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Sample records for cellulitis

  1. Cellulitis

    Science.gov (United States)

    ... insect bite. What are the complications of preseptal cellulitis? Infection can spread posteriorly into the orbit or other ... there is generally full recovery. What causes orbital cellulitis? Spread of infection is the most common cause of orbital cellulitis. ...

  2. Orbital cellulitis

    Science.gov (United States)

    ... hemolytic streptococci may also cause orbital cellulitis. Orbital cellulitis infections in children may get worse very quickly and ... in the space around the eye. An orbital cellulitis infection can get worse very quickly. A person with ...

  3. Preseptal Cellulitis, Orbital Cellulitis, Orbital Abscess

    OpenAIRE

    Rana Altan Yaycıoğlu

    2012-01-01

    Patients with orbital infections present to our clinic usually with unilateral pain, hyperemia, and edema of the eyelids. The differentiation between preseptal and orbital cellulitis is utmost important in that the second requires hospitalization. Since in orbital cellulitis, the tissues posterior to the orbital septum are involved, signs such as conjunctival chemosis, limited eye movement, decreased vision, as well as afferent pupil defect secondary to optic nerve involvement may al...

  4. Preseptal and orbital cellulitis

    OpenAIRE

    Emine Akçay; Gamze Dereli Can; Nurullah Çağıl

    2014-01-01

    Preseptal cellulitis (PC) is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC) is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites) or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epid...

  5. Is Cellulitis Contagious?

    Science.gov (United States)

    ... isn't usually spread from person to person. Cellulitis is an infection of the deeper layers of the skin most ... chills Swollen glands or lymph nodes Left untreated, cellulitis can rapidly ... soft tissue infections. In: Rosen's Emergency Medicine: Concepts and Clinical Practice. ...

  6. Tonsillar Cellulitis and Abscess

    Science.gov (United States)

    ... Vocal Cord Contact Ulcers Vocal Cord Paralysis Tonsillar cellulitis is a bacterial infection of the tissues around the tonsils. A tonsillar ... Laryngoceles Retropharyngeal Abscess Salivary Gland Disorders Submandibular ... and Tonsillar Abscess Tonsillopharyngitis Vocal Cord Polyps, Nodules, ...

  7. Preseptal Cellulitis, Orbital Cellulitis, Orbital Abscess

    Directory of Open Access Journals (Sweden)

    Rana Altan Yaycıoğlu

    2012-12-01

    Full Text Available Patients with orbital infections present to our clinic usually with unilateral pain, hyperemia, and edema of the eyelids. The differentiation between preseptal and orbital cellulitis is utmost important in that the second requires hospitalization. Since in orbital cellulitis, the tissues posterior to the orbital septum are involved, signs such as conjunctival chemosis, limited eye movement, decreased vision, as well as afferent pupil defect secondary to optic nerve involvement may also be observed. Prompt intravenous antibiotic treatment should be started, and surgical drainage may be performed if patient shows failure to improve in 48 hours despite optimal management. Without treatment, the clinical course may progress to subperiosteal or orbital abscess, and even to cavernous sinus thrombosis. (Turk J Ophthalmol 2012; 42: Supplement 52-6

  8. Necrobiosis lipoidica mimicking cellulitis

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    Joshi A

    1997-01-01

    Full Text Available A 57-year-old obese patient presented with a 5 month history of tender, indurated, erythematous plaques with superficial ulceration on the right shin. The lesions closely mimicked cellulitis but were unresponsive to antibiotics. Though the patient was not a known diabetic, on investigations she was found to be a diabetic. Histology confirmed the diagnosis of necrobiosis lipoidica. This acutely inflammed presentation of necrobiosis lipoidica is extremely rare.

  9. Eosinophilic cellulitis and dermographism.

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    Nguyen, Nathalie Q; Ma, Linglei

    2005-12-30

    A 26-year-old man presented with a history of intermittent erythematous plaques on his hands and legs. A peripheral blood eosinophilia was noted. Histopathologic examination showed numerous eosinophils and characteristic flame figures. The clinical presentation and histopathologic alterations are consistent with the diagnosis of Wells' syndrome, which is also known as eosinophilic cellulitis. Wells' syndrome is a rare condition of unclear etiology. We discuss its diagnosis and possible association with other conditions that manifest peripheral eosinophilia.

  10. Preseptal and orbital cellulitis

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    Emine Akçay

    2014-09-01

    Full Text Available Preseptal cellulitis (PC is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, Haempphilus influenzae, Moraxella catarrhalis and S. pyogenes. The method for the diagnosis of OS and PS is computed tomography. Using effective antibiotics is a mainstay for the treatment of PC and OC. There is an agreement that surgical drainage should be performed in cases of complete ophthalmoplegia or significant visual impairment or large abscesses formation. This infections are also at a greater risk of acute visual loss, cavernous sinus thrombosis, meningitis, cerebritis, endophthalmitis, and brain abscess in children. Early diagnosis and appropriate treatment are crucial to control the infection. Diagnosis, treatment, management and complications of PC and OC are summarized in this manuscript. J MicrobiolInfect Dis 2014; 4(3: 123-127

  11. Odontogenic Facial Cellulitis

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    Yordany Boza Mejias

    2012-11-01

    Full Text Available Background: odontogenic facial cellulitis is an acute inflammatory process manifested in very different ways, with a variable scale in clinical presentation ranging from harmless well defined processes, to diffuse and progressive that may develop complications leading the patient to a critical condition, even risking their lives. Objective: To characterize the behavior of odontogenic facial cellulitis. Methods: A descriptive case series study was conducted at the dental clinic of Aguada de Pasajeros, Cienfuegos, from September 2010 to March 2011. It included 56 patients who met the inclusion criteria. Variables analyzed included: sex, age, teeth and regions affected, causes of cellulite and prescribed treatment. Results: no sex predilection was observed, lower molars and submandibular anatomical region were the most affected (50% and 30 4% respectively being tooth decay the main cause for this condition (51, 7%. The opening access was not performed to all the patients in the emergency service. The causal tooth extraction was not commonly done early, according to the prescribed antibiotic group. Thermotherapy with warm fomentation and saline mouthwash was the most prescribed and the most widely used group of antibiotics was the penicillin. Conclusions: dental caries were the major cause of odontogenic cellulite. There are still difficulties with the implementation of opening access.

  12. Understanding pediatric bacterial preseptal and orbital cellulitis

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    Gonzalez Mithra

    2010-01-01

    Full Text Available Pediatric preseptal and orbital cellulitis are infectious disorders that result in periorbital inflammation. Preseptal cellulitis is often associated with breaches in the skin barrier whereas orbital cellulitis is commonly associated with paranasal sinusitis. Orbital cellulitis may be associated with subperiosteal abscess. It is important to distinguish between preseptal from orbital cellulitis. Clinical examination and diagnostic imaging are useful in determining appropriate management. Patients are usually treated with broad spectrum antibiotics and surgery when indicated.

  13. Recurrent Cellulitis: How Can I Prevent It?

    Science.gov (United States)

    ... M.D. To help prevent recurrent episodes of cellulitis — a bacterial infection in the deepest layer of skin — keep skin ... www.merckmanuals.com/professional/dermatologic_disorders/bacterial_skin_infections/cellulitis.html?qt=cellulitis&alt=sh. Accessed Dec. 20, ...

  14. [Cellulitis: clinical manifestations and management].

    Science.gov (United States)

    Blum, C-L; Menzinger, S; Genné, D

    2013-10-09

    Cellulitis is an acute bacterial non-necrotizing dermal-hypodermal infection predominantly affecting the lower limbs. It is characterised by a circumscribed erythema with a raised border and fever. The predisposing factors are skin wounds, edema from any cause and systemic factors (diabetes, immunosuppression). The diagnosis is clinical and the most common complication is recurrence. Other complications include local abscess, fasciitis and bacteremia. The germ is rarely identified. The majority of infections (85%) is due to group A beta-hemolytic streptococcus. The treatment of cellulitis consists of an association of an antibiotic with rest of the concerned area.

  15. Cellulitis: definition, etiology, and clinical features.

    Science.gov (United States)

    Gunderson, Craig G

    2011-12-01

    Cellulitis is a common condition seen by physicians. Over the past decade, skin and soft tissue infections from community-associated methicillin-resistant Staphylococcus aureus have become increasingly common. In this article, the definition, etiology, and clinical features of cellulitis are reviewed, and the importance of differentiating cellulitis from necrotizing soft tissue infections is emphasized. Empiric antimicrobial recommendations are suggested, including the most recent recommendations from the Infectious Disease Society of America.

  16. Cellulitis

    Science.gov (United States)

    ... system — such as diabetes, leukemia and HIV/AIDS — leave you more susceptible to infections. Certain medications, such as corticosteroids, also can weaken your immune system. Skin conditions. Skin disorders — such as eczema, athlete's ...

  17. Cellulitis

    Science.gov (United States)

    The health care provider will perform a physical exam. This may reveal: Redness, warmth, and swelling of the skin Possible drainage, if there is a buildup of pus ( abscess ) with the skin infection Swollen glands (lymph nodes) ...

  18. Cellulitis Due to Salmonella infantis.

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    Satish R Patil

    2013-01-01

    Full Text Available Bacteria of the genus Salmonella are highly adapted for the growth in both humans and animals and cause a wide spectrum of disease. The growth of Serotypes S. typhi and S. paratyphi is restricted to human hosts, in whom these organisms cause enteric (typhoid fever. The remaining Serotypes (non typhoidal Salmonella or NTS can colonize the gastrointestinal tracts of the broad range of animals, including mammals, reptiles, birds and insects. The usual clinical presentation of non-typhoidal salmonellae (NTS infection is self limited gastroenteritis; however bacteremia and focal extra intestinal infection may occur. However salmonella localization to the skin presenting as cutaneous ulceration is regarded as a rare event. Rates of morbidity and mortality associated with NTS are highest among the elderly, infants, and immunocompromised individuals, including those with hemoglobinopathies, HIV infection, or infections that cause blockade of the reticuloendothelial system. We isolated S.infantis in 50 years old man with left leg cellulitis. The serotype was confirmed at Central Research Institute, Kasauli.

  19. Mastoiditis mimicry: retro-auricular cellulitis related to otitis externa.

    Science.gov (United States)

    Block, Stan L

    2014-09-01

    Retro-auricular cellulitis associated with otitis externa is now the great mimicker of mastoiditis. It may be the most common cause of this specific cellulitis/auricular protrusion when it is associated with otitis externa. This column presents six cases of children who presented with peri-auricular redness, four of whom had protuberant ear and retro-auricular cellulitis.

  20. Diagnosis of Cellulitis in the Immunocompromised Host

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    Charles F Carey

    1990-01-01

    Full Text Available A prospective study of diagnostic techniques in cellulitis was performed on 28 patients with malignancy. Twenty-two (78% of the fine needle aspiration cultures and 10 (35% of the blood cultures were positive in this immunocompromised population. The incidence of positive fine needle aspiration cultures (P<0.005 or bacteremia (P<0.0005 was significantly higher than results obtained in an immunocompetent population with cellulitis at the same institution. Staphylococci or streptococci were recovered in 59% of positive cultures, while aerobic Gram-negative bacilli grew in 33%. This study indicates that in the immunocompromised population with cellulitis, fine needle aspiration and blood cultures should be obtained, and the antibiotic regimen should cover Gram-positive cocci and Gram-negative bacilli pending the results of cultures.

  1. Bullous leukemia cutis mimicking facial cellulitis*

    Science.gov (United States)

    Caldato, Luciana de Sales; Britto, Juliana de Sousa; Niero-Melo, Ligia; Miot, Hélio Amante

    2016-01-01

    Bullous leukemia cutis is an uncommon clinical manifestation of cutaneous infiltration by leukemic cells, from B-cell chronic lymphocytic leukemia. We present the case of a 67-year-old, female, chronic lymphocytic leukemia patient. She was taking chlorambucil and developed facial edema with erythema and warmth, misjudged as facial cellulitis. Two days later, she developed bullous lesions in the arms, legs, neck and face. The histopathology of facial and bullous lesions confirmed leukemia cutis. All lesions disappeared following the administration of rituximab combined with cycles of fludarabine and cyclophosphamide. Although soft tissue infections are common complications in patients undergoing chemotherapy, leukemia cutis can also resemble cellulitis. PMID:27192532

  2. Celulitis por citomegalovirus Cytomegalovirus cellulitis

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    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.Cutaneous lesions in CMV infection are rare, often a late manifestation of systemic infection, and usually herald a fatal course. A 70 year-old woman received a kidney transplantation one month before consulting and immunosuppressive therapy that included cyclosporine A and methylprednisone. She complained of fever, local pain in her right leg, and an erythematous and swelling plaque. She was treated with intravenous antibiotics without improvement. A skin biopsy was performed and the tissue obtained was sent for bacterial and fungal cultures as well as for histological examination. Cultures were negative. The biopsy showed CMV cytopathic changes. Immunoperoxidase staining was positive for CMV and polymerase chain reaction (PCR testing revealed CMV DNA. She was treated with ganciclovir with resolution of the lesion. CMV cellulitis is a rare cutaneous manifestation

  3. Group G Streptococcus bacteremia in recurrent cellulitis.

    Science.gov (United States)

    di Meo, Nicola; Stinco, Giuseppe; Gubertini, Nicoletta; Patriarca, Maria Martina; Trevisan, Giusto

    2014-01-01

    In recent years, group G Streptococcus has been reported with increasing frequency as the cause of a variety of human infections. Underlying host factors such as immunosuppression, malignancy, diabetes mellitus, and rheumatoid arthritis may be predisposing conditions leading to infection. Toxic involvement and post-streptococcal sequalae, once believed to be exclusive to infections caused by group A Streptococcus, are now known to occur following acute group G Streptococcus and group C Streptococcus infections. We report on a case of group G Streptococcus bacteremia and recurrent cellulitis with toxic involvement. Patient blood cultures were always negative for β-hemolytic Streptococci in all the recurrences, except during the last one. Antibiotic therapy based on antibiogram quickly resolved the infection. A regimen of intramuscular injection of 1.2 million units of benzathine penicillin every 15 days for one year prevented recurrences of cellulitis.

  4. Campylobacter jejuni cellulitis in a patient with pan-hypogammaglobulinaemia

    OpenAIRE

    Hopkins, S; Abuzakouk, M; Brannigan, E; Bergin, C; Feighery, C

    2011-01-01

    The case of a 17-year-old male with recurrent episodes of cellulitis affecting his left shin is presented. The cellulitis had been present on an intermittent basis over an 18-month period despite several courses of both intravenous and oral antibiotics. Each course of antibiotics resulted in a temporary remission, but on four occasions the cellulitis then relapsed. The patient was known to have pan-hypogammaglobulinaemia and was receiving intravenous IgG replacement therapy every 3 weeks. Oth...

  5. Il controllo epigenetico di geni oncosoppressori nelle cellule staminali neuronali normali e di medulloblastoma

    OpenAIRE

    Begalli, Federica

    2013-01-01

    Le cellule staminali cerebellari normali fanno parte della grande famiglia delle cellule staminali somatiche, deputate a sostituire le cellule che muoiono per omeostasi fisiologica del tessuto o per un danno. Tali cellule mantengono alcune delle caratteristiche versatili delle cellule staminali embrionali. In particolare sono dotate della capacità di auto-rinnovamento indefinito e di multipotenza, difatti sono in grado di differenziare in più linee cellulari. Le cellule staminali neuronali ...

  6. Cellulitis in a Red Kandhari Bull : A Case Report

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    M M Pathan

    2012-06-01

    Full Text Available A case of cellulitis caused by mixed infection of Staphylococcus spp. and Corynebacterium spp in a Red Kandhari bull leading to death of animal was autopsied at the department. It is being a case of cellulitis in a Red Kandhari bull and placed on record. [Vet. World 2012; 5(3.000: 183-184

  7. INCIDENCE AND CLINICAL FEATURES OF SNAKEBITE CELLULITIS AT KIMS, HUBLI

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    Chetan

    2014-12-01

    Full Text Available BACKGROUND: A single centre study was planned to asses the incidence and clinical feature of snake bite cellulitis in order to find out the nature and burden of the disease. OBJECTIVES: To assess incidence and clinical features of snake bite cellulitis. METHODOLOGY: This present one year prospective study was conducted in the Department of Surgery, Karnataka Institute of Medical Sciences, Hubli. Out of 520 total cases of snake bites 66 patients with cellulitis changes were studied. STATISTICAL ANALYSIS: The data obtained was coded and entered in Microsoft Excel Spreadsheet. The categorical data was expressed as rates, ratios and percentages. RESULTS: Out of 520 total snake bite cases, 66 patients developed signs of cellulitis. In patients with cellulitis 49(74.24% were males and 17(25.75% were females. In patients with cellulitis, most were aged between 31 to 45 years (36.36% and 19 to 30 years (34.84.The mean age of the study population was 32.43 ± 13.75 years. Majority of the patients (74.24% had snake bite on lower limbs. Most common symptom complex noted was pain + swelling in 30(39.39% of the patients followed by pain in 9(13.6%, swelling in 6(9%, pain+swelling+fever in 4(6%, pain + discolouration in 2(3% and pain + fever in 1(1.5% of the patients. CONCLUSIONS: The present study shows high incidence of cellulitis in patients with snake bite and most common clinical feature is cellulitis is pain + swelling. So in any case of snake of snake bite we should take the proper precautionary measures to prevent cellulitis. If cellulitis has already formed, then it should be treated without delay in order to prevent limb loss, compartment syndrome, other morbidities and even death.

  8. Cellules solaires photovoltaïques plastiques enjeux et perspectives

    Science.gov (United States)

    Sicot, L.; Dumarcher, V.; Raimond, P.; Rosilio, C.; Sentein, C.; Fiorini, C.

    2002-04-01

    Après avoir détaillé le fonctionnement d'une cellule photovoltaïque plastique et les paramètres photovoltaïques permettant de caractéiser son efficacité, un état de l'art des technologies de fabrication des cellules est présenté. Des moyens d'amélioration des performances des cellules photovoltaïques organiques sont ensuite illustrés par l'étude de dispositifs développés au Laboratoire Composants Organiques (LCO) du CEA Saclay.

  9. Orbital cellulitis following silicone-sponge scleral buckles

    OpenAIRE

    Nemet AY; Ferencz JR; Segal O; Meshi A

    2013-01-01

    Arie Y Nemet, Joseph R Ferencz, Ori Segal, Amit Meshi Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel Background: Acute or chronic infection of the scleral explant is rare. We report seven cases of scleral explant infections that caused orbital cellulitis. Materials and methods: This was a retrospective chart review of oculoplastics at oculoplastics and vitreo-retinal units in a secondary referral hospital. All subjects had orbital cellulitis secondary to scleral buckle i...

  10. Sweet's syndrome associated with cellulitis - a challenging diagnosis

    OpenAIRE

    Resende, Cristina; Santos, Rui; Pereira,Teresa; Brito,Celeste

    2016-01-01

    Abstract Sweet's syndrome is a neutrophilic dermatosis with worldwide distribution that has been associated with inflammatory autoimmune diseases, infections, malignancies, drugs, and pregnancy. The disease is idiopathic in up to 50% of patients. A 64-year-old woman, diagnosed with right limb cellulitis (4 days of evolution), was seen at our department, due to persistent cellulitis and progressive appearance of painful nodules and plaques in both shins and the right forearm (2 days of evoluti...

  11. Serratia marcescens: an unusual pathogen associated with snakebite cellulitis.

    Science.gov (United States)

    Subramani, Parimala; Narasimhamurthy, Gokul Bindiganavile; Ashokan, Bhaskaran; Madappa, Beena Prasavangada

    2013-02-15

    This study reports a case of Serratia marcescens cellulitis following a snakebite in a 50-year-old woman. The bite was on the dorsum of the right hand with symptoms of envenomation. She developed swelling and cellulitis with tissue necrosis. Wound debridement was performed.  Pus and tissue biopsy cultures yielded Serratia marcescens sensitive to fluoroquinolones, aminoglycosides, third-generation cephalosporins and carbapenems. The patient responded to anti-snake venom (ASV) therapy, ciprofloxacin, local wound management and recovered uneventfully.

  12. Bacillus cereus cellulitis from contaminated heroin.

    Science.gov (United States)

    Dancer, S J; McNair, D; Finn, P; Kolsto, A B

    2002-03-01

    Concern exists over recent unexplained deaths among intravenous drug users. This report describes a patient with crepitant cellulitis who was admitted complaining of severe pain in the right forearm. Ultrasonography demonstrated gas in the tissues and he was referred for early surgical debridement of the arm. He was treated with intravenous benzyl penicillin, gentamicin and metronidazole and made a full recovery. Aspirate samples grew Bacillus cereus, morphologically similar to the isolate obtained from a sample of the patient's own heroin. Antibiogram and API 50CHB profiles were also similar. Further typing included 'H' flagellar serotyping, which found both blood and heroin strains to be non-typable, and amplified fragment polymorphism analysis, which showed that the strains were indistinguishable. Genotyping of two selected genes from B. cereus confirmed almost certain identity between the two strains. This case illustrates the potential virulence of B. cereus when inoculated into tissues, and to our knowledge, is the first report to demonstrate a conclusive microbiological link between contaminated heroin and serious sepsis in a drug user due to B. cereus.

  13. Ambient Ozone and Emergency Department Visits for Cellulitis

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    Mieczysław Szyszkowicz

    2010-11-01

    Full Text Available Objectives were to assess and estimate an association between exposure to ground-level ozone and emergency department (ED visits for cellulitis. All ED visits for cellulitis in Edmonton, Canada, in the period April 1992–March 2002 (N = 69,547 were examined. Case-crossover design was applied to estimate odds ratio (OR, and 95% confidence interval per one interquartile range (IQR increase in ozone concentration (IQR = 14.0 ppb. Delay of ED visit relating to exposure was probed using 0- to 5-day exposure lags. For all patients in the all months (January–December and lags 0 to 2 days, OR = 1.05 (1.02, 1.07. For male patients during the cold months (October-March: OR = 1.05 (1.02, 1.09 for lags 0 and 2 and OR = 1.06 (1.02, 1.10 for lag 3. For female patients in the warm months (April-September: OR = 1.12 (1.06, 1.18 for lags 1 and 2. Cellulitis developing on uncovered (more exposed skin was analyzed separately, observed effects being stronger. Cellulitis may be associated with exposure to ambient ground level ozone; the exposure may facilitate cellulitis infection and aggravate acute symptoms.

  14. Caratteristiche biologiche e potenziale applicativo delle cellule staminali derivate da membrane fetali

    OpenAIRE

    Costa, Roberta

    2013-01-01

    La ricerca sulle cellule staminali apre nuove prospettive per approcci di terapia cellulare. Molta attenzione è concentrata sulle cellule staminali isolate da membrane fetali, per la facilità di recupero del materiale di partenza, le limitate implicazioni etiche e le caratteristiche delle popolazioni di cellule staminali residenti. In particolare a livello dell’epitelio amniotico si concentra una popolazione di cellule (hAECs) con interessanti caratteristiche di staminalità, pluripotenza e im...

  15. Is it necrotizing fasciitis or necrotizing cellulitis after varicella zoster infection? Two case reports.

    Science.gov (United States)

    Gundeslioglu, Ayse Ozlem; Selimoglu, Muhammed Nebil; Toy, Hatice

    2014-08-01

    Necrotizing fasciitis and necrotizing cellulitis are serious cutaneous complications in varicella patients. Differentiation of necrotizing cellulitis from necrotizing fasciitis can initially be challenging because of indistinct clinical course at the onset of infection and the lack of definitive diagnostic criteria. This paper reports 2 children with necrotizing cellulitis that developed after varicella infection to draw the attention of health care providers to necrotizing cellulitis that showed slower clinical course than necrotizing fasciitis and recovered with conservative treatment approaches without aggressive surgical intervention.

  16. Risk factors of cellulitis in cirrhosis and antibiotic prophylaxis in preventing recurrence

    OpenAIRE

    Hamza, Rooby Erachamveettil; Villyoth, Mashhood Padincharepurathu; Peter, George; Joseph, Deni; Govindaraju, Chethan; Tank, Devang Chandrakanth; Sreesh, Sreejaya; Narayanan, Premalatha; Vinayakumar, Kattoor Ramakrishnan

    2014-01-01

    Background Cellulitis is a commonly encountered bacterial infection among cirrhotic patients apart from spontaneous bacterial peritonitis, urinary tract and respiratory infections. This study aimed to determine the risk factors of cellulitis in cirrhosis and whether antibiotic prophylaxis helps prevent recurrence of cellulitis. Methods The study was conducted in two phases. In phase 1, all cirrhotic patients admitted with cellulitis from August 2011 to August 2013 were taken as cases (n=70) a...

  17. Retropharyngeal cellulitis complicated by cervical spondylodiscitis: A case report

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    Gülşen İskender

    2015-12-01

    Full Text Available Secondary to pharyngeal trauma such as endotracheal intubation, endoscopy and after foreign body ingestion, or removal may develop retropharyngeal cellulitis in adults. These infections occur mainly in children between 1 to 8 years of age with 75% of cases occurring before the age of 5 years. Retropharyngeal cellulitis is a serious deep space infection which can extend from neck to the mediastinum.Herein, we represent a case of 24-year-old female patient who presented with neck pain, odynophagia, and malaise two months after accidental ingestion of a little pin. Uncomplicated removal of this pin was followed by development of retropharyngeal cellulitis and cervical pondylodiscitis. The patient was successfully treated with intravenous and oral antibiotics for 12 weeks without need to surgical intervention.We believe that early and aggressive medical treatment can eradicate nonsuppurative complicated retropharyngeal infection without the need for surgery. J Microbiol Infect Dis 2015;5(4: 180-183

  18. Nonpigmented Chromobacterium violaceum bacteremic cellulitis after fish bite.

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    Yang, Ching-Huei

    2011-10-01

    A case of nonpigmented Chromobacterium violaceum bacteremic cellulitis after fish bite in Taiwan is reported. The patient was successfully treated with ciprofloxacin and doxycycline for an extended period. Chromobacterium violaceum should be listed in the differential diagnosis of patients with nonspecific cellulitis associated with marked leukocytosis and rapid progression to septicemia either with or without a distinct history of exposure to water or soil. A combination of prompt diagnosis, optimal antimicrobial therapy, and adequate therapeutic duration for C violaceum infection is the key for successful therapy.

  19. Genetic susceptibility to non-necrotizing erysipelas/cellulitis.

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    Katariina Hannula-Jouppi

    Full Text Available BACKGROUND: Bacterial non-necrotizing erysipelas and cellulitis are often recurring, diffusely spreading infections of the skin and subcutaneous tissues caused most commonly by streptococci. Host genetic factors influence infection susceptibility but no extensive studies on the genetic determinants of human erysipelas exist. METHODS: We performed genome-wide linkage with the 10,000 variant Human Mapping Array (HMA10K array on 52 Finnish families with multiple erysipelas cases followed by microsatellite fine mapping of suggestive linkage peaks. A scan with the HMA250K array was subsequently performed with a subset of cases and controls. RESULTS: Significant linkage was found at 9q34 (nonparametric multipoint linkage score (NPL(all 3.84, p=0.026, which is syntenic to a quantitative trait locus for susceptibility to group A streptococci infections on chromosome 2 in mouse. Sequencing of candidate genes in the 9q34 region did not conclusively associate any to erysipelas/cellulitis susceptibility. Suggestive linkage (NPL(all>3.0 was found at three loci: 3q22-24, 21q22, and 22q13. A subsequent denser genome scan with the HMA250K array supported the 3q22 locus, in which several SNPs in the promoter of AGTR1 (Angiotensin II receptor type I suggestively associated with erysipelas/cellulitis susceptibility. CONCLUSIONS: Specific host genetic factors may cause erysipelas/cellulitis susceptibility in humans.

  20. Serum Procalcitonin Level Reflects the Severity of Cellulitis

    Science.gov (United States)

    Noh, Soo Hyeon; Park, Seok Don

    2016-01-01

    Background Cellulitis is a common bacterial infection of the superficial skin. Procalcitonin is one of the precursor proteins of calcitonin, its levels are elevated in bacterial infection, and it has been established as a diagnostic marker for severe bacterial infections. Objective This study evaluated the clinical usefulness of procalcitonin for predicting disease severity and prognosis of cellulitis. Methods We reviewed the medical records of 160 patients diagnosed with cellulitis in the past 3 years. Body temperature, procalcitonin, white blood cell (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured on their first day of admission. The associations of procalcitonin, WBC, ESR, and CRP with the body temperature and the number of hospitalized days were assessed. Results Procalcitonin, WBC, and CRP showed a positive correlation with body temperature. In addition, procalcitonin, WBC, ESR, and CRP showed a positive correlation with number of hospitalized days (p<0.05). Conclusion In patients diagnosed with cellulitis, proclacitonin was a helpful parameter to indicate the severity of disease and also a useful predictor of prognosis. PMID:27904269

  1. Clinical Approach in Orbital Cellulitis Cases: Case Series

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    Altan Atakan Özcan

    2012-07-01

    Full Text Available Pur po se: To evaluate the etiological factors, diagnosis, follow-up and treatment procedures in cases of orbital cellulitis. Ma te ri al and Met hod: A retrospective review was performed on medical records of patients with orbital cellulitis treated between 2009 and 2011 in our clinic. The patients were studied for age, ophthalmologic examination features, laboratory and radiology results, treatment modalities and the response to these treatments. Re sults: Eleven patients (7 male, 4 female having an average age of 9.7 years (6 months-25 years participated in the study. All patients had eyelid oedema, hyperemia and ocular pain; with chemosis in 3, gaze restriction in 6, relative afferent pupillary defect and proptosis in 4 cases. Orbital cellulitis was observed to occur secondary to paranasal sinusitis in 10 patients (90.9% and 1 patient had only history of superior respiratory tract infection. Sinus infection was localized in ethmoid and maxillary sinuses in all except one case. Laboratory tests showed leukocytosis in 8 patients. Surgical drainage was performed in 7 of 8 patients with abscess formation observed with radiological imaging. The remainder of the patients were followed with sole medical treatment. All patients recovered without any vision loss or life-threatening complication. Dis cus si on: Orbital cellulitis cases must be followed with radiologic imaging for any complication that may occur and patients with abscess should be evaluated for surgical drainage besides antimicrobial treatment.(Turk J Ophthalmol 2012; 42: 284-7

  2. Orbital cellulitis following silicone-sponge scleral buckles

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    Nemet AY

    2013-10-01

    Full Text Available Arie Y Nemet, Joseph R Ferencz, Ori Segal, Amit Meshi Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel Background: Acute or chronic infection of the scleral explant is rare. We report seven cases of scleral explant infections that caused orbital cellulitis. Materials and methods: This was a retrospective chart review of oculoplastics at oculoplastics and vitreo-retinal units in a secondary referral hospital. All subjects had orbital cellulitis secondary to scleral buckle in the range of January 1990 to March 2010. Demographics, imaging studies, and pathology specimens were reviewed. Results: A total of 841 silicone-sponge scleral buckle implants for rhegmatogenous retinal detachment were performed. Forty were extracted (4.75%; annual rate of 1.9 cases. Seven (0.83% had orbital cellulitis. The mean time from implantation to presentation was 5.7 years. There was bacterial growth in all specimens, with Staphylococcus aureus in four. Conclusions: Patients who are operated on with silicone-sponge scleral buckling for rhegmatogenous retinal detachment sometimes require removal of the implant because of infection. However, the infection rate is low. Patients should be followed in the long term for possible complications. Keywords: scleral explant infection, scleral buckle, orbital cellulitis, rhegmatogenous retinal detachment

  3. Achromobacter xylosoxidans Bacteremia and Cellulitis: A Report of a Case.

    Science.gov (United States)

    Dai, Julia; Huen, Auris O; Kestenbaum, Lori A; Sarezky, Margaret D; Coughlin, Carrie C; Yan, Albert C

    2015-01-01

    Achromobacter xylosoxidans is a rare, opportunistic infection most commonly encountered in immunocompromised patients during hospitalization. Primary uncomplicated bacteremia, catheter-associated infections, and pneumonia have been reported as the most common clinical presentations; skin and soft tissue infections from A. xylosoxidans are rare. We describe a case of A. xylosoxidans presenting as cellulitis and bacteremia in an immunocompromised patient.

  4. Orbital cellulitis in a neonate of the tooth bud origin : A case report

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    Poonam Lavaju

    2014-01-01

    Full Text Available Orbital cellulitis is a serious, yet uncommon infection in neonates. It can result in significant sight and life threatening complications. Most commonly, it occurs secondarily as the result of a spread of infection from the sinuses. Orbital cellulitis, secondary to dental infection is rare. We hereby report a case of orbital cellulitis secondary to dental infection in a 15-day-old neonate without any systemic features.

  5. Pneumococcal sepsis, peritonitis, and cellulitis at the first episode of nephrotic syndrome.

    Science.gov (United States)

    Naseri, Mitra

    2013-09-01

    Bacterial infections are common in patients with nephrotic syndrome, including peritonitis, sepsis, meningitis, urinary tract infection, and cellulitis. An 8-year-old boy presented with colicky abdominal pain, vomiting, swollen and painful erythematous lesions around the umbilicus and in anterior surface of left thigh (cellulitis), mild generalized edema, and ascites. The microorganism isolated from peritoneal fluid and blood cultures was Pneumococcus. Association of pneumococcal sepsis, peritonitis, and cellulitis has been rarely reported in nephrotic syndrome.

  6. Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment.

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    Devrim, Ilker; Kanra, Güler; Kara, Ateş; Cengiz, A Bülent; Orhan, Mehmet; Ceyhan, Mehmet; Seçmeer, Gülten

    2008-01-01

    The infection of the orbita and ocular tissues can result in severe local and systemic complications. We aimed to determine the predisposing factors for preseptal and orbital cellulitis, the clinical and routine laboratory differences between orbital and preseptal cellulitis, and the change in the spectrum of the pathogens and the antibiotics used in the last 10 years. One hundred thirty-nine patients, hospitalized in Hacettepe University Faculty of Medicine Children's Hospital between 1 January 1990 and 31 December 2003 with diagnosis ofperiorbital or orbital cellulitis, were reviewed retrospectively. Ten of the patients (7%) had orbital and 129 (93%) had preseptal cellulitis. The male/female ratio was 1.7:1. The average age (mean+/-standard deviation) was 5.7+/-4 years. The seasonal distribution was most marked in spring and fall periods. When compared with preseptal cellulitis, the mean blood cell count, erythrocyte sedimentation rate and C-reactive protein levels were significantly higher in patients with orbital cellulitis. Staphylococcus aureus was isolated in 13 (41.9% of total microbiologically confirmed cases), coagulase-negative staphylococcus in 8 (25.8%), and H. influenza type b in 2 patients (6%). Thirty out of 77 clinical sample cultures (39%) were positive. In clinical studies, etiological agents of orbital and preseptal cellulitis could be identified in only 20-30% of cases, so in clinical practice treatment is usually empiric. We observed that sulbactam-ampicillin was a safe and effective choice of treatment in orbital and preseptal cellulitis in our cases.

  7. Antimicrobial resistance of bacterial strains isolated from avian cellulitis

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    MM Santos

    2014-03-01

    Full Text Available Avian cellulitis is an inflammatory process in the subcutaneous tissue, mainly located in the abdomen and thighs. This problem is commonly observed in poultry at slaughter and it is considered one of the major causes of condemnation of carcasses in Brazil. The aim of this study was to perform the microbial isolation of lesions of avian cellulitis from a processing plant located in the State of Goiás in order to analyze antimicrobial resistance by antibiogram test and to detect resistance genes by polymerase chain reaction. A total of 25 samples of avian cellulitis lesions were analyzed, from which 30 bacterial strains were isolated. There were eleven (44% strains of Escherichia coli, nine (36% strains of Staphylococcus epidermidis, seven (28% strains of Proteus mirabilis and three (12% strains of Manheimiahaemolytica. The antibiogram test showed that all strains were resistant to at least one antimicrobial. The gene of antimicrobial resistance tetB was detected in E. coli, S. epidermidis and P. mirabilis strains, and was the most frequently observed gene. The gene of antimicrobial resistance Sul1 was detected in all bacterial species, while tetA was found in E. coli and S. epidermidis strains, SHV in E. coli strains, S. epidermidis and P. mirabilis,and cat1 in one P. mirabilis strain. The results suggest a potential public health hazard due to the ability of these microorganisms to transmit antimicrobial resistancegenes to other microorganisms present in the intestinal tract of humans and animals, which may affect clinical-medical usage of these drugs.

  8. Clinical and microbiologic features of dacryocystitis-related orbital cellulitis.

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    Wladis, Edward J; Shinder, Roman; LeFebvre, Daniel R; Sokol, Jason A; Boyce, Michelle

    2016-10-01

    Dacryocystitis-related orbital cellulitis is a relatively rare condition, and large case series of this clinical entity have been reported. This study was undertaken to identify a larger cohort of patients with this ailment, with the intent of defining its clinical and microbiologic features. Case logs from four institutions were reviewed to identify patients that suffered from dacryocystitis-related orbital cellulitis. A retrospective chart review was then performed to identify clinical features, management strategies, microbiologic features, and outcomes. A dedicated statistical software package was utilized to identify correlations between these variables. 13 patients (7 females, 6 males; mean age = 57.2 years, range = 7-89 years) were identified. One patient carried a diagnosis of immunosuppressive disease. All patients underwent emergent surgical drainage and received intravenous antibiotics. Primary acquired nasolacrimal duct obstruction was found to be the underlying etiology in nine cases (69.2%), whereas four patients suffered from specific causes of their obstructions. An average of 1.07 organisms/patient (standard deviation = 0.49 organisms/patient) were recovered from microbiologic cultures, and Gram-positive bacteria represented the majority of cultured organisms. All patients experienced either stable or improved vision upon discharge. The relationships between a specific etiology and the possibility of vision loss or the number of organisms cultured, between the number of organisms cultured and vision loss, and immunosuppression and vision loss or the number of organisms cultured were all not statistically significant (p > 0.05). Dacryocystitis-related orbital cellulitis most commonly occurs in adult patients who do not carry immunosuppressive diagnoses and suffer from primary obstructions. Multiple microbiologic species may cause this problem, although Gram-positive organisms are most common. With appropriate management, stable or improved vision

  9. Complete Vision Loss following Orbital Cellulitis Secondary to Acute Dacryocystitis

    Science.gov (United States)

    Pfeiffer, Margaret L.; Hacopian, Alexander; Merritt, Helen

    2016-01-01

    We present a case of a 50-year-old woman with acute dacryocystitis that was complicated by posterior rupture of the lacrimal sac causing an orbital cellulitis with subsequent visual acuity of no light perception. Upon presentation, she was immediately started on broad-spectrum antibiotics and underwent surgical incision and drainage of the lacrimal sac abscess but never regained vision. There are 4 cases in the literature of permanent severe vision loss from acute dacryocystitis. Prompt diagnosis and close monitoring of acute dacryocystitis are therefore essential to prevent extension into the orbit and possible optic nerve compromise.

  10. Orbital Cellulitis: A Rare Presentation of Metastatic Bronchial Carcinoma

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    Rohit Kumar

    2011-01-01

    Full Text Available Objective. We report a rare and unusual case of bronchial carcinoma presenting with symptoms of complications of sinonasal disease. Case Report. A 66-year-old lady was referred with a 1-week history of progressive ocular pain, chemosis, and visual disturbance. Computed tomography of the paranasal sinuses revealed frontal and ethmoidal sinus opacification with orbital involvement consistent with a diagnosis of orbital cellulitis secondary to sinusitis. Surgical exploration revealed that the sinuses and right orbit were filled with soft tissue and subsequent histopathological examination of the biopsies indicating metastases from an adenosquamous bronchial carcinoma. Further imaging revealed a large, asymptomatic, bronchial primary with deposits in the brain and liver. The advanced presentation of the disease limited treatment to best supportive care. Conclusion. Orbital cellulitis and sinonasal malignancies have a similar pattern of clinical presentation, posing a potential diagnostic pitfall. There are only two previously reported cases of metastatic lung carcinoma in the frontal sinus with 15 cases of sinonasal tract involvement reported overall. There are no reported cases of adenosquamous carcinoma in the sinonasal tract.

  11. Primary skeletal muscle lymphoma presenting as refractory cellulitis.

    Science.gov (United States)

    Baddour, L M; Haden, K H; Allen, J W

    2001-09-01

    The right torso of a 55-year-old woman showed diffuse skin and soft-tissue changes suggestive of cellulitis. However, several clinical and radiologic features, including the subacute and non-toxic nature of the illness and the patient's lack of response to antibiotic therapy, indicated a noninfectious etiology. Malignancy was suggested by striking changes seen on computed tomographic scanning--including extensive infiltration and enlargement of the musculature of the right shoulder girdle, the intercostal musculature, the latissimus dorsi, and the rhomboids; focal enlargement of the right paraspinal muscles; and enlargement of the psoas and the iliacus muscles and of the musculature around the hip joint. The mediastinal, hilar, and paraaortic regions showed no adenopathy. A large hypodense lesion of approximately 4.5 cm, which was seen in the caudate lobe of the liver, raised the concern of a metastatic focus of malignancy. Because of these findings, an immediate muscle biopsy was performed. Results showed a non-Hodgkin's lymphoma with a B-cell phenotype. Although primary skeletal muscle lymphoma is very uncommon in patients without human immunodeficiency virus infection, clinical presentation of refractory cellulitis, as seen in the current case, is extremely rare.

  12. Prospective study on sociodynamics of cellulitis in general surgical unit

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    Didde Sundara Chakravarthy

    2015-05-01

    Results: The median age of the participants was 62.5 years. The following risk factors were strongly and independently associated with cellulitis and outcome of the patient; illiteracy (OR, 4; P value 0.010, age above 50 years (OR, 0.110; P value 0.000, residing in rural areas (OR, 4.008; P value 0.006, low socioeconomic status (OR, 0.241; P value 0.030 and associated co-morbid conditions (OR, 0.390; P value, 0.032. Conclusion: Patients usually presented in the late stage of disease because of illiteracy, ignorance and poor knowledge. Patients should be educated to routinely inspect their feet, and the importance of appropriate footwear should be emphasized. Patients who are actively involved in their care can improve their quality of life and have a better outcome. [Int J Res Med Sci 2015; 3(5.000: 1052-1055

  13. Chemical Cellulitis due to Peanut Oil Administration. A Case Report

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    Julio César Turiño Muro

    2014-03-01

    Full Text Available Chemical cellulitis is the reaction of the integuments in response to the administration of toxic substances, leading to an acute inflammatory reaction that develops into an abscess or necrosis. This disease is not frequently treated in the Department of Orthopedics and Traumatology of the Joaquin Albarrán Clinical-Surgical Hospital. We present the case of a patient who attended our institution because of increased volume in both upper limbs at the biceps and triceps areas, and marked skin necrosis accompanied by lesions of axillary adenopathy, one as an abscess. Antibiotics were prescribed prior to the completion of cultures, antibiogram and dressing under anesthesia, at present the lesions are in the healing phase.

  14. Toxic scarlet fever complicating cellulitis: early clinical diagnosis is crucial to prevent a fatal outcome.

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    Lau, S K; Woo, P C; Yuen, K Y

    2004-04-01

    We describe a case of toxic scarlet fever in a healthy adult with streptococcal cellulitis of the right elbow as a result of skin abrasion. The clinical picture mimicked that of drug eruption after treatment of cellulitis with antibiotics. Among the five cases of scarlet fever complicating cellulitis, including the present one, reported in the English literature, four had severe systemic complications and two died. As a result of re-emergence of invasive streptococcal infections, clinicians should be aware of the differential diagnosis of scarlet fever in patients presenting with cellulitis and skin rash. Early clinical diagnosis is crucial to exclude drug eruptions, prompt initiation of antibiotic treatment, and prevention of the potentially fatal outcome.

  15. Peg-Interferon Alfa 2-b Related Cellulitis in a 40 Years Man

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    Shahnaaz Sali

    2016-01-01

    Full Text Available Background: Pegylated interferon and ribavirin are currently one of the accepted treatment for chronic Hepatitis C. Dermatologic complications of interferon have been reported, but to date a few cases of bacterial cellulitis; a rare and severe complication, have been published. Cellulitis is a common infectious process affecting the skin and subcutaneous tissues which results in significant morbidity and holds considerable healthcare costs.Cases Report: Herein, we report a case of chronic hepatitis C genotype 1a who was on medication since 8 weeks prior to developing leg cellulitis, an uncommon pegylated interferon injection site. Considering no other possible risk factors were found to be in favor of bacterial cellulitis, our case is unique in its kind. Some reports reveal necrotizing vasculitis as basis for cutaneous lesions, which could be due to the high concentrations of drug at the injection site, a toxic effect of the diluents, or an immunological reaction.Conclusion: According to the latter mechanism patients could develop bacterial cellulitis in their different organs. Conclusively, we propose the hypothesis of a possible association between cellulitis to occur at any site as the complication of pegylated interferon Alfa 2b and would highlight the role of a careful skin examination that could be an asset in preventing local skin infections.

  16. Bacterial Etiology and Risk Factors Associated with Cellulitis and Purulent Skin Abscesses in Military Trainees

    Science.gov (United States)

    Johnson, Ryan C.; Ellis, Michael W.; Schlett, Carey D.; Millar, Eugene V.; LaBreck, Patrick T.; Mor, Deepika; Elassal, Emad M.; Lanier, Jeffrey B.; Redden, Cassie L.; Cui, Tianyuan; Teneza-Mora, Nimfa; Bishop, Danett K.; Hall, Eric R.; Bishop-Lilly, Kimberly A.

    2016-01-01

    Military trainees are at high risk for skin and soft-tissue infections (SSTIs). Although Staphylococcus aureus is associated with purulent SSTI, it is unclear to what degree this pathogen causes nonpurulent cellulitis. To inform effective prevention strategies and to provide novel insights into SSTI pathogenesis, we aimed to determine the etiology of SSTI in this population. We conducted a prospective observational study in US Army Infantry trainees with SSTI (cutaneous abscesses and cellulitis) from July 2012 through December 2014. We used standard microbiology, serology, and high-throughput sequencing to determine the etiology of SSTI. Furthermore, we compared purported risk factors as well as anatomic site colonization for S. aureus. Among 201 SSTI cases evaluated for SSTI risk factors, cellulitis was associated with lower extremity blisters (P = 0.01) and abscess was associated with methicillin-resistant S. aureus (MRSA) colonization (Pmicrobiome analysis, only 1 leading edge aspirate was culturable (Coagulase-negative Staphylococcus). Microbiome evaluation of aspirate specimens demonstrated that Rhodanobacter terrae was the most abundant species (66.8% average abundance), while abscesses were dominated by S. aureus (92.9% average abundance). Although abscesses and cellulitis share the spectrum of clinical SSTI, the bacterial etiologies as determined by current technology appear distinct. Furthermore, the presence of atypical bacteria within cellulitis aspirates may indicate novel mechanisms of cellulitis pathogenesis. Clinical Trials Registration: NCT01105767. PMID:27780238

  17. Cervical cellulitis and mediastinitis following esophageal perforation: A case report

    Institute of Scientific and Technical Information of China (English)

    Christian A Righini; Basilide Z Tea; Emile Reyt; Karim A Chahine

    2008-01-01

    Chicken bone is one of the most frequent foreign bodies (FB) associated with upper esophageal perforation.Upper digestive tract penetrating FB may lead to life threatening complications and requires prompt management.We present the case of a 52-year-old man who sustained an upper esophageal perforation associated with cervical cellulitis and mediastinitis.Following CT-scan evidence of FB penetrating the esophagus,the impacted FB was successfully extracted under rigid esophagoscopy.Direct suture was required to close the esophageal perforation.Cervical and mediastinal drainage were made immediately.Nasogastric tube decompression,broad-spectrum intravenous antibiotics,and parenteral hyperalimentation were administered for 10 d postoperatively.An esophagogram at d 10 revealed no leak at the repair site,and oral alimentation was successfully reinstituted.Conclusion:Rigid endoscope management of FB esophageal penetration is a simple,safe and effective procedure.Primary esophageal repair with drainage of all affected compartments are necessary to avoid life-threatening complications.

  18. Nine years’ review on preseptal and orbital cellulitis and emergence of community–acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India

    OpenAIRE

    Pandian, Datta G; Babu, Ramesh K; Chaitra, A; A Anjali; Vasudev A Rao; Renuka Srinivasan

    2011-01-01

    Context: Preseptal cellulitis is the commonest orbital disease which frequently needs to be differentiated from orbital cellulitis. Prompt diagnosis and treatment with appropriate antibiotics can prevent vision loss and life-threatening complications of orbital cellulitis. Aims: To describe the clinical profile of cases with preseptal and orbital cellulitis admitted to a tertiary care hospital during a period of nine years. The causative organisms and the clinical outcome were analyzed. Setti...

  19. A case of odontogenic orbital cellulitis causing blindness by severe tension orbit.

    Science.gov (United States)

    Park, Chang Hyun; Jee, Dong Hyun; La, Tae Yoon

    2013-02-01

    We report a very rare case of odontogenic orbital cellulitis causing blindness by severe tension orbit. A 41-yr old male patient had visited the hospital due to severe periorbital swelling and nasal stuffiness while he was treated for a periodontal abscess. He was diagnosed with odontogenic sinusitis and orbital cellulitis, and treated with antibiotics. The symptoms were aggravated and emergency sinus drainage was performed. On the next day, a sudden decrease in vision occurred with findings of ischemic optic neuropathy and central retinal artery occlusion. Deformation of the eyeball posterior pole into a cone shape was found from the orbital CT. A high-dose steroid was administered immediately resulting in improvements of periorbital swelling, but the patient's vision had not recovered. Odontogenic orbital cellulitis is relatively rare, but can cause blindness via rapidly progressing tension orbit. Therefore even the simplest of dental problems requires careful attention.

  20. [Cellulitis due to Achromobacter xylosoxidans during bortezomib therapy for multiple myeloma].

    Science.gov (United States)

    Kikuchi, Taku; Mori, Takehiko; Kohashi, Sumiko; Yamane, Yusuke; Okayama, Mikio; Mashima, Eri; Murakami, Koichi; Shimizu, Takayuki; Kurihara, Yuichi; Ueda, Tomomi; Suzuki, Takeshi; Okamoto, Shinichiro

    2016-02-01

    Achromobacter xylosoxidans (A. xylosoxidans) is a non-fermentative gram-negative rod. This organism is reportedly a causative pathogen of bacteremia mainly in patients with hematological disorders. However, only one case of cellulitis due to A. xylosoxidans associated with hematological malignancy has been reported. An 80-year-old man developed cellulitis and subsequent bacteremia due to A. xylosoxidans during bortezomib therapy for multiple myeloma. Although his condition was serious enough to require intensive care, he fully recovered with appropriate antimicrobial agents and supportive care. The isolate was broadly resistant to antimicrobial agents, including cefepime, amikacin, and ciprofloxacin. Therefore, the identification and selection of appropriate antimicrobial agents were considered to have contributed to the successful outcome in this case. Physicians should recognize A. xylosoxidans as a possible pathogen causing cellulitis and secondary bacteremia, as well as being aware of its broad resistance to antimicrobial agents.

  1. Group a streptococcal cellulitis in the early puerperium

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    Nikolić Branka

    2011-01-01

    Full Text Available Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerperium. However, there are two main problems with GAS infection in early puerperium and this case report is aimed at reminding on them. The first problem is an absence of awareness that it can be postpartal invasive GAS infection before the microbiology laboratory confirms it, and the second one is that we have little knowledge about GAS infection, in general. Case report. A 32- year-old healthy woman, gravida 1, para 1, was hospitalized three days after vaginal delivery with a 38-hour history of fever, pain in the left leg (under the knee, and head injury after short period of conscious lost. Clinical picture of GAS infection was cellulites. Group A Streptoccocus pyogenes was isolated in vaginal culture. Rapid antibiotic and supportive treatment stopped development of streptococcal toxic shock syndrome (STSS and potential multiorganic failure. Signs and symptoms of the infection lasted 25 days, and complete recovery of the patient almost 50 days. Conclusion. In all women in childbed with a history of fever early after delivery, vaginal and cervical culture specimens should be taken as soon as possible. Early recognition of GAS infection in early puerperium and prompt initiation of antimicrobial drug and supportive therapy can prevent development of STSS and lethal outcome.

  2. ETUDE ET SIMULATION DE CELLULES PHOTOVOLTAIQUES A COUCHES MINCES A BASE DE CIS et CIGS

    OpenAIRE

    MOSTEFA KARA, Selma

    2012-01-01

    Dans le contexte global de la diversification de l’utilisation des ressources naturelles, le recours aux énergies renouvelables et en particulier le solaire photovoltaïque se fait de plus en plus fort. A ce titre, le développement d’une nouvelle génération de cellules photovoltaïques à base de Cu(In,Ga)Se2 semble prometteur. En effet, le rendement de ces cellules a dépassé les 20% ces dernières années. Dans ce travail de modélisation et de simulation, nous utilisons le logiciel Si...

  3. A case of community-acquired Acinetobacter junii-johnsonii cellulitis.

    Science.gov (United States)

    Henao-Martínez, Andrés F; González-Fontal, Guido R; Johnson, Steven

    2012-06-01

    Acinetobacter skin and soft tissue infection outside of the traumatic wound setting are rare occurrences. The majority of cases occur in the presence of significant comorbilities and by Acinetobacter baumanii. Herein a case is reported of community-onset, health-care-associated, non-traumatic cellulitis caused by Acinetobacter, species junii-johnsonii with bacteremia. This is the first reported case of Acinetobacter junii-johnsonii skin and soft tissue infection. Hemorrhagic bullae might be one of the clinical features of Acinetobacter cellulitis.

  4. Concurrent Infections of Conidiobolus Coronatus with Disseminated Tuberculosis Presenting as Bilateral Orbital Cellulitis

    OpenAIRE

    John, Deepa; Irodi, Aparna; Michael, Joy Sarojini

    2016-01-01

    Zygomycetes species contains two orders of organisms that infect humans, namely Mucorales and Entomophthorales. Entomophthorales cause chronic infection in immunocompetent patients, invading subcutaneous tissues but are non-angioinvasive. This includes Basidiobolus ranarum, Conidiobolus incongruus and Conidiobolus coronatus. We report a case of disseminated tuberculosis with Conidiobolus coronatus infection presenting as orbital cellulitis in an adolescent.

  5. Panophthalmitis with orbital cellulitis following glaucoma drainage implant surgery in a pediatric patient

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    Bruno L. B. Esporcatte

    2016-04-01

    Full Text Available ABSTRACT Here we report a case of childhood glaucoma refractory to angle and trabeculectomy surgery. The patient was treated with an Ahmed™ drainage implant that was subsequently complicated by rapid-onset panophthalmitis and orbital cellulitis. Intravenous and intravitreal antibiotic therapy was initiated and the drainage tube was removed. The infectious process resolved within 3 weeks; however, phthisis bulbi developed subsequently.

  6. Current trends in treatment outcomes of orbital cellulitis in a tertiary hospital in Southern Nigeria

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    Odarosa M Uhumwangho

    2016-01-01

    Full Text Available Background: Orbital cellulitis refers to the inflammation or infection of the soft tissues of the orbit located behind the orbital septum. Aim: To determine the current trends in the outcomes following the management of orbital cellulitis in a tertiary hospital in Southern Nigeria. Patients and Methods: A retrospective review of medical records of patients with orbital cellulitis from January 2008 to December 2014 was conducted. The age, sex, duration of symptoms, predisposing factors, clinical findings, laboratory/radiological investigations, treatment provided, complications, and follow-up were recorded. Results were analyzed with SPSS Version 21 program. Results: Forty-two patients were seen made of 17 (40.5% males and 25 (59.5% females with a mean age of 18.2 ± 18.7 years of which children 6/18 at presentation, 38 (82.6% and at discharge, 39 (84.8%. The mean duration of presenting complaints was 15.5 ± 31.6 days. Patients who presented early were less likely to develop complications, P = 0.003. The most common complication was exposure keratopathy in 8 (44.4% eyes. The only surgical intervention performed was incision and drainage of abscess in 3 (7.1% eyes. No patient came for follow-up. Conclusion: Prompt institution of effective antibiotics and management of complications that may arise improves prognosis of orbital cellulitis.

  7. Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature.

    Science.gov (United States)

    Clark, Jeremy D; Fernandez de Castro, Juan P; Compton, Chris; Lee, Harold; Nunery, William

    2016-06-01

    Cedecea is a gram-negative bacterium from the family Enterobacteriaceae, rarely associated with human infection. We report the first case of an orbital cellulitis and corneal ulcer due to Cedecea in a patient who sustained a motor vehicle accident and was then found to have a retained wooden orbital foreign body.

  8. An aggressive group a streptococcal cellulitis of the hand and forearm requiring surgical debridement.

    Science.gov (United States)

    Bharucha, Neil J; Alaia, Michael J; Paksima, Nader; Christoforou, Dimitrios; Gupta, Salil

    2011-01-03

    Group A streptococcus is responsible for a diverse range of soft tissue infections. Manifestations range from minor oropharyngeal and cellulitic skin infections to more severe conditions such as necrotizing fasciitis and septic shock. Troubling increases in the incidence and the severity of streptococcal infections have been reported over the past 25 years. Cases of streptococcal necrotizing fasciitis have received significant attention in the literature, with prompt surgical debridement being the mainstay of treatment. However, cases of rapidly progressing upper extremity streptococcal cellulitis leading to shock and a subsequent surgical intervention have not been well described. This article presents a case of an 85-year-old woman with a rapidly progressing, erythematous, painful, swollen hand associated with fever, hypotension, and mental status change. Due to a high clinical suspicion for necrotizing fasciitis, the patient was rapidly resuscitated and underwent immediate surgical irrigation and debridement. All intraoperative fascial pathology specimens were negative for necrotizing fasciitis, leading to a final diagnosis of Group A streptococcal cellulitis. Although surgical intervention is not commonly considered in patients with cellulitis, our patient benefited from irrigation and debridement with soft tissue decompression. In cases of necrotizing fasciitis as well as rapidly progressive cellulitis, prompt diagnosis and aggressive treatment may help patients avoid the catastrophic consequences of rapidly progressive group A streptococcal infections.

