accounting for the so-called synchrotron boiler effect. These numerical simulations when compared to the data allow us to constrain the magnetic field and temperature of the hot protons in the corona. For the hard state of Cygnus X-1 we find a magnetic field below equipartition with radiation, suggesting that the corona is not powered through magnetic field dissipation (as assumed in most accretion disc corona models). On the other hand, our results also point toward proton temperatures that are substantially lower than typical temperatures of the ADAF models. Finally, we show that in both spectral states Comptonising plasma could be powered essentially through power-law acceleration of non-...

  1. Microquasars and ulxs: fossils of grb sources

    Directory of Open Access Journals (Sweden)

    I. F. Mirabel

    2004-01-01

    Full Text Available Las fuentes de destellos gamma de larga duraci on probablemente resultan del colapso de estrellas masivas en sistemas binarios. Despu es del colapso de la estrella primaria el sistema binario puede permanecer ligado gravitacionalmente dejando como remanente un microcu asar o una fuente Ultraluminosa en rayos X (ULX. En este contexto, los microcu asares y las ULXs son f osiles de las fuentes de destellos gamma y contienen claves sobre la f sica y astrof sica de las fuentes de destellos gamma progenitoras. Aqu muestro que la identi caci on del lugar de nacimiento de los microcu asares acota las propiedades de las estrellas progenitoras de objetos compactos, y que la velocidad con que es disparado el microcu asar puede ser usada para acotar la energ a de la explosi on de las estrellas masivas que son progenitoras de estrellas de neutrones y agujeros negros. Las observaciones muestran que los sistemas binarios con estrellas de neutrones LS 5039, LSI +61 303 y el agujero negro de baja masa en GRO J1655-40 se formaron en explosiones energ eticas, mientras que los agujeros negros de masas mayores (M 10 M en Cygnus X-1 y GRS 1915+105 se formaron por colapso directo en oscuridad completa o en supernovas de baja luminosidad. La asociaci on con c umulos de estrellas masivas de las estrellas de neutrones en LSI +61 303 y de los magnetares SGR 1806-20 and SGR 1900+14, sugiere que estrellas muy masivas (M 50 M pueden bajo ciertas circunstancias, terminar como estrellas de neutrones y no como agujeros negros. Lss fuentes de destellos gamma de larga duraci on contienen los mismos ingredientes b asicos que los microcu asares y las ULXs, objetos compactos con discos de acreci on y chorros relativistas en sistemas binarios, y las analogias fenomenol ogicas encontradas entre los microcu asares y N ucleos Activos de Galaxias podr an ser extendidas a las fuentes de destellos gamma.

  2. SS433: The microquasar link with ulxs?

    Directory of Open Access Journals (Sweden)

    P. A. Charles

    2004-01-01

    Full Text Available SS433 es el microcuasar prototipo de la Galaxia y posiblemente incluso an alogo a las fuentes ULX si se tiene en cuenta la energ a cin etica de los \\jets". Sin embargo y a pesar de 20 a~nos de estudio, nuestras restricciones sobre la naturaleza del sistema binario son extremadamente grandes debido a la di cultad de localizar rasgos espectrales capaces de revelar la naturaleza y el movimiento del donador de la masa. Los espectros azules de alta resoluci on recientemente obtenidos cuando el disco (en precesi on se encuentra de per l, sugieren que la binaria se halla cerca de la fase de envolvente com un, lo cual hace extremadamente dif cil obtener las restricciones cin eticas. Sin embargo, encontramos evidencia de un donador masivo como era de esperar para la muy alta tasa de transferencia de masa inferida y comparamos las propiedades de SS433 con las de Cyg X3.

  3. Exceptional flaring activity of the anomalous X-ray pulsar 1E 1547.0-5408

    CERN Document Server

    Savchenko, V; Beckmann, V; Produit, N; Walter, R

    2009-01-01

    (Abridged) We studied an exceptional period of activity of the anomalous X-ray pulsar 1E 1547.0-5408 in January 2009, during which about 200 bursts were detected by INTEGRAL. The major activity episode happened when the source was outside the field of view of all the INTEGRAL instruments. But we were still able to study the properties of 84 bursts detected simultaneously by the anti-coincidence shield of the spectrometer SPI and by the detector of the imager ISGRI. We find that the luminosity of the 22 January 2009 bursts of 1E 1547.0-5408 was > 1e42 erg/s. This luminosity is comparable to that of the bursts of soft gamma repeaters (SGR) and is at least two orders of magnitude larger than the luminosity of the previously reported bursts from AXPs. Similarly to the SGR bursts, the brightest bursts of 1E 1547.0-5408 consist of a short spike of ~100 ms duration with a hard spectrum, followed by a softer extended tail of 1-10 s duration, which occasionally exhibits pulsations with the source spin period of ~2 s. ...

  4. An application study for the class 1E digital control and monitoring system

    International Nuclear Information System (INIS)

    This paper presents an application study for the Class 1E digital control and monitoring system to the next Japanese plants, especially about MMIS. The system architecture of hardware and software is also introduced, which will explain the strategic plan for the necessary software verification and validation according to the latest requirement from Japanese regulatory guide. (author)

  5. Suzaku Studies of the Supernova Remnant CTB~109 Hosting the Magnetar 1E~2259+586

    CERN Document Server

    Nakano, Toshio; Hiraga, Junoko S; Uchiyama, Hideki; Kaneda, Hidehiro; Enoto, Teruaki

    2015-01-01

    Ages of the magnetar 1E 2259+586 and the associated supernova remnant CTB~109 were studied. Analyzing the Suzaku data of CTB~109, its age was estimated to be $\\sim$14~kyr, which is much shorter than the measured characteristic age of 1E 2259+586, 230 kyr. This reconfirms the previously reported age discrepancy of this magnetar/remnant association, and suggests that the characteristic ages of magnetars are generally over-estimated as compared to their true ages. This discrepancy is thought to arise because the former are calculated without considering decay of the magnetic fields. This novel view is supported independently by much stronger Galactic-plane concentration of magnetars than other pulsars. The process of magnetic field decay in magnetars is mathematically modeled. It is implied that magnetars are much younger objects than previously considered, and can dominate new-born neutron stars.

  6. Implementation of 1E digital platform common Q in AP1000 DCS

    International Nuclear Information System (INIS)

    As a generation III passive PWR, AP1000 is advanced and economical. This article emphasizes on the hardware and software description of Common Q, which is the 1E digital platform implemented in AP1000 DCS. And also it gives a introduction of implementation of Common Q in Reactor Protection and Safety Monitoring System and Past Accident Monitoring System. This article gives a brief comparison between Common Q and TXS. TXS is the 1E digital platform used in LingAo Phase II Nuclear Power Station and TaiShan Nuclear Power Station, which is generation III Evolutionary Pressurized Water Reactor. The aim of this article is to present both Common Q (used in AP1000) and TXS (used in EPR) to people who are involved in design, complete of system, star-up of Nuclear Power Station DCS. (authors)

  7. An internal mechanism for the anti-glitch observed in AXP 1E 2259+586

    CERN Document Server

    Ranea-Sandoval, Ignacio F

    2015-01-01

    Magnetars are fascinating objects that are thought to be neutron stars powered by their strong internal magnetic fields. Clear evidence of a sudden spin-down was detected in the Anomalous X-ray Pulsar AXP 1E 2259+586, an object cataloged as a magnetar. This event received the name "anti-glitch". In this work we present a simple internal mechanism which could account for the observed sudden spin-down of the star.

  8. VizieR Online Data Catalog: MAGIC map of 1E 2259+586 (Aleksic+, 2013)

    Science.gov (United States)

    Aleksic, J.; Antonelli, L. A.; Antoranz, P.; Asensio, M.; Barres de Almeida, U.; Barrio, J. A.; Becerra Gonzalez, J.; Bednarek, W.; Berger, K.; Bernardini, E.; Biland, A.; Blanch, O.; Bock, R. K.; Boller, A.; Bonnoli, G.; Borla Tridon, D.; Bretz, T.; Carmona, E.; Carosi, A.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Cossio, L.; Covino, S.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Caneva, G.; de Cea Del Pozo, E.; de Lotto, B.; Delgado Mendez, C.; Diago Ortega, A.; Doert, M.; Dominis Prester, D.; Dorner, D.; Doro, M.; Eisenacher, D.; Elsaesser, D.; Ferenc, D.; Fonseca, M. V.; Font, L.; Fruck, C.; Garcia Lopez, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Giavitto, G.; Godinovic, N.; Gonzalez Munoz, A.; Gozzini, S. R.; Hadamek, A.; Hadasch, D.; Hafner, D.; Herrero, A.; Hose, J.; Hrupec, D.; Huber, B.; Jankowski, F.; Jogler, T.; Kadenius, V.; Klepser, S.; Knoetig, M. L.; Krahenbuhl, T.; Krause, J.; Kushida, J.; La Barbera, A.; Lelas, D.; Leonardo, E.; Lewandowska, N.; Lindfors, E.; Lombardi, S.; Lopez, M.; Lopez-Coto, R.; Lopez-Oram as A., Lorenz E., Makariev M., Maneva G., Mankuzhiyil N., Mannheim K., Maraschi L., Marcote B., Mariotti M., Martinez M., Mazin D., Meucci M., Miranda J.M., Mirzoyan R., Moldon J., Moralejo A., Munar-Adrover P., Niedzwiecki A., Nieto D., Nilsson K., Nowak N., Orito R., Paiano S., Palatiello M., Paneque D., Paoletti R., Paredes J.M., Partini S., Persic M., Pilia M., Pochon J., Prada F., Prada Moroni P.G., Prandini E., Puljak I., Reichardt I., Reinthal R., Rhode W., Ribo M., Rico J., Rugamer S., Saito K., Saito T.Y., Salvati M., Satalecka K., Scalzotto V., Scapin V., Schultz C., Saggion A., Schweizer T., Shore S.N., Sillanpaa A., Sitarek J., Snidaric I., Sobczynska D., Spanier F., Spiro S., Stamatescu V., Stamerra A., Steinke B., Storz J., Sun S., Suric T., Takalo L., Takami H., Tavecchio F., Temnikov P., Terzic T., Tescaro D., Teshima M., Tibolla O., Torres D.F., Toyama T., Treves A., Uellenbeck M., Vogler P., Wagner R.M., Weitzel Q., Zabalza V., Zandanel F., Zanin R., Rea N.

    2012-11-01

    We observed the two sources with atmospheric Cherenkov telescopes in the very high energy range (E>100GeV). 4U 0142+61 was observed with the MAGIC I telescope in 2008 for ~25h and 1E 2259+586 was observed with the MAGIC stereoscopic system in 2010 for ~14h. The data were analyzed with the standard MAGIC analysis software. (3 data files).

  9. Overview of newly developed IEEE guide for performing aging assessments of class 1E electrical equipment

    International Nuclear Information System (INIS)

    The IEEE Power Engineering Committee has issued a standard that supplements existing IEEE assessment standards by providing guidance for identifying, evaluating, and mitigating aging degradation effects. The new standard, IEEE Standard 1205-1993, IEEE Guide for Assessing, Monitoring and Mitigating Aging Effects on Class 1E Equipment Used in Nuclear Power Generating Stations, was developed by Working Group 3.4, Aging Assessment Guidelines. This paper presents an overview of IEEE Standard 1205-1993

  10. An approach to maintaining qualification of Class-1E equipment in the mild environment

    International Nuclear Information System (INIS)

    In a paper presented at the February 1983 IEEE Winter Power Conference in New York, the authors presented a method of qualifying Class-1E equipment in the so-called ''mild environment'' (Vol. PAS-102, No. 8) WM017-1. This presentation discusses a method for surveillance and testing that may be used to maintain equipment qualification in the mild environment, which when used in conjunction with the aforementioned paper will provide the total concept

  11. Mitochondrial superoxide generation is diminished during glucose-stimulated insulin secretion in INS-1E cells

    Czech Academy of Sciences Publication Activity Database

    Špaček, Tomáš; Hlavatá, Lydie; Ježek, Petr

    Elsevier. Roč. 1777, Suppl. (2008), S48-S48. ISSN 0005-2728. [European Bioenergetics Conference /15./. 19.07.2008-24.07.2008, Dublin] R&D Projects: GA AV ČR(CZ) IAA500110701; GA MZd NR9183 Institutional research plan: CEZ:AV0Z50110509 Keywords : cpo1 * superoxide * INS-1E cells * glucose-stimulated insulin secretion Subject RIV: ED - Physiology

  12. Superoxide generation is diminished during glucose-stimulated insulin secretion in INS-1E cells

    Czech Academy of Sciences Publication Activity Database

    Ježek, Petr; Hlavatá, Lydie; Špaček, Tomáš

    2008-01-01

    Roč. 275, Suppl.1 (2008), s. 310-310. ISSN 1742-464X. [FEBS Congress /33./ and IUBMB Conference /11./. 28.06.2008-03.07.2008, Athens] R&D Projects: GA MZd(CZ) NR7917; GA AV ČR(CZ) IAA500110701 Institutional research plan: CEZ:AV0Z50110509 Keywords : cpo1 * superoxide production * glucose-stimulated insulin secretion * INS-1E cells Subject RIV: ED - Physiology

  13. Phenotypic diversity of toxigenic Vibrio cholerae O1 E1 Tor strains identified in China

    Institute of Scientific and Technical Information of China (English)

    赵璇

    2014-01-01

    Objective To understand the phenotypic diversity of toxigenic Vibrio cholerae O1 E1 Tor strains isolated from different provinces in China during the last 50 years.Methods Traditional biotyping testings including susceptibility to polymyxin B,sensitivity to groupⅣphage,Voges-Proskauer test and haemolysis of sheep erythrocytes were conducted.Results Data from Biotype-specific phenotype analysis revealed that only 133 isolates carried the typical E1 Tor phenotypes while the other 251

  14. Evidence for the magnetar nature of 1E 161348-5055 in RCW 103

    Science.gov (United States)

    D'Aì, A.; Evans, P. A.; Burrows, D. N.; Kuin, N. P. M.; Kann, D. A.; Campana, S.; Maselli, A.; Romano, P.; Cusumano, G.; La Parola, V.; Barthelmy, S. D.; Beardmore, A. P.; Cenko, S. B.; De Pasquale, M.; Gehrels, N.; Greiner, J.; Kennea, J. A.; Klose, S.; Melandri, A.; Nousek, J. A.; Osborne, J. P.; Palmer, D. M.; Sbarufatti, B.; Schady, P.; Siegel, M. H.; Tagliaferri, G.; Yates, R.; Zane, S.

    2016-08-01

    We report on the detection of a bright, short, structured X-ray burst coming from the supernova remnant RCW 103 on 2016 June 22 caught by the Swift/BAT monitor, and on the follow-up campaign made with Swift/XRT, Swift/UVOT and the optical/NIR GROND detector. The characteristics of this flash, such as duration and spectral shape, are consistent with typical short bursts observed from soft gamma repeaters. The BAT error circle at 68% confidence range encloses the point-like X-ray source at the centre of the nebula, 1E 161348-5055. Its nature has been long debated due to a periodicity of 6.67 hr in X-rays, which could indicate either an extremely slow pulsating neutron star, or the orbital period of a very compact X-ray binary system. We found that 20 minutes before the BAT trigger, the soft X-ray emission of 1E 161348-5055 was a factor of ˜ 100 higher than measured two years earlier, indicating that an outburst had already started. By comparing the spectral and timing characteristics of the source in the two years before the outburst and after the BAT event, we find that, besides a change in luminosity and spectral shape, also the 6.67 hr pulsed profile has significantly changed with a clear phase shift with respect to its low-flux profile. The UV/optical/NIR observations did not reveal any counterpart at the position of 1E 161348-5055. Based on these findings, we associate the BAT burst with 1E 161348-5055, we classify it as a magnetar, and pinpoint the 6.67 hr periodicity as the magnetar spin period.

  15. Neutronic analysis of the 1D and 1E banks reflux detection system

    International Nuclear Information System (INIS)

    Two H Canyon neutron monitoring systems for early detection of postulated abnormal reflux conditions in the Second Uranium Cycle 1E and 1D Mixer-Settle Banks have been designed and built. Monte Carlo neutron transport simulations using the general purpose, general geometry, n-particle MCNP code have been performed to model expected response of the monitoring systems to varying conditions.The confirmatory studies documented herein conclude that the 1E and 1D neutron monitoring systems are able to achieve adequate neutron count rates for various neutron source and detector configurations, thereby eliminating excessive integration count time. Neutron count rate sensitivity studies are also performed. Conversely, the transport studies concluded that the neutron count rates are statistically insensitive to nitric acid content in the aqueous region and to the transition region length. These studies conclude that the 1E and 1D neutron monitoring systems are able to predict the postulated reflux conditions for all examined perturbations in the neutron source and detector configurations. In the cases examined, the relative change in the neutron count rates due to postulated transitions from normal 235U concentration levels to reflux levels remain satisfactory detectable

  16. Neutronic analysis of the 1D and 1E banks reflux detection system

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, A.

    1999-12-21

    Two H Canyon neutron monitoring systems for early detection of postulated abnormal reflux conditions in the Second Uranium Cycle 1E and 1D Mixer-Settle Banks have been designed and built. Monte Carlo neutron transport simulations using the general purpose, general geometry, n-particle MCNP code have been performed to model expected response of the monitoring systems to varying conditions.The confirmatory studies documented herein conclude that the 1E and 1D neutron monitoring systems are able to achieve adequate neutron count rates for various neutron source and detector configurations, thereby eliminating excessive integration count time. Neutron count rate sensitivity studies are also performed. Conversely, the transport studies concluded that the neutron count rates are statistically insensitive to nitric acid content in the aqueous region and to the transition region length. These studies conclude that the 1E and 1D neutron monitoring systems are able to predict the postulated reflux conditions for all examined perturbations in the neutron source and detector configurations. In the cases examined, the relative change in the neutron count rates due to postulated transitions from normal {sup 235}U concentration levels to reflux levels remain satisfactory detectable.

  17. The speed of the `bullet' in the merging galaxy cluster 1E0657-56

    Science.gov (United States)

    Springel, Volker; Farrar, Glennys R.

    2007-09-01

    Deep Chandra exposures of the hot galaxy cluster 1E0657-56 have revealed a highly dynamical state of the system due to an ongoing merger with a massive subcluster. The system is observed shortly after the first core-passage of the infalling subcluster, which moves approximately in the plane of the sky and is preceded by a prominent bow shock with Mach number . The inferred shock velocity of ~4700kms-1 has been commonly interpreted as the velocity of the `bullet' subcluster itself in the rest frame of the parent cluster. This velocity is unexpectedly high in the Lambda cold dark matter (ΛCDM) cosmology, which may require non-trivial modifications in the dark sector such as additional long-range scalar forces if taken at face value. Here we present explicit hydrodynamical toy models of galaxy cluster mergers which very well reproduce the observed dynamical state of 1E0657-56 and the mass models inferred from gravitational lensing observations. However, despite a shock speed of 4500kms-1, the subcluster's mass centroid is moving only with ~2700kms-1 in the rest frame of the parent cluster. The difference arises in part due to a gravitationally induced inflow velocity of the gas ahead of the shock towards the bullet, which amounts to ~1100kms-1 for our assumed 10:1 mass ratio of the merger. A second effect is that the shock front moves faster than the subcluster itself, enlarging the distance between the subcluster and the bow shock with time. We also discuss the expected location of the lensing mass peak relative to the hydrodynamical features of the flow, and show that their spatial separation depends sensitively on the relative concentrations and gas fractions of the merging clusters, in addition to being highly time dependent. A generic ΛCDM collision model, where a bullet subcluster with concentration c = 7.2 merges with a parent cluster with concentration c = 3 on a zero-energy orbit, reproduces all the main observational features seen in 1E0657-56 with good

  18. Call Center ist nicht gleich Call Center

    OpenAIRE

    Baumgartner, Marc; Udris, Ivars

    2005-01-01

    Untersuchungen in 14 Schweizer Call Centers erbrachten vier Call Center-Typen, die sich hinsichtlich Arbeitstätigkeiten und Kommunikationsrichtung voneinander unterscheiden: (a) Beratungs- und Beschwerdemanagement, (b) Informationsmanagement, (c) Auftragsmanagement und (d) Kunden- und Kampagnenmanagement. Dies hat auch Auswirkungen auf die Personalstruktur, -selektion und -entwicklung der Call Center. Es wird der Frage nachgegangen, welche Kompetenzanforderungen in den unterschiedlichen Call ...

  19. PRELIMINARY STUDY OF A NOVEL HUMAN PAPILLOMAVIRUS TYPE 16 L1/E6-E7 CHIMERIC RECOMBINANT DNA VACCINE

    Institute of Scientific and Technical Information of China (English)

    郑瑾; 马军; 张福萍; 杨筱凤; 董小平; 司履生; 王一理

    2004-01-01

    Objective Preparations of HPV16 L1/E6 and L1/E7 prophylactic and therapeutic DNA vaccines. Methods The nucleotides within HPV16 E6 and E7 genes, which are responsible for viral transforming activity, were mutated by mage primer site-directed mutagenesis method. The correctly mutated E6 and E7 fragments were separately cloned into an eukaryotic expression vector pVAX1, together with HPV16 L1 gene, generating chimeric recombinants plasmids 1MpVAX1-L1E6, 2MpVAX1-L1E6, 1MpVAX1-L1E7, 2MpVAX1-L1E7 and 3MpVAX1-L1E7. CHO cells were transiently transfected with the individual DNA vaccines by calcium phosphate method. Target protein expressions in the extracts of the transfected cell lines were measured by ELISA and immunohistochemistry, with HPV16 L1 and E6 specific monoclonal antibodies. Results ELISA assays showed the P/N ratios in the cell extracts transfected with L1E6 and L1E7 plasmids were more than 2.1. Immunohistochemistry revealed brownish precipitant signal in cytoplasm and nuclei of the transfected cells. Conclusion Successful constructions of prophylactic and therapeutic DNA vaccine plasmids lay solid foundation for future animal experiment and clinical trial.

  20. M1-E2 mixing ratios of gamma-ground transitions in 168Er

    International Nuclear Information System (INIS)

    The L subshell ratios of four γ-g transitions in 168Er have been measured with the high resolution, iron, β-spectrometer at the Institut Laue-Langevin. The reduced M1-E2 mixing ratios are not consistent with the values predicted by Warner on the basis of IBA-1. It may be possible to explain the results in IBA-2 in terms of the ΔK = 1 mixing of the gamma-band and the pure antisymmetric states such as the 1+ isovector mode

  1. 1E Qualification of Electrical Equipment - Requirement for Safety Nuclear Power Plants

    International Nuclear Information System (INIS)

    The paper presents the qualification methods of the safety related equipment according to the safety class 1E. There are presented the qualification principles, procedure and documents, emphasis being laid on the qualification approach by type tests. This approach assumes the equipment test under both normal and accident conditions (design basis events) simulating the operational conditions and covers the largest part of electrical equipment from a nuclear power plant.The safety related equipment is to be qualified is subjected to a sequential test that will be detailed in the paper. (author)

  2. Transplant Center Search Form

    Science.gov (United States)

    ... Your Story Give Us Feedback - A + A Transplant Center Search Form Welcome to the Blood & Marrow Transplant ... centers for patients with a particular disease. Transplant Center login Username: * Password: * Request new password Join BMT ...

  3. Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description

    Directory of Open Access Journals (Sweden)

    Rodrigo Pinheiro Araldi

    2015-01-01

    Full Text Available Bovine papillomavirus (BPV is considered a useful model to study HPV oncogenic process. BPV interacts with the host chromatin, resulting in DNA damage, which is attributed to E5, E6, and E7 viral oncoproteins activity. However, the oncogenic mechanisms of BPV E6 oncoprotein per se remain unknown. This study aimed to evaluate the mutagenic potential of Bos taurus papillomavirus type 1 (BPV-1 E6 recombinant oncoprotein by the cytokinesis-block micronucleus assay (CBMNA and comet assay (CA. Peripheral blood samples of five calves were collected. Samples were subjected to molecular diagnosis, which did not reveal presence of BPV sequences. Samples were treated with 1 μg/mL of BPV-1 E6 oncoprotein and 50 μg/mL of cyclophosphamide (positive control. Negative controls were not submitted to any treatment. The samples were submitted to the CBMNA and CA. The results showed that BPV E6 oncoprotein induces clastogenesis per se, which is indicative of genomic instability. These results allowed better understanding the mechanism of cancer promotion associated with the BPV E6 oncoprotein and revealed that this oncoprotein can induce carcinogenesis per se. E6 recombinant oncoprotein has been suggested as a possible vaccine candidate. Results pointed out that BPV E6 recombinant oncoprotein modifications are required to use it as vaccine.

  4. Proposal to Search for Magnetically Charged Particles with Magnetic Charge 1e

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, Michael K. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Fryberger, David [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-11-02

    A model for composite elementary Standard Model (SM) particles based upon magnetically bound vorton pairs, we briefly introduce here, predicts the existence of a complete family of magnetically charged particles, as well as their neutral isotopic partners (all counterparts to the SM elementary particles), in which the lowest mass (charged) particle would be an electrically neutral stable lepton, but which carries a magnetic charge equivalent to 1e. This new particle, which we call a magneticon (a counterpart to the electron) would be pair produced at all e+e- colliders at an Ecm above twice its mass. In addition, PP and PPbar colliders should also be able to produce these new particles through the Drell-Yan process. To our knowledge, no monopole search experiment has been sensitive to such a low-charged magnetic monopole above a particle mass of about 5 GeV/c2. Hence, we propose that a search for such a stable particle of magnetic charge 1e should be undertaken. We have taken the ATLAS detector at the LHC as an example in which this search might be done. To this end, we modeled the magnetic fields and muon trigger chambers of this detector. We show results from a simple Monte Carlo simulation program to indicate how these particles might look in the detector and describe how one might search for these new particles in the ATLAS data stream.

  5. Evidence for the magnetar nature of 1E 161348-5055 in RCW 103

    CERN Document Server

    D'Aì, A; Burrows, D N; Lien, A Y; Kann, D A; Campana, S; Maselli, A; Romano, P; Cusumano, G; La Parola, V; Beardmore, A P; Cenko, B; De Pasquale, M; Gehrels, N; Greiner, J; Kennea, J A; Klose, S; Melandri, A; Nousek, J A; Osborne, J P; Sbarufatti, B; Siegel, M H; Schady, P; Tagliaferri, G; Yates, R; Zane, S

    2016-01-01

    We report on the detection of a bright, short, hard X-ray burst coming from the supernova remnant RCW 103 on 2016 June 22 caught by the \\emph{Swift}/BAT monitor, and on a follow-up campaign made with \\emph{Swift}/XRT and the optical/NIR GROND detector. The characteristics of the flash, such as duration and spectral shape, are consistent with typical bursts observed from soft gamma repeaters. The BAT error circle at 68\\% confidence range encloses the point-like X-ray source at the centre of the nebula, 1E 161348-5055. Its nature has been long debated because of a periodicity of 6.67 hr in X-rays, that could indicate either an extremely slow pulsating neutron star, or an orbital period of a very compact X-ray binary system. We found that the soft X-ray emission of 1E 161348-5055, 20 minutes earlier than the BAT detected burst, was already a factor $\\sim$ 100 higher with respect to the past two years, indicating that an outburst had started. By comparing the spectral and timing characteristics of the source in t...

  6. Womens Business Center

    Data.gov (United States)

    Small Business Administration — Women's Business Centers (WBCs) represent a national network of nearly 100 educational centers throughout the United States and its territories, which are designed...

  7. Student Success Center Toolkit

    Science.gov (United States)

    Jobs For the Future, 2014

    2014-01-01

    "Student Success Center Toolkit" is a compilation of materials organized to assist Student Success Center directors as they staff, launch, operate, and sustain Centers. The toolkit features materials created and used by existing Centers, such as staffing and budgeting templates, launch materials, sample meeting agendas, and fundraising…

  8. Toward Selective Drug Development for the Human 5-Hydroxytryptamine 1E Receptor: A Comparison of 5-Hydroxytryptamine 1E and 1F Receptor Structure-Affinity RelationshipsS⃞

    OpenAIRE

    Klein, Michael T.; Dukat, Małgorzata; Glennon, Richard A.; Teitler, Milt

    2011-01-01

    The 5-hydroxytryptamine (5-HT) 1E receptor is highly expressed in the human frontal cortex and hippocampus, and this distribution suggests the function of 5-HT1E receptors might be linked to memory. To test this hypothesis, behavioral experiments are needed. Because rats and mice lack a 5-HT1E receptor gene, knockout strategies cannot be used to elucidate this receptor's functions. Thus, selective pharmacological tools must be developed. The tryptamine-related agonist BRL54443 [5-hydroxy-3-(1...

  9. Human Papillomavirus Type 1 E1^E4 Protein Is a Potent Inhibitor of the Serine-Arginine (SR) Protein Kinase SRPK1 and Inhibits Phosphorylation of Host SR Proteins and of the Viral Transcription and Replication Regulator E2

    OpenAIRE

    Prescott, Emma L.; Brimacombe, Claire L.; Hartley, Margaret; Bell, Ian; Graham, Sheila; Roberts, Sally

    2014-01-01

    The serine-arginine-specific protein kinase SRPK1 is a common binding partner of the E1^E4 protein of diverse human papillomavirus types. We show here for the first time that the interaction between HPV1 E1^E4 and SRPK1 leads to potent inhibition of SRPK1 phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism, including pre-mRNA processing, mRNA export, and translation. Furthermore, we show that SRPK1 phosphorylates serine residues of SR/RS dipeptide...

  10. Robinson-Schensted-Knuth Correspondence and Weak Polynomial Identities of M1,1(E)

    Institute of Scientific and Technical Information of China (English)

    Onofrio Mario Di Vincenzo; Roberto La Scala

    2005-01-01

    In this paper, it is proved that the ideal Iω of the weak polynomial identities of the superalgebra M1,1(E) is generated by the p roper polynomials [x1,x2, x3] and [x2,x1][xa,x1][x4, x1]. This is proved for any infinite field F of characteristic different a basis and the dimension of any multihomogeneous component of the quotient algebra B/(B ∩ Iw). We also compute the Hilbert series of this algebra. One of the main tools of this paper is a variant we found of the Robinson-Schensted-Knuth correspondence defined for single semistandard tableaux of double shape.

  11. E1, M1, E2 transition energies and probabilities of W$^{54+}$ ions

    CERN Document Server

    Ding, Xiao-bin; Liu, Jia-xin; Koike, Fumihiro; Murakami, Izumi; Kato, Daiji; Sakaue, Hiroyuki A; Nakamura, Nobuyuki; Dong, Chen-zhong

    2016-01-01

    A comprehensive theoretical study of the E1, M1, E2 transitions of Ca-like tungsten ions is presented. Using multi-configuration Dirac-Fock (MCDF) method with a restricted active space treatment, the wavelengths and probabilities of the M1 and E2 transitions between the multiplets of the ground state configuration ([Ne]3s$^{2}$3p$^{6}$3d$^{2}$) and of the E1 transitions between [Ne]3s$^{2}$3p$^{5}$3d$^{3}$ and [Ne]3s$^{2}$3p$^{6}$3d$^{2}$ have been calculated. The results are in reasonable agreement with available experimental data. The present E1 and M1 calculations are compared with previous theoretical values. For E2 transitions, the importance of electron correlation from 3s and 3p orbitals is pointed out. Several strong E1 transitions are predicted, which have potential advantage for plasma diagnostics.

  12. 1E 1740.7-2942 (the Great Annihilator) enters a low-intensity state

    NARCIS (Netherlands)

    E. Kuulkers; C. Ferrigno; M. Del Santo; A. Bazzano; J. Alfonso-Garzon; V. Beckmann; A.J. Bird; S. Brandt; J. Chenevez; T.J.L. Courvoisier; A. Domingo; K. Ebisawa; P.G. Jonker; P. Kretschmar; C.B. Markwardt; T. Oosterbroek; A. Paizis; K. Pottschmidt; C. Sanchez-Fernandez; R. Wijnands

    2012-01-01

    INTEGRAL has been monitoring the Galactic center region since the beginning of August 2012 during the Galactic bulge (GB) monitoring program (see ATel #438), the Target of Opportunity observations of Swift J174510.8-262411 (see ATel #4450), as well as during other observing programs. During the GB m

  13. Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing eRF1-eRF3 or eRF1-ABCE1

    Directory of Open Access Journals (Sweden)

    Anne Preis

    2014-07-01

    Full Text Available Termination and ribosome recycling are essential processes in translation. In eukaryotes, a stop codon in the ribosomal A site is decoded by a ternary complex consisting of release factors eRF1 and guanosine triphosphate (GTP-bound eRF3. After GTP hydrolysis, eRF3 dissociates, and ABCE1 can bind to eRF1-loaded ribosomes to stimulate peptide release and ribosomal subunit dissociation. Here, we present cryoelectron microscopic (cryo-EM structures of a pretermination complex containing eRF1-eRF3 and a termination/prerecycling complex containing eRF1-ABCE1. eRF1 undergoes drastic conformational changes: its central domain harboring the catalytically important GGQ loop is either packed against eRF3 or swung toward the peptidyl transferase center when bound to ABCE1. Additionally, in complex with eRF3, the N-terminal domain of eRF1 positions the conserved NIKS motif proximal to the stop codon, supporting its suggested role in decoding, yet it appears to be delocalized in the presence of ABCE1. These results suggest that stop codon decoding and peptide release can be uncoupled during termination.

  14. NuSTAR and XMM-Newton Observations of 1E1743.1-2843: Indications of a Neutron Star LMXB Nature of the Compact Object

    Science.gov (United States)

    Lotti, Simone; Natalucci, Lorenzo; Mori, Kaya; Baganoff, Frederick K.; Boggs, Steven E.; Christensen, Finn E.; Craig, William W.; Hailey, Charles J.; Harrison, Fiona A.; Hong, Jaesub; Krivonos, Roman A.; Rahoui, Farid; Stern, Daniel; Tomsick, John A.; Zhang, Shuo; Zhang, William W.

    2016-05-01

    We report on the results of NuSTAR and XMM-Newton observations of the persistent X-ray source 1E1743.1-2843, located in the Galactic Center region. The source was observed between 2012 September and October by NuSTAR and XMM-Newton, providing almost simultaneous observations in the hard and soft X-ray bands. The high X-ray luminosity points to the presence of an accreting compact object. We analyze the possibilities of this accreting compact object being either a neutron star (NS) or a black hole, and conclude that the joint XMM-Newton and NuSTAR spectrum from 0.3 to 40 keV fits a blackbody spectrum with {kT}˜ 1.8 {keV} emitted from a hot spot or an equatorial strip on an NS surface. This spectrum is thermally Comptonized by electrons with {{kT}}e˜ 4.6 {keV}. Accepting this NS hypothesis, we probe the low-mass X-ray binary (LMXB) or high-mass X-ray binary (HMXB) nature of the source. While the lack of Type-I bursts can be explained in the LMXB scenario, the absence of pulsations in the 2 mHz-49 Hz frequency range, the lack of eclipses and of an IR companion, and the lack of a {K}α line from neutral or moderately ionized iron strongly disfavor interpreting this source as a HMXB. We therefore conclude that 1E1743.1-2843 is most likely an NS-LMXB located beyond the Galactic Center. There is weak statistical evidence for a soft X-ray excess which may indicate thermal emission from an accretion disk. However, the disk normalization remains unconstrained due to the high hydrogen column density ({N}{{H}}˜ 1.6× {10}23 {{cm}}-2).

  15. NACA Aircraft on Lakebed - D-558-2, X-1B, and X-1E

    Science.gov (United States)

    1955-01-01

    Early NACA research aircraft on the lakebed at the High Speed Research Station in 1955: Left to right: X-1E, D-558-2, X-1B There were four versions of the original Bell X-1 rocket-powered research aircraft that flew at the NACA High-Speed Flight Research Station, Edwards, California. The bullet-shaped X-1 aircraft were built by Bell Aircraft Corporation, Buffalo, N.Y. for the U.S. Army Air Forces (after 1947, U.S. Air Force) and the National Advisory Committee for Aeronautics (NACA). The X-1 Program was originally designated the XS-1 for EXperimental Supersonic. The X-1's mission was to investigate the transonic speed range (speeds from just below to just above the speed of sound) and, if possible, to break the 'sound barrier.' Three different X-1s were built and designated: X-1-1, X-1-2 (later modified to become the X-1E), and X-1-3. The basic X-1 aircraft were flown by a large number of different pilots from 1946 to 1951. The X-1 Program not only proved that humans could go beyond the speed of sound, it reinforced the understanding that technological barriers could be overcome. The X-1s pioneered many structural and aerodynamic advances including extremely thin, yet extremely strong wing sections; supersonic fuselage configurations; control system requirements; powerplant compatibility; and cockpit environments. The X-1 aircraft were the first transonic-capable aircraft to use an all-moving stabilizer. The flights of the X-1s opened up a new era in aviation. The first X-1 was air-launched unpowered from a Boeing B-29 Superfortress on January 25, 1946. Powered flights began in December 1946. On October 14, 1947, the X-1-1, piloted by Air Force Captain Charles 'Chuck' Yeager, became the first aircraft to exceed the speed of sound, reaching about 700 miles per hour (Mach 1.06) and an altitude of 43,000 feet. The number 2 X-1 was modified and redesignated the X-1E. The modifications included adding a conventional canopy, an ejection seat, a low-pressure fuel system

  16. The Development of the Safety Related Valve Class 1E Electrical Motor, the Target and the Results

    International Nuclear Information System (INIS)

    The development of the safety related valves class 1E electric motor is described. The design implemented in order to satisfy the 1E requirements, and a way in which related 1E standards are addressed, are shown. The development was realized in three stages. In the first stage eight motorettes were made and the insulation system was tested. In the second stage the motor was produced in accordance with producer's prototype QA program. In the third stage part of the testing of the produced motor was made. The results of the testing, finished until now, show that produced motor, as well as similarly produced motors, is able to perform its safety function in the design bases accident conditions as requested by class 1E requirements. The rest of the testing (LOCA test) can be made on the same or similar motor in the future. (author)

  17. A1E reduces stemness and self-renewal in HPV 16-positive cervical cancer stem cells

    OpenAIRE

    Kwon, Taeho; Bak, Yesol; Ham, Sun-Young; Yu, Dae-Yeul; Yoon, Do-Young

    2016-01-01

    Background Cervical cancer is the second most common cancer in females. Recent reports have revealed the critical role of cervical cancer stem cells (CSCs) in tumorigenicity and metastasis. Previously we demonstrated that A1E exerts an anti-proliferative action, which inhibits the growth of cervical cancer cells. Methods A1E is composed of 11 oriental medicinal herbs. Cervical cancer cell culture, wund healing and invasion assay, flow cytometry, sheroid formation assay, and wstern blot assays...