  9. Nine years′ review on preseptal and orbital cellulitis and emergence of community-acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India

    Directory of Open Access Journals (Sweden)

    Datta G Pandian

    2011-01-01

    Full Text Available Context: Preseptal cellulitis is the commonest orbital disease which frequently needs to be differentiated from orbital cellulitis. Prompt diagnosis and treatment with appropriate antibiotics can prevent vision loss and life-threatening complications of orbital cellulitis. Aims: To describe the clinical profile of cases with preseptal and orbital cellulitis admitted to a tertiary care hospital during a period of nine years. The causative organisms and the clinical outcome were analyzed. Settings and Design : Retrospective descriptive case study done in a tertiary care hospital in South India. Material and Methods: The in-patient records of patients with preseptal and orbital cellulitis were reviewed from 1998 to 2006. The factors reviewed included ocular findings aiding in the distinction of the two clinical conditions, the duration of symptoms, the duration of hospital stay, microbiological culture report of pus or wound swab, blood culture, drugs used for treatment, the response to therapy and complications. Statistical Analysis Used: Descriptive analysis. Results: One hundred and ten cases, 77 patients with preseptal cellulitis and 33 patients with orbital cellulitis were reviewed. Five percent of children and 21% of adults presented with cutaneous anthrax contributing to preseptal cellulitis. Thirty-nine percent cases with orbital cellulitis were caused by methicillin-resistant Staphylococcus aureus (MRSA. Conclusions: This study has helped in identifying organisms which cause orbital infections, especially community-acquired MRSA. It indicates the need for modifying our empirical antimicrobial therapy, especially in orbital cellulitis.

  10. Predictors of a Positive Duplex Scan in Patients with a Clinical Presentation Compatible with Deep Vein Thrombosis or Cellulitis

    Directory of Open Access Journals (Sweden)

    Curtis E Rabuka

    2003-01-01

    Full Text Available BACKGROUND: Deep vein thrombosis (DVT and cellulitis are common conditions whose symptoms lead patients to seek medical attention in the emergency department (ED. Distinguishing between these two conditions quickly and accurately is important.

  11. Mycobacterium avium-intracellulare cellulitis occurring with septic arthritis after joint injection: a case report

    Directory of Open Access Journals (Sweden)

    Murdoch David M

    2007-02-01

    Full Text Available Abstract Background Cellulitis caused by Mycobacterium avium-intracellulare has rarely been described. Mycobacterium avium-intracellulare is a rare cause of septic arthritis after intra-articular injection, though the causative role of injection is difficult to ascertain in such cases. Case presentation A 57-year-old with rheumatoid arthritis treated with prednisone and azathioprine developed bilateral painful degenerative shoulder arthritis. After corticosteroid injections into both acromioclavicular joints, he developed bilateral cellulitis centered over the injection sites. Skin biopsy showed non-caseating granulomas, and culture grew Mycobacterium avium-intracellulare. Joint aspiration also revealed Mycobacterium avium-intracellulare infection. Conclusion Although rare, skin and joint infections caused by Mycobacterium avium-intracellulare should be considered in any immunocompromised host, particularly after intra-articular injection. Stains for acid-fast bacilli may be negative in pathologic samples even in the presence of infection; cultures of tissue specimens should always be obtained.

  12. Facing the Danger Zone: The Use of Ultrasound to Distinguish Cellulitis from Abscess in Facial Infections

    Directory of Open Access Journals (Sweden)

    Dywanda L. Lewis

    2014-01-01

    Full Text Available Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1 emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2 demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3 depict an instance where ultrasound detected an abscess when computed tomography (CT scan did not.

  13. Densità e distribuzione delle cellule di Purkinje nel cervelletto di cane: studio immunoistochimico

    OpenAIRE

    Ruffini, Alessia

    2016-01-01

    Nella letteratura, gli studi morfologici e morfometrici del cervelletto di animali ed esseri umani, hanno valutato il numero di cellule di Purkinje (CP) solo su alcuni campi a random. Gli studi sono stati spesso condotti su cervelletti fissati in formalina e inclusi in paraffina; gli studi effettuati su campioni congelati sono molto rari. Gli scopi del presente studio sono stati: quantificare il numero e la distribuzione delle CP in tutto il tessuto cerebellare; valutare lo spessore del gr...

  14. Disseminated cryptococcosis presenting as cutaneous cellulitis in an adolescent with systemic lupus erythematosus

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    Ellen Simionato Valente

    2015-06-01

    Full Text Available We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

  15. Disseminated Cryptococcosis Presenting as Cutaneous Cellulitis in an Adolescent With Systemic Lupus Erythematosus.

    Science.gov (United States)

    Valente, Ellen Simionato; Lazzarin, Mauricio Costa; Koech, Bruno Lopes; da Rosa, Ralph Vighi; de Almeida, Rafael; de Oliveira, Umberto Lopes; Neugebauer, Maria Gertrudes Fernandes Pereira; Sacco, Alexander Gonüalves

    2015-04-15

    We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

  16. Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

    OpenAIRE

    Sachiko Sakamoto; Naoki Oiso; Masakatsu Emoto; Shusuke Uchida; Ayaka Hirao; Yoichi Tatsumi; Itaru Matsumura; Akira Kawada

    2012-01-01

    Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression. Acute promyelocytic leukemia (acute myeloid leukemia M3) is caused by translocation of reciprocal chromosomal rearrangement t(15;17), which produces an oncogenic protein. We herein describe a 71-year-old man having cellulitis with leukocytopenia as a first sign of acute promyelocytic leukemia. Dermatologists and hematologists should keep in min...

  17. A Woman with Unilateral Rash and Fever: Cellulitis in the Setting of Lymphedema

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    Melissa Joseph

    2015-01-01

    Full Text Available Cellulitis in the setting of lymphedema is an uncommon but clinically important presentation to the emergency department. Stagnant lymph is an ideal medium for bacterial growth and progression can be rapid due to decreased ability to fight infection in the affected area. Infections are commonly caused by gram-positive cocci, though blood cultures are often negative. Treatment should be aimed at rapid initiation of antibiotics targeting these species. There may be a role for antibiotic prophylaxis in recurrent cases.

  18. Successful endoscopic management with Mitomycin C application for sinusitis with orbital cellulitis

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    Anil S Harugop

    2013-01-01

    Full Text Available Background: Sinusitis with orbital complication is a potentially fatal disease that has been known since the days of Hippocrates. Primary sinus infection is the most common cause of orbital cellulitis. It is an emergency that threatens not only vision but also life from complications such as meningitis, cavernous sinus thrombosis, and brain abscess. Surgical intervention is mandatory whenever antibiotic treatment fails. There are two surgical options for the drainage, an external approach via a Lynch incision and an intranasal endoscopic procedure. Materials and Methods: Five patients with orbital cellulitis secondary to acute on chronic rhinosinusitis were included in the study from the period of 2010 - 2011. All five patients did not respond to medical management and hence underwent endoscopic sinus surgery with treatment of orbital pathology. At the end of the surgical procedure Mitomycin C in a concentration of 0.4mg/ml was applied with a cottonoid for a period of 4 minutes to prevent chance of adhesion formation. Results: In this series 3 females and 2 male patient with orbital cellulitis secondary to acute on chronic rhinosinusitis underwent endoscopic sinus surgery with treatment of orbital pathology. All 5 patients showed subjective and objective improvement within one week of endoscopic management. Conclusion: Though antibiotics have altered the course of sinusitis, its grave complications still persist in our environment. The excellent results and the absence of any major complications of endoscopic sinus surgery and drainage of abscess with application of Mitomycin C can be recommended as the preferred surgical technique.

  19. European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate

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    Tsironi Evangelia E

    2012-05-01

    Full Text Available Abstract Background Methicillin-resistant Staphylococcus aureus is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, to our knowledge, the first detailed description of a community-associated methicillin-resistant S. aureus ST80 orbital cellulitis in a previously healthy neonate. Possible predisposing factors of microbial acquisition and treatment selection are also discussed. Case presentation A 28-day-old Caucasian boy was referred to our hospital with the diagnosis of right orbital cellulitis. His symptoms included right eye proptosis, periocular edema and redness. Empirical therapy of intravenous daptomycin, rifampin and ceftriaxone was initiated. The culture of pus yielded a methicillin-resistant S. aureus isolate and the molecular analysis revealed that it was a Panton-Valentine leukocidine-positive ST80 strain. The combination antimicrobial therapy was continued for 42days and the infection was successfully controlled. Conclusions Clinicians should be aware that young infants, even without any predisposing condition, are susceptible to orbital cellulitis caused by community-associated methicillin-resistant S. aureus. Prompt initiation of the appropriate empirical therapy, according to the local epidemiology, should successfully address the infection, preventing ocular and systemic complications.

  20. Inflammatory tinea capitis mimicking dissecting cellulitis in a postpubertal male: a case report and review of the literature.

    Science.gov (United States)

    Stein, Loretta L; Adams, Erin G; Holcomb, Katherine Z

    2013-09-01

    Tinea capitis in postpubertal patients is unusual and may be misdiagnosed as dissecting cellulitis. We report a case of a healthy 19-year-old Hispanic male presenting with a 2-month history of a large, painful subcutaneous boggy plaque on the scalp with patchy alopecia, erythematous papules, cysts and pustules. Although initially diagnosed as dissecting cellulitis, potassium hydroxide evaluation (KOH preparation) of the hair from the affected region was positive. A punch biopsy of the scalp demonstrated endothrix consistent with tinea capitis, but with a brisk, deep mixed inflammatory infiltrate as can be seen with chronic dissecting cellulitis. Fungal culture revealed Trichophyton tonsurans, and a diagnosis of inflammatory tinea capitis was made. The patient was treated over the course of 17 months with multiple systemic and topical antifungal medications, with slow, but demonstrable clinical and histopathological improvement. A rare diagnosis in adults, clinicians should have a high index of suspicion for this condition in an adult with an inflammatory scalp disorder not classic for dissecting cellulitis or with a recalcitrant dissecting cellulitis. Prompt, appropriate diagnosis and treatment is necessary to prevent the long-term complications of scarring alopecia.

  1. Infectious diseases specialist management improves outcomes for outpatients diagnosed with cellulitis in the emergency department: a double cohort study.

    Science.gov (United States)

    Jain, Shilpa R; Hosseini-Moghaddam, Seyed M; Dwek, Philip; Gupta, Kaveri; Elsayed, Sameer; Thompson, Guy W; Dagnone, Robert; Hutt, Kelly; Silverman, Michael

    2017-04-01

    Three hospital emergency rooms (ERs) routinely referred all cases of cellulitis requiring outpatient intravenous antibiotics, to a central ER-staffed cellulitis clinic. We performed a retrospective cohort study of all patients seen by the ER clinic in the last 4months preceding a policy change (ER management cohort [ERMC]) (n=149) and all those seen in the first 3months of a new policy of automatic referral to an infectious disease (ID) specialist-supervised cellulitis clinic (ID management cohort [IDMC]) (n=136). Fifty-four (40%) of 136 patients in the IDMC were given an alternative diagnosis (noncellulitis), compared to 16 (11%) of 149 in the ERMC (P<0.0001). Logistic regression-demonstrated rates of disease recurrence were lower in the IDMC than the ERMC (hazard ratio [HR], 0.06; P=0.003), as were rates of hospitalization (HR, 0.11; P=0.01). There was no significant difference in mortality. Automatic ID consultation for cellulitis was beneficial in differentiating mimickers from true cellulitis, reducing recurrence, and preventing hospital admissions.

  2. Serratia marcescens Bullous Cellulitis in a Splenectomized Patient: A Case Report and Review of the Literature.

    Science.gov (United States)

    Fournier, John B; Dabiri, Ganary; Thomas, Vinod; Skowron, Gail; Carson, Polly; Falanga, Vincent

    2016-06-01

    Serratia marcescens is a Gram-negative bacillus belonging to the Enterobacteriaceae family. Cutaneous infection with Serratia is rare, and usually occurs in immunocompromised individuals. Primary cutaneous infections are uncommon, but they are typically severe and are associated with significant morbidity and mortality. The pathogenetic factors leading to S. marcescens infection are not fully understood, but contributing virulence factors include proteases, secreted exotoxins, and the formation of biofilm. We report a case of cellulitis occurring in a splenectomized patient, which led to multiple wound debridements and a transmetatarsal amputation. This dramatic case led us to review the published literature on soft tissue infections caused by S. marcescens.

  3. [Acute renal failure in a young male with cellulitis in the lower leg].

    Science.gov (United States)

    Rodríguez Lorenzo, A; Martelo Villar, F

    2008-06-01

    Necrotizing fascitiis due to Streptococcus Pyogenes has a high mortality rate. Detection of the infection before it developes to the streptococcal toxic shock syndrome is quite challenging and its one of the main goals of its management because at this final stage the treatment is in most of the cases ineffective. In a secuence of events of the progression of the infection to shock, renal failure occurs before hipotension very often. We report the case of a 38-year-old patient affected by a fulminant necrotizing fascitiis by Streptococcus Pyogenes which presented at admission with lower leg cellulitis and acute renal failure.

  4. Amelioration_du_Rendement_Energetique_de_Cellules_Photovoltaïques_en_Couches_Minces_a_base_de_CZTS.

    OpenAIRE

    BOUDJERAD_epouse_MEGHNINE, Fatiha

    2014-01-01

    Dans le contexte global de la diversification de l’utilisation des ressources naturelles, le recours aux énergies renouvelables et en particulier le solaire photovoltaïque se fait de plus en plus fort. A ce titre, le développement d’une nouvelle génération de cellules photovoltaïques à base de CuZnSnS4 (CZTS) semble prometteur. En effet, le rendement de ces cellules a dépassé les 30% ces dernières années. Dans ce travail de modélisation et de simulation, nous utilisons le logic...

  5. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

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    Soma Mukherjee

    2013-01-01

    Full Text Available Ludwig′s angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregnancy, lest life-threatening complications like Ludwig′s angina occur, complicating the course of pregnancy.

  6. An unusual pathogen in ambulatory care: two cases of Scedosporium soft tissue infections presenting as "unresponsive cellulitis".

    Science.gov (United States)

    Misselbrook, Gary Peter; Lillie, Patrick; Thomas, Claire P

    2016-01-01

    Soft tissue infections with Scedosporium spp. are an uncommon but serious and emerging cause of infection in immunocompromised patients. Acute Medical Units (AMUs) in the UK are increasingly managing patients with cellulitis in an outpatient setting, therefore acute physicians should be aware of some of the more uncommon causes of soft tissue infection, particularly in patients not responding to initial antibiotic therapy. We present two cases of Scedosporium presenting to the AMU as cellulitis not responding to initial antibiotic therapy and outline the assessment and management of this important condition.

  7. Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis

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    Giuseppe Valacchi

    2015-08-01

    Full Text Available Objectives: Ambient air pollution, as many publications indicate, may have associations with skin condition. The aim of this study has been to examine such common relations for cellulitis and pharyngitis. The hypothesis is that ambient ground-level ozone may help bacteria to penetrate skin or throat. Material and Methods: We used the emergency department (ED visits data in Edmonton, Canada for the period from 1992 (April to 2002 (March. We retrieved all the diagnosed ED visits for cellulitis and pharyngitis. Case-crossover design was used to study potential association between ozone and those visits. Conditional logistic regression was used to estimate odds ratios (OR and their 95% confidence intervals (95% CI. Results: The results are reported for the interquartile range (IQR = 17.9 ppb for 8 h maximum ozone. Positive and statistical significant results were obtained as follows: for lags from 0 to 3 (OR = 1.07, 95% CI: 1.03–1.12, lag 2; for lags from 0 to 6 days (OR = 1.08, 95% CI: 1.03–1.12, lag 3; for lags from 0 to 4 (OR = 1.06, 95% CI: 1.03–1.09, for lag 2 and 3. Conclusions: The findings suggest the response to exposure to ambient ground-level ozone for skin and pharyngitis considered separately and jointly.

  8. A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.

    LENUS (Irish Health Repository)

    Quirke, M

    2014-11-01

    To characterise the Emergency Department (ED) prevalence of cellulitis, factors predicting oral antibiotic therapy and the utility of the Clinical Resource Efficiency Support Team (CREST) guideline in predicting patient management in the ED setting, a prospective, cross-sectional study of consecutive adult patients presenting to 3 Irish EDs was performed. The overall prevalence of cellulitis was 12 per 1,000 ED visits. Of 59 patients enrolled, 45.8% were discharged. Predictors of treatment with oral antibiotics were: CREST, Class 1 allocation (odds ratio (OR) 6.81, 95% Cl =1.5-30.1, p=0.012), patient self-referral (OR= 6.2, 95% Cl 1.9- 20.0, p=0.03) and symptom duration longer than 48 hours (OR 1.2, 95% Cl = 1.0-1.5,p=0.049). In conflict with guideline recommendation, 43% of patients in CREST Class 1 received IV therapy. Treatment with oral antibiotics was predicted by CREST Class 1 allocation, self-referral, symptom duration of more than 48 hours and absence of pre-EO antibiotic therapy.

  9. Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis

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    Rebecca Sin Mei Lim

    2013-01-01

    Full Text Available We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.

  10. Campylobacter fetus Bacteremia Revealed by Cellulitis without Gastrointestinal Symptoms in the Context of Acquired Hypogammaglobulinemia: A Report of Three Cases

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    Souleymane Brah

    2011-01-01

    Full Text Available Campylobacter fetus bacteremia is rare and occurs mainly in patients with immunosuppression. This infection, which often involves secondary localizations has already been reported in some primary humoral immune deficiencies. We describe three cases of severe infection due to C. fetus with cellulitis at presentation, but without any gastrointestinal symptoms, occurring in patients with acquired hypogammaglobulinemia.

  11. The acute orbit: Differentiation of orbital cellulitis from subperiosteal abscess by computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Handler, L.C.; Davey, I.C. (Groote Schuur Hospital, Cape Town (South Africa). Dept. of Neuroradiology Cape Town Univ. (South Africa)); Hill, J.C.; Lauryssen, C. (Groote Schuur Hospital, Cape Town (South Africa). Dept. of Ophthalmology Cape Town Univ. (South Africa))

    1991-02-01

    A series of 65 patients suffering from acute inflammatory disease of the orbit was studied by CT. Ethmoiditis was the cause in the vast majority; trauma and dental extraction played a lesser role in causation. Orbital cellulitis was diagnosed in 17 and subperiosteal abscess in the remaining 48. It was not possible to differentiate 33 pus-containing abscesses from the six with inflammatory masses (phlegmons). The satisfactory response to aggressive medical treatment in those patients with inflammatory masses that were not drained justifies a more conservative approach; surgical drainage being reserved for those with a deterioration in proptosis, ocular movements or vision. Six abscesses arose de novo, of which some were in the orbital fat rather than the subperiosteal space. (orig.).

  12. [Macrolane®: A severe case of calf cellulitis after modeling injection].

    Science.gov (United States)

    Chaput, B; Eburdery, H; Crouzet, C; Grolleau, J-L; Chavoin, J-P; Garrido, I

    2012-02-01

    In recent years, the market for resorbable injectables has been steadily expanding. The European Community's seal of approval (CE) is a sufficient guaranty to get them distributed. These injectables do not require official approval because they are considered to be "implantable medical devices" and not medicines. Macrolane(®)is a hyaluronic acid in gel form (NASHA [non-animal stabilized hyaluronic acid]) and has been on the French market since 2007. It can be injected into all areas except the face. It is highly cross-linked which, while slowing its absorption into the body, can also leave long-lasting residues. We report the first case of cellulitis after injection into the calf by a practitioner in his office.

  13. Facial and Periorbital Cellulitis due to Skin Peeling with Jet Stream by an Unauthorized Person

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    Asli Feride Kaptanoglu

    2014-01-01

    Full Text Available Technologies and devices for cosmetic procedures are developing with each passing day. However, increased and unauthorized use of such emerging technologies may also lead to increases in unexpected results and complications as well. Here, we report a case of facial cellulitis after a “beauty parlor” session of skin cleaning with jet stream peeling device in 19-year old female patient for the first time. Complications due to improper and unauthorized use of jet stream peeling devices may also cause doubts about the safety and impair the reputation of the technology as well. In order to avoid irreversible complications, local authorities should follow the technology and update the regulations where the dermatologists should take an active role.

  14. 眼外伤致眶蜂窝组织炎的护理%Nursing of Oribital Cellulitis Caused by Eye Injury

    Institute of Scientific and Technical Information of China (English)

    林丽萍; 胡淑英; 陈少娜

    2002-01-01

    To sum up 20 cases of nursing Oribital cellulitis caused by eye injury and suggest that it is important fornursing to pay close attention to patient's condition, to prevent cross infection and psychological nursing and to publicizehygiene element knowledge.

  15. Dissecting cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): a comprehensive review focusing on new treatments and findings of the last decade with commentary comparing the therapies and causes of dissecting cellulitis to hidradenitis suppura

    OpenAIRE

    Scheinfeld, Noah

    2014-01-01

    Dissecting cellulitis (DC) also referred to as to as perifolliculitis capitis abscedens et suffodiens (Hoffman) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. In the U.S., it predominantly occurs in African American men between 20-40 years of age.  DC also occurs in other races and women more rarely.  DC has been reported worldwide.  Older therapies reported effective include: low dose oral zinc, isotretinoin, minocycline, sulfa drug...

  16. Carcinoma a cellule basali: l'esperienza della dermatologia dell'Universita' di Bologna dal 1990 al 2014

    OpenAIRE

    Gaspari, Valeria

    2015-01-01

    Il carcinoma a cellule basali (BCC) costituisce l'80 peercento dei tumori cutanei non-melanoma, rappresentando dunque il tumore maligno della cute più frequente nella popolazione generale. Tuttavia, non esistono ad oggi studi epidemiologici ampi ed approfonditi condotti su scala nazionale su questo tipo di neoplasia, poichè i tumori cutanei non-melanoma sono esclusi dal registro statistico dei tumori. A tale scopo presso la Dermatologia dell'Università di Bologna sono stati raccolti di tut...

  17. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    Directory of Open Access Journals (Sweden)

    Juan S. Lasa

    2012-08-01

    Full Text Available La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB. Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celulitis. Se analizaron retrospectivamente los registros clínicos de los pacientes con este diagnóstico al ingreso entre junio de 2007 y marzo de 2010. Se evaluaron los datos poblacionales, presencia de comorbilidades, y resultados de los cultivos. En ese período, se internaron 140 pacientes con diagnóstico de celulitis y a todos ellos se les realizó hemocultivo y cultivos de PPB. Setenta y cuatro eran varones (52.8%. La edad promedio: 47.5 ± 19.7 años (rango 16-94. El 40% tuvo cultivos positivos de PPB, en los que el Staphylococcus aureus meticilino resistente (SAMR fue el germen más frecuentemente aislado (35.7%; la prevalencia de bacteriemia fue del 8.6%, en donde el germen más frecuente fue Streptoccocus Beta hemolítico, grupo G (33% del total de hemocultivos positivos. La bacteriemia se asoció significativamente a mayor estadía hospitalaria (10.5 ± 8.9 vs. 4.9 ± 6, p = 0.004. Se asoció con mayor riesgo de hemocultivo positivo a ser diabético, tener cultivo de PPB positivo, consumo de alcohol y/o enfermedad pulmonar obstructiva crónica.Cellulitis is an acute inflammation of dermis and subcutaneous tissue, usually complicating wounds, ulcers, or dermatosis. Even though in these cases it is recommended to perform culture from skin and soft tissue samples, the utility of blood cultures remains controversial due to the low frequency of positive results. Here we report the prevalence of bacteremia in patients with cellulitis admitted in our

  18. Juvenile cellulitis in a puppy – case reportsCelulite juvenil canina – relato de casos

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Fonseca-Alves

    2012-08-01

    Full Text Available Juvenile cellulitis or juvenile sterile granulomatous lymphadenitis is a rare disorder that affects puppies between three weeks to six months years old. Clinical signs include alopecia, edema, papules, pustules and crusts especially on eyelids. Definitive diagnosis requires cytological and histological evaluation and early and aggressive therapy is recommended, once scars after recovery can be severe .The choice treatment is the high dose of corticosteroids use such as prednisone. Three animals of canine species were attended at the Veterinary Hospital Clinical Small Animal Service presenting different clinical signs. Hemogram, skin lesions and submandibular lymph nodes cytological examination was collected and analyzed. The treatment was instituted, using cephalexin (22mg/kg, twice daily up to control of secondary bacterial infection, and prednisone (2mg/kg, once a day until clinical resolution. Complete cure was obtained at the end of treatment. The aim of this work is to report three clinical cases of juvenile cellulitis in dogs. A celulite juvenil ou linfadenite granulomatosa estéril juvenil, é um distúrbio raro que acomete filhotes com idade entre três semanas a seis meses. Os sinais clínicos incluem alopecia, edema, pápulas, pústulas e crostas especialmente em pálpebras. O diagnóstico definitivo requer exames citológico e histopatológico e a terapia precoce e agressiva é preconizada, pois as cicatrizes após recuperação podem ser graves. O tratamento de escolha consiste no uso de altas doses dos glicocorticoides, como prednisona. Foram atendidos no Hospital Veterinário, três animais da espécie canina, apresentando sinais clínicos variados. Foram realizados hemograma, exame citológico das lesões de pele e dos linfonodos submandibulares. O tratamento foi instituído, utilizando-se cefalexina na dose de 22 mg/kg, duas vezes ao dia, até controle de infecção bacteriana secundária e prednisona na dose de 2mg/kg, uma vez

  19. A case of cellulitis of the hands caused by a predatory bird attack

    Institute of Scientific and Technical Information of China (English)

    M Adil Abbas Khan; Mohammed Farid; Zain A Sobani; Syed Nadir Ali; Huzaifa Malick; Maryam Baqir; Hasanat Sharif; M Asim Beg

    2011-01-01

    Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  20. Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report

    Directory of Open Access Journals (Sweden)

    Probst Corina

    2010-08-01

    Full Text Available Abstract Background Cryptococcus neoformans is an encapsulated yeast and the most frequent cryptococcal species found in humans. Cryptococcosis is considered an opportunistic infection as it affects mainly immunosuppressed individuals. In humans, C. neoformans causes three types of infections: pulmonary cryptococcosis, cryptococcal meningitis and wound or cutaneous cryptococcosis. Case Presentation An 81-year-old woman developed severe necrotizing cellulitis on her left arm without any preceding injury. The patient had been treated with systemic corticosteroids over twenty years for rheumatoid arthritis (RA. Skin biopsies of the wound area were initially interpreted as cutaneous vasculitis of unknown etiology. However, periodic acid Schiff staining and smear analysis later revealed structures consistent with Cryptococcus neoformans, and the infection was subsequently confirmed by culture. After the initiation of therapy with fluconazole 400 mg per day the general condition and the skin ulcers improved rapidly and the patient was discharged to a rehabilitation facility. Subsequently surgical debridement and skin grafting were performed. Conclusions Opportunistic infections such as cryptococcosis can clinically and histologically mimic cutaneous vasculitis and have to be investigated rigorously as a differential diagnosis in immunosuppressed patients.

  1. A case of cellulitis of the hands caused by a predatory bird attack

    Directory of Open Access Journals (Sweden)

    M Adil Abbas Khan

    2011-04-01

    Full Text Available Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an 80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  2. Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis

    Science.gov (United States)

    Kong, Benjamin Y.; Chou, Shaun; Wakade, Deepal; Carlino, Matteo S.; Fernandez-Penas, Pablo

    2017-01-01

    There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and topical diphencyprone was applied to these metastases. Six weeks later, the patient developed fever and a spreading erythematous tender indurated plaque covering the left side of the body including axillae, back, and flank, clinically suggestive of cellulitis. Systemic antibiotic therapy did not improve the condition and a biopsy showed sparse lymphocytic infiltrate. With the diagnosis of possible acute lymphedema, a CT scan was requested that showed significant axillary lymph node metastasis. The fever was considered secondary to dabrafenib and trametinib therapy. This case highlights that, in patients with lymphadenectomy, atypical forms of lymphedema on the body may appear. Truncal lymphedema is an infrequent event. PMID:28182109

  3. Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.

    Science.gov (United States)

    Hau, Estelle; Bouaziz, Jean-David; Lafaurie, Matthieu; Saussine, Anne; Masson, Vincent; Rausky, Jonathan; Bagot, Martine; Guibal, Fabien

    2016-03-01

    Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.

  4. Peritonsillar abscess and cellulitis and their relation to a positive antigen detection test for streptococcal infection.

    Science.gov (United States)

    Risberg, Stefan; Engfeldt, Peter; Hugosson, Svante

    2010-10-01

    The microbiological cause of peritonsillar abscess and the role of group A β-haemolytic Streptococcus (GAS) are unclear. We performed a retrospective study at the ear, nose and throat clinic (ENT) of Orebro University Hospital, Sweden, and included 376 events of peritonsillitis between 2002 and 2004. We determined if the patients had visited a primary healthcare centre (PHCC) within 30 days prior to inclusion. The results of the rapid antigen detection test for GAS (Strep A) taken at the PHCC were compared with the occurrence of peritonsillar abscess (PTA) and peritonsillar cellulitis (PTC). A Strep A test was performed in 61% (229/376) of the events studied. Strep A was positive in 22% of PTA events and in 35% of PTC events (p = 0.036). Of 48,000 Strep A tests taken in primary healthcare, mainly for sore throat, 22% were positive. We examined the relationship between age, the incidence of PTA, and positive Strep A tests. We also determined if there was a monthly correlation between number of positive Strep A tests and number of PTA events. We found no significant correlations. In conclusion, our findings indicate that GAS does not play a major role in the development of PTA/PTC.

  5. Laser Capture Microdissection of Feline Streptomyces spp Pyogranulomatous Dermatitis and Cellulitis.

    Science.gov (United States)

    Traslavina, R P; Reilly, C M; Vasireddy, R; Samitz, E M; Stepnik, C T; Outerbridge, C; Affolter, V K; Byrne, B A; Lowenstine, L J; White, S D; Murphy, B

    2015-11-01

    Suspected Streptomyces spp infections were identified in 4 cats at UC Davis Veterinary Medical Teaching Hospital between 1982 and 2011. Three had ulcerated, dark red mycetomas involving the dermis, subcutis, and fascia with fistulous tracts and/or regional lymphadenopathy. One cat had pyogranulomatous mesenteric lymphadenitis. Granulomatous inflammation in all cats contained colonies of Gram-positive, non-acid-fast organisms. All 4 cats failed to respond to aggressive medical and surgical treatment and were euthanized. Laser capture microdissection (LCM) was used to selectively harvest DNA from the affected formalin-fixed, paraffin-embedded (FFPE) tissues. Cloned amplicons from LCM-derived tissue confirmed the presence of Streptomyces spp in the dermatitis cases. Amplicons from the remaining cat with peritoneal involvement aligned with the 16S ribosomal RNA gene for Actinomycetales. Usually considered a contaminant, Streptomyces spp can be associated with refractory pyogranulomatous dermatitis and cellulitis in cats with outdoor access. LCM is useful in the diagnosis of bacterial diseases where contamination may be an issue.

  6. Facial Candida albicans cellulitis occurring in a patient with oral submucous fibrosis and unknown diabetes mellitus after local corticosteroid injection treatment.

    Science.gov (United States)

    Chen, Hsin-Ming; Shih, Chiang-Ching; Yen, K Lawrence; Wang, Sheng-Ming; Kuo, Ying-Shiung; Kuo, Mark Yen-Ping; Chiang, Chun-Pin

    2004-04-01

    Facial cellulitis caused by odontogenic bacterial infection is frequently encountered; however, facial cellulitis caused by Candida albicans infection is rarely found. A patient with oral submucous fibrosis (OSF) and unknown diabetes mellitus (DM) was treated in our out-patient dental clinic by biweekly submucosal injection of 40 mg triamcinolone acetonide into bilateral buccal mucosae plus forced mouth opening performed by the two hands of the clinician. The interincisal distance of the patient improved from 28 to 48 mm after four times of steroid injection. The symptoms and signs of OSF also improved markedly. Unfortunately, facial candidal cellulitis occurred 2 months after the last time of steroid injection treatment. The infection was cured by incision and drainage, intravenous administration of amphotericin B (100 mg once a day for a week), and an appropriate medical control of DM. No recurrence of facial cellulitis was found during the follow-up period of 18 months. To prevent the occurrence of facial cellulitis after a high-dose steroid therapy, some prophylactic procedures should be taken before the initiation of the steroid treatment.

  7. Implications and applications of systematic reviews for evidence-based dentistry and comparative effectiveness research: A sample study on antibiotics for oro-facial cellulitis treatment

    Directory of Open Access Journals (Sweden)

    Quyen Bach

    2015-01-01

    Full Text Available Introduction: Comparative effectiveness and efficacy research for analysis and practice (CEERAP was performed to assess the effects of penicillin-based versus erythromycin-based antibiotic treatments in patients with skin and soft tissue infections (SSTIs including cellulitis, impetigo, and erysipelas. Because SSTIs, especially orofacial cellulitis, are volatile infectious diseases of a life-threatening nature, research on the most efficacious remedies is necessary. Methods: The stringent bibliome yielded three systematic reviews, which were examined for quality of research synthesis protocol and clinical relevance. Results: The sample size of three, rendered the statistical analyses and cumulative meta-analysis problematic. Conclusion: The systematic review outlined here should aid in increasing clinical awareness, improving patient health literacy, and promoting consensus of the best evidence base (BEB to mitigate the threat of sepsis and potential death caused by cellulitis infections.

  8. [Infectious cellulitis of the face complicating injection for esthetic nasolabial sulcus by hyaluronic acid: report of seven cases].

    Science.gov (United States)

    Chader, H; Bosc, R; Hersant, B; Lange, F; Hermeziu, O; Zehou, O; Chosidow, O; Meningaud, J-P

    2013-12-01

    We report a case series of seven patients with bacterial cellulitis of the face complicating a filler injection for cosmetic reason, treated in a university hospital from 2005 to 2012. There were seven women aged 34 to 57 years. Two patients had a deep collection requiring surgical excision combined with antibiotics. Five patients were treated with antibiotics only. In two cases the bacteria was found streptococcus A and in one case Staphylococcus aureus. One patient required hospitalization in an intensive care unit. Only patients who needed surgical treatment showed moderate aesthetic sequelae.

  9. Ultrahigh-rate supercapacitors with large capacitance based on edge oriented graphene coated carbonized cellulous paper as flexible freestanding electrodes

    Science.gov (United States)

    Ren, Guofeng; Li, Shiqi; Fan, Zhao-Xia; Hoque, Md Nadim Ferdous; Fan, Zhaoyang

    2016-09-01

    Large-capacitance and ultrahigh-rate electrochemical supercapacitors (UECs) with frequency response up to kilohertz (kHz) range are reported using light, thin, and flexible freestanding electrodes. The electrode is formed by perpendicularly edge oriented multilayer graphene/thin-graphite (EOG) sheets grown radially around individual fibers in carbonized cellulous paper (CCP), with cellulous carbonization and EOG deposition implemented in one step. The resulted ∼10 μm thick EOG/CCP electrode is light and flexible. The oriented porous structure of EOG with large surface area, in conjunction with high conductivity of the electrode, ensures ultrahigh-rate performance of the fabricated cells, with large areal capacitance of 0.59 mF cm-2 and 0.53 mF cm-2 and large phase angle of -83° and -80° at 120 Hz and 1 kHz, respectively. Particularly, the hierarchical EOG/CCP sheet structure allows multiple sheets stacked together for thick electrodes with almost linearly increased areal capacitance while maintaining the volumetric capacitance nearly no degradation, a critical merit for developing practical faraday-scale UECs. 3-layers of EOG/CCP electrode achieved an areal capacitance of 1.5 mF cm-2 and 1.4 mF cm-2 at 120 Hz and 1 kHz, respectively. This demonstration moves a step closer to the goal of bridging the frequency/capacitance gap between supercapacitors and electrolytic capacitors.

  10. Submandibular cellulitis (Ludwig's angina) associated to a complex odontoma erupted into the oral cavity. Case report and literature review.

    Science.gov (United States)

    Bertolai, R; Acocella, A; Sacco, R; Agostini, T

    2007-01-01

    The clinical presentation of Ludwig's angina consists in a severe expanding cellulitis causing swelling of the floor of the mouth, tongue and submandibular region, thus resulting in a possible obstruction of the airway and in a rapid progress in deep neck soft tissue infection and mediastinitis with potentially fatal consequences. Frequently, submandibular cellulitis develops from an acute infection spreading from the lower molar teeth. Mandibular fractures, traumatic laceration of the floor of the mouth, and peritonsillar abscesses are other concomitant clinical features. A case of Ludwig's angina associated with a large erupted odontoma and with a deeply impacted third molar displaced to the border of the mandible is described. The patient was affected by enlargement of submandibular space, marked face swelling causing an evident face deformity, tenderness and redness of the neck and limited movement of the neck and mouth. In the past, Ludwig's angina was frequently fatal, however aggressive surgical and medical therapy have significantly reduced the mortality rate. The reported case can be considered as important, not only because of the rarity of the odontoma eruption in the oral cavity, but mainly for the extent of the clinical manifestation of a lesion usually described in literature as asymptomatic.

  11. Non-suppurative cellulitis: risk factors and its association with Staphylococcus aureus colonization in an area of endemic community-associated methicillin-resistant S. aureus infections.

    Science.gov (United States)

    Eells, S J; Chira, S; David, C G; Craft, N; Miller, L G

    2011-04-01

    Suppurative methicillin-resistant Staphylococcus aureus (MRSA) skin infections are common and associated with MRSA colonization, but little is known about non-suppurative cellulitis and its relationship with MRSA colonization in areas endemic for community-associated MRSA. We prospectively enrolled patients hospitalized for non-suppurative cellulitis (n=50) and matched controls (n=100) and found S. aureus colonization was similar in cases and controls (30% vs. 25%, P=0·95). MRSA was uncommon in cases (6%) and controls (3%) (P=0·39). All MRSA isolates were USA300 by pulsed-field gel electrophoresis. Independent risk factors for non-suppurative cellulitis were diabetes (OR 3·5, 95% CI 1·4-8·9, P=0·01) and homelessness in the previous year (OR 6·4, 95% CI 1·9-20·9, P=0·002). These findings suggest that MRSA may only rarely be causative of non-suppurative cellulitis.

  12. Etude théorique des cellules solaires PV organiques: structure réseau interpénétré polymère conjugué-fullerène et cellules Graetzel

    OpenAIRE

    Zakaria, BOUZID

    2014-01-01

    Le photovoltaïque est aujourd'hui une technologie d'énergie renouvelable en plein essor. La croissance du marché a été comprise entre 15% et 20% durant la dernière décennie. Malgré le développement des matériaux et des méthodes de fabrication fortement soutenus par la croissance de l'industrie des semi-conducteurs, le coût des cellules solaires est resté élevé. Cependant, de nouveaux matériaux photovoltaïques ont été développés durant les dernières années, cela pourrait bien ouvri...

  13. Early Differential Diagnosis of Rhino-Orbito-Cerebral Mucormycosis and Bacterial Orbital Cellulitis: Based on Computed Tomography Findings

    Science.gov (United States)

    Son, Jun Hyuk; Lim, Hyung Bin; Lee, Soo Hyun; Yang, Jae Wook; Lee, Sung Bok

    2016-01-01

    Purpose To identify significant clinical and radiological findings that distinguish rhino-orbito-cerebral mucormycosis (ROCM) from bacterial orbital cellulitis (BOC). Methods This study was retrospective, multicenter, case-control study that enrolled 34 cases; 14 cases were diagnosed with ROCM and 20 cases were diagnosed with BOC at three different tertiary hospitals between 2005 and 2013. The medical records of all 34 cases were reviewed. The initial clinical manifestations (eyelid swelling, ptosis, extraocular muscle [EOM] limitation, conjunctival injection, and chemosis) and computed tomography (CT) findings (sinus mucosal thickening, full opacification, and air-fluid level) of both diseases were compared. Results Patients with diabetes mellitus (DM) and hypertension (HTN) showed higher incidence rates of ROCM than BOC (DM: p < 0.001, HTN: p = 0.036). ROCM cases exhibited more frequent EOM limitation than cases with BOC (100.0% vs. 66.7%, p = 0.024) but less frequent eyelid swelling (35.7% vs. 90.0%, p = 0.002). However, the incidence rates of ptosis, conjunctival injection, and chemosis exhibited no differences between the diseases. Abnormal CT findings were observed in the sinuses of all patients with ROCM, whereas 12 patients with BOC had sinus abnormalities (100.0% vs. 60.0%, p = 0.011). Thickening of the sinus mucosa was more frequent in patients with ROCM than in those with BOC (92.9% vs. 45.0%, p = 0.009). No significant differences in full opacification or air-fluid level were detected between the groups. Conclusions The differential diagnosis of ROCM and BOC is difficult. Nevertheless, physicians should consider ROCM when a patient with suspected orbital cellulitis presents with EOM limitation without swollen eyelids or thickening of the sinus mucosa on a CT scan. PMID:27501044

  14. Cancer bronchique à petites cellules et grossesse: à propos d'un cas avec revue de la literature

    Science.gov (United States)

    Safini, Fatima; Jjouhadi, Hassan; Chehal, Asmaa; Mernissi, Farida; Wilfried, Akpoo; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2016-01-01

    Le cancer broncho-pulmonaire (CBP) de la femme enceinte est une entité rare, d’évolution péjorative. Cette situation devient de plus en plus fréquente, du fait de l'augmentation du tabagisme chez la femme. La transmission tumorale trans-placentaire avec atteinte fœtale est décrite surtout chez les femmes non traitées. Le traitement est multidisciplinaire et n'est pas bien codifié. Nous rapportons le cas d'une patiente de 23 ans chez qui le diagnostic d'un carcinome bronchique à petites cellules a été fait au cours de sa grossesse. Elle avait bénéficié d'une chimiothérapie pendant la grossesse, bien tolérée. L’évaluation radiologique a objectivé une stabilisation du processus pulmonaire. Le traitement a été complété par une association radio-chimiothérapie concomitante après l'accouchement. PMID:27279957

  15. Nasal Type Extranodal Natural Killer/T (NK/T) Cell Lymphoma Presenting as Periorbital Cellulitis: A Case Report

    Science.gov (United States)

    Shawabkeh, Ma’in Ali Al; Sulaiti, Mansour Al; Sa’ey, Hamad Al; Ganesan, Shanmugam

    2016-01-01

    Patient: Male, 25 Final Diagnosis: Nasal type • extra nodal NK/T-cell lymphoma Symptoms: Left periorbital swelling • redness • pain for 25 days • yellowish eye discharge associated • headache • fever Medication: — Clinical Procedure: — Specialty: Otolaryngology Objective: Unusual clinical course Background: Extranodal lymphoma of the paranasal sinuses is a rare clinical entity seen in only 5–8% of extranodal lymphomas of the head and neck. Nasal natural killer/T cell lymphoma (Nasal NKTCL), which is a subtype of peripheral T cell lymphoma, constitutes about 1.4% of all lymphomas. NKTCL is usually diagnosed at a late stage because it presents with nonspecific symptoms in the early stages. Case Report: We report the case of a 25-year-old male patient who presented with periorbital swelling treated as fungal sinusitis but proven to have NKTCL. We review the literature and discuss the clinical manifestations of the disease, its relation to EBV virus, the histological and radiological characteristics, the prognostic indicators, and treatment options. This case report shows physicians that NKTCL lymphoma can present as periorbital cellulitis, although few similar cases are found in the literature. Conclusions: NKTCL is a destructive midline tumor that should be kept in mind as a differential diagnosis of paranasal sinus lesions to help in early diagnosis, which can improve the prognosis. PMID:27932776

  16. Analysis of sixty-three cases of orbital cellulitis%眶蜂窝织炎63例分析

    Institute of Scientific and Technical Information of China (English)

    杜军辉; 王雨生; 李夏; 郭长梅; 李曼红

    2010-01-01

    目的 探讨眶蜂窝织炎的致病原因、致病菌及并发症.方法 回顾性病例系列研究.回顾性分析西京医院自1960年至2008年收治的63例眶蜂窝织炎住院患者的临床资料,对其性别、年龄、致病途径、致病菌及并发症进行分析.结果 63例患者中,男性48例(76.2%),女性15例(23.8%);10岁以下年龄组患者较多(22例,34.9%);单眼发病多见(61例,96.8%);32例(50.8%)患者伴有明显眼球突出.致病途径以周围组织炎症蔓延最多见(47.6%),其他包括血行感染(19.0%)、眼部外伤(15.9%)和眼部手术后并发感染(3.2%).30例患者进行了细菌培养,仅18例(60.0%)细菌培养为阳性.致病菌有4类,以葡萄球菌属最为多见(14例,77.8%),尤以金黄色葡萄球菌为主(8例,44.4%),此外还有绿脓杆菌(11.1%)、甲型溶血性链球菌(5.6%)和中间型弗氏枸橼酸杆菌(5.6%).本组有19例(30.1%)发生并发症,包括败血症(12.7%)、暴露性角膜炎(4.8%)、全眼球炎(4.8%)、化脓性脑膜炎(4.8%)和海绵窦栓塞性静脉炎(3.2%)等.结论 眶蜂窝织炎多见于10岁以下儿童患者,以单眼眼球突出为主要表现,致病途径以眶周组织结构感染蔓延为主.细菌培养阳性率较低,以金黄色葡萄球菌为主要致病菌.本病可发生严重并发症,宜早期积极给予广谱抗生素治疗,如脓肿形成应及时切开引流.%Objective To investigate the clinical characteristics, etiological factors and pathogenic bacterium of orbital cellulitis. Methods A retrospective clinical study was done on 63 orbital cellulitis patients receiving treatments in Xijing Hospital between 1960 to 2008, and their gender, age, pathogenic approach, pathogens and complications were analyzed. Results Of the 63 patients, 76.2% were males and 23.8% were females. The highest incidence occurred in the 0-10 year old group (34.9%). There were 96.8% of the patients suffered unilateral eye injures, 50.8% of the patients expressed obvious exophthalmos

  17. Quantification des cellules viables de P. phosphoreum dans les pavés de saumon cru par PCR temps reel

    DEFF Research Database (Denmark)

    Macé, Sabine; Mamlouk, Kelthoum; Chipchakova, Stoyka

    ’altération. Par conséquent, nous avons développé une méthode de PCR temps réel spécifique combinée avec une étape de traitement au PMA pour quantifier les cellules viable de P.phosphoreum dans le saumon cru conditionné sous atmosphère modifiée. Les amorces spécifiques ont été dessinées pour amplifier un fragment...... obtenue en comparaison avec des résultats de numération sur milieu Marine Agar. Sur saumons artificiellement contaminés, la quantification par PCR temps réel est linéaire sur 5 Log. Sur les produits naturellement contaminés, la méthode fonctionne avec succès avec un seuil minimum de 3 Log (UFC/g) pour une...... quantification précise. La précision de cette méthode a également été évaluée en la comparant avec une méthode déjà existence de quantification par conductancemétrie. Les données obtenues sur 22 échantillons montrent une très bonne corrélation (R2 de 0.94) entre les résultats des 2 méthodes. Ce travail a donné...

  18. Dissecting cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): a comprehensive review focusing on new treatments and findings of the last decade with commentary comparing the therapies and causes of dissecting cellulitis to hidradenitis suppurativa.

    Science.gov (United States)

    Scheinfeld, Noah

    2014-05-16

    Dissecting cellulitis (DC) also referred to as to as perifolliculitis capitis abscedens et suffodiens (Hoffman) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. In the U.S., it predominantly occurs in African American men between 20-40 years of age. DC also occurs in other races and women more rarely. DC has been reported worldwide. Older therapies reported effective include: low dose oral zinc, isotretinoin, minocycline, sulfa drugs, tetracycline, prednisone, intralesional triamcinolone, incision and drainage, dapsone, antiandrogens (in women), topical clindamycin, topical isotretinoin, X-ray epilation and ablation, ablative C02 lasers, hair removal lasers (800nm and 694nm), and surgical excision. Newer treatments reported include tumor necrosis factor blockers (TNFB), quinolones, macrolide antibiotics, rifampin, alitretinoin, metronidazole, and high dose zinc sulphate (135-220 mg TID). Isotretinoin seems to provide the best chance at remission, but the number of reports is small, dosing schedules variable, and the long term follow up beyond a year is negligible; treatment failures have been reported. TNFB can succeed when isotretinoin fails, either as monotherapy, or as a bridge to aggressive surgical treatment, but long term data is lacking. Non-medical therapies noted in the last decade include: the 1064 nm laser, ALA-PDT, and modern external beam radiation therapy. Studies that span more than 1 year are lacking. Newer pathologic hair findings include: pigmented casts, black dots, and "3D" yellow dots. Newer associations include: keratitis-ichthyosis-deafness syndrome, Crohn disease and pyoderma gangrenosum. Older associations include arthritis and keratitis. DC is likely a reaction pattern, as is shown by its varied therapeutic successes and failures. The etiology of DC remains enigmatic and DC is distinct from hidradenitis suppurativa, which is shown by their varied responses to therapies and their

  19. Primary cellulitis and cutaneous abscess caused by Yersinia enterocolitica in an immunocompetent host: A case report and literature review.

    Science.gov (United States)

    Kato, Hirofumi; Sasaki, Shugo; Sekiya, Noritaka

    2016-06-01

    Primary extraintestinal complications caused by Yersinia enterocolitica are extremely rare, especially in the form of skin and soft-tissue manifestations, and little is known about their clinical characteristics and treatments. We presented our case and reviewed past cases of primary skin and soft-tissue infections caused by Y enterocolitica. We report a case of primary cellulitis and cutaneous abscess caused by Y enterocolitica in an immunocompetent 70-year-old woman with keratodermia tylodes palmaris progressiva. She presented to an outpatient clinic with redness, swelling, and pain of the left ring finger and left upper arm without fever or gastrointestinal symptoms 3 days before admission. One day later, ulceration of the skin with exposed bone of the proximal interphalangeal joint of the left ring finger developed, and cefditoren pivoxil was described. However, she was admitted to our hospital due to deterioration of symptoms involving the left finger and upper arm. Cefazolin was initiated on admission, then changed to sulbactam/ampicillin and vancomycin with debridement of the left ring finger and drainage of the left upper arm abscess. Wound culture grew Y enterocolitica serotype O:8 and methicillin-sensitive Staphylococcus aureus. Blood cultures were negative and osteomyelitis was ruled out. Vancomycin was switched to ciprofloxacin, then skin and soft-tissue manifestations showed clear improvement within a few days. The patient received 14 days of ciprofloxacin and oral amoxicillin/clavulanate and has since shown no recurrence. We reviewed 12 cases of primary skin and soft-tissue infections caused by Y enterocolitica from the literature. In several past cases, portal entry involved failure of the skin barrier on distal body parts. Thereafter, infection might have spread to the regional lymph nodes from the ruptured skin. Y enterocolitica is typically resistant to aminopenicillins and narrow-spectrum cephalosporins. In most cases, these inefficient

  20. Perianal streptococcal cellulitis

    Science.gov (United States)

    Complications that may result include: Anal scarring, fistula , or abscess Bleeding, discharge Bloodstream or other streptococcal infections (including heart, joint, and bone) Kidney disease (acute glomerulonephritis ) Severe skin and soft tissue ...

  1. What Is Cellulitis?

    Science.gov (United States)

    ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ...

  2. Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

    Directory of Open Access Journals (Sweden)

    Ledina Dragan

    2012-11-01

    Full Text Available Abstract Introduction Campylobacter is an important causative agent of intestinal infections in humans. Bacteremia is detected in less than 1% of patients, mainly in immunocompromised patients and in extreme age groups. Cellulitis is a relatively common manifestation of Campylobacter infection, but concomitant bacteremia is a rare event. Infections of the pacemaker area are caused primarily by staphylococci, followed by fungi, streptococci and Gram-negative rods. To the best of our knowledge, this is the first case report of pacemaker pocket infection and bacteremia caused by Campylobacter fetus. Case presentation A 72-year-old Croatian Caucasian man with myelodysplasia, impaired fasting glucose levels and a recently implanted permanent pacemaker was admitted to hospital after six days of fever, development of red swelling of the pacemaker pocket area and worsening of his general condition. No antibiotic therapy was introduced in the outpatient setting. He denied any recent gastrointestinal disturbances. With the exception of an elevated leukocyte count, erythrocyte sedimentation rate, and C-reactive protein and blood glucose levels, other laboratory findings were normal. Treatment with vancomycin plus netilmicin was introduced, and a surgical incision with drainage of the pacemaker pocket was performed. The entire pacemaker system was removed and a new one re-implanted after 14 days of antibiotic therapy. Transesophageal echocardiography showed no pathological findings. Three subsequent blood cultures obtained on admission as well as swab culture of the incised pacemaker area revealed Campylobacter fetus; stool and pacemaker lead cultures were negative. According to the microbiological results, antibiotic therapy was changed to ciprofloxacin plus netilmicin. A clinical examination and the results of a laboratory analysis performed after two weeks of therapy were within normal limits. Conclusion Myelodysplasia, impaired fasting glucose levels

  3. Etude des phenomenes chimiques au contact entre le bloc cathodique et la barre collectrice d'une cellule d'electrolyse d'aluminium

    Science.gov (United States)

    Lebeuf, Martin

    La production d'aluminium est une industrie importante au Québec. Les propriétés de ce métal le vouent à de multiples usages présents et futurs dans le cadre d'une économie moderne durable. Toutefois, le procédé Hall-Héroult est très énergivore et des progrès demeurent donc nécessaires pour en diminuer les coûts financiers et environnementaux. Parmi les améliorations envisageables de la cellule d'électrolyse se trouve le contact entre la cathode et la barre collectrice, qui doit offrir une faible résistivité au passage du courant électrique. En cours d'opération de la cellule, ce contact a tendance à se dégrader, générant des pertes énergétiques significatives. Les causes de cette dégradation, pouvant provenir de phénomènes chimiques, thermiques, mécaniques et/ou électriques, demeurent mal comprises. Le but du présent projet était donc d'étudier les phénomènes chimiques se produisant au contact bloc-barre de la cellule d'électrolyse Hall-Héroult. En premier lieu, un aspect crucial à considérer est la pénétration du bain électrolytique dans la cathode, car des composés de bain atteignent éventuellement la barre collectrice et peuvent y réagir. A cet effet, une méthode novatrice a été développée afin d'étudier les cathodes et la pénétration du bain dans celles-ci à l'aide de la microtomographie à rayons X. Cette méthode rapide et efficace s'est avérée fort utile dans le projet et a un potentiel important pour l'étude future des cathodes et des phénomènes qui s'y produisent. Ensuite, une cellule d'électrolyse rectangulaire à petite échelle a été développée. Plusieurs phénomènes observés 'en industrie sur des autopsies de cellules post-opération et rapportés dans la littérature ont été reproduis avec succès à l'aide de cette cellule expérimentale. Puis, des tests sans électrolyse, ciblant l'effet du bain électrolytique sur l'acier, ont aussi été conçus et complétés afin de s

  4. M(E)CANISMES MOL(E)CULAIRES IMPLIQU(E)S DANS L'ALT(E)RATION DU PH(E)NOTYPE DES CELLULES (E)PITHELIAL(E)S TUBULAIRES PAR LES CALPA(I)NES EXTRACELLULAIRES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wen-hui; Joelle Perez; Laurent Baud

    2008-01-01

    Objectif Rechercher les mécanismes moléculaires par lesquels des calpaines extracellulaires af-fectent l'adhérence et la mobilité des cellules épithéliales HK-2 dérivées du tubule proximal humain. Méthodes Western blot pour détecter le clivage des chaines α des intégrines; dosage radioimmunologique pour mesurer l' AMP cyclique intracellulaire; fluorescence-activated cell sorting (FACS) pour tester l' apoptose cellulaire. La morpholo-gie des cellules HK-2 a été observée et photographiée. Résultats (1) L ' exposition des cellules HK-2 à la calpaine μ n'a pas entrainé de clivage des chaines o3 et αV des intégrines; (2)l' exposition des cellules HK-2 à la calpaine μ entrainait une augmentation progressive de l' accumulation intracellulaire d' AMP cyclique (P<0.05) qui était associée une résistance cellulaire à l'apoptose(P <0. 05 ) ; (3)l'addition d'un inhibiteur pharmacologique de la protéine kinase A(PKA) prévenait totalement les modifications d'adhérence et de mobilité cellulaires induites par calpaine μ Conclusion Les calpaines externalisées peuvent modifier l' adherence et la mobilité cellulaires via un mécanisme qui implique l'accumulation d' AMP cyclique et l' activation de la PKA. Par ces mécanismes, les calpaines externalisées pourraient jouer un role dans l'induction de la réparation au cours de l'insuffucance rénale aiguё.

  5. Prediction of Instability for Miscible Displacements in a Hele-Shaw Cell Prévision de l'instabilité pour des déplacements miscibles dans une cellule Hele-Shaw

    Directory of Open Access Journals (Sweden)

    Coskuner G.

    2006-11-01

    Full Text Available A universal dimensionless scaling group and its critical value at the onset of instability for a miscible displacement in a Hele-Shaw cell is derived. The derivation is based on a variational technique and it is capable of considering, for the first time, the effect of the length of a Hele-Shaw cell on the criterion for the onset of instability. The theory is verified by comparing it with forty-four Hele-Shaw cell experiments. On calcule un groupe universel sans dimension de mise à l'échelle et sa valeur critique au départ de l'instabilité dans un déplacement miscible dans une cellule Hele-Shaw. Ce calcul est basé sur une technique variationnelle et permet, pour la première fois, de prendre en compte l'effet de la longueur d'une cellule Hele-Shaw sur le critère d'apparition d'instabilité. La théorie est vérifiée en la comparant avec des expériences réalisées avec quarante-quatre cellules Hele-Shaw.

  6. Régulation de la production, par des cellules endothéliales, de cytokines pro-inflammatoires après irradiation

    Science.gov (United States)

    van der Meeren, A.; Lafont, H.; Mathé, D.

    1998-04-01

    Gamma irradiation leads to an increased production of interleukin- (IL)-6 and IL-8 by human endothelial cells. In order to regulate the radio-induced production of these pro-inflammatory cytokines, we used the immunoregulatory cytokines IL-4 and IL-10. These agents were added either before or after a 10 Gy-irradiation. Our results show that it is possible to decrease the radio-induced production of IL-6 and IL-8 with the use of IL-4 and IL-10. Differences in the intensity of the response have been observed according to the time of treatment. The anti-inflammatory potential of both IL-4 and IL-10 was more pronounced when added after irradiation. Après irradiation gamma, des cellules endothéliales humaines ont une production accrue des interleukines (IL-) -6 et -8. Dans le but de réguler la production de ces cytokines pro-inflammatoires, nous avons utilisé des cytokines dites anti-inflammatoires, l'IL-4 et l'IL-10. Ces agents ont été ajoutés soit avant soit après une irradiation de 10Gy. Nos résultats montrent qu'il est possible de diminuer les productions radio-induites d'IL-6 et d'IL-8 par l'IL-4 et l'IL-10. Des différences dans l'intensité de la réponse ont toutefois été observées selon que l'IL-4 ou l'IL-10 ont été ajoutées avant ou après irradiation; leur efficacité anti-inflammatoire étant plus marquée lorsque les cytokines sont ajoutées après l'irradiation.

  7. Oral and Maxillofacial Infection Misdiagnosed as Facial Cellulitis:Report of 1 Cases%口腔颌面部感染误诊为鼻面部蜂窝组织炎1例

    Institute of Scientific and Technical Information of China (English)

    王爱平; 孙海波

    2014-01-01

    本文通过鼻面部肿痛应为左上颌中切牙急性化脓性尖周炎引起的眶下间隙急性化脓性感染的病例对口腔颌面部感染误诊为鼻面部蜂窝组织炎的病例进行阐述。%The cases of acute suppurative infection clearance through nasal and facial swel ing caused by left maxil ary central incisors should for acute suppurative periapical infection infraorbital carries on the elaboration to the oral and maxil ofacial infection misdiagnosed as facial cellulitis case.

  8. Glycosphingolipides et fusion virus-cellule : données actuelles montrant le rôle des micro-domaines membranaires dans le cycle d’infection du VIH-1

    Directory of Open Access Journals (Sweden)

    Hammache Djilali

    2000-09-01

    Full Text Available Depuis plusieurs années, nous étudions les mécanismes moléculaires responsables de la fusion du virus de l’immunodéficience humaine (VIH avec la membrane plasmique des cellules cibles. Ces travaux ont permis de préciser le rôle essentiel joué par les micro-domaines de glycosphingolipides au cours de la fusion virus-cellule. En particulier, nous avons pu reconstituer un complexe de fusion fonctionnel faisant intervenir les différents partenaires moléculaires de la fusion : un micro-domaine de glycosphingolipide se présentant sous la forme d’un film monomoléculaire à l’interface eau-air, le récepteur CD4 et la glycoprotéine externe de l’enveloppe du virus, la gp120. La dynamique des interactions moléculaires dans ce complexe de fusion a pu être mesurée à l’aide d’un micro-tensiomètre. Ce système expérimental pourrait permettre d’évaluer l’activité d’inhibiteurs de fusion tels que des analogues synthétiques de glycosphingolipides.

  9. 口腔颌面部蜂窝织炎临床特点及治疗探讨%Clinical characteristics and investigation of treatment of oral and maxillofacial cellulitis

    Institute of Scientific and Technical Information of China (English)

    赵琼

    2014-01-01

    Objective:To explore the clinical characteristics and treatment of oral and maxillofacial cellulitis.Methods:50 patients with oral and maxillofacial cellulitis were selected.We developed a standard treatment plan for each patient according to the characteristics.Results:In 50 patients of this group,49 cases(98%) were cured,1 case was invalid and transferred to other hospital. The average course of disease was 15.8±2.1 days;among them,the course of disease of patients complicated with diabetic patients was relatively longer,some were more than one month.Conclusion:Early attention and diagnosis and treatment,anti-infection,local incision drainage and operation according to the clinical characteristics of oral and maxillofacial cellulitis,can significantly improve the prognosis,and it is very important to improve the quality of life of patients.%目的:探讨口腔颌面部蜂窝织炎临床特点及治疗。方法:收治口腔颌面部蜂窝织炎患者50例作为研究对象,依据临床特点,制定规范方案治疗。结果:本组50例患者,治愈49例(98%),无效转院1例,平均病程(15.8±2.1)天,其中有糖尿病合并者病程相对较长,部分超过1个月。结论:针对口腔颌面部蜂窝织炎,依据临床特点,早重视及诊治,行抗感染、局部切开引流及手术等,可明显改善预后,对提高患者生存质量有非常重要的意义。

  10. Estudo clínico de celulite orbitária e pré-septal na infância Orbital and preseptal cellulitis in childhood: a clinical study

    Directory of Open Access Journals (Sweden)

    César Moreira Sampaio

    2001-06-01

    Full Text Available Objetivo: Estudar retrospectivamente aspectos clínicos e terapêuticos em crianças portadoras de celulite orbitária e pré-septal. Métodos: Foram analisados 52 prontuários de pacientes com idades variando de um mês a doze anos, internados no período compreendido entre 1990 e 1998, com quadro de celulite orbitária ou pré-septal. Resultados: Trauma foi o fator predisponente mais freqüente das celulites orbitárias e pré-septais na infância, seguido pela sinusite e causas não-definidas. As infecções, na grande maioria, tiveram localização pré-septal (94,2%. As hemoculturas, realizadas em 21 pacientes, resultaram em 71% de negatividade, seguido por positividade para S. aureus (19%, H. influenzae (4,7% e flora mista (4,7%. Todos os pacientes foram tratados e curados com antibioticoterapia utilizando 16 quimioterápicos em 25 diferentes esquemas terapêuticos. A drenagem cirúrgica foi realizada em apenas 7 pacientes. Conclusão: A despeito da falta de uniformidade e diversidade de esquemas terapêuticos empregados nos casos estudados e da falta de avaliação oftalmológica na maioria dos casos, os pacientes foram curados sem complicações. Tal fato indica a necessidade de estudos prospectivos que visem a elaboração de protocolo terapêutico para as celulites da região orbitária na infância, que leve em consideração a relação custo-benefício positiva.Purpose: Retrospective study of clinical and therapeutic aspects in children with orbital and preseptal cellulitis. Methods: Fifty-two records of patients admitted at the São Rafael Hospital between 1990 and 1998 were reviewed. The age of the patients ranged from one month to twelve years. Based on a protocol elaborated by the authors the following aspects were analyzed: age, sex, predisposing factors, localization of the cellulitis in the orbital region, clinical, laboratorial and image findings as well as the clinical or surgical therapy and the occurrence of complications

  11. Clinical analysis of endoscopic surgery for rhinogenous orbital cellulitis%鼻源性眶蜂窝织炎鼻内镜手术治疗临床研究

    Institute of Scientific and Technical Information of China (English)

    周昆; 刘玥; 王佳; 贾明辉

    2015-01-01

    目的 探讨鼻内镜在鼻窦源性眶蜂窝织炎治疗中的应用效果.方法 鼻窦源性眶蜂窝织炎14例.将继发于上呼吸道感染的急性鼻窦炎归于急性组(9例),将慢性鼻窦炎急性发作归于慢性组(5例).两组患者均进行经鼻窦的鼻内镜下手术,观察其疗效.结果 经鼻内镜下手术及敏感抗生素应用等综合治疗,两组患者均痊愈,未发现严重影响视力及全身健康的并发症.结论 鼻内镜下手术治疗鼻窦源性眶蜂窝织炎具有视野清晰、径路便利、损伤小、恢复快及无面部瘢痕等优势.%Objective To evaluate the clinical effect of endoscopic surgery for the treatment of rhinogenous orbital cellulitis.Methods Fourteen cases of rhinogenous orbital cellulitis were treated by endoscopic surgery via nasal sinus.The curative effect of the surgery and postoperative complications were recorded and analyzed.Results After endoscopic surgery combined with systemic antibiotics,all patients were cured and no serious complication was observed.Conclusion Compared with the traditional surgery,endoscopic surgery possessed more advantages for the treatment of rhinogenous orbital cellalitis,such as clear field,convenient surgical route,less bleeding,no facial scar,quick recovery and good effect.

  12. Contribution to the radiological study of the eosinophilic granuloma of the mandible (Unifocal granuloma due to Langherans' cell histiocytosis); Contributo allo studio radiologico del granuloma eosinofilo della mandibola (granuloma unifocale da istiocitosi delle cellule di Lagherhans)

    Energy Technology Data Exchange (ETDEWEB)

    Chigi, Gino; Pastremoli, Alessandro; Pisi, Paolo; Pastremoli, Alfredo [Bologna Univ., Bologna (Italy). Dipartimento di scienze odontomastologiche; Bianchi, Giuseppe [Istituti Ortopedici Rizzoli, Bologna (Italy)

    2005-04-01

    non completamente risolto per talune condizioni patologiche, nelle quali i dati obiettivi ed anamnestici sono relativamente uniformi e il quadro radiologico privo di qualsiasi caratteristica. Materiale e metodi: Il materiale � costituito da sei casi di istiocitosi delle cellule di Langherans della mandibola osservati nell'arco di un decennio. Lo studio � basato sulla valutazione della documentazione radiologica tradizionale. Le radiografie sono state eseguite in proiezione latero-laterale-obliqua che, come noto, libera quasi completamente la porzione orizzontale della mandibola dalla sovrapposizione delle immagini di altre strutture ossee. Risultati: I risultati delle indagini radiologiche sono riportati nella tabella I. Si tratta di reticoloendoteliopatie capaci di dar luogo ad un processo granulomatoso costituito da polinucleati eosinofili, plasmacellule e linfociti e, fondamentalmente, da grandi cellule istiocitarie mononucleate dotate di attivit� granulopessica e fagocitaria, spiccatamente proliferanti nel tessuto osseo, identificabili con le cellule di Langherhans della pelle, delle mucose, degli spazi periodontali, del midollo osseo. Il tessuto granulomatoso che ne deriva si infiltra tra gli elementi costitutivi dell'organo colpito ed estendendosi comprime, atrofizza e tende a distruggere il tessuto, sostituendosi ad esso. Le alterazioni determinate dal granuloma isiocitario di Langherhans prevalgono nettamente nel sistema scheletrico e si verificano, in ordine di frequenza, nel cranio, nelle ossa lunghe dell'estremit�, nel piede, nelle coste e nella colonna vertebrale. L'interessamento della mucosa orale � eccezionale. Conclusioni: Nel granuloma istiocitario unifocale di Langherhans della mandibola l'indagine radiologica � indispensabile per l'approccio allo studio della tumefazione premandibolare fermo restando che la diagnosi di natura si basa esclusivamente sulla biopsia. Oltre all'esame radiologico digitale o

  13. Case anglysis for a patient with post-operative orbital cellulitis and endophthalmitis%1例白内障术后眼眶蜂窝织炎合并眼内炎患者的病例分析

    Institute of Scientific and Technical Information of China (English)

    韩芙蓉; 刘妍; 赵环宇; 李荔

    2015-01-01

    Objective:To analyze the common pathogenic bacteria of endophthalmitis and the selection of anti-infective drugs. Methods: According to the guidelines and patients' condition, the pharmaceutical care conducted by clinical pharmacist on a patient with post-operative orbital cellulitis and endophthalmitis was analyzed.Results:Clinical pharmacist can provide pharmaceutical care in the aspects of dose adjustment, blood concentration monitoring and adverse effects. Conclusion:Clinical pharmacist can take part in the clinical treatment so as to ensure the safet, effective, economic and suitable application of medications.%目的: 分析白内障术后眼内炎的常见致病菌以及抗感染药物的选择.方法:根据指南,结合患者病情,分析临床药师参与1例白内障术后眼内炎患者的药学监护点.结果:临床药师可以从药物剂量调整、血药浓度监测、不良反应监测等方面对患者进行药学监护.结论:临床药师参与临床治疗实践,有利于更好地保障患者用药的安全、有效、经济、适宜.

  14. 口底重症多间隙感染41例患者诊治的回顾性分析%Treatment of severe cellulitis of the mouth floor:A retrospective study of 41 cases

    Institute of Scientific and Technical Information of China (English)

    乔波; 张浚睿; 陆斌; 孔亮; 刘芳; 封兴华

    2015-01-01

    目的:回顾性分析41例口底重症多间隙感染患者的临床诊治资料。方法:对患者性别、年龄、流行病学特征、感染的诱因、症状、初步诊断、重要伴发疾病、合并症、临床诊断、抗生素的使用(种类及疗程)、手术干预及转归等方面进行总结及系统性分析。结果:男女比例为2.4∶1,年龄10~93岁(平均46.23岁),农村城市比例为3∶1。14.6%患者初步诊断不准确。31%患者在发病后5 d 内就诊。82.9%患者为牙源性感染,35%患者初诊时炎症已扩散至咽旁间隙、翼下颌间隙或者合并颈部感染,7.5%患者感染扩散至纵膈;2例患者入院后已合并严重纵膈及肺部感染,转呼吸内科治疗,1例因肾衰转泌尿外科治疗;38例患者入院后及时给予静脉滴注抗生素抗感染治疗、尽早完成切开引流,痊愈出院,平均住院21 d。结论:牙源性感染的重症口底多间隙感染最多见,其治疗的关键在于早期诊断,维持呼吸道通畅,选择合适的抗生素,尽早切开引流、综合治疗去除病因。%Objective:To analyze clinical data of 41 patients with severe mouth floor cellulitis.Methods:Patient's gender,age, epidemiological characteristics,origin of inflammation,symptoms of the disease,primary diagnosis,concomitant diseases,complica-tions,clinical diagnosis,the use of antibiotics (type and course),operation and outcomes were reviewed.Results:The male-fe-male ratio of the patients was 2.4∶1 .Age distribution was 1 0 -93 years old(with the mean of 46.23).The cases from urban-rural area was 3∶1 ,1 4.6% of the patients'primary diagnosis was not accurate.Only 31 % of the patients went to doctors in the first 5 days from the beginning of the disease.82.9% of the mouth floor cellulites were odontogenic.35% of the cases were diagnosed to be in-fectious diffusion to parapharyngeal,pterygomandibular spaces or to be complicating with neck

  15. A clinical study on the therapeutic effect of rituximab in combination with autologous peripheral blood stem cell transplantation in treatment of CD20+ B cellulous non-Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Yong-sheng CHEN

    2013-07-01

    Full Text Available Objective To investigate the therapeutic effect of autologous peripheral blood stem cell transplantation (APBSCT in combination with rituximab in treatment of CD20+ B cellulous non-Hodgkin's lymphoma (B-NHL. Methods Sixty patients with CD20+ aggressive or refractory and recurrent B-NHL and treated with APBSCT in our department from Jan. 2005 to Jan. 2011 were admitted. All the subjects were divided into 2 groups according to their own choice: 25 patients received rituximab treatment (treatment group and 35 patients were treated without rituximab treatment (control group. All patients underwent chemotherapy and APBSCT. For patients in treatment group, rituximab was used with CHOP before collecting the stem cells and after the transplantation. After transplantation, rituximab and IL-2 were used in treatment group every 3-6 months as maintenance treatment. Results No side effect was observed during the use of rituximab either before or after transplantation. The mononuclear cell count in treatment and control group was (8.2±2.9×108/kg and (8.4±3.9×108/kg (P=0.822, respectively; CD34+cell count was (12.3±12.7×106/kg and (13.2±13.9×106/kg (P=0.799, respectively. Haemopoiesis reconstruction was successfully achieved in the patients of treatment group, while 3 patients in control group failed to have haemopoiesis reconstruction. No significant difference was found between two groups on the recovery time of neutrophilic granulocytes and platelets. All patients achieved complete remission. The average follow-up time was 22 months. The disease relapsed in two patients in treatment group and six in control group. The 3-year overall survival rate in treatment group (91.6% was a little higher than that in control group (69.5%, P=0.060. Conclusion To patients of CD20+ B lymphoma, the use of rituximab shows no side effect before or after collection of stem cell and hemopoiesis reconstruction, and the overall survival rate may be improved.

  16. CELLULES SOLAIRES PHOTOVOLTAÏQUES PLASTIQUES NANOSTRUCTUREES

    OpenAIRE

    Derbal-Habak, Hassina

    2009-01-01

    The photovoltaic effect is one of the options which significantly developed during the last years in order to find an alternative to non-renewable energy production. In order to reduce the manufacturing costs of photovoltaic devices, a solution consists in replacing silicon by organic materials. The organic solar cells are an emerging technology which ambitions the supply of more flexible solar cells in all the meanings of the term: mechanics, manufacture, electrooptic properties. A challenge...

  17. Periorbital cellulitis due to cutaneous anthrax.

    Science.gov (United States)

    Gilliland, Grant; Starks, Victoria; Vrcek, Ivan; Gilliland, Connor

    2015-12-01

    Virgil's plague of the ancient world, Bacillus anthracis, is rare in developed nations. Unfortunately rural communities across the globe continue to be exposed to this potentially lethal bacterium. Herein we report a case of periorbital cutaneous anthrax infection in a 3-year-old girl from the rural area surrounding Harare, Zimbabwe with a brief review of the literature.

  18. Evaluation of node involvement in non small cell bronchogenic carcinoma. CT-pathology correlation; Valutazione del fattore <> nel carcinoma polmonare non a piccole cellule. Correlazione tra tomografia computerizzata e anatomia patologica

    Energy Technology Data Exchange (ETDEWEB)

    Pirronti, T.; Macis, G.; Sallustio, G.; Minordi, L.M.; Marano, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Radiologia; Granone, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Patologia Chirurgica; Vecchio, F.M. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Anatomia Patologica

    2000-05-01

    metastasis and 2 had lymph nodes either over or less than 1 cm. In all N2 patients the tumor histotype and the mediastinal location were also considered relative to the lesion site. A closer correlation was found with node morphology and density than with size. Indeed, CT sensitivity, specificity and diagnostic accuracy were 97, 100 and 97%, respectively, for the former versus 52, 93 and 77% for the latter. Adeno-carcinoma was the predominant histotype (70.5%) in N2 patients. Metastases to node region 4 were predominant in right upper lobe carcinomas while node region 5 was predominant in left upper lobe lesions. Other criteria can be associated with size to improve CT diagnostic accuracy in N staging. Technique optimization plays a major role particularly in the late, thin slice, examination phase. [Italian] Scopo di questo lavoro e' valutare il ruolo della TC nell'identificazione di altri segni morfologici di interessamento metafisico dei linfonodi con la finalita' di ottenere migliore definizione del fattore N poiche' elemento critico nella stadiazione di un carcinoma polmonare non a piccole cellule e' il fattore N: essendo il diametro l'unico parametro usato per distinguere i linfonodi normali da quelli patologici, la TC del mediastino presenta accuratezza diagnostica solamente dell'80%. Sono stati studiati 137 pazienti con carcinoma polmonare noto o sospetto. Le scansioni TC sono state eseguite con la seguente tecnica: fase angiografica precoce con tecnica spirale e fase tardiva (ritardo 2 minuti, spessore 3 mm, intervallo 5 mm) per l'identificazione delle caratteristiche linfonodali. Nelle scansioni TC cosi' ottenute i linfonodi, localizzati in accordo alla mappa linfonodale secondo l'American Thoracic Society modificata da Mountain e Dresler, sono stati considerati nomrali quando non visibili o, se visibili, con diametro inferiore a un cm e con densita' omogenea; un linfonodo con diametro superiore a un cm con

  19. 深圳市大鹏新区儿童小细胞低色素性贫血流行现状及病因探讨%Epidemic Situation and Causes of Children of Cellule Low Pigment Anemia in Shenzhen Dapeng New District

    Institute of Scientific and Technical Information of China (English)

    招湛静; 徐威力; 姚雪淦

    2016-01-01

    目的:了解深圳大鹏新区儿童小细胞低色素性贫血患病现状,为儿童小细胞低色素性贫血的预防和治疗提供科学依据。方法随机收集2014年9月~2016年1月来医院体检儿童2256例,分别对儿童个体中的血液学指标和珠蛋白基因型及铁代谢状态进行检测。结果2256例体检儿童小细胞低色素性贫血患病率为10.6%(239/2256);经基因分析,239例小细胞低色素性贫血患儿中分别检出α-珠蛋白生成障碍性贫血113例[并发铁缺乏症(ID)35例],β-珠蛋白生成障碍性贫血70例(并发ID 15例),α-复合β-珠蛋白生成障碍性贫血28例(并发ID 4例),铁缺乏139例(并发珠蛋白生成障碍性贫血54例),珠蛋白生成障碍性贫血检出率为64.9%(155/239),铁缺乏检出率为58.2%(139/239),珠蛋白生成障碍性贫血并发 ID的发生率为34.8%(54/155);单纯性小细胞低色素症(MCV 和 MCH 均降低,但不贫血)患儿32例,占13.4%(32/239);珠蛋白生成障碍性贫血基因总检出率为65.6%和总携带率为75.0%,其中α-珠蛋白生成障碍性贫血基因缺陷类型主要为--SEA/αα,-α3.7/αα及-α4.2/αα,占93.8%;β-珠蛋白生成障碍性贫血基因缺陷类型主要为 CD41/42,CD17,IVS-II-654及-28,占84.2%。结论深圳大鹏新区儿童发生小细胞低色素性贫血最主要原因是珠蛋白生成障碍性贫血,尤其在单纯性小细胞低色素症中更为突出,其次为 ID和珠蛋白生成障碍性贫血并发 ID。同时,还发现 ID个体有较高的珠蛋白生成障碍性贫血基因检出率,应引起临床和社会高度重视。%Objective To understand the shenzhen Dapeng new district children of cellule low pigment anemia disease status of cellule low pigment anemia for children provide a scientific basis for prevention and treatment.Methods Randomly col-lected 2 256 cases

  20. Integrative treatment of Chinese and Western medicine in the treatment of 24 patients with diabetes combined with acute cellulitis%中西医结合治疗糖尿病并发急性蜂窝组织炎24例

    Institute of Scientific and Technical Information of China (English)

    李轶群; 李亦聪; 钟启腾

    2012-01-01

    目的 观察加味四妙勇安汤治疗糖尿病并发急性蜂窝组织炎的疗效.方法 将在我科住院的48例糖尿病并发急性蜂窝组织炎患者随机分为对照组和观察组,每组各24例.两组均给予基础病、常规换药及抗生素治疗.观察组在对照组治疗基础上给予加味四妙勇安汤治疗.结果 两组总有效率比较差异有统计学意义(P < 0.05);观察组治愈时间及有效时间分别为(12.33±0.94)d及(8.57±1.50)d,均少于对照组,两组比较差异有统计学意义(P < 0.05).结论 使用加味四妙勇安汤治疗糖尿病并发急性蜂窝组织炎,能加快减轻患部肿痛,缩短感染治疗时间,疗效显著.%Objective To observed the efficacy of the Decoction of Four Well-matched Potent Herbs for Stopping Groaning in the treatment of diabetes combined with acute cellulitis. Methods 48 patients hospitalized in our department were selected and randomly divided into control group and observation group with 24 patients for each group. Two groups were given foundational disease, conventional medication and antibiotics treatment. The observation group was given the Decoc -tion of Four Well-matched Potent Herbs for Stopping Groaning based on the treatment of the control group. Results Comparison of the two groups showed statistical significance (P < 0.05); but the healing time and improvement time of the observation group were (12.33±0.94) d and (8.57±1.50) d respectively, both of which were less than those of the control group (P < 0.05). Conclusion The application of Decoction of Four Well-matched Potent Herbs for Stopping Groaning in the treatment of diabetes combined with acute cellulitis can accelerate pain and swelling relieving in the affected area and re -duce infection treatment time. Therefore it is significantly effective.

  1. Citotossicity in immune system's cells exposed in vitro to a microwave electromagnetic field in two different exposure systems operating at mobile telephones frequencies; Citotossicita' in cellule del sistema immunitario esposte in vitro al campo elettromagnetico a microonde in due diversi sistemi espositivi operanti alle frequenze della telefonia mobile

    Energy Technology Data Exchange (ETDEWEB)

    Scarcella, E.; Ardoino, L.; Galloni, P.; Mancini, S.; Marino, C. [ENEA, Divisione Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    funzionamento di cellule macrofagiche stabilizzate e coltivate in vitro (RAW 264.7) responsabili dei meccanismi di difesa specifica e aspecifica del sistema immunitario. Sono stati, inoltre, standardizzati due diversi sistemi espositivi operanti a 900 MHz a differenti livelli di densita' di potenza (da 1 a 100 W/m{sup 2}) per garantire condizioni elettromagnetiche omogenee, idonee condizioni di incubazione delle cellule e la riproducibilita' degli esperimenti. Il lavoro di standardizzazione dei sistemi espositivi e i risultati sperimentali di questa ricerca, che hanno evidenziato differenze significative della crescita e della funzionalita' macrofagica solo al livello di densita' di potenza piu' elevato (100 W/m{sup 2}), ma recuperare dopo 48 ore dall'esposizione, risultano essere preliminari e propedeutici per una programmazione sperimentale futura atta ad approfondire una valutazione bio-tossicologica in vitro.

  2. Acute hypocomplementemic post-infectious glomerulonephritis as a complication of sinus-related orbital cellulitis: case report Glomerulonefrite pós-infecciosa hipocomplementêmica aguda como complicação de celulite orbitária relacionada aos seios paranasais: relato de caso

    Directory of Open Access Journals (Sweden)

    Jayter Silva Paula

    2008-08-01

    Full Text Available Group A beta-hemolytic streptococcus is the most common agent implicated in post-infectious acute glomerulonephritis. We report a case of acute poststreptococcal glomerulonephritis associated with sinus-related orbital abscess in an 11-year-old boy treated with surgical drainage and intravenous ceftriaxone and clindamycin. Twelve days after supportive measures, renal function was normalized. We also discuss this potentially severe nonsuppurative complication of orbital cellulitis caused by group A beta-hemolytic streptococcus.Os estreptococos beta-hemolíticos do grupo A são os agentes mais comumente envolvidos na glomerulonefrite aguda pós-infecciosa. Relatamos um caso de glomerulonefrite pós-estreptocócica aguda associada a um abscesso orbitário secundário à sinusite, em menino de 11 anos de idade, o qual foi tratado com ceftriaxona e clindamicina endovenosas e drenagem cirúrgica. Doze dias após tratamento de suporte, a função renal se normalizou. Também discutimos a importância desta grave e potencial complicação não supurativa das celulites orbitárias causadas pelos estreptococos beta-hemolíticos do grupo A.

  3. INDUCTION DE L'IFN- SUR CULTURE DE CELLULES PÉRIPHÉRIQUES MONONUCLÉES CIRCULANTES DE PATIENTS ATTEINTS D'HYDATIDOSE SOUS L'INFLUENCE DE L'ANTIGÈNE-5. PURIFICATION DE L'ANTIGÈNE-5.

    Directory of Open Access Journals (Sweden)

    C TOUIL-BOUKOFFA

    2000-12-01

    Full Text Available L'interféron gamma est produit sur des cultures de cellules mononuclées circulantes stimulées par un antigène parasitaire isolé d'un liquide hydatique hépatique (Antigène-5. L'Antigène-5 est purifié sur SEPHADEX G-200 et identifié comme l'antigène majeur. Notre étude décrit les conditions optimales de production. Le niveau maximal d'interféron est atteint pour une concentration antigénique allant de 2 à 20mg/ml d'Antigène-5. Les titres obtenus sont de 64 U/ml. Le surnageant est absorbé sur acide silique, l'activité antivirale est éluée par un tampon de haute force ionique contenant de l'éthylène glycol et soumis à une chromatographie d’affinité: BLEU SEPHAROSE- CL-6B.  Ce traitement permet une production d’interféron répondant à une activité spécifique de 561,79 U/mg. Nos résultats montrent l’éventuelle implication de cette cytokine dans la défense immunitaire au cours de cette parasitose.

  4. Remote cells destruction; Detruire les cellules a distances

    Energy Technology Data Exchange (ETDEWEB)

    Pezet, A

    2009-11-15

    Three methods for a non invasive surgery are described. High intensity focused ultrasonics to treat an uterine fibroma or prostate cancer presents the advantages to destroy ill cells by high temperature (80 to 100 celsius degrees and the millimetric precision allows to preserve the sane tissues. Echography is used to give images and the volume to treat then are sent the high intensity focused ultrasonics (H.I.F.U.) to destroy the tumor. A second method progresses, the laser method: a thin beam of light, coming from a laser diode and transmitted by an optical fiber of 200 microns diameter comes and heats and kills the cancerous cells. With NMR imaging the cancerous cells from 1 to 2 mm are detected but its is necessary to introduce the optical fiber in the ill tissue. The third method concerns protons therapy used in radiotherapy. The beam energy determines the depth where the protons stop and give their energy (with a 201 MeV energy range the tumors located at 32 centimeters under the skin can be destroyed.The volume to treat is determined with a scanner and a three dimensional calculation reconstruction of image. (N.C.)

  5. Not What It Seems: Deep Tissue Infection Presenting as Cellulitis

    Directory of Open Access Journals (Sweden)

    Caroline T. Brandon

    2015-10-01

    Full Text Available A 34-year-old male with diabetes presented to the emergency department with four days of progressively worsening redness, swelling and pain to his left buttock. The patient denied fevers, chills, rectal pain or purulent drainage from his rectum. His initial vital signs were heart rate of 82; blood pressure of 146/92; and temperature of 98.2°F. The left buttock had a poorly circumscribed area of induration; however, there was no fluctuance or crepitace. Rectal exam was unremarkable. Because the patient’s buttock pain was disproportionate to his exam findings, a point-of-care ultrasound was performed to determine if a more extensive process was present. The ultrasound demonstrated cobblestoning, fascial thickening with edema, and a large 4.5cm fluid collection extending and adjacent to the rectum.

  6. A pilot plant for solar-cell manufacture; Ligne pilote de fabrication de cellules solaires

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, D.; Ziegler, Y.; Closset, A. [VHF - Technologies SA, Yverdon-les-Bains (Switzerland)

    2005-07-01

    A pilot plant for the manufacture of amorphous silicon solar cells on plastic film substrate was built allowing the annual production of 40 kW peak power. The production steps comprise: a) the continuous coating of n-i-p solar cells by VHF-PECVD with a capacity of 28.5 meters in 8.5 hours; b) transparent-conducting-oxide (TCO) top contact structuring using a continuous process; c) series connection step (scribing and Ag-paste) with a capacity of 28 meters in 6 hours; d) back and top contact sputtering with 3 parallel magnetrons; e) integration of a large-area vacuum laminator enabling the simultaneous lamination of 4 products of 4 Wp. In parallel with this project, a complete cost model was established enabling a more quantitative approach of the future technological and industrial strategy of the company. An increase of the capacity to 100 kWp has been planned for summer 2005.

  7. La cellule d'essais du LHC fonctionne avec succès pendant 24h

    CERN Multimedia

    CERN Press Office. Geneva

    1994-01-01

    On 6 and 7 December a string of powerful superconducting magnets for CERN's next particle accelerator the Large Hadron Collider (LHC) ran successfully at 8.36 Tesla for 24 hours. 8.36 Tesla is the magnetic field required to accelerate protons to the required energy for LHC and this result demonstrates that the key technical choices made for the construction of the LHC magnets were correct. The test magnets have shown that they can operate reliably under the same working conditions as the future accelerator.

  8. Polymer photovoltaic cells; Etude et realisation de cellules photovoltaiques en polymere

    Energy Technology Data Exchange (ETDEWEB)

    Sicot, L.

    1999-09-29

    We study organic photovoltaic cells based on a semiconducting polymer. The first photovoltaic cells we realize are Schottky cells. Their structure are ITO/Polymeric film/Au. Metallic electrode is made of aluminium or gold. The organic layer is made of pure poly(3-butyl-thiophene) or of a blend of the polymer and a dye, the 1,3-bis(di-cyano-methylidene)-2-(4-dibutyl-amino-benzylidene)indane. We study the influence of the nature of the electrode on the conversion efficiency. We also study the variations of the photovoltaic parameters as functions of the thickness of the polymeric film and of the doping ratio of the dye. The performances of this kind of cells depends on the interface between the organic layer and the ITO. Its morphology, particularly its rugosity, and its electrical properties are not easy to control. By depositing a layer of a derivative of perylene on the ITO, we move the photo-generation zone to the interface between the two organic films. The efficiency of this p-n cell is higher than the one measured with the Schottky cell. Nevertheless, we have observed a decrease of the performances of our cells due to the degradation of the dye and the polymer when they are illuminated at high intensity of light during a long time. (author)

  9. Orbital wall infarction mimicking periorbital cellulitis in a patient with sickle cell disease

    Energy Technology Data Exchange (ETDEWEB)

    Ozkavukcu, Esra; Fitoz, Suat; Erden, Ilhan [Ankara University School of Medicine, Department of Radiology, Ankara (Turkey); Yagmurlu, Banu [Kirikkale University School of Medicine, Department of Radiology, Kirikkale (Turkey); Ciftci, Ergin [Ankara University School of Medicine, Department of Paediatric Infectious Diseases, Ankara (Turkey); Ertem, Mehmet [Ankara University School of Medicine, Department of Paediatric Haematology, Ankara (Turkey)

    2007-04-15

    Orbital wall infarction and subperiosteal haematomas are unusual manifestations of sickling disorders. Here we report an 11-year-old girl with sickle cell anaemia having multiple skull infarctions including the orbital bony structures associated with subperiosteal haematomas. The diagnosis was made by MRI, which showed bone marrow changes and associated haemorrhagic collections. The patient was successfully managed without surgical intervention. (orig.)

  10. HIB-INFECTION: MENINGITIS, CELLULITIS IN THE CHILD OF 6 MONTHS

    Directory of Open Access Journals (Sweden)

    G. A. Harchenko

    2015-01-01

    Full Text Available A clinical case of Hib-infection is the clinic purulent meningitis and pannikulita young child. Shows the complexity of the differential diagnosis of meningitis in combination with panniculitis with meningococcal disease (meningitis, meningokokktsemiya.

  11. Response of hematopoietic stem cells to ionizing radiation; Reponse des cellules souches hematopoitiques aux radiations ionisantes

    Energy Technology Data Exchange (ETDEWEB)

    Simonnet, A

    2008-12-15

    Hematopoietic stem cells (HSCs) maintain blood and immune system throughout life and restore them after hematological injuries. Exposure of an organism to ionizing radiation (IR) causes rapid and acute myelosuppression and challenges the replenishment capacity of HSCs. Yet, the precise damages that are generated remain largely unexplored. To better understand these effects, phenotypic and functional changes in the stem/progenitor compartments of sublethally irradiated mice were monitored over a ten week period after radiation exposure. We report that shortly after sublethal IR-exposure, HSCs, defined by their repopulating ability, still segregate in the Hoechst dye excluding side population (SP); yet, their Sca-1 (S) and c-Kit (K) expression levels are increased and severely reduced, respectively, with a concurrent increase in the proportion of SP{sup SK} cells positive for established indicators of HSC presence: CD150{sup +} and CD105{sup +}. A great proportion of HSCs quickly but transiently enter the cell cycle to replenish the bone marrow of myelo-ablated mice. Ten weeks after, whereas bone marrow cellularity has recovered and hematopoietic homeostasis is restored, major phenotypic modifications can be observed within the Lin{sup -/low} Sca-1{sup +} c-Kit{sup +} (LSK) stem/progenitor compartment: CD150{sup +}/Flk2{sup -} and CD150{sup -}/Flk2{sup +} LSK cell frequencies are increased and dramatically reduced, respectively. CD150{sup +} LSK cells also show impaired reconstitution capacity, accrued number of {gamma}-H2AX foci and increased tendency to apoptosis. This demonstrates that the LSK compartment is not properly restored 10 weeks after sublethal exposure, and that long-term IR-induced injury to the bone marrow proceeds, at least partially, through direct damage to the stem cell pool. Thrombopoietin (TPO) has been shown to promote the survival of lethally irradiated mice when administrated quickly after exposure. We investigated the mechanisms underlying this effect, and found in a competitive transplant experiment that a single TPO administration rescued the IR-impaired reconstitution capacity of HSCs early after exposure. In addition, the use of marrow cells from transgenic ubiquitous luciferase-expressing donors combined with bioluminescence imaging technology provided a valuable strategy that allowed visualizing HSC homing of TPO-treated compared to untreated irradiated donors, and enabled the identification of a preferential cellular expansion sites which were inaccessible to investigation in most studies. Finally, we observed that TPO injection right after irradiation considerably attenuates IR-induced long-term injury to the stem/progenitor compartment. Altogether, these data provide novel insights in the cellular response of HSC to IR and the beneficial effects of TPO administration to these cells. (author)

  12. Cellulitis in a Liver Transplant Patient as an Initial Manifestation of Disseminated Cryptococcal Disease

    Directory of Open Access Journals (Sweden)

    Marcos Davi Gomes de Sousa

    2016-10-01

    Full Text Available A 50-year-old male underwent liver transplantation due to cryptogenic cirrhosis and was admitted with severe pain in the left leg as well as phlogosis. Amoxicillin/clavulanic acid was prescribed, assuming bullous erysipelas. Among the tests performed, the latex agglutination test for the Cryptococcus sp. antigen was positive, and in both the blood culture and blister culture Cryptococcus sp. was isolated. Daily fluconazole was started. Even though liposomal amphotericin B has been started on the fifth day of hospitalization, the patient progressed to death.

  13. Glucolipotoxicité dans les cellules bêta pancréatiques

    OpenAIRE

    Cassel, Roméo

    2014-01-01

    Le diabète de type 2 est une pathologie chronique complexe associant une altération de sécrétion de l'insuline par le pancréas et une résistance à l'insuline au niveau des tissus périphériques, notamment au niveau du foie et du muscle squelettique. Son origine est multifactorielle, alliant des anomalies génétiques et environnementales, en particulier nutritionnelles. Un des mécanismes par lesquels les facteurs nutritionnels (comme les glucides et les lipides en excès) contribuent au développe...

  14. Attivazione delle cellule Natural Killer durante infezione acuta da virus dell'epatite C

    OpenAIRE

    Amadei, Barbara

    2011-01-01

    Il virus dell’epatite C (HCV) è l’agente eziologico di epatiti virali che durante la fase acuta sono spesso asintomatiche, e quindi difficili da diagnosticare. Questo virus è in grado di stabilire un’infezione cronica persistente nella maggioranza degli individui esposti e la risposta immunitaria contro HCV gioca un ruolo importante sia nel controllo virale che nella patogenesi della malattia. Molti lavori hanno studiato il ruolo della risposta dell’immunità adattativa durante la fase acuta d...

  15. ETUDE DES REMANIEMENTS LIPIDIQUES DES CELLULES VEGETALES EN CARENCE DE PHOSPHATE

    OpenAIRE

    Jouhet, Juliette

    2005-01-01

    Phosphate is often a limiting factor for plant growth in soil. In plant cell, phosphate deprivation induces a decrease of phospholipid amount, mobilizing phosphate present in theses molecules. This decrease is compensated by an increase of non phosphorous plastidic glycolipid amount such as digalactosyldiacylglycerol (DGDG). We have shown that under phosphate deprivation a part of phospholipids is transformed into phosphatidylcholine (PC), producing a transitory increase of PC in short time o...

  16. Cellulitis in a Liver Transplant Patient as an Initial Manifestation of Disseminated Cryptococcal Disease

    Science.gov (United States)

    Gomes de Sousa, Marcos Davi; Bernardes Filho, Fred; Barros Costa Fernandes, Luís Eduardo; Guedes Leal, Cássia Regina; Rocha Magalhães, Cristiane; Custódio Neto da Silva, Marcos Antonio; Silva Barcaui, Halime

    2016-01-01

    A 50-year-old male underwent liver transplantation due to cryptogenic cirrhosis and was admitted with severe pain in the left leg as well as phlogosis. Amoxicillin/clavulanic acid was prescribed, assuming bullous erysipelas. Among the tests performed, the latex agglutination test for the Cryptococcus sp. antigen was positive, and in both the blood culture and blister culture Cryptococcus sp. was isolated. Daily fluconazole was started. Even though liposomal amphotericin B has been started on the fifth day of hospitalization, the patient progressed to death. PMID:28101016

  17. Battery charger for solar cells; Chargeur de batterie pour cellules solaires

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2004-09-01

    The main drawback of solar energy concerns its availability and its intensity variations due to the changes in the clouds cover. For a maximum availability, a photovoltaic power supplies must be connected to a battery. Such an association requires a particular circuit for the management of the battery charging and of the energy conversion whatever the lighting conditions. This article describes the scheme of such a circuit. (J.S.)

  18. The radiation effects on the living cell; Les effets des rayonnements sur la cellule vivante

    Energy Technology Data Exchange (ETDEWEB)

    Sage, E.; Dutrillaux, B.; Soussi, Th. [Institut Curie, 75 - Paris (France)]|[Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France); Boiteux, S.; Lopez, B. [CEA-CNRS/Fontenay-aux-Roses, 92 (France); Feunteun, J. [Institut Gustave Roussy, 94 - Villejuif (France)

    1999-06-01

    This publication is a presentation of particular points discussed during the colloquium of the 15-18 june 1999, for which scientific researches are performed at the CEA/CNRS. They deal with the radiobiology, for the radiation effects on living matter; with the DNA, for the knowledge and repair mechanisms on cells submitted to ionizing radiations; with the exposition to UV in correlation with neoplasms; with the P53 gene which is a tumour suppressor. (A.L.B.)

  19. Orbital cellulitis in course of typhoid fever; Zapalenie tkanki oczodolowej w przebiegu duru brzusznego

    Energy Technology Data Exchange (ETDEWEB)

    Nowacka, K.; Szreter, M.; Mikolajewicz, J. [Centrum Zdrwowia Dziecka, Warsaw (Poland)

    1993-12-31

    In 18 months girl with exophthalmus of the left eye and extensive swelling of the soft tissues in both orbits during continued fever was observed. Typhoid fever with a non-typical course and ophthalmic complications were diagnosed on the basis of serological tests. Complete cure after treatment with augmenting was obtained. (author) 10 refs, 2 figs

  20. Integrated Airframe Design Technology (Les Technologies pour la Conception Integree des Cellules)

    Science.gov (United States)

    1993-12-01

    influencing the variables such as frequencies, system outcome. Each participant can displacements, and cyclic strains, are provide information on the...18E/F Optimized Wing Thickness The system was also used by MDC during the proposal phase of the Single Stage Rocket Technology ( SSRT ) program. The

  1. Etude des interactions entre Helicobacter pylori et les cellules épithéliales gastriques

    OpenAIRE

    Mustapha, Pascale

    2011-01-01

    Infection with Helicobacter pylori causes inflammation that can persist asymptomatically or evolve into more severe pathologies such as gastric or peptic ulcers, MALT lymphoma and gastric cancer. The cag pathogenicity island is one of the major virulence factors of this bacterium. Several cytokines and antimicrobial peptides are involved in modulating the inflammatory response of the gastric epithelial mucosa during infection with H. pylori. This work has focused on the study of the interacti...

  2. Influence de revetements bioactifs sur les cellules endotheliales: Vers des protheses vasculaires non thrombotiques

    Science.gov (United States)

    Fadlallah, Hicham

    Developing vascular prostheses of small diameter to replace vessels closed by atherosclerosis remains a challenge because of the risk of thrombosis. Seeding of endothelial cells, which have antithrombogenic properties, is a promising solution, but we must create surfaces which promote their adhesion and retention to resist shear stresses created by the blood flow on the surface. This master's project aimed at investigating the effect of a plasma polymerized coating rich in primary amines (called LP), with or without elements of the extracellular matrix (Fibronectin (FN) or chondroitin sulphate (CS)) on the endothelial cells and hemocompatibility of polyethylene terephthalate (PET). The adhesion, growth and retention of human umbilical vein endothelial cells (HUVECs) on PET and LP, in the presence and absence of FN or CS, have been studied. In addition, platelet adhesion on different surfaces was evaluated by a perfusion test with whole blood, platelets being previously labeled with rhodamine. Finally a double fluorescent labeling (using Cellview Maroon to mark the HUVECs and CD61 antibody for platelets) was developed to study the retention of endothelial cells, under blood flow and verify their non thrombogenic character. The results obtained show that both the LP coating and the adsorbed FN, strongly increase both the cellular adhesion and growth on PET; however they have no additional effect when the two are combined. They also augment cellular retention to surface, but this remains incomplete. Moreover we observed that the plasma coating (LP) greatly increases the thrombogenicity of the surface, with strong platelet adhesion and activation. This thrombogenicity is extremely reduced when endothelial cells cover the surface, but cell loss under the effect of shear produced by the perfusion creates significant areas of platelet adhesion. The grafting of CS on LP also permits good HUVECs adhesion, growth and retention under shear stress on HUVEC, with no difference from the LP alone. In addition, the CS sharply decreases the platelet adhesion, which is found below the value observed for PET. The double cell labeling also showed that cells adhered on LP+CS has an anti-thrombotic phenotype and can resist blood flow. These studies suggest that a coating of CS is a promising strategy for vascular prosthesis given the combination of the good adhesion of endothelial cells and the low thrombogenicity of the underlying surface. Keywords: vascular prostheses, polymers, bioactive coating, thrombogenicity, HUVECs.

  3. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    OpenAIRE

    2012-01-01

    La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB). Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celuliti...

  4. Effects of yeast extract and vitamin D on turkey mortality and cellulitis incidence in a transport stress model.

    Science.gov (United States)

    We evaluated yeast extract (YE) and vitamin D (VD) in turkeys treated with dexamethasone (Dex) at intervals designed to simulate transport stress during a 3 stage growout. YE but not VD decreased early mortality (P = 0.001) and mortality at wk 7 (P= 0.02) and wk 12 (P = 0.002) but not wk 16. Celluli...

  5. Analisi di costo di pemetrexed vs docetaxel nel trattamento di seconda linea del carcinoma polmonare non a piccole cellule

    Directory of Open Access Journals (Sweden)

    Roberto Ravasio

    2005-06-01

    Full Text Available OBJECTIVES: to compare costs of pemetrexed versus docetaxel in patients with non-small cell lung cancer previously treated with chemotherapy paying special attention to the adverse events. MATERIALS AND METHODS: a cost analysis was carried out performing comparison between pemetrexed and docetaxel. Clinical data (overall survival and resource consumption (chemotherapy drugs, G-CSF, and hospitalizations due to adverse events were obtained from a randomized phase III trial. The economic evaluation was based on direct costs using local Italian unit costs (euro 2005. The perspective was the National Health Service’s. RESULTS: the study results showed that mean survival of pemetrexed (8,3 months; 0,69 years was higher than mean survival of docetaxel (7,9 months; 0,66 years. The mean cost of treatment with pemetrexed was 8.684,26 euros and with docetaxel was 6.182,87 euros. This difference was nearly offset by the difference in the costs of adverse events: the mean cost of adverse events due to chemotherapy treatment with pemetrexed (493,93 euros turned out to be lower than with docetaxel (2.394,34 euros. CONCLUSION: the present cost-analysis could be a stable ground for a further cost-utility analysis, aimed at reaching a more cost-effectiveness management of the chemotherapy-related adverse effects in patients with NSCLC.

  6. Ruolo della Interleuchina-6 nella colite ulcerosa long-standing: regolazione della p53 ed induzione delle cellule mesenchimali epiteliali

    OpenAIRE

    Liguori, Giuseppina

    2013-01-01

    L’infiammazione cronica è un fattore di rischio di insorgenza del cancro, e la citochina infiammatoria IL-6 gioca un ruolo importante nella tumorigenesi. In questo studio abbiamo dimostrato che L’IL-6 down-regola l'espressione e l'attività di p53. In linee cellulari umane, IL-6 stimola la trascrizione dell’rRNA mediante espressione della proteina c-myc a livello post-trascrizionale in un meccanismo p38MAPK-dipendente. L'up-regolazione della biogenesi ribosomiale riduce l'espressione di p53 a...

  7. Etude de la corrosion caverneuse d'un acier inoxydable martensitique : utilisation d'une cellule à couche mince

    OpenAIRE

    Joly Marcelin, Sabrina

    2012-01-01

    Les aciers inoxydables martensitiques sont utilisés dans l'industrie aéronautique où de hautes propriétés mécaniques sont requises. Cependant, dû à leur faible teneur en chrome, ils sont relativement sensibles à la corrosion localisée et particulièrement à la corrosion caverneuse qui se développe en milieu confiné. Tout d'abord, le comportement électrochimique de l'acier inoxydable martensitique X12CrNiMoV12-3 a été étudié dans une solution neutre et chlorurée (NaCl 0,1 M + Na2SO4 0,04 M) en ...

  8. Neurohypophysis granular cell tumours. Upon neurohypophysis rare tumours; Les tumeurs a cellules granuleuses. Des tumeurs rares de la neurohypophyse

    Energy Technology Data Exchange (ETDEWEB)

    Barrande, G.; Kujas, M.; Gancel, A.; Turpin, G.; Bruckert, E.; Kuhn, J.M.; Luton, J.P. [Hopital Cochin, 75 - Paris (France)

    1995-10-01

    Granular cell tumours of neurohypophysis are rare. These tumours are more often encountered as incidental autopsy findings seen in up to 17 % of unselected adult autopsy cases. There are few reports of para-sellar granular cell tumours large enough to cause symptoms. We present three cases of neurohypophysis granular cell tumour and a review of the literature. In one patient, the asymptomatic granular cell tumour was incidentally discovered at surgical removal of a corticotrophic micro-adenoma. The remaining 2 patients had a symptomatic tumour which caused neurological symptoms such as visual disturbance and headaches and endocrine disorders such as hypopituitarism or hyper-prolactinaemia. In these 2 cases, computerized tomography showed a well-circumscribed, contrast-enhanced, intra-sellar and supra-sellar mass. Magnetic resonance imaging demonstrated an isointense gadolinium-enhanced mass in T1-weighted-images. Trans-sphenoidal partial resection was performed and histology was interpreted as a granular cell tumour. The immunohistochemical study was positive for glial fibrillary acidic protein (GEAP) and neuron specific enolase (NSE) in 1 of the 2 tumours and positive for S100 protein and vimentin in both tumours but negative for CD68. The histogenesis of neurohypophysis granular cell tumours is still controversial but ultrastructural and immunohistochemical studies support the theory that may arise from pituicytes, the glial cells of neurohypophysis. Management of these benign, slow growing, tumours is based mainly on neurosurgical resection. Data from the literature do not support a beneficial effect of post operative radiation therapy on postoperative recurrences. (authors). 23 refs., 4 figs., 1 tab.

  9. Cirrhosis, cellulitis and cats: a 'purrfect' combination for life-threatening spontaneous bacterial peritonitis from Pasteurella multocida.

    Science.gov (United States)

    Hey, Penelope; Gow, Paul; Torresi, Joseph; Testro, Adam

    2012-11-11

    Pasteurella multocida is a Gram-negative coccobacillus that colonises the upper airways of many animals, in particular, dogs and cats. It acts as an opportunistic infection in humans following an animal bite or scratch and is associated with soft tissue infections, septicaemia and pneumonia, particularly in patients with a compromised immune response, such as patients with liver failure. Spontaneous bacterial peritonitis (SBP) is a serious complication of cirrhosis with a death rate of 10-15%. We report a case of a 47-year-old man with cirrhosis who presented with life-threatening P multocida SBP and bacteraemia secondary to a lick from a cat to a cellulitic leg wound. This case highlights the potential severity of an infection from domestic animals and an otherwise innocuous organism in an immunocompromised host.

  10. A Homeopathic Arnica Patch for the Relief of Cellulitis-derived Pain and Numbness in the Hand.

    Science.gov (United States)

    Barkey, Elisabeth; Kaszkin-Bettag, Marietta

    2012-05-01

    大拿山金车 (Arnica montana)是一 种菊 (Compositae) 科植物,在用 于缓解肌肉和关节疼痛和/或炎 症方面具有悠久历史,因此有望 成为非甾体类抗炎药的替代品, 而这些非甾体类抗炎药往往效果 不佳或容易导致许多负面作用。 顺势山金车药贴(根据《美国顺 势疗法药典》(Homeopathic Pharmacopoeia of the United States) 3 倍稀释)已开发用于缓解背部和 颈部肌肉及关节疼痛症状。案例简报: 此案例报告描述了一 位 55 岁的女性患者因手掌部位患 蜂窝织炎而出现右手疼痛,第四 指麻痹后,接受山金车药贴治疗 的效果。她曾接受抗生素治疗蜂 窝组织炎,但即使口服布洛芬并 口服及局部外用含山金车的复合 顺势疗法的产品,疼痛症状仍维 持在视觉模拟量表 (visual analog scale, VAS)(将疼痛分为 0 至 10 级)中的 7 级。医生向该患者配发了十张山金车 药贴。她将药贴裁成条状贴在手 上所有疼痛的部位,并在夜间用 药。3 天后,她报告疼痛症状大为 减轻 (VAS = 1) 且麻木的症状和 第三掌骨部位疼痛结节的大小均 显著减小。此外,该患者还能够 彻夜安睡而不被疼醒。在接下来 的 2 天里,症状进一步缓解。 结论: 此案例证实,在患者手上 施用山金车药贴后,经过相对较 短的时间,可显著减轻疼痛并恢 复手部功能。

  11. Cellules solaires avec absorbeur II - VI nanostructuré : matériaux et propriétés

    OpenAIRE

    Salazar, Raùl

    2012-01-01

    The development of semiconducting materials for the extremely thin absorber (eta)solar cell using cheap and scalable methods was the main objective of this work. The eta-solarcell is composed of all inorganic materials consisting of an extremely thin layer of absorbingmaterial (1.1

  12. L'autonomie comme capacité d'action : Une expérience de cellules autonomes dans l'aéronautique

    OpenAIRE

    Bercot, Régine

    1999-01-01

    L'activité au sein des équipes autonomes peut être définie comme processus interactif qui permet d'élargir et diversifier le champ d'intervention, développer la responsabilité individuelle et collective au sein du groupe. Pour traiter de la conquête d'autonomie dans un nouveau cadre organisationnel, nous nous centrons sur l'analyse du processus de mise en place des équipes autonomes. Nous en décrivons le processus de mise en place. Ce processus se joue sur un plan politique ; répondre ou non ...

  13. Mechanisms of mutagenesis in mammalian cells. Application to human thyroid tumours; Mecanismes de mutagenese dans les cellules de mammifere. Le modele des tumeurs thyroidiennes humaines

    Energy Technology Data Exchange (ETDEWEB)

    Sarasin, A.; Bounacer, A.; Lepage, F.; Guillermo Suarez, H. [Institut de Recherches Scientifiques sur le Cancer, 94 - Villejuif (France). Laboratoire de Genetique Moleculaire, UPR 42 CNRS; Schlumberger, M. [Institut Gustave Roussy, 94 - Villejuif (France). Service de Medecine Nucleaire

    1999-03-01

    Mutations are defined as stable and irreversible modifications of the normal genetic message due to small changes in the number or type of bases, or to large modifications of the genome such as deletions, insertions or chromosome rearrangements. These lesions are due to either polymerase errors during normal DNA replication or unrepaired DNA lesions, which will give rise to mutations through a mutagenic pathway. The molecular process leading to mutagenesis depends largely on the type of DNA lesions. Base modifications, such as 8-oxo-guanine or thymine glycol, both induced by ionizing radiations (IR), are readily replicated leading to direct mutations, usually base-pair substitutions. The 8-oxo-G gives rise predominantly to G to T transversions, the type of mutations found in ras or p53 gene from IR-induced tumors. Bulky adducts produced by chemical carcinogens or UV-irradiation are usually repaired by the nucleotide excision repair (NER) pathway which is able to detect structural distortion in the normal double-strand DNA backbone. These lesions represent a blockage to DNA and RNA polymerases as well as some signal for p53 accumulation in the damaged cell. In the absence of repair, these lesions could be eventually replicated owing to the induction of specific proteins at least in bacteria during the SOS process. The precise nature of the error-prone replication across an un-excised DNA lesion in the template is not fully understood in detailed biochemical terms, in mammalian cells. IR basically produce a very large number of DNA lesions from unique base modifications to single- or double-strand breaks and even complex DNA lesions due to the passage of very high energy particles or to a local re-emission of numerous radicals. The breakage of the double-helix is a difficult lesionto repair. Either it will result in cell death or, after an incorrect re-combinational pathway, it will induce frame-shifts, large deletions or chromosomal rearrangements. Most of the IR-induced mutations are recessive ones, requiring therefore a second genetic event in order to exhibit any harmful effect and a long latency period before the development of a radiation-induced tumor. The fact that IR essentially induce deletions and chromosomal translocations renders very difficult the use of the p53 gene as a marker for mutation analysis. In agreement with the type of lesions induced by IR, it is interesting to point out that the presence has been observed, in a vast majority of radiation-induced papillary thyroid carcinomas (PTC), of an activated ret proto-oncogene originated by the fusion of the tyrosine kinase 3' domain of this gene with the 5' domain of four different genes. These ret chimeric genes which are due to intra- or inter-chromosomal translocations, were called RET/ PTC1 to PTC5. The RET/PTC rearrangements were found in PTC from children contaminated by the Chernobyl fall-out as well as in tumours from patients with a history of therapeutic external radiation, with a frequency of 60-84 %. This frequency was only 15 % in 'spontaneous' PTC. The type of ret chimeric gene predominantly originated by the accidental or therapeutic IR was different. Indeed, PTC1 was present in 75 % of the tumours linked to a therapeutic radiation and PTC3 in 75 % of the Chernobyl ones. The other forms of RET/PTC were observed in only a minority of the post-Chernobyl PTC (< 20 %). The difference in the frequency of PTC1 and PTC3 in both types of PTC, is statistically significant (p < 10{sup -5}, Fischer's exact test). In two of the post-therapeutic radiation PTC, RET/PTC1 and PTC3 were simultaneously present. A PTC1 gene was also observed in 45 % of the adenomas appearing after therapeutic radiation. The long period of latency between exposure to IR and the appearance of thyroid tumours is probably due to the conversion ofa heterozygote genotype of IR-induced mutations to a homozygote one. It will be interesting to use this time lag in accidental or therapeutic-irradiated patients, to apply anti-promoter agents leading eventually, to a lower level of tumorigenesis. (authors)

  14. Electrode transparente en nanofils d’argent : intégration dans les cellules et modules photovoltaïques organiques sur substrat souple

    OpenAIRE

    Laurans, Gildas

    2016-01-01

    An organic photovoltaic (OPV) cell consists of a thin-layer stack which includes a transparent electrode, usually made of indium tin-doped oxide (ITO). Alternative, indium-free materials, deposited in air with a wet deposition process on large, flexible substrates that are more compatible with the OPV field are currently widely investigated. Silver nanowires (Ag NWs), which represent a serious candidate to replace ITO, are the subject of this thesis. In this work a method to deposit Ag NWs on...