  18. NuSTAR Observations of the Magnetar 1E 2259+586

    DEFF Research Database (Denmark)

    Vogel, Julia K.; Hascoet, Romain; Kaspi, Victoria M.;

    2014-01-01

    We report on new broad band spectral and temporal observations of the magnetar 1E 2259+586, which is located in the supernova remnant CTB 109. Our data were obtained simultaneously with the Nuclear Spectroscopic Telescope Array (NuSTAR) and Swift, and cover the energy range from 0.5-79 keV. We...... present pulse profiles in various energy bands and compare them to previous RXTE results. The NuSTAR data show pulsations above 20 keV for the first time and we report evidence that one of the pulses in the double-peaked pulse profile shifts position with energy. The pulsed fraction of the magnetar is...... shown to increase strongly with energy. Our spectral analysis reveals that the soft X-ray spectrum is well characterized by an absorbed double blackbody or blackbody plus power-law model in agreement with previous reports. Our new hard X-ray data, however, suggest that an additional component, such as a...

  19. NuSTAR Observations of the Magnetar 1E 2259+586

    CERN Document Server

    Vogel, Julia K; Kaspi, Victoria M; An, Hongjun; Archibald, Robert; Beloborodov, Andrei M; Boggs, Steven E; Christensen, Finn E; Craig, William W; Gotthelf, Eric V; Grefenstette, Brian W; Hailey, Charles J; Harrison, Fiona A; Kennea, Jamie A; Madsen, Kristin K; Pivovaroff, Michael J; Stern, Daniel; Zhang, William W

    2014-01-01

    We report on new broad band spectral and temporal observations of the magnetar 1E 2259+586, which is located in the supernova remnant CTB 109. Our data were obtained simultaneously with the Nuclear Spectroscopic Telescope Array (NuSTAR) and Swift, and cover the energy range from 0.5-79 keV. We present pulse profiles in various energy bands and compare them to previous RXTE results. The NuSTAR data show pulsations above 20 keV for the first time and we report evidence that one of the pulses in the double-peaked pulse profile shifts position with energy. The pulsed fraction of the magnetar is shown to increase strongly with energy. Our spectral analysis reveals that the soft X-ray spectrum is well characterized by an absorbed double-blackbody or blackbody plus power-law model in agreement with previous reports. Our new hard X-ray data, however, suggests that an additional component, such as a power-law, is needed to describe the NuSTAR and Swift spectrum. We also fit the data with the recently developed coronal...

  20. Deep NuSTAR and Swift Monitoring Observations of the Magnetar 1E 1841-045

    CERN Document Server

    An, Hongjun; Hascoet, Romain; Archibald, Anne M; Beardmore, Andy; Boggs, Steven E; Christensen, Finn E; Craig, William W; Gehrels, Niel; Hailey, Charles J; Harrison, Fiona A; Kennea, Jamie; Kouveliotou, Chryssa; Stern, Daniel; Younes, George; Zhang, William W

    2015-01-01

    We report on a 350-ks NuSTAR observation of the magnetar 1E 1841-045 taken in 2013 September. During the observation, NuSTAR detected six bursts of short duration, with $T_{90}<1$ s. An elevated level of emission tail is detected after the brightest burst, persisting for $\\sim$1 ks. The emission showed a power-law decay with a temporal index of 0.5 before returning to the persistent emission level. The long observation also provided detailed phase-resolved spectra of the persistent X-ray emission of the source. By comparing the persistent spectrum with that previously reported, we find that the source hard-band emission has been stable over approximately 10 years. The persistent hard X-ray emission is well fitted by a coronal outflow model, where $e^{+/-}$ pairs in the magnetosphere upscatter thermal X-rays. Our fit of phase-resolved spectra allowed us to estimate the angle between the rotational and magnetic dipole axes of the magnetar, $\\alpha_{mag}=0.25$, the twisted magnetic flux, $2.5\\times10^{26}\\rm ...

  1. Rates of E1, E2, M1, and M2 transitions in Ni II

    Science.gov (United States)

    Cassidy, C. M.; Hibbert, A.; Ramsbottom, C. A.

    2016-03-01

    Aims: We present rates for all E1, E2, M1, and M2 transitions among the 295 fine-structure levels of the configurations 3d9, 3d84s, 3d74s2, 3d84p, and 3d74s4p, determined through an extensive configuration interaction calculation. Methods: The CIV3 code developed by Hibbert and coworkers is used to determine for these levels configuration interaction wave functions with relativistic effects introduced through the Breit-Pauli approximation. Results: Two different sets of calculations have been undertaken with different 3d and 4d functions to ascertain the effect of such variation. The main body of the text includes a representative selection of data, chosen so that key points can be discussed. Some analysis to assess the accuracy of the present data has been undertaken, including comparison with earlier calculations and the more limited range of experimental determinations. The full set of transition data is given in the supplementary material as it is very extensive. Conclusions: We believe that the present transition data are the best currently available. Full Table 4 and Tables 5-8 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/587/A107

  2. The Swift/Fermi GRB 080928 from 1 eV to 150 keV

    CERN Document Server

    Rossi, A; Klose, S; Kann, D A; Rau, A; Krimm, H A; Jóhannesson, G; Panaitescu, A; Yuan, F; Ferrero, P; Krühler, T; Greiner, J; Schady, P; Pandey, S B; Amati, L; Afonso, P M J; Akerlof, C W; Arnold, L; Clemens, C; Filgas, R; Hartmann, D H; Yoldaş, A Küpcü; McBreen, S; McKay, T A; Guelbenzu, A Nicuesa; E., F Olivares; Paciesas, B; Rykoff, E S; Szokoly, G; Updike, A C; Yoldaş, A

    2010-01-01

    We present the results of a comprehensive study of the Gamma-Ray Burst 080928 and of its afterglow. GRB 080928 was a long burst detected by Swift/BAT and Fermi/GBM. It is one of the exceptional cases where optical emission was already detected when the GRB itself was still radiating in the gamma-ray band. For nearly 100 seconds simultaneous optical, X-ray and gamma-ray data provide a coverage of the spectral energy distribution of the transient source from about 1 eV to 150 keV. Here we analyze the prompt emission, constrain its spectral properties, and set lower limits on the initial Lorentz factor of the relativistic outflow. In particular, we show that the SED during the main prompt emission phase is in agreement with synchrotron radiation. We construct the optical/near-infrared light curve and the spectral energy distribution based on Swift/UVOT, ROTSE-IIIa (Australia) and GROND (La Silla) data and compare it to the X-ray light curve retrieved from the Swift/XRT repository. We show that its bumpy shape ca...

  3. NuSTAR OBSERVATIONS OF THE MAGNETAR 1E 2259+586

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, Julia K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hascoët, Romain [Columbia Univ., New York, NY (United States); Kaspi, Victoria M. [Univ. of Montreal, Quebec (Canada); An, Hongjun [Univ. of Montreal, Quebec (Canada); Archibald, Robert [Univ. of Montreal, Quebec (Canada); Beloborodov, Andrei M. [Columbia Univ., New York, NY (United States); Boggs, Steven E. [Univ. of California, Berkeley, CA (United States); Christensen, Finn E. [Technical Univ. of Denmark, Lyngby (Denmark); Craig, William W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gotthelf, Eric V. [Columbia Univ., New York, NY (United States); Grefenstette, Brian W. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Hailey, Charles J. [Columbia Univ., New York, NY (United States); Harrison, Fiona A. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Kennea, Jamie A. [Pennsylvania State Univ., State College, PA (United States); Madsen, Kristin K. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Pivovaroff, Michael J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Stern, Daniel [California Inst. of Technology (CalTech), Pasadena, CA (United States); Zhang, William W. [NASA Goddard Space Flight Center (GSFC), Greenbelt, MD (United States)

    2014-07-01

    We report on new broad band spectral and temporal observations of the magnetar 1E 2259+586, which is located in the supernova remnant CTB 109. Our data were obtained simultaneously with the Nuclear Spectroscopic Telescope Array (NuSTAR) and Swift, and cover the energy range from 0.5-79 keV. We present pulse profiles in various energy bands and compare them to previous RXTE results. The NuSTAR data show pulsations above 20 keV for the first time and we report evidence that one of the pulses in the double-peaked pulse profile shifts position with energy. The pulsed fraction of the magnetar is shown to increase strongly with energy. Our spectral analysis reveals that the soft X-ray spectrum is well characterized by an absorbed double blackbody or blackbody plus power-law model in agreement with previous reports. Our new hard X-ray data, however, suggest that an additional component, such as a power law, is needed to describe the NuSTAR and Swift spectrum. We also fit the data with the recently developed coronal outflow model by Beloborodov for hard X-ray emission from magnetars. The outflow from a ring on the magnetar surface is statistically preferred over outflow from a polar cap.

  4. Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivator.

    Science.gov (United States)

    Brokaw, J L; Blanco, M; McBride, A A

    1996-01-01

    The N-terminal domain of the bovine papillomavirus type 1 E2 protein is important for viral DNA replication, for transcriptional transactivation, and for interaction with the E1 protein. To determine which residues of this 200-amino-acid domain are important for these activities, single conservative amino acid substitutions have been generated in 17 residues that are invariant among all papillomavirus E2 proteins. The resulting mutated E2 proteins were tested for the ability to support viral DNA replication, activate transcription, and cooperatively bind to the origin of replication with the E1 protein. We identified five mutated proteins that were completely defective for transcriptional activation and either were defective or could support viral DNA replication at only low levels. However, several of these proteins could still interact efficiently with the E1 protein. In addition, we identified several mutated proteins that were unable to efficiently cooperatively bind to the origin with the E1 protein. Although a number of the mutated proteins demonstrated wild-type activity in all of the functions tested, only 3 out of 17 mutated viral genomes were able to induce foci in a C127 focus formation assay when the mutations were generated in the background of the entire bovine papillomavirus type 1 genome. This finding suggests that the E2 protein may have additional activities that are important for the viral life cycle. PMID:8523530

  5. NuSTAR observations of magnetar 1E 1841-045

    CERN Document Server

    An, Hongjun; Kaspi, Victoria M; Beloborodov, Andrei M; Dufour, Francois; Gotthelf, Eric V; Archibald, Robert; Bachetti, Matteo; Boggs, Steven E; Christensen, Finn E; Craig, William W; Greffenstette, Brian W; Hailey, Charles J; Harrison, Fiona A; Kitaguchi, Takao; Kouveliotou, Chryssa; Madsen, Kristin K; Markwardt, Craig B; Stern, Daniel; Vogel, Julia K; Zhang, William W

    2013-01-01

    We report new spectral and temporal observations of the magnetar 1E 1841-045 in the Kes 73 supernova remnant obtained with the Nuclear Spectroscopic Telescope Array (NuSTAR). Combined with new Swift and archival XMM-Newton and Chandra observations, the phase-averaged spectrum is well characterized by a blackbody plus double power-law model, in agreement with previous, multi-mission X-ray results. However, we are unable to reproduce the spectral results reported using Suzaku observations. The pulsed fraction of the source is found to increase with photon energy. The measured rms pulsed fraction is ~12% and ~17% at ~20 keV and ~50 keV, respectively. We detect a new feature in the 24--35 keV band pulse profile that is uniquely double-peaked. This feature may be associated with a possible absorption or emission feature in the phase-resolved spectrum. We fit the X-ray data using the recently developed electron-positron outflow model of Beloborodov (2013) for the hard X-ray emission from magnetars. This produces a ...

  6. The X-ray Bursts from the Magnetar Candidate 1E 2259+586

    CERN Document Server

    Gavriil, F P; Woods, P M; Gavriil, Fotis P.; Kaspi, Victoria M.; Woods, Peter M.

    2004-01-01

    We present a statistical analysis of the X-ray bursts observed from the 2002 June 18 outburst of the Anomalous X-ray Pulsar (AXP) 1E 2259+586, observed with the Proportional Counter Array aboard the Rossi X-ray Timing Explorer. We show that the properties of these bursts are similar to those of Soft Gamma-Repeaters (SGRs). The similarities we find are: the burst durations follow a log-normal distribution which peaks at 99 ms, the differential burst fluence distribution is well described by a power law of index -1.7, the burst fluences are positively correlated with the burst durations, the distribution of waiting times is well described by a log-normal distribution of mean 47 s, and the bursts are generally asymmetric with faster rise than fall times. However, we find several quantitative differences between the AXP and SGR bursts. Specifically, there is a correlation of burst phase with pulsed intensity, the AXP bursts we observed exhibit a wider range of durations, the correlation between burst fluence and ...

  7. The Cluster-Merger Shock in 1E 0657-56: Faster than the Speeding Bullet?

    CERN Document Server

    Milosavljevic, M; Nagai, D; Nakar, E; Shapiro, P R; Milosavljevic, Milos; Koda, Jun; Nagai, Daisuke; Nakar, Ehud; Shapiro, Paul R.

    2007-01-01

    Shock waves driven in the intergalactic medium during the merging of galaxy clusters have been observed in X-ray imaging and spectroscopy. Fluid motions inferred from the shock strength and morphology can be compared to the cold dark matter (CDM) distribution inferred from gravitational lensing. A detailed reconstruction of the CDM kinematics, however, must take into account the nontrivial response of the fluid intracluster medium to the collisionless CDM motions. We have carried out two-dimensional simulations of gas dynamics in cluster collisions. We analyze the relative motion of the clusters, the bow shock wave, and the contact discontinuity and relate these to X-ray data. We focus on the "bullet cluster," 1E 0657-56, a near head-on collision of unequal-mass clusters, for which the gas density and temperature jumps across the prominent bow shock imply a high shock velocity 4,700 km/s. The velocity of the fluid shock has been widely interpreted as the relative velocity of the CDM components. This need not ...

  8. The Cluster-Merger Shock in 1E 0657-56

    CERN Document Server

    Koda, Jun; Shapiro, Paul R; Nagai, Daisuke; Nakar, Ehud

    2008-01-01

    The merging galaxy cluster 1E 0657-56, known as the "bullet cluster," is one of the hottest clusters known. The X-ray emitting plasma exhibits bow-shock-like temperature and density jumps. The segregation of this plasma from the peaks of the mass distribution determined by gravitational lensing has been interpreted as a direct proof of collisionless dark matter. If the high shock speed inferred from the shock jump conditions equals the relative speed of the merging CDM halos, however, this merger is predicted to be such a rare event in a LCDM universe that observing it presents a possible conflict with the LCDM model. We examined this question using high resolution, 2D simulations of gas dynamics in cluster collisions to analyze the relative motion of the clusters, the bow shock, and the contact discontinuity, and relate these to the X-ray data for the bullet cluster. We find that the velocity of the fluid shock need not equal the relative velocity of the CDM components. An illustrative simulation finds that ...

  9. A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

    Science.gov (United States)

    Mulder, Monique P C; Witting, Katharina; Berlin, Ilana; Pruneda, Jonathan N; Wu, Kuen-Phon; Chang, Jer-Gung; Merkx, Remco; Bialas, Johanna; Groettrup, Marcus; Vertegaal, Alfred C O; Schulman, Brenda A; Komander, David; Neefjes, Jacques; El Oualid, Farid; Ovaa, Huib

    2016-07-01

    Post-translational modifications of proteins with ubiquitin (Ub) and ubiquitin-like modifiers (Ubls), orchestrated by a cascade of specialized E1, E2 and E3 enzymes, control a wide range of cellular processes. To monitor catalysis along these complex reaction pathways, we developed a cascading activity-based probe, UbDha. Similarly to the native Ub, upon ATP-dependent activation by the E1, UbDha can travel downstream to the E2 (and subsequently E3) enzymes through sequential trans-thioesterifications. Unlike the native Ub, at each step along the cascade, UbDha has the option to react irreversibly with active site cysteine residues of target enzymes, thus enabling their detection. We show that our cascading probe 'hops' and 'traps' catalytically active Ub-modifying enzymes (but not their substrates) by a mechanism diversifiable to Ubls. Our founder methodology, amenable to structural studies, proteome-wide profiling and monitoring of enzymatic activity in living cells, presents novel and versatile tools to interrogate Ub and Ubl cascades. PMID:27182664

  10. 1-eV GaInNAs solar cells for ultrahigh-frequency multijunction devices

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, D.J.; Geisz, J.F.; Kurtz, S.R.; Olson, J.M. [National Renewable Energy Lab., Golden, CO (United States)

    1998-09-01

    The authors demonstrate working prototypes of a GaInNAs-based solar cell lattice-matched to GaAs with photoresponse down to 1 eV. This device is intended for use as the third junction of future-generation ultrahigh-efficiency three- and four-junction devices. Under the AM1.5 direct spectrum with all the light higher in energy than the GaAs band gap filtered out, the prototypes have open-circuit voltages ranging from 0.35 to 0.44 V, short-circuit currents of 1.8 mA/cm{sup 2}, and fill factors from 61--66%. The short-circuit currents are of principal concern: the internal quantum efficiencies rise only to about 0.2. The authors discuss the short diffusion lengths which are the reason for this low photocurrent. As a partial workaround for the poor diffusion lengths, they demonstrate a depletion-width-enhanced variation of one of the prototype devices that grades off decreased voltage for increased photocurrent, with a short-circuit current of 6.5 mA/cm{sup 2} and an open-circuit voltage of 0.29 V.

  11. AKT1E17K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer

    Science.gov (United States)

    Malanga, Donatella; Belmonte, Stefania; Colelli, Fabiana; Scarfò, Marzia; De Marco, Carmela; Oliveira, Duarte Mendes; Mirante, Teresa; Camastra, Caterina; Gagliardi, Monica; Rizzuto, Antonia; Mignogna, Chiara; Paciello, Orlando; Papparella, Serenella; Fagman, Henrik; Viglietto, Giuseppe

    2016-01-01

    The hotspot AKT1E17K mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6–2% of human lung cancers. Recently, we have demonstrated that AKT1E17K transforms immortalized human bronchial cells. Here by use of a transgenic Cre-inducible murine strain in the wild type Rosa26 (R26) locus (R26-AKT1E17K mice) we demonstrate that AKT1E17K is a bona-fide oncogene and plays a role in the development of lung cancer in vivo. In fact, we report that mutant AKT1E17K induces bronchial and/or bronchiolar hyperplastic lesions in murine lung epithelium, which progress to frank carcinoma at very low frequency, and accelerates tumor formation induced by chemical carcinogens. In conclusion, AKT1E17K induces hyperplasia of mouse lung epithelium in vivo and cooperates with urethane to induce the fully malignant phenotype. PMID:26859676

  12. Alzheimer's Disease Research Centers

    Science.gov (United States)

    ... Plan National Alzheimer's Project Act (NAPA) About ADEAR Alzheimer's Disease Research Centers The National Institute on Aging ... Repository for Alzheimer's Disease ADC Directory Arizona Arizona Alzheimer’s Disease Center/Sun Health Research Institute Eric Reiman, ...

  13. New Mexico Convention Centers

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset provides an initial version of the locations of convention centers in New Mexico, in point form, with limited attributes, compiled using available data...

  14. Day Care Centers

    Data.gov (United States)

    Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

  15. NIH Clinical Centers

    Data.gov (United States)

    Federal Laboratory Consortium — The NIH Clinical Center consists of two main facilities: The Mark O. Hatfield Clinical Research Center, which opened in 2005, houses inpatient units, day hospitals,...

  16. Tornadoes: A Center Approach.

    Science.gov (United States)

    Christman-Rothlein, Liz; Meinbach, Anita M.

    1981-01-01

    Information is given on how to put together a learning center. Discusses information and activity packets for a complete learning center on tornadoes including objectives, directions, materials, photographs of physical arrangements, and posttest. (DC)

  17. Center for Functional Nanomaterials

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Functional Nanomaterials (CFN) explores the unique properties of materials and processes at the nanoscale. The CFN is a user-oriented research center...

  18. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Safety Education Centers OnSafety Blog Neighborhood Safety Network Community Outreach Resource Center CO Poster Contest Toy Recall ... of the external site as its information collection practices may differ from ours. Linking to this external ...

  19. America's Blood Centers

    Science.gov (United States)

    ... or less. Please donate now! Full Stoplight Report America's Blood Centers is... FEATURED TODAY Support the Foundation ... purchase will be donated to the Foundation for America's Blood Centers! Simply Click Here! "We Are" This ...

  20. Hydrologic Engineering Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

  1. RSW Cell Centered Grids

    Data.gov (United States)

    National Aeronautics and Space Administration — New cell centered grids are generated to complement the node-centered ones uploaded. Six tarballs containing the coarse, medium, and fine mixed-element and pure...

  2. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Home / Safety Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon monoxide, also known as CO, is called the "Invisible ...

  3. BKG Data Center

    Science.gov (United States)

    Thorandt, Volkmar; Wojdziak, Reiner

    2013-01-01

    This report summarizes the activities and background information of the IVS Data Center for the year 2012. Included is information about functions, structure, technical equipment, and staff members of the BKG Data Center.

  4. ACTS data center

    Science.gov (United States)

    Syed, Ali; Vogel, Wolfhard J.

    1993-01-01

    Viewgraphs on ACTS Data Center status report are included. Topics covered include: ACTS Data Center Functions; data flow overview; PPD flow; RAW data flow; data compression; PPD distribution; RAW Data Archival; PPD Audit; and data analysis.

  5. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon monoxide, also known ... Install one and check its batteries regularly. View Information About CO Alarms Other CO Topics Safety Tips ...

  6. National Farm Medicine Center

    Science.gov (United States)

    ... Staff Agricultural Health and Safety Core Units Children's Center Cultivate Newsletter Journal of Agromedicine Milestones Auction of ... Farm Medicine, Rural Health & Safety National Farm Medicine Center Established in 1981 in response to occupational health ...

  7. Transplant Center Directory

    Science.gov (United States)

    ... mission. Learn more. My Account News Search Transplant Center Search Use the tools below to find a ... or enter your diagnosis to search for transplant centers. Select state(s) (optional) Enter diagnosis (optional) Please select ...

  8. NIST Diffusion Data Center

    Science.gov (United States)

    NIST Diffusion Data Center (Web, free access)   The NIST Diffusion Data Center is a collection of over 14,100 international papers, theses, and government reports on diffusion published before 1980.

  9. Center of buoyancy definition

    International Nuclear Information System (INIS)

    The center of buoyancy of an arbitrary shaped body is defined in analogy to the center of gravity. The definitions of the buoyant force and center of buoyancy in terms of integrals over the area of the body are converted to volume integrals and shown to have simple intuitive interpretations

  10. Data center cooling method

    Science.gov (United States)

    Chainer, Timothy J.; Dang, Hien P.; Parida, Pritish R.; Schultz, Mark D.; Sharma, Arun

    2015-08-11

    A method aspect for removing heat from a data center may use liquid coolant cooled without vapor compression refrigeration on a liquid cooled information technology equipment rack. The method may also include regulating liquid coolant flow to the data center through a range of liquid coolant flow values with a controller-apparatus based upon information technology equipment temperature threshold of the data center.

  11. Expression and identification of the ADF-linker-3-1E gene of Eimeria acervulina of chicken.

    Science.gov (United States)

    Yuelan, Zhao; Yiwei, Liu; Liyuan, Liu; Yue, Zhao; Wenbo, Cao; Yongzhan, Bao; Jianhua, Qin

    2016-04-01

    Coccidiosis is a widely distributed disease with higher mortality and morbidity, which is caused by several species of protozoan parasites belonging to the genus Eimeria and recognized as a serious challenge for the poultry industry. This research was conducted to construct the recombinant plasmid pET32a(+)-ADF-linker-3-1E of Eimeria acervulina (E. acervulina) of the chicken and test the bioactivity of the ADF-linker-3-1E protein. The ADF-linker-3-1E gene of E. acervulina of the chicken was cloned by splicing by overlap extension by the polymerase chain reaction (SOE-PCR) and then inserted into the pET32a(+) to construct the recombinant plasmid pET32a(+)-ADF-linker-3-1E. The recombinant plasmid was transformed into Escherichia coli Rosetta (DE3) competent cells and then induced by IPTG (0.6 mmol/L). The expressed product in the culture medium was identified by the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The bioactivity of the ADF-linker-3-1E protein was tested by Western blotting. The result showed that the amplified ADF-linker-3-1E gene was about 1346 bp. The PCR amplification with the recombinant plasmid pET-32a(+)-ADF-linker-3-1E as a template resulted in a special band of 1346 bp. The digested products resulted in two fragments of 1346 bp target fragment and 5.9 kb pET-32a(+)-vector fragment. The results indicated that the ADF-linker3-1E gene was successfully inserted into the pET-32a(+)-vector. The expressed products in the culture medium resulted in a single band of approximately 54.8 kDa by SDS-PAGE. Western blotting analysis indicated that the recombinant protein could be reacted specifically with His-Tag(2A8) Mouse mAb. This study indicated that the ADF-linker-3-1E protein with good bioactivity was successfully obtained, which laid a foundation for the exploitation of the nuclear vaccine by using the ADF-linker-3-1E protein. PMID:26767375

  12. The Swift/Fermi GRB 080928 from 1 eV to 150 keV

    Science.gov (United States)

    Sonbas, Eda; Rossi, A.; Schulze, S.; Klose, S.; Kann, D. A.; Ferrero, P.; NicuesaGuelbenzu, A.; Rau, A.; Kruehler, T.; Greiner, J.; Schady, P.; Afonso, P. M. J.; Clemens, C.; Filgas, R.; KuepcuYoldas, A.; McBreen, S.; Olivares, F.; Szokoly, G.; Yoldas, A.; Krimm, H. A.; Johannesson, G.; Panaitescu, A.; Yuan, F.; Pandey, S. B.; Akerlof, C. W.

    2010-01-01

    We present the results of a comprehensive study of the Gamma-Ray Burst 080928 and of its afterglow. GRB 08092 was a long burst detected by Swift/BAT and Fermi/GBM, It is one of the exceptional cases where optical emission was already detected when the GRB itself was still radiating in the gamma-ray band. for nearly 100 seconds simultaneous optical X-ray and gamma-ray data provide a coverage of the spectral energy distribution of the transient source from about 1 eV to 150 keV. Here we analyze the prompt emission, constrain its spectral propertIes. and set lower limits on the initial Lorentz factor of the relativistic outflow, In particular. we show that the SED during the main prompt emission phase is in agreement with synchrotron radiation. We construct the optical/near-infrared light curve and the spectral energy distribution based on Swift/UVOT. ROTSE-Illa (Australia) and GROND (La Silla) data and compare it to the X-ray light curve retrieved from the Swift/XRT repository. We show that its bumpy shape can be modeled by multiple energy injections into the forward shock. Furthermore, we provide evidence that the temporal and spectral evolution of the first strong flare seen in the early X-ray light curve can be explained by large-angle emission. Finally, we report on the results of our search for the GRB host galaxy, for which only a deep upper limit can be provided.

  13. Analysis of chromatin attachment and partitioning functions of bovine papillomavirus type 1 E2 protein.

    Science.gov (United States)

    Abroi, Aare; Ilves, Ivar; Kivi, Sirje; Ustav, Mart

    2004-02-01

    Recent studies have suggested that the tethering of viral genomes to host cell chromosomes could provide one of the ways to achieve their nuclear retention and partitioning during extrachromosomal maintenance in dividing cells. The data we present here provide firm evidence that the partitioning of the bovine papillomavirus type 1 (BPV1) genome is dependent on the chromatin attachment process mediated by viral E2 protein and its multiple binding sites. On the other hand, the attachment of E2 and the E2-mediated tethering of reporter plasmids to host chromosomes are not necessarily sufficient for efficient partitioning, suggesting that additional E2-dependent activities might be involved in the latter process. The activity of E2 protein in chromatin attachment and partitioning is more sensitive to the point mutations in the N-terminal domain than its transactivation and replication initiation functions. Therefore, at least part of the interactions of the E2 N-terminal domain with its targets during the chromatin attachment and partitioning processes are likely to involve specific receptors not involved in transactivation and replication activities of the protein. The mutational analysis also indicates that the binding of E2 to chromatin is not achieved through interaction of linear N-terminal subsequences of the E2 protein with putative receptors. Instead, the composite surface elements of the N-terminal domain build up the receptor-binding surface of E2. In this regard, the interaction of BPV1 E2 with its chromosomal targets clearly differs from the interactions of LANA1 protein from Kaposi's sarcoma-associated human herpesvirus and EBNA1 from Epstein-Barr virus with their specific receptors. PMID:14747575

  14. CSNK1E/CTNNB1 Are Synthetic Lethal To TP53 in Colorectal Cancer and Are Markers for Prognosis

    Directory of Open Access Journals (Sweden)

    Khong-Loon Tiong

    2014-05-01

    Full Text Available Two genes are called synthetic lethal (SL if their simultaneous mutations lead to cell death, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill cancer cells specifically, but leave normal cells intact. We present an integrated approach to uncovering SL pairs in colorectal cancer (CRC. Screening verified SL pairs using microarray gene expression data of cancerous and normal tissues, we first identified potential functionally relevant (simultaneously differentially expressed gene pairs. From the top-ranked pairs, ~20 genes were chosen for immunohistochemistry (IHC staining in 171 CRC patients. To find novel SL pairs, all 169 combined pairs from the individual IHC were synergistically correlated to five clinicopathological features, e.g. overall survival. Of the 11 predicted SL pairs, MSH2-POLB and CSNK1E-MYC were consistent with literature, and we validated the top two pairs, CSNK1E-TP53 and CTNNB1-TP53 using RNAi knockdown and small molecule inhibitors of CSNK1E in isogenic HCT-116 and RKO cells. Furthermore, synthetic lethality of CSNK1E and TP53 was verified in mouse model. Importantly, multivariate analysis revealed that CSNK1E-P53, CTNNB1-P53, MSH2-RB1, and BRCA1-WNT5A were independent prognosis markers from stage, with CSNK1E-P53 applicable to early-stage and the remaining three throughout all stages. Our findings suggest that CSNK1E is a promising target for TP53-mutant CRC patients which constitute ~40% to 50% of patients, while to date safety regarding inhibition of TP53 is controversial. Thus the integrated approach is useful in finding novel SL pairs for cancer therapeutics, and it is readily accessible and applicable to other cancers.

  15. Cloning, sequence analysis, and expression of the genes encoding lytic functions of Bacteriophage phi g1e.

    Science.gov (United States)

    Oki, M; Kakikawa, M; Yamada, K; Taketo, A; Kodaira, K I

    1996-10-17

    The lysis genes of a Lactobacillus phage phi g1e were cloned, sequenced, and expressed in Escherichia coli. Nucleotide sequencing of a 3813-bp phi g1e DNA revealed five successive open reading frames (ORF), Rorf50, Rorf118, hol, and lys and Rorf175, in the same DNA strand. By comparative analysis of the DNA sequence, the putative hol product (holin) has an estimated molecular weight is 14.2 kDa, and contains two potential transmembrane helices and highly charged N- and C-termini, resembling predicted holins (which are thought to be a cytoplasmic membrane-disrupting protein) encoded by other phages such as mv1 from Lactobacillus bulgaricus, phi adh from Lactobacillus gasseri, as well as monocins from Listeria. On the other hand, the putative phi g1e lys product (lysin) of 48.4 kDa shows significant similarity with presumed muramidase, known as a cell wall peptidoglycandegrading enzyme, encoded by the Lactobacillus phage mv1 and phi adh, the Lactococcus lactis phage phi LC3, and the Streptococcus pneumoniae phages Cp-1, Cp-7 and Cp-9. When expressed in E. coli, the phi g1e lysin and/or holin decreased the cell turbidity significantly, suggesting that the phi g1e hol-lys system is involved in cytolytic process. PMID:8918256

  16. Analytic strong-coupling expansion in 1/e for the electron propagator without fermion loops in quantum electrodynamics

    International Nuclear Information System (INIS)

    Starting from the path-integral representation for the electron propagator without fermion loops in QED, we analytically investigate the strong-coupling behavior in an arbitrary background electromagnetic field through a series expansion in powers of 1/e. Contrary to the perturbation theory expansion in e the new series only contains positive powers of the derivative operator p. Due to infrared singularities in the path integral the series does not exist beyond the lowest orders, although one can build a systematic expansion in powers of p (not 1/e) which can be calculated up to any order. To handle infinities we regularize using a Pauli-Villars approach. The introduction of fermion loops would not correspond to higher orders in 1/e, so a priori our results are only pertinent to the sector of QED we have chosen. 17 refs., 1 fig

  17. Investigation of the {sup 1}E{sub 2g}{sup {minus}} states in cyclic polyenes

    Energy Technology Data Exchange (ETDEWEB)

    Bracken, P.; Cizek, J. [Univ. of Waterloo, Ontario (Canada)

    1995-03-05

    An analysis withing the one-dimensional Hubbard model of the {sup 1}E{sub 2g}{sup {minus}} type state in cyclic polyenes is reported. In terms of the resonance integral {beta}, a small {beta} analysis and asymptotic large {beta} analysis have been carried out. Energy as a function of {beta} has been calculated numerically, and a second state with {sup 1}E{sub 2g}{sup {minus}} symmetry has been found. Some missing information about the higher momentum state of this symmetry is provided. 15 refs., 4 tabs.

  18. Detailed atmosphere modelling for the neutron star 1E1207.4-5209: Evidence of Oxygen/Neon atmosphere

    OpenAIRE

    Mori, Kaya; Hailey, Charles J,

    2003-01-01

    We present a comprehensive investigation of the two broad absorption features observed in the X-ray spectrum of the neutron star 1E1207.4-5209 based on a recent analysis of the 260 ksec XMM-Newton data by Mori et al. 2005. Expanding on our earlier work (Hailey & Mori 2002) we have examined all previously proposed atmospheric models for 1E1207.4-5209. Using our atomic code, which rapidly solves Schrodinger's equation for arbitrary ion in strong magnetic field (Mori & Hailey 2002), we have syst...

  19. Relativistic Guiding Center Equations

    Energy Technology Data Exchange (ETDEWEB)

    White, R. B. [PPPL; Gobbin, M. [Euratom-ENEA Association

    2014-10-01

    In toroidal fusion devices it is relatively easy that electrons achieve relativistic velocities, so to simulate runaway electrons and other high energy phenomena a nonrelativistic guiding center formalism is not sufficient. Relativistic guiding center equations including flute mode time dependent field perturbations are derived. The same variables as used in a previous nonrelativistic guiding center code are adopted, so that a straightforward modifications of those equations can produce a relativistic version.

  20. $Suzaku$ and $XMM-Newton$ observations of a newly-discovered early-stage cluster merger 1E2216.0-0401 and 1E2215.7-0404

    CERN Document Server

    Akamatsu, H; Shimwell, T W; Mernier, F; Mao, J; Urdampilleta, I; de Plaa, J; Röttgering, H J A; Kaastra, J S

    2016-01-01

    We present the results of $Suzaku$ and $XMM-Newton$ X-ray observations of the cluster pair 1E2216.0-0401 and 1E2215.7-0404. We discover an X-ray bridge between the clusters. $Suzaku$ and $XMM-Newton$ observations revealed that each cluster hosts gas with moderate temperature of $kT_{1E2216.0-0401}=$4.8$\\pm$0.1 keV and $kT_{1E2215.7-0404}=$5.8$\\pm$0.2 keV, respectively. On the other hand, the bridge region shows a remarkably high temperature ({\\it kT}=6.6$\\pm$0.5 keV). Furthermore, at the position of the bridge, we detected an enhancement in the wavelet-decomposed soft-band (0.5-4.0 keV) $XMM-Newton$ image at 3 sigma significance, this is most likely due to a compression of the intracluster medium (ICM) as a consequence of the merging activity. This X-ray intensity and temperature enhancement are not consistent with those expected from a late phase, but are in agreement with the predictions by numerical simulations of an early phase merger. From the temperature jump at the location of the bridge, the Mach numb...

  1. Airline Operation Center Workstation

    Data.gov (United States)

    Department of Transportation — The Airline Operation Center Workstation (AOC Workstation) represents equipment available to users of the National Airspace system, outside of the FAA, that enables...

  2. Chemical Security Analysis Center

    Data.gov (United States)

    Federal Laboratory Consortium — In 2006, by Presidential Directive, DHS established the Chemical Security Analysis Center (CSAC) to identify and assess chemical threats and vulnerabilities in the...

  3. Small Business Development Center

    Data.gov (United States)

    Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...

  4. Electron Microscopy Center (EMC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Electron Microscopy Center (EMC) at Argonne National Laboratory develops and maintains unique capabilities for electron beam characterization and applies those...

  5. Center for Deployment Psychology

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Deployment Psychology was developed to promote the education of psychologists and other behavioral health specialists about issues pertaining to the...

  6. Data Center at NICT

    Science.gov (United States)

    Ichikawa, Ryuichi; Sekido, Mamoru

    2013-01-01

    The Data Center at the National Institute of Information and Communications Technology (NICT) archives and releases the databases and analysis results processed at the Correlator and the Analysis Center at NICT. Regular VLBI sessions of the Key Stone Project VLBI Network were the primary objective of the Data Center. These regular sessions continued until the end of November 2001. In addition to the Key Stone Project VLBI sessions, NICT has been conducting geodetic VLBI sessions for various purposes, and these data are also archived and released by the Data Center.

  7. Test Control Center (TCC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Test Control Center (TCC) provides a consolidated facility for planning, coordinating, controlling, monitoring, and analyzing distributed test events. ,The TCC...

  8. Environmental Modeling Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  9. Funding Opportunity: Genomic Data Centers

    Science.gov (United States)

    Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

  10. HRSA: Find a Health Center

    Science.gov (United States)

    ... Please, try later. Close × Note To HRSA Health Centers: HRSA Health Center Grantees and Look-Alikes, please ... to save your changes. Close About HRSA Health Centers HRSA Health Centers care for you, even if ...

  11. Development of Thermal Stress Test Profile for Class 1E Equipment in Main Control Room of a Research Reactor

    International Nuclear Information System (INIS)

    The primary objective of an equipment qualification (EQ) is to demonstrate with reasonable assurance that Class 1E equipment for which a qualified life or condition has been established can perform its safety function without experiencing common-cause failures before, during, and after applicable design basis events (DBEs). For the environmental test of Class 1E equipment installed in the main control room (MCR) of a research reactor, the thermal stress test profile should be developed based on normal and abnormal environmental conditions of the MCR. A thermal stress test profile for Class 1E equipment located in the MCR of a research reactor is developed based on an engineering justification. A set of thermal stress test conditions including temperature, test duration, and number of test cycles is defined considering the specific characteristics of the targeted research reactor. The method used in this study can be applied to develop a thermal stress test profile used for the EQ test to qualify Class 1E equipment installed in the MCR of various research reactors

  12. Two distinct regions of the BPV1 E1 replication protein interact with the activation domain of E2.

    Science.gov (United States)

    Moscufo, N; Sverdrup, F; Breiding, D E; Androphy, E J

    1999-12-15

    Papillomavirus E1 and E2 proteins co-operation in viral DNA replication is mediated by protein-protein interactions that lead to formation of an E1-E2 complex. To identify the domains involved, portions of the two proteins were expressed as fusions to the DNA-binding protein LexA or the transactivation domain of VP16 and analyzed by the yeast two-hybrid system. The C-terminal 266 amino acids of BPV1 E1 (E1C266) interacted strongly with E2 in the yeast system and in a mammalian two-hybrid assay. VP16-E1C266 interacted with a region encompassing amino acids 1-200 of the transactivation domain of E2 that was fused to LexA. The interaction between E1 full length and E2 was clearly observed only when E1 was expressed as LexA-E1 chimera. In addition, we found that in the LexA context also the N-terminal region encompassing the first 340 amino acids of E1 (E1N340) interacted with E2 full length. The interactions of E1N340 and E1C266 with E2 were confirmed also by in vitro binding studies. These observations demonstrate that two distinct regions of E1 mediate the interaction with E2 in vivo. PMID:10581387

  13. The Relationship between Eating Disorders and ICAM-1, E-selection and Ghrelin Resting Level in Overweight People

    Directory of Open Access Journals (Sweden)

    Gholamreza Sharifi

    2014-11-01

    Full Text Available Introduction There is an agreement that eating disorder is related to psychological characteristics and on the other hand, level of ghrelin hormone, Intercellular adhesion molecule-1 (ICAM-1 and E-selection also change during eating disorders. We aimed to study the relationship between eating disorders and rest levels, ICAM-1, E-selection, and ghrelin hormone in obese people. Materials and Methods  In this quasi-experimental study, 120 obese men (25-30 years old were purposefully selected. Then the data about their eating disorders gathered with eating attitudes test (EAT-26 questionnaire. In the next phase in the rest condition and after overnight fasting, blood samples are collected for measurement of rest levels, ICAM-1, E-selection, and ghrelin hormone. Finally the data were analyzed with appropriate statistical tests in SPSS version 18. Results Mean and deviation of rest levels, ICAM-1, E-selection, and ghrelin hormone were respectively 3064.19, 61.5±19.7, and 2.5±1.5 and there was not any statistical significance relationship between eating disorders ICAM-1, E-selection, and ghrelin hormone in obese men (P

  14. A Burst and Simultaneous Short-Term Pulsed Flux Enhancement from the Magnetar Candidate 1E 1048.1-5937

    CERN Document Server

    Gavriil, F P; Woods, P M; Gavriil, Fotis P.; Kaspi, Victoria M.; Woods, Peter M.

    2006-01-01

    We report on the 2004 June 29 burst detected from the direction of the Anomalous X-ray Pulsar (AXP) 1E 1048.1-5937 using the Rossi X-ray Timing Explorer (RXTE). We find a simultaneous increase of ~3.5 times the quiescent value in the 2-10 keV pulsed flux of 1E 1048.1-5937 during the tail of the burst which identifies the AXP as the burst's origin. The burst was overall very similar to the two others reported from the direction of this source in 2001. The unambiguous identification of 1E 1048.1-5937 as the burster here confirms it was the origin of the 2001 bursts as well. The epoch of the burst peak was very close to the arrival time of 1E 1048.1-5937's pulse peak. The burst exhibited significant spectral evolution with the trend going from hard to soft. During the 11 days following the burst, the AXP was observed further with RXTE, XMM-Newton and Chandra. Pre- and post-burst observations revealed no change in the total flux or spectrum of the quiescent emission. Comparing all three bursts detected thus far f...

  15. NuSTAR Observations of X-ray Bursts from the Magnetar 1E 1048.1-5937

    DEFF Research Database (Denmark)

    An, Hongjun; Kaspi, Victoria M.; Beloborodov, Andrei M.;

    2014-01-01

    We report the detection of eight bright X-ray bursts from the 6.5 s magnetar 1E 1048.1–5937, during a 2013 July observation campaign with the Nuclear Spectroscopic Telescope Array. We study the morphological and spectral properties of these bursts and their evolution with time. The bursts resulte...

  16. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Consumers Businesses Contact CPSC Website Design Feedback Consumers: Español Businesses: Español , 中文 , Tiếng Việt Connect with Us : Twitter YouTube ... Safely Home / Safety Education / Safety Education Centers En Español Carbon Monoxide Information Center The Invisible Killer Carbon ...

  17. About the ADEAR Center

    Science.gov (United States)

    ... and news updates How to Contact the ADEAR Center Call toll-free at: 1-800-438-4380 (8: ... To give you the best possible service, ADEAR Center staff abide by the following customer service standards: We will answer your telephone calls promptly between 8:30 a.m. and 5: ...

  18. From Periphery To Center

    DEFF Research Database (Denmark)

    Carré, David

    2014-01-01

    notions of Center/Periphery. As Hermans (2001) proposed, center and periphery are not fixed ‘I-positions’ of the self; in this vein, these notions are explored as relevant theoretical tools for addressing the developmental trajectories involved in the construction of scientific identities. In sum, the...

  19. Simple Machine Science Centers

    Science.gov (United States)

    Chessin, Debby

    2007-01-01

    Science centers can engage students; accommodate different learning styles and individual interests; help students become independent and confident learners; and encourage social skills among students. In this article, the author worked with third-grade students as they completed activities at learning centers during a week-long unit on simple…

  20. Technology Information Center

    International Nuclear Information System (INIS)

    A Transportation Technology Center (TTC) has been established at Sandia to address the transportation of nuclear waste and spent fuel. The Technology Information Center (TIC) acts as TTC's clearing house for nuclear material transportation information. TIC's activities are divided into three activities: public information, policy information, and technical information. Some of the uses of TIC's activities are briefly outlined

  1. Call Center Capacity Planning

    DEFF Research Database (Denmark)

    Nielsen, Thomas Bang

    The main topics of the thesis are theoretical and applied queueing theory within a call center setting. Call centers have in recent years become the main means of communication between customers and companies, and between citizens and public institutions. The extensively computerized infrastructure...

  2. Relative Lyapunov Center Bifurcations

    DEFF Research Database (Denmark)

    Wulff, Claudia; Schilder, Frank

    2014-01-01

    Relative equilibria (REs) and relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur, for example, in celestial mechanics, molecular dynamics, and rigid body motion. REs are equilibria, and RPOs are periodic orbits of the symmetry reduced system. Relative Lyapunov...... center bifurcations are bifurcations of RPOs from REs corresponding to Lyapunov center bifurcations of the symmetry reduced dynamics. In this paper we first prove a relative Lyapunov center theorem by combining recent results on the persistence of RPOs in Hamiltonian systems with a symmetric Lyapunov...... center theorem of Montaldi, Roberts, and Stewart. We then develop numerical methods for the detection of relative Lyapunov center bifurcations along branches of RPOs and for their computation. We apply our methods to Lagrangian REs of the N-body problem....

  3. Caveolin-1, E-cadherin and β-catenin in Gastric Carcinoma, Precancerous Tissues and Chronic Non-atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Guo-yang Sun; Jun-xia Wu; Jian-sheng Wu; Yu-ting Pan; Rong Jin

    2012-01-01

    Objective:To investigate the expressions of caveolin-1,E-cadherin and β-catenin in gastric carcinoma,precancerous gastric and chronic non-atrophic gastritis tissues,and evaluate the correlation of these expressions with the development of gastric cancer.Methods:The expressions of caveolin-1,E-cadherin and β-catenin were detected by biotin-streptavidinperoxidase (SP) immunohistochemistry on 58 gastric cancer tissues,40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues.The correlation between the expressions of caveolin-1,E-cadherin and β-catenin,and the clinicopathologic parameters of gastric cancer was analyzed retrospectively.Results:The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01).An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01).Moreover,low expressions of caveolin-1,E-cadherin and β-catenin correlated with tumor size,depth of invasion,lymph node metastasis and TNM stage (P<0.05).The positive rates of caveolin-1 and E-cadherin expressions decreased (P<0.01),while an abnormal rate of β-catenin expression increased inversely,with the degree of atypical hyperplasia (P<0.01).Caveolin-1 expression correlated positively with E-cadherin (r=0.41,P<0.05).Caveolin-1 (r=-0.36,P<0.05) and E-cadherin (r=-0.45,P<0.05) expressions negatively correlated with abnormal β-catenin expression.Conclusion:These results suggested that dysregulated expressions of caveolin-1,E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.

  4. Energy efficient data centers

    Energy Technology Data Exchange (ETDEWEB)

    Tschudi, William; Xu, Tengfang; Sartor, Dale; Koomey, Jon; Nordman, Bruce; Sezgen, Osman

    2004-03-30

    Data Center facilities, prevalent in many industries and institutions are essential to California's economy. Energy intensive data centers are crucial to California's industries, and many other institutions (such as universities) in the state, and they play an important role in the constantly evolving communications industry. To better understand the impact of the energy requirements and energy efficiency improvement potential in these facilities, the California Energy Commission's PIER Industrial Program initiated this project with two primary focus areas: First, to characterize current data center electricity use; and secondly, to develop a research ''roadmap'' defining and prioritizing possible future public interest research and deployment efforts that would improve energy efficiency. Although there are many opinions concerning the energy intensity of data centers and the aggregate effect on California's electrical power systems, there is very little publicly available information. Through this project, actual energy consumption at its end use was measured in a number of data centers. This benchmark data was documented in case study reports, along with site-specific energy efficiency recommendations. Additionally, other data center energy benchmarks were obtained through synergistic projects, prior PG&E studies, and industry contacts. In total, energy benchmarks for sixteen data centers were obtained. For this project, a broad definition of ''data center'' was adopted which included internet hosting, corporate, institutional, governmental, educational and other miscellaneous data centers. Typically these facilities require specialized infrastructure to provide high quality power and cooling for IT equipment. All of these data center types were considered in the development of an estimate of the total power consumption in California. Finally, a research ''roadmap'' was developed

  5. User-centered design

    International Nuclear Information System (INIS)

    The simplification philosophy, as an example, that both of EPRI-URD and EUR emphasize is treated mostly for the cost reduction of the nuclear power plants, but not for the simplification of the structure of user's tasks, which is one of the principles of user-centered design. A user-centered design is a philosophy based on the needs and interests of the user, with an emphasis on making products usable and understandable. However, the nuclear power plants offered these days by which the predominant reactor vendors are hardly user-centered but still designer-centered or technology-centered in viewpoint of fulfilling user requirements. The main goal of user-centered design is that user requirements are elicited correctly, reflected properly into the system requirements, and verified thoroughly by the tests. Starting from the user requirements throughout to the final test, each requirement should be traceable. That's why requirement traceability is a key to the user-centered design, and main theme of a requirement management program, which is suggested to be added into EPRI-URD and EUR in the section of Design Process. (author)

  6. Fusion engineering design center

    International Nuclear Information System (INIS)

    In the spring of 1985, the Department of Energy (DOE) directed the Design Center to take a lead responsibility in assessing the engineering feasibility of a very compact tokamak experiment with copper coils. Following this assessment, the Design Center studied the Ignitor concept at the request of DOE and arrived at a design configuration. Many features of this configuration have been incorporated into the national baseline conceptual design for a Compact Ignition Tokamak (CIT). The Design Center continued to participate in the mirror program by contributing to the Minimars design effort, a two-year program to develop and describe an attractive tandem mirror reactor concept. The Design Center's principal role is in configuration definition of the candidate concepts. The Design Center continues to lead the engineering activities for the International Tokamak Reactor program. Advanced commercial tokamaks were studied by the Design Center as part of the Tokamak Power Systems Studies project coordinated by the DOE Office of Fusion Energy. The Design Center also provided design integration of the US effort. A cost accounting system that is applicable to all magnetic fusion reactor design studies was developed and applied to different confinement concepts and types of projects. The system provides the structure for development of a fusion cost database and validated cost estimating procedures

  7. Lens auto-centering

    Science.gov (United States)

    Lamontagne, Frédéric; Desnoyers, Nichola; Doucet, Michel; Côté, Patrice; Gauvin, Jonny; Anctil, Geneviève; Tremblay, Mathieu

    2015-09-01

    In a typical optical system, optical elements usually need to be precisely positioned and aligned to perform the correct optical function. This positioning and alignment involves securing the optical element in a holder or mount. Proper centering of an optical element with respect to the holder is a delicate operation that generally requires tight manufacturing tolerances or active alignment, resulting in costly optical assemblies. To optimize optical performance and minimize manufacturing cost, there is a need for a lens mounting method that could relax manufacturing tolerance, reduce assembly time and provide high centering accuracy. This paper presents a patent pending lens mounting method developed at INO that can be compared to the drop-in technique for its simplicity while providing the level of accuracy close to that achievable with techniques using a centering machine (usually innovative auto-centering method is based on the use of geometrical relationship between the lens diameter, the lens radius of curvature and the thread angle of the retaining ring. The autocentering principle and centering test results performed on real optical assemblies are presented. In addition to the low assembly time, high centering accuracy, and environmental robustness, the INO auto-centering method has the advantage of relaxing lens and barrel bore diameter tolerances as well as lens wedge tolerances. The use of this novel lens mounting method significantly reduces manufacturing and assembly costs for high performance optical systems. Large volume productions would especially benefit from this advancement in precision lens mounting, potentially providing a drastic cost reduction.

  8. Status of center dominance in various center gauges

    OpenAIRE

    Faber, M; Greensite, J.; Olejnik, S.

    2002-01-01

    We review arguments for center dominance in center gauges where vortex locations are correctly identified. We introduce an appealing interpretation of the maximal center gauge, discuss problems with Gribov copies, and a cure to the problems through the direct Laplacian center gauge. We study correlations between direct and indirect Laplacian center gauges.

  9. Center for Contaminated Sediments

    Data.gov (United States)

    Federal Laboratory Consortium — The U.S. Army Corps of Engineers Center for Contaminated Sediments serves as a clearinghouse for technology and expertise concerned with contaminated sediments. The...

  10. HUD Homeownership Centers

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    Department of Housing and Urban Development — HUD Homeownership Centers (HOCs) insure single family Federal Housing Administration (FHA) mortgages and oversee the selling of HUD homes. FHA has four...

  11. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Chairman Commissioners Contact Information Agency Reports Legislative Affairs Job Opportunities Inspector General Safety Guides Safety Education Centers OnSafety Blog Neighborhood Safety Network Community Outreach ...

  12. National Pesticide Information Center

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    National Pesticide Information Center npic@ace.orst.edu 1.800.858.7378 Index A B C D E F ... Your Pest Control Your Pest Integrated Pest Management Pesticide Ingredients Active Ingredients Other/Inert Ingredients Pesticide Products ...

  13. ADVANCED DATA CENTER ECONOMY

    OpenAIRE

    Sukhov, R.; Amzarakov, M.; Isaev, E.

    2013-01-01

    The article addresses basic Data Centers (DC) drivers of price and engineering, which specify rules and price evaluation for creation and further operation. DC energy efficiency concept, its influence on DC initial price, operation costs and Total Cost of Ownership.

  14. Center Innovation Fund Program

    Data.gov (United States)

    National Aeronautics and Space Administration — To stimulate and encourage creativity and innovation within the NASA Centers. The activities are envisioned to fall within the scope of NASA Space Technology or...

  15. FEMA Disaster Recovery Centers

    Data.gov (United States)

    Department of Homeland Security — This is a search site for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  16. National Automotive Center - NAC

    Data.gov (United States)

    Federal Laboratory Consortium — Encouraged by the advantages of collaboration, the U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) worked with the Secretary of the...

  17. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Safety Network Community Outreach Resource Center CO Poster Contest Toy Recall Statistics Pool Safely Home / Safety Education / ... VIDEO CPSC announces winners of carbon monoxide poster contest View the blog SAFETY GUIDE Clues You Can ...

  18. USU Patient Simulation Center

    Data.gov (United States)

    Federal Laboratory Consortium — he National Capital Area (NCA) Medical Simulation Center is a state-of-the-art training facility located near the main USU campus. It uses simulated patients (i.e.,...

  19. Accredited Birth Centers

    Science.gov (United States)

    ... 717-933-9743 Accredited since January 2016 100 Bright Eyes Midwifery and Wild Rivers Women's Health Accredited ... Birthing Center-Cedar Park Accredited 1130 Cottonwood Creek Trail Building D Suite 2 Cedar Park, TX 78613 ...

  20. Reliability Centered Maintenance - Methodologies

    Science.gov (United States)

    Kammerer, Catherine C.

    2009-01-01

    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  1. Advanced Missile Signature Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Missile Signature Center (AMSC) is a national facility supporting the Missile Defense Agency (MDA) and other DoD programs and customers with analysis,...

  2. CNPC International Research Center

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ CNPC International Research Center (CNPCIRC), jointly managed by CNODC and RIPED of China National Petroleum Corporation (CNPC), was established in 1999 for providing technical research support to all the overseas oil and gas projects of CNPC.

  3. Health Center Controlled Network

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Health Center Controlled Network (HCCN) tool is a locator tool designed to make data and information concerning HCCN resources more easily available to our...

  4. Poison Control Centers

    Science.gov (United States)

    ... King St., Suite 510 Alexandria, VA 22314 Online http://www.aapcc.org/ Email not for emergency use. ... Poison Center" in the memo line. Donate online: http://bit.ly/1HDxdHb Tucson, AZ 85721 Online http:// ...

  5. Hazardous Waste Research Center

    Data.gov (United States)

    Federal Laboratory Consortium — A full-service research and evaluation center equipped with safety equipment, a high-bay pilot studies area, and a large-scale pilot studies facility The U.S. Army...

  6. World Trade Center

    Index Scriptorium Estoniae

    2006-01-01

    Esilinastus katastroofifilm "World Trade Center" : stsenarist Andrea Berloff : režissöör Oliver Stone : kunstnik Jan Roelfs : osades Nicholas Cage, Michael Pena, Stephen Dorff jpt : Ameerika Ühendriigid 2006. Ka filmi prototüüpidest

  7. Cooperative Tagging Center (CTC)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Cooperative Tagging Center (CTC) began as the Cooperative Game Fish Tagging Program (GTP) at Woods Hole Oceanographic Institute (WHOI) in 1954. The GTP was...

  8. NuSTAR and XMM-Newton observations of 1E1743.1-2843: indications of a neutron star LMXB nature of the compact object

    CERN Document Server

    Lotti, Simone; Mori, Kaya; Baganoff, Frederick K; Boggs, Steven E; Christensen, Finn E; Craig, William W; Hailey, Charles J; Harrison, Fiona A; Hong, Jaesub; Krivonos, Roman A; Rahoui, Farid; Stern, Daniel; Tomsick, John A; Zhang, Shuo; Zhang, William W

    2016-01-01

    We report on the results of NuSTAR and XMM-Newton observations of the persistent X-ray source \\object{1E1743.1-2843}, located in the Galactic Center region. The source was observed between September and October 2012 by NuSTAR and XMM-Newton, providing almost simultaneous observations in the hard and soft X-ray bands. The high X-ray luminosity points to the presence of an accreting compact object. We analyze the possibilities of this accreting compact object being either a neutron star (NS) or a black hole, and conclude that the joint XMM-Newton and NuSTAR spectrum from 0.3 to 40 $\\mathrm{keV}$ fits to a black body spectrum with $kT\\sim1.8~\\mathrm{keV}$ emitted from a hot spot or an equatorial strip on a neutron star surface. This spectrum is thermally Comptonized by electrons with $kT_{e}\\sim4.6~\\mathrm{keV}$. Accepting this neutron star hypothesis, we probe the Low Mass (LMXB) or High Mass (HMXB) X-ray Binary nature of the source. While the lack of Type-I bursts can be explained in the LMXB scenario, the abs...

  9. The BPV-1 E2 DNA-contact helix cysteine is required for transcriptional activation but not replication in mammalian cells.

    Science.gov (United States)

    Grossel, M J; Barsoum, J; Prakash, S S; Androphy, E J

    1996-03-01

    The papillomavirus E2 protein contains an amino-terminal region thought necessary and sufficient to support transcriptional activation and a carboxy-terminal region shown to direct sequence-specific DNA binding and dimerization. A cysteine residue in the center of the E2 DNA recognition helix is highly conserved among papillomavirus E2 proteins. Mutations of this cysteine in bovine papillomavirus type 1 E2 to serine and glycine resulted in proteins which failed to activate E2-dependent promoters in mammalian cells. These E2 mutants were DNA-binding competent, dimeric, and nuclear. When fused to the VP16 transactivation domain, C-terminal regions of E2 containing the mutations at 340 supported transcriptional activation, indicating that the heterologous trans-activation domain did not require cysteine in the DNA-binding helix as did the full-length E2 transactivating protein. Although cysteine-340 was required for transcriptional activation it was not required for DNA replication in vivo. Together, these results suggest that the E2 DNA-binding domain may directly contribute to functions of transcriptional activation previously thought limited to the N-terminal domain. PMID:8599215

  10. The Galactic Center

    OpenAIRE

    R. Genzel; Karas, V.

    2007-01-01

    In the past decade high resolution measurements in the infrared employing adaptive optics imaging on 10m telescopes have allowed determining the three dimensional orbits stars within ten light hours of the compact radio source at the center of the Milky Way. These observations show the presence of a three million solar mass black hole in Sagittarius A* beyond any reasonable doubt. The Galactic Center thus constitutes the best astrophysical evidence for the existence of black holes which have ...

  11. Oil Reserve Center Established

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Like other countries,China has started to grow its strategic oil reserve in case oil supplies are cut On December 18,2007,the National Development and Reform Commission(NDRC),China’s top economic planner,announced that the national oil reserve center has been officially launched.The supervisory system over the oil reserves has three levels: the energy department of the NDRC,the oil reserve center,and the reserve bases.

  12. Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells

    DEFF Research Database (Denmark)

    Nygaard, Sanne Bjørn; Larsen, Agnete; Knuhtsen, Astrid;

    2014-01-01

    )-ethylenediamine. The changes in intracellular insulin content following exposure to various concentrations of zinc were reflected by changes in the expression patterns of MT-1A, ZnT-8, ZnT-5, and ZnT-3. Furthermore, high zinc concentrations induced cell necrosis while zinc chelation induced apoptosis. Finally, cell......BACKGROUND: Zinc is essential for the activities of pancreatic β-cells, especially insulin storage and secretion. Insulin secretion leads to co-release of zinc which contributes to the paracrine communication in the pancreatic islets. Zinc-transporting proteins (zinc-regulated transporter, iron......-regulated transporter-like proteins [ZIPs] and zinc transporters [ZnTs]) and metal-buffering proteins (metallothioneins, MTs) tightly regulate intracellular zinc homeostasis. The present study investigated how modulation of cellular zinc availability affects β-cell function using INS-1E cells. RESULTS: Using INS-1E...

  13. Gamma-Rays and E0 and M1+E0 Transitions in $^{152}Tb \\to ^{152}$Gd Decay

    CERN Document Server

    Adam, J; Honusek, M; Kalinnikov, V G; Mrazek, J; Pronskikh, V S; Caloun, P; Lebedev, N A; Stegailov, V I; Tsoupko-Sitnikov, V M

    2001-01-01

    The decay of ^{152}Tb has been investigated by means of measurements of single gamma-spectra. The 704 transitions were observed, of which 347 were identified to the decay of ^{152}Tb for the first time. Using the more precise and full data about intensities of gamma-transitions and previously reported conversion electron intensities the E0 or M1+E0 multipolarities were established for several transitions.

  14. The Racine-1e critical experiments for control-rod method and data validation experimental and calculation results

    International Nuclear Information System (INIS)

    This paper summarizes the results of control rod experiments, performed in the heterogeneous double ring core RACINE-1E, investigated as part of the RACINE programme at the French zero-power-facility MASURCA. Measurements were made using both natural and highly enriched boron carbide adsorbers and comprised subcritical and critical experiments. The analysis was carried out using methods similar to those used by CEA for the prediction of rod worths in LMFBR power reactors

  15. Characterization of the Functional Activities of the Bovine Papillomavirus Type 1 E2 Protein Single-Chain Heterodimers▿

    OpenAIRE

    Kurg, Reet; Tekkel, Helena; Abroi, Aare; Ustav, Mart

    2006-01-01

    Papillomaviruses are small DNA viruses which establish persistent infection in the epithelial tissue of various animal species. Three papillomavirus proteins encoded by the bovine papillomavirus type 1 E2 open reading frame have a common C-terminal DNA binding and dimerization domain and function as dimeric proteins in the regulation of viral gene expression, genome replication, and maintenance. The full-length E2 protein, expressed usually at the lowest level of the three, is an activator, w...

  16. Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.

    OpenAIRE

    Thierry, F; Dostatni, N; Arnos, F; Yaniv, M

    1990-01-01

    The viral transcriptional factors encoded by the E2 open reading frame bind to the specific DNA sequence elements ACCGNNNNCGGT, allowing activation or repression of transcription. We have analyzed bovine papillomavirus type 1 E2 transactivation using recombinant genes containing E2-binding sites inserted at either 3' or 5' positions relative to the heterologous transcriptional initiation site of the herpes simplex virus thymidine kinase gene. In these hybrid plasmids, strong transactivation r...

  17. HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.

    OpenAIRE

    HiroyukiSakai; NaokoKajitani; AyanoSatsuka; SatoshiYoshida

    2013-01-01

    Papillomavirus is the etiological agent for warts and several squamous carcinomas. Skin cancer induced by cottontail rabbit papillomavirus (CRPV) was the first animal model for virus-induced carcinogenesis. The target organ of the virus infection is stratified epithelium and virus replication is tightly regulated by the differentiation program of the host cell. E1^E4 protein is a viral gene product, and although it is considered to be involved in the control of virus replication, little is kn...

  18. AKT1 E17K mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection

    OpenAIRE

    Rudolph, Marion; Anzeneder, Tobias; Schulz, Anke; Beckmann, Georg; Byrne, Annette T.; Jeffers, Michael; Pena, Carol; Politz, Oliver; Köchert, Karl; Vonk, Richardus; Reischl, Joachim

    2016-01-01

    Background: The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown.Methods: We analyzed more than 600 breast cancer tumor samples and circulating tumor DNA for AKT1 E17K and alterations in other cancer-associated genes using Beads, Emulsions, Amplification, and Magnetics digital polymerase chain reaction technology and targeted exome sequencing.Resul...

  19. AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection.

    OpenAIRE

    Rudolph, Marion; Anzeneder, Tobias; Schulz, Anke; Beckmann, Georg; Byrne, Annette T.; Jeffers, Michael; Pena, Carol; Politz, Oliver; Köchert, Karl; Vonk, Richardus; Reischl, Joachim

    2016-01-01

    BACKGROUND: The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown. METHODS: We analyzed more than 600 breast cancer tumor samples and circulating tumor DNA for AKT1 (E17K) and alterations in other cancer-associated genes using Beads, Emulsions, Amplification, and Magnetics digital polymerase chain reaction technology and targeted exome sequencing...

  20. Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer.

    Science.gov (United States)

    Soriano, Jorge L; Batista, Noyde; Santiesteban, Eduardo; Lima, Mayté; González, Joaquín; García, Robin; Zarza, Yohanka; López, María V; Rodríguez, Myriam; Loys, Jorge L; Montejo, Narciso; Aguirre, Frank; Macías, Amparo; Vázquez, Ana M

    2011-01-01

    The use of low doses of cytotoxic agents continuously for prolonged periods is an alternative for the treatment of patients with metastatic breast cancer who have developed resistance to conventional chemotherapy. The combination of metronomic chemotherapy with therapeutic vaccines might increase the efficacy of the treatment. Twenty one patients with metastatic breast cancer in progression and a Karnosky index ≥60%, were treated with metronomic chemotherapy (50 mg of cyclophospamide orally daily and 2.5 mg of methotrexate orally bi-daily), in combination with five bi-weekly subcutaneous injections of 1 mg of aluminum hydroxide-precipitated 1E10 anti-idiotype MAb (1E10-Alum), followed by reimmunizations every 28 days. Five patients achieved objective response, eight showed stable disease and eight had disease progression. Median time to progression was 9,8 months, while median overall survival time was 12,93 months. The median duration of the response (CR+PR+SD) was 18,43 months (12,20-24,10 months), being higher than 12 months in 76,9% of the patients. Overall toxicity was generally mild. Metronomic chemotherapy combined with 1E10-Alum vaccine immunotherapy might be a useful therapeutic option for the treatment of metastatic breast cancer due to its potential impact on survival and patient quality of live, low toxicity and advantages of the administration. PMID:22295231

  1. A glitch and an anti-glitch in the anomalous X-ray pulsar 1E 1841-045

    CERN Document Server

    Mus, Sinem Sasmaz; Gogus, Ersin

    2014-01-01

    We investigated the long-term spin properties of the anomalous X-ray pulsar (AXP) 1E 1841-045 by performing a temporal analysis of archival RXTE observations spanning about 5.2 yr from 2006 September to 2011 December. We identified two peculiar timing anomalies within ~1 yr of each other: a glitch with Delta(nu)/nu ~ 4.8 x 10^{-6} near MJD 54303; and an anti-glitch with Delta(nu)/nu ~ -5.8 x 10^{-7} near MJD 54656. The glitch that we identified, which is the fourth glitch seen in this source in the 13 yr of RXTE monitoring, is similar to the last two detected glitches. The anti-glitch from 1E 1841-045, however, is the first to be identified. The amplitude of the anti-glitch was comparable with that recently observed in AXP 1E 2259+586. We found no significant variations in the pulsed X-ray output of the source during either the glitch or the anti-glitch. We discuss our results in relation to the standard pulsar glitch mechanisms for the glitch, and to plausible magnetospheric scenarios for the anti-glitch.

  2. Suppression of the Nuclear Factor Eny2 Increases Insulin Secretion in Poorly Functioning INS-1E Insulinoma Cells

    Directory of Open Access Journals (Sweden)

    P. Dames

    2012-01-01

    Full Text Available Eny2, the mammalian ortholog of yeast Sus1 and drosophila E(y2, is a nuclear factor that participates in several steps of gene transcription and in mRNA export. We had previously found that Eny2 expression changes in mouse pancreatic islets during the metabolic adaptation to pregnancy. We therefore hypothesized that the protein contributes to the regulation of islet endocrine cell function and tested this hypothesis in rat INS-1E insulinoma cells. Overexpression of Eny2 had no effect but siRNA-mediated knockdown of Eny2 resulted in markedly increased glucose and exendin-4-induced insulin secretion from otherwise poorly glucose-responsive INS-1E cells. Insulin content, cellular viability, and the expression levels of several key components of glucose sensing remained unchanged; however glucose-dependent cellular metabolism was higher after Eny2 knockdown. Suppression of Eny2 enhanced the intracellular incretin signal downstream of cAMP. The use of specific cAMP analogues and pathway inhibitors primarily implicated the PKA and to a lesser extent the EPAC pathway. In summary, we identified a potential link between the nuclear protein Eny2 and insulin secretion. Suppression of Eny2 resulted in increased glucose and incretin-induced insulin release from a poorly glucose-responsive INS-1E subline. Whether these findings extend to other experimental conditions or to in vivo physiology needs to be determined in further studies.

  3. Observations of the magnetars 4U 0142+61 and 1E 2259+586 with the MAGIC telescopes

    CERN Document Server

    Aleksić, J; Antoranz, P; Asensio, M; de Almeida, U Barres; Barrio, J A; Bednarek, W; Berger, K; Bernardini, E; Biland, A; Blanch, O; Bock, R K; Boller, A; Bonnefoy, S; Bonnoli, G; Tridon, D Borla; Bretz, T; Carmona, E; Carosi, A; Fidalgo, D Carreto; Colin, P; Colombo, E; Contreras, J L; Cortina, J; Cossio, L; Covino, S; Da Vela, P; Dazzi, F; De Angelis, A; De Caneva, G; De Lotto, B; Mendez, C Delgado; Doert, M; Domínguez, A; Prester, D Dominis; Dorner, D; Doro, M; Eisenacher, D; Elsaesser, D; Ferenc, D; Fonseca, M V; Font, L; Fruck, C; López, R J García; Garczarczyk, M; Terrats, D Garrido; Gaug, M; Giavitto, G; Godinović, N; Muñoz, A González; Gozzini, S R; Hadamek, A; Hadasch, D; Herrero, A; Hose, J; Hrupec, D; Jankowski, F; Kadenius, V; Klepser, S; Knoetig, M L; Krähenbühl, T; Krause, J; Kushida, J; La Barbera, A; Lelas, D; Leonardo, E; Lewandowska, N; Lindfors, E; Lombardi, S; López, M; López-Coto, R; López-Oramas, A; Lorenz, E; Lozano, I; Makariev, M; Mallot, K; Maneva, G; Mankuzhiyil, N; Mannheim, K; Maraschi, L; Marcote, B; Mariotti, M; Martínez, M; Masbou, J; Mazin, D; Meucci, M; Miranda, J M; Mirzoyan, R; Moldón, J; Moralejo, A; Munar-Adrover, P; Nakajima, D; Niedzwiecki, A; Nieto, D; Nilsson, K; Nowak, N; Orito, R; Paiano, S; Palatiello, M; Paneque, D; Paoletti, R; Paredes, J M; Partini, S; Persic, M; Pilia, M; Prada, F; Moroni, P G Prada; Prandini, E; Puljak, I; Reichardt, I; Reinthal, R; Rhode, W; Ribó, M; Rico, J; Rügamer, S; Saggion, A; Saito, K; Saito, T Y; Salvati, M; Satalecka, K; Scalzotto, V; Scapin, V; Schultz, C; Schweizer, T; Shore, S N; Sillanpää, A; Sitarek, J; Snidaric, I; Sobczynska, D; Spanier, F; Spiro, S; Stamatescu, V; Stamerra, A; Steinke, B; Storz, J; Sun, S; Surić, T; Takalo, L; Takami, H; Tavecchio, F; Temnikov, P; Terzić, T; Tescaro, D; Teshima, M; Tibolla, O; Torres, D F; Toyama, T; Treves, A; Uellenbeck, M; Vogler, P; Wagner, R M; Weitzel, Q; Zandanel, F; Zanin, R; Rea, N

    2012-01-01

    Magnetars are an extreme, highly magnetized class of isolated neutron stars whose large X-ray luminosity is believed to be driven by their high magnetic field. In this work we study for the first time the possible very high energy gamma-ray emission above 100 GeV from magnetars, observing the sources 4U 0142+61 and 1E 2259+586. We observed the two sources with atmospheric Cherenkov telescopes in the very high energy range (E > 100 GeV). 4U 0142+61 was observed with the MAGIC I telescope in 2008 for ~25 h and 1E 2259+586 was observed with the MAGIC stereoscopic system in 2010 for ~14 h. The data were analyzed with the standard MAGIC analysis software. Neither magnetar was detected. Upper limits to the differential and integral flux above 200 GeV were computed using the Rolke algorithm. We obtain integral upper limits to the flux of 1.52*10^-12cm^-2 s^-1 and 2.7*10^-12cm^-2 s^-1 with a confidence level of 95% for 4U 0142+61 and 1E 2259+586, respectively. The resulting differential upper limits are presented tog...

  4. THE HUMORAL AND CELLULAR IMMUNE RESPONSES INDUCED BY HPV18L1-E6/E7 DNA VACCINES IN MICE

    Institute of Scientific and Technical Information of China (English)

    Yang Jin; Li Xu; Li Ang; Wang Yili; Si Lüsheng

    2006-01-01

    Objective To construct eukaryotic expression vector of HPV18 L1- E6, E7 chimeric gene and examine the humoral and cellular immune responses induced by this DNA vaccines in mice. Methods The C-terminal of major capsid protein L1 gene and mutant zinc finger domains of early E6/7 oncogenes in HPV18 were integrated and inserted into eukaryotic expression vector pVAX1 to generate vaccines pVAX1-L1E6Mxx, E7Mxx. CHO cells were transiently transfected with the individual construct. Target protein expressions in the lysate of the transfected cells were measured by ELISA and immunocytochemistry. After BALB/c mice were vaccinated with various recombinant plasmids(pVAX1-L1-E6M3 or pVAX1-L1-E7M3) and immunie adjuvants (pLXHDmB7-2 or LTB) through different administration routes (intramuscular or intranasal) , the great cellular immune responses were produced as revealed by delayed-type hypersensitivity (DTH) and lymphocyte proliferation, and the expression of IL-4 and IFN- γ cells in CD4+ and CD8+subpopulations. Results The highly efficient expression of pVAX1-L1E6Mxx, E7Mxx vector in host eukaryotic cells were demonstrated both by ELISA and immunocytochemistry. The level of specific serum IgG against HPV in experiment groups mice was much higher than that of control group, and intranuscular immunization group had the highest antibody level. Intramuscular immunization groups were superior to intranasal immunization groups in DTH response, splenocyte proliferation and CD8+ IFN-γ + cells number, but CD4+ IL4+ cell number was higher in intranasal immunization groups. The immunization groups using pLXHDmB7-2 as adjuvant were superior to other groups in immunoresponse. Conclusion These DNA vaccines produce remarkable cellular and humoral immuneresponses in the mouse and may provide as prophylatic and therapeutic candidates for HPV induced cancer treatment.

  5. UCSF Center for HIV Information

    Science.gov (United States)

    ... Program For providers and patients VA National Viral Hepatitis Program For providers and patients TARGET Center Technical assistance tools for the Ryan White Community AETC National Resource Center Education and training for clinicians UCSF-Gladstone Center for ...