  15. CEA develops organic photovoltaic cells that might replace silicon cells; La promesse du plastique. Le CEA developpe des cellules photovoltaiques organiques qui pourraient detroner le silicium

    Energy Technology Data Exchange (ETDEWEB)

    Donnars, O.

    2003-01-01

    The program ''plastic photovoltaic solar cells'' was launched in june 2002 at LCOF (laboratory of functional organic components - CEA). The aim of this program is to show the feasibility of efficient organic photovoltaic cells. At the moment the most efficient organic cells reach a conversion rate of 3,5 % compared to the average value of 16 % for silicon cells. This program sets a term of 4 years to reach a conversion rate of 5 % and an operating life of 5000 hours. Plastics (or polymers) are less expensive than silicon, are available on an unlimited basis and are environment friendly. Plastics are easy to handle and a sole technology (serigraphy) is necessary for all the stages of the fabrication process of the organic cells: serigraphy technology is used for the deposition of the substrate, of the material in which the conversion takes place, and of the protective skin. (A.C.)

  16. Mesenchymal stem cells favour healing of the cutaneous radiation syndrome; Les cellules souches mesenchymateuses favorisent la cicatrisation des lesions cutanees radio induites

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S.; Mouiseddine, M.; Mathieu, N.; Semont, A.; Monti, P.; Dudoignon, N.; Sache, A.; Boutarfa, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [IRSN, Dir. de radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France)

    2006-10-15

    It has been suggested that human Mesenchymal Stem Cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC in order to limit radiation-induced skin lesions. Immuno-deficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/mn) using a {sup 60} Co source in order to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis following hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immuno-histology and Polymerase Chain reaction (PCR) analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy. (authors)

  17. Merkel cell carcinoma: Outcome and role of radiotherapy; Carcinome a cellules de Merkel: prise en charge et place de la radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Salvador Alonso, R.; Lahbabi, I.; Ben Hassel, M.; Boisselier, P.; Crevoisier, R. de [Centre Eugene-Marquis, Dept. de Radiotherapie, 35 - Rennes (France); Chaari, N. [Institut Gustave-Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); Lesimple, T. [Centre Eugene-Marquis, Dept. d' Oncologie Medicale, 35 - Rennes (France); Chevrier, S. [Centre Hospitalier Prive de Saint-Gregoire, Dept. de Chirurgie Plastique, 35 - Saint-Gregoire (France)

    2008-09-15

    Merkel cell carcinoma (M.C.C.) are rare neuroendocrine malignant tumor of the skin, occurring in elderly patients. It affects primarily the sun-exposed areas of the skin, with approximately 50% of all tumors occurring in the face and neck and 40% in the extremities. Immunohistochemical markers (C.K.20+, C.K.7- and T.T.F.1-) are used to distinguish between M.C.C. and other tumors. M.C.C. have a tendency to rapid local progression, frequent spread to regional lymph nodes and distant metastases. Due to the rarity of the disease, the optimal treatment has not been fully defined. Localized stages (stages I and II) are treated by surgical excision of the primary tumor (with 2 to 3 cm margin) and lymphadenectomy in case of node-positive disease, followed by external beam radiotherapy (E.B.R.T.) to a total dose of 50 to 60 Gy in the tumor bed. Adjuvant E.B.R.T. has been shown to decrease markedly locoregional recurrences and to increase survival in recent studies. Treatment of lymph nodes area is more controversial. Chemotherapy is recommended only for metastatic disease. (authors)

  18. Treatment of radioinduced skin burns by adult stem cells;Traitement des brulures cutanees radio-induites par cellules souches adultes

    Energy Technology Data Exchange (ETDEWEB)

    Lataillade, J.J.; Prat, M. [Hopital Militaire Percy, Centre de Transfusion Sanguine des Armees, Dept. Recherches et Therapies Cellulaires, 92 - Clamart (France); Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France); Bey, E. [Hopital Militaire Percy, Service de Chirurgie Plastique, 92 - Clamart (France)

    2009-12-15

    In the area of skin injuries caused by ionizing radiations; the recent opportunity give us the the possibility to manage victims of radiation accidents with skin acute symptoms of irradiation. The approach of cell therapy developed for these patients could be in a second time, used for other types of injuries as thermal burns and the injuries linked to overexposure in radiotherapy. In spite of the diversity of approaches of allogeneic and autologous transplantation, the prognosis of deep and extended radioinduced burns is not completely satisfying because of inflammatory recurrences, origin of graft failures. The stem cells have been used in association. The stem cells were got from sampling of autologous bone marrow after an expansion in vitro from 15 to 17 days. The cultures were realised in medium with 8% of platelet lysate (clinical grade). The cells have been given by injection in complement of epidermis auto graft. A spectacular effect was noticed the day after the injection, but disappearing in some days encouraging to realize supplementary injections. An effect of the quickness and the quality of the graft success is appeared significant too. no necrosis recurrence for the patients after four years for the first one of them. We think that the stem cells participate to the local control of inflammation. (N.C.)

  19. Influence de l’hypoxie sur la susceptibilité des cellules tumorales à la lyse induite par les lymphocytes T cytotoxiques

    OpenAIRE

    2012-01-01

    Hypoxia is a common feature of solid tumors and one of the hallmarks of tumor microenvironment. Tumor hypoxia plays an important role in angiogenesis, malignant progression, metastatic development, chemo-radio resistance and favours immune evasion by the emergence of tumor variants with increased survival and anti-apoptotic potential. There is very little work done on the impact of tumor hypoxia on the regulation of tumor susceptibility to the lysis induced by cytotoxic antitumor response. Th...

  20. New method of determining the thermal utilization factor of a cell; Nouvelle methode de determination du facteur d'utilisation thermique d'une cellule

    Energy Technology Data Exchange (ETDEWEB)

    Amouyal, A.; Benoist, P. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1956-07-01

    A new formula for the thermal utilization factor is derived, which, while comparable in simplicity to the formula given by elementary diffusion theory, furnishes much more precise results. This is clearly brought out by comparison with the results given by the S{sub n} and spherical harmonics methods. (author) [French] Une nouvelle expression du facteur d'utilisation thermique, d'une simplicite comparable a celle de Ia theorie elementaire, est etablie. La comparaison avec les resultats fournis par la methode S{sub n} et les methodes d'harmoniques spheriques montre que la precision obtenue par cette formule est tres superieure a celle que donne la theorie elementaire. (auteur)

  1. Simulation, elaboration and analysis of inter-digitated back-contacts photovoltaic cells; Simulation, fabrication et analyse de cellules photovoltaiques a contacts arrieres interdigites

    Energy Technology Data Exchange (ETDEWEB)

    Nichiporuk, O

    2005-05-15

    Solar energy is the most promising and powerful energy source among renewable energies. Photovoltaic electricity is obtained by direct transformation of the sunlight into electricity by means of photovoltaic cells. The objective of this work is to develop photovoltaic cells with back inter-digitated contacts. In the first chapter, we recall the principle of operation and the fundamental parameters of a photovoltaic cell. In a second part, we explain specificities of the inter-digitated back-contact solar cells, as well as the advantages and the disadvantages of such cells. In the second chapter we study the operation of inter-digitated back-contacts solar cells by two dimensional numerical simulation in order to optimize the geometry and doping profiles of the cell. The third chapter relates to the techniques and the methods of characterization of photovoltaic devices and components. In the fourth chapter, we describe the elaboration of inter-digitated back-contact cells. Three technological processes are presented in order to develop a simple technology for cells realization. In particular, we develop the auto-aligned technological process, which enables to elaborate the cells by using only one lithography step. In the last chapter we examine various approaches to reduce the surface recombination: SiO{sub 2}, silicon nitride deposited by UVCVD, hydrogen annealing, etc... (author)

  2. Simulation, elaboration and analysis of inter-digitated back contacts photovoltaic cells; Simulation, fabrication et analyse de cellules photovoltaiques a contacts arrieres interdigites

    Energy Technology Data Exchange (ETDEWEB)

    Nichiporuk, O

    2005-05-15

    Solar energy is the most promising and powerful energy source among renewable energies. Photovoltaic electricity is obtained by direct transformation of the sunlight into electricity by means of photovoltaic cells. The objective of this work is to develop photovoltaic cells with back inter-digitated contacts. In the first chapter, we recall the principle of operation and the fundamental parameters of a photovoltaic cell. In a second part, we explain specificities of the inter-digitated back-contact solar cells, as well as the advantages and the disadvantages of such cells. In the second chapter we study the operation of inter-digitated back-contacts solar cells by two dimensional numerical simulation in order to optimize the geometry and doping profiles of the cell. The third chapter relates to the techniques and the methods of characterization of photovoltaic devices and components. In the fourth chapter, we describe the elaboration of inter-digitated back-contact cells. Three technological processes are presented in order to develop a simple technology for cells realization. In particular, we develop the auto-aligned technological process, which enables to elaborate the cells by using only one lithography step. In the last chapter we examine various approaches to reduce the surface recombination: SiO{sub 2}, silicon nitride deposited by UVCVD, hydrogen annealing, etc.. (author)

  3. Study on the improvement of the reliability of solar cells on polymer substrates; Etude et amelioration de la fiabilite des cellules solaires sur substrats polymeres

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, D.; Ziegler, Y.; Closset, A.

    2004-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) presents the results of work done on the improvement of the long-term reliability of flexible solar cells deposited on polyimide substrates. Several possibilities were explored simultaneously, including vacuum-de-gassing of the polyimide film, the prevention of water absorption by using diffusion barriers and the reduction of mechanical stress in the thin silicon layers. Work completed is described, including the adaptation of the deposition system, the structuring of metal coatings and improvements to existing equipment to reduce defects caused by dust. The continual effort being made to stabilise the production process and make it economically viable is noted.

  4. Oocyte-somatic cell communication and microRNA function in the ovary: Communication ovocyte-cellule somatique et fonction des microRNA dans l’ovaire

    OpenAIRE

    2010-01-01

    An enormous amount of knowledge about the ovary has been generated over the last two decades, due in part to the development of strategies to genetically manipulate the mouse using embryonic stem cell technology. Our group and others have identified multiple factors that are important and essential at all stages of ovarian folliculogenesis from formation of the primordial factor to ovulation. It is obvious that an oocyte, the key cargo of the ovary, and the surrounding granulosa cells, the su...

  5. Report of a rare case of sepsis caused by Bacillus pumilus in an immunocompetent child with the involvement of soft tissues cellulitis

    Directory of Open Access Journals (Sweden)

    Libera Clemente

    2016-12-01

    Full Text Available Bacillus pumilus is an environmental contaminant, rarely associated with human diseases. In this report we describe a case of a severe sepsis caused by B. pumilus in a 7-year-old healthy child. The microorganism has been isolated from two blood cultures and has been identified using both biochemical tests and mass spectrometry. The patient fully recovered after an ampicillin treatment.

  6. Lemierre's syndrome due to community-acquired meticillin-resistant Staphylococcus aureus infection and presenting with orbital cellulitis: a case report

    Directory of Open Access Journals (Sweden)

    Kadhiravan Tamilarasu

    2008-12-01

    Full Text Available Abstract Introduction Lemierre's syndrome is septic thrombophlebitis of the internal jugular vein leading to metastatic septic complications following an oropharyngeal infection. It is usually caused by the anaerobe, Fusobacterium necrophorum. Of late, meticillin-resistant Staphylococcus aureus is increasingly being recognised as a cause of community-acquired skin and soft tissue infections. We report a rare case of Lemierre's syndrome caused by community-acquired meticillin-resistant Staphylococcus aureus infection. Case presentation A previously healthy 16-year-old girl presented with fever of 13 days duration, painful swelling around the right eye and diplopia followed by the appearance of pulmonary infiltrates. Imaging studies confirmed the clinical suspicion of bilateral jugular venous thrombosis with septic pulmonary embolism. Meticillin-resistant Staphylococcus aureus was isolated on blood cultures. The hospital course was complicated by massive haemoptysis and pulmonary aspiration necessitating mechanical ventilation. The patient subsequently made a complete recovery. Conclusion Lemierre's syndrome, although rare, is a potentially lethal but treatable complication of head and neck sepsis. Early clinical recognition of Lemierre's syndrome and appropriate antibiotic treatment can be life-saving. One should consider the possibility of community-acquired meticillin-resistant Staphylococcus aureus infection in patients with suspected Lemierre's syndrome.

  7. Targeted therapies and radiation therapy in non-small cell lung cancer; Therapies ciblees et radiotherapie dans les cancers bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, S.; Quero, L.; Wong Hee Kam, S.; Maylin, C.; Hennequin, C. [Service de cancerologie radiotherapie, hopital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris (France); Deutsch, E. [UMR 1030 ' radiosensibilite des tumeurs et tissus sains ' , Inserm, 114, rue edouard-Vaillant, 94805 Villejuif (France); Departement de radiotherapie, institut de cancerologie Gustave-Roussy, 114, rue edouard-Vaillant, 94805 Villejuif (France)

    2011-10-15

    Lung cancer is the leading cause of cancer-related death. Between 80-85% of lung cancers are non-small cell lung carcinomas. One third of the patients are diagnosed with locally advanced stage. In this condition, concomitant radio-chemotherapy is the standard treatment for patients with good performance status. Despite important improvements in the last years, non-small cell lung carcinoma prognosis remains poor, with high rates of both local recurrences and metastases. The heterogeneity of molecular characteristics of non-small cell lung carcinoma cells and a better knowledge of potential targets offer promising developments for new pharmacologic agents. Hereafter we will review the currently most studied pathways and the most promising ones for the treatment of locally advanced unresectable non-small cell lung carcinoma. Two of the most attractive pathways where new agents have been developed and assessed in combination with thoracic radiotherapy or radio-chemotherapy are the EGFR pathway (either with the use of monoclonal antibodies or tyrosine kinase inhibitors) and the angiogenesis inhibition. The development of targeted agents could lead to individualized therapeutic combinations taking into account the intrinsic characteristics of tumor cells. Pharmacological modulation of tumour cells radiosensitivity by targeted therapies is only starting, but yet offers promising perspectives. (authors)

  8. Champ dynamique dans une cellule d'échangeur à vortex : 1. Régime d'entrée laminaire

    Science.gov (United States)

    Petitot, Stéphane; Lyazid, Abdel; Devienne, René

    Numerical simulation and LDV measurements are performed for laminar inlet flow condition in a vortex exchange chamber with isothermal conditions. Newtonian and non-Newtonian fluids were used. Experimental measurements are compared to results of numerical computations with good agreement. Both show the existence of a secondary flow generated by hydrodynamical instabilities due to streamline curvature. The main vortex flow appears then to be restricted by this secondary flow.

  9. Indications of hematopoietic stem cell transplantations and therapeutic strategies of accidental irradiations; Indications des greffes de cellules souches hematopoietiques et strategies therapeutiques des irradiations accidentelles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Produced by a group of experts, this document first discusses the issue of accidental irradiations in terms of medical management. They notably outline the peculiar characteristics of these irradiations with respect to therapeutic irradiations. They agreed on general principles regarding casualty sorting criteria and process, and their medical treatment (systematic hematopoiesis stimulation, allogeneic transplantation of hematopoietic stem cells). They discuss some practical aspects of these issues: casualty sorting within a therapeutic perspective (actions to be performed within 48 hours), therapeutic strategies (support therapy, use of cytokines, and therapy by hematopoietic stem cell transplant). They state a set of recommendations regarding the taking into care and diagnosis, therapeutic strategies, research perspectives, and teaching

  10. Etudes spectroscopiques du dopage dans les matériaux II-VI pour les détecteurs infrarouge et les cellules photovoltaïques

    OpenAIRE

    Frédérique, Gemain

    2012-01-01

    This thesis work presents optical and electrical characteristics of dopants in HgCdTe, CdZnTe and CdS layers. These 3 materials II-VI have mutual interest to be used in detection devices, for infrared light detection with HgCdTe and CdZnTe or for visible light detection in the case of CdS. Optical characterization of these II-VI layers was carried out with photoluminescence and was correlated with electrical measurements realized by temperature dependant Hall effect. First, a study of intrins...

  11. In vitro preparation of radionuclides labeled blood cells: Status and requirements; Preparation in vitro des cellules du sang marquees par des radionucleides: statut et recommandations

    Energy Technology Data Exchange (ETDEWEB)

    Couret, I. [Service de medecine nucleaire et radiopharmacie, hopital Lapeyronie, CHU de Montpellier, 34 - Montpellier (France); Desruet, M.D. [Service de medecine nucleaire et radiopharmacie, CHU de Grenoble, 38 - Grenoble (France); Bolot, C. [Service de pharmacie, hospices civils de Lyon, groupement hospitalier Est, 69 - Bron (France); Chassel, M.L. [Service de pharmacie et radiopharmacie, centre hospitalier de Chambery, 73 - Chambery (France); Pellegrin, M. [Inserm U896, CRLC Val-d' Aurelle-Paul-Lamarque, IRCM, universite Montpellier 1, 34 - Montpellier (France)

    2010-11-15

    Labelled blood cells permit nuclear medicine imaging using their physiological behaviours. The radiolabeling must be performed in vitro because of the lack of specific markers and requires several highly technical stages of preparation. Labelled blood cells have not the medication drug status, so that the nuclear physician conducting the nuclear test is fully liable. In most cases, the physician delegates the technical responsibility to radio-pharmacists. Although the status of radiolabelled autologous cells is not legally defined and in the absence of a specific repository, it is essential that their preparation is subject to the requirements of the rules of French Good Manufacturing Practice published by Agence francaise de securite sanitaire des produits de sante (Afssaps). It would be desirable to harmonize the practices of radiolabeling cellular blood components by editing a repository. (authors)

  12. Studio ultrastrutturale e morfometrico degli effetti in vitro di farmaci secretagoghi e relativi inibitori sulle cellule sierose delle ghiandole sottomandibolare e parotide umane

    OpenAIRE

    Perra, Anna

    2007-01-01

    La ricerca consiste nello studio, mediante la microscopia elettronica, dei processi di secrezione delle ghiandole salivari umane normali in condizioni di stimolazione in vitro con diverse sostanze in grado di interagire coi recettori cellulari. Seguendo tale intento, abbiamo condotto questa ricerca prendendo in considerazione specificatamente gli adenomeri sierosi delle ghiandole salivari parotide e sottomandibolare umane. Abbiamo pertanto proseguito le nostre ricerche sulla secrezione saliva...

  13. Mesenchymal stem cells, a hope for the treatment of radiotherapy complications; Les cellules souches mesenchymateuses, un espoir pour le traitement des complications des radiotherapies

    Energy Technology Data Exchange (ETDEWEB)

    Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire, Dir. de la Radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France); Semont, A.; Benderitter, M. [Institut de Radioprotection et de Surete Nucleaire. Laboratoire de Radiopathologie et Therapies Experimentales, 92 - Fontenay-aux-Roses (France)

    2010-10-15

    This article reports experimental researches performed by IRSN researchers in the field of cell therapy, notably for the treatment of severe accidental radiological burns. It shows than mesenchymal stem cells have been very efficient for the treatment of radio-induced of muscular cutaneous lesions, notably by reducing the pain where conventional analgesic treatments fail. A positive effect has been also obtained by using these stem cells for the treatment of severe intestinal lesions on mice locally irradiated with high doses. The tumorigenic risk associated with the use of these mesenchymal stem cells is also discussed

  14. Cellules solaires avec un absorbeur ll-Vl nanostructuré Matériaux et Propriétés

    OpenAIRE

    Salazar, Raul

    2012-01-01

    The development of semiconducting materials for the extremely thin absorber (eta) solar cell using cheap and scalable methods was the main objective of this work. The eta-solar cell is composed of all inorganic materials consisting of an extremely thin layer of absorbing material sandwiched between nanostructured transparent electron and hole conductors (Eg ≥ 3.3 eV). Compact and defect free ZnO thin film and nanowires (NWs) were prepared galvanostatically. The ZnO nanowire dimensions were co...

  15. Apport de la pression sur les performances d'une cellule d'électrolyse de la vapeur d'eau à haute température

    OpenAIRE

    Cacciuttolo, Quentin

    2014-01-01

    In order to improve the industrial attractiveness of high temperature steam electrolysis (HTSE), the increase in the operating pressure is one of the most promising solutions. In this context, this study is dedicated to the analysis of the pressure influence on the electrochemical reactions occurring in HTSE. A Model and experimental results dealing with the effect of pressure increase have been carried out. Concerning the cathodic side model, the limiting current density due to the lack of s...

  16. Infections in Combat Casualties During Operations Iraqi and Enduring Freedom

    Science.gov (United States)

    2009-04-01

    2 996.66 Infection joint prosthesis 2 996.67 Infection orthopaedic device 12 Central nervous system 320.89 Meningitis other bacteria 1 320.9...Cellulitis arm 37 682.4 Cellulitis hand 16 682.5 Cellulitis/abscess buttock 1 682.6 Cellulitis leg 77 682.7 Cellulitis foot 30 682.9 Cellulitis/abscess...Abrasion hip/leg infected 3 916.3 Blister hip/leg infected 2 917.3 Blister foot and toes-infected 2 958.3 Post-trauma wound infection 35 997.62 Infection

  17. Nouveaux substrats de silicium cristallin destinés aux cellules photovoltaïque à haut rendement : cas du silicium mono-like et du dopage aux donneurs thermiques liés à l’oxygène pour les cellules à hétérojonction de silicium

    OpenAIRE

    Jay, Frédéric

    2016-01-01

    This study aims to understand the electrical properties impact of the crystalline Silicon on the HeteroJunction (SHJ) solar cells performances and define the required material specifications in terms of minority carrier lifetime and bulk resistivity.In the first part of this work, the potential of the mono-like silicon was evaluated for SHJ solar cells production The high productivity of the crystallization method allows to significantly reduce the material cost. 20% efficiencies comparable t...

  18. Inflammation of the Orbit

    Science.gov (United States)

    ... Boomers Additional Content Medical News Inflammation of the Orbit (Inflammatory Orbital Pseudotumor) By James Garrity, MD, Mayo ... Socket Disorders Cavernous Sinus Thrombosis Inflammation of the Orbit Orbital Cellulitis Preseptal Cellulitis Tumors of the Orbit ...

  19. Imaging of Orbital Infections

    OpenAIRE

    Seyed Hassan Mostafavi

    2010-01-01

    Preseptal and orbital cellulitis occur more commonly in children than adults. The history and physical examination are crucial in distinguishing between preseptal and orbital cellulitis. The orbital septum delineates the anterior eyelid soft tissues from the orbital soft tissue. Infections anterior to the orbital septum are classified as preseptal cellulitis and those posterior to the orbital septum are termed orbital cellulitis. "nRecognition of orbital involvement is important not only...

  20. Impetigo

    Science.gov (United States)

    ... Aid: Poison Ivy/Oak/Sumac First Aid: Skin Infections Cellulitis Eczema Skin, Hair, and Nails Abscess MRSA Staph Infections What Are Germs? Cellulitis Abscess Impetigo Ringworm Cellulitis Hand Washing Impetigo Abscess Staph Infections MRSA Contact Us Print Resources Send to a ...

  1. Effects of the ionising radiations on the structure and the function of the intestinal epithelial cell; Effets des rayonnements ionisants sur la structure et la fonction de la cellule epitheliale intestinale

    Energy Technology Data Exchange (ETDEWEB)

    Haton, C

    2005-06-15

    The intestinal mucosa is a particularly radio-sensitive tissue and damage may occur following either accidental or therapeutic exposure. the deleterious actions of ionizing radiation are linked to the formation of sometimes overwhelming quantities of reactive oxygen species (R.O.S.). Production of R.O.S. is both direct and indirect from the secondary effects of irradiation. A better comprehension of the underlying mechanisms of injury will lead to more adapted therapeutic approaches to limit the harmful effects of irradiation. The homeostasis of the intestinal epithelium is regulated by three factors: proliferation, apoptosis and differentiation. these three factors were studied using the cell model, HT29, in order to analyze modulations of this balance after irradiation. our results, in agreement with other data, showed the establishment of mitotic delay. This arrest of proliferation was followed by apoptosis to be the major mechanism leading to cell death in this model. thus, for the first time, we have shown that irradiated intestinal epithelial cells preserve their capacity to differentiate. This indicates, although indirectly, that intestinal cells have and preserve an intrinsic capacity restore a functional epithelium. R.O.S. are considered as intermediates between the physical nature of radiations and biological responses. It seems essential to understand anti-oxidant mechanisms used by the cell for defence against the deleterious effects of R.O.S post exposure. This study of several anti-oxidant defence mechanisms of intestinal mucosa, was carried out in vivo in the mouse at different times following abdominal irradiation. We observed an early mitochondrial response in the hours following irradiation revealing this organelle as a particular target. We demonstrated a strong alteration of anti-oxidant capacity as revealed by a decrease in S.O.D.s, catalase and an increase of the G.P.X.s and M.T.s. A part of these modifications appeared to depend on an irradiation-induced inflammatory response. Finally, we showed that the loss of catalase is linked to the onset of structural damage to the mucosa. All of these results orient therapeutic strategies towards inducing the proliferation of crypt cells, rather than an inhibition of apoptosis, since the epithelial cells retain differentiation capacity and so production of functional cells. (aut0009h.

  2. Introduction to the reliability study of IGBT switching cells under strong constraints; Introduction a l'etude de la fiabilite des cellules de commutation a IGBT sous fortes contraintes

    Energy Technology Data Exchange (ETDEWEB)

    Vallon, J.

    2003-12-15

    The reliability approach in power electronics is a complex problem including the coupling of current / voltage surges, physical and technological imperfections, from the die to the power circuit. First of all, we define a methodology based on the monitoring of a great number of components, during a long time campaign. Components are 600 V-50 A-20 kHz IGBT-diodes modules working in PWM inverter cells owing to an original opposition method. An exhaustive study of cell-switching failure modes allowed us to design a suitable and efficient protection. Afterwards, a complete reliability test bench was carried out with electrical and thermal monitoring. A preliminary screening protocol was also applied. The first results are presented in this thesis. (author)

  3. Aerodynamic Engine/Airframe Integration for High Performance Aircraft and Missiles (L’Integration Aerodynamique des Moteurs et des Cellules dans les Avions et les Missiles a Hautes Performances)

    Science.gov (United States)

    1992-09-01

    contact entre ]a maquetle et les patois , tout en emptchant urt rdpanitions de pression mesurdes (Fig.8). La nacelle seule provoque unec 6eoulement...8217occupation de la maquente dans ]a seine, des fotrnes intettne, ’decan maximal ye situars a 40% de 1’envergute du tron~on d’aile. En de patois haute

  4. Réalisation de cellules solaires nanostructurées à base de nanofils de ZnO. Matériaux et propriétés

    OpenAIRE

    Sanchez, Sylvia

    2012-01-01

    Nanostructured solar cells have been proposed as a solution for photovoltaic cost reduction and to rival the cost of grid-powered electricity. Regarding this challenge, two kinds of solar cells have been studied within the PhD thesis: the Extremely Thin Absorber Solar cells (eta) and the polymer hybrid solar cell. First, we are reporting on the electrochemical deposition of ZnO 2D layers and nanowires on glass substrates covered with TCO (Transparent Conducting Oxide). It is shown that the ba...

  5. Mass-charge-heat coupled transfers in a single cell of a proton exchange membrane fuel cell; Transferts couples masse-charge-chaleur dans une cellule de pile a combustible a membrane polymere

    Energy Technology Data Exchange (ETDEWEB)

    Ramousse, J.

    2005-11-15

    Understanding and modelling of coupled mass, charges and heat transfers phenomena are fundamental to analyze the electrical behaviour of the system. The aim of the present model is to describe electrical performances of a PEFMC according to the fluidic and thermal operating conditions. The water content of the membrane and the water distribution in the single cell are estimated according to the coupled simulations of mass transport in the thickness of the single cell and in the feeding channels of the bipolar plates. A microscopic model of a Gas Diffusion Electrode is built up to describe charges transfer phenomena occurring at the electrodes. Completed by a study of heat transfer in the Membrane Electrode Assembly, conditions and preferential sites of water vapor condensation can be highlighted. A set of measurements of the effective thermal conductivity of carbon felts used in fuel cells as porous backing layers have also been performed. Although the value of this parameter is essential for the study of heat transfer, it is still under investigation because of the strong thermal anisotropy of the medium. (author)

  6. Study and fabrication of solid oxide fuel cells through tape casting and co-sintering; Etude et realisation par coulage en bande et co-frittage de cellules de pile a combustible a oxydes solides

    Energy Technology Data Exchange (ETDEWEB)

    Grosjean, A

    2004-11-15

    This work is dedicated to the devising of a low-cost fabrication process of solid oxide fuel cells (SOFC). Technical requirements impose the shaping method: stripe casting as well as the materials used: Yttria-stabilized zirconia (YSZ), nickel and lanthanum manganite doped with strontium (LSM). In order to comply with environmental requirements the developed process uses an aqueous barbotine solvent. We get electrodes and the electrolyte separately, the use of an absorbent drying process has enabled us to join 3 layers to form an elementary cell with great interfacial homogeneity. The resistance of the cell to sintering has been improved through the symmetrization of the deformations of the cell. In order to interpret the low electrical properties of the cell and its quick damaging, transmission microscopy studies have been performed. These studies have shown 2 facts. First, 2 isolating phases appear at the cathode (at the LSM/YSZ interface) because of a too high sintering temperature and secondly, a quick clustering of nickel grains appears during cell operation that leads to a local loss of the nickel grid percolation. This problem has been solved by increasing the size of nickel oxide grains from 0.5 {mu}m to 3 {mu}m) to stabilize the microstructure. The issue of the reactivity at the LSM/YSZ interfaces was tackled in 2 different ways, we have tried to lower the sintering temperature by using a zirconia nano-powder first and then by replacing zirconia in the electrolyte by gadolinium-doped ceria. The use of zirconia nano-powder has failed to decrease sintering temperature while preserving the electrolyte density and the use of ceria has triggered instabilities that have not yet been solved. Despite all these drawbacks, this process allows the fabrication of an excellent anode/electrolyte interface. (A.C.)

  7. Synthesis and shaping of new cathode materials for ITSOFC fuel cell: fabrication and test cells; Synthese et mise en forme de nouveaux materiaux de cathode pour piles ITSOFC: realisation et tests de cellules

    Energy Technology Data Exchange (ETDEWEB)

    Lalanne, C.

    2005-10-15

    The development of the Solid Oxide Fuel Cells is dependent on the reduction of the cathodic over-potential measured at 600-700 Celsius degrees. In this way, in the last few years, we have made a selection from new cathode materials in the Institute; the oxygen over-stoichiometric oxides formulated A{sub 2}MO{sub 4+{delta}} (K{sub 2}NiF{sub 4}-type structure), show enhanced electrocatalytic and oxygen conduction properties. A detailed study has been performed on the compositions Nd{sub 2-x}NiO{sub 4+{delta}} (x = 0 and 0.05): the oxygen reduction is characterised by impedance spectroscopy and voltametry measurements (symmetrical configuration cell under air). Electrochemical analysis carried out under different oxygen partial pressures and various cathodic over-potentials have led us to identify the various contributions of the mechanism of the dioxygen reduction. Using powders with controlled morphology (coming from different synthesis ways) has resulted in a reduction of the electrode polarisation phenomena, which is the limiting step of the process still remaining in the interface cathode / electrolyte ionic transfer. In addition, due to these promising results (low area specific resistances and minimized cathodic over-potentials), the first tests in a complete fuel cell device have been performed. After an optimisation of the shaping parameters, i.e. selection of the suitable coating process and of the sintering thermal cycle, promising current densities of 1,3 A/cm{sup 2}, for 0,7 V have been measured at 800 Celsius degrees, the operating temperature. (author)

  8. Study of the cetuximab-ionizing radiation association on a model of in vitro endothelial cells; Etude de l'association cetuximab-radiations ionisantes sur un modele de cellules endotheliales in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Vautravers-Dewas, C.; Rebucci, M.; Lansiaux, A. [Centre Oscar-Lambret, Inserm U837, Lab. de Pharmacologie Antitumorale, 59 - Lille (France); Peixoto, P. [Inserm U837, 59 - Lille (France); Lartigau, E. [Centre Oscar-Lambret, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2009-10-15

    These data support the existence of functional signalling tracks downstream epidermal growth factor receptor (E.G.F.R.) in endothelial cells. But our in vitro model, in two dimensional calculations, did not allow to show a radiosensitivity by cetuximab. The study of functional consequences of the association cetuximab-irradiation treatment will be relevant in an in vitro three dimensional model and on xenografts. (N.C.)

  9. Extension work-up for non-small-cell lung cancer; Thorax - cancer broncho-pulmonaire. Bilan d'extension des tumeurs malignes primitives broncho-pulmonaires non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Ait-Ameur, A.; El Fikri, A.; Teriitehau, C.; Minvielle, F.; Le Bivic, T.; Jeanbourquin, D. [Hopital d' Instruction des Armees Percy, Service d' Imagerie, 92 - Clamart (France)

    2003-02-01

    Surgery is the only potentially effective treatment of the non-small-cell lung neoplasm. Patient selection for surgery requires a rigorous protocol. In order to optimize the therapeutic strategy, the extension work-up must be designed to identify correctly locoregional spread and any contraindications as well as metastasis with assessment of mediastino-pulmonary lymph nodes. Radiology, particularly computed tomography, is highly contributive. Plain chest X-ray, ultrasound, magnetic resonance imaging (MRI) and possibly positron omission tomography (PET) may also be required. (authors)

  10. Modulation de la plasticité synaptique par les prostaglandines E2 à la synapse fibre moussue/cellule pyramidale CA3 en conditions physiologiques et dans un modèle murin de la maladie d'Alzheimer

    OpenAIRE

    2014-01-01

    Alzheimer’s disease (AD) is the most common form of dementia in elder people characterized by a loss of cognitive function linked to synaptic deficits. There is considerable evidence that neuroinflammation and AD are intimately linked. The key role of neuroinflammation in the course of the disease was figured out by epidemiological studies reporting a reduced prevalence to develop AD for patients chronically treated with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Prostaglandins are lipid...

  11. 上颌窦置管引流治疗幼儿鼻及鼻窦炎合并眶蜂窝织炎%Maxillary sinus drainage in the treatment of children's rhinosinusitis with orbital cellulitis

    Institute of Scientific and Technical Information of China (English)

    朱晓远; 娄卫华; 朱洪海; 台勇

    2013-01-01

    目的 探讨上颌寞置管引流治疗幼儿鼻及鼻寞炎(rhinosinusitis,RS)合并眶蜂窝织炎的方法和疗效.方法 21例幼儿RS合并眶蜂窝织炎的患儿应用上颌窦置管引流,合并全身抗生素应用和支持疗法.结果 患儿局部和全身症状在置管后迅速改善,平均术后于6~9d康复出院,无并发症及后遗症.结论 上颌寞置管引流和冲洗、联合抗生寨应用,治疗幼儿RS合并眶蜂窝织炎,是一种安全有效的治疗方法.

  12. Radiosensitizing effect of conjugated linoleic acid in MCF-7 and MDA-MB-231 breast cancer cells; Effet radiosensibilisateur de l'acide linoleique conjugue chez les cellules cancereuses de sein MCF-7 et MDA-MB-231

    Energy Technology Data Exchange (ETDEWEB)

    Drouin, G.; Douillette, A. [Univ. de Sherbrooke, Dept. de medecine nucleaire de radiobiologie, Faculte de medecine, Sherbrooke, Quebec (Canada); Lacasse, P. [Centre de recherche et development sur le bovin laitier et le porc, Lennoxville, Quebec (Canada); Paquette, B. [Univ. de Sherbrooke, Dept. de medecine nucleaire de radiobiologie, Faculte de medecine, Sherbrooke, Quebec (Canada)]. E-mail: benoit.paquette@USherbrooke.ca

    2004-02-01

    Apoptotic pathways in breast cancer cells are frequently altered, reducing the efficiency of radiotherapy. Conjugated linoleic acid (CLA), known to trigger apoptosis, was tested as radiosensitizer in breast cancer cells MCF-7 and MDA-MB-231. The CLA-mix, made up of the isomers CLA-9cis 11trans and CLA-10trans 12cis, was compared to three purified isomers, i.e., the CLA-9cis 11cis, CLA-9cis 11trans, and CLA-10trans 12cis. Using the apoptotic marker YO-PRO-1, the CLA-9cis 11cis at 50 {mu}mol/L turned out to be the best apoptotic inducer leading to a 10-fold increase in MCF-7 cells and a 2,5-fold increase in MDA-MB-231 cells, comparatively to the CLA-mix. Contrary to previous studies on colorectal and prostate cancer cells, CLA-10trans 12cis does not lead to an apoptotic response on breast cancer cell lines MCF-7 and MDA-MB-231. Our results also suggest that the main components of the CLA-mix (CLA-9cis 11trans and CLA-10trans 12cis) are not involved in the induction of apoptosis in the breast cancer cells studied. A dose of 5 Gy did not induce apoptosis in MCF-7 and MDA-MB-231 cells. The addition of CLA-9cis 11cis or CLA-mix has allowed us to observe a radiation-induced apoptosis, with the CLA-9cis 11cis being about 8-fold better than the CLA-mix. CLA-9cis 11cis turned out to be the best radiosensitizer, although the isomers CLA-9cis 11trans and CLA-10trans 12cis have also reduced the cell survival following irradiation, but using a mechanism not related to apoptosis. In conclusion, the radiosensitizing property of CLA-9cis 11cis supports its potential as an agent to improve radiotherapy against breast carcinoma. (author)

  13. In-situ study of the dendritic growth in lithium/polymer electrolyte-salt/lithium cells; Etude in-situ de la croissance dendritique dans des cellules lithium/POE-sel/lithium

    Energy Technology Data Exchange (ETDEWEB)

    Brissot, C.; Rosso, M.; Chazalviel, J.N. [Ecole Polytechnique, 91 - Palaiseau (France); Baudry, P.; Lascaud, S. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches

    1996-12-31

    The in-situ observation of dendritic growth in lithium/polymer electrolyte-LiTFSI/lithium battery cells shows that dendrites grow up with about the same rate as anion migration. Memory effects have been evidenced in cycling experiments and limit the dendrites length. An overall movement of the electrolyte due to variations of electrolyte concentration in the vicinity of the electrodes has been observed too. (J.S.) 13 refs.

  14. Estudo clínico de celulite orbitária e pré-septal na infância Orbital and preseptal cellulitis in childhood: a clinical study

    OpenAIRE

    César Moreira Sampaio; Lívia Maria Bittencourt Nossa; Ana Paula Ramos; Renata Abreu Paim; Roberto Lorens Marback

    2001-01-01

    Objetivo: Estudar retrospectivamente aspectos clínicos e terapêuticos em crianças portadoras de celulite orbitária e pré-septal. Métodos: Foram analisados 52 prontuários de pacientes com idades variando de um mês a doze anos, internados no período compreendido entre 1990 e 1998, com quadro de celulite orbitária ou pré-septal. Resultados: Trauma foi o fator predisponente mais freqüente das celulites orbitárias e pré-septais na infância, seguido pela sinusite e causas não-definidas. As infecçõe...

  15. Développement de procédés pour des cellules photovoltaïques kesterite en couches minces à haut rendement et bas coût

    OpenAIRE

    Vauche, Laura

    2015-01-01

    Facing growing energy demand and increasing concerns about climate change and finite energy sources, solar energy use should increase. The future of the different photovoltaic technologies obviously depends on their power conversion efficiency and cost (summarized by the ratio cost per watt), but also on the elements availability. Thin films of earth-abundant kesterite, Cu2ZnSnS4 (CZTS), Cu2ZnSnSe4 (CZTSe) or Cu2ZnSn(S,Se)4 (CZTSSe), which can be manufactured with low-cost processes, are prom...

  16. Light ions radiobiological effects on human tumoral cells: measurements modelling and application to hadron-therapy; Mesures et modelisation des effets radiobiologiques des ions legers sur des cellules tumorales humaines: application a l'hadrontherapie

    Energy Technology Data Exchange (ETDEWEB)

    Jalade, P

    2005-11-15

    In classical radiotherapy, the characteristics of photons interactions undergo limits for the treatment of radioresistant and not well located tumours. Pioneering treatments of patients at the Lawrence Laboratory at Berkeley has demonstrated two advantages of hadrons beams: the Relative Biologic Effect (the RBE) and the ballistic of the beams. Since 1994, the clinical centre at Chiba, has demonstrated successfully the applicability of the method. A physics group, managed by G. Kraft, at Darmstadt in Germany, has underlined the advantages of carbon beams. An European pool, called ENGIGHT (European Network for LIGHt ion Therapy) has been created in which the French ETOILE project appeared. The purpose of the thesis concerns measurements and models of 'in vitro' human cells survival. In the first part, the nowadays situation in particles interactions, tracks and cells structures and radiobiology is presented here. The second is devoted to the models based on the beam tracks and localization of the physical dose. Discussion of sensitivity to various parameters of the model has been realized with the help of numerical simulations. Finally the predictions of the improved model has been compared to experimental irradiations of human cells with argon and carbon beams of the GANIL machine. Conclusion of such study shows the performance and limits of a local model for predicting the radiobiological efficiency of light ions in hadron-therapy. (author)

  17. Characterisation in vivo of ways of induced deaths by p53, in the male germinal cells; Caracterisation in vivo des voies de mort induites par la p53, dans les cellules germinales males

    Energy Technology Data Exchange (ETDEWEB)

    Coureuil, M

    2006-10-15

    The male germinal cells constitute a heterogeneous cell population including pre-meiotic proliferating cells (spermatogonia) and meiotic cells and post meiotic cells in differentiation (spermatocytes and spermatids). We study the involvement in vivo of the p53 protein in the death of these cells with the help of two models, (1) a transgenic model of infertility, MTp53, in which the p53 is over expressed in the differentiated cells and induced their death, (2) the response of these cells to gamma irradiation, where only the spermatogonia die by apoptosis dependent of p53. We showed that the caspases (cysteine-aspartic proteases) are involved in the terminal differentiation of normal germinal cells. But in the MTp53 model, the p53 induces the death of differentiated cells via the activation of calpains and not of caspases. We studied the response of spermatogonia, to gamma irradiation by a transcriptomic approach, by DNA chips and semi-quantitative RT-PCR. we showed that the puma and dr5 genes are induced by the p53 after irradiation. more, the study of mice invalidated for trail ( the dr5 ligand) or for puma, allowed to demonstrate that the two effectors are essential to the activation of intrinsic and extrinsic ways of apoptosis. (N.C.)

  18. Electrochemical deposition of thin nano-structured layers of CuInS{sub 2} for photovoltaic cells; Depot electrochimique de couches minces nanostructurees de CuInS{sub 2} pour cellules photovoltaiques

    Energy Technology Data Exchange (ETDEWEB)

    Cayzac, R.; Boulc' h, F.; Knauth, P. [Madirel Universite de Provence - 13397 Marseille Cedex 20 (France)

    2006-07-01

    In this work, it has been shown that the electrochemical deposition seems to be a promising synthesis technique because the thickness of the layers and their morphology are well adapted to the photovoltaic application. The example of CuInS{sub 2} has been taken. (O.M.)

  19. In vitro effects of piracetam on the radiosensitivity of hypoxic cells (adaptation of MTT assay to hypoxic conditions); Effets in vitro du piracetam sur la radiosensibilite des cellules hypoxiques (adapatation du test au MTT aux conditions d`hypoxie)

    Energy Technology Data Exchange (ETDEWEB)

    Gheuens, E.E.O.; Bruijn, E.A. de; Van der Heyden, S.; Van Oosterom, A.T. [Universitaire Instelling Antwerpen, Antwerp (Belgium); Lagarde, P. [Universitaire Instelling Antwerpen, Antwerp (Belgium)]|[Institut Bergonie, 33 - Bordeaux (France); Pooter, C.M.J. de [Universitaire Instelling Antwerpen, Antwerp (Belgium)]|[Hopital de Middelheim, Anvers (Belgium); Chomy, F. [Institut Bergonie, 33 - Bordeaux (France)

    1995-12-31

    This paper describes the adaptation of the MTT assay to hypoxic conditions in order to test the in vitro effect of piracetam on hypoxic cells and particularly on the radiosensitivity of hypoxic cells since this drug has shown clinical effect on acute and chronic hypoxia. The V79 cell line was selected by reference to preliminary hypoxic experiments using clonogenic assay and euoxic experiments using clonogenic and MTT assays. Cell growth and survival in our hypoxic conditions were assessed using MTT assay with an enclosure and special 48-well plates both made of glass. Growth curves on glass plates after 1-hour exposure to nitrogen versus air were comparable, so there is no bias effect due to gas composition. Survival curves using MTT versus reference clonogenic assay were comparable after radiation exposure in eu- and hypoxic conditions, and confirm the validity of our original technique for creating hypoxia. The Oxygen Enhancement Ratio was of about 3 for 1-hour hypoxic exposure. Piracetam gave no cytotoxic effect up to 10 mM of piracetam. Growth curves after continuous drug exposure and 1-hour euoxic versus hypoxic exposure gave no cytotoxic effect up to 10 mM of piracetam. Survival curves after continuous drug exposure to 10 mM of piracetam gave no significant effect on the radiosensitivity of hypoxic V79 cells using MTT or clonogenic assay. (author). 32 refs., 6 figs.

  20. Synthesis, characterization and nano-structuration of poly-thiophene derivatives for organic photovoltaic solar cells; Synthese, caracterisation et nanostructuration de derives du polythiophene pour des applications en cellules photovoltaiques organiques

    Energy Technology Data Exchange (ETDEWEB)

    Berson, S

    2007-10-15

    This work is devoted to the synthesis of poly-thiophene derivatives with low bandgap and preserving high oxidation potential. Disubstituted thiophenes and 'Donor-Acceptor' bi-thiophenes were synthesized and then polymerized. The side chains of these polymers, donor or acceptor, were modified in order to tune the properties of material as well from the optical point of view as electrochemical. These polymers were also tested in blend with PCBM in bulk-heterojunction photovoltaic cells. Voc delivered by the devices showed a linear dependence according to the potential of oxidation of the polymers. Copolymers containing cyano-thiophene and alkyl- or alkoxy-thiophene showed values of 0.8 V. However, in spite of power conversion efficiency of 1 %, these performances remain lower than the one obtained with the P3HT. Optimizations in terms of morphology are certainly necessary. Indeed, the morphology of the active layer plays a key role in obtaining high power conversion efficiency. An original technique of nano-structuration of the polymer on a nano-metric scale was developed during this work, leading to the development of fibrillar P3HT. These nano-structures, presenting an important degree of order, are formed spontaneously in solution. Their rate compared to amorphous material is perfectly controllable and adjustable in solution and in solid state. Measurements of mobilities show a strong improvement of the transport of load within these fibrillar layers compared to a traditional film of P3HT obtained without annealing. Power conversion efficiencies of 3.6% on glass and 3.3 % on plastic were reached without annealing. (author)

  1. Influence of the impurity-defect and impurity-impurity interactions on the crystalline silicon solar cells conversion efficiency; Influence des interactions impurete-defaut et impurete-impurete sur le rendement de conversion des cellules photovoltaiques au silicium cristallin

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, S

    2007-05-15

    This study aims at understanding the influence of the impurity - defect interaction on the silicon solar cell performances. We studied first the case of single-crystalline silicon. We combined numerical simulations and experimental data providing new knowledge concerning metal impurities in silicon, to quantify the evolution of the conversion efficiency with the impurity concentration. Mainly due to the gettering effects, iron appears to be quite well tolerated. It is not the case for gold, diffusing too slowly. Hydrogenation effects were limited. We transposed then this study toward multi-crystalline silicon. Iron seems rather well tolerated, due to the gettering effects but also due to the efficiency of the hydrogenation. When slow diffusers are present, multi crystalline silicon is sensitive to thermal degradation. n-type silicon could solve this problem, this material being less sensitive to metal impurities. (author)

  2. Etude de la durabilité de cellules d'électrolyse de la vapeur d'eau à haute température : influence des paramètres de fonctionnement

    OpenAIRE

    Mansuy, Aurore

    2012-01-01

    This work is dedicated to the study on the long term behavior of a solid oxide electrolysis cell (SOEC). More specifically, the target is to identify and understand the influence of main working parameters on the cell durability in order to find the best compromise between performances and durability. The initial part of this work is to characterize electrochemically the single cell selected for the study, that is to say a cathode supported cell of the type LSFC/YDC/8YSZ/Ni-YSZ at different g...

  3. Midterm Health and Personnel Outcomes of Recent Combat Amputees

    Science.gov (United States)

    2010-03-01

    998.5b-998.59 Osteomyelitis: 730.Ub-730.99 Cellulitis : 682.Ub-682.99 Chronic infection of amputation stump: 997.62 Infectioii/inflajiimatory due to...Syndrome Anemia Postoperative Infection Osteomyelitis Cellulitis Heterotopic Ossification Amputation Slump Complications Chronic Infection of Amputation...Infectiims Postoperative Infecüon Osteomyelilis Cellulitis Chronic Infection , Amputation Slump Infection /Inflammatory Due to Device Septicemia Stump

  4. 77 FR 13637 - Notice of Quarterly Report (October 1, 2011-December 31, 2011)

    Science.gov (United States)

    2012-03-07

    ... portfolio at risk >90 days of microfinance institutions at the national level. Operational self- sufficiency... of MFIs inspected by Cellule Supervision Microfinance. Access to Justice Project...........

  5. Sepsis

    Science.gov (United States)

    ... meningitis ) Liver or gallbladder Lungs ( bacterial pneumonia ) Skin ( cellulitis ) For people in the hospital, common sites of infection include intravenous lines, surgical wounds, surgical drains, and ...

  6. Infections

    Science.gov (United States)

    ... Infections Adenovirus Bronchiolitis Campylobacter Infections Cat Scratch Disease Cellulitis Chickenpox Chlamydia Cold Sores Common Cold Coxsackievirus Infections Croup Cytomegalovirus (CMV) Dengue Fever Diphtheria E. Coli ...

  7. Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care

    Science.gov (United States)

    2015-02-16

    Sepsis; Bacteraemia; Meningitis; Abscess; Pneumonia; Osteomyelitis; Cellulitis; Gastro-enteritis With Dehydration; Complicated Urinary Tract Infection; Viral Respiratory Infection Complicated With Hypoxia

  8. Imaging of Orbital Infections

    Directory of Open Access Journals (Sweden)

    Seyed Hassan Mostafavi

    2010-05-01

    Full Text Available Preseptal and orbital cellulitis occur more commonly in children than adults. The history and physical examination are crucial in distinguishing between preseptal and orbital cellulitis. The orbital septum delineates the anterior eyelid soft tissues from the orbital soft tissue. Infections anterior to the orbital septum are classified as preseptal cellulitis and those posterior to the orbital septum are termed orbital cellulitis. "nRecognition of orbital involvement is important not only because of the threatened vision loss associated with orbital cellulitis but also because of the potential for central nervous system complications including cavernous sinus thrombosis, meningitis, and death. "nOrbital imaging should be obtained in all patients suspected of having orbital cellulitis. CT is preferred to MR imaging, as the orbital tissues have high con-trast and the bone can be well visualized. Orbital CT scanning allows localization of the disease process to the preseptal area, the extraconal or intraconal fat, or the subperiosteal space. Axial CT views allow evaluation of the medial orbit and ethmoid sinuses, whereas coronal scans image the orbital roof and floor and the frontal and maxillary sinuses. If direct coronal imaging is not possible, reconstruction of thin axial cuts may help the assessment of the orbital roof and floor. Potential sources of orbital cellulitis such as sinusitis, dental infection, and facial cellulitis are often detectable on CT imaging. "nIn this presentation, the imaging considerations of the orbital infections; including imaging differentiation criteria of all types of orbital infections are reviewed.

  9. Dealing with Cuts (For Parents)

    Science.gov (United States)

    ... For Kids For Parents MORE ON THIS TOPIC Cellulitis First Aid: Cuts Staph Infections Bites and Scratches First Aid: Falls First Aid: ... Out Cuts, Scratches, and Abrasions What's a Scab? Cellulitis Cuts, Scratches, and Scrapes Staph Infections Dealing With Cuts and Wounds Contact Us Print ...

  10. Staphylococcal Infections

    Science.gov (United States)

    ... you should be familiar with include the following: Cellulitis is a bacterial skin infection that first affects the outer layers of the ... skin. Although other types of bacteria can cause cellulitis, Saureus ... may diagnose the infection by examining the area. The doctor may take ...

  11. Childhood Eye Diseases and Conditions

    Science.gov (United States)

    ... have a fever. More serious preseptal or orbital cellulitis infections can cause decreased vision, an inability to move the eye, and the appearance of the eye being pushed forward. What to do: Both forms of cellulitis are serious conditions that require urgent medical attention. ...

  12. 21 CFR 520.88g - Amoxicillin trihydrate and clavulanate potassium film-coated tablets.

    Science.gov (United States)

    2010-04-01

    ... and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep... infections, such as wounds, abscesses and cellulitis/dermatitis due to susceptible strains of beta-lactamase... susceptible strains of E. coli. (iii) Limitations. Skin and soft tissue infections: abscesses,...

  13. Tri-Service Disability Evaluation Systems Database Analysis and Research. Annual Report 2011

    Science.gov (United States)

    2011-12-28

    43 6.1 367: Disorders of refraction and accommodation 8 6.7 401: Essential hypertension 41 5.8 P11: Operations on the cornea 8 6.7 300: Anxiety...aftercare 501 2.6 682: Other cellulitis and abscess 104 2.9 682: Other cellulitis and abscess 463 2.4 300: Anxiety, dissociative and somatoform...procedures 25 3.9 295: Schizophrenic disorders 165 3.6 682: Other cellulitis and abscess 24 3.7 998: Other complications of procedures 164 3.6

  14. Recidiverende halscellulitis hos nyfødt forårsaget af gruppe B-streptokokker

    DEFF Research Database (Denmark)

    Rasmussen, Annett Helleskov; Fenger-Grøn, Jesper

    2011-01-01

    Group B streptococci are an important cause of neonatal infection, and cellulitis is rarely found to be the clinical manifestation. In the present case a premature boy developed cellulitis and antibiotic sensitive group B streptococci were detected in blood culture. Despite pertinent treatment...... for 14 days he developed two relapses. At last antibiotic treatment was continued for a period of six weeks with no further relapse. To our knowledge no cases of relapse of neonatal group B streptococcal cellulitis in spite of recommended dose and duration of antibiotic treatment have been published...

  15. Contribution of the return of experience cell (C.R.E.X.) in the risk prevention and management in radiotherapy; Apport de la cellule de retour d'experience (CREX) dans la prevention et la gestion des risques en radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Coche Dequeant, B.; Dumortier, V.; Bouillon, J.; Cheval, V.; Forrest, M.; Giscard, S.; Lacornerie, T.; Lasue, A.; Malfait, B.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France)

    2007-11-15

    This study concerns the setting up of an analysis and follow up system of unwanted events in the radiotherapy department of the Oscar Lambret center at Lille. This work began on January 2007, the report will precise the functioning details and the first results of this cell. (N.C.)

  16. Estimation of the mediastinal involvement probability in non-small cell lung cancer: a statistical definition of the clinical target volume for 3-dimensional conformal radiotherapy?; Estimation de la propabilite d'envahissement tumoral mediastinal: une definition statistique du volume-cible anatomoclinique pour la radiotherapie conformationnelle des cancers bronchiques non a petites cellules?