  6. Patient-centered Care.

    Science.gov (United States)

    Reynolds, April

    2009-01-01

    Patient-centered care focuses on the patient and the individual's particular health care needs. The goal of patient-centered health care is to empower patients to become active participants in their care. This requires that physicians, radiologic technologists and other health care providers develop good communication skills and address patient needs effectively. Patient-centered care also requires that the health care provider become a patient advocate and strive to provide care that not only is effective but also safe. For radiologic technologists, patient-centered care encompasses principles such as the as low as reasonably achievable (ALARA) concept and contrast media safety. Patient-centered care is associated with a higher rate of patient satisfaction, adherence to suggested lifestyle changes and prescribed treatment, better outcomes and more cost-effective care. This article is a Directed Reading. Your access to Directed Reading quizzes for continuing education credit is determined by your area of interest. For access to other quizzes, go to www.asrt.org/store. According to one theory, most patients judge the quality of their healthcare much like they rate an airplane flight. They assume that the airplane is technically viable and is being piloted by competent people. Criteria for judging a particular airline are personal and include aspects like comfort, friendly service and on-time schedules. Similarly, patients judge the standard of their healthcare on nontechnical aspects, such as a healthcare practitioner's communication and "soft skills." Most are unable to evaluate a practitioner's level of technical skill or training, so the qualities they can assess become of the utmost importance in satisfying patients and providing patient-centered care.(1). PMID:19901351

  7. Center for Botanical Interaction Studies

    Data.gov (United States)

    Federal Laboratory Consortium — Research Area: Dietary Supplements, Herbs, Antioxidants Program:Centers for Dietary Supplements Research: Botanicals Description:This center will look at safety and...

  8. Xichang Satellite Launch Center

    Institute of Scientific and Technical Information of China (English)

    LiuJie

    2004-01-01

    Xichang Satellite Launch Center(XSLC) is mainly for geosynchronous orbit launches. The main purpose of XSLC is to launch spacecraft, such as broadcasting,communications and meteorological satellites, into geo-stationary orbit.Most of the commercial satellite launches of Long March vehicles have been from Xichang Satellite Launch Center. With 20 years' development,XSLC can launch 5 kinds of launch vehicles and send satellites into geostationary orbit and polar orbit. In the future, moon exploration satellites will also be launched from XSLC.

  9. User Centered Design

    DEFF Research Database (Denmark)

    Egbert, Maria; Matthews, Ben

    The interdisciplinary approach of User Centered Design is presented here with a focus on innovation in the design and use of hearing technologies as well as on the potential of innovation in interaction. This approach is geared towards developing new products, systems, technologies and practices...... based on an understanding of why so few persons with hearing loss use the highly advanced hearing technologies. In integrating Conversation Analysis (“CA”), audiology and User Centered Design, three disciplines which are collaborating together for the first time, we are addressing the following...

  10. Spectroscopic investigation, photophysical parameters and DFT calculations of 4,4'-(1E,1'E)-2,2'-(pyrazine-2,5-diyl)bis(ethene-2,1-diyl)bis(N,N-dimethylaniline) (PENDA) in different solvents.

    Science.gov (United States)

    Asiri, Abdullah M; Alamry, Khalid A; Pannipara, Mehboobali; Al-Sehemi, Abdullah G; El-Daly, Samy A

    2015-10-01

    A comprehensive investigation on the photophysics of a π-conjugated potential push-pull chromophore system 4,4'-(1E,1'E)-2,2'-(Pyrazine-2,5-diyl)bis(ethene-2,1-diyl)bis(N,N-dimethylaniline) (PENDA) has been carried out spectroscopically. The optical absorption and emission properties of this molecule have been studied in different solvents. The molecule PENDA shows strong solvatochromic emission upon changing the solvent polarity from nonpolar to polar; indicating that emission state is of intramolecular charge transfer (ICT) character. The solvent effect on the spectral properties such as singlet absorption, molar absorptivity, oscillator strength, dipole moment and fluorescence quantum yield of PENDA have been studied in detail. Lippert-Mataga and Reichardt correlations were used to estimate the difference between the excited and ground state dipole moments (Δμ). Ground and electronic excited states geometric optimizations were performed using density functional theory (DFT) and time-dependent density functional theory (TDDFT), respectively, with the Gaussian 09 package. A solution of (8×10(-5) M) PENDA in THF, dioxane, CH3CN and CHCl3 gives laser emission when pumped by a nitrogen laser pulse (λex=337.1 nm) of 800 ps duration and 1.48 mJ pulse energy. PENDA dye displays fluorescence quenching by colloidal silver nanoparticles (Ag NPs) in ethanol. The fluorescence data reveal that dynamic quenching and energy transfer play a major role in the fluorescence quenching mechanism. PMID:25988818

  11. Observations of the magnetars 4U 0142+61 and 1E 2259+586 with the MAGIC telescopes

    Science.gov (United States)

    Aleksić, J.; Antonelli, L. A.; Antoranz, P.; Asensio, M.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Berger, K.; Bernardini, E.; Biland, A.; Blanch, O.; Bock, R. K.; Boller, A.; Bonnoli, G.; Borla Tridon, D.; Bretz, T.; Carmona, E.; Carosi, A.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Cossio, L.; Covino, S.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Caneva, G.; De Cea del Pozo, E.; De Lotto, B.; Delgado Mendez, C.; Diago Ortega, A.; Doert, M.; Dominis Prester, D.; Dorner, D.; Doro, M.; Eisenacher, D.; Elsaesser, D.; Ferenc, D.; Fonseca, M. V.; Font, L.; Fruck, C.; García López, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Giavitto, G.; Godinović, N.; González Muñoz, A.; Gozzini, S. R.; Hadamek, A.; Hadasch, D.; Häfner, D.; Herrero, A.; Hose, J.; Hrupec, D.; Huber, B.; Jankowski, F.; Jogler, T.; Kadenius, V.; Klepser, S.; Knoetig, M. L.; Krähenbühl, T.; Krause, J.; Kushida, J.; La Barbera, A.; Lelas, D.; Leonardo, E.; Lewandowska, N.; Lindfors, E.; Lombardi, S.; López, M.; López-Coto, R.; López-Oramas, A.; Lorenz, E.; Makariev, M.; Maneva, G.; Mankuzhiyil, N.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Mazin, D.; Meucci, M.; Miranda, J. M.; Mirzoyan, R.; Moldón, J.; Moralejo, A.; Munar-Adrover, P.; Niedzwiecki, A.; Nieto, D.; Nilsson, K.; Nowak, N.; Orito, R.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Partini, S.; Persic, M.; Pilia, M.; Pochon, J.; Prada, F.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Reichardt, I.; Reinthal, R.; Rhode, W.; Ribó, M.; Rico, J.; Rügamer, S.; Saggion, A.; Saito, K.; Saito, T. Y.; Salvati, M.; Satalecka, K.; Scalzotto, V.; Scapin, V.; Schultz, C.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Spanier, F.; Spiro, S.; Stamatescu, V.; Stamerra, A.; Steinke, B.; Storz, J.; Sun, S.; Surić, T.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Tibolla, O.; Torres, D. F.; Toyama, T.; Treves, A.; Uellenbeck, M.; Vogler, P.; Wagner, R. M.; Weitzel, Q.; Zabalza, V.; Zandanel, F.; Zanin, R.; Rea, N.; Backes, M.

    2013-01-01

    Context. Magnetars are an extreme, highly magnetized class of isolated neutron stars whose large X-ray luminosity is believed to be driven by their high magnetic field. Aims: We study for the first time the possible very high energy γ-ray emission above 100 GeV from magnetars, observing the sources 4U 0142+61 and 1E 2259+586. Methods: We observed the two sources with atmospheric Cherenkov telescopes in the very high energy range (E > 100 GeV). 4U 0142+61 was observed with the MAGIC I telescope in 2008 for about 25 h and 1E 2259+586 was observed with the MAGIC stereoscopic system in 2010 for about 14 h. The data were analyzed with the standard MAGIC analysis software. Results: Neither magnetar was detected. Upper limits to the differential and integral flux above 200 GeV were computed using the Rolke algorithm. We obtain integral upper limits to the flux of 1.52 × 10-12 cm-2 s-1 and 2.7 × 10-12 cm-2 s-1 with a confidence level of 95% for 4U 0142+61 and 1E 2259+586, respectively. The resulting differential upper limits are presented together with X-ray data and upper limits in the GeV energy range. FITS files are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr(130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/549/A23

  12. Crystal Structure of UBA2[superscript ufd]-Ubc9: Insights into E1-E2 Interactions in Sumo Pathways

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jing; Taherbhoy, Asad M.; Hunt, Harold W.; Seyedin, Steven N.; Miller, David W.; Miller, Darcie J.; Huang, Danny T.; Schulman, Brenda A. (SJCH)

    2012-04-30

    Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to targets by E1-E2-E3 multienzyme cascades. The Sumo cascade, conserved among all eukaryotes, regulates numerous biological processes including protein localization, transcription, DNA replication, and mitosis. Sumo conjugation is initiated by the heterodimeric Aos1-Uba2 E1 enzyme (in humans called Sae1-Uba2), which activates Sumo's C-terminus, binds the dedicated E2 enzyme Ubc9, and promotes Sumo C-terminal transfer between the Uba2 and Ubc9 catalytic cysteines. To gain insights into details of E1-E2 interactions in the Sumo pathway, we determined crystal structures of the C-terminal ubiquitin fold domain (ufd) from yeast Uba2 (Uba2{sup ufd}), alone and in complex with Ubc9. The overall structures of both yeast Uba2{sup ufd} and Ubc9 superimpose well on their individual human counterparts, suggesting conservation of fundamental features of Sumo conjugation. Docking the Uba2{sup ufd}-Ubc9 and prior full-length human Uba2 structures allows generation of models for steps in Sumo transfer from Uba2 to Ubc9, and supports the notion that Uba2 undergoes remarkable conformational changes during the reaction. Comparisons to previous structures from the NEDD8 cascade demonstrate that UBL cascades generally utilize some parallel E1-E2 interaction surfaces. In addition, the structure of the Uba2{sup ufd}-Ubc9 complex reveals interactions unique to Sumo E1 and E2. Comparison with a previous Ubc9-E3 complex structure demonstrates overlap between Uba2 and E3 binding sites on Ubc9, indicating that loading with Sumo and E3-catalyzed transfer to substrates are strictly separate steps. The results suggest mechanisms establishing specificity and order in Sumo conjugation cascades.

  13. Economics of data center optics

    Science.gov (United States)

    Huff, Lisa

    2016-03-01

    Traffic to and from data centers is now reaching Zettabytes/year. Even the smallest of businesses now rely on data centers for revenue generation. And, the largest data centers today are orders of magnitude larger than the supercomputing centers of a few years ago. Until quite recently, for most data center managers, optical data centers were nice to dream about, but not really essential. Today, the all-optical data center - perhaps even an all-single mode fiber (SMF) data center is something that even managers of medium-sized data centers should be considering. Economical transceivers are the key to increased adoption of data center optics. An analysis of current and near future data center optics economics will be discussed in this paper.

  14. A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease

    OpenAIRE

    Vélez, Jorge I.; Dora Rivera; Claudio A. Mastronardi; Patel, Hardip R.; Carlos Tobón; Andrés Villegas; Yeping Cai; Simon Easteal; Francisco Lopera; Mauricio Arcos-Burgos

    2016-01-01

    We previously reported age of onset (AOO) modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and...

  15. Influence of organic ions on DNA damage induced by 1 eV to 60 keV electrons

    OpenAIRE

    Zheng, Yi; Sanche, Léon

    2010-01-01

    We report the results of a study on the influence of organic salts on the induction of single strand breaks (SSBs) and double strand breaks (DSBs) in DNA by electrons of 1 eV to 60 keV. Plasmid DNA films are prepared with two different concentrations of organic salts, by varying the amount of the TE buffer (Tris-HCl and EDTA) in the films with ratio of 1:1 and 6:1 Tris ions to DNA nucleotide. The films are bombarded with electrons of 1, 10, 100, and 60 000 eV under vacuum. The damage to the 3...

  16. The IΔKI = 1, E1 Transitions in Odd-A isotopes of Tb and Eu

    International Nuclear Information System (INIS)

    Life-time measurements have been performed for the 5/2- [532] intrinsic state in the Tb isotopes with A = 155, 157, 159, and 161. The rates of the ΔK = 1 E1 transitions in these isotopes, as well as in 153Eu and 155Eu, are discussed. With the Nilsson model as a starting point, the effects of pairing correlations and Coriolis coupling are calculated. It is found that these effects are not sufficient to account for the essential features of the experimental results. It is suggested that dipole contributions arising through octupole excitations are of importance

  17. 1E161348-5055 in the Supernova Remnant RCW 103: A Magnetar in a Young Low Mass Binary System?

    OpenAIRE

    Pizzolato, Fabio; Colpi, Monica; de Luca, Andrea; Mereghetti, Sandro; Tiengo, Andrea

    2008-01-01

    We suggest that the unique X-ray source 1E161348-5055 at the centre of the supernova remnant RCW 103 consists of a neutron star in close orbit with a low mass main sequence star. The time signature of 6.67 hr is interpreted as the neutron star's spin period. This requires the neutron star to be endowed with a high surface magnetic field of~10^15 G. Magnetic or/and material (propeller) torques are able to spin rapidly the young neutron star down to an asymptotic, equilibrium spin period in clo...

  18. Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation.

    OpenAIRE

    Benson, J D; Howley, P M

    1995-01-01

    Interaction between the E1 and E2 papillomavirus proteins appear to play an important role in viral DNA replication, although the exact domains of each protein involved in this interaction have not been identified. Using bovine papillomavirus type 1 (BPV-1) as a model for examining interactions between E1 and E2, we have used the two-hybrid and glutathione S-transferase (GST) fusion systems to map domains of BPV-1 E1 and E2 that interact in vivo and in vitro. In the two-hybrid system experime...

  19. Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB.

    OpenAIRE

    Rank, N M; Lambert, P F

    1995-01-01

    The bovine papillomavirus type 1 (BPV-1) E2 translational open reading frame encodes three proteins that regulate viral transcription and DNA replication: the E2 transcriptional activator (E2TA), the E2 transcriptional repressor (E2TR) and the E8/E2 transcriptional repressor (E8/E2TR). E2TA is a strong activator of papillomaviral promoters and is required for viral DNA replication. E2TR and E8/E2TR inhibit the activities of E2TA but also possess weak transactivational properties of their own....

  20. Optical identification of the supersoft X-ray source 1E 0035.4 in the Small Magellanic Cloud

    Science.gov (United States)

    Orio, M.; Della Valle, M.; Massone, G.; Ogelman, H.

    1994-01-01

    We report the identification of the optical counterpart of the Small Magellanic Cloud (SMC) super-soft X-ray source 1E0035.4- 7230 with a variable star of the magnitude B = 19.9-20.2 within the 40 arcsecs Einstein error box. The star shows strong UV excess, a hot, blue continuum and weak lines of high ionization. The lines are red-shifted by 3-4 A, indicating SMC membership. This object appears similar to CAL 83 and CAL 87 and is probably a binary system hosting an accreting, hydrogen burning white dwarf.

  1. An NTD germanium-based microcalorimeter with 3.1 eV energy resolution at 6 keV

    International Nuclear Information System (INIS)

    This paper reports recent advances in our microcalorimeter spectrometer that result in an energy resolution of 3.1 eV FWHM for 6 keV X-rays. We have developed a detailed model that indicates that further minor improvements will realize 2 eV FWHM at 6 keV and well under 2 eV at 1 keV. The results demonstrate the value of the microcalorimeter for many applications where a premium exists for very fine resolution in the 0.2-10 keV energy band

  2. IEEE Std 638-1992: IEEE standard for qualification of Class 1E transformers for nuclear power generating stations

    International Nuclear Information System (INIS)

    Procedures for demonstrating the adequacy of new Class 1E transformers, located in a mild environment of a nuclear power generating station, to perform their required safety functions under postulated service conditions, are presented. Single and three phase transformers rated 601 V to 15,000 V for the highest voltage winding and up to 2,500 kVA (self-cooled rating) are covered. Because of the conservative approach used in the development of this new standard for new transformers, the end point criteria cannot be used for in-service transformers

  3. Three Media Center Solutions.

    Science.gov (United States)

    Jadwin, Peggy

    1996-01-01

    An Illinois school district's multiyear, comprehensive plan requires the renovation of each school to accommodate state-of-the-art and future audiovisual and computer technology. A major part of each renovation is the school's media center. Five of the district's 13 schools have been renovated, with remaining schools set to be upgraded in phases…

  4. Starting a sleep center.

    Science.gov (United States)

    Epstein, Lawrence J; Valentine, Paul S

    2010-05-01

    The demand for sleep medicine services has grown tremendously during the last decade and will likely continue. To date, growth in demand has been met by growth in the number of new sleep centers. The need for more new centers will be dependent on market drivers that include increasing regulatory requirements, personnel shortages, integration of home sleep testing, changes in reimbursement, a shift in emphasis from diagnostics to treatment, and an increased consumer focus on sleep. The decision to open a new center should be based on understanding the market dynamics, completing a market analysis, and developing a business plan. The business plan should include an overview of the facility, a personnel and organizational structure, an evaluation of the business environment, a financial plan, a description of services provided, and a strategy for obtaining, managing, and extending a referral base. Implementation of the business plan and successful operation require ongoing planning and monitoring of operational parameters. The need for new sleep centers will likely continue, but the shifting market dynamics indicate a greater need for understanding the marketplace and careful planning. PMID:20442123

  5. vCenter troubleshooting

    CERN Document Server

    Mills, Chuck

    2015-01-01

    The book is designed for the competent vCenter administrator or anyone who is responsible for the vSphere environment. It can be used as a guide by vSphere architects and VMware consultants for a successful vSphere solution. You should have good knowledge and an understanding of core elements and applications of the vSphere environment.

  6. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Flickr SlideShare All Pages & Documents Recalls & News Releases Home Recalls CPSC Recall API Recall Lawsuits Recalls by ... CO Poster Contest Toy Recall Statistics Pool Safely Home / Safety Education / Safety Education Centers En Español Carbon ...

  7. DISABILITY STATISTICS CENTER

    Science.gov (United States)

    The purpose of the Disability Statistics Center is to produce and disseminate statistical information on disability and the status of people with disabilities in American society and to establish and monitor indicators of how conditions are changing over time to meet their health...

  8. Carolinas Energy Career Center

    Energy Technology Data Exchange (ETDEWEB)

    Classens, Anver; Hooper, Dick; Johnson, Bruce

    2013-03-31

    Central Piedmont Community College (CPCC), located in Charlotte, North Carolina, established the Carolinas Energy Career Center (Center) - a comprehensive training entity to meet the dynamic needs of the Charlotte region's energy workforce. The Center provides training for high-demand careers in both conventional energy (fossil) and renewable energy (nuclear and solar technologies/energy efficiency). CPCC completed four tasks that will position the Center as a leading resource for energy career training in the Southeast: • Development and Pilot of a New Advanced Welding Curriculum, • Program Enhancement of Non-Destructive Examination (NDE) Technology, • Student Support through implementation of a model targeted toward Energy and STEM Careers to support student learning, • Project Management and Reporting. As a result of DOE funding support, CPCC achieved the following outcomes: • Increased capacity to serve and train students in emerging energy industry careers; • Developed new courses and curricula to support emerging energy industry careers; • Established new training/laboratory resources; • Generated a pool of highly qualified, technically skilled workers to support the growing energy industry sector.

  9. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... an Unsafe Product Consumers Businesses Contact CPSC Website Design Feedback Consumers: Español Businesses: Español , 中文 , Tiếng Việt ... Chairman Commissioners Contact Information Agency Reports Legislative Affairs Job Opportunities Inspector General Safety Guides Safety Education Centers ...

  10. Precision Joining Center

    Energy Technology Data Exchange (ETDEWEB)

    Powell, J.W.; Westphal, D.A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10--12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of US industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  11. INTERMOUNTAIN INDUSTRIAL ASSESSMENT CENTER

    Energy Technology Data Exchange (ETDEWEB)

    MELINDA KRAHENBUHL

    2010-05-28

    The U. S. Department of Energy’s Intermountain Industrial Assessment Center (IIAC) at the University of Utah has been providing eligible small- and medium-sized manufacturers with no-cost plant assessments since 2001, offering cost-effective recommendations for improvements in the areas of energy efficiency, pollution prevention, and productivity improvement.

  12. The Rural Information Center.

    Science.gov (United States)

    John, Patricia La Caille

    1989-01-01

    Describes the events that led to the creation of the Rural Information Center (RIC), a joint venture between the Extension Service and the National Agricultural Library to provide information to government officials involved in rural development. The databases accessed by RIC are described, and plans for a gateway system and network of all…

  13. Vocabulary at the Center

    Science.gov (United States)

    Benjamin, Amy; Crow, John T.

    2009-01-01

    In "Vocabulary at the Center," Amy Benjamin and John T. Crow identify the most effective methods for extending the use of new words--in every grade level and across all subjects. This book shows teachers how to use context-driven exercises to incorporate new words into other areas of study. This book contains information about the authors, an…

  14. Classe 1E (category K1) measurement, control and power cables installed in PWR nuclear power plants in France

    International Nuclear Information System (INIS)

    The very special ambient conditions defined for a reactor building of a PWR nuclear power plant are such that very different types of cable from those used traditionally in the conventional parts of the power plant are required for class 1E and category K1 safety circuits. These new types of cables are intended for installation in the parts of nuclear power plants submitted to ionising radiation and to ambient temperatures which are often high. The reliability of this type of cable has been checked by means of an EDF qualification test, based partially on US standards and partly on original tests (long duration cyclical ageing tests, lasting 5000 hours) conducted by EDF on power cables which are representative of the behaviour of the service equipment. It is intended that these ageing methods should later be adopted and generalised for the qualification of future cables. Pursuant to this procedure, a qualification campaign has been carried out, during which the electrical and mechanical properties of the cables were measured and analysed after every stage. EDF has approved this type of cables for class 1E and category K1 safety circuits in 900 and 1300 MW PWR nuclear power plants

  15. A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer's Disease

    Science.gov (United States)

    Vélez, Jorge I.; Rivera, Dora; Mastronardi, Claudio A.; Patel, Hardip R.; Tobón, Carlos; Villegas, Andrés; Cai, Yeping; Easteal, Simon; Arcos-Burgos, Mauricio

    2016-01-01

    We previously reported age of onset (AOO) modifier genes in the world's largest pedigree segregating early-onset Alzheimer's disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and common functional variants located in those previously reported as AOO modifier loci were selected. Multiloci linear mixed-effects models were used to test the association between these variants and AOO. An exonic missense mutation in the G72 (DAOA) gene (rs2391191, P = 1.94 × 10−4, PFDR = 9.34 × 10−3) was found to modify AOO in PSEN1 E280A AD. Nominal associations of missense mutations in the CLUAP1 (rs9790, P = 7.63 × 10−3, PFDR = 0.1832) and EXOC2 (rs17136239, P = 0.0325, PFDR = 0.391) genes were also found. Previous studies have linked polymorphisms in the DAOA gene with the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD. Our findings strongly suggest that this new conspicuous functional AOO modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of AD. PMID:26949549

  16. Long-Term RXTE Monitoring of the Anomalous X-ray Pulsar 1E 1048.1-5937

    CERN Document Server

    Kaspi, V M; Chakraborty, D; Lackey, J R; Muno, M P; Kaspi, Victoria M.; Gavriil, Fotis P.; Chakrabarty, Deepto; Lackey, Jessica R.; Muno, Michael P.

    2000-01-01

    We report on long-term monitoring of the anomalous X-ray pulsar (AXP) 1E 1048.1-5937 using the Rossi X-ray Timing Explorer (RXTE). The timing behavior of this pulsar is different from that of other AXPs being monitored with RXTE. In particular, we show that the pulsar shows significant deviations from simple spin-down such that phase-coherent timing has not been possible over time spans longer than a few months. We find that the deviations from simple spin down are not consistent with single "glitch" type events, nor are they consistent with radiative precession. We show that in spite of the rotational irregularities, the pulsar exhibits neither pulse profile changes nor large pulsed flux variations. We discuss the implications of our results for AXP models. In the context of the magnetar model, we suggest that 1E 1048.1-5937 may be a transition object between the soft gamma-ray repeater and AXP populations, and the AXP most likely to one day undergo an outburst.

  17. American Overseas Research Centers Program

    Science.gov (United States)

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The American Overseas Research Centers Program provides grants to overseas research centers that are consortia of U.S. institutions of higher education to enable the centers to promote postgraduate research, exchanges, and area studies. Eligible applicants are those consortia of U.S. institutions of higher education centers that: (1) Receive more…

  18. Application Center 2000

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ 在NET Enterprise Servers中,Application Center 2000扮演着企业管理电子商务分布式应用程序的重要角色.ApplicationCenter 2000是可以建立在Windows 2000上的网站应用程序,能够有效率地管理、降低企业成本.它也是一个向外拓展的技术,且通过丛集服务(Cluster Service),可随需求增加其扩展性与可用性,以此降低随之而来的高成本和管理方式,以及提供配置(Deploy)丛集服务器的能力.

  19. Implicit Human Centered Tagging

    OpenAIRE

    Pantic, Maja; Vinciarelli, Alessandro

    2009-01-01

    Tagging is the annotation of multimedia data with userspecified keywords known as tags, with the aim of facilitating fast and accurate data retrieval based on these tags. In contrast to this process, also referred to as explicit tagging, implicit human-centered tagging (IHCT) refers to exploiting the information on user's nonverbal reactions (e.g., facial expressions like smiles or head gestures like shakes) to multimedia data, with which he or she interacts, to assign new or improve the exis...

  20. 4 Exhibition Centers

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China's convention and exhibition industry has grown rapidly in recent years, with some of the nation's key cities becoming hubs of internationally renowned expositions, spurred by the construction of new exhibition centers.In 2003, a total of 3,298 conventions and exhibitions were held in China, up from 3,075 in the previous year. The number is estimated to have hit 4,000 in 2004.

  1. Equestrian Competition Center

    OpenAIRE

    Canedy, Nicholas P

    2008-01-01

    This thesis explores the possibilities of using varied long span glue-laminated arches to create a dynamic structural enclosure over an expansive open surface. It investigates using arches that increase and decrease in height and span width, while varying in their lean. When combined with a fabric enclosure, they create a roof that constantly changes. The idea is to create a world class equestrian center that is visually exciting from both the interior and exterior, rather than...

  2. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT,J.

    2004-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security.

  3. Identification of ryanodine receptor isoforms in prostate DU-145, LNCaP, and PWR-1E cells.

    Science.gov (United States)

    Kobylewski, Sarah E; Henderson, Kimberly A; Eckhert, Curtis D

    2012-08-24

    The ryanodine receptor (RyR) is a large, intracellular calcium (Ca(2+)) channel that is associated with several accessory proteins and is an important component of a cell's ability to respond to changes in the environment. Three isoforms of the RyR exist and are well documented for skeletal and cardiac muscle and the brain, but the isoforms in non-excitable cells are poorly understood. The aggressiveness of breast cancers in women has been positively correlated with the expression of the RyR in breast tumor tissue, but it is unknown if this is limited to specific isoforms. Identification and characterization of RyRs in cancer models is important in understanding the role of the RyR channel complex in cancer and as a potential therapeutic target. The objective of this report was to identify the RyR isoforms expressed in widely used prostate cancer cell lines, DU-145 and LNCaP, and the non-tumorigenic prostate cell line, PWR-1E. Oligonucleotide primers specific for each isoform were used in semi-quantitative and real-time PCR to determine the identification and expression levels of the RyR isoforms. RyR1 was expressed in the highest amount in DU-145 tumor cells, expression was 0.48-fold in the non-tumor cell line PWR-1E compared to DU-145 cells, and no expression was observed in LNCaP tumor cells. DU-145 cells had the lowest expression of RyR2. The expression was 26- and 15-fold higher in LNCaP and PWR-1E cells, respectively. RyR3 expression was not observed in any of the cell lines. All cell types released Ca(2+) in response to caffeine showing they had functional RyRs. Total cellular RyR-associated Ca(2+) release is determined by both the number of activated RyRs and its accessory proteins which modulate the receptor. Our results suggest that the correlation between the expression of the RyR and tumor aggression is not related to specific RyR isoforms, but may be related to the activity and number of receptors. PMID:22846571

  4. Thermal, Electrical, and Optical Properties of Synthesized (1E, 2E-(4-bromophenyl(hydroxyiminoacetaldehyde Oxime Complexes

    Directory of Open Access Journals (Sweden)

    Emin Karapinar

    2013-01-01

    Full Text Available The (1E, 2E-(4-bromophenyl(hydroxyiminoacetaldehyde oxime complexes, [ML2], M = Co(II, Cu(II, and Ni(II, were synthesized and characterized by elemental analysis, magnetic susceptibility, FT-IR spectra, and thermal analysis techniques. The optical band gap of this ligand and its complexes were determined by UV-vis spectrophotometer in the wavelength range 300–800 nm. A decrease in the energy band gap of the [CoL2], [NiL2], and [CuL2] complexes has been observed compared with LH ligand. Temperature-dependent conductivity measurements showed that all samples behave like semiconductor. Activation energies calculated from Arrhenius plots showed that the conduction occurs via both intramolecular and the intermolecular processes.

  5. Compact focusing spectrometer: Visible (1 eV) to hard x-rays (200 keV)

    Science.gov (United States)

    Baronova, E. O.; Stepanenko, A. M.; Pereira, N. R.

    2014-11-01

    A low-cost spectrometer that covers a wide range of photon energies can be useful to teach spectroscopy, and for simple, rapid measurements of the photon spectrum produced by small plasma devices. The spectrometer here achieves its wide range, nominally from 1 eV to 200 keV, with a series of spherically and cylindrically bent gratings or crystals that all have the same shape and the same radius of curvature; they are complemented by matching apertures and diagnostics on the Rowland circle that serves as the circular part of the spectrometer's vacuum vessel. Spectral lines are easily identified with software that finds their positions from the dispersion of each diffractive element and the known energies of the lines.

  6. M1-E2 mixing ratios and B(E2) values for transitions in 131Xe

    International Nuclear Information System (INIS)

    The accuracies of M1-E2 mixing ratios calculated from the experimental conversion coefficients αi depend upon the accuracy with which the conversion coefficients are determined and also on the accuracy of the theoretical values. Recently a new calculation of ICCs by Band et al, BRICC has been published. The calculations are based on the relativistic DF method in which the exchange interactions between bound electrons and free electrons receding to infinity during the conversion process are treated exactly. Gerl et al showed that BRICC values are more closer to experimental values when compared to earlier theoretical values of Hager and Seltzer and Rosel. The availability of the BRICC values is expected to increase the accuracy with which the estimated quadrupole contents can be obtained

  7. Shedding Light on Dark Matter in Hot, Massive, and Awfully Complicated Cluster of Galaxies 1E0657-56

    International Nuclear Information System (INIS)

    The cluster of galaxies 1E0657-56 has been the subject of intense ongoing research in the last few years. This system is remarkably well-suited to addressing outstanding issues in both cosmology and fundamental physics. It is one of the hottest and most luminous X-ray clusters known and is unique in being a major supersonic cluster merger occurring nearly in the plane of the sky, earning it the nickname 'the Bullet Cluster'. In this talk I will present our measurements of the composition of this system, show the evidence for existence of dark matter, and describe limits that can be placed on the intrinsic properties of dark matter particles. In addition, I will explain how this cluster offers a serious challenge to MOdified Newtonian Dynamics (MOND) theories.

  8. Shedding Light on Dark Matter in Hot, Massive, and Awfully Complicated Cluster of Galaxies 1E0657-56

    Energy Technology Data Exchange (ETDEWEB)

    Bradac, Marusa

    2006-11-20

    The cluster of galaxies 1E0657-56 has been the subject of intense ongoing research in the last few years. This system is remarkably well-suited to addressing outstanding issues in both cosmology and fundamental physics. It is one of the hottest and most luminous X-ray clusters known and is unique in being a major supersonic cluster merger occurring nearly in the plane of the sky, earning it the nickname 'the Bullet Cluster'. In this talk I will present our measurements of the composition of this system, show the evidence for existence of dark matter, and describe limits that can be placed on the intrinsic properties of dark matter particles. In addition, I will explain how this cluster offers a serious challenge to MOdified Newtonian Dynamics (MOND) theories.

  9. Discovery of a new BL Lacertae object /1E 1402.3 + 0416/ with the Einstein Observatory

    Science.gov (United States)

    Stocke, J.; Liebert, J.; Stockman, H.; Danziger, J.; Lub, J.; Maccacaro, T.; Griffiths, R.; Giommi, P.

    1982-01-01

    It is noted that only one BL Lac object, designated 1E 1402.3 + 0416, has so far been discovered as part of an optical identification program for a complete sample of faint X-ray sources detected with the Einstein Observatory. Consistent with previously X-ray-discovered BL Lacs, this object is blue and radio weak (17 mJy at 6 cm). It is pointed out that the percentage of BL Lacs in the faint extragalactic X-ray sample (2%) is smaller than the percentage at higher X-ray fluxes (6%). Over the same range in X-ray flux, the percentage of emission-line active galaxy nuclei (QSO + Seyferts) rises from 40% to 74%). This is seen as suggesting that BL Lacs do not evolve in a manner similar to quasars and are, therefore, not substantial contributors to the X-ray background.

  10. Synthesis, Characterization and Anti-microbial Evaluation of Some 2-Iodo-N'-[(1E-Substituted Phenylmethylidene] Benzohydrazide Analogues

    Directory of Open Access Journals (Sweden)

    Harer Sunil L.

    2010-04-01

    Full Text Available Reaction of 2-iodo benzohydrazide (1 with appropriately substituted aromatic aldehyde in glacial acetic acid yielded corresponding 2-Iodo-N'-[(1E-Substituted Phenylmethylidene] Benzohydrazides (2. Structures of all the compounds (2 were established on the basis of elemental analysis and spectral data. These compounds were screened for anti-bacterial and anti-fungal activities at 200µg/0.1ml (T1 and 400µg/0.1ml (T2. Results obtained illustrates that the compounds F, C, D and G showed highly significant response while compound H showed less significant response for anti-microbial activity at both concentrations 200µg/0.1ml (T1 and 400µg/0.1ml (T2.

  11. A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer's Disease.

    Science.gov (United States)

    Vélez, Jorge I; Rivera, Dora; Mastronardi, Claudio A; Patel, Hardip R; Tobón, Carlos; Villegas, Andrés; Cai, Yeping; Easteal, Simon; Lopera, Francisco; Arcos-Burgos, Mauricio

    2016-01-01

    We previously reported age of onset (AOO) modifier genes in the world's largest pedigree segregating early-onset Alzheimer's disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and common functional variants located in those previously reported as AOO modifier loci were selected. Multiloci linear mixed-effects models were used to test the association between these variants and AOO. An exonic missense mutation in the G72 (DAOA) gene (rs2391191, P = 1.94 × 10(-4), P FDR = 9.34 × 10(-3)) was found to modify AOO in PSEN1 E280A AD. Nominal associations of missense mutations in the CLUAP1 (rs9790, P = 7.63 × 10(-3), P FDR = 0.1832) and EXOC2 (rs17136239, P = 0.0325, P FDR = 0.391) genes were also found. Previous studies have linked polymorphisms in the DAOA gene with the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD. Our findings strongly suggest that this new conspicuous functional AOO modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of AD. PMID:26949549

  12. A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Jorge I. Vélez

    2016-01-01

    Full Text Available We previously reported age of onset (AOO modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD, caused by the p.Glu280Ala (E280A mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and common functional variants located in those previously reported as AOO modifier loci were selected. Multiloci linear mixed-effects models were used to test the association between these variants and AOO. An exonic missense mutation in the G72 (DAOA gene (rs2391191, P = 1.94 × 10−4, PFDR = 9.34 × 10−3 was found to modify AOO in PSEN1 E280A AD. Nominal associations of missense mutations in the CLUAP1 (rs9790, P = 7.63 × 10−3, PFDR = 0.1832 and EXOC2 (rs17136239, P = 0.0325, PFDR = 0.391 genes were also found. Previous studies have linked polymorphisms in the DAOA gene with the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD. Our findings strongly suggest that this new conspicuous functional AOO modifier within the G72 (DAOA gene could be pivotal for understanding the genetic basis of AD.

  13. [6]-Shogaol Induces Ca2+ Signals by Activating the TRPV1 Channels in the Rat Insulinoma INS-1E Cells

    Directory of Open Access Journals (Sweden)

    Paola Rebellato

    2014-01-01

    Full Text Available Context [6]-shogaol is a vanilloid compound present in steamed ginger (Zingiber officinale, a commonly used spice. Pancreatic beta-cells respond to nutrients like glucose, amino acids and fatty acids, by an increase in the cytoplasmic free Ca2+ concentration ([Ca2+]i, which mediates diverse cellular processes in these cells. Some vanilloid compounds activate the transient receptor potential vanilloid receptor type 1 (TRPV1 channel. Objective We investigated whether [6]-shogaol could trigger Ca2+ signals in the beta-cell. Methods [Ca2+]i was measured from single INS-1E cells by microscope-based fluorometry using fura-2 as the Ca2+ indicator. Results In fura-2 loaded single rat insulinoma INS-1E cells, a widely used model of beta-cell, [6]-shogaol increased [Ca2+]i in a concentration-dependent manner. [Ca2+]i increase by [6]-shogaol was completely blocked when Ca2+ was omitted from the extracellular medium. Capsazepine, an inhibitor of the TRPV1 ion channel completely inhibited the [6]-shogaol-induced [Ca2+]i increase. [Ca2+]i increase obtained by 1 μM [6]-shogaol was greater than that obtained by 10 mM glucose. Moreover, a sub-stimulatory concentration of [6]-shogaol (300 nM, significantly enhanced the glucose-induced [Ca2+]i increase in these cells. Conclusion We conclude that [6]-shogaol induces Ca2+ signals in the beta-cell by activating the TRPV1 channels, and it sensitizes the beta-cells to stimulation by glucose.

  14. Teacher Education in Use of Computers. The Illinois Series on Educational Application of Computers, No. 1e.

    Science.gov (United States)

    Dennis, J. Richard

    Two model programs have been developed for preservice and inservice training of teachers in the instructional applications of computers. The preservice model features a background in computer science, foundations of instructional computing using a total school view and content specific view, a task-centered practicum in instructional computing,…

  15. Jets in quasars, microquasars and gamma-ray bursts

    OpenAIRE

    Mirabel, I.F.

    2000-01-01

    Relativistic outflows are common in accreting and forming black holes. Despite the enormous differences in scale, stellar-mass black holes in X-ray binaries and supermassive black holes in Galactic Nuclei produce jets with analogous properties. In both are observed two types of relativistic outflows: 1) quasi-steady compact jets with flat-spectrum, and 2) episodic large-scale ejections with steep-spectrum and apparent superluminal motions. Because of the short time scale of the phenomena in b...