    Energy Technology Data Exchange (ETDEWEB)

    Giraud, P.; Dubray, B.; Helfre, S.; Dauphinot, C.; Rosenwald, J.C.; Cosset, J.M. [Institut Curie, Dept. d' Oncologie-Radiotherapie, 75 - Paris (France); Rycke, Y. de [Institut Curie, Dept. de Biostatistiques, 75 - Paris (France); Minet, P. [Centre Hospitalier Universitaire, Service de Radiotherapie, Liege (Belgium); Danhier, S. [Hopital Europeen Georges-Pompidou, Service de Radiotherapie, 75 - Paris (France)

    2001-12-01

    Purpose. - Conformal irradiation of non-small cell lung carcinoma (NSCLC) is largely based on a precise definition of the nodal clinical target volume (CTVn). The reduction of the number of nodal stations to be irradiated would render tumor dose escalation more achievable. The aim of this work was to design an mathematical tool based on documented data, that would predict the risk of metastatic involvement for each nodal station. Methods and material. - From the large surgical series published in the literature we looked at the main pre-treatment parameters that modify the risk of nodal invasion. The probability of involvement for the 17 nodal stations described by the American Thoracic Society (ATS) was computed from all these publications and then weighted according to the French epidemiological data. Starting from the primitive location of the tumour as the main characteristic, we built a probabilistic tree for each nodal station representing the risk distribution as a function of each tumor feature. From the statistical point of view, we used the inversion of probability trees method described by Weinstein and Feinberg. Results. -Taking into account all the different parameters of I the pre-treatment staging relative to each level of the ATS map brings up to 20,000 different combinations. The first chosen parameters in the tree were, depending on the tumour location, the histological classification, the metastatic stage, the nodal stage weighted in function of the sensitivity and specificity of the diagnostic examination used (PET scan, CAT scan) and the tumoral stage. A software is proposed to compute a predicted probability of involvement of each nodal station for any given clinical presentation.Conclusion. -To better define the CTVn in NSCLC 3DRT, we propose a software that evaluates the mediastinal nodal involvement risk from easily accessible individual pretreatment parameters. (authors)

  17. Quantitative analysis of fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images on five patients irradiated for a non-small-cell bronchial cancer; Analyse quantitative d'images de TEP au fluorodesoxyglucose, au fluoromisonidazole et a la fluorothymidine chez cinq patients irradies pour un cancer bronchique non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Thureau, S.; Dubray, B. [Departement de radiotherapie et physique medicale, centre Henri-Becquerel, Rouen (France); Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Modzelewski, R.; Lelandais, B.; Edet Sanson, A.; Gardin, I.; Vera, P. [Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Departement de medecine nucleaire, centre Henri-Becquerel, Rouen (France)

    2011-10-15

    As fluorodeoxyglucose-PET (positron emission tomography) is used for the planning of non-small-cell bronchial carcinoma radiotherapy in order to help to define the gross tumour volume (GTV), and as new tracers have been developed to define a biological target volume, the authors report the comparison of several thresholding methods by using fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images. They notice important differences between the delineated volumes. Short communication

  18. Radioinduced pulmonary fibrosis: prospective study of clinical, dosimetric and biological predictive factors after conformal irradiation of non at small cells bronchi carcinomas; Fibroses radiques pulmonaires: etude prospective des facteurs predictifs cliniques, dosimetriques et biologiques apres irradiation conformationnelle des carcinomes bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Claude, L.; Ginestet, C.; Martel-Lafay, I.; Carrie, C. [Centre Leon-Berard, 69 - Lyon (France); Etienne-Mastroiani, B. [Hopital Louis-Pradel, 69 - Lyon (France); Arpin, D. [Hopital de la Croix-Rousse, 69 - Lyon (France); Vincent, M. [Hopital Saint-Luc-Saint-Joseph, 69 - Lyon (France); Falchero, L. [Hopital de Villefranche, 69 - Villefranche s/Saone (France); Blay, J.Y. [Hopital Edouard-Herriot, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, 69 - Lyon (France)

    2007-11-15

    This broad prospective study confirms the contribution of dosimetry factors ( pulmonary average dose, V10 to V50) in the predictive part for the delayed radioinduced fibrosis. Contrary to the acute radioinduced pneumopathy, no significant relationship has been underlined between the variations of cytokines and the delayed radioinduced fibrosis risk. (N.C.)

  19. Use of HMPAO-{sup 99m}Tc in radio-labelling endothelial cells: application to the study of the behaviour of endothelialized vascular prostheses under shearing constraint; Utilisation de HMPAO-{sup 99m}Tc pour le radio-marquage de cellules endotheliales: application pour etudier le comportement de protheses vasculaires endothelialisees sous contraintes de cisaillement

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Ph.; Bareille, R.; Brouillaud, B.; Barthe, N.; Rouais, F.; Bordenave, L. [Laboratoire de Biophisique, CHU-Bordeaux, 33076 Bordeaux (France)

    1997-12-31

    Insemination of the low-caliber vascular prostheses at the level of their endo-luminal surfaces by a monolayer of endothelial cells (EC) prior to their implantation diminishes their thrombogen character and increases their long-term expectation of permeability in humans. The aptitude of EC of remaining adherent to their support when exposed to the constraints of circulatory flux must be studied in vitro and all the authors quantify these adherence by the measurement of the loss of gamma activity of the vascular prosthesis after radiolabelling of EC by {sup 111}In oxinate. In this work EC of human origin, adherent to the culture surfaces were radiolabelled by HMPAO-{sup 99m}Tc and optimal conditions of the labelling were determined: the effect of increasing concentrations of HMPAO and increasing activities of HMPAO-{sup 99m}Tc on the viability and metabolic activity of EC; the influence of the temperature and of the time of touching on the labelling yield. Subsequently, this conditions were applied to EC having cultivated a innovative vascular prosthesis. Surface micro-auto-radiographies were realized. The best compromise was obtained with 10 MBq/10{sup 6} EC (40 {mu}g of HMPAO/10{sup 6} EC) corresponding to a labelling yield of 13.7 {+-} 0.7 after 3 hours of contact at 37 deg. C. The micro-auto-radiographies allow visualization of the intracellular radioactivity distribution. The study of adherence of EC to the vascular prosthesis, under shearing constraints, by means of a radiotracer provides numerous advantages vs current utilisation of {sup 111}In oxinate

  20. Air breath control radiotherapy in severe insufficiency respiratory patients with N.S.C.L.: application for deformable registration method in thoracic radiotherapy; Radiotherapie avec blocage respiratoire pour les grands insuffisants respiratoires atteints d'un carcinome pulmonaire non a petites cellules (Protocole RESPI 2000): application a la modelisation des deformations d'organes par recalage deformable

    Energy Technology Data Exchange (ETDEWEB)

    Sarrut, D.; Pommier, P.; Carrie, C. [Centre Leon-Berard, Dept. de Radiotherapie, CREATIS, Unite CNRS 5515, Inserm 630, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, Dept. de Biostatistique, 69 - Lyon (France)

    2006-11-15

    Purpose. Using deformable registration methods from a phase two clinical study of air breath control during radiotherapy in patients suffering from severe respiratory insufficiency and non-small cell lung carcinoma. Patients and methods, Between April 2002 and November 2005, 22 patients with severe respiratory insufficiency were treated with curative intent by conformal therapy combined with active breathing control. Results. After a mean of follow-up of 22 months, the local control rate is 28% and the method is feasible despite the severe respiratory insufficiency. However the overall survival is still poor due to metastatic widespread. For the second part of the study, the clinical protocol was also used for two studies using deformable registration methods. In the first study, a deformable registration method has been developed in order to register several breath-hold 3D CT of the same patient acquired at several days of interval. It allowed quantifying the inter-fraction breath-hold reproducibility by analysing the resulting displacement field. For 6 patients, the breath-hold was effective, while for 2 patients, motion greater than 10 mm were detected. The second study aimed to simulate 4D images from 3D breath-hold images. Developing an ad-hoc methodology based on the interpolation of 3D dense deformation fields performed it. The approach has been validated with expert selected landmarks, with accuracy lower than 3 mm. Conclusion. ABC is feasible, even in case of severe insufficiency respiratory syndrome but metastatic widespread disease is still a major challenge even with an acceptable local control rate without serious side effects: regarding the deformable registration method. Such artificial 4D images could allow decreasing the dose need to acquire a full 4D image, to simulate irregular breathing pattern and to be used for 4D dosimetry planning. (author)

  1. DIANE, a simulation code for the interaction of neutrons with living tissues. Application to low doses of fast neutrons on human tumoral cells; DIANE, un code de simulation de l'interaction des neutrons avec la matiere vivante. Applications aux faibles doses de neutrons rapides sur des cellules tumorales humaines

    Energy Technology Data Exchange (ETDEWEB)

    Nenot, M.L

    2003-07-15

    Our work deals with the irradiation of cells and living tissues by 14 MeV neutrons at very low doses (a few 10{sup -2} Gy). Such experiments require an accurate knowledge of the values of neutron dose rates and fluences at the level of cell cultures. We have performed measurements of fluence rates through an activation method applied to gold and copper foils. The fluence rate is deduced from the gamma rays emitted by the irradiated foils. Neutron doses and dose rates have been measured through varied methods: PIN diodes, ionization tissue equivalent chambers, and Geiger-Mueller counters. We have designed the DIANE code to simulate the impact of energetic neutrons on cells. This code can be used with isolated cells or macroscopic tissues, it takes into account the roles of the ionisation electrons produced by recoil nuclei entering the cell. This point is all the more important since recent works have highlighted the impact of very low energy electrons on DNA. (A.C.)

  2. In vitro modulation of radiation-induced FAS-related apoptosis in CD34{sup +} progenitor cells by combination cytokines; Reduction de l'apoptose radio-induite impliquant le recepteur FAS au niveau des cellules hematopoietiques CD34{sup +} par une combinaison de cytokines

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Soutif, A.; Herodin, F

    1998-07-01

    Combination cytokines such as SCF, Flt-3 ligand, IL-3 and thrombopoietin can modulate Fas mRNA expression by in vitro irradiated CD34{sup +} cells which results in a moderate decrease of apoptotic ratio and an improved rate of clonogenicity of the irradiated progenitors. (authors)

  3. In vitro cytotoxic effects of PM{sub 2.5} from the city of Abidjan (Ivory Coast) on human A549 lung cells; Effets cytotoxiques in vitro des PM{sub 2,} {sub 5} de la ville d'Abidjan (Cote-d'Ivoire) sur des cellules pulmonaires humaines

    Energy Technology Data Exchange (ETDEWEB)

    Kouassi, Kouakou-Serge [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire); Billet, Sylvain; Garcon, Guillaume; Verdin, Anthony; Courcot, Dominique; Shirali, Pirouz [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Diouf, Amadou [Laboratoire de Toxicologie, Faculte de Medecine Pharmacologie Odontologie, Universite Cheikh Anta Diop, Dakar (Senegal); Cazier, Fabrice [Universite Lille Nord de France, Lille (France); Centre Commun de Mesures, MREI 1, Universite du Littoral Cote d' Opale, Dunkerque (France); Djaman, Joseph [Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire)

    2012-01-15

    Epidemiological studies associate air pollution, especially particulate, increased morbidity and mortality from respiratory and cardiovascular origin . Africa, which has an urbanization rate among the highest in the world, is particularly exposed. The 'Initiative on the air quality in Sub-Saharan Africa' showed the importance of atmospheric concentrations of certain pollutants such as nitrogen oxides, sulfur dioxide and particulate matter (PM{sub 10}). Like the great capitals of Africa, Abidjan, economic capital and most industrialized city of Ivory Coast is facing an air pollution from industrial-urban and health consequences for its population of nearly 6 million inhabitants. To better understand the mechanisms of action resulting from pulmonary exposure to particulate atmospheric aerosols, we proposed: (i) to collect atmospheric particles (PM{sub 2.5}) using high volume cascade impaction in the District of Abidjan in three influences (rural, urban or industrial), (ii) to determine their main physicochemical, (iii) assess their cytotoxicity and their role in the induction of oxidative damage in a model of human lung cells (A549) in culture. The chemical composition of the atmospheric particles revealed their heterogeneity, and many inorganic (e.g. Al, Ca, Fe, Mn, Zn, Ni, Cr, Cu, Pb, Mg) and organic compounds (e.g. paraffins) were quantified at the three sites. Their effect concentrations (EC) to 10 and 50% on the A549 were as follows: influence rural: EC{sub 10} = 5.91 {mu}g/cm{sup 2} and EC{sub 50} 29.55 {mu}g/cm{sup 2}, urban influence: EC{sub 10} = 5 .45 {mu}g/cm{sup 2} and EC{sub 50} = 27.23 {mu}g/cm{sup 2}, and industrial influence: EC{sub 10} = 6.86 {mu}g/cm{sup 2} and EC{sub 50} = 34.29 {mu}g/cm{sup 2}. Exposure of A549 cells to Abidjan city's PM samples for 24, 48 or 72 hours to their EC{sub 10} or EC{sub 50} induced oxidative damage, as demonstrated by the formation of malon-dialdehyde, changes in enzyme activity of superoxide dismutase and alteration of glutathione status. (authors)

  4. Microsystème dédié à l’étude de la polarisation diélectrique de microparticules dans le cadre de formation master recherche : application au micropositionnement 3D de cellules par force de diélectrophorèse

    OpenAIRE

    Sieskind, Rémi; Trainito, Claudia; Français, Olivier; Le Pioufle, Bruno

    2015-01-01

    International audience; A l’ENS de Cachan, le département E.E.A. a mis en place une série de travaux pratiques portant sur l’utilisation d’un microsystème « électro-fluidique », réalisé en salle blanche, pour le micro-positionnement par champ électrique d’objets inertes ou biologiques de dimension micrométrique. Cet enseignement est développé dans des formations de niveau Master.Le principe physique, exploité au travers des séances pédagogiques, est la polarisation diélectrique de microobjets...

  5. Effect of ionizing radiation on hematopoietic stem cells and progenitor cells: Role of apoptosis and potential therapeutic significance of anti-apoptotic treatments; Effet des rayonnements ionisants sur les cellules souches et progeniteurs hematopoietiques : place de l'apoptose et interet therapeutique potentiel des traitements antiapoptotiques

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mourcin, F.; Grenier, N.; Mayol, J.F.; Leroux, V. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France); Sotto, J.J. [Inst. Albert Bonniot, La Tronche (France); Herodin, F. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France)

    2002-07-01

    Bone marrow aplasia observed following ionizing radiation exposure (Total Body Irradiation; gamma dose range: 2-10 Gy) is a result, in particular, of the radiation-induced (RI) apoptosis in hematopoietic stem and progenitor cells (HSPC). We have previously shown in a baboon model of mobilized peripheral blood CD34{sup +} cell irradiation in vitro that RI apoptosis in HSPC was an early event, mostly occurring within the first 24 hours, which involves the CD95 Fas pathway. Apoptosis may be significantly reduced with a combination of 4 cytokines (4F): Stem Cell Factor (SCF), FLT-3 Ligand (FL), thrombopoietin (TPO), and interleukin-3 (IL-3), each at 50 ng{center_dot}mL{sup -1} (15% survival versus <3% untreated cells, 24 h post-irradiation at 2.5 Gy). In this study we show that addition of TNF-{alpha}(800 IU/ml) induces an increase in 4F efficacy in terms of cell survival 24 h after incubation (26% survival after 24 h irradiation exposure at 2.5 Gy) and amplification (k) of CD34{sup +} cells after 6 days in a serum free culture medium (SFM) (k{sub CD34{sup +}} = 4.3 and 6.3 respectively for 4F and successive 4F + TNF-{alpha}/4F treatments). In addition, the 4F combination allows culture on pre-established allogenic irradiated stromal cells in vitro at 4 Gy (k{sub CD34{sup +}} = 4.5). Overall this study suggests (i) the potential therapeutic interest for an early administration of anti-apoptotic cytokines with or without hematopoiesis inhibitors (emergency cytokine therapy) and (ii) the feasibility in the accidentally irradiated individual, of autologous cell therapy based on ex vivo expansion in order to perform autograft of residual HSPC collected after the accident. (author)

  6. Bulky PAH-DNA induced by exposure of a co-culture model of human alveolar macrophages and embryonic epithelial cells to atmospheric particulate pollution; Adduits encombrants a l'ADN dans des cocultures de cellules pulmonaires humaines exposees a une pollution atmospherique particulaire

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, Imane; Garcon, Guillaume; Billet, Sylvain; Shirali, Pirouz [Universite Lille Nord de France - Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Andre, Veronique; Le Goff, Jeremie; Sichel, Francois [GRECAN, Universite de Caen Basse-Normandie et centre Francois Baclesse, Caen (France); Roy Saint-Georges, Francoise; Mulliez, Philippe [Service de Pneumologie, Hopital Saint-Philibert, GHICL, Lille (France)

    2012-01-15

    Because of their deep penetration in human lungs, fine airborne particulate matter were described as mainly responsible for the deleterious effects of exposure to air pollution on health. Organic constituents are adsorbed on particles surface and, after inhalation, some (polycyclic aromatic hydrocarbons, PAHs) can be activated into reactive metabolites and can bind to DNA. The formation of bulky DNA adducts has been researched after exposure of mono-and co-cultures of alveolar macrophages (AM) and human embryonic human lung epithelial (L132), to fine air pollution particulate matter Air samples have been collected with cascade impactor and characterized: size distribution (92.15% < 2.5{mu}.m), specific surface area (1 m{sup 2}/g), inorganic (Fe, AI, Ca, Na, K, Mg, Pb, etc.) and organic compounds (PAHs, etc.). {sup 32}P post-labeling method was applied to detect bulky DNA adducts in AM and L132, in mono-and co-cultures, 72 h after their exposure to atmospheric particles at their Lethals and Effects concentrations or (LC or CE) to 50% (i.e. MA: EC{sub 50} = 74.63 {mu}g/mL and L132: LC-5-0 = 75.36 {mu}g/mL). Exposure to desorbed particles (MA: C1= 61.11 {mu}g/mL and L132 : C2 = 61.71 {mu}g/mL) and B[a]P (1 {mu}M) were included. Bulky PAH-DNA adducts were detected in AM in mono-culture after exposure to total particles (Pt), to B[a]P and desorbed particles (Pd). Whatever the exposure, no DNA adduct was detected in L132 in mono-culture. These results are coherent with the enzymatic activities of cytochrome P450 l Al in AM and L132. Exposure of co-culture to Pt, or Pd induced bulky adducts to DNA in AM but not in L132. Exposure to B[a]P alone has altered the DNA of AM and L132, in co-culture. Exposure to Pt is closer to the environmental conditions, but conferred an exposure to amounts of genotoxic agents compared to studies using organic extracts. The formation of bulky DNA adducts was nevertheless observed in AM exposed to Pt, in mono- or co-culture, indicating that they were competent in terms of metabolic activation of PAHs. The DNA damage in the L132 in co-culture following exposure to B[a]P have suggested that some PAH metabolites generated by the MA could be have a genotoxic action on L132. (authors)

  7. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  8. Usefulness of {sup 99m}Tc-depreotide scintigraphy for the diagnosis of bone metastases in non-small cell lung cancer stage 3-4; Apport de la scintigraphie au {sup 99m}Tc-depreotide pour le diagnostic de lesions osseuses secondaires dans le cancer bronchopulmonaire non a petites cellules stade 3-4

    Energy Technology Data Exchange (ETDEWEB)

    Costo, S.; Dunet, V.; Agostini, D.; Bouvard, G. [CHU Cote de Nacre, Service de Medecine Nucleaire et Isotopes, 14 - Caen (France); Halley, A. [Centre Havrais d' Imagerie Nucleaire, 76 - Montivilliers (France); Bergot, E.; Porret, E.; Zalcman, G. [CHU Cote de Nacre, Service de Pneumologie, 14 - Caen (France)

    2009-02-15

    Objective In non-small cell lung cancer (NSCLC), metastatic bone involvement is usually assessed using conventional {sup 99m}Tc-HMDP bone scintigraphy, which has a high sensitivity but a poor specificity. The purpose of this study was to assess the usefulness of the {sup 99m}Tc-D scintigraphy for the detection of malignant bone metastases in patients with NSCLC stage III or IV and to compare these results with {sup 99m}Tc-HMDP bone scan findings. Methods Nineteen patients (13 M and 6 F, mean age 59 years) with proven NSCLC, suspected to have stage III or IV were enrolled prospectively. All patients underwent whole body {sup 99m}Tc-HMDP and {sup 99m}Tc-D scintigraphy to detect bone metastases within a mean interval of 14 days. Each focal uptake of {sup 99m}Tc-D or {sup 99m}Tc-HMDP was considered benign or malignant, leading to positive or negative diagnosis for bone involvement. The final diagnosis of bone metastases was established by a lung specialist, on the basis of additional imaging modalities and of 12 months follow-up. Results Twelve bone lesions were identified by {sup 99m}Tc-D scintigraphy, 10 were classified as bone metastases and two were classified as inflammatory bone lesions. Four patients were metastatic. Fifty eight bone lesions were detected by {sup 99m}Tc-HMDP scintigraphy, 26 of whom were considered malignant, eight patients were thus considered metastatic. Thereby, the two nuclear medicine modalities were concordant for 13 patients, that is 68% of cases and were discordant for six patients, representing 32% of cases. Diagnostic sensitivity, specificity and accuracy of depreotide scintigraphy and {sup 99m}Tc-HMDP bone scintigraphy were 75% for both, 93.3 and 73.3%, and 89.5 and 73.3% respectively. Conclusion Our data suggest that depreotide scintigraphy with the same sensitivity, a better accuracy and specificity than those of {sup 99m}Tc-HMDP bone scan can detect metastatic bone lesions in patients with NSCLC suspected to have stage III or IV disease. (authors)

  9. Identification of human genes involved in cellular responses to ionizing radiation: molecular and cellular studies of gene encoding the p68 helicase in mammalian cells; Identification de genes humains impliques dans la reponse cellulaire aux radiations ionisantes: etudes moleculaire et cellulaire du gene codant l'helicase p68 dans les cellules de mammiferes

    Energy Technology Data Exchange (ETDEWEB)

    Menaa, F.

    2003-12-15

    Cells submitted to genotoxic factors -like IR- activate several and important mechanisms such as repair, cell cycle arrest or 'apoptosis' to maintain genetic integrity. So, the damaged cells will induce many and different genes. The human transcriptome analysis by 'SSH' method in a human breast carcinoma cell line MCF7 {gamma}-irradiated versus not irradiated, allowed to identify about one hundred genes. Among of these genes, we have focused our study on a radio-induced gene encoding the p68 helicase. In the conditions of irradiation used, our results show that the kinetic and the regulation of this gene expression differs between the nature of radiations used. Indeed, in {gamma}-irradiated mammalian cells, ATM, a protein kinase activated by DSB and IR, is required to induce quickly P68 gene via the important transcription factor p53 stabilized by IR. In the case of UVC-irradiated cells, the P68 gene induction is late and the intracellular signalling pathway that lead to this induction is independent from the p53 protein. Finally, we show that the p68 protein under-expression is responsible for an increased radiosensitivity of MCF7 cells. Consequently, we can postulate that the p68 protein is involved in cellular responses to radiations to reduce the increased radiosensitivity of cells exposed to {gamma}-rays. (author)

  10. Synthesis of nano-particles by soft chemistry: structural, morphological and dimensional control. Studies of the electrochemical properties (towards dyes solar cells); Synthese de nanoparticules par chimie douce: controle structural, morphologique et dimensionnel. Etudes des proprietes electrochimiques (vers les cellules solaires a colorants)

    Energy Technology Data Exchange (ETDEWEB)

    Cassaignon, S.; Koelsch, M.; Jolivet, J.P. [Paris-6 Univ. Pierre et Marie Curie, Chimie de la Matiere Condensee de Paris, CNRS UMR 7574, 75 - Paris (France)

    2006-07-01

    In this work are described the electrochemical behaviour of different TiO{sub 2} films (anatase, brookite and rutile) in aqueous solution and the influence of the parameters as the crystal structure and the morphology on the electrochemical answer. To complete this study, the capacity of the double layer has been measured by impedance spectroscopy. Voltage measurements of TiO{sub 2} sensitized by a dye will allow to discuss the reversibility of the system and the rearrangement mechanisms. At last, the influence of the nature of the TiO{sub 2} particles (anatase, rutile and brookite) on the photovoltage has been studied in order to estimate their interest for photovoltaic devices. (O.M.)

  11. The fibroblast growth factor-2 (F.G.F.-2) expression predicts the tumoral response and the local of non at small cells bronchi cancers after chemoradiotherapy; L'expression de FGF-2 predit la reponse tumorale et le controle local des cancers bronchiques non a petites cellules apres chimioradiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Massabeau, C.; Toulas, C.; Moyal, E. [Institut Claudius-Regaud, 31 - Toulouse (France); Rouquette, I.; Lauwers-Cances, V.; Mazieres, J. [Centre Hospitalier Universitaire, 31 - Toulouse (France)

    2007-11-15

    The tumoral expression of the fibroblast growth factor-2 is correlated with a bad response to chemotherapy and a strong rate of local recurrence. F.G.F.-2 would define a radioresistant phenotype of non at small cells bronchi carcinoma. (N.C.)

  12. Study of feasibility of the preoperative chemoradiotherapy for stage 2B/3 non at small cells bronchi cancer and histological response: about 107 cases treated at Avignon; Etude de faisabilite de la chimioradiotherapie preoperatoire pour cancer bronchique non a petites cellules de stades 2B/3 et reponse histologique: a propos de 107 cas traites a Avignon

    Energy Technology Data Exchange (ETDEWEB)

    Pourel, N.; Hilgers, W.; Mineur, L.; Reboul, F. [Institut Sainte-Catherine, 84 - Avignon (France); Santelmo, N. [Centre Hospitalier H.-Duffaut, 84 - Avignon (France); Molinari, N. [Laboratoire de biostatistique, faculte de Medecine, 34 - Montpellier (France)

    2006-11-15

    The preoperative chemoradiotherapy is an induction treatment that is feasible for stage 2B/3 non at small cells for patients whom Who performance index is 0-1. The surgery is to question if a pneumonectomy, particularly right one, is necessary. The histological response to chemoradiotherapy is a factor of forecasting of the global survival. (N.C.)

  13. Study of the action of a phosphonate additive on steel scale deposit and corrosion in the hydrodynamic conditions of a channel flow cell; Etude de l'action d'un additif phosphone sur l'entartrage et sur la corrosion de l'acier dans les conditions hydrodynamiques d'une cellule a canal

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, C.

    2000-10-17

    In cooling systems, an improved control of scale deposit and corrosion processes is a major challenge and an realistic evaluation tool for water treatments is of the utmost economic importance. In this study, a channel flow cell was used to allow in-situ electrochemical measurements in well defined electrolyte tube flowing conditions. An expression of the mass transfer towards the electrode was established where the diffusion-limited current is a function of Re{sup 1/3} in the laminar regime and was verified experimentally using the redox couples Fe[CN]{sub 6}{sup 4-}/ Fe[CN]{sub 6}{sup 3-} and O{sub 2}/OH{sup -}. This hydrodynamically controlled experimental device was developed to investigate scale deposit processes and to evaluate scale inhibitor efficiency using a electrochemical quartz crystal microbalance. Experiments were performed on three different waters, at various flow rates and temperatures. The efficiency of a well known phosphonate (HEDP) was tested at different concentrations and an optimum concentration could be established (0.7 mg dm{sup -3}). The effect of additive injection during the scale formation as well as the influence of flow rate on the inhibiting efficiency were evaluated. The anti-scale additive was shown to be more effective in the turbulent regime. HEDP has shown a strong effect on inhibiting crystal growth and that affected the morphology of CaCO{sub 3} crystals. The HEDP effect on protecting carbon steel against corrosion was also studied in mineral water containing Ca{sup 2+} ions. It was found that anti-corrosion effect of HEDP is enhanced by the presence of calcium in solution and that is due to the formation of an HEDP-Ca{sup 2+} complex, which adsorbs onto the metallic surface and protects it from dissolution. (author)

  14. Follow-up of patients treated by erlotinib (Tarceval) for a non at small cells lung cancer by PET-F.D.G.: preliminary results; Suivi de patients traites par erlotinib (Tarceval) pour cancer bronchique non a petites cellules par TEP-FDG: resultats preliminaires

    Energy Technology Data Exchange (ETDEWEB)

    Vervueren, L.; Berthelot, C.; Rakotonirina, H.; Lacoeuille, F.; Cahouet Vannier, A.; Le Jeune, J.J.; Couturier, O. [Service de medecine nucleaire et biophysique, CHU d' Angers, (France)

    2009-05-15

    This study is in the frame of the evaluation of targeted therapies. Its principal objective is to provide information on the tumor metabolism evolution by PET-F.D.G. for patients treated for non at small cells bronchi carcinomas by erlotinib (Tarceval), an inhibitor of tyrosine kinase targeting the receptor to epidermal growth factor (E.G.F.). The secondary objectives are to evaluate at term, the interest of the PET-F.D.G. in the identification of responder patients and the early evaluation of the therapy response. (N.C.)

  15. 肺炎支原体感染对老年慢性阻塞性肺疾病急性发作及肺炎患者免疫功能的影响%Role of mycoplasma pneumoniae infection in exacerbated stage of COPD and on celluler immune system of community acquired pneumonia patients

    Institute of Scientific and Technical Information of China (English)

    邓朝胜; 陈美云; 林其昌; 吴可贵; 唐爱忠; 翁义锐

    2004-01-01

    目的探讨肺炎支原体感染(MP)对老年慢性阻塞性肺疾病(COPD)急性发作及社区获得性肺炎(肺炎)患者细胞免疫功能的影响. 方法 39例老年COPD急性发作、40例老年肺炎患者及30例老年健康对照者用ELISA法测定其血清MP特异性IgM、IgG抗体及干扰素-γ(IFN-γ)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)含量;通过聚合酶链式反应(PCR)法检测痰液中的MP. 结果 (1)COPD组MP PCR法及MP-IgM阳性率明显高于肺炎组及对照组(P<0.05);(2)COPD组IFN-γ含量明显低于肺炎组(P<0.01),而TNF-α含量则反之;(3)COPD、肺炎组MP-IgM阳性者IFN-γ含量明显低于组内MP-IgM阴性者(P<0.05). 结论 (1)老年人中COPD急性发作MP感染阳性率显著高于肺炎患者;(2)老年COPD急性发作患者IFN-γ水平明显低于老年肺炎患者,而TNF-α、IL-6水平则显著升高;(3)MP感染可能抑制了老年人COPD急性发作及肺炎患者IFN-γ的产生.

  16. Mediastinal radiotherapy after multidrug chemotherapy and prophylactic cranial irradiation in patients with SCLC - treatment results after long-term follow-up and literature overview; Radiotherapie mediastinale apres chimiotherapie et irradiation prophylactique de l'encephale chez des patients atteints d'un carcinome bronchique a petites cellules - Resultats et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, M.K.A.; Bloch, E.; Overbeck, T.; Wolff, H.A.; Hille, A.; Hess, C.F.; Christiansen, H. [Department of Radiotherapy, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Koerber, W. [Department of Pneumology, Weende Hospital, Section Lenglern, Pappelweg 5, 37120 Bovenden-Lenglern (Germany); Vorwerk, H. [Department of Hematology and Oncology, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Muller, M.; Pradier, O. [Department de cancerologie, CHU Morvan, 5, avenue Foch, 29200 Brest cedex (France)

    2011-04-15

    Introduction. - Curative therapy for patients with small-cell lung cancer (SCLC) is based on multidrug chemotherapy combinations and radiotherapy. After a long time follow-up, the aim of the study was to evaluate the efficacy and toxicity of sequential chemo-radiotherapy and the effect of prophylactic cranial irradiation (PCI). Methods. - From 1995-2005, 96 patients with SCLC (64 limited-disease [LD], 32 extensive-disease [ED]; median age 61 years [range 39-79]) were treated at our department with varying chemotherapy regimens and sequential mediastinal radiotherapy (50 Gy + 10 Gy boost in case of residual disease after chemotherapy). Afterwards, 15 patients with LD, good general condition and at least partial response after local treatment received PCI (30 Gy). Results. - After a median follow-up of 78.6 months, 20 patients remained alive (20.8%, median survival time 18.2 months). The 2-/5-year overall survival rates were 33.8% and 12.6%, the 2-/5-year loco-regional control rates were 30.3% and 24.5%, respectively. Distant metastases occurred in 43 patients (24 cerebral). Cerebral metastasis occurred in 6.7% and 27.2% of the patients with PCI and without PCI respectively. Only tumor stage showed a statistically significant impact on overall survival and loco-regional control in multivariate analysis. Radiotherapy was well tolerated. Grade 3/4 toxicity occurred in seven patients. Prognosis of patients with SCLC remains poor. Administration of PCI in selected patients bears a decrease in the incidence of cerebral metastases. Alternative chemotherapy schemes as well as irradiation schemes and techniques should be the substance of future randomized trials. (authors)

  17. Mouth ulcers

    Science.gov (United States)

    ... include: Canker sores Gingivostomatitis Herpes simplex ( fever blister ) Leukoplakia Oral cancer Oral lichen planus Oral thrush A ... chap 22. Read More Canker sore Cellulitis Gingivostomatitis Leukoplakia Lichen planus Mouth sores Oral cancer Tooth abscess ...

  18. Management of orbital complications of sinusitis in pediatric patients.

    Science.gov (United States)

    Kinis, Vefa; Ozbay, Musa; Bakir, Salih; Yorgancilar, Ediz; Gun, Ramazan; Akdag, Mehmet; Sahin, Muhammed; Topcu, Ismail

    2013-09-01

    The most common reason of orbital infections is sinusitis. Orbital complications of sinusitis are mostly seen in children. Loss of vision and intracranial infections are among the complications of sinusitis. Prompt diagnosis and treatment is very important in the management of orbital complications. The orbital complication can be in the form of cellulitis or abscess. A retrospective review of 26 pediatric patients with orbital complications due to sinusitis was presented in this study. Of 26 patients, there were 13 cases of preseptal cellulitis, 2 cases of orbital cellulitis, and 11 cases of subperiosteal abscess. We grouped the preseptal and orbital cellulites in one category and the subperiosteal abscess in the other. All patients in the cellulitis group recovered by medical treatment. All the patients were treated by surgical drainage. Early diagnosis and appropriate treatment method are vital for the treatment of orbital complications secondary to sinusitis.

  19. Omfalitis med fatal udgang hos en nyfødt dreng

    DEFF Research Database (Denmark)

    Debes, Nanette M M Mol; Dahl, Marianne; Jonsbo, Finn

    2008-01-01

    Omphalitis is a serious condition with important morbidity and mortality, especially in developing countries. The most commonly involved micro-organisms are Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. We describe a Danish patient with cellulitis...

  20. [Omphalitis with fatal outcome in new-born baby boy

    DEFF Research Database (Denmark)

    Debes, N.M.; Dahl, M.; Jonsbo, F.

    2008-01-01

    Omphalitis is a serious condition with important morbidity and mortality, especially in developing countries. The most commonly involved micro-organisms are Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. We describe a Danish patient with cellulitis...

  1. The use of differential scintigraphy in the clinical diagnosis of osseous and soft tissue changes affecting the diabetic foot

    Energy Technology Data Exchange (ETDEWEB)

    Visser, H.J.; Jacobs, A.M.; Oloff, L.; Drago, J.J.

    Prompt recognition of cellulitis, osteomyelitis, diabetic osteolysis, Charcot neuroarthropathy, septic synovitis, and deep plantar abscesses in the diabetic foot is essential because the therapy is drastically different. Differential diagnosis has been greatly facilitated by recently developed scanning techniques.

  2. InterProScan Result: FS936446 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 33 ER lumen protein retaining receptor Biological Process: protein retention in ER lumen (GO:0006621)|Cellul...ar Component: integral to membrane (GO:0016021)|Molecular Function: ER retention sequence binding (GO:0046923) ...

  3. InterProScan Result: FS784123 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 33 ER lumen protein retaining receptor Biological Process: protein retention in ER lumen (GO:0006621)|Cellul...ar Component: integral to membrane (GO:0016021)|Molecular Function: ER retention sequence binding (GO:0046923) ...

  4. SHEWANELLA AND PHOTOBACTERIUM IN OYSTERS AND SEAWATER FROM THE DELAWARE BAY

    Science.gov (United States)

    Shewanella algae, S. putrefaciens, and Photobacterium damselae subsp. damselae are indigenous marine bacteria and human pathogens causing cellulitis, necrotizing fasciitis, abscesses, septicemia, and death. Infections are rare and are most often associated with the immunocompromized host. A study ...

  5. Necrotizing soft tissue infection

    Science.gov (United States)

    Necrotizing fasciitis; Fasciitis - necrotizing; Flesh-eating bacteria; Soft tissue gangrene; Gangrene - soft tissue ... 2014:chap 137. Pasternack MS, Swartz MN. Cellulitis, necrotizing fasciitis, and subcutaneous tissue infections. In: Bennett JE, Dolin ...

  6. Staph Infections

    Science.gov (United States)

    ... Culture Household Safety: Preventing Cuts Dealing With Cuts Osteomyelitis Tetanus First Aid: Skin Infections Toxic Shock Syndrome ... Abscess Paronychia Dealing With Cuts and Wounds Cellulitis Osteomyelitis Impetigo Staph Infections MRSA Cuts, Scratches, and Scrapes ...

  7. Diabetic foot ulceration with osteomyelitis: the importance of early detection

    OpenAIRE

    Tranter, Jennifer; McIntosh, Caroline

    2008-01-01

    This case study explores the\\ud management of a chronic diabetic\\ud foot ulcer complicated by severe\\ud soft tissue infection (cellulitis) and\\ud bony infection (osteomyelitis) in a\\ud patient with type 2 diabetes.

  8. Bacterial Nasal Infections

    Science.gov (United States)

    ... vestibule. Nasal furuncles may develop into a spreading infection under the skin (cellulitis) at the tip of the nose. A doctor becomes concerned about infections in this part of the face because veins ...

  9. 75 FR 10165 - New Animal Drugs; Change of Sponsor

    Science.gov (United States)

    2010-03-05

    ... skin and soft tissue infections including cellulitis, pyoderma, dermatitis, wound infections, and... infections (cystitis) due to susceptible strains of Escherichia coli, Proteus mirabilis, and S. aureus. (ii) Cats. For the treatment of skin and soft tissue infections including abscesses, wound...

  10. Streptococcal Infections

    Science.gov (United States)

    ... red rash on the body. Impetigo - a skin infection Toxic shock syndrome Cellulitis and necrotizing fasciitis (flesh-eating disease) Group B strep can cause blood infections, pneumonia and meningitis in newborns. A screening test ...

  11. Erythema multiforme

    Science.gov (United States)

    ... liver (hepatitis) Permanent skin damage and scarring Skin infection ( cellulitis ) When to Contact a Medical Professional Go to ... 2009:chap 52. Read More Allergic ... Conditions Skin Infections Browse the Encyclopedia A.D.A.M., Inc. ...

  12. Scalded skin syndrome

    Science.gov (United States)

    ... Severe bloodstream infection ( septicemia ) Spread to deeper skin infection ( cellulitis ) When to Contact a Medical Professional Call your provider or go to the emergency room if you have symptoms of this disorder. Prevention ... Alternative Names Ritter disease; Staphylococcal ...

  13. Abscess

    Science.gov (United States)

    ... For Kids For Parents MORE ON THIS TOPIC Cellulitis Wound Healing and Care Peritonsillar Abscess Immune System Appendicitis Paronychia Staph Infections MRSA Contact Us Print Resources Send to a ...

  14. Lymphadenitis

    Science.gov (United States)

    ... Complications Untreated lymphadenitis may lead to: Abscess formation Cellulitis (a skin infection) Fistulas (seen in lymphadenitis that is due to ... infection. Alternative Names Lymph node infection; Lymph gland infection; Localized ... Protein in diet Sepsis Swollen lymph nodes ...

  15. An investigation of the possibility to replace the rabbit pyrogen test by an in vitro test

    NARCIS (Netherlands)

    Gommer AM; Donders LAM; LGM

    1998-01-01

    The classical test for the detection of pyrogenic contaminations in pharmaceuticals is the rabbit pyrogen test. The most frequently occuring and most important pyrogenic contamination in biological and biotechnological pharmaceutical preparations are bacterial endotoxins, originating from the cellul

  16. La genomica animale: biodiversità, qualità dei prodotti, salute umana e benessere animale

    OpenAIRE

    Biagini, Tommaso; Bueno, Susana; Chillemi, Giovanni

    2011-01-01

    La genomica è la disciplina scientifica che studia la struttura, la funzione e l’evoluzione del genoma di una specie. Questa scienza cerca di spiegare come sono programmate le cellule di individui diversi investigando l’intero patrimonio genetico. Inoltre studia anche cellule di uno stesso individuo le quali, pur avendo lo stesso genoma, possono avere forma e funzione molto differenti, come ad esempio un neurone ed una cellula di tessuto epatico. La comprensione delle complesse relazioni tra ...

  17. GENOMICA ANIMALE: BIODIVERSITÀ, QUALITÀ DEI PRODOTTI, SALUTE UMANA E BENESSERE ANIMALE

    OpenAIRE

    Bueno, Susana; Chillemi, Giovanni

    2012-01-01

    La genomica è la disciplina scientifica che studia la struttura, la funzione e l’evoluzione degli acidi nucleici di una specie a livello globale, appunto “genomico”. Questa scienza cerca di spiegare sia come siano programmate le cellule di individui diversi sia come cellule di uno stesso individuo, pur avendo lo stesso genoma, possano avere forma e funzione molto differenti (ad esempio un neurone e una cellula di tessuto epatico) sia come modificazionidel genoma possano comportare aberrazioni...

  18. La genomica animale: biodiversità, qualità dei prodotti, salute umana e benessere animale

    OpenAIRE

    Chillemi, Giovanni; Bueno, Susana; Prosperini, Gianluca; Mancini, Giordano

    2010-01-01

    La genomica studia struttura, funzione ed evoluzione del patrimonio genetico degli esseri viventi, cercando di spiegare come sono programmate le cellule di individui diversi, attraverso l’esplorazione dell’intero patrimonio genetico. Inoltre la genomica studia anche cellule di uno stesso individuo le quali, pur avendo lo stesso genoma, possono avere forma e funzione molto differenti, come ad esempio un neurone ed una cellula di fegato. La comprensione delle complesse relazioni che esistono tr...

  19. Studying a disease with no home--lessons in trial recruitment from the PATCH II study.

    LENUS (Irish Health Repository)

    Thomas, Kim S

    2010-01-01

    Cellulitis is a very common condition that often recurs. The PATCH II study was designed to explore the possibility of preventing future episodes of cellulitis, with resultant cost savings for the NHS. This was the first trial to be undertaken by the UK Dermatology Clinical Trials Network. As such, it was the first to test a recruitment model that involved many busy clinicians each contributing just a few patients.

  20. Infectious Complications of Noncombat Trauma Patients Provided Care at a Military Trauma Center

    Science.gov (United States)

    2010-05-01

    the median age was 38 and 22C’f \\\\ere female. Pulmonary infections were present 1n.f.2cr of pallenh. 2 40(- had cellulitis and wound infections ... infection , and celluliti ’> (Table Ill ). Cumulative pneumonia rates in trauma and burned ventilated patients, respecti\\ ely, are presented with...hospiwllengths of ’ltay (lOS>. and to die (p < 0.05). Multivariate analysis reve~lled associations between infection and hospital LOS. pree·\\isting

  1. La synthèse et l'évaluation cytotoxicité de dérivées triazolic contre des lignes de cellule de mélanome B16 et une méthodologie étudient sur la synthèse d'éthers propargyl de leur correspondance propargyl des esters sans catalyseur et sous des irradiations à micro-ondes

    OpenAIRE

    Kalhor Monfared, Shiva,

    2014-01-01

    Medicinal chemistry is the application of chemical research techniques to the synthesis of pharmaceuticals. During this PhD project, we tried to synthesize small molecules based on terminal alkyne and propargyl alcohols. These molecules were prepared by departing from a simple aldehyde and by doing reactions like Bestmann-Ohira in order to prepare terminal alkynes or reaction with ethynylmagnesium bromide to prepare propargyl alcoholsB. These prepared small molecules were then subjected into ...

  2. Méthode de synthèse de la structure des convertisseurs multi-niveaux

    OpenAIRE

    Bartholoméüs, P.; P. Le Moigne; Rombaut, C.

    1997-01-01

    Une méthode d'étude des structures de convertisseurs réalisés à partir de cellules multi-niveaux à association de sources de tension en série est présentée. La notion de non réversibilité en puissance de la cellule de commutation est introduite. Elle permet la définition des structures de conversion réversibles ou non réversibles. À partir du sens de circulation du courant dans les cellules, il est possible de définir la caractéristique statique des interrupteurs réalisant les connexions entr...

  3. Periorbital cellulits--a mistaken diagnosis!

    Science.gov (United States)

    Fozard, Julia; Pandya, Nikila; Pulikot, Ashok; Fish, David; Malhotra, Raman; Lake, Damian

    2011-08-17

    A 12-year-old girl presented with a 1 week history of orbital swelling associated with granuloma, purulent discharge from the eye and preauricular and submandibular lymphadenopathy. Initial conventional treatment for presumed preseptal cellulitis was unsuccessful. Despite treatment with broad spectrum antibiotics, the preseptal cellulitis progressed to orbital cellulitis with restriction of eye movements in addition to the marked conjunctival chemosis and haemorrhage. A detailed history revealed she had been in close contact with newborn kittens at home and biopsy of the granuloma demonstrated Bartonella species, confirming the diagnosis of cat scratch disease. The child received a course of appropriate oral and topical antibiotics and steroids. Unfortunately eyesight in the right eye remains poor on follow-up.

  4. Development of a Dynamic Biomechanical Model for Load Carriage: Phase III Part C1: Pressure and Force Distribution Measurement for the Design of Waist Belts in Personal Load Carriage Systems

    Science.gov (United States)

    2005-08-01

    d’étalonnage, qui dépendent de la surface efficace de la cellule et du coefficient de frottement utilisés pour l’orientation de chaque capteur sur place, ont...utilisant la surface utile des capteurs à cellules du TekscanMC et le coefficient de frottement longitudinal a été démontrée. Son application est...surface. Calibration factors, a factor of effective sensel area and a frictional coefficient for the in situ orientation of each sensor were calculated

  5. CANCER BRONCHO-PULMONAIRE ET thérapeutique

    OpenAIRE

    Chater, Asma

    2014-01-01

    Le cancer du poumon est une maladie caractérisée par une croissance incontrôlée des cellules dans les tissus du poumon. Si elle n'est pas traitée, cette croissance peut se propager au-delà du poumon dans un processus appelé métastase dans les tissus voisins et, éventuellement, dans d'autres parties du corps. La plupart des cancers qui commencent dans les poumons, connue sous le nom cancers du poumon primaires, sont des carcinomes qui dérivent de cellules épithéliales. Les principaux types de ...

  6. Des panneaux Solaires Haut Rendement

    OpenAIRE

    Adaine, Abdoulwahab

    2016-01-01

    National audience; Les cellules solaires sont généralement basées sur une seule jonction P-N et utilisent généralement le silicium sous forme cristalline comme matériau semi-conducteur. Ce pendant avec une seule jonction P-N, la cellule solaire ne peut tout simplement pas absorber la totalité du spectre solaire, et on se heurte donc à une limite maximale du rendement qui est d’environ 25%. Afin d'essayer de dépasser cette limite, les recherches se tournent vers l'utilisation d'autres matériau...

  7. Méthode de synthèse de la structure des convertisseurs multi-niveaux

    Science.gov (United States)

    Bartholoméüs, P.; Le Moigne, P.; Rombaut, C.

    1997-09-01

    In this paper a study of the multilevel converters' structures is presented. Multilevel cells with series connection of voltage sources are considered. The notion of power reversibility of the cell is introduced. It allows for the definition of reversible and non-reversible converter structures. The knowledge of the sign of the current which circulates in the cell permits the definition of the static characteristics of the switches involved in the connection between the different points of the voltage source and the current source. Two configurations of the cells are studied. For each one, the static characteristic of each switch is determined. For the first configuration, called “N_c-switch cell", each point of the voltage source is connected to the current source by one switch only. The second one is constituted of a stacking-up of switching elementary cells. It is called “elementary cell association structure". In this case, several switches are involved in each connection. Thanks to these two configurations, different cells have been developed, and they allow for the definition of new structures of rectifiers. Une méthode d'étude des structures de convertisseurs réalisés à partir de cellules multi-niveaux à association de sources de tension en série est présentée. La notion de non réversibilité en puissance de la cellule de commutation est introduite. Elle permet la définition des structures de conversion réversibles ou non réversibles. À partir du sens de circulation du courant dans les cellules, il est possible de définir la caractéristique statique des interrupteurs réalisant les connexions entre un des différents points de la source de tension et la source de courant. Deux trames d'interrupteurs sont considérées. Pour la première, nommée “cellule à N_c interrupteurs", les connexions sont réalisées par un seul interrupteur à la fois. Pour la seconde, constituée d'un empilage de cellules élémentaires de commutation, et nomm

  8. Rhinocerebral mucormycosis: Race against time for surgeons

    Directory of Open Access Journals (Sweden)

    G C Rajkumar

    2016-01-01

    Full Text Available Rhinocerebral mucormycosis is a rare, aggressive, and rapidly progressive life-threatening opportunistic infection affecting the immunocompromised patients. It manifests as facial swelling, cellulitis, nasal obstruction and discharge, large areas of tissue destruction and necrosis, orbital cellulitis, ptosis, proptosis, and vision loss in advanced cases. The pathognomonic feature of the disease is the presence of invasive mycelium in the tissues. A case series on four patients diagnosed with rhinocerebral mucormycosis is presented. Diabetic ketoacidosis was the common risk factor observed in all the three patients. It was concluded that early diagnosis and aggressive medical and surgical treatment are necessary for decreasing the high mortality rate of the infection.

  9. What Is Inflammatory Breast Cancer? Revisiting the Case Definition

    Science.gov (United States)

    2010-03-03

    d’orange 7 14% Warmth 6 12% Thick mass 3 6% Other 12 24% Initial clinical diagnoses for 10 women were infection , including nine diagnoses of mastitis...and one of cellulitis (Table 3). These 10 women were treated with antibiotic therapy for up to 5 months prior to a definitive diagnosis of breast...worry about 1 2% Fibrous mass 1 2% Cellulitis 1 2% Hematoma secondary to trauma 1 2% A discrete mass and thickening of the skin was the most

  10. Herida antebraquial infectada por Aeromonas hydrophila

    OpenAIRE

    1995-01-01

    Se presenta un caso de celulitis por Aeromonas hydrophila, en un paciente de 23 años, tras una herida antebraquial producida en el medio acuático. La celulitis se resolvió mediante desbridamiento agresivo y quimioterapia. En los controles posteriores no se han apreciado déficits funcionales tras la infección. A case of Aeromonas hidrophila cellulitis developped in a 23-year-old patient, after aquatic environment forearm wound is presented. His cellulitis was effectively resolve...

  11. Clothe the Soldier Prototype Modular Load Carriage System Design Assessment using the APLCS Load Carriage Simulator

    Science.gov (United States)

    2006-03-01

    hanches; pressions moyennes sur la peau , pressions de crête et forces sur l’avant et l’arrière des épaules, ainsi que le sac supérieur et inférieur...cellule dynamométrique tridimensionnelle au niveau des hanches; pressions moyennes sur la peau , pressions de crête et forces sur l’avant et l’arrière...personne; les forces et les moments par rapport à une cellule dynamométrique tridimensionnelle au niveau des hanches; pressions moyennes sur la peau

  12. Clothe the Soldier Prototype K1 Load Carriage System Design Assessment using the APLCS Load Carriage Simulator

    Science.gov (United States)

    2006-03-01

    une cellule dynamométrique tridimensionnelle à 6 degrés de liberté au niveau des hanches; pressions moyennes sur la peau , pressions de crête et...cellule dynamométrique tridimensionnelle à 6 degrés de liberté au niveau des hanches; pressions moyennes sur la peau , pressions de crête et forces sur...sur le plan vertical (z). La préoccupation principale concernant sa conception étaient les forces importantes appliquées sur la surface de la peau

  13. Increased Serum Levels of Epidermal Growth Factor in Children with Autism

    Science.gov (United States)

    Iseri, Elvan; Guney, Esra; Ceylan, Mehmet F.; Yucel, Aysegul; Aral, Arzu; Bodur, Sahin; Sener, Sahnur

    2011-01-01

    The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral…

  14. Linezolid and Rasagiline - A culprit for serotonin syndrome

    Directory of Open Access Journals (Sweden)

    Mohamed Hisham

    2016-01-01

    Full Text Available A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline.

  15. Quando il movimento è malato: la sclerosi laterale amiotrofica

    Directory of Open Access Journals (Sweden)

    Lucio Tremolizzo

    2011-09-01

    Full Text Available La sclerosi laterale amiotrofica (SLA è una malattia neurodegenerativa descritta dal celeberrimo neurologo francese Jean - Martin Charcot (Parigi 1825 - Nièvre 1893 sul finire del 1800. Il quadro è caratterizzato dal coinvolgimento selettivo del primo e del secondo motoneurone, le cellule che, convergendo sul muscolo (l’effettore finale, sono deputate all’espressione del movimento.

  16. Bacteroides isolated from four mammalian hosts lack host specific 16S rRNA gene phylogeny and carbon and nitrogen utilization patterns

    Science.gov (United States)

    Within the distal gut of mammals are trillions of microbes that utilize nutrients from diet, intestinal mucosa, and other gut microbes. One hundred three (103) isolates of B. ovatus, B. thetaiotaomicron, and B. xylanisolvens were recovered from cow, goat, human, and pig fecal enrichments with cellul...

  17. COMPARATIVE ASPECTS OF PLANT-CELL WALL DIGESTION IN INSECTS

    NARCIS (Netherlands)

    PRINS, RA; KREULEN, DA

    1991-01-01

    Although many phytophagous and wood-eating invertibrates form their own cellulases, there is an overwhelming variety of symbioses between plant- and wood-utilising insects and microorganisms. In one type of symbiosis (endosymbiosis), insects (rhinoceros beetle, cockroach, lower termites) host cellul

  18. Anti-Ro and anti-La autoantibodies induce TNF-α production by human salivary gland cells: an in vitro study

    Directory of Open Access Journals (Sweden)

    V. Mitolo

    2011-09-01

    Full Text Available Obiettivo: Lo scopo di questo studio è stato valutare la produzione di TNF-α, induttore della via estrinseca del processo apoptotico, in seguito al trattamento con gli autoanticorpi anti-Ro ed anti-La isolati da pazienti con sindrome di Sjögren primaria in un modello sperimentale rappresentato dalla linea cellulare di ghiandole salivari umane, A- 253. È stata, inoltre, valutata la presenza sulla superficie di tali cellule di recettori specifici per tale induttore, TNFR1 e TNFR2. Materiali e metodi: Gli autoanticorpi anti-La ed anti-Ro sono stati purificati su una colonna cromatografia ad alta affinità. Le metodiche utilizzate per la valutazione della produzione di TNF-α e lo studio dei recettori di superficie sono state immunofluorescenza, RT-PCR e saggi immunoenzimatici. Risultati: I nostri risultati hanno dimostrato che le cellule A-253 esprimono in superficie i recettori TNFR1 e TNFR2 e che gli autoanticorpi anti-Ro e anti-La sono in grado di indurre la produzione di TNF-α nelle stesse cellule. Conclusioni: Il trattamento con gli autoanticorpi anti-Ro ed anti-La induce la produzione di TNF-α in cellule di ghiandole salivari umane e questo potrebbe spiegare la attivazione della via estrinseca della apoptosi.

  19. Alternaria fungal dermatitis in a free-ranging javelina (Pecari tajacu).

    Science.gov (United States)

    Shender, Lisa A; Gerhold, Rick; Sanchez, Susan; Keel, M Kevin

    2011-07-01

    We report a javelina from Pinal County, Arizona, USA, with severe fungal dermatitis and cellulitis. Extreme emaciation and rostral disfiguration, including left-lateral displacement of the nasal planum, justified euthanasia. A pus-filled tract within the rostrum was observed. Histopathology revealed granulomatous inflammation with hyphae morphologically consistent with Alternaria sp. isolated by culture.

  20. Bone scintigraphy for neonatal osteomyelitis: simulation by extravasation of intravenous calcium

    Energy Technology Data Exchange (ETDEWEB)

    Balsam, D.; Goldfarb, C.R.; Stringer, B.; Farruggia, S.

    1980-04-01

    Intravenously administered calcium gluconate has become increasingly popular in the treatment of neonatal tetany. Occasionally, extravasation results in cellulitis, leading to a clinical diagnosis of superimposed osteomyelitis. Osseous scintigraphy, as the accepted modality in the early detection of osteomyelitis, would tend to be used in this circumstance. This case illustrates a false-positive result, probably due to soft-tissue calcification.

  1. Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia

    DEFF Research Database (Denmark)

    Vigano, A.; Ripamonti, M.; Palma, S. De;

    2008-01-01

    High altitude hypoxia is a paraphysiological condition triggering redox status disturbances of cell organization leading, via oxidative stress, to proteins, lipids, and DNA damage. In man, skeletal muscle, after prolonged exposure to hypoxia, undergoes mass reduction and alterations at the cellul......, whereas the mammalian target of rapamycin (mTOR), a marker of protein synthesis, was reduced Udgivelsesdato: 2008/11...

  2. Antimicrobial Prophylaxis in Adults

    OpenAIRE

    Enzler, Mark J.; Berbari, Elie; Osmon, Douglas R.

    2011-01-01

    Antimicrobial prophylaxis is commonly used by clinicians for the prevention of numerous infectious diseases, including herpes simplex infection, rheumatic fever, recurrent cellulitis, meningococcal disease, recurrent uncomplicated urinary tract infections in women, spontaneous bacterial peritonitis in patients with cirrhosis, influenza, infective endocarditis, pertussis, and acute necrotizing pancreatitis, as well as infections associated with open fractures, recent prosthetic joint placement...

  3. Mycobacterium fortuitum Infection following Reconstructive Breast Surgery: Differentiation from Classically Described Red Breast Syndrome

    Directory of Open Access Journals (Sweden)

    Orlando J. Cicilioni, Jr, MD, FACS

    2013-10-01

    Conclusions: When presented with possible RBS, surgeons must rule out cellulitis, culture for acid-fast bacilli such as mycobacterium species, and then determine the best course of treatment. Patient counseling regarding potential household sources of infection is warranted to minimize postoperative infection risk.

  4. Strangulated umbilical hernia in a child.

    OpenAIRE

    1983-01-01

    We describe a case of strangulated umbilical hernia in a girl aged 5 years. She presented with an acute inflammatory lesion at the umbilicus which was initially thought to be due to cellulitis with possible abscess formation. Exploration revealed an umbilical hernia containing necrotic greater omentum.

  5. Disseminated Soft Tissue Infection and Sepsis with Stenotrophomonas maltophilia in a Bone Marrow Transplant Patient

    Directory of Open Access Journals (Sweden)

    Jeffrey H Lipton

    1996-01-01

    Full Text Available A 32-year-old female presented with aplastic anemia and subsequently underwent a one-antigen mismatched bone marrow transplant from her brother. She failed to engraft and a second graft was attempted. Protracted neutropenia of three months’ duration despite the use of broad spectrum antibiotics occurred. Stenotrophomonas (Xanthomonas maltophilia metastatic cellulitis developed that did not respond to appropriate antibiotics.

  6. Roseomonas gilardii infection: case report and review.

    Science.gov (United States)

    Shokar, Navkiran K; Shokar, Gurjeet S; Islam, Jamal; Cass, Alvah R

    2002-12-01

    Roseomonas gilardii is a bacterium that has been indicated as a rare cause of human infections. The case of a patient presenting with cellulitis and bacteremia secondary to R. gilardii is described together with the clinical characteristics of infection with this organism obtained from a review of cases previously reported.

  7. Immune ThrombocytoPenia (ITP) secondary to Chronic Lymphoproliferative Disorders (LPDs) | EU Clinical Trials Register [EU Clinical Trials Register

    Lifescience Database Archive (English)

    Full Text Available ome complicanza della malattia linfoproliferativa (linfoma o leucemia linfatica c...do la classificazione WHO del 2008: piccolo linfoma linfocitico/leucemia linfatica cronica, linfoma follicol...are, linfoma della zona marginale, linfoma a cellule del mantello, linfoma linfoplasmacellulare, leucemia a

  8. Emergency War Surgery: Third United States Revision

    Science.gov (United States)

    2004-01-01

    soft tissue infection, such as clostridial gas gangrene or necrotizing fasciitis . Systemic effects such as fever, leukocytosis, unexplained...streptococcal, and clostridial species. These infections include wound abscess, cellulitis, septic arthritis, osteomyelitis, necrotizing fasciitis , and...clostridial infection. Crepitus, radiographic evidence of soft-tissue gas, epidermal blistering, and/or epidermal necrosis are the hallmarks of necrotizing

  9. Journal of Special Operations Medicine. Volume 2, Edition 4, Fall 2002

    Science.gov (United States)

    2002-01-01

    clostridial myonecrosis must encompass other gas-forming infections, including necrotizing fasciitis , streptococ- cal myositis, acute streptococcal...REFERENCES 1. Riseman J, Zamboni W, Curtis A, et al: Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the need for...hemolytic gangrene, crepitant cellulitis, and synergistic necrotizing celluli- tis. The crepitance should be differentiated from other causes of

  10. Integrated Multimodal Imaging of Dynamic Bone-Tumor Alterations Associated with Metastatic Prostate Cancer

    NARCIS (Netherlands)

    Brisset, Jean-Christophe; Hoff, Benjamin A.; Chenevert, Thomas L.; Jacobson, Jon A.; Boes, Jennifer L.; Galban, Stefanie; Rehemtulla, Alnawaz; Johnson, Timothy D.; Pienta, Kenneth J.; Galban, Craig J.; Meyer, Charles R.; Schakel, Timothy; Nicolay, Klaas; Alva, Ajjai S.; Hussain, Maha; Ross, Brian D.; Schakel, Tim

    2015-01-01

    Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellul

  11. Linezolid and Rasagiline - A culprit for serotonin syndrome

    OpenAIRE

    Mohamed Hisham; Mundalipalayam N Sivakumar; Nandakumar, V; S Lakshmikanthcharan

    2016-01-01

    A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline.

  12. Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders

    NARCIS (Netherlands)

    Baker, Darren J.; Wijshake, Tobias; Tchkonia, Tamar; LeBrasseur, Nathan K.; Childs, Bennett G.; van de Sluis, Bart; Kirkland, James L.; van Deursen, Jan M.

    2011-01-01

    Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellul

  13. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

    NARCIS (Netherlands)

    Baker, D.J.; Wijshake, T.; Tchkonia, T.; LeBrasseur, N.K.; Childs, B.G.; Sluis, B. van de; Kirkland, J.L.; Deursen, J.M.A. van

    2011-01-01

    Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellul

  14. Extraintestinal Vibrio infections in Mauritius.

    Science.gov (United States)

    Issack, Mohammad I; Appiah, Deoraz; Rassoul, Ameen; Unuth, Mahesswaree N; Unuth-Lutchun, Nehma

    2008-10-01

    Few extraintestinal Vibrio infections have been reported in the African region. We report 3 cases from Mauritius: one case of Vibrio alginolyticus otitis externa; one case of soft tissue infection caused by non-O1 Vibrio cholerae and Vibrio parahaemolyticus; and one fatal case of non-O1 V. cholerae cellulitis and septicaemia.

  15. 38 CFR 17.272 - Benefits limitations/exclusions.

    Science.gov (United States)

    2010-07-01

    ...) Intraoral abscess when it extends beyond the dental alveolus. (vi) Extraoral abscess. (vii) Cellulitis and... necessary to perform the function of the human lens, lost as a result of intraocular surgery, ocular injury... requiring a prescription, except for insulin and related diabetic testing supplies and syringes....

  16. Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum

    NARCIS (Netherlands)

    Van Der Zee, Maurijn; Benton, Matthew A.; Vazquez-Faci, Tania; Lamers, Gerda E M; Jacobs, Chris G C; Rabouille, Catherine

    2015-01-01

    In insects thefertilized egg undergoes a series of rapid nuclear divisions before the syncytial blastoderm starts to cellularize. Cellularization has been extensively studied in Drosophila melanogaster but its thick columnar blastoderm is unusual among insects.We therefore set out to describe cellul

  17. A non-travel related rash in a traveler

    Directory of Open Access Journals (Sweden)

    Keith A. Sacco

    2017-01-01

    Full Text Available A 45-year-old man was admitted for investigation of a symmetric lower limb rash associated with recurrent fever for two weeks following a hiking trip in Italy and Greece. He was treated for sepsis secondary to lower limb cellulitis with no clinical improvement and subsequently diagnosed with Streptococcus gallolyticus endocarditis mediating an infectious vasculitis.

  18. To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture

    NARCIS (Netherlands)

    Willmann, Charlotte A; Hemeda, Hatim; Pieper, Lisa A; Lenz, Michael; Qin, Jie; Joussen, Sylvia; Sontag, Stephanie; Wanek, Paul; Denecke, Bernd; Schüler, Herdit M; Zenke, Martin; Wagner, Wolfgang

    2013-01-01

    Induced pluripotent stem cells (iPSCs) are usually clonally derived. The selection of fully reprogrammed cells generally involves picking of individual colonies with morphology similar to embryonic stem cells (ESCs). Given that fully reprogrammed cells are highly proliferative and escape from cellul

  19. InterProScan Result: FS918167 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS918167 FS918167_2_ORF1 D5AE1121C885716E PANTHER PTHR15314 RIBONUCLEASE P PROTEIN ...SUBUNIT P20 2.5e-30 T IPR014612 unintegrated Molecular Function: ribonuclease P activity (GO:0004526)|Cellul

  20. Acute lymphangitis in a preschool child: A case report

    Directory of Open Access Journals (Sweden)

    Loh Huai Seng

    2012-12-01

    Full Text Available A 3-year old preschool boy presented with apruritic red streak at the dorsum of his right foot travelingupward from the affected site which was red and swollen.Insect sting was the more likely trigger which had causedthe cellulitis and subsequently the acute lymphangitis.

  1. Contingency Contracting: A Framework for Reform

    Science.gov (United States)

    2010-05-14

    medical sick-call records showed 38 cases that an attending medical official said could be attributed to water, such as skin abscesses, cellulitis ...skin infections , and diarrhea. (Report No. D-2008-060) DCMA inspected the M2 gun parts at the contractor’s facility and inappropriately approved

  2. Endoscopic component separation for ventral hernia causes fewer wound complications compared to open components separation

    DEFF Research Database (Denmark)

    Jensen, Kristian K; Henriksen, Nadia A; Jorgensen, Lars N

    2014-01-01

    -analysis reporting on a total of 163 patients. Patient demography and the rates of mesh repair were comparable between the ECS and OCS patient groups. The incidence of wound complications comprising surgical site infection, skin necrosis, subcutaneous abscess, seroma, skin dehiscence, cellulitis, and fistula...

  3. Caratterizzazione di alterazioni molecolari relative alla patogenesi delle Neoplasie Mieloproliferative Croniche

    OpenAIRE

    Bogani, C

    2009-01-01

    Il primo obiettivo dello studio è stato di chiarire il ruolo svolto dal sistema CXCR4-SDF1 nella abnorme circolazione di cellule CD34+ nei pazienti con PMF. Il secondo obiettivo dello studio è stato di analizzare il coinvolgimento della pathway PI3K/AKT/mTOR nella deregolazione funzionale dei progenitori ematopoietici di pazienti con Policitemia Vera e Mielofibrosi Primaria.

  4. Caracterisation thermique de modules de refroidissement pour la photovoltaique concentree

    Science.gov (United States)

    Collin, Louis-Michel

    Pour rentabiliser la technologie des cellules solaires, une reduction du cout d'exploitation et de fabrication est necessaire. L'utilisation de materiaux photovoltaiques a un impact appreciable sur le prix final par quantite d'energie produite. Une technologie en developpement consiste a concentrer la lumiere sur les cellules solaires afin de reduire cette quantite de materiaux. Or, concentrer la lumiere augmente la temperature de la cellule et diminue ainsi son efficacite. Il faut donc assurer a la cellule un refroidissement efficace. La charge thermique a evacuer de la cellule passe au travers du recepteur, soit la composante soutenant physiquement la cellule. Le recepteur transmet le flux thermique de la cellule a un systeme de refroidissement. L'ensemble recepteur-systeme de refroidissement se nomme module de refroidissement. Habituellement, la surface du recepteur est plus grande que celle de la cellule. La chaleur se propage donc lateralement dans le recepteur au fur et a mesure qu'elle traverse le recepteur. Une telle propagation de la chaleur fournit une plus grande surface effective, reduisant la resistance thermique apparente des interfaces thermiques et du systeme de refroidissement en aval vers le module de refroidissement. Actuellement, aucune installation ni methode ne semble exister afin de caracteriser les performances thermiques des recepteurs. Ce projet traite d'une nouvelle technique de caracterisation pour definir la diffusion thermique du recepteur a l'interieur d'un module de refroidissement. Des indices de performance sont issus de resistances thermiques mesurees experimentalement sur les modules. Une plateforme de caracterisation est realisee afin de mesurer experimentalement les criteres de performance. Cette plateforme injecte un flux thermique controle sur une zone localisee de la surface superieure du recepteur. L'injection de chaleur remplace le flux thermique normalement fourni par la cellule. Un systeme de refroidissement est installe

  5. Oxti-photo-battery: utilization of new oxygenated titanium polymers for the elaboration of thin photoactive films by sol-gel techniques. Realization of photovoltaic cells exempt from photo sensitizer and development of photo batteries. Concerted actions energy (PE1). Final report. July 2004; Oxti-photobatterie: Utilisation de nouveaux polymeres oxygenes du titane pour l'elaboration de films minces photoactifs par des techniques sol-gel. Realisation de cellules photovoltaiques exemptes de photosensibilisateurs et developpement de photobatteries. Action concertee energie (PE1). Rapport final. Juillet 2004

    Energy Technology Data Exchange (ETDEWEB)

    Brohan, L. [Laboratoire de Chimie des Solides, 44 - Nantes (France); Nunzi, J.M. [Angers Univ., Laboratoire des Proprietes Optiques des Materiaux et Applications, 49 - Angers (France)

    2004-07-01

    This coordinated project aims to elaborate new photovoltaic cells realized from a photosensitive titanium gel, called ''TiDMF''. This inorganic polymer, presents interesting optical properties: it takes a bleu color (by reduction of the Ti{sup 4+} in Ti{sup 3+}), after exposition to the day light. This particularity allows the realization of solar cells exempt from photo sensitizer. (A.L.B.)

  6. L'(E)TABLISSEMENT D'UN MOD(E)LE CELLULAIRE DE L'OLIGONUCL(E)OTIDE MUTANT

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objectif Pour établir un modèle cellulaire de l'oligonucléotide mutant. Méthodes Par rapport la prise du gène de la protéine de fluorescence verte et agrandisse (EGFP), nous induissons une mutation par la technique du point mutant de PCR pour changer du codon de 98ème position du gène egfp GAA au codon d' arrêt TAA , formant le gène egfp-D de mutant, donc on construit deux vecteurs de plasmides : pcDNA3-egfp et pcDNA3-egfp-D. Puis les plasmides sont transférés dans les cellules NIH-3T3 par le calcium de phosphate. Résultats Sous le microscope de fluorescence, on n'a pas vu l'expression de la EGFP dans tous les cellules transférées par l' egfp-D de mutant, et en même temps, les cellules transférées par l'egfp normal peuvent exprimer la EGFP. Ensuite on obtient les cellules stables par le criblage de G418. PCR confirme l'intégration du gène egfp-D dedans le génome ADN des cellules. RT-PCR et Northern blot analysent les gènes egfp et egfp-D peuvent transcrire normalement, il montre les cellules transférées par le gène egfp-D de mutant n'exprimant pas la fluorescence verte est parce que la traduction est terminée en avant. Conclusion Le modèle cellulaire de l'oligonucléotide mutant rapporté par le gène egfp est établi avec succès, ce modèle peut employer en recherche du système réparant thérapeutique via le chimeric ARN /ADN oligonucléotide (RDOs).

  7. Pelvic Surgical Site Infections in Gynecologic Surgery

    Directory of Open Access Journals (Sweden)

    Mark P. Lachiewicz

    2015-01-01

    Full Text Available The development of surgical site infection (SSI remains the most common complication of gynecologic surgical procedures and results in significant patient morbidity. Gynecologic procedures pose a unique challenge in that potential pathogenic microorganisms from the skin or vagina and endocervix may migrate to operative sites and can result in vaginal cuff cellulitis, pelvic cellulitis, and pelvic abscesses. Multiple host and surgical risk factors have been identified as risks that increase infectious sequelae after pelvic surgery. This paper will review these risk factors as many are modifiable and care should be taken to address such factors in order to decrease the chance of infection. We will also review the definitions, microbiology, pathogenesis, diagnosis, and management of pelvic SSIs after gynecologic surgery.

  8. Cervical celullitis in broiler chickens for Escherichia coli/ Celulite cervical em frangos de corte causada por Escherichia coli

    Directory of Open Access Journals (Sweden)

    Ivens Gomes Guimarães

    2002-05-01

    Full Text Available In this paper was report the isolation of Escherichia coli in broiler chickens with cellulitis in the cervical region. It was carried through the isolation of E. coli of the lesion of cellulitis from broilers and carried through histopathological examination of skin that had characterized the lesion. Focal ulcerations of epidermis, fibrin in dermis and difuse infiltrated by lymphocytes and heterophils on subcutaneous tissues.Neste trabalho, relata-se o isolamento de Escherichia coli em frangos de corte apresentando lesão de celulite na região cervical. Foi realizado o isolamento de E. coli da lesão de celulite e realizado exames histopatológicos que caracterizaram a lesão. Na epiderme foram verificadas lesões ulcerativas, presença de fibrina na derme e infiltração difusa de linfócitos e heterófilos no tecido subcutâneo.

  9. Vasculotoxic snake bite presenting with sepsis, acute renal failure, disseminated intravascular coagulation, and acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Vikram Bhausaheb Vikhe

    2013-01-01

    Full Text Available Vasculotoxic snake bites are well known to cause local complications like necrosis and cellulitis and systemic complications such as coagulopathy, acute renal failure (ARF, and hemolysis. We report a case of young female patient who was bitten by a viper. She developed cellulitis, sepsis, ARF, and Disseminated Intravascular Coagulation. She was treated for the above complications and all her renal and hematological parameters returned to normal on seventh day. After this, on the same day, patient developed Acute Respiratory Distress Syndrome probably due to the direct toxic effect of venom on pulmonary vascular endothelium which has been reported as a late complication of snake venom. With close monitoring and proper management of complications, the patient recovered and walked out of the hospital on the twenty first day without any complications.

  10. Morganella morganii in sinonasal region: A rare case report

    Directory of Open Access Journals (Sweden)

    Haşmet Yazıcı

    2013-09-01

    Full Text Available Morganella morganii is a gram negative pathogen andmay cause potentially lethal disease especially in patientswith underlying or immunosuppressive disease. It is commonlyfound in long-term urinary catheter used and immunesystem deficiency patients as nosocomial disease.Involving other systems such as skin, skeletal systemand central nervous system can be seen too. Sporadicoccurrence is rare and can be seen in any system by variouscauses like AIDS, snake bites and poisoning. In thiscase we present sporadic Morganella morganii infectionon sinonasal region with the presence of sinusitis, sinocutaneousfistula, preseptal cellulitis and hard palate defecton 58 year old male diabetic patient. Microbiologicalassessment from open wound and sinuses were reportedas Morganella morganii. To our knowledge, this is the firstcase of sino-nasal Morganella morganii infection with sino-cutaneous fistula, preseptal cellulitis and maxillofacialbone destruction. J Clin Exp Invest 2013; 4 (3: 383-386Key words: Morganella Morganii, sino-nasal fistula, preseptalcellulitis, bone destruction

  11. Mesure par conductimetrie de la receptivite aux maladies fongiques et du niveau de resistance induite par elicitation. Etude sur 3 modeles experimentaux

    OpenAIRE

    Molot, P.M.; Mas, P.; Pivot, V; Bruneteau, M; Staron, T; Ferriere, H.; Lemaire, J.M.

    1992-01-01

    L’appréciation des dégâts parasitaires, souvent difficile à évaluer, peut être effectuée par des mesures conductimétriques; en effet, les cellules altérées libèrent davantage d’électrolytes que les cellules saines dans le milieu extérieur, dont on mesure la conductance. Cette méthode peut être utilisée dans différents cas, notamment lorsqu’il y a attaque au niveau racinaire. On mesure alors la conductance de l’eau dans laquelle baignent des racines contaminées (piment - Phytophthora capsici, ...

  12. Radionuclide imaging in the evaluation of osteomyelitis and septic arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, E.E.; Haynie, T.P.; Podoloff, D.A.; Lowry, P.A.; Harle, T.S. (Univ. of Texas M.D. Anderson Hospital, Houston (USA))

    1989-01-01

    Despite controversy over its exact role, radionuclide imaging plays an important role in the evaluation of patients suspected of having osteomyelitis. The differentiation between osteomyelitis and cellulitis is best accomplished by using a three-phase technique using Tc-99m methylene diphosphonate (MDP). Frequently, it is necessary to obtain multiple projections and magnification views to adequately assess suspected areas. It is recommended that a Ga-67 or In-111 leukocyte scan be performed in those cases where osteomyelitis is strongly suspected clinically and the routine bone scan is equivocal or normal. Repeated bone scan after 48 to 72 h may demonstrate increased radioactivity in the case of early osteomyelitis with the initial photon-deficient lesion. In-111 leukocyte imaging is useful for the evaluation of suspected osteomyelitis complicating recent fracture or operation, but must be used in conjunction with clinical and radiographic correlation. The recognition of certain imaging patterns appears helpful to separate osteomyelitis from septic arthritis or cellulitis. 83 references.

  13. Orbital abscess secondary to acute dacryocystitis: case report Abscesso orbitário secundário à dacriocistite aguda: relato de caso

    Directory of Open Access Journals (Sweden)

    Marcia Clivati Martins

    2008-08-01

    Full Text Available Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac can extend to the orbital contents resulting in orbital cellulitis. We present a case of intraconal abscess secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection.A dacriocistite aguda comumente evolui para infecção pré-septal. Raramente a infecção localizada no saco lacrimal pode estender-se ao conteúdo orbitário resultando em celulite orbitária. Apresentamos um caso de abscesso orbitário intraconal secundário à dacriocistite aguda e uma revisão de literatura de celulite orbitária causada por infecção aguda do saco lacrimal.

  14. Proteomica degli exosomi urinari per la ricerca di biomarcatori nella nefropatia diabetica e nelle tubulopatie ereditarie

    OpenAIRE

    Corbetta,

    2015-01-01

    Le urine costituiscono il fluido biologico di elezione nella ricerca di biomarcatori per le patologie renali in quanto possono essere raccolte in modo semplice e non invasivo; una strategia per la semplificazione del proteoma urinario è rappresentata dall’isolamento degli exosomi urinari (UE), nanovescicole di membrana (30-100 nm) rilasciate dalle cellule epiteliali nello spazio urinario. In questo lavoro abbiamo focalizzato l’attenzione sulla nefropatia diabetica (DN), una comune complicazio...

  15. Green House Gas Control and Agricultural Biomass for Sustainable Animal Agriculture in Developing Countries

    OpenAIRE

    Takahashi, J.

    2010-01-01

    Important green house gases (GHG) attributed to animal agriculture are methane (CH4) and nitrous oxide (N2O), though carbon dioxide (CO2) contributes almost half of total greenhouse effect. Rumen CH4 production in an enteric fermentation can be accounted as the biggest anthropogenic source. Some of prebiotics and probiotics have been innovated to mitigate rumen CH4 emission. The possible use of agricultural biomass consisted of non-edible parts of crop plants such as cellulose and hemi cellul...

  16. The Cubooctahedron Shape—A Suboptimal Cell Shape for 3—Dimensional Cellular System

    Institute of Scientific and Technical Information of China (English)

    ChaGuangming; LiZhengmao; 等

    1995-01-01

    This paper shows a celluler concept for three-dimensional(3-D)case.A new concept of base station lattice(BSL)and co-channel reuse lattice(CCRL)is proposed.A new method of se-lecting the cell shape for 3-D,sphere covering,is explored.From the comparision between the cu-bic cell and the body-centered-cubic(BCC)cell,the cubooctahedron shape -BCC cell is the most e-conomic one.

  17. Cost Effectiveness Analysis of Hygiene-Based Strategies Aimed Toward Prevention of SSTI and MRSA-Associated SSTI Among U.S. Active Duty Army Trainees

    Science.gov (United States)

    2015-03-25

    resistance to oxacillin). The final multivariate negative binomial regression model showed clinical outcomes (microbiology and syndrome ); initial care (MRSA...clinical care (MRSA coverage); syndrome (abscess-cellulitis-like diagnosis); and microbiology (clinical culture). Variable selection into the model was...Services Inc.) 20:161-7 148. Mott PJ, Sisk BW, Arbogast JW, Ferrazzano-Yaussy C, Bondi CA, Sheehan JJ. 2007. Alcohol-based instant hand sanitizer use in

  18. Sequential evolution of bacterial morphology by co-option of a developmental regulator

    OpenAIRE

    Jiang, Chao; Brown, Pamela J.B.; Ducret, Adrien; Brun, Yves V

    2014-01-01

    What mechanisms underlie the transitions responsible for the diverse shapes observed in the living world? While bacteria display a myriad of morphologies 1 , the mechanisms responsible for the evolution of bacterial cell shape are not understood. We investigated morphological diversity in a group of bacteria that synthesize an appendage-like extension of the cell envelope called the stalk 2,3 . The location and number of stalks varies among species, as exemplified by three distinct sub-cellul...

  19. The Effect of Formaldehyde Fixation on RNA: Optimization of Formaldehyde Adduct Removal

    OpenAIRE

    2011-01-01

    Formalin-fixed, paraffin-embedded tissues generally provide low yields of extractable RNA that exhibit both covalent modification of nucleic acid bases and strand cleavage. This frustrates efforts to perform retrospective analyses of gene expression using archival tissue specimens. A variety of conditions have been reported to demodify formaldehyde-fixed RNA in different model systems. We studied the reversal of formaldehyde fixation of RNA using a 50 base RNA oligonucleotide and total cellul...

  20. MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma

    Institute of Scientific and Technical Information of China (English)

    Cameron; M; Smith; David; I; Watson; Michael; Z; Michael; Damian; J; Hussey

    2010-01-01

    Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellul...

  1. Localizzazione della topoisomerasi IB sui telomeri di S. cerevisiae e ruolo della sua attività catalitica sulle modificazioni istoniche

    OpenAIRE

    Russo, Alessandra

    2007-01-01

    Il superavvolgimento del DNA nelle cellule, regolato dalle DNA Topoisomerasi, influenza molti processi biologici, quali la trascrizione, la replicazione, la ricombinazione ed il rimodellamento della cromatina. La DNA Topoisomerasi IB eucariotica, (Top1), è un enzima efficiente nella rimozione dei superavvolgimenti del DNA in vitro e la sua principale funzione cellulare è la rimozione dei superavvolgimenti positivi e negativi generati durante la trascrizione e la replicazione. ...

  2. The Air Force Global Reach Laydown (GRL): Using the Estimating Supplies Program to Validate Clinical Requirements

    Science.gov (United States)

    2006-01-11

    279 Epididymitis, Cystitis, Prostatitis, Orchitis , Including Testicular Torsion, All Cases B-7 Appendix B. Global Reach Laydown List of Patient...Medicine Objectives B-9 PC Number Patient Condition Description 328 Animal Bites and Rabies Exposure 329 Trachoma All Cases 330 Schistosomiasis...Cellulitis Involving Face or Weight Bearing Areas 2.5298 3 234 Bronchitis Acute All Cases 2.3568 3 279 Epididymitis, Cystitis, Prostatitis, Orchitis

  3. Orbital complications secondary to acute sinusitis– A 10 years retrospective review

    OpenAIRE

    2015-01-01

    Abstract Introduction: Orbital complication may accompany acute sinusitis in all age, commonly preseptal or orbital cellulitis. Aim: To evaluate the clinical presentation, management, and outcome of orbital complications of sinusitis in patients treated at our institution. Methods: A case study of retrospective review of 10 patients with orbital complications secondary to acute sinusitis was conducted in our centre over a 10-years period. The clinical presentation, relevant investigations, m...

  4. GRK2 svolge un ruolo cruciale nella regolazione della funzione endoteliale in vivo ed in vitro attraverso la modulazione del signaling del recettore β2-adrenergico

    OpenAIRE

    Liccardo, Daniela

    2013-01-01

    Il recettore β-2 adrenergico (β2AR), che rappresenta il sottotipo più abbondante nei vasi sanguigni, gioca un ruolo cruciale nella funzioni delle cellule endoteliali (EC) in quanto ne regola la migrazione e la proliferazione con importanti implicazioni sulla neoangiogenesi in vivo. In seguito ad ischemia periferica i recettori β2AR sono fortemente downregolati e la loro overespressione, mediante terapia genica, è in grado di incrementare l’angiogenesi in risposta all’ischemia. La chinasi 2 de...

  5. Ingegneria del tessuto cardiaco: strategie sperimentali per la riparazione del danno miocardico irreversibile in un modello animale

    OpenAIRE

    Alfano, Antonia

    2011-01-01

    La ricerca nel campo dell'ingegneria tissutale applicata alla patologia cardiaca ha compiuto notevoli progressi negli ultimi anni,numerosi studi in vivo ed in vitro ne attestano le notevoli potenzialità terapeutiche. In questo studio abbiamo esaminato l’efficacia di scaffold a base di collagene di tipo I per il trapianto di cellule cardiache in un modello animale di infarto miocardico. Il disegno sperimentale ha previsto l’isolamento di cardiomiociti neonatali di ratto, i quali sono stati suc...

  6. Epidemiology of Podiatric Injuries in U.S. Marine Recruits Undergoing Basic Training

    Science.gov (United States)

    1992-01-01

    presenting to the dispensary were screened by a Ingrown toenail 703.00 68 0.29Lower leg strain 844.90 61 0.26 corpsman for referral to the Podiatry Clinic...Fractures 4.7%• [ Cellulitis U Tinea Pedis 5.51/o6 Contusions El Plantar Fasciitis 8.7% 17.7% Tenosynovitis *1 Strains E Ingrown Toenails 0 Blisters

  7. Påvising og karakterisering av PGE2 reseptorar med omsyn på regulering av matriks metalloproteinasar frå osteosarkomcellelinjer

    OpenAIRE

    Oma, Hildegunn

    2007-01-01

    Enkelte kroniske inflammatoriske sjukdommar er kjent å disponere for utvikling av kreft. Ettersom fleire COX-2 hemmarar har synt kjemoterapeutisk effekt er det skapt stor interesse kring PGE2 si generelle rolle, og relevans i høve til kreft. PGE2 regulerer ei rekkje cellulære prosessar gjennom binding til fire prostaglandin E reseptorar (EP reseptorar). Matriks metalloproteinsar (MMPar) er ei gruppe enzym som er vist å vere involvert mellom anna ved tumorinvasjon, metastasering og angiogense....

  8. Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins

    OpenAIRE

    2016-01-01

    Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers w...

  9. Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed After Segmental Mastectomy

    Science.gov (United States)

    2005-07-01

    follow-up in a randomized clinical Preliminary clinical results and dose-volume histogram anal - trial comparing total mastectomy with lumpectomy with or...18 months. ity included breast edema, hematoma, arm edema cellulitis, King et al conducted a prospective phase I/JI study of skin necrosis, abscess ...The poor skin-to-device spacing. Complications included seromas locoregional control rate was 100% in each arm and the 3- (3 of 43) and abscess

  10. Notes from the field: Contamination of alcohol prep pads with Bacillus cereus group and Bacillus species--Colorado, 2010.

    Science.gov (United States)

    2011-03-25

    In October 2010, a child at The Children's Hospital (TCH) in Aurora, Colorado, with newly diagnosed leukemia developed clinical sepsis 24 hours after insertion of an implanted vascular access device. The child also developed extensive cellulitis at the insertion site, requiring surgical debridement, intensive care, antibiotics, prolonged wound management, and outpatient treatment. Cultures of the child's blood and tissue specimens grew Bacillus cereus. An investigation found neither breach of infection control procedures nor any violations of sterile surgical technique.

  11. Myroides odoratimimus soft tissue infection in an immunocompetent child following a pig bite: case report and literature review

    Directory of Open Access Journals (Sweden)

    Sofia Maraki

    2012-08-01

    Full Text Available Members of the genus Myroides are aerobic Gram-negative bacteria that are common in environmental sources, but are not components of the normal human microflora. Myroides organisms behave as low-grade opportunistic pathogens, causing infections in severely immunocompromised patients and rarely, in immunocompetent hosts. A case of Myroides odoratimimus cellulitis following a pig bite in an immunocompetent child is presented, and the medical literature on Myroides spp. soft tissue infections is reviewed.

  12. Proteine chiave dei processi metabolici indotti dall’acido indolo-3-acetico (IAA) in Rizobio

    OpenAIRE

    2006-01-01

    I batteri del suolo gram-negativi dei generi Rhizobium, Bradyrhizobium, Azorhizobium, Mesorhizobium e Sinorhizobium, collettivamente chiamati rizobi, sono microrganismi azotofissatori simbionti delle radici delle Leguminose. Nel processo di simbiosi i rizobi inducono la divisione cellulare delle cellule corticali della radice con la formazione dei cosiddetti noduli radicali, all’interno dei quali i batteroidi, ossia i batteri differenziati, riducono l’azoto atmosferico ad ammonio (P. van Rhij...

  13. BIOSYNTHESIS OF BACTERIAL CELLULOSE BY МEDUSOMYCES GISEVII

    OpenAIRE

    E. K. Gladysheva; E. A. Skiba

    2015-01-01

    Summary: Bacterial cellulose is an organic material that is synthesized by microorganisms extracellularly. Bacterial cellulose can be used in various industries. Especially, bacterial cellulose has found its application basically in medicine. The production of bacterial cellulose is a complicated and long process. The principal criterion for the process to be successful is bacterial cellulose to be obtained in a higher yield. Russia is lacking an operating facility to produce bacterial cellul...

  14. Musculoskeletal infections: ultrasound appearances

    Energy Technology Data Exchange (ETDEWEB)

    Chau, C.L.F. [Department of Radiology, North District Hospital, NTEC, Fanling, NT, Hong Kong (China)]. E-mail: c8681@yahoo.com; Griffith, J.F. [Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, NTEC, Shatin, NT, Hong Kong (China)

    2005-02-01

    Musculoskeletal infections are commonly encountered in clinical practice. This review will discuss the ultrasound appearances of a variety of musculoskeletal infections such as cellulitis, infective tenosynovitis, pyomyositis, soft-tissue abscesses, septic arthritis, acute and chronic osteomyelitis, and post-operative infection. The peculiar sonographic features of less common musculoskeletal infections, such as necrotizing fasciitis, and rice body formation in atypical mycobacterial tenosynovitis, and bursitis will also be presented.

  15. Improvement of a Clinical Score for Necrotizing Fasciitis: 'Pain Out of Proportion' and High CRP Levels Aid the Diagnosis.

    Science.gov (United States)

    Borschitz, Thomas; Schlicht, Svenja; Siegel, Ekkehard; Hanke, Eric; von Stebut, Esther

    2015-01-01

    Necrotizing fasciitis (NF) is a rare mono-/polymicrobial skin infection that spreads to underlying tissues. NF is quickly progressing and leads to life threatening situations. Immediate surgical debridement together with i.v. antibiotic administration is required to avoid fatal outcome. Early diagnosis is often delayed due to underestimation or confusion with cellulitis. We now compared the initial clinical and laboratory presentation of NF and cellulitis in detail to assess if a typical pattern can be identified that aids timely diagnosis of NF and avoidance of fatal outcome. 138 different clinical and laboratory features of 29 NF patients were compared to those of 59 age- and gender matched patients with severe erysipelas requiring a subsequent hospitalization time of ≥10 days. Differences in clinical presentation were not obvious; however, NF patients suffered significantly more often from strong pain. NF patients exhibited dramatically elevated CRP levels (5-fold, p>0.001). The overall laboratory risk indicator for necrotizing fasciitis (LRINEC) score was significantly higher in NF patients as compared to cellulitis. However, a modification of the score (alteration of laboratory parameters, addition of clinical parameters) led to a clear improvement of the score with a higher positive predictive value without losing specificity. In summary, clinical differentiation of NF from cellulitis appears to be hard. 'Pain out of proportion' may be an early sign for NF. An improvement of the LRINEC score emphasizing only relevant laboratory and clinical findings as suggested may aid the early diagnosis of NF in the future leading to improvement of disease outcome by enabling rapid adequate therapy.

  16. Combined endovascular treatment of aorto-oesophageal fistula with mediastinitis

    Science.gov (United States)

    Berna, Pascal; Pequignot, Aurélien; De Temmerman, Pierre; De Dominicis, Florence

    2013-01-01

    False aortic aneurysm is an uncommon complication after oesophageal perforation and results in a high rate of mortality. A 63-year-old patient presented with acute chest pain. Biochemical tests (cardiac enzymes) and electrocardiogram were normal. A thoracic and abdominal CT scan was performed, and showed a foreign body in the posterior mediastinum, with mediastinal cellulitis and a false aortic aneurysm. Surgical endovascular management was performed, with stenting of the thoracic aorta and oesophageal exploration. PMID:23042800

  17. A 52 Kilodalton Protein Vaccine Candidate for Francisella tularensis

    Science.gov (United States)

    2004-12-01

    du vaccin vivant F. tularensis (LVS). Soixante pourcent (60%) des souris vaccindes ont survdcu la dose ltale multiple alors que toutes les souris non...le lysat des cellules de cultures vivantes du vaccin vivant F. tularensis. Plusieurs composants de Francisella tularensis ont dt6 identifids par cet...antiserum. Le s6rum de souris provenant de souris vaccin6es avec F. tularensis non- vivant n’a pas identifid ces composants. A partir de ces prot6ines

  18. Down syndrome: a risk factor for mycotic aneurysm?

    LENUS (Irish Health Repository)

    Naughton, Peter A

    2011-03-29

    Down syndrome, or trisomy 21, has a characteristic constellation of clinical findings, including various congenital heart defects. We report a case of an adult male with Down syndrome who presented with a 3-week history of lower limb pain and swelling, attributed to cellulitis. Clinical and angiographic evaluation identified a below-knee mycotic pseudoaneurysm secondary to infective endocarditis. Surgical aneurysmal repair and revascularization were performed. Various management options are outlined in this report.

  19. Seven-year survival after pancreaticoduodenectomy for early recurrent renal cell carcinoma involving the duodenum A case report.

    Science.gov (United States)

    Cannistra', Marco; Ruggiero, Michele; Bonaiuto, Elisabetta; Vaccarisi, Sebastiano; Naso, Agostino; Grande, Raffaele; Nardo, Bruno

    2015-12-29

    Il cancro del rene rappresenta la 13a forma di tumore a livello mondiale e risulta incrementata, dal punto di vista epidemiologico, di circa il 2% annuo nelle ultime due decadi. Studi recenti hanno mostrato un numero complessivo di 65,150 nuovi casi di cancro renale diagnosticato nei paesi occidentali e circa 13.680 morti. Il carcinoma a cellule renali rappresenta approssimativamente il 90% di tutte le forme di cancro renale e presenta un tasso di mortalità di circa 4 soggetti ogni 100000 abitanti per anno. Il carcinoma a cellule renali ha, spesso, un particolare corteo sintomatologico caratterizzato da dolore addominale, masse addominali ed ematuria. Caratteristico è il fatto che circa il 25-30% dei pazienti, all’atto della diagnosi, presentano già metastasti a distanza; un ulteriore 30-50%, inoltre, svilupperanno metastasi nel corso della malattia, anche dopo molti anni dall’operazione chirurgica di nefrectomia radicale. Il Cancro del Rene a Cellule Chiare metastatizza in genere per via linfatica, ematogena, transperitoneale o per invasione diretta, ed i siti di metastasi più comuni sono il polmone ed i linfonodi, seguiti dalle ossa e dal fegato. Tra tutte le possibili localizzazioni ai segmenti addominali, il duodeno rappresenta la sede meno colpita: quando coinvolta, viene, in genere, invasa la regione periampollare ed il bulbo del duodeno. Tali localizzazioni danno segno di sè, spesso tardivamente, con sanguinamenti (ematemesi) o ostruzioni del tratto gastrointestinale superiore (vomito). Il nostro caso clinico descrive un carcinoma a cellule renali che si presentava, dopo soli 5 mesi dalla nefrectomia radicale destra, con sanguinamento del tratto gastrointestinale superiore e metastasi a carico del duodeno, e che è stato trattato chirurgicamente con duodenocefalopancreasectomia. L’intervento chirurgico, noto per essere altamente demolitivo ed associato ad elevata morbilità, applicato a recidiva precoce di cancro, ha garantito un ottimo risultato

  20. CT evaluation of soft tissue and muscle infection and inflammation: A systematic compartmental approach

    Energy Technology Data Exchange (ETDEWEB)

    Beauchamp, N.J. Jr. [Dept. of Radiology, and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, MD (United States); Scott, W.W. Jr. [Dept. of Radiology, and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, MD (United States); Gottlieb, L.M. [Dept. of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD (United States); Fishman, E.K. [Dept. of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD (United States)

    1995-07-01

    This essay presents a systematic approach to the evaluation of soft tissue and muscle infection by defining the various pathologic processes and then illustrating them through a series of CT studies with corresponding schematic diagrams. The specific processes discussed are cellulitis, lymphangitis/lymphedema, necrotizing fascitis, myositis/myonecrosis, and abscess. Key points in the differential diagnosis of these entities are discussed and illustrated. The clinical management of the specific pathologic processes is also discussed. (orig./MG)

  1. Pott′s puffy tumor following an insect bite

    Directory of Open Access Journals (Sweden)

    Raja V

    2007-01-01

    Full Text Available Pott′s puffy tumor, a feature of osteomyelitis of the frontal bone, is a rare entity, especially in adults. Sir Percival Pott originally described this condition as a complication of trauma to the frontal bone. This is also a recognized complication of fronto-ethmoidal sinusitis. We present a rare case of Pott′s puffy tumor caused by an insect bite presenting initially as a preseptal cellulitis and explore its pathogenesis and management.

  2. Radionucleotide scanning in osteomyelitis

    Energy Technology Data Exchange (ETDEWEB)

    Sachs, W.; Kanat, I.O.

    1986-07-01

    Radionucleotide bone scanning can be an excellent adjunct to the standard radiograph and clinical findings in the diagnosis of osteomyelitis. Bone scans have the ability to detect osteomyelitis far in advance of the standard radiograph. The sequential use of technetium and gallium has been useful in differentiating cellulitis and osteomyelitis. Serial scanning with technetium and gallium may be used to monitor the response of osteomyelitis to antibiotic therapy.

  3. Post-traumatic osteomyelitis due to aeromonas species

    Directory of Open Access Journals (Sweden)

    Gunasekaran L

    2009-01-01

    Full Text Available We report a case of Aeromonas osteomyelitis due to injury in a sewage worker. He presented with cellulitis of the left foot. Radiographs showed evidence of osteomyelitis involving the head and neck of the fifth metatarsal. Aeromonas species was isolated from the tissue and swab from the foot. The head and neck of the fifth metatarsal were excised and the patient improved on 4 weeks of intravenous meropenem followed by 4 weeks of oral clindamycin and ciprofloxacin.

  4. Possible phase transitions probed by infrared spectroscopy under high pressure: BiTeI and Li0.9Mo6O17

    OpenAIRE

    Tran, Michaël

    2014-01-01

    Ce travail de thèse porte sur la spectroscopie optique dans le cas où l’échantillon se trouve dans une cellule de haute pression et à basse température. La mise en place de ce dispositif expérimental a permis l’étude de deux composés : BiTeI et Li0.9Mo6O17.

  5. Introduction to Views of Connectivism Theory of Learning

    OpenAIRE

    2016-01-01

    ‘Traditional’ theories of learning as pratical dimensions of psychology majorly tend to focus their interest on humans’ inner factors that influence the process of learning such as intelligences, motivation, interest, attitude, concentration and aptitude. They never connect it with instruments and technological inventions such as multimedia, cyber celluler, internet, even social organization, cultural values, traditions etc., while these are very influential nowdays towards the progress and b...

  6. Sequestrating giant complex odontoma: a case report and review of the literature.

    Science.gov (United States)

    Perumal, C J; Mohamed, A; Singh, A; Noffke, C E E

    2013-12-01

    Odontomas are the most common benign tumours of odontogenic origin. Due to their hamartomatous nature, they are usually asymptomatic but can cause impaction of one or more teeth. They consist microscopically of all the tissue types found in a developed tooth. We present a case of a large sequestrating complex odontoma resulting in facial asymmetry, cellulitis, pain and partial loss of function. This case has significance, as odontomas of this large size have rarely been reported.

  7. Risk Factors Associated with Diagnoses of Heterotopic Ossification in Recent Combat Amputees

    Science.gov (United States)

    2009-07-22

    infection 20/69 (29%) 82/313 (26%) Osteomyelitis 22/69 (32%) 62/313 (20%)* Cellulitis 18/69 (26%) 51/313 (16%) Amputation stump...several complications: osteomyelitis, infections , deep vessel thrombosis, and pulmonary embolism. Conclusions: The present study extended previous...complications13-23, such as infections , phantom limb syndrome, deep vessel thrombosis, and pulmonary embolism have not received systematic study as possible

  8. Ocular sparganosis from Assam

    Science.gov (United States)

    Nath, Reema; Gogoi, Rajendra Nath

    2015-01-01

    Sparganosis is caused by plerocercoid larvae of the Pseudophyllidea tapeworms of the genus Spirometra. Though prevalent in East Asian and south east Asian countries like China, Japan, Korea, Taiwan, Vietnam, Thailand; yet very few cases are reported from India. We report a case of migrating sub-conjunctival ocular sparganosis mimicking scleritis which later on developed into orbital cellulitis from Dibrugarh, Assam, North-eastern part of India. This case is reported for its rarity. PMID:25709957

  9. Analisi d'immagine, patologia quantitativa e dimensione frattale in patologia veterinaria: Densita' e forme

    OpenAIRE

    Bianco, Carlo

    2015-01-01

    Fino dagli albori della metodica scientifica, l’osservazione e la vista hanno giocato un ruolo fondamentale. La patologia è una scienza visiva, dove le forme, i colori, le interfacce e le architetture di organi, tessuti, cellule e componenti cellulari guidano l’occhio del patologo e ne indirizzano la scelta diagnostico-classificativa. L’osservazione del preparato istologico in microscopia ottica si attua mediante l’esame e la caratterizzazione di anomalie ad ingrandimenti progressivamente cre...

  10. Selective purging of human multiple myeloma cells from autologous stem cell transplant grafts using oncolytic myxoma virus

    OpenAIRE

    Bartee, Eric; Chan, Winnie S.; Moreb, Jan S.; Cogle, Christopher R.; McFadden, Grant

    2012-01-01

    Autologous stem cell transplantation (ASCT) and novel therapies have improved overall survival of patients with multiple myeloma; however, most patients relapse and eventually succumb to their disease. Evidence indicates that residual cancer cells contaminate autologous grafts and may contribute to early relapses after ASCT. Here, we demonstrate that ex vivo treatment with an oncolytic poxvirus called myxoma virus results in specific elimination of human myeloma cells by inducing rapid cellul...

  11. Nõela all : Igakuine vinüülitutvustus / DJ Drummie

    Index Scriptorium Estoniae

    DJ Drummie

    1999-01-01

    Plaatidest Sandy Rivera feat. LT Brown "Come Into My Room", Deep Sensation "Somehow, Shomewhere (Soul Heaven)", Brothers of Soul "Eyes of Love", Dr.Gary Henry "'Faith", Royal Palm "Hecho En Inglaterra", La Cellule "Sweet Entourage EP", Antonio "Hyperfunk", DJ Paco & Terry Laird feat. MC Adrian "M.U.G. EP vol 1", DJ Brockie & Ed Solo "Represents/Shodown", Fresh and Vegas "Otto's Way/ Heatwave"

  12. Orbital Inflammation Developing from Epidemic Keratoconjunctivitis in an Adult

    Directory of Open Access Journals (Sweden)

    Sung In Kim

    2013-08-01

    Full Text Available Introduction: We report a rare case of epidemic keratoconjunctivitis (EKC that developed into an orbital inflammation in an adult. Case Presentation: A 67-year-old Korean man, who had been diagnosed with EKC and treated for conjunctival injection and chemosis in the right eye for 4 days, was referred to Oculoplastics as orbital cellulitis was suspected. At the point of referral, clinical features such as decreased visual acuity, severe eyelid swelling, chemosis, follicles, corneal edema, limitations in lateral eye movement, and diplopia were observed in the right eye. Orbital cellulitis was suspected according to orbital computed tomography scan images, but there was no response to systemic antibiotics. Systemic steroid was administered instead, and then his symptoms and signs started to improve. The final diagnosis of this patient was orbital inflammation related to EKC based on the facts that there was no response to antibiotics, that he presented with contralateral symptoms and signs, that pseudomembrane formation occurred in both eyes, and that the symptoms resolved completely after 2 weeks. Conclusion: Clinicians need to consider the possibility of orbital inflammation developing from EKC, even in an adult patient, and treat the patient properly if the EKC symptoms and signs, such as conjunctival injection and follicles, are accompanied with symptoms and signs similar to orbital cellulitis.

  13. Orbital cellulits following cataract surgery under peribulbar anaesthesia

    Directory of Open Access Journals (Sweden)

    Mukherjee, Chandoshi

    2015-01-01

    Full Text Available [english] Introduction: Orbital cellulits following cataract surgery is extremely rare. We describe a case of orbital and facial cellulitis that occurred after routine cataract operation with peribulbar anaesthesia. There were no preoperative systemic or ocular risk factors for postoperative infection. Case description: An 89-year-old man presented to eye casualty, the day after he underwent an uneventful phacoemulsification and posterior chamber lens implantation in the left eye under peribulabr anaesthesia, with soreness, swelling and reduced visual acuity (6/18 in the operated eye. On initial presentation periorbital swelling was noted, the eye was minimally tender, intraocular pressure was raised at 28 mHg and fundoscopy was limited due to a hazy cornea. The patient was discharged on topical medication with a diagnosis of allergic reaction to postoperative drops.The following day, the patient re-presented with worsening orbital swelling involving the left cheek. Ocular findings remained unchanged. CT scan revealed left orbit soft tissue swelling and a locule of air medial to the medial rectus. There were no signs of sinus infection or periosteal inflammation. A diagnosis of left orbital and facial cellulitis was made and the patient was treated with intravenous antibiotics.Discussion: Our patient did not have any predisposing risk factors, therefore most likely cause of cellulitis is surgical trauma during administration of the peribulbar block. This case illustrates the need for adequate skin preparation before the administration of peribulbar anaesthesia and minimal tissue trauma during the procedure.

  14. Studying a disease with no home - lessons in trial recruitment from the PATCH II study

    Directory of Open Access Journals (Sweden)

    Thomas Kim S

    2010-03-01

    Full Text Available Abstract Background Cellulitis is a very common condition that often recurs. The PATCH II study was designed to explore the possibility of preventing future episodes of cellulitis, with resultant cost savings for the NHS. This was the first trial to be undertaken by the UK Dermatology Clinical Trials Network. As such, it was the first to test a recruitment model that involved many busy clinicians each contributing just a few patients. Methods A double-blind randomised controlled trial comparing prophylactic antibiotics (penicillin V with placebo tablets, for the prevention of repeat episodes of cellulitis of the leg. Primary outcome was time to subsequent recurrence of cellulitis. Results The PATCH II study was closed to recruitment having enrolled 123 participants from a target of 400. Whilst the recruitment period was extended by 12 months, it was not possible to continue beyond this point without additional funds. Many factors contributed to poor recruitment: (i changes in hospital policy and the introduction of community-based intravenous teams resulted in fewer cellulitis patients being admitted to hospital; ii those who were admitted were seen by many different specialties, making it difficult for a network of dermatology clinicians to identify suitable participants; and iii funding for research staff was limited to a trial manager and a trial administrator at the co-ordinating centre. With no dedicated research nurses at the recruiting centres, it was extremely difficult to maintain momentum and interest in the study. Attempts to boost recruitment by providing some financial support for principal investigators to employ local research staff was of limited success. Discussion The model of a network of busy NHS clinicians all recruiting a few patients into large clinical studies requires further testing. It did not work very well for PATCH II, but this was probably because patients were not routinely seen by dermatologists, and recruitment

  15. Use of potassium-42 in the study of kidney functioning; Emploi du patassium-12 pour l'etude du fonctionnement renal

    Energy Technology Data Exchange (ETDEWEB)

    Morel, F.; Guinnebault, M. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    Following an intravenous injection of potassium-42 as indicator, an analysis of the specific activity vs. time curve in arterial plasma, in venous plasma efferent from the kidney, in urine and in various regions of the kidney of rabbits reveals that: 1) The turnover rate of potassium in the cortex cells (proximal and distal convoluted tubes) is very large, being limited only by renal blood flow. 2) The turnover rate of potassium in deep regions (Henle loops and collector tubules) is much smaller. 3) Potassium in the urine comes from cells of the convoluted tubes and not from cells of Henle loops, collector ducts, or glomerular filtrate. 4) Any potassium filtered at the level of the glomerules would be entirely reabsorbed at the level of the proximal tube, while total potassium in the urine results from a process of excretion by cells of the distal tube. These results are comparable with the assumption that the movement of potassium between interstitial medium and convoluted tube cells results from entirely passive processes. (author) [French] Apres injection intraveineuse au lapin de radiopotassium comme indicateur, l'analyse des courbes de la radioactivite specifique du potassium, mesuree en fonction du temps dans le plasma arteriel, dans le plasma veineux efferent du rein, dans l'urine et dans diverses regions du rein, lui-meme, permet de montrer: 1)que la vitesse de renouvellement du potassium contenu dans les cellules du cortex (tubes contournes proximaux et distaux), apparait tres grande et semble limitee par le debit sanguin renal. 2) que le vitesse de renouvellement du potassium contenu dans les regions profondes (anses de Henle et tubes collecteurs) est beaucoup plus faible. 3) que le potassium de l'urine a pour precurseur le potassium des cellules des tubes contournes et non celui des cellules des anses de Henle ou des canaux collecteurs, ni celui du filtrat glomerulaire. 4) que le potassium filtre au niveau des glomerules serait entierement

  16. Deep Neck Infections of Odontogenic Origin and Their Clinical Significance. A Retrospective Study from Hradec Králové, Czech Republic

    Directory of Open Access Journals (Sweden)

    Hana Doležalová

    2015-12-01

    Full Text Available Introduction: Cellulitis remains a very serious disease even today. Mortality, which varied between 10–40%, has been reduced owing to the standard securing of airway patency and use of an appropriate surgical treatment approach. Materials and methods: A total of 195 patients were hospitalised for cellulitis at the University Hospital in Hradec Králové during 2007–2011. The following parameters were evaluated: age, gender, dependence of incidence of the disease on the season of the year, frequency of attacks of the particular areas and their clinical characteristics, aetiology of the inflammation, types of patient complaints, prevalence of current systemic diseases, results of microbiological and selected laboratory analyses, socio-economic status of the patients, and duration of patient stay at the hospital. Statistical analysis was performed by using Pearson’s correlation coefficient, the statistical significance level was p < 0.05. Results: The mean age of the patients was 39.8 years. The group of 195 patients included 108 (55% males and 87 (45% females. The mean time between the first symptoms of the disease and admission to the Department was 5 days. From among the 195 patients, 116 (59.5% were working persons, 79 (40.5% were non-working (children, students, unemployed persons, women on maternity leave, retired people. The odontogenic origin of the disease was verified in 173 (88.7% patients. In total, 65 (33.3% patients had no coinciding complicating systemic disease, 22 (11.3% patients had diabetes mellitus. The most frequent symptom of cellulitis was painful swelling, found in 194 (99.5% patients, followed by jaw contracture, found in 153 (78.5% patients. Conclusion: The results are largely very similar to those of previous studies performed in other countries, except that we found no correlation between the prevalence of cellulitis and the socio-economic status, nor have we confirmed Klebsiella pneumoniae sp. as the cause of

  17. Expression and localization of aromatase during fetal mouse testis development.

    Science.gov (United States)

    Borday, Caroline; Merlet, Jorge; Racine, Chrystèle; Habert, René

    2013-01-01

    Les androgènes et les oestrogènes sont indispensables au développement et aux fonctions du testicule. Le testicule est particulièrement sensible aux perturbateurs endocriniens pendant le développement fœtal et beaucoup de perturbateurs endocriniens agissent en modifiant la balance oestrogènes/androgènes. Physiologiquement, cette balance est régulée par une cascade enzymatique qui convertit irréversiblement les androgènes en oestrogènes. Le composant principal de cette cascade est le cytochrome p450 19A1 (appelé couramment aromatase). Le but de ce travail a été d’étudier l’expression de l’aromatase testiculaire au cours du développement fœtal chez la souris.En utilisant une approche par RT-PCR et par western blot, nous avons montré que l’aromatase est exprimée dès 12,5 jours post-conception (jpc) et que l’expression est maximum à 17,5 jpc. Deux transcripts tronqués ont également été détectés par RT-PCR. La localisation cellulaire de l’aromatase a été étudiée par immunohistologie et par immunomarquage après séparation des cellules testiculaires. Cette enzyme est très fortement exprimée dans les cellules de Leydig fœtales. Elle est également exprimée dans les gonocytes mais plus faiblement et à un niveau variable selon les cellules. En revanche, elle est indétectable dans les cellules de Sertoli.En conclusion, cette étude montre pour la première fois chez la souris que 1) l’aromatase est exprimée dès le début de l’ontogenèse testiculaire, 2) elle est exprimée dans les gonocytes suggérant que ces cellules interviennent dans l’endocrinologie testiculaire et que le rapport oestrogènes/androgènes est plus important dans les gonocytes que dans le liquide interstitiel. En outre, on sait que, chez le fœtus de rat l’aromatase est essentiellement exprimée par les cellules de Sertoli. Nous proposons de prendre en compte cette différence inter-espèces comme un nouveau concept pour comprendre les diff

  18. Emerging extra-intestinal infections with Aeromonas hydrophila in coastal region of southern Karnataka

    Directory of Open Access Journals (Sweden)

    Mukhopadhyay C

    2008-01-01

    Full Text Available Background: Aeromonas species are gram-negative rods usually isolated from the gastrointestinal tract. They have been occasionally reported as a cause of extra-intestinal infections such as cellulitis, cholangitis, necrotizing fascitis, meningitis, bacteremia, or peritonitis in both immunocompetent and immunocompromised patients . Aim: To determine the role and possible pathogenesis of Aeromonas in extra-intestinal infections.Settings and Design: Retrospective analysis carried out at Kasturba Hospital Manipal, Karnataka in the months of January and February 2007. Materials and Methods: Clinical manifestations and management of eight cases of extra-intestinal infections caused by A. hydrophila , from the south Karnataka coastal region were reviewed. The isolates were identified with the help of biochemical tests using standard guidelines.Results: All patients acquired Aeromonas infections in the community. Five (62.5% had underlying illnesses, such as liver disease, diabetes mellitus or malignancy. Five (62.5% had polymicrobial infections, and three (37.5% were complicated with bacteremia. These included three patients with ulcers or abscess over the lower leg, two with cellulitis due to snake bite and one each with pelvic inflammatory disease, spontaneous bacterial peritonitis and pneumonia. A. hydrophila was found to be a causative agent of pelvic inflammatory disease or cellulitis following sea snake bite, and such a clinical scenario has not been previously described. Seven patients survived the illness. Conclusions: Isolation of A. hydrophila from extra-intestinal specimens demands utmost clinical and microbiological vigilance in diagnosis, since the organism can cause serious infections among immunocompromised as well as immunocompetent individuals.