  16. Optical results of the black hole microquasar SS 433

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    We present optical spectroscopic observations of SS 433 during different precessional and orbital phases.Our 2004,2007 and 2008 data provide us a good chance to study the variability of the Hα line at different orbital phases for nearly the same disk inclination.The data show that the Hα of SS 433 usually had a symmetric profile between orbital phases 0.25-0.75,while an asymmetric structure with a strong red peak was observed for other orbital phases.We suggest that the orbital variability of Hα emission is connected with accretion flow from the donor star to the accretion disk.In addition,we attribute the dramatic increase of Hα emission during our 2007 observational run,which had a time scale of one day,to the emergence of strong jets.

  17. Simultaneous multi-wavelength observations of Microquasars (the mine collaboration

    Directory of Open Access Journals (Sweden)

    Y. Fuchs

    2004-01-01

    Full Text Available Presentamos la colaboraci on internacional MINE (Multi- INTEGRAL NEtwork cuya meta es llevar a cabo observaciones en m ultiples longitudes de onda de microcuasares de forma simult anea al sat elite INTEGRAL. Los primeros resultados con GRS 1915+105 son muy esperanzadores y junto con los que se obtendr an en el futuro nos ayudar an a comprender la f sica de los fen omenos de acreci on y eyecci on relacionados con los sistemas binarios compactos.

  18. Hadronic gamma-ray production in microquasars with equatorial winds

    Directory of Open Access Journals (Sweden)

    Mariana Orellana

    2006-01-01

    Full Text Available Los microcuas ares son sistemas binarios con emisi on en rayos X vinculada a acreci on, en los cuales se han detectado chorros de part culas relativistas (jets a trav es de su emisi on en bandas de radio. La transferencia de masa al objeto compacto puede darse a trav es del viento ecuatorial de la primaria, cuando esta es de tipo espectral temprano, como es el caso del microcu asar LSI +61 303. En estos casos se dar a inevitablemente una interacci on entre el viento estelar y los jets, que puede resultar en la emisi on de fotones con muy alta energ a. El inter es por este escenario resurge a partir de la con rmaci on de los microcu asares como fuentes detectadas a energ as en el rango TeV. Presentamos un modelo para la emisi on de rayos gamma que se origina en la interacci on de protones relativistas del jet, con los protones fr os de un viento con nado en un disco circunestelar. Se calcul o tambi en, en forma simpli cada, la emisi on de los leptones secundarios. Teniendo en cuenta efectos de opacidad en la fost osfera, hemos podido estimar una curva de luz y un espectro que pueden ser contrastados con las mediciones de observatorios en altas energ as como MAGIC o HESS.

  19. Solar Technology Center

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, Bob

    2011-04-27

    The Department of Energy, Golden Field Office, awarded a grant to the UNLV Research Foundation (UNLVRF) on August 1, 2005 to develop a solar and renewable energy information center. The Solar Technology Center (STC) is to be developed in two phases, with Phase I consisting of all activities necessary to determine feasibility of the project, including design and engineering, identification of land access issues and permitting necessary to determine project viability without permanently disturbing the project site, and completion of a National Environmental Policy Act (NEPA) Environmental Assessment. Phase II is the installation of infrastructure and related structures, which leads to commencement of operations of the STC. The STC is located in the Boulder City designated 3,000-acre Eldorado Valley Energy Zone, approximately 15 miles southwest of downtown Boulder City and fronting on Eldorado Valley Drive. The 33-acre vacant parcel has been leased to the Nevada Test Site Development Corporation (NTSDC) by Boulder City to accommodate a planned facility that will be synergistic with present and planned energy projects in the Zone. The parcel will be developed by the UNLVRF. The NTSDC is the economic development arm of the UNLVRF. UNLVRF will be the entity responsible for overseeing the lease and the development project to assure compliance with the lease stipulations established by Boulder City. The STC will be operated and maintained by University of Nevada, Las Vegas (UNLV) and its Center for Energy Research (UNLV-CER). Land parcels in the Eldorado Valley Energy Zone near the 33-acre lease are committed to the construction and operation of an electrical grid connected solar energy production facility. Other projects supporting renewable and solar technologies have been developed within the energy zone, with several more developments in the horizon.

  20. Financing a Simulation Center.

    Science.gov (United States)

    Tsuda, Shawn; Mohsin, Adnan; Jones, Daniel

    2015-08-01

    As simulation-based training has become established within medical and health professional disciplines, skills training laboratories have become a standard in surgery training programs. In 2008, the American College of Surgeons and Association of Program Directors in Surgery developed a simulation-based surgical skills curriculum; the Residency Review Committee for Surgery of the Accreditation Council for Graduate Medical Education mandated access to skills laboratories for all surgery programs. Establishing a surgical skills laboratory and adapting the training curriculum requires a significant amount of resources. This article discusses the financial aspects of establishing a training center, from funding opportunities to budgeting considerations. PMID:26210971

  1. The MAGIC Data Center

    OpenAIRE

    Reichardt, Ignasi; Rico, Javier; Carmona, Emiliano; Contreras, Jose Luis; Cortina, Juan; Firpo, Roger; Font, Lluis; Moralejo, Abelardo; Nieto, Daniel; Oya, Igor; Reyes, Raquel de los

    2009-01-01

    The MAGIC I telescope produces currently around 100TByte of raw data per year that is calibrated and reduced on-site at the Observatorio del Roque de los Muchachos (La Palma). Since February 2007 most of the data have been stored and further processed in the Port d'Informacio Cientifica (PIC), Barcelona. This facility, which supports the GRID Tier 1 center for LHC in Spain, provides resources to give the entire MAGIC Collaboration access to the reduced telescope data. It is expected that the ...

  2. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT, J.

    2005-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include, for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security. To achieve our goals we have established a close alliance with applied mathematicians and computer scientists at Stony Brook and Columbia Universities.

  3. Study of thermal behavior of the adobe with the simulator DOE 2.1E; Estudio de comportamiento termico del adobe con el simulador DOE 2.1E

    Energy Technology Data Exchange (ETDEWEB)

    Luna, Anibal; Gallegos, Ricardo; Bojorquez, Gonzalo [Universidad Autonoma de Baja California, Mexicali, Baja California (Mexico)

    2000-07-01

    A thermal analysis of the envelope of one of the most used housing models for low income groups, as those offered by the Mexican Government is presented in this report. The building's thermal gain in walls was determined, using: concrete block, brick and adobe; and considering concrete of roofing, concrete floors, windows and doors equal in all the cases. The objective of this study is to know the contribution to the building's thermal load of each one of the materials applied. The calculation was conducted using the Doe 2.1E thermal simulator software, using meteorological data for the city of El Centro, California, USA. This was so, because there is no reliable weather data for the city of Mexicali, B.C., where the housing units are. Because of geographical proximity between of these cities the same data was used. The properties for each one of the three building materials were taken from specialized bibliography. It was determined that the housing built with adobe walls has thermal advantages over the units built with concrete block and brick. The adobe unit has a lower thermal load of 13% over the concrete block, and of 3.44% over the clay brick unit. [Spanish] Se presenta el analisis termico de la envolvente de uno de los modelos de casas mas utilizados en la construccion de viviendas de interes social en Mexico. Se determino la ganancia, termica del edificio por muros, aplicando: bloque de concreto, ladrillo de barro y adobe. Se considero techo, piso, ventanas y puertas iguales en todos los casos. El objetivo del estudio es conocer la distribucion de la carga termica segun los materiales aplicados. El calculo se realizo con el simulador termico DOE 2.1E con datos meteorologicos de la ciudad de El Centro, California, E. U., por no contar con datos de Mexicali, B. C.: debido a la proximidad y similitud topografica entre ambas ciudades se uso la misma informacion. Las propiedades aplicadas para cada uno de los tres materiales fueron tomadas de

  4. Recombination luminescence from H centers and conversion of H centers into I centers in alkali iodides

    International Nuclear Information System (INIS)

    The study is aimed at the search for H-plus-electron centers of luminescence and the investigation of the conversion of H- into I centers by the luminescence of H-plus-electron centers in alkali iodide crystals. KI, RbI and NaI crystals were studied at 12 K. H and F centers were created by irradiation with ultraviolet light corresponding to the absorption band of anion excitons. Then the excitation of electron centers by red light irradiation was followed. The spectra of stimulated recombination luminescence were studied. The luminescence of H-plus- electron centers had been observed and the conclusion was made that this center was formed on immobile H centers. In case of stable H centers the optically stimulated conversion of H centers into I centers occurs. The assumption is advanced on the spontaneous annihilation of near placed unstable F, H centers which leads to the creation of H-plus-electron luminescence centers and to the spontaneous H-I-centers conversion

  5. Solution structure of GxTX-1E, a high affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels†

    OpenAIRE

    Lee, Seungkyu; Milescu, Mirela; Jung, Hyun Ho; Lee, Ju Yeon; Bae, Chan Hyung; Lee, Chul Won; Kim, Ha Hyung; Swartz, Kenton J.; Kim, Jae Il

    2010-01-01

    GxTX-1E is a neurotoxin recently isolated from Plesiophrictus guangxiensis venom that inhibits the Kv2.1 channel in pancreatic β-cells. The sequence of the toxin is related to previously studied tarantula toxins that interact with the voltage sensors in Kv channels, and GxTX-1E interacts with the Kv2.1 channel with unusually high affinity, making it particularly useful for structural and mechanistic studies. Here we determined the three-dimensional solution structure of GxTX-1E using NMR spec...

  6. National Center on Family Homelessness

    Science.gov (United States)

    ... You are here Home National Center on Family Homelessness Center A staggering 2.5 million children are ... raise awareness of the current state of child homelessness in the United States, documents the number of ...

  7. Oceans and Human Health Center

    Science.gov (United States)

    ... through a deeper understanding of the causes of ocean-related health threats About Find out more about our Center ... research taking place at the University of Miami Oceans & Human Health Center More Gallery Check out our photo and ...

  8. Center for Beam Physics, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities.

  9. Italy INAF Data Center Report

    Science.gov (United States)

    Negusini, M.; Sarti, P.

    2013-01-01

    This report summarizes the activities of the Italian INAF VLBI Data Center. Our Data Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics.

  10. Dialysis centers - what to expect

    Science.gov (United States)

    ... what to expect; Renal replacement therapy - dialysis centers; End-stage renal disease - dialysis centers; Kidney failure - dialysis ... swells and the hand on that side feels cold Your hand gets cold, numb, or weak Also ...

  11. Contact Center Manager Administration (CCMA)

    Data.gov (United States)

    Social Security Administration — CCMA is the server that provides a browser-based tool for contact center administrators and supervisors. It is used to manage and configure contact center resources...

  12. Center for Beam Physics, 1992

    International Nuclear Information System (INIS)

    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities

  13. Center to Advance Palliative Care

    Science.gov (United States)

    ... Discussion Forum The IPAL Project Palliative Care Leadership Centers (PCLC) Member Resources National Seminar Quick Links Certification ... a Job Manage Job Posts About About The Center to Advance Palliative Care (CAPC) is a national ...

  14. Sustainable Biofuels Development Center

    Energy Technology Data Exchange (ETDEWEB)

    Reardon, Kenneth F. [Colorado State Univ., Fort Collins, CO (United States)

    2015-03-01

    The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

  15. Rapid guiding center calculations

    International Nuclear Information System (INIS)

    Premature loss of high energy particles, and in particular fusion alpha particles, is very deleterious in a fusion reactor. Because of this it is necessary to make long-time simulations, on the order of the alpha particle slowing down time, with a number of test particles sufficient to give predictions with reasonable statistical accuracy. Furthermore it is desirable to do this for a large number of equilibria with different characteristic magnetic field ripple, to best optimize engineering designs. In addition, modification of the particle distribution due to magnetohydrodynamic (MHD) modes such as the saw tooth mode present in the plasma can be important, and this effect requires additional simulation. Thus the large number of necessary simulations means any increase of computing speed in guiding center codes is an important improvement in predictive capability. Previous guiding center codes using numerical equilibria such as ORBIT evaluated the local field strength and ripple magnitude using Lagrangian interpolation on a grid. Evaluation of these quantities four times per time step (using a fourth order Runge-Kutta routine) constitutes the major computational effort of the code. In the present work the authors represent the field quantities through an expansion in terms of pseudo-cartesian coordinates formed from the magnetic coordinates. The simplicity of the representation gives four important advantages over previous methods

  16. The MAGIC Data Center

    CERN Document Server

    Reichardt, Ignasi; Carmona, Emiliano; Contreras, Jose Luis; Cortina, Juan; Firpo, Roger; Font, Lluis; Moralejo, Abelardo; Nieto, Daniel; Oya, Igor; Reyes, Raquel de los

    2009-01-01

    The MAGIC I telescope produces currently around 100TByte of raw data per year that is calibrated and reduced on-site at the Observatorio del Roque de los Muchachos (La Palma). Since February 2007 most of the data have been stored and further processed in the Port d'Informacio Cientifica (PIC), Barcelona. This facility, which supports the GRID Tier 1 center for LHC in Spain, provides resources to give the entire MAGIC Collaboration access to the reduced telescope data. It is expected that the data volume will increase by a factor 3 after the start-up of the second telescope, MAGIC II. The project to improve the MAGIC Data Center to meet these requirements is presented. In addition, we discuss the production of high level data products that will allow a more flexible analysis and will contribute to the international network of astronomical data (European Virtual Observatory). For this purpose, we will have to develop a new software able to adapt the analysis process to different data taking conditions, such as ...

  17. Patient-centered Radiology.

    Science.gov (United States)

    Itri, Jason N

    2015-10-01

    Patient-centered care (ie, care organized around the patient) is a model in which health care providers partner with patients and families to identify and satisfy patients' needs and preferences. In this model, providers respect patients' values and preferences, address their emotional and social needs, and involve them and their families in decision making. Radiologists have traditionally been characterized as "doctor-to-doctor" consultants who are distanced from patients and work within a culture that does not value patient centeredness. As medicine becomes more patient driven and the trajectory of health care is toward increasing patient self-reliance, radiologists must change the perception that they are merely consultants and become more active participants in patient care by embracing greater patient interaction. The traditional business model for radiology practices, which devalues interaction between patients and radiologists, must be transformed into a patient-centered model in which radiologists are reintegrated into direct patient care and imaging processes are reorganized around patients' needs and preferences. Expanding radiology's core assets to include direct patient care may be the most effective deterrent to the threat of commoditization. As the assault on the growth of Medicare spending continues, with medical imaging as a highly visible target, radiologists must adapt to the changing landscape by focusing on their most important consumer: the patient. This may yield substantial benefits in the form of improved quality and patient safety, reduced costs, higher-value care, improved patient outcomes, and greater patient and provider satisfaction. PMID:26466190

  18. Hyogo Hadron Therapy Center

    International Nuclear Information System (INIS)

    Hyogo Prefectural Government has decided and started construction of Hyogo Hadron Therapy Center in Harima Science Garden City, where is about 75 km away from Kobe City to the north-west. The center has injector, synchrotron, high energy beam transport system and treatment system. The accelerator complex can accelerate proton, helium, and carbon. The energy ranges are 70-230 MeV/u for proton and helium, and 70-320 MeV/u for the carbon. The beam intensity is required to satisfy the dose rate of 5 Gy/min. for treatment volume of 15cmφ field size and fully extended spread out Bragg peak (SOBP). The beam transport system consists of three horizontal ports, one vertical ports, and one 45deg oblique port for proton, helium and carbon beam, two isocentric gantry ports only for proton beam. A hospital within 50 beds is constructed with the site. Patient treatment will be started in the year 2001. (author)

  19. The Backgrounds Data Center

    Science.gov (United States)

    Snyder, W. A.; Gursky, H.; Heckathorn, H. M.; Lucke, R. L.; Berg, S. L.; Dombrowski, E. G.; Kessel, R. A.

    1993-01-01

    The Strategic Defense Initiative Organization has created data centers for midcourse, plumes, and backgrounds phenomenologies. The Backgrounds Data Center (BDC) has been designated as the prime archive for data collected by SDIO programs. The BDC maintains a Summary Catalog that contains 'metadata,' that is, information about data, such as when the data were obtained, what the spectral range of the data is, and what region of the Earth or sky was observed. Queries to this catalog result in a listing of all data sets (from all experiments in the Summary Catalog) that satisfy the specified criteria. Thus, the user can identify different experiments that made similar observations and order them from the BDC for analysis. On-site users can use the Science Analysis Facility (SAFE for this purpose. For some programs, the BDC maintains a Program Catalog, which can classify data in as many ways as desired (rather than just by position, time, and spectral range as in the Summary Catalog). For example, data sets could be tagged with such diverse parameters as solar illumination angle, signal level, or the value of a particular spectral ratio, as long as these quantities can be read from the digital record or calculated from it by the ingest program. All unclassified catalogs and unclassified data will be remotely accessible.

  20. Data center coolant switch

    Science.gov (United States)

    Iyengar, Madhusudan K.; Parida, Pritish R.; Schultz, Mark D.

    2015-10-06

    A data center cooling system is operated in a first mode; it has an indoor portion wherein heat is absorbed from components in the data center, and an outdoor heat exchanger portion wherein outside air is used to cool a first heat transfer fluid (e.g., water) present in at least the outdoor heat exchanger portion of the cooling system during the first mode. The first heat transfer fluid is a relatively high performance heat transfer fluid (as compared to the second fluid), and has a first heat transfer fluid freezing point. A determination is made that an appropriate time has been reached to switch from the first mode to a second mode. Based on this determination, the outdoor heat exchanger portion of the data cooling system is switched to a second heat transfer fluid, which is a relatively low performance heat transfer fluid, as compared to the first heat transfer fluid. It has a second heat transfer fluid freezing point lower than the first heat transfer fluid freezing point, and the second heat transfer fluid freezing point is sufficiently low to operate without freezing when the outdoor air temperature drops below a first predetermined relationship with the first heat transfer fluid freezing point.

  1. CURRICULUM GUIDE, CHILD CARE CENTERS.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    CALIFORNIA CHILD CARE CENTERS WERE ESTABLISHED IN 1943 TO SUPPLY SERVICES TO CHILDREN OF WORKING MOTHERS. THE CHILD CARE PROGRAM PROVIDES, WITHIN NURSERY AND SCHOOLAGE CENTERS, CARE AND EDUCATIONAL SUPERVISION FOR PRESCHOOL AND ELEMENTARY SCHOOL AGE CHILDREN. THE PHILOSOPHY OF THE CHILD CENTER PROGRAM IS BASED UPON THE BELIEF THAT EACH CHILD…

  2. On chains of centered valuations

    Directory of Open Access Journals (Sweden)

    Rachid Chibloun

    2003-01-01

    Full Text Available We study chains of centered valuations of a domain A and chains of centered valuations of A [X1,…,Xn] corresponding to valuations of A. Finally, we make some applications to chains of valuations centered on the same ideal of A [X1,…,Xn] and extending the same valuation of A.

  3. Neurovirulência e neuroinvasividade de herpesvírus bovinos tipos 1 e 5 em coelhos

    Directory of Open Access Journals (Sweden)

    Spilki Fernando R.

    2002-01-01

    Full Text Available Com o objetivo de avaliar a capacidade dos herpesvírus bovinos tipos 1 e 5 (BHV-1 e BHV-5 de invadir e replicar no sistema nervoso central (SNC (neuroinvasividade, bem como sua capacidade de induzir doença neurológica (neurovirulência, coelhos com 30 a 35 dias de idade foram inoculados com uma amostra do Herpesvírus da Encefalite Bovina (BHV-5; amostra EVI 88/95 ou com amostras de BHV-1 (Los Angeles ou Cooper, pelas vias intratecal (IT e intranasal (IN. A inoculação da amostra de BHV-5, tanto pela via IT como IN, induziu sinais clínicos neurológicos em 100% (12/12 dos coelhos inoculados. Os exames histopatológicos revelaram um quadro de meningoencefalite não-purulenta multifocal, caracterizada por gliose multifocal e infiltrados perivasculares. O vírus foi isolado de várias áreas do SNC desses animais. As amostras de BHV-1, quando inoculadas pela via IT, não foram neurovirulentas. A amostra Los Angeles de BHV-1, quando administrada pela via IN, induziu sinais respiratórios severos, além de sinais neurológicos em 57% (4/7 dos animais inoculados. Entretanto, o exame histopatológico destes quatro animais revelou vasculite e trombose no pulmão e cérebro, este último apresentando focos de necrose neuronal, porém sem lesões indicativas de encefalite. Isso sugere que os sinais neurológicos foram, provavelmente, conseqüentes a prejuízos no fluxo sangüíneo encefálico, e não a danos neuronais provocados pela inoculação desse vírus. A amostra Cooper de BHV-1, quando inoculada pela via IN, induziu apenas sinais leves de infecção respiratória. Estes resultados indicam que apenas a amostra de BHV-5 foi capaz de invadir e replicar no encéfalo dos coelhos quando inoculada tanto por via IN como IT, apresentando neuroinvasividade e neurovirulência. É possível que estas observações tenham relação com o fato de amostras de BHV-5 freqüentemente causarem encefalites, em contraposição a infecções pelo BHV-1, onde

  4. COMPUTATIONAL SCIENCE CENTER

    International Nuclear Information System (INIS)

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to bring together

  5. COMPUTATIONAL SCIENCE CENTER

    Energy Technology Data Exchange (ETDEWEB)

    DAVENPORT, J.

    2006-11-01

    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to

  6. Supernova Science Center

    Energy Technology Data Exchange (ETDEWEB)

    S. E. Woosley

    2008-05-05

    The Supernova Science Center (SNSC) was founded in 2001 to carry out theoretical and computational research leading to a better understanding of supernovae and related transients. The SNSC, a four-institutional collaboration, included scientists from LANL, LLNL, the University of Arizona (UA), and the University of California at Santa Cruz (UCSC). Intitially, the SNSC was funded for three years of operation, but in 2004 an opportunity was provided to submit a renewal proposal for two years. That proposal was funded and subsequently, at UCSC, a one year no-cost extension was granted. The total operational time of the SNSC was thus July 15, 2001 - July 15, 2007. This document summarizes the research and findings of the SNSC and provides a cummulative publication list.

  7. Industrial Assessment Center

    Energy Technology Data Exchange (ETDEWEB)

    J. Kelly Kissock; Becky Blust

    2007-04-17

    The University of Dayton (UD) performed energy assessments, trained students and supported USDOE objectives. In particular, the UD Industrial Assessment Center (IAC) performed 96 industrial energy assessment days for mid-sized manufacturers. The average identified and implemented savings on each assessment were $261,080 per year and $54,790 per year. The assessments served as direct training in industrial energy efficiency for 16 UD IAC students. The assessments also served as a mechanism for the UD IAC to understand manufacturing energy use and improve upon the science of manufacturing energy efficiency. Specific research results were published in 16 conference proceedings and journals, disseminated in 22 additional invited lectures, and shared with the industrial energy community through the UD IAC website.

  8. Industrial Assessment Center Program

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Dereje Agonafer

    2007-11-30

    The work described in this report was performed under the direction of the Industrial Assessment Center (IAC) at University of Texas at Arlington. The IAC at The University of Texas at Arlington is managed by Rutgers University under agreement with the United States Department of Energy Office of Industrial Technology, which financially supports the program. The objective of the IAC is to identify, evaluate, and recommend, through analysis of an industrial plant’s operations, opportunities to conserve energy and prevent pollution, thereby reducing the associated costs. IAC team members visit and survey the plant. Based upon observations made in the plant, preventive/corrective actions are recommended. At all times we try to offer specific and quantitative recommendations of cost savings, energy conservation, and pollution prevention to the plants we serve.

  9. Citizen centered design

    Directory of Open Access Journals (Sweden)

    Ingrid Mulder

    2015-11-01

    Full Text Available Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with bottom-up social innovation to reach meaningful design. The biggest challenge is indeed to embrace a new collaborative attitude, a participatory approach, and to have the proper infrastructure that supports this social fabric. Participatory design and transition management are future-oriented, address people and institutions. Only through understanding people in context and the corresponding dynamics, one is able to design for liveable and sustainable urban environments, embracing the human scale.

  10. Mi Pueblo Food Center

    Directory of Open Access Journals (Sweden)

    Alexis A. Babb

    2016-04-01

    Full Text Available This case describes a current growth opportunity for Mi Pueblo Food Center, a Hispanic grocery chain with locations throughout the Bay Area, California. The CEO of Mi Pueblo is contemplating opening a new store location in East Palo Alto, CA, which has been without a local, full-service grocery store for over 20 years. Case objectives are for students to develop an understanding of how the grocery industry operates, the risks and opportunities associated with opening a new grocery store location, and the impact on social, environmental, and economic sustainability. The SWOT (Strengths, Weaknesses, Opportunities, Threats framework is used to analyze whether or not it is feasible for Mi Pueblo to open a new location in East Palo Alto. This case may be used with students in graduate and advanced undergraduate courses.

  11. Interactive design center.

    Energy Technology Data Exchange (ETDEWEB)

    Pomplun, Alan R. (Sandia National Laboratories, Livermore, CA)

    2005-07-01

    Sandia's advanced computing resources provide researchers, engineers and analysts with the ability to develop and render highly detailed large-scale models and simulations. To take full advantage of these multi-million data point visualizations, display systems with comparable pixel counts are needed. The Interactive Design Center (IDC) is a second generation visualization theater designed to meet this need. The main display integrates twenty-seven projectors in a 9-wide by 3-high array with a total display resolution of more than 35 million pixels. Six individual SmartBoard displays offer interactive capabilities that include on-screen annotation and touch panel control of the facility's display systems. This report details the design, implementation and operation of this innovative facility.

  12. Concurrent engineering research center

    Science.gov (United States)

    Callahan, John R.

    1995-01-01

    The projects undertaken by The Concurrent Engineering Research Center (CERC) at West Virginia University are reported and summarized. CERC's participation in the Department of Defense's Defense Advanced Research Project relating to technology needed to improve the product development process is described, particularly in the area of advanced weapon systems. The efforts committed to improving collaboration among the diverse and distributed health care providers are reported, along with the research activities for NASA in Independent Software Verification and Validation. CERC also takes part in the electronic respirator certification initiated by The National Institute for Occupational Safety and Health, as well as in the efforts to find a solution to the problem of producing environment-friendly end-products for product developers worldwide. The 3M Fiber Metal Matrix Composite Model Factory Program is discussed. CERC technologies, facilities,and personnel-related issues are described, along with its library and technical services and recent publications.

  13. Abramovo Counterterrorism Training Center

    International Nuclear Information System (INIS)

    The U.S. government has been assisting the Russian Federation (RF) Ministry of Defense (MOD) for many years with nuclear weapons transportation security (NWTS) through the provision of specialized guard escort railcars and cargo railcars with integrated physical security and communication systems, armored transport vehicles, and armored escort vehicles. As a natural continuation of the NWTS program, a partnership has been formed to construct a training center that will provide counterterrorism training to personnel in all branches of the RF MOD. The Abramovo Counterterrorism Training Center (ACTC) is a multinational, multiagency project with funding from Canada, RF and the U.S. Departments of Defense and Energy. ACTC will be a facility where MOD personnel can conduct basic through advanced training in various security measures to protect Category IA material against the threat of terrorist attack. The training will enhance defense-in-depth principles by integrating MOD guard force personnel into the overall physical protection systems and improving their overall response time and neutralization capabilities. The ACTC project includes infrastructure improvements, renovation of existing buildings, construction of new buildings, construction of new training facilities, and provision of training and other equipment. Classroom training will be conducted in a renovated training building. Basic and intermediate training will be conducted on three different security training areas where various obstacles and static training devices will be constructed. The central element of ACTC, where advanced training will be held, is the 'autodrome,' a 3 km road along which various terrorist events can be staged to challenge MOD personnel in realistic and dynamic nuclear weapons transportation scenarios. This paper will address the ACTC project elements and the vision for training development and integrating this training into actual nuclear weapons transportation operations.

  14. Data-analysis center

    International Nuclear Information System (INIS)

    Changes at the data analysis center are summarized. The most dramatic change in the operation of the Data-Analysis Center (DAC) has been the implementation of a VAX cluster. The cluster is a network of loosely coupled VAX computers tied together with a high-speed network and sharing common disks. System software was enhanced with the addition of DECalc, a spread-sheet program for the VAX. EUNICE, a UNIX environment package that is layered on VMS, was added to VAX machine MPFG0. Networking capabilities in the DAC were significantly increased during 1984. Specifically, access to remote networks, such as TELENET, was made easier through the C-Division computers. In addition, the DAC acquired dial-out modems and software so that users could transfer files between DAC machines and other computers over phone lines. A major project in the data-acquisition section in the past year was a special-purpose multiprocessor system to analyze data generated at LAMPF. During the year requirements for the system have been defined, hardware for a prototype system (PDP-11/730s and Ethernet) has been selected, and the system software has been designed. During 1984 both Q replay and data acquisition using VAXes and the VMS operating system were fully implemented and released to users. VAX data acquisition was used successfully in experiments at EPICS at LAMPF, at the Bates Linear Accelerator in Massachusetts, and at the Bevalac at Lawrence Berkeley National Laboratory. The EPICS VAX-11/730 system was upgraded to a VAX-11/750 at the end of 1984 to improve on-line response and performance. Another VAX-11/750 is being purchased for HRS

  15. Aging, condition monitoring, and loss-of-coolant accident (LOCA) tests of Class 1E electrical cables: Summary of results

    International Nuclear Information System (INIS)

    This paper summarizes the results of aging, condition monitoring, and accident testing of Class 1E cables used in nuclear power generating stations. Three sets of cables were aged for up to 9 months under simultaneous thermal (≅ 100 degrees C) and radiation (≅0.10 kGy/hr) conditions. After the aging, the cables were exposed to a simulated accident consisting of high dose rate irradiation (≅6 kGy/hr) followed by a high temperature steam exposure. A fourth set of cables, which were unaged, were also exposed to the accident conditions. The cables that were aged for 3 months and then accident tested were subsequently exposed to a high temperature steam fragility test (up to 400 degrees C), while the cables that were aged for 6 months and then accident tested were subsequently exposed to a 1000-hour submergence test in a chemical solution. The results of the tests indicate that the feasibility of life extension of many popular nuclear power plant cable products is promising and that mechanical measurements (primarily elongation, modulus, and density) were more effective than electrical measurements for monitoring age-related degradation. In the high temperature steam test, ethylene propylene rubber (EPR) cable materials generally survived to higher temperatures than crosslinked polyolefin (XLPO) cable materials. In dielectric testing after the submergence testing, the XLPO materials performed better than the EPR materials. This paper presents some recent experimental data that are not yet available elsewhere and a summary of findings from the entire experimental program

  16. NuSTAR observations of X-ray bursts from the magnetar 1E 1048.1–5937

    International Nuclear Information System (INIS)

    We report the detection of eight bright X-ray bursts from the 6.5 s magnetar 1E 1048.1–5937, during a 2013 July observation campaign with the Nuclear Spectroscopic Telescope Array. We study the morphological and spectral properties of these bursts and their evolution with time. The bursts resulted in count rate increases by orders of magnitude, sometimes limited by the detector dead time, and showed blackbody spectra with kT ∼ 6-8 keV in the T90 duration of 1-4 s, similar to earlier bursts detected from the source. We find that the spectra during the tail of the bursts can be modeled with an absorbed blackbody with temperature decreasing with flux. The burst flux decays followed a power law of index 0.8-0.9. In the burst tail spectra, we detect a ∼13 keV emission feature, similar to those reported in previous bursts from this source as well as from other magnetars observed with the Rossi X-ray Timing Explorer. We explore possible origins of the spectral feature such as proton cyclotron emission, which implies a magnetic field strength of B ∼ 2 × 1015 G in the emission region. However, the consistency of the energy of the feature in different objects requires further explanation.

  17. Aging, condition monitoring, and loss-of-coolant accident (LOCA) tests of Class 1E electrical cables: Summary of results

    International Nuclear Information System (INIS)

    This paper summarizes the results of aging, condition monitoring, and accident testing of Class 1E cables used in nuclear power generating stations. Three sets of cables were aged for up to 9 months under simultaneous thermal (≅ 100C) and radiation (≅ 0.10 kGy/hr) conditions. After the aging, the cables were exposed to a simulated accident consisting of high dose rate irradiation (≅ 6 kGy/hr) followed by a high temperature steam exposure. A fourth set of cables, which were unaged, were also exposed to the accident conditions. The cables that were aged for 3 months and then accident tested were subsequently exposed to a high temperature steam fragility test (up to 400C), while the cables that were aged for 6 months and then accident tested were subsequently exposed to a 1,000-hour submergence test in a chemical solution. The results of the tests indicate that the feasibility of life extension of many popular nuclear power plant cable products is promising and that mechanical measurements (primarily elongation, modulus, and density) were more effective than electrical measurements for monitoring age-related degradation. In the high temperature steam test, ethylene propylene rubber (EPR) cable materials generally survived to higher temperatures than crosslinked polyolefin (XLPO) cable materials. In dielectric testing after the submergence testing, the XLPO materials performed better than the EPR materials. This paper presents some recent experimental data that are not yet available elsewhere and a summary of findings from the entire experimental program

  18. An ultra-bright, dust-obscured, millimeter-galaxy beyond the Bullet Cluster (1E0657-56)

    CERN Document Server

    Wilson, G W; Hughes, D; Ezawa, H; Austermann, J E; Doyle, S; Hernandez-Curiel, I; Kawabe, R; Kitayama, T; Kohno, K; Kuboi, A; Matsuo, H; Mauskopf, P D; Murakoshi, Y; Montana, A; Natarajan, P; Oshima, T; Ota, N; Perera, T; Rand, J; Scott, K S; Tanaka, K; Tsuboi, M; Williams, C C; Yun, M S

    2008-01-01

    Deep 1.1 mm continuum observations of the interacting galaxy-clusters 1E0657-56 (the Bullet Cluster) taken with the millimeter-wavelength camera AzTEC on the 10-m Atacama Submillimeter Telescope Experiment (ASTE), have revealed an extremely bright (S_1.1mm=15.9mJy) unresolved source. This source, MMJ065837-5557.0, lies close to a maximum in the density of underlying mass-distribution as traced by the weak-lensing analysis of Clowe et al. 2006, towards the larger of the two interacting clusters. A lensing-derived mass model for the Bullet Cluster shows a critical-line (caustic) of magnification very near the AzTEC source, likely providing a high boost (> 20) to its millimeter flux. We explore various scenarios to explain the colors, morphologies and positional offsets between the potential optical and IR counterparts, and their relationship with MMJ065837-5557.0. One interpretation is that MMJ065837-5557.0 is an individual distant LIRG, with multiple HST and Spitzer images due to the strong lensing by the Bull...

  19. Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition

    Science.gov (United States)

    Littlejohn, Mathew D.; Tiplady, Kathryn; Fink, Tania A.; Lehnert, Klaus; Lopdell, Thomas; Johnson, Thomas; Couldrey, Christine; Keehan, Mike; Sherlock, Richard G.; Harland, Chad; Scott, Andrew; Snell, Russell G.; Davis, Stephen R.; Spelman, Richard J.

    2016-01-01

    The mammary gland is a prolific lipogenic organ, synthesising copious amounts of triglycerides for secretion into milk. The fat content of milk varies widely both between and within species, and recent independent genome-wide association studies have highlighted a milk fat percentage quantitative trait locus (QTL) of large effect on bovine chromosome 5. Although both EPS8 and MGST1 have been proposed to underlie these signals, the causative status of these genes has not been functionally confirmed. To investigate this QTL in detail, we report genome sequence-based imputation and association mapping in a population of 64,244 taurine cattle. This analysis reveals a cluster of 17 non-coding variants spanning MGST1 that are highly associated with milk fat percentage, and a range of other milk composition traits. Further, we exploit a high-depth mammary RNA sequence dataset to conduct expression QTL (eQTL) mapping in 375 lactating cows, revealing a strong MGST1 eQTL underpinning these effects. These data demonstrate the utility of DNA and RNA sequence-based association mapping, and implicate MGST1, a gene with no obvious mechanistic relationship to milk composition regulation, as causally involved in these processes. PMID:27146958

  20. Prunella vulgaris Suppresses HG-Induced Vascular Inflammation via Nrf2/HO-1/eNOS Activation

    Directory of Open Access Journals (Sweden)

    Ho Sub Lee

    2012-01-01

    Full Text Available Vascular inflammation is an important factor which can promote diabetic complications. In this study, the inhibitory effects of aqueous extract from Prunella vulgaris (APV on high glucose (HG-induced expression of cell adhesion molecules in human umbilical vein endothelial cells (HUVEC are reported. APV decreased HG-induced expression of intercellular adhesion molecule-1 (ICAM-1, vascular cell adhesion molecule-1 (VCAM-1, and E-selectin. APV also dose-dependently inhibited HG-induced adhesion of HL-60 monocytic cells. APV suppressed p65 NF-κB activation in HG-treated cells. APV significantly inhibited the formation of intracellular reactive oxygen species (ROS. HG-stimulated HUVEC secreted gelatinases, however, APV inhibited it. APV induced Akt phosphorylation as well as activation of heme oxygenase-1 (HO-1, eNOS, and nuclear factor E2-related factor 2 (Nrf2, which may protect vascular inflammation caused by HG. In conclusion, APV exerts anti-inflammatory effect via inhibition of ROS/NF-κB pathway by inducing HO-1 and eNOS expression mediated by Nrf2, thereby suggesting that Prunella vulgaris may be a possible therapeutic approach to the inhibition of diabetic vascular diseases.

  1. Distance to the SNR CTB 109/AXP 1E 2259+586 by HI absorption and self-absorption

    CERN Document Server

    Tian, Wenwu; Li, Di

    2010-01-01

    We suggest a revised distance to the supernova remnant (SNR) G109.1-1.0 (CTB 109) and its associated anomalous X-ray pulsar (AXP) 1E 2259+586 by analyzing 21cm HI-line and 12CO-line spectra of CTB 109, HII region Sh 152, and the adjacent molecular cloud complex. CTB 109 has been established to be interacting with a large molecular cloud (recession velocity at v=-55 km s^-1). The highest radial velocities of absorption features towards CTB 109 (-56 km s^-1) and Sh 152 (-65 km s^-1) are larger than the recombination line velocity (-50 km s^-1) of Sh 152 demonstrating the velocity reversal within the Perseus arm. The molecular cloud has cold HI column density large enough to produce HI self-absorption (HISA) and HI narrow self-absorption (HINSA) if it was at the near side of the velocity reversal. Absence of both HISA and HINSA indicates that the cloud is at the far side of the velocity reversal within the Perseus Arm, so we obtain a distance for CTB 109 of 4+/-0.8 kpc. The new distance still leads to a normal e...

  2. Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition.

    Science.gov (United States)

    Littlejohn, Mathew D; Tiplady, Kathryn; Fink, Tania A; Lehnert, Klaus; Lopdell, Thomas; Johnson, Thomas; Couldrey, Christine; Keehan, Mike; Sherlock, Richard G; Harland, Chad; Scott, Andrew; Snell, Russell G; Davis, Stephen R; Spelman, Richard J

    2016-01-01

    The mammary gland is a prolific lipogenic organ, synthesising copious amounts of triglycerides for secretion into milk. The fat content of milk varies widely both between and within species, and recent independent genome-wide association studies have highlighted a milk fat percentage quantitative trait locus (QTL) of large effect on bovine chromosome 5. Although both EPS8 and MGST1 have been proposed to underlie these signals, the causative status of these genes has not been functionally confirmed. To investigate this QTL in detail, we report genome sequence-based imputation and association mapping in a population of 64,244 taurine cattle. This analysis reveals a cluster of 17 non-coding variants spanning MGST1 that are highly associated with milk fat percentage, and a range of other milk composition traits. Further, we exploit a high-depth mammary RNA sequence dataset to conduct expression QTL (eQTL) mapping in 375 lactating cows, revealing a strong MGST1 eQTL underpinning these effects. These data demonstrate the utility of DNA and RNA sequence-based association mapping, and implicate MGST1, a gene with no obvious mechanistic relationship to milk composition regulation, as causally involved in these processes. PMID:27146958

  3. A Comprehensive Study of the X-ray Bursts from the Magnetar Candidate 1E 2259+586

    CERN Document Server

    Gavriil, F P; Woods, P M; Gavriil, Fotis P.; Kaspi, Victoria M.; Woods, Peter M.

    2003-01-01

    We present a statistical analysis of the X-ray bursts observed from the 2002 June 18 outburst of the Anomalous X-ray Pulsar (AXP) 1E 2259+586, observed with the Proportional Counter Array (PCA) aboard the Rossi X-ray Timing Explorer. We show that the properties of these bursts are similar to those of Soft Gamma-Repeaters (SGRs). The similarities we find are the burst durations follow a log-normal distribution which peaks at 99 ms, the differential burst fluence distribution is well described by a power law of index -1.7, the burst fluences are positively correlated with the burst durations, the distribution of waiting times is well described by a log-normal distribution of mean 47 s, and the bursts are generally asymmetric with faster rise than fall times. However, we find several quantitative differences between the AXP and SGR bursts. Specifically, the AXP bursts we observed exhibit a wider range of durations, the correlation between burst fluence and duration is flatter than for SGRs, the observed AXP burs...

  4. Application of Escherichia coli phage K1E DNA-dependent RNA polymerase for in vitro RNA synthesis and in vivo protein production in Bacillus megaterium.

    Science.gov (United States)

    Stammen, Simon; Schuller, Franziska; Dietrich, Sylvia; Gamer, Martin; Biedendieck, Rebekka; Jahn, Dieter

    2010-09-01

    Gene "7" of Escherichia coli phage K1E was proposed to encode a novel DNA-dependent RNA polymerase (RNAP). The corresponding protein was produced recombinantly, purified to apparent homogeneity via affinity chromatography, and successfully employed for in vitro RNA synthesis. Optimal assay conditions (pH 8, 37 degrees C, 10 mM magnesium chloride and 1.3 mM spermidine) were established. The corresponding promoter regions were identified on the phage genome and summarized in a sequence logo. Surprisingly, next to K1E promoters, the SP6 promoter was also recognized efficiently in vitro by K1E RNAP, while the T7 RNAP promoter was not recognized at all. Based on these results, a system for high-yield in vitro RNA synthesis using K1E RNAP was established. The template plasmid is a pUC18 derivative, which enables blue/white screening for positive cloning of the target DNA. Production of more than 5 microg of purified RNA per microgram plasmid DNA was achieved. Finally, in vivo protein production systems for Bacillus megaterium were established based on K1E and SP6 phage RNAP transcription. Up to 61.4 mg g (CDW) (-1) (K1E RNAP) of the reporter protein Gfp was produced in shaking flask cultures of B. megaterium. PMID:20596705

  5. Taking the center to market.

    Science.gov (United States)

    Roberts, J; Roberts, T

    1985-01-01

    Community mental health centers have seldom been involved in marketing their services. Marketing is defined as responding sensitively to human needs, not hucksterism, and is an appropriate activity for centers. Centers are vulnerable because of declining federal funding and in order to serve the poor, must also service other populations with greater ability to pay for services or face retrenchment. Over the past twenty years, locally controlled centers have broadened their missions to serve many types of personal and family problems, not just the chronically ill. Centers should omit "mental health" for their names because of the stigma. Guidelines for creation of a positive image including name and logo selection, color, open houses, and ad campaigns are given using Madison Center (formerly the Mental Health Center of St. Joseph County) as a case study. Reactions of other providers, creative delivery of services through consultation and education, market segmentation and message levels of advertising are also discussed. PMID:3830554

  6. Launch Vehicle Control Center Architectures

    Science.gov (United States)

    Watson, Michael D.; Epps, Amy; Woodruff, Van; Vachon, Michael Jacob; Monreal, Julio; Williams, Randall; McLaughlin, Tom

    2014-01-01

    This analysis is a survey of control center architectures of the NASA Space Launch System (SLS), United Launch Alliance (ULA) Atlas V and Delta IV, and the European Space Agency (ESA) Ariane 5. Each of these control center architectures have similarities in basic structure, and differences in functional distribution of responsibilities for the phases of operations: (a) Launch vehicles in the international community vary greatly in configuration and process; (b) Each launch site has a unique processing flow based on the specific configurations; (c) Launch and flight operations are managed through a set of control centers associated with each launch site, however the flight operations may be a different control center than the launch center; and (d) The engineering support centers are primarily located at the design center with a small engineering support team at the launch site.

  7. The Lathrop Wells volcanic center

    International Nuclear Information System (INIS)

    The Lathrop Wells volcanic center is located 20 km south of the potential Yucca Mountain site, at the south end of the Yucca Mountain range. This paper discusses a detailed Study Plan which was prepared describing planned geochronology and field studies to assess the chronology of the Lathrop Wells volcanic center and other Quaternary volcanic centers in the region. A paper was published discussing the geomorphic and soil evidence for a late Pleistocene or Holoceno age for the main cone of the center. The purpose of this paper was to expose the ideas concerning the age of the Lathrop Wells center to scientific scrutiny. Additionally, field evidence was described suggesting the Lathrop Wells center may have formed from multiple eruptive events with significant intervals of no activity between events. This interpretation breaks with established convention in the volcanological literature that small volume basalt centers are monogenetic

  8. Centering Our Stories: Applying Spatial Metaphors to Writing Center Publicity

    OpenAIRE

    Nall, Stacy O

    2014-01-01

    This presentation at the 2014 Conference on College Composition and Communication (CCCC) discusses how writing centers can use digital spaces to position themselves as assets to their campus and local communities. While most writing centers have pages on their universities’ websites, there continue to be new ways that writing centers can take advantage of these spaces to make their work more visible to wider publics. One way they can do so, the presenter suggests, is through publishing storie...

  9. Interstellar HOCN in the Galactic center region

    CERN Document Server

    Bruenken, S; Martin, S; Verheyen, L; Menten, K M

    2010-01-01

    Aims. Our aim is to confirm the interstellar detection of cyanic acid, HOCN, in the Galactic center clouds. It has previously been tentatively detected only in Sgr B2(OH). Methods. We used a complete line survey of the hot cores Sgr B2(N) and (M) in the 3 mm range, complemented by additional observations carried out with the IRAM 30 m telescope at selected frequencies in the 2 mm band and towards four additional positions in the Sgr B2 cloud complex in the 2 and 3 mm bands. The spectral survey was analysed in the local thermodynamical equilibrium approximation (LTE) by modeling the emission of all identified molecules simultaneously. This allowed us to distinguish weak features of HOCN from the rich line spectrum observed in Sgr B2(N) and (M). Lines of the more stable (by 1.1 eV) isomer isocyanic acid, HNCO, in these sources, as well as those of HOCN and HNCO towards the other positions, were analysed in the LTE approximation as well. Results. Four transitions of HOCN were detected in a quiescent molecular cl...

  10. Crystallization and preliminary X-ray diffraction studies of AsaP1_E294A and AsaP1_E294Q, two inactive mutants of the toxic zinc metallopeptidase AsaP1 from Aeromonas salmonicida subsp. achromogenes

    OpenAIRE

    Bogdanović, Xenia; Singh, Rajesh Kumar; Hentschke, Johanna; Gudmundsdóttir, Bjarnheidur K.; Hinrichs, Winfried

    2009-01-01

    Crystallization and preliminary X-ray diffraction studies of AsaP1_E294A and AsaP1_E294Q, two inactive mutants of the toxic zinc metallopeptidase AsaP1 from A. salmonicida subsp. achromogenes, are reported.

  11. Sunyaev-Zel'Dovich effect observations of the bullet cluster (1E 0657-56) with APEX-SZ

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, N.W.; Lanting, T.; Ade, P.A.R.; Basu, K.; Bender, A.N.; Benson, B.A.; Bertoldi, F.; Cho, H.-M.; Chon, G.; Clarke, J.; Dobbs, M.; Ferrusca, D.; Gusten, R.; Holzapfel, W.L.; Kovacs, A.; Kennedy, J.; Kermish, Z.; Kneissl, R.; Lee, A.T.; Lueker, M.; Mehl, J.; Menten, K.M.; Muders, D.; Nord, M.; Pacaud, F.; Plagge, T.; Reichardt, C.; Richards, P.L.; Schaaf, R.; Schilke, P.; Schuller, F.; Schwan, D.; Spieler, H.; Tucker, C.; Weiss, A.; Zahn, O.

    2008-07-25

    We present observations of the Sunyaev-Zel'dovich effect (SZE) in the Bullet cluster (1E 0657-56) using the APEX-SZ instrument at 150 GHz with a resolution of 1'. The main results are maps of the SZE in this massive, merging galaxy cluster. The cluster is detected with 23 sigma significance within the central 1' radius of the source position. The SZE map has a broadly similar morphology to that in existing X-ray maps of this system, and we find no evidence for significant contamination of the SZE emission by radio or IR sources. In order to make simple quantitative comparisons with cluster gas models derived from X-ray observations, we fit our data to an isothermal elliptical beta model, despite the inadequacy of such a model for this complex merging system. With an X-ray derived prior on the power-law index, beta = 1.04+0.16-0.10, we find a core radius rc = 142" +- 18", an axial ratio of 0.889 +- 0.072, and a central temperature decrement of -771 +- 71 muKCMB, including a +-5.5percent flux calibration uncertainty. Combining the APEX-SZ map with a map of projected electron surface density from Chandra X-ray observations, we determine the mass-weighted temperature of the cluster gas to be Tmg = 10.8 +- 0.9 keV, significantly lower than some previously reported X-ray spectroscopic temperatures. Under the assumption of an isothermal cluster gas distribution in hydrostatic equilibrium, we compute the gas mass fraction for prolate and oblate spheroidal geometries and find it to be consistent with previous results from X-ray and weak-lensing observations. This work is the first result from the APEX-SZ experiment and represents the first reported scientific result from observations with a large array of multiplexed superconducting transition-edge sensor bolometers.

  12. Influence of organic ions on DNA damage induced by 1 eV to 60 keV electrons

    Science.gov (United States)

    Zheng, Yi; Sanche, Léon

    2010-10-01

    We report the results of a study on the influence of organic salts on the induction of single strand breaks (SSBs) and double strand breaks (DSBs) in DNA by electrons of 1 eV to 60 keV. Plasmid DNA films are prepared with two different concentrations of organic salts, by varying the amount of the TE buffer (Tris-HCl and EDTA) in the films with ratio of 1:1 and 6:1 Tris ions to DNA nucleotide. The films are bombarded with electrons of 1, 10, 100, and 60 000 eV under vacuum. The damage to the 3197 base-pair plasmid is analyzed ex vacuo by agarose gel electrophoresis. The highest yields are reached at 100 eV and the lowest ones at 60 keV. The ratios of SSB to DSB are surprisingly low at 10 eV (˜4.3) at both salt concentrations, and comparable to the ratios measured with 100 eV electrons. At all characteristic electron energies, the yields of SSB and DSB are found to be higher for the DNA having the lowest salt concentration. However, the organic salts are more efficient at protecting DNA against the damage induced by 1 and 10 eV electrons. DNA damage and protection by organic ions are discussed in terms of mechanisms operative at each electron energy. It is suggested that these ions create additional electric fields within the groove of DNA, which modify the resonance parameter of 1 and 10 eV electrons, namely, by reducing the electron capture cross-section of basic DNA units and the lifetime of corresponding transient anions. An interstrand electron transfer mechanism is proposed to explain the low ratios for the yields of SSB to those of DSB produced by 10 eV electrons.

  13. 'Motor control center obsolescence'

    International Nuclear Information System (INIS)

    A significant and growing problem within the global nuclear industry is the aging of motor control center (MCC) components. MCC's have a very important role in the safety and critical to generation requirements of a nuclear power plant. Although many OEM's MCC's such as ITE/Telemechanique, GE, Westinghouse, Cutler Hammer, Klockner Moeller, etc. have been used throughout the global nuclear industry, they all have one common aspect obsolescence. Obsolescence of various components within the MCC's such as molded case circuit breakers, starters, relays, heaters, contactors, etc. are impacting the reliability of the MCC to serve its intended function. The paper will discuss the options which the nuclear industry is faced with to increase the reliability of the MCC's while maintaining design control, qualification and meeting budget constraints. The options as listed below shall be discussed in detail with examples to enhance the readers understanding of the situation: 1) Component by component replacement: The hurdles associated with trying to find equivalent components to replace the obsolete components while still worki (mechanically and electrically) in the original cubicle will be presented. 2) Complete MCC cubicle with new internal components replacement: The process of supplying a replacement cubicle, with all new internal components and new door to replace the original cubicle will be discussed. The presentation will conclude with a comparison of the advantages and dis-advantages of the two methods to bring the MCC to an as new condition with the overall goal of increasing reliability. (author)

  14. Kennedy Space Center

    Science.gov (United States)

    Griffin, Amanda

    2012-01-01

    Among 2011's many accomplishments, we safely retired the Space Shuttle Program after 30 incredible years; completed the International Space Station and are taking steps to enable it to reach its full potential as a multi-purpose laboratory; and helped to expand scientific knowledge with missions like Aquarius, GRAIL, and the Mars Science Laboratory. Responding to national budget challenges, we are prioritizing critical capabilities and divesting ourselves of assets no longer needed for NASA's future exploration programs. Since these facilities do not have to be maintained or demolished, the government saves money. At the same time, our commercial partners save money because they do not have to build new facilities. It is a win-win for everyone. Moving forward, 2012 will be even more historically significant as we celebrate the 50th Anniversary of Kennedy Space Center. In the coming year, KSC will facilitate commercial transportation to low-Earth orbit and support the evolution of the Space Launch System and Orion crew vehicle as they ready for exploration missions, which will shape how human beings view the universe. While NASA's Vision is to lead scientific and technological advances in aeronautics and space for a Nation on the frontier of discovery KSC's vision is to be the world's preeminent launch complex for government and commercial space access, enabling the world to explore and work in space. KSC's Mission is to safely manage, develop, integrate, and sustain space systems through partnerships that enable innovative, diverse access to space and inspires the Nation's future explorers.

  15. Energetics Manufacturing Technology Center (EMTC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Energetics Manufacturing Technology Center (EMTC), established in 1994 by the Office of Naval Research (ONR) Manufacturing Technology (ManTech) Program, is Navy...

  16. Center for Environmental Health Sciences

    Data.gov (United States)

    Federal Laboratory Consortium — The primary research objective of the Center for Environmental Health Sciences (CEHS) at the University of Montana is to advance knowledge of environmental impacts...

  17. Consolidated Copayment Processing Center (CCPC)

    Data.gov (United States)

    Department of Veterans Affairs — The Consolidated Copayment Processing Center (CCPC) database contains Veteran patient contact and billing information in order to support the printing and mailing...

  18. Danish Chinese Center for Nanometals

    DEFF Research Database (Denmark)

    Winther, Grethe

    The Danish-Chinese Center for Nanometals is funded by the Danish National Research Foundation and the National Natural Science Foundation of China. The Chinese partners in the Center are Institute of Metal Research in Shenyang, Tsinghua University and Chongqing University. The Danish part of the...... Center is located at Risø DTU. The Center investigates metals, including light metals and steels, with internal length scales ranging from a few nanometers to a few micrometers. The structural morphologies studied are highly diverse, including structures composed of grain boundaries, twins and...

  19. Center for Neuroscience & Regenerative Medicine

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Neuroscience and Regenerative Medicine (CNRM) was established as a collaborative intramural federal program involving the U.S. Department of Defense...

  20. Satellite medical centers project

    Science.gov (United States)

    Aggarwal, Arvind

    2002-08-01

    World class health care for common man at low affordable cost: anywhere, anytime The project envisages to set up a national network of satellite Medical centers. Each SMC would be manned by doctors, nurses and technicians, six doctors, six nurses, six technicians would be required to provide 24 hour cover, each SMC would operate 24 hours x 7 days. It would be equipped with the Digital telemedicine devices for capturing clinical patient information and investigations in the form of voice, images and data and create an audiovisual text file - a virtual Digital patient. Through the broad band connectivity the virtual patient can be sent to the central hub, manned by specialists, specialists from several specialists sitting together can view the virtual patient and provide a specialized opinion, they can see the virtual patient, see the examination on line through video conference or even PCs, talk to the patient and the doctor at the SMC and controlle capturing of information during examination and investigations of the patient at the SMC - thus creating a virtual Digital consultant at the SMC. Central hub shall be connected to the doctors and consultants in remote locations or tertiary care hospitals any where in the world, thus creating a virtual hub the hierarchical system shall provide upgradation of knowledge to thedoctors in central hub and smc and thus continued medical education and benefit the patient thru the world class treatment in the smc located at his door step. SMC shall be set up by franchisee who shall get safe business opportunity with high returns, patients shall get Low cost user friendly worldclass health care anywhere anytime, Doctors can get better meaningful selfemplyment with better earnings, flexibility of working time and place. SMC shall provide a wide variety of services from primary care to world class Global consultation for difficult patients.

  1. ROSAT Science Data Center

    Science.gov (United States)

    Murray, Stephen; Pisarski, Ryszard L. (Technical Monitor)

    2001-01-01

    This report provides a summary of the Smithsonian Astrophysical Observatory (SAO) ROSAT SCIENCE DATA CENTER (RSDC) activities for the recent years of our contract. Details have already been reported in the monthly reports. The SAO was responsible for the High Resolution Imager (HRI) detector on ROSAT. We also provided and supported the HRI standard analysis software used in the pipeline processing (SASS). Working with our colleagues at the Max Planck in Garching Germany (MPE), we fixed bugs and provided enhancements. The last major effort in this area was the port from VMS/VAX to VMS/ALPHA architecture. In 1998, a timing bug was found in the HRI standard processing system which degraded the positional accuracy because events accessed incorrect aspect solutions. The bug was fixed and we developed off-line correction routines and provided them to the community. The Post Reduction Off-line Software (PROS) package was developed by SAO and runs in the IRAF environment. Although in recent years PROS was not a contractual responsibility of the RSDC, we continued to maintain the system and provided new capabilities such as the ability to deal with simulated AXAF data in preparation for the NASA call for proposals for Chandra. Our most recent activities in this area included the debugging necessary for newer versions of IRAF which broke some of our software. At SAO we have an operating version of PROS and hope to release a patch even though almost all functionality that was lost was subsequently recovered via an IRAF patch (i.e. most of our problems were caused by an IRAF bug).

  2. APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.

    Science.gov (United States)

    Vélez, J I; Lopera, F; Sepulveda-Falla, D; Patel, H R; Johar, A S; Chuah, A; Tobón, C; Rivera, D; Villegas, A; Cai, Y; Peng, K; Arkell, R; Castellanos, F X; Andrews, S J; Silva Lara, M F; Creagh, P K; Easteal, S; de Leon, J; Wong, M L; Licinio, J; Mastronardi, C A; Arcos-Burgos, M

    2016-07-01

    Alzheimer's disease (AD) age of onset (ADAOO) varies greatly between individuals, with unique causal mutations suggesting the role of modifying genetic and environmental interactions. We analyzed ~50 000 common and rare functional genomic variants from 71 individuals of the 'Paisa' pedigree, the world's largest pedigree segregating a severe form of early-onset AD, who were affected carriers of the fully penetrant E280A mutation in the presenilin-1 (PSEN1) gene. Affected carriers with ages at the extremes of the ADAOO distribution (30s-70s age range), and linear mixed-effects models were used to build single-locus regression models outlining the ADAOO. We identified the rs7412 (APOE*E2 allele) as a whole exome-wide ADAOO modifier that delays ADAOO by ~12 years (β=11.74, 95% confidence interval (CI): 8.07-15.41, P=6.31 × 10(-8), PFDR=2.48 × 10(-3)). Subsequently, to evaluate comprehensively the APOE (apolipoprotein E) haplotype variants (E1/E2/E3/E4), the markers rs7412 and rs429358 were genotyped in 93 AD affected carriers of the E280A mutation. We found that the APOE*E2 allele, and not APOE*E4, modifies ADAOO in carriers of the E280A mutation (β=8.24, 95% CI: 4.45-12.01, P=3.84 × 10(-5)). Exploratory linear mixed-effects multilocus analysis suggested that other functional variants harbored in genes involved in cell proliferation, protein degradation, apoptotic and immune dysregulation processes (i.e., GPR20, TRIM22, FCRL5, AOAH, PINLYP, IFI16, RC3H1 and DFNA5) might interact with the APOE*E2 allele. Interestingly, suggestive evidence as an ADAOO modifier was found for one of these variants (GPR20) in a set of patients with sporadic AD from the Paisa genetic isolate. This is the first study demonstrating that the APOE*E2 allele modifies the natural history of AD typified by the age of onset in E280A mutation carriers. To the best of our knowledge, this is the largest analyzed sample of patients with a unique mutation sharing uniform environment. Formal

  3. Chandra and XMM-Newton study of the supernova remnant Kes 73 hosting the magnetar 1E 1841-045

    International Nuclear Information System (INIS)

    We present a Chandra and XMM-Newton study of the supernova remnant (SNR) Kes 73 hosting the anomalous X-ray pulsar 1E 1841–045. The Chandra image reveals clumpy structures across the remnant with enhanced emission along the western rim. The X-ray emission fills the radio shell and spatially correlates with the infrared image. The global X-ray spectrum is described by a two-component thermal model with a column density N H = 2.6−0.3+0.4×1022 cm–2 and a total luminosity of LX = 3.3−0.5+0.7×1037 erg s–1 (0.5-10 keV, at an assumed distance of 8.5 kpc). The soft component is characterized by a temperature kTs = 0.5−0.2+0.1 keV, a high ionization timescale, and enhanced Si and S abundances, suggesting emission that is dominated by shocked ejecta. The hard component has a temperature kTh = 1.6−0.7+0.8 keV, a relatively low ionization timescale, and mostly solar abundances suggesting emission that is dominated by interstellar/circumstellar shocked material. A spatially resolved spectroscopy study reveals no significant variations in the spectral properties. We infer an SNR age ranging between 750 yr and 2100 yr, an explosion energy of 3.0−1.8+2.8×1050 erg and a shock velocity of (1.2 ± 0.3)×103 km s–1 (under the Sedov phase assumption). We also discuss the possible scenario for Kes 73 expanding into the late red-supergiant wind phase of its massive progenitor. Comparing the inferred metal abundances to core-collapse nucleosynthesis model yields, we estimate a progenitor mass ≳20 M ☉, adding a candidate to the growing list of highly magnetized neutron stars proposed to be associated with very massive progenitors.

  4. Identification of two novel mutations, PSEN1 E280K and PRNP G127S, in a Malaysian family

    Directory of Open Access Journals (Sweden)

    Ch’ng GS

    2015-09-01

    Full Text Available Gaik-Siew Ch’ng,1,* Seong Soo A An,2,* Sun Oh Bae,2 Eva Bagyinszky,2 SangYun Kim3,41Department of Genetics, Kuala Lumpur Hospital, Malaysia; 2Department of Bionano Technology, Gachon University, 3Department of Neurology, Seoul National University College of Medicine, 4Seoul National University Bundang Hospital, South Korea*These authors contributed equally to this workAbstract: Alzheimer’s disease (AD is the most common form of dementia, which can be categorized into two main forms: early onset AD and late onset AD. The genetic background of early onset AD is well understood, and three genes, the APP, PSEN1, and PSEN2 have been identified as causative genes. In the current study, we tested three siblings from Malaysia who were diagnosed with early onset dementia, as well as their available family members. The family history was positive as their deceased father was similarly affected. Patients were tested for mutations in APP, PSEN1, PSEN2, and PRNP. A novel variant, E280K, was discovered in exon 8 of PSEN1 in the three siblings. In silico analyses with SIFT, SNAP, and PolyPhen2 prediction tools and three-dimensional modeling were performed, and the results suggested that the mutation is probably a pathogenic variant. Two additional pathogenic mutations were previously been described for codon 280, E280A, and E280G, which could support the importance of the E280 residue in the PS1 protein contributing to the pathogenic nature of E280K. Additional ten family members were screened for the E280K mutation, and all of them were negative. Six of them presented with a variety of neuropsychiatric symptoms, including learning disabilities, epilepsy, and schizophrenia, while four family members were asymptomatic. A novel PRNP G127S mutation was found in a step-niece of the three siblings harboring the PSEN1 E280K mutation. In silico predictions for PRNP G127S mutation suggested that this might be possibly a damaging variant. Additional studies to

  5. 78 FR 69173 - University Transportation Centers Program

    Science.gov (United States)

    2013-11-18

    ... Research and Innovative Technology Administration University Transportation Centers Program AGENCY... opportunity to submit applications for a grant as a Regional Center in the University Transportation Centers... will solicit competitive grant applications for two regional university transportation centers,...

  6. Clean Energy Application Center

    Energy Technology Data Exchange (ETDEWEB)

    Freihaut, Jim

    2013-09-30

    The Mid Atlantic Clean Energy Application Center (MACEAC), managed by The Penn State College of Engineering, serves the six states in the Mid-Atlantic region (Pennsylvania, New Jersey, Delaware, Maryland, Virginia and West Virginia) plus the District of Columbia. The goals of the Mid-Atlantic CEAC are to promote the adoption of Combined Heat and Power (CHP), Waste Heat Recovery (WHR) and District Energy Systems (DES) in the Mid Atlantic area through education and technical support to more than 1,200 regional industry and government representatives in the region. The successful promotion of these technologies by the MACEAC was accomplished through the following efforts; (1)The MACEAC developed a series of technology transfer networks with State energy and environmental offices, Association of Energy Engineers local chapters, local community development organizations, utilities and, Penn State Department of Architectural Engineering alumni and their firms to effectively educate local practitioners about the energy utilization, environmental and economic advantages of CHP, WHR and DES; (2) Completed assessments of the regional technical and market potential for CHP, WHR and DE technologies application in the context of state specific energy prices, state energy and efficiency portfolio development. The studies were completed for Pennsylvania, New Jersey and Maryland and included a set of incentive adoption probability models used as a to guide during implementation discussions with State energy policy makers; (3) Using the technical and market assessments and adoption incentive models, the Mid Atlantic CEAC developed regional strategic action plans for the promotion of CHP Application technology for Pennsylvania, New Jersey and Maryland; (4) The CHP market assessment and incentive adoption model information was discussed, on a continuing basis, with relevant state agencies, policy makers and Public Utility Commission organizations resulting in CHP favorable incentive

  7. Crystallization and preliminary X-ray diffraction studies of AsaP1-E294A and AsaP1-E294Q, two inactive mutants of the toxic zinc metallopeptidase AsaP1 from Aeromonas salmonicida subsp. achromogenes

    International Nuclear Information System (INIS)

    Crystallization and preliminary X-ray diffraction studies of AsaP1-E294A and AsaP1-E294Q, two inactive mutants of the toxic zinc metallopeptidase AsaP1 from A. salmonicida subsp. achromogenes, are reported. Two mutants of the toxic extracellular zinc endopeptidase AsaP1 (AsaP1-E294Q and AsaP1-E294A) of Aeromonas salmonicida subsp. achromogenes were expressed in Escherichia coli and crystallized by the vapour-diffusion method. Crystals were obtained using several precipitants and different protein concentrations. Protein crystals were found in a monoclinic (C2) as well as an orthorhombic (P212121) space group. The crystals belonging to the monoclinic space group C2 had unit-cell parameters a = 103.4, b = 70.9, c = 54.9 Å, β = 109.3° for AsaP1-E294A, and a = 98.5, b = 74.5, c = 54.7 Å, β = 112.4° for AsaP1-E294Q. The unit-cell parameters of the orthorhombic crystal obtained for AsaP1-E294A were a = 57.9, b = 60.2, c = 183.6 Å. The crystals of the two different mutants diffracted X-rays beyond 2.0 Å resolution

  8. Spherical Torus Center Stack Design

    Energy Technology Data Exchange (ETDEWEB)

    C. Neumeyer; P. Heitzenroeder; C. Kessel; M. Ono; M. Peng; J. Schmidt; R. Woolley; I. Zatz

    2002-01-18

    The low aspect ratio spherical torus (ST) configuration requires that the center stack design be optimized within a limited available space, using materials within their established allowables. This paper presents center stack design methods developed by the National Spherical Torus Experiment (NSTX) Project Team during the initial design of NSTX, and more recently for studies of a possible next-step ST (NSST) device.

  9. Acoustic Center or Time Origin?

    DEFF Research Database (Denmark)

    Staffeldt, Henrik

    1999-01-01

    The paper discusses the acoustic center in relation to measurements of loudspeaker polar data. Also, it presents the related concept time origin and discusses the deviation that appears between positions of the acoustic center found by wavefront based and time based measuring methods....

  10. Stennis Space Center Virtual Tour

    Science.gov (United States)

    2009-01-01

    Have you ever wanted to visit Stennis Space Center? Or perhaps you have and you're ready to come back. Either way, you can visit Stennis Space Center from anywhere in world! Click on the video to begin your tour.

  11. Youth consultation and health centers

    Directory of Open Access Journals (Sweden)

    Şükrü

    2011-03-01

    Full Text Available In 2005, a youth consultation and health center has been established by cooperation of Turkish Ministry of Health, UNFPA and UNİCEF. Two doctors, 2 psychologists and 1 dietician is serving in our center. In this center, we serve for diagnosis and treatment of adolescents and when needed reference to other institutions. Consultation on physical-sexual development, psycho-social development, personal hygiene, nutrition, physical exercise, smoking and alcohol use, secure behaviors, secure sexual life and psychological problems is also given. Adolescents generally apply to the center for reasons like conflict with parents, low academic performance, aggression, being overweight, computer addiction, conflict with siblings and being short. As a result of our experience, we think that in order to develop adolescent health services, all health centers should be organized as “youth friendly”. (Turk Arch Ped 2011; 46 Suppl: 135-7

  12. Pengembangan Model Manajemen ICT Center

    Directory of Open Access Journals (Sweden)

    Hakkun Elmunsyah

    2013-01-01

    Full Text Available Abstrak: Pengembangan Model Manajemen ICT Center. Kemendiknas telah melakukan investasi  cukup besar berupa pembangunan Jejaring komputer pendidikan nasional yang disebut Jaringan Pendidikan Nasional (Jardiknas, pada sekolah menengah kejuruan (SMK di seluruh Indonesia yang dikenal dengan nama ICT center. Penelitian ini bertujuan untuk menemukan model manajemen ICT center sesuai karakteristik SMK sehingga dapat memberikan kontribusi mutu pada SMK tersebut. Penelitian ini merupakan penelitian pengembangan atau Research and Development yang dikembangkan oleh Borg and Gall. Hasil secara keseluruhan penelitian menunjukkan berdasarkan uji coba keefektivan kinerja manajemen pada skala terbatas dan lebih luas menunjukkan bahwa model manajemen ICT center memenuhi kriteria sangat efektif. Kata-kata kunci: Jardiknas, SMK, model manajemen ICT center, kontribusi mutu

  13. The study of ctx B and rstR variations of toxigenic Vibrio cholerae O1 E1 Tor strains isolated from 1961 to 2010 in China

    Institute of Scientific and Technical Information of China (English)

    梁未丽

    2014-01-01

    Objective To understand the ctx B and rstR variations of toxigenic Vibrio cholerae(V.cholerae)O1 E1 Tor strains isolated from different provinces in China from1961 to 2010.Methods All 385 toxigenic V.cholerae O1 E1 Tor strains were selected,which were isolated in China between year 1961 and 2010.ctx B gene was amplified by PCR method and sequenced for further analysis.rstR was detected with PCR by using the genotype

  14. Analysis of Cl center dot center dot center dot Cl and C-H center dot center dot center dot Cl intermolecular interactions involving chlorine in substituted 2-chloroquinoline derivatives

    OpenAIRE

    Hathwar, Venkatesha R.; Roopan, Mohana S; R. Subashini; Khan, Nawaz F; Row, Guru TN

    2010-01-01

    Six crystal structures of substituted 2-chloroquinoline derivatives have been analysed to evaluate the role of Cl atom as a self recognizing unit resulting in the formation of Cl center dot center dot center dot Cl and C-H center dot center dot center dot Cl interactions to generate supramolecular assembly in the solid state. The features of Type I and Type II geometries associated with Cl center dot center dot center dot Cl interactions have been analysed to show directional preferences lead...

  15. MIT Space Engineering Research Center

    Science.gov (United States)

    Crawley, Edward F.; Miller, David W.

    1990-01-01

    The Space Engineering Research Center (SERC) at MIT, started in Jul. 1988, has completed two years of research. The Center is approaching the operational phase of its first testbed, is midway through the construction of a second testbed, and is in the design phase of a third. We presently have seven participating faculty, four participating staff members, ten graduate students, and numerous undergraduates. This report reviews the testbed programs, individual graduate research, other SERC activities not funded by the Center, interaction with non-MIT organizations, and SERC milestones. Published papers made possible by SERC funding are included at the end of the report.

  16. Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans.

    Directory of Open Access Journals (Sweden)

    Morten Dall

    Full Text Available In non-obese diabetic (NOD mice, diabetes incidence is reduced by a gluten-free diet. Gluten peptides, such as the compound gliadin, can cross the intestinal barrier and may directly affect pancreatic beta cells. We investigated the effects of enzymatically-digested gliadin in NOD mice, INS-1E cells and rat islets. Six injections of gliadin digest in 6-week-old NOD mice did not affect diabetes development, but increased weight gain (20% increase by day 100. In INS-1E cells, incubation with gliadin digest induced a dose-dependent increase in insulin secretion, up to 2.5-fold after 24 hours. A similar effect was observed in isolated rat islets (1.6-fold increase. In INS-1E cells, diazoxide reduced the stimulatory effect of gliadin digest. Additionally, gliadin digest was shown to decrease current through KATP-channels. A specific gliadin 33-mer had a similar effect, both on current and insulin secretion. Finally, INS-1E incubation with gliadin digest potentiated palmitate-induced insulin secretion by 13% compared to controls. Our data suggest that gliadin fragments may contribute to the beta-cell hyperactivity observed prior to the development of type 1 diabetes.

  17. Gliadin Fragments and a Specific Gliadin 33-mer Peptide Close KATP Channels and Induce Insulin Secretion in INS-1E Cells and Rat Islets of Langerhans

    DEFF Research Database (Denmark)

    Dall, Morten; Calloe, Kirstine; Haupt-Jorgensen, Martin;

    2013-01-01

    In non-obese diabetic (NOD) mice, diabetes incidence is reduced by a gluten-free diet. Gluten peptides, such as the compound gliadin, can cross the intestinal barrier and may directly affect pancreatic beta cells. We investigated the effects of enzymatically-digested gliadin in NOD mice, INS-1E...

  18. A program for calculation of the E1, E2, and M1 transition probabilities in odd-odd nuclei taking the Coriolis mixing into account

    International Nuclear Information System (INIS)

    The program makes it possible to calculate the E1, E2 and M1 reduced transition probabilities in odd-odd deformed nuclei. The mixed wave functions used result from a least-squares fit of energy levels (taking the Coriolis effect into account) to the experimental ones, performed with the modified ODDODDCORI subprogram. (orig./HSI)

  19. Limits on the presence of sulfur in the young SNRs LMC N132D and SMC 1E0102.2-7219

    International Nuclear Information System (INIS)

    A new area-spectroscopy search for sulfur as a tracer of the Si Group of elements in the ejecta of the young SNRs, LMC N132D and SMC 1E0102.2--7219, yields negative results for [S II]λλ6719, 6731 and [S III]λλ9064, 9532

  20. Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.

    Directory of Open Access Journals (Sweden)

    Gabor Szalai

    Full Text Available Most anti-angiogenic preeclampsia models in rodents utilized the overexpression of a truncated soluble fms-like tyrosine kinase-1 (sFlt-1 not expressed in any species. Other limitations of mouse preeclampsia models included stressful blood pressure measurements and the lack of postpartum monitoring. We aimed to 1 develop a mouse model of preeclampsia by administering the most abundant human placental sFlt-1 isoform (hsFlt-1-e15a in preeclampsia; 2 determine blood pressures in non-stressed conditions; and 3 develop a survival surgery that enables the collection of fetuses and placentas and postpartum (PP monitoring.Pregnancy status of CD-1 mice was evaluated with high-frequency ultrasound on gestational days (GD 6 and 7. Telemetry catheters were implanted in the carotid artery on GD7, and their positions were verified by ultrasound on GD13. Mice were injected through tail-vein with adenoviruses expressing hsFlt-1-e15a (n = 11 or green fluorescent protein (GFP; n = 9 on GD8/GD11. Placentas and pups were delivered by cesarean section on GD18 allowing PP monitoring. Urine samples were collected with cystocentesis on GD6/GD7, GD13, GD18, and PPD8, and albumin/creatinine ratios were determined. GFP and hsFlt-1-e15a expression profiles were determined by qRT-PCR. Aortic ring assays were performed to assess the effect of hsFlt-1-e15a on endothelia.Ultrasound predicted pregnancy on GD7 in 97% of cases. Cesarean section survival rate was 100%. Mean arterial blood pressure was higher in hsFlt-1-e15a-treated than in GFP-treated mice (∆MAP = 13.2 mmHg, p = 0.00107; GD18. Focal glomerular changes were found in hsFlt-1-e15a -treated mice, which had higher urine albumin/creatinine ratios than controls (109.3 ± 51.7 μg/mg vs. 19.3 ± 5.6 μg/mg, p = 4.4 x 10(-2; GD18. Aortic ring assays showed a 46% lesser microvessel outgrowth in hsFlt-1-e15a-treated than in GFP-treated mice (p = 1.2 x 10(-2. Placental and fetal weights did not differ between the groups

  1. Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform.