  19. Evaluation of Ultrasonography as a Diagnostic Tool in Maxillofacial Space Infections

    Directory of Open Access Journals (Sweden)

    Praveen Kumar Pandey

    2011-11-01

    Full Text Available Objectives: The purpose of the study was to establish the role of ultrasonography in determining the involvement of specific fascial spaces in maxillofacial region and the stage of infection, in indicating the appropriate time for surgical intervention and to compare clinical and ultrasonographic findings.Material and Methods: Twenty five patients with fascial space infection in maxillofacial region were subjected to ultrasonographic examination following a detailed clinical and radiological examination. Ultrasonography guided needle aspiration was performed. Based on the findings, patients diagnosed with abscess were subjected to incision and drainage and those with cellulitis were subjected to medical line of treatment.Results: More than one fascial space was involved in all patients. On clinical examination 64 spaces were involved, of them 34 spaces had abscess formation and 30 spaces were in the stage of cellulitis. On ultrasonography examination, 28 spaces were reported to have abscess formation and 36 spaces were diagnosed to be in the stage of cellulitis. On comparative analysis of both clinical and ultrasonographic findings, ultrasonography was found to be sensitive in 65% of the cases and having specificity of 80%. It was registered statistically significant (P < 0.001 agreement between these two methods of assessment (kappa index = 0.814.Conclusions: Ultrasonography is a quick, widely available, relatively inexpensive, and painless procedure and can be repeated as often as necessary without risk to the patient. Thus ultrasonography is a valuable diagnostic aid to the oral and maxillofacial surgeon for early and accurate diagnosis of fascial space infection, their appropriate treatment and to limit their further spread.

  20. 新生儿继发于筛窦炎的眼眶脓肿%Orbital abscess secondary to ethmoidal sinusitis in neonates

    Institute of Scientific and Technical Information of China (English)

    C D Che Mahiran; K Wan Mariny; J Alagaratnam; W H Wan Hazabbah

    2008-01-01

    A subperiosteal abscess is a form of orbital cellulitis characterized by a collection of fluid and pus confined by the periosteal lining of the orbit. In neonates, orbital abscesses are extremely rare. We present a case of a 26-day-old baby girl with severe orbital cellulitis in the right eye. A computed tomography (CT) scan of the orbits and paranasal sinuses revealed right orbital cellulitis with medial subperiosteal and retro-orbital abscess. The growth of Staphylococcus aureus was found in eye discharges. The patient was started on intravenous ceftriaxone and intravenous metronidazole. Urgent drainage of the abscess was performed via functional endoscopic sinus surgery (FESS). She recovered well after intravenous antibiotics and surgical drainage. Surgical drainage via endoscopic technique is the preferred treatment to prevent further complications.%骨膜下脓肿是眼眶蜂窝织炎的一种,以脓和渗出液汇集在眼眶内骨膜下为特点.对于新生儿,眼眶脓肿非常罕见.我们报告1例年龄为26d的右眼患有严重眼眶蜂窝织炎的女患儿.眼眶和副鼻窦CT扫描显示右眼眶蜂窝织炎并内侧骨膜下和眼眶后部脓肿.眼分泌物培养见葡萄球菌生长,经用先锋霉素和甲硝唑静脉注射和经内窥镜鼻窦手术行急诊脓肿引流,恢复良好.通过内窥镜的鼻窦引流手术是预防更严重的并发症的首选治疗.

  1. Role of adipose-derived stem cells in chronic cutaneous wound healing.

    Science.gov (United States)

    Caruana, Giorgia; Bertozzi, Nicolò; Boschi, Elena; Pio Grieco, Michele; Grignaffini, Eugenio; Raposio, Edoardo

    2015-01-01

    Le ulcere cutanee croniche colpiscono circa l’1% della popolazione adulta e il 3.6% della popolazione con più di sessantacinque anni di età. Per quanto riguarda l’impegno finanziario per la terapia delle ulcere cutanee, questo è pari a sette miliardi di euro annui a livello mondiale. Le cellule staminali mesenchimali prelevate da lipoaspirato (ASCs) rappresentano una delle frontiere più promettenti della medicina rigenerativa. Diversi studi hanno, infatti, dimostrato l’efficacia terapeutica di questa popolazione di cellule staminali nel trattamento delle ulcere cutanee croniche. Le ASCs hanno caratteristiche morfologiche e funzionali paragonabili alle cellule staminali del midollo osseo (BMSCs), tuttavia se ne differenziano per la maggiore facilità di prelievo e isolamento, e per il loro più cospicuo numero. È, infatti, sufficiente eseguire una liposuzione tradizionale e in seguito utilizzare metodiche d’isolamento appropriate per ottenere un pellet di ASCs pronte per essere innestate nel fondo e nel margine dell’ulcera cutanea, al fine di promuoverne la guarigione. Diversi sono i protocolli d’isolamento; i più diffusi prevedono complicati e lunghi procedimenti, caratterizzati dal susseguirsi di differenti prodotti sia chimici sia biologici, i quali sono non solo costosi ma anche potenzialmente pericolosi. Il nostro protocollo d’isolamento richiede solo 15’ e prevede che il lipoaspirato sia prima sistemato in uno shaker cellulare e successivamente in una centrifuga così da ottenere le ASCs richieste per la terapia. L’uso delle ASCs si è rivelato una risorsa preziosa per la terapia delle ulcere cutanee croniche, accelerando significativamente il processo di guarigione e la rigenerazione dei tessuti; con protocolli d’isolamento efficaci e semplificati, il loro utilizzo routinario risulta essere facilitato.

  2. Emergency imaging assessment of deep neck space infections.

    Science.gov (United States)

    Maroldi, Roberto; Farina, Davide; Ravanelli, Marco; Lombardi, Davide; Nicolai, Piero

    2012-10-01

    Deep neck space infection may lead to severe and potentially life-threatening complications, such as airway obstruction, mediastinitis, septic embolization, dural sinus thrombosis, and intracranial abscess. The clinical presentation is widely variable, and often early symptoms do not reflect the disease severity. The complication risk depends on the extent and anatomical site: diseases that transgress fascial boundaries and spread along vertically oriented spaces (parapharyngeal, retropharyngeal, and paravertebral space) have a higher risk of complications and require a more aggressive treatment compared with those confined within a nonvertically oriented space (peritonsillar, sublingual, submandibular, parotid, and masticator space). Imaging has 5 crucial roles: (1) confirm the suspected clinical diagnosis, (2) define the precise extent of the disease, (3) identify complications, (4) distinguish between drainable abscesses and cellulitis, and (5) monitor deep neck space infection progression. Ultrasonography is the gold standard to differentiate abscesses from cellulitis, for the diagnosis of lymphadenitis. and to identify internal jugular thrombophlebitis in the infrahyoid neck. However, field-of-view limitation and poor anatomical information confine the use of ultrasonography to the evaluation of superficial lesions and to image-guided aspiration or drainage. Computed tomography (CT) combines fast image acquisition and precise anatomical information without field-of-view limitations. For these reasons, it is the most reliable technique for the evaluation of deep and multicompartment lesions and for the identification of mediastinal and intracranial complications. Contrast agent administration enhances the capability to differentiate fluid collections from cellulitis and allows the detection of vascular complications. Magnetic resonance imaging is more time-consuming than CT, limiting its use to selected indications. It is the technique of choice for assessing

  3. Acute complications of tattooing presenting in the ED.

    Science.gov (United States)

    Kluger, Nicolas

    2012-11-01

    Permanent decorative tattooing involves the introduction of exogenous pigments and/or dyes into the dermis to produce the permanent design. Despite improved hygiene in the tattoo parlors of Western countries, this procedure still carries risk. Various complications may occur right after tattooing, from benign complications such as transient limb edema, palpable lymph nodes, and contact eczema, to more severe ones such as the inoculation of virulent microorganisms into the dermis, potentially life-threatening cellulitis, and necrotizing fasciitis or cutaneous vasculitis. This review focuses specifically on the complications that occur within the first month of tattooing that emergency physicians may have to manage.

  4. Magnetic resonance imaging (MRI) in the diagnosis of head and neck disease.

    Science.gov (United States)

    Supsupin, Emilio P; Demian, Nagi M

    2014-05-01

    Magnetic resonance imaging (MRI) is the modality of choice to identify intracranial or perineural spread from a head and neck primary tumor. Perineural spread is a form of metastatic disease in which primary tumors spread along neural pathways. Orbital cellulitis is a sight-threatening, and potentially life-threatening condition. Urgent imaging is performed to assess the anatomic extent of disease, including postseptal, cavernous sinus, and intracranial involvement, and identify orbital abscesses that require exploration and drainage. MRI is useful in the evaluation of the brachial plexus.

  5. Operational accidents in EL 2 and EL 3 between 1.1. 1957 and 1.7.1959 (1960); Incidents de fonctionnements a EL 2 et EL 3 entre le 1.1. 1957 et le 1.7. 1959 (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Balligand, P. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The two most important accidents, costing 50 days out of operation for EL3 and 43 days for EL2, were due to the melting of a fuel rod through a cooling defect in a cell; the behaviour of the fuel could not otherwise be considered responsible. (author) [French] Les deux incidents les plus importants qui ont coute 50 jours d'arret pour EL3 et 43 jours pour EL2, ont ete dus a la fusion d'une barre de combustible par defaut de refroidissement dans une cellule, sans que la bonne tenue du combustible puisse, par ailleurs, etre mise en cause. (auteur)

  6. Bisphosphonate-related osteonecrosis of the jaw complicated by Ludwig's angina.

    Science.gov (United States)

    Yang, Rong-Hsin; Shen, Shu-Huei; Li, Wing-Yin; Chu, Yum-Kung

    2015-01-01

    Ludwig's angina is a life-threatening cellulitis that involves the submandibular and sublingual spaces. It often occurs after an infection of the roots of the teeth. However, modern dental care and use of antibiotics for oral infections have made Ludwig's angina rare. We present here a cancer patient exhibiting the sequential features of bisphosphonate related osteonecrosis of the jaw on bone scan complicating with Ludwig's angina. This report highlights the need for medical practitioners to be alert to these rare combinations in the compromised patient after bisphosphonate therapy. To the best of our knowledge, no case of Ludwig's angina secondary to osteonecrosis of the jaw has been reported.

  7. L'atteinte osseuse dans le sarcome de Kaposi classique et agressif: à propos d'un cas

    Science.gov (United States)

    Sbiyaa, Mouhcine; El Alaoui, Adil; El Bardai, Mohammed; Mezzani, Amine; Lahrach, Kamal; Marzouki, Amine; Boutayeb, Fawzi

    2016-01-01

    Le sarcome de Kaposi classique est une tumeur rare multifocale d'origine des cellules endothéliales vasculaires à caractère évolutif progressif et peu maligne. L'atteinte viscérale dans le sarcome de kaposi est parfois observée chez les patients VIH positif par contre la dissémination tumorale dans les ganglions lymphatiques viscérales dans le SK classique reste très rare. On rapporte un cas rare de sarcome de kaposi classique agressif de la main avec une évolution rapide et destructive. PMID:27347285

  8. Management of Large Erupting Complex Odontoma in Maxilla

    Directory of Open Access Journals (Sweden)

    Colm Murphy

    2014-01-01

    Full Text Available We present the unusual case of a large complex odontoma erupting in the maxilla. Odontomas are benign developmental tumours of odontogenic origin. They are characterized by slow growth and nonaggressive behaviour. Complex odontomas, which erupt, are rare. They are usually asymptomatic and are identified on routine radiograph but may present with erosion into the oral cavity with subsequent cellulitis and facial asymmetry. This present paper describes the presentation and management of an erupting complex odontoma, occupying the maxillary sinus with extension to the infraorbital rim. We also discuss various surgical approaches used to access this anatomic area.

  9. Aircraft Corrosion

    Science.gov (United States)

    1981-08-01

    qualitd fail-safe de is structure ont Etd vdrifides au cours de l’essai de is cellule de fatigue de cat avion : en effet , une crique, initide sur is...pout subir I& structure de 1’avion hormis lea effets micaniques bien que ces derniers interfirent avec lea agents physico-chlmlques. * G~~ali~e. La...iprouvettes (cylindriques ou iquorres) ont iti solliclties en flexion par llinterrnidiaire d’un bras do levier . Le schima do I& planche 7 donne le

  10. Contribution à l’étudié de l’effet des extraits phénoliques des plantes et microorganismes antagonistes sur la croissance de deux champignons :Verticilliumdahliae et Fusariumoxysporum.

    OpenAIRE

    Messaoudi, Asmaa

    2014-01-01

    50 Résumé Les plantes font partie du vivant, elles respirent, se nourrissent, naissent et meurent. Les plantes sont, comme l'humain, composées de cellules. Les vecteurs de maladie, et la maladie elle-même ont les mêmes origines chez les plantes, que chez tout les autres être vivant: Les virus, les bactéries, les champignons, attaques de nuisible. Vu le grand nombre de maladie possible chez les plantes, nous n'allons décrire que les plus connue ; Les maladies cryptogamique...

  11. Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.

    Science.gov (United States)

    Bolognia, J L

    1991-01-01

    Pentamidine is one of two agents currently used to treat infections with Pneumocystis carinii. The intramuscular route of administration is associated with cutaneous side effects such as dermal necrosis, sterile abscesses and ulcer formation at the injection site, while urticaria may develop near the site of intravenous drug infusion. This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm. The area healed slowly over 7 weeks, but there was a residual loss of cutaneous sensation. In a review of the literature no report of a similar case was found.

  12. Managment of orbital complications of sinusitis

    Directory of Open Access Journals (Sweden)

    Fazil Emre Ozkurt

    2014-10-01

    Full Text Available Purpose: We reported on the clinical approaches of ophthalmology and otorhinolaryngology departments in the treatment of the orbital complications of sinusitis. We also included an in-depth literature review. Methods: We retrospectively reviewed the medical files of 51 patients from January 2008 to January 2014. The records were evaluated for age, gender, type of orbital complications, symptoms, predisposing factors, imaging studies, medical and surgical management, culture results, and follow-up information. SPSS version 15.0 software (Statistical Analysis, The Statistical Package for Social Sciences Inc, Chicago, IL was used for the statistical analysis. Results: Fifty-one patients met the criteria, with available medical records, for the study (29 male, 22 female. Thirty-two (62.7% were diagnosed with preseptal cellulitis and 19 (37.3% with postseptal cellulitis. After a detailed evaluation, 15 were diagnosed with a subperiosteal abscess (SPA, and 4 were diagnosed with orbital cellulitis. The age and gender was similar for the two groups. Five patients with medial SPA were treated with endoscopic sinus surgery, one patient with inferior SPA was treated with external surgery, and six patients with other localizations were treated with a combination of endoscopic sinus surgery and external surgery. All patients presented with periorbital erythema and edema. The length of hospitalization and duration of symptoms were similar in both groups. Visual acuity was between 1/10 to 10/10 (mean 7/10 and statistically significant for preseptal and postseptal cellulitis groups (p<0.001. All patients received intravenous antibiotics upon the first day of admission. Conclusion: Orbital complications of acute sinusitis required intensive follow-up and a multidisciplinary approach. A contrast-enhanced paranasal sinus computerized tomography (CT scan can detect the extent of the infection. An initial trial of intravenosus (IV antibiotics may be appropriate when

  13. [Orbital complications of sinusitis].

    Science.gov (United States)

    Šuchaň, M; Horňák, M; Kaliarik, L; Krempaská, S; Koštialová, T; Kovaľ, J

    2014-12-01

    Orbital complications categorised by Chandler are emergency. They need early diagnosis and agresive treatment. Stage and origin of orbital complications are identified by rhinoendoscopy, ophtalmologic examination and CT of orbite and paranasal sinuses. Periorbital cellulitis and early stage of orbital cellulitis can be treated conservatively with i. v. antibiotics. Monitoring of laboratory parameters and ophtalmologic symptoms is mandatory. Lack of improvement or worsening of symptoms within 24-48 hours and advanced stages of orbital complications are indicated for surgery. The purpose of the study is to evaluate epidemiology, clinical features and management of sinogenic orbital complications. Retrospective data of 8 patients with suspicion of orbital complication admited to hospital from 2008 to 2013 were evaluated. Patients were analyzed in terms of gender, age, CT findings, microbiology, clinical features, stage and treatment. Male and female were afected in rate 1,66:1. Most of patients were young adult in 3rd. and 4th. decade of life (62,5 %). Acute and chronic sinusitis were cause of orbital complication in the same rate. The most common origin of orbital complication was ethmoiditis (62,5 %), than maxillary (25 %) and frontal (12,5 %) sinusitis. Polysinusitis with affection of ethmoidal, maxillary and frontal sinuses (75 %) was usual CT finding. Staphylococcus epidermidis and Staphylococcus aureus were etiological agens in half of cases. Periorbital oedema (100 %), proptosis, chemosis (50 %), diplopia and glaucoma (12,5 %) were observed. Based on examinations, diagnosis of periorbital oedema/preseptal cellulitis was made in 3 (37,5 %), orbital cellulitis in 3 (37,5 %) and subperiosteal abscess in 2 cases (25 %). All patients underwent combined therapy - i. v. antibiotics and surgery within 24 hours. Eradication of disease from ostiomeatal complex (OMC), drainage of affected sinuses and drainage of subperiosteal abscess were done via fuctional endonasal

  14. Chemotherapy-induced Neutropenia

    Directory of Open Access Journals (Sweden)

    A. Catherine Casey

    1995-01-01

    Full Text Available Background:Pasteurella multocida is a commensal organism found in the saliva and oropharynx of domestic animals. It causes a variety of human infections ranging from cellulitis to bacteremia and sepsis. The severity of infection is somewhat related to the immunocompetency of the infected host. An immunocompromised host is more likely to suffer a disseminated infection as a result of contact with this organism than an immunocompetent host. This case report and review of the literature are presented to further evaluate the types of infections caused by this organism in oncology patients.

  15. Three eyelid localized cutaneous anthrax cases.

    Science.gov (United States)

    Esmer, Oktay; Karadag, Remzi; Bilgili, Serap Gunes; Gultepe, Bilge; Bayramlar, Huseyin; Karadag, Ayse Serap

    2014-12-01

    Anthrax is primarily seen in the developing countries, but it can be a worldwide medical concern due to bioterrorism threats. Palpebral anthrax is a rare form of cutaneous anthrax. Untreated cutaneous anthrax can be lethal. Patients with palpebral anthrax can develop complications including cicatrisation and ectropion. Thus, anthrax should be considered in differential diagnosis for patients presenting with preseptal cellulitis in high-risk regions. Herein, we report three anthrax cases (with different age) involving eyelids that were cured without any complications due to early diagnosis and treatment.

  16. Validation Report for Joint Medical Planning Tool (JMPT) Version 7.5.6 Medical Planning Tool

    Science.gov (United States)

    2013-09-19

    815.0 Closed fracture of metacarpal bones Surgical 959.09 Other and unspecified injury to face and neck Surgical 918.1 Superficial injury cornea ...injury to head Surgical 831.1 Dislocation of shoulder, open Surgical 553.1 Umbilical hernia Surgical 918.1 Superficial injury cornea Surgical...surgical 847.3 Sprain of sacrum Non-surgical 724.2 Lumbago Non-surgical 724.02 Spinal stenosis of lumbar region Non-surgical 681 Cellulitis and abscess

  17. Hereditary angioedema type 2 presented as an orbital complication of acute rhinosinusitis.

    Science.gov (United States)

    Somuk, Battal Tahsin; Göktas, Göksel; Özer, Samet; Sapmaz, Emrah; Bas, Yalcın

    2016-03-01

    Hereditary angioedema is an autosomal dominant and life-threatening disorder characterized by recurrent episodes of non-pitting edema affecting the skin, respiratory system and digestive tracts and caused by a congenital deficiency or function defect of the C1 esterase inhibitor. Preseptal cellulitis is defined as an infection of the tissues of the anterior orbital septum. It is generally caused by complications from an upper respiratory tract infection, dacryocystitis, dermal infection, and, rarely, sinusitis. The disease presents with orbital pain, edema on the eyelids, erythema, and fever. In this case, a child with hereditary angioedema type 2 who presented as mimicking a complication of acute sinusitis is discussed.

  18. Bilateral parotid enlargement following snake bite:A rare sign

    Institute of Scientific and Technical Information of China (English)

    Madi Deepak; Achappa Basavaprabhu; John T Ramapuram; Chowta Nithyananda; Soundarya Mahalingam

    2013-01-01

    Snakebite is a common medical emergency in India. Unusual complications may occur after viper bite. Bilateral parotid enlargement after viper bite is a rare entity. An 18-year old gentleman presented to our hospital with history of viper bite. On examination he had cellulitis of right lower limb. He developed swelling of both the parotid glands 12 h after admission. He developed coagulopathy, acute renal failure and died within 48 h of hospital admission. Development of parotid swelling after snake bite is associated with poor prognosis. This case is found worth reporting as it is an unusual complication having prognostic value.

  19. Action palliative par le convertisseur statique en cas de défaillance d'un générateur PAC modulaire de puissance

    OpenAIRE

    Frappé, Emmanuel; De Bernardinis, Alexandre; Bethoux, Olivier; Marchand, Claude; Coquery, Gérard

    2010-01-01

    International audience; La montée en puissance des piles à combustible se heurte à des difficultés d'ordre mécanique et fluidique, limitant l'assemblage en série de cellules unitaires pour les piles de forte puissance. Aussi, à l'heure actuelle, est-il plus aisé de concevoir des générateurs pile à combustible associant plusieurs piles unitaires, dits " multi-stack ". L'approche multi-stack permet en outre de gérer d'éventuelles défaillances pouvant intervenir sur l'une des piles en fonctionne...

  20. Radionuclide imaging in skeletal inflammatory and ischemic disease in children. [/sup 99m/Tc tracer technique

    Energy Technology Data Exchange (ETDEWEB)

    Majd, M.; Frankel, R.S.

    1976-04-01

    Sixty-five children were evaluated for presence of skeletal inflammatory and ischemic disease with bone scans and roentgenograms. Several characteristic scintigraphic patterns were observed. Bone scans were significantly more sensitive than roentgenograms in early diagnosis of osteomyelitis and its differentiation from cellulitis, septic arthritis, and bone infarction. The child with possible inflammatory bone disease now is benefited by this important refinement in diagnosis. Faced with the difficult dilemma of choosing appropriate therapy in these frustratingly similar problems, the physician can integrate the clinical findings with nuclear imaging to arrive at early appropriate diagnosis and management.

  1. Case series on tropical diabetic hand syndrome.

    Science.gov (United States)

    Ezeani, I U; Edo, A E

    2014-01-01

    Tropical diabetic hand syndrome is a term used to describe diabetes complication of the hand affecting people in the tropics. It consists of localized cellulitis with variable swelling and ulceration of the hands, progressive, fulminant hand sepsis and gangrene in extreme cases. This syndrome is not well-recognized and is therefore less frequently reported. The authors describe three different female patients who were known diabetics of varying duration presenting with this syndrome at our tertiary health center and who were successfully managed by both the surgical and medical units. The need for early diagnosis and aggressive management is emphasized.

  2. Operadic Definition of Non-Stricts Cells

    OpenAIRE

    Kachour, Camell

    2010-01-01

    In [K. Kachour. D\\'efinition alg\\'ebrique des cellules non-strictes. Cahiers de Topologie et de G\\'eom\\'etrie Diff\\'erentielle Cat\\'egorique, 1:1-68, 2008] we pursue Penon's work in higher dimensional categories by defining non-strict infinity-functors, non-strict natural infinity-transformations, and so on, all that with Penon's frameworks i.e with the "\\'etirements cat\\'egoriques", where we have used an extension of this object, namely the "n-\\'etirements cat\\'egoriques" (n belong in N). In...

  3. Nuclear warfare

    CERN Multimedia

    Broda

    1981-01-01

    Le Prof.Broda a étudié à Vienne et Berlin et a travaillé pendant la dernière guerre mondiale en Grande Bretagne pour le conseil de la recherche médicale, notamment sur la chimie de la vision. Il est maintenant Prof. de la chimie, physique et radiochimie à l'Université de Vienne, où il concentre ses travaux sur les méchanisme de transport d'énergie à travers les cellules de membranes.

  4. Methicillin-resistant Staphylococcus aureus laryngitis.

    Science.gov (United States)

    Liakos, Tracey; Kaye, Keith; Rubin, Adam D

    2010-09-01

    Infections due to methicillin-resistant Staphylococcus aureus (MRSA) have become more prevalent, in part because of the emergence and spread of community-acquired MRSA. This trend is particularly concerning because of the significant rates of morbidity and mortality associated with MRSA infections, and because MRSA strains are often resistant to many classes of antibiotics. Reports of infections of the head and neck, including wound infections, cellulitis, sinusitis, otitis media, and otitis externa, are well documented. However, to our knowledge, there have been no reports of bacterial laryngitis due to MRSA. We report the first published case of bacterial laryngitis caused by MRSA.

  5. Necrotizing Fasciitis of the Nose Complicated with Cavernous Sinus Thrombosis

    Directory of Open Access Journals (Sweden)

    D. Swaminath

    2014-01-01

    Full Text Available Necrotizing fasciitis is a rapidly progressive life threatening bacterial infection of the skin, the subcutaneous tissue, and the fascia. We present a case of necrotizing fasciitis involving the nose complicated by cavernous sinus thrombosis. Few cases of septic cavernous sinus thrombosis have been reported to be caused by cellulitis of the face but necrotizing fasciitis of the nose is rare. It is very important to recognize the early signs of cavernous thrombosis. Treatment for septic cavernous sinus thrombosis is controversial but early use of empirical antibiotics is imperative.

  6. Medicolegal aspects of necrotizing fasciitis of the neck.

    Science.gov (United States)

    Sperry, K; McFeeley, P J

    1987-01-01

    Necrotizing fasciitis of the neck (NFN) is a relatively rare, fulminating infectious process of the cervicofacial tissues which may cause sudden and unexpected death. Although often the result of a dental infection, injuries of the soft tissues of the neck may also initiate rampant cellulitis, and recognition of the underlying etiology of such cases is necessary to determine properly the manner of death. Five cases of NFN are presented with a review of the causative factors and usual bacteriology, and specific factors of medicolegal interest are addressed.

  7. Oméga 3 et neurotransmission cérébrale

    OpenAIRE

    Vancassel Sylvie

    2004-01-01

    Les acides gras polyinsaturés (AGPI) sont des constituants structuraux fondamentaux du système nerveux central (SNC) dont la teneur conditionne le fonctionnement des cellules neuronales. Ils sont des acteurs de la communication intercellulaire, notamment à travers les processus de neurotransmission. De nombreuses études ont montré chez l’animal que le déficit des membranes cérébrales en oméga 3, et plus particulièrement en acide docosahexaénoïque (22 : 6ω-3 ou DHA) induit par une carence alim...

  8. Improved early diagnosis of acute inflammatory skeletal-articular diseases in children: A two-radiopharmaceutical approach

    Energy Technology Data Exchange (ETDEWEB)

    Handmaker, H.; Giammona, S.T.

    1984-05-01

    The febrile child with a painful bone or joint still presents a difficult pediatric diagnostic problem. Acute hematogenous osteomyelitis, septic arthritis, and cellulitis are the most common causes of this symptom. Thirty-seven patients with these disorders were studied. Because findings from technetium-99m phosphate bone scans and roentgenograms are often normal in patients in the early stages of acute hematogenous osteomyelitis, children suspected of having this disorder were tested using gallium-67 citrate scans in addition to the other diagnostic procedures. The increased diagnostic accuracy of this approach over that of bone scan and roentgenogram studies alone was observed in the children with fever and bone or joint pain.

  9. System Identification for Integrated Aircraft Development and Flight Testing (l’Identification des systemes pour le developpement integre des aeronefs et les essais en vol)

    Science.gov (United States)

    1999-03-01

    essais environ. Un outil d’optimisation param6trique IDLATNL a donc 6t6 naturellement d~velopp6 pour aider 5. IDLATNL Fing~nieur A r~soudre ce probl~me...support h de nombreux essais en vol sous contrat des Services Officiel Franqais (SPA6). 3. CAPTEURS Ce dispositif experimental a W utilis6 dans le...proviennent d’une travaillant dans le domaine fr~quentiel, fournit une centrale h inertic et de capteurs sp~cifiques cellule en cc qui estimation des

  10. Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series

    Directory of Open Access Journals (Sweden)

    Marjan Islam

    2016-01-01

    Full Text Available Infections from Streptococcus dysgalactiae ssp. equisimilis (SDSE can cause a wide variety of infections, ranging from mild cellulitis to invasive disease, such as endocarditis and streptococcal toxic shock-like syndrome (TSLS. Despite prompt and appropriate antibiotics, mortality rates associated with shock have remained exceedingly high, prompting the need for adjunctive therapy. IVIG has been proposed as a possible adjunct, given its ability to neutralize a wide variety of superantigens and modulate a dysregulated inflammatory response. We present the first reported cases of successful IVIG therapy for reversing shock in the treatment of SDSE TSLS.

  11. Pyoderma gangrenosum induced by episiotomy.

    Science.gov (United States)

    Alani, Angela; Sadlier, Muriel; Ramsay, Bart; Ahmad, Kashif

    2016-01-19

    We present a patient who developed genital ulceration within hours following episiotomy procedure during a normal vaginal delivery. This was initially treated by the gynaecology and medical team as cellulitis with no improvement. A diagnosis of pyoderma gangrenosum (PG) was made by the dermatology team 12 days later. On further investigation, she was found to be hepatitis C positive. We report this case to highlight the phenomenon of pathergy and frequent misdiagnosis of PG by other medical teams. When a postsurgical wound is not healing despite relevant systemic treatment, the clinician should suspect PG as an early diagnosis and treatment is crucial.

  12. Acquired lymphangiectasis following surgery and radiotherapy of breast cancer

    Directory of Open Access Journals (Sweden)

    Angoori Gnaneshwar Rao

    2015-01-01

    Full Text Available Acquired lymphangiectasia (AL is a significant and rare complication of surgery and radiotherapy. We report lymphangiectasia in a 40-year-old woman who had undergone radical mastectomy and radiotherapy. After 4 years of combined therapy, she developed multiple vesicles and bullae. Skin biopsy confirmed the diagnosis of lymphangiectasia. The case is unique as it is not associated with lymphedema, which is a usual accompaniment of lymphangiectasia following surgery and radiotherapy. AL is usually asymptomatic, but trauma may cause recurrent cellulitis. Treatment modalities include electrodessication, surgical excision, sclerotherapy and carbon dioxide laser ablation.

  13. Rundorme - små forsøgsdyr med store muligheder

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen; Wang, Tobias

    2015-01-01

    Rundormen Caenorhabditis elegans er det seneste halve århundrede blevet et vigtigt forsøgsdyr, som har lært os meget om den genetiske styring fra befrugtet ægcelle til voksent individ. Den har lært os om programmeret celledød og om en vigtig cellulær mekanisme, der beskytter cellerne mod...... virusangreb. I dag bruges Caenorhabditis elegans også som dyremodel for en række specifikke sygdomme såsom Alzheimers sygdom....

  14. Necrotizing (malignant otitis externa: An unusual localization of mucormycosis

    Directory of Open Access Journals (Sweden)

    Tuzcu A

    2006-01-01

    Full Text Available Malignant otitis externa (MOE is a severe infection of external auditory canal and skull base. A 17-year-old diabetic girl was admitted with diabetic ketoacidosis. Cellulitis of her right ear occurred on the second day of hospitalization and a black necrotic scar in the same region appeared on the next day. The lesion rapidly invaded to right side of neck and surrounding tissue of the patient. Therefore, antimycotic therapy was started. Unfortunately the patient died on seventh day of hospitalization because of probably extensive fungal invasion. Physicians should suspect MOE connected to mucormycosis especially in patients with cutaneous lesions of ear unresponsive to antibiotic therapy.

  15. MR imaging findings of orbitofacial infarction secondary to rhinoorbital mucormycosis : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Jong Kwan; Lee, Jae Hee; Jeon, Eun Ju; Kim, Kyong Mee; Kim Ki Jun; Lee, Sung Yong [Our Lady of Mercy Hospital, the Catholic University of Korea, Seoul (Korea, Republic of); Choi, Kyu H. [Kangnam' s St. Mary' s Hospital, Seoul (Korea, Republic of)

    2000-02-01

    Rhino-orbital mucormycosis is the most frequently fatal fungal infection commonly occurring in patients with poorly controlled diabetes mellitus and those who are immunocompromised, and requires prompt treatment. We describe a case of rhino-orbital mucormycosis with orbital cellulitis and paranasal sinusitis, as seen on initial MR images, which on follow-up images had evolved to orbitofacial infarction. MR imaging was useful for the demonstration of orbitofacial infarction, seen as areas of lack of enhancement and thus suggesting vascular involvement by mucor hyphae. (author)

  16. Mild forms of toxic shock syndrome toxin-1-mediated exanthematous disease related to Staphylococcus aureus infection.

    Science.gov (United States)

    Moriguchi, Naohiko; Kano, Tomowa; Yoshimatsu, Yutaka; Yanagida, Hidehiko

    2016-08-01

    The present report describes three patients with toxic shock syndrome toxin (TSST)-1-associated exanthematous disease. In all patients, fever and systemic erythema without hemodynamic disturbance occurred following cellulitis of the lower limbs. At the site of infection, TSST-1 producing Methicillin-susceptible Staphylococcus aureus was detected. They defervesced and erythema resolved in response to administration of an antimicrobial drug, thereby avoiding severe illness. These patients did not meet the criteria for a clinical diagnosis of toxic shock syndrome. Measurement of T-cell receptor Vβ2-positive T cells in the peripheral blood early after onset of symptoms was useful for diagnosis.

  17. Table des illustrations

    OpenAIRE

    2016-01-01

    Figure 1 - Kakopétria, Saint-Nicolas-du-Toit, Alexis l’Homme de Dieu et Jean Kalybitès 339 Figure 2 - Kastoria, Panagia Mavriotissa, Alexis l’Homme de Dieu 340 Figure 3 – Peć, Église de la Vierge Hodigitria, Alexis l’Homme de Dieu 340 Figure 4 - Göreme, Tokali kilise II (Nouvelle Église), Alypios 341 Figure 5 - Venise, Saint-Marc, Alypios 341 Figure 6 - Paphos, Saint-Néophyte, naos, Euthyme et Amoûn le Nitriote 342 Figure 7 - Paphos, Saint-Néophyte, cellule, André Salos 342 Figure 8 - Lagoudé...

  18. A rare glimpse into the morbid world of necrotising fasciitis: Flesh-eating bacteria Vibrio vulnificus

    Directory of Open Access Journals (Sweden)

    M Madiyal

    2016-01-01

    Full Text Available Necrotising fasciitis is one of the fatal skin and soft tissue infections. Vibrio vulnificus is a rare cause of necrotising fasciitis; however, the disease is one of the major manifestations of the bacteria. Here, we report one such case in a middle-aged male patient. He presented with the signs of bilateral lower limb cellulitis and altered sensorium. V. vulnificus was isolated from blood culture and also from debrided tissue. Though the organism is well characterised, it is a rare causative agent of necrotising fasciitis. This case is a re-emphasis on active look out for this bacterium in patients presenting with necrotizsing fasciitis.

  19. Human Dirofilaria repens Infection in Romania: A Case Report

    Directory of Open Access Journals (Sweden)

    Ioana Popescu

    2012-01-01

    Full Text Available Human dirofilariasis is a zoonotic infectious disease caused by the filarial nematodes of dogs Dirofilaria repens and Dirofilaria immitis. Depending on the species involved, human infections usually manifest as one cutaneous or visceral larva migrans that forms a painless nodule in the later course of disease. Dirofilariae are endemic in the Mediterranean, particularly in Italy. They are considered as emerging pathogens currently increasing their geographical range. We present one of the few known cases of human dirofilariasis caused by D. repens in Romania. The patient developed unusual and severe clinical manifestations that mimicked pathological conditions like cellulitis or deep venous thrombosis.

  20. Post-septal orbital complications of acute bacterial rhinosinusitis: Endoscopic anatomical considerations

    Directory of Open Access Journals (Sweden)

    Ahmed A. Ibrahim

    2015-11-01

    The study was carried out on 240 patients suffering from acute rhino-sinusitis with 90 patients suffering from orbital post-septal complicating acute rhino-sinusitis. Eighty-five cases underwent orbital decompression, except 5 cases with orbital cellulitis; they were improved on medical treatment. Visual monitoring by the ophthalmological team on regular basis was performed, until clinical and radiological improvement of the condition. This study proves that there may be a relationship between anatomic variation and orbital infections complicating acute sinusitis or acute on top of chronic sinusitis.

  1. THE REHABILITATION MANAGEMENT OF LYMPHEDEMA

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    OJOGA Florina

    2015-05-01

    Full Text Available Lymphedema is an important pathology for rehabilitation medecine, especially for the patients who underwent a mastectomy for breast cancer. His frequency is higher when mastectomy is combined with lymph node disection and irradiation of the lymph nodes. Symptoms include heaviness, numbness, pain, stiffness and weakness in the affected limb. Complications of lymphedema include infections such as cellulitis, erysipelas and lymphangitis. Treatment must be instituted as soon as possible and preventive measures are essential. The rehabilitation treatment consists of skin care measures, manual lymphatic massage, elastic compression of the affected limb and kinetotherapy.

  2. 儿童重症眼眶蜂窝织炎病因分析%Etiology of children's severe orbital cellulites

    Institute of Scientific and Technical Information of China (English)

    钟晖; 陈凌燕; 方旺; 张莉; 王莉; 肖诗艺

    2013-01-01

    Objective To discuss the etiology and risk factors of children's severe orbital cellulitis.Methods Medical records of 53 cases of severe orbital cellulitis that were admitted by Shenzhen Children's Hospital from January 2010 to June 2012 were retrospectively reviewed.Results Severe orbital cellulitis appeared to peak in May and November in children.White blood cell count and C-reactive protein were 19.2 ± 3.9 × 109/L and 54.2 ± 6.1 mg/L respectively.Staphylococcus aureus is still the major pathogens found in patients'blood,abscess or secretions.While the most important risk factors are sinusitis (52.8%) and upper respiratory infection (26.4%).Conclusion Treatment targeted on etiologies and risk factors is the most effective way to manage severe orbital cel-lulitis in children.%目的 探讨儿童重症眶蜂窝组织炎的致病因素.方法 对深圳市儿童医院2008年1月至2012年6月住院的53例(53只眼)儿童重症眼眶蜂窝织炎病例资料进行回顾性研究.结果 儿童重症眼眶蜂窝织炎好发于5月及11月;外周血白细胞计数及血清C反应蛋白平均值分别为(19.2±3.9)×109/L和(54.2±6.1) mg/L;血培养、脓液或分泌物均显示金黄色葡萄球菌是最常见致病菌;鼻窦炎(52.8%)和上呼吸道感染(26.4%)是儿童重症眼眶蜂窝织炎的最主要致病原因.结论 了解儿童重症眼眶蜂窝织炎的常见病因,针对病因治疗可以有效的提高该病的疗效及预后.

  3. Computed tomographic detection of sinusitis responsible for intracranial and extracranial infections

    Energy Technology Data Exchange (ETDEWEB)

    Carter, B.L.; Bankoff, M.S.; Fisk, J.D.

    1983-06-01

    Computed tomography (CT) is now used extensively for the evaluation of orbital, facial, and intracranial infections. Nine patients are presented to illustrate the importance of detecting underlying and unsuspected sinusitis. Prompt treatment of the sinusitis is essential to minimize the morbidity and mortality associated with complications such as brain abscess, meningitis, orbital cellulitis, and osteomyelitis. A review of the literature documents the persistence of these complications despite the widespread use of antibiotic therapy. Recognition of the underlying sinusitis is now possible with CT if the region of the sinuses is included and bone-window settings are used during the examination of patients with orbital and intracranial infection.

  4. LUDWIG’S ANGINA AND ANAESTHETIC DIFFICULTIES: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Sarda Devi

    2015-04-01

    Full Text Available Patients with deep neck infections present challenging airways for an anesthesiologist . Ludwig’s angina is potentially lethal, rapidly spreading cellulitis involving the floor of the mouth and neck. Without aggressive management it often results in life th reatening upper airway obstruction. Securing the airway remains the top priority in treatment of Ludwig’s angina. Although awake fibreoptic intubation remains the ideal method for securing the airway, but it is not available in every set up, so all feasibl e options of securing the airway should be prepared. We present a case successfully managed at our hospital with a brief review of airway management options.

  5. Staphylococcus lugdunensis gluteal abscess in a patient with end stage renal disease on hemodialysis

    Directory of Open Access Journals (Sweden)

    Mansoor Mehmood

    2015-01-01

    Full Text Available A 57-year-old end stage renal disease patient on hemodialysis (HD presented with sepsis secondary to right buttock abscess and overlying cellulitis. She was started on broad-spectrum antibiotic therapy and underwent incision and drainage with marked improvement. Her cultures grew methicillin-resistant Staphylococcus lugdunensis. This bacterium is more virulent than other coagulase negative staphylococci and has been implicated in causing a variety of serious infections but it has been underreported as a cause of skin infections in HD patients and possible other patient populations.

  6. Ambulatory Visits Among Members of the Active Component, U.S. Armed Forces, 2011

    Science.gov (United States)

    2012-04-01

    gastroenteritis/colitis 56,345 24.1 Viral and chlamydial infection 36,345 19.7 Diseases of esophagus 34,466 14.7 Dermatophytosis 28,381 15.4...Gastrointestinal hemorrhage 15,252 6.5 Streptococcal sore throat and scarlet fever 11,317 6.1 Inguinal hernia 14,089 6.0 Intestinal infections due to other...immunity (240 - 279) 119,054 Skin and subcutaneous tissue (680 - 709) 315,578 Disorders of lipoid metabolism 35,989 30.2 Other cellulitis and abscess 56,135

  7. Geocontainers in road building and hydraulic engineering construction

    OpenAIRE

    2011-01-01

    Geocontainers are structural loops made of high-strength geotextile. In the course of construction they are filled by ground or inert material on-site. The geomatrix is the next step in the development of geocontainers. It is the cellular structure made of geotextile, the cellules are connected by lacing or by thermal welding.The aim of the article is to acquaint the reader with this type of geomaterials, possibilities of its use in different areas of construction.The technology of using geoc...

  8. Squamous cell carcinoma and pilonidal cyst disease.

    Science.gov (United States)

    Esposito, Francesco; Lauro, Mario; Tirone, Lucio Pasquale; Festa, Rosa Maria; Peluso, Gaia; Mazzoni, Giada; Scognamiglio, Marco; Grimaldi, Simona; Fresini, Antonio

    2015-02-20

    Il carcinoma a cellule squamose insorgente su malattia del seno pilonidale è una patologia abbastanza rara che sopraggiunge in presenza di malattia con decorso decennale. È caratterizzato da una crescita lenta ma da un’elevata invasività locale. Gli autori riportano il caso di un paziente di 63 anni con storia pluridecennale di malattia del seno pilonidale con ascessualizzazioni ricorrenti trattato chirurgicamente con resezione ampia e ricostruzione mediante uso di lembi. A distanza di 30 mesi non sono state osservate complicanze o recidive locali.

  9. Annual progress report, July 1, 1983-June 30, 1984

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    Research in the Laboratory of Biomolecular and Celluler Sciences deals with proliferation, gene expression and differentiation in normal cells and in cells exposed to pollutants, carcinogens or tumor promoters. The research program of the Laboratory of Environmental Biology presents an integrated approach to studies of the functional interactions of the physical and biotic components of arid land ecosystems. Nuclear Medicine research has focussed on development of positron emission tomography, preparation of short-lived isotopes of oxygen, nitrogen, carbon and fluorine, use of these isotopes to label physiological substrates, tracer studies of cerebral biochemistry and physiology, measurement of regional myocardial fatty acid metabolism and blood flow. (AER)

  10. Submasseteric Infection: A Rare, Deep Space Cheek Infection Causing Trismus.

    Science.gov (United States)

    Schwartz, Richard H; Bahadori, Robert S; Willis, Andrea

    2015-11-01

    Submasseteric space infections are rare at any age but particularly so in primary school children. The origin of the infection is usually odontogenic, from pericoronitis in a third molar. Submasseteric inflammation is a deep facial space inflammation, often progressing to mature abscess, and usually misdiagnosed as staphylococcal or streptococcal lymphadenitis or pyogenic parotitis. The hallmark of a masticatory space infection is trismus. The cardinal signs of this infection include a firm mass in the body of the masseter muscle with overlying cellulitis with trismus.

  11. Hémangiome fusiforme: une localisation inhabituelle

    Science.gov (United States)

    Nasreddine, Fatima Zahra; Baghad, Bouchra; Chiheb, Soumiya

    2016-01-01

    L'hémangiome à cellules fusiformes été décrit par Weiss et Enzinger en 1986 et anciennement nommé hémangioendothéliome à cellules fusiformes. Depuis l'avènement des études immunohistochimique il n'est plus considéré en tant qu'angiosarcome de bas grade. C'est une tumeur bénigne vasculaire. Il touche presque exclusivement le derme des extrémités distales. Nous rapportons le premier cas avec localisation au niveau de l'omoplate, du sein, des cuisses et de la mandibule. Selon la littérature, seulement 9 cas localisés au niveau de la tête et le cou ont été rapportés. Nous rapportons un nouveau cas de cette entité rare et mal connue qui peut prêter confusion avec les tumeurs malignes. Notre patient avait une localisation au niveau de l'omoplate, du sein, des cuisses et de la mandibule. Une biopsie-exérèse était réalisée. L’évolution a été favorable avec un recul de 6 mois, sans rechute. PMID:27642429

  12. Sonographic Diagnosis in a Rare Aetiology of Neonatal Scrotal Swellings: A Case Report of Congenital Nephrotic Syndrome

    Science.gov (United States)

    Grover, Shabnam Bhandari; Kumar, Nishith; Grover, Hemal; Taneja, Dinesh Kumar; Katyan, Amit

    2016-01-01

    Summary Background Common etiologies of scrotal swelling in neonates include hydrocoele, inguinal hernia and testicular torsion; less common is epididymo-orchitis. Congenital nephrotic syndrome (CNS), a rare entity, is known to present as progressive renal failure and its leading presentation with scrotal involvement has not been reported. Material/Methods We report a rare case of CNS with primary clinical presentation as scrotal cellulitis and epididymo-orchitis. In this neonate, scrotal and abdominal ultrasound examination was performed and the laboratory data were obtained. Results Sonography revealed bilaterally enlarged echogenic kidneys, testis and epididymis with echogenic peritoneal fluid tracking into both scrotal sacs. Laboratory data revealed proteinuria and severe depletion of serum IgG. Culture of the peritoneal fluid showed gram-negative organisms. A final diagnosis of CNS, complicated with peritonitis tracking into the scrotal sacs was arrived at. Conclusions CNS may have a rare presentation with distracting symptoms of scrotal cellulitis and epididymo-orchitis, as seen in our patient. However, diligent use of abdomino-scrotal sonography, supported by relevant laboratory data can clinch the accurate diagnosis. PMID:27757175

  13. Validation of a disease model in Japanese quail (Coturnix coturnix japonica) with the use of Escherichia coli serogroup O2 isolated from a turkey.

    Science.gov (United States)

    Nain, Sukhbir; Smits, Judit E G

    2011-07-01

    This study established a disease model and protocol for bacterial challenge with Escherichia coli serogroup O2 strain EC317 in Japanese quail. Five groups of 10 birds each were injected subcutaneously in the breast with 200 μL of a brain-heart infusion (BHI) culture containing 1 × 10(8), 1 × 10(7), 1 × 10(6), 1 × 10(5), or 1 × 10(4) colony-forming units/mL of the test organism, which had been isolated from a turkey with cellulitis and septicemia. Birds in a 6th group were controls that received sterile BHI alone. Localized lesions of cellulitis developed in all of the birds that received E. coli. The morbidity and mortality rates were highest (100%) in the birds receiving the highest dose of E. coli and decreased linearly with decreasing dose (P coli. These findings indicate that this disease challenge protocol can be used to study disease resistance and immunologic consequences of contaminant exposure or other stressors in birds.

  14. Bureau de documentation TS/EL/DO

    CERN Document Server

    Dujardin, M

    2004-01-01

    Le bureau de documentation a comme responsabilité de fournir et manager toute la documentation nécessaire au groupe TS-EL. Ce travail utilise des outils CAO (EUCLID- AUTOCAD) et de gestion de base de donnés ORACLE (GESMAR,EDMS) largement utilisé dans le département TS mais aussi des applications métiers tel que le transfert des donnés CAO vers les bases de données, le cheminement automatique ou la schématique électrique. La section se concentre sur des études de grands ensembles et l'intégration 3D des équipements électriques. Les études de services généraux sont généralement sous-traitées. Le projet LHC occupe actuellement la quasi totalité de nos ressources. Pour mener à bien les études électriques du LHC, caractérisées par une définition tardive des besoins et de nombreuses modifications, une structure souple et réactive a été mis en place : Une cellule CAO 3D EUCLID, en charge des layouts d'équipements et des cheminements, en relation avec l'intégration, et une cellule d'é...

  15. Puffy Hand Syndrome Revealed by a Severe Staphylococcal Skin Infection

    Directory of Open Access Journals (Sweden)

    Reyhan Amode

    2013-01-01

    Full Text Available Puffy hand syndrome develops after long-term intravenous drug addiction. It is characterized by a nonpitting edema, affecting the dorsal side of fingers and hands with puffy aspect. Frequency and severity of the complications of this syndrome are rarely reported. Local infectious complications such as cellulitis can be severe and can enable the diagnosis. Herein, we report the case of a 41-year-old man who went to the emergency department for abdominal pain, fever, and bullous lesions of legs and arms with edema. Bacteriologic examination of a closed bullous lesion evidenced a methicillin sensitive Staphylococcus aureus. The abdomen computed tomography excluded deep infections and peritoneal effusion. The patient was successfully treated by intravenous oxacillin and clindamycin. He had a previous history of intravenous heroin addiction. We retained the diagnosis of puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement mimicking a four limbs cellulitis. Puffy hand syndrome, apart from the chronic lymphedema treatment, has no specific medication available. Prophylactic measures against skin infections are essential.

  16. Obesity-related Risk Factors in Implant-based Breast Reconstruction Using AlloDerm

    Science.gov (United States)

    Coleman, Cathryn A.; Erickson, Stephen W.

    2017-01-01

    With a population in which 70% of the patients were overweight or obese, we reviewed retrospectively 135 breasts of 70 consecutive patients who underwent implant-based immediate breast reconstruction using freeze-dried AlloDerm as the acellular dermal matrix. Several obesity-related parameters were evaluated to determine their possible correlation to early postoperative complications. We found that breast width and surface area of AlloDerm usage correlated with the development of infection and mastectomy skin flap necrosis. Increased breast width and size of AlloDerm matrix implanted were correlated with higher rates of both minor and significant skin necrosis and of cellulitis. Body mass index was correlated with the development of cellulitis and minor and major skin necrosis but not with seroma or reconstruction failure. Preexisting breast cup size correlated with the development of seroma but not the other complications. We observed no statistically significant association between reconstruction failure and any of the parameters reviewed, but this is likely due to the small number of failures in our data set (n = 10). PMID:28280672

  17. Pneumonia and disseminated bacteremia with Pasteurella multocida in the immune competent host: A case report and a review of the literature

    Directory of Open Access Journals (Sweden)

    Jason Ferreira

    2015-01-01

    Full Text Available Pasteurella multocida is primarily an opportunistic infection, most commonly of skin and soft tissue following animal bites particularly in the elderly and immunocompromised. While invasive disease with P. multocida has been documented in patients at high risk, such as those with organ transplants, malignancy, and cirrhosis, infections other than cellulitis associated with this pathogen are exceedingly rare in the immunocompetent population. We report a 70 year old Caucasian female with occurrence of a P. multocida pneumonia and resultant bacteremia in an immunocompetent host. Similar to prior case studies, the patient presented with a history of having significant exposure to animals at her residence. We undertook a review of the literature for reports of disseminated P. multocida in immunocompotent hosts in the absence of the typical presentation of cellulitis. Literature has suggested the possibility of nasal and oropharyngeal colonization of patients with frequent interactions with domestic animals, in whom periods of suppressed immune function may lead to activation of infection. P. multocida is commonly susceptible to most beta-lactams, including those utilized for the treatment of community acquired pneumonia. The utilization of macrolides should be avoided in these patients as susceptibilities are unpredictable, however fluoroquinolones maintain activity and may be an alternative therapy.

  18. Computed Tomography Findings in Deep Neck Infections in Children

    Directory of Open Access Journals (Sweden)

    Ayşe Seçil Ekşioğlu

    2014-03-01

    Full Text Available Aim: This study aims to review the computed tomography (CT findings in children with deep neck infections. The crucial role of CT in the diagnosis is emphasized. Methods: Contrast enhanced CT images and medical records of twelve children (4 girls, 8 boys, age range: 1-14 years, mean age: 9 diagnosed with deep neck infection were retrospectively evaluated. Positive CT findings of deep neck infection were: cellulitis, increased fatty tissue echogenicity, loss of soft tissue planes, myositis, and necrotic lymphadenopathy; presence of phlegmon, peritonsillar, retropharyngeal or parapharyngeal abscess. The first four findings were considered as ‘early findings’ while the presence of an abscess indicated advanced infection and was solely enough to make a diagnosis. Results: 42% of the children with deep neck infections had necrotic cervical lymphadenopathies. 5 children (52% had cellulitis, 11 (92% had increased fatty tissue dansity, and 6 (50% children had myositis. Deep neck abscesses (3 retropharyngeal, 4 parapharyngeal, 2 peritonsillar were depicted in 7 children and phlegmon in one child. 2 patients had combined parapharyngeal/retropharyngeal abscesses. The most frequent type was parapharyngeal abcess. Conclusion: CT imaging has a crucial role in the diagnosis and follow-up of deep neck infections in children and is the preferred modality of choice. (The Me­di­cal Bul­le­tin of Ha­se­ki 2014; 52: 34-8

  19. The use of ultrasonography in diagnosis and management of superficial fascial space infections

    Directory of Open Access Journals (Sweden)

    Pravin U Mukhi

    2012-01-01

    Materials and Methods: a total of 26 patients with acute facial swellings were included in the study. Clinical examination confirmed the presence of space infection. Ultrasonographic examination of the swelling was then performed. If ultrasound images showed no collection and only thickness of subcutaneous tissue and muscle involved were increased, then the diagnosis was made as cellulitis. When collection was identified, diagnosis was made as abscess. Dimensions of abscess cavity, amount of pus collected, and depth of the center of the abscess cavity from the skin surface were recorded. Pus evacuation was then prime consideration either by needle aspiration or by incision and drainage. The amount of collection recorded on ultrasonography was compared with that drained at the time of surgery. Results: of 26 patients, 14 patients were diagnosed with cellulitis and the remaining 12 patients with abscesses in the maxillofacial region. Five of 12 cases of abscess were managed with ultrasound-guided needle aspiration; rest seven cases underwent the incision and drainage procedure. Clinical specificity (69.23% was found to be poorer than ultrasound specificity (100 %, both clinical and ultrasound showed the same percentage of sensitivity (92.30% Conclusions: from our experience we can conclude that ultrasonography is an inexpensive and non-invasive diagnostic technique that should be used to supplement clinical examination in patients with superficial fascial space infection.

  20. Masse rénale avec image stellaire centrale: Quel est votre diagnostic?

    Directory of Open Access Journals (Sweden)

    A. Qarro

    2013-03-01

    Full Text Available Le carcinome chromophobe se voit essentiellement à la cinquième décennie et représente 5% des tumeurs rénales. Il existe deux sous types de cancer à cellules chromophobes: le type clair (70% et le type éosinophile. La variante à cellules éosinophiles doit être distinguée de l'oncocytome. Ce dernier se caractérise par une cicatrice fibreuse centrale d'aspect stellaire. Le carcinome chromophobe et l'oncocytome peuvent même coexister dans le cadre du syndrome de Birt-Hogg-Dubé. Certaines tumeurs appelées hybrides partagent des caractéristiques architecturales et cytologiques de ces deux tumeurs. Le pronostic du carcinome chromophobe est favorable. Il est le plus souvent limité au rein et de bas grade nucléaire. Il semblerait donc licite dans les cas ou un examen extemporané mettrait en évidence une tumeur chromophobe, de limiter l'intervention à une néphrectomie partielle si techniquement réalisable.

  1. Superoxide anions produced by Streptococcus pyogenes group A-stimulated keratinocytes are responsible for cellular necrosis and bacterial growth inhibition.

    Science.gov (United States)

    Regnier, Elodie; Grange, Philippe A; Ollagnier, Guillaume; Crickx, Etienne; Elie, Laetitia; Chouzenoux, Sandrine; Weill, Bernard; Plainvert, Céline; Poyart, Claire; Batteux, Frédéric; Dupin, Nicolas

    2016-02-01

    Gram-positive Streptococcus pyogenes (group A Streptococcus or GAS) is a major skin pathogen and interacts with keratinocytes in cutaneous tissues. GAS can cause diverse suppurative and inflammatory infections, such as cellulitis, a common acute bacterial dermo-hypodermitis with a high morbidity. Bacterial isolation yields from the lesions are low despite the strong local inflammation observed, raising numerous questions about the pathogenesis of the infection. Using an in vitro model of GAS-infected keratinocytes, we show that the major ROS produced is the superoxide anion ([Formula: see text]), and that its production is time- and dose-dependent. Using specific modulators of ROS production, we show that [Formula: see text] is mainly synthesized by the cytoplasmic NADPH oxidase. Superoxide anion production leads to keratinocyte necrosis but incomplete inhibition of GAS growth, suggesting that GAS may be partially resistant to the oxidative burst. In conclusion, GAS-stimulated keratinocytes are able to develop an innate immune response based on the production of ROS. This local immune response limits GAS development and induces keratinocyte cell death, resulting in the skin lesions observed in patients with cellulitis.

  2. Evidence for increasing severity of community-onset boils and abscesses in UK General Practice.

    Science.gov (United States)

    Shallcross, L J; Hayward, A C; Johnson, A M; Petersen, I

    2015-08-01

    In England, hospital admissions for severe staphylococcal boils and abscesses trebled between 1989 and 2004. We investigated this trend using routine data from primary and secondary care. We used The Health Improvement Network (THIN), a large primary-care database and national data on hospital admissions from Hospital Episode Statistics (HES). Time trends in the incidence of primary-care consultations for boils and abscesses were estimated for 1995-2010. HES data were used to calculate age-standardized hospital admission rates for boils, abscesses and cellulitis. The incidence of boil or abscess was 450 [95% confidence interval (CI) 447-452] per 100 000 person-years and increased slightly over the study period (incidence rate ratio 1·005, 95% CI 1·004-1·007). The rate of repeat consultation for a boil or abscess increased from 66 (95% CI 59-73) per 100 000 person-years in 1995 to peak at 97 (95% CI 94-101) per 100 000 person-years in 2006, remaining stable thereafter. Hospital admissions for abscesses, carbuncles, furuncles and cellulitis almost doubled, from 123 admissions per 100 000 in 1998/1999 to 236 admissions per 100 000 in 2010/2011. Rising hospitalization and recurrence rates set against a background of stable community incidence suggests increased disease severity. Patients may be experiencing more severe and recurrent staphylococcal skin disease with limited treatment options.

  3. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  4. Parameterization and Observability Analysis of Scalable Battery Clusters for Onboard Thermal Management Paramétrage et analyse d’observabilité de clusters de batteries de taille variable pour une gestion thermique embarquée

    Directory of Open Access Journals (Sweden)

    Lin Xinfan

    2013-03-01

    Full Text Available Although the battery surface temperature is commonly measured, the core temperature of a cell may be much higher hence more critical than the surface temperature. The core temperature of a battery, though usually unmeasured in commercial applications, can be estimated by an observer, based on a lumped-parameter battery thermal model and the measurement of the current and the surface temperature. Even with a closed loop observer based on the measured surface temperature, the accuracy of the core temperature estimation depends on the model parameters. For such purpose, an online parameterization methodology and an adaptive observer are designed for a cylindrical battery. The single cell thermal model is then scaled up to create a battery cluster model to investigate the temperature pattern of the cluster. The modeled thermal interconnections between cells include cell to cell heat conduction and convection to the surrounding coolant flow. An observability analysis is performed on the cluster before designing a closed loop observer for the pack. Based on the analysis, guidelines for determining the minimum number of required sensors and their exact locations are derived that guarantee the observability of all temperature states. Bien que la température de surface d’une batterie soit généralement mesurée, la température interne d’une cellule peut être beaucoup plus élevée donc plus critique que la température de surface. La température interne d’une batterie, pourtant normalement non mesurée dans les applications commerciales, peut être évaluée par un observateur, sur la base d’un modèle thermique de batterie à constantes localisées et à partir de la mesure du courant et de la température de surface. Même avec un observateur en boucle fermée basé sur la température de surface mesurée, la précision de l’estimation de la température interne dépend des constantes du modèle. Dans cette optique, une méthodologie de

  5. Gastric paraganglioma: a case report and a review of the literature.

    Science.gov (United States)

    Pruiti, Vincenzo; Mazzeo, Francesca; Rossitto, Maurizio; Foti, Agata; Macrì, Antonio; Cucinotta, Eugenio

    2014-12-29

    I paragangliomi sono tumori neuroendocrini derivati dalla cresta neurale, provenienti dai paragangli, organi neuroendocrini dispersi e caratterizzati da cellule producenti catecolamine e peptidi. Presentano un’incidenza annuale stimata in 1 / 100.000, rappresentando il 10% dei tumori secernenti catecolamine. Riportiamo il caso di un uomo di 76 anni giunto alla nostra osservazione per la presenza di una lesione polipoide di 4 cm, vegetativaulcerata, tra il corpo e dell’antro gastrico rilevata durante una gastroscopia per la comparsa di anemia. Il paziente è stato sottoposto a gastrectomia subtotale con omentectomia e anastomosi gastrodigiunale. L’esame istologico ha rivelato un carcinoma gastrico polipoide ulcerato con cellule scarsamente aderenti con infiltrazione della parete gastrica muscolare e incidentalmente è stata identificata una lesione della parete gastrica posteriore incidentale che si rilevava essre un paraganglioma con la positività alle indagini di immunocitochimica per NSE e negatività per CD117, S100, CD34 e SMA. Con il termine di feocromocitoma si indica esclusivamente i tumori derivanti dalla midollare del surrene, mentre il paraganglioma extra-surrenalico suggerisce tumori delle cellule cromaffini con altre posizioni. La localizzazione gastrica o perigastrica, come nel nostro caso, è molto rara per queste neoplasie, e in letteratura vi sono solo pochi case report. La predisposizione genetica si osserva nel 30% di questi tumori e può essere responsabile della malattia ereditaria caratterizzata da differenze nella distribuzione del tumore, nella produzione di catecolamine, nel rischio di metastasi, e nell’associazione con altri tipi di tumori. In conclusione, nei pazienti con sintomi di tumore secernente cromaffini o in pazienti con una storia familiare di feocromocitoma-paraganglioma, che portano mutazioni e sottoposti a screening per il tumore asintomatico, la prima indagine diagnostica è determinare i livelli di metanefrina

  6. Extension of centered hydrodynamical schemes to unstructured deforming conical meshes : the case of circles

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    Bernard-Champmartin Aude

    2013-01-01

    Full Text Available In a prior work [CEMRACS10], a curvilinear bi-dimensional finite volume extension of Lagrangian centered schemes GLACE [GLACE] on unstructured cells, whose edges are parameterized by rational quadratic Bézier curves was proposed and we showed numerical results for this scheme. Now, we extend the EUCCLHYD scheme [EUCCLHYD] to these cells. To simulate flows with evolving large deformations, we write a formalism allowing the time evolution of the conic parameter. As an example, this allows an edge changing from an ellipse segment to a hyperbolic one. In this framework, we consider the case of a mesh whose edges are circle segments with non fixed centers. We show that this formalism extends also the previous work [GLACE CIRCLE] (which is equivalent to [CEMRACS10] when conic edges are all circles. This is a necessary first step toward general conical deformation. Dans un travail précédent [CEMRACS10], une extension volume fini bi-dimensionnelle curviligne du schéma Lagrangien centré GLACE [GLACE] sur des cellules non structurées dont les bords sont paramétrés par des courbes de Bézier quadratiques rationnelles a été proposée. Maintenant, nous proposons une extension du schéma EUCCLHYD [EUCCLHYD] à ce type de cellules et pour lequel nous montrons quelques résultats numériques. Pour pouvoir suivre un écoulement subissant de grandes variations de forme, nous écrivons un formalisme qui permet l’évolution en temps du paramètre de chaque conique. Ainsi, un bord de maille peut d’un segment d’ellipse devenir en cours de calcul un segment d’hyperbole. Dans ce cadre, nous considérons le cas particulier d’un maillage dont les bords de cellules sont des arcs de cercle avec des centres non fixes. Nous montrons que ce formalisme constitue également une extension directe d’un travail précédent [GLACE CIRCLE] (qui équivaut à [CEMRACS10] dans le cas où les bords coniques sont tous des cercles. Ce résultat constitue une

  7. Extension of ALE methodology to unstructured conical meshes

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    Hoch Philippe

    2011-11-01

    Full Text Available We propose a bi-dimensional finite volume extension of a continuous ALE method on unstructured cells whose edges are parameterized by rational quadratic Bezier curves. For each edge, the control point possess a weight that permits to represent any conic (see for example [LIGACH] and thanks to [WAGUSEDE,WAGU], we are able to compute the exact area of our cells. We then give an extension of scheme for remapping step based on volume fluxing [MARSHA] and self-intersection flux [ALE2DHAL]. For the rezoning phase, we propose a three step process based on moving nodes, followed by control point and weight re-adjustment. Finally, for the hydrodynamic step, we present the GLACE scheme [GLACE] extension (at first-order on conic cell using the same formalism. We only propose some preliminary first-order simulations for each steps: Remap, Pure Lagrangian and finally ALE (rezoning and remapping. Nous proposons une extension volumes finis bi-dimensionnelle d’une méthode ALE continue sur des cellules non structurées dont les bords sont paramétrés par des courbes de Bézier quadratiques rationnelles. Pour chaque arête, le point de contrôle possède un poids qui permet de représenter n’importe quelle conique [LIGACH] et grâce à [WAGUSEDE,WAGU], nous pouvons calculer l’aire exacte de nos cellules. Pour la phase de remapping, on donne l’extension de deux schéma, l’un basé sur le calcul de flux de volumes [MARSHA] et l’autre par flux avec auto-intersection [ALE2DHAL]. Pour la phase de lissage de maillage, nous proposons un processus en trois étapes basées sur le déplacement des noeuds, suivi de celui des points de contrôle puis finalement du rajustement du poids. Enfin, pour la phase hydrodynamique, on présente l’extension du schéma GLACE [GLACE] (à l’ordre un sur les cellules coniques en utilisant le même formalisme. Nous montrons seulement des simulations préliminairesl’ordre 1 sur chaque tape : Remap, Lagrange pur et ALE

  8. 13例重症口腔颌面部蜂窝组织炎临床分析

    Institute of Scientific and Technical Information of China (English)

    王天霆; 李织; 张红玲; 孙巍

    2012-01-01

      Objective To investigate the clinical features and multidisciplinary joint treatment of the severe cellulitis of the oral and maxillofacial regions. Methods By conducting a comprehensive analysis of its pathogenesis, clinical manifestations and the laboratory test results on 13 cases of the severe cellulitis of the oral and maxillofacial regions, to observe the local and systemic treatment effect given by multidisciplinary joint treatment. Results In 13 cases,10 cases were cured,2 cases were died. Conclusion The severe cellulitis of the oral and maxillofacial regions onset acute, development quick, symptom heavy and lead to serious consequences. Taking multidisciplinary joint disposal, combine active anti-infection with early surgical incision and drainage, and use treatment which take the whole body and the local into account, these methods can achieve good clinical curative effect. While early and effective prevention of complications is the key to reduce mortality.%  目的探讨重症口腔颌面部蜂窝组织炎的临床特征及多学科联合治疗方法。方法对临床收治的13例重症口腔颌面部蜂窝组织炎患者的病因、临床表现和实验室检查结果等进行综合分析,观察其多学科联合处置的局部和全身治疗效果。结果本组13例患者,10例痊愈,2例死亡。结论重症口腔颌面部蜂窝组织炎起病急、发展快、症状重、后果严重;采取多学科联合处置、积极抗感染与尽早手术切开引流相结合、全身与局部兼顾的治疗方法,可取得较好的临床疗效;而早期有效地预防并发症的发生是降低病死率的关键。

  9. Variation in antibiotic treatment for diabetic patients with serious foot infections: A retrospective observational study

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    Christiansen Cindy L

    2010-07-01

    Full Text Available Abstract Background Diabetic foot infections are common, serious, and diverse. There is uncertainty about optimal antibiotic treatment, and probably substantial variation in practice. Our aim was to document whether this is the case: A finding that would raise questions about the comparative cost-effectiveness of different regimens and also open the possibility of examining costs and outcomes to determine which should be preferred. Methods We used the Veterans Health Administration (VA Diabetes Epidemiology Cohorts (DEpiC database to conduct a retrospective observational study of hospitalized patients with diabetic foot infections. DEpiC contains computerized VA and Medicare patient-level data for VA patients with diabetes since 1998, including demographics, ICD-9-CM diagnostic codes, antibiotics prescribed, and VA facility. We identified all patients with ICD-9-CM codes for cellulitis/abscess of the foot and then sub-grouped them according to whether they had cellulitis/abscess plus codes for gangrene, osteomyelitis, skin ulcer, or none of these. For each facility, we determined: 1 The proportion of patients treated with an antibiotic and the initial route of administration; 2 The first antibiotic regimen prescribed for each patient, defined as treatment with the same antibiotic, or combination of antibiotics, for at least 5 continuous days; and 3 The antibacterial spectrum of the first regimen. Results We identified 3,792 patients with cellulitis/abscess of the foot either alone (16.4%, or with ulcer (32.6%, osteomyelitis (19.0% or gangrene (32.0%. Antibiotics were prescribed for 98.9%. At least 5 continuous days of treatment with an unchanged regimen of one or more antibiotics was prescribed for 59.3%. The means and (ranges across facilities of the three most common regimens were: 16.4%, (22.8%; 15.7%, (36.1%; and 10.8%, (50.5%. The range of variation across facilities proved substantially greater than that across the different categories of

  10. Necrotizing black tattoo reaction: what's in a name?

    Science.gov (United States)

    Bhogal, Ricky Harminder; Thomas, Sunil Solomon

    2009-01-01

    We report the rare case of an 18-year-old man who developed a necrotizing cutaneous reaction 5 days after having a permanent black tattoo on his left forearm spelling his name. Three cases of reactions to permanent black tattoos have been reported within the literature. These cases described the development of cellulitis of the skin adjacent to the tattoo but none reported florid necrotizing cutaneous reactions. The initial management with oral antibacterials failed to resolve the symptoms and use of intravenous antibacterials and topical corticosteroids was needed. Six weeks after presentation the tattoo lettering showed the presence of hyperpigmented skin. Subsequent patch testing confirmed that the patient had no allergy to black tattoo pigments suggesting that the necrotizing cutaneous reaction was secondary to infection. We show that successful treatment of this rare infective complication of permanent black tattoos involves the early institution of intravenous antibacterial agents and topical corticosteroids.

  11. Diabetic muscle infarction in a 57 year old male: a case report

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    Litvinov Ivan V

    2012-12-01

    Full Text Available Abstract Background Diabetic muscle infarction is a rare complication of diabetes mellitus (DM and is often misdiagnosed as cellulitis. This complication is usually associated with poor disease prognosis and high mortality with previous studies reporting a risk of 50% recurrence or another macrovascular complication occurring within one year. Thus, there needs to be greater awareness of this complication of diabetes. Case presentation In the current work, we present a case report and literature review of DMI occurring in a calf of a 57 year old male. However, unlike the suspected trend, our patient has performed well after this incident and has not sustained another macrovascular event now > 15 month since his original diabetic muscle infarction. Conclusion Even though diabetic muscle infarction is an uncommon condition, it is important to consider this diagnosis in a diabetic patient. We hope that our findings and literature review will aid clinicians to better diagnose and manage this condition.

  12. Métabolisme et fonctions de l’acide myristique

    OpenAIRE

    Rioux Vincent; Legrand Philippe

    2001-01-01

    L’acide myristique (C:14:0) est un acide gras saturé d’origine alimentaire ou d’origine endogène, encore peu connu. Il a des spécificités métaboliques et fonctionnelles qui sont présentées ici. Il possède un avenir court dans la cellule puisqu’il est majoritairement beta-oxydé et/ou allongé en acide palmitique. Il a également, en acylant plusieurs protéines (myristoylation), des rôles fonctionnels très importants dans la régulation de certaines fonctions cellulaires.

  13. Langerhans cell histiocytosis with presentation as orbital disease

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    Ashok B Bhanage

    2015-01-01

    Full Text Available Langerhans cell histiocytosis (LCH is an uncommon multisystem disease with an abnormal polyclonal proliferation of Langerhans cells that invade various organs. In rare instances, the affection of the orbit is the only and the first symptom. We report an unusual case of an 18-month-old male who presented with orbital disease as the first symptom, in the form of chronic presentation of periorbital swelling (2 months duration with acute inflammation (1-week duration giving a suspicion of orbital cellulitis. Histopathology after radical excision confirmed the diagnosis of LCH and was advised initial therapy as per Histiocyte Society Evaluation and Treatment Guidelines (2009 but was lost to follow-up only reappearing with progression (multisystem LCH with risk organ involvement and developed progressive active disease on treatment after 5 weeks. He was treated with salvage therapy for risk patients achieving complete remission.

  14. Langerhans cell histiocytosis with presentation as orbital disease

    Science.gov (United States)

    Bhanage, Ashok B.; Katkar, Anand D.; Ghate, Prajakta S.

    2015-01-01

    Langerhans cell histiocytosis (LCH) is an uncommon multisystem disease with an abnormal polyclonal proliferation of Langerhans cells that invade various organs. In rare instances, the affection of the orbit is the only and the first symptom. We report an unusual case of an 18-month-old male who presented with orbital disease as the first symptom, in the form of chronic presentation of periorbital swelling (2 months duration) with acute inflammation (1-week duration) giving a suspicion of orbital cellulitis. Histopathology after radical excision confirmed the diagnosis of LCH and was advised initial therapy as per Histiocyte Society Evaluation and Treatment Guidelines (2009) but was lost to follow-up only reappearing with progression (multisystem LCH with risk organ involvement) and developed progressive active disease on treatment after 5 weeks. He was treated with salvage therapy for risk patients achieving complete remission. PMID:26167225

  15. Involvement of Maged1 in motor behaviour and drug addiction

    OpenAIRE

    De Backer, Jean-François

    2015-01-01

    Maged1 appartient à la famille des gènes Mage (pour Melanoma antigen gene). Bien que les gènes Mage aient tout d'abord été découverts dans des cellules tumorales, le gène Maged1 est également exprimé dans un grand nombre de tissus sains et particulièrement dans le système nerveux central, aussi bien au cours du développement que chez l'animal adulte. Les fonctions exercées par la protéine Maged1 dans le système nerveux restent actuellement fort méconnues bien que des études aient pu mettre en...

  16. Poliovirus et Apoptose

    OpenAIRE

    2007-01-01

    Le poliovirus est l'agent responsable de la poliomyélite paralytique aigüe. Les paralysies flasques caractéristiques de la poliomyélite résultent de la destruction des neurones moteurs, les cellules cibles spécifiques du poliovirus dans le système nerveux central (SNC). Le développement de nouveaux modèles animaux et cellulaires a permis d'étudier les étapes clés de la pathogénèse de la poliomyélite à un niveau moléculaire. En particulier il a été montré chez la souris que l'induction de l'ap...

  17. Etude et description d'un nouveau thermofluxmètre permettant la mesure simultanée des flux thermiques et des variations de température

    OpenAIRE

    Ravalitera, G.; Cornet, M.; Duthoit, B.; Thery, P.

    1982-01-01

    Les résultats concernant l'effet thermoélectrique dans les feuilles minces recouvertes d'un dépôt électrolytique ont permis la réalisation de plusieurs types de cellules fluxmétriques. Une thermopile de conception nouvelle a été réalisée en intégrant un grand nombre de thermoéléments sur une feuille conductrice de faible épaisseur. La tension apparaissant aux bornes du circuit thermoélectrique est proportionnelle au flux thermique traversant la surface de mesure. La résistance interne varie a...

  18. Développement durable : environnement, énergie et société

    OpenAIRE

    Tarascon, Jean-Marie

    2014-01-01

    Enseignement. Biodiversité, ses croisements avec l’humanité Leçon inaugurale. Biodiversité : de l’océan et la forêt, à la cité (19 décembre 2013) Bâtie sur la chimie pré-biotique issue d’une géo-diversité antérieure, la biodiversité est née dans l’océan ancestral vers 3850 millions d’années (Ma), quand les premières cellules se sont clonées par scissiparité. La vie s’est ensuite diversifiée dans l’océan durant des milliards et des centaines de millions d’années et se sont alors produits des é...

  19. Etudes physiques des mélanges eau-cryoprotecteurs

    Science.gov (United States)

    Vassoille, R.; Perez, J.

    The aim of the following review is to present the most important studies concerning the physical properties of water-solutes mixtures used in cryobiology. Cryobiology is a branch of biology which deals with the very low temperature behaviour of cells. This technique is developed today in several directions. The creation of banks of cells and perhaps in a short time of small organs, is the purpose of much research in this domain. Before freezing, living cells are generally put in a solution containing one or more solutes. The role of these solutes is to protect the cells against damage due to crystallization of water (cryoprotectors). The mechanisms of cryoprotection are not well known ; nevertheless the vitreous state formation during cooling is often invoked. So, it is possible to avoid crystallization damage such as mechanical strain (due to an increase of volume of about 10 %) and salt effects (due to osmotic pressure). The conditions in which the vitreous state is obtained, maintained during cooling, storage at low temperature and rewarming can be defined by physical studies presented in the following review. Le présent travail est essentiellement une revue bibliographique des principales études physiques qui ont été réalisées avec des solutions de composés habituellement employés en cryobiologie. La cryobiologie est une branche de la biologie qui s'intéresse au comportement des cellules à basse température. Cette discipline est actuellement en plein développement dans des domaines très divers. Son principal but est la création de banques de cellules de plus en plus complexes avec comme perspective la conservation des organes. Les cellules vivantes sont généralement placées avant congélation dans une solution contenant divers composés dont le rôle est de protéger les cellules contre les effets de la cristallisation de l'eau. L'action protectrice de ces cryoprotecteurs est encore mal connue; cependant, la formation d'un état vitreux lors du

  20. Usefulness of Infrared Thermal Imaging Camera for Screening of Postoperative Surgical Site Infection after the Nuss Procedure

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    Kenya Fujita

    2013-01-01

    Full Text Available Introduction and Objective. The Nuss procedure is widely used in the treatment of pectus excavatum worldwide. Postoperative pectus bar infection is one of the most serious complications associated with this procedure. Therefore, early detection of signs of implant infection is very important. However, this is difficult, and effective methods have yet to be established. Methods. We use a handheld infrared thermal imaging camera to screen patients for postoperative infection following the Nuss procedure. Here, we report a 28-year-old man with recurrent postoperative (Ravitch procedure pectus excavatum. Results. Infrared thermography camera clearly indicated slight cellulitis in the right chest. Conclusion. Our technique may assist in preventing postoperative bar infection and removal caused by severe bar infection. Furthermore, this camera is potentially suitable for many situations in infection monitoring following subcutaneous implant surgery.

  1. Angiosarcoma Presenting with Minor Erythema and Swelling

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    Catherine A. Cox

    2013-04-01

    Full Text Available A 76-year-old man presented with slowly progressive swelling in his forehead and left upper eyelid over the course of three months. CT scanning showed non-specific enhancement of subcutaneous tissues, suggesting a low-grade cellulitis. Poor response to treatment prompted an MRI, which revealed the presence of a soft tissue lesion. Biopsy of this lesion was positive for angiosarcoma. The patient underwent chemotherapy and radiation, but unfortunately succumbed to his malignancy eight months later. This case illustrates a rare example of facial/periorbital angiosarcoma, a benign-appearing but aggressive tumor associated with a high incidence of mortality. A review of the literature and current treatment options are discussed.

  2. Juvenile sterile granulomatous dermatitis (puppy strangle in Pekingese and German shepherd puppies

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    Mohammad Abbaszadeh Hasiri

    2015-07-01

    Full Text Available Juvenile sterile granulomatous dermatitis is an uncommon granulomatous and pustular disorder of the face, pinnae, and submandibular lymph nodes of puppies. A 10-week-old male Pekingese and a 8-week-old female German shepherd presented with submandibular lymphadenomegaly, skin lesions on muzzle and periocular area (Papules, crusts and pustules. The case did not respond to antibiotic therapy. Results of a hemogram, biochemical panel, and urinalysis were normal. Due to skin scraping, cytology examination (impression smear, fungal and bacterial culture and response to therapy puppy strangle (juvenile cellulitis was diagnosed. The puppies made a full recovery on glucocorticoid therapy. The present case report describes the first report of juvenile sterile granulomatous dermatitis in Iran.

  3. Biotechnologies de la reproduction : le clonage des animaux d'élevage

    OpenAIRE

    Vignon, Xavier; Heyman, Yvan; Chavatte Palmer, Pascale; Renard, Jean Paul

    2008-01-01

    La reproduction d’espèces domestiques par clonage remonte à plus de 20 ans. Les premières techniques reposent sur la bissection d’embryons puis sur l’usage de cellules embryonnaires pour générer des animaux clonés par transfert de noyau. Avec l’apparition du clonage somatique, qui permet la préservation et l’obtention de descendants de génotypes de haute valeur, l’intérêt pour cette technologie s’est considérablement accru. Un retour sur ces 20 dernières années montre comment l’INRA s’est imp...

  4. Il XLIV Congresso della Società Italiana di Reumatologia

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    F. Oliviero

    2011-09-01

    Full Text Available Il 17-20 Ottobre 2007 al Lido di Venezia presso il Palazzo del Casinò e il Palazzo del Cinema si è svolto il XLIV Congresso Nazionale della Società Italiana di Reumatologia (SIR. Numerosi esperti nazionali e internazionali hanno esposto le più importanti acquisizioni nel campo della ricerca clinica e di base reumatologiche. I tre giorni del congresso sono stati caratterizzati da letture, sessioni scientifiche, corsi educazionali, incontri con gli esperti, sezioni poster, corsi di aggiornamento su temi speciali, e diversi simposi. Tra i temi affrontati, particolare rilievo è stato dedicato ai singoli fattori implicati nella patogenesi delle malattie reumatiche, quali le citochine, i fagociti, le cellule endoteliali, i linfociti, i fibroblasti e gli autoanticorpi. In questo ambito un contributo di rilievo è stato offerto dai numerosi relatori stranieri ospiti del convegno. Dal punto di vista clinico, sono...

  5. Death due to an unrecognized groin abscess in a drug addict: a retrospective study.

    Science.gov (United States)

    D'Ovidio, Cristian; Vellante, Paola; Costantini, Sara; Carnevale, Aldo

    2013-07-01

    Intravenous drug injection persists despite health risks and medical complications. Venous thrombosis, septic thrombophlebitis, artery necrosis, arterio-venous fistula, mycotic aneurysm, dissecting hematoma, pseudoaneurysm formation, and soft tissues infections (i.e. abscesses, cellulitis, infected ulcers), are some of the major clinical consequences lives threatening. The aim of this work is to present this unusual autoptic case of a drug addict man died for an unrecognized groin abscess referred to the Institute of Legal Medicine, University of Chieti, causing femoral vein's erosion, and to analyse the most common patterns of vascular lesions among drug addicts. It could be stimulated a new scientific debate because groin injections and their vascular complications increase over years; while soft tissue infections may hide vascular lesions' diagnosis. So physicians should have a high index of suspicion for serious vascular problems, among intravenous drug users (IDUs): prevention for avoiding groin injection and a proper treatment are necessary.

  6. Gastric adenocarcinoma in the context of X-linked agammaglobulinemia: case report and review of the literature.

    Science.gov (United States)

    Staines Boone, Aidé Tamara; Torres Martínez, María Guadalupe; López Herrera, Gabriela; de Leija Portilla, Julia O; Espinosa Padilla, Sara Elva; Espinosa Rosales, Francisco J; Lugo Reyes, Saúl Oswaldo

    2014-02-01

    The hallmarks of X-linked Agammaglobulinemia (XLA) are panhypogammaglobulinemia, absent B-cells, and recurrent sinopulmonary and gastrointestinal infections starting at an early age, as well as other infections like cellulitis, meningitis, arthritis and sepsis. A number of non-infectious complications have been reported in these patients, including autoimmune diseases and malignancy, especially lymphomas. Here, we report the case of a 30-year old man who developed gastric adenocarcinoma in the context of XLA. Previous reports of, and hypotheses addressing the development of cancer in patients with XLA, are also summarized. Solid cancer in XLA affects mainly the gastrointestinal tract and seems to be related to chronic infection. A natural evolution can be traced back from gastric adenocarcinoma to megaloblastic anemia due to achlorhydria in the context of chronic infection; periodic endoscopy thus seems justified to detect and treat carcinoma in early stages.

  7. Use of digital images in the assessment and treatment of pressure ulcers in patients with spinal injuries in community settings.

    Science.gov (United States)

    Sarhan, Firas; Weatherburn, Gwyn; Graham, Allison; Thiyagarajan, Chinnaya

    2010-01-01

    We conducted a retrospective review of the digital images in the clinical records of 50 patients with pressure ulcers. Ten nurses independently assessed one image from each patient. There was a total of 414 responses from the nurses about the stage and location of the ulcers (83% response rate). The average agreement about the stage and location of the ulcers was 85%. The overall agreement declined as the stage of the ulcer increased. The average agreement regarding the wound descriptors was: necrosis 85%, granulation tissue 81%, ischaemia 83%, cellulitis /infection 69%, erythema 68%. Almost all nurses felt the need to change the current management of the wound (460 responses, or 92%). The nurses judged that most digital images were of good quality (17%) or very good quality (79%). The present study suggests that a high percentage of assessments for patients currently travelling to specialist clinics could be performed in the community using digital images and telemedicine.

  8. Etude électrochimique du système Zn-Se en milieu eutectique chlorure de choline-urée

    OpenAIRE

    2014-01-01

    Le présent travail porte sur l’étude de l’électrodéposition du système Zn-Se sur une électrode d’orpolycristallin (Au (poly)) en milieu chlorure de choline – urée (ChCl-U). Le choix de ZnSe est guidé par sesnombreuses applications optiques surtout dans les cellules solaires. Afin de mettre en évidence la formation d’un filmde Zn-Se par électrodéposition, différentes investigations électrochimiques ont été effectuées. La première étape desétudes a permis d’optimiser l’électrodéposition du sélé...

  9. Métabolisme et fonctions de l’acide myristique

    Directory of Open Access Journals (Sweden)

    Rioux Vincent

    2001-03-01

    Full Text Available L’acide myristique (C:14:0 est un acide gras saturé d’origine alimentaire ou d’origine endogène, encore peu connu. Il a des spécificités métaboliques et fonctionnelles qui sont présentées ici. Il possède un avenir court dans la cellule puisqu’il est majoritairement beta-oxydé et/ou allongé en acide palmitique. Il a également, en acylant plusieurs protéines (myristoylation, des rôles fonctionnels très importants dans la régulation de certaines fonctions cellulaires.

  10. Ethmoid osteoma as a culprit of orbital emphysema: a case report.

    Science.gov (United States)

    Zhuang, Ai; Li, Yinwei; Lin, Ming; Shi, Wodong; Fan, Xianqun

    2015-05-01

    Orbital emphysema is generally recognized as a complication of orbital fractures involving any paranasal sinuses. The recognition about its etiology has extended beyond sole trauma, but few articles mentioned tumors to be a possible cause.In this case report, we present a patient with orbital emphysema associated with ethmoid osteoma without orbital cellulitis or trauma history. The patient developed sudden proptosis, eyelid swelling, and movement limitation of the left eye, peripheral diplopia, and left periorbital crepitus after a vigorous nose blowing.Complete surgical resection of ethmoid osteoma followed by repair of the orbital medial wall was performed with assistance of combined endoscopy and navigational techniques. Twelve-month follow-up showed no residual lesion or recurrence; the orbital medial wall was accurately repaired with good visual function and facial symmetry.Tumors should be considered for differential diagnosis of orbital emphysema, and combined endoscopy and navigational techniques may improve safety, accuracy, and effectiveness of orbital surgeries.

  11. Système autolytique de Lactobacillus helveticus

    OpenAIRE

    Jebava-Ondrackova, Iva

    2011-01-01

    L´autolyse est une dégradation du peptidoglycan par des enzymes bactériennes endogènes appelées hydrolases du peptidoglycane ou autolysines. Grâce à cette réaction enzymatique, la cellule bactérienne peut éclater et le contenu intracellulaire est libéré. Chez Lactobacillus helveticus, le ferment protéolytique fromager, les enzymes libérées lors de l´autolyse jouent un rôle important dans le développement de l´arôme et la texture des fromages au cours de l´affinage. Il apparait également que l...

  12. Pyomyositis after vaginal delivery.

    LENUS (Irish Health Repository)

    Gaughan, Eve

    2011-01-01

    Pyomyositis is a purulent infection of skeletal muscle that arises from haematogenous spread, usually with abscess formation. It can develop after a transient bacteraemia of any cause. This type of infection has never been reported before in the literature after vaginal delivery. A 34-year-old woman had progressive severe pain in the left buttock and thigh and weakness in the left lower limb day 1 post spontaneous vaginal delivery. MRI showed severe oedema of the left gluteus, iliacus, piriformis and adductor muscles of the left thigh and a small fluid collection at the left hip joint. She was diagnosed with pyomyositis. She had fever of 37.9°C immediately postpartum and her risk factors for bacteraemia were a mild IV cannula-associated cellulitis and labour itself. She required prolonged treatment with antibiotics before significant clinical improvement was noted.

  13. RNA Origami

    DEFF Research Database (Denmark)

    Sparvath, Steffen Lynge

    2017-01-01

    for biosensorer,  der kan spore enten microRNA’er eller små molekyler, eksemplificeret ved S-adenosylmethionin (SAM). Slutteligt indikerer foreløbige resultater, at apta-FRET SAM sensoren kan udtrykkes i Escherichia coli-celler, hvilket viser, at RNA-origami arkitekturen muliggør cotransskriptionel foldning af......RNA-nanoteknologi feltet har demonstreret alsidigheden af RNA som byggemateriale, og rationelt designede RNA-nanostrukturer er blevet brugt i udviklingen af strukturelle platforme og dynamiske anordninger med anvendelser både in vitro og in vivo. Naturlige RNA-strukturer foldes cotransskriptionelt...... fra en enkelt RNA-streng, og udfører en lang række komplekse cellulære funktioner. Mange af funktionerne er blevet udnyttet til at skabe funktionelle RNA-baserede nanoapparater, men den nuværende litteratur giver kun få eksempler på cotranskriptionel produktion af RNA-nanostrukturer. I 2014...

  14. Structure and dynamics of modulated traveling waves in cellular flames

    CERN Document Server

    Bayliss, A; Riecke, H

    1994-01-01

    We describe spatial and temporal patterns in cylindrical premixed flames in the cellular regime, $Le < 1$, where the Lewis number $Le$ is the ratio of thermal to mass diffusivity of a deficient component of the combustible mixture. A transition from stationary, axisymmetric flames to stationary cellular flames is predicted analytically if $Le$ is decreased below a critical value. We present the results of numerical computations to show that as $Le$ is further decreased traveling waves (TWs) along the flame front arise via an infinite-period bifurcation which breaks the reflection symmetry of the cellular array. Upon further decreasing $Le$ different kinds of periodically modulated traveling waves (MTWs) as well as a branch of quasiperiodically modulated traveling waves (QPMTWs) arise. These transitions are accompanied by the development of different spatial and temporal symmetries including period doublings and period halvings. We also observe the apparently chaotic temporal behavior of a disordered cellul...

  15. Laboratory risk indicators for acute necrotizing fasciitis in the emergency setting

    Institute of Scientific and Technical Information of China (English)

    Syed Shayan Ali; Fatimah Lateef

    2016-01-01

    Necrotizing fasciitis is a rare bacterial skin condition which forms a major diagnostic challenge and is associated with poor prognosis unless promptly treated. Initial clinical presentation is often misleading with characteristic features developing only late in the course of the disease. In this review, we discuss the applicability and usefulness of laboratory risk indicator for necrotizing fasciitis score in facilitating rapid diagnosis of necrotizing fasciitis in emergency department by differentiating it from other skin in-fections like cellulitis and abscesses. A high index of suspicion resulting from the lab-oratory risk indicator for necrotizing fasciitis score can facilitate early diagnosis enabling prompt antibiotic administration and timely referral to surgery for wound debridement, ultimately reducing both the morbidity and mortality.

  16. Canaliculitis in supernumerary puncta and canaliculi

    Directory of Open Access Journals (Sweden)

    Ku Chui Yong

    2011-08-01

    Full Text Available We report the first case of supernumerary puncta and canaliculi presented with canaliculitis. A-59 year-old gentleman presented with painful swelling of the left lower lid for a week, which was associated with epiphora. The swelling was confined to the nasal aspect of the left lower lid (0.5¥0.5 mm with inflamed overlying skin. Two puncta (0.5 mm apart were noted. The outer punctum at the normal anatomical position was a cul-de-sac while the inner punctum it the caruncle was patent. We described the embryology leading to supernumerary puncta and canaliculi to explain the paradoxical patency of the abnormally located punctum as well as the pathomechanism leading to canaliculitis. The patient was treated with oral cloxacillin 500 mg, 6 hourly for 5 days; the cellulitis subsided after three days.

  17. [Abdomen pendulum and subcutaneous injections: the complications. Two case reports].

    Science.gov (United States)

    Benhaim, T; Sinna, R; Garson, S; Boloorchi, A; Crozet, C; Robbe, M

    2007-06-01

    The authors present the complications due to subcutaneous injections on two patients suffering from morbid obesity with an abdomen pendulum. In the first case, injections of heparin of low molecular weight at curative dose, for treatment of a pulmonary embolism, have been complicated with a giant abdominal wall haematoma, the biggest ever reported. The initial treatment was insufficient so we had to practice a dermolipectomy to take off the haematoma of four litters. In the second case, insulin injections were complicated with cellulitis of the abdominal wall and a surgical treatment has been practiced in emergency. The first case reminds us the importance to change the sites of injections and to accommodate the dose, surgical treatment staying as simple as possible. The second case allows us to report a rare complication, not often published but known with obese patients. These two cases illustrate the importance of therapeutic education of the patient and the fact that a simple injection can be life threatening.

  18. Impact de l’âge et du microbiote sur l’expression intestinale des défensines chez les oiseaux

    OpenAIRE

    Bencherit, Djihad; Marty, Hélène; Trotereau, Angelina; Chanteloup, Nathalie; Brée, Annie; Schouler, Catherine

    2012-01-01

    Les défensines aviaires appartiennent à la grande famille des peptides antimicrobiens qui sont des composants clés de l’immunité innée des muqueuses [1]. Ces molécules peuvent être produites par les granulocytes et les cellules épithéliales [2]. Elles peuvent être purifiées à partir de la moelle osseuse du poulet et sont actives contre un panel de souches bactériennes Gram+ et Gram- [3]. L’expression des gènes des deux défensines aviaires majeures (AvBD1 et AvBD2) dans le tissu intestinal es...

  19. Opana ER abuse and thrombotic thrombocytopenic purpura (TTP)-like illness: a rising risk factor in illicit drug users.

    Science.gov (United States)

    Kapila, Aaysha; Chhabra, Lovely; Chaubey, Vinod K; Summers, Jeffery

    2014-03-03

    We report the case of a 22 year-old-woman who presented with upper extremity cellulitis secondary to an infiltration of illicit intravenous drug use. She confessed to the intravenous use of Opana ER (an extended release oral formulation of oxymorphone) which is an opioid drug approved only for oral use. She was found to have clinical evidence of profound thrombotic microangiopathy which resulted due to the intravenous use of Opana ER. She showed full clinical improvement after withholding drug and supportive clinical care. Recent report of Opana ER intravenous abuse was published from Tennessee county and has now been increasingly recognised as one of the causes of thrombocytopenia which mimicks clinically as thrombotic thrombocytopenic purpura. Physicians should be aware of this association as the lack of familiarity to this can pose serious management dilemmas for our patients (especially the polysubstance abusers).

  20. Acute bacterial skin and skin structure infections in internal medicine wards: old and new drugs.

    Science.gov (United States)

    Falcone, Marco; Concia, Ercole; Giusti, Massimo; Mazzone, Antonino; Santini, Claudio; Stefani, Stefania; Violi, Francesco

    2016-08-01

    Skin and soft tissue infections (SSTIs) are a common cause of hospital admission among elderly patients, and traditionally have been divided into complicated and uncomplicated SSTIs. In 2010, the FDA provided a new classification of these infections, and a new category of disease, named acute bacterial skin and skin structure infections (ABSSSIs), has been proposed as an independent clinical entity. ABSSSIs include three entities: cellulitis and erysipelas, wound infections, and major cutaneous abscesses This paper revises the epidemiology of SSTIs and ABSSSIs with regard to etiologies, diagnostic techniques, and clinical presentation in the hospital settings. Particular attention is owed to frail patients with multiple comorbidities and underlying significant disease states, hospitalized on internal medicine wards or residing in nursing homes, who appear to be at increased risk of infection due to multi-drug resistant pathogens and treatment failures. Management of ABSSSIs and SSTIs, including evaluation of the hemodynamic state, surgical intervention and treatment with appropriate antibiotic therapy are extensively discussed.

  1. Report of a patient with acne conglobata and perifolliculitis capitis abscedens et suffodiens

    Directory of Open Access Journals (Sweden)

    Mónica Lorena Cárdenas

    2011-06-01

    Full Text Available Perifoliculitis capitis abscedens et suffodiens, dissecting folliculitis, dissecting cellulitis, or Hoffman disease is a rare, inflammatory and chronic condition, which affects the scalp of young black men, mainly characterized by the appearance of nodules and abscesses that drain purulent material with fistulas and pathways, leading ultimately to scarring alopecia. At present, this condition is defined as a primary disorder of follicular keratinization, being part of the triad or tetrad of follicular occlusion. One third of the cases are associated with acne conglobata as a primary event. Management, frustrating for many years, is promising with the successful use of isotretinoin and a combination of medications that intervene each of its physiopathological principles.

  2. Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Jennifer Wang

    2015-01-01

    Full Text Available Cryptococcus neoformans is an opportunistic yeast present in the environment. Practitioners are familiar with the presentation and management of the most common manifestation of cryptococcal infection, meningoencephalitis, in patients with AIDS or other conditions of immunocompromise. There is less awareness, however, of uncommon presentations where experience rather than evidence guides therapy. We report a case of primary cutaneous cryptococcosis (PCC in a patient who had been immunosuppressed by chronic high-dose corticosteroid for the treatment of severe asthma. This case highlights the importance of early recognition of aggressive cellulitis that fails standard empiric antibiotic treatment in an immunocompromised patient. It also demonstrates successful treatment of PCC with a multispecialty approach including local debridement and fluconazole monotherapy.

  3. Acute allergic angioedema of upper lip

    Directory of Open Access Journals (Sweden)

    Kavitha Mahendran

    2016-01-01

    Full Text Available Mishaps can occur during dental procedures, some owing to inattention to detail and others are totally unpredictable. They usually include anaphylaxis or allergic reactions to materials used for restorative purposes or drugs such as local anesthetics. A patient reported to our department with moderate dental fluorosis, and the treatment was planned with indirect composite veneering. During the procedure while cementation acute allergic reaction occurred, the specific cause could not be identified after allergic testing. During the procedure while cementationacute allergic angioedema of upper lip. Anaphylaxis, urticaria, allergy, hereditary atopic eczema, cellulitis, cheilitis granulomatosa, and cheilitis glandularis. The patient was reassured and given prednisolone 10 mg and cetirizine 10 mg orally, once daily for 3 days after which the symptoms subsided. This paper will discuss the pathogenesis, classification, identification, and management of angioedema during dental procedures.

  4. Pilonidal cyst on the vault: case report

    Directory of Open Access Journals (Sweden)

    BORGES GUILHERME

    1999-01-01

    Full Text Available Pilonidal cysts and sinuses are described as dermoid cysts which contain follicles of hairs and sebaceous glands. They clinically present as a classic case of inflammation which comes with pain, local infection and redness. The origin of pilonidal disease remains controverse. There are many hypothesis as lack of hygiene on the affected area and a penetration and growth of a hair in the subcutaneus tissue caused by constant friction or direct trauma on the damaged area. The option for clinical treatment is very frequent. However, taking into consideration the incidence and the possibility of recidive, surgical treatment is presently recommended. Complications include cellulitis and abscess formation. Pilonidal cysts are mostly found on the sacral region. In the literature is found description of pilonidal cysts on the penis, interdigital region on the hands as well as on the cervical region. We present a case of pilonidal cyst located on the vault biparietal region, without malignant degeneration.

  5. Pilonidal Sinus of the Glans Penis Associated with Actinomyces Case Reports and Review of Literature

    Directory of Open Access Journals (Sweden)

    Shylashree Chikkamuniyappa

    2004-01-01

    Full Text Available Pilonidal sinus is a well-recognized condition that occurs most commonly in the sacrococcygeal area of younger men. It is hypothesized to be an acquired chronic inflammation condition due mainly to hair trapped beneath the surface. A pilonidal sinus in the sacrococcygeal region is associated with recurrent infection, abscess formation, cellulitis, fistulae, and rarely, squamous cell carcinoma. A pilonidal sinus of the penis is a rare entity. The association of a penile pilonidal cyst and Actinomyces is even more uncommon with only three cases reported previously. Two cases of pilonidal sinus are reported in this paper. One of the cases was associated with actinomycosis. Pilonidal sinus of the penis should be considered in the clinical and pathological differential diagnosis and has to be distinguished from balanoposthitis, epidermal cyst, and carcinoma. The knowledge about possible association with actinomycosis is important to ensure early treatment.

  6. A Rare Case of Soft-Tissue Infection Caused by Raoultella planticola.

    Science.gov (United States)

    O' Connell, Karina; Kelly, Jack; Niriain, Una

    2010-01-01

    Raoultella species are Gram-negative, non-motile bacilli primarily considered to be environmental bacteria. Raoultella planticola is a rare cause of human infections. We report a case of serious soft-tissue infection in a young male tiler who presented with cellulitis of his left thumb. He had sustained a crush injury to his left thumb 10 days earlier in a soiled environment. He noted a minor break in the skin and he washed the wound out with running water. One week later, he experienced pain, erythema, and swelling of his thumb and attended his general practitioner who prescribed oral flucloxacillin and penicillin V. Despite this treatment, he noticed progressive erythema and swelling of his thumb requiring hospital admission 3 days later. He underwent washout and debridement of his thumb. Tissue obtained intraoperatively cultured Raoultella planticola. He was treated with broad-spectrum antibiotics including ciprofloxacin and made a full and rapid recovery.

  7. Evaluations of Molecular Nuclear Medicine in pediatric urgencies; Evaluaciones de Medicina Nuclear Molecular en urgencias pediatricas

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Duncker R, C. [Departamento de Medicina Nuclear Molecular, Hospital Infantil de Mexico, Mexico D.F. (Mexico)

    2000-07-01

    Several diagnostic procedures of Molecular Nuclear Medicine are considered in first choice in clinical evaluation of patients with different illnesses. So, the gammagraphy is the diagnostic form more sensitive to detect alterations of the perfusion on organs and systems such as bones, heart, brain, lungs or kidneys. Also is possible to identify, localize, evaluate the activity of inflammatory processes such as cellulitis, arthritis, osteomyelitis, the abscesses and several primary or metastatic tumours before each other diagnostic technique. In this work is treated about the importance of treatments with radioactive materials have been an important reappearance in last years since with the present capacity to localize specifically intracellular processes (for example, synthesis of DNA) new gateways are opened to research which in coming years would be of great utility. (Author)

  8. Antimicrobial prophylaxis in adults.

    Science.gov (United States)

    Enzler, Mark J; Berbari, Elie; Osmon, Douglas R

    2011-07-01

    Antimicrobial prophylaxis is commonly used by clinicians for the prevention of numerous infectious diseases, including herpes simplex infection, rheumatic fever, recurrent cellulitis, meningococcal disease, recurrent uncomplicated urinary tract infections in women, spontaneous bacterial peritonitis in patients with cirrhosis, influenza, infective endocarditis, pertussis, and acute necrotizing pancreatitis, as well as infections associated with open fractures, recent prosthetic joint placement, and bite wounds. Perioperative antimicrobial prophylaxis is recommended for various surgical procedures to prevent surgical site infections. Optimal antimicrobial agents for prophylaxis should be bactericidal, nontoxic, inexpensive, and active against the typical pathogens that can cause surgical site infection postoperatively. To maximize its effectiveness, intravenous perioperative prophylaxis should be administered within 30 to 60 minutes before the surgical incision. Antimicrobial prophylaxis should be of short duration to decrease toxicity and antimicrobial resistance and to reduce cost.

  9. Introduction to Views of Connectivism Theory of Learning

    Directory of Open Access Journals (Sweden)

    Sa’adi Sa’adi

    2016-07-01

    Full Text Available ‘Traditional’ theories of learning as pratical dimensions of psychology majorly tend to focus their interest on humans’ inner factors that influence the process of learning such as intelligences, motivation, interest, attitude, concentration and aptitude. They never connect it with instruments and technological inventions such as multimedia, cyber celluler, internet, even social organization, cultural values, traditions etc., while these are very influential nowdays towards the progress and behaviors of human life. As such the application of connectivism theory of learning which connect those dimensions of life with learning activities, is now and then insparable from any effort to promote the quality of humans’ learning itself, including in teaching and learning languages.

  10. Local and distant chemical burns due to cetrimide injection in a massive dose

    Directory of Open Access Journals (Sweden)

    Kumar S

    1990-01-01

    Full Text Available Sixty ml of 20% cetrimide shampoo solution was injected subcutaneously around the left elbow by a drug addict to commit suicide. Edema, blisters with skip areas and, cellulitis were noted within 6 hours, not only around the site of the injection but also upto the wrist and the pectoral region. Muscles were protected by the tough deep fascia. There was no systemic toxidcity despite receiving at least 4 times the reported fatal dose. The patient was treated with multiple fasciotomies, broad spectrum antibiotics, an atory drugs, iunb elevation and daily dressings, followed by secondary suturing of fasciotomy wounds when the limb edema regressed. The cutaneous bums healed without needing skin grafts.

  11. Études des propriétés électro-optiques d'une série de diphtalocyanines de terres rares

    Science.gov (United States)

    Videlot, C.; Fichou, D.; Garnier, F.

    1998-06-01

    In this work, we describe the study of photovoltaic cells for a series of rare earth diphthalocyanines. This p type organic compounds have been used in Schottky and pn configurations. Current-voltage curves and action spectra show different replies in energy's conversion according to the rare earth of the diphthalocyanine. Dans ce travail, nous décrivons l'étude de cellules photovoltaïques pour une série de diphtalocyanines de terres rares. Ces composés organiques de type p ont été étudiés dans des configurations Schottky et hétérojonction pn. Les courbes de courant-tension et les spectres d'action montrent des réponses différentes dans la conversion de l'énergie suivant la terre rare de la diphtalocyanine.

  12. Quadrupleur de fréquences en technologie SiGe:C BiCMOS 130 nm pour un radar à ondes continues modulées en bande-F

    OpenAIRE

    2013-01-01

    International audience; Dans cet article, nous présentons un quadrupleur de fréquences à 110 GHz conçu et développé en technologie SiGe:C BiCMOS 130 nm. Le circuit est conçu pour un système d'imagerie basé sur un radar à ondes continues modulées (FMCW) en bande-F et emploie une cascade de deux cellules de Gilbert avec des charges réactives réalisées avec des lignes de transmission TFML (thin-film microstrip line). Le signal d'entrée différentiel, qui est utilisé pour la validation du quadrupl...

  13. Pedal Gangrenous Changes in the Digits of an Adolescent With Ulcerative Colitis: A Case Report.

    Science.gov (United States)

    Bhoola, Prashant H; Shtofmakher, Garry; Bahri, Ankur; Patel, Ankur A; Barlizo, Sharon R; Trepal, Michael

    2016-01-01

    Ulcerative colitis is an autoimmune inflammatory disease of the colon and is occasionally associated with thrombosis. We report the case of an adolescent with ulcerative colitis who presented with bilateral gangrenous toes without signs of ascending cellulitis. Radiographs indicated the presence of bilateral and erosive changes in the distal phalanges. The vascular team referred the patient for podiatric intervention for distal vasculitis and thrombosis of the digital vessels. Transphalangeal amputations were performed, and postoperative antibiotics were initiated. The surgical sites healed uneventfully, and the patient was able to resume daily activities. Thrombosis of the foot in the context of ulcerative colitis is a rare, but serious, complication that can lead to serious comorbidities, including amputation.

  14. Une expérience scientifique et didactique : enseigner l’informatique aux biologistes

    OpenAIRE

    2014-01-01

    Tout a commencé avec James D. Watson, Francis Crick, Rosalind Elsie Franklin et quelques autres dans les années 1950. Ils nous ont appris que la conformation des êtres vivants se déduisait de l’information génétique codée par l’acide désoxyribonucléique (ADN) de leurs cellules. Les macromolécules (on dit aussi polymères) d’ADN sont de longues chaînes de motifs moléculaires élémentaires, les nucléotides, dont il existe quatre variétés : l’adénine (notée A), la thymine (notée T), la cytosine (n...

  15. Operadic Definition of Non-Stricts Cells

    CERN Document Server

    Kachour, Camell

    2010-01-01

    In [K. Kachour. D\\'efinition alg\\'ebrique des cellules non-strictes. Cahiers de Topologie et de G\\'eom\\'etrie Diff\\'erentielle Cat\\'egorique, 1:1-68, 2008] we pursue Penon's work in higher dimensional categories by defining non-strict infinity-functors, non-strict natural infinity-transformations, and so on, all that with Penon's frameworks i.e with the "\\'etirements cat\\'egoriques", where we have used an extension of this object, namely the "n-\\'etirements cat\\'egoriques" (n belong in N). In this paper we are pursuing Batanin's work in higher dimensional categories by defining nonstrict infinity-functors, non-strict natural infinity-transformations, and so on, using Batanin's frameworks i.e with the contractible operads, where we used an extension of this object, namely the globular colored contractible operads.

  16. Une étude comparative de dispositifs photovoltaïques multiples

    OpenAIRE

    Leguerre, J.R.; Leroy, M.

    1984-01-01

    Un calcul précis des valeurs des largeurs de bande interdite Eg k de matériaux hypothétiques et du rendement maximum η max correspondant a été effectué pour des associations multicolores de photopiles couplées en mode dichroïque, tandem ou cascade. L'effet d'un couplage optique par un miroir unique entre plusieurs cellules solaires isolées et/ou associées en mode tandem ou cascade a été particulièrement analysé ainsi que l'influence d'un couplage électrique par un simple fil conducteur entre ...

  17. Imaging of musculoskeletal soft tissue infections

    Energy Technology Data Exchange (ETDEWEB)

    Turecki, Marcin B.; Taljanovic, Mihra S.; Holden, Dean A.; Hunter, Tim B.; Rogers, Lee F. [University of Arizona HSC, Department of Radiology, Tucson, AZ (United States); Stubbs, Alana Y. [Southern Arizona VA Health Care System, Department of Radiology, Tucson, AZ (United States); Graham, Anna R. [University of Arizona HSC, Department of Pathology, Tucson, AZ (United States)

    2010-10-15

    Prompt and appropriate imaging work-up of the various musculoskeletal soft tissue infections aids early diagnosis and treatment and decreases the risk of complications resulting from misdiagnosis or delayed diagnosis. The signs and symptoms of musculoskeletal soft tissue infections can be nonspecific, making it clinically difficult to distinguish between disease processes and the extent of disease. Magnetic resonance imaging (MRI) is the imaging modality of choice in the evaluation of soft tissue infections. Computed tomography (CT), ultrasound, radiography and nuclear medicine studies are considered ancillary. This manuscript illustrates representative images of superficial and deep soft tissue infections such as infectious cellulitis, superficial and deep fasciitis, including the necrotizing fasciitis, pyomyositis/soft tissue abscess, septic bursitis and tenosynovitis on different imaging modalities, with emphasis on MRI. Typical histopathologic findings of soft tissue infections are also presented. The imaging approach described in the manuscript is based on relevant literature and authors' personal experience and everyday practice. (orig.)

  18. MRSA bacteraemia complicating amphotericin B treatment of cryptococcal meningitis

    Directory of Open Access Journals (Sweden)

    J Scriven

    2013-09-01

    Full Text Available Intravenous amphotericin B is a key component of the antifungal therapy for cryptococcal meningitis recommended in South African and international guidelines. Unfortunately, its use is associated with significant toxicity including deterioration in renal function, electrolyte disturbance, anaemia and infusion reactions. Chemical phlebitis is common following administration via peripheral cannulae. This can be complicated by bacterial infection, resulting in localised cellulitis or bacterial sepsis. Here we describe two patients with cryptococcal meningitis who developed methicillin-resistant Staphylococcus aureus (MRSA bacteraemia during, or shortly after treatment with amphotericin B. These cases illustrate the dangers of line-related sepsis in hospitalised individuals and some of the difficulties encountered during treatment of this condition.

  19. A ''not so superficial" skin infection in a patient with diabetes.

    Science.gov (United States)

    Carr, James Michael; Hagan, Guy; Guest, Peter; Gompertz, Simon

    2012-10-30

    A woman in her 60s with type 2 diabetes presented with a 4-week history of a rash on her chest wall, flu-like symptoms and a red right eye. On examination, there was a cellulitic rash over the right chest wall, breast and neck and a hypopyon in the right eye. Chest x-ray demonstrated right upper lobe opacification, with subsequent CT and MRI revealing bilateral collections at the lung apices, and a possible permeative bone destruction of the manubrium, respectively. A diagnosis of primary sternal osteomyelitis with associated lung abscesses, chest wall cellulitis and hypopyon due to endogenous endophthalmitis was made, with microbiological assessment identifying group B β-haemolytic streptococci. The patient underwent surgical debridement of the affected tissue and received 6 weeks of intravenous antibiotics. This case highlights the role of multidisciplinary team involvement in management of infections and the need to consider deep-seated infection in diabetics.

  20. Evaluation de la performance et de l'impact de la veille

    OpenAIRE

    Bezençon, Christophe; Roulet, Aurélie; Madinier, Hélène

    2014-01-01

    Ce travail de recherche, réalisé dans le cadre du Master en Information documentaire de la Haute école de gestion de Genève, développe, dans un premier temps, une réflexion sur la mesure de l’efficacité et l’impact de la veille issue de la littérature sur le sujet et d’entretiens menés auprès de praticiens. Dans un second temps, il propose une version bêta d’un outil générique permettant de mettre en place ce type de mesures par une cellule de veille. L’état de l’art, basé tant sur la littéra...