    Science.gov (United States)

    Gabitzsch, Elizabeth S; Balint-Junior, Joseph P; Xu, Younong; Balcaitis, Stephanie; Sanders-Beer, Brigitte; Karl, Julie; Weinhold, Kent J; Paessler, Slobodan; Jones, Frank R

    2012-11-26

    Anti-vector immunity mitigates immune responses induced by recombinant adenovirus vector vaccines, limiting their prime-boost capabilities. We have developed a novel gene delivery and expression platform (Ad5 [E1-, E2b-]) that induces immune responses despite pre-existing and/or developed concomitant Ad5 immunity. In the present study, we evaluated if this new Ad5 platform could overcome the adverse condition of pre-existing Ad5 immunity to induce effective immune responses in prime-boost immunization regimens against two different infectious diseases in the same animal. Ad5 immune rhesus macaques (RM) were immunized multiple times with the Ad5 [E1-, E2b-] platform expressing antigens from simian immunodeficiency virus (SIV). Immunized RM developed cell-mediated immunity against SIV antigens Gag, Pol, Nef and Env as well as antibody against Env. Vaccinated and vector control RMs were challenged intra-rectally with homologous SIVmac239. During a 7-week follow-up, there was perturbation of SIV load in some immunized RM. At 7 weeks post-challenge, eight immunized animals (53%) did not have detectable SIV, compared to two RM controls (13%) (Pvaccinated with the same Ad5 [E1-, E2b-] platform expressing H1N1 influenza hemagglutinin (HA). Thirty days post Ad5 [E1-, E2b-]-HA vaccination, significant levels of influenza neutralizing antibody were induced in all animals that increased after an Ad5 [E1-, E2b-]-HA homologous boost. These data demonstrate the versatility of this new vector platform to immunize against two separate disease targets in the same animal despite the presence of immunity against the delivery platform, permitting homologous repeat immunizations with an Ad5 gene delivery platform. PMID:23041546

  2. Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

    Energy Technology Data Exchange (ETDEWEB)

    Dahms, Sven O., E-mail: sdahms@fli-leibniz.de [Leibniz Institute for Age Research (FLI), Beutenbergstrasse 11, 07745 Jena (Germany); Mayer, Magnus C. [Freie Universität Berlin, Thielallee 63, 14195 Berlin (Germany); Miltenyi Biotec GmbH, Robert-Koch-Strasse 1, 17166 Teterow (Germany); Roeser, Dirk [Leibniz Institute for Age Research (FLI), Beutenbergstrasse 11, 07745 Jena (Germany); Multhaup, Gerd [McGill University Montreal, Montreal, Quebec H3G 1Y6 (Canada); Than, Manuel E., E-mail: sdahms@fli-leibniz.de [Leibniz Institute for Age Research (FLI), Beutenbergstrasse 11, 07745 Jena (Germany)

    2015-03-01

    Two X-ray structures of APLP1 E2 with and without a heparin dodecasaccharide are presented, revealing two distinct binding modes of the protein to heparan sulfate. The data provide a mechanistic explanation of how APP-like proteins bind to heparan sulfates and how they specifically recognize nonreducing structures of heparan sulfates. Beyond the pathology of Alzheimer’s disease, the members of the amyloid precursor protein (APP) family are essential for neuronal development and cell homeostasis in mammals. APP and its paralogues APP-like protein 1 (APLP1) and APP-like protein 2 (APLP2) contain the highly conserved heparan sulfate (HS) binding domain E2, which effects various (patho)physiological functions. Here, two crystal structures of the E2 domain of APLP1 are presented in the apo form and in complex with a heparin dodecasaccharide at 2.5 Å resolution. The apo structure of APLP1 E2 revealed an unfolded and hence flexible N-terminal helix αA. The (APLP1 E2){sub 2}–(heparin){sub 2} complex structure revealed two distinct binding modes, with APLP1 E2 explicitly recognizing the heparin terminus but also interacting with a continuous heparin chain. The latter only requires a certain register of the sugar moieties that fits to a positively charged surface patch and contributes to the general heparin-binding capability of APP-family proteins. Terminal binding of APLP1 E2 to heparin specifically involves a structure of the nonreducing end that is very similar to heparanase-processed HS chains. These data reveal a conserved mechanism for the binding of APP-family proteins to HS and imply a specific regulatory role of HS modifications in the biology of APP and APP-like proteins.

  3. Poison control center - emergency number

    Science.gov (United States)

    ... ANYWHERE IN THE UNITED STATES This national hotline number will let you talk to experts in poisoning. ... centers in the United States use this national number. You should call if you have any questions ...

  4. Poison control center - emergency number

    Science.gov (United States)

    For a POISON EMERGENCY call: 1-800-222-1222 ANYWHERE IN THE UNITED STATES This national hotline number will let you ... is a free and confidential service. All local poison control centers in the United States use this ...

  5. Ames research center publications, 1975

    Science.gov (United States)

    Sherwood, B. R. (Compiler)

    1977-01-01

    This bibliography cites 851 documents by Ames Research Center personnel and contractors which appeared in formal NASA publications, journals, books, patents, and contractor reports in 1975, or not included in previous annual bibliographies. An author index is provided.

  6. Human-Centered Design Capability

    Science.gov (United States)

    Fitts, David J.; Howard, Robert

    2009-01-01

    For NASA, human-centered design (HCD) seeks opportunities to mitigate the challenges of living and working in space in order to enhance human productivity and well-being. Direct design participation during the development stage is difficult, however, during project formulation, a HCD approach can lead to better more cost-effective products. HCD can also help a program enter the development stage with a clear vision for product acquisition. HCD tools for clarifying design intent are listed. To infuse HCD into the spaceflight lifecycle the Space and Life Sciences Directorate developed the Habitability Design Center. The Center has collaborated successfully with program and project design teams and with JSC's Engineering Directorate. This presentation discusses HCD capabilities and depicts the Center's design examples and capabilities.

  7. CENTER FOR CYBER SECURITY STUDIES

    Data.gov (United States)

    Federal Laboratory Consortium — The mission of the Center for Cyber Security Studies is to enhance the education of midshipmen in all areas of cyber warfare, to facilitate the sharing of expertise...

  8. Clean Energy Solutions Center Services

    Energy Technology Data Exchange (ETDEWEB)

    2016-03-01

    The Solutions Center offers no-cost expert policy assistance, webinars and training forums, clean energy policy reports, data, and tools provided in partnership with more than 35 leading international and regional clean energy organizations.

  9. Shopping Malls - ShoppingCenters

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Collected from a variety of sources both commercial and internal, this layer represents shopping center locations within Volusia County and is maintained by the...

  10. Center for Beam Physics, 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    The Center for Beam Physics is a multi-disciplinary research and development unit in the Accelerator and Fusion Research Division at Lawrence Berkeley Laboratory. At the heart of the Center`s mission is the fundamental quest for mechanisms of acceleration, radiation and focusing of energy. Dedicated to exploring the frontiers of the physics of (and with) particle and photon beams, its primary mission is to promote the science and technology of the production, manipulation, storage and control systems of charged particles and photons. The Center serves this mission via conceptual studies, theoretical and experimental research, design and development, institutional project involvement, external collaborations, association with industry and technology transfer. This roster provides a glimpse at the scientists, engineers, technical support, students, and administrative staff that make up this team and a flavor of their multifaceted activities during 1993.

  11. Records Center Program Billing System

    Data.gov (United States)

    National Archives and Records Administration — RCPBS supports the Records center programs (RCP) in producing invoices for the storage (NARS-5) and servicing of National Archives and Records Administration’s...

  12. Center for Creative Studies, Detroit

    Science.gov (United States)

    AIA Journal, 1976

    1976-01-01

    One of the ten buildings chosen to receive 1976 AIA honor awards, the arts center houses the departments of sculpture, painting, graphics, advertising art, photography, and industrial design. (Author/MLF)

  13. Aim to International Shipping Center

    Institute of Scientific and Technical Information of China (English)

    Hu Wenxiu

    2009-01-01

    @@ Since 1990s,various countries in the world have been focusing on the construction of the key ports,leading to a fiercer competition between ports.For example,in East Asia,South Korea and Japan are rivaling for the international shipping center in Northeast Asia.Taking Busan Port and Gwangyang Port as the central ports,South Korea is boosting the ports expansion plans,to construct a"logistic center in Northeast Asia".Meanwhile.Japan is projecting the optimizmg and integration of port resources,to regain the international shipping center in Asia.The central government of China made plans for constructing Shanghai Shipping Center as early in 1996.and after 13 years'construction,now Shanghai Port has the largest cargo throughput and the second largest container throughput in the world.

  14. CMS Innovation Center Model Participants

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Innovation Center develops new payment and service delivery models in accordance with the requirements of section 1115A of the Social Security Act....

  15. FEMA Disaster Recovery Centers - KML

    Data.gov (United States)

    Department of Homeland Security — This is a KML file for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  16. Italy INAF Analysis Center Report

    Science.gov (United States)

    Negusini, M.; Sarti, P.

    2013-01-01

    This report summarizes the activity of the Italian INAF VLBI Analysis Center. Our Analysis Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics. IRA runs the observatories of Medicina and Noto, where two 32-m VLBI AZ-EL telescopes are situated. This report contains the AC's VLBI data analysis activities and shortly outlines the investigations into the co-locations of space geodetic instruments.

  17. Centered Sublattice and its Application

    Institute of Scientific and Technical Information of China (English)

    宋振明; 徐扬; 等

    1993-01-01

    In this paper,the concept of the centered sublattice is introduceed for lattice theory and the dis-composition theorem of a lattice is given.Based on the centered sublattice,we give some new descriptions of a modular lattice,a distributive lattice,a complemented lattice and an relatively complemented lattice,etc.These new decriptions established now researching methods for lattice theory.

  18. Relativistic two-center continuum

    OpenAIRE

    Wietschorke, Karl-Heinz; Schlüter, Paul; Soff, Gerhard; Rumrich, Klaus; Greiner, Walter

    2006-01-01

    A method is presented to define unique continuum states for the two-center Dirac Hamiltonian. In the spherical limit these states become the familiar angular-momentum eigenstates of the radial Coulomb potential. The different states for a fixed total energy ‖E‖>m may be distinguished by considering the asymptotic spin-angular distribution of states with unique scattering phases. The first numerical solutions of the two-center Dirac equation for continuum states are presented.

  19. User-Centered Data Management

    CERN Document Server

    Catarci, Tiziana; Kimani, Stephen

    2010-01-01

    This lecture covers several core issues in user-centered data management, including how to design usable interfaces that suitably support database tasks, and relevant approaches to visual querying, information visualization, and visual data mining. Novel interaction paradigms, e.g., mobile and interfaces that go beyond the visual dimension, are also discussed. Table of Contents: Why User-Centered / The Early Days: Visual Query Systems / Beyond Querying / More Advanced Applications / Non-Visual Interfaces / Conclusions

  20. User-Centered Social Software

    OpenAIRE

    Lehel, Vanda

    2007-01-01

    Within the scope of this thesis, the concept of user-centered social software as an innovative approach for personal information management support in online social networks is developed. The basis for this concept is established by the characterization of different kinds of social software and the extension of personal information management to information exchange in online social contexts. The user-centered social software model encompasses services for the acquisition of relevant informat...

  1. Advanced Call Center Supporting WAP Access

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Traditional call centers can be accessed via speech only, and the call center based on web provides both data and speech access, but it needs a powerful terminal-computer. By analyzing traditional call centers and call centers based on web, this paper presents the framework of an advanced call center supporting WAP access. A typical service is also described in detail.

  2. A Shift from Teacher Centered to Learner Centered Approach

    Directory of Open Access Journals (Sweden)

    Jeanne Schreurs

    2014-06-01

    Full Text Available In the framework of the project Western Eastern Teachers' Education Network (WETEN funded by the Tempus program the network of university teachers were established to share expertise on effective teaching and learning in universities. This network for pedagogical innovation in higher education brought together the experts from EU to share good practice and new teaching methods with academic staff from two eastern countries, Moldova and Ukraine. The learner centered concept was analyzed and guidelines for creating learner centered courses were developed and piloted. The concepts and some experiences in course design were also implemented by trained teachers in the developed courses within the WETEN project.

  3. Finding Communities by Their Centers.

    Science.gov (United States)

    Chen, Yan; Zhao, Pei; Li, Ping; Zhang, Kai; Zhang, Jie

    2016-01-01

    Detecting communities or clusters in a real-world, networked system is of considerable interest in various fields such as sociology, biology, physics, engineering science, and interdisciplinary subjects, with significant efforts devoted in recent years. Many existing algorithms are only designed to identify the composition of communities, but not the structures. Whereas we believe that the local structures of communities can also shed important light on their detection. In this work, we develop a simple yet effective approach that simultaneously uncovers communities and their centers. The idea is based on the premise that organization of a community generally can be viewed as a high-density node surrounded by neighbors with lower densities, and community centers reside far apart from each other. We propose so-called "community centrality" to quantify likelihood of a node being the community centers in such a landscape, and then propagate multiple, significant center likelihood throughout the network via a diffusion process. Our approach is an efficient linear algorithm, and has demonstrated superior performance on a wide spectrum of synthetic and real world networks especially those with sparse connections amongst the community centers. PMID:27053090

  4. INIS National Center in Syria

    International Nuclear Information System (INIS)

    International Nuclear Information System (INIS) is the world's leading information system on the peaceful uses of nuclear science and technology and it is operated by the International Atomic Energy Agency (IAEA) in Vienna, Austria. An overview of INIS products, services, philosophy and operation is given. INIS hold a database containing over 2.5 million references increasing at approximately 85,000 references per year and a collection of full text non-conventional, or grey literature that would be hard to obtain elsewhere. In addition, the PC-based software for inputs preparation (WinFIBRE) is demonstrated. INIS national center in Syria is considered as a regional center for INIS inputs preparation. The center is responsible for selecting the relevant nuclear literature produced and published in Syria and preparing the national inputs and send them to INIS Secretariat to be included in the INIS database. The center also provides INIS services and products to users within Syria. Availability of INIS Database on CD-ROMs, which updated monthly, and the internet version, which updated weekly, and the NCL collections are also presented. Finally, translation activity of the center, such as INIS Booklet entitled Presenting INIS, and the INIS Thesaurus into Arabic were mentioned. This was an in-kind contribution from the Atomic Energy Commission of Syria to support the valuable work of the INIS and Nuclear Knowledge Management (NKM) section and will contribute significantly the dissemination of information among the researchers and scientists in the Arab Countries. (author)

  5. Finding Communities by Their Centers

    Science.gov (United States)

    Chen, Yan; Zhao, Pei; Li, Ping; Zhang, Kai; Zhang, Jie

    2016-04-01

    Detecting communities or clusters in a real-world, networked system is of considerable interest in various fields such as sociology, biology, physics, engineering science, and interdisciplinary subjects, with significant efforts devoted in recent years. Many existing algorithms are only designed to identify the composition of communities, but not the structures. Whereas we believe that the local structures of communities can also shed important light on their detection. In this work, we develop a simple yet effective approach that simultaneously uncovers communities and their centers. The idea is based on the premise that organization of a community generally can be viewed as a high-density node surrounded by neighbors with lower densities, and community centers reside far apart from each other. We propose so-called “community centrality” to quantify likelihood of a node being the community centers in such a landscape, and then propagate multiple, significant center likelihood throughout the network via a diffusion process. Our approach is an efficient linear algorithm, and has demonstrated superior performance on a wide spectrum of synthetic and real world networks especially those with sparse connections amongst the community centers.

  6. Preocupações parentais e coping numa amostra de pais de crianças entre 1 e 9 anos

    OpenAIRE

    Gomes, Cátia Alexandra Cordeiro

    2008-01-01

    Dissertação de Mestrado apresentada ao Instituto Superior de Psicologia Aplicada para obtenção de grau de Mestre na especialidade de Psicologia Clínica. Objectivo: Comparar as Preocupações e Estratégias de Coping dos pais de crianças, entre 1 e 9 anos, procurando-se verificar se existem diferenças significativas nestas variáveis, em função da idade das crianças. Método: Estudo observacional descritivo, de comparação entre grupos. Participaram 34 pais de crianças com 1 e 2 anos,...

  7. Determination of the flexoelectric coefficient (e1-e3) in nematic liquid crystal by using fully leaky optical-guided mode

    Science.gov (United States)

    Zheng, Guili; Zhang, Hui; Ye, Wenjiang; Zhang, Zhidong; Song, Hong-wei; Xuan, Li

    2016-02-01

    Fully leaky optical-guided mode was employed to determine the difference in the splay and bend flexoelectric coefficient (e1-e3) in negative nematic liquid crystal MS-N01300-000. The experimental curves of reflectivity versus internal angle (angle of incident light to the liquid crystal) were obtained when a laser beam passed through the hybrid-aligned nematic in-plane switching liquid crystal cell; the cell was embedded in pyramid-coupled waveguide with different alternating current (AC) and direct current (DC) voltages. The curves of the applied DC with voltage similar to that of AC shift to the left or the right. Experimental results were then compared with theoretical results derived from elastic continuum theory and multi-layer optical theory of liquid crystals. The approximate value of the flexoelectric coefficient (e1-e3) of MS-N01300-000 is 9.0 × 10-11 C/m.

  8. The Variable X-ray and Near-IR Behavior of the Particularly Anomaloux X-ray Pulsar 1E 1048.1-5937

    CERN Document Server

    Tam, Cindy R; Dib, Rim; Kaspi, Victoria M; Woods, Peter M; Bassa, Cees

    2007-01-01

    We present the results of X-ray and near-IR observations of the anomalous X-ray pulsar 1E 1048.1-5937, believed to be a magnetar. This AXP underwent a period of extreme variability during 2001-2004, but subsequently entered an extended and unexpected quiescence in 2004-2006, during which we monitored it with RXTE, CXO, and HST. Its timing properties were stable for >3 years throughout the quiescent period. 1E 1048.1-5937 again went into outburst in March 2007, which saw a factor of >7 total X-ray flux increase which was anti-correlated with a pulsed fraction decrease, and correlated with spectral hardening, among other effects. The near-IR counterpart also brightened following the 2007 event. We discuss our findings in the context of the magnetar and other models.

  9. How to Understand Transplant Center Statistics

    Science.gov (United States)

    ... Print this page How to understand transplant center statistics Because statistics can be hard to understand, we recommend you ... NMDP transplant centers How to understand transplant center statistics Because statistics can be hard to understand, we ...

  10. Center Innovation Fund: KSC CIF Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Each individual NASA Center has full discretion on the use of the funds and the Center Chief Technologists coordinates a competitive process at their Center for the...

  11. Sacred Groves: Three University Fine Art Centers

    Science.gov (United States)

    Architectural Forum, 1974

    1974-01-01

    The Power Center for the Performing Arts at the University of Michigan; The Center for the Arts at Wesleyan; and the Fine Arts Center at the Amherst campus of the University of Massachusetts -- are temples to the performing arts. (Arthor)

  12. IEEE Std 344-1987: IEEE recommended practice for seismic qualification of Class 1E equipment for nuclear power generating stations

    International Nuclear Information System (INIS)

    Recommended practices for establishing procedures that will yield data, which verify that the Class 1E equipment can meet its performance requirements during and following one safe shutdown earthquake (SSE) preceded by a number of operating basis earthquakes (OBE), are provided in this document. This recommended practice may be used to establish tests or analyses that will yield data to substantiate performance claims or to evaluate and verify performance of representative devices and assemblies as part of an overall qualification effort

  13. IEEE Std 344-1975: IEEE recommended practices for seismic qualification of Class 1E equipment for nuclear power generating stations

    International Nuclear Information System (INIS)

    These recommended practices provide direction for establishing procedures that will yield data which verify that the Class 1E equipment can meet its performance requirements during and following one SSE (safe shutdown earthquake) preceded by a number of OBEs (operating basis earthquakes). This document may be used by equipment manufactures to establish procedures that will yield data to substantiate performance claims or by equipment users to evaluate and verify performance of representative devices and assemblies as part of an overall qualification effort

  14. Center for Beam Physics, 1993

    International Nuclear Information System (INIS)

    The Center for Beam Physics is a multi-disciplinary research and development unit in the Accelerator and Fusion Research Division at Lawrence Berkeley Laboratory. At the heart of the Center's mission is the fundamental quest for mechanisms of acceleration, radiation and focusing of energy. Dedicated to exploring the frontiers of the physics of (and with) particle and photon beams, its primary mission is to promote the science and technology of the production, manipulation, storage and control systems of charged particles and photons. The Center serves this mission via conceptual studies, theoretical and experimental research, design and development, institutional project involvement, external collaborations, association with industry and technology transfer. This roster provides a glimpse at the scientists, engineers, technical support, students, and administrative staff that make up this team and a flavor of their multifaceted activities during 1993

  15. Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors

    Directory of Open Access Journals (Sweden)

    Hongwei Li, Jin Zhong Li, Debra D. Pittman, Andy Amalfitano, Gerald R. Hankins, Gregory A. Helm

    2006-01-01

    Full Text Available Osteogenic potentials of some recombinant human bone morphogenetic protein (BMP first-generation adenoviral vectors (ADhBMPs are significantly limited in immunocompetent animals. It is unclear what role expression of viral proteins and foreign proteins transduced by adenoviral vectors play in the host immune response and in ectopic bone formation. In this study two sets of experiments were designed and performed. First, rat BMP6 cDNA were amplified, sequenced, and recombined in first-generation adenoviral vector (ADrBMP6. A comparison of human and rat BMP6 adenoviral vectors demonstrated identical osteogenic activities in both immunodeficient and immunocompetent rats. Second, the activities of recombinant human BMP6 in E1- (ADhBMP6 and [E1-,E2b-] ( [E1-,E2b-]ADGFP&hBMP6, and [E1-,E2b-]ADhBMP6 adenoviral vectors were compared in both in vitro and in vivo models. Similar activities of these two generations of BMP adenoviral vectors were found in all models. These results indicate that the amount of viral gene expression and the source of the BMP cDNA are not major factors in the interruption of osteogenic potentials of recombinant BMP6 adenoviral vectors in immunocompetent animals.

  16. A ultra-sonografia do pâncreas é eficaz em diagnosticar o diabete melito tipo 1 e tipo 2?

    Directory of Open Access Journals (Sweden)

    Pimenta Walkyria de Paula

    2002-01-01

    Full Text Available Este trabalho foi realizado para verificar se a ultra-sonografia do pâncreas oferece dados auxiliares na classificação de diabéticos adultos dos tipos 1 e 2. O tamanho e a ecogenicidade do pâncreas foram determinados pela ultra-sonografia em 81 diabéticos, sendo 20 do tipo 1 e 61 do tipo 2 (53 obesos e oito não-obesos. Os pacientes tipo 2 obesos diferiram dos demais por apresentarem área total e diâmetro ântero-posterior do corpo do pâncreas significativamente maiores. Quanto à ecogenicidade pancreática, esta estava aumentada com maior freqüência nos diabéticos tipo 2 obesos que nos diabéticos tipo 1. Consideramos, assim, que a ultra-sonografia do pâncreas constitui metodologia auxiliar na classificação de diabéticos entre os tipo 1 e 2, sendo menos eficaz quando os últimos não são obesos.

  17. Boosting of synaptic potentials and spine Ca transients by the peptide toxin SNX-482 requires alpha-1E-encoded voltage-gated Ca channels.

    Directory of Open Access Journals (Sweden)

    Andrew J Giessel

    Full Text Available The majority of glutamatergic synapses formed onto principal neurons of the mammalian central nervous system are associated with dendritic spines. Spines are tiny protuberances that house the proteins that mediate the response of the postsynaptic cell to the presynaptic release of glutamate. Postsynaptic signals are regulated by an ion channel signaling cascade that is active in individual dendritic spines and involves voltage-gated calcium (Ca channels, small conductance (SK-type Ca-activated potassium channels, and NMDA-type glutamate receptors. Pharmacological studies using the toxin SNX-482 indicated that the voltage-gated Ca channels that signal within spines to open SK channels belong to the class Ca(V2.3, which is encoded by the Alpha-1E pore-forming subunit. In order to specifically test this conclusion, we examined the effects of SNX-482 on synaptic signals in acute hippocampal slices from knock-out mice lacking the Alpha-1E gene. We find that in these mice, application of SNX-482 has no effect on glutamate-uncaging evoked synaptic potentials and Ca influx, indicating that that SNX-482 indeed acts via the Alpha-1E-encoded Ca(V2.3 channel.

  18. Caracterização de herpesvírus bovinos tipos 1 (BHV-1 e 5 (BHV-5 com anticorpos monoclonais

    Directory of Open Access Journals (Sweden)

    Souza V.F.

    2002-01-01

    Full Text Available O perfil antigênico de 45 herpesvírus (44 de bovinos, sendo seis amostras de referência de BHV-1 e 15 prováveis BHV-1; três amostras de referência de BHV-5 e 20 prováveis BHV-5 e uma amostra de herpesvírus bubalino (BuHV foi examinado com um painel de anticorpos monoclonais (Acms produzidos contra antígenos de herpesvírus bovinos. Para os exames, foi utilizada a prova de imunoperoxidase (IPX sobre cultivos de células infectadas, tendo os Acms como anticorpos primários. A determinação dos padrões de reatividade das amostras de vírus frente aos Acms permitiu a diferenciação entre os tipos 1 e 5. Todas as amostras isoladas de casos de encefalite apresentaram perfil de BHV-5. Quatro amostras de BHV-5 isoladas de áreas geograficamente distintas apresentaram perfís de reatividade diferenciados em relação às demais amostras do tipo 5. Duas amostras de vírus com perfil antigênico de BHV-5 foram isoladas de sêmen de animais infectados. Estes resultados comprovam a utilidade da caracterização antigênica com este painel de Acms na tipagem de amostras de BHV-1 e BHV-5.

  19. 78 FR 14549 - National Contact Center; Information Collection; National Contact Center Customer Evaluation Survey

    Science.gov (United States)

    2013-03-06

    ... ADMINISTRATION National Contact Center; Information Collection; National Contact Center Customer Evaluation... requirement regarding the National Contact Center customer evaluation surveys. In this request, the previously... compare its customer service levels to those of private industry contact centers. DATES: Submit...

  20. Self-Access Centers: Maximizing Learners’ Access to Center Resources

    Directory of Open Access Journals (Sweden)

    Mark W. Tanner

    2010-09-01

    Full Text Available Originally published in TESL-EJ March 2009, Volume 12, Number 4 (http://tesl-ej.org/ej48/a2.html. Reprinted with permission from the authors.Although some students have discovered how to use self-access centers effectively, the majority appear to be unaware of available resources. A website and database of materials were created to help students locate materials and use the Self-Access Study Center (SASC at Brigham Young University’s English Language Center (ELC more effectively. Students took two surveys regarding their use of the SASC. The first survey was given before the website and database were made available. A second survey was administered 12 weeks after students had been introduced to the resource. An analysis of the data shows that students tend to use SASC resources more autonomously as a result of having a web-based database. The survey results suggest that SAC managers can encourage more autonomous use of center materials by provided a website and database to help students find appropriate materials to use to learn English.

  1. Balancing Act: Student-Centered and Subject-Centered Instruction.

    Science.gov (United States)

    Schurr, Sandra

    1996-01-01

    Argues that the middle school philosophy must address physical, psychological, intellectual, social, moral, and ethical needs of young adolescents. Presents 10 different methods of instruction that teachers can utilize to meet students' needs in order to make learning more productive and to balance student-centered and subject-centered…

  2. Color centers in optic fibers

    International Nuclear Information System (INIS)

    Full text: Short-living and stationary color centers are studied in optic fibers (OF) with concentration of OH 1000 ppm at the temperatures of 77-300 K. As it was demonstrated in [1] concentration of OH of 1000 ppm in the optic fibers at room temperature does not observed. The studies showed that under irradiation at 77 K the color centers are formed with the absorption bands at 215, 260, 330 and 550 nm. In this work the idea was proposed that under irradiation with 105 Rad non-bridge oxygen atoms is not formed. This is supported by the researches showing that the band 215 nm, which is formed by E - centers, disappears at two values of temperature. The first E - centers disappear at 77 K, whereas the second one at 310 K. Here, the first E - center can be observed at 470-500 nm. Based on the stated above we assume that the values of OH concentration at 1000 ppm in optic fibers are not correct. It is obtained that at low temperatures of 77 - 300 K new phenomena are observed, i.e. existence of two E - color with peaks at 215 nm. The values of temperature at which these centers exist are different, the first exist at temperature up to 85 K, and the second one up to 300 K. (author) Reference: 1. V.B. Gavrilov, A.I. Golutvan, Yu.S. Gershtein et al. Absorption spectra in pure quartz optic fibers gamma-irradiated with 60Co source. // Instrumentation and techniques of experiment.- 1997.- No 4.- p. 23-32.

  3. Center Innovation Fund: JPL CIF Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Funds are distributed to each NASA Center to support emerging technologies and creative initiatives that leverage Center talent and capabilities. NASA scientists...

  4. Telework centers as local development

    OpenAIRE

    Lorentzen, Anne

    2013-01-01

    This paper discusses the establishment of distant work centers as an element in local development strategies in rural areas with a particular view on two new telework centers in Region North DenmarkDistant work is a phenomenon on the rise, due to the development of the internet on the one hand and new flexible work functions on the other hand. Not only the exchange of documents, but also meetings can be organized virtually by still better video conference equipment and programs. An implicatio...

  5. User-centered agile method

    CERN Document Server

    Deuff, Dominique

    2013-01-01

    Agile development methods began to emerge around 20 years ago. However, it was not until the early 2000s that they began to be widely used in industry. This growth was often due to the advent of Internet services requiring faster cycles of development in order to heighten the rate at which an ever-greater number of functionalities were made available. In parallel, user-centered design (UCD) methods were also becoming more and more widely used: hence, user-centered design and agile methods were bound to cross paths, at least in the telecoms industry! During this period, in the field of telec

  6. Telework centers as local development

    DEFF Research Database (Denmark)

    Lorentzen, Anne

    2013-01-01

    regardless of location, as long as there is access to internet. Not only firms, but individual labor is potentially liberated from the logic of physical location and proximity. Technically speaking ‘geography is dead’ and the clustering of new service jobs in big cities is no longer a technical necessity......This paper discusses the establishment of distant work centers as an element in local development strategies in rural areas with a particular view on two new telework centers in Region North Denmark Distant work is a phenomenon on the rise, due to the development of the internet on the one hand and...

  7. PACS strategy for imaging centers.

    Science.gov (United States)

    Bedel, Victoria; Zdanowicz, Mark

    2004-01-01

    Picture archiving and communications systems (PACS) have been available in imaging centers for many years, but they often were less functional, were not well integrated into patient information systems, and lacked the network backbone to implement a system. As modalities are replaced and technology improves, the ability and time for an imaging center to acquire, integrate, and utilize PACS has arrived. However, each imaging center must determine why it should invest in PACS. A business plan is the fundamental need. Each imaging center must understand its target market, growth rate, and staffing plans. Additional considerations lie in current and future modality availability, the need for offsite delivery of images and reports, and the potential need for remote transmission of images. These issues must be identified and prioritized. A multidisciplinary team is essential. The most successful PACS implementation begins with complete involvement from all levels. The team should be comprised of people with complementary skills who are committed to a common purpose, set of performance goals, and approach for which they hold themselves mutually accountable. The team must jointly decide on the project's objectives. These objectives fall under 4 categories: clinical, service, financial, and performance. PACS must be considered a tool to help accomplish each objective. The imaging center must determine its top priorities, then translate them into a technology "wish list." The center can then list those pieces of technology that are most important and prioritize them. There are even more considerations for connecting multiple imaging centers. The team must create a comprehensive request for proposal (RFP) and determine the vendors that will receive the document. Once the RFP responses have been received and the vendor has been selected, an effective training plan must be executed. Training plans should be competency-based, ensuring comfort and competency among all staff. Upon

  8. The Aube Center evaluation 2002

    International Nuclear Information System (INIS)

    During the meeting of the information local commission, organized the 7 may 2003, the ANDRA took stock on the Aube Center activities during the year 2002. These activities presented in the document concern: the stability of the wastes packages, the personnel safety, the environmental survey, the authorizations of releases, the public information, some data on the exploitation the environment and the radiation protection and a presentation of the storage Center of Morvilliers devoted to the storage of low activity wastes. (A.L.B.)

  9. Kempinski Hotel Beijing Lufthansa Center

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A shining star on the eastern part of Beijing Kempinski Hotel Beijing Lufthansa Center is located at the heart of the city, a fully integrated business complex with serviced apartments, top-class offices and showrooms. The hotel offers unrivaled conference, business and leisure facilities ideal for business travelers and leisure guests alike. Its impressive blend of grand Chinese cul-

  10. WellnessCenter clubs fitness

    OpenAIRE

    Torrescasana Carnicé, Roser

    2009-01-01

    Amb aquest projecte és pretén dinamitzar els clubs esportius del tipus fitness. WellnessCenter simula un conjunt de clubs esportius que pertanyen a la mateixa xarxa i per tant es troben tots publicats a la mateixa web encara que cadascun d'ells tingui el seu propi espai.

  11. Philippine Heart Center: the specialist

    International Nuclear Information System (INIS)

    The Philippine Heart Center introduced the use of computer technology to further improve management services to their patients. In the Nuclear Medicine Department, the gamma camera system interfaced with computers and the cardiac catheterization laboratory's X-ray angio system was used in diagnostic procedures not only the heart but also on the different vital organs of the body. 3 photos

  12. School-Based Health Centers

    Science.gov (United States)

    ... in school increase high school graduation rates decrease school discipline cases Studies show that teens, who might resist going to a doctor, are more willing to get help for problems like depression and weight issues at a school-based health center. This might be because they ...

  13. VMware vCenter cookbook

    CERN Document Server

    Kuminsky, Konstantin

    2015-01-01

    If you are a system administrator who has some experience with virtualization and already uses VMware vCenter, but wishes to learn more, then this is the book for you. If you are looking for tips or shortcuts for common administration tasks as well as workarounds for pain points in vSphere administration, you'll find this guide useful.

  14. Directions in Center Director Training

    Science.gov (United States)

    Bloom, Paula Jorde; Vinci, Yasmina; Rafanello, Donna; Donohue, Chip

    2011-01-01

    Exchange invited some of the leading trend watchers in the arena of director training to share their insights on the current state and future directions in this country. This article presents the authors' insights on the directions in center director training. They also share their views on whether the amount of and quality of training out there…

  15. Annual report 2007 Aube center

    International Nuclear Information System (INIS)

    The National Agency for the Radioactive Wastes Management (ANDRA), is public company, with an industrial and commercial status. This document presents the activities of the year 2007 for the Aube center. It details the installations, the safety and radiation protection policy, the main events of the tear, the radioactive wastes management and the public information mission. (A.L.B.)

  16. Budgeting for School Media Centers.

    Science.gov (United States)

    Drott, M. Carl

    1978-01-01

    Describes various forms of budgets and discusses concepts in budgeting useful to supervisors of school media centers: line item budgets, capital budgets, creating budgets, the budget calendar, innovations, PPBS (Planning, Programing, Budgeting System), zero-based budgeting, cost-benefit analysis, benefits, benefit guidelines, and budgeting for the…

  17. Equine Medical Center director honored

    OpenAIRE

    Douglas, Jeffrey S.

    2004-01-01

    Nathaniel White, of Hamilton, Va., the Jean Ellen Shehan Professor and Director of the Marion duPont Scott Equine Medical Center in Leesburg, was awarded the American Association of Equine Practitioners' "Distinguished Service Award" during its recent annual meeting in Denver.

  18. Writing Centers in 2020--Gone!

    Science.gov (United States)

    Bateman, Thomas L.

    Technology brought the writing center to life because of the word processor, but new technology is actually going to create robotic life that thinks with us, for us, to us. It will offer portability all from a microchip stored in a coat pocket. Technology will continue to expedite today's hurry up world, and this will carry over into the writer's…

  19. Compton-backscattered annihilation radiation from the Galactic Center region

    Science.gov (United States)

    Smith, D. M.; Lin, R. P.; Feffer, P.; Slassi, S.; Hurley, K.; Matteson, J.; Bowman, H. B.; Pelling, R. M.; Briggs, M.; Gruber, D.

    1993-01-01

    On 1989 May 22, the High Energy X-ray and Gamma-ray Observatory for Nuclear Emissions, a balloon-borne high-resolution germanium spectrometer with an 18-deg FOV, observed the Galactic Center (GC) from 25 to 2500 keV. The GC photon spectrum is obtained from the count spectrum by a model-independent method which accounts for the effects of passive material in the instrument and scattering in the atmosphere. Besides a positron annihilation line with a flux of (10.0 +/- 2.4) x 10 exp -4 photons/sq cm s and a full width at half-maximum (FWHM) of (2.9 + 1.0, -1.1) keV, the spectrum shows a peak centered at (163.7 +/- 3.4) keV with a flux of (1.55 +/- 0.47) x 10 exp -3 photons/sq cm s and a FWHM of (24.4 +/- 9.2) keV. The energy range 450-507 keV shows no positronium continuum associated with the annihilation line, with a 2-sigma upper limit of 0.90 on the positronium fraction. The 164 keV feature is interpreted as Compton backscatter of broadened and redshifted annihilation radiation, possibly from the source 1E 1740.7-2942.

  20. Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associated cholera toxin B subunit.

    Science.gov (United States)

    Rhie, Gi-eun; Jung, Hae-Mi; Kim, Bong Su; Mekalanos, John J

    2008-10-01

    Because of its production and use in Vietnam, the most widely used oral cholera vaccine consists of heat- or formalin-killed Vibrio cholerae whole cells (WC). An earlier version of this type of vaccine called whole cell-recombinant B subunit vaccine (BS-WC) produced in Sweden also contained the B subunit of cholera toxin (CTB). Both WC and BS-WC vaccines produced moderate levels of protection in field trials designed to evaluate their cholera efficacy. V. cholerae cells in these vaccines induce antibacterial immunity, and CTB contributes to the vaccine's efficacy presumably by stimulating production of anti-toxin neutralizing antibody. Although more effective than the WC vaccine, the BS-WC vaccine has not been adopted for manufacture by developing world countries primarily because the CTB component is difficult to manufacture and include in the vaccine in the doses needed to induce significant immune responses. We reasoned this was a technical problem that might be solved by engineering strains of V. cholerae that express cell-associated CTB that would co-purify with the bacterial cell fraction during the manufacture of WC vaccine. Here we report that construction of a V. cholerae O1 classical strain, O395-N1-E1, that has been engineered to accumulate CTB in the periplasmic fraction by disrupting the epsE gene of type II secretion pathway. O395-N1-E1 induces anti-CTB IgG and vibriocidal antibodies in mice immunized with two doses of formalin killed whole cells. Intraperitoneal immunization of mice with O395-N1-E1 induced a significantly higher anti-CTB antibody response compared to that of the parental strain, O395-N1. Our results suggest that this prototype cholera vaccine candidate strain may assist in preparing improved and inexpensive oral BS-WC cholera vaccine without the need to purify CTB separately. PMID:18582519

  1. Advanced Call Center Supporting WAP Access

    Institute of Scientific and Technical Information of China (English)

    YUANXiao-hua; CHENJun-liang

    2001-01-01

    Traditional call centers can be accessed via speech only, and the call center based on web provides both da-ta and speech access,but it needs a powerful terminal-computer.By analyzing traditional call centers and call cen-ters based on web, this paper presents the framework of an advanced call center supporting WAP access.A typical service is also described in detail.

  2. Prediction of the Adaptability of Pseudomonas putida DOT-T1E to a Second Phase of a Solvent for Economically Sound Two-Phase Biotransformations

    OpenAIRE

    Neumann, Grit; Kabelitz, Nadja; Zehnsdorf, Andreas; Miltner, Anja; Lippold, Holger; Meyer, Daniel; Schmid, Andreas; Heipieper, Hermann J

    2005-01-01

    The strain Pseudomonas putida DOT-T1E was tested for its ability to tolerate second phases of different alkanols for their use as solvents in two-liquid-phase biotransformations. Although 1-decanol showed an about 10-fold higher toxicity to the cells than 1-octanol, the cells were able to adapt completely to 1-decanol only and could not be adapted in order to grow stably in the presence of a second phase of 1-octanol. The main explanation for this observation can be seen in the higher water a...

  3. Fission cross section measurements of Cm-247, Cf-250 and Es-254 from 0.1 eV to 80 keV

    International Nuclear Information System (INIS)

    Fission cross section measurements were made with the RINS system over the neutron energy range from approximately 0.1 eV to 80 keV upon samples of Cm-247, Cf-250 and Es-254. The Cm-247 measurement was undertaken to complete the RINS fission cross section measurement sequence of the curium isotopes, Es-254 was measured because it is a very heavy odd-odd nucleus which might show interesting nuclear structure effects in its fission cross section, and Cf-250 was measured to account for its buildup as a daughter product from the 276-day halflife Es-254. 6 refs., 3 figs

  4. Full-Length Human Placental sFlt-1-e15a Isoform Induces Distinct Maternal Phenotypes of Preeclampsia in Mice

    OpenAIRE

    Gabor Szalai; Roberto Romero; Tinnakorn Chaiworapongsa; Yi Xu; Bing Wang; Hyunyoung Ahn; Zhonghui Xu; Po Jen Chiang; Birgitta Sundell; Rona Wang; Yang Jiang; Olesya Plazyo; Mary Olive; Adi L Tarca; Zhong Dong

    2015-01-01

    Objective Most anti-angiogenic preeclampsia models in rodents utilized the overexpression of a truncated soluble fms-like tyrosine kinase-1 (sFlt-1) not expressed in any species. Other limitations of mouse preeclampsia models included stressful blood pressure measurements and the lack of postpartum monitoring. We aimed to 1) develop a mouse model of preeclampsia by administering the most abundant human placental sFlt-1 isoform (hsFlt-1-e15a) in preeclampsia; 2) determine blood pressures in no...

  5. Chandra X-ray Observatory Arcsecond Imaging of the Young, Oxygen-rich Supernova Remnant 1E0102.2-7219

    OpenAIRE

    Gaetz, T. J.; Butt, Yousaf M.; Edgar, Richard J.; Eriksen, Kristoffer A.; Plucinsky, Paul P.; Schlegel, Eric M.; Smith, Randall K.

    2000-01-01

    We present observations of the young, Oxygen-rich supernova remnant 1E0102.2-7219 taken by the Chandra X-ray Observatory during Chandra's Orbital Activation and Checkout phase. The boundary of the blast wave shock is clearly seen for the first time, allowing the diameter of the remnant and the mean blast wave velocity to be determined accurately. The prominent X-ray bright ring of material may be the result of the reverse shock encountering ejecta; the radial variation of O VII vs. O VIII emi...

  6. Jellyfish: Networking Data Centers Randomly

    CERN Document Server

    Singla, Ankit; Popa, Lucian; Godfrey, P Brighten

    2011-01-01

    Industry experience indicates that the ability to incrementally expand data centers is essential. However, existing high-bandwidth network designs have rigid structure that interferes with incremental expansion. We present Jellyfish, a high-capacity network interconnect, which, by adopting a random graph topology, yields itself naturally to incremental expansion. Somewhat surprisingly, Jellyfish is more cost-efficient than a fat-tree: A Jellyfish interconnect built using the same equipment as a fat-tree, supports as many as 25% more servers at full capacity at the scale of a few thousand nodes, and this advantage improves with scale. Jellyfish also allows great flexibility in building networks with different degrees of oversubscription. However, Jellyfish's unstructured design brings new challenges in routing, physical layout, and wiring. We describe and evaluate approaches that resolve these challenges effectively, indicating that Jellyfish could be deployed in today's data centers.

  7. The Fermilab Particle Astrophysics Center

    Energy Technology Data Exchange (ETDEWEB)

    2004-11-01

    The Particle Astrophysics Center was established in fall of 2004. Fermilab director Michael S. Witherell has named Fermilab cosmologist Edward ''Rocky'' Kolb as its first director. The Center will function as an intellectual focus for particle astrophysics at Fermilab, bringing together the Theoretical and Experimental Astrophysics Groups. It also encompasses existing astrophysics projects, including the Sloan Digital Sky Survey, the Cryogenic Dark Matter Search, and the Pierre Auger Cosmic Ray Observatory, as well as proposed projects, including the SuperNova Acceleration Probe to study dark energy as part of the Joint Dark Energy Mission, and the ground-based Dark Energy Survey aimed at measuring the dark energy equation of state.

  8. Fuzzy Logic Reliability Centered Maintenance

    Directory of Open Access Journals (Sweden)

    Felecia .

    2014-01-01

    Full Text Available Reliability Centered Maintenence (RCM is a systematic maintenence strategy based on system reliability. Application of RCM process will not always come out with a binary output of “yes” and “no”. Most of the time they are not supported with available detail information to calculate system reliability. The fuzzy logic method attempts to eliminate the uncertainty by providing “truth” in different degrees.Data and responses from maintenance department will be processed using the two methods (reliability centered maintenance and fuzzy logic to design maintenance strategy for the company. The results of the fuzzy logic RCM application are maintenance strategy which fit with current and future condition.

  9. Rolex learning center English guide

    CERN Document Server

    Della Casa, Francesco

    2012-01-01

    The novel architectural form of this building, conceived of by the architects of SAANA (winners of the Pritzker Prize in 2010), compelled the building engineers to come up with unprecedented structural, technical and logistical solutions. And yet, once the Rolex Learning Center was complete, the ingenuity required for its construction had become practically invisible in the eyes of the uninitiated. This richly illustrated guide provides, in condensed form, an account of the extraordinary adventure of the realization of the Rolex Learning Center. It explains in detail the context of its construction and brings to light the spatial subtleties of its architecture. In addition, it provides the visitor of the building with all the needed technical information and many novel facts and figures.

  10. Land Center for Human Rights

    OpenAIRE

    Saber, Karam

    2013-01-01

    Why Land Center for Human Rights? The farmers’ issue represents a new and very important dimension for the Human Rights movement in Egypt for several reasons. The inadequacy of a legislative structure to protect agrarian laborers. In consequence, they are exposed to daily violations. The main targeted categories are women, children and permanent or seasonal agrarian laborers. The widening gap between urban and rural Egypt, especially in the services. Thus, a wide category of people are expose...

  11. Human Centered Design for Development

    OpenAIRE

    Knoche, Hendrik; Rao, Sheshagiri, P. R.; Huang, Jeffrey

    2011-01-01

    This paper describes the challenges faced in ICTD by reviewing the lessons learned from a project geared at improving the livelihood of marginal farmers in India through wireless sensor networks. Insufficient user participation, lack of attention to user needs, and a primary focus on technology in the design process led to unconvinced target users who were not interested in the new technology. The authors discuss benefits that ICTD can reap from incorporating human-centered design (HCD) princ...

  12. Learning System Center App Controller

    CERN Document Server

    Naeem, Nasir

    2015-01-01

    This book is intended for IT professionals working with Hyper-V, Azure cloud, VMM, and private cloud technologies who are looking for a quick way to get up and running with System Center 2012 R2 App Controller. To get the most out of this book, you should be familiar with Microsoft Hyper-V technology. Knowledge of Virtual Machine Manager is helpful but not mandatory.

  13. Clean Energy Solutions Center (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Reategui, S.

    2012-07-01

    The Clean Energy Ministerial launched the Clean Energy Solutions Center in April, 2011 for major economy countries, led by Australia and U.S. with other CEM partners. Partnership with UN-Energy is extending scope to support all developing countries: 1. Enhance resources on policies relating to energy access, small to medium enterprises (SMEs), and financing programs; 2. Offer expert policy assistance to all countries; 3. Expand peer to peer learning, training, and deployment and policy data for developing countries.

  14. Housing Booms and City Centers

    OpenAIRE

    Edward L. Glaeser; Joshua D. Gottlieb; Kristina Tobio

    2012-01-01

    Popular discussions often treat the great housing boom of the 1996-2006 period as if it were a national phenomenon with similar impacts across locales, but across metropolitan areas, price growth was dramatically higher in warmer, less educated cities with less initial density and higher initial housing values. Within metropolitan areas, price growth was faster in neighborhoods closer to the city center. The centralization of price growth during the boom was particularly dramatic in those met...

  15. Fuzzy Logic Reliability Centered Maintenance

    OpenAIRE

    , Felecia

    2014-01-01

    Reliability Centered Maintenence (RCM) is a systematic maintenence strategy based on system reliability. Application of RCM process will not always come out with a binary output of “yes” and “no”. Most of the time they are not supported with available detail information to calculate system reliability. The fuzzy logic method attempts to eliminate the uncertainty by providing “truth” in different degrees.Data and responses from maintenance department will be processed using the two methods (re...

  16. Northeast Regional Planetary Data Center

    Science.gov (United States)

    Schultz, Peter H.; Saunders, Stephen (Technical Monitor)

    2005-01-01

    In 1980, the Northeast Planetary Data Center (NEPDC) was established with Tim Mutch as its Director. The Center was originally located in the Sciences Library due to space limitations but moved to the Lincoln Field Building in 1983 where it could serve the Planetary Group and outside visitors more effectively. In 1984 Dr. Peter Schultz moved to Brown University and became its Director after serving in a similar capacity at the Lunar and Planetary Institute since 1976. Debbie Glavin has served as the Data Center Coordinator since 1982. Initially the NEPDC was build around Tim Mutch's research collection of Lunar Orbiter and Mariner 9 images with only partial sets of Apollo and Viking materials. Its collection was broadened and deepened as the Director (PHS) searched for materials to fill in gaps. Two important acquisitions included the transfer of a Viking collection from a previous PI in Tucson and the donation of surplused lunar materials (Apollo) from the USGS/Menlo Park prior to its building being torn down. Later additions included the pipeline of distributed materials such as the Viking photomosaic series and certain Magellan products. Not all materials sent to Brown, however, found their way to the Data Center, e.g., Voyager prints and negatives. In addition to the NEPDC, the planetary research collection is separately maintained in conjunction with past and ongoing mission activities. These materials (e.g., Viking, Magellan, Galileo, MGS mission products) are housed elsewhere and maintained independently from the NEPDC. They are unavailable to other researchers, educators, and general public. Consequently, the NEPDC represents the only generally accessible reference collection for use by researchers, students, faculty, educators, and general public in the Northeast corridor.

  17. New model of cultural center

    OpenAIRE

    Klimenta, Vojtěch

    2010-01-01

    Culture and Art have, without a doubt, always been major development factors for people and the society as a whole. However, there is no effortless access for everyone or everywhere. This Thesis is focused on the phenomenon of the multifunctional cultural center as an institution developing and initiating cultural and communal life in a region or in a smaller regional city with no cultural infrastructure or background. The first part deals with the discursus of the contemporary cultural cente...

  18. Expeditionary mobile operations center (EMOC)

    OpenAIRE

    Gonzalez, Jose

    2014-01-01

    This research explores a viable solution to the U.S.Marine Corps’ (USMC) communications gap at the tactical edge. The aim is to leverage commercial-off-the-shelf (COTS) technology to provide a combat operations center (COC) like communication architecture to small units operating in austere environments. The proposed architecture required must be lightweight, energy efficient, and allow greater mobility through a reduced footprint and energy consumption. By reducing the energy required for un...

  19. The Scientific Data Management Center

    OpenAIRE

    Shoshani, Arie

    2006-01-01

    With the increasing volume and complexity of data produced by ultra-scale simulations and high-throughput experiments, understanding the science is largely hampered by the lack of comprehensive, end-to-end data management solutions ranging from initial data acquisition to final analysis and visualization. The Scientific Data Management (SDM) Center is bringing a set of advanced data management technologies to DOE scientists in various application domains including astrophysics, climate, ...

  20. Hydrogen Bonds Involving Metal Centers

    OpenAIRE

    Pavlović, G.; N. Raos

    2006-01-01

    Hydrogen bonds involving metal center as a hydrogen donor or hydrogen acceptor are only a specific type of metal-hydrogen interactions; it is therefore not easy to differentiate hydrogen bond from other metal-hydrogen interactions, especially agostic ones. The first part of the review is therefore devoted to the results of structural chemistry and molecular spectroscopy (NMR, IR), as a tool for differentiating hydrogen bondings from other hydrogen interactions. The classical examples of Pt···...

  1. Structural Properties and Biological Prediction of ({[(1E-3-(1H-Imidazol-1-yl-1-phenylpropylidene] amino}oxy(4-methylphenylmethanone: An In Silico Approach

    Directory of Open Access Journals (Sweden)

    Maha S. Almutairi

    2015-12-01

    Full Text Available Bioactive molecules are playing essential role in the field of drug discovery and various pharmaceutical applications. Vibrational spectral investigations of the anti-Candida agent ({[(1E-3-(1H-imidazol-1-yl-1-phenylpropylidene]amino}oxy(4-methylphenylmethanone ((1E-IPMM have been recorded and analyzed to understand its structural geometry, inter- and intra-molecular interactions. The equilibrium geometry, harmonic vibrational wavenumber, natural bond orbital (NBO and Frontier orbital energy analyses have been carried out with the help of density functional theory with B3LYP/6-311++G(d,p level of theory. The detailed vibrational assignments for the title molecule were performed on the basis of potential energy distribution analysis in order to unambiguously predict its modes. The calculated wavenumbers had good agreement with the experimental values. NBO analysis has confirmed the intramolecular charge transfer interactions. The predicted docking binding energy gave insight into the possible biological activity of the title molecule.

  2. Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells

    Directory of Open Access Journals (Sweden)

    Jonathan Barlow

    2015-04-01

    Full Text Available High glucose and fatty acid levels impair pancreatic beta cell function. We have recently shown that palmitate-induced loss of INS-1E insulinoma cells is related to increased reactive oxygen species (ROS production as both toxic effects are prevented by palmitoleate. Here we show that palmitate-induced ROS are mostly mitochondrial: oxidation of MitoSOX, a mitochondria-targeted superoxide probe, is increased by palmitate, whilst oxidation of the equivalent non-targeted probe is unaffected. Moreover, mitochondrial respiratory inhibition with antimycin A stimulates palmitate-induced MitoSOX oxidation. We also show that palmitate does not change the level of mitochondrial uncoupling protein-2 (UCP2 and that UCP2 knockdown does not affect palmitate-induced MitoSOX oxidation. Palmitoleate does not influence MitoSOX oxidation in INS-1E cells ±UCP2 and largely prevents the palmitate-induced effects. Importantly, UCP2 knockdown amplifies the preventive effect of palmitoleate on palmitate-induced ROS. Consistently, viability effects of palmitate and palmitoleate are similar between cells ±UCP2, but UCP2 knockdown significantly augments the palmitoleate protection against palmitate-induced cell loss at high glucose. We conclude that UCP2 neither mediates palmitate-induced mitochondrial ROS generation and the associated cell loss, nor protects against these deleterious effects. Instead, UCP2 dampens palmitoleate protection against palmitate toxicity.

  3. The Energy Dependence of the Aperiodic Variability for Cygnus X-1, GX 339-4, GRS 1758-258, & 1E 1740.7-2942

    CERN Document Server

    Lin, D; Böttcher, M; Liang, E P

    1999-01-01

    Using the data from the Rossi X-ray Timing Explorer (RXTE), we report the different energy dependence of the variability of the four persistent hard X-ray sources in the low-hard state: Cygnus X-1, GX 339-4, GRS 1758-258 and 1E 1740.7-2942. Cygnus X-1 is found to have a flatter power density spectrum (PDS) shape at higher energies. The other three sources have energy independent PDS shapes. The energy dependence of the overall variability (the integrated rms amplitude) varies from source to source and from observation to observation. 1E~1740.7-2942, for example, has a variability generally increasing with energy while GX 339-4 has a decreasing variability. A general trend is found in the four sources that the integrated rms amplitude anti-correlates with the X-ray flux. We compare these distinct energy dependent behaviors with several emission models. None of the models can fully explain all the features that we have found.

  4. Measurement of the neutron capture cross section of the s-only isotope 204Pb from 1 eV to 440 keV

    CERN Document Server

    Domingo-Pardo, C; Aerts, G; Alvarez-Pol, H; Alvarez-Velarde, F; Andriamonje, S; Andrzejewski, J; Assimakopoulos, P; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calvino, F; Cano-Ott, D; Capote, R; Carrapico, C; Cennini, P; Chepel, V; Chiaveri, E; Colonna, N; Cortes, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillmann, I; Dolfini, R; Dridi, W; Duran, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Koelbl, H; Fujii, K; Furman, W; Gallino, R; Goncalves, I; Gonzalez-Romero, E; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martinez, A; Igashira, M; Isaev, S; Jericha, E; Kadi, Y; Kappeler, F; Karamanis, D; Karadimos, D; Kerveno, M; Ketlerov, V; Koehler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Mastinu, P; Mengoni, A; Milazzo, P.M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, H; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, C; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stephan, C; Tagliente, G; Tain, J.L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarin, D; Vincente, M.C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2007-01-01

    The neutron capture cross section of 204Pb has been measured at the CERN n_TOF installation with high resolution in the energy range from 1 eV to 440 keV. An R-matrix analysis of the resolved resonance region, between 1 eV and 100 keV, was carried out using the SAMMY code. In the interval between 100 keV and 440 keV we report the average capture cross section. The background in the entire neutron energy range could be reliably determined from the measurement of a 208Pb sample. Other systematic effects in this measurement could be investigated and precisely corrected by means of detailed Monte Carlo simulations. We obtain a Maxwellian average capture cross section for 204Pb at kT=30 keV of 79(3) mb, in agreement with previous experiments. However our cross section at kT=5 keV is about 35% larger than the values reported so far. The implications of the new cross section for the s-process abundance contributions in the Pb/Bi region are discussed.

  5. Requirements for a GaAsBi 1 eV sub-cell in a GaAs-based multi-junction solar cell

    International Nuclear Information System (INIS)

    Multi-junction solar cells achieve high efficiency by stacking sub-cells of different bandgaps (typically GaInP/GaAs/Ge) resulting in efficiencies in excess of 40%. The efficiency can be improved by introducing a 1 eV absorber into the stack, either replacing Ge in a triple-junction configuration or on top of Ge in a quad-junction configuration. GaAs0.94Bi0.06 yields a direct-gap at 1 eV with only 0.7% strain on GaAs and the feasibility of the material has been demonstrated from GaAsBi photodetector devices. The relatively high absorption coefficient of GaAsBi suggests sufficient current can be generated to match the sub-cell photocurrent from the other sub-cells of a standard multi-junction solar cell. However, minority carrier transport and background doping levels place constraints on both p/n and p-i-n diode configurations. In the possible case of short minority carrier diffusion lengths we recommend the use of a p-i-n diode, and predict the material parameters that are necessary to achieve high efficiencies in a GaInP/GaAs/GaAsBi/Ge quad-junction cell. (paper)

  6. Near-infrared Observations of Magnetars: XTE J1810-197, 1RXS J1708-4009, 1E 1841-045 and SGR 1900+14

    CERN Document Server

    Testa, V; Mignani, R P; Israel, G L; Perna, R; Chaty, S; Stella, L; Covino, S; Turolla, R; Zane, S; Curto, G Lo; Campana, S; Marconi, G; Mereghetti, S

    2007-01-01

    . We report on near-infrared (IR) observations of the three anomalous X-ray pulsars XTE J1810-197, 1RXS J1708-4009, 1E 1841-045 and the soft gamma-ray repeater SGR 1900+14, taken with the ESO-VLT, the Gemini, and the CFHT telescopes. . This work is aimed at identifying and/or confirming the IR counterparts of these magnetars, as well as at measuring their possible IR variability. . In order to perform photometry of objects as faint as Ks~20, we have used data taken with the largest telescopes, equipped with the most advanced IR detectors and in most of the cases with Adaptive Optics devices. The latter are critical to achieve the sharp spatial accuracy required to pinpoint faint objects in crowded fields. . We confirm with high confidence the identification of the IR counterpart to XTE J1810-197, and its IR variability. For 1E 1841-045 and SGR 1900+14 we propose two candidate IR counterparts based on the detection of IR variability. For 1RXS J1708-4009 we show that none of the potential counterparts within th...

  7. Isolation of 1E4 IgM Anti-Fasciola hepatica Rediae Monoclonal Antibody from Ascites: Comparison of Two Purification Protocols.

    Science.gov (United States)

    Alba, Annia; Marcet, Ricardo; Otero, Oscar; Hernández, Hilda M; Figueredo, Mabel; Sarracent, Jorge

    2016-02-01

    Purification of immunoglobulin M (IgM) antibodies could be challenging, and is often characterized by the optimization of the purification protocol to best suit the particular features of the molecule. Here, two different schemes were compared to purify, from ascites, the 1E4 IgM monoclonal antibody (mAb) previously raised against the stage of redia of the trematode Fasciola hepatica. This immunoglobulin is used as capture antibody in an immunoenzymatic assay to detect parasite ongoing infection in its intermediate hosts. The first purification protocol of the 1E4 mAb involved two chromatographic steps: an affinity chromatography on a Concanavalin A matrix followed by size exclusion chromatography. An immunoaffinity chromatography was selected as the second protocol for one-step purification of the antibody using the crude extract of adult parasites coupled to a commercial matrix. Immunoreactivity of the fractions during purification schemes was assessed by indirect immunoenzymatic assays against the crude extract of F. hepatica rediae, while purity was estimated by protein electrophoresis. Losses on the recovery of the antibody isolated by the first purification protocol occurred due to protein precipitation during the concentration of the sample and to low resolution of the size exclusion molecular chromatography step regarding this particular immunoglobulin. The immunoaffinity chromatography using F. hepatica antigens as ligands proved to be the most suitable protocol yielding a pure and immunoreactive antibody. The purification protocols used are discussed regarding efficiency and difficulties. PMID:26828226

  8. The potential of metabolomic analysis techniques for the characterisation of α1-adrenergic receptors in cultured N1E-115 mouse neuroblastoma cells.

    Science.gov (United States)

    Wenner, Maria I; Maker, Garth L; Dawson, Linda F; Drummond, Peter D; Mullaney, Ian

    2016-08-01

    Several studies of neuropathic pain have linked abnormal adrenergic signalling to the development and maintenance of pain, although the mechanisms underlying this are not yet fully understood. Metabolomic analysis is a technique that can be used to give a snapshot of biochemical status, and can aid in the identification of the mechanisms behind pathological changes identified in cells, tissues and biological fluids. This study aimed to use gas chromatography-mass spectrometry-based metabolomic profiling in combination with reverse transcriptase-polymerase chain reaction and immunocytochemistry to identify functional α1-adrenergic receptors on cultured N1E-115 mouse neuroblastoma cells. The study was able to confirm the presence of mRNA for the α1D subtype, as well as protein expression of the α1-adrenergic receptor. Furthermore, metabolomic data revealed changes to the metabolite profile of cells when exposed to adrenergic pharmacological intervention. Agonist treatment with phenylephrine hydrochloride (10 µM) resulted in altered levels of several metabolites including myo-inositol, glucose, fructose, alanine, leucine, phenylalanine, valine, and n-acetylglutamic acid. Many of the changes observed in N1E-115 cells by agonist treatment were modulated by additional antagonist treatment (prazosin hydrochloride, 100 µM). A number of these changes reflected what is known about the biochemistry of α1-adrenergic receptor activation. This preliminary study therefore demonstrates the potential of metabolomic profiling to confirm the presence of functional receptors on cultured cells. PMID:26408527

  9. The Japanese science education centers.

    Science.gov (United States)

    Glass, B

    1966-10-14

    These six Japanese science education centers signify a sweeping reform of elementary and secondary school science teaching. They achieve their striking results because they are established on a permanent, local basis and are supported mainly by the local boards of education. They have avoided control by pedagogues and specialists in "education." Instead, they are operated by trained scientists and experienced school teachers who work together to devise programs specially suited to the needs of their teachers. With small and practicable steps, the teachers improve their understanding of methods which they can readily test in their own classrooms rooms and laboratories. The laboratory equipment in the science education centers is only slightly superior to that which the teachers have in their own schools, but superior enough to make them desire to improve their own facilities. Major facilities, such as x-ray machines, electron microscopes, telescopes (15-cm), and machine shops, as well as good working collections of minerals and fossils, and adequate greenhouses, permit the teachers to work with more expensive equipment, to gain a firsthand knowledge of its operation, and to bring groups of students to the center to observe what such instruments make possible. The use of American experimental course content improvement programs is widespread. Every science education center I visited is using PSSC, CHEMS, CBA, BSCS, or ESCP materials and studying the philosophy of these programs. Yet no center is entirely dependent on these programs, but uses them critically to supplement and improve its own courses. The emphasis is on good laboratory and field teaching as a basis for understanding scientific methods and concepts. Science as investigation and inquiry, instead of treatment solely as an authoritative body of facts, is coming into its own. The few defects of the science education centers of Japan inhere in the educational situation itself. The centers are at present

  10. Information on the Karlsruhe Nuclear Research Center

    International Nuclear Information System (INIS)

    A short overview is given about the origins of Karlsruhe Nuclear Research Center. The historical development of the different companies operating the Center is shown. Because the original task assigned to the Center was the construction and testing of the first German reactor exclusively built by German companies, a detailed description of this reactor and the changes made afterwards is presented. Next, today's organizational structure of the Center is outlined and the development of the Center's financing since its foundation is shown. A short overview about the structure of employees from the Center's beginning up to now is also included as well as a short description of today's main activities. (orig.)

  11. Influence of paramagnetic centers on the nuclear spin lattice relaxation in NQR experiments

    International Nuclear Information System (INIS)

    We investigated the influence of paramagnetic centers on the nuclear spin relaxation in NQR experiments. 35Cl NQR spectra, spin-lattice relaxation times in laboratory and rotating frames T1 and T1e and spin-spin relaxation time T2 in NaClO3 have been measured at 77 Κ. for a large range of PI concentration. Paramagnetic centers were developed by g-irradiation with doses of 0.2, 1, 3, 5, 10, 20 and 50 Mrad. Nonirradiated NaClO3 sample has been also studied. The amount and origin of PI were controlled by ESR measurements. NQR frequency and line width in nonirradiated sample at 77 Κ. were found to be 30.63245 MHz and 1.2 khz, respectively. Line width shows linear dependence on the dose of irradiation in the whole range of irradiation, while larger doses result in a deviation of line shift from the linear law. These frequency and line width variations result from the distortion of electric field gradient; a static broadening may be also caused by the dipole-dipole interaction between the unpaired magnetic moments of the paramagnetic centers and the magnetic moments of the resonant nuclei. The value of spin-spin relaxation time T2=0.8 ms does not vary with irradiation within the accuracy of the experiment. Spin-lattice relaxation time T1 Shows no visible changes up to 3 Mrad. By fitting the M(t) decay with a stretched exponent given by the expression Mo [1 - Bexp(-(t/T1 )α)], we found the parameter a around 0.83 [1]. However, further irradiation reduces both T1 and a. These changes are attributed to the influence of paramagnetic centers and may be explained in the frames of the theory of relaxation via paramagnetic centers in the absence of spin diffusion. Measurements of T1e show that magnetization decay is two-exponential for the delay between pulses > 50 ms and becomes close to one-exponential when reduce the delay s. Analysis of one-exponential decay with a stretched exponent shows visible dependence of T1e and a on the dose of irradiation which are attributed to

  12. The Northeast Climate Science Center

    Science.gov (United States)

    Ratnaswamy, M. J.; Palmer, R. N.; Morelli, T.; Staudinger, M.; Holland, A. R.

    2013-12-01

    The Department of Interior Northeast Climate Science Center (NE CSC) is part of a federal network of eight Climate Science Centers created to provide scientific information, tools, and techniques that managers and other parties interested in land, water, wildlife and cultural resources can use to anticipate, monitor, and adapt to climate change. Recognizing the critical threats, unique climate challenges, and expansive and diverse nature of the northeast region, the University of Massachusetts Amherst, College of Menominee Nation, Columbia University, Marine Biological Laboratory, University of Minnesota, University of Missouri Columbia, and University of Wisconsin-Madison have formed a consortium to host the NE CSC. This partnership with the U.S. Geological Survey climate science center network provides wide-reaching expertise, resources, and established professional collaborations in both climate science and natural and cultural resources management. This interdisciplinary approach is needed for successfully meeting the regional needs for climate impact assessment, adaptive management, education, and stakeholder outreach throughout the northeast region. Thus, the NE CSC conducts research, both through its general funds and its annual competitive award process, that responds to the needs of natural resource management partners that exist, in part or whole, within the NE CSC bounds. This domain includes the North Atlantic, Upper Midwest and Great Lakes, Eastern Tallgrass and Big Rivers, and Appalachian Landscape Conservation Cooperatives (LCCs), among other management stakeholders. For example, researchers are developing techniques to monitor tree range dynamics as affected by natural disturbances which can enable adaptation of projected climate impacts; conducting a Designing Sustainable Landscapes project to assess the capability of current and potential future landscapes in the Northeast to provide integral ecosystems and suitable habitat for a suite of

  13. Process Engineering Technology Center Initiative

    Science.gov (United States)

    Centeno, Martha A.

    2002-01-01

    NASA's Kennedy Space Center (KSC) is developing as a world-class Spaceport Technology Center (STC). From a process engineering (PE) perspective, the facilities used for flight hardware processing at KSC are NASA's premier factories. The products of these factories are safe, successful shuttle and expendable vehicle launches carrying state-of-the-art payloads. PE is devoted to process design, process management, and process improvement, rather than product design. PE also emphasizes the relationships of workers with systems and processes. Thus, it is difficult to speak of having a laboratory for PE at K.S.C. because the entire facility is practically a laboratory when observed from a macro level perspective. However, it becomes necessary, at times, to show and display how K.S.C. has benefited from PE and how K.S.C. has contributed to the development of PE; hence, it has been proposed that a Process Engineering Technology Center (PETC) be developed to offer a place with a centralized focus on PE projects, and a place where K.S.C.'s PE capabilities can be showcased, and a venue where new Process Engineering technologies can be investigated and tested. Graphics for showcasing PE capabilities have been designed, and two initial test beds for PE technology research have been identified. Specifically, one test bed will look into the use of wearable computers with head mounted displays to deliver work instructions; the other test bed will look into developing simulation models that can be assembled into one to create a hierarchical model.

  14. Kennedy Space Center Spaceport Analysis

    Science.gov (United States)

    Wary, Samantha A.

    2013-01-01

    Until the Shuttle Atlantis' final landing on July 21, 2011, Kennedy Space Center (KSC) served as NASA's main spaceport, which is a launch and landing facility for rockets and spacecraft that are attempting to enter orbit. Many of the facilities at KSC were created to assist the Shuttle Program. One of the most important and used facilities is the Shuttle Landing Facility (SLF), This was the main landing area for the return of the shuttle after her mission in space. · However, the SLF has also been used for a number of other projects including straight-line testing by Gibbs Racing, weather data collection by NOAA, and an airfield for the KSC helicopters. This runway is three miles long with control tower at midfield and a fire department located at the end in care of an emergency. This facility, which was part of the great space race, will continue to be used for historical events as Kennedy begins to commercialize its facilities. KSC continues to be an important spaceport to the government, and it will transform into an important spaceport for the commercial industry as well. During my internship at KSC's Center Planning and Development Directorate, I had the opportunity to be a part of the negotiation team working on the agreement for Space Florida to control the Shuttle Landing Facility. This gave me the opportunity to learn about all the changes that are occurring here at Kennedy Space Center. Through various meetings, I discovered the Master Plan and its focus is to transform the existing facilities that were primarily used for the Shuttle Program, to support government operations and commercial flights in the future. This. idea is also in a new strategic business plan and completion of a space industry market analysis. All of these different documentations were brought to my attention and I. saw how they came together in the discussions of transitioning the SLF to a commercial operator, Space Florida. After attending meetings and partaking in discussions for

  15. The MIT Stata Center dataset

    OpenAIRE

    Fallon, M; Johannsson, H.; Kaess, M.; Leonard, J. J.

    2013-01-01

    This paper presents a large scale dataset of vision (stereo and RGB-D), laser and proprioceptive data collected over an extended duration by a Willow Garage PR2 robot in the 10 story MIT Stata Center. As of September 2012 the dataset comprises over 2.3 TB, 38 h and 42 km (the length of a marathon). The dataset is of particular interest to robotics and computer vision researchers interested in long-term autonomy. It is expected to be useful in a variety of research areas—robotic mapping (long-...

  16. Materials Characterization Center program plan

    International Nuclear Information System (INIS)

    The Materials Characterization Center (MCC) has been established at Pacific Northwest Laboratory as part of the Materials Characterization Organization for providing an authoritative, referenceable basis for establishing nuclear waste material properties and test methods. The MCC will provide a data base that will include information on the components of the waste emplacement package - the spent fuel or processed waste form and the engineered barriers - and their interaction with each other and as affected by the environment. The MCC will plan materials testing, develop and document procedures, collect and analyze existing materials data, and conduct tests as necessary

  17. Air Risk Information Support Center

    Energy Technology Data Exchange (ETDEWEB)

    Shoaf, C.R.; Guth, D.J. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    The Air Risk Information Support Center (Air RISC) was initiated in early 1988 by the US Environmental Protection Agency`s (EPA) Office of Health and Environmental Assessment (OHEA) and the Office of Air Quality Planning and Standards (OAQPS) as a technology transfer effort that would focus on providing information to state and local environmental agencies and to EPA Regional Offices in the areas of health, risk, and exposure assessment for toxic air pollutants. Technical information is fostered and disseminated by Air RISCs three primary activities: (1) a {open_quotes}hotline{close_quotes}, (2) quick turn-around technical assistance projects, and (3) general technical guidance projects. 1 ref., 2 figs.

  18. Management of nuclear training center

    International Nuclear Information System (INIS)

    This report describes the annual results of training courses. The scope and contents are as follows : 1. Regional and interregional training courses, 2. Training courses assisted by foreign experts, 3. Training courses for nuclear industry personnel, 4. Training courses for internal staff-members, 5. Training courses under the law. The nuclear training center executed the open-door training courses for 2,699 engineers/scientists from the regulatory body, nuclear industries, research institutes and other related organizations by means of offering 69 training courses during the fiscal year 1995. (Author) .new

  19. Human-Centered Information Fusion

    CERN Document Server

    Hall, David L

    2010-01-01

    Information fusion refers to the merging of information from disparate sources with differing conceptual, contextual and typographical representations. Rather than focusing on traditional data fusion applications which have been mainly concerned with physical military targets, this unique resource explores new human-centered trends, such as locations, identity, and interactions of individuals and groups (social networks). Moreover, the book discusses two new major sources of information: human observations and web-based information.This cutting-edge volume presents a new view of multi-sensor d

  20. 核级差压变送器静压影响的分析%The analysis of static pressure effect on 1E differential pressure transmitters

    Institute of Scientific and Technical Information of China (English)

    王占元; 廖圣勇

    2013-01-01

      The instrument of nuclear power plant is an important device to ensure the safety and economic operation of nuclear power plants.For the nuclear power plant using instrumentation,especially 1E instrument have higher in terms of accuracy,stability or reliability is vital.According to the requirements of relevant safety standards,measurement and protection channel must calculate instrument channel accuracy to verify whether or not it can meet the designing requirement.There is special precision requirement for the transmitter accuracy in the whole accuracy channel.The error from the static pressure has many influences upon the transmitter accuracy calculation,and it may cause transmitters to miss the designing requirement.This paper mainly introduces the influencing factors of 1E functional accuracy calculations and the static pressure elimination method of 1E differential pressure transmitters.%  核电站仪表是保证核电站安全和经济运行的重要设备。对于核电站用仪表,尤其是核级仪表无论在精确度、稳定性还是可靠性等方面都有较高的要求。根据相关安全准则要求,测量保护通道必须计算仪表的通道精度来验证其是否满足设计要求。在整个通道精度中对变送器的精度有特殊要求。而变送器的静压产生的误差会严重影响通道精度计算,导致其无法满足设计要求。本文主要介绍核电站用核级变送器的功能精度影响因素及差压变送器静压影响消除方法